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Search of human proteins with 9665248
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|9665248 transporter 1, ATP-binding cassette, sub-family B
[Homo sapiens]
(808 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 1598 0.0
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 464 e-130
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 464 e-130
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 419 e-117
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 409 e-114
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 396 e-110
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 338 2e-92
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 301 1e-81
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 263 5e-70
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 258 2e-68
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 258 2e-68
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 258 2e-68
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 254 2e-67
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 241 1e-63
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 188 2e-47
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 186 1e-46
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 164 4e-40
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 162 1e-39
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 159 1e-38
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 154 3e-37
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 148 2e-35
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 148 2e-35
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 148 2e-35
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 148 2e-35
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 137 4e-32
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 136 7e-32
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 134 4e-31
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 121 2e-27
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 117 3e-26
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 117 3e-26
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 1598 bits (4139), Expect = 0.0
Identities = 808/808 (100%), Positives = 808/808 (100%)
Query: 1 MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVP 60
MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVP
Sbjct: 1 MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVP 60
Query: 61 MASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAV 120
MASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAV
Sbjct: 61 MASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAV 120
Query: 121 GLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWG 180
GLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWG
Sbjct: 121 GLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWG 180
Query: 181 APGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCL 240
APGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCL
Sbjct: 181 APGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCL 240
Query: 241 GSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAV 300
GSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAV
Sbjct: 241 GSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAV 300
Query: 301 LEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLS 360
LEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLS
Sbjct: 301 LEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLS 360
Query: 361 ENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESL 420
ENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESL
Sbjct: 361 ENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESL 420
Query: 421 AKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGM 480
AKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGM
Sbjct: 421 AKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGM 480
Query: 481 LLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFE 540
LLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFE
Sbjct: 481 LLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFE 540
Query: 541 YLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPN 600
YLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPN
Sbjct: 541 YLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPN 600
Query: 601 GSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIA 660
GSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIA
Sbjct: 601 GSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIA 660
Query: 661 YGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRK 720
YGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRK
Sbjct: 661 YGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRK 720
Query: 721 PCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAI 780
PCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAI
Sbjct: 721 PCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAI 780
Query: 781 REGGTHQQLMEKKGCYWAMVQAPADAPE 808
REGGTHQQLMEKKGCYWAMVQAPADAPE
Sbjct: 781 REGGTHQQLMEKKGCYWAMVQAPADAPE 808
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 464 bits (1193), Expect = e-130
Identities = 242/579 (41%), Positives = 377/579 (65%), Gaps = 3/579 (0%)
Query: 223 PGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSAD 282
P + SG +++LL + L +++++LGE +P++TGR D I+ S D
Sbjct: 164 PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMD 223
Query: 283 TFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTG 342
F+ + ++ +L I S+ + GI+ ++ L+ +F +++ QET FF +N+TG
Sbjct: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTG 283
Query: 343 NIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLP 402
+++SR+T DT+ +SD +S+N+++FL V+ ++ M S L++VT + P++ ++
Sbjct: 284 DLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVS 343
Query: 403 KKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQ 462
GK+Y+ L +V+ +LA++S A E +SAM TVRSFANEE EA+ + KLQ++ LN+
Sbjct: 344 NIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNR 403
Query: 463 KEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLL 522
KEA AY W + ++ ++++V ILY GG LV SG ++SGNL+ F++Y+ +E +
Sbjct: 404 KEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVG 463
Query: 523 SIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQ 582
S+Y + + VG++EK+FE++DR P G L P HLEG V F++V+F Y RP VLQ
Sbjct: 464 SVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQ 523
Query: 583 GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVA 642
++F+L PG+VTALVGP+GSGKS+ +L+N Y GG++LLDGKP+ Y+H+YLHR ++
Sbjct: 524 NVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVIS 583
Query: 643 AVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQ 702
V QEP +F RS+ +NI+YGL P E + AA K+ AH FI L GY TE E G+Q
Sbjct: 584 LVSQEPVLFARSITDNISYGLPTVP-FEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQ 642
Query: 703 LSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQH 762
LSGGQ+Q VA+ARAL+R P VLILD+ATSALDA S+ ++Q ++ + +++ +VL+I
Sbjct: 643 LSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKH--TVLIIAHR 700
Query: 763 LSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
LS VE A I+ L+ G + + GTHQQL+ + G Y +VQ
Sbjct: 701 LSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 464 bits (1193), Expect = e-130
Identities = 242/579 (41%), Positives = 377/579 (65%), Gaps = 3/579 (0%)
Query: 223 PGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSAD 282
P + SG +++LL + L +++++LGE +P++TGR D I+ S D
Sbjct: 164 PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMD 223
Query: 283 TFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTG 342
F+ + ++ +L I S+ + GI+ ++ L+ +F +++ QET FF +N+TG
Sbjct: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTG 283
Query: 343 NIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLP 402
+++SR+T DT+ +SD +S+N+++FL V+ ++ M S L++VT + P++ ++
Sbjct: 284 DLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVS 343
Query: 403 KKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQ 462
GK+Y+ L +V+ +LA++S A E +SAM TVRSFANEE EA+ + KLQ++ LN+
Sbjct: 344 NIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNR 403
Query: 463 KEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLL 522
KEA AY W + ++ ++++V ILY GG LV SG ++SGNL+ F++Y+ +E +
Sbjct: 404 KEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVG 463
Query: 523 SIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQ 582
S+Y + + VG++EK+FE++DR P G L P HLEG V F++V+F Y RP VLQ
Sbjct: 464 SVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQ 523
Query: 583 GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVA 642
++F+L PG+VTALVGP+GSGKS+ +L+N Y GG++LLDGKP+ Y+H+YLHR ++
Sbjct: 524 NVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVIS 583
Query: 643 AVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQ 702
V QEP +F RS+ +NI+YGL P E + AA K+ AH FI L GY TE E G+Q
Sbjct: 584 LVSQEPVLFARSITDNISYGLPTVP-FEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQ 642
Query: 703 LSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQH 762
LSGGQ+Q VA+ARAL+R P VLILD+ATSALDA S+ ++Q ++ + +++ +VL+I
Sbjct: 643 LSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKH--TVLIIAHR 700
Query: 763 LSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
LS VE A I+ L+ G + + GTHQQL+ + G Y +VQ
Sbjct: 701 LSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 419 bits (1076), Expect = e-117
Identities = 276/720 (38%), Positives = 404/720 (56%), Gaps = 39/720 (5%)
Query: 88 LLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENA 147
LLL D LL L L+P LP L W G R LW G+L+
Sbjct: 12 LLLVDAALL-WLLQGPLGTLLPQGLPGL--WLEGTLRLGGLW----GLLKL--------- 55
Query: 148 GAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAA 207
+G L + L L LA P R L++ + W + +V Y AA
Sbjct: 56 --RGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPW----SWLLVGYGAA 109
Query: 208 LPAAALWHKLGSLWVPGGQGGSGNPVR------RLLGCLGSETRRLSLFLVLVVLSSLGE 261
+ +LW L PG Q + V RLL + L +VL+ LGE
Sbjct: 110 GLSWSLWAVLSP---PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGE 166
Query: 262 MAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQ 321
IP ++GR+ D + D F + M + + S++ G + TM ++ ++
Sbjct: 167 TLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIR 226
Query: 322 GEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIML 381
++F ++LRQ+ FFQ+ +TG + SR++ DT+ +S+ L N ++ L LV+ + L G ML
Sbjct: 227 EQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFML 286
Query: 382 WGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFA 441
S LT+++L+ +P K +Q + ++++++A++ QV EA+ + TVRSF
Sbjct: 287 SISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFG 346
Query: 442 NEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSS 501
EE E +++E L++ + L + + A+ + + +++ +L G Q + G ++
Sbjct: 347 AEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQ 406
Query: 502 GNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEG 561
G+L++F++YQ V+ L+ IY + VG++EK+F Y+DR P P G L P L+G
Sbjct: 407 GSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQG 466
Query: 562 LVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 621
+V+FQDVSFAYPNRPD VL+GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ
Sbjct: 467 VVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 526
Query: 622 LLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGA 681
+LLD KP+ QYEH YLH QV +VGQEP +F S++ NIAYGL Q +++ AAA + A
Sbjct: 527 VLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL-QSCEDDKVMAAAQAAHA 585
Query: 682 HSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQV 741
FI + G T+V E GSQL+ GQ+Q +A+ARAL+R P VLILD+ATSALD +Q
Sbjct: 586 DDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALD----VQC 641
Query: 742 EQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
EQ L + R R+VL+I L V++A IL L+ G +++ QL E + Y +VQ
Sbjct: 642 EQALQDWNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK---LAQLQEGQDLYSRLVQ 698
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 409 bits (1050), Expect = e-114
Identities = 228/579 (39%), Positives = 349/579 (60%), Gaps = 46/579 (7%)
Query: 223 PGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSAD 282
P + SG +++LL + L +++++LGE +P++TGR D I+ S D
Sbjct: 164 PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMD 223
Query: 283 TFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTG 342
F+ + ++ +L I S+ + GI+ ++ L+ +F +++ QET FF +N+TG
Sbjct: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTG 283
Query: 343 NIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLP 402
+++SR+T DT+ +SD +S+N+++FL V+ ++ M S L++VT + P++ ++
Sbjct: 284 DLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVS 343
Query: 403 KKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQ 462
GK+Y+ L +V+ +LA++S A E +SAM TVRSFANEE EA+ + KLQ++ LN+
Sbjct: 344 NIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNR 403
Query: 463 KEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLL 522
KEA AY W SG+V S
Sbjct: 404 KEAAAYMYYVWG---------------------SGSVGS--------------------- 421
Query: 523 SIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQ 582
+Y + + VG++EK+FE++DR P G L P HLEG V F++V+F Y RP VLQ
Sbjct: 422 -VYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQ 480
Query: 583 GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVA 642
++F+L PG+VTALVGP+GSGKS+ +L+N Y GG++LLDGKP+ Y+H+YLHR ++
Sbjct: 481 NVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVIS 540
Query: 643 AVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQ 702
V QEP +F RS+ +NI+YGL P E + AA K+ AH FI L GY TE E G+Q
Sbjct: 541 LVSQEPVLFARSITDNISYGLPTVP-FEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQ 599
Query: 703 LSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQH 762
LSGGQ+Q VA+ARAL+R P VLILD+ATSALDA S+ ++Q ++ + +++ +VL+I
Sbjct: 600 LSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKH--TVLIIAHR 657
Query: 763 LSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
LS VE A I+ L+ G + + GTHQQL+ + G Y +VQ
Sbjct: 658 LSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 696
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 396 bits (1017), Expect = e-110
Identities = 254/657 (38%), Positives = 371/657 (56%), Gaps = 32/657 (4%)
Query: 88 LLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENA 147
LLL D LL L L+P LP L W G R LW G+L+
Sbjct: 12 LLLVDAALL-WLLQGPLGTLLPQGLPGL--WLEGTLRLGGLW----GLLKL--------- 55
Query: 148 GAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAA 207
+G L + L L LA P R L++ + W + +V Y AA
Sbjct: 56 --RGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPW----SWLLVGYGAA 109
Query: 208 LPAAALWHKLGSLWVPGGQGGSGNPVR------RLLGCLGSETRRLSLFLVLVVLSSLGE 261
+ +LW L PG Q + V RLL + L +VL+ LGE
Sbjct: 110 GLSWSLWAVLSP---PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGE 166
Query: 262 MAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQ 321
IP ++GR+ D + D F + M + + S++ G + TM ++ ++
Sbjct: 167 TLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIR 226
Query: 322 GEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIML 381
++F ++LRQ+ FFQ+ +TG + SR++ DT+ +S+ L N ++ L LV+ + L G ML
Sbjct: 227 EQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFML 286
Query: 382 WGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFA 441
S LT+++L+ +P K +Q + ++++++A++ QV EA+ + TVRSF
Sbjct: 287 SISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFG 346
Query: 442 NEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSS 501
EE E +++E L++ + L + + A+ + + +++ +L G Q + G ++
Sbjct: 347 AEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQ 406
Query: 502 GNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEG 561
G+L++F++YQ V+ L+ IY + VG++EK+F Y+DR P P G L P L+G
Sbjct: 407 GSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQG 466
Query: 562 LVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 621
+V+FQDVSFAYPNRPD VL+GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ
Sbjct: 467 VVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 526
Query: 622 LLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGA 681
+LLD KP+ QYEH YLH QV +VGQEP +F S++ NIAYGL Q +++ AAA + A
Sbjct: 527 VLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGL-QSCEDDKVMAAAQAAHA 585
Query: 682 HSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQ 738
FI + G T+V E GSQL+ GQ+Q +A+ARAL+R P VLILD+ATSALD +
Sbjct: 586 DDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 338 bits (866), Expect = 2e-92
Identities = 246/748 (32%), Positives = 386/748 (51%), Gaps = 48/748 (6%)
Query: 65 RCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVP-TALPLLRVWAVGLS 123
R P R L S A G +L + W A R+ L P T L R+W G
Sbjct: 2 RGPPAWPLRLLEPPSPAEPGRLLPVACVWA----AASRVPGSLSPFTGLRPARLWGAGP- 56
Query: 124 RWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWGAPG 183
A+LW GV A G G + LA LGL G R ++ PG
Sbjct: 57 --ALLW----GVGAARRWRSGCRGGGPGASRGVLGLARLLGLWARGPGSCR-CGAFAGPG 109
Query: 184 SADSTRLLHWGSHPTAFVVSYAAALPAAALWH-----KLGSLWVPGGQG-----GSGNP- 232
+ R G PAAA W + G PG +G +G P
Sbjct: 110 APRLPRARFPGG-------------PAAAAWAGDEAWRRGPAAPPGDKGRLRPAAAGLPE 156
Query: 233 VRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLM- 291
R+LLG E RRL+ + + +SS+ M+ PFF G++ D I + + D ++ NLT +
Sbjct: 157 ARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIYTNPTVD-YSDNLTRLC 215
Query: 292 ---SILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRV 348
S + + A + + + + + L+ +F ++LRQE FF + +TG +++R+
Sbjct: 216 LGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRL 275
Query: 349 TEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKW 408
+ DT+ L S++ENLS L + + +M + S +L L +P + ++ G++
Sbjct: 276 SSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRY 335
Query: 409 YQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAY 468
+ L ++SLA+++Q+A E + + TVR+F E E +K+ K+ + L +KEA A
Sbjct: 336 LRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFAR 395
Query: 469 AVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRV 528
A T +SG L+ + +LY GG L+ S ++ G L +F++Y ++ L S Y +
Sbjct: 396 AGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSFYSEL 455
Query: 529 QKAVGSSEKIFEYLDRTPRCP--PSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTF 586
K +G+ +++E L+R P+ P +L +G ++F++V FAYP RP+V + Q +
Sbjct: 456 MKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSL 515
Query: 587 TLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQ 646
++ G VTALVGP+GSGKSTV +LL LY P G + LDG + Q +L ++ V Q
Sbjct: 516 SIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQ 575
Query: 647 EPQVFGRSLQENIAYGL--TQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLS 704
EP +F S+ ENIAYG T EEI A + A +FI PQG++T V E G LS
Sbjct: 576 EPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLS 635
Query: 705 GGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLS 764
GGQ+Q +A+ARAL++ P +L+LD+ATSALDA ++ V++ L + R+VL+I LS
Sbjct: 636 GGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMD--GRTVLVIAHRLS 693
Query: 765 LVEQADHILFLEGGAIREGGTHQQLMEK 792
++ A+ + L+ G I E G H++L+ K
Sbjct: 694 TIKNANMVAVLDQGKITEYGKHEELLSK 721
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 301 bits (772), Expect = 1e-81
Identities = 195/572 (34%), Positives = 326/572 (56%), Gaps = 15/572 (2%)
Query: 247 LSLFLVLVVLSSLGEMAIPFFTGRLTDWILQD-----GSADTFTRNL-TLMSILTIASAV 300
L + +VL + ++L + IP G+L + + + GS T ++NL T + IL +
Sbjct: 131 LGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLSTHLLILYGVQGL 190
Query: 301 LEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLS 360
L F + ++ + ++ +F ++LRQ+ FF N+TG ++SR+T D S
Sbjct: 191 LTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFK 250
Query: 361 ENLSLFLWYLVRGL-CLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRES 419
+S L + CL+ + + S LT++ ++ P L + +G + L Q +E
Sbjct: 251 LVISQGLRSCTQVAGCLVSLSML-STRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQ 309
Query: 420 LAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISG 479
+A++ VA EAL + TVR+FA E+ E +++ +L+ + ++ A+ ++I+
Sbjct: 310 IARAMGVADEALGNVRTVRAFAMEQREEERYGAELEACRCRAEELGRGIALFQGLSNIAF 369
Query: 480 MLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIF 539
+ +G L+IGG LV ++ G+L++F++ +++ L ++ +V + + + ++F
Sbjct: 370 NCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVF 429
Query: 540 EYLDRTPRCPPSG--LLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALV 597
EY+ P P SG + L G V FQ+V F+YP RP VL+ T TL PG++ ALV
Sbjct: 430 EYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALV 489
Query: 598 GPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAA-VGQEPQVFGRSLQ 656
G +G GK+TVA+LL+ Y PT G ++LDG+ L + +L QV + QEP +FG ++
Sbjct: 490 GQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIM 549
Query: 657 ENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARA 716
ENI +G + EE+ AA ++ AH FI+ P+GY+T V E G+ LSGGQ+Q +A+ARA
Sbjct: 550 ENIRFGKLEASD-EEVYTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARA 608
Query: 717 LIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLE 776
LI++P VLILD+ATSALDA S+ V++ L + R+VL+I LS V A I+ +
Sbjct: 609 LIKQPTVLILDEATSALDAESERVVQEALDRASA--GRTVLVIAHRLSTVRGAHCIVVMA 666
Query: 777 GGAIREGGTHQQLMEKKGCYWAMVQAPA-DAP 807
G + E GTH++L++K G Y +++ A DAP
Sbjct: 667 DGRVWEAGTHEELLKKGGLYAELIRRQALDAP 698
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 263 bits (672), Expect = 5e-70
Identities = 173/535 (32%), Positives = 282/535 (52%), Gaps = 17/535 (3%)
Query: 282 DTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGH----VHSHLQGEVFGAVLRQETEFFQ 337
+T +N L S+L +A ++ F+ + T G + L+ VF ++LRQ+ +F
Sbjct: 746 ETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFD 805
Query: 338 --QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVR---GLCLLGIMLWGSVSLTMVTL 392
+N TG + +R+ D + + ++ L++ + G+ + I W LT++ L
Sbjct: 806 DPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW---QLTLLLL 862
Query: 393 ITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFRE 452
+P++ + K ++ ++ L S ++A EA+ TV S E+ + +
Sbjct: 863 AIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQ 922
Query: 453 KLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQM 512
LQ + ++A + + T G G LV +S +++ +
Sbjct: 923 SLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVV 982
Query: 513 QFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGL--LTPLHLEGLVQFQDVSF 570
AV + S P KA S+ I +++TP L P LEG V F +V F
Sbjct: 983 FGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVF 1042
Query: 571 AYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLP 630
YP RPD+ VLQGL+ ++ G+ ALVG +G GKSTV LL+ Y P G++LLDGK +
Sbjct: 1043 NYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIK 1102
Query: 631 QYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQK-PTMEEITAAAVKSGAHSFISGLP 689
+ ++L + V QEP +F S+ ENIAYG + + EEI AA ++ H+FI LP
Sbjct: 1103 RLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLP 1162
Query: 690 QGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESP 749
Y T+V + G+QLSGGQ+Q +A+ARAL+R+P +L+LD+ATSALD S+ V++ L ++
Sbjct: 1163 NKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA- 1221
Query: 750 ERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPA 804
R R+ ++I LS ++ AD I+ + G ++E GTHQQL+ +KG Y++MV A
Sbjct: 1222 -REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275
Score = 254 bits (649), Expect = 2e-67
Identities = 157/486 (32%), Positives = 262/486 (53%), Gaps = 11/486 (2%)
Query: 320 LQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGI 379
++ + F A++RQE +F + G + +R+T+D S +++ + + + +F + +
Sbjct: 147 IRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIV 206
Query: 380 MLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESL---AKSSQVAIEALSAMPT 436
LT+V L P+L L W ++L + L AK+ VA E L+A+ T
Sbjct: 207 GFTRGWKLTLVILAISPVLGL---SAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 263
Query: 437 VRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTS 496
V +F ++ E +++ + L+E K + K+A+ ++ + + G LV S
Sbjct: 264 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS 323
Query: 497 GAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLL-- 554
G S G ++T + +V A G++ +IF+ +D P
Sbjct: 324 GEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 383
Query: 555 TPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNL 614
P +++G ++F++V F+YP+R +V +L+GL ++ G+ ALVG +G GKST L+Q L
Sbjct: 384 KPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 443
Query: 615 YQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITA 674
Y PT G + +DG+ + R+L + V QEP +F ++ ENI YG + TM+EI
Sbjct: 444 YDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEK 502
Query: 675 AAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALD 734
A ++ A+ FI LP +DT V E G+QLSGGQ+Q +A+ARAL+R P +L+LD+ATSALD
Sbjct: 503 AVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 562
Query: 735 ANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKG 794
S+ V+ L ++ R R+ ++I LS V AD I + G I E G H +LM++KG
Sbjct: 563 TESEAVVQVALDKA--RKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKG 620
Query: 795 CYWAMV 800
Y+ +V
Sbjct: 621 IYFKLV 626
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 258 bits (658), Expect = 2e-68
Identities = 164/521 (31%), Positives = 267/521 (51%), Gaps = 5/521 (0%)
Query: 282 DTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQT 341
+ TR S L V ++ + G ++ + F A+LRQE +F N T
Sbjct: 111 EEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDT 170
Query: 342 GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLL 401
+ +R+T+D S +S+ + + + +F + + LT+V + P+L L
Sbjct: 171 TELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLS 230
Query: 402 PKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN 461
K + + AK+ VA EAL A+ TV +F + E +++++ L+ K +
Sbjct: 231 AAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG 290
Query: 462 QKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVL 521
K+A++ ++ + + G LV S + GN +T + +V
Sbjct: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
Query: 522 LSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLL--TPLHLEGLVQFQDVSFAYPNRPDVL 579
A G++ IF+ +D P+ P ++G ++F DV F+YP+R +V
Sbjct: 351 APCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVK 410
Query: 580 VLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHR 639
+L+GL ++ G+ ALVG +G GKST L+Q LY P G + +DG+ + + YL
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
Query: 640 QVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
+ V QEP +F ++ ENI YG TM+EI A ++ A+ FI LPQ +DT V E
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 700 GSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLI 759
G+QLSGGQ+Q +A+ARAL+R P +L+LD+ATSALD S+ +V+ L ++ R R+ ++I
Sbjct: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA--REGRTTIVI 587
Query: 760 TQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV 800
LS V AD I E G I E G+H +LM+K+G Y+ +V
Sbjct: 588 AHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
Score = 231 bits (589), Expect = 2e-60
Identities = 160/500 (32%), Positives = 256/500 (51%), Gaps = 20/500 (4%)
Query: 320 LQGEVFGAVLRQETEFFQ--QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVR---GL 374
L+ F A+LRQ+ +F +N TG + +R+ D + + + L+L + G+
Sbjct: 787 LRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGI 846
Query: 375 CLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAM 434
+ I W LT++ L +P++ + K + ++ L + ++A EA+ +
Sbjct: 847 IISFIYGW---QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENI 903
Query: 435 PTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLV 494
TV S E + EKL + ++A Y + + G G L+
Sbjct: 904 RTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLI 963
Query: 495 TSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGL- 553
+G + +++ + A+ S P KA S+ +F +R P
Sbjct: 964 VNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEE 1023
Query: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
L P EG + F +V F YP R +V VLQGL+ ++ G+ ALVG +G GKSTV LL+
Sbjct: 1024 GLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE 1083
Query: 613 NLYQPTGGQL-------LLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQ 665
Y P G + LLDG+ + ++L Q+ V QEP +F S+ ENIAYG
Sbjct: 1084 RFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNS 1143
Query: 666 KP-TMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVL 724
+ + +EI +AA + H FI LP Y+T V + G+QLSGGQ+Q +A+ARALIR+P +L
Sbjct: 1144 RVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQIL 1203
Query: 725 ILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGG 784
+LD+ATSALD S+ V++ L ++ R R+ ++I LS ++ AD I+ + G ++E G
Sbjct: 1204 LLDEATSALDTESEKVVQEALDKA--REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHG 1261
Query: 785 THQQLMEKKGCYWAMVQAPA 804
THQQL+ +KG Y++MV A
Sbjct: 1262 THQQLLAQKGIYFSMVSVQA 1281
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 258 bits (658), Expect = 2e-68
Identities = 164/521 (31%), Positives = 267/521 (51%), Gaps = 5/521 (0%)
Query: 282 DTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQT 341
+ TR S L V ++ + G ++ + F A+LRQE +F N T
Sbjct: 111 EEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDT 170
Query: 342 GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLL 401
+ +R+T+D S +S+ + + + +F + + LT+V + P+L L
Sbjct: 171 TELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLS 230
Query: 402 PKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN 461
K + + AK+ VA EAL A+ TV +F + E +++++ L+ K +
Sbjct: 231 AAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG 290
Query: 462 QKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVL 521
K+A++ ++ + + G LV S + GN +T + +V
Sbjct: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
Query: 522 LSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLL--TPLHLEGLVQFQDVSFAYPNRPDVL 579
A G++ IF+ +D P+ P ++G ++F DV F+YP+R +V
Sbjct: 351 APCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVK 410
Query: 580 VLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHR 639
+L+GL ++ G+ ALVG +G GKST L+Q LY P G + +DG+ + + YL
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
Query: 640 QVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
+ V QEP +F ++ ENI YG TM+EI A ++ A+ FI LPQ +DT V E
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 700 GSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLI 759
G+QLSGGQ+Q +A+ARAL+R P +L+LD+ATSALD S+ +V+ L ++ R R+ ++I
Sbjct: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA--REGRTTIVI 587
Query: 760 TQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV 800
LS V AD I E G I E G+H +LM+K+G Y+ +V
Sbjct: 588 AHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
Score = 224 bits (572), Expect = 2e-58
Identities = 160/493 (32%), Positives = 247/493 (50%), Gaps = 60/493 (12%)
Query: 320 LQGEVFGAVLRQETEFFQ--QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVR---GL 374
L+ F A+LRQ+ +F +N TG + +R+ D + + + L+L + G+
Sbjct: 787 LRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGI 846
Query: 375 CLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAM 434
+ I W LT++ L +P++ + K + ++ L + ++A EA+ +
Sbjct: 847 IISFIYGW---QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENI 903
Query: 435 PTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLV 494
TV S E + EKL Y V S +
Sbjct: 904 RTVVSLTQERKFESMYVEKLYG----------PYRVFS--------------------AI 933
Query: 495 TSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGL- 553
GAV+ G+ +F P KA S+ +F +R P
Sbjct: 934 VFGAVALGHASSFA-----------------PDYAKAKLSAAHLFMLFERQPLIDSYSEE 976
Query: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
L P EG + F +V F YP R +V VLQGL+ ++ G+ ALVG +G GKSTV LL+
Sbjct: 977 GLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE 1036
Query: 613 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQK-PTMEE 671
Y P G +LLDG+ + ++L Q+ V QEP +F S+ ENIAYG + + +E
Sbjct: 1037 RFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1096
Query: 672 ITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATS 731
I +AA + H FI LP Y+T V + G+QLSGGQ+Q +A+ARALIR+P +L+LD+ATS
Sbjct: 1097 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1156
Query: 732 ALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLME 791
ALD S+ V++ L ++ R R+ ++I LS ++ AD I+ + G ++E GTHQQL+
Sbjct: 1157 ALDTESEKVVQEALDKA--REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA 1214
Query: 792 KKGCYWAMVQAPA 804
+KG Y++MV A
Sbjct: 1215 QKGIYFSMVSVQA 1227
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 258 bits (658), Expect = 2e-68
Identities = 164/521 (31%), Positives = 267/521 (51%), Gaps = 5/521 (0%)
Query: 282 DTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQT 341
+ TR S L V ++ + G ++ + F A+LRQE +F N T
Sbjct: 111 EEMTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDT 170
Query: 342 GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLL 401
+ +R+T+D S +S+ + + + +F + + LT+V + P+L L
Sbjct: 171 TELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLS 230
Query: 402 PKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN 461
K + + AK+ VA EAL A+ TV +F + E +++++ L+ K +
Sbjct: 231 AAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIG 290
Query: 462 QKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVL 521
K+A++ ++ + + G LV S + GN +T + +V
Sbjct: 291 IKKAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQA 350
Query: 522 LSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLL--TPLHLEGLVQFQDVSFAYPNRPDVL 579
A G++ IF+ +D P+ P ++G ++F DV F+YP+R +V
Sbjct: 351 APCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVK 410
Query: 580 VLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHR 639
+L+GL ++ G+ ALVG +G GKST L+Q LY P G + +DG+ + + YL
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470
Query: 640 QVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEA 699
+ V QEP +F ++ ENI YG TM+EI A ++ A+ FI LPQ +DT V E
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYG-RGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGER 529
Query: 700 GSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLI 759
G+QLSGGQ+Q +A+ARAL+R P +L+LD+ATSALD S+ +V+ L ++ R R+ ++I
Sbjct: 530 GAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKA--REGRTTIVI 587
Query: 760 TQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV 800
LS V AD I E G I E G+H +LM+K+G Y+ +V
Sbjct: 588 AHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLV 628
Score = 238 bits (607), Expect = 2e-62
Identities = 160/493 (32%), Positives = 256/493 (51%), Gaps = 13/493 (2%)
Query: 320 LQGEVFGAVLRQETEFFQ--QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVR---GL 374
L+ F A+LRQ+ +F +N TG + +R+ D + + + L+L + G+
Sbjct: 787 LRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGI 846
Query: 375 CLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAM 434
+ I W LT++ L +P++ + K + ++ L + ++A EA+ +
Sbjct: 847 IISFIYGW---QLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENI 903
Query: 435 PTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLV 494
TV S E + EKL + ++A Y + + G G L+
Sbjct: 904 RTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYFSYAGCFRFGAYLI 963
Query: 495 TSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGL- 553
+G + +++ + A+ S P KA S+ +F +R P
Sbjct: 964 VNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEE 1023
Query: 554 -LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQ 612
L P EG + F +V F YP R +V VLQGL+ ++ G+ ALVG +G GKSTV LL+
Sbjct: 1024 GLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLE 1083
Query: 613 NLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQK-PTMEE 671
Y P G +LLDG+ + ++L Q+ V QEP +F S+ ENIAYG + + +E
Sbjct: 1084 RFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDE 1143
Query: 672 ITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATS 731
I +AA + H FI LP Y+T V + G+QLSGGQ+Q +A+ARALIR+P +L+LD+ATS
Sbjct: 1144 IVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATS 1203
Query: 732 ALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLME 791
ALD S+ V++ L ++ R R+ ++I LS ++ AD I+ + G ++E GTHQQL+
Sbjct: 1204 ALDTESEKVVQEALDKA--REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLA 1261
Query: 792 KKGCYWAMVQAPA 804
+KG Y++MV A
Sbjct: 1262 QKGIYFSMVSVQA 1274
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 254 bits (649), Expect = 2e-67
Identities = 154/479 (32%), Positives = 256/479 (53%), Gaps = 6/479 (1%)
Query: 325 FGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGS 384
F ++R E +F N G + +R ++D + ++D++++ ++LF+ + +C + +
Sbjct: 179 FRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRG 238
Query: 385 VSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEE 444
LT+V + PL+ + +G ++ AK+ VA E +S+M TV +F E+
Sbjct: 239 WKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEK 298
Query: 445 GEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTS-GAVSSGN 503
E +++ + L + ++ + + L + G LV G + G
Sbjct: 299 REVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGT 358
Query: 504 LVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTP--RCPPSGLLTPLHLEG 561
LV L + + ++ IFE +DR P C ++G
Sbjct: 359 LVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKG 418
Query: 562 LVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQ 621
++F +V+F YP+RP+V +L L ++PGE+TALVGP+G+GKST L+Q Y P G
Sbjct: 419 EIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGM 478
Query: 622 LLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGA 681
+ +DG + ++L Q+ V QEP +F ++ ENI YG + TME+I AA ++ A
Sbjct: 479 VTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYG-REDATMEDIVQAAKEANA 537
Query: 682 HSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQV 741
++FI LPQ +DT V E G Q+SGGQ+Q VA+ARALIR P +L+LD ATSALD S+ V
Sbjct: 538 YNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMV 597
Query: 742 EQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMV 800
+++L S ++ +++ + LS V AD I+ E G E GTH++L+E+KG Y+ +V
Sbjct: 598 QEVL--SKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLV 654
Score = 219 bits (558), Expect = 8e-57
Identities = 147/485 (30%), Positives = 243/485 (50%), Gaps = 15/485 (3%)
Query: 325 FGAVLRQETEFFQ--QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLW 382
F A+L Q+ +F +N G + +R+ D S + + + + + + I
Sbjct: 836 FRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFS 895
Query: 383 GSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFAN 442
S L++V L P L L + + +++L Q+ EALS + TV
Sbjct: 896 FSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGK 955
Query: 443 EEGEAQKFREKLQE-IKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSS 501
E + +L++ KT QK + ++ I + Y GG L+++ +
Sbjct: 956 ERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRY-GGYLISNEGLHF 1014
Query: 502 GNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPL---- 557
+ + + A+ S P KA S+ + F+ LDR P P +
Sbjct: 1015 SYVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDRQP---PISVYNTAGEKW 1071
Query: 558 -HLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQ 616
+ +G + F D F YP+RPD VL GL+ ++ PG+ A VG +G GKST LL+ Y
Sbjct: 1072 DNFQGKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYD 1131
Query: 617 PTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG-LTQKPTMEEITAA 675
P G++++DG + ++L + V QEP +F S+ +NI YG T++ ME + AA
Sbjct: 1132 PDQGKVMIDGHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAA 1191
Query: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
A ++ H F+ LP+ Y+T V GSQLS G++Q +A+ARA++R P +L+LD+ATSALD
Sbjct: 1192 AKQAQLHDFVMSLPEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDT 1251
Query: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
S+ V+ L ++ R R+ ++I LS ++ AD I + G + E GTH++LM +KG
Sbjct: 1252 ESEKTVQVALDKA--REGRTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGA 1309
Query: 796 YWAMV 800
Y+ +V
Sbjct: 1310 YYKLV 1314
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 241 bits (616), Expect = 1e-63
Identities = 173/567 (30%), Positives = 292/567 (51%), Gaps = 18/567 (3%)
Query: 250 FLVLVVLSS-LGEMAIPFFTGRLTDWILQDGSAD--TFTRNLTLMSILTIASAVLEFVG- 305
F+VL L+S L P F+ I G+ D T + + S++ + V+ FV
Sbjct: 246 FVVLGTLASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYSMIFVILGVICFVSY 305
Query: 306 --DGIYNNTMGHVHS-HLQGEVFGAVLRQETEFF--QQNQTGNIMSRVTEDTSTLSDSLS 360
G++ G + + L+ F A+L Q+ +F ++N TG + + + D + + +
Sbjct: 306 FMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATG 365
Query: 361 ENLSLFLWYLVR-GLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRES 419
+ + GL ++ ++G +T + L P+L + + ++
Sbjct: 366 SRIGVLTQNATNMGLSVIISFIYGW-EMTFLILSIAPVLAVTGMIETAAMTGFANKDKQE 424
Query: 420 LAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQ-EIKTLNQKEAVAYAVNSWTTSIS 478
L + ++A EAL + T+ S E+ Q + E LQ + + ++K + + +++ +
Sbjct: 425 LKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFI 484
Query: 479 GMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKI 538
G + G L+ +G ++ + A+ L + P KA + +
Sbjct: 485 YFAYAAGFRF-GAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHL 543
Query: 539 FEYLDRTPRCPPSGL--LTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTAL 596
F L++ P P EG ++F++VSF YP RPDV +L+GL+ ++ G+ A
Sbjct: 544 FALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAF 603
Query: 597 VGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQ 656
VG +G GKST LLQ LY P GQ+L DG + ++L Q+A V QEP +F S+
Sbjct: 604 VGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIA 663
Query: 657 ENIAYGLTQKPT-MEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALAR 715
ENIAYG + ++EI AA + HSFI GLP+ Y+T+V G+QLSGGQ+Q +A+AR
Sbjct: 664 ENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIAR 723
Query: 716 ALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFL 775
AL++KP +L+LD+ATSALD +S+ V+ L ++ R R+ L++T LS ++ AD I+ L
Sbjct: 724 ALLQKPKILLLDEATSALDNDSEKVVQHALDKA--RTGRTCLVVTHRLSAIQNADLIVVL 781
Query: 776 EGGAIREGGTHQQLMEKKGCYWAMVQA 802
G I+E GTHQ+L+ + Y+ +V A
Sbjct: 782 HNGKIKEQGTHQELLRNRDIYFKLVNA 808
Score = 128 bits (321), Expect = 2e-29
Identities = 68/180 (37%), Positives = 110/180 (61%), Gaps = 3/180 (1%)
Query: 623 LLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAH 682
++D + R+ + V QEP +FG ++ NI YG T EE+ AA ++ A+
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYG-RDDVTDEEMERAAREANAY 59
Query: 683 SFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVE 742
FI P ++T V E G+Q+SGGQ+Q +A+ARAL+R P +LILD+ATSALD+ S+ V+
Sbjct: 60 DFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQ 119
Query: 743 QLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQA 802
L ++ + R+ +++ LS + AD I+ L+ G + E G H +LM K+G Y+++V +
Sbjct: 120 AALEKASK--GRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMS 177
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 188 bits (477), Expect = 2e-47
Identities = 132/479 (27%), Positives = 242/479 (50%), Gaps = 20/479 (4%)
Query: 340 QTGNIMSRVTEDTSTLSDSLSE---NLSLFLWYLVRGLCLLGIML--WGSVSLTMVTLIT 394
+TG ++ TS+++ LS N+ L ++ G+ + W + + + +
Sbjct: 365 RTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLY 424
Query: 395 LPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKL 454
L L ++ + K+ + + Q + A+ A+++L TV+ + E E +++RE +
Sbjct: 425 LTLTIVVTEWRTKFRRAMNTQENATRAR----AVDSLLNFETVKYYNAESYEVERYREAI 480
Query: 455 QEIKTLNQKEAVAYAVNSWTTS-ISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQ 513
+ + L K + + + + T + + G+ L G L + VT + G+ V F Y +Q
Sbjct: 481 IKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSL-LCAYFVTEQKLQVGDYVLFGTYIIQ 539
Query: 514 FTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLE-GLVQFQDVSFAY 572
+ + Y +Q E +F+ L PL + G ++F++V F+Y
Sbjct: 540 LYMPLNWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSY 599
Query: 573 PNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQY 632
+ + L Q ++FT+ PG+ ALVGP+G+GKST+ LL Y + G + +DG+ + Q
Sbjct: 600 ADGRETL--QDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQV 657
Query: 633 EHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGY 692
L + V Q+ +F ++ +NI YG +E+ AAA +G H I P+GY
Sbjct: 658 TQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGN-DEVEAAAQAAGIHDAIMAFPEGY 716
Query: 693 DTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERY 752
T+V E G +LSGG++Q VA+AR +++ P +++LD+ATSALD +++ ++ L +
Sbjct: 717 RTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQASL--AKVCA 774
Query: 753 SRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCY---WAMVQAPADAPE 808
+R+ +++ LS V AD IL ++ G I E G H+ L+ + G Y W + Q + E
Sbjct: 775 NRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQQGQEETSE 833
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 186 bits (471), Expect = 1e-46
Identities = 142/520 (27%), Positives = 250/520 (48%), Gaps = 30/520 (5%)
Query: 292 SILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQN------------ 339
++ T+A+AVL +G G+ + + ++ VFG V + +N
Sbjct: 185 TVATMATAVL--IGYGV-SRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGF 241
Query: 340 ----QTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWG-SVSLTMVTLIT 394
QTG + + T +S LS + L + + + G++ + +VTL T
Sbjct: 242 HLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGT 301
Query: 395 LPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKL 454
L V +W +++ ++ + AI++L TV+ F NE EAQ++ L
Sbjct: 302 LGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQRYDGFL 361
Query: 455 QEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQF 514
+ +T + K A+ ++ S + I+ + Q + +G ++ G+LV Q
Sbjct: 362 KTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVNGLLFQL 421
Query: 515 TQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLE---GLVQFQDVSFA 571
+ + L ++Y ++A+ +F L + + +PL + V F +V F
Sbjct: 422 SLPLNFLGTVYRETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFE 481
Query: 572 YPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQ 631
Y VL G++F + G+ A+VG +GSGKST+ LL Y+P G + L G+ +
Sbjct: 482 YIEGQKVL--SGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQD 539
Query: 632 YEHRYLHRQVAAVGQEPQVFGRSLQENIAYG-LTQKPTMEEITAAAVKSGAHSFISGLPQ 690
L R V V Q+ +F ++ N+ YG ++ P EE+ A A +G H I +P
Sbjct: 540 VSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASP--EEVYAVAKLAGLHDAILRMPH 597
Query: 691 GYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPE 750
GYDT+V E G +LSGG++Q VA+ARA+++ P V++ D+ATS+LD+ ++ + + + +
Sbjct: 598 GYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVK 657
Query: 751 RYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLM 790
R+ + I LS V AD I+ L+ G + E GTH L+
Sbjct: 658 H--RTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLL 695
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 164 bits (414), Expect = 4e-40
Identities = 140/486 (28%), Positives = 245/486 (50%), Gaps = 27/486 (5%)
Query: 328 VLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSL 387
V+R FF++ G++++R +++T T+ + + L L Y LL + L +V+
Sbjct: 837 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMY---AFGLLEVSLVVAVAT 893
Query: 388 TMVTLITLPLLFLLPKKVGKWYQLLEVQVR--ESLAKSSQVA--IEALSAMPTVRSFANE 443
+ T+ LPL FLL Y + Q+R ES + SS + E VR+F +
Sbjct: 894 PLATVAILPL-FLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQ 952
Query: 444 EGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQL-VTSGAVSSG 502
+ ++ E + ++ VA + W + + LL G+++ V S A S
Sbjct: 953 APFVAQNNARVDESQRISFPRLVA---DRWLAA-NVELLGNGLVFAAATCAVLSKAHLSA 1008
Query: 503 NLVTF-VLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLT-----P 556
LV F V +Q TQ ++ ++ + ++ ++ S E++ +Y TP+ P L T P
Sbjct: 1009 GLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYA-WTPKEAPWRLPTCAAQPP 1067
Query: 557 LHLEGLVQFQDVSFAYPNRPDV-LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 615
G ++FQD Y RP++ L +QG++F + GE +VG G+GKS++A+ L L
Sbjct: 1068 WPQGGQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQ 1125
Query: 616 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 675
+ G + +DG P+ L +++ + Q+P +F SL+ N+ L Q+ + E I AA
Sbjct: 1126 EAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL--DLLQEHSDEAIWAA 1183
Query: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
+ ++ LP + + G LS GQ+Q + LARAL+RK +LILD+AT+A+D
Sbjct: 1184 LETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDP 1243
Query: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
++LQ++ +L +VLLI L V +L ++ G + E G+ QL+ +KG
Sbjct: 1244 GTELQMQAML--GSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGL 1301
Query: 796 YWAMVQ 801
++ + Q
Sbjct: 1302 FYRLAQ 1307
Score = 119 bits (299), Expect = 9e-27
Identities = 137/540 (25%), Positives = 250/540 (46%), Gaps = 49/540 (9%)
Query: 290 LMSILTIASAVLE--FVGDGIYNNTM--GHVHSHLQGEVFGAVLRQETEFFQQNQTGNIM 345
L+++L SA L+ F +Y + + S + G V+ VL + + + G+++
Sbjct: 160 LLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVV 219
Query: 346 SRVTEDTSTLSDSLSENLSLFL---WYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLP 402
+ V+ D L++S+ L+L W +V + L ++ +++ V L LPL F +
Sbjct: 220 NLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFIS 279
Query: 403 KKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKL-----QEI 457
KK +Q +++ ++S A+ + L T++ F EG F +++ QE+
Sbjct: 280 KKRNH-HQEEQMRQKDSRARLTS---SILRNSKTIK-FHGWEGA---FLDRVLGIRGQEL 331
Query: 458 KTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQA 517
L + + ++V+ + +S L+ + + + + + + VT + +
Sbjct: 332 GAL-RTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQ 390
Query: 518 VEVLLSIYPRVQKAVGSSEKIFEYL---DRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPN 574
+ SI+ VQ V S +++ +L + P S + + Q +FA+ +
Sbjct: 391 AFLPFSIHSLVQARV-SFDRLVTFLCLEEVDPGAVDSSSSGSAAGKDCITIQSATFAW-S 448
Query: 575 RPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEH 634
+ L + T+ G + A+VGP G+GKS++ + L G + ++G
Sbjct: 449 QESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------- 501
Query: 635 RYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEE--ITAAAVKSGAHSFISGLPQGY 692
VA V QE V S+ EN+ +G P E + A A++ SF P+G
Sbjct: 502 ------VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSF----PEGI 551
Query: 693 DTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDAN-SQLQVEQLLYESPER 751
T + E G LSGGQ+Q ++LARA+ RK V +LDD +ALDA+ Q Q++
Sbjct: 552 HTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLL 611
Query: 752 YSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKG---CYWAMVQAPADAPE 808
+ +L+T L ++ QAD I+ L GAI E G++Q+L+++KG C + P D E
Sbjct: 612 QGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGE 671
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 162 bits (410), Expect = 1e-39
Identities = 139/486 (28%), Positives = 245/486 (50%), Gaps = 27/486 (5%)
Query: 328 VLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSL 387
V+R FF++ G++++R +++T T+ + + L L Y LL + L +V+
Sbjct: 1028 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMY---AFGLLEVSLVVAVAT 1084
Query: 388 TMVTLITLPLLFLLPKKVGKWYQLLEVQVR--ESLAKSSQVA--IEALSAMPTVRSFANE 443
+ T+ LPL FLL Y + Q+R ES + SS + E VR+F +
Sbjct: 1085 PLATVAILPL-FLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQ 1143
Query: 444 EGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQL-VTSGAVSSG 502
+ ++ E + ++ VA + W + + LL G+++ V S A S
Sbjct: 1144 APFVAQNNARVDESQRISFPRLVA---DRWLAA-NVELLGNGLVFAAATCAVLSKAHLSA 1199
Query: 503 NLVTF-VLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLT-----P 556
LV F V +Q TQ ++ ++ + ++ ++ S E++ +Y TP+ P L T P
Sbjct: 1200 GLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYA-WTPKEAPWRLPTCAAQPP 1258
Query: 557 LHLEGLVQFQDVSFAYPNRPDV-LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLY 615
G ++F+D Y RP++ L +QG++F + GE +VG G+GKS++A+ L L
Sbjct: 1259 WPQGGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQ 1316
Query: 616 QPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAA 675
+ G + +DG P+ L +++ + Q+P +F SL+ N+ L Q+ + E I AA
Sbjct: 1317 EAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL--DLLQEHSDEAIWAA 1374
Query: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735
+ ++ LP + + G LS GQ+Q + LARAL+RK +LILD+AT+A+D
Sbjct: 1375 LETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDP 1434
Query: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC 795
++LQ++ +L +VLLI L V +L ++ G + E G+ QL+ +KG
Sbjct: 1435 GTELQMQAML--GSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGL 1492
Query: 796 YWAMVQ 801
++ + Q
Sbjct: 1493 FYRLAQ 1498
Score = 117 bits (293), Expect = 4e-26
Identities = 136/540 (25%), Positives = 249/540 (46%), Gaps = 49/540 (9%)
Query: 290 LMSILTIASAVLE--FVGDGIYNNTM--GHVHSHLQGEVFGAVLRQETEFFQQNQTGNIM 345
L+++L SA L+ F +Y + + S + G V+ VL + + + G+++
Sbjct: 351 LLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYRKVLALSSGSRKASAVGDVV 410
Query: 346 SRVTEDTSTLSDSLSENLSLFL---WYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLP 402
+ V+ D L++S+ L+L W +V + L ++ +++ V L LPL F +
Sbjct: 411 NLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFFIS 470
Query: 403 KKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKL-----QEI 457
KK +Q +++ ++S A+ + L T++ F EG F +++ QE+
Sbjct: 471 KKRNH-HQEEQMRQKDSRARLTS---SILRNSKTIK-FHGWEGA---FLDRVLGIRGQEL 522
Query: 458 KTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQA 517
L + + ++V+ + +S L+ + + + + + + VT + +
Sbjct: 523 GAL-RTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQ 581
Query: 518 VEVLLSIYPRVQKAVGSSEKIFEYL---DRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPN 574
+ SI+ VQ V S +++ +L + P S + + +FA+ +
Sbjct: 582 AFLPFSIHSLVQARV-SFDRLVTFLCLEEVDPGVVDSSSSGSAAGKDCITIHSATFAW-S 639
Query: 575 RPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEH 634
+ L + T+ G + A+VGP G+GKS++ + L G + ++G
Sbjct: 640 QESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------- 692
Query: 635 RYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEE--ITAAAVKSGAHSFISGLPQGY 692
VA V QE V S+ EN+ +G P E + A A++ SF P+G
Sbjct: 693 ------VAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDVDSF----PEGI 742
Query: 693 DTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDAN-SQLQVEQLLYESPER 751
T + E G LSGGQ+Q ++LARA+ RK V +LDD +ALDA+ Q Q++
Sbjct: 743 HTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLL 802
Query: 752 YSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKG---CYWAMVQAPADAPE 808
+ +L+T L ++ QAD I+ L GAI E G++Q+L+++KG C + P D E
Sbjct: 803 QGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQARQPGDRGE 862
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 159 bits (402), Expect = 1e-38
Identities = 140/527 (26%), Positives = 256/527 (48%), Gaps = 42/527 (7%)
Query: 294 LTIASAVLEFVGDGIYNNTMGHVHSH--LQGEVFGAVLRQETEFFQQNQTGNIMSRVTED 351
L +A + F+ + + G VH+ L ++ +LR FF TG I++R D
Sbjct: 1030 LGLAQGIFVFIAH--FWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFAGD 1087
Query: 352 TSTLSDSLSENLSLFLWYLVRGLCLLGI---MLWGSVSLTMVTLITLPLLFLLPKKVGKW 408
ST+ D+L ++L ++ C LGI ++ ++ + T+I +PL ++ V +
Sbjct: 1088 ISTVDDTLPQSLRSWI------TCFLGIISTLVMICMATPVFTIIVIPL-GIIYVSVQMF 1140
Query: 409 YQLLEVQVR--ESLAKSSQVA--IEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKE 464
Y Q+R +S+ +S + E +S +P +R+F ++ Q+F + + NQK
Sbjct: 1141 YVSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQ----QRFLKHNEVRIDTNQKC 1196
Query: 465 AVAYAV-NSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQ-MQFTQAVEVLL 522
++ N W ++ + + + +V SG+ V FVL + TQ + L+
Sbjct: 1197 VFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLV 1256
Query: 523 SIYPRVQKAVGSSEKIFEYLDR-------TPRCPPSGLLTPLHLEGLVQFQDVSFAYPNR 575
+ ++ + + E+I EY T + PP + +G +QF + Y R
Sbjct: 1257 RMTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPS----KGKIQFNNYQVRY--R 1310
Query: 576 PDV-LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEH 634
P++ LVL+G+T + E +VG G+GKS++ L + + GGQ+++DG +
Sbjct: 1311 PELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGL 1370
Query: 635 RYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDT 694
L ++ + Q+P +F SL+ N+ + EEI A + SF++ L G
Sbjct: 1371 HDLREKLTIIPQDPILFSGSLRMNL--DPFNNYSDEEIWKALELAHLKSFVASLQLGLSH 1428
Query: 695 EVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSR 754
EV EAG LS GQRQ + L RAL+RK +L+LD+AT+A+D + ++ + E
Sbjct: 1429 EVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQN--EFAHC 1486
Query: 755 SVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
+V+ I L + +D ++ L+ G I E G+ ++L++ G ++ M +
Sbjct: 1487 TVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFMAK 1533
Score = 102 bits (254), Expect = 1e-21
Identities = 106/491 (21%), Positives = 220/491 (44%), Gaps = 41/491 (8%)
Query: 316 VHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLC 375
V + + V+ L ++ G ++ ++ D L D N LW V +
Sbjct: 392 VRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVT--NFMHMLWSSVLQIV 449
Query: 376 LLGIMLWGSVSLTM-----VTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEA 430
L LW + ++ V ++ +P+ +L K + ++V+ ++ K ++ E
Sbjct: 450 LSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKS----KTIQVKNMKNKDKRLKIMNEI 505
Query: 431 LSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYA----VNSWTTSISGMLLKVGI 486
LS + ++ FA E FR+++Q ++ K +A++ V + ++ +L+ V
Sbjct: 506 LSGIKILKYFAWEPS----FRDQVQNLRKKELKNLLAFSQLQCVVIFVFQLTPVLVSVVT 561
Query: 487 LYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTP 546
+ + ++ + + T + + +L + + +A S+E++ +YL
Sbjct: 562 FSVYVLVDSNNILDAQKAFTSITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGDD 621
Query: 547 RCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKST 606
S + + + +QF + SF + + + V + + + G++ A++GP GSGKS+
Sbjct: 622 -LDTSAIRHDCNFDKAMQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSS 679
Query: 607 VAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYG--LT 664
+ + + + G + + G A V Q+ + ++++NI +G
Sbjct: 680 LISAMLGEMENVHGHITIKGT-------------TAYVPQQSWIQNGTIKDNILFGTEFN 726
Query: 665 QKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVL 724
+K + + A A+ + LP G E+ E G LSGGQ+Q ++LARA + +
Sbjct: 727 EKRYQQVLEACALLPD----LEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIY 782
Query: 725 ILDDATSALDANSQLQV-EQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREG 783
+LDD SA+DA+ + ++L + ++ LL+T + + Q D I+ L G I E
Sbjct: 783 LLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEK 842
Query: 784 GTHQQLMEKKG 794
G++ L+ KKG
Sbjct: 843 GSYSALLAKKG 853
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 154 bits (389), Expect = 3e-37
Identities = 153/551 (27%), Positives = 255/551 (46%), Gaps = 37/551 (6%)
Query: 247 LSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSAD------TFTRNLTLMSILTIASAV 300
+ LF ++L S G + IP F +GS+D + + S+ T+ AV
Sbjct: 903 MGLFSPQLLLFSPGNLYIPVFP---LPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAV 959
Query: 301 LEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLS 360
L G T+ + L + VL FF TG I++R + D + DSL
Sbjct: 960 LFAAG------TL-QAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLP 1012
Query: 361 ENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESL 420
L++ L L LL ++ G L L+ LP L ++ V + Y+ ++R
Sbjct: 1013 FILNILLANAAGLLGLLAVLGSGLPWL----LLLLPPLSIMYYHVQRHYRASSRELRRLG 1068
Query: 421 AKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGM 480
+ + L+ S G +F E+ + LNQ+ A + I
Sbjct: 1069 SLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQ 1128
Query: 481 LLKVGIL--YIGGQLVT--SGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSE 536
L+ ++ G LV G + G + + Y + T + L+S + + + + S E
Sbjct: 1129 LMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVE 1188
Query: 537 KIFEY---LDRTPRCPPSGLLTPLHLEGLVQFQDVSFAY-PNRPDVLVLQGLTFTLRPGE 592
++ EY L + P+ P L T +G V+FQDV AY P P+ L G+TF ++PGE
Sbjct: 1189 RLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNAL--DGVTFCVQPGE 1246
Query: 593 VTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFG 652
+VG GSGKS++ +L L +P+ G++LLDG Q E L Q+A + QEP +F
Sbjct: 1247 KLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFS 1306
Query: 653 RSLQENI-AYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAV 711
+++EN+ GL + + + A+K S + G D E+ E G LS GQRQ +
Sbjct: 1307 GTVRENLDPQGLHKDRALWQ----ALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLL 1362
Query: 712 ALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADH 771
LARAL+ +L +D+AT+++D + ++Q + + +++VL I L+ + +D
Sbjct: 1363 CLARALLTDAKILCIDEATASVDQKTDQLLQQTICK--RFANKTVLTIAHRLNTILNSDR 1420
Query: 772 ILFLEGGAIRE 782
+L L+ G + E
Sbjct: 1421 VLVLQAGRVVE 1431
Score = 73.9 bits (180), Expect = 5e-13
Identities = 58/205 (28%), Positives = 98/205 (47%), Gaps = 17/205 (8%)
Query: 588 LRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQE 647
++ G + +VG G GKS++ A + G + + G L + QE
Sbjct: 595 VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQE 644
Query: 648 PQVFGRSLQENIAYGLTQKPTM--EEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSG 705
P + ++++NI +G T + E + A A+ +S LP G TEV E G LSG
Sbjct: 645 PWIQFATIRDNILFGKTFDAQLYKEVLEACALNDD----LSILPAGDQTEVGEKGVTLSG 700
Query: 706 GQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSL 765
GQR +ALARA+ ++ + +LDD +A+DA+ + Y+ + LL T
Sbjct: 701 GQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYT-TRLLCTHRTEY 759
Query: 766 VEQADHILFLEGGAIREGGTHQQLM 790
+E+AD +L +E G + G +++
Sbjct: 760 LERADAVLLMEAGRLIRAGPPSEIL 784
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 148 bits (374), Expect = 2e-35
Identities = 135/570 (23%), Positives = 273/570 (47%), Gaps = 35/570 (6%)
Query: 247 LSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGD 306
LS+FL + + + +A ++ TD + +G+ + L++ L I+ + F G
Sbjct: 921 LSIFLFMC--NHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF-GY 977
Query: 307 GIYNNTMGHVHSH-LQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL 365
+ + G + S L ++ ++LR FF++ +GN+++R +++ T+ + E + +
Sbjct: 978 SMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKM 1037
Query: 366 FLWYL--VRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVR--ESLA 421
F+ L V G C++ ++ T + I +P L L+ V ++Y Q++ ES++
Sbjct: 1038 FMGSLFNVIGACIVILLA------TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVS 1091
Query: 422 KSSQVAI--EALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTT---- 475
+S + E L + +R+F +E + K+ E + VA N W
Sbjct: 1092 RSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA---NRWLAVRLE 1148
Query: 476 SISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSS 535
+ ++ L+ +++ ++S+G + V Y +Q T + L+ + ++ + +
Sbjct: 1149 CVGNCIVLFAALFA---VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAV 1205
Query: 536 EKIFEYLDRTPRCP----PSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPG 591
E++ EY + P + + G V+F++ Y D VL+ + T+ G
Sbjct: 1206 ERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLD-FVLRHINVTINGG 1264
Query: 592 EVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVF 651
E +VG G+GKS++ L + + G++++DG + + L ++ + Q+P +F
Sbjct: 1265 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1324
Query: 652 GRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAV 711
SL+ N+ + + EE+ + + F+S LP D E E G LS GQRQ V
Sbjct: 1325 SGSLRMNL--DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV 1382
Query: 712 ALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADH 771
LARAL+RK +L+LD+AT+A+D + ++ + E +VL I L+ +
Sbjct: 1383 CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE--DCTVLTIAHRLNTIMDYTR 1440
Query: 772 ILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
++ L+ G I+E G L++++G +++M +
Sbjct: 1441 VIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1470
Score = 46.6 bits (109), Expect = 9e-05
Identities = 96/502 (19%), Positives = 199/502 (39%), Gaps = 93/502 (18%)
Query: 324 VFGAVLRQE---TEFFQQNQT-GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGI 379
V GAV R+ T +++ T G I++ ++ D D L+ +++ +W + L
Sbjct: 399 VIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD-LATYINM-IWSAPLQVILALY 456
Query: 380 MLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAI--EALSAMPTV 437
+LW ++ +++ + + +L ++P + QV +K +++ + E L+ + +
Sbjct: 457 LLWLNLGPSVLAGVAVMVL-MVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVL 515
Query: 438 RSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSG 497
+ +A E K QE + +K A AV ++T + L+ + + + +
Sbjct: 516 KLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN 575
Query: 498 AVSSGN-LVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTP 556
+ + V+ L+ + + +L + + +A S +++ +L P S P
Sbjct: 576 ILDAQTAFVSLALFNI-LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRP 634
Query: 557 LHLEG---LVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQN 613
+ G + ++ +F + R D L G+TF++ G + A+VG G GKS++ + L
Sbjct: 635 VKDGGGTNSITVRNATFTWA-RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLA 693
Query: 614 LYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGL-TQKPTMEEI 672
G + + G VA V Q+ + SL+ENI +G ++P +
Sbjct: 694 EMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV 740
Query: 673 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 732
A LP D E+ +G + G++ + + +
Sbjct: 741 IQACAL---------LP---DLEILPSGDRTEIGEKTRILVTHS---------------- 772
Query: 733 LDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
+S + Q D I+ + GG I E G++Q+L+ +
Sbjct: 773 ------------------------------MSYLPQVDVIIVMSGGKISEMGSYQELLAR 802
Query: 793 KGCY------WAMVQAPADAPE 808
G + +A + DA E
Sbjct: 803 DGAFAEFLRTYASTEQEQDAEE 824
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 148 bits (374), Expect = 2e-35
Identities = 135/570 (23%), Positives = 273/570 (47%), Gaps = 35/570 (6%)
Query: 247 LSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGD 306
LS+FL + + + +A ++ TD + +G+ + L++ L I+ + F G
Sbjct: 862 LSIFLFMC--NHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF-GY 918
Query: 307 GIYNNTMGHVHSH-LQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL 365
+ + G + S L ++ ++LR FF++ +GN+++R +++ T+ + E + +
Sbjct: 919 SMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKM 978
Query: 366 FLWYL--VRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVR--ESLA 421
F+ L V G C++ ++ T + I +P L L+ V ++Y Q++ ES++
Sbjct: 979 FMGSLFNVIGACIVILLA------TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVS 1032
Query: 422 KSSQVAI--EALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTT---- 475
+S + E L + +R+F +E + K+ E + VA N W
Sbjct: 1033 RSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA---NRWLAVRLE 1089
Query: 476 SISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSS 535
+ ++ L+ +++ ++S+G + V Y +Q T + L+ + ++ + +
Sbjct: 1090 CVGNCIVLFAALFA---VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAV 1146
Query: 536 EKIFEYLDRTPRCP----PSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPG 591
E++ EY + P + + G V+F++ Y D VL+ + T+ G
Sbjct: 1147 ERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLD-FVLRHINVTINGG 1205
Query: 592 EVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVF 651
E +VG G+GKS++ L + + G++++DG + + L ++ + Q+P +F
Sbjct: 1206 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1265
Query: 652 GRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAV 711
SL+ N+ + + EE+ + + F+S LP D E E G LS GQRQ V
Sbjct: 1266 SGSLRMNL--DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV 1323
Query: 712 ALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADH 771
LARAL+RK +L+LD+AT+A+D + ++ + E +VL I L+ +
Sbjct: 1324 CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE--DCTVLTIAHRLNTIMDYTR 1381
Query: 772 ILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
++ L+ G I+E G L++++G +++M +
Sbjct: 1382 VIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1411
Score = 37.7 bits (86), Expect = 0.043
Identities = 64/324 (19%), Positives = 142/324 (43%), Gaps = 15/324 (4%)
Query: 324 VFGAVLRQE---TEFFQQNQT-GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGI 379
V GAV R+ T +++ T G I++ ++ D D L+ +++ +W + L
Sbjct: 399 VIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD-LATYINM-IWSAPLQVILALY 456
Query: 380 MLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAI--EALSAMPTV 437
+LW ++ +++ + + +L ++P + QV +K +++ + E L+ + +
Sbjct: 457 LLWLNLGPSVLAGVAVMVL-MVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVL 515
Query: 438 RSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSG 497
+ +A E K QE + +K A AV ++T + L+ + + + +
Sbjct: 516 KLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN 575
Query: 498 AVSSGN-LVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTP 556
+ + V+ L+ + + +L + + +A S +++ +L P S P
Sbjct: 576 ILDAQTAFVSLALFNI-LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRP 634
Query: 557 LHLEG---LVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQN 613
+ G + ++ +F + R D L G+TF++ G + A+VG G GKS++ + L
Sbjct: 635 VKDGGGTNSITVRNATFTWA-RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLA 693
Query: 614 LYQPTGGQLLLDGKPLPQYEHRYL 637
G + + + L + YL
Sbjct: 694 EMDKVEGHVAIKTRILVTHSMSYL 717
Score = 35.8 bits (81), Expect = 0.16
Identities = 18/58 (31%), Positives = 32/58 (55%), Gaps = 6/58 (10%)
Query: 757 LLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCY------WAMVQAPADAPE 808
+L+T +S + Q D I+ + GG I E G++Q+L+ + G + +A + DA E
Sbjct: 708 ILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEE 765
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 148 bits (374), Expect = 2e-35
Identities = 135/570 (23%), Positives = 273/570 (47%), Gaps = 35/570 (6%)
Query: 247 LSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGD 306
LS+FL + + + +A ++ TD + +G+ + L++ L I+ + F G
Sbjct: 918 LSIFLFMC--NHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF-GY 974
Query: 307 GIYNNTMGHVHSH-LQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL 365
+ + G + S L ++ ++LR FF++ +GN+++R +++ T+ + E + +
Sbjct: 975 SMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKM 1034
Query: 366 FLWYL--VRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVR--ESLA 421
F+ L V G C++ ++ T + I +P L L+ V ++Y Q++ ES++
Sbjct: 1035 FMGSLFNVIGACIVILLA------TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVS 1088
Query: 422 KSSQVAI--EALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTT---- 475
+S + E L + +R+F +E + K+ E + VA N W
Sbjct: 1089 RSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA---NRWLAVRLE 1145
Query: 476 SISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSS 535
+ ++ L+ +++ ++S+G + V Y +Q T + L+ + ++ + +
Sbjct: 1146 CVGNCIVLFAALFA---VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAV 1202
Query: 536 EKIFEYLDRTPRCP----PSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPG 591
E++ EY + P + + G V+F++ Y D VL+ + T+ G
Sbjct: 1203 ERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLD-FVLRHINVTINGG 1261
Query: 592 EVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVF 651
E +VG G+GKS++ L + + G++++DG + + L ++ + Q+P +F
Sbjct: 1262 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1321
Query: 652 GRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAV 711
SL+ N+ + + EE+ + + F+S LP D E E G LS GQRQ V
Sbjct: 1322 SGSLRMNL--DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV 1379
Query: 712 ALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADH 771
LARAL+RK +L+LD+AT+A+D + ++ + E +VL I L+ +
Sbjct: 1380 CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE--DCTVLTIAHRLNTIMDYTR 1437
Query: 772 ILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
++ L+ G I+E G L++++G +++M +
Sbjct: 1438 VIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1467
Score = 62.4 bits (150), Expect = 2e-09
Identities = 44/142 (30%), Positives = 72/142 (50%), Gaps = 10/142 (7%)
Query: 677 VKSGAHSFISGLPQGYDT---EVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSAL 733
V G S +S L D V G LSGGQ+Q V+LARA+ + + DD SA+
Sbjct: 680 VGCGKSSLLSALLAEMDKVEGHVAIKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAV 739
Query: 734 DANSQLQV-EQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
DA+ + E ++ +++ +L+T +S + Q D I+ + GG I E G++Q+L+ +
Sbjct: 740 DAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 799
Query: 793 KGCY------WAMVQAPADAPE 808
G + +A + DA E
Sbjct: 800 DGAFAEFLRTYASTEQEQDAEE 821
Score = 37.0 bits (84), Expect = 0.073
Identities = 62/313 (19%), Positives = 138/313 (44%), Gaps = 15/313 (4%)
Query: 324 VFGAVLRQE---TEFFQQNQT-GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGI 379
V GAV R+ T +++ T G I++ ++ D D L+ +++ +W + L
Sbjct: 399 VIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD-LATYINM-IWSAPLQVILALY 456
Query: 380 MLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAI--EALSAMPTV 437
+LW ++ +++ + + +L ++P + QV +K +++ + E L+ + +
Sbjct: 457 LLWLNLGPSVLAGVAVMVL-MVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVL 515
Query: 438 RSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSG 497
+ +A E K QE + +K A AV ++T + L+ + + + +
Sbjct: 516 KLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN 575
Query: 498 AVSSGN-LVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTP 556
+ + V+ L+ + + +L + + +A S +++ +L P S P
Sbjct: 576 ILDAQTAFVSLALFNI-LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRP 634
Query: 557 LHLEG---LVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQN 613
+ G + ++ +F + R D L G+TF++ G + A+VG G GKS++ + L
Sbjct: 635 VKDGGGTNSITVRNATFTWA-RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLA 693
Query: 614 LYQPTGGQLLLDG 626
G + + G
Sbjct: 694 EMDKVEGHVAIKG 706
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 148 bits (374), Expect = 2e-35
Identities = 135/570 (23%), Positives = 273/570 (47%), Gaps = 35/570 (6%)
Query: 247 LSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGD 306
LS+FL + + + +A ++ TD + +G+ + L++ L I+ + F G
Sbjct: 977 LSIFLFMC--NHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVF-GY 1033
Query: 307 GIYNNTMGHVHSH-LQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSL 365
+ + G + S L ++ ++LR FF++ +GN+++R +++ T+ + E + +
Sbjct: 1034 SMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKM 1093
Query: 366 FLWYL--VRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVR--ESLA 421
F+ L V G C++ ++ T + I +P L L+ V ++Y Q++ ES++
Sbjct: 1094 FMGSLFNVIGACIVILLA------TPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVS 1147
Query: 422 KSSQVAI--EALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTT---- 475
+S + E L + +R+F +E + K+ E + VA N W
Sbjct: 1148 RSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVA---NRWLAVRLE 1204
Query: 476 SISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSS 535
+ ++ L+ +++ ++S+G + V Y +Q T + L+ + ++ + +
Sbjct: 1205 CVGNCIVLFAALFA---VISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAV 1261
Query: 536 EKIFEYLDRTPRCP----PSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPG 591
E++ EY + P + + G V+F++ Y D VL+ + T+ G
Sbjct: 1262 ERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLD-FVLRHINVTINGG 1320
Query: 592 EVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVF 651
E +VG G+GKS++ L + + G++++DG + + L ++ + Q+P +F
Sbjct: 1321 EKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLF 1380
Query: 652 GRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAV 711
SL+ N+ + + EE+ + + F+S LP D E E G LS GQRQ V
Sbjct: 1381 SGSLRMNL--DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLV 1438
Query: 712 ALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADH 771
LARAL+RK +L+LD+AT+A+D + ++ + E +VL I L+ +
Sbjct: 1439 CLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE--DCTVLTIAHRLNTIMDYTR 1496
Query: 772 ILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
++ L+ G I+E G L++++G +++M +
Sbjct: 1497 VIVLDKGEIQEYGAPSDLLQQRGLFYSMAK 1526
Score = 102 bits (253), Expect = 2e-21
Identities = 117/503 (23%), Positives = 229/503 (45%), Gaps = 39/503 (7%)
Query: 324 VFGAVLRQE---TEFFQQNQT-GNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGI 379
V GAV R+ T +++ T G I++ ++ D D L+ +++ +W + L
Sbjct: 399 VIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMD-LATYINM-IWSAPLQVILALY 456
Query: 380 MLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAI--EALSAMPTV 437
+LW ++ +++ + + +L ++P + QV +K +++ + E L+ + +
Sbjct: 457 LLWLNLGPSVLAGVAVMVL-MVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVL 515
Query: 438 RSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSG 497
+ +A E K QE + +K A AV ++T + L+ + + + +
Sbjct: 516 KLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVTIDENN 575
Query: 498 AVSSGN-LVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTP 556
+ + V+ L+ + + +L + + +A S +++ +L P S P
Sbjct: 576 ILDAQTAFVSLALFNI-LRFPLNILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRP 634
Query: 557 LHLEG---LVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQN 613
+ G + ++ +F + R D L G+TF++ G + A+VG G GKS++ + L
Sbjct: 635 VKDGGGTNSITVRNATFTWA-RSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLA 693
Query: 614 LYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLT-QKPTMEEI 672
G + + G VA V Q+ + SL+ENI +G ++P +
Sbjct: 694 EMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFGCQLEEPYYRSV 740
Query: 673 TAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSA 732
A + LP G TE+ E G LSGGQ+Q V+LARA+ + + DD SA
Sbjct: 741 IQACALLPD---LEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSA 797
Query: 733 LDANSQLQV-EQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLME 791
+DA+ + E ++ +++ +L+T +S + Q D I+ + GG I E G++Q+L+
Sbjct: 798 VDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLA 857
Query: 792 KKGCY------WAMVQAPADAPE 808
+ G + +A + DA E
Sbjct: 858 RDGAFAEFLRTYASTEQEQDAEE 880
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 137 bits (345), Expect = 4e-32
Identities = 140/582 (24%), Positives = 263/582 (45%), Gaps = 41/582 (7%)
Query: 250 FLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTR-NLTLMS--------------IL 294
FLV++ L L + F T L+ WI Q T TR N T +S I
Sbjct: 859 FLVIMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIY 918
Query: 295 TIASAV---LEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTED 351
++ AV L+ + ++ S L E+F +LR +FF TG I++R ++D
Sbjct: 919 ALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKD 978
Query: 352 TSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQL 411
+ L +F+ ++ +G M+ G +V + L +LF + V + +
Sbjct: 979 MDEVDVRLPFQAEMFIQNVILVFFCVG-MIAGVFPWFLVAVGPLVILFSVLHIVSR-VLI 1036
Query: 412 LEVQVRESLAKSSQVA--IEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYA 469
E++ +++ +S ++ ++ + T+ ++ + Q+F + QE+ NQ +
Sbjct: 1037 RELKRLDNITQSPFLSHITSSIQGLATIHAY----NKGQEFLHRYQELLDDNQAPFFLFT 1092
Query: 470 VNSWTTSISGMLLKVGILYIGGQLVT--SGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPR 527
++ L+ + ++ G ++ G + + Y +Q T + + +
Sbjct: 1093 CAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASE 1152
Query: 528 VQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHL-----EGLVQFQDVSFAY-PNRPDVLVL 581
+ S E+I Y+ P+ + EG V F++ Y N P LVL
Sbjct: 1153 TEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLP--LVL 1210
Query: 582 QGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQV 641
+ ++FT++P E +VG GSGKS++ L L + +GG + +DG + L ++
Sbjct: 1211 KKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKL 1270
Query: 642 AAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGS 701
+ + QEP +F +++ N+ + T ++I A ++ I+ LP ++EV E G
Sbjct: 1271 SIIPQEPVLFSGTVRSNL--DPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328
Query: 702 QLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQ 761
S G+RQ + +ARAL+R +LILD+AT+A+D + L +++ + E+ ++L I
Sbjct: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREA--FADCTMLTIAH 1386
Query: 762 HLSLVEQADHILFLEGGAIREGGTHQQLMEKKGC-YWAMVQA 802
L V +D I+ L G + E T L+ ++AM A
Sbjct: 1387 RLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAA 1428
Score = 92.0 bits (227), Expect = 2e-18
Identities = 67/220 (30%), Positives = 108/220 (49%), Gaps = 24/220 (10%)
Query: 581 LQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQ 640
L + ++ G++ + G GSGK+++ + + G + + G
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT------------- 624
Query: 641 VAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGA-HSFISGLPQGYDTEVDEA 699
A V Q+ + +L++NI +G K EE + + S ++ LP TE+ E
Sbjct: 625 FAYVAQQAWILNATLRDNILFG---KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 700 GSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPER---YSRSV 756
G+ LSGGQRQ ++LARAL + ILDD SALDA+ V ++ S R S++V
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAH----VGNHIFNSAIRKHLKSKTV 737
Query: 757 LLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCY 796
L +T L + D ++F++ G I E GTH++LM G Y
Sbjct: 738 LFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDY 777
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 136 bits (343), Expect = 7e-32
Identities = 119/494 (24%), Positives = 228/494 (46%), Gaps = 45/494 (9%)
Query: 329 LRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLT 388
+R FF +G I++ ++D + + L+ + + L + L +++ S L
Sbjct: 1053 IRSPQSFFDTTPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTL-VVIMASTPLF 1111
Query: 389 MVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQ 448
V ++ L +L+ L V ++Y Q++ +E++S P F+ A
Sbjct: 1112 TVVILPLAVLYTL---VQRFYAATSRQLKR---------LESVSRSPIYSHFSETVTGAS 1159
Query: 449 KFR--EKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAV------- 499
R + ++ + ++ + A + + IS L +G+ ++G +V A+
Sbjct: 1160 VIRAYNRSRDFEIISDTKVDANQRSCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRS 1219
Query: 500 --SSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCP-------- 549
+ G + V Y +Q T A+ ++ + ++ + + E++ EY P
Sbjct: 1220 SLNPGLVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRP 1279
Query: 550 PSGLLTPLHLEGLVQFQDVSFAYPNRPDV-LVLQGLTFTLRPGEVTALVGPNGSGKSTVA 608
P G G V+F++ S Y RP + LVL+ L+ + GE +VG G+GKS++
Sbjct: 1280 PEGWPP----RGEVEFRNYSVRY--RPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMT 1333
Query: 609 ALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENI-AYGLTQKP 667
L + + G++ +DG + L Q+ + Q+P +F +L+ N+ +G +
Sbjct: 1334 LCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSE- 1392
Query: 668 TMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILD 727
E+I A S H+F+S P G D + E G LS GQRQ V LARAL+RK +L+LD
Sbjct: 1393 --EDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLD 1450
Query: 728 DATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQ 787
+AT+A+D + ++ + + + +VL I L+ + +L L+ G + E +
Sbjct: 1451 EATAAIDLETDNLIQATIRTQFD--TCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPA 1508
Query: 788 QLMEKKGCYWAMVQ 801
L+ +G ++ M +
Sbjct: 1509 NLIAARGIFYGMAR 1522
Score = 99.0 bits (245), Expect = 2e-20
Identities = 108/488 (22%), Positives = 208/488 (42%), Gaps = 38/488 (7%)
Query: 320 LQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGI 379
+ G ++ L + + G I++ ++ D D L+ L+L LW + L
Sbjct: 385 IMGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMD-LAPFLNL-LWSAPLQIILAIY 442
Query: 380 MLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAI--EALSAMPTV 437
LW ++ +++ + +L L+P ++ QV++ K S++ + E L+ + +
Sbjct: 443 FLWQNLGPSVLAGVAFMVL-LIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVL 501
Query: 438 RSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSG 497
+ +A E ++ Q L + A + ++T S L+ + L++ + +
Sbjct: 502 KLYAWEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNN 561
Query: 498 AVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPS------ 551
+ + V + +L + + +A S ++I ++L + P S
Sbjct: 562 VLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTI 621
Query: 552 --GLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAA 609
G +H QD+ L L + G + A+VGP G GKS++ +
Sbjct: 622 SPGYAITIHSGTFTWAQDLP---------PTLHSLDIQVPKGALVAVVGPVGCGKSSLVS 672
Query: 610 LLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTM 669
L + G++ + G VA V Q+ + +LQEN+ +G P
Sbjct: 673 ALLGEMEKLEGKVHMKGS-------------VAYVPQQAWIQNCTLQENVLFGKALNPKR 719
Query: 670 EEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDA 729
+ T A A + LP G TE+ E G LSGGQRQ V+LARA+ + +LDD
Sbjct: 720 YQQTLEACALLAD--LEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDP 777
Query: 730 TSALDANSQLQV-EQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQ 788
SA+D++ + + ++ ++ +L+T +S + Q D I+ L G + E G +
Sbjct: 778 LSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPA 837
Query: 789 LMEKKGCY 796
L+++ G +
Sbjct: 838 LLQRNGSF 845
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 134 bits (336), Expect = 4e-31
Identities = 132/527 (25%), Positives = 250/527 (47%), Gaps = 30/527 (5%)
Query: 288 LTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSR 347
L + S LT+A+ + + + + L ++F ++L+ FF +N G I++R
Sbjct: 765 LGIYSGLTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNR 824
Query: 348 VTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGK 407
++D L D L FL ++ L ++G++ SV++ ++ I +PL+ L +
Sbjct: 825 FSKDIGHLDDLLPLT---FLDFIQTLLQVVGVV---SVAVAVIPWIAIPLVPLGIIFIFL 878
Query: 408 WYQLLE----VQVRESLAKSSQVA--IEALSAMPTVRSFANEEGEAQKFREKLQEIKTLN 461
LE V+ ES +S + +L + T+R++ EE + +E + L+
Sbjct: 879 RRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEE----RCQELFDAHQDLH 934
Query: 462 QKEAVAYAVNS--WTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVE 519
+ + S + + + I+ G L+ + + +G + + Y + +
Sbjct: 935 SEAWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQ 994
Query: 520 VLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHL---EGLVQFQDVSFAY-PNR 575
+ V+ + S E++ EY D P P EG++ F +V+F Y P
Sbjct: 995 WCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFMYSPGG 1054
Query: 576 PDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHR 635
P LVL+ LT ++ E +VG G+GKS++ + L L +P G ++ +D +
Sbjct: 1055 P--LVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEG-KIWIDKILTTEIGLH 1111
Query: 636 YLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTE 695
L ++++ + QEP +F ++++N+ + T EE+ A + I LP DTE
Sbjct: 1112 DLRKKMSIIPQEPVLFTGTMRKNL--DPFNEHTDEELWNALQEVQLKETIEDLPGKMDTE 1169
Query: 696 VDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRS 755
+ E+GS S GQRQ V LARA++RK +LI+D+AT+ +D + +++ + E +
Sbjct: 1170 LAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHC--T 1227
Query: 756 VLLITQHLSLVEQADHILFLEGGAIRE-GGTHQQLMEKKGCYWAMVQ 801
VL I L+ + +D I+ L+ G ++E + L K+ ++ MVQ
Sbjct: 1228 VLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMVQ 1274
Score = 114 bits (286), Expect = 3e-25
Identities = 130/569 (22%), Positives = 249/569 (43%), Gaps = 65/569 (11%)
Query: 250 FLVLVVLSSLGEMAI---PFFTGRLTDWILQDGSADTFTRNL-----TLMSILTIASAVL 301
+LVL + + + E A P F G++ ++ D+ N T+++ T+ A+L
Sbjct: 92 YLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILAIL 151
Query: 302 EFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSE 361
+ + + ++ LR + TG I++ ++ D + +
Sbjct: 152 HHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKF-----D 206
Query: 362 NLSLFLWYLVRG---LCLLGIMLWGSVSLTMVTLITLPLLFLLPKK--VGKWYQLLEVQV 416
+++FL +L G + +LW + ++ + + + L+ LLP + GK + L +
Sbjct: 207 QVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAV-LIILLPLQSCFGKLFSSLRSKT 265
Query: 417 RESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFRE-KLQEIKTLNQKEAVAYAVNSWTT 475
+ E ++ + ++ +A E+ + + +EI + + + + +
Sbjct: 266 ATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKILRSSCLRGM--NLAS 323
Query: 476 SISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSS 535
S + V + + L+ S +S V LY S RV +A+ S
Sbjct: 324 FFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSI 383
Query: 536 EKIFEYL------DRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLR 589
+I +L R + P G + +V QD + + + LQGL+FT+R
Sbjct: 384 RRIQTFLLLDEISQRNRQLPSDG-------KKMVHVQDFTAFWDKASETPTLQGLSFTVR 436
Query: 590 PGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQ 649
PGE+ A+VGP G+GKS++ + + P+ G + +H ++A V Q+P
Sbjct: 437 PGELLAVVGPVGAGKSSLLSAVLGELAPSHGLV-------------SVHGRIAYVSQQPW 483
Query: 650 VFGRSLQENIAYGLTQKPTMEE--ITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQ 707
VF +L+ NI +G + E I A A+K + L G T + + G+ LSGGQ
Sbjct: 484 VFSGTLRSNILFGKKYEKERYEKVIKACALKKD----LQLLEDGDLTVIGDRGTTLSGGQ 539
Query: 708 RQAVALARALIRKPCVLILDDATSALDAN-----SQLQVEQLLYESPERYSRSVLLITQH 762
+ V LARA+ + + +LDD SA+DA +L + Q+L+E + +L+T
Sbjct: 540 KARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHE------KITILVTHQ 593
Query: 763 LSLVEQADHILFLEGGAIREGGTHQQLME 791
L ++ A IL L+ G + + GT+ + ++
Sbjct: 594 LQYLKAASQILILKDGKMVQKGTYTEFLK 622
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 121 bits (304), Expect = 2e-27
Identities = 120/529 (22%), Positives = 248/529 (46%), Gaps = 55/529 (10%)
Query: 296 IASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTL 355
+ S +E++G N +H +L ++ +R FF G I++R + DT+ +
Sbjct: 1052 VTSLTVEWMGLTAAKN----LHHNLLNKIILGPIR----FFDTTPLGLILNRFSADTNII 1103
Query: 356 SDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQ 415
+ L + L +G++ + + + +V L+ L + F + K++++
Sbjct: 1104 DQHIPPTLESLTRSTLLCLSAIGMISYAT-PVFLVALLPLGVAFYF---IQKYFRVASKD 1159
Query: 416 VRESLAKSSQVAI-----EALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAY-- 468
++E L S+Q+ + E + T+R+F +E +F++++ E+ N +AY
Sbjct: 1160 LQE-LDDSTQLPLLCHFSETAEGLTTIRAFRHET----RFKQRMLELTDTNN---IAYLF 1211
Query: 469 --AVNSWTTSISGMLLKVGILYIGGQLVT-------SGAVSSGNLVTFVLYQMQFTQAVE 519
A N W L+V Y+G +V SG+ +SG + +LY + T +
Sbjct: 1212 LSAANRW--------LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1263
Query: 520 VLLSIYPRVQKAVGSSEKIFEYLDRTPR-----CPPSGLLTPLHLEGLVQFQDVSFAYPN 574
++ ++ +G+ +K+ +L PS + EG ++ D+ Y N
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN 1323
Query: 575 RPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEH 634
VL+ + ++PG+ + G GSGKS+++ + G++++DG + +
Sbjct: 1324 NLKP-VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1382
Query: 635 RYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDT 694
L +++ + Q+P +F S++ N+ K T + + A + + + LP G D
Sbjct: 1383 HTLRSRLSIILQDPILFSGSIRFNLDPEC--KCTDDRLWEALEIAQLKNMVKSLPGGLDA 1440
Query: 695 EVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSR 754
V E G S GQRQ LARA +RK +LI+D+AT+++D ++ +++++ + R
Sbjct: 1441 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTA--FADR 1498
Query: 755 SVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLM-EKKGCYWAMVQA 802
+V+ I + + AD ++ ++ G I E T + L+ ++ G + + V+A
Sbjct: 1499 TVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVRA 1547
Score = 83.6 bits (205), Expect = 7e-16
Identities = 61/218 (27%), Positives = 108/218 (49%), Gaps = 9/218 (4%)
Query: 581 LQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQL----LLDGKPLPQYEHRY 636
L + + G++T +VG G GKS++ + Q G++ + + +P +
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 637 LHRQVAAVGQEPQVFGRSLQENIAYGLT-QKPTMEEITAAAVKSGAHSFISGLPQGYDTE 695
VA Q+P + +++ENI +G K + +T A I LP G TE
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTE 804
Query: 696 VDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDAN-SQLQVEQLLYESPERYSR 754
+ E G LSGGQRQ + +ARAL + ++ LDD SALD + S +++ + + + R
Sbjct: 805 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 864
Query: 755 SVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
+++L+T L + AD I+ ++ G++ GT + + K
Sbjct: 865 TLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTK 902
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 117 bits (294), Expect = 3e-26
Identities = 120/527 (22%), Positives = 242/527 (45%), Gaps = 55/527 (10%)
Query: 296 IASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTL 355
+ S +E++G N +H +L ++ +R FF G I++R + DT+ +
Sbjct: 1016 VTSLTVEWMGLTAAKN----LHHNLLNKIILGPIR----FFDTTPLGLILNRFSADTNII 1067
Query: 356 SDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQ 415
+ L + L +G++ + + + +V L+ L + F + K++++
Sbjct: 1068 DQHIPPTLESLTRSTLLCLSAIGMISYAT-PVFLVALLPLGVAFYF---IQKYFRVASKD 1123
Query: 416 VRESLAKSSQVAI-----EALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAY-- 468
++E L S+Q+ + E + T+R+F +E +F++++ E+ N +AY
Sbjct: 1124 LQE-LDDSTQLPLLCHFSETAEGLTTIRAFRHET----RFKQRMLELTDTNN---IAYLF 1175
Query: 469 --AVNSWTTSISGMLLKVGILYIGGQLVT-------SGAVSSGNLVTFVLYQMQFTQAVE 519
A N W L+V Y+G +V SG+ +SG + +LY + T +
Sbjct: 1176 LSAANRW--------LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1227
Query: 520 VLLSIYPRVQKAVGSSEKIFEYLDRTPR-----CPPSGLLTPLHLEGLVQFQDVSFAYPN 574
++ ++ +G+ +K+ +L PS + EG ++ D+ Y N
Sbjct: 1228 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN 1287
Query: 575 RPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEH 634
VL+ + ++PG+ + G GSGKS+++ + G++++DG + +
Sbjct: 1288 NLKP-VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1346
Query: 635 RYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDT 694
L +++ + Q+P +F S++ N+ K T + + A + + + LP G D
Sbjct: 1347 HTLRSRLSIILQDPILFSGSIRFNLDPEC--KCTDDRLWEALEIAQLKNMVKSLPGGLDA 1404
Query: 695 EVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSR 754
V E G S GQRQ LARA +RK +LI+D+AT+++D ++ +++++ + R
Sbjct: 1405 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTA--FADR 1462
Query: 755 SVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLM-EKKGCYWAMV 800
+V+ I +S + A +L G + E T L+ K G + +V
Sbjct: 1463 TVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
Score = 87.4 bits (215), Expect = 5e-17
Identities = 119/544 (21%), Positives = 232/544 (42%), Gaps = 35/544 (6%)
Query: 272 TDWILQDGSADTFTRNLTLMSILTIASAVLE--FVGDGIYNN--TMGHVHSHLQGEVFGA 327
T I + S+ F N ++++L + +L+ F+ Y T ++ L ++
Sbjct: 335 TTGISETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNK 394
Query: 328 VLRQETEFFQQNQT--GNIMSRVTEDTSTLSDSL--SENLSLFLWYLVRGLCLLGIMLWG 383
+LR T + G I + V +T+ L L NL ++ G+ LL +L
Sbjct: 395 ILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGS 454
Query: 384 SVSLTMVTLITL-PLLFLLPKKVGKWYQLLEVQVRESLAKSSQV--AIEALSAMPTVRSF 440
S + ++ L P+ + + K+ + + E L K++++ I+ L F
Sbjct: 455 SALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIF 514
Query: 441 ANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVS 500
E + ++L +KT +++ +N+ + + V Y G +
Sbjct: 515 CKSVEETRM--KELSSLKTFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAF 572
Query: 501 SGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYL------DRTPRCPPSGLL 554
+ + +L F + V ++ KA+ S +K+ E+L D + R S L
Sbjct: 573 ASLSLFHILVTPLFLLSTVVRFAV-----KAIISVQKLNEFLLSDEIGDDSWRTGESSLP 627
Query: 555 TPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNL 614
+ + F++ + + L + + G++T +VG G GKS++ +
Sbjct: 628 FESCKKHTGVVTNGYFSWGS--GLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGE 685
Query: 615 YQPTGGQL----LLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLT-QKPTM 669
Q G++ + + +P + VA Q+P + +++ENI +G K
Sbjct: 686 MQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRY 745
Query: 670 EEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDA 729
+ +T A I LP G TE+ E G LSGGQRQ + +ARAL + ++ LDD
Sbjct: 746 KAVTDAC---SLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDP 802
Query: 730 TSALDAN-SQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQ 788
SALD + S +++ + + + R+++L+T L + AD I+ ++ G++ GT +
Sbjct: 803 FSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKD 862
Query: 789 LMEK 792
+ K
Sbjct: 863 IQTK 866
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 117 bits (294), Expect = 3e-26
Identities = 120/527 (22%), Positives = 242/527 (45%), Gaps = 55/527 (10%)
Query: 296 IASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTL 355
+ S +E++G N +H +L ++ +R FF G I++R + DT+ +
Sbjct: 1052 VTSLTVEWMGLTAAKN----LHHNLLNKIILGPIR----FFDTTPLGLILNRFSADTNII 1103
Query: 356 SDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQ 415
+ L + L +G++ + + + +V L+ L + F + K++++
Sbjct: 1104 DQHIPPTLESLTRSTLLCLSAIGMISYAT-PVFLVALLPLGVAFYF---IQKYFRVASKD 1159
Query: 416 VRESLAKSSQVAI-----EALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAY-- 468
++E L S+Q+ + E + T+R+F +E +F++++ E+ N +AY
Sbjct: 1160 LQE-LDDSTQLPLLCHFSETAEGLTTIRAFRHET----RFKQRMLELTDTNN---IAYLF 1211
Query: 469 --AVNSWTTSISGMLLKVGILYIGGQLVT-------SGAVSSGNLVTFVLYQMQFTQAVE 519
A N W L+V Y+G +V SG+ +SG + +LY + T +
Sbjct: 1212 LSAANRW--------LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1263
Query: 520 VLLSIYPRVQKAVGSSEKIFEYLDRTPR-----CPPSGLLTPLHLEGLVQFQDVSFAYPN 574
++ ++ +G+ +K+ +L PS + EG ++ D+ Y N
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN 1323
Query: 575 RPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEH 634
VL+ + ++PG+ + G GSGKS+++ + G++++DG + +
Sbjct: 1324 NLKP-VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1382
Query: 635 RYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDT 694
L +++ + Q+P +F S++ N+ K T + + A + + + LP G D
Sbjct: 1383 HTLRSRLSIILQDPILFSGSIRFNLDPEC--KCTDDRLWEALEIAQLKNMVKSLPGGLDA 1440
Query: 695 EVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSR 754
V E G S GQRQ LARA +RK +LI+D+AT+++D ++ +++++ + R
Sbjct: 1441 VVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTA--FADR 1498
Query: 755 SVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLM-EKKGCYWAMV 800
+V+ I +S + A +L G + E T L+ K G + +V
Sbjct: 1499 TVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
Score = 83.6 bits (205), Expect = 7e-16
Identities = 61/218 (27%), Positives = 108/218 (49%), Gaps = 9/218 (4%)
Query: 581 LQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQL----LLDGKPLPQYEHRY 636
L + + G++T +VG G GKS++ + Q G++ + + +P +
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 637 LHRQVAAVGQEPQVFGRSLQENIAYGLT-QKPTMEEITAAAVKSGAHSFISGLPQGYDTE 695
VA Q+P + +++ENI +G K + +T A I LP G TE
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTE 804
Query: 696 VDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDAN-SQLQVEQLLYESPERYSR 754
+ E G LSGGQRQ + +ARAL + ++ LDD SALD + S +++ + + + R
Sbjct: 805 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 864
Query: 755 SVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEK 792
+++L+T L + AD I+ ++ G++ GT + + K
Sbjct: 865 TLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTK 902
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.406
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 31,089,995
Number of Sequences: 37866
Number of extensions: 1479716
Number of successful extensions: 5823
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 58
Number of HSP's that attempted gapping in prelim test: 5464
Number of HSP's gapped (non-prelim): 257
length of query: 808
length of database: 18,247,518
effective HSP length: 110
effective length of query: 698
effective length of database: 14,082,258
effective search space: 9829416084
effective search space used: 9829416084
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.