Guide to the Human Genome
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Search of human proteins with 90421313

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
         (1480 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|90421313 cystic fibrosis transmembrane conductance regulator ...  2908   0.0  
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor...   414   e-115
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor...   414   e-115
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform...   298   2e-80
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor...   287   5e-77
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor...   285   3e-76
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor...   285   3e-76
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ...   285   3e-76
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]           280   7e-75
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member...   280   1e-74
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor...   279   1e-74
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor...   279   1e-74
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ...   279   2e-74
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor...   276   1e-73
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor...   276   1e-73
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor...   276   1e-73
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor...   276   1e-73
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ...   266   1e-70
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor...   259   1e-68
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor...   252   2e-66
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]           252   2e-66
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor...   250   6e-66
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor...   117   8e-26
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ...   115   2e-25
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s...   115   2e-25
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa...   111   6e-24
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa...   108   3e-23
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ...   107   7e-23
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo...   107   7e-23
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B...   105   3e-22

>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
            sapiens]
          Length = 1480

 Score = 2908 bits (7538), Expect = 0.0
 Identities = 1480/1480 (100%), Positives = 1480/1480 (100%)

Query: 1    MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE 60
            MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE
Sbjct: 1    MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE 60

Query: 61   LASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA 120
            LASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA
Sbjct: 61   LASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA 120

Query: 121  IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL 180
            IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL
Sbjct: 121  IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL 180

Query: 181  VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL 240
            VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL
Sbjct: 181  VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL 240

Query: 241  GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA 300
            GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA
Sbjct: 241  GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA 300

Query: 301  YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQT 360
            YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQT
Sbjct: 301  YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQT 360

Query: 361  WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRK 420
            WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRK
Sbjct: 361  WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRK 420

Query: 421  TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG 480
            TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG
Sbjct: 421  TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG 480

Query: 481  KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
            KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV
Sbjct: 481  KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540

Query: 541  LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
            LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR
Sbjct: 541  LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600

Query: 601  ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNS 660
            ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNS
Sbjct: 601  ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNS 660

Query: 661  ILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ 720
            ILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ
Sbjct: 661  ILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ 720

Query: 721  MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG 780
            MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG
Sbjct: 721  MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG 780

Query: 781  QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESI 840
            QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESI
Sbjct: 781  QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESI 840

Query: 841  PAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN 900
            PAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN
Sbjct: 841  PAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN 900

Query: 901  NSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP 960
            NSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP
Sbjct: 901  NSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP 960

Query: 961  MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATV 1020
            MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATV
Sbjct: 961  MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATV 1020

Query: 1021 PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHK 1080
            PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHK
Sbjct: 1021 PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHK 1080

Query: 1081 ALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIM 1140
            ALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIM
Sbjct: 1081 ALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIM 1140

Query: 1141 STLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK 1200
            STLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK
Sbjct: 1141 STLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK 1200

Query: 1201 DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL 1260
            DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL
Sbjct: 1201 DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL 1260

Query: 1261 LNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD 1320
            LNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD
Sbjct: 1261 LNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD 1320

Query: 1321 EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380
            EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT
Sbjct: 1321 EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380

Query: 1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA 1440
            YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA
Sbjct: 1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA 1440

Query: 1441 ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL 1480
            ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL
Sbjct: 1441 ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL 1480


>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
           [Homo sapiens]
          Length = 859

 Score =  414 bits (1063), Expect = e-115
 Identities = 224/652 (34%), Positives = 368/652 (56%), Gaps = 42/652 (6%)

Query: 4   SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
           +PL+ A++ S++FF W  P+ + G+++RLE  D+Y +   D + +L E+L+  WD+E+  
Sbjct: 11  NPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLR 70

Query: 64  KKN----PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRII---ASYDPDNKEE 116
            +N    P L  A+ +C++  ++  GIF  + E  K +QP+ LG+II    +YDP +   
Sbjct: 71  AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVA 130

Query: 117 RSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKIS 176
            + A      L    ++  +L H   + +   GM++R+AM  +IY+K L+LS+  + K +
Sbjct: 131 LNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTT 190

Query: 177 IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALF 236
            GQ+V+LLSN++NKFD+     HF+W  PLQ   +  L+W  +  S   G+  LI+L   
Sbjct: 191 TGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPL 250

Query: 237 QAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLT 296
           Q+  G++    R + A     R+   +E+I  I+ +K Y WE++   +I NLR+ E+   
Sbjct: 251 QSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKI 310

Query: 297 RKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILR-KIFTTISFCIVLRMAVTRQFP 355
            +++ +R  N ++FF +   +VF++   Y L+  +I   ++F  ++    +R+ VT  FP
Sbjct: 311 LRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFP 370

Query: 356 WAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENV---TAFWEEGFGELFEKA 412
            A++   +++ +I +IQ FL   E       L +    M +V   TAFW+        KA
Sbjct: 371 SAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD--------KA 422

Query: 413 KQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIM 472
            +                       TP L+ ++F +  G+LLAV G  GAGK+SLL  ++
Sbjct: 423 SE-----------------------TPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL 459

Query: 473 GELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISK 532
           GEL PS G +   GRI++ SQ  W+  GT++ NI+FG  Y++ RY  VIKAC L++D+  
Sbjct: 460 GELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL 519

Query: 533 FAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVC 592
             + D  V+G+ G TLSGGQ+AR++LARAVY+DAD+YLLD P   +D    + +FE C+C
Sbjct: 520 LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCIC 579

Query: 593 KLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKL 644
           +++  K  ILVT ++++LK A +ILIL +G     GT++E      DF S L
Sbjct: 580 QILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 114/497 (22%), Positives = 209/497 (42%), Gaps = 62/497 (12%)

Query: 950  HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
            H +    L+     +     G I+N  S D+   D +     F    L    + AIAV A
Sbjct: 172  HMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHF----LWAGPLQAIAVTA 227

Query: 1010 VLQPYIFV---ATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLR 1066
            +L   I +   A + V++  + L++ F +    L+   +         +   + G+  ++
Sbjct: 228  LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287

Query: 1067 AFGRQPYFETLFHKALNLHTANWFLYLSTLR------WFQMRIEMIFVIFFIAVTFISIL 1120
             +  +  F  L    L     +  L  S LR      +F     ++FV F   V   S++
Sbjct: 288  MYAWEKSFSNLITN-LRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVI 346

Query: 1121 TTGEGEGRVGIILTLAMNIMSTLQWAVNSSID-VDSLMRSVSRVFKFIDMPTEGKPTKST 1179
            T      RV + +TL   +  T+     S+I+ V   + S+ R+  F+ +    +     
Sbjct: 347  TAS----RVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQ----- 397

Query: 1180 KPYKNGQLSKVMIIENSHVKKDDIWPSGGQ--MTVKDLTAKYTEGGNA-ILENISFSISP 1236
               +N QL                 PS G+  + V+D TA + +      L+ +SF++ P
Sbjct: 398  ---RNRQL-----------------PSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRP 437

Query: 1237 GQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFI 1295
            G+ + ++G  G+GKS+LLSA L  L  + G + + G                 + Q+ ++
Sbjct: 438  GELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWV 484

Query: 1296 FSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMC 1355
            FSGT R N+   +++  +   KV     L+  ++        V+ D G  LS G K  + 
Sbjct: 485  FSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVN 544

Query: 1356 LARSVLSKAKILLLDEPSAHLD-PVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL 1414
            LAR+V   A I LLD+P + +D  V+  +    + Q   +   IL  H+++ +    Q L
Sbjct: 545  LARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQIL 604

Query: 1415 VIEENKVRQYDSIQKLL 1431
            ++++ K+ Q  +  + L
Sbjct: 605  ILKDGKMVQKGTYTEFL 621



 Score = 74.7 bits (182), Expect = 6e-13
 Identities = 48/135 (35%), Positives = 67/135 (49%), Gaps = 3/135 (2%)

Query: 865 WCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN---NSYAVIITSTSSYYVFYIYVG 921
           W + IFL  +  +  V ++L +  L    N     N   N    +       +   IY G
Sbjct: 711 WIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSG 770

Query: 922 VADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIA 981
           +    +  G  R L + + L+  S+ LH+KM  S+L+AP+   +    G ILNRFSKDI 
Sbjct: 771 LTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIG 830

Query: 982 ILDDLLPLTIFDFIQ 996
            LDDLLPLT  DFIQ
Sbjct: 831 HLDDLLPLTFLDFIQ 845


>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
           [Homo sapiens]
          Length = 1325

 Score =  414 bits (1063), Expect = e-115
 Identities = 224/652 (34%), Positives = 368/652 (56%), Gaps = 42/652 (6%)

Query: 4   SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
           +PL+ A++ S++FF W  P+ + G+++RLE  D+Y +   D + +L E+L+  WD+E+  
Sbjct: 11  NPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLR 70

Query: 64  KKN----PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRII---ASYDPDNKEE 116
            +N    P L  A+ +C++  ++  GIF  + E  K +QP+ LG+II    +YDP +   
Sbjct: 71  AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVA 130

Query: 117 RSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKIS 176
            + A      L    ++  +L H   + +   GM++R+AM  +IY+K L+LS+  + K +
Sbjct: 131 LNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTT 190

Query: 177 IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALF 236
            GQ+V+LLSN++NKFD+     HF+W  PLQ   +  L+W  +  S   G+  LI+L   
Sbjct: 191 TGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPL 250

Query: 237 QAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLT 296
           Q+  G++    R + A     R+   +E+I  I+ +K Y WE++   +I NLR+ E+   
Sbjct: 251 QSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKI 310

Query: 297 RKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILR-KIFTTISFCIVLRMAVTRQFP 355
            +++ +R  N ++FF +   +VF++   Y L+  +I   ++F  ++    +R+ VT  FP
Sbjct: 311 LRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFP 370

Query: 356 WAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENV---TAFWEEGFGELFEKA 412
            A++   +++ +I +IQ FL   E       L +    M +V   TAFW+        KA
Sbjct: 371 SAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD--------KA 422

Query: 413 KQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIM 472
            +                       TP L+ ++F +  G+LLAV G  GAGK+SLL  ++
Sbjct: 423 SE-----------------------TPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL 459

Query: 473 GELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISK 532
           GEL PS G +   GRI++ SQ  W+  GT++ NI+FG  Y++ RY  VIKAC L++D+  
Sbjct: 460 GELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL 519

Query: 533 FAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVC 592
             + D  V+G+ G TLSGGQ+AR++LARAVY+DAD+YLLD P   +D    + +FE C+C
Sbjct: 520 LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCIC 579

Query: 593 KLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKL 644
           +++  K  ILVT ++++LK A +ILIL +G     GT++E      DF S L
Sbjct: 580 QILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631



 Score =  398 bits (1023), Expect = e-110
 Identities = 216/582 (37%), Positives = 339/582 (58%), Gaps = 24/582 (4%)

Query: 865  WCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN---NSYAVIITSTSSYYVFYIYVG 921
            W + IFL  +  +  V ++L +  L    N     N   N    +       +   IY G
Sbjct: 711  WIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSG 770

Query: 922  VADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIA 981
            +    +  G  R L + + L+  S+ LH+KM  S+L+AP+   +    G ILNRFSKDI 
Sbjct: 771  LTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIG 830

Query: 982  ILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLK 1041
             LDDLLPLT  DFIQ LL V+G ++V   + P+I +  VP+ + FI LR YFL+TS+ +K
Sbjct: 831  HLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVK 890

Query: 1042 QLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQM 1101
            +LES  RSP+F+HL +SL+GLWT+RA+  +   + LF    +LH+  WFL+L+T RWF +
Sbjct: 891  RLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAV 950

Query: 1102 RIEMIFVIFFIAVTFIS-ILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSV 1160
            R++ I  +F I V F S IL      G+VG+ L+ A+ +M   QW V  S +V+++M SV
Sbjct: 951  RLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISV 1010

Query: 1161 SRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYT 1220
             RV ++ D+  E       +P                      WP  G +   ++   Y+
Sbjct: 1011 ERVIEYTDLEKEAPWEYQKRP-------------------PPAWPHEGVIIFDNVNFMYS 1051

Query: 1221 EGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQ 1280
             GG  +L++++  I   ++VG++GRTG+GKS+L+SA  RL   EG+I ID +    I L 
Sbjct: 1052 PGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLH 1111

Query: 1281 QWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLV 1340
              RK   +IPQ+  +F+GT RKNLDP+ + +D+E+W    EV L+  IE  PGK+D  L 
Sbjct: 1112 DLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELA 1171

Query: 1341 DGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILC 1400
            + G   S G +QL+CLAR++L K +IL++DE +A++DP T ++I++ +++ FA CTV+  
Sbjct: 1172 ESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTI 1231

Query: 1401 EHRIEAMLECQQFLVIEENKVRQYDSIQKLL-NERSLFRQAI 1441
             HR+  +++  + +V++  ++++YD    LL N+ SLF + +
Sbjct: 1232 AHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273



 Score = 90.1 bits (222), Expect = 1e-17
 Identities = 114/497 (22%), Positives = 209/497 (42%), Gaps = 62/497 (12%)

Query: 950  HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
            H +    L+     +     G I+N  S D+   D +     F    L    + AIAV A
Sbjct: 172  HMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHF----LWAGPLQAIAVTA 227

Query: 1010 VLQPYIFV---ATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLR 1066
            +L   I +   A + V++  + L++ F +    L+   +         +   + G+  ++
Sbjct: 228  LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287

Query: 1067 AFGRQPYFETLFHKALNLHTANWFLYLSTLR------WFQMRIEMIFVIFFIAVTFISIL 1120
             +  +  F  L    L     +  L  S LR      +F     ++FV F   V   S++
Sbjct: 288  MYAWEKSFSNLITN-LRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVI 346

Query: 1121 TTGEGEGRVGIILTLAMNIMSTLQWAVNSSID-VDSLMRSVSRVFKFIDMPTEGKPTKST 1179
            T      RV + +TL   +  T+     S+I+ V   + S+ R+  F+ +    +     
Sbjct: 347  TAS----RVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQ----- 397

Query: 1180 KPYKNGQLSKVMIIENSHVKKDDIWPSGGQ--MTVKDLTAKYTEGGNA-ILENISFSISP 1236
               +N QL                 PS G+  + V+D TA + +      L+ +SF++ P
Sbjct: 398  ---RNRQL-----------------PSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRP 437

Query: 1237 GQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFI 1295
            G+ + ++G  G+GKS+LLSA L  L  + G + + G                 + Q+ ++
Sbjct: 438  GELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWV 484

Query: 1296 FSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMC 1355
            FSGT R N+   +++  +   KV     L+  ++        V+ D G  LS G K  + 
Sbjct: 485  FSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVN 544

Query: 1356 LARSVLSKAKILLLDEPSAHLD-PVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL 1414
            LAR+V   A I LLD+P + +D  V+  +    + Q   +   IL  H+++ +    Q L
Sbjct: 545  LARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQIL 604

Query: 1415 VIEENKVRQYDSIQKLL 1431
            ++++ K+ Q  +  + L
Sbjct: 605  ILKDGKMVQKGTYTEFL 621



 Score = 73.2 bits (178), Expect = 2e-12
 Identities = 110/533 (20%), Positives = 222/533 (41%), Gaps = 76/533 (14%)

Query: 119  IAIYLGIGLC--LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKIS 176
            + IY G+ +   L  I R+LL+        ++ +     + + +++  LK      D+  
Sbjct: 765  LGIYSGLTVATVLFGIARSLLVF-------YVLVNSSQTLHNKMFESILKAPVLFFDRNP 817

Query: 177  IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALF 236
            IG++++  S ++   D+ L L    +I  L    ++G++   +    +  +  L+ L + 
Sbjct: 818  IGRILNRFSKDIGHLDDLLPLTFLDFIQTL--LQVVGVVSVAVAVIPWIAIP-LVPLGII 874

Query: 237  QAGLGRMMMKY-RDQRAGKISERLVITSEMIENIQ---SVKAYCWEEAMEKMIENLRQTE 292
               L R  ++  RD +  + + R  + S +  ++Q   +++AY  EE  +++ +  +   
Sbjct: 875  FIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLH 934

Query: 293  LKLTRKAAYVRYFNSSAFF------FSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVL 346
             +     A+  +  +S +F          FV+ ++     L K +   ++   +S+ + L
Sbjct: 935  SE-----AWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTL 989

Query: 347  RMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFG 406
                   F W V+    S    N +    +  EY  LE      E       A+  EG  
Sbjct: 990  M----GMFQWCVR---QSAEVENMMISVERVIEYTDLEKE-APWEYQKRPPPAWPHEGV- 1040

Query: 407  ELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTP----VLKDINFKIERGQLLAVAGSTGA 462
                                 + F N + + +P    VLK +   I+  + + + G TGA
Sbjct: 1041 ---------------------IIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGA 1079

Query: 463  GKTSLLMVIMGELEPSEGKI-----------KHSGR--ISFCSQFSWIMPGTIKENIIFG 509
            GK+SL+  +    EP EGKI            H  R  +S   Q   +  GT+++N+   
Sbjct: 1080 GKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPF 1138

Query: 510  VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLY 569
              + +    + ++  QL+E I     K +  L E G   S GQR  + LARA+ +   + 
Sbjct: 1139 NEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQIL 1198

Query: 570  LLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEG 622
            ++D     +D  T+ E+ +  + +  A+ T + +  ++  +  +DKI++L  G
Sbjct: 1199 IIDEATANVDPRTD-ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSG 1250


>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
            [Homo sapiens]
          Length = 1437

 Score =  298 bits (764), Expect = 2e-80
 Identities = 175/595 (29%), Positives = 316/595 (53%), Gaps = 23/595 (3%)

Query: 846  WNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAV 905
            W+ Y  YI      +  L+  + +F+  V ++    W L     Q  GN+T +R N  +V
Sbjct: 843  WSVYGVYIQAAGGPLAFLV-IMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSV 901

Query: 906  IITSTSSYYVFY---IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMS 962
              +   + ++ Y   IY      +L +   RG+  V   +  S  LH ++   +L++PM 
Sbjct: 902  SDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMK 961

Query: 963  TLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPV 1022
              +T   G ILNRFSKD+  +D  LP     FIQ +++V   + ++A + P+  VA  P+
Sbjct: 962  FFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPL 1021

Query: 1023 IVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
            ++ F +L        ++LK+L++  +SP  +H+ +S++GL T+ A+ +   F   + + L
Sbjct: 1022 VILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELL 1081

Query: 1083 NLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGE-GEGRVGIILTLAMNIMS 1141
            + + A +FL+   +RW  +R+++I +        + +L  G+      G+ ++ A+ +  
Sbjct: 1082 DDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTG 1141

Query: 1142 TLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKD 1201
              Q+ V  + + ++   SV R+  +I   +   P +               I+N     D
Sbjct: 1142 LFQFTVRLASETEARFTSVERINHYIKTLSLEAPAR---------------IKNKAPSPD 1186

Query: 1202 DIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261
              WP  G++T ++   +Y E    +L+ +SF+I P +++G++GRTGSGKS+L  A  RL+
Sbjct: 1187 --WPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLV 1244

Query: 1262 NTEGE-IQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD 1320
               G  I+IDGV    I L   R    +IPQ+  +FSGT R NLDP+ Q+++ +IW   +
Sbjct: 1245 ELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALE 1304

Query: 1321 EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380
               ++  I Q P KL+  +++ G   S G +QL+C+AR++L   KIL+LDE +A +D  T
Sbjct: 1305 RTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTET 1364

Query: 1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
              +I+ T+++AFADCT++   HR+  +L   + +V+ + +V ++D+   LL+  S
Sbjct: 1365 DLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS 1419



 Score =  243 bits (621), Expect = 8e-64
 Identities = 172/689 (24%), Positives = 333/689 (48%), Gaps = 60/689 (8%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQ-RLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
           P++ A + S + FSW   + R  +++  L + D++ +   +S+D    +LER W  EL +
Sbjct: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEEL-N 158

Query: 64  KKNPKLINALRRCFFW---RFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA 120
           +  P   +  R  + +   R +   + L + ++     P  + + +  Y    +     +
Sbjct: 159 EVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYS 218

Query: 121 IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL 180
           + L +GL L  IVR+  L       +  G+++R A+ ++ +KK LKL +  + + S+G+L
Sbjct: 219 LLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN--IKEKSLGEL 276

Query: 181 VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL 240
           +++ SN+  +  E  A+   +   P  V  ++G+I+ ++       LG  + +  + A +
Sbjct: 277 INICSNDGQRMFEAAAVGSLLAGGP--VVAILGMIYNVIILGPTGFLGSAVFILFYPAMM 334

Query: 241 --GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
              R+   +R +      ER+   +E++  I+ +K Y W +A  + ++ +R+ E ++  K
Sbjct: 335 FASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEK 394

Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK----GIILRKIFTTISFCIVLRMAVTRQF 354
           A Y   F S     +   VV  SV+ +++       +   + FT ++    +  A+ +  
Sbjct: 395 AGY---FQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFAL-KVT 450

Query: 355 PWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTT--EVVMENVTAFWEEGFGELF--- 409
           P++V++  ++  A+++ +     +E   ++    +   ++ M+N T  W+     +    
Sbjct: 451 PFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSP 510

Query: 410 -----------------EKAKQ-------------------NNNNRKTSNGDDSLFFSNF 433
                            EK +Q                   +++ R +   ++       
Sbjct: 511 KLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLG 570

Query: 434 SLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQ 493
            L     L  I+ +I+ G+L+ + GS G+GKTSL+  I+G++   EG I  SG  ++ +Q
Sbjct: 571 HLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQ 630

Query: 494 FSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQR 553
            +WI+  T+++NI+FG  YDE RY SV+ +C L  D++     D   +GE G  LSGGQR
Sbjct: 631 QAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQR 690

Query: 554 ARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKA 613
            RISLARA+Y D  +Y+LD P   LD      IF S + K + +KT + VT ++++L   
Sbjct: 691 QRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDC 750

Query: 614 DKILILHEGSSYFYGTFSELQNLQPDFSS 642
           D+++ + EG     GT  EL NL  D+++
Sbjct: 751 DEVIFMKEGCITERGTHEELMNLNGDYAT 779



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 54/208 (25%), Positives = 103/208 (49%), Gaps = 15/208 (7%)

Query: 1227 LENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITLQQWRKA 1285
            L +I   I  G+ VG+ G  GSGK++L+SA L ++   EG I I G              
Sbjct: 578  LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT------------- 624

Query: 1286 FGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCV 1345
            F  + Q+ +I + T R N+   +++ ++    V +   LR  +   P      + + G  
Sbjct: 625  FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGAN 684

Query: 1346 LSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADCTVILCEHRI 1404
            LS G +Q + LAR++ S   I +LD+P + LD  V   I    +++     TV+   H++
Sbjct: 685  LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQL 744

Query: 1405 EAMLECQQFLVIEENKVRQYDSIQKLLN 1432
            + +++C + + ++E  + +  + ++L+N
Sbjct: 745  QYLVDCDEVIFMKEGCITERGTHEELMN 772



 Score = 69.3 bits (168), Expect = 3e-11
 Identities = 55/224 (24%), Positives = 104/224 (46%), Gaps = 29/224 (12%)

Query: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
            VLK ++F I+  + + + G TG+GK+SL M +   +E S G IK  G             
Sbjct: 1209 VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRS 1268

Query: 487  RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
            ++S   Q   +  GT++ N+     Y E +    ++   ++E I++   K    + E G 
Sbjct: 1269 KLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328

Query: 547  TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
              S G+R  + +ARA+ +   + +LD     +D  T+  I E+ + +  A+ T + +  +
Sbjct: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQET-IREAFADCTMLTIAHR 1387

Query: 607  MEHLKKADKILILHEG---------------SSYFYGTFSELQN 635
            +  +  +D+I++L +G               SS FY  F+  +N
Sbjct: 1388 LHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAEN 1431


>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2B [Homo sapiens]
          Length = 1549

 Score =  287 bits (735), Expect = 5e-77
 Identities = 190/648 (29%), Positives = 327/648 (50%), Gaps = 45/648 (6%)

Query: 797  APQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTT---WNTYLRYI 853
            A Q  L    +     S+E   ++ +E  EE+ +E   D+M ++  + T   W T  RY+
Sbjct: 927  ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 986

Query: 854  TVHKSLIFVLIWCLVIFLAEVAASLVVL---WLLGNTPLQDKGNSTHSRNNSYAVIITST 910
            T      F+LI  L+IF   +  S++V    WL   T       S +S NN+      + 
Sbjct: 987  T--SGGFFLLI--LMIFSKLLKHSVIVAIDYWLATWT-------SEYSINNTGK----AD 1031

Query: 911  SSYYV--FYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
             +YYV  F I  G    L  +     L +    +T +K LHH +L+ ++  P+   +T  
Sbjct: 1032 QTYYVAGFSILCGAGIFLCLV---TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTP 1088

Query: 969  AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
             G ILNRFS D  I+D  +P T+    +  L+ + AI +++   P   VA +P+ VAF  
Sbjct: 1089 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYF 1148

Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
            ++ YF   S+ L++L+   + P+  H   + +GL T+RAF  +  F+    +  + +   
Sbjct: 1149 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1208

Query: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVN 1148
            +    +  RW ++R + +     +  +  SI +     G VG+ L  A+ I + L W V 
Sbjct: 1209 YLFLSAANRWLEVRTDYLGACIVLTASIASI-SGSSNSGLVGLGLLYALTITNYLNWVVR 1267

Query: 1149 SSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGG 1208
            +  D++  M +V +V  F+ M +E            G +    + E+        WP  G
Sbjct: 1268 NLADLEVQMGAVKKVNSFLTMESENY---------EGTMDPSQVPEH--------WPQEG 1310

Query: 1209 QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEI 1267
            ++ + DL  +Y      +L+++   I PGQ+VG+ GRTGSGKS+L  AF R+++  +G+I
Sbjct: 1311 EIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKI 1370

Query: 1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSV 1327
             IDG+    + L   R    +I Q   +FSG+ R NLDP  + +D  +W+  +   L+++
Sbjct: 1371 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNM 1430

Query: 1328 IEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387
            ++  PG LD V+ +GG   S G +QL CLAR+ + K+ IL++DE +A +D  T  I+++ 
Sbjct: 1431 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1490

Query: 1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
            +  AFAD TV+   HR+  +L     +V++   + +YD+ + LL + +
Sbjct: 1491 VMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEN 1538



 Score =  213 bits (541), Expect = 1e-54
 Identities = 177/686 (25%), Positives = 324/686 (47%), Gaps = 67/686 (9%)

Query: 10  SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
           +++SK  + W   ++   +++ ++L  I ++P    +V +   L +  E E  +++A   
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYE-EQKKKVADHP 279

Query: 66  N--PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDP------------ 111
           N  P +  A+ R F    +    F YL ++     PL +  I+   +             
Sbjct: 280 NRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGIS 339

Query: 112 ---DNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLS 168
               +KE    A  L + L L  I++   L  + +     G+ +R A+ ++IY K L+LS
Sbjct: 340 ETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLS 399

Query: 169 SRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG 226
           +  L   ++++GQ+ +L++   N+    L L   +W  P+Q+ + + L++ LL +SA  G
Sbjct: 400 TSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVG 459

Query: 227 LGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIE 286
              +++LA  Q  +   + + +       +ERL  T+E+++ I+ +K Y WE    K +E
Sbjct: 460 AAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVE 519

Query: 287 NLRQTELKLTRKAAYVRYFNSSAFFFSGFFV--VFLSVLPYALIKGIILR--KIFTTISF 342
             R  EL   +   +  Y + S F  +   +  V  + + +A   G  L+  + F ++S 
Sbjct: 520 ETRMKELSSLK--TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577

Query: 343 CIVLRMAVTRQF--PWAVQTWYDSLGAINKIQDFLQKQE-----YKTLEYNLTTTEV--- 392
             +L   VT  F     V+    ++ ++ K+ +FL   E     ++T E +L        
Sbjct: 578 FHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKH 634

Query: 393 --VMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN--FSL-LGTPVLKDINFK 447
             V        + G   L    +     R     D ++  +N  FS   G   L +I+ +
Sbjct: 635 TGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIR 694

Query: 448 IERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-----------------RISF 490
           I  GQL  + G  G GK+SLL+ I+GE++  EGK+  S                   +++
Sbjct: 695 IPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAY 754

Query: 491 CSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSG 550
            +Q  W++  T++ENI FG  +++ RY++V  AC L+ DI      D   +GE GI LSG
Sbjct: 755 AAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSG 814

Query: 551 GQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMAN--KTRILVTSKME 608
           GQR RI +ARA+Y++ ++  LD PF  LD+     + +  + K + +  +T +LVT K++
Sbjct: 815 GQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQ 874

Query: 609 HLKKADKILILHEGSSYFYGTFSELQ 634
           +L  AD I+ + +GS    GT  ++Q
Sbjct: 875 YLTHADWIIAMKDGSVLREGTLKDIQ 900



 Score = 82.0 bits (201), Expect = 4e-15
 Identities = 84/384 (21%), Positives = 156/384 (40%), Gaps = 47/384 (12%)

Query: 263  SEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSV 322
            SE  E + +++A+  E   ++     R  EL  T   AY+    ++ +       +   +
Sbjct: 1176 SETAEGLTTIRAFRHETRFKQ-----RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230

Query: 323  LPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQE 379
            +  A I  I        +   ++  + +T    W V+   D    +GA+ K+  FL    
Sbjct: 1231 VLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL---- 1286

Query: 380  YKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGT 438
              T+E       +    V   W +EG  ++ +   +  NN K                  
Sbjct: 1287 --TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK------------------ 1326

Query: 439  PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------ 486
            PVLK +   I+ GQ + + G TG+GK+SL +     ++  +GKI   G            
Sbjct: 1327 PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLR 1386

Query: 487  -RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
             R+S   Q   +  G+I+ N+       + R    ++  QL+  +       + V+ EGG
Sbjct: 1387 SRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1446

Query: 546  ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
               S GQR    LARA  + + + ++D     +D+ TE  I +  V    A++T + +  
Sbjct: 1447 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE-NILQKVVMTAFADRTVVTIAH 1505

Query: 606  KMEHLKKADKILILHEGSSYFYGT 629
            ++  +  AD ++++  G+   Y T
Sbjct: 1506 RVHTILTADLVIVMKRGNILEYDT 1529



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 66/293 (22%), Positives = 129/293 (44%), Gaps = 28/293 (9%)

Query: 1213 KDLTAKYTEG------GNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
            +D+  K T G      G A L NI   I  GQ   ++G+ G GKS+LL A L  + T EG
Sbjct: 668  EDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEG 727

Query: 1266 EIQIDGVSWDSITLQQWRK----AFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADE 1321
            ++    V+    + +  R     +     QK ++ + T  +N+     ++ Q    V D 
Sbjct: 728  KVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDA 787

Query: 1322 VGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD-PVT 1380
              L+  I+  P      + + G  LS G +Q +C+AR++     I+ LD+P + LD  ++
Sbjct: 788  CSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLS 847

Query: 1381 YQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVRQ--------------Y 1424
              +++  + +   D   T++L  H+++ +      + +++  V +              Y
Sbjct: 848  DHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELY 907

Query: 1425 DSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQD 1477
            +  + L+N +    +    +D+  L          S+   A +++E EEE ++
Sbjct: 908  EHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960


>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A-delta-14 [Homo sapiens]
          Length = 1513

 Score =  285 bits (728), Expect = 3e-76
 Identities = 190/648 (29%), Positives = 327/648 (50%), Gaps = 45/648 (6%)

Query: 797  APQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTT---WNTYLRYI 853
            A Q  L    +     S+E   ++ +E  EE+ +E   D+M ++  + T   W T  RY+
Sbjct: 891  ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 950

Query: 854  TVHKSLIFVLIWCLVIFLAEVAASLVVL---WLLGNTPLQDKGNSTHSRNNSYAVIITST 910
            T      F+LI  L+IF   +  S++V    WL   T       S +S NN+      + 
Sbjct: 951  T--SGGFFLLI--LMIFSKLLKHSVIVAIDYWLATWT-------SEYSINNTGK----AD 995

Query: 911  SSYYV--FYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
             +YYV  F I  G    L  +     L +    +T +K LHH +L+ ++  P+   +T  
Sbjct: 996  QTYYVAGFSILCGAGIFLCLV---TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTP 1052

Query: 969  AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
             G ILNRFS D  I+D  +P T+    +  L+ + AI +++   P   VA +P+ VAF  
Sbjct: 1053 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYF 1112

Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
            ++ YF   S+ L++L+   + P+  H   + +GL T+RAF  +  F+    +  + +   
Sbjct: 1113 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1172

Query: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVN 1148
            +    +  RW ++R + +     +  +  SI +     G VG+ L  A+ I + L W V 
Sbjct: 1173 YLFLSAANRWLEVRTDYLGACIVLTASIASI-SGSSNSGLVGLGLLYALTITNYLNWVVR 1231

Query: 1149 SSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGG 1208
            +  D++  M +V +V  F+ M +E            G +    + E+        WP  G
Sbjct: 1232 NLADLEVQMGAVKKVNSFLTMESENY---------EGTMDPSQVPEH--------WPQEG 1274

Query: 1209 QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEI 1267
            ++ + DL  +Y      +L+++   I PGQ+VG+ GRTGSGKS+L  AF R+++  +G+I
Sbjct: 1275 EIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKI 1334

Query: 1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSV 1327
             IDG+    + L   R    +I Q   +FSG+ R NLDP  + +D  +W+  +   L+++
Sbjct: 1335 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNM 1394

Query: 1328 IEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387
            ++  PG LD V+ +GG   S G +QL CLAR+ + K+ IL++DE +A +D  T  I+++ 
Sbjct: 1395 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1454

Query: 1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
            +  AFAD TV+   HR+ ++++    LV  E  + + D++  LL  ++
Sbjct: 1455 VMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKN 1502



 Score =  216 bits (551), Expect = 1e-55
 Identities = 178/674 (26%), Positives = 321/674 (47%), Gaps = 79/674 (11%)

Query: 10  SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
           +++SK  + W   ++   +++ ++L  I ++P    +V +   L +  E E  +++A   
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYE-EQKKKVADHP 279

Query: 66  N--PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDP------------ 111
           N  P +  A+ R F    +    F YL ++     PL +  I+   +             
Sbjct: 280 NRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGIS 339

Query: 112 ---DNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLS 168
               +KE    A  L + L L  I++   L  + +     G+ +R A+ ++IY K L+LS
Sbjct: 340 ETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLS 399

Query: 169 SRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG 226
           +  L   ++++GQ+ +L++   N+    L L   +W  P+Q+ + + L++ LL +SA  G
Sbjct: 400 TSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVG 459

Query: 227 LGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIE 286
              +++LA  Q  +   + + +       +ERL  T+E+++ I+ +K Y WE    K +E
Sbjct: 460 AAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVE 519

Query: 287 NLRQTELKLTRKAAYVRYFNSSAFFFSGFFV--VFLSVLPYALIKGIILR--KIFTTISF 342
             R  EL   +   +  Y + S F  +   +  V  + + +A   G  L+  + F ++S 
Sbjct: 520 ETRMKELSSLK--TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577

Query: 343 CIVLRMAVTRQF--PWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAF 400
             +L   VT  F     V+    ++ ++ K+ +FL   E                     
Sbjct: 578 FHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDS---------------- 618

Query: 401 WEEGFGEL-FEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGS 459
           W  G   L FE  K++      +NG    +FS  S L T  L +I+ +I  GQL  + G 
Sbjct: 619 WRTGESSLPFESCKKHTG--VVTNG----YFSWGSGLAT--LSNIDIRIPTGQLTMIVGQ 670

Query: 460 TGAGKTSLLMVIMGELEPSEGKIKHSG-----------------RISFCSQFSWIMPGTI 502
            G GK+SLL+ I+GE++  EGK+  S                   +++ +Q  W++  T+
Sbjct: 671 VGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATV 730

Query: 503 KENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAV 562
           +ENI FG  +++ RY++V  AC L+ DI      D   +GE GI LSGGQR RI +ARA+
Sbjct: 731 EENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARAL 790

Query: 563 YKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMAN--KTRILVTSKMEHLKKADKILILH 620
           Y++ ++  LD PF  LD+     + +  + K + +  +T +LVT K+++L  AD I+ + 
Sbjct: 791 YQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMK 850

Query: 621 EGSSYFYGTFSELQ 634
           +GS    GT  ++Q
Sbjct: 851 DGSVLREGTLKDIQ 864



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 83/377 (22%), Positives = 152/377 (40%), Gaps = 47/377 (12%)

Query: 263  SEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSV 322
            SE  E + +++A+  E   ++     R  EL  T   AY+    ++ +       +   +
Sbjct: 1140 SETAEGLTTIRAFRHETRFKQ-----RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1194

Query: 323  LPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQE 379
            +  A I  I        +   ++  + +T    W V+   D    +GA+ K+  FL    
Sbjct: 1195 VLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL---- 1250

Query: 380  YKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGT 438
              T+E       +    V   W +EG  ++ +   +  NN K                  
Sbjct: 1251 --TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK------------------ 1290

Query: 439  PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------ 486
            PVLK +   I+ GQ + + G TG+GK+SL +     ++  +GKI   G            
Sbjct: 1291 PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLR 1350

Query: 487  -RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
             R+S   Q   +  G+I+ N+       + R    ++  QL+  +       + V+ EGG
Sbjct: 1351 SRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1410

Query: 546  ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
               S GQR    LARA  + + + ++D     +D+ TE  I +  V    A++T + +  
Sbjct: 1411 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE-NILQKVVMTAFADRTVVTIAH 1469

Query: 606  KMEHLKKADKILILHEG 622
            ++  +  A  +L+  EG
Sbjct: 1470 RVSSIMDAGLVLVFSEG 1486



 Score = 70.9 bits (172), Expect = 9e-12
 Identities = 70/309 (22%), Positives = 133/309 (43%), Gaps = 32/309 (10%)

Query: 1201 DDIWPSGGQM----TVKDLTAKYTEG------GNAILENISFSISPGQRVGLLGRTGSGK 1250
            DD W +G       + K  T   T G      G A L NI   I  GQ   ++G+ G GK
Sbjct: 616  DDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGK 675

Query: 1251 STLLSAFLRLLNT-EGEIQIDGVSWDSITLQQWRK----AFGVIPQKVFIFSGTFRKNLD 1305
            S+LL A L  + T EG++    V+    + +  R     +     QK ++ + T  +N+ 
Sbjct: 676  SSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENIT 735

Query: 1306 PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAK 1365
                ++ Q    V D   L+  I+  P      + + G  LS G +Q +C+AR++     
Sbjct: 736  FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTN 795

Query: 1366 ILLLDEPSAHLD-PVTYQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVR 1422
            I+ LD+P + LD  ++  +++  + +   D   T++L  H+++ +      + +++  V 
Sbjct: 796  IVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVL 855

Query: 1423 Q--------------YDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALK 1468
            +              Y+  + L+N +    +    +D+  L          S+   A ++
Sbjct: 856  REGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQME 915

Query: 1469 EETEEEVQD 1477
            +E EEE ++
Sbjct: 916  DEDEEEEEE 924


>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A [Homo sapiens]
          Length = 1549

 Score =  285 bits (728), Expect = 3e-76
 Identities = 190/648 (29%), Positives = 327/648 (50%), Gaps = 45/648 (6%)

Query: 797  APQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTT---WNTYLRYI 853
            A Q  L    +     S+E   ++ +E  EE+ +E   D+M ++  + T   W T  RY+
Sbjct: 927  ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 986

Query: 854  TVHKSLIFVLIWCLVIFLAEVAASLVVL---WLLGNTPLQDKGNSTHSRNNSYAVIITST 910
            T      F+LI  L+IF   +  S++V    WL   T       S +S NN+      + 
Sbjct: 987  T--SGGFFLLI--LMIFSKLLKHSVIVAIDYWLATWT-------SEYSINNTGK----AD 1031

Query: 911  SSYYV--FYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
             +YYV  F I  G    L  +     L +    +T +K LHH +L+ ++  P+   +T  
Sbjct: 1032 QTYYVAGFSILCGAGIFLCLV---TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTP 1088

Query: 969  AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
             G ILNRFS D  I+D  +P T+    +  L+ + AI +++   P   VA +P+ VAF  
Sbjct: 1089 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYF 1148

Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
            ++ YF   S+ L++L+   + P+  H   + +GL T+RAF  +  F+    +  + +   
Sbjct: 1149 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1208

Query: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVN 1148
            +    +  RW ++R + +     +  +  SI +     G VG+ L  A+ I + L W V 
Sbjct: 1209 YLFLSAANRWLEVRTDYLGACIVLTASIASI-SGSSNSGLVGLGLLYALTITNYLNWVVR 1267

Query: 1149 SSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGG 1208
            +  D++  M +V +V  F+ M +E            G +    + E+        WP  G
Sbjct: 1268 NLADLEVQMGAVKKVNSFLTMESENY---------EGTMDPSQVPEH--------WPQEG 1310

Query: 1209 QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEI 1267
            ++ + DL  +Y      +L+++   I PGQ+VG+ GRTGSGKS+L  AF R+++  +G+I
Sbjct: 1311 EIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKI 1370

Query: 1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSV 1327
             IDG+    + L   R    +I Q   +FSG+ R NLDP  + +D  +W+  +   L+++
Sbjct: 1371 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNM 1430

Query: 1328 IEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387
            ++  PG LD V+ +GG   S G +QL CLAR+ + K+ IL++DE +A +D  T  I+++ 
Sbjct: 1431 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1490

Query: 1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
            +  AFAD TV+   HR+ ++++    LV  E  + + D++  LL  ++
Sbjct: 1491 VMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKN 1538



 Score =  213 bits (541), Expect = 1e-54
 Identities = 177/686 (25%), Positives = 324/686 (47%), Gaps = 67/686 (9%)

Query: 10  SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
           +++SK  + W   ++   +++ ++L  I ++P    +V +   L +  E E  +++A   
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYE-EQKKKVADHP 279

Query: 66  N--PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDP------------ 111
           N  P +  A+ R F    +    F YL ++     PL +  I+   +             
Sbjct: 280 NRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGIS 339

Query: 112 ---DNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLS 168
               +KE    A  L + L L  I++   L  + +     G+ +R A+ ++IY K L+LS
Sbjct: 340 ETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLS 399

Query: 169 SRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG 226
           +  L   ++++GQ+ +L++   N+    L L   +W  P+Q+ + + L++ LL +SA  G
Sbjct: 400 TSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVG 459

Query: 227 LGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIE 286
              +++LA  Q  +   + + +       +ERL  T+E+++ I+ +K Y WE    K +E
Sbjct: 460 AAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVE 519

Query: 287 NLRQTELKLTRKAAYVRYFNSSAFFFSGFFV--VFLSVLPYALIKGIILR--KIFTTISF 342
             R  EL   +   +  Y + S F  +   +  V  + + +A   G  L+  + F ++S 
Sbjct: 520 ETRMKELSSLK--TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577

Query: 343 CIVLRMAVTRQF--PWAVQTWYDSLGAINKIQDFLQKQE-----YKTLEYNLTTTEV--- 392
             +L   VT  F     V+    ++ ++ K+ +FL   E     ++T E +L        
Sbjct: 578 FHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKH 634

Query: 393 --VMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN--FSL-LGTPVLKDINFK 447
             V        + G   L    +     R     D ++  +N  FS   G   L +I+ +
Sbjct: 635 TGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIR 694

Query: 448 IERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-----------------RISF 490
           I  GQL  + G  G GK+SLL+ I+GE++  EGK+  S                   +++
Sbjct: 695 IPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAY 754

Query: 491 CSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSG 550
            +Q  W++  T++ENI FG  +++ RY++V  AC L+ DI      D   +GE GI LSG
Sbjct: 755 AAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSG 814

Query: 551 GQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMAN--KTRILVTSKME 608
           GQR RI +ARA+Y++ ++  LD PF  LD+     + +  + K + +  +T +LVT K++
Sbjct: 815 GQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQ 874

Query: 609 HLKKADKILILHEGSSYFYGTFSELQ 634
           +L  AD I+ + +GS    GT  ++Q
Sbjct: 875 YLTHADWIIAMKDGSVLREGTLKDIQ 900



 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 83/377 (22%), Positives = 152/377 (40%), Gaps = 47/377 (12%)

Query: 263  SEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSV 322
            SE  E + +++A+  E   ++     R  EL  T   AY+    ++ +       +   +
Sbjct: 1176 SETAEGLTTIRAFRHETRFKQ-----RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230

Query: 323  LPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQE 379
            +  A I  I        +   ++  + +T    W V+   D    +GA+ K+  FL    
Sbjct: 1231 VLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL---- 1286

Query: 380  YKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGT 438
              T+E       +    V   W +EG  ++ +   +  NN K                  
Sbjct: 1287 --TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK------------------ 1326

Query: 439  PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------ 486
            PVLK +   I+ GQ + + G TG+GK+SL +     ++  +GKI   G            
Sbjct: 1327 PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLR 1386

Query: 487  -RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
             R+S   Q   +  G+I+ N+       + R    ++  QL+  +       + V+ EGG
Sbjct: 1387 SRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1446

Query: 546  ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
               S GQR    LARA  + + + ++D     +D+ TE  I +  V    A++T + +  
Sbjct: 1447 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE-NILQKVVMTAFADRTVVTIAH 1505

Query: 606  KMEHLKKADKILILHEG 622
            ++  +  A  +L+  EG
Sbjct: 1506 RVSSIMDAGLVLVFSEG 1522



 Score = 71.2 bits (173), Expect = 7e-12
 Identities = 66/293 (22%), Positives = 129/293 (44%), Gaps = 28/293 (9%)

Query: 1213 KDLTAKYTEG------GNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
            +D+  K T G      G A L NI   I  GQ   ++G+ G GKS+LL A L  + T EG
Sbjct: 668  EDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEG 727

Query: 1266 EIQIDGVSWDSITLQQWRK----AFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADE 1321
            ++    V+    + +  R     +     QK ++ + T  +N+     ++ Q    V D 
Sbjct: 728  KVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDA 787

Query: 1322 VGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD-PVT 1380
              L+  I+  P      + + G  LS G +Q +C+AR++     I+ LD+P + LD  ++
Sbjct: 788  CSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLS 847

Query: 1381 YQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVRQ--------------Y 1424
              +++  + +   D   T++L  H+++ +      + +++  V +              Y
Sbjct: 848  DHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELY 907

Query: 1425 DSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQD 1477
            +  + L+N +    +    +D+  L          S+   A +++E EEE ++
Sbjct: 908  EHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960


>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
            sapiens]
          Length = 1581

 Score =  285 bits (728), Expect = 3e-76
 Identities = 191/660 (28%), Positives = 326/660 (49%), Gaps = 41/660 (6%)

Query: 786  KTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD----MESIP 841
            K T + RK +  PQ         SR +S   GL   EE  EE+  E   DD    M    
Sbjct: 940  KETVTERKATEPPQG-------LSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQR 992

Query: 842  AVTTWNTYLRYITVHKSLIFVLIWCLVIF---LAEVAASLVVLWLLGNTPLQDKGNSTHS 898
            A   W    +Y+    S   +L+  L++F   L  +    +  WL   T       +  +
Sbjct: 993  AEIPWRACAKYL----SSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTD-SALTLTPAA 1047

Query: 899  RNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQ 958
            RN S +   T   + Y   ++  +    + +     + +  T + V+K LH  +L+ ++ 
Sbjct: 1048 RNCSLSQECTLDQTVYAM-VFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIIL 1106

Query: 959  APMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVA 1018
            APM    T   G ILNRFS D   +D  +P T+    +  L+ + A+AV++ + P   VA
Sbjct: 1107 APMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVA 1166

Query: 1019 TVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLF 1078
             +P+ +    ++ YF   S+ L+QL+   + P+ +H   +++GL T+RAF  +  F+   
Sbjct: 1167 LLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKL 1226

Query: 1079 HKALNLHTANWFLYLSTLRWFQMRIEMI--FVIFFIAVTFISILTTGE-GEGRVGIILTL 1135
             +  + +        +  RW ++R+E I   V+   AVT IS     E   G VG+ LT 
Sbjct: 1227 LEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTY 1286

Query: 1136 AMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIEN 1195
            A+ + + L W V +  D++  + +V R+   +    E            G L+  +I +N
Sbjct: 1287 ALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESY---------EGLLAPSLIPKN 1337

Query: 1196 SHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLS 1255
                    WP  G++ +++L+ +Y      +L++++  I+PGQ++G+ GRTGSGKS+   
Sbjct: 1338 --------WPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSL 1389

Query: 1256 AFLRLLNT-EGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQE 1314
            AF R+++T EG I IDG+    + L   R    +I Q   +FSGT R NLDP  + SD  
Sbjct: 1390 AFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDST 1449

Query: 1315 IWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSA 1374
            +W+  +   L+ V++  PG LD ++ +GG   S G +QL CLAR+ + K  I ++DE +A
Sbjct: 1450 LWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATA 1509

Query: 1375 HLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNER 1434
             +D  T  I+++ +  AFAD TV+   HR+  +L     +V++   + ++D  +KLL+ +
Sbjct: 1510 SIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569



 Score =  197 bits (500), Expect = 8e-50
 Identities = 165/700 (23%), Positives = 317/700 (45%), Gaps = 80/700 (11%)

Query: 10  SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
           +++SK  + W    ++  +++ ++L  I ++P    ++ +   L E  + +  +++   +
Sbjct: 223 NLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQ 282

Query: 66  NPKLI-NALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDN----------- 113
             + I  AL   F  R +    F  L ++     PL +  I+     +N           
Sbjct: 283 GARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLG 342

Query: 114 ------KEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKL 167
                 +E  + A  L + L L  +++   L  + +     G+ +R A+ + IY K + L
Sbjct: 343 VYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHL 402

Query: 168 SSRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFC 225
           S+  L   +++ GQ+ +L++ + N+      L   +W  P+Q+ + + L++ +L  SA  
Sbjct: 403 STSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALI 462

Query: 226 GLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMI 285
           G   +I+LA  Q  +   + + +       +ERL  T+EM+  I+ +K Y WE      +
Sbjct: 463 GAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRV 522

Query: 286 ENLRQTELKLTRKAAY---VRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISF 342
           E  R+ E+   R  A    +  F ++A   +   + F+  + +           F ++S 
Sbjct: 523 ETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSL 582

Query: 343 CIVLRMAVTRQFPWA--VQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAF 400
             +L   VT  F  +  V++   +L ++ K+ +FL   E +  E      E   +   + 
Sbjct: 583 FHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIR--EEQCAPHEPTPQGPASK 637

Query: 401 WEEGFGELFEKAKQNNNNRKTSNGD-DSLF-----------------FSNFSLLGTPVLK 442
           ++     +  + +    + +   G   SL                  +  ++  G P L 
Sbjct: 638 YQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLS 697

Query: 443 DINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGK--------------------- 481
           +I  +I RGQL  + G  G GK+SLL+  +GE++   G                      
Sbjct: 698 NITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERET 757

Query: 482 -----IKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEK 536
                I+  G +++ SQ  W++  T++ENIIF   +++ RY+ VI+AC L+ DI      
Sbjct: 758 ATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHG 817

Query: 537 DNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMA 596
           D   +GE GI LSGGQR RIS+ARA+Y+ A++  LD PF  LD+     + ++ + +L+ 
Sbjct: 818 DQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLR 877

Query: 597 N--KTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQ 634
           +  +T +LVT K+++L  AD I+ + +G+    GT  + Q
Sbjct: 878 DDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQ 917



 Score = 72.8 bits (177), Expect = 2e-12
 Identities = 84/380 (22%), Positives = 159/380 (41%), Gaps = 47/380 (12%)

Query: 263  SEMIENIQSVKAYCWEEAME-KMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLS 321
            +E +E + +++A+ +E   + K++E      +      A  R+      +     V+  +
Sbjct: 1204 AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAA 1263

Query: 322  VLPYALIKGIILRKIFT-TISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQK 377
            V     I   + R++    +   +   + V+    W V+   D    LGA+ +I   L K
Sbjct: 1264 VTS---ISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLL-K 1319

Query: 378  QEYKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLL 436
             E ++ E  L    ++ +N    W ++G  ++     QN + R     D SL        
Sbjct: 1320 TEAESYE-GLLAPSLIPKN----WPDQGKIQI-----QNLSVRY----DSSL-------- 1357

Query: 437  GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG---------- 486
              PVLK +N  I  GQ + + G TG+GK+S  +     ++  EG I   G          
Sbjct: 1358 -KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHT 1416

Query: 487  ---RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGE 543
               R+S   Q   +  GTI+ N+       +      ++  QL+  +       + ++ E
Sbjct: 1417 LRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITE 1476

Query: 544  GGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILV 603
            GG   S GQR    LARA  +   ++++D     +D+ TE  I +  V    A++T + +
Sbjct: 1477 GGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATE-NILQKVVMTAFADRTVVTI 1535

Query: 604  TSKMEHLKKADKILILHEGS 623
              ++  +  AD +++L  G+
Sbjct: 1536 AHRVHTILSADLVIVLKRGA 1555



 Score = 55.5 bits (132), Expect = 4e-07
 Identities = 63/293 (21%), Positives = 124/293 (42%), Gaps = 43/293 (14%)

Query: 1219 YTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQ-IDG-VSWDS 1276
            +T  G   L NI+  I  GQ   ++G+ G GKS+LL A L      GE+Q + G V W S
Sbjct: 688  WTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAAL------GEMQKVSGAVFWSS 741

Query: 1277 ITLQQ------------------WRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKV 1318
            +   +                   R       QK ++ + T  +N+     ++ Q    V
Sbjct: 742  LPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMV 801

Query: 1319 ADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD- 1377
             +   L+  I+  P      + + G  LS G +Q + +AR++   A ++ LD+P + LD 
Sbjct: 802  IEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDI 861

Query: 1378 PVTYQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVRQ------------ 1423
             ++  +++  + +   D   TV+L  H+++ +      + +++  +++            
Sbjct: 862  HLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEC 921

Query: 1424 --YDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEE 1474
              ++  + L+N +    +  + ++R    P +  S+  S        EE EEE
Sbjct: 922  QLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEE 974


>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
          Length = 1359

 Score =  280 bits (716), Expect = 7e-75
 Identities = 181/600 (30%), Positives = 302/600 (50%), Gaps = 50/600 (8%)

Query: 845  TWNTYLRYITVHK----SLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQ--DKGNSTHS 898
            TW TY  YI        SL  V ++ L+I  A  +   + LWL   + +    +GN T  
Sbjct: 778  TWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMC 837

Query: 899  RNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQ 958
                   ++     +   ++Y      +L  G  +G     T +  S  LH  +   +L+
Sbjct: 838  E---VGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILK 894

Query: 959  APMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVA 1018
            +PMS  +T   G ++NRFSKD+  LD  LP    +F+Q   +V+  + ++A + P + + 
Sbjct: 895  SPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLV 954

Query: 1019 TVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLF 1078
               + V F +L   F +  Q+LK++E+  RSP FTH+ +S++GL  + A+G++       
Sbjct: 955  VASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKK------- 1007

Query: 1079 HKALNLHTANWFLYLS-TLRWFQMRIEMIF------VIFFIAVTFISILTTGEGEGRVGI 1131
               +  H     LY +  LRWF +R++++       V   + ++F SI T+ +G     +
Sbjct: 1008 ESCITYH----LLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKG-----L 1058

Query: 1132 ILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVM 1191
             L+  + +   LQ  V +  +  +   SV  + ++I         + T P K G   K  
Sbjct: 1059 SLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVP----ECTHPLKVGTCPKD- 1113

Query: 1192 IIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKS 1251
                        WPS G++T +D   +Y +    +L++++ +I  GQ VG++GRTGSGKS
Sbjct: 1114 ------------WPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKS 1161

Query: 1252 TLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQW 1310
            +L  A  RL+    G I ID V    ++L+  R    VIPQ   +F GT R NLDP+E  
Sbjct: 1162 SLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH 1221

Query: 1311 SDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLD 1370
            +D+ +W+V +   +R  I + P KL   + + G   S G +QL+C+AR++L  +KI+LLD
Sbjct: 1222 TDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLD 1281

Query: 1371 EPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKL 1430
            E +A +D  T  +++ T+K AF  CTV+   HR+  +L C   LV+E  KV ++D  + L
Sbjct: 1282 EATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVL 1341



 Score =  263 bits (672), Expect = 9e-70
 Identities = 169/655 (25%), Positives = 323/655 (49%), Gaps = 35/655 (5%)

Query: 4   SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
           +P++ A ++S   FSW  P++ KGYRQRL +  +  + + DS+D  +++    WD E+A 
Sbjct: 44  NPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVAR 103

Query: 64  KKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA-IY 122
               K   A      W+F    + + +      +    +G +I  +    + ER+   ++
Sbjct: 104 VGPEK---ASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVW 160

Query: 123 LGIGLCLLFIVR--TLLLHPAIFGL--HHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
           +GIGLC+       T +   A+     +   +++++A+ +L+++  +  S + L  IS+G
Sbjct: 161 VGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLV--SFKTLTHISVG 218

Query: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
           +++++LS++     E           P+ +       + +L  +A  G+   ++    Q 
Sbjct: 219 EVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQM 278

Query: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
            + ++   +R        +R+   +E +  I+ +K Y WE++    I+++R+ E KL  K
Sbjct: 279 FMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEK 338

Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQ----F 354
           A +V+  NS+         + L++  + L++    RK+   ++F ++    V +      
Sbjct: 339 AGFVQSGNSALAPIVSTIAIVLTLSCHILLR----RKLTAPVAFSVIAMFNVMKFSIAIL 394

Query: 355 PWAVQTWYDSLGAINKIQDFL---QKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEK 411
           P++++   ++  ++ +++  L       Y T   +  T  +++ N T  WE         
Sbjct: 395 PFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTV-LLLANATLTWEHEASRKSTP 453

Query: 412 AKQNNNNRKTSNGDDSLFFSNFSLLGT-------------PVLKDINFKIERGQLLAVAG 458
            K  N  R       S  +S  S                  VL  I+F + +G++L + G
Sbjct: 454 KKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICG 513

Query: 459 STGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYR 518
           + G+GK+SLL  ++G+++  +G +  +G +++ SQ +WI  G ++ENI+FG  YD  RY+
Sbjct: 514 NVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQ 573

Query: 519 SVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYL 578
             ++ C L++D+S     D   +GE G+ LSGGQR RISLARAVY D  LYLLD P   +
Sbjct: 574 HTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAV 633

Query: 579 DVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
           D    K +FE C+ K +  KT +LVT +++ L+  D++++L +G     GT  EL
Sbjct: 634 DAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKEL 688



 Score = 88.6 bits (218), Expect = 4e-17
 Identities = 61/255 (23%), Positives = 123/255 (48%), Gaps = 18/255 (7%)

Query: 1225 AILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDSITLQQWR 1283
            ++L +ISF +  G+ +G+ G  GSGKS+LL+A L  +  + G + ++G            
Sbjct: 494  SVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------ 541

Query: 1284 KAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
                 + Q+ +IF G  R+N+   E++  Q         GL+  +   P      + + G
Sbjct: 542  -TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600

Query: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADCTVILCEH 1402
              LS G +Q + LAR+V S  ++ LLD+P + +D  V   +    +K+     TV+L  H
Sbjct: 601  LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660

Query: 1403 RIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKP 1462
            +++ +  C + +++E+ ++ +  + ++L+ ER  + + I     ++    ++     +  
Sbjct: 661  QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLI---HNLRGLQFKDPEHLYNAA 717

Query: 1463 QIAALKEETEEEVQD 1477
             + A KE   E  +D
Sbjct: 718  MVEAFKESPAEREED 732



 Score = 67.4 bits (163), Expect = 1e-10
 Identities = 97/498 (19%), Positives = 200/498 (40%), Gaps = 80/498 (16%)

Query: 155  AMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLA------LAHFVWIAPLQV 208
            ++   ++ K LK      D    G+L++  S ++++ D  L       L  F  +  + V
Sbjct: 883  SLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILV 942

Query: 209  ALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIEN 268
             +L  +   +L   A   +GF I+L +F  G+  +       R+   +    ITS M + 
Sbjct: 943  -ILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTH---ITSSM-QG 997

Query: 269  IQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALI 328
            +  + AY  +E+                    ++ YFN +  +F+    V +++L + + 
Sbjct: 998  LGIIHAYGKKESCITY----------------HLLYFNCALRWFALRMDVLMNILTFTVA 1041

Query: 329  KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLT 388
                   +  T+SF  +   +      + +Q        ++ +     +   +T +   T
Sbjct: 1042 -------LLVTLSFSSISTSSKGLSLSYIIQ--------LSGLLQVCVRTGTET-QAKFT 1085

Query: 389  TTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLL---GTP-VLKDI 444
            + E++ E ++    E    L     +     K       + F ++ +     TP VL  +
Sbjct: 1086 SVELLREYISTCVPECTHPL-----KVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSL 1140

Query: 445  NFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKI-------------KHSGRISFC 491
            N  I+ GQ + + G TG+GK+SL M +   +EP+ G I                 +++  
Sbjct: 1141 NLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVI 1200

Query: 492  SQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGG 551
             Q   +  GT++ N+    S+ +     V++   + + I K  EK    + E G   S G
Sbjct: 1201 PQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVG 1260

Query: 552  QRARISLARAVYKDADLYLLDSPFGYLDVLTE-------KEIFESCVCKLMANKTRILVT 604
            +R  + +ARA+ +++ + LLD     +D  T+       K+ F+ C        T + + 
Sbjct: 1261 ERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGC--------TVLTIA 1312

Query: 605  SKMEHLKKADKILILHEG 622
             ++  +   D +L++  G
Sbjct: 1313 HRLNTVLNCDHVLVMENG 1330


>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
            [Homo sapiens]
          Length = 1545

 Score =  280 bits (715), Expect = 1e-74
 Identities = 161/519 (31%), Positives = 286/519 (55%), Gaps = 37/519 (7%)

Query: 918  IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFS 977
            I+V +A    A GF          +  S ILH ++L+++L+APM   +T   G I+NRF+
Sbjct: 1036 IFVFIAHFWSAFGF----------VHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFA 1085

Query: 978  KDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTS 1037
             DI+ +DD LP ++  +I   L +I  + ++ +  P   +  +P+ + ++ ++ +++ TS
Sbjct: 1086 GDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTS 1145

Query: 1038 QQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANW--FLYLST 1095
            +QL++L+S  RSPI++H   ++ GL  +RAF  Q  F  L H  + + T     F ++++
Sbjct: 1146 RQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRF--LKHNEVRIDTNQKCVFSWITS 1203

Query: 1096 LRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDV 1153
             RW  +R+E++    +FF A+  +    T  G+  VG +L+ A+NI  TL W V  + ++
Sbjct: 1204 NRWLAIRLELVGNLTVFFSALMMVIYRDTLSGD-TVGFVLSNALNITQTLNWLVRMTSEI 1262

Query: 1154 DSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVK 1213
            ++ + +V R+ ++  +  E       +P  +                   WPS G++   
Sbjct: 1263 ETNIVAVERITEYTKVENEAPWVTDKRPPPD-------------------WPSKGKIQFN 1303

Query: 1214 DLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEG-EIQIDGV 1272
            +   +Y    + +L  I+  I   +++G++GRTG+GKS+L +   R+L   G +I IDGV
Sbjct: 1304 NYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGV 1363

Query: 1273 SWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
               SI L   R+   +IPQ   +FSG+ R NLDP+  +SD+EIWK  +   L+S +    
Sbjct: 1364 DIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQ 1423

Query: 1333 GKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAF 1392
              L   + + G  LS G +QL+CL R++L K+KIL+LDE +A +D  T  +I+ T++  F
Sbjct: 1424 LGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEF 1483

Query: 1393 ADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLL 1431
            A CTVI   HR+  +++  + +V++  K+ +  S ++LL
Sbjct: 1484 AHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522



 Score =  243 bits (619), Expect = 1e-63
 Identities = 181/698 (25%), Positives = 311/698 (44%), Gaps = 88/698 (12%)

Query: 4   SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL-- 61
           +P   AS +S + +SW   I+ KGY++ L L D++++        L  K E    REL  
Sbjct: 193 NPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQK 252

Query: 62  ---------------------------------------ASKKNPK-----------LIN 71
                                                    KK  K           L+ 
Sbjct: 253 ARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMK 312

Query: 72  ALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLF 131
           AL + F+   +   +   + ++   V P LL +++ S+  D      I     I L    
Sbjct: 313 ALFKTFYMVLLKSFLLKLVNDIFTFVSPQLL-KLLISFASDRDTYLWIGYLCAILLFTAA 371

Query: 132 IVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKF 191
           ++++  L         +G+++R A+ + +YKK L LS+    + ++G+ V+L+S +  K 
Sbjct: 372 LIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKL 431

Query: 192 DEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQR 251
            +     H +W + LQ+ L +  +W  L  S   G+G ++++    A L       + + 
Sbjct: 432 MDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKN 491

Query: 252 AGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFF 311
                +RL I +E++  I+ +K + WE +    ++NLR+ ELK     + ++      F 
Sbjct: 492 MKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQ 551

Query: 312 FSGFFVVFLSVLPYALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAI 368
            +   V  ++   Y L+     +  +K FT+I+   +LR  ++   P  + +   +  + 
Sbjct: 552 LTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS-MLPMMISSMLQASVST 610

Query: 369 NKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSL 428
            +++ +L   +  T                          F+KA Q +    T   D   
Sbjct: 611 ERLEKYLGGDDLDTSAIRHDCN------------------FDKAMQFSEASFTWEHDSEA 652

Query: 429 FFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRI 488
                       ++D+N  I  GQL+AV G  G+GK+SL+  ++GE+E   G I   G  
Sbjct: 653 -----------TVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT 701

Query: 489 SFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITL 548
           ++  Q SWI  GTIK+NI+FG  ++E RY+ V++AC L  D+      D   +GE GI L
Sbjct: 702 AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINL 761

Query: 549 SGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSK 606
           SGGQ+ RISLARA Y++ D+YLLD P   +D    K IF   +    L+  KTR+LVT  
Sbjct: 762 SGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHS 821

Query: 607 MEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKL 644
           M  L + D+I++L  G+    G++S L   + +F+  L
Sbjct: 822 MHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNL 859



 Score = 76.6 bits (187), Expect = 2e-13
 Identities = 104/474 (21%), Positives = 194/474 (40%), Gaps = 42/474 (8%)

Query: 970  GGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIML 1029
            G  +N  S D   L D+       +  +L IV+    +   L P + +A V V+V  I +
Sbjct: 418  GETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSV-LAGVGVMVLVIPI 476

Query: 1030 RAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANW 1089
             A     S+ ++    + +      +   L G+  L+ F  +P F             N 
Sbjct: 477  NAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKN- 535

Query: 1090 FLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNS 1149
                  L + Q++  +IFV F +    +S++T          +L  + NI+   +    +
Sbjct: 536  -----LLAFSQLQCVVIFV-FQLTPVLVSVVTFSV------YVLVDSNNILDAQK--AFT 581

Query: 1150 SIDVDSLMRSVSRVFKFI--DMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSG 1207
            SI + +++R    +   +   M      T+  + Y  G       ++ S ++ D  +   
Sbjct: 582  SITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGD-----DLDTSAIRHDCNFDKA 636

Query: 1208 GQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGE 1266
             Q +    T  +     A + +++  I  GQ V ++G  GSGKS+L+SA L  + N  G 
Sbjct: 637  MQFSEASFT--WEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGH 694

Query: 1267 IQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRS 1326
            I I G +               +PQ+ +I +GT + N+    +++++   +V +   L  
Sbjct: 695  ITIKGTT-------------AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLP 741

Query: 1327 VIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIR 1385
             +E  PG     + + G  LS G KQ + LAR+      I LLD+P + +D  V   I  
Sbjct: 742  DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801

Query: 1386 RTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
            + L         T +L  H +  + +  + +V+    + +  S   LL ++  F
Sbjct: 802  KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855



 Score = 60.1 bits (144), Expect = 2e-08
 Identities = 101/554 (18%), Positives = 210/554 (37%), Gaps = 65/554 (11%)

Query: 111  PDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSR 170
            P ++ +  + +Y  +GL     V       A FG  H    +   + + I    L+   R
Sbjct: 1016 PASQRDMRVGVYGALGLAQGIFVFIAHFWSA-FGFVHASNILHKQLLNNI----LRAPMR 1070

Query: 171  VLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFC----G 226
              D    G++V+  + +++  D+ L  +   WI    + ++  L+   +    F      
Sbjct: 1071 FFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCF-LGIISTLVMICMATPVFTIIVIP 1129

Query: 227  LGFLIV-LALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMI 285
            LG + V + +F     R + +        I       SE +  +  ++A+  ++   K  
Sbjct: 1130 LGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHF---SETVSGLPVIRAFEHQQRFLKHN 1186

Query: 286  ENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIV 345
            E    T  K          + +      G   VF S L   + +  +      T+ F + 
Sbjct: 1187 EVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGD---TVGFVLS 1243

Query: 346  LRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGF 405
              + +T+   W V+   +                   +E N+   E + E         +
Sbjct: 1244 NALNITQTLNWLVRMTSE-------------------IETNIVAVERITE---------Y 1275

Query: 406  GELFEKAKQNNNNRKTSN--GDDSLFFSNFSLLGTP----VLKDINFKIERGQLLAVAGS 459
             ++  +A    + R   +      + F+N+ +   P    VL+ I   I   + + V G 
Sbjct: 1276 TKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGR 1335

Query: 460  TGAGKTSLLMVIMGELEPSEGKIKHSG-------------RISFCSQFSWIMPGTIKENI 506
            TGAGK+SL   +   LE + G+I   G             +++   Q   +  G+++ N+
Sbjct: 1336 TGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNL 1395

Query: 507  IFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDA 566
                +Y +      ++   L+  ++      +  + E G  LS GQR  + L RA+ + +
Sbjct: 1396 DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKS 1455

Query: 567  DLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYF 626
             + +LD     +D+ T+  + ++ +    A+ T I +  ++  +  +DK+++L  G    
Sbjct: 1456 KILVLDEATAAVDLETD-NLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIE 1514

Query: 627  YGTFSELQNLQPDF 640
             G+  EL  +   F
Sbjct: 1515 CGSPEELLQIPGPF 1528


>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
            [Homo sapiens]
          Length = 1382

 Score =  279 bits (714), Expect = 1e-74
 Identities = 187/658 (28%), Positives = 322/658 (48%), Gaps = 44/658 (6%)

Query: 781  QNIHRKTTAS----TRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836
            Q +H++ T+     T K++  P+             SQ     + E +N   + E     
Sbjct: 731  QKMHKEATSDMLQDTAKIAEKPKVE-----------SQALATSLEESLNGNAVPEHQLTQ 779

Query: 837  MESIPAVT-TWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVL--WLLGNTPLQDKG 893
             E +   + +W  Y  YI         ++ C++ F   +   L +   W L     Q  G
Sbjct: 780  EEEMEEGSLSWRVYHHYIQAAGGY---MVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSG 836

Query: 894  -NSTHSRNNSYAVI--ITSTSSYYVFYIYVGV-ADTLLAMGFFRGLPLVHTLITVSKILH 949
             NS+   N + A +  I        + +  G+ A  L+ +G              S  LH
Sbjct: 837  TNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALH 896

Query: 950  HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
            +K+ + V + PMS  +T+  G +LN F+ D+  LD LLP+    F+ L L+VI  + +V+
Sbjct: 897  NKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVS 956

Query: 1010 VLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFG 1069
            VL PYI +    ++V   +    F +     K+LE+  RSP+F+H++ SL+GL ++  +G
Sbjct: 957  VLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYG 1016

Query: 1070 RQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT-FISILTTGEGEGR 1128
            +   F + F +  +       L+LS+ RW  +R+E++  +  +AV  F++   +      
Sbjct: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076

Query: 1129 VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLS 1188
              + + + + + S+ Q      ++ ++   +V R+ +++ M     P             
Sbjct: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP------------- 1123

Query: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGS 1248
              + +E +   +   WP  G++  +D   KY +    +L  I+ +I   + VG++GRTGS
Sbjct: 1124 --LHMEGTSCPQG--WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179

Query: 1249 GKSTLLSAFLRLLNT-EGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPY 1307
            GKS+L  A  RL+    G I IDGV   SI L+  R    VIPQ   + SGT R NLDP+
Sbjct: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239

Query: 1308 EQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367
            ++ +DQ+IW   +   L   I +FP KL   +V+ G   S G +QL+C+AR+VL  +KI+
Sbjct: 1240 DRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKII 1299

Query: 1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYD 1425
            L+DE +A +D  T  +I+RT+++AF  CTV++  HR+  +L C   LV+   KV ++D
Sbjct: 1300 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1357



 Score =  250 bits (639), Expect = 6e-66
 Identities = 180/642 (28%), Positives = 314/642 (48%), Gaps = 20/642 (3%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
           PL+ A + S L  SW  P++ +  R RL+ + I  +   D++D   ++L R W+ E++ +
Sbjct: 85  PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRR 144

Query: 65  --KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIY 122
             +   ++  + R    R +F  +      +   + P+L+   I  Y     EE+   + 
Sbjct: 145 GIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS----EEQLGNVV 200

Query: 123 LGIGLCL-LFI---VRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
            G+GLC  LF+   V++L    +        ++ R A+ S  ++K ++  S +   I+ G
Sbjct: 201 HGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVI--HITSG 258

Query: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
           + +S  + ++N   EG+     V I    + +     + ++  +AF  +   +++     
Sbjct: 259 EAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAV 318

Query: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
            + RM +K +   +    +R+ +TSE++  I+ +K Y WE+   K+IE+LR+ E KL  K
Sbjct: 319 FMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEK 378

Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK-GIILRKIFTTISFCIVLRMAVTRQFPWA 357
              V+   S   F        + VL +  +K  +     F+ ++   +LR++V    P A
Sbjct: 379 CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF-VPIA 437

Query: 358 VQTWYDSLGAINKIQDFLQKQEYKTLEYNLT--TTEVVMENVTAFWEEGFGELFEKAKQN 415
           V+   +S  A+ + + F  ++        L   +  +V E  T  W++    +   A + 
Sbjct: 438 VKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALEL 497

Query: 416 NNNRKTSNG----DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471
             N   S G     D+L          P L  IN  + +G +L V G+TG+GK+SLL  I
Sbjct: 498 ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557

Query: 472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDIS 531
           + E+   EG +   G +++  Q +WI+ G I+ENI+ G +YD+ RY  V+  C L  D+ 
Sbjct: 558 LEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617

Query: 532 KFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV 591
                D   +GE G+ LSGGQ+ RISLARAVY D  +YLLD P   +D    K IFE C+
Sbjct: 618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI 677

Query: 592 CKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
            K +  KT +LVT ++++L+   +I++L  G     GT SEL
Sbjct: 678 KKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSEL 719



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 21/263 (7%)

Query: 1221 EGGNAI---LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDS 1276
            E GN++   L  I+  +S G  +G+ G TGSGKS+LLSA L  ++  EG + + G     
Sbjct: 518  EEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG----- 572

Query: 1277 ITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLD 1336
                    +   +PQ+ +I SG  R+N+     +      +V     L   +E  P    
Sbjct: 573  --------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM 624

Query: 1337 FVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADC 1395
              + + G  LS G KQ + LAR+V S  +I LLD+P + +D  V   I    +K+     
Sbjct: 625  TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684

Query: 1396 TVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH-RN 1454
            TV+L  H+++ +  C Q +++E  K+ +  +  +L+ ++  + Q I    +       ++
Sbjct: 685  TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744

Query: 1455 SSKCKSKPQI--AALKEETEEEV 1475
            ++K   KP++   AL    EE +
Sbjct: 745  TAKIAEKPKVESQALATSLEESL 767



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 51/203 (25%), Positives = 96/203 (47%), Gaps = 28/203 (13%)

Query: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
            VL  IN  I   +++ + G TG+GK+SL M +   +EP  G+I   G             
Sbjct: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRS 1216

Query: 487  RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
            ++S   Q   ++ GTI+ N+     + + +    ++   L + ISKF +K +  + E G 
Sbjct: 1217 KLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGG 1276

Query: 547  TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTE-------KEIFESCVCKLMANKT 599
              S G+R  + +ARAV +++ + L+D     +D+ T+       +E F+ C        T
Sbjct: 1277 NFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGC--------T 1328

Query: 600  RILVTSKMEHLKKADKILILHEG 622
             +++  ++  +   D IL++  G
Sbjct: 1329 VLVIAHRVTTVLNCDHILVMGNG 1351


>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
            [Homo sapiens]
          Length = 1382

 Score =  279 bits (714), Expect = 1e-74
 Identities = 187/658 (28%), Positives = 322/658 (48%), Gaps = 44/658 (6%)

Query: 781  QNIHRKTTAS----TRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836
            Q +H++ T+     T K++  P+             SQ     + E +N   + E     
Sbjct: 731  QKMHKEATSDMLQDTAKIAEKPKVE-----------SQALATSLEESLNGNAVPEHQLTQ 779

Query: 837  MESIPAVT-TWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVL--WLLGNTPLQDKG 893
             E +   + +W  Y  YI         ++ C++ F   +   L +   W L     Q  G
Sbjct: 780  EEEMEEGSLSWRVYHHYIQAAGGY---MVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSG 836

Query: 894  -NSTHSRNNSYAVI--ITSTSSYYVFYIYVGV-ADTLLAMGFFRGLPLVHTLITVSKILH 949
             NS+   N + A +  I        + +  G+ A  L+ +G              S  LH
Sbjct: 837  TNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALH 896

Query: 950  HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
            +K+ + V + PMS  +T+  G +LN F+ D+  LD LLP+    F+ L L+VI  + +V+
Sbjct: 897  NKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVS 956

Query: 1010 VLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFG 1069
            VL PYI +    ++V   +    F +     K+LE+  RSP+F+H++ SL+GL ++  +G
Sbjct: 957  VLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYG 1016

Query: 1070 RQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT-FISILTTGEGEGR 1128
            +   F + F +  +       L+LS+ RW  +R+E++  +  +AV  F++   +      
Sbjct: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076

Query: 1129 VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLS 1188
              + + + + + S+ Q      ++ ++   +V R+ +++ M     P             
Sbjct: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP------------- 1123

Query: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGS 1248
              + +E +   +   WP  G++  +D   KY +    +L  I+ +I   + VG++GRTGS
Sbjct: 1124 --LHMEGTSCPQG--WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179

Query: 1249 GKSTLLSAFLRLLNT-EGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPY 1307
            GKS+L  A  RL+    G I IDGV   SI L+  R    VIPQ   + SGT R NLDP+
Sbjct: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239

Query: 1308 EQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367
            ++ +DQ+IW   +   L   I +FP KL   +V+ G   S G +QL+C+AR+VL  +KI+
Sbjct: 1240 DRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKII 1299

Query: 1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYD 1425
            L+DE +A +D  T  +I+RT+++AF  CTV++  HR+  +L C   LV+   KV ++D
Sbjct: 1300 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1357



 Score =  250 bits (639), Expect = 6e-66
 Identities = 180/642 (28%), Positives = 314/642 (48%), Gaps = 20/642 (3%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
           PL+ A + S L  SW  P++ +  R RL+ + I  +   D++D   ++L R W+ E++ +
Sbjct: 85  PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRR 144

Query: 65  --KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIY 122
             +   ++  + R    R +F  +      +   + P+L+   I  Y     EE+   + 
Sbjct: 145 GIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS----EEQLGNVV 200

Query: 123 LGIGLCL-LFI---VRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
            G+GLC  LF+   V++L    +        ++ R A+ S  ++K ++  S +   I+ G
Sbjct: 201 HGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVI--HITSG 258

Query: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
           + +S  + ++N   EG+     V I    + +     + ++  +AF  +   +++     
Sbjct: 259 EAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAV 318

Query: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
            + RM +K +   +    +R+ +TSE++  I+ +K Y WE+   K+IE+LR+ E KL  K
Sbjct: 319 FMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEK 378

Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK-GIILRKIFTTISFCIVLRMAVTRQFPWA 357
              V+   S   F        + VL +  +K  +     F+ ++   +LR++V    P A
Sbjct: 379 CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF-VPIA 437

Query: 358 VQTWYDSLGAINKIQDFLQKQEYKTLEYNLT--TTEVVMENVTAFWEEGFGELFEKAKQN 415
           V+   +S  A+ + + F  ++        L   +  +V E  T  W++    +   A + 
Sbjct: 438 VKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALEL 497

Query: 416 NNNRKTSNG----DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471
             N   S G     D+L          P L  IN  + +G +L V G+TG+GK+SLL  I
Sbjct: 498 ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557

Query: 472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDIS 531
           + E+   EG +   G +++  Q +WI+ G I+ENI+ G +YD+ RY  V+  C L  D+ 
Sbjct: 558 LEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617

Query: 532 KFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV 591
                D   +GE G+ LSGGQ+ RISLARAVY D  +YLLD P   +D    K IFE C+
Sbjct: 618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI 677

Query: 592 CKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
            K +  KT +LVT ++++L+   +I++L  G     GT SEL
Sbjct: 678 KKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSEL 719



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 21/263 (7%)

Query: 1221 EGGNAI---LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDS 1276
            E GN++   L  I+  +S G  +G+ G TGSGKS+LLSA L  ++  EG + + G     
Sbjct: 518  EEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG----- 572

Query: 1277 ITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLD 1336
                    +   +PQ+ +I SG  R+N+     +      +V     L   +E  P    
Sbjct: 573  --------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM 624

Query: 1337 FVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADC 1395
              + + G  LS G KQ + LAR+V S  +I LLD+P + +D  V   I    +K+     
Sbjct: 625  TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684

Query: 1396 TVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH-RN 1454
            TV+L  H+++ +  C Q +++E  K+ +  +  +L+ ++  + Q I    +       ++
Sbjct: 685  TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744

Query: 1455 SSKCKSKPQI--AALKEETEEEV 1475
            ++K   KP++   AL    EE +
Sbjct: 745  TAKIAEKPKVESQALATSLEESL 767



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 51/203 (25%), Positives = 96/203 (47%), Gaps = 28/203 (13%)

Query: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
            VL  IN  I   +++ + G TG+GK+SL M +   +EP  G+I   G             
Sbjct: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRS 1216

Query: 487  RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
            ++S   Q   ++ GTI+ N+     + + +    ++   L + ISKF +K +  + E G 
Sbjct: 1217 KLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGG 1276

Query: 547  TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTE-------KEIFESCVCKLMANKT 599
              S G+R  + +ARAV +++ + L+D     +D+ T+       +E F+ C        T
Sbjct: 1277 NFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGC--------T 1328

Query: 600  RILVTSKMEHLKKADKILILHEG 622
             +++  ++  +   D IL++  G
Sbjct: 1329 VLVIAHRVTTVLNCDHILVMGNG 1351


>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
            [Homo sapiens]
          Length = 1527

 Score =  279 bits (713), Expect = 2e-74
 Identities = 159/532 (29%), Positives = 287/532 (53%), Gaps = 24/532 (4%)

Query: 909  STSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
            +TS     Y  +G+    L M     + +    I  +++LH  +LH+ +++P S  +T  
Sbjct: 1007 NTSLRLGVYAALGILQGFLVM--LAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTP 1064

Query: 969  AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
            +G ILN FSKDI ++D++L   I   +      I  + V+    P   V  +P+ V + +
Sbjct: 1065 SGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTL 1124

Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
            ++ ++  TS+QLK+LES  RSPI++H   ++ G   +RA+ R   FE +    ++ +  +
Sbjct: 1125 VQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRS 1184

Query: 1089 WFLYLSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWA 1146
             + Y+ + RW  + +E +   V+ F A+ F  I  +    G VG+ ++ ++ +   L W 
Sbjct: 1185 CYPYIISNRWLSIGVEFVGNCVVLFAAL-FAVIGRSSLNPGLVGLSVSYSLQVTFALNWM 1243

Query: 1147 VNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPS 1206
            +    D++S + +V RV                K Y   +     ++E S  +  + WP 
Sbjct: 1244 IRMMSDLESNIVAVERV----------------KEYSKTETEAPWVVEGS--RPPEGWPP 1285

Query: 1207 GGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
             G++  ++ + +Y  G + +L ++S  +  G++VG++GRTG+GKS++     R+L   +G
Sbjct: 1286 RGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1345

Query: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLR 1325
            EI+IDG++   I L   R    +IPQ   +FSGT R NLDP+  +S+++IW   +   L 
Sbjct: 1346 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLH 1405

Query: 1326 SVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIR 1385
            + +   P  LDF   +GG  LS G +QL+CLAR++L K++IL+LDE +A +D  T  +I+
Sbjct: 1406 TFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQ 1465

Query: 1386 RTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
             T++  F  CTV+   HR+  +++  + LV+++  V ++DS   L+  R +F
Sbjct: 1466 ATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517



 Score =  261 bits (667), Expect = 4e-69
 Identities = 178/677 (26%), Positives = 314/677 (46%), Gaps = 72/677 (10%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE---- 60
           P   A  +S+LFF W   +   GYR  LE  D++ +   D +  + ++L   W ++    
Sbjct: 208 PETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQT 267

Query: 61  ------LASKKN-----------------PKLINALRRCFFWRFMFYGIFLYLGEVTKAV 97
                  A  KN                 P  + AL   F   F+    F  + ++   +
Sbjct: 268 ARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFI 327

Query: 98  QPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLF-IVRTLLLHPAIFGLHHIGMQMRIAM 156
            P LL  +I      N    S   +L  GL  L  ++++L+L      +   G++ R  +
Sbjct: 328 NPQLLSILIRFIS--NPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGI 385

Query: 157 FSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIW 216
             +IY+K L +++ V    ++G++V+L+S +  +F +     + +W APLQ+ L +  +W
Sbjct: 386 MGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLW 445

Query: 217 ELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYC 276
           + L  S   G+ F+++L      +   M  ++ ++      R+ + SE++  I+ +K Y 
Sbjct: 446 QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYA 505

Query: 277 WEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKG---IIL 333
           WE +  K +E +RQ EL+L R AAY+    +  +  S F V  +++  Y  +     +  
Sbjct: 506 WEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDA 565

Query: 334 RKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTE-- 391
            K F ++S   +LR+ +    P  +     +  ++ +IQ FL ++E         T    
Sbjct: 566 EKAFVSVSLFNILRLPLN-MLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPG 624

Query: 392 --VVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIE 449
             + + + T  W +                                   P L  ++ ++ 
Sbjct: 625 YAITIHSGTFTWAQDL--------------------------------PPTLHSLDIQVP 652

Query: 450 RGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFG 509
           +G L+AV G  G GK+SL+  ++GE+E  EGK+   G +++  Q +WI   T++EN++FG
Sbjct: 653 KGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFG 712

Query: 510 VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLY 569
            + +  RY+  ++AC L  D+      D   +GE GI LSGGQR R+SLARAVY DAD++
Sbjct: 713 KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIF 772

Query: 570 LLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKKADKILILHEGSSYFY 627
           LLD P   +D    K IF+  +    ++A KTR+LVT  +  L + D I++L +G     
Sbjct: 773 LLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEM 832

Query: 628 GTFSELQNLQPDFSSKL 644
           G +  L      F++ L
Sbjct: 833 GPYPALLQRNGSFANFL 849



 Score = 71.6 bits (174), Expect = 5e-12
 Identities = 112/539 (20%), Positives = 210/539 (38%), Gaps = 91/539 (16%)

Query: 113  NKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVL 172
            N     + +Y  +G+   F+V    +  A  G+       R+   +L++ K ++      
Sbjct: 1006 NNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQ----AARVLHQALLHNK-IRSPQSFF 1060

Query: 173  DKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALL---MGLIWELLQASAFCGLGF 229
            D    G++++  S ++   DE LA        P+ + LL      I  L+   A   L  
Sbjct: 1061 DTTPSGRILNCFSKDIYVVDEVLA--------PVILMLLNSFFNAISTLVVIMASTPLFT 1112

Query: 230  LIVLAL---------FQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEA 280
            +++L L         F A   R + +        I       SE +     ++AY     
Sbjct: 1113 VVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHF---SETVTGASVIRAY----N 1165

Query: 281  MEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTT- 339
              +  E +  T++   +++ Y  Y  S+ +   G   V   V+ +A +  +I R      
Sbjct: 1166 RSRDFEIISDTKVDANQRSCYP-YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPG 1224

Query: 340  -ISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVT 398
             +   +   + VT    W ++   D    I  ++        +  EY+ T TE       
Sbjct: 1225 LVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVE--------RVKEYSKTETEAPWVVEG 1276

Query: 399  AFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTP----VLKDINFKIERGQLL 454
            +   EG+    E                 + F N+S+   P    VL+D++  +  G+ +
Sbjct: 1277 SRPPEGWPPRGE-----------------VEFRNYSVRYRPGLDLVLRDLSLHVHGGEKV 1319

Query: 455  AVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-------------RISFCSQFSWIMPGT 501
             + G TGAGK+S+ + +   LE ++G+I+  G             +++   Q   +  GT
Sbjct: 1320 GIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGT 1379

Query: 502  IKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARA 561
            ++ N+    SY E      ++   L   +S      +    EGG  LS GQR  + LARA
Sbjct: 1380 LRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARA 1439

Query: 562  VYKDADLYLLDSPFGYLDVLTEKEI-------FESCVCKLMANK-------TRILVTSK 606
            + + + + +LD     +D+ T+  I       F++C    +A++       TR+LV  K
Sbjct: 1440 LLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDK 1498



 Score = 65.1 bits (157), Expect = 5e-10
 Identities = 73/302 (24%), Positives = 134/302 (44%), Gaps = 28/302 (9%)

Query: 1148 NSSIDVDSLMRSVSRVFKFIDMPTEGKP------TKSTKPYKNGQ--LSKVMIIENSHVK 1199
            N+ +D +    SVS +F  + +P    P      T+++   K  Q  LS+  +   S V+
Sbjct: 560  NNVLDAEKAFVSVS-LFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS-VE 617

Query: 1200 KDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL- 1258
            +  I P G  +T+   T  + +     L ++   +  G  V ++G  G GKS+L+SA L 
Sbjct: 618  RKTISP-GYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676

Query: 1259 RLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKV 1318
             +   EG++ + G             +   +PQ+ +I + T ++N+   +  + +   + 
Sbjct: 677  EMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQT 723

Query: 1319 ADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP 1378
             +   L + +E  PG     + + G  LS G +Q + LAR+V S A I LLD+P + +D 
Sbjct: 724  LEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDS 783

Query: 1379 -VTYQIIRRTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
             V   I    +  +   A  T +L  H I  + +    +V+ + +V +      LL    
Sbjct: 784  HVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNG 843

Query: 1436 LF 1437
             F
Sbjct: 844  SF 845


>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
            [Homo sapiens]
          Length = 1475

 Score =  276 bits (706), Expect = 1e-73
 Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)

Query: 917  YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
            Y  +G++  +   G+   + +   L   S+ LH  +LHS+L++PMS      +G ++NRF
Sbjct: 963  YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1020

Query: 977  SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
            SK++  +D ++P  I  F+  L  VIGA  V+ +  P   +   P+ + +  ++ +++ +
Sbjct: 1021 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1080

Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
            S+QLK+LES  RSP+++H   +L G+  +RAF  Q  F       ++ +   ++  +   
Sbjct: 1081 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1140

Query: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
            RW  +R+E +   I   A  F  I       G VG+ ++ ++ + + L W V  S ++++
Sbjct: 1141 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1200

Query: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
             + +V R+ ++ +   E     + T P  +                   WP  G++  ++
Sbjct: 1201 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1241

Query: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
               +Y E  + +L +I+ +I+ G++VG++GRTG+GKS+L     R+  + EGEI IDG++
Sbjct: 1242 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1301

Query: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
               I L   R    +IPQ   +FSG+ R NLDP+ Q+SD+E+W   +   L+  +   P 
Sbjct: 1302 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1361

Query: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
            KLD    +GG  LS G +QL+CLAR++L K KIL+LDE +A +D  T  +I+ T++  F 
Sbjct: 1362 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1421

Query: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
            DCTV+   HR+  +++  + +V+++ ++++Y +   LL +R LF
Sbjct: 1422 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1465



 Score =  184 bits (468), Expect = 4e-46
 Identities = 153/707 (21%), Positives = 281/707 (39%), Gaps = 138/707 (19%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
           P   AS +S++ F W   ++ +GYRQ LE SD++ +   D+++ +   L + W +E A  
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268

Query: 65  K----------------------------------------NPKLINALRRCFFWRFMFY 84
           +                                        NP L   L + F   F+  
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328

Query: 85  GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
             F  + ++     P +L +++  +  D K       +  + L +   ++TL+LH     
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387

Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
               GM+++ A+   +Y+K L +++      ++G++V+L+S +  +F +     + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447

Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
           PLQV L + L+W  L  S   G+  ++++    A +      Y+         R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507

Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
           ++  I+ +K Y WE A +  +  +RQ ELK+ +K+AY+    +  +  + F V   +   
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567

Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
           Y  I     +  +  F +++   +LR  +    P  + +   +  ++ +++ FL  +E  
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELE 626

Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
                 + ++    T  + + N T  W                                 
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656

Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
               P L  I F I  G L+AV G  G GK+SLL  ++ E++  EG +   G +++  Q 
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQ 714

Query: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
           +WI   +++ENI+FG   +E  YRSVI+AC L  D+                 L  G R 
Sbjct: 715 AWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLE---------------ILPSGDRT 759

Query: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKAD 614
            I                                         KTRILVT  M +L + D
Sbjct: 760 EIG---------------------------------------EKTRILVTHSMSYLPQVD 780

Query: 615 KILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
            I+++  G     G++ EL      F+  L    S +Q      N +
Sbjct: 781 VIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 827



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)

Query: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
            VL+ IN  I  G+ + + G TGAGK+SL + +    E +EG+I   G             
Sbjct: 1253 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1312

Query: 487  RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
            +I+   Q   +  G+++ N+     Y +    + ++   L++ +S   +K +    EGG 
Sbjct: 1313 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1372

Query: 547  TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
             LS GQR  + LARA+ +   + +LD     +D+ T+ ++ +S +     + T + +  +
Sbjct: 1373 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1431

Query: 607  MEHLKKADKILILHEGSSYFYGTFSEL 633
            +  +    ++++L +G    YG  S+L
Sbjct: 1432 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1458



 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 32/115 (27%), Positives = 57/115 (49%), Gaps = 16/115 (13%)

Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
            +E   +++  +   GG   +TV++ T  +       L  I+FSI  G  V ++G+ G GK
Sbjct: 625  LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684

Query: 1251 STLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNL 1304
            S+LLSA L  ++  EG + I G             +   +PQ+ +I + + R+N+
Sbjct: 685  SSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENI 726


>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
            [Homo sapiens]
          Length = 1416

 Score =  276 bits (706), Expect = 1e-73
 Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)

Query: 917  YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
            Y  +G++  +   G+   + +   L   S+ LH  +LHS+L++PMS      +G ++NRF
Sbjct: 904  YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 961

Query: 977  SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
            SK++  +D ++P  I  F+  L  VIGA  V+ +  P   +   P+ + +  ++ +++ +
Sbjct: 962  SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1021

Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
            S+QLK+LES  RSP+++H   +L G+  +RAF  Q  F       ++ +   ++  +   
Sbjct: 1022 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1081

Query: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
            RW  +R+E +   I   A  F  I       G VG+ ++ ++ + + L W V  S ++++
Sbjct: 1082 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1141

Query: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
             + +V R+ ++ +   E     + T P  +                   WP  G++  ++
Sbjct: 1142 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1182

Query: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
               +Y E  + +L +I+ +I+ G++VG++GRTG+GKS+L     R+  + EGEI IDG++
Sbjct: 1183 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1242

Query: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
               I L   R    +IPQ   +FSG+ R NLDP+ Q+SD+E+W   +   L+  +   P 
Sbjct: 1243 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1302

Query: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
            KLD    +GG  LS G +QL+CLAR++L K KIL+LDE +A +D  T  +I+ T++  F 
Sbjct: 1303 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1362

Query: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
            DCTV+   HR+  +++  + +V+++ ++++Y +   LL +R LF
Sbjct: 1363 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1406



 Score =  142 bits (359), Expect = 2e-33
 Identities = 113/543 (20%), Positives = 222/543 (40%), Gaps = 84/543 (15%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
           P   AS +S++ F W   ++ +GYRQ LE SD++ +   D+++ +   L + W +E A  
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268

Query: 65  K----------------------------------------NPKLINALRRCFFWRFMFY 84
           +                                        NP L   L + F   F+  
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328

Query: 85  GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
             F  + ++     P +L +++  +  D K       +  + L +   ++TL+LH     
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387

Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
               GM+++ A+   +Y+K L +++      ++G++V+L+S +  +F +     + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447

Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
           PLQV L + L+W  L  S   G+  ++++    A +      Y+         R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507

Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
           ++  I+ +K Y WE A +  +  +RQ ELK+ +K+AY+    +  +  + F V   +   
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567

Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
           Y  I     +  +  F +++   +LR  +    P  + +   +  ++ +++ FL  +E  
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPL-NILPMVISSIVQASVSLKRLRIFLSHEELE 626

Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
                 + ++    T  + + N T  W                                 
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656

Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
               P L  I F I  G L+AV G  G GK+SLL  ++ E++  EG +    RI      
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSM 714

Query: 495 SWI 497
           S++
Sbjct: 715 SYL 717



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)

Query: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
            VL+ IN  I  G+ + + G TGAGK+SL + +    E +EG+I   G             
Sbjct: 1194 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1253

Query: 487  RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
            +I+   Q   +  G+++ N+     Y +    + ++   L++ +S   +K +    EGG 
Sbjct: 1254 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1313

Query: 547  TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
             LS GQR  + LARA+ +   + +LD     +D+ T+ ++ +S +     + T + +  +
Sbjct: 1314 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1372

Query: 607  MEHLKKADKILILHEGSSYFYGTFSEL 633
            +  +    ++++L +G    YG  S+L
Sbjct: 1373 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1399



 Score = 42.4 bits (98), Expect = 0.003
 Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 3/80 (3%)

Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
            +E   +++  +   GG   +TV++ T  +       L  I+FSI  G  V ++G+ G GK
Sbjct: 625  LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684

Query: 1251 STLLSAFLRLLN-TEGEIQI 1269
            S+LLSA L  ++  EG + I
Sbjct: 685  SSLLSALLAEMDKVEGHVAI 704



 Score = 33.9 bits (76), Expect = 1.2
 Identities = 21/67 (31%), Positives = 32/67 (47%)

Query: 595 MANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFS 654
           +A KTRILVT  M +L + D I+++  G     G++ EL      F+  L    S +Q  
Sbjct: 702 VAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQ 761

Query: 655 AERRNSI 661
               N +
Sbjct: 762 DAEENGV 768


>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
            [Homo sapiens]
          Length = 1472

 Score =  276 bits (706), Expect = 1e-73
 Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)

Query: 917  YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
            Y  +G++  +   G+   + +   L   S+ LH  +LHS+L++PMS      +G ++NRF
Sbjct: 960  YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1017

Query: 977  SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
            SK++  +D ++P  I  F+  L  VIGA  V+ +  P   +   P+ + +  ++ +++ +
Sbjct: 1018 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1077

Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
            S+QLK+LES  RSP+++H   +L G+  +RAF  Q  F       ++ +   ++  +   
Sbjct: 1078 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1137

Query: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
            RW  +R+E +   I   A  F  I       G VG+ ++ ++ + + L W V  S ++++
Sbjct: 1138 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1197

Query: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
             + +V R+ ++ +   E     + T P  +                   WP  G++  ++
Sbjct: 1198 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1238

Query: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
               +Y E  + +L +I+ +I+ G++VG++GRTG+GKS+L     R+  + EGEI IDG++
Sbjct: 1239 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1298

Query: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
               I L   R    +IPQ   +FSG+ R NLDP+ Q+SD+E+W   +   L+  +   P 
Sbjct: 1299 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1358

Query: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
            KLD    +GG  LS G +QL+CLAR++L K KIL+LDE +A +D  T  +I+ T++  F 
Sbjct: 1359 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1418

Query: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
            DCTV+   HR+  +++  + +V+++ ++++Y +   LL +R LF
Sbjct: 1419 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1462



 Score =  150 bits (380), Expect = 7e-36
 Identities = 146/709 (20%), Positives = 274/709 (38%), Gaps = 145/709 (20%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
           P   AS +S++ F W   ++ +GYRQ LE SD++ +   D+++ +   L + W +E A  
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268

Query: 65  K----------------------------------------NPKLINALRRCFFWRFMFY 84
           +                                        NP L   L + F   F+  
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328

Query: 85  GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
             F  + ++     P +L +++  +  D K       +  + L +   ++TL+LH     
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387

Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
               GM+++ A+   +Y+K L +++      ++G++V+L+S +  +F +     + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447

Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
           PLQV L + L+W  L  S   G+  ++++    A +      Y+         R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507

Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
           ++  I+ +K Y WE A +  +  +RQ ELK+ +K+AY+    +  +  + F V   +   
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567

Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
           Y  I     +  +  F +++   +LR  +    P  + +   +  ++ +++ FL  +E  
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPL-NILPMVISSIVQASVSLKRLRIFLSHEELE 626

Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
                 + ++    T  + + N T  W                                 
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656

Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
               P L  I F I  G L+AV G  G GK+SLL  ++ E++  EG +   G        
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------- 706

Query: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
                          +S  + +  S+ +A     DI  F                     
Sbjct: 707 -------------VNLSGGQKQRVSLARAVYSNADIYLF--------------------- 732

Query: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKK 612
                     D  L  +D+  G       K IFE+ +    ++ NKTRILVT  M +L +
Sbjct: 733 ----------DDPLSAVDAHVG-------KHIFENVIGPKGMLKNKTRILVTHSMSYLPQ 775

Query: 613 ADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
            D I+++  G     G++ EL      F+  L    S +Q      N +
Sbjct: 776 VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 824



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)

Query: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
            VL+ IN  I  G+ + + G TGAGK+SL + +    E +EG+I   G             
Sbjct: 1250 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1309

Query: 487  RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
            +I+   Q   +  G+++ N+     Y +    + ++   L++ +S   +K +    EGG 
Sbjct: 1310 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1369

Query: 547  TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
             LS GQR  + LARA+ +   + +LD     +D+ T+ ++ +S +     + T + +  +
Sbjct: 1370 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1428

Query: 607  MEHLKKADKILILHEGSSYFYGTFSEL 633
            +  +    ++++L +G    YG  S+L
Sbjct: 1429 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1455



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 3/84 (3%)

Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
            +E   +++  +   GG   +TV++ T  +       L  I+FSI  G  V ++G+ G GK
Sbjct: 625  LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684

Query: 1251 STLLSAFLRLLN-TEGEIQIDGVS 1273
            S+LLSA L  ++  EG + I GV+
Sbjct: 685  SSLLSALLAEMDKVEGHVAIKGVN 708



 Score = 40.8 bits (94), Expect = 0.010
 Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 3/100 (3%)

Query: 1343 GCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTL--KQAFADCTVIL 1399
            G  LS G KQ + LAR+V S A I L D+P + +D  V   I    +  K    + T IL
Sbjct: 706  GVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRIL 765

Query: 1400 CEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQ 1439
              H +  + +    +V+   K+ +  S Q+LL     F +
Sbjct: 766  VTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAE 805


>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
            [Homo sapiens]
          Length = 1531

 Score =  276 bits (706), Expect = 1e-73
 Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)

Query: 917  YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
            Y  +G++  +   G+   + +   L   S+ LH  +LHS+L++PMS      +G ++NRF
Sbjct: 1019 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1076

Query: 977  SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
            SK++  +D ++P  I  F+  L  VIGA  V+ +  P   +   P+ + +  ++ +++ +
Sbjct: 1077 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1136

Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
            S+QLK+LES  RSP+++H   +L G+  +RAF  Q  F       ++ +   ++  +   
Sbjct: 1137 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1196

Query: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
            RW  +R+E +   I   A  F  I       G VG+ ++ ++ + + L W V  S ++++
Sbjct: 1197 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1256

Query: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
             + +V R+ ++ +   E     + T P  +                   WP  G++  ++
Sbjct: 1257 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1297

Query: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
               +Y E  + +L +I+ +I+ G++VG++GRTG+GKS+L     R+  + EGEI IDG++
Sbjct: 1298 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1357

Query: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
               I L   R    +IPQ   +FSG+ R NLDP+ Q+SD+E+W   +   L+  +   P 
Sbjct: 1358 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1417

Query: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
            KLD    +GG  LS G +QL+CLAR++L K KIL+LDE +A +D  T  +I+ T++  F 
Sbjct: 1418 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1477

Query: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
            DCTV+   HR+  +++  + +V+++ ++++Y +   LL +R LF
Sbjct: 1478 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1521



 Score =  259 bits (662), Expect = 1e-68
 Identities = 178/709 (25%), Positives = 317/709 (44%), Gaps = 86/709 (12%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
           P   AS +S++ F W   ++ +GYRQ LE SD++ +   D+++ +   L + W +E A  
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268

Query: 65  K----------------------------------------NPKLINALRRCFFWRFMFY 84
           +                                        NP L   L + F   F+  
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328

Query: 85  GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
             F  + ++     P +L +++  +  D K       +  + L +   ++TL+LH     
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387

Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
               GM+++ A+   +Y+K L +++      ++G++V+L+S +  +F +     + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447

Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
           PLQV L + L+W  L  S   G+  ++++    A +      Y+         R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507

Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
           ++  I+ +K Y WE A +  +  +RQ ELK+ +K+AY+    +  +  + F V   +   
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567

Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
           Y  I     +  +  F +++   +LR  +    P  + +   +  ++ +++ FL  +E  
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELE 626

Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
                 + ++    T  + + N T  W                                 
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656

Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
               P L  I F I  G L+AV G  G GK+SLL  ++ E++  EG +   G +++  Q 
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQ 714

Query: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
           +WI   +++ENI+FG   +E  YRSVI+AC L  D+      D   +GE G+ LSGGQ+ 
Sbjct: 715 AWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQ 774

Query: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKK 612
           R+SLARAVY +AD+YL D P   +D    K IFE+ +    ++ NKTRILVT  M +L +
Sbjct: 775 RVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQ 834

Query: 613 ADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
            D I+++  G     G++ EL      F+  L    S +Q      N +
Sbjct: 835 VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 883



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 68/253 (26%), Positives = 113/253 (44%), Gaps = 19/253 (7%)

Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
            +E   +++  +   GG   +TV++ T  +       L  I+FSI  G  V ++G+ G GK
Sbjct: 625  LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684

Query: 1251 STLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQ 1309
            S+LLSA L  ++  EG + I G             +   +PQ+ +I + + R+N+    Q
Sbjct: 685  SSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQ 731

Query: 1310 WSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLL 1369
              +     V     L   +E  P      + + G  LS G KQ + LAR+V S A I L 
Sbjct: 732  LEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLF 791

Query: 1370 DEPSAHLDP-VTYQIIRRTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDS 1426
            D+P + +D  V   I    +  K    + T IL  H +  + +    +V+   K+ +  S
Sbjct: 792  DDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGS 851

Query: 1427 IQKLLNERSLFRQ 1439
             Q+LL     F +
Sbjct: 852  YQELLARDGAFAE 864



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)

Query: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
            VL+ IN  I  G+ + + G TGAGK+SL + +    E +EG+I   G             
Sbjct: 1309 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1368

Query: 487  RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
            +I+   Q   +  G+++ N+     Y +    + ++   L++ +S   +K +    EGG 
Sbjct: 1369 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1428

Query: 547  TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
             LS GQR  + LARA+ +   + +LD     +D+ T+ ++ +S +     + T + +  +
Sbjct: 1429 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1487

Query: 607  MEHLKKADKILILHEGSSYFYGTFSEL 633
            +  +    ++++L +G    YG  S+L
Sbjct: 1488 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1514


>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
            sapiens]
          Length = 1464

 Score =  266 bits (680), Expect = 1e-70
 Identities = 170/546 (31%), Positives = 291/546 (53%), Gaps = 33/546 (6%)

Query: 911  SSYYVFY--IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
            SS   FY  +Y  +A         R +      +  +  LH ++LH VL AP++  N   
Sbjct: 933  SSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992

Query: 969  AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
             G ILNRFS D+A  DD LP  +   +     ++G +AV+    P++ +   P+ + +  
Sbjct: 993  TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH 1052

Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
            ++ ++  +S++L++L S   SP+++HL  +L GL  LRA G    FE    + L L+   
Sbjct: 1053 VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC 1112

Query: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEG---EGRVGIILTLAMNIMSTLQW 1145
             F   +T++W  +R++++      A+  I+++   +G    G VG+ L+ A+++   L  
Sbjct: 1113 QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG 1172

Query: 1146 AVNSSIDVDSLMRSVSRVFKF-IDMPTE--GKPTKSTKPYKNGQLSKVMIIENSHVKKDD 1202
             V+S    ++++ SV R+ ++  D+P E  G+P                      ++   
Sbjct: 1173 LVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQP----------------------LQLGT 1210

Query: 1203 IWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN 1262
             W + G +  +D+   Y  G    L+ ++F + PG+++G++GRTGSGKS+LL    RLL 
Sbjct: 1211 GWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 1270

Query: 1263 -TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADE 1321
             + G + +DGV    + L Q R    +IPQ+ F+FSGT R+NLDP     D+ +W+   +
Sbjct: 1271 PSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQ 1330

Query: 1322 VGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTY 1381
              L  VI    G LD  L +GG  LS G +QL+CLAR++L+ AKIL +DE +A +D  T 
Sbjct: 1331 CHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTD 1389

Query: 1382 QIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNE-RSLFRQA 1440
            Q++++T+ + FA+ TV+   HR+  +L   + LV++  +V + DS   L N+  SLF+Q 
Sbjct: 1390 QLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQL 1449

Query: 1441 ISPSDR 1446
            +  S +
Sbjct: 1450 LQSSQQ 1455



 Score =  210 bits (535), Expect = 7e-54
 Identities = 157/637 (24%), Positives = 298/637 (46%), Gaps = 42/637 (6%)

Query: 10  SVVSKLFFSWTRPILRKGYRQRL-ELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPK 68
           S +S+  ++W  P+L +G    L +  DI ++P       L+   +  W      ++  +
Sbjct: 176 SWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHW------QEGAR 229

Query: 69  LINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLC 128
           L  AL   F   ++  G+   +G +     PLLL  ++   + + +E  S  +   +GL 
Sbjct: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLE-EGQEPLSHGLLYALGLA 288

Query: 129 LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNL 188
              ++  +L +   + ++ + +Q R A+ +++Y K L+L      +   G+ ++LL  + 
Sbjct: 289 GGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGP---SRPPTGEALNLLGTDS 345

Query: 189 NKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYR 248
            +        H  W  PLQ+A+ + L+++ +  +   GL   ++L      +   +M   
Sbjct: 346 ERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASN 405

Query: 249 DQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSS 308
            +       R+ + +E++  I+ +K   WE+A+   +E  R  EL   R    ++Y +++
Sbjct: 406 QEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLR---VIKYLDAA 462

Query: 309 AFFFSGFFVVFLSV---LPYALI-KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDS 364
             +      V +S+   + Y L+   +   K+FT ++   +L + +   FPW +    ++
Sbjct: 463 CVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPLNN-FPWVINGLLEA 521

Query: 365 LGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNG 424
             ++++IQ FL    +               N  A++    G L  + K    +   +  
Sbjct: 522 KVSLDRIQLFLDLPNH---------------NPQAYYSPDCGRLGAQIKWLLCSDPPAEP 566

Query: 425 DDSLFFSNFSLLGTPVLKDI-----NFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSE 479
              L          PV   +     + ++++G L+ + G  G GK+SLL  I GEL    
Sbjct: 567 STVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLR 626

Query: 480 GKIKHSGR---ISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEK 536
           G +   G        +Q  WI   TI++NI+FG ++D   Y+ V++AC L +D+S     
Sbjct: 627 GHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAG 686

Query: 537 DNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMA 596
           D   +GE G+TLSGGQRARI+LARAVY++ +LYLLD P   +D      +   C+  +++
Sbjct: 687 DQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLS 746

Query: 597 NKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
             TR+L T + E+L++AD +L++  G     G  SE+
Sbjct: 747 YTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEI 783



 Score = 99.0 bits (245), Expect = 3e-20
 Identities = 59/195 (30%), Positives = 102/195 (52%), Gaps = 15/195 (7%)

Query: 441  LKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-------------R 487
            L  + F ++ G+ L + G TG+GK+SLL+V+   LEPS G++   G             +
Sbjct: 1235 LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQ 1294

Query: 488  ISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGIT 547
            ++   Q  ++  GT++EN+     + +      +K C L E I+     D   LGEGG +
Sbjct: 1295 LAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDG-ELGEGGRS 1353

Query: 548  LSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKM 607
            LS GQR  + LARA+  DA +  +D     +D  T+ ++ +  +CK  ANKT + +  ++
Sbjct: 1354 LSLGQRQLLCLARALLTDAKILCIDEATASVDQKTD-QLLQQTICKRFANKTVLTIAHRL 1412

Query: 608  EHLKKADKILILHEG 622
              +  +D++L+L  G
Sbjct: 1413 NTILNSDRVLVLQAG 1427



 Score = 73.9 bits (180), Expect = 1e-12
 Identities = 98/443 (22%), Positives = 178/443 (40%), Gaps = 37/443 (8%)

Query: 987  LPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESE 1046
            LPL +   + LL   +G   V  ++   + V    VI   IM       ++Q++ Q   +
Sbjct: 361  LPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMA------SNQEMLQ-HKD 413

Query: 1047 GRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFH--KALNLHTANWFLYLSTL---RWFQM 1101
             R  + T L   L G+  ++  G +          +A  L       YL       W  +
Sbjct: 414  ARVKLVTEL---LSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAAL 470

Query: 1102 RIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVS 1161
             + +  VIF   V     LT  +    + ++  L + + +   W +N  ++      S+ 
Sbjct: 471  PVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPL-NNFPWVINGLLEAKV---SLD 526

Query: 1162 RVFKFIDMPTEGKPTK-STKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYT 1220
            R+  F+D+P        S    + G   K ++  +   +   +    G +   D      
Sbjct: 527  RIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSL 586

Query: 1221 EGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITL 1279
            E   + LE     +  G  VG++G+ G GKS+LL+A    L    G + + G+S      
Sbjct: 587  ETFISHLE-----VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLS------ 635

Query: 1280 QQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVL 1339
                K FG+  Q+ +I   T R N+   + +  Q   +V +   L   +   P      +
Sbjct: 636  ----KGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEV 691

Query: 1340 VDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD-PVTYQIIRRTLKQAFADCTVI 1398
             + G  LS G +  + LAR+V  + ++ LLD+P A +D  V   ++ R +    +  T +
Sbjct: 692  GEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRL 751

Query: 1399 LCEHRIEAMLECQQFLVIEENKV 1421
            LC HR E +      L++E  ++
Sbjct: 752  LCTHRTEYLERADAVLLMEAGRL 774


>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
           [Homo sapiens]
          Length = 1466

 Score =  259 bits (662), Expect = 1e-68
 Identities = 178/709 (25%), Positives = 317/709 (44%), Gaps = 86/709 (12%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
           P   AS +S++ F W   ++ +GYRQ LE SD++ +   D+++ +   L + W +E A  
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268

Query: 65  K----------------------------------------NPKLINALRRCFFWRFMFY 84
           +                                        NP L   L + F   F+  
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328

Query: 85  GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
             F  + ++     P +L +++  +  D K       +  + L +   ++TL+LH     
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387

Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
               GM+++ A+   +Y+K L +++      ++G++V+L+S +  +F +     + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447

Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
           PLQV L + L+W  L  S   G+  ++++    A +      Y+         R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507

Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
           ++  I+ +K Y WE A +  +  +RQ ELK+ +K+AY+    +  +  + F V   +   
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567

Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
           Y  I     +  +  F +++   +LR  +    P  + +   +  ++ +++ FL  +E  
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELE 626

Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
                 + ++    T  + + N T  W                                 
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656

Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
               P L  I F I  G L+AV G  G GK+SLL  ++ E++  EG +   G +++  Q 
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQ 714

Query: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
           +WI   +++ENI+FG   +E  YRSVI+AC L  D+      D   +GE G+ LSGGQ+ 
Sbjct: 715 AWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQ 774

Query: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKK 612
           R+SLARAVY +AD+YL D P   +D    K IFE+ +    ++ NKTRILVT  M +L +
Sbjct: 775 RVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQ 834

Query: 613 ADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
            D I+++  G     G++ EL      F+  L    S +Q      N +
Sbjct: 835 VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 883



 Score =  204 bits (519), Expect = 5e-52
 Identities = 122/429 (28%), Positives = 224/429 (52%), Gaps = 22/429 (5%)

Query: 917  YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
            Y  +G++  +   G+   + +   L   S+ LH  +LHS+L++PMS      +G ++NRF
Sbjct: 1019 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1076

Query: 977  SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
            SK++  +D ++P  I  F+  L  VIGA  V+ +  P   +   P+ + +  ++ +++ +
Sbjct: 1077 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1136

Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
            S+QLK+LES  RSP+++H   +L G+  +RAF  Q  F       ++ +   ++  +   
Sbjct: 1137 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1196

Query: 1097 RWFQMRIEMI-FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
            RW  +R+E +   I   A  F  I       G VG+ ++ ++ + + L W V  S ++++
Sbjct: 1197 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1256

Query: 1156 LMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDL 1215
             + +V R+ ++ +       T+   P+           +         WP  G++  ++ 
Sbjct: 1257 NIVAVERLKEYSE-------TEKEAPW-----------QIQETAPPSSWPQVGRVEFRNY 1298

Query: 1216 TAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL-LNTEGEIQIDGVSW 1274
              +Y E  + +L +I+ +I+ G++VG++GRTG+GKS+L     R+  + EGEI IDG++ 
Sbjct: 1299 CLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINI 1358

Query: 1275 DSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
              I L   R    +IPQ   +FSG+ R NLDP+ Q+SD+E+W   +   L+  +   P K
Sbjct: 1359 AKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDK 1418

Query: 1335 LDFVLVDGG 1343
            LD    +GG
Sbjct: 1419 LDHECAEGG 1427



 Score = 75.9 bits (185), Expect = 3e-13
 Identities = 68/253 (26%), Positives = 113/253 (44%), Gaps = 19/253 (7%)

Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
            +E   +++  +   GG   +TV++ T  +       L  I+FSI  G  V ++G+ G GK
Sbjct: 625  LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684

Query: 1251 STLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQ 1309
            S+LLSA L  ++  EG + I G             +   +PQ+ +I + + R+N+    Q
Sbjct: 685  SSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQ 731

Query: 1310 WSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLL 1369
              +     V     L   +E  P      + + G  LS G KQ + LAR+V S A I L 
Sbjct: 732  LEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLF 791

Query: 1370 DEPSAHLDP-VTYQIIRRTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDS 1426
            D+P + +D  V   I    +  K    + T IL  H +  + +    +V+   K+ +  S
Sbjct: 792  DDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGS 851

Query: 1427 IQKLLNERSLFRQ 1439
             Q+LL     F +
Sbjct: 852  YQELLARDGAFAE 864



 Score = 41.6 bits (96), Expect = 0.006
 Identities = 31/122 (25%), Positives = 56/122 (45%), Gaps = 13/122 (10%)

Query: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
            VL+ IN  I  G+ + + G TGAGK+SL + +    E +EG+I   G             
Sbjct: 1309 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1368

Query: 487  RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
            +I+   Q   +  G+++ N+     Y +    + ++   L++ +S   +K +    EGG 
Sbjct: 1369 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1428

Query: 547  TL 548
             L
Sbjct: 1429 NL 1430


>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
            [Homo sapiens]
          Length = 1503

 Score =  252 bits (644), Expect = 2e-66
 Identities = 163/533 (30%), Positives = 272/533 (51%), Gaps = 27/533 (5%)

Query: 921  GVADTLLAMGFFRGLPLVHTL-ITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKD 979
            G+   L A+G F  +  V       S++L  ++L  V+++P+S       G +LNRFSK+
Sbjct: 992  GLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKE 1051

Query: 980  IAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQ 1039
               +D  +P  +   +     ++    VVAV  P   VA +P+ + +   ++ ++ +S Q
Sbjct: 1052 TDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQ 1111

Query: 1040 LKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWF 1099
            L++LES   S + +H+  + +G   +RAF  Q  F    +  ++      F  L   RW 
Sbjct: 1112 LRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWL 1171

Query: 1100 QMRIEMIFVIFFIAVTFISILTTGE-GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMR 1158
               +E++      A    ++L+      G VG  ++ A+ +  TLQW V +  D+++ + 
Sbjct: 1172 AANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIV 1231

Query: 1159 SVSRVFKFIDMPTEGK---PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDL 1215
            SV R+  +   P E     PT + +P                      WP GGQ+  +D 
Sbjct: 1232 SVERMQDYAWTPKEAPWRLPTCAAQPP---------------------WPQGGQIEFRDF 1270

Query: 1216 TAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVSW 1274
              +Y       ++ +SF I  G++VG++GRTG+GKS+L S  LRL    EG I IDGV  
Sbjct: 1271 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1330

Query: 1275 DSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
              + L   R    +IPQ   +F G+ R NLD  ++ SD+ IW   + V L++++   PG+
Sbjct: 1331 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQ 1390

Query: 1335 LDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFAD 1394
            L +   D G  LS G KQL+CLAR++L K +IL+LDE +A +DP T   ++  L   FA 
Sbjct: 1391 LQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQ 1450

Query: 1395 CTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRV 1447
            CTV+L  HR+ ++++C + LV+++ +V +  S  +LL ++ LF +    S  V
Sbjct: 1451 CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1503



 Score =  219 bits (558), Expect = 2e-56
 Identities = 165/668 (24%), Positives = 307/668 (45%), Gaps = 70/668 (10%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL-AS 63
           P   A+  SK  F W   ++ +GYR+ L   D++ +   +S++ L  +LE+EW R   A+
Sbjct: 204 PETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 263

Query: 64  KKNPK------------------------------LINALRRCFFWRFMFYGIFLYLGEV 93
           +++ K                              L+ A+ + F   F+   + L + +V
Sbjct: 264 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDV 323

Query: 94  TKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMR 153
            +   P LL  +   +  D K        L + + L   ++TL     ++ L  + M++R
Sbjct: 324 FRFTVPKLLS-LFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLR 382

Query: 154 IAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMG 213
            A+  L+Y+K L LSS      ++G +V+L+S ++ +  E +   + +W+  + + +   
Sbjct: 383 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442

Query: 214 LIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVK 273
            +W+LL  SA   +   + L      + +    +++++  +   R  +TS ++ N +++K
Sbjct: 443 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIK 502

Query: 274 AYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALI--KGI 331
            + WE A    +  +R  EL   R +  +   +  +F  S F V  +    + L+    +
Sbjct: 503 FHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 562

Query: 332 ILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTE 391
              K F T++   +L  A     P+++ +   +  + +++  FL  +E            
Sbjct: 563 NAEKAFVTLTVLNILNKAQAF-LPFSIHSLVQARVSFDRLVTFLCLEEV----------- 610

Query: 392 VVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN----FSLLGTPVLKDINFK 447
                             +    ++++  ++ G D +   +    +S    P L  IN  
Sbjct: 611 ------------------DPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLT 652

Query: 448 IERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENII 507
           + +G LLAV G  GAGK+SLL  ++GEL   EG +   G +++  Q +W+   ++ EN+ 
Sbjct: 653 VPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVC 712

Query: 508 FGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDAD 567
           FG   D      V++AC L+ D+  F E  +  +GE G+ LSGGQ+ R+SLARAVY+ A 
Sbjct: 713 FGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAA 772

Query: 568 LYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKKADKILILHEGSSY 625
           +YLLD P   LD    + +F   +    L+   TRILVT  +  L +AD I++L  G+  
Sbjct: 773 VYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIA 832

Query: 626 FYGTFSEL 633
             G++ EL
Sbjct: 833 EMGSYQEL 840



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 63/245 (25%), Positives = 113/245 (46%), Gaps = 21/245 (8%)

Query: 1210 MTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQ 1268
            +T+   T  +++     L  I+ ++  G  + ++G  G+GKS+LLSA L  L   EG + 
Sbjct: 629  ITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 688

Query: 1269 IDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVI 1328
            I+G             A   +PQ+ ++ + +  +N+   ++     + +V +   L+  +
Sbjct: 689  IEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 735

Query: 1329 EQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRT 1387
            + FP  +   + + G  LS G KQ + LAR+V  KA + LLD+P A LD  V   +  + 
Sbjct: 736  DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 795

Query: 1388 LKQA--FADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS----LFRQAI 1441
            +         T IL  H +  + +    +V+    + +  S Q+LL  +     L  QA 
Sbjct: 796  IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQAR 855

Query: 1442 SPSDR 1446
             P DR
Sbjct: 856  QPGDR 860



 Score = 70.1 bits (170), Expect = 2e-11
 Identities = 68/314 (21%), Positives = 133/314 (42%), Gaps = 49/314 (15%)

Query: 340  ISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQEYKTLEYNLTTTEVVMEN 396
            + F +   + VT+   W V+ W D   S+ ++ ++QD+      K   + L T       
Sbjct: 1202 VGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP--KEAPWRLPTCAAQPP- 1258

Query: 397  VTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVL----KDINFKIERGQ 452
                W +G                       + F +F L   P L    + ++FKI  G+
Sbjct: 1259 ----WPQG---------------------GQIEFRDFGLRYRPELPLAVQGVSFKIHAGE 1293

Query: 453  LLAVAGSTGAGKTSLLMVIMGELEPSEG-------KIKHSG------RISFCSQFSWIMP 499
             + + G TGAGK+SL   ++   E +EG        I H G      RIS   Q   + P
Sbjct: 1294 KVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFP 1353

Query: 500  GTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLA 559
            G+++ N+     + +    + ++  QL+  ++    +      + G  LS GQ+  + LA
Sbjct: 1354 GSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLA 1413

Query: 560  RAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILIL 619
            RA+ +   + +LD     +D  TE ++ ++ +    A  T +L+  ++  +    ++L++
Sbjct: 1414 RALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVM 1472

Query: 620  HEGSSYFYGTFSEL 633
             +G     G+ ++L
Sbjct: 1473 DKGQVAESGSPAQL 1486


>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1312

 Score =  252 bits (643), Expect = 2e-66
 Identities = 163/533 (30%), Positives = 272/533 (51%), Gaps = 27/533 (5%)

Query: 921  GVADTLLAMGFFRGLPLVHTL-ITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKD 979
            G+   L A+G F  +  V       S++L  ++L  V+++P+S       G +LNRFSK+
Sbjct: 801  GLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKE 860

Query: 980  IAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQ 1039
               +D  +P  +   +     ++    VVAV  P   VA +P+ + +   ++ ++ +S Q
Sbjct: 861  TDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQ 920

Query: 1040 LKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWF 1099
            L++LES   S + +H+  + +G   +RAF  Q  F    +  ++      F  L   RW 
Sbjct: 921  LRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWL 980

Query: 1100 QMRIEMIFVIFFIAVTFISILTTGE-GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMR 1158
               +E++      A    ++L+      G VG  ++ A+ +  TLQW V +  D+++ + 
Sbjct: 981  AANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIV 1040

Query: 1159 SVSRVFKFIDMPTEGK---PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDL 1215
            SV R+  +   P E     PT + +P                      WP GGQ+  +D 
Sbjct: 1041 SVERMQDYAWTPKEAPWRLPTCAAQPP---------------------WPQGGQIEFQDF 1079

Query: 1216 TAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVSW 1274
              +Y       ++ +SF I  G++VG++GRTG+GKS+L S  LRL    EG I IDGV  
Sbjct: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139

Query: 1275 DSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
              + L   R    +IPQ   +F G+ R NLD  ++ SD+ IW   + V L++++   PG+
Sbjct: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQ 1199

Query: 1335 LDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFAD 1394
            L +   D G  LS G KQL+CLAR++L K +IL+LDE +A +DP T   ++  L   FA 
Sbjct: 1200 LQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQ 1259

Query: 1395 CTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRV 1447
            CTV+L  HR+ ++++C + LV+++ +V +  S  +LL ++ LF +    S  V
Sbjct: 1260 CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312



 Score =  220 bits (560), Expect = 9e-57
 Identities = 165/668 (24%), Positives = 307/668 (45%), Gaps = 70/668 (10%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL-AS 63
           P   A+  SK  F W   ++ +GYR+ L   D++ +   +S++ L  +LE+EW R   A+
Sbjct: 13  PETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 72

Query: 64  KKNPK------------------------------LINALRRCFFWRFMFYGIFLYLGEV 93
           +++ K                              L+ A+ + F   F+   + L + +V
Sbjct: 73  RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDV 132

Query: 94  TKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMR 153
            +   P LL  +   +  D K        L + + L   ++TL     ++ L  + M++R
Sbjct: 133 FRFTVPKLLS-LFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLR 191

Query: 154 IAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMG 213
            A+  L+Y+K L LSS      ++G +V+L+S ++ +  E +   + +W+  + + +   
Sbjct: 192 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251

Query: 214 LIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVK 273
            +W+LL  SA   +   + L      + +    +++++  +   R  +TS ++ N +++K
Sbjct: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIK 311

Query: 274 AYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALI--KGI 331
            + WE A    +  +R  EL   R +  +   +  +F  S F V  +    + L+    +
Sbjct: 312 FHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 371

Query: 332 ILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTE 391
              K F T++   +L  A     P+++ +   +  + +++  FL  +E            
Sbjct: 372 NAEKAFVTLTVLNILNKAQAF-LPFSIHSLVQARVSFDRLVTFLCLEEV----------- 419

Query: 392 VVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN----FSLLGTPVLKDINFK 447
                             +    ++++  ++ G D +   +    +S    P L  IN  
Sbjct: 420 ------------------DPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLT 461

Query: 448 IERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENII 507
           + +G LLAV G  GAGK+SLL  ++GEL   EG +   G +++  Q +W+   ++ EN+ 
Sbjct: 462 VPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVC 521

Query: 508 FGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDAD 567
           FG   D      V++AC L+ D+  F E  +  +GE G+ LSGGQ+ R+SLARAVY+ A 
Sbjct: 522 FGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAA 581

Query: 568 LYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKKADKILILHEGSSY 625
           +YLLD P   LD    + +F   +    L+   TRILVT  +  L +AD I++L  G+  
Sbjct: 582 VYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIA 641

Query: 626 FYGTFSEL 633
             G++ EL
Sbjct: 642 EMGSYQEL 649



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 63/245 (25%), Positives = 114/245 (46%), Gaps = 21/245 (8%)

Query: 1210 MTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQ 1268
            +T++  T  +++     L  I+ ++  G  + ++G  G+GKS+LLSA L  L   EG + 
Sbjct: 438  ITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 497

Query: 1269 IDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVI 1328
            I+G             A   +PQ+ ++ + +  +N+   ++     + +V +   L+  +
Sbjct: 498  IEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 544

Query: 1329 EQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRT 1387
            + FP  +   + + G  LS G KQ + LAR+V  KA + LLD+P A LD  V   +  + 
Sbjct: 545  DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 604

Query: 1388 LKQA--FADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS----LFRQAI 1441
            +         T IL  H +  + +    +V+    + +  S Q+LL  +     L  QA 
Sbjct: 605  IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQAR 664

Query: 1442 SPSDR 1446
             P DR
Sbjct: 665  QPGDR 669



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 68/314 (21%), Positives = 133/314 (42%), Gaps = 49/314 (15%)

Query: 340  ISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQEYKTLEYNLTTTEVVMEN 396
            + F +   + VT+   W V+ W D   S+ ++ ++QD+      K   + L T       
Sbjct: 1011 VGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP--KEAPWRLPTCAAQPP- 1067

Query: 397  VTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVL----KDINFKIERGQ 452
                W +G                       + F +F L   P L    + ++FKI  G+
Sbjct: 1068 ----WPQG---------------------GQIEFQDFGLRYRPELPLAVQGVSFKIHAGE 1102

Query: 453  LLAVAGSTGAGKTSLLMVIMGELEPSEG-------KIKHSG------RISFCSQFSWIMP 499
             + + G TGAGK+SL   ++   E +EG        I H G      RIS   Q   + P
Sbjct: 1103 KVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFP 1162

Query: 500  GTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLA 559
            G+++ N+     + +    + ++  QL+  ++    +      + G  LS GQ+  + LA
Sbjct: 1163 GSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLA 1222

Query: 560  RAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILIL 619
            RA+ +   + +LD     +D  TE ++ ++ +    A  T +L+  ++  +    ++L++
Sbjct: 1223 RALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVM 1281

Query: 620  HEGSSYFYGTFSEL 633
             +G     G+ ++L
Sbjct: 1282 DKGQVAESGSPAQL 1295


>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
           [Homo sapiens]
          Length = 1344

 Score =  250 bits (639), Expect = 6e-66
 Identities = 180/642 (28%), Positives = 314/642 (48%), Gaps = 20/642 (3%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
           PL+ A + S L  SW  P++ +  R RL+ + I  +   D++D   ++L R W+ E++ +
Sbjct: 85  PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRR 144

Query: 65  --KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIY 122
             +   ++  + R    R +F  +      +   + P+L+   I  Y     EE+   + 
Sbjct: 145 GIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS----EEQLGNVV 200

Query: 123 LGIGLCL-LFI---VRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
            G+GLC  LF+   V++L    +        ++ R A+ S  ++K ++  S +   I+ G
Sbjct: 201 HGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVI--HITSG 258

Query: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
           + +S  + ++N   EG+     V I    + +     + ++  +AF  +   +++     
Sbjct: 259 EAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAV 318

Query: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
            + RM +K +   +    +R+ +TSE++  I+ +K Y WE+   K+IE+LR+ E KL  K
Sbjct: 319 FMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEK 378

Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK-GIILRKIFTTISFCIVLRMAVTRQFPWA 357
              V+   S   F        + VL +  +K  +     F+ ++   +LR++V    P A
Sbjct: 379 CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF-VPIA 437

Query: 358 VQTWYDSLGAINKIQDFLQKQEYKTLEYNLT--TTEVVMENVTAFWEEGFGELFEKAKQN 415
           V+   +S  A+ + + F  ++        L   +  +V E  T  W++    +   A + 
Sbjct: 438 VKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALEL 497

Query: 416 NNNRKTSNG----DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471
             N   S G     D+L          P L  IN  + +G +L V G+TG+GK+SLL  I
Sbjct: 498 ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557

Query: 472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDIS 531
           + E+   EG +   G +++  Q +WI+ G I+ENI+ G +YD+ RY  V+  C L  D+ 
Sbjct: 558 LEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617

Query: 532 KFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV 591
                D   +GE G+ LSGGQ+ RISLARAVY D  +YLLD P   +D    K IFE C+
Sbjct: 618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI 677

Query: 592 CKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
            K +  KT +LVT ++++L+   +I++L  G     GT SEL
Sbjct: 678 KKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSEL 719



 Score =  233 bits (595), Expect = 8e-61
 Identities = 174/658 (26%), Positives = 302/658 (45%), Gaps = 82/658 (12%)

Query: 781  QNIHRKTTAS----TRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836
            Q +H++ T+     T K++  P+             SQ     + E +N   + E     
Sbjct: 731  QKMHKEATSDMLQDTAKIAEKPKVE-----------SQALATSLEESLNGNAVPEHQLTQ 779

Query: 837  MESIPAVT-TWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVL--WLLGNTPLQDKG 893
             E +   + +W  Y  YI         ++ C++ F   +   L +   W L     Q  G
Sbjct: 780  EEEMEEGSLSWRVYHHYIQAAGGY---MVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSG 836

Query: 894  -NSTHSRNNSYAVI--ITSTSSYYVFYIYVGV-ADTLLAMGFFRGLPLVHTLITVSKILH 949
             NS+   N + A +  I        + +  G+ A  L+ +G              S  LH
Sbjct: 837  TNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALH 896

Query: 950  HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
            +K+ + V + PMS  +T+  G +LN F+ D+  LD LLP+    F+ L L+VI  + +V+
Sbjct: 897  NKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVS 956

Query: 1010 VLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFG 1069
            VL PYI +    ++V   +    F +     K+LE+  RSP+F+H++ SL+GL ++  +G
Sbjct: 957  VLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYG 1016

Query: 1070 RQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT-FISILTTGEGEGR 1128
            +   F + F +  +       L+LS+ RW  +R+E++  +  +AV  F++   +      
Sbjct: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076

Query: 1129 VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLS 1188
              + + + + + S+ Q      ++ ++   +V R+ +++ M     P             
Sbjct: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP------------- 1123

Query: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGS 1248
              + +E +   +   WP  G++  +D   KY +    +L  I+ +I   + VG++GRTGS
Sbjct: 1124 --LHMEGTSCPQG--WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179

Query: 1249 GKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPY 1307
            GKS+L  A  RL+    G I IDGV   SI L+  R    VIPQ   + SGT R NLDP+
Sbjct: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239

Query: 1308 EQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367
            ++ +DQ+IW                                       L R+ L+KA I+
Sbjct: 1240 DRHTDQQIWD-------------------------------------ALERTFLTKA-II 1261

Query: 1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYD 1425
            L+DE +A +D  T  +I+RT+++AF  CTV++  HR+  +L C   LV+   KV ++D
Sbjct: 1262 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1319



 Score = 90.5 bits (223), Expect = 1e-17
 Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 21/263 (7%)

Query: 1221 EGGNAI---LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDS 1276
            E GN++   L  I+  +S G  +G+ G TGSGKS+LLSA L  ++  EG + + G     
Sbjct: 518  EEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG----- 572

Query: 1277 ITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLD 1336
                    +   +PQ+ +I SG  R+N+     +      +V     L   +E  P    
Sbjct: 573  --------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM 624

Query: 1337 FVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADC 1395
              + + G  LS G KQ + LAR+V S  +I LLD+P + +D  V   I    +K+     
Sbjct: 625  TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684

Query: 1396 TVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH-RN 1454
            TV+L  H+++ +  C Q +++E  K+ +  +  +L+ ++  + Q I    +       ++
Sbjct: 685  TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744

Query: 1455 SSKCKSKPQI--AALKEETEEEV 1475
            ++K   KP++   AL    EE +
Sbjct: 745  TAKIAEKPKVESQALATSLEESL 767



 Score = 37.4 bits (85), Expect = 0.11
 Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 1/53 (1%)

Query: 440  VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCS 492
            VL  IN  I   +++ + G TG+GK+SL M +   +EP  G+I   G +  CS
Sbjct: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDG-VDICS 1208


>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
           [Homo sapiens]
          Length = 572

 Score =  117 bits (293), Expect = 8e-26
 Identities = 84/341 (24%), Positives = 155/341 (45%), Gaps = 30/341 (8%)

Query: 5   PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE---- 60
           P   A  +S+LFF W   +   GYR  LE  D++ +   D +  + ++L   W ++    
Sbjct: 208 PETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQT 267

Query: 61  ------LASKKN-----------------PKLINALRRCFFWRFMFYGIFLYLGEVTKAV 97
                  A  KN                 P  + AL   F   F+    F  + ++   +
Sbjct: 268 ARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFI 327

Query: 98  QPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLF-IVRTLLLHPAIFGLHHIGMQMRIAM 156
            P LL  +I      N    S   +L  GL  L  ++++L+L      +   G++ R  +
Sbjct: 328 NPQLLSILIRFIS--NPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGI 385

Query: 157 FSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIW 216
             +IY+K L +++ V    ++G++V+L+S +  +F +     + +W APLQ+ L +  +W
Sbjct: 386 MGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLW 445

Query: 217 ELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYC 276
           + L  S   G+ F+++L      +   M  ++ ++      R+ + SE++  I+ +K Y 
Sbjct: 446 QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYA 505

Query: 277 WEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFV 317
           WE +  K +E +RQ EL+L R AAY+    +  +  S F V
Sbjct: 506 WEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLV 546


>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
           sapiens]
          Length = 718

 Score =  115 bits (289), Expect = 2e-25
 Identities = 149/611 (24%), Positives = 264/611 (43%), Gaps = 106/611 (17%)

Query: 78  FWRFMF-------YGIFLYLGEVTKAVQ-PLLLGR---IIASYDPDN-----KEERSIAI 121
           FW+F+          + L LG     VQ PLLLG+   ++A Y  D+      E ++++ 
Sbjct: 120 FWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLST 179

Query: 122 YLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLV 181
           +L     +L+ V+ LL    +  L H+G +M + M   ++   L+      D    GQLV
Sbjct: 180 HL----LILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLV 235

Query: 182 SLLSNNLNKF--------DEGLALAHFVWIAPLQVALLMGLIWELLQAS--AFCGLGFLI 231
           S L+ ++ +F         +GL     V    + +++L   +  LL  +  A  G+G   
Sbjct: 236 SRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVG--- 292

Query: 232 VLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQT 291
              L  +GL ++  + ++Q    I+  + +  E + N+++V+A+    AME+  E     
Sbjct: 293 --TLMGSGLRKLSRQCQEQ----IARAMGVADEALGNVRTVRAF----AMEQREEERYGA 342

Query: 292 ELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISF-CIVLRMAV 350
           EL+  R  A                          L +GI L +  + I+F C+VL    
Sbjct: 343 ELEACRCRAE------------------------ELGRGIALFQGLSNIAFNCMVLG--- 375

Query: 351 TRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFE 410
           T     ++       G    +  FL   +  T++ ++    V+   V      G   +FE
Sbjct: 376 TLFIGGSLVAGQQLTGG--DLMSFLVASQ--TVQRSMANLSVLFGQVVRGLSAG-ARVFE 430

Query: 411 KAKQN------------NNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAG 458
               N                + S    ++ FS     G  VLKD    +  G+++A+ G
Sbjct: 431 YMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVG 490

Query: 459 STGAGKTSLLMVIMGELEPSEGKIKHSGR--------------ISFCSQFSWIMPGTIKE 504
            +G GKT++  ++    +P+ G +   GR              + F SQ   +   TI E
Sbjct: 491 QSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIME 550

Query: 505 NIIFGV--SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAV 562
           NI FG   + DE  Y +  +A    E I+ F E  N V+GE G TLSGGQ+ R+++ARA+
Sbjct: 551 NIRFGKLEASDEEVYTAAREA-NAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARAL 609

Query: 563 YKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEG 622
            K   + +LD     LD  +E+ + +  + +  A +T +++  ++  ++ A  I+++ +G
Sbjct: 610 IKQPTVLILDEATSALDAESER-VVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADG 668

Query: 623 SSYFYGTFSEL 633
             +  GT  EL
Sbjct: 669 RVWEAGTHEEL 679



 Score =  102 bits (254), Expect = 3e-21
 Identities = 131/628 (20%), Positives = 270/628 (42%), Gaps = 45/628 (7%)

Query: 846  WNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAV 905
            W  + +++  H   + VL   +V+ L     ++ +  LLG   ++     T     S+  
Sbjct: 117  WKLFWQFLHPH---LLVLGVAVVLALGAALVNVQIPLLLGQL-VEVVAKYTRDHVGSFMT 172

Query: 906  IITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLN 965
               + S++ +  I  GV   LL  G+   L  V   + V   +   +  S+L+  ++  +
Sbjct: 173  ESQNLSTHLL--ILYGVQG-LLTFGYLVLLSHVGERMAVD--MRRALFSSLLRQDITFFD 227

Query: 966  TLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVA 1025
              K G +++R + D+        L I   ++    V G +  +++L   +   T+ ++VA
Sbjct: 228  ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRL---TLLLMVA 284

Query: 1026 FIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTS---LKGLWTLRAFGRQPYFETLFHKAL 1082
               L          L++L  + +  I   +  +   L  + T+RAF  +   E  +   L
Sbjct: 285  TPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAEL 344

Query: 1083 NLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMST 1142
                         +  FQ    + F    +   FI        +   G +++  +   + 
Sbjct: 345  EACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTV 404

Query: 1143 LQWAVNSSIDVDSLMRSVS---RVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVK 1199
             +   N S+    ++R +S   RVF+++ +           P   G            V 
Sbjct: 405  QRSMANLSVLFGQVVRGLSAGARVFEYMAL-------NPCIPLSGGCC----------VP 447

Query: 1200 KDDIWPSGGQMTVKDLTAKYT-EGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL 1258
            K+ +    G +T +++   Y    G  +L++ + ++ PG+ V L+G++G GK+T+ S   
Sbjct: 448  KEQL---RGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLE 504

Query: 1259 RLLN-TEGEIQIDGVSWDSITLQQWR-KAFGVIPQKVFIFSGTFRKNLDPYE-QWSDQEI 1315
            R  + T G + +DG    ++     R +  G I Q+  +F  T  +N+   + + SD+E+
Sbjct: 505  RFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEV 564

Query: 1316 WKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAH 1375
            +  A E      I  FP   + V+ + G  LS G KQ + +AR+++ +  +L+LDE ++ 
Sbjct: 565  YTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSA 624

Query: 1376 LDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
            LD  + ++++  L +A A  TV++  HR+  +      +V+ + +V +  + ++LL +  
Sbjct: 625  LDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGG 684

Query: 1436 LFRQAISPSDRVKLFPHRNSSKCKSKPQ 1463
            L+ + I    R  L   R ++    KP+
Sbjct: 685  LYAELIR---RQALDAPRTAAPPPKKPE 709


>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
            sapiens]
          Length = 753

 Score =  115 bits (289), Expect = 2e-25
 Identities = 108/436 (24%), Positives = 193/436 (44%), Gaps = 45/436 (10%)

Query: 1056 VTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT 1115
            + SL    T++ F  + Y    +   L  +        STL         IF +   A+ 
Sbjct: 335  IDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIM 394

Query: 1116 FIS-------ILTTGEGEGRVGII--LTLAMNIMSTLQWAVNSS-IDVDSLMRSVSRVFK 1165
             ++        LT G+     G++  L+L +N + T+      + ID+++L       F 
Sbjct: 395  VLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTL-------FT 447

Query: 1166 FIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNA 1225
             + + T+ K      P +    +  +  +N H +                   Y EG   
Sbjct: 448  LLKVDTQIKDKVMASPLQITPQTATVAFDNVHFE-------------------YIEG-QK 487

Query: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDSITLQQWRK 1284
            +L  ISF +  G++V ++G +GSGKST++    R    + G I + G +   ++L+  R+
Sbjct: 488  VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRR 547

Query: 1285 AFGVIPQKVFIFSGTFRKNLDPYE-QWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
            A GV+PQ   +F  T   NL       S +E++ VA   GL   I + P   D  + + G
Sbjct: 548  AVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERG 607

Query: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
              LS G KQ + +AR++L    ++L DE ++ LD +T + I   +K      T I   HR
Sbjct: 608  LKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHR 667

Query: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLL-NERSLFRQA-ISPSDRVKLFPHRNSSKCKSK 1461
            +  +++  + +V+++ KV +  +   LL N  S++ +   + S RV+   H N      K
Sbjct: 668  LSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQ--NHDNPKWEAKK 725

Query: 1462 PQIAALKEETEEEVQD 1477
              I+  KEE  +++Q+
Sbjct: 726  ENIS--KEEERKKLQE 739



 Score = 88.2 bits (217), Expect = 5e-17
 Identities = 55/207 (26%), Positives = 107/207 (51%), Gaps = 15/207 (7%)

Query: 437 GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR--------- 487
           G  VL  I+F++  G+ +A+ G +G+GK++++ ++    EP +G I  +G+         
Sbjct: 485 GQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLES 544

Query: 488 ----ISFCSQFSWIMPGTIKENIIFG-VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLG 542
               +    Q + +   TI  N+++G +S       +V K   L + I +     +  +G
Sbjct: 545 LRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVG 604

Query: 543 EGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRIL 602
           E G+ LSGG++ R+++ARA+ KD  + L D     LD +TE+ I    +  ++ ++T I 
Sbjct: 605 ERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETIL-GAMKDVVKHRTSIF 663

Query: 603 VTSKMEHLKKADKILILHEGSSYFYGT 629
           +  ++  +  AD+I++L +G     GT
Sbjct: 664 IAHRLSTVVDADEIIVLDQGKVAERGT 690


>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
            sapiens]
          Length = 1280

 Score =  111 bits (277), Expect = 6e-24
 Identities = 130/625 (20%), Positives = 272/625 (43%), Gaps = 62/625 (9%)

Query: 838  ESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTH 897
            ESIP V+ W      +T     +  +   ++    + A +++   ++G     D   +  
Sbjct: 690  ESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKR 749

Query: 898  SRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVL 957
              +N ++++          ++ +G+   +    F +G         ++K L + +  S+L
Sbjct: 750  QNSNLFSLL----------FLALGIISFITF--FLQGFTFGKAGEILTKRLRYMVFRSML 797

Query: 958  QAPMSTLNTLK--AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPY- 1014
            +  +S  +  K   G +  R + D A +   +   +    Q +   +G   +++ +  + 
Sbjct: 798  RQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIAN-LGTGIIISFIYGWQ 856

Query: 1015 ---IFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQ 1071
               + +A VP+I    ++    L       + E EG   I T  + + +   T+ +  ++
Sbjct: 857  LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFR---TVVSLTQE 913

Query: 1072 PYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGI 1131
              FE ++ ++L +   N            +R   IF I F + T   +  +  G  R G 
Sbjct: 914  QKFEHMYAQSLQVPYRN-----------SLRKAHIFGITF-SFTQAMMYFSYAGCFRFGA 961

Query: 1132 ILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSK-- 1189
             L +A  +MS            D L+   + VF  + +   G+ +     Y   ++S   
Sbjct: 962  YL-VAHKLMSF----------EDVLLVFSAVVFGAMAV---GQVSSFAPDYAKAKISAAH 1007

Query: 1190 -VMIIENSHV----KKDDIWPSG--GQMTVKDLTAKY-TEGGNAILENISFSISPGQRVG 1241
             +MIIE + +      + + P+   G +T  ++   Y T     +L+ +S  +  GQ + 
Sbjct: 1008 IIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA 1067

Query: 1242 LLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTF 1300
            L+G +G GKST++    R  +   G++ +DG     + +Q  R   G++ Q+  +F  + 
Sbjct: 1068 LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSI 1127

Query: 1301 RKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLA 1357
             +N+   D     S +EI + A E  + + IE  P K    + D G  LS G KQ + +A
Sbjct: 1128 AENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIA 1187

Query: 1358 RSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIE 1417
            R+++ +  ILLLDE ++ LD  + ++++  L +A    T I+  HR+  +      +V +
Sbjct: 1188 RALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQ 1247

Query: 1418 ENKVRQYDSIQKLLNERSLFRQAIS 1442
              +V+++ + Q+LL ++ ++   +S
Sbjct: 1248 NGRVKEHGTHQQLLAQKGIYFSMVS 1272



 Score =  100 bits (250), Expect = 8e-21
 Identities = 67/250 (26%), Positives = 127/250 (50%), Gaps = 3/250 (1%)

Query: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRK 1284
            IL+ ++  +  GQ V L+G +G GKST +    RL + TEG + +DG    +I ++  R+
Sbjct: 409  ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLRE 468

Query: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
              GV+ Q+  +F+ T  +N+    E  +  EI K   E      I + P K D ++ + G
Sbjct: 469  IIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERG 528

Query: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
              LS G KQ + +AR+++   KILLLDE ++ LD  +  +++  L +A    T I+  HR
Sbjct: 529  AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHR 588

Query: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQ 1463
            +  +         ++  + +  +  +L+ E+ ++ + ++           N++  +SK +
Sbjct: 589  LSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAAD-ESKSE 647

Query: 1464 IAALKEETEE 1473
            I AL+  + +
Sbjct: 648  IDALEMSSND 657



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 120/563 (21%), Positives = 246/563 (43%), Gaps = 86/563 (15%)

Query: 173 DKISIGQLVSLLSNNLNKFDEGLALA---HFVWIAPLQVALLMGLI--WELLQASAFCGL 227
           D   +G+L + L+++++K +EG+       F  +A      ++G    W+L        L
Sbjct: 164 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVI----L 219

Query: 228 GFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEA-MEKMIE 286
               VL L  A   +++  + D+     ++   +  E++  I++V A+  ++  +E+  +
Sbjct: 220 AISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNK 279

Query: 287 NLRQTELKLTRKAAYVRYFNSSAFF--FSGFFVVFLSVLPYALIKGIILRKIFTTISFCI 344
           NL + +    +KA        +AF   ++ + + F       L     + ++ T     +
Sbjct: 280 NLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVL 339

Query: 345 VLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEG 404
           +   +V +  P +++ + ++ GA  +I        +K           +++N  +     
Sbjct: 340 IGAFSVGQASP-SIEAFANARGAAYEI--------FK-----------IIDNKPSI---- 375

Query: 405 FGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGK 464
             + + K+    +N K +    ++ FS  S     +LK +N K++ GQ +A+ G++G GK
Sbjct: 376 --DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGK 433

Query: 465 TSLLMVIMGELEPSEGKIKHSGR-------------ISFCSQFSWIMPGTIKENIIFG-- 509
           ++ + ++    +P+EG +   G+             I   SQ   +   TI ENI +G  
Sbjct: 434 STTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRE 493

Query: 510 -VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADL 568
            V+ DE      +K     + I K   K + ++GE G  LSGGQ+ RI++ARA+ ++  +
Sbjct: 494 NVTMDEIE--KAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKI 551

Query: 569 YLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKIL----------- 617
            LLD     LD  +E  + +  + K    +T I++  ++  ++ AD I            
Sbjct: 552 LLLDEATSALDTESE-AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKG 610

Query: 618 ----ILHEGSSYF-------YGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETL 666
               ++ E   YF        G   EL+N   +  S++   D+ +  S + R+S++ +  
Sbjct: 611 NHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEI---DALEMSSNDSRSSLIRKRS 667

Query: 667 HRFSLEGDAPVSWTETKKQSFKQ 689
            R S+ G    S  + +K S K+
Sbjct: 668 TRRSVRG----SQAQDRKLSTKE 686



 Score = 97.1 bits (240), Expect = 1e-19
 Identities = 146/663 (22%), Positives = 282/663 (42%), Gaps = 116/663 (17%)

Query: 36   DIYQIPSVDSADNLSEKLE--------REWDRELASKKNPKLINALRRCFFWRFM----- 82
            D  ++ S DS  +L  K          +  DR+L++K+   L  ++    FWR M     
Sbjct: 649  DALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE--ALDESIPPVSFWRIMKLNLT 706

Query: 83   ---FYGIFLYLGEVTKAVQP---LLLGRIIASY----DPDNKEERS---IAIYLGIGLCL 129
               ++ + ++   +   +QP   ++  +II  +    DP+ K + S     ++L +G+ +
Sbjct: 707  EWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGI-I 765

Query: 130  LFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLD--KISIGQLVSLLSNN 187
             FI  T  L    FG    G  +   +  ++++  L+      D  K + G L + L+N+
Sbjct: 766  SFI--TFFLQGFTFG--KAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAND 821

Query: 188  LNKFDEGLALAHFVW---IAPLQVALLMGLI--WELLQASAFCGLGFLIVLALFQAGLGR 242
              +    +     V    IA L   +++  I  W+L           L+ +    A  G 
Sbjct: 822  AAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTL--------LLLAIVPIIAIAGV 873

Query: 243  MMMKYRDQRAGKISERLV----ITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
            + MK    +A K  + L     I +E IEN ++V +   E+  E M     Q   + + +
Sbjct: 874  VEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLR 933

Query: 299  AAYV-----------RYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLR 347
             A++            YF+ +  F  G ++V   ++ +   + ++L  +F+ + F  +  
Sbjct: 934  KAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSF---EDVLL--VFSAVVFGAMAV 988

Query: 348  MAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGE 407
              V+   P   +    +   I  I+        KT   +  +TE +M N T      FGE
Sbjct: 989  GQVSSFAPDYAKAKISAAHIIMIIE--------KTPLIDSYSTEGLMPN-TLEGNVTFGE 1039

Query: 408  LFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSL 467
            +                     F+  +    PVL+ ++ ++++GQ LA+ GS+G GK+++
Sbjct: 1040 VV--------------------FNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1079

Query: 468  LMVIMGELEPSEGKIKHSGR-------------ISFCSQFSWIMPGTIKENIIFGVSYDE 514
            + ++    +P  GK+   G+             +   SQ   +   +I ENI +G +   
Sbjct: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139

Query: 515  YRYRSVIKACQLEEDISKFAE----KDNIVLGEGGITLSGGQRARISLARAVYKDADLYL 570
                 +++A + E +I  F E    K +  +G+ G  LSGGQ+ RI++ARA+ +   + L
Sbjct: 1140 VSQEEIVRAAK-EANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILL 1198

Query: 571  LDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTF 630
            LD     LD  +EK + +  + K    +T I++  ++  ++ AD I++   G    +GT 
Sbjct: 1199 LDEATSALDTESEK-VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1257

Query: 631  SEL 633
             +L
Sbjct: 1258 QQL 1260


>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
            sapiens]
          Length = 842

 Score =  108 bits (271), Expect = 3e-23
 Identities = 101/478 (21%), Positives = 199/478 (41%), Gaps = 32/478 (6%)

Query: 968  KAGGILNRFSKDIAILDDLLPLTIFDFIQLLL-IVIGAIAVVAVLQPYIFVATVPVIVAF 1026
            + G +L    +  + +  LL   +F+ I  L  I+IG I        +  +     +  +
Sbjct: 365  RTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLY 424

Query: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHT 1086
            + L     +   + ++  +   +      V SL    T++ +  + Y    + +A+  + 
Sbjct: 425  LTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQ 484

Query: 1087 ANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVG---IILTLAMNIMSTL 1143
               +   ++L        ++  +  +A + +      E + +VG   +  T  + +   L
Sbjct: 485  GLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPL 544

Query: 1144 QWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKP--YKNGQLSKVMIIENSHVKKD 1201
             W       + +    +  +F  +   TE K      P  ++ G++      EN H    
Sbjct: 545  NWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIE----FENVHFSYA 600

Query: 1202 DIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261
            D                    G   L+++SF++ PGQ + L+G +G+GKST+L    R  
Sbjct: 601  D--------------------GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFY 640

Query: 1262 N-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWS-DQEIWKVA 1319
            + + G I+IDG     +T    R   GV+PQ   +F+ T   N+      + + E+   A
Sbjct: 641  DISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAA 700

Query: 1320 DEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV 1379
               G+   I  FP      + + G  LS G KQ + +AR++L    I+LLDE ++ LD  
Sbjct: 701  QAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTS 760

Query: 1380 TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
              + I+ +L +  A+ T I+  HR+  ++   Q LVI++  + +    + LL+   ++
Sbjct: 761  NERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818



 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 59/200 (29%), Positives = 105/200 (52%), Gaps = 15/200 (7%)

Query: 437 GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR--------- 487
           G   L+D++F +  GQ LA+ G +GAGK+++L ++    + S G I+  G+         
Sbjct: 602 GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQAS 661

Query: 488 ----ISFCSQFSWIMPGTIKENIIFG-VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLG 542
               I    Q + +   TI +NI +G V+       +  +A  + + I  F E     +G
Sbjct: 662 LRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVG 721

Query: 543 EGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRIL 602
           E G+ LSGG++ R+++AR + K   + LLD     LD   E+ I ++ + K+ AN+T I+
Sbjct: 722 ERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI-QASLAKVCANRTTIV 780

Query: 603 VTSKMEHLKKADKILILHEG 622
           V  ++  +  AD+IL++ +G
Sbjct: 781 VAHRLSTVVNADQILVIKDG 800


>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
            sapiens]
          Length = 812

 Score =  107 bits (268), Expect = 7e-23
 Identities = 65/221 (29%), Positives = 117/221 (52%), Gaps = 4/221 (1%)

Query: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRK 1284
            IL  +S SI  G+ V  +G +G GKST +    RL +  +G++  DGV    + +Q  R 
Sbjct: 587  ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646

Query: 1285 AFGVIPQKVFIFSGTFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVD 1341
               ++PQ+  +F+ +  +N+   D        EI + A+   + S IE  P K +  +  
Sbjct: 647  QIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL 706

Query: 1342 GGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCE 1401
             G  LS G KQ + +AR++L K KILLLDE ++ LD  + ++++  L +A    T ++  
Sbjct: 707  KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVT 766

Query: 1402 HRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAIS 1442
            HR+ A+      +V+   K+++  + Q+LL  R ++ + ++
Sbjct: 767  HRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVN 807



 Score = 97.8 bits (242), Expect = 7e-20
 Identities = 97/399 (24%), Positives = 170/399 (42%), Gaps = 60/399 (15%)

Query: 261 ITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFL 320
           I +E +ENI+++ +   E+A E+M E + QT+ + T K A +     S + FS  F+ F 
Sbjct: 431 IATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQII---GSCYAFSHAFIYFA 487

Query: 321 SVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY 380
               +     +I     T     IV                  + GA+   +  +   EY
Sbjct: 488 YAAGFRFGAYLIQAGRMTPEGMFIVFTAI--------------AYGAMAIGETLVLAPEY 533

Query: 381 KTLEYNLTTTEVVME---NVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLL- 436
              +        ++E   N+ +  +EG              +K    + +L F   S   
Sbjct: 534 SKAKSGAAHLFALLEKKPNIDSRSQEG--------------KKPDTCEGNLEFREVSFFY 579

Query: 437 ----GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------ 486
                  +L+ ++  IERG+ +A  GS+G GK++ + ++    +P +G++   G      
Sbjct: 580 PCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKEL 639

Query: 487 -------RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFA 534
                  +I+   Q   +   +I ENI +G     V  DE +      A  +   I    
Sbjct: 640 NVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIK--EAANAANIHSFIEGLP 697

Query: 535 EKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKL 594
           EK N  +G  G  LSGGQ+ R+++ARA+ +   + LLD     LD  +EK + +  + K 
Sbjct: 698 EKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEK-VVQHALDKA 756

Query: 595 MANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
              +T ++VT ++  ++ AD I++LH G     GT  EL
Sbjct: 757 RTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQEL 795



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 40/171 (23%), Positives = 88/171 (51%), Gaps = 1/171 (0%)

Query: 1276 SITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
            ++ ++ +R   GV+ Q+  +F  T   N+    +  +D+E+ + A E      I +FP K
Sbjct: 9    ALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNK 68

Query: 1335 LDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFAD 1394
             + ++ + G  +S G KQ + +AR+++   KIL+LDE ++ LD  +   ++  L++A   
Sbjct: 69   FNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKG 128

Query: 1395 CTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSD 1445
             T I+  HR+  +      + +++  + +  +  +L+ +R L+   +   D
Sbjct: 129  RTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQD 179



 Score = 61.2 bits (147), Expect = 7e-09
 Identities = 48/163 (29%), Positives = 80/163 (49%), Gaps = 4/163 (2%)

Query: 488 ISFCSQFSWIMPGTIKENIIFGVS--YDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
           I   SQ   +   TI  NI +G     DE   R+  +A    + I +F  K N ++GE G
Sbjct: 19  IGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREA-NAYDFIMEFPNKFNTLVGEKG 77

Query: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
             +SGGQ+ RI++ARA+ ++  + +LD     LD    K   ++ + K    +T I+V  
Sbjct: 78  AQMSGGQKQRIAIARALVRNPKILILDEATSALD-SESKSAVQAALEKASKGRTTIVVAH 136

Query: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCD 648
           ++  ++ AD I+ L +G     G  +EL   +  + S +M  D
Sbjct: 137 RLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQD 179


>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
           sapiens]
          Length = 738

 Score =  107 bits (268), Expect = 7e-23
 Identities = 128/595 (21%), Positives = 241/595 (40%), Gaps = 67/595 (11%)

Query: 87  FLYLGEVTKAVQPLLLGRII-ASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGL 145
           FL +  V     P  LG+II   Y     +       L +GL  +F+         ++ +
Sbjct: 177 FLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLM 236

Query: 146 HHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNL--------NKFDEGLAL 197
              G ++   + + ++   L+      DK   G+L++ LS++             +GL  
Sbjct: 237 QTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLR- 295

Query: 198 AHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISE 257
                 A  Q ++ + +++ +    A   L  +  +++     GR + K        +++
Sbjct: 296 ------AGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQ 349

Query: 258 RLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFV 317
              +  E I N+++V+A+  E    +   +     ++L RK A+ R     A   SG  +
Sbjct: 350 ATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLI 409

Query: 318 VFLSVLPYALIKGIILRKI-----FTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQ 372
           V   +    L+ G     +     F   +F + + +     F          LGA  ++ 
Sbjct: 410 VLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSF---YSELMKGLGAGGRLW 466

Query: 373 DFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN 432
           + L++      E  L   E V+ N  +F     G L  K               ++ F+ 
Sbjct: 467 ELLER------EPKLPFNEGVILNEKSFQ----GALEFK---------------NVHFAY 501

Query: 433 FSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------ 486
            +    P+ +D +  I  G + A+ G +G+GK+++L +++   +P+ G I   G      
Sbjct: 502 PARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQL 561

Query: 487 -------RISFCSQFSWIMPGTIKENIIFGV----SYDEYRYRSVIKACQLEEDISKFAE 535
                  +I   SQ   +   +I ENI +G     S      + V +       I  F +
Sbjct: 562 NPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQ 621

Query: 536 KDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLM 595
             N V+GE G+ LSGGQ+ RI++ARA+ K+  + LLD     LD   E  + +  + +LM
Sbjct: 622 GFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENE-YLVQEALDRLM 680

Query: 596 ANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSF 650
             +T +++  ++  +K A+ + +L +G    YG   EL +       KLM   SF
Sbjct: 681 DGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSF 735



 Score =  105 bits (263), Expect = 2e-22
 Identities = 111/500 (22%), Positives = 212/500 (42%), Gaps = 39/500 (7%)

Query: 948  LHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAV 1007
            L   +  S+L+  ++  +  + G ++NR S D A+L   +   + D ++        I++
Sbjct: 247  LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISM 306

Query: 1008 VAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRA 1067
            +  + P +    + V+    ++   + +  ++L ++  +  +         +  + T+RA
Sbjct: 307  MFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRA 366

Query: 1068 FGRQ-----PYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
            FG++      Y   + H  + L     F          +   +I     ++V +   L  
Sbjct: 367  FGKEMTEIEKYASKVDH-VMQLARKEAFARAGFFGATGLSGNLIV----LSVLYKGGLLM 421

Query: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPT---EGKPTKST 1179
            G     VG        + S L +A    I +  L    S + K +       E    +  
Sbjct: 422  GSAHMTVG-------ELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPK 474

Query: 1180 KPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNA-ILENISFSISPGQ 1238
             P+  G    V++ E S           G +  K++   Y       I ++ S SI  G 
Sbjct: 475  LPFNEG----VILNEKSFQ---------GALEFKNVHFAYPARPEVPIFQDFSLSIPSGS 521

Query: 1239 RVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFS 1297
               L+G +GSGKST+LS  LRL +   G I +DG     +     R   G + Q+  +FS
Sbjct: 522  VTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFS 581

Query: 1298 GTFRKNL----DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQL 1353
             +  +N+    D     + +EI +VA+     + I  FP   + V+ + G +LS G KQ 
Sbjct: 582  CSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQR 641

Query: 1354 MCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQF 1413
            + +AR++L   KILLLDE ++ LD     +++  L +     TV++  HR+  +      
Sbjct: 642  IAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMV 701

Query: 1414 LVIEENKVRQYDSIQKLLNE 1433
             V+++ K+ +Y   ++LL++
Sbjct: 702  AVLDQGKITEYGKHEELLSK 721


>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
           [Homo sapiens]
          Length = 1286

 Score =  105 bits (262), Expect = 3e-22
 Identities = 111/486 (22%), Positives = 210/486 (43%), Gaps = 71/486 (14%)

Query: 179 QLVSLLSNNLNKFDEGLALA---HFVWIAPLQVALLMGLI--WELLQASAFCGLGFLIVL 233
           +L + L+++++K  EG+       F  +A      ++G I  W+L        +    +L
Sbjct: 172 ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVI----MAISPIL 227

Query: 234 ALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWE----EAMEKMIENLR 289
            L  A   +++  + D+     ++   +  E +  I++V A+  +    E  +K +EN +
Sbjct: 228 GLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK 287

Query: 290 QTELKLTRKAAYVRYFNSSAFFFSGFFVVFLS-VLPYALIKGIILRKIFT-----TISFC 343
           +  +K        +  +++      F +++ S  L +     +++ K +T     T+ F 
Sbjct: 288 EIGIK--------KAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFS 339

Query: 344 IVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEE 403
           I++      Q    +  + ++ GA   I D +                     + +F E 
Sbjct: 340 ILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNP----------------KIDSFSER 383

Query: 404 GFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAG 463
           G      K     N+         + FS  S     +LK +N K++ GQ +A+ GS+G G
Sbjct: 384 GHKPDSIKGNLEFND---------VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCG 434

Query: 464 KTSLLMVIMGELEPSEGKIKHSGR-------------ISFCSQFSWIMPGTIKENIIFG- 509
           K++ + +I    +P EG I   G+             I   SQ   +   TI ENI +G 
Sbjct: 435 KSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGR 494

Query: 510 --VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDAD 567
             V+ DE +    +K     E I K  +K + ++GE G  LSGGQ+ RI++ARA+ ++  
Sbjct: 495 GNVTMDEIK--KAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPK 552

Query: 568 LYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFY 627
           + LLD     LD  +E E+ ++ + K    +T I++  ++  ++ AD I    +G     
Sbjct: 553 ILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQ 611

Query: 628 GTFSEL 633
           G+ SEL
Sbjct: 612 GSHSEL 617



 Score = 98.6 bits (244), Expect = 4e-20
 Identities = 63/247 (25%), Positives = 120/247 (48%), Gaps = 12/247 (4%)

Query: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTE-- 1264
            G +T  ++   Y    N  +L+ +S  +  GQ + L+G +G GKST++    R  +    
Sbjct: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091

Query: 1265 ------GEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNL---DPYEQWSDQEI 1315
                  G   +DG     + +Q  R   G++ Q+  +F  +  +N+   D     S  EI
Sbjct: 1092 TVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI 1151

Query: 1316 WKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAH 1375
               A    +   IE  P K +  + D G  LS G KQ + +AR+++ + +ILLLDE ++ 
Sbjct: 1152 VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSA 1211

Query: 1376 LDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
            LD  + ++++  L +A    T I+  HR+  +      +V +  +V+++ + Q+LL ++ 
Sbjct: 1212 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1271

Query: 1436 LFRQAIS 1442
            ++   +S
Sbjct: 1272 IYFSMVS 1278



 Score = 96.3 bits (238), Expect = 2e-19
 Identities = 66/238 (27%), Positives = 114/238 (47%), Gaps = 3/238 (1%)

Query: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
            G +   D+   Y    N  IL+ ++  +  GQ V L+G +G GKST +    RL +  EG
Sbjct: 392  GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451

Query: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYE-QWSDQEIWKVADEVGL 1324
             I IDG    +  +   R+  GV+ Q+  +FS T  +N+       +  EI K   E   
Sbjct: 452  TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511

Query: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
               I + P K D ++ + G  LS G KQ + +AR+++   KILLLDE ++ LD  +   +
Sbjct: 512  YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571

Query: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAIS 1442
            +  L +A    T I+  HR+  +         E+  + +  S  +L+ +  ++ + ++
Sbjct: 572  QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVN 629



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 59/220 (26%), Positives = 105/220 (47%), Gaps = 28/220 (12%)

Query: 439  PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS------------- 485
            PVL+ ++ ++++GQ LA+ GS+G GK++++ ++    +P  G +                
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109

Query: 486  -------GRISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKF 533
                    ++   SQ   +   +I ENI +G     VS DE    S  KA  +   I   
Sbjct: 1110 LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIV--SAAKAANIHPFIETL 1167

Query: 534  AEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK 593
              K    +G+ G  LSGGQ+ RI++ARA+ +   + LLD     LD  +EK + +  + K
Sbjct: 1168 PHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDK 1226

Query: 594  LMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
                +T I++  ++  ++ AD I++   G    +GT  +L
Sbjct: 1227 AREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL 1266


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.400 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,836,463
Number of Sequences: 37866
Number of extensions: 2081522
Number of successful extensions: 5920
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 5293
Number of HSP's gapped (non-prelim): 367
length of query: 1480
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1365
effective length of database: 13,892,928
effective search space: 18963846720
effective search space used: 18963846720
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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