Search of human proteins with 9507163

Search of human proteins with 9507163

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|9507163 syntrophin, gamma 1 [Homo sapiens]
         (517 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9507163 syntrophin, gamma 1 [Homo sapiens]                        1053   0.0  
gi|9507165 syntrophin, gamma 2 [Homo sapiens]                         505   e-143
gi|5803177 basic beta 2 syntrophin [Homo sapiens]                     125   7e-29
gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]                   121   2e-27
gi|11321640 basic beta 1 syntrophin [Homo sapiens]                    115   1e-25
gi|9966877 golgi associated PDZ and coiled-coil motif containing...    70   6e-12
gi|62868213 golgi associated PDZ and coiled-coil motif containin...    70   6e-12
gi|74272282 membrane associated guanylate kinase, WW and PDZ dom...    64   4e-10
gi|66346708 membrane associated guanylate kinase, WW and PDZ dom...    62   1e-09
gi|74272284 membrane associated guanylate kinase, WW and PDZ dom...    62   1e-09
gi|27436957 membrane associated guanylate kinase, WW and PDZ dom...    61   3e-09
gi|148746189 multiple PDZ domain protein [Homo sapiens]                57   3e-08
gi|223890252 glutamate receptor interacting protein 1 [Homo sapi...    57   4e-08
gi|122937249 glutamate receptor interacting protein 2 [Homo sapi...    57   4e-08
gi|112382257 InaD-like [Homo sapiens]                                  55   2e-07
gi|45827729 scribble isoform b [Homo sapiens]                          55   2e-07
gi|45827731 scribble isoform a [Homo sapiens]                          55   2e-07
gi|4759306 lin-7 homolog A [Homo sapiens]                              55   2e-07
gi|11545920 lin-7 homolog B [Homo sapiens]                             54   4e-07
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi...    53   6e-07
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa...    53   6e-07
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi...    53   6e-07
gi|8922944 lin-7 homolog C [Homo sapiens]                              53   6e-07
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi...    53   8e-07
gi|13376349 PDZ domain containing 7 [Homo sapiens]                     53   8e-07
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]                      52   1e-06
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]                      52   1e-06
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]                       52   1e-06
gi|41281808 harmonin isoform b3 [Homo sapiens]                         52   1e-06
gi|71480164 harmonin isoform a [Homo sapiens]                          52   1e-06

>gi|9507163 syntrophin, gamma 1 [Homo sapiens]
          Length = 517

 Score = 1053 bits (2723), Expect = 0.0
 Identities = 517/517 (100%), Positives = 517/517 (100%)

Query: 1   MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 60
           MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI
Sbjct: 1   MDFRTACEETKTGICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTI 60

Query: 61  RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 120
           RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE
Sbjct: 61  RRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEE 120

Query: 121 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 180
           VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP
Sbjct: 121 VVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHP 180

Query: 181 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 240
           NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC
Sbjct: 181 NNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVC 240

Query: 241 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 300
           TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD
Sbjct: 241 TGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQD 300

Query: 301 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 360
           RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV
Sbjct: 301 RVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKILKDSDLLDRRKQCFTV 360

Query: 361 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 420
           QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF
Sbjct: 361 QSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLMGLTIDFSTGF 420

Query: 421 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH 480
           ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH
Sbjct: 421 ICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFSNLFAVLHCIH 480

Query: 481 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT 517
           SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT
Sbjct: 481 SFFAAKVACLDPLFLGNQATASTAASSATTSKAKYTT 517


>gi|9507165 syntrophin, gamma 2 [Homo sapiens]
          Length = 539

 Score =  505 bits (1300), Expect = e-143
 Identities = 260/511 (50%), Positives = 349/511 (68%), Gaps = 22/511 (4%)

Query: 10  TKTGICLLQDGNQE-PFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGF 68
           TKT I LL D   E  + +RL L K++L IQ+QDV+CV G       RTVT+RRQ VGG 
Sbjct: 25  TKTTIALLYDEESENAYDIRLKLTKEVLTIQKQDVVCVGGSHQGRNRRTVTLRRQPVGGL 84

Query: 69  GLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNA 128
           GLSIKGG+EHN+PVV+SKI ++Q A+ +G+LF+GDA+LQ+NGI+V    HEEVV +LRNA
Sbjct: 85  GLSIKGGSEHNVPVVISKIFEDQAADQTGMLFVGDAVLQVNGIHVENATHEEVVHLLRNA 144

Query: 129 GEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSC 188
           G+EVT+TV +L+ APAFLKLPL        SD SSG SSPL DSGLHLN + + T   S 
Sbjct: 145 GDEVTITVEYLREAPAFLKLPLGSPGPS--SDHSSGASSPLFDSGLHLNGNSSTTAPSSP 202

Query: 189 SSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIAVDGVCTGIIQCLS 248
           SS P +   R+EKRW D   +PL  +R S+Y  GT+  R NAF+V+A+DGV +GI++  +
Sbjct: 203 SS-PIAKDPRYEKRWLDTLSVPLSMARISRYKAGTEKLRWNAFEVLALDGVSSGILRFYT 261

Query: 249 AEDCVDWLQAIATNISNLTKHNIKKINRNFPVNQQIVYMGWCEAREQDPLQDRVYSPTFL 308
           A+D  DWL+A++ NI  LT  N+K  N+    + Q+V+MGW   + Q     + + P FL
Sbjct: 262 AQDGTDWLRAVSANIRELTLQNMKMANKCCSPSDQVVHMGWVNEKLQGADSSQTFRPKFL 321

Query: 309 ALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKI------------------LKDSDL 350
           AL+G   Y F  PPV+T+DW RAE+T+ + E++ K+                  L+D D 
Sbjct: 322 ALKGPSFYVFSTPPVSTFDWVRAERTYHLCEVLFKVHKFWLTEDCWLQANLYLGLQDFDF 381

Query: 351 LDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLEVERIQCKTYACVLESHLM 410
            D+R  CF++ +  G+   F+VEL S+LA WE++FQ ATF+EV+R   +TY C  +  ++
Sbjct: 382 EDQRPYCFSIVAGHGKSHVFNVELGSELAMWEKSFQRATFMEVQRTGSRTYMCSWQGEML 441

Query: 411 GLTIDFSTGFICFDAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTKQIEAKELEFS 470
             T+DF+ GF CF++ TK VLWR+KFSQLKGSSDDGK+++K LFQN DTKQIE KELEF 
Sbjct: 442 CFTVDFALGFTCFESKTKNVLWRFKFSQLKGSSDDGKTRVKLLFQNLDTKQIEMKELEFQ 501

Query: 471 NLFAVLHCIHSFFAAKVACLDPLFLGNQATA 501
           +L AVLHCIHSF AAKVA +DP F+ +Q+ A
Sbjct: 502 DLRAVLHCIHSFIAAKVASVDPGFMDSQSLA 532


>gi|5803177 basic beta 2 syntrophin [Homo sapiens]
          Length = 540

 Score =  125 bits (315), Expect = 7e-29
 Identities = 115/448 (25%), Positives = 195/448 (43%), Gaps = 44/448 (9%)

Query: 56  RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115
           R V + +Q  GG G+SIKGG E+ +P+++SKI     A+ S  L +GDAIL +NG ++R+
Sbjct: 114 RRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQ 173

Query: 116 CRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLP-LNEDCACAPSDQSSGTSSPLCDSGL 174
             H++ VQ L+ AG+EV L V F++    ++K P L  D     +   S + S   DSG 
Sbjct: 174 ATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSG- 232

Query: 175 HLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVI 234
               H N+T                     D ++IPL     ++ +   DL  +   ++ 
Sbjct: 233 -SPKHQNSTK--------------------DRKIIPLKMCFAARNLSMPDLENR-LIELH 270

Query: 235 AVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPV------NQQIVYMG 288
           + D   T I++C        W  AI TNI  L    + ++N           ++++ ++ 
Sbjct: 271 SPDSRNTLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIA 330

Query: 289 WCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKIL--- 345
           W   + +     + + P  +A+    L  +   P T   W  A    S   +  +++   
Sbjct: 331 WLAEQAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAW--ASPCHSYPLVATRLVHSG 388

Query: 346 ---KDSDLLDRRKQCFTVQSESGEDLY-FSVELESDLAQWERAFQTATFLEVERIQCKTY 401
              +   L           S  G +++ F VE   DL+ W R          E I+  + 
Sbjct: 389 SGCRSPSLGSDLTFATRTGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSL 448

Query: 402 ACVLESHLMGLTIDFSTGFICF--DAATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDT 459
            C+L    + LTI +  GF     +  + ++L+RY F +LK S+DDG   +   F  P+ 
Sbjct: 449 GCMLNGQEVRLTIHYENGFTISRENGGSSSILYRYPFERLKMSADDGIRNLYLDFGGPEG 508

Query: 460 KQIEAKELEFSNLFAVLHCIHSFFAAKV 487
              E      S    ++  +H+F +AKV
Sbjct: 509 ---ELTMDLHSCPKPIVFVLHTFLSAKV 533


>gi|4507137 acidic alpha 1 syntrophin [Homo sapiens]
          Length = 505

 Score =  121 bits (303), Expect = 2e-27
 Identities = 122/450 (27%), Positives = 190/450 (42%), Gaps = 49/450 (10%)

Query: 56  RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115
           R VT+R+   GG G+SIKGG E+ +P+++SKI K   A+ +  LF+GDAIL +NG ++  
Sbjct: 86  RRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSS 145

Query: 116 CRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLH 175
             H+E VQVL+  G+EV L V ++K    + K              S+G +S   DS   
Sbjct: 146 ATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFK-------------NSTGGTSVGWDS--- 189

Query: 176 LNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQNAFQVIA 235
                           P+SPG    + + + + + L  +  S+     D       ++ +
Sbjct: 190 -------PPASPLQRQPSSPG-PTPRNFSEAKHMSLKMAYVSKRCTPND-PEPRYLEICS 240

Query: 236 VDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINRNFPV-----NQQIVYMGWC 290
            DG  T  ++         W  AI   ++ LT     ++           +Q I  +GW 
Sbjct: 241 ADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWL 300

Query: 291 EAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCKIL----- 345
                + L     +PT   L    L  +L+ P T    +R  +T  +  I  +++     
Sbjct: 301 ----TEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPL--IATRLVHSGPS 354

Query: 346 KDSDLLDRRKQ-CFTVQSESGEDLY-FSVELESDLAQWERAFQTATFLEVERIQCKTYAC 403
           K S   D          +  G D + FSVE   +LA W R          E +Q  + AC
Sbjct: 355 KGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTAC 414

Query: 404 VLESHLMGLTIDFSTGFICFDA---ATKAVLWRYKFSQLKGSSDDGKSKIKFLFQNPDTK 460
                   L++    GF  + A   A +AVL R  F +L+ SSDDG S    LF +    
Sbjct: 415 TWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGAS---LLFLDFGGA 471

Query: 461 QIEAKELEFSNLFAVLHCIHSFFAAKVACL 490
           + E +    S    ++  IHSF +AKV  L
Sbjct: 472 EGEIQLDLHSCPKTIVFIIHSFLSAKVTRL 501


>gi|11321640 basic beta 1 syntrophin [Homo sapiens]
          Length = 538

 Score =  115 bits (287), Expect = 1e-25
 Identities = 113/459 (24%), Positives = 195/459 (42%), Gaps = 45/459 (9%)

Query: 49  EPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQI 108
           E   + +R V + +Q +GG G+SIKGG E+ +P+++SKI K   A+ +  L++GDAIL +
Sbjct: 104 ESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSV 163

Query: 109 NGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSP 168
           NG ++R   H+E VQ L+ AG+EV L V +++ A  ++K                   SP
Sbjct: 164 NGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVK-----------------KGSP 206

Query: 169 LCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPLLHSRFSQYVPGTDLSRQ 228
           + + G       +     S S  P+S    + +   D + IPL     ++ +   D    
Sbjct: 207 VSEIGWETPPPESPRLGGSTSDPPSSQSFSFHR---DRKSIPLKMCYVTRSMALAD-PEN 262

Query: 229 NAFQVIAVDGVCTGIIQCLSAEDCVDWLQAIATNISNLTKHNIKKINR-----NFPVNQQ 283
              ++ + D   T I++   +     W  AI +N+++L    I ++           +++
Sbjct: 263 RQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAGSRE 322

Query: 284 IVYMGWCEAREQDPLQDRVYSPTFLALRGSCLYKFLAPPVTTWDWTRAEKTFSVYEIMCK 343
           I ++GW  A +      + + P  + L    L  + + P     W     T   Y ++  
Sbjct: 323 IRHLGWL-AEKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHT---YPLLAT 378

Query: 344 ILKDSDL--------LDRRKQCFTVQSESGEDLYFSVELESDLAQWERAFQTATFLEVER 395
            L  S          +D      T   +  E   F  E   DL+ W R+         E 
Sbjct: 379 RLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAEL 438

Query: 396 IQCKTYACVLESHLMGLTIDFSTGFICF----DAATKAVLWRYKFSQLKGSSDDGKSKIK 451
           I   + AC  ++    LTI +  GF       + A    + +  + +LK SSDDG   I+
Sbjct: 439 IAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDG---IR 495

Query: 452 FLFQNPDTKQIEAKELEFSNLFAVLHCIHSFFAAKVACL 490
            L+ +   K  E +    S    ++  IHSF +AK+  L
Sbjct: 496 MLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRL 534


>gi|9966877 golgi associated PDZ and coiled-coil motif containing
           isoform a [Homo sapiens]
          Length = 462

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 32/84 (38%), Positives = 52/84 (61%)

Query: 56  RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115
           R V + ++   G G+SI GG EH +P+++S+I   Q A+  G L +GDAIL +NG+N+R 
Sbjct: 287 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 346

Query: 116 CRHEEVVQVLRNAGEEVTLTVSFL 139
            +H+E V +L     E+   V ++
Sbjct: 347 TKHKEAVTILSQQRGEIEFEVVYV 370


>gi|62868213 golgi associated PDZ and coiled-coil motif containing
           isoform b [Homo sapiens]
          Length = 454

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 32/84 (38%), Positives = 52/84 (61%)

Query: 56  RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115
           R V + ++   G G+SI GG EH +P+++S+I   Q A+  G L +GDAIL +NG+N+R 
Sbjct: 279 RKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRD 338

Query: 116 CRHEEVVQVLRNAGEEVTLTVSFL 139
            +H+E V +L     E+   V ++
Sbjct: 339 TKHKEAVTILSQQRGEIEFEVVYV 362


>gi|74272282 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform a [Homo sapiens]
          Length = 1287

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 32/89 (35%), Positives = 53/89 (59%), Gaps = 7/89 (7%)

Query: 67   GFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
            GFG S++GG E+N+ + V +++++  AE  G + IGD IL+ING   +  +H   +++++
Sbjct: 1160 GFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1219

Query: 127  NAGEEVTLTVSFLKR----APAFLKLPLN 151
            N G  V L   FLKR     P +  +P N
Sbjct: 1220 NGGRRVRL---FLKRGDGSVPEYAMIPPN 1245



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 38/145 (26%), Positives = 66/145 (45%), Gaps = 2/145 (1%)

Query: 50  PFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQIN 109
           P Y  +     R++T  GFG  I GG E   P+ +  I     A+  G L  GD ++ ++
Sbjct: 835 PDYQEQDIFLWRKET--GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVD 892

Query: 110 GINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPL 169
           G  V    H+ VVQ+++ A ++  + ++  ++    +    NE  + A S  SS   + L
Sbjct: 893 GTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASL 952

Query: 170 CDSGLHLNYHPNNTDTLSCSSWPTS 194
            +         N+ +T+S  S  TS
Sbjct: 953 TEEKRTPQGSQNSLNTVSSGSGSTS 977



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 12/91 (13%)

Query: 58   VTIRRQTVGGFGLSIK------------GGAEHNIPVVVSKISKEQRAELSGLLFIGDAI 105
            V IRR    GFG  I             G A   +P  + +I +   A+  G L +GD I
Sbjct: 999  VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1058

Query: 106  LQINGINVRKCRHEEVVQVLRNAGEEVTLTV 136
            L +NG ++    H ++V +++ AG  VTL +
Sbjct: 1059 LAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1089



 Score = 37.0 bits (84), Expect = 0.043
 Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 7/89 (7%)

Query: 46  VSGEPFYS-------GERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGL 98
           + G+PF++       G+   T  R++  GFG ++ GG E +  + +  +  +  A L G 
Sbjct: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGK 512

Query: 99  LFIGDAILQINGINVRKCRHEEVVQVLRN 127
           +  GD I+ +N   V    H +VV++ ++
Sbjct: 513 METGDVIVSVNDTCVLGHTHAQVVKIFQS 541



 Score = 36.2 bits (82), Expect = 0.074
 Identities = 23/80 (28%), Positives = 40/80 (50%), Gaps = 5/80 (6%)

Query: 59  TIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSG-----LLFIGDAILQINGINV 113
           T++R   G  G+++ GGAEH     V  ++  + A L G      L  G+ +L++ G+ V
Sbjct: 19  TVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRV 78

Query: 114 RKCRHEEVVQVLRNAGEEVT 133
                 +V+ V+ +  E VT
Sbjct: 79  SGLPRYDVLGVIDSCKEAVT 98



 Score = 29.3 bits (64), Expect = 9.0
 Identities = 16/37 (43%), Positives = 22/37 (59%), Gaps = 2/37 (5%)

Query: 102 GDAILQINGINVRKCRHEEVVQVLRNA--GEEVTLTV 136
           GD I+++N  NV+   H +VV +L     G EVTL V
Sbjct: 683 GDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLV 719


>gi|66346708 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform b [Homo sapiens]
          Length = 1256

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 29/75 (38%), Positives = 48/75 (64%), Gaps = 3/75 (4%)

Query: 67   GFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
            GFG S++GG E+N+ + V +++++  AE  G + IGD IL+ING   +  +H   +++++
Sbjct: 1161 GFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1220

Query: 127  NAGEEVTLTVSFLKR 141
            N G  V L   FLKR
Sbjct: 1221 NGGRRVRL---FLKR 1232



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 38/145 (26%), Positives = 66/145 (45%), Gaps = 2/145 (1%)

Query: 50  PFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQIN 109
           P Y  +     R++T  GFG  I GG E   P+ +  I     A+  G L  GD ++ ++
Sbjct: 835 PDYQEQDIFLWRKET--GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVD 892

Query: 110 GINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPL 169
           G  V    H+ VVQ+++ A ++  + ++  ++    +    NE  + A S  SS   + L
Sbjct: 893 GTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASL 952

Query: 170 CDSGLHLNYHPNNTDTLSCSSWPTS 194
            +         N+ +T+S  S  TS
Sbjct: 953 TEEKRTPQGSQNSLNTVSSGSGSTS 977



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 21/68 (30%), Positives = 37/68 (54%)

Query: 69   GLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNA 128
            G +  G A   +P  + +I +   A+  G L +GD IL +NG ++    H ++V +++ A
Sbjct: 1023 GTTFAGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVNGCSITNKSHSDIVNLIKEA 1082

Query: 129  GEEVTLTV 136
            G  VTL +
Sbjct: 1083 GNTVTLRI 1090



 Score = 37.0 bits (84), Expect = 0.043
 Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 7/89 (7%)

Query: 46  VSGEPFYS-------GERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGL 98
           + G+PF++       G+   T  R++  GFG ++ GG E +  + +  +  +  A L G 
Sbjct: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGK 512

Query: 99  LFIGDAILQINGINVRKCRHEEVVQVLRN 127
           +  GD I+ +N   V    H +VV++ ++
Sbjct: 513 METGDVIVSVNDTCVLGHTHAQVVKIFQS 541



 Score = 36.2 bits (82), Expect = 0.074
 Identities = 23/80 (28%), Positives = 40/80 (50%), Gaps = 5/80 (6%)

Query: 59  TIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSG-----LLFIGDAILQINGINV 113
           T++R   G  G+++ GGAEH     V  ++  + A L G      L  G+ +L++ G+ V
Sbjct: 19  TVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRV 78

Query: 114 RKCRHEEVVQVLRNAGEEVT 133
                 +V+ V+ +  E VT
Sbjct: 79  SGLPRYDVLGVIDSCKEAVT 98



 Score = 29.3 bits (64), Expect = 9.0
 Identities = 16/37 (43%), Positives = 22/37 (59%), Gaps = 2/37 (5%)

Query: 102 GDAILQINGINVRKCRHEEVVQVLRNA--GEEVTLTV 136
           GD I+++N  NV+   H +VV +L     G EVTL V
Sbjct: 683 GDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLV 719


>gi|74272284 membrane associated guanylate kinase, WW and PDZ domain
            containing 1 isoform c [Homo sapiens]
          Length = 1462

 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 29/75 (38%), Positives = 48/75 (64%), Gaps = 3/75 (4%)

Query: 67   GFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
            GFG S++GG E+N+ + V +++++  AE  G + IGD IL+ING   +  +H   +++++
Sbjct: 1132 GFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKHSRAIELIK 1191

Query: 127  NAGEEVTLTVSFLKR 141
            N G  V L   FLKR
Sbjct: 1192 NGGRRVRL---FLKR 1203



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 38/145 (26%), Positives = 66/145 (45%), Gaps = 2/145 (1%)

Query: 50  PFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQIN 109
           P Y  +     R++T  GFG  I GG E   P+ +  I     A+  G L  GD ++ ++
Sbjct: 807 PDYQEQDIFLWRKET--GFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVD 864

Query: 110 GINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPL 169
           G  V    H+ VVQ+++ A ++  + ++  ++    +    NE  + A S  SS   + L
Sbjct: 865 GTPVIGKSHQLVVQLMQQAAKQGHVNLTVRRKVVFAVPKTENEVPSPASSHHSSNQPASL 924

Query: 170 CDSGLHLNYHPNNTDTLSCSSWPTS 194
            +         N+ +T+S  S  TS
Sbjct: 925 TEEKRTPQGSQNSLNTVSSGSGSTS 949



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 28/91 (30%), Positives = 43/91 (47%), Gaps = 12/91 (13%)

Query: 58   VTIRRQTVGGFGLSIK------------GGAEHNIPVVVSKISKEQRAELSGLLFIGDAI 105
            V IRR    GFG  I             G A   +P  + +I +   A+  G L +GD I
Sbjct: 971  VEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVGDRI 1030

Query: 106  LQINGINVRKCRHEEVVQVLRNAGEEVTLTV 136
            L +NG ++    H ++V +++ AG  VTL +
Sbjct: 1031 LAVNGCSITNKSHSDIVNLIKEAGNTVTLRI 1061



 Score = 37.0 bits (84), Expect = 0.043
 Identities = 23/89 (25%), Positives = 45/89 (50%), Gaps = 7/89 (7%)

Query: 46  VSGEPFYS-------GERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGL 98
           + G+PF++       G+   T  R++  GFG ++ GG E +  + +  +  +  A L G 
Sbjct: 453 LQGKPFFTRNPSELKGKFIHTKLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGK 512

Query: 99  LFIGDAILQINGINVRKCRHEEVVQVLRN 127
           +  GD I+ +N   V    H +VV++ ++
Sbjct: 513 METGDVIVSVNDTCVLGHTHAQVVKIFQS 541



 Score = 36.2 bits (82), Expect = 0.074
 Identities = 23/80 (28%), Positives = 40/80 (50%), Gaps = 5/80 (6%)

Query: 59  TIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSG-----LLFIGDAILQINGINV 113
           T++R   G  G+++ GGAEH     V  ++  + A L G      L  G+ +L++ G+ V
Sbjct: 19  TVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRV 78

Query: 114 RKCRHEEVVQVLRNAGEEVT 133
                 +V+ V+ +  E VT
Sbjct: 79  SGLPRYDVLGVIDSCKEAVT 98



 Score = 29.3 bits (64), Expect = 9.0
 Identities = 16/37 (43%), Positives = 22/37 (59%), Gaps = 2/37 (5%)

Query: 102 GDAILQINGINVRKCRHEEVVQVLRNA--GEEVTLTV 136
           GD I+++N  NV+   H +VV +L     G EVTL V
Sbjct: 683 GDLIVEVNKKNVQALTHNQVVDMLVECPKGSEVTLLV 719


>gi|27436957 membrane associated guanylate kinase, WW and PDZ domain
            containing 2 [Homo sapiens]
          Length = 1455

 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 45/147 (30%), Positives = 73/147 (49%), Gaps = 13/147 (8%)

Query: 67   GFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
            GFG SI+GG E+ + + V +++++  A  +G + +GD I++ING + R   H   +++++
Sbjct: 1156 GFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTHARAIELIK 1215

Query: 127  NAGEEVTLTVSFLKRAPAFL-----KLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPN 181
            + G  V L    LKR    +       P +   A AP     G S    D GL   + P+
Sbjct: 1216 SGGRRVRL---LLKRGTGQVPEYDEPAPWSSPAAAAPGLPEVGVS---LDDGL-APFSPS 1268

Query: 182  NTDTLSCSSWPTSPGLRWE-KRWCDLR 207
            +    S  S   SPG  W+ KR  D+R
Sbjct: 1269 HPAPPSDPSHQISPGPTWDIKREHDVR 1295



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 44/177 (24%), Positives = 76/177 (42%), Gaps = 24/177 (13%)

Query: 58   VTIRRQTVGGFGLSI-------KGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQING 110
            V I R+   GFG  I       + G+   +P  + +I     A+    L +GD IL +NG
Sbjct: 921  VVIHRKENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNG 980

Query: 111  INVRKCRHEEVVQVLRNAGEEVTLTV-------------SFLKRAPAFLKLPLNEDCACA 157
             ++    H ++V+++++AG  VTL +             S  K++P   + PL +    A
Sbjct: 981  QSIINMPHADIVKLIKDAGLSVTLRIIPQEELNSPTSAPSSEKQSPMAQQSPLAQQSPLA 1040

Query: 158  ---PSDQSSGTSSPLCDSGLHLNYHPNNTDTLSCSSWPTSPGLRWEKRWCDLRLIPL 211
               P+  +S  + P     L L  H N+  +   +     P +R +  + D R  PL
Sbjct: 1041 QPSPATPNSPIAQPAPPQPLQLQGHENSYRSEVKARQDVKPDIR-QPPFTDYRQPPL 1096



 Score = 43.1 bits (100), Expect = 6e-04
 Identities = 40/133 (30%), Positives = 60/133 (45%), Gaps = 8/133 (6%)

Query: 47  SGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAIL 106
           S  P Y  E  V +RR    GFG  I GG E   P+++  +     A+  G L  GD ++
Sbjct: 769 SSGPDYK-ELDVHLRRME-SGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELV 826

Query: 107 QINGINVRKCRHEEVVQVLRNAGE--EVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSG 164
            ++GI V    H  V+ ++ +A    +V LTV   +R       P  E+   +P   S+ 
Sbjct: 827 YVDGIPVAGKTHRYVIDLMHHAARNGQVNLTV---RRKVLCGGEPCPEN-GRSPGSVSTH 882

Query: 165 TSSPLCDSGLHLN 177
            SSP  D   + N
Sbjct: 883 HSSPRSDYATYTN 895



 Score = 34.3 bits (77), Expect = 0.28
 Identities = 23/82 (28%), Positives = 43/82 (52%), Gaps = 3/82 (3%)

Query: 57  TVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKC 116
           + T+++  +G FG +I GG E +  + V  +  +  A   G +  GD I+ IN + V   
Sbjct: 426 STTLKKSNMG-FGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGH 484

Query: 117 RHEEVVQVLRNA--GEEVTLTV 136
            H +VV++ ++   G+ V L +
Sbjct: 485 THADVVKLFQSVPIGQSVNLVL 506



 Score = 30.4 bits (67), Expect = 4.1
 Identities = 15/37 (40%), Positives = 23/37 (62%), Gaps = 2/37 (5%)

Query: 102 GDAILQINGINVRKCRHEEVVQVLRNA--GEEVTLTV 136
           GD I++IN  NV+   H EVV +L++   G E +L +
Sbjct: 643 GDLIVEINQQNVQNLSHTEVVDILKDCPIGSETSLII 679


>gi|148746189 multiple PDZ domain protein [Homo sapiens]
          Length = 2041

 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 40/121 (33%), Positives = 62/121 (51%), Gaps = 6/121 (4%)

Query: 18   QDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSG-ERTVTIRRQTVGGFGLSIKGGA 76
            Q G+ EP  +R         I   D       P   G E T+ I +   G  GLSI GG+
Sbjct: 1592 QSGSPEPESIRNTSRSSTPAIFASDPATC---PIIPGCETTIEISKGRTG-LGLSIVGGS 1647

Query: 77   EHNI-PVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLT 135
            +  +  +++ ++ +E  A   G L+ GD IL++NGI++RK  H+E + VLR   + V LT
Sbjct: 1648 DTLLGAIIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLT 1707

Query: 136  V 136
            +
Sbjct: 1708 L 1708



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 35/105 (33%), Positives = 52/105 (49%), Gaps = 10/105 (9%)

Query: 22   QEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIP 81
            Q P +VRL L +D    +E++V             T+ ++++   G GLSI G   ++  
Sbjct: 1699 QTPQRVRLTLYRDEAPYKEEEVC---------DTLTIELQKKPGKGLGLSIVG-KRNDTG 1748

Query: 82   VVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
            V VS I K   A+  G L  GD IL +NG +VR    E V  +L+
Sbjct: 1749 VFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVAALLK 1793



 Score = 44.7 bits (104), Expect = 2e-04
 Identities = 28/103 (27%), Positives = 48/103 (46%), Gaps = 9/103 (8%)

Query: 56   RTVTIRRQTVGGFGLSIKGG---------AEHNIPVVVSKISKEQRAELSGLLFIGDAIL 106
            R V + R+     G+SI GG          E    + +  + ++  A  +G L  GD I+
Sbjct: 1150 RRVELWREPSKSLGISIVGGRGMGSRLSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIV 1209

Query: 107  QINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLP 149
            +++G+++R   HE+ V+ +R AG  V   V  +   P    LP
Sbjct: 1210 EVDGMDLRDASHEQAVEAIRKAGNPVVFMVQSIINRPRKSPLP 1252



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 26/78 (33%), Positives = 45/78 (57%), Gaps = 4/78 (5%)

Query: 63  QTVGGFGLSIKG--GAEHNIP--VVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRH 118
           + V G G++I G  G +   P  + V  I+K    E  G + IGD I+ ++G N++   +
Sbjct: 382 KNVQGLGITIAGYIGDKKLEPSGIFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTN 441

Query: 119 EEVVQVLRNAGEEVTLTV 136
           ++ V+VLR+ G+ V LT+
Sbjct: 442 QQAVEVLRHTGQTVLLTL 459



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 4/84 (4%)

Query: 56   RTVTIRRQTVGGFGLSIKGG---AEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGIN 112
            +++T+ R    G G SI GG      ++P+ V  +  +  A   G L  GD I+ +NG +
Sbjct: 1957 KSITLERGP-DGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASEDGRLKRGDQIIAVNGQS 2015

Query: 113  VRKCRHEEVVQVLRNAGEEVTLTV 136
            +    HEE V +L+     VTL V
Sbjct: 2016 LEGVTHEEAVAILKRTKGTVTLMV 2039



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 18/105 (17%)

Query: 67  GFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
           G G+S++    H+    +  +  E     SG LF GD +L++NGI +    H++VV +L+
Sbjct: 564 GLGISLEATVGHHF---IRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILK 620

Query: 127 NAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCD 171
               EVT+ V   +  P              P+ QS   S  LCD
Sbjct: 621 ELPIEVTM-VCCRRTVP--------------PTTQSELDSLDLCD 650



 Score = 39.7 bits (91), Expect = 0.007
 Identities = 23/86 (26%), Positives = 42/86 (48%), Gaps = 3/86 (3%)

Query: 54   GERTVTIRRQTVGGFGLSIKGGAEH---NIPVVVSKISKEQRAELSGLLFIGDAILQING 110
            G RTV +++      G+SI GG      ++P+ ++ +     A  +  L +GD I+ I G
Sbjct: 1830 GLRTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICG 1889

Query: 111  INVRKCRHEEVVQVLRNAGEEVTLTV 136
             +     H + V +L+NA   + + V
Sbjct: 1890 TSTEGMTHTQAVNLLKNASGSIEMQV 1915



 Score = 35.8 bits (81), Expect = 0.097
 Identities = 25/71 (35%), Positives = 33/71 (46%), Gaps = 2/71 (2%)

Query: 67  GFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
           G G  I GG      V+V  I     A+  G L  GD IL+I   ++     E+V QVLR
Sbjct: 266 GLGFGIIGGKATG--VIVKTILPGGVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLR 323

Query: 127 NAGEEVTLTVS 137
             G  V L ++
Sbjct: 324 QCGNRVKLMIA 334


>gi|223890252 glutamate receptor interacting protein 1 [Homo
           sapiens]
          Length = 1076

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 29/87 (33%), Positives = 48/87 (55%)

Query: 52  YSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGI 111
           + G   V + ++     GL++ GG + +    VS + +   A  S  L +GD I  +NGI
Sbjct: 48  FKGSTVVELMKKEGTTLGLTVSGGIDKDGKPRVSNLRQGGIAARSDQLDVGDYIKAVNGI 107

Query: 112 NVRKCRHEEVVQVLRNAGEEVTLTVSF 138
           N+ K RH+E++ +L+N GE V L V +
Sbjct: 108 NLAKFRHDEIISLLKNVGERVVLEVEY 134



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 41/128 (32%), Positives = 60/128 (46%), Gaps = 13/128 (10%)

Query: 47  SGEPFYSGERTVTIRRQTVGG-FGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAI 105
           S E   SG    T+  +  GG  G++I G  E   P+++S ++K   AE +G + IGD I
Sbjct: 609 SDEQESSGAIIYTVELKRYGGPLGITISGTEEPFDPIIISSLTKGGLAERTGAIHIGDRI 668

Query: 106 LQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGT 165
           L IN  +++     E + +L+ AGE VT            LK+    D   A S +    
Sbjct: 669 LAINSSSLKGKPLSEAIHLLQMAGETVT------------LKIKKQTDAQSASSPKKFPI 716

Query: 166 SSPLCDSG 173
           SS L D G
Sbjct: 717 SSHLSDLG 724



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 35/123 (28%), Positives = 59/123 (47%), Gaps = 14/123 (11%)

Query: 22  QEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGA----E 77
           ++ FK  L LA           + ++G+  ++    V +    V GFG+ ++G       
Sbjct: 393 KKDFKSSLSLASS--------TVGLAGQVVHTETTEVVLTADPVTGFGIQLQGSVFATET 444

Query: 78  HNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAG--EEVTLT 135
            + P ++S I  +  AE  G+L IGD ++ INGI       EE  Q+LR++    +VTL 
Sbjct: 445 LSSPPLISYIEADSPAERCGVLQIGDRVMAINGIPTEDSTFEEASQLLRDSSITSKVTLE 504

Query: 136 VSF 138
           + F
Sbjct: 505 IEF 507



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 49/184 (26%), Positives = 74/184 (40%), Gaps = 10/184 (5%)

Query: 13  GICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSI 72
           GI LL   + E   +     ++  ++ E DV  +      SG   V + +      G+++
Sbjct: 208 GIRLLGTTHAEAMSILKQCGQEAALLIEYDVSVMDSVATASGPLLVEVAKTPGASLGVAL 267

Query: 73  KGGAEHNIPVVV-SKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEE 131
                 N  V+V  KI     A+  G L +GD IL I+G ++  C   E  Q L N  ++
Sbjct: 268 TTSMCCNKQVIVIDKIKSASIADRCGALHVGDHILSIDGTSMEYCTLAEATQFLANTTDQ 327

Query: 132 VTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPNNTDTLSCSSW 191
           V L +    +    LK P  +  A   S  S  + S    S L       N  TL  S +
Sbjct: 328 VKLEILPHHQTRLALKGP--DHAALVSSSFSPTSMSAYSLSSL-------NMGTLPRSLY 378

Query: 192 PTSP 195
            TSP
Sbjct: 379 STSP 382



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 33/131 (25%), Positives = 63/131 (48%), Gaps = 5/131 (3%)

Query: 13  GICLLQDGNQEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGG-FGLS 71
           GI L +  + E   +  ++ + +++  E ++  VS +      RTV +     G  FG  
Sbjct: 106 GINLAKFRHDEIISLLKNVGERVVLEVEYELPPVSVQGSSVIFRTVEVTLHKEGNTFGFV 165

Query: 72  IKGGAEHNI----PVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRN 127
           I+GGA  +     PVV++ +     A+  G +  GD +L ++GI +    H E + +L+ 
Sbjct: 166 IRGGAHDDRNKSRPVVITCVRPGGPADREGTIKPGDRLLSVDGIRLLGTTHAEAMSILKQ 225

Query: 128 AGEEVTLTVSF 138
            G+E  L + +
Sbjct: 226 CGQEAALLIEY 236



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 22/70 (31%), Positives = 36/70 (51%)

Query: 67  GFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
           G  +S     +   P+V+S I K   A  +G L +GD +L I+ I +  C  E+ VQ+L+
Sbjct: 533 GITISSPSSRKPGDPLVISDIKKGSVAHRTGTLELGDKLLAIDNIRLDNCSMEDAVQILQ 592

Query: 127 NAGEEVTLTV 136
              + V L +
Sbjct: 593 QCEDLVKLKI 602


>gi|122937249 glutamate receptor interacting protein 2 [Homo
           sapiens]
          Length = 1141

 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 32/93 (34%), Positives = 50/93 (53%)

Query: 52  YSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGI 111
           + G   V + ++     GL+I GG + +    VS +     A  S LL IGD I  +NGI
Sbjct: 140 FRGITVVELIKKEGSTLGLTISGGTDKDGKPRVSNLRPGGLAARSDLLNIGDYIRSVNGI 199

Query: 112 NVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPA 144
           ++ + RH+E++ +L+N GE V L V +    PA
Sbjct: 200 HLTRLRHDEIITLLKNVGERVVLEVEYELPPPA 232



 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 29/85 (34%), Positives = 50/85 (58%), Gaps = 1/85 (1%)

Query: 53  SGERTVTIRRQTVGG-FGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGI 111
           +G  + T+  +  GG  G++I G  E   P+V+S ++K   AE +G + +GD IL IN +
Sbjct: 748 TGAVSYTVELKRYGGPLGITISGTEEPFDPIVISGLTKRGLAERTGAIHVGDRILAINNV 807

Query: 112 NVRKCRHEEVVQVLRNAGEEVTLTV 136
           +++     E + +L+ AGE VTL +
Sbjct: 808 SLKGRPLSEAIHLLQVAGETVTLKI 832



 Score = 46.6 bits (109), Expect = 5e-05
 Identities = 33/97 (34%), Positives = 48/97 (49%), Gaps = 6/97 (6%)

Query: 48  GEPFYSGERTVTIRRQTVGGFGLSIKGGA----EHNIPVVVSKISKEQRAELSGLLFIGD 103
           G+  ++    V +    + GFGL ++GG       + P +V  I  +  AE  GLL +GD
Sbjct: 545 GQIVHTETTEVVLCGDPLSGFGLQLQGGIFATETLSSPPLVCFIEPDSPAERCGLLQVGD 604

Query: 104 AILQINGINVRKCRHEEVVQVLRNA--GEEVTLTVSF 138
            +L INGI       EE  Q+LR+A    +V L V F
Sbjct: 605 RVLSINGIATEDGTMEEANQLLRDAALAHKVVLEVEF 641



 Score = 40.0 bits (92), Expect = 0.005
 Identities = 25/85 (29%), Positives = 43/85 (50%), Gaps = 1/85 (1%)

Query: 53  SGERTVTIRRQTVGGFGLSIKGGA-EHNIPVVVSKISKEQRAELSGLLFIGDAILQINGI 111
           SG   V + ++     G++I   + +   P+++S I K   A  +G L  GD +L I+ I
Sbjct: 651 SGTFHVKLPKKRSVELGITISSASRKRGEPLIISDIKKGSVAHRTGTLEPGDKLLAIDNI 710

Query: 112 NVRKCRHEEVVQVLRNAGEEVTLTV 136
            +  C  E+ VQ+LR   + V L +
Sbjct: 711 RLDNCPMEDAVQILRQCEDLVKLKI 735



 Score = 37.0 bits (84), Expect = 0.043
 Identities = 20/75 (26%), Positives = 35/75 (46%), Gaps = 4/75 (5%)

Query: 68  FGLSIKGGAEHN----IPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQ 123
           FG  ++GGA  +     P+V++ +     A+  G L +GD +L ++GI +    H   + 
Sbjct: 255 FGFVLRGGAHEDGHKSRPLVLTYVRPGGPADREGSLKVGDRLLSVDGIPLHGASHATALA 314

Query: 124 VLRNAGEEVTLTVSF 138
            LR    E    V +
Sbjct: 315 TLRQCSHEALFQVEY 329


>gi|112382257 InaD-like [Homo sapiens]
          Length = 1801

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/88 (32%), Positives = 48/88 (54%), Gaps = 1/88 (1%)

Query: 50   PFYSGERTVTIRRQTVGGFGLSIKGGAEHNI-PVVVSKISKEQRAELSGLLFIGDAILQI 108
            P   G+  +    +   G GLSI GG +  +  +V+ ++ +E  A   G L+ GD IL++
Sbjct: 1429 PIVPGQEMIIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEV 1488

Query: 109  NGINVRKCRHEEVVQVLRNAGEEVTLTV 136
            NG+++R   HEE +  LR   ++V L V
Sbjct: 1489 NGVDLRNSSHEEAITALRQTPQKVRLVV 1516



 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 39/105 (37%), Positives = 46/105 (43%), Gaps = 10/105 (9%)

Query: 67  GFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
           G G  I GG      VVV  I     A+  G L  GD IL+I G NV+    E+V QVLR
Sbjct: 257 GLGFGIVGGKTSG--VVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQGMTSEQVAQVLR 314

Query: 127 NAGEEVTLTV--------SFLKRAPAFLKLPLNEDCACAPSDQSS 163
           N G  V + V        S    APA L + L    +  P   SS
Sbjct: 315 NCGNSVRMLVARDPAGDISVTPPAPAALPVALPTVASKGPGSDSS 359



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 27/97 (27%), Positives = 46/97 (47%), Gaps = 9/97 (9%)

Query: 56   RTVTIRRQTVGGFGLSIKGG---------AEHNIPVVVSKISKEQRAELSGLLFIGDAIL 106
            R V I R+     G+SI GG          E    + + ++ ++  A  +  L  GD IL
Sbjct: 1067 RIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKIL 1126

Query: 107  QINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAP 143
            +++G++++   H E V+ ++NAG  V   V  L   P
Sbjct: 1127 EVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTP 1163



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 30/84 (35%), Positives = 43/84 (51%), Gaps = 3/84 (3%)

Query: 56   RTVTIRRQTVGGFGLSIKGGAEH---NIPVVVSKISKEQRAELSGLLFIGDAILQINGIN 112
            RTV I R+     G+SI GG      +IPV ++ I     A  +  L +GD I+ ING  
Sbjct: 1675 RTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQP 1734

Query: 113  VRKCRHEEVVQVLRNAGEEVTLTV 136
            +    H +VV +L+NA   + L V
Sbjct: 1735 LDGLSHADVVNLLKNAYGRIILQV 1758



 Score = 45.4 bits (106), Expect = 1e-04
 Identities = 36/119 (30%), Positives = 58/119 (48%), Gaps = 10/119 (8%)

Query: 22   QEPFKVRLHLAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIP 81
            Q P KVRL + +D    ++++ + +           V ++++   G GLSI G   +   
Sbjct: 1507 QTPQKVRLVVYRDEAHYRDEENLEIF---------PVDLQKKAGRGLGLSIVG-KRNGSG 1556

Query: 82   VVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSFLK 140
            V +S I K   A+L G L  GD IL +NG ++R    E V  +L+ A   V L +  L+
Sbjct: 1557 VFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVATILKCAQGLVQLEIGRLR 1615



 Score = 40.4 bits (93), Expect = 0.004
 Identities = 25/72 (34%), Positives = 40/72 (55%), Gaps = 3/72 (4%)

Query: 65  VGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQV 124
           VG  G S  G A     + V  I     A  +G + + D I+ ++G+N++   + +VV+V
Sbjct: 381 VGYVGTSHTGEASG---IYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFANHDVVEV 437

Query: 125 LRNAGEEVTLTV 136
           LRNAG+ V LT+
Sbjct: 438 LRNAGQVVHLTL 449



 Score = 33.5 bits (75), Expect = 0.48
 Identities = 22/82 (26%), Positives = 39/82 (47%), Gaps = 1/82 (1%)

Query: 54   GERTVTIRRQTVGGFGLSIKGGAEHN-IPVVVSKISKEQRAELSGLLFIGDAILQINGIN 112
            GE  +    +   G GLS+ G  + + + + V  I+ E  A   G + IGD +L+IN   
Sbjct: 1235 GELHIIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDELLEINNQI 1294

Query: 113  VRKCRHEEVVQVLRNAGEEVTL 134
            +    H+    +++ A  +V L
Sbjct: 1295 LYGRSHQNASAIIKTAPSKVKL 1316


>gi|45827729 scribble isoform b [Homo sapiens]
          Length = 1630

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 34/89 (38%), Positives = 54/89 (60%), Gaps = 10/89 (11%)

Query: 55  ERTVTIRRQTVGGFGLSIKGGAEHNIP-------VVVSKISKEQRAELSGLLFIGDAILQ 107
           E T+TI RQT GG G+SI GG + + P       + +S++S+E  A  +G+  +GD +L+
Sbjct: 726 ELTLTILRQT-GGLGISIAGG-KGSTPYKGDDEGIFISRVSEEGPAARAGVR-VGDKLLE 782

Query: 108 INGINVRKCRHEEVVQVLRNAGEEVTLTV 136
           +NG+ ++   H E V+ LR AG  V + V
Sbjct: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRV 811



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 27/86 (31%), Positives = 44/86 (51%), Gaps = 6/86 (6%)

Query: 55  ERTVTIRRQTVGGFGLSIKGGAEH------NIPVVVSKISKEQRAELSGLLFIGDAILQI 108
           +R V    ++  G G SI GG         +  + VS+I++   A  +G L +GD +L I
Sbjct: 859 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 918

Query: 109 NGINVRKCRHEEVVQVLRNAGEEVTL 134
           NG++V + RH+  V +L  A   + L
Sbjct: 919 NGVDVTEARHDHAVSLLTAASPTIAL 944



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 36/94 (38%), Positives = 48/94 (51%), Gaps = 13/94 (13%)

Query: 60   IRRQTVGG-FGLSIKGGAEHNIP--------VVVSKISKEQRAELSGLLFIGDAILQING 110
            IR    GG  GLSI GG++H+          V +SK+     A  SGL  +GD IL +NG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLR-VGDRILAVNG 1063

Query: 111  INVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPA 144
             +VR   H+E V  L     E++L V   +R PA
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLV---RRDPA 1094



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 9/102 (8%)

Query: 44   ICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIP---------VVVSKISKEQRAE 94
            + V  +P   G R + I++      G+SI+GGA  +           + +SK+S    A 
Sbjct: 1087 LLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAG 1146

Query: 95   LSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTV 136
              G L +G  +L++N  ++    H E VQ+LR+ G+ +T+ V
Sbjct: 1147 RDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188


>gi|45827731 scribble isoform a [Homo sapiens]
          Length = 1655

 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 34/89 (38%), Positives = 54/89 (60%), Gaps = 10/89 (11%)

Query: 55  ERTVTIRRQTVGGFGLSIKGGAEHNIP-------VVVSKISKEQRAELSGLLFIGDAILQ 107
           E T+TI RQT GG G+SI GG + + P       + +S++S+E  A  +G+  +GD +L+
Sbjct: 726 ELTLTILRQT-GGLGISIAGG-KGSTPYKGDDEGIFISRVSEEGPAARAGVR-VGDKLLE 782

Query: 108 INGINVRKCRHEEVVQVLRNAGEEVTLTV 136
           +NG+ ++   H E V+ LR AG  V + V
Sbjct: 783 VNGVALQGAEHHEAVEALRGAGTAVQMRV 811



 Score = 46.2 bits (108), Expect = 7e-05
 Identities = 27/86 (31%), Positives = 44/86 (51%), Gaps = 6/86 (6%)

Query: 55  ERTVTIRRQTVGGFGLSIKGGAEH------NIPVVVSKISKEQRAELSGLLFIGDAILQI 108
           +R V    ++  G G SI GG         +  + VS+I++   A  +G L +GD +L I
Sbjct: 859 QRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSI 918

Query: 109 NGINVRKCRHEEVVQVLRNAGEEVTL 134
           NG++V + RH+  V +L  A   + L
Sbjct: 919 NGVDVTEARHDHAVSLLTAASPTIAL 944



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 36/94 (38%), Positives = 48/94 (51%), Gaps = 13/94 (13%)

Query: 60   IRRQTVGG-FGLSIKGGAEHNIP--------VVVSKISKEQRAELSGLLFIGDAILQING 110
            IR    GG  GLSI GG++H+          V +SK+     A  SGL  +GD IL +NG
Sbjct: 1005 IRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLR-VGDRILAVNG 1063

Query: 111  INVRKCRHEEVVQVLRNAGEEVTLTVSFLKRAPA 144
             +VR   H+E V  L     E++L V   +R PA
Sbjct: 1064 QDVRDATHQEAVSALLRPCLELSLLV---RRDPA 1094



 Score = 43.5 bits (101), Expect = 5e-04
 Identities = 29/102 (28%), Positives = 51/102 (50%), Gaps = 9/102 (8%)

Query: 44   ICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIP---------VVVSKISKEQRAE 94
            + V  +P   G R + I++      G+SI+GGA  +           + +SK+S    A 
Sbjct: 1087 LLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAG 1146

Query: 95   LSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTV 136
              G L +G  +L++N  ++    H E VQ+LR+ G+ +T+ V
Sbjct: 1147 RDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLV 1188


>gi|4759306 lin-7 homolog A [Homo sapiens]
          Length = 233

 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 28/76 (36%), Positives = 44/76 (57%)

Query: 63  QTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVV 122
           +T  G G ++ GG E N P+ +S+I     AE  G L  GD +L +NG++V    HE+ V
Sbjct: 113 KTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAV 172

Query: 123 QVLRNAGEEVTLTVSF 138
           ++L+ A + V L V +
Sbjct: 173 ELLKAAKDSVKLVVRY 188


>gi|11545920 lin-7 homolog B [Homo sapiens]
          Length = 207

 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 28/79 (35%), Positives = 45/79 (56%)

Query: 63  QTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVV 122
           +T  G G +I GG E N P+ +S++     A+  G L  GD +L +NG++V   +HE+ V
Sbjct: 98  KTDEGLGFNIMGGKEQNSPIYISRVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAV 157

Query: 123 QVLRNAGEEVTLTVSFLKR 141
           ++L+ A   V L V +  R
Sbjct: 158 ELLKAAQGSVKLVVRYTPR 176


>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
           sapiens]
          Length = 767

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 39/108 (36%), Positives = 58/108 (53%), Gaps = 12/108 (11%)

Query: 31  LAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKE 90
           +AKD+L   E+D+     EP     R + I R + G  G +I GG E    + +S I   
Sbjct: 340 VAKDLL--GEEDI---PREP-----RRIVIHRGSTG-LGFNIVGG-EDGEGIFISFILAG 387

Query: 91  QRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSF 138
             A+LSG L  GD IL +NG+++R   HE+    L+NAG+ VT+   +
Sbjct: 388 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQY 435



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 16/134 (11%)

Query: 67  GFGLSIKGGA-EHNIP----VVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEV 121
           G G SI GG    +IP    + V+KI +   A   G L IGD IL +N + +    HE+ 
Sbjct: 212 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 271

Query: 122 VQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPN 181
           V  L+N  + V L V+  K + A+L        + AP D ++  S  L +   H +Y   
Sbjct: 272 VAALKNTYDVVYLKVA--KPSNAYL------SDSYAPPDITTSYSQHLDNEISHSSYLGT 323

Query: 182 NTDTLSCSSWPTSP 195
           +  T   +  PTSP
Sbjct: 324 DYPT---AMTPTSP 334


>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
           sapiens]
          Length = 721

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 39/108 (36%), Positives = 58/108 (53%), Gaps = 12/108 (11%)

Query: 31  LAKDILMIQEQDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKE 90
           +AKD+L   E+D+     EP     R + I R + G  G +I GG E    + +S I   
Sbjct: 294 VAKDLL--GEEDI---PREP-----RRIVIHRGSTG-LGFNIVGG-EDGEGIFISFILAG 341

Query: 91  QRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSF 138
             A+LSG L  GD IL +NG+++R   HE+    L+NAG+ VT+   +
Sbjct: 342 GPADLSGELRKGDQILSVNGVDLRNASHEQAAIALKNAGQTVTIIAQY 389



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 43/134 (32%), Positives = 63/134 (47%), Gaps = 16/134 (11%)

Query: 67  GFGLSIKGGA-EHNIP----VVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEV 121
           G G SI GG    +IP    + V+KI +   A   G L IGD IL +N + +    HE+ 
Sbjct: 166 GLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDA 225

Query: 122 VQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPN 181
           V  L+N  + V L V+  K + A+L        + AP D ++  S  L +   H +Y   
Sbjct: 226 VAALKNTYDVVYLKVA--KPSNAYL------SDSYAPPDITTSYSQHLDNEISHSSYLGT 277

Query: 182 NTDTLSCSSWPTSP 195
           +  T   +  PTSP
Sbjct: 278 DYPT---AMTPTSP 288


>gi|119943106 synapse-associated protein 102 isoform a [Homo
           sapiens]
          Length = 817

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 32/90 (35%), Positives = 47/90 (52%), Gaps = 2/90 (2%)

Query: 49  EPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQI 108
           E F    R + + + + G  G +I GG E    + VS I     A+LSG L  GD IL +
Sbjct: 378 EDFTREPRKIILHKGSTG-LGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSV 435

Query: 109 NGINVRKCRHEEVVQVLRNAGEEVTLTVSF 138
           NG+N+R   HE+    L+ AG+ VT+   +
Sbjct: 436 NGVNLRNATHEQAAAALKRAGQSVTIVAQY 465



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 29/76 (38%), Positives = 42/76 (55%), Gaps = 5/76 (6%)

Query: 67  GFGLSIKGG-AEHNIP----VVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEV 121
           G G SI GG    +IP    + ++KI +   A+  G L IGD +L +N  N++  RHEE 
Sbjct: 235 GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNLQDVRHEEA 294

Query: 122 VQVLRNAGEEVTLTVS 137
           V  L+N  + V L V+
Sbjct: 295 VASLKNTSDMVYLKVA 310


>gi|8922944 lin-7 homolog C [Homo sapiens]
          Length = 197

 Score = 53.1 bits (126), Expect = 6e-07
 Identities = 28/76 (36%), Positives = 44/76 (57%)

Query: 63  QTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVV 122
           +T  G G +I GG E N P+ +S+I     A+  G L  GD +L +NG++V    HE+ V
Sbjct: 98  KTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAV 157

Query: 123 QVLRNAGEEVTLTVSF 138
           ++L+ A  +V L V +
Sbjct: 158 ELLKAAQGKVKLVVRY 173


>gi|119943108 synapse-associated protein 102 isoform b [Homo
           sapiens]
          Length = 512

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 29/72 (40%), Positives = 40/72 (55%), Gaps = 1/72 (1%)

Query: 67  GFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLR 126
           G G +I GG E    + VS I     A+LSG L  GD IL +NG+N+R   HE+    L+
Sbjct: 58  GLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALK 116

Query: 127 NAGEEVTLTVSF 138
            AG+ VT+   +
Sbjct: 117 RAGQSVTIVAQY 128


>gi|13376349 PDZ domain containing 7 [Homo sapiens]
          Length = 517

 Score = 52.8 bits (125), Expect = 8e-07
 Identities = 33/120 (27%), Positives = 57/120 (47%), Gaps = 15/120 (12%)

Query: 57  TVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKC 116
           +V + +   G  G S++GG+EH + + VSK+ +   AE +GL  +GD I ++NG+++   
Sbjct: 86  SVRVEKSPAGRLGFSVRGGSEHGLGIFVSKVEEGSSAERAGLC-VGDKITEVNGLSLEST 144

Query: 117 RHEEVVQVLRNAGEEVTLTVSFLKRAPAFL-------------KLPLNEDCACAPSDQSS 163
                V+VL  +   + + V  + R P                +  + E C   PSD SS
Sbjct: 145 TMGSAVKVL-TSSSRLHMMVRRMGRVPGIKFSKEKTTWVDVVNRRLVVEKCGSTPSDTSS 203



 Score = 45.8 bits (107), Expect = 9e-05
 Identities = 27/86 (31%), Positives = 47/86 (54%), Gaps = 3/86 (3%)

Query: 69  GLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEVVQVLRNA 128
           G +I+GG E  + + VSK+     AE +G+  +GD +L  NG+      H + V+VL+  
Sbjct: 223 GFNIRGGKEFGLGIYVSKVDHGGLAEENGIK-VGDQVLAANGVRFDDISHSQAVEVLKGQ 281

Query: 129 GEEVTLTVSFLKRAPAFLKLPLNEDC 154
              + LT+    R PA+ ++ ++E C
Sbjct: 282 -THIMLTIKETGRYPAYKEM-VSEYC 305


>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
          Length = 749

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/98 (35%), Positives = 51/98 (52%), Gaps = 7/98 (7%)

Query: 41  QDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLF 100
           Q  + + GEP     R V + + + G  G +I GG E    + VS I     A+LSG L 
Sbjct: 307 QRAVSLEGEP-----RKVVLHKGSTG-LGFNIVGG-EDGEGIFVSFILAGGPADLSGELQ 359

Query: 101 IGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSF 138
            GD IL +NGI++R   HE+    L+ AG+ VT+   +
Sbjct: 360 RGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQY 397



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 43/135 (31%), Positives = 60/135 (44%), Gaps = 16/135 (11%)

Query: 67  GFGLSIKGGA-EHNIP----VVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEV 121
           G G SI GG    +IP    + V+KI     A+  G L +GD +L +N  ++ +  HEE 
Sbjct: 151 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 210

Query: 122 VQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPN 181
           V +L+N  E V L V   K    ++  P        P D +   S P+ +   HL    N
Sbjct: 211 VAILKNTSEVVYLKVG--KPTTIYMTDPY------GPPDITHSYSPPMEN---HLLSGNN 259

Query: 182 NTDTLSCSSWPTSPG 196
            T     S  P SPG
Sbjct: 260 GTLEYKTSLPPISPG 274


>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
          Length = 975

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/98 (35%), Positives = 51/98 (52%), Gaps = 7/98 (7%)

Query: 41  QDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLF 100
           Q  + + GEP     R V + + + G  G +I GG E    + VS I     A+LSG L 
Sbjct: 515 QRAVSLEGEP-----RKVVLHKGSTG-LGFNIVGG-EDGEGIFVSFILAGGPADLSGELQ 567

Query: 101 IGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSF 138
            GD IL +NGI++R   HE+    L+ AG+ VT+   +
Sbjct: 568 RGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQY 605



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 43/135 (31%), Positives = 60/135 (44%), Gaps = 16/135 (11%)

Query: 67  GFGLSIKGGA-EHNIP----VVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEV 121
           G G SI GG    +IP    + V+KI     A+  G L +GD +L +N  ++ +  HEE 
Sbjct: 307 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 366

Query: 122 VQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPN 181
           V +L+N  E V L V   K    ++  P        P D +   S P+ +   HL    N
Sbjct: 367 VAILKNTSEVVYLKVG--KPTTIYMTDPY------GPPDITHSYSPPMEN---HLLSGNN 415

Query: 182 NTDTLSCSSWPTSPG 196
            T     S  P SPG
Sbjct: 416 GTLEYKTSLPPISPG 430


>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
          Length = 870

 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 35/98 (35%), Positives = 51/98 (52%), Gaps = 7/98 (7%)

Query: 41  QDVICVSGEPFYSGERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLF 100
           Q  + + GEP     R V + + + G  G +I GG E    + VS I     A+LSG L 
Sbjct: 410 QRAVSLEGEP-----RKVVLHKGSTG-LGFNIVGG-EDGEGIFVSFILAGGPADLSGELQ 462

Query: 101 IGDAILQINGINVRKCRHEEVVQVLRNAGEEVTLTVSF 138
            GD IL +NGI++R   HE+    L+ AG+ VT+   +
Sbjct: 463 RGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQY 500



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 43/135 (31%), Positives = 60/135 (44%), Gaps = 16/135 (11%)

Query: 67  GFGLSIKGGA-EHNIP----VVVSKISKEQRAELSGLLFIGDAILQINGINVRKCRHEEV 121
           G G SI GG    +IP    + V+KI     A+  G L +GD +L +N  ++ +  HEE 
Sbjct: 202 GLGFSIAGGVGNQHIPGDNSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEA 261

Query: 122 VQVLRNAGEEVTLTVSFLKRAPAFLKLPLNEDCACAPSDQSSGTSSPLCDSGLHLNYHPN 181
           V +L+N  E V L V   K    ++  P        P D +   S P+ +   HL    N
Sbjct: 262 VAILKNTSEVVYLKVG--KPTTIYMTDPY------GPPDITHSYSPPMEN---HLLSGNN 310

Query: 182 NTDTLSCSSWPTSPG 196
            T     S  P SPG
Sbjct: 311 GTLEYKTSLPPISPG 325


>gi|41281808 harmonin isoform b3 [Homo sapiens]
          Length = 899

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 26/71 (36%), Positives = 43/71 (60%), Gaps = 1/71 (1%)

Query: 56  RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115
           + V + R    G GLS++GG E    + +S + K  +A+  GL  +GD I++ING ++  
Sbjct: 86  KEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQ-VGDEIVRINGYSISS 144

Query: 116 CRHEEVVQVLR 126
           C HEEV+ ++R
Sbjct: 145 CTHEEVINLIR 155



 Score = 36.6 bits (83), Expect = 0.057
 Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 4/88 (4%)

Query: 55  ERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVR 114
           E+ V I      G G SI  G      + +S +     +   GL  IGD I+++NG++  
Sbjct: 209 EKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLE-IGDQIVEVNGVDFS 267

Query: 115 KCRHEEVVQVLRNAGEEVTLTVSFLKRA 142
              H+E V VL+++    +LT+S +  A
Sbjct: 268 NLDHKEAVNVLKSSR---SLTISIVAAA 292



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 5/89 (5%)

Query: 54  GERTVTIRRQTVGGFGLSIKGGAEHNI-PVVVSKISKEQRAELSGLLFIGDAILQINGIN 112
           G+    +R +  G   L+++GG +  I  VVVS + +   AE  G +  GD I+ ING  
Sbjct: 750 GKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKI 809

Query: 113 VRKCRHEEVVQVLRNA----GEEVTLTVS 137
           V      E    L+ A    G+ + L V+
Sbjct: 810 VTDYTLAEAEAALQKAWNQGGDWIDLVVA 838


>gi|71480164 harmonin isoform a [Homo sapiens]
          Length = 552

 Score = 52.0 bits (123), Expect = 1e-06
 Identities = 26/71 (36%), Positives = 43/71 (60%), Gaps = 1/71 (1%)

Query: 56  RTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVRK 115
           + V + R    G GLS++GG E    + +S + K  +A+  GL  +GD I++ING ++  
Sbjct: 86  KEVRLDRLHPEGLGLSVRGGLEFGCGLFISHLIKGGQADSVGLQ-VGDEIVRINGYSISS 144

Query: 116 CRHEEVVQVLR 126
           C HEEV+ ++R
Sbjct: 145 CTHEEVINLIR 155



 Score = 36.6 bits (83), Expect = 0.057
 Identities = 26/88 (29%), Positives = 43/88 (48%), Gaps = 4/88 (4%)

Query: 55  ERTVTIRRQTVGGFGLSIKGGAEHNIPVVVSKISKEQRAELSGLLFIGDAILQINGINVR 114
           E+ V I      G G SI  G      + +S +     +   GL  IGD I+++NG++  
Sbjct: 209 EKKVFISLVGSRGLGCSISSGPIQKPGIFISHVKPGSLSAEVGLE-IGDQIVEVNGVDFS 267

Query: 115 KCRHEEVVQVLRNAGEEVTLTVSFLKRA 142
              H+E V VL+++    +LT+S +  A
Sbjct: 268 NLDHKEAVNVLKSSR---SLTISIVAAA 292



 Score = 32.0 bits (71), Expect = 1.4
 Identities = 27/89 (30%), Positives = 42/89 (47%), Gaps = 5/89 (5%)

Query: 54  GERTVTIRRQTVGGFGLSIKGGAEHNI-PVVVSKISKEQRAELSGLLFIGDAILQINGIN 112
           G+    +R +  G   L+++GG +  I  VVVS + +   AE  G +  GD I+ ING  
Sbjct: 450 GKDVRLLRIKKEGSLDLALEGGVDSPIGKVVVSAVYERGAAERHGGIVKGDEIMAINGKI 509

Query: 113 VRKCRHEEVVQVLRNA----GEEVTLTVS 137
           V      E    L+ A    G+ + L V+
Sbjct: 510 VTDYTLAEAEAALQKAWNQGGDWIDLVVA 538


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.134    0.413 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,242,082
Number of Sequences: 37866
Number of extensions: 849322
Number of successful extensions: 2235
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 135
Number of HSP's successfully gapped in prelim test: 66
Number of HSP's that attempted gapping in prelim test: 1884
Number of HSP's gapped (non-prelim): 347
length of query: 517
length of database: 18,247,518
effective HSP length: 107
effective length of query: 410
effective length of database: 14,195,856
effective search space: 5820300960
effective search space used: 5820300960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.