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Search of human proteins with 90421313
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
(1480 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 2908 0.0
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 414 e-115
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 414 e-115
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 298 2e-80
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 287 5e-77
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 285 3e-76
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 285 3e-76
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 285 3e-76
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 280 7e-75
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 280 1e-74
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 279 1e-74
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 279 1e-74
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 279 2e-74
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 276 1e-73
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 276 1e-73
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 276 1e-73
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 276 1e-73
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 266 1e-70
gi|134142335 ATP-binding cassette, sub-family C, member 1 isofor... 259 1e-68
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 252 2e-66
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 252 2e-66
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 250 6e-66
gi|221316556 ATP-binding cassette, sub-family C, member 3 isofor... 117 8e-26
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 115 2e-25
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 115 2e-25
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 111 6e-24
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 108 3e-23
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 107 7e-23
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 107 7e-23
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 105 3e-22
>gi|90421313 cystic fibrosis transmembrane conductance regulator [Homo
sapiens]
Length = 1480
Score = 2908 bits (7538), Expect = 0.0
Identities = 1480/1480 (100%), Positives = 1480/1480 (100%)
Query: 1 MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE 60
MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE
Sbjct: 1 MQRSPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE 60
Query: 61 LASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA 120
LASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA
Sbjct: 61 LASKKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA 120
Query: 121 IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL 180
IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL
Sbjct: 121 IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL 180
Query: 181 VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL 240
VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL
Sbjct: 181 VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL 240
Query: 241 GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA 300
GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA
Sbjct: 241 GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAA 300
Query: 301 YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQT 360
YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQT
Sbjct: 301 YVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQT 360
Query: 361 WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRK 420
WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRK
Sbjct: 361 WYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRK 420
Query: 421 TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG 480
TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG
Sbjct: 421 TSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEG 480
Query: 481 KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV
Sbjct: 481 KIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIV 540
Query: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR
Sbjct: 541 LGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTR 600
Query: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNS 660
ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNS
Sbjct: 601 ILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNS 660
Query: 661 ILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ 720
ILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ
Sbjct: 661 ILTETLHRFSLEGDAPVSWTETKKQSFKQTGEFGEKRKNSILNPINSIRKFSIVQKTPLQ 720
Query: 721 MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG 780
MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG
Sbjct: 721 MNGIEEDSDEPLERRLSLVPDSEQGEAILPRISVISTGPTLQARRRQSVLNLMTHSVNQG 780
Query: 781 QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESI 840
QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESI
Sbjct: 781 QNIHRKTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESI 840
Query: 841 PAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN 900
PAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN
Sbjct: 841 PAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN 900
Query: 901 NSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP 960
NSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP
Sbjct: 901 NSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAP 960
Query: 961 MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATV 1020
MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATV
Sbjct: 961 MSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATV 1020
Query: 1021 PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHK 1080
PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHK
Sbjct: 1021 PVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHK 1080
Query: 1081 ALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIM 1140
ALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIM
Sbjct: 1081 ALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIM 1140
Query: 1141 STLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK 1200
STLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK
Sbjct: 1141 STLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKK 1200
Query: 1201 DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL 1260
DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL
Sbjct: 1201 DDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL 1260
Query: 1261 LNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD 1320
LNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD
Sbjct: 1261 LNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD 1320
Query: 1321 EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380
EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT
Sbjct: 1321 EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380
Query: 1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA 1440
YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA
Sbjct: 1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQA 1440
Query: 1441 ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL 1480
ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL
Sbjct: 1441 ISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQDTRL 1480
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 414 bits (1063), Expect = e-115
Identities = 224/652 (34%), Positives = 368/652 (56%), Gaps = 42/652 (6%)
Query: 4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
+PL+ A++ S++FF W P+ + G+++RLE D+Y + D + +L E+L+ WD+E+
Sbjct: 11 NPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLR 70
Query: 64 KKN----PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRII---ASYDPDNKEE 116
+N P L A+ +C++ ++ GIF + E K +QP+ LG+II +YDP +
Sbjct: 71 AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVA 130
Query: 117 RSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKIS 176
+ A L ++ +L H + + GM++R+AM +IY+K L+LS+ + K +
Sbjct: 131 LNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTT 190
Query: 177 IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALF 236
GQ+V+LLSN++NKFD+ HF+W PLQ + L+W + S G+ LI+L
Sbjct: 191 TGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPL 250
Query: 237 QAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLT 296
Q+ G++ R + A R+ +E+I I+ +K Y WE++ +I NLR+ E+
Sbjct: 251 QSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKI 310
Query: 297 RKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILR-KIFTTISFCIVLRMAVTRQFP 355
+++ +R N ++FF + +VF++ Y L+ +I ++F ++ +R+ VT FP
Sbjct: 311 LRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFP 370
Query: 356 WAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENV---TAFWEEGFGELFEKA 412
A++ +++ +I +IQ FL E L + M +V TAFW+ KA
Sbjct: 371 SAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD--------KA 422
Query: 413 KQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIM 472
+ TP L+ ++F + G+LLAV G GAGK+SLL ++
Sbjct: 423 SE-----------------------TPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL 459
Query: 473 GELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISK 532
GEL PS G + GRI++ SQ W+ GT++ NI+FG Y++ RY VIKAC L++D+
Sbjct: 460 GELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL 519
Query: 533 FAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVC 592
+ D V+G+ G TLSGGQ+AR++LARAVY+DAD+YLLD P +D + +FE C+C
Sbjct: 520 LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCIC 579
Query: 593 KLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKL 644
+++ K ILVT ++++LK A +ILIL +G GT++E DF S L
Sbjct: 580 QILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631
Score = 90.1 bits (222), Expect = 1e-17
Identities = 114/497 (22%), Positives = 209/497 (42%), Gaps = 62/497 (12%)
Query: 950 HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
H + L+ + G I+N S D+ D + F L + AIAV A
Sbjct: 172 HMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHF----LWAGPLQAIAVTA 227
Query: 1010 VLQPYIFV---ATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLR 1066
+L I + A + V++ + L++ F + L+ + + + G+ ++
Sbjct: 228 LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287
Query: 1067 AFGRQPYFETLFHKALNLHTANWFLYLSTLR------WFQMRIEMIFVIFFIAVTFISIL 1120
+ + F L L + L S LR +F ++FV F V S++
Sbjct: 288 MYAWEKSFSNLITN-LRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVI 346
Query: 1121 TTGEGEGRVGIILTLAMNIMSTLQWAVNSSID-VDSLMRSVSRVFKFIDMPTEGKPTKST 1179
T RV + +TL + T+ S+I+ V + S+ R+ F+ + +
Sbjct: 347 TAS----RVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQ----- 397
Query: 1180 KPYKNGQLSKVMIIENSHVKKDDIWPSGGQ--MTVKDLTAKYTEGGNA-ILENISFSISP 1236
+N QL PS G+ + V+D TA + + L+ +SF++ P
Sbjct: 398 ---RNRQL-----------------PSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRP 437
Query: 1237 GQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFI 1295
G+ + ++G G+GKS+LLSA L L + G + + G + Q+ ++
Sbjct: 438 GELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWV 484
Query: 1296 FSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMC 1355
FSGT R N+ +++ + KV L+ ++ V+ D G LS G K +
Sbjct: 485 FSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVN 544
Query: 1356 LARSVLSKAKILLLDEPSAHLD-PVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL 1414
LAR+V A I LLD+P + +D V+ + + Q + IL H+++ + Q L
Sbjct: 545 LARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQIL 604
Query: 1415 VIEENKVRQYDSIQKLL 1431
++++ K+ Q + + L
Sbjct: 605 ILKDGKMVQKGTYTEFL 621
Score = 74.7 bits (182), Expect = 6e-13
Identities = 48/135 (35%), Positives = 67/135 (49%), Gaps = 3/135 (2%)
Query: 865 WCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN---NSYAVIITSTSSYYVFYIYVG 921
W + IFL + + V ++L + L N N N + + IY G
Sbjct: 711 WIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSG 770
Query: 922 VADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIA 981
+ + G R L + + L+ S+ LH+KM S+L+AP+ + G ILNRFSKDI
Sbjct: 771 LTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIG 830
Query: 982 ILDDLLPLTIFDFIQ 996
LDDLLPLT DFIQ
Sbjct: 831 HLDDLLPLTFLDFIQ 845
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 414 bits (1063), Expect = e-115
Identities = 224/652 (34%), Positives = 368/652 (56%), Gaps = 42/652 (6%)
Query: 4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
+PL+ A++ S++FF W P+ + G+++RLE D+Y + D + +L E+L+ WD+E+
Sbjct: 11 NPLQDANLCSRVFFWWLNPLFKIGHKRRLEEDDMYSVLPEDRSQHLGEELQGFWDKEVLR 70
Query: 64 KKN----PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRII---ASYDPDNKEE 116
+N P L A+ +C++ ++ GIF + E K +QP+ LG+II +YDP +
Sbjct: 71 AENDAQKPSLTRAIIKCYWKSYLVLGIFTLIEESAKVIQPIFLGKIINYFENYDPMDSVA 130
Query: 117 RSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKIS 176
+ A L ++ +L H + + GM++R+AM +IY+K L+LS+ + K +
Sbjct: 131 LNTAYAYATVLTFCTLILAILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTT 190
Query: 177 IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALF 236
GQ+V+LLSN++NKFD+ HF+W PLQ + L+W + S G+ LI+L
Sbjct: 191 TGQIVNLLSNDVNKFDQVTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPL 250
Query: 237 QAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLT 296
Q+ G++ R + A R+ +E+I I+ +K Y WE++ +I NLR+ E+
Sbjct: 251 QSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRKKEISKI 310
Query: 297 RKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILR-KIFTTISFCIVLRMAVTRQFP 355
+++ +R N ++FF + +VF++ Y L+ +I ++F ++ +R+ VT FP
Sbjct: 311 LRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVITASRVFVAVTLYGAVRLTVTLFFP 370
Query: 356 WAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENV---TAFWEEGFGELFEKA 412
A++ +++ +I +IQ FL E L + M +V TAFW+ KA
Sbjct: 371 SAIERVSEAIVSIRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWD--------KA 422
Query: 413 KQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIM 472
+ TP L+ ++F + G+LLAV G GAGK+SLL ++
Sbjct: 423 SE-----------------------TPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVL 459
Query: 473 GELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISK 532
GEL PS G + GRI++ SQ W+ GT++ NI+FG Y++ RY VIKAC L++D+
Sbjct: 460 GELAPSHGLVSVHGRIAYVSQQPWVFSGTLRSNILFGKKYEKERYEKVIKACALKKDLQL 519
Query: 533 FAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVC 592
+ D V+G+ G TLSGGQ+AR++LARAVY+DAD+YLLD P +D + +FE C+C
Sbjct: 520 LEDGDLTVIGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCIC 579
Query: 593 KLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKL 644
+++ K ILVT ++++LK A +ILIL +G GT++E DF S L
Sbjct: 580 QILHEKITILVTHQLQYLKAASQILILKDGKMVQKGTYTEFLKSGIDFGSLL 631
Score = 398 bits (1023), Expect = e-110
Identities = 216/582 (37%), Positives = 339/582 (58%), Gaps = 24/582 (4%)
Query: 865 WCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRN---NSYAVIITSTSSYYVFYIYVG 921
W + IFL + + V ++L + L N N N + + IY G
Sbjct: 711 WIVFIFLILLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWYLGIYSG 770
Query: 922 VADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIA 981
+ + G R L + + L+ S+ LH+KM S+L+AP+ + G ILNRFSKDI
Sbjct: 771 LTVATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFDRNPIGRILNRFSKDIG 830
Query: 982 ILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLK 1041
LDDLLPLT DFIQ LL V+G ++V + P+I + VP+ + FI LR YFL+TS+ +K
Sbjct: 831 HLDDLLPLTFLDFIQTLLQVVGVVSVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVK 890
Query: 1042 QLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQM 1101
+LES RSP+F+HL +SL+GLWT+RA+ + + LF +LH+ WFL+L+T RWF +
Sbjct: 891 RLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAV 950
Query: 1102 RIEMIFVIFFIAVTFIS-ILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSV 1160
R++ I +F I V F S IL G+VG+ L+ A+ +M QW V S +V+++M SV
Sbjct: 951 RLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISV 1010
Query: 1161 SRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYT 1220
RV ++ D+ E +P WP G + ++ Y+
Sbjct: 1011 ERVIEYTDLEKEAPWEYQKRP-------------------PPAWPHEGVIIFDNVNFMYS 1051
Query: 1221 EGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITLQ 1280
GG +L++++ I ++VG++GRTG+GKS+L+SA RL EG+I ID + I L
Sbjct: 1052 PGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWIDKILTTEIGLH 1111
Query: 1281 QWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLV 1340
RK +IPQ+ +F+GT RKNLDP+ + +D+E+W EV L+ IE PGK+D L
Sbjct: 1112 DLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELWNALQEVQLKETIEDLPGKMDTELA 1171
Query: 1341 DGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILC 1400
+ G S G +QL+CLAR++L K +IL++DE +A++DP T ++I++ +++ FA CTV+
Sbjct: 1172 ESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTI 1231
Query: 1401 EHRIEAMLECQQFLVIEENKVRQYDSIQKLL-NERSLFRQAI 1441
HR+ +++ + +V++ ++++YD LL N+ SLF + +
Sbjct: 1232 AHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
Score = 90.1 bits (222), Expect = 1e-17
Identities = 114/497 (22%), Positives = 209/497 (42%), Gaps = 62/497 (12%)
Query: 950 HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
H + L+ + G I+N S D+ D + F L + AIAV A
Sbjct: 172 HMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQVTVFLHF----LWAGPLQAIAVTA 227
Query: 1010 VLQPYIFV---ATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLR 1066
+L I + A + V++ + L++ F + L+ + + + G+ ++
Sbjct: 228 LLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARIRTMNEVITGIRIIK 287
Query: 1067 AFGRQPYFETLFHKALNLHTANWFLYLSTLR------WFQMRIEMIFVIFFIAVTFISIL 1120
+ + F L L + L S LR +F ++FV F V S++
Sbjct: 288 MYAWEKSFSNLITN-LRKKEISKILRSSCLRGMNLASFFSASKIIVFVTFTTYVLLGSVI 346
Query: 1121 TTGEGEGRVGIILTLAMNIMSTLQWAVNSSID-VDSLMRSVSRVFKFIDMPTEGKPTKST 1179
T RV + +TL + T+ S+I+ V + S+ R+ F+ + +
Sbjct: 347 TAS----RVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVSIRRIQTFLLLDEISQ----- 397
Query: 1180 KPYKNGQLSKVMIIENSHVKKDDIWPSGGQ--MTVKDLTAKYTEGGNA-ILENISFSISP 1236
+N QL PS G+ + V+D TA + + L+ +SF++ P
Sbjct: 398 ---RNRQL-----------------PSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRP 437
Query: 1237 GQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFI 1295
G+ + ++G G+GKS+LLSA L L + G + + G + Q+ ++
Sbjct: 438 GELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG-------------RIAYVSQQPWV 484
Query: 1296 FSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMC 1355
FSGT R N+ +++ + KV L+ ++ V+ D G LS G K +
Sbjct: 485 FSGTLRSNILFGKKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVN 544
Query: 1356 LARSVLSKAKILLLDEPSAHLD-PVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFL 1414
LAR+V A I LLD+P + +D V+ + + Q + IL H+++ + Q L
Sbjct: 545 LARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQIL 604
Query: 1415 VIEENKVRQYDSIQKLL 1431
++++ K+ Q + + L
Sbjct: 605 ILKDGKMVQKGTYTEFL 621
Score = 73.2 bits (178), Expect = 2e-12
Identities = 110/533 (20%), Positives = 222/533 (41%), Gaps = 76/533 (14%)
Query: 119 IAIYLGIGLC--LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKIS 176
+ IY G+ + L I R+LL+ ++ + + + +++ LK D+
Sbjct: 765 LGIYSGLTVATVLFGIARSLLVF-------YVLVNSSQTLHNKMFESILKAPVLFFDRNP 817
Query: 177 IGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALF 236
IG++++ S ++ D+ L L +I L ++G++ + + + L+ L +
Sbjct: 818 IGRILNRFSKDIGHLDDLLPLTFLDFIQTL--LQVVGVVSVAVAVIPWIAIP-LVPLGII 874
Query: 237 QAGLGRMMMKY-RDQRAGKISERLVITSEMIENIQ---SVKAYCWEEAMEKMIENLRQTE 292
L R ++ RD + + + R + S + ++Q +++AY EE +++ + +
Sbjct: 875 FIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLH 934
Query: 293 LKLTRKAAYVRYFNSSAFF------FSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVL 346
+ A+ + +S +F FV+ ++ L K + ++ +S+ + L
Sbjct: 935 SE-----AWFLFLTTSRWFAVRLDAICAMFVIIVAFGSLILAKTLDAGQVGLALSYALTL 989
Query: 347 RMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFG 406
F W V+ S N + + EY LE E A+ EG
Sbjct: 990 M----GMFQWCVR---QSAEVENMMISVERVIEYTDLEKE-APWEYQKRPPPAWPHEGV- 1040
Query: 407 ELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTP----VLKDINFKIERGQLLAVAGSTGA 462
+ F N + + +P VLK + I+ + + + G TGA
Sbjct: 1041 ---------------------IIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGA 1079
Query: 463 GKTSLLMVIMGELEPSEGKI-----------KHSGR--ISFCSQFSWIMPGTIKENIIFG 509
GK+SL+ + EP EGKI H R +S Q + GT+++N+
Sbjct: 1080 GKSSLISALFRLSEP-EGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPF 1138
Query: 510 VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLY 569
+ + + ++ QL+E I K + L E G S GQR + LARA+ + +
Sbjct: 1139 NEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQIL 1198
Query: 570 LLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEG 622
++D +D T+ E+ + + + A+ T + + ++ + +DKI++L G
Sbjct: 1199 IIDEATANVDPRTD-ELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSG 1250
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 298 bits (764), Expect = 2e-80
Identities = 175/595 (29%), Positives = 316/595 (53%), Gaps = 23/595 (3%)
Query: 846 WNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAV 905
W+ Y YI + L+ + +F+ V ++ W L Q GN+T +R N +V
Sbjct: 843 WSVYGVYIQAAGGPLAFLV-IMALFMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSV 901
Query: 906 IITSTSSYYVFY---IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMS 962
+ + ++ Y IY +L + RG+ V + S LH ++ +L++PM
Sbjct: 902 SDSMKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMK 961
Query: 963 TLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPV 1022
+T G ILNRFSKD+ +D LP FIQ +++V + ++A + P+ VA P+
Sbjct: 962 FFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVFPWFLVAVGPL 1021
Query: 1023 IVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKAL 1082
++ F +L ++LK+L++ +SP +H+ +S++GL T+ A+ + F + + L
Sbjct: 1022 VILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELL 1081
Query: 1083 NLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGE-GEGRVGIILTLAMNIMS 1141
+ + A +FL+ +RW +R+++I + + +L G+ G+ ++ A+ +
Sbjct: 1082 DDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTG 1141
Query: 1142 TLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKD 1201
Q+ V + + ++ SV R+ +I + P + I+N D
Sbjct: 1142 LFQFTVRLASETEARFTSVERINHYIKTLSLEAPAR---------------IKNKAPSPD 1186
Query: 1202 DIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261
WP G++T ++ +Y E +L+ +SF+I P +++G++GRTGSGKS+L A RL+
Sbjct: 1187 --WPQEGEVTFENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLV 1244
Query: 1262 NTEGE-IQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVAD 1320
G I+IDGV I L R +IPQ+ +FSGT R NLDP+ Q+++ +IW +
Sbjct: 1245 ELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALE 1304
Query: 1321 EVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVT 1380
++ I Q P KL+ +++ G S G +QL+C+AR++L KIL+LDE +A +D T
Sbjct: 1305 RTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTET 1364
Query: 1381 YQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
+I+ T+++AFADCT++ HR+ +L + +V+ + +V ++D+ LL+ S
Sbjct: 1365 DLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDS 1419
Score = 243 bits (621), Expect = 8e-64
Identities = 172/689 (24%), Positives = 333/689 (48%), Gaps = 60/689 (8%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQ-RLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
P++ A + S + FSW + R +++ L + D++ + +S+D +LER W EL +
Sbjct: 100 PVDNAGLFSCMTFSWLSSLARVAHKKGELSMEDVWSLSKHESSDVNCRRLERLWQEEL-N 158
Query: 64 KKNPKLINALRRCFFW---RFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA 120
+ P + R + + R + + L + ++ P + + + Y + +
Sbjct: 159 EVGPDAASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFMVKHLLEYTQATESNLQYS 218
Query: 121 IYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQL 180
+ L +GL L IVR+ L + G+++R A+ ++ +KK LKL + + + S+G+L
Sbjct: 219 LLLVLGLLLTEIVRSWSLALTWALNYRTGVRLRGAILTMAFKKILKLKN--IKEKSLGEL 276
Query: 181 VSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGL 240
+++ SN+ + E A+ + P V ++G+I+ ++ LG + + + A +
Sbjct: 277 INICSNDGQRMFEAAAVGSLLAGGP--VVAILGMIYNVIILGPTGFLGSAVFILFYPAMM 334
Query: 241 --GRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
R+ +R + ER+ +E++ I+ +K Y W +A + ++ +R+ E ++ K
Sbjct: 335 FASRLTAYFRRKCVAATDERVQKMNEVLTYIKFIKMYAWVKAFSQSVQKIREEERRILEK 394
Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK----GIILRKIFTTISFCIVLRMAVTRQF 354
A Y F S + VV SV+ +++ + + FT ++ + A+ +
Sbjct: 395 AGY---FQSITVGVAPIVVVIASVVTFSVHMTLGFDLTAAQAFTVVTVFNSMTFAL-KVT 450
Query: 355 PWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTT--EVVMENVTAFWEEGFGELF--- 409
P++V++ ++ A+++ + +E ++ + ++ M+N T W+ +
Sbjct: 451 PFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKPASPHIKIEMKNATLAWDSSHSSIQNSP 510
Query: 410 -----------------EKAKQ-------------------NNNNRKTSNGDDSLFFSNF 433
EK +Q +++ R + ++
Sbjct: 511 KLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLAEQKGHLLLDSDERPSPEEEEGKHIHLG 570
Query: 434 SLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQ 493
L L I+ +I+ G+L+ + GS G+GKTSL+ I+G++ EG I SG ++ +Q
Sbjct: 571 HLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFAYVAQ 630
Query: 494 FSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQR 553
+WI+ T+++NI+FG YDE RY SV+ +C L D++ D +GE G LSGGQR
Sbjct: 631 QAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQR 690
Query: 554 ARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKA 613
RISLARA+Y D +Y+LD P LD IF S + K + +KT + VT ++++L
Sbjct: 691 QRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDC 750
Query: 614 DKILILHEGSSYFYGTFSELQNLQPDFSS 642
D+++ + EG GT EL NL D+++
Sbjct: 751 DEVIFMKEGCITERGTHEELMNLNGDYAT 779
Score = 80.1 bits (196), Expect = 1e-14
Identities = 54/208 (25%), Positives = 103/208 (49%), Gaps = 15/208 (7%)
Query: 1227 LENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITLQQWRKA 1285
L +I I G+ VG+ G GSGK++L+SA L ++ EG I I G
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGT------------- 624
Query: 1286 FGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCV 1345
F + Q+ +I + T R N+ +++ ++ V + LR + P + + G
Sbjct: 625 FAYVAQQAWILNATLRDNILFGKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGAN 684
Query: 1346 LSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADCTVILCEHRI 1404
LS G +Q + LAR++ S I +LD+P + LD V I +++ TV+ H++
Sbjct: 685 LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQL 744
Query: 1405 EAMLECQQFLVIEENKVRQYDSIQKLLN 1432
+ +++C + + ++E + + + ++L+N
Sbjct: 745 QYLVDCDEVIFMKEGCITERGTHEELMN 772
Score = 69.3 bits (168), Expect = 3e-11
Identities = 55/224 (24%), Positives = 104/224 (46%), Gaps = 29/224 (12%)
Query: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
VLK ++F I+ + + + G TG+GK+SL M + +E S G IK G
Sbjct: 1209 VLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRS 1268
Query: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
++S Q + GT++ N+ Y E + ++ ++E I++ K + E G
Sbjct: 1269 KLSIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGD 1328
Query: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
S G+R + +ARA+ + + +LD +D T+ I E+ + + A+ T + + +
Sbjct: 1329 NFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQET-IREAFADCTMLTIAHR 1387
Query: 607 MEHLKKADKILILHEG---------------SSYFYGTFSELQN 635
+ + +D+I++L +G SS FY F+ +N
Sbjct: 1388 LHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAEN 1431
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 287 bits (735), Expect = 5e-77
Identities = 190/648 (29%), Positives = 327/648 (50%), Gaps = 45/648 (6%)
Query: 797 APQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTT---WNTYLRYI 853
A Q L + S+E ++ +E EE+ +E D+M ++ + T W T RY+
Sbjct: 927 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 986
Query: 854 TVHKSLIFVLIWCLVIFLAEVAASLVVL---WLLGNTPLQDKGNSTHSRNNSYAVIITST 910
T F+LI L+IF + S++V WL T S +S NN+ +
Sbjct: 987 T--SGGFFLLI--LMIFSKLLKHSVIVAIDYWLATWT-------SEYSINNTGK----AD 1031
Query: 911 SSYYV--FYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
+YYV F I G L + L + +T +K LHH +L+ ++ P+ +T
Sbjct: 1032 QTYYVAGFSILCGAGIFLCLV---TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTP 1088
Query: 969 AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
G ILNRFS D I+D +P T+ + L+ + AI +++ P VA +P+ VAF
Sbjct: 1089 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYF 1148
Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
++ YF S+ L++L+ + P+ H + +GL T+RAF + F+ + + +
Sbjct: 1149 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1208
Query: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVN 1148
+ + RW ++R + + + + SI + G VG+ L A+ I + L W V
Sbjct: 1209 YLFLSAANRWLEVRTDYLGACIVLTASIASI-SGSSNSGLVGLGLLYALTITNYLNWVVR 1267
Query: 1149 SSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGG 1208
+ D++ M +V +V F+ M +E G + + E+ WP G
Sbjct: 1268 NLADLEVQMGAVKKVNSFLTMESENY---------EGTMDPSQVPEH--------WPQEG 1310
Query: 1209 QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEI 1267
++ + DL +Y +L+++ I PGQ+VG+ GRTGSGKS+L AF R+++ +G+I
Sbjct: 1311 EIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKI 1370
Query: 1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSV 1327
IDG+ + L R +I Q +FSG+ R NLDP + +D +W+ + L+++
Sbjct: 1371 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNM 1430
Query: 1328 IEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387
++ PG LD V+ +GG S G +QL CLAR+ + K+ IL++DE +A +D T I+++
Sbjct: 1431 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1490
Query: 1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
+ AFAD TV+ HR+ +L +V++ + +YD+ + LL + +
Sbjct: 1491 VMTAFADRTVVTIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQEN 1538
Score = 213 bits (541), Expect = 1e-54
Identities = 177/686 (25%), Positives = 324/686 (47%), Gaps = 67/686 (9%)
Query: 10 SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
+++SK + W ++ +++ ++L I ++P +V + L + E E +++A
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYE-EQKKKVADHP 279
Query: 66 N--PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDP------------ 111
N P + A+ R F + F YL ++ PL + I+ +
Sbjct: 280 NRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGIS 339
Query: 112 ---DNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLS 168
+KE A L + L L I++ L + + G+ +R A+ ++IY K L+LS
Sbjct: 340 ETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLS 399
Query: 169 SRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG 226
+ L ++++GQ+ +L++ N+ L L +W P+Q+ + + L++ LL +SA G
Sbjct: 400 TSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVG 459
Query: 227 LGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIE 286
+++LA Q + + + + +ERL T+E+++ I+ +K Y WE K +E
Sbjct: 460 AAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVE 519
Query: 287 NLRQTELKLTRKAAYVRYFNSSAFFFSGFFV--VFLSVLPYALIKGIILR--KIFTTISF 342
R EL + + Y + S F + + V + + +A G L+ + F ++S
Sbjct: 520 ETRMKELSSLK--TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
Query: 343 CIVLRMAVTRQF--PWAVQTWYDSLGAINKIQDFLQKQE-----YKTLEYNLTTTEV--- 392
+L VT F V+ ++ ++ K+ +FL E ++T E +L
Sbjct: 578 FHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKH 634
Query: 393 --VMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN--FSL-LGTPVLKDINFK 447
V + G L + R D ++ +N FS G L +I+ +
Sbjct: 635 TGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIR 694
Query: 448 IERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-----------------RISF 490
I GQL + G G GK+SLL+ I+GE++ EGK+ S +++
Sbjct: 695 IPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAY 754
Query: 491 CSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSG 550
+Q W++ T++ENI FG +++ RY++V AC L+ DI D +GE GI LSG
Sbjct: 755 AAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSG 814
Query: 551 GQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMAN--KTRILVTSKME 608
GQR RI +ARA+Y++ ++ LD PF LD+ + + + K + + +T +LVT K++
Sbjct: 815 GQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQ 874
Query: 609 HLKKADKILILHEGSSYFYGTFSELQ 634
+L AD I+ + +GS GT ++Q
Sbjct: 875 YLTHADWIIAMKDGSVLREGTLKDIQ 900
Score = 82.0 bits (201), Expect = 4e-15
Identities = 84/384 (21%), Positives = 156/384 (40%), Gaps = 47/384 (12%)
Query: 263 SEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSV 322
SE E + +++A+ E ++ R EL T AY+ ++ + + +
Sbjct: 1176 SETAEGLTTIRAFRHETRFKQ-----RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230
Query: 323 LPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQE 379
+ A I I + ++ + +T W V+ D +GA+ K+ FL
Sbjct: 1231 VLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL---- 1286
Query: 380 YKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGT 438
T+E + V W +EG ++ + + NN K
Sbjct: 1287 --TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK------------------ 1326
Query: 439 PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------ 486
PVLK + I+ GQ + + G TG+GK+SL + ++ +GKI G
Sbjct: 1327 PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLR 1386
Query: 487 -RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
R+S Q + G+I+ N+ + R ++ QL+ + + V+ EGG
Sbjct: 1387 SRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1446
Query: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
S GQR LARA + + + ++D +D+ TE I + V A++T + +
Sbjct: 1447 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE-NILQKVVMTAFADRTVVTIAH 1505
Query: 606 KMEHLKKADKILILHEGSSYFYGT 629
++ + AD ++++ G+ Y T
Sbjct: 1506 RVHTILTADLVIVMKRGNILEYDT 1529
Score = 71.2 bits (173), Expect = 7e-12
Identities = 66/293 (22%), Positives = 129/293 (44%), Gaps = 28/293 (9%)
Query: 1213 KDLTAKYTEG------GNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
+D+ K T G G A L NI I GQ ++G+ G GKS+LL A L + T EG
Sbjct: 668 EDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEG 727
Query: 1266 EIQIDGVSWDSITLQQWRK----AFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADE 1321
++ V+ + + R + QK ++ + T +N+ ++ Q V D
Sbjct: 728 KVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDA 787
Query: 1322 VGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD-PVT 1380
L+ I+ P + + G LS G +Q +C+AR++ I+ LD+P + LD ++
Sbjct: 788 CSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLS 847
Query: 1381 YQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVRQ--------------Y 1424
+++ + + D T++L H+++ + + +++ V + Y
Sbjct: 848 DHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELY 907
Query: 1425 DSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQD 1477
+ + L+N + + +D+ L S+ A +++E EEE ++
Sbjct: 908 EHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 285 bits (728), Expect = 3e-76
Identities = 190/648 (29%), Positives = 327/648 (50%), Gaps = 45/648 (6%)
Query: 797 APQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTT---WNTYLRYI 853
A Q L + S+E ++ +E EE+ +E D+M ++ + T W T RY+
Sbjct: 891 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 950
Query: 854 TVHKSLIFVLIWCLVIFLAEVAASLVVL---WLLGNTPLQDKGNSTHSRNNSYAVIITST 910
T F+LI L+IF + S++V WL T S +S NN+ +
Sbjct: 951 T--SGGFFLLI--LMIFSKLLKHSVIVAIDYWLATWT-------SEYSINNTGK----AD 995
Query: 911 SSYYV--FYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
+YYV F I G L + L + +T +K LHH +L+ ++ P+ +T
Sbjct: 996 QTYYVAGFSILCGAGIFLCLV---TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTP 1052
Query: 969 AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
G ILNRFS D I+D +P T+ + L+ + AI +++ P VA +P+ VAF
Sbjct: 1053 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYF 1112
Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
++ YF S+ L++L+ + P+ H + +GL T+RAF + F+ + + +
Sbjct: 1113 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1172
Query: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVN 1148
+ + RW ++R + + + + SI + G VG+ L A+ I + L W V
Sbjct: 1173 YLFLSAANRWLEVRTDYLGACIVLTASIASI-SGSSNSGLVGLGLLYALTITNYLNWVVR 1231
Query: 1149 SSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGG 1208
+ D++ M +V +V F+ M +E G + + E+ WP G
Sbjct: 1232 NLADLEVQMGAVKKVNSFLTMESENY---------EGTMDPSQVPEH--------WPQEG 1274
Query: 1209 QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEI 1267
++ + DL +Y +L+++ I PGQ+VG+ GRTGSGKS+L AF R+++ +G+I
Sbjct: 1275 EIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKI 1334
Query: 1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSV 1327
IDG+ + L R +I Q +FSG+ R NLDP + +D +W+ + L+++
Sbjct: 1335 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNM 1394
Query: 1328 IEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387
++ PG LD V+ +GG S G +QL CLAR+ + K+ IL++DE +A +D T I+++
Sbjct: 1395 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1454
Query: 1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
+ AFAD TV+ HR+ ++++ LV E + + D++ LL ++
Sbjct: 1455 VMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKN 1502
Score = 216 bits (551), Expect = 1e-55
Identities = 178/674 (26%), Positives = 321/674 (47%), Gaps = 79/674 (11%)
Query: 10 SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
+++SK + W ++ +++ ++L I ++P +V + L + E E +++A
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYE-EQKKKVADHP 279
Query: 66 N--PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDP------------ 111
N P + A+ R F + F YL ++ PL + I+ +
Sbjct: 280 NRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGIS 339
Query: 112 ---DNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLS 168
+KE A L + L L I++ L + + G+ +R A+ ++IY K L+LS
Sbjct: 340 ETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLS 399
Query: 169 SRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG 226
+ L ++++GQ+ +L++ N+ L L +W P+Q+ + + L++ LL +SA G
Sbjct: 400 TSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVG 459
Query: 227 LGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIE 286
+++LA Q + + + + +ERL T+E+++ I+ +K Y WE K +E
Sbjct: 460 AAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVE 519
Query: 287 NLRQTELKLTRKAAYVRYFNSSAFFFSGFFV--VFLSVLPYALIKGIILR--KIFTTISF 342
R EL + + Y + S F + + V + + +A G L+ + F ++S
Sbjct: 520 ETRMKELSSLK--TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
Query: 343 CIVLRMAVTRQF--PWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAF 400
+L VT F V+ ++ ++ K+ +FL E
Sbjct: 578 FHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDS---------------- 618
Query: 401 WEEGFGEL-FEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGS 459
W G L FE K++ +NG +FS S L T L +I+ +I GQL + G
Sbjct: 619 WRTGESSLPFESCKKHTG--VVTNG----YFSWGSGLAT--LSNIDIRIPTGQLTMIVGQ 670
Query: 460 TGAGKTSLLMVIMGELEPSEGKIKHSG-----------------RISFCSQFSWIMPGTI 502
G GK+SLL+ I+GE++ EGK+ S +++ +Q W++ T+
Sbjct: 671 VGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATV 730
Query: 503 KENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAV 562
+ENI FG +++ RY++V AC L+ DI D +GE GI LSGGQR RI +ARA+
Sbjct: 731 EENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARAL 790
Query: 563 YKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMAN--KTRILVTSKMEHLKKADKILILH 620
Y++ ++ LD PF LD+ + + + K + + +T +LVT K+++L AD I+ +
Sbjct: 791 YQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMK 850
Query: 621 EGSSYFYGTFSELQ 634
+GS GT ++Q
Sbjct: 851 DGSVLREGTLKDIQ 864
Score = 79.7 bits (195), Expect = 2e-14
Identities = 83/377 (22%), Positives = 152/377 (40%), Gaps = 47/377 (12%)
Query: 263 SEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSV 322
SE E + +++A+ E ++ R EL T AY+ ++ + + +
Sbjct: 1140 SETAEGLTTIRAFRHETRFKQ-----RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1194
Query: 323 LPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQE 379
+ A I I + ++ + +T W V+ D +GA+ K+ FL
Sbjct: 1195 VLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL---- 1250
Query: 380 YKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGT 438
T+E + V W +EG ++ + + NN K
Sbjct: 1251 --TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK------------------ 1290
Query: 439 PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------ 486
PVLK + I+ GQ + + G TG+GK+SL + ++ +GKI G
Sbjct: 1291 PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLR 1350
Query: 487 -RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
R+S Q + G+I+ N+ + R ++ QL+ + + V+ EGG
Sbjct: 1351 SRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1410
Query: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
S GQR LARA + + + ++D +D+ TE I + V A++T + +
Sbjct: 1411 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE-NILQKVVMTAFADRTVVTIAH 1469
Query: 606 KMEHLKKADKILILHEG 622
++ + A +L+ EG
Sbjct: 1470 RVSSIMDAGLVLVFSEG 1486
Score = 70.9 bits (172), Expect = 9e-12
Identities = 70/309 (22%), Positives = 133/309 (43%), Gaps = 32/309 (10%)
Query: 1201 DDIWPSGGQM----TVKDLTAKYTEG------GNAILENISFSISPGQRVGLLGRTGSGK 1250
DD W +G + K T T G G A L NI I GQ ++G+ G GK
Sbjct: 616 DDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGK 675
Query: 1251 STLLSAFLRLLNT-EGEIQIDGVSWDSITLQQWRK----AFGVIPQKVFIFSGTFRKNLD 1305
S+LL A L + T EG++ V+ + + R + QK ++ + T +N+
Sbjct: 676 SSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENIT 735
Query: 1306 PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAK 1365
++ Q V D L+ I+ P + + G LS G +Q +C+AR++
Sbjct: 736 FGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTN 795
Query: 1366 ILLLDEPSAHLD-PVTYQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVR 1422
I+ LD+P + LD ++ +++ + + D T++L H+++ + + +++ V
Sbjct: 796 IVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVL 855
Query: 1423 Q--------------YDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALK 1468
+ Y+ + L+N + + +D+ L S+ A ++
Sbjct: 856 REGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQME 915
Query: 1469 EETEEEVQD 1477
+E EEE ++
Sbjct: 916 DEDEEEEEE 924
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 285 bits (728), Expect = 3e-76
Identities = 190/648 (29%), Positives = 327/648 (50%), Gaps = 45/648 (6%)
Query: 797 APQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDDMESIPAVTT---WNTYLRYI 853
A Q L + S+E ++ +E EE+ +E D+M ++ + T W T RY+
Sbjct: 927 ADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYL 986
Query: 854 TVHKSLIFVLIWCLVIFLAEVAASLVVL---WLLGNTPLQDKGNSTHSRNNSYAVIITST 910
T F+LI L+IF + S++V WL T S +S NN+ +
Sbjct: 987 T--SGGFFLLI--LMIFSKLLKHSVIVAIDYWLATWT-------SEYSINNTGK----AD 1031
Query: 911 SSYYV--FYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
+YYV F I G L + L + +T +K LHH +L+ ++ P+ +T
Sbjct: 1032 QTYYVAGFSILCGAGIFLCLV---TSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTP 1088
Query: 969 AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
G ILNRFS D I+D +P T+ + L+ + AI +++ P VA +P+ VAF
Sbjct: 1089 LGLILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGMISYATPVFLVALLPLGVAFYF 1148
Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
++ YF S+ L++L+ + P+ H + +GL T+RAF + F+ + + +
Sbjct: 1149 IQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQRMLELTDTNNIA 1208
Query: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVN 1148
+ + RW ++R + + + + SI + G VG+ L A+ I + L W V
Sbjct: 1209 YLFLSAANRWLEVRTDYLGACIVLTASIASI-SGSSNSGLVGLGLLYALTITNYLNWVVR 1267
Query: 1149 SSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGG 1208
+ D++ M +V +V F+ M +E G + + E+ WP G
Sbjct: 1268 NLADLEVQMGAVKKVNSFLTMESENY---------EGTMDPSQVPEH--------WPQEG 1310
Query: 1209 QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEI 1267
++ + DL +Y +L+++ I PGQ+VG+ GRTGSGKS+L AF R+++ +G+I
Sbjct: 1311 EIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKI 1370
Query: 1268 QIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSV 1327
IDG+ + L R +I Q +FSG+ R NLDP + +D +W+ + L+++
Sbjct: 1371 VIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNM 1430
Query: 1328 IEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRT 1387
++ PG LD V+ +GG S G +QL CLAR+ + K+ IL++DE +A +D T I+++
Sbjct: 1431 VKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKV 1490
Query: 1388 LKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
+ AFAD TV+ HR+ ++++ LV E + + D++ LL ++
Sbjct: 1491 VMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKN 1538
Score = 213 bits (541), Expect = 1e-54
Identities = 177/686 (25%), Positives = 324/686 (47%), Gaps = 67/686 (9%)
Query: 10 SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
+++SK + W ++ +++ ++L I ++P +V + L + E E +++A
Sbjct: 221 NLLSKATYWWMNTLIISAHKKPIDLKAIGKLPIAMRAVTNYVCLKDAYE-EQKKKVADHP 279
Query: 66 N--PKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDP------------ 111
N P + A+ R F + F YL ++ PL + I+ +
Sbjct: 280 NRTPSIWLAMYRAFGRPILLSSTFRYLADLLGFAGPLCISGIVQRVNETQNGTNNTTGIS 339
Query: 112 ---DNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLS 168
+KE A L + L L I++ L + + G+ +R A+ ++IY K L+LS
Sbjct: 340 ETLSSKEFLENAYVLAVLLFLALILQRTFLQASYYVTIETGINLRGALLAMIYNKILRLS 399
Query: 169 SRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCG 226
+ L ++++GQ+ +L++ N+ L L +W P+Q+ + + L++ LL +SA G
Sbjct: 400 TSNLSMGEMTLGQINNLVAIETNQLMWFLFLCPNLWAMPVQIIMGVILLYNLLGSSALVG 459
Query: 227 LGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIE 286
+++LA Q + + + + +ERL T+E+++ I+ +K Y WE K +E
Sbjct: 460 AAVIVLLAPIQYFIATKLAEAQKSTLDYSTERLKKTNEILKGIKLLKLYAWEHIFCKSVE 519
Query: 287 NLRQTELKLTRKAAYVRYFNSSAFFFSGFFV--VFLSVLPYALIKGIILR--KIFTTISF 342
R EL + + Y + S F + + V + + +A G L+ + F ++S
Sbjct: 520 ETRMKELSSLK--TFALYTSLSIFMNAAIPIAAVLATFVTHAYASGNNLKPAEAFASLSL 577
Query: 343 CIVLRMAVTRQF--PWAVQTWYDSLGAINKIQDFLQKQE-----YKTLEYNLTTTEV--- 392
+L VT F V+ ++ ++ K+ +FL E ++T E +L
Sbjct: 578 FHIL---VTPLFLLSTVVRFAVKAIISVQKLNEFLLSDEIGDDSWRTGESSLPFESCKKH 634
Query: 393 --VMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN--FSL-LGTPVLKDINFK 447
V + G L + R D ++ +N FS G L +I+ +
Sbjct: 635 TGVQPKTINRKQPGRYHLDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSGLATLSNIDIR 694
Query: 448 IERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-----------------RISF 490
I GQL + G G GK+SLL+ I+GE++ EGK+ S +++
Sbjct: 695 IPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAY 754
Query: 491 CSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSG 550
+Q W++ T++ENI FG +++ RY++V AC L+ DI D +GE GI LSG
Sbjct: 755 AAQKPWLLNATVEENITFGSPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSG 814
Query: 551 GQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMAN--KTRILVTSKME 608
GQR RI +ARA+Y++ ++ LD PF LD+ + + + K + + +T +LVT K++
Sbjct: 815 GQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQ 874
Query: 609 HLKKADKILILHEGSSYFYGTFSELQ 634
+L AD I+ + +GS GT ++Q
Sbjct: 875 YLTHADWIIAMKDGSVLREGTLKDIQ 900
Score = 79.7 bits (195), Expect = 2e-14
Identities = 83/377 (22%), Positives = 152/377 (40%), Gaps = 47/377 (12%)
Query: 263 SEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSV 322
SE E + +++A+ E ++ R EL T AY+ ++ + + +
Sbjct: 1176 SETAEGLTTIRAFRHETRFKQ-----RMLELTDTNNIAYLFLSAANRWLEVRTDYLGACI 1230
Query: 323 LPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQE 379
+ A I I + ++ + +T W V+ D +GA+ K+ FL
Sbjct: 1231 VLTASIASISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFL---- 1286
Query: 380 YKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGT 438
T+E + V W +EG ++ + + NN K
Sbjct: 1287 --TMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK------------------ 1326
Query: 439 PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------ 486
PVLK + I+ GQ + + G TG+GK+SL + ++ +GKI G
Sbjct: 1327 PVLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLR 1386
Query: 487 -RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
R+S Q + G+I+ N+ + R ++ QL+ + + V+ EGG
Sbjct: 1387 SRLSIILQDPILFSGSIRFNLDPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1446
Query: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
S GQR LARA + + + ++D +D+ TE I + V A++T + +
Sbjct: 1447 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATE-NILQKVVMTAFADRTVVTIAH 1505
Query: 606 KMEHLKKADKILILHEG 622
++ + A +L+ EG
Sbjct: 1506 RVSSIMDAGLVLVFSEG 1522
Score = 71.2 bits (173), Expect = 7e-12
Identities = 66/293 (22%), Positives = 129/293 (44%), Gaps = 28/293 (9%)
Query: 1213 KDLTAKYTEG------GNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
+D+ K T G G A L NI I GQ ++G+ G GKS+LL A L + T EG
Sbjct: 668 EDIAIKVTNGYFSWGSGLATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEG 727
Query: 1266 EIQIDGVSWDSITLQQWRK----AFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADE 1321
++ V+ + + R + QK ++ + T +N+ ++ Q V D
Sbjct: 728 KVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDA 787
Query: 1322 VGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD-PVT 1380
L+ I+ P + + G LS G +Q +C+AR++ I+ LD+P + LD ++
Sbjct: 788 CSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLS 847
Query: 1381 YQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVRQ--------------Y 1424
+++ + + D T++L H+++ + + +++ V + Y
Sbjct: 848 DHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELY 907
Query: 1425 DSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEEVQD 1477
+ + L+N + + +D+ L S+ A +++E EEE ++
Sbjct: 908 EHWKTLMNRQDQELEKDMEADQTTLERKTLRRAMYSREAKAQMEDEDEEEEEE 960
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 285 bits (728), Expect = 3e-76
Identities = 191/660 (28%), Positives = 326/660 (49%), Gaps = 41/660 (6%)
Query: 786 KTTASTRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD----MESIP 841
K T + RK + PQ SR +S GL EE EE+ E DD M
Sbjct: 940 KETVTERKATEPPQG-------LSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQR 992
Query: 842 AVTTWNTYLRYITVHKSLIFVLIWCLVIF---LAEVAASLVVLWLLGNTPLQDKGNSTHS 898
A W +Y+ S +L+ L++F L + + WL T + +
Sbjct: 993 AEIPWRACAKYL----SSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTD-SALTLTPAA 1047
Query: 899 RNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQ 958
RN S + T + Y ++ + + + + + T + V+K LH +L+ ++
Sbjct: 1048 RNCSLSQECTLDQTVYAM-VFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLLNRIIL 1106
Query: 959 APMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVA 1018
APM T G ILNRFS D +D +P T+ + L+ + A+AV++ + P VA
Sbjct: 1107 APMRFFETTPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYVTPVFLVA 1166
Query: 1019 TVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLF 1078
+P+ + ++ YF S+ L+QL+ + P+ +H +++GL T+RAF + F+
Sbjct: 1167 LLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKL 1226
Query: 1079 HKALNLHTANWFLYLSTLRWFQMRIEMI--FVIFFIAVTFISILTTGE-GEGRVGIILTL 1135
+ + + + RW ++R+E I V+ AVT IS E G VG+ LT
Sbjct: 1227 LEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTY 1286
Query: 1136 AMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIEN 1195
A+ + + L W V + D++ + +V R+ + E G L+ +I +N
Sbjct: 1287 ALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESY---------EGLLAPSLIPKN 1337
Query: 1196 SHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLS 1255
WP G++ +++L+ +Y +L++++ I+PGQ++G+ GRTGSGKS+
Sbjct: 1338 --------WPDQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSL 1389
Query: 1256 AFLRLLNT-EGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQE 1314
AF R+++T EG I IDG+ + L R +I Q +FSGT R NLDP + SD
Sbjct: 1390 AFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDST 1449
Query: 1315 IWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSA 1374
+W+ + L+ V++ PG LD ++ +GG S G +QL CLAR+ + K I ++DE +A
Sbjct: 1450 LWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATA 1509
Query: 1375 HLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNER 1434
+D T I+++ + AFAD TV+ HR+ +L +V++ + ++D +KLL+ +
Sbjct: 1510 SIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK 1569
Score = 197 bits (500), Expect = 8e-50
Identities = 165/700 (23%), Positives = 317/700 (45%), Gaps = 80/700 (11%)
Query: 10 SVVSKLFFSWTRPILRKGYRQRLELSDIYQIP----SVDSADNLSEKLEREWDRELASKK 65
+++SK + W ++ +++ ++L I ++P ++ + L E + + +++ +
Sbjct: 223 NLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQ 282
Query: 66 NPKLI-NALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDN----------- 113
+ I AL F R + F L ++ PL + I+ +N
Sbjct: 283 GARAIWQALSHAFGRRLVLSSTFRILADLLGFAGPLCIFGIVDHLGKENDVFQPKTQFLG 342
Query: 114 ------KEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKL 167
+E + A L + L L +++ L + + G+ +R A+ + IY K + L
Sbjct: 343 VYFVSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHL 402
Query: 168 SSRVLD--KISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFC 225
S+ L +++ GQ+ +L++ + N+ L +W P+Q+ + + L++ +L SA
Sbjct: 403 STSNLSMGEMTAGQICNLVAIDTNQLMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALI 462
Query: 226 GLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMI 285
G +I+LA Q + + + + +ERL T+EM+ I+ +K Y WE +
Sbjct: 463 GAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRV 522
Query: 286 ENLRQTELKLTRKAAY---VRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISF 342
E R+ E+ R A + F ++A + + F+ + + F ++S
Sbjct: 523 ETTRRKEMTSLRAFAIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSL 582
Query: 343 CIVLRMAVTRQFPWA--VQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAF 400
+L VT F + V++ +L ++ K+ +FL E + E E + +
Sbjct: 583 FHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIR--EEQCAPHEPTPQGPASK 637
Query: 401 WEEGFGELFEKAKQNNNNRKTSNGD-DSLF-----------------FSNFSLLGTPVLK 442
++ + + + + + G SL + ++ G P L
Sbjct: 638 YQAVPLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGIPTLS 697
Query: 443 DINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGK--------------------- 481
+I +I RGQL + G G GK+SLL+ +GE++ G
Sbjct: 698 NITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERET 757
Query: 482 -----IKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEK 536
I+ G +++ SQ W++ T++ENIIF +++ RY+ VI+AC L+ DI
Sbjct: 758 ATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHG 817
Query: 537 DNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMA 596
D +GE GI LSGGQR RIS+ARA+Y+ A++ LD PF LD+ + ++ + +L+
Sbjct: 818 DQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLR 877
Query: 597 N--KTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQ 634
+ +T +LVT K+++L AD I+ + +G+ GT + Q
Sbjct: 878 DDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQ 917
Score = 72.8 bits (177), Expect = 2e-12
Identities = 84/380 (22%), Positives = 159/380 (41%), Gaps = 47/380 (12%)
Query: 263 SEMIENIQSVKAYCWEEAME-KMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLS 321
+E +E + +++A+ +E + K++E + A R+ + V+ +
Sbjct: 1204 AETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAA 1263
Query: 322 VLPYALIKGIILRKIFT-TISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQK 377
V I + R++ + + + V+ W V+ D LGA+ +I L K
Sbjct: 1264 VTS---ISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLL-K 1319
Query: 378 QEYKTLEYNLTTTEVVMENVTAFW-EEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLL 436
E ++ E L ++ +N W ++G ++ QN + R D SL
Sbjct: 1320 TEAESYE-GLLAPSLIPKN----WPDQGKIQI-----QNLSVRY----DSSL-------- 1357
Query: 437 GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG---------- 486
PVLK +N I GQ + + G TG+GK+S + ++ EG I G
Sbjct: 1358 -KPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHT 1416
Query: 487 ---RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGE 543
R+S Q + GTI+ N+ + ++ QL+ + + ++ E
Sbjct: 1417 LRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVKALPGGLDAIITE 1476
Query: 544 GGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILV 603
GG S GQR LARA + ++++D +D+ TE I + V A++T + +
Sbjct: 1477 GGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATE-NILQKVVMTAFADRTVVTI 1535
Query: 604 TSKMEHLKKADKILILHEGS 623
++ + AD +++L G+
Sbjct: 1536 AHRVHTILSADLVIVLKRGA 1555
Score = 55.5 bits (132), Expect = 4e-07
Identities = 63/293 (21%), Positives = 124/293 (42%), Gaps = 43/293 (14%)
Query: 1219 YTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQ-IDG-VSWDS 1276
+T G L NI+ I GQ ++G+ G GKS+LL A L GE+Q + G V W S
Sbjct: 688 WTPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAAL------GEMQKVSGAVFWSS 741
Query: 1277 ITLQQ------------------WRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKV 1318
+ + R QK ++ + T +N+ ++ Q V
Sbjct: 742 LPDSEIGEDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMV 801
Query: 1319 ADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD- 1377
+ L+ I+ P + + G LS G +Q + +AR++ A ++ LD+P + LD
Sbjct: 802 IEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDI 861
Query: 1378 PVTYQIIRRTLKQAFAD--CTVILCEHRIEAMLECQQFLVIEENKVRQ------------ 1423
++ +++ + + D TV+L H+++ + + +++ +++
Sbjct: 862 HLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSEC 921
Query: 1424 --YDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQIAALKEETEEE 1474
++ + L+N + + + ++R P + S+ S EE EEE
Sbjct: 922 QLFEHWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEE 974
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 280 bits (716), Expect = 7e-75
Identities = 181/600 (30%), Positives = 302/600 (50%), Gaps = 50/600 (8%)
Query: 845 TWNTYLRYITVHK----SLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQ--DKGNSTHS 898
TW TY YI SL V ++ L+I A + + LWL + + +GN T
Sbjct: 778 TWKTYHTYIKASGGYLLSLFTVFLFLLMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMC 837
Query: 899 RNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQ 958
++ + ++Y +L G +G T + S LH + +L+
Sbjct: 838 E---VGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILK 894
Query: 959 APMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVA 1018
+PMS +T G ++NRFSKD+ LD LP +F+Q +V+ + ++A + P + +
Sbjct: 895 SPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILVILAAVFPAVLLV 954
Query: 1019 TVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLF 1078
+ V F +L F + Q+LK++E+ RSP FTH+ +S++GL + A+G++
Sbjct: 955 VASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTHITSSMQGLGIIHAYGKK------- 1007
Query: 1079 HKALNLHTANWFLYLS-TLRWFQMRIEMIF------VIFFIAVTFISILTTGEGEGRVGI 1131
+ H LY + LRWF +R++++ V + ++F SI T+ +G +
Sbjct: 1008 ESCITYH----LLYFNCALRWFALRMDVLMNILTFTVALLVTLSFSSISTSSKG-----L 1058
Query: 1132 ILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVM 1191
L+ + + LQ V + + + SV + ++I + T P K G K
Sbjct: 1059 SLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVP----ECTHPLKVGTCPKD- 1113
Query: 1192 IIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKS 1251
WPS G++T +D +Y + +L++++ +I GQ VG++GRTGSGKS
Sbjct: 1114 ------------WPSRGEITFRDYQMRYRDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKS 1161
Query: 1252 TLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQW 1310
+L A RL+ G I ID V ++L+ R VIPQ +F GT R NLDP+E
Sbjct: 1162 SLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNLDPFESH 1221
Query: 1311 SDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLD 1370
+D+ +W+V + +R I + P KL + + G S G +QL+C+AR++L +KI+LLD
Sbjct: 1222 TDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLD 1281
Query: 1371 EPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKL 1430
E +A +D T +++ T+K AF CTV+ HR+ +L C LV+E KV ++D + L
Sbjct: 1282 EATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVL 1341
Score = 263 bits (672), Expect = 9e-70
Identities = 169/655 (25%), Positives = 323/655 (49%), Gaps = 35/655 (5%)
Query: 4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELAS 63
+P++ A ++S FSW P++ KGYRQRL + + + + DS+D +++ WD E+A
Sbjct: 44 NPVDDAGLLSFATFSWLTPVMVKGYRQRLTVDTLPPLSTYDSSDTNAKRFRVLWDEEVAR 103
Query: 64 KKNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIA-IY 122
K A W+F + + + + +G +I + + ER+ ++
Sbjct: 104 VGPEK---ASLSHVVWKFQRTRVLMDIVANILCIIMAAIGPVILIHQILQQTERTSGKVW 160
Query: 123 LGIGLCLLFIVR--TLLLHPAIFGL--HHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
+GIGLC+ T + A+ + +++++A+ +L+++ + S + L IS+G
Sbjct: 161 VGIGLCIALFATEFTKVFFWALAWAINYRTAIRLKVALSTLVFENLV--SFKTLTHISVG 218
Query: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
+++++LS++ E P+ + + +L +A G+ ++ Q
Sbjct: 219 EVLNILSSDSYSLFEAALFCPLPATIPILMVFCAAYAFFILGPTALIGISVYVIFIPVQM 278
Query: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
+ ++ +R +R+ +E + I+ +K Y WE++ I+++R+ E KL K
Sbjct: 279 FMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAWEKSFTNTIQDIRRRERKLLEK 338
Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLRMAVTRQ----F 354
A +V+ NS+ + L++ + L++ RK+ ++F ++ V +
Sbjct: 339 AGFVQSGNSALAPIVSTIAIVLTLSCHILLR----RKLTAPVAFSVIAMFNVMKFSIAIL 394
Query: 355 PWAVQTWYDSLGAINKIQDFL---QKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEK 411
P++++ ++ ++ +++ L Y T + T +++ N T WE
Sbjct: 395 PFSIKAMAEANVSLRRMKKILIDKSPPSYITQPEDPDTV-LLLANATLTWEHEASRKSTP 453
Query: 412 AKQNNNNRKTSNGDDSLFFSNFSLLGT-------------PVLKDINFKIERGQLLAVAG 458
K N R S +S S VL I+F + +G++L + G
Sbjct: 454 KKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSLKSVLHSISFVVRKGKILGICG 513
Query: 459 STGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYR 518
+ G+GK+SLL ++G+++ +G + +G +++ SQ +WI G ++ENI+FG YD RY+
Sbjct: 514 NVGSGKSSLLAALLGQMQLQKGVVAVNGTLAYVSQQAWIFHGNVRENILFGEKYDHQRYQ 573
Query: 519 SVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYL 578
++ C L++D+S D +GE G+ LSGGQR RISLARAVY D LYLLD P +
Sbjct: 574 HTVRVCGLQKDLSNLPYGDLTEIGERGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAV 633
Query: 579 DVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
D K +FE C+ K + KT +LVT +++ L+ D++++L +G GT EL
Sbjct: 634 DAHVGKHVFEECIKKTLRGKTVVLVTHQLQFLESCDEVILLEDGEICEKGTHKEL 688
Score = 88.6 bits (218), Expect = 4e-17
Identities = 61/255 (23%), Positives = 123/255 (48%), Gaps = 18/255 (7%)
Query: 1225 AILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDSITLQQWR 1283
++L +ISF + G+ +G+ G GSGKS+LL+A L + + G + ++G
Sbjct: 494 SVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNG------------ 541
Query: 1284 KAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
+ Q+ +IF G R+N+ E++ Q GL+ + P + + G
Sbjct: 542 -TLAYVSQQAWIFHGNVRENILFGEKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGERG 600
Query: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADCTVILCEH 1402
LS G +Q + LAR+V S ++ LLD+P + +D V + +K+ TV+L H
Sbjct: 601 LNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLVTH 660
Query: 1403 RIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKP 1462
+++ + C + +++E+ ++ + + ++L+ ER + + I ++ ++ +
Sbjct: 661 QLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLI---HNLRGLQFKDPEHLYNAA 717
Query: 1463 QIAALKEETEEEVQD 1477
+ A KE E +D
Sbjct: 718 MVEAFKESPAEREED 732
Score = 67.4 bits (163), Expect = 1e-10
Identities = 97/498 (19%), Positives = 200/498 (40%), Gaps = 80/498 (16%)
Query: 155 AMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLA------LAHFVWIAPLQV 208
++ ++ K LK D G+L++ S ++++ D L L F + + V
Sbjct: 883 SLHDTVFDKILKSPMSFFDTTPTGRLMNRFSKDMDELDVRLPFHAENFLQQFFMVVFILV 942
Query: 209 ALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIEN 268
+L + +L A +GF I+L +F G+ + R+ + ITS M +
Sbjct: 943 -ILAAVFPAVLLVVASLAVGFFILLRIFHRGVQELKKVENVSRSPWFTH---ITSSM-QG 997
Query: 269 IQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALI 328
+ + AY +E+ ++ YFN + +F+ V +++L + +
Sbjct: 998 LGIIHAYGKKESCITY----------------HLLYFNCALRWFALRMDVLMNILTFTVA 1041
Query: 329 KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLT 388
+ T+SF + + + +Q ++ + + +T + T
Sbjct: 1042 -------LLVTLSFSSISTSSKGLSLSYIIQ--------LSGLLQVCVRTGTET-QAKFT 1085
Query: 389 TTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLL---GTP-VLKDI 444
+ E++ E ++ E L + K + F ++ + TP VL +
Sbjct: 1086 SVELLREYISTCVPECTHPL-----KVGTCPKDWPSRGEITFRDYQMRYRDNTPLVLDSL 1140
Query: 445 NFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKI-------------KHSGRISFC 491
N I+ GQ + + G TG+GK+SL M + +EP+ G I +++
Sbjct: 1141 NLNIQSGQTVGIVGRTGSGKSSLGMALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVI 1200
Query: 492 SQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGG 551
Q + GT++ N+ S+ + V++ + + I K EK + E G S G
Sbjct: 1201 PQDPVLFVGTVRYNLDPFESHTDEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVG 1260
Query: 552 QRARISLARAVYKDADLYLLDSPFGYLDVLTE-------KEIFESCVCKLMANKTRILVT 604
+R + +ARA+ +++ + LLD +D T+ K+ F+ C T + +
Sbjct: 1261 ERQLLCVARALLRNSKIILLDEATASMDSKTDTLVQNTIKDAFKGC--------TVLTIA 1312
Query: 605 SKMEHLKKADKILILHEG 622
++ + D +L++ G
Sbjct: 1313 HRLNTVLNCDHVLVMENG 1330
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 280 bits (715), Expect = 1e-74
Identities = 161/519 (31%), Positives = 286/519 (55%), Gaps = 37/519 (7%)
Query: 918 IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFS 977
I+V +A A GF + S ILH ++L+++L+APM +T G I+NRF+
Sbjct: 1036 IFVFIAHFWSAFGF----------VHASNILHKQLLNNILRAPMRFFDTTPTGRIVNRFA 1085
Query: 978 KDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTS 1037
DI+ +DD LP ++ +I L +I + ++ + P + +P+ + ++ ++ +++ TS
Sbjct: 1086 GDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFYVSTS 1145
Query: 1038 QQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANW--FLYLST 1095
+QL++L+S RSPI++H ++ GL +RAF Q F L H + + T F ++++
Sbjct: 1146 RQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRF--LKHNEVRIDTNQKCVFSWITS 1203
Query: 1096 LRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDV 1153
RW +R+E++ +FF A+ + T G+ VG +L+ A+NI TL W V + ++
Sbjct: 1204 NRWLAIRLELVGNLTVFFSALMMVIYRDTLSGD-TVGFVLSNALNITQTLNWLVRMTSEI 1262
Query: 1154 DSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVK 1213
++ + +V R+ ++ + E +P + WPS G++
Sbjct: 1263 ETNIVAVERITEYTKVENEAPWVTDKRPPPD-------------------WPSKGKIQFN 1303
Query: 1214 DLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEG-EIQIDGV 1272
+ +Y + +L I+ I +++G++GRTG+GKS+L + R+L G +I IDGV
Sbjct: 1304 NYQVRYRPELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGV 1363
Query: 1273 SWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFP 1332
SI L R+ +IPQ +FSG+ R NLDP+ +SD+EIWK + L+S +
Sbjct: 1364 DIASIGLHDLREKLTIIPQDPILFSGSLRMNLDPFNNYSDEEIWKALELAHLKSFVASLQ 1423
Query: 1333 GKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAF 1392
L + + G LS G +QL+CL R++L K+KIL+LDE +A +D T +I+ T++ F
Sbjct: 1424 LGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEF 1483
Query: 1393 ADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLL 1431
A CTVI HR+ +++ + +V++ K+ + S ++LL
Sbjct: 1484 AHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522
Score = 243 bits (619), Expect = 1e-63
Identities = 181/698 (25%), Positives = 311/698 (44%), Gaps = 88/698 (12%)
Query: 4 SPLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL-- 61
+P AS +S + +SW I+ KGY++ L L D++++ L K E REL
Sbjct: 193 NPSSIASFLSSITYSWYDSIILKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQK 252
Query: 62 ---------------------------------------ASKKNPK-----------LIN 71
KK K L+
Sbjct: 253 ARRALQRRQEKSSQQNSGARLPGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMK 312
Query: 72 ALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLF 131
AL + F+ + + + ++ V P LL +++ S+ D I I L
Sbjct: 313 ALFKTFYMVLLKSFLLKLVNDIFTFVSPQLL-KLLISFASDRDTYLWIGYLCAILLFTAA 371
Query: 132 IVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKF 191
++++ L +G+++R A+ + +YKK L LS+ + ++G+ V+L+S + K
Sbjct: 372 LIQSFCLQCYFQLCFKLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKL 431
Query: 192 DEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQR 251
+ H +W + LQ+ L + +W L S G+G ++++ A L + +
Sbjct: 432 MDVTNFMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKN 491
Query: 252 AGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFF 311
+RL I +E++ I+ +K + WE + ++NLR+ ELK + ++ F
Sbjct: 492 MKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKNLLAFSQLQCVVIFVFQ 551
Query: 312 FSGFFVVFLSVLPYALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAI 368
+ V ++ Y L+ + +K FT+I+ +LR ++ P + + + +
Sbjct: 552 LTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS-MLPMMISSMLQASVST 610
Query: 369 NKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSL 428
+++ +L + T F+KA Q + T D
Sbjct: 611 ERLEKYLGGDDLDTSAIRHDCN------------------FDKAMQFSEASFTWEHDSEA 652
Query: 429 FFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRI 488
++D+N I GQL+AV G G+GK+SL+ ++GE+E G I G
Sbjct: 653 -----------TVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTT 701
Query: 489 SFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITL 548
++ Q SWI GTIK+NI+FG ++E RY+ V++AC L D+ D +GE GI L
Sbjct: 702 AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLPDLEMLPGGDLAEIGEKGINL 761
Query: 549 SGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSK 606
SGGQ+ RISLARA Y++ D+YLLD P +D K IF + L+ KTR+LVT
Sbjct: 762 SGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHS 821
Query: 607 MEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKL 644
M L + D+I++L G+ G++S L + +F+ L
Sbjct: 822 MHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFAKNL 859
Score = 76.6 bits (187), Expect = 2e-13
Identities = 104/474 (21%), Positives = 194/474 (40%), Gaps = 42/474 (8%)
Query: 970 GGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIML 1029
G +N S D L D+ + +L IV+ + L P + +A V V+V I +
Sbjct: 418 GETVNLMSVDAQKLMDVTNFMHMLWSSVLQIVLSIFFLWRELGPSV-LAGVGVMVLVIPI 476
Query: 1030 RAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANW 1089
A S+ ++ + + + L G+ L+ F +P F N
Sbjct: 477 NAILSTKSKTIQVKNMKNKDKRLKIMNEILSGIKILKYFAWEPSFRDQVQNLRKKELKN- 535
Query: 1090 FLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNS 1149
L + Q++ +IFV F + +S++T +L + NI+ + +
Sbjct: 536 -----LLAFSQLQCVVIFV-FQLTPVLVSVVTFSV------YVLVDSNNILDAQK--AFT 581
Query: 1150 SIDVDSLMRSVSRVFKFI--DMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSG 1207
SI + +++R + + M T+ + Y G ++ S ++ D +
Sbjct: 582 SITLFNILRFPLSMLPMMISSMLQASVSTERLEKYLGGD-----DLDTSAIRHDCNFDKA 636
Query: 1208 GQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGE 1266
Q + T + A + +++ I GQ V ++G GSGKS+L+SA L + N G
Sbjct: 637 MQFSEASFT--WEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGH 694
Query: 1267 IQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRS 1326
I I G + +PQ+ +I +GT + N+ +++++ +V + L
Sbjct: 695 ITIKGTT-------------AYVPQQSWIQNGTIKDNILFGTEFNEKRYQQVLEACALLP 741
Query: 1327 VIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIR 1385
+E PG + + G LS G KQ + LAR+ I LLD+P + +D V I
Sbjct: 742 DLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFN 801
Query: 1386 RTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
+ L T +L H + + + + +V+ + + S LL ++ F
Sbjct: 802 KVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEF 855
Score = 60.1 bits (144), Expect = 2e-08
Identities = 101/554 (18%), Positives = 210/554 (37%), Gaps = 65/554 (11%)
Query: 111 PDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSR 170
P ++ + + +Y +GL V A FG H + + + I L+ R
Sbjct: 1016 PASQRDMRVGVYGALGLAQGIFVFIAHFWSA-FGFVHASNILHKQLLNNI----LRAPMR 1070
Query: 171 VLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFC----G 226
D G++V+ + +++ D+ L + WI + ++ L+ + F
Sbjct: 1071 FFDTTPTGRIVNRFAGDISTVDDTLPQSLRSWITCF-LGIISTLVMICMATPVFTIIVIP 1129
Query: 227 LGFLIV-LALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMI 285
LG + V + +F R + + I SE + + ++A+ ++ K
Sbjct: 1130 LGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHF---SETVSGLPVIRAFEHQQRFLKHN 1186
Query: 286 ENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIV 345
E T K + + G VF S L + + + T+ F +
Sbjct: 1187 EVRIDTNQKCVFSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGD---TVGFVLS 1243
Query: 346 LRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGF 405
+ +T+ W V+ + +E N+ E + E +
Sbjct: 1244 NALNITQTLNWLVRMTSE-------------------IETNIVAVERITE---------Y 1275
Query: 406 GELFEKAKQNNNNRKTSN--GDDSLFFSNFSLLGTP----VLKDINFKIERGQLLAVAGS 459
++ +A + R + + F+N+ + P VL+ I I + + V G
Sbjct: 1276 TKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDLVLRGITCDIGSMEKIGVVGR 1335
Query: 460 TGAGKTSLLMVIMGELEPSEGKIKHSG-------------RISFCSQFSWIMPGTIKENI 506
TGAGK+SL + LE + G+I G +++ Q + G+++ N+
Sbjct: 1336 TGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNL 1395
Query: 507 IFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDA 566
+Y + ++ L+ ++ + + E G LS GQR + L RA+ + +
Sbjct: 1396 DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKS 1455
Query: 567 DLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYF 626
+ +LD +D+ T+ + ++ + A+ T I + ++ + +DK+++L G
Sbjct: 1456 KILVLDEATAAVDLETD-NLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIE 1514
Query: 627 YGTFSELQNLQPDF 640
G+ EL + F
Sbjct: 1515 CGSPEELLQIPGPF 1528
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 279 bits (714), Expect = 1e-74
Identities = 187/658 (28%), Positives = 322/658 (48%), Gaps = 44/658 (6%)
Query: 781 QNIHRKTTAS----TRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836
Q +H++ T+ T K++ P+ SQ + E +N + E
Sbjct: 731 QKMHKEATSDMLQDTAKIAEKPKVE-----------SQALATSLEESLNGNAVPEHQLTQ 779
Query: 837 MESIPAVT-TWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVL--WLLGNTPLQDKG 893
E + + +W Y YI ++ C++ F + L + W L Q G
Sbjct: 780 EEEMEEGSLSWRVYHHYIQAAGGY---MVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSG 836
Query: 894 -NSTHSRNNSYAVI--ITSTSSYYVFYIYVGV-ADTLLAMGFFRGLPLVHTLITVSKILH 949
NS+ N + A + I + + G+ A L+ +G S LH
Sbjct: 837 TNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALH 896
Query: 950 HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
+K+ + V + PMS +T+ G +LN F+ D+ LD LLP+ F+ L L+VI + +V+
Sbjct: 897 NKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVS 956
Query: 1010 VLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFG 1069
VL PYI + ++V + F + K+LE+ RSP+F+H++ SL+GL ++ +G
Sbjct: 957 VLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYG 1016
Query: 1070 RQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT-FISILTTGEGEGR 1128
+ F + F + + L+LS+ RW +R+E++ + +AV F++ +
Sbjct: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076
Query: 1129 VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLS 1188
+ + + + + S+ Q ++ ++ +V R+ +++ M P
Sbjct: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP------------- 1123
Query: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGS 1248
+ +E + + WP G++ +D KY + +L I+ +I + VG++GRTGS
Sbjct: 1124 --LHMEGTSCPQG--WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
Query: 1249 GKSTLLSAFLRLLNT-EGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPY 1307
GKS+L A RL+ G I IDGV SI L+ R VIPQ + SGT R NLDP+
Sbjct: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
Query: 1308 EQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367
++ +DQ+IW + L I +FP KL +V+ G S G +QL+C+AR+VL +KI+
Sbjct: 1240 DRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKII 1299
Query: 1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYD 1425
L+DE +A +D T +I+RT+++AF CTV++ HR+ +L C LV+ KV ++D
Sbjct: 1300 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1357
Score = 250 bits (639), Expect = 6e-66
Identities = 180/642 (28%), Positives = 314/642 (48%), Gaps = 20/642 (3%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
PL+ A + S L SW P++ + R RL+ + I + D++D ++L R W+ E++ +
Sbjct: 85 PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRR 144
Query: 65 --KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIY 122
+ ++ + R R +F + + + P+L+ I Y EE+ +
Sbjct: 145 GIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS----EEQLGNVV 200
Query: 123 LGIGLCL-LFI---VRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
G+GLC LF+ V++L + ++ R A+ S ++K ++ S + I+ G
Sbjct: 201 HGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVI--HITSG 258
Query: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
+ +S + ++N EG+ V I + + + ++ +AF + +++
Sbjct: 259 EAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAV 318
Query: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
+ RM +K + + +R+ +TSE++ I+ +K Y WE+ K+IE+LR+ E KL K
Sbjct: 319 FMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEK 378
Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK-GIILRKIFTTISFCIVLRMAVTRQFPWA 357
V+ S F + VL + +K + F+ ++ +LR++V P A
Sbjct: 379 CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF-VPIA 437
Query: 358 VQTWYDSLGAINKIQDFLQKQEYKTLEYNLT--TTEVVMENVTAFWEEGFGELFEKAKQN 415
V+ +S A+ + + F ++ L + +V E T W++ + A +
Sbjct: 438 VKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALEL 497
Query: 416 NNNRKTSNG----DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471
N S G D+L P L IN + +G +L V G+TG+GK+SLL I
Sbjct: 498 ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557
Query: 472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDIS 531
+ E+ EG + G +++ Q +WI+ G I+ENI+ G +YD+ RY V+ C L D+
Sbjct: 558 LEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
Query: 532 KFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV 591
D +GE G+ LSGGQ+ RISLARAVY D +YLLD P +D K IFE C+
Sbjct: 618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI 677
Query: 592 CKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
K + KT +LVT ++++L+ +I++L G GT SEL
Sbjct: 678 KKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSEL 719
Score = 90.5 bits (223), Expect = 1e-17
Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 21/263 (7%)
Query: 1221 EGGNAI---LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDS 1276
E GN++ L I+ +S G +G+ G TGSGKS+LLSA L ++ EG + + G
Sbjct: 518 EEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG----- 572
Query: 1277 ITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLD 1336
+ +PQ+ +I SG R+N+ + +V L +E P
Sbjct: 573 --------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM 624
Query: 1337 FVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADC 1395
+ + G LS G KQ + LAR+V S +I LLD+P + +D V I +K+
Sbjct: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684
Query: 1396 TVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH-RN 1454
TV+L H+++ + C Q +++E K+ + + +L+ ++ + Q I + ++
Sbjct: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744
Query: 1455 SSKCKSKPQI--AALKEETEEEV 1475
++K KP++ AL EE +
Sbjct: 745 TAKIAEKPKVESQALATSLEESL 767
Score = 66.2 bits (160), Expect = 2e-10
Identities = 51/203 (25%), Positives = 96/203 (47%), Gaps = 28/203 (13%)
Query: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
VL IN I +++ + G TG+GK+SL M + +EP G+I G
Sbjct: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRS 1216
Query: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
++S Q ++ GTI+ N+ + + + ++ L + ISKF +K + + E G
Sbjct: 1217 KLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGG 1276
Query: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTE-------KEIFESCVCKLMANKT 599
S G+R + +ARAV +++ + L+D +D+ T+ +E F+ C T
Sbjct: 1277 NFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGC--------T 1328
Query: 600 RILVTSKMEHLKKADKILILHEG 622
+++ ++ + D IL++ G
Sbjct: 1329 VLVIAHRVTTVLNCDHILVMGNG 1351
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 279 bits (714), Expect = 1e-74
Identities = 187/658 (28%), Positives = 322/658 (48%), Gaps = 44/658 (6%)
Query: 781 QNIHRKTTAS----TRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836
Q +H++ T+ T K++ P+ SQ + E +N + E
Sbjct: 731 QKMHKEATSDMLQDTAKIAEKPKVE-----------SQALATSLEESLNGNAVPEHQLTQ 779
Query: 837 MESIPAVT-TWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVL--WLLGNTPLQDKG 893
E + + +W Y YI ++ C++ F + L + W L Q G
Sbjct: 780 EEEMEEGSLSWRVYHHYIQAAGGY---MVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSG 836
Query: 894 -NSTHSRNNSYAVI--ITSTSSYYVFYIYVGV-ADTLLAMGFFRGLPLVHTLITVSKILH 949
NS+ N + A + I + + G+ A L+ +G S LH
Sbjct: 837 TNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALH 896
Query: 950 HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
+K+ + V + PMS +T+ G +LN F+ D+ LD LLP+ F+ L L+VI + +V+
Sbjct: 897 NKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVS 956
Query: 1010 VLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFG 1069
VL PYI + ++V + F + K+LE+ RSP+F+H++ SL+GL ++ +G
Sbjct: 957 VLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYG 1016
Query: 1070 RQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT-FISILTTGEGEGR 1128
+ F + F + + L+LS+ RW +R+E++ + +AV F++ +
Sbjct: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076
Query: 1129 VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLS 1188
+ + + + + S+ Q ++ ++ +V R+ +++ M P
Sbjct: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP------------- 1123
Query: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGS 1248
+ +E + + WP G++ +D KY + +L I+ +I + VG++GRTGS
Sbjct: 1124 --LHMEGTSCPQG--WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
Query: 1249 GKSTLLSAFLRLLNT-EGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPY 1307
GKS+L A RL+ G I IDGV SI L+ R VIPQ + SGT R NLDP+
Sbjct: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
Query: 1308 EQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367
++ +DQ+IW + L I +FP KL +V+ G S G +QL+C+AR+VL +KI+
Sbjct: 1240 DRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKII 1299
Query: 1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYD 1425
L+DE +A +D T +I+RT+++AF CTV++ HR+ +L C LV+ KV ++D
Sbjct: 1300 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1357
Score = 250 bits (639), Expect = 6e-66
Identities = 180/642 (28%), Positives = 314/642 (48%), Gaps = 20/642 (3%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
PL+ A + S L SW P++ + R RL+ + I + D++D ++L R W+ E++ +
Sbjct: 85 PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRR 144
Query: 65 --KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIY 122
+ ++ + R R +F + + + P+L+ I Y EE+ +
Sbjct: 145 GIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS----EEQLGNVV 200
Query: 123 LGIGLCL-LFI---VRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
G+GLC LF+ V++L + ++ R A+ S ++K ++ S + I+ G
Sbjct: 201 HGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVI--HITSG 258
Query: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
+ +S + ++N EG+ V I + + + ++ +AF + +++
Sbjct: 259 EAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAV 318
Query: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
+ RM +K + + +R+ +TSE++ I+ +K Y WE+ K+IE+LR+ E KL K
Sbjct: 319 FMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEK 378
Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK-GIILRKIFTTISFCIVLRMAVTRQFPWA 357
V+ S F + VL + +K + F+ ++ +LR++V P A
Sbjct: 379 CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF-VPIA 437
Query: 358 VQTWYDSLGAINKIQDFLQKQEYKTLEYNLT--TTEVVMENVTAFWEEGFGELFEKAKQN 415
V+ +S A+ + + F ++ L + +V E T W++ + A +
Sbjct: 438 VKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALEL 497
Query: 416 NNNRKTSNG----DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471
N S G D+L P L IN + +G +L V G+TG+GK+SLL I
Sbjct: 498 ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557
Query: 472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDIS 531
+ E+ EG + G +++ Q +WI+ G I+ENI+ G +YD+ RY V+ C L D+
Sbjct: 558 LEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
Query: 532 KFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV 591
D +GE G+ LSGGQ+ RISLARAVY D +YLLD P +D K IFE C+
Sbjct: 618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI 677
Query: 592 CKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
K + KT +LVT ++++L+ +I++L G GT SEL
Sbjct: 678 KKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSEL 719
Score = 90.5 bits (223), Expect = 1e-17
Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 21/263 (7%)
Query: 1221 EGGNAI---LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDS 1276
E GN++ L I+ +S G +G+ G TGSGKS+LLSA L ++ EG + + G
Sbjct: 518 EEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG----- 572
Query: 1277 ITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLD 1336
+ +PQ+ +I SG R+N+ + +V L +E P
Sbjct: 573 --------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM 624
Query: 1337 FVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADC 1395
+ + G LS G KQ + LAR+V S +I LLD+P + +D V I +K+
Sbjct: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684
Query: 1396 TVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH-RN 1454
TV+L H+++ + C Q +++E K+ + + +L+ ++ + Q I + ++
Sbjct: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744
Query: 1455 SSKCKSKPQI--AALKEETEEEV 1475
++K KP++ AL EE +
Sbjct: 745 TAKIAEKPKVESQALATSLEESL 767
Score = 66.2 bits (160), Expect = 2e-10
Identities = 51/203 (25%), Positives = 96/203 (47%), Gaps = 28/203 (13%)
Query: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
VL IN I +++ + G TG+GK+SL M + +EP G+I G
Sbjct: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRS 1216
Query: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
++S Q ++ GTI+ N+ + + + ++ L + ISKF +K + + E G
Sbjct: 1217 KLSVIPQDPVLLSGTIRFNLDPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGG 1276
Query: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTE-------KEIFESCVCKLMANKT 599
S G+R + +ARAV +++ + L+D +D+ T+ +E F+ C T
Sbjct: 1277 NFSVGERQLLCIARAVLRNSKIILIDEATASIDMETDTLIQRTIREAFQGC--------T 1328
Query: 600 RILVTSKMEHLKKADKILILHEG 622
+++ ++ + D IL++ G
Sbjct: 1329 VLVIAHRVTTVLNCDHILVMGNG 1351
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 279 bits (713), Expect = 2e-74
Identities = 159/532 (29%), Positives = 287/532 (53%), Gaps = 24/532 (4%)
Query: 909 STSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
+TS Y +G+ L M + + I +++LH +LH+ +++P S +T
Sbjct: 1007 NTSLRLGVYAALGILQGFLVM--LAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTP 1064
Query: 969 AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
+G ILN FSKDI ++D++L I + I + V+ P V +P+ V + +
Sbjct: 1065 SGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTL 1124
Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
++ ++ TS+QLK+LES RSPI++H ++ G +RA+ R FE + ++ + +
Sbjct: 1125 VQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYNRSRDFEIISDTKVDANQRS 1184
Query: 1089 WFLYLSTLRWFQMRIEMI--FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWA 1146
+ Y+ + RW + +E + V+ F A+ F I + G VG+ ++ ++ + L W
Sbjct: 1185 CYPYIISNRWLSIGVEFVGNCVVLFAAL-FAVIGRSSLNPGLVGLSVSYSLQVTFALNWM 1243
Query: 1147 VNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPS 1206
+ D++S + +V RV K Y + ++E S + + WP
Sbjct: 1244 IRMMSDLESNIVAVERV----------------KEYSKTETEAPWVVEGS--RPPEGWPP 1285
Query: 1207 GGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
G++ ++ + +Y G + +L ++S + G++VG++GRTG+GKS++ R+L +G
Sbjct: 1286 RGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKG 1345
Query: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLR 1325
EI+IDG++ I L R +IPQ +FSGT R NLDP+ +S+++IW + L
Sbjct: 1346 EIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGSYSEEDIWWALELSHLH 1405
Query: 1326 SVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIR 1385
+ + P LDF +GG LS G +QL+CLAR++L K++IL+LDE +A +D T +I+
Sbjct: 1406 TFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQ 1465
Query: 1386 RTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
T++ F CTV+ HR+ +++ + LV+++ V ++DS L+ R +F
Sbjct: 1466 ATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517
Score = 261 bits (667), Expect = 4e-69
Identities = 178/677 (26%), Positives = 314/677 (46%), Gaps = 72/677 (10%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE---- 60
P A +S+LFF W + GYR LE D++ + D + + ++L W ++
Sbjct: 208 PETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQT 267
Query: 61 ------LASKKN-----------------PKLINALRRCFFWRFMFYGIFLYLGEVTKAV 97
A KN P + AL F F+ F + ++ +
Sbjct: 268 ARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFI 327
Query: 98 QPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLF-IVRTLLLHPAIFGLHHIGMQMRIAM 156
P LL +I N S +L GL L ++++L+L + G++ R +
Sbjct: 328 NPQLLSILIRFIS--NPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGI 385
Query: 157 FSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIW 216
+IY+K L +++ V ++G++V+L+S + +F + + +W APLQ+ L + +W
Sbjct: 386 MGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLW 445
Query: 217 ELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYC 276
+ L S G+ F+++L + M ++ ++ R+ + SE++ I+ +K Y
Sbjct: 446 QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYA 505
Query: 277 WEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKG---IIL 333
WE + K +E +RQ EL+L R AAY+ + + S F V +++ Y + +
Sbjct: 506 WEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVYVYVDPNNVLDA 565
Query: 334 RKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTE-- 391
K F ++S +LR+ + P + + ++ +IQ FL ++E T
Sbjct: 566 EKAFVSVSLFNILRLPLN-MLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPG 624
Query: 392 --VVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIE 449
+ + + T W + P L ++ ++
Sbjct: 625 YAITIHSGTFTWAQDL--------------------------------PPTLHSLDIQVP 652
Query: 450 RGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFG 509
+G L+AV G G GK+SL+ ++GE+E EGK+ G +++ Q +WI T++EN++FG
Sbjct: 653 KGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGSVAYVPQQAWIQNCTLQENVLFG 712
Query: 510 VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLY 569
+ + RY+ ++AC L D+ D +GE GI LSGGQR R+SLARAVY DAD++
Sbjct: 713 KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIF 772
Query: 570 LLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKKADKILILHEGSSYFY 627
LLD P +D K IF+ + ++A KTR+LVT + L + D I++L +G
Sbjct: 773 LLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEM 832
Query: 628 GTFSELQNLQPDFSSKL 644
G + L F++ L
Sbjct: 833 GPYPALLQRNGSFANFL 849
Score = 71.6 bits (174), Expect = 5e-12
Identities = 112/539 (20%), Positives = 210/539 (38%), Gaps = 91/539 (16%)
Query: 113 NKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVL 172
N + +Y +G+ F+V + A G+ R+ +L++ K ++
Sbjct: 1006 NNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQ----AARVLHQALLHNK-IRSPQSFF 1060
Query: 173 DKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALL---MGLIWELLQASAFCGLGF 229
D G++++ S ++ DE LA P+ + LL I L+ A L
Sbjct: 1061 DTTPSGRILNCFSKDIYVVDEVLA--------PVILMLLNSFFNAISTLVVIMASTPLFT 1112
Query: 230 LIVLAL---------FQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEA 280
+++L L F A R + + I SE + ++AY
Sbjct: 1113 VVILPLAVLYTLVQRFYAATSRQLKRLESVSRSPIYSHF---SETVTGASVIRAY----N 1165
Query: 281 MEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTT- 339
+ E + T++ +++ Y Y S+ + G V V+ +A + +I R
Sbjct: 1166 RSRDFEIISDTKVDANQRSCYP-YIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPG 1224
Query: 340 -ISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVT 398
+ + + VT W ++ D I ++ + EY+ T TE
Sbjct: 1225 LVGLSVSYSLQVTFALNWMIRMMSDLESNIVAVE--------RVKEYSKTETEAPWVVEG 1276
Query: 399 AFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTP----VLKDINFKIERGQLL 454
+ EG+ E + F N+S+ P VL+D++ + G+ +
Sbjct: 1277 SRPPEGWPPRGE-----------------VEFRNYSVRYRPGLDLVLRDLSLHVHGGEKV 1319
Query: 455 AVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-------------RISFCSQFSWIMPGT 501
+ G TGAGK+S+ + + LE ++G+I+ G +++ Q + GT
Sbjct: 1320 GIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGT 1379
Query: 502 IKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARA 561
++ N+ SY E ++ L +S + EGG LS GQR + LARA
Sbjct: 1380 LRMNLDPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARA 1439
Query: 562 VYKDADLYLLDSPFGYLDVLTEKEI-------FESCVCKLMANK-------TRILVTSK 606
+ + + + +LD +D+ T+ I F++C +A++ TR+LV K
Sbjct: 1440 LLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDK 1498
Score = 65.1 bits (157), Expect = 5e-10
Identities = 73/302 (24%), Positives = 134/302 (44%), Gaps = 28/302 (9%)
Query: 1148 NSSIDVDSLMRSVSRVFKFIDMPTEGKP------TKSTKPYKNGQ--LSKVMIIENSHVK 1199
N+ +D + SVS +F + +P P T+++ K Q LS+ + S V+
Sbjct: 560 NNVLDAEKAFVSVS-LFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQS-VE 617
Query: 1200 KDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL- 1258
+ I P G +T+ T + + L ++ + G V ++G G GKS+L+SA L
Sbjct: 618 RKTISP-GYAITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLG 676
Query: 1259 RLLNTEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKV 1318
+ EG++ + G + +PQ+ +I + T ++N+ + + + +
Sbjct: 677 EMEKLEGKVHMKG-------------SVAYVPQQAWIQNCTLQENVLFGKALNPKRYQQT 723
Query: 1319 ADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP 1378
+ L + +E PG + + G LS G +Q + LAR+V S A I LLD+P + +D
Sbjct: 724 LEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDS 783
Query: 1379 -VTYQIIRRTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
V I + + A T +L H I + + +V+ + +V + LL
Sbjct: 784 HVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNG 843
Query: 1436 LF 1437
F
Sbjct: 844 SF 845
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 276 bits (706), Expect = 1e-73
Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)
Query: 917 YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
Y +G++ + G+ + + L S+ LH +LHS+L++PMS +G ++NRF
Sbjct: 963 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1020
Query: 977 SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
SK++ +D ++P I F+ L VIGA V+ + P + P+ + + ++ +++ +
Sbjct: 1021 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1080
Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
S+QLK+LES RSP+++H +L G+ +RAF Q F ++ + ++ +
Sbjct: 1081 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1140
Query: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
RW +R+E + I A F I G VG+ ++ ++ + + L W V S ++++
Sbjct: 1141 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1200
Query: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
+ +V R+ ++ + E + T P + WP G++ ++
Sbjct: 1201 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1241
Query: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
+Y E + +L +I+ +I+ G++VG++GRTG+GKS+L R+ + EGEI IDG++
Sbjct: 1242 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1301
Query: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
I L R +IPQ +FSG+ R NLDP+ Q+SD+E+W + L+ + P
Sbjct: 1302 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1361
Query: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
KLD +GG LS G +QL+CLAR++L K KIL+LDE +A +D T +I+ T++ F
Sbjct: 1362 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1421
Query: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
DCTV+ HR+ +++ + +V+++ ++++Y + LL +R LF
Sbjct: 1422 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1465
Score = 184 bits (468), Expect = 4e-46
Identities = 153/707 (21%), Positives = 281/707 (39%), Gaps = 138/707 (19%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
P AS +S++ F W ++ +GYRQ LE SD++ + D+++ + L + W +E A
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268
Query: 65 K----------------------------------------NPKLINALRRCFFWRFMFY 84
+ NP L L + F F+
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 85 GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
F + ++ P +L +++ + D K + + L + ++TL+LH
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387
Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
GM+++ A+ +Y+K L +++ ++G++V+L+S + +F + + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447
Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
PLQV L + L+W L S G+ ++++ A + Y+ R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507
Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
++ I+ +K Y WE A + + +RQ ELK+ +K+AY+ + + + F V +
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567
Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
Y I + + F +++ +LR + P + + + ++ +++ FL +E
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
+ ++ T + + N T W
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656
Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
P L I F I G L+AV G G GK+SLL ++ E++ EG + G +++ Q
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQ 714
Query: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
+WI +++ENI+FG +E YRSVI+AC L D+ L G R
Sbjct: 715 AWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLE---------------ILPSGDRT 759
Query: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKAD 614
I KTRILVT M +L + D
Sbjct: 760 EIG---------------------------------------EKTRILVTHSMSYLPQVD 780
Query: 615 KILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
I+++ G G++ EL F+ L S +Q N +
Sbjct: 781 VIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 827
Score = 72.4 bits (176), Expect = 3e-12
Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)
Query: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
VL+ IN I G+ + + G TGAGK+SL + + E +EG+I G
Sbjct: 1253 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1312
Query: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
+I+ Q + G+++ N+ Y + + ++ L++ +S +K + EGG
Sbjct: 1313 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1372
Query: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
LS GQR + LARA+ + + +LD +D+ T+ ++ +S + + T + + +
Sbjct: 1373 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1431
Query: 607 MEHLKKADKILILHEGSSYFYGTFSEL 633
+ + ++++L +G YG S+L
Sbjct: 1432 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1458
Score = 47.4 bits (111), Expect = 1e-04
Identities = 32/115 (27%), Positives = 57/115 (49%), Gaps = 16/115 (13%)
Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
+E +++ + GG +TV++ T + L I+FSI G V ++G+ G GK
Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684
Query: 1251 STLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNL 1304
S+LLSA L ++ EG + I G + +PQ+ +I + + R+N+
Sbjct: 685 SSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENI 726
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 276 bits (706), Expect = 1e-73
Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)
Query: 917 YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
Y +G++ + G+ + + L S+ LH +LHS+L++PMS +G ++NRF
Sbjct: 904 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 961
Query: 977 SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
SK++ +D ++P I F+ L VIGA V+ + P + P+ + + ++ +++ +
Sbjct: 962 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1021
Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
S+QLK+LES RSP+++H +L G+ +RAF Q F ++ + ++ +
Sbjct: 1022 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1081
Query: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
RW +R+E + I A F I G VG+ ++ ++ + + L W V S ++++
Sbjct: 1082 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1141
Query: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
+ +V R+ ++ + E + T P + WP G++ ++
Sbjct: 1142 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1182
Query: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
+Y E + +L +I+ +I+ G++VG++GRTG+GKS+L R+ + EGEI IDG++
Sbjct: 1183 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1242
Query: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
I L R +IPQ +FSG+ R NLDP+ Q+SD+E+W + L+ + P
Sbjct: 1243 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1302
Query: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
KLD +GG LS G +QL+CLAR++L K KIL+LDE +A +D T +I+ T++ F
Sbjct: 1303 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1362
Query: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
DCTV+ HR+ +++ + +V+++ ++++Y + LL +R LF
Sbjct: 1363 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1406
Score = 142 bits (359), Expect = 2e-33
Identities = 113/543 (20%), Positives = 222/543 (40%), Gaps = 84/543 (15%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
P AS +S++ F W ++ +GYRQ LE SD++ + D+++ + L + W +E A
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268
Query: 65 K----------------------------------------NPKLINALRRCFFWRFMFY 84
+ NP L L + F F+
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 85 GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
F + ++ P +L +++ + D K + + L + ++TL+LH
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387
Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
GM+++ A+ +Y+K L +++ ++G++V+L+S + +F + + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447
Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
PLQV L + L+W L S G+ ++++ A + Y+ R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507
Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
++ I+ +K Y WE A + + +RQ ELK+ +K+AY+ + + + F V +
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567
Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
Y I + + F +++ +LR + P + + + ++ +++ FL +E
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPL-NILPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
+ ++ T + + N T W
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656
Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
P L I F I G L+AV G G GK+SLL ++ E++ EG + RI
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSM 714
Query: 495 SWI 497
S++
Sbjct: 715 SYL 717
Score = 72.4 bits (176), Expect = 3e-12
Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)
Query: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
VL+ IN I G+ + + G TGAGK+SL + + E +EG+I G
Sbjct: 1194 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1253
Query: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
+I+ Q + G+++ N+ Y + + ++ L++ +S +K + EGG
Sbjct: 1254 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1313
Query: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
LS GQR + LARA+ + + +LD +D+ T+ ++ +S + + T + + +
Sbjct: 1314 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1372
Query: 607 MEHLKKADKILILHEGSSYFYGTFSEL 633
+ + ++++L +G YG S+L
Sbjct: 1373 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1399
Score = 42.4 bits (98), Expect = 0.003
Identities = 26/80 (32%), Positives = 43/80 (53%), Gaps = 3/80 (3%)
Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
+E +++ + GG +TV++ T + L I+FSI G V ++G+ G GK
Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684
Query: 1251 STLLSAFLRLLN-TEGEIQI 1269
S+LLSA L ++ EG + I
Sbjct: 685 SSLLSALLAEMDKVEGHVAI 704
Score = 33.9 bits (76), Expect = 1.2
Identities = 21/67 (31%), Positives = 32/67 (47%)
Query: 595 MANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFS 654
+A KTRILVT M +L + D I+++ G G++ EL F+ L S +Q
Sbjct: 702 VAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQ 761
Query: 655 AERRNSI 661
N +
Sbjct: 762 DAEENGV 768
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 276 bits (706), Expect = 1e-73
Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)
Query: 917 YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
Y +G++ + G+ + + L S+ LH +LHS+L++PMS +G ++NRF
Sbjct: 960 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1017
Query: 977 SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
SK++ +D ++P I F+ L VIGA V+ + P + P+ + + ++ +++ +
Sbjct: 1018 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1077
Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
S+QLK+LES RSP+++H +L G+ +RAF Q F ++ + ++ +
Sbjct: 1078 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1137
Query: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
RW +R+E + I A F I G VG+ ++ ++ + + L W V S ++++
Sbjct: 1138 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1197
Query: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
+ +V R+ ++ + E + T P + WP G++ ++
Sbjct: 1198 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1238
Query: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
+Y E + +L +I+ +I+ G++VG++GRTG+GKS+L R+ + EGEI IDG++
Sbjct: 1239 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1298
Query: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
I L R +IPQ +FSG+ R NLDP+ Q+SD+E+W + L+ + P
Sbjct: 1299 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1358
Query: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
KLD +GG LS G +QL+CLAR++L K KIL+LDE +A +D T +I+ T++ F
Sbjct: 1359 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1418
Query: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
DCTV+ HR+ +++ + +V+++ ++++Y + LL +R LF
Sbjct: 1419 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1462
Score = 150 bits (380), Expect = 7e-36
Identities = 146/709 (20%), Positives = 274/709 (38%), Gaps = 145/709 (20%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
P AS +S++ F W ++ +GYRQ LE SD++ + D+++ + L + W +E A
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268
Query: 65 K----------------------------------------NPKLINALRRCFFWRFMFY 84
+ NP L L + F F+
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 85 GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
F + ++ P +L +++ + D K + + L + ++TL+LH
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387
Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
GM+++ A+ +Y+K L +++ ++G++V+L+S + +F + + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447
Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
PLQV L + L+W L S G+ ++++ A + Y+ R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507
Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
++ I+ +K Y WE A + + +RQ ELK+ +K+AY+ + + + F V +
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567
Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
Y I + + F +++ +LR + P + + + ++ +++ FL +E
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPL-NILPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
+ ++ T + + N T W
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656
Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
P L I F I G L+AV G G GK+SLL ++ E++ EG + G
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKG-------- 706
Query: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
+S + + S+ +A DI F
Sbjct: 707 -------------VNLSGGQKQRVSLARAVYSNADIYLF--------------------- 732
Query: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKK 612
D L +D+ G K IFE+ + ++ NKTRILVT M +L +
Sbjct: 733 ----------DDPLSAVDAHVG-------KHIFENVIGPKGMLKNKTRILVTHSMSYLPQ 775
Query: 613 ADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
D I+++ G G++ EL F+ L S +Q N +
Sbjct: 776 VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 824
Score = 72.4 bits (176), Expect = 3e-12
Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)
Query: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
VL+ IN I G+ + + G TGAGK+SL + + E +EG+I G
Sbjct: 1250 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1309
Query: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
+I+ Q + G+++ N+ Y + + ++ L++ +S +K + EGG
Sbjct: 1310 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1369
Query: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
LS GQR + LARA+ + + +LD +D+ T+ ++ +S + + T + + +
Sbjct: 1370 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1428
Query: 607 MEHLKKADKILILHEGSSYFYGTFSEL 633
+ + ++++L +G YG S+L
Sbjct: 1429 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1455
Score = 46.2 bits (108), Expect = 2e-04
Identities = 28/84 (33%), Positives = 46/84 (54%), Gaps = 3/84 (3%)
Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
+E +++ + GG +TV++ T + L I+FSI G V ++G+ G GK
Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684
Query: 1251 STLLSAFLRLLN-TEGEIQIDGVS 1273
S+LLSA L ++ EG + I GV+
Sbjct: 685 SSLLSALLAEMDKVEGHVAIKGVN 708
Score = 40.8 bits (94), Expect = 0.010
Identities = 31/100 (31%), Positives = 47/100 (47%), Gaps = 3/100 (3%)
Query: 1343 GCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTL--KQAFADCTVIL 1399
G LS G KQ + LAR+V S A I L D+P + +D V I + K + T IL
Sbjct: 706 GVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRIL 765
Query: 1400 CEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQ 1439
H + + + +V+ K+ + S Q+LL F +
Sbjct: 766 VTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAE 805
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 276 bits (706), Expect = 1e-73
Identities = 159/524 (30%), Positives = 287/524 (54%), Gaps = 24/524 (4%)
Query: 917 YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
Y +G++ + G+ + + L S+ LH +LHS+L++PMS +G ++NRF
Sbjct: 1019 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1076
Query: 977 SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
SK++ +D ++P I F+ L VIGA V+ + P + P+ + + ++ +++ +
Sbjct: 1077 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1136
Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
S+QLK+LES RSP+++H +L G+ +RAF Q F ++ + ++ +
Sbjct: 1137 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1196
Query: 1097 RWFQMRIEMIF-VIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
RW +R+E + I A F I G VG+ ++ ++ + + L W V S ++++
Sbjct: 1197 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1256
Query: 1156 LMRSVSRVFKFIDMPTEGK-PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKD 1214
+ +V R+ ++ + E + T P + WP G++ ++
Sbjct: 1257 NIVAVERLKEYSETEKEAPWQIQETAPPSS-------------------WPQVGRVEFRN 1297
Query: 1215 LTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVS 1273
+Y E + +L +I+ +I+ G++VG++GRTG+GKS+L R+ + EGEI IDG++
Sbjct: 1298 YCLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGIN 1357
Query: 1274 WDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPG 1333
I L R +IPQ +FSG+ R NLDP+ Q+SD+E+W + L+ + P
Sbjct: 1358 IAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPD 1417
Query: 1334 KLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFA 1393
KLD +GG LS G +QL+CLAR++L K KIL+LDE +A +D T +I+ T++ F
Sbjct: 1418 KLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFE 1477
Query: 1394 DCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
DCTV+ HR+ +++ + +V+++ ++++Y + LL +R LF
Sbjct: 1478 DCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLF 1521
Score = 259 bits (662), Expect = 1e-68
Identities = 178/709 (25%), Positives = 317/709 (44%), Gaps = 86/709 (12%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
P AS +S++ F W ++ +GYRQ LE SD++ + D+++ + L + W +E A
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268
Query: 65 K----------------------------------------NPKLINALRRCFFWRFMFY 84
+ NP L L + F F+
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 85 GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
F + ++ P +L +++ + D K + + L + ++TL+LH
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387
Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
GM+++ A+ +Y+K L +++ ++G++V+L+S + +F + + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447
Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
PLQV L + L+W L S G+ ++++ A + Y+ R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507
Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
++ I+ +K Y WE A + + +RQ ELK+ +K+AY+ + + + F V +
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567
Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
Y I + + F +++ +LR + P + + + ++ +++ FL +E
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
+ ++ T + + N T W
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656
Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
P L I F I G L+AV G G GK+SLL ++ E++ EG + G +++ Q
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQ 714
Query: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
+WI +++ENI+FG +E YRSVI+AC L D+ D +GE G+ LSGGQ+
Sbjct: 715 AWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQ 774
Query: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKK 612
R+SLARAVY +AD+YL D P +D K IFE+ + ++ NKTRILVT M +L +
Sbjct: 775 RVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQ 834
Query: 613 ADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
D I+++ G G++ EL F+ L S +Q N +
Sbjct: 835 VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 883
Score = 75.9 bits (185), Expect = 3e-13
Identities = 68/253 (26%), Positives = 113/253 (44%), Gaps = 19/253 (7%)
Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
+E +++ + GG +TV++ T + L I+FSI G V ++G+ G GK
Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684
Query: 1251 STLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQ 1309
S+LLSA L ++ EG + I G + +PQ+ +I + + R+N+ Q
Sbjct: 685 SSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQ 731
Query: 1310 WSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLL 1369
+ V L +E P + + G LS G KQ + LAR+V S A I L
Sbjct: 732 LEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLF 791
Query: 1370 DEPSAHLDP-VTYQIIRRTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDS 1426
D+P + +D V I + K + T IL H + + + +V+ K+ + S
Sbjct: 792 DDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGS 851
Query: 1427 IQKLLNERSLFRQ 1439
Q+LL F +
Sbjct: 852 YQELLARDGAFAE 864
Score = 72.4 bits (176), Expect = 3e-12
Identities = 51/207 (24%), Positives = 100/207 (48%), Gaps = 14/207 (6%)
Query: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
VL+ IN I G+ + + G TGAGK+SL + + E +EG+I G
Sbjct: 1309 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1368
Query: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
+I+ Q + G+++ N+ Y + + ++ L++ +S +K + EGG
Sbjct: 1369 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1428
Query: 547 TLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSK 606
LS GQR + LARA+ + + +LD +D+ T+ ++ +S + + T + + +
Sbjct: 1429 NLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETD-DLIQSTIRTQFEDCTVLTIAHR 1487
Query: 607 MEHLKKADKILILHEGSSYFYGTFSEL 633
+ + ++++L +G YG S+L
Sbjct: 1488 LNTIMDYTRVIVLDKGEIQEYGAPSDL 1514
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 266 bits (680), Expect = 1e-70
Identities = 170/546 (31%), Positives = 291/546 (53%), Gaps = 33/546 (6%)
Query: 911 SSYYVFY--IYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLK 968
SS FY +Y +A R + + + LH ++LH VL AP++ N
Sbjct: 933 SSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATP 992
Query: 969 AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIM 1028
G ILNRFS D+A DD LP + + ++G +AV+ P++ + P+ + +
Sbjct: 993 TGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYH 1052
Query: 1029 LRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTAN 1088
++ ++ +S++L++L S SP+++HL +L GL LRA G FE + L L+
Sbjct: 1053 VQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRC 1112
Query: 1089 WFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEG---EGRVGIILTLAMNIMSTLQW 1145
F +T++W +R++++ A+ I+++ +G G VG+ L+ A+++ L
Sbjct: 1113 QFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSG 1172
Query: 1146 AVNSSIDVDSLMRSVSRVFKF-IDMPTE--GKPTKSTKPYKNGQLSKVMIIENSHVKKDD 1202
V+S ++++ SV R+ ++ D+P E G+P ++
Sbjct: 1173 LVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQP----------------------LQLGT 1210
Query: 1203 IWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN 1262
W + G + +D+ Y G L+ ++F + PG+++G++GRTGSGKS+LL RLL
Sbjct: 1211 GWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLE 1270
Query: 1263 -TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADE 1321
+ G + +DGV + L Q R +IPQ+ F+FSGT R+NLDP D+ +W+ +
Sbjct: 1271 PSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQ 1330
Query: 1322 VGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTY 1381
L VI G LD L +GG LS G +QL+CLAR++L+ AKIL +DE +A +D T
Sbjct: 1331 CHLSEVITSM-GGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTD 1389
Query: 1382 QIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNE-RSLFRQA 1440
Q++++T+ + FA+ TV+ HR+ +L + LV++ +V + DS L N+ SLF+Q
Sbjct: 1390 QLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQL 1449
Query: 1441 ISPSDR 1446
+ S +
Sbjct: 1450 LQSSQQ 1455
Score = 210 bits (535), Expect = 7e-54
Identities = 157/637 (24%), Positives = 298/637 (46%), Gaps = 42/637 (6%)
Query: 10 SVVSKLFFSWTRPILRKGYRQRL-ELSDIYQIPSVDSADNLSEKLEREWDRELASKKNPK 68
S +S+ ++W P+L +G L + DI ++P L+ + W ++ +
Sbjct: 176 SWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHW------QEGAR 229
Query: 69 LINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLC 128
L AL F ++ G+ +G + PLLL ++ + + +E S + +GL
Sbjct: 230 LWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLE-EGQEPLSHGLLYALGLA 288
Query: 129 LLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNL 188
++ +L + + ++ + +Q R A+ +++Y K L+L + G+ ++LL +
Sbjct: 289 GGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGP---SRPPTGEALNLLGTDS 345
Query: 189 NKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYR 248
+ H W PLQ+A+ + L+++ + + GL ++L + +M
Sbjct: 346 ERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASN 405
Query: 249 DQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSS 308
+ R+ + +E++ I+ +K WE+A+ +E R EL R ++Y +++
Sbjct: 406 QEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLR---VIKYLDAA 462
Query: 309 AFFFSGFFVVFLSV---LPYALI-KGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDS 364
+ V +S+ + Y L+ + K+FT ++ +L + + FPW + ++
Sbjct: 463 CVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPLNN-FPWVINGLLEA 521
Query: 365 LGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNG 424
++++IQ FL + N A++ G L + K + +
Sbjct: 522 KVSLDRIQLFLDLPNH---------------NPQAYYSPDCGRLGAQIKWLLCSDPPAEP 566
Query: 425 DDSLFFSNFSLLGTPVLKDI-----NFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSE 479
L PV + + ++++G L+ + G G GK+SLL I GEL
Sbjct: 567 STVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLR 626
Query: 480 GKIKHSGR---ISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEK 536
G + G +Q WI TI++NI+FG ++D Y+ V++AC L +D+S
Sbjct: 627 GHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAG 686
Query: 537 DNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMA 596
D +GE G+TLSGGQRARI+LARAVY++ +LYLLD P +D + C+ +++
Sbjct: 687 DQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLS 746
Query: 597 NKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
TR+L T + E+L++AD +L++ G G SE+
Sbjct: 747 YTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEI 783
Score = 99.0 bits (245), Expect = 3e-20
Identities = 59/195 (30%), Positives = 102/195 (52%), Gaps = 15/195 (7%)
Query: 441 LKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG-------------R 487
L + F ++ G+ L + G TG+GK+SLL+V+ LEPS G++ G +
Sbjct: 1235 LDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQ 1294
Query: 488 ISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGIT 547
++ Q ++ GT++EN+ + + +K C L E I+ D LGEGG +
Sbjct: 1295 LAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDG-ELGEGGRS 1353
Query: 548 LSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKM 607
LS GQR + LARA+ DA + +D +D T+ ++ + +CK ANKT + + ++
Sbjct: 1354 LSLGQRQLLCLARALLTDAKILCIDEATASVDQKTD-QLLQQTICKRFANKTVLTIAHRL 1412
Query: 608 EHLKKADKILILHEG 622
+ +D++L+L G
Sbjct: 1413 NTILNSDRVLVLQAG 1427
Score = 73.9 bits (180), Expect = 1e-12
Identities = 98/443 (22%), Positives = 178/443 (40%), Gaps = 37/443 (8%)
Query: 987 LPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESE 1046
LPL + + LL +G V ++ + V VI IM ++Q++ Q +
Sbjct: 361 LPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMA------SNQEMLQ-HKD 413
Query: 1047 GRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFH--KALNLHTANWFLYLSTL---RWFQM 1101
R + T L L G+ ++ G + +A L YL W +
Sbjct: 414 ARVKLVTEL---LSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAAL 470
Query: 1102 RIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVS 1161
+ + VIF V LT + + ++ L + + + W +N ++ S+
Sbjct: 471 PVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPL-NNFPWVINGLLEAKV---SLD 526
Query: 1162 RVFKFIDMPTEGKPTK-STKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYT 1220
R+ F+D+P S + G K ++ + + + G + D
Sbjct: 527 RIQLFLDLPNHNPQAYYSPDCGRLGAQIKWLLCSDPPAEPSTVLELHGALFSWDPVGTSL 586
Query: 1221 EGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQIDGVSWDSITL 1279
E + LE + G VG++G+ G GKS+LL+A L G + + G+S
Sbjct: 587 ETFISHLE-----VKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLS------ 635
Query: 1280 QQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVL 1339
K FG+ Q+ +I T R N+ + + Q +V + L + P +
Sbjct: 636 ----KGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEV 691
Query: 1340 VDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLD-PVTYQIIRRTLKQAFADCTVI 1398
+ G LS G + + LAR+V + ++ LLD+P A +D V ++ R + + T +
Sbjct: 692 GEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRL 751
Query: 1399 LCEHRIEAMLECQQFLVIEENKV 1421
LC HR E + L++E ++
Sbjct: 752 LCTHRTEYLERADAVLLMEAGRL 774
>gi|134142335 ATP-binding cassette, sub-family C, member 1 isoform 5
[Homo sapiens]
Length = 1466
Score = 259 bits (662), Expect = 1e-68
Identities = 178/709 (25%), Positives = 317/709 (44%), Gaps = 86/709 (12%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
P AS +S++ F W ++ +GYRQ LE SD++ + D+++ + L + W +E A
Sbjct: 209 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKT 268
Query: 65 K----------------------------------------NPKLINALRRCFFWRFMFY 84
+ NP L L + F F+
Sbjct: 269 RKQPVKVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMS 328
Query: 85 GIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFG 144
F + ++ P +L +++ + D K + + L + ++TL+LH
Sbjct: 329 FFFKAIHDLMMFSGPQIL-KLLIKFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHI 387
Query: 145 LHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIA 204
GM+++ A+ +Y+K L +++ ++G++V+L+S + +F + + +W A
Sbjct: 388 CFVSGMRIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSA 447
Query: 205 PLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSE 264
PLQV L + L+W L S G+ ++++ A + Y+ R+ + +E
Sbjct: 448 PLQVILALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNE 507
Query: 265 MIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLP 324
++ I+ +K Y WE A + + +RQ ELK+ +K+AY+ + + + F V +
Sbjct: 508 ILNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAV 567
Query: 325 YALIKG---IILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY- 380
Y I + + F +++ +LR + P + + + ++ +++ FL +E
Sbjct: 568 YVTIDENNILDAQTAFVSLALFNILRFPLNI-LPMVISSIVQASVSLKRLRIFLSHEELE 626
Query: 381 ------KTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFS 434
+ ++ T + + N T W
Sbjct: 627 PDSIERRPVKDGGGTNSITVRNATFTWARS------------------------------ 656
Query: 435 LLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQF 494
P L I F I G L+AV G G GK+SLL ++ E++ EG + G +++ Q
Sbjct: 657 --DPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQQ 714
Query: 495 SWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRA 554
+WI +++ENI+FG +E YRSVI+AC L D+ D +GE G+ LSGGQ+
Sbjct: 715 AWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQ 774
Query: 555 RISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKK 612
R+SLARAVY +AD+YL D P +D K IFE+ + ++ NKTRILVT M +L +
Sbjct: 775 RVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQ 834
Query: 613 ADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSI 661
D I+++ G G++ EL F+ L S +Q N +
Sbjct: 835 VDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGV 883
Score = 204 bits (519), Expect = 5e-52
Identities = 122/429 (28%), Positives = 224/429 (52%), Gaps = 22/429 (5%)
Query: 917 YIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRF 976
Y +G++ + G+ + + L S+ LH +LHS+L++PMS +G ++NRF
Sbjct: 1019 YGALGISQGIAVFGYSMAVSIGGIL--ASRCLHVDLLHSILRSPMSFFERTPSGNLVNRF 1076
Query: 977 SKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQT 1036
SK++ +D ++P I F+ L VIGA V+ + P + P+ + + ++ +++ +
Sbjct: 1077 SKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVAS 1136
Query: 1037 SQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTL 1096
S+QLK+LES RSP+++H +L G+ +RAF Q F ++ + ++ +
Sbjct: 1137 SRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVAN 1196
Query: 1097 RWFQMRIEMI-FVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDS 1155
RW +R+E + I A F I G VG+ ++ ++ + + L W V S ++++
Sbjct: 1197 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMET 1256
Query: 1156 LMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDL 1215
+ +V R+ ++ + T+ P+ + WP G++ ++
Sbjct: 1257 NIVAVERLKEYSE-------TEKEAPW-----------QIQETAPPSSWPQVGRVEFRNY 1298
Query: 1216 TAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL-LNTEGEIQIDGVSW 1274
+Y E + +L +I+ +I+ G++VG++GRTG+GKS+L R+ + EGEI IDG++
Sbjct: 1299 CLRYREDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINI 1358
Query: 1275 DSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
I L R +IPQ +FSG+ R NLDP+ Q+SD+E+W + L+ + P K
Sbjct: 1359 AKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDK 1418
Query: 1335 LDFVLVDGG 1343
LD +GG
Sbjct: 1419 LDHECAEGG 1427
Score = 75.9 bits (185), Expect = 3e-13
Identities = 68/253 (26%), Positives = 113/253 (44%), Gaps = 19/253 (7%)
Query: 1193 IENSHVKKDDIWPSGG--QMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGK 1250
+E +++ + GG +TV++ T + L I+FSI G V ++G+ G GK
Sbjct: 625 LEPDSIERRPVKDGGGTNSITVRNATFTWARSDPPTLNGITFSIPEGALVAVVGQVGCGK 684
Query: 1251 STLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQ 1309
S+LLSA L ++ EG + I G + +PQ+ +I + + R+N+ Q
Sbjct: 685 SSLLSALLAEMDKVEGHVAIKG-------------SVAYVPQQAWIQNDSLRENILFGCQ 731
Query: 1310 WSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLL 1369
+ V L +E P + + G LS G KQ + LAR+V S A I L
Sbjct: 732 LEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLF 791
Query: 1370 DEPSAHLDP-VTYQIIRRTL--KQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDS 1426
D+P + +D V I + K + T IL H + + + +V+ K+ + S
Sbjct: 792 DDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGS 851
Query: 1427 IQKLLNERSLFRQ 1439
Q+LL F +
Sbjct: 852 YQELLARDGAFAE 864
Score = 41.6 bits (96), Expect = 0.006
Identities = 31/122 (25%), Positives = 56/122 (45%), Gaps = 13/122 (10%)
Query: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------------- 486
VL+ IN I G+ + + G TGAGK+SL + + E +EG+I G
Sbjct: 1309 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1368
Query: 487 RISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGI 546
+I+ Q + G+++ N+ Y + + ++ L++ +S +K + EGG
Sbjct: 1369 KITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAEGGE 1428
Query: 547 TL 548
L
Sbjct: 1429 NL 1430
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 252 bits (644), Expect = 2e-66
Identities = 163/533 (30%), Positives = 272/533 (51%), Gaps = 27/533 (5%)
Query: 921 GVADTLLAMGFFRGLPLVHTL-ITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKD 979
G+ L A+G F + V S++L ++L V+++P+S G +LNRFSK+
Sbjct: 992 GLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKE 1051
Query: 980 IAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQ 1039
+D +P + + ++ VVAV P VA +P+ + + ++ ++ +S Q
Sbjct: 1052 TDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQ 1111
Query: 1040 LKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWF 1099
L++LES S + +H+ + +G +RAF Q F + ++ F L RW
Sbjct: 1112 LRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWL 1171
Query: 1100 QMRIEMIFVIFFIAVTFISILTTGE-GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMR 1158
+E++ A ++L+ G VG ++ A+ + TLQW V + D+++ +
Sbjct: 1172 AANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIV 1231
Query: 1159 SVSRVFKFIDMPTEGK---PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDL 1215
SV R+ + P E PT + +P WP GGQ+ +D
Sbjct: 1232 SVERMQDYAWTPKEAPWRLPTCAAQPP---------------------WPQGGQIEFRDF 1270
Query: 1216 TAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVSW 1274
+Y ++ +SF I G++VG++GRTG+GKS+L S LRL EG I IDGV
Sbjct: 1271 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1330
Query: 1275 DSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
+ L R +IPQ +F G+ R NLD ++ SD+ IW + V L++++ PG+
Sbjct: 1331 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQ 1390
Query: 1335 LDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFAD 1394
L + D G LS G KQL+CLAR++L K +IL+LDE +A +DP T ++ L FA
Sbjct: 1391 LQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQ 1450
Query: 1395 CTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRV 1447
CTV+L HR+ ++++C + LV+++ +V + S +LL ++ LF + S V
Sbjct: 1451 CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1503
Score = 219 bits (558), Expect = 2e-56
Identities = 165/668 (24%), Positives = 307/668 (45%), Gaps = 70/668 (10%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL-AS 63
P A+ SK F W ++ +GYR+ L D++ + +S++ L +LE+EW R A+
Sbjct: 204 PETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 263
Query: 64 KKNPK------------------------------LINALRRCFFWRFMFYGIFLYLGEV 93
+++ K L+ A+ + F F+ + L + +V
Sbjct: 264 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDV 323
Query: 94 TKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMR 153
+ P LL + + D K L + + L ++TL ++ L + M++R
Sbjct: 324 FRFTVPKLLS-LFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLR 382
Query: 154 IAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMG 213
A+ L+Y+K L LSS ++G +V+L+S ++ + E + + +W+ + + +
Sbjct: 383 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 442
Query: 214 LIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVK 273
+W+LL SA + + L + + +++++ + R +TS ++ N +++K
Sbjct: 443 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIK 502
Query: 274 AYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALI--KGI 331
+ WE A + +R EL R + + + +F S F V + + L+ +
Sbjct: 503 FHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 562
Query: 332 ILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTE 391
K F T++ +L A P+++ + + + +++ FL +E
Sbjct: 563 NAEKAFVTLTVLNILNKAQAF-LPFSIHSLVQARVSFDRLVTFLCLEEV----------- 610
Query: 392 VVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN----FSLLGTPVLKDINFK 447
+ ++++ ++ G D + + +S P L IN
Sbjct: 611 ------------------DPGVVDSSSSGSAAGKDCITIHSATFAWSQESPPCLHRINLT 652
Query: 448 IERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENII 507
+ +G LLAV G GAGK+SLL ++GEL EG + G +++ Q +W+ ++ EN+
Sbjct: 653 VPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVC 712
Query: 508 FGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDAD 567
FG D V++AC L+ D+ F E + +GE G+ LSGGQ+ R+SLARAVY+ A
Sbjct: 713 FGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAA 772
Query: 568 LYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKKADKILILHEGSSY 625
+YLLD P LD + +F + L+ TRILVT + L +AD I++L G+
Sbjct: 773 VYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIA 832
Query: 626 FYGTFSEL 633
G++ EL
Sbjct: 833 EMGSYQEL 840
Score = 79.3 bits (194), Expect = 2e-14
Identities = 63/245 (25%), Positives = 113/245 (46%), Gaps = 21/245 (8%)
Query: 1210 MTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQ 1268
+T+ T +++ L I+ ++ G + ++G G+GKS+LLSA L L EG +
Sbjct: 629 ITIHSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 688
Query: 1269 IDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVI 1328
I+G A +PQ+ ++ + + +N+ ++ + +V + L+ +
Sbjct: 689 IEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 735
Query: 1329 EQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRT 1387
+ FP + + + G LS G KQ + LAR+V KA + LLD+P A LD V + +
Sbjct: 736 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 795
Query: 1388 LKQA--FADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS----LFRQAI 1441
+ T IL H + + + +V+ + + S Q+LL + L QA
Sbjct: 796 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQAR 855
Query: 1442 SPSDR 1446
P DR
Sbjct: 856 QPGDR 860
Score = 70.1 bits (170), Expect = 2e-11
Identities = 68/314 (21%), Positives = 133/314 (42%), Gaps = 49/314 (15%)
Query: 340 ISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQEYKTLEYNLTTTEVVMEN 396
+ F + + VT+ W V+ W D S+ ++ ++QD+ K + L T
Sbjct: 1202 VGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP--KEAPWRLPTCAAQPP- 1258
Query: 397 VTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVL----KDINFKIERGQ 452
W +G + F +F L P L + ++FKI G+
Sbjct: 1259 ----WPQG---------------------GQIEFRDFGLRYRPELPLAVQGVSFKIHAGE 1293
Query: 453 LLAVAGSTGAGKTSLLMVIMGELEPSEG-------KIKHSG------RISFCSQFSWIMP 499
+ + G TGAGK+SL ++ E +EG I H G RIS Q + P
Sbjct: 1294 KVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFP 1353
Query: 500 GTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLA 559
G+++ N+ + + + ++ QL+ ++ + + G LS GQ+ + LA
Sbjct: 1354 GSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLA 1413
Query: 560 RAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILIL 619
RA+ + + +LD +D TE ++ ++ + A T +L+ ++ + ++L++
Sbjct: 1414 RALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVM 1472
Query: 620 HEGSSYFYGTFSEL 633
+G G+ ++L
Sbjct: 1473 DKGQVAESGSPAQL 1486
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 252 bits (643), Expect = 2e-66
Identities = 163/533 (30%), Positives = 272/533 (51%), Gaps = 27/533 (5%)
Query: 921 GVADTLLAMGFFRGLPLVHTL-ITVSKILHHKMLHSVLQAPMSTLNTLKAGGILNRFSKD 979
G+ L A+G F + V S++L ++L V+++P+S G +LNRFSK+
Sbjct: 801 GLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKE 860
Query: 980 IAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQ 1039
+D +P + + ++ VVAV P VA +P+ + + ++ ++ +S Q
Sbjct: 861 TDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSSCQ 920
Query: 1040 LKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWF 1099
L++LES S + +H+ + +G +RAF Q F + ++ F L RW
Sbjct: 921 LRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADRWL 980
Query: 1100 QMRIEMIFVIFFIAVTFISILTTGE-GEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMR 1158
+E++ A ++L+ G VG ++ A+ + TLQW V + D+++ +
Sbjct: 981 AANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIV 1040
Query: 1159 SVSRVFKFIDMPTEGK---PTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDL 1215
SV R+ + P E PT + +P WP GGQ+ +D
Sbjct: 1041 SVERMQDYAWTPKEAPWRLPTCAAQPP---------------------WPQGGQIEFQDF 1079
Query: 1216 TAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVSW 1274
+Y ++ +SF I G++VG++GRTG+GKS+L S LRL EG I IDGV
Sbjct: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139
Query: 1275 DSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
+ L R +IPQ +F G+ R NLD ++ SD+ IW + V L++++ PG+
Sbjct: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQ 1199
Query: 1335 LDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFAD 1394
L + D G LS G KQL+CLAR++L K +IL+LDE +A +DP T ++ L FA
Sbjct: 1200 LQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQ 1259
Query: 1395 CTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRV 1447
CTV+L HR+ ++++C + LV+++ +V + S +LL ++ LF + S V
Sbjct: 1260 CTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGLV 1312
Score = 220 bits (560), Expect = 9e-57
Identities = 165/668 (24%), Positives = 307/668 (45%), Gaps = 70/668 (10%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDREL-AS 63
P A+ SK F W ++ +GYR+ L D++ + +S++ L +LE+EW R A+
Sbjct: 13 PETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 72
Query: 64 KKNPK------------------------------LINALRRCFFWRFMFYGIFLYLGEV 93
+++ K L+ A+ + F F+ + L + +V
Sbjct: 73 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAIWQVFHSTFLLGTLSLIISDV 132
Query: 94 TKAVQPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMR 153
+ P LL + + D K L + + L ++TL ++ L + M++R
Sbjct: 133 FRFTVPKLLS-LFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLR 191
Query: 154 IAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMG 213
A+ L+Y+K L LSS ++G +V+L+S ++ + E + + +W+ + + +
Sbjct: 192 SAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFV 251
Query: 214 LIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVK 273
+W+LL SA + + L + + +++++ + R +TS ++ N +++K
Sbjct: 252 YLWQLLGPSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIK 311
Query: 274 AYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALI--KGI 331
+ WE A + +R EL R + + + +F S F V + + L+ +
Sbjct: 312 FHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAM 371
Query: 332 ILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTE 391
K F T++ +L A P+++ + + + +++ FL +E
Sbjct: 372 NAEKAFVTLTVLNILNKAQAF-LPFSIHSLVQARVSFDRLVTFLCLEEV----------- 419
Query: 392 VVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN----FSLLGTPVLKDINFK 447
+ ++++ ++ G D + + +S P L IN
Sbjct: 420 ------------------DPGAVDSSSSGSAAGKDCITIQSATFAWSQESPPCLHRINLT 461
Query: 448 IERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENII 507
+ +G LLAV G GAGK+SLL ++GEL EG + G +++ Q +W+ ++ EN+
Sbjct: 462 VPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVC 521
Query: 508 FGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDAD 567
FG D V++AC L+ D+ F E + +GE G+ LSGGQ+ R+SLARAVY+ A
Sbjct: 522 FGQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAA 581
Query: 568 LYLLDSPFGYLDVLTEKEIFESCVCK--LMANKTRILVTSKMEHLKKADKILILHEGSSY 625
+YLLD P LD + +F + L+ TRILVT + L +AD I++L G+
Sbjct: 582 VYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIA 641
Query: 626 FYGTFSEL 633
G++ EL
Sbjct: 642 EMGSYQEL 649
Score = 80.1 bits (196), Expect = 1e-14
Identities = 63/245 (25%), Positives = 114/245 (46%), Gaps = 21/245 (8%)
Query: 1210 MTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL-RLLNTEGEIQ 1268
+T++ T +++ L I+ ++ G + ++G G+GKS+LLSA L L EG +
Sbjct: 438 ITIQSATFAWSQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVS 497
Query: 1269 IDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVI 1328
I+G A +PQ+ ++ + + +N+ ++ + +V + L+ +
Sbjct: 498 IEG-------------AVAYVPQEAWVQNTSVVENVCFGQELDPPWLERVLEACALQPDV 544
Query: 1329 EQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRT 1387
+ FP + + + G LS G KQ + LAR+V KA + LLD+P A LD V + +
Sbjct: 545 DSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQV 604
Query: 1388 LKQA--FADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS----LFRQAI 1441
+ T IL H + + + +V+ + + S Q+LL + L QA
Sbjct: 605 IGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLDQAR 664
Query: 1442 SPSDR 1446
P DR
Sbjct: 665 QPGDR 669
Score = 70.5 bits (171), Expect = 1e-11
Identities = 68/314 (21%), Positives = 133/314 (42%), Gaps = 49/314 (15%)
Query: 340 ISFCIVLRMAVTRQFPWAVQTWYD---SLGAINKIQDFLQKQEYKTLEYNLTTTEVVMEN 396
+ F + + VT+ W V+ W D S+ ++ ++QD+ K + L T
Sbjct: 1011 VGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTP--KEAPWRLPTCAAQPP- 1067
Query: 397 VTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVL----KDINFKIERGQ 452
W +G + F +F L P L + ++FKI G+
Sbjct: 1068 ----WPQG---------------------GQIEFQDFGLRYRPELPLAVQGVSFKIHAGE 1102
Query: 453 LLAVAGSTGAGKTSLLMVIMGELEPSEG-------KIKHSG------RISFCSQFSWIMP 499
+ + G TGAGK+SL ++ E +EG I H G RIS Q + P
Sbjct: 1103 KVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFP 1162
Query: 500 GTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLA 559
G+++ N+ + + + ++ QL+ ++ + + G LS GQ+ + LA
Sbjct: 1163 GSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLA 1222
Query: 560 RAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILIL 619
RA+ + + +LD +D TE ++ ++ + A T +L+ ++ + ++L++
Sbjct: 1223 RALLRKTQILILDEATAAVDPGTELQM-QAMLGSWFAQCTVLLIAHRLRSVMDCARVLVM 1281
Query: 620 HEGSSYFYGTFSEL 633
+G G+ ++L
Sbjct: 1282 DKGQVAESGSPAQL 1295
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 250 bits (639), Expect = 6e-66
Identities = 180/642 (28%), Positives = 314/642 (48%), Gaps = 20/642 (3%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRELASK 64
PL+ A + S L SW P++ + R RL+ + I + D++D ++L R W+ E++ +
Sbjct: 85 PLDNAGLFSYLTVSWLTPLMIQSLRSRLDENTIPPLSVHDASDKNVQRLHRLWEEEVSRR 144
Query: 65 --KNPKLINALRRCFFWRFMFYGIFLYLGEVTKAVQPLLLGRIIASYDPDNKEERSIAIY 122
+ ++ + R R +F + + + P+L+ I Y EE+ +
Sbjct: 145 GIEKASVLLVMLRFQRTRLIFDALLGICFCIASVLGPILIIPKILEYS----EEQLGNVV 200
Query: 123 LGIGLCL-LFI---VRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIG 178
G+GLC LF+ V++L + ++ R A+ S ++K ++ S + I+ G
Sbjct: 201 HGVGLCFALFLSECVKSLSFSSSWIINQRTAIRFRAAVSSFAFEKLIQFKSVI--HITSG 258
Query: 179 QLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQA 238
+ +S + ++N EG+ V I + + + ++ +AF + +++
Sbjct: 259 EAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYTAFIAILCYLLVFPLAV 318
Query: 239 GLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
+ RM +K + + +R+ +TSE++ I+ +K Y WE+ K+IE+LR+ E KL K
Sbjct: 319 FMTRMAVKAQHHTSEVSDQRIRVTSEVLTCIKLIKMYTWEKPFAKIIEDLRRKERKLLEK 378
Query: 299 AAYVRYFNSSAFFFSGFFVVFLSVLPYALIK-GIILRKIFTTISFCIVLRMAVTRQFPWA 357
V+ S F + VL + +K + F+ ++ +LR++V P A
Sbjct: 379 CGLVQSLTSITLFIIPTVATAVWVLIHTSLKLKLTASMAFSMLASLNLLRLSVFF-VPIA 437
Query: 358 VQTWYDSLGAINKIQDFLQKQEYKTLEYNLT--TTEVVMENVTAFWEEGFGELFEKAKQN 415
V+ +S A+ + + F ++ L + +V E T W++ + A +
Sbjct: 438 VKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATLSWQQTCPGIVNGALEL 497
Query: 416 NNNRKTSNG----DDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVI 471
N S G D+L P L IN + +G +L V G+TG+GK+SLL I
Sbjct: 498 ERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAI 557
Query: 472 MGELEPSEGKIKHSGRISFCSQFSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDIS 531
+ E+ EG + G +++ Q +WI+ G I+ENI+ G +YD+ RY V+ C L D+
Sbjct: 558 LEEMHLLEGSVGVQGSLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLE 617
Query: 532 KFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCV 591
D +GE G+ LSGGQ+ RISLARAVY D +YLLD P +D K IFE C+
Sbjct: 618 LLPFGDMTEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECI 677
Query: 592 CKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
K + KT +LVT ++++L+ +I++L G GT SEL
Sbjct: 678 KKTLRGKTVVLVTHQLQYLEFCGQIILLENGKICENGTHSEL 719
Score = 233 bits (595), Expect = 8e-61
Identities = 174/658 (26%), Positives = 302/658 (45%), Gaps = 82/658 (12%)
Query: 781 QNIHRKTTAS----TRKVSLAPQANLTELDIYSRRLSQETGLEISEEINEEDLKECFFDD 836
Q +H++ T+ T K++ P+ SQ + E +N + E
Sbjct: 731 QKMHKEATSDMLQDTAKIAEKPKVE-----------SQALATSLEESLNGNAVPEHQLTQ 779
Query: 837 MESIPAVT-TWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVL--WLLGNTPLQDKG 893
E + + +W Y YI ++ C++ F + L + W L Q G
Sbjct: 780 EEEMEEGSLSWRVYHHYIQAAGGY---MVSCIIFFFVVLIVFLTIFSFWWLSYWLEQGSG 836
Query: 894 -NSTHSRNNSYAVI--ITSTSSYYVFYIYVGV-ADTLLAMGFFRGLPLVHTLITVSKILH 949
NS+ N + A + I + + G+ A L+ +G S LH
Sbjct: 837 TNSSRESNGTMADLGNIADNPQLSFYQLVYGLNALLLICVGVCSSGIFTKVTRKASTALH 896
Query: 950 HKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVA 1009
+K+ + V + PMS +T+ G +LN F+ D+ LD LLP+ F+ L L+VI + +V+
Sbjct: 897 NKLFNKVFRCPMSFFDTIPIGRLLNCFAGDLEQLDQLLPIFSEQFLVLSLMVIAVLLIVS 956
Query: 1010 VLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFG 1069
VL PYI + ++V + F + K+LE+ RSP+F+H++ SL+GL ++ +G
Sbjct: 957 VLSPYILLMGAIIMVICFIYYMMFKKAIGVFKRLENYSRSPLFSHILNSLQGLSSIHVYG 1016
Query: 1070 RQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT-FISILTTGEGEGR 1128
+ F + F + + L+LS+ RW +R+E++ + +AV F++ +
Sbjct: 1017 KTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPYSF 1076
Query: 1129 VGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLS 1188
+ + + + + S+ Q ++ ++ +V R+ +++ M P
Sbjct: 1077 KVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAP------------- 1123
Query: 1189 KVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGS 1248
+ +E + + WP G++ +D KY + +L I+ +I + VG++GRTGS
Sbjct: 1124 --LHMEGTSCPQG--WPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGS 1179
Query: 1249 GKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPY 1307
GKS+L A RL+ G I IDGV SI L+ R VIPQ + SGT R NLDP+
Sbjct: 1180 GKSSLGMALFRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPF 1239
Query: 1308 EQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKIL 1367
++ +DQ+IW L R+ L+KA I+
Sbjct: 1240 DRHTDQQIWD-------------------------------------ALERTFLTKA-II 1261
Query: 1368 LLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYD 1425
L+DE +A +D T +I+RT+++AF CTV++ HR+ +L C LV+ KV ++D
Sbjct: 1262 LIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFD 1319
Score = 90.5 bits (223), Expect = 1e-17
Identities = 72/263 (27%), Positives = 126/263 (47%), Gaps = 21/263 (7%)
Query: 1221 EGGNAI---LENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDS 1276
E GN++ L I+ +S G +G+ G TGSGKS+LLSA L ++ EG + + G
Sbjct: 518 EEGNSLGPELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQG----- 572
Query: 1277 ITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWSDQEIWKVADEVGLRSVIEQFPGKLD 1336
+ +PQ+ +I SG R+N+ + +V L +E P
Sbjct: 573 --------SLAYVPQQAWIVSGNIRENILMGGAYDKARYLQVLHCCSLNRDLELLPFGDM 624
Query: 1337 FVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDP-VTYQIIRRTLKQAFADC 1395
+ + G LS G KQ + LAR+V S +I LLD+P + +D V I +K+
Sbjct: 625 TEIGERGLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGK 684
Query: 1396 TVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPH-RN 1454
TV+L H+++ + C Q +++E K+ + + +L+ ++ + Q I + ++
Sbjct: 685 TVVLVTHQLQYLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQD 744
Query: 1455 SSKCKSKPQI--AALKEETEEEV 1475
++K KP++ AL EE +
Sbjct: 745 TAKIAEKPKVESQALATSLEESL 767
Score = 37.4 bits (85), Expect = 0.11
Identities = 20/53 (37%), Positives = 30/53 (56%), Gaps = 1/53 (1%)
Query: 440 VLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGRISFCS 492
VL IN I +++ + G TG+GK+SL M + +EP G+I G + CS
Sbjct: 1157 VLHGINLTIRGHEVVGIVGRTGSGKSSLGMALFRLVEPMAGRILIDG-VDICS 1208
>gi|221316556 ATP-binding cassette, sub-family C, member 3 isoform 2
[Homo sapiens]
Length = 572
Score = 117 bits (293), Expect = 8e-26
Identities = 84/341 (24%), Positives = 155/341 (45%), Gaps = 30/341 (8%)
Query: 5 PLEKASVVSKLFFSWTRPILRKGYRQRLELSDIYQIPSVDSADNLSEKLEREWDRE---- 60
P A +S+LFF W + GYR LE D++ + D + + ++L W ++
Sbjct: 208 PETSAGFLSRLFFWWFTKMAIYGYRHPLEEKDLWSLKEEDRSQMVVQQLLEAWRKQEKQT 267
Query: 61 ------LASKKN-----------------PKLINALRRCFFWRFMFYGIFLYLGEVTKAV 97
A KN P + AL F F+ F + ++ +
Sbjct: 268 ARHKASAAPGKNASGEDEVLLGARPRPRKPSFLKALLATFGSSFLISACFKLIQDLLSFI 327
Query: 98 QPLLLGRIIASYDPDNKEERSIAIYLGIGLCLLF-IVRTLLLHPAIFGLHHIGMQMRIAM 156
P LL +I N S +L GL L ++++L+L + G++ R +
Sbjct: 328 NPQLLSILIRFIS--NPMAPSWWGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGI 385
Query: 157 FSLIYKKTLKLSSRVLDKISIGQLVSLLSNNLNKFDEGLALAHFVWIAPLQVALLMGLIW 216
+IY+K L +++ V ++G++V+L+S + +F + + +W APLQ+ L + +W
Sbjct: 386 MGVIYRKALVITNSVKRASTVGEIVNLMSVDAQRFMDLAPFLNLLWSAPLQIILAIYFLW 445
Query: 217 ELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYC 276
+ L S G+ F+++L + M ++ ++ R+ + SE++ I+ +K Y
Sbjct: 446 QNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYA 505
Query: 277 WEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFV 317
WE + K +E +RQ EL+L R AAY+ + + S F V
Sbjct: 506 WEPSFLKQVEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLV 546
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 115 bits (289), Expect = 2e-25
Identities = 149/611 (24%), Positives = 264/611 (43%), Gaps = 106/611 (17%)
Query: 78 FWRFMF-------YGIFLYLGEVTKAVQ-PLLLGR---IIASYDPDN-----KEERSIAI 121
FW+F+ + L LG VQ PLLLG+ ++A Y D+ E ++++
Sbjct: 120 FWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLST 179
Query: 122 YLGIGLCLLFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLV 181
+L +L+ V+ LL + L H+G +M + M ++ L+ D GQLV
Sbjct: 180 HL----LILYGVQGLLTFGYLVLLSHVGERMAVDMRRALFSSLLRQDITFFDANKTGQLV 235
Query: 182 SLLSNNLNKF--------DEGLALAHFVWIAPLQVALLMGLIWELLQAS--AFCGLGFLI 231
S L+ ++ +F +GL V + +++L + LL + A G+G
Sbjct: 236 SRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVG--- 292
Query: 232 VLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEAMEKMIENLRQT 291
L +GL ++ + ++Q I+ + + E + N+++V+A+ AME+ E
Sbjct: 293 --TLMGSGLRKLSRQCQEQ----IARAMGVADEALGNVRTVRAF----AMEQREEERYGA 342
Query: 292 ELKLTRKAAYVRYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISF-CIVLRMAV 350
EL+ R A L +GI L + + I+F C+VL
Sbjct: 343 ELEACRCRAE------------------------ELGRGIALFQGLSNIAFNCMVLG--- 375
Query: 351 TRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFE 410
T ++ G + FL + T++ ++ V+ V G +FE
Sbjct: 376 TLFIGGSLVAGQQLTGG--DLMSFLVASQ--TVQRSMANLSVLFGQVVRGLSAG-ARVFE 430
Query: 411 KAKQN------------NNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAG 458
N + S ++ FS G VLKD + G+++A+ G
Sbjct: 431 YMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVG 490
Query: 459 STGAGKTSLLMVIMGELEPSEGKIKHSGR--------------ISFCSQFSWIMPGTIKE 504
+G GKT++ ++ +P+ G + GR + F SQ + TI E
Sbjct: 491 QSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIME 550
Query: 505 NIIFGV--SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAV 562
NI FG + DE Y + +A E I+ F E N V+GE G TLSGGQ+ R+++ARA+
Sbjct: 551 NIRFGKLEASDEEVYTAAREA-NAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARAL 609
Query: 563 YKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEG 622
K + +LD LD +E+ + + + + A +T +++ ++ ++ A I+++ +G
Sbjct: 610 IKQPTVLILDEATSALDAESER-VVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADG 668
Query: 623 SSYFYGTFSEL 633
+ GT EL
Sbjct: 669 RVWEAGTHEEL 679
Score = 102 bits (254), Expect = 3e-21
Identities = 131/628 (20%), Positives = 270/628 (42%), Gaps = 45/628 (7%)
Query: 846 WNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTHSRNNSYAV 905
W + +++ H + VL +V+ L ++ + LLG ++ T S+
Sbjct: 117 WKLFWQFLHPH---LLVLGVAVVLALGAALVNVQIPLLLGQL-VEVVAKYTRDHVGSFMT 172
Query: 906 IITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVLQAPMSTLN 965
+ S++ + I GV LL G+ L V + V + + S+L+ ++ +
Sbjct: 173 ESQNLSTHLL--ILYGVQG-LLTFGYLVLLSHVGERMAVD--MRRALFSSLLRQDITFFD 227
Query: 966 TLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPYIFVATVPVIVA 1025
K G +++R + D+ L I ++ V G + +++L + T+ ++VA
Sbjct: 228 ANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRL---TLLLMVA 284
Query: 1026 FIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTS---LKGLWTLRAFGRQPYFETLFHKAL 1082
L L++L + + I + + L + T+RAF + E + L
Sbjct: 285 TPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAEL 344
Query: 1083 NLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGIILTLAMNIMST 1142
+ FQ + F + FI + G +++ + +
Sbjct: 345 EACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTV 404
Query: 1143 LQWAVNSSIDVDSLMRSVS---RVFKFIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVK 1199
+ N S+ ++R +S RVF+++ + P G V
Sbjct: 405 QRSMANLSVLFGQVVRGLSAGARVFEYMAL-------NPCIPLSGGCC----------VP 447
Query: 1200 KDDIWPSGGQMTVKDLTAKYT-EGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFL 1258
K+ + G +T +++ Y G +L++ + ++ PG+ V L+G++G GK+T+ S
Sbjct: 448 KEQL---RGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLE 504
Query: 1259 RLLN-TEGEIQIDGVSWDSITLQQWR-KAFGVIPQKVFIFSGTFRKNLDPYE-QWSDQEI 1315
R + T G + +DG ++ R + G I Q+ +F T +N+ + + SD+E+
Sbjct: 505 RFYDPTAGVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEV 564
Query: 1316 WKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAH 1375
+ A E I FP + V+ + G LS G KQ + +AR+++ + +L+LDE ++
Sbjct: 565 YTAAREANAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSA 624
Query: 1376 LDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
LD + ++++ L +A A TV++ HR+ + +V+ + +V + + ++LL +
Sbjct: 625 LDAESERVVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGG 684
Query: 1436 LFRQAISPSDRVKLFPHRNSSKCKSKPQ 1463
L+ + I R L R ++ KP+
Sbjct: 685 LYAELIR---RQALDAPRTAAPPPKKPE 709
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 115 bits (289), Expect = 2e-25
Identities = 108/436 (24%), Positives = 193/436 (44%), Gaps = 45/436 (10%)
Query: 1056 VTSLKGLWTLRAFGRQPYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVT 1115
+ SL T++ F + Y + L + STL IF + A+
Sbjct: 335 IDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIM 394
Query: 1116 FIS-------ILTTGEGEGRVGII--LTLAMNIMSTLQWAVNSS-IDVDSLMRSVSRVFK 1165
++ LT G+ G++ L+L +N + T+ + ID+++L F
Sbjct: 395 VLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTL-------FT 447
Query: 1166 FIDMPTEGKPTKSTKPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNA 1225
+ + T+ K P + + + +N H + Y EG
Sbjct: 448 LLKVDTQIKDKVMASPLQITPQTATVAFDNVHFE-------------------YIEG-QK 487
Query: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTE-GEIQIDGVSWDSITLQQWRK 1284
+L ISF + G++V ++G +GSGKST++ R + G I + G + ++L+ R+
Sbjct: 488 VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRR 547
Query: 1285 AFGVIPQKVFIFSGTFRKNLDPYE-QWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
A GV+PQ +F T NL S +E++ VA GL I + P D + + G
Sbjct: 548 AVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERG 607
Query: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
LS G KQ + +AR++L ++L DE ++ LD +T + I +K T I HR
Sbjct: 608 LKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHR 667
Query: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLL-NERSLFRQA-ISPSDRVKLFPHRNSSKCKSK 1461
+ +++ + +V+++ KV + + LL N S++ + + S RV+ H N K
Sbjct: 668 LSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSRVQ--NHDNPKWEAKK 725
Query: 1462 PQIAALKEETEEEVQD 1477
I+ KEE +++Q+
Sbjct: 726 ENIS--KEEERKKLQE 739
Score = 88.2 bits (217), Expect = 5e-17
Identities = 55/207 (26%), Positives = 107/207 (51%), Gaps = 15/207 (7%)
Query: 437 GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR--------- 487
G VL I+F++ G+ +A+ G +G+GK++++ ++ EP +G I +G+
Sbjct: 485 GQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLES 544
Query: 488 ----ISFCSQFSWIMPGTIKENIIFG-VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLG 542
+ Q + + TI N+++G +S +V K L + I + + +G
Sbjct: 545 LRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVG 604
Query: 543 EGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRIL 602
E G+ LSGG++ R+++ARA+ KD + L D LD +TE+ I + ++ ++T I
Sbjct: 605 ERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETIL-GAMKDVVKHRTSIF 663
Query: 603 VTSKMEHLKKADKILILHEGSSYFYGT 629
+ ++ + AD+I++L +G GT
Sbjct: 664 IAHRLSTVVDADEIIVLDQGKVAERGT 690
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 111 bits (277), Expect = 6e-24
Identities = 130/625 (20%), Positives = 272/625 (43%), Gaps = 62/625 (9%)
Query: 838 ESIPAVTTWNTYLRYITVHKSLIFVLIWCLVIFLAEVAASLVVLWLLGNTPLQDKGNSTH 897
ESIP V+ W +T + + ++ + A +++ ++G D +
Sbjct: 690 ESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKR 749
Query: 898 SRNNSYAVIITSTSSYYVFYIYVGVADTLLAMGFFRGLPLVHTLITVSKILHHKMLHSVL 957
+N ++++ ++ +G+ + F +G ++K L + + S+L
Sbjct: 750 QNSNLFSLL----------FLALGIISFITF--FLQGFTFGKAGEILTKRLRYMVFRSML 797
Query: 958 QAPMSTLNTLK--AGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAVVAVLQPY- 1014
+ +S + K G + R + D A + + + Q + +G +++ + +
Sbjct: 798 RQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIAN-LGTGIIISFIYGWQ 856
Query: 1015 ---IFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQ 1071
+ +A VP+I ++ L + E EG I T + + + T+ + ++
Sbjct: 857 LTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFR---TVVSLTQE 913
Query: 1072 PYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVGI 1131
FE ++ ++L + N +R IF I F + T + + G R G
Sbjct: 914 QKFEHMYAQSLQVPYRN-----------SLRKAHIFGITF-SFTQAMMYFSYAGCFRFGA 961
Query: 1132 ILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKPYKNGQLSK-- 1189
L +A +MS D L+ + VF + + G+ + Y ++S
Sbjct: 962 YL-VAHKLMSF----------EDVLLVFSAVVFGAMAV---GQVSSFAPDYAKAKISAAH 1007
Query: 1190 -VMIIENSHV----KKDDIWPSG--GQMTVKDLTAKY-TEGGNAILENISFSISPGQRVG 1241
+MIIE + + + + P+ G +T ++ Y T +L+ +S + GQ +
Sbjct: 1008 IIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA 1067
Query: 1242 LLGRTGSGKSTLLSAFLRLLNT-EGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTF 1300
L+G +G GKST++ R + G++ +DG + +Q R G++ Q+ +F +
Sbjct: 1068 LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSI 1127
Query: 1301 RKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLA 1357
+N+ D S +EI + A E + + IE P K + D G LS G KQ + +A
Sbjct: 1128 AENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIA 1187
Query: 1358 RSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIE 1417
R+++ + ILLLDE ++ LD + ++++ L +A T I+ HR+ + +V +
Sbjct: 1188 RALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQ 1247
Query: 1418 ENKVRQYDSIQKLLNERSLFRQAIS 1442
+V+++ + Q+LL ++ ++ +S
Sbjct: 1248 NGRVKEHGTHQQLLAQKGIYFSMVS 1272
Score = 100 bits (250), Expect = 8e-21
Identities = 67/250 (26%), Positives = 127/250 (50%), Gaps = 3/250 (1%)
Query: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRK 1284
IL+ ++ + GQ V L+G +G GKST + RL + TEG + +DG +I ++ R+
Sbjct: 409 ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLRE 468
Query: 1285 AFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGG 1343
GV+ Q+ +F+ T +N+ E + EI K E I + P K D ++ + G
Sbjct: 469 IIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERG 528
Query: 1344 CVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHR 1403
LS G KQ + +AR+++ KILLLDE ++ LD + +++ L +A T I+ HR
Sbjct: 529 AQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHR 588
Query: 1404 IEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSDRVKLFPHRNSSKCKSKPQ 1463
+ + ++ + + + +L+ E+ ++ + ++ N++ +SK +
Sbjct: 589 LSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAAD-ESKSE 647
Query: 1464 IAALKEETEE 1473
I AL+ + +
Sbjct: 648 IDALEMSSND 657
Score = 97.1 bits (240), Expect = 1e-19
Identities = 120/563 (21%), Positives = 246/563 (43%), Gaps = 86/563 (15%)
Query: 173 DKISIGQLVSLLSNNLNKFDEGLALA---HFVWIAPLQVALLMGLI--WELLQASAFCGL 227
D +G+L + L+++++K +EG+ F +A ++G W+L L
Sbjct: 164 DVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVI----L 219
Query: 228 GFLIVLALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWEEA-MEKMIE 286
VL L A +++ + D+ ++ + E++ I++V A+ ++ +E+ +
Sbjct: 220 AISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNK 279
Query: 287 NLRQTELKLTRKAAYVRYFNSSAFF--FSGFFVVFLSVLPYALIKGIILRKIFTTISFCI 344
NL + + +KA +AF ++ + + F L + ++ T +
Sbjct: 280 NLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVL 339
Query: 345 VLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEG 404
+ +V + P +++ + ++ GA +I +K +++N +
Sbjct: 340 IGAFSVGQASP-SIEAFANARGAAYEI--------FK-----------IIDNKPSI---- 375
Query: 405 FGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGK 464
+ + K+ +N K + ++ FS S +LK +N K++ GQ +A+ G++G GK
Sbjct: 376 --DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGK 433
Query: 465 TSLLMVIMGELEPSEGKIKHSGR-------------ISFCSQFSWIMPGTIKENIIFG-- 509
++ + ++ +P+EG + G+ I SQ + TI ENI +G
Sbjct: 434 STTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRE 493
Query: 510 -VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDADL 568
V+ DE +K + I K K + ++GE G LSGGQ+ RI++ARA+ ++ +
Sbjct: 494 NVTMDEIE--KAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKI 551
Query: 569 YLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKIL----------- 617
LLD LD +E + + + K +T I++ ++ ++ AD I
Sbjct: 552 LLLDEATSALDTESE-AVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKG 610
Query: 618 ----ILHEGSSYF-------YGTFSELQNLQPDFSSKLMGCDSFDQFSAERRNSILTETL 666
++ E YF G EL+N + S++ D+ + S + R+S++ +
Sbjct: 611 NHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEI---DALEMSSNDSRSSLIRKRS 667
Query: 667 HRFSLEGDAPVSWTETKKQSFKQ 689
R S+ G S + +K S K+
Sbjct: 668 TRRSVRG----SQAQDRKLSTKE 686
Score = 97.1 bits (240), Expect = 1e-19
Identities = 146/663 (22%), Positives = 282/663 (42%), Gaps = 116/663 (17%)
Query: 36 DIYQIPSVDSADNLSEKLE--------REWDRELASKKNPKLINALRRCFFWRFM----- 82
D ++ S DS +L K + DR+L++K+ L ++ FWR M
Sbjct: 649 DALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKE--ALDESIPPVSFWRIMKLNLT 706
Query: 83 ---FYGIFLYLGEVTKAVQP---LLLGRIIASY----DPDNKEERS---IAIYLGIGLCL 129
++ + ++ + +QP ++ +II + DP+ K + S ++L +G+ +
Sbjct: 707 EWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGI-I 765
Query: 130 LFIVRTLLLHPAIFGLHHIGMQMRIAMFSLIYKKTLKLSSRVLD--KISIGQLVSLLSNN 187
FI T L FG G + + ++++ L+ D K + G L + L+N+
Sbjct: 766 SFI--TFFLQGFTFG--KAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAND 821
Query: 188 LNKFDEGLALAHFVW---IAPLQVALLMGLI--WELLQASAFCGLGFLIVLALFQAGLGR 242
+ + V IA L +++ I W+L L+ + A G
Sbjct: 822 AAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTL--------LLLAIVPIIAIAGV 873
Query: 243 MMMKYRDQRAGKISERLV----ITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRK 298
+ MK +A K + L I +E IEN ++V + E+ E M Q + + +
Sbjct: 874 VEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLR 933
Query: 299 AAYV-----------RYFNSSAFFFSGFFVVFLSVLPYALIKGIILRKIFTTISFCIVLR 347
A++ YF+ + F G ++V ++ + + ++L +F+ + F +
Sbjct: 934 KAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSF---EDVLL--VFSAVVFGAMAV 988
Query: 348 MAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGE 407
V+ P + + I I+ KT + +TE +M N T FGE
Sbjct: 989 GQVSSFAPDYAKAKISAAHIIMIIE--------KTPLIDSYSTEGLMPN-TLEGNVTFGE 1039
Query: 408 LFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSL 467
+ F+ + PVL+ ++ ++++GQ LA+ GS+G GK+++
Sbjct: 1040 VV--------------------FNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTV 1079
Query: 468 LMVIMGELEPSEGKIKHSGR-------------ISFCSQFSWIMPGTIKENIIFGVSYDE 514
+ ++ +P GK+ G+ + SQ + +I ENI +G +
Sbjct: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
Query: 515 YRYRSVIKACQLEEDISKFAE----KDNIVLGEGGITLSGGQRARISLARAVYKDADLYL 570
+++A + E +I F E K + +G+ G LSGGQ+ RI++ARA+ + + L
Sbjct: 1140 VSQEEIVRAAK-EANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILL 1198
Query: 571 LDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTF 630
LD LD +EK + + + K +T I++ ++ ++ AD I++ G +GT
Sbjct: 1199 LDEATSALDTESEK-VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1257
Query: 631 SEL 633
+L
Sbjct: 1258 QQL 1260
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 108 bits (271), Expect = 3e-23
Identities = 101/478 (21%), Positives = 199/478 (41%), Gaps = 32/478 (6%)
Query: 968 KAGGILNRFSKDIAILDDLLPLTIFDFIQLLL-IVIGAIAVVAVLQPYIFVATVPVIVAF 1026
+ G +L + + + LL +F+ I L I+IG I + + + +
Sbjct: 365 RTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLY 424
Query: 1027 IMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRAFGRQPYFETLFHKALNLHT 1086
+ L + + ++ + + V SL T++ + + Y + +A+ +
Sbjct: 425 LTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAESYEVERYREAIIKYQ 484
Query: 1087 ANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTTGEGEGRVG---IILTLAMNIMSTL 1143
+ ++L ++ + +A + + E + +VG + T + + L
Sbjct: 485 GLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPL 544
Query: 1144 QWAVNSSIDVDSLMRSVSRVFKFIDMPTEGKPTKSTKP--YKNGQLSKVMIIENSHVKKD 1201
W + + + +F + TE K P ++ G++ EN H
Sbjct: 545 NWFGTYYRMIQTNFIDMENMFDLLKEETEVKDLPGAGPLRFQKGRIE----FENVHFSYA 600
Query: 1202 DIWPSGGQMTVKDLTAKYTEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLL 1261
D G L+++SF++ PGQ + L+G +G+GKST+L R
Sbjct: 601 D--------------------GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFY 640
Query: 1262 N-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYEQWS-DQEIWKVA 1319
+ + G I+IDG +T R GV+PQ +F+ T N+ + + E+ A
Sbjct: 641 DISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAA 700
Query: 1320 DEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPV 1379
G+ I FP + + G LS G KQ + +AR++L I+LLDE ++ LD
Sbjct: 701 QAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTS 760
Query: 1380 TYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLF 1437
+ I+ +L + A+ T I+ HR+ ++ Q LVI++ + + + LL+ ++
Sbjct: 761 NERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVY 818
Score = 92.8 bits (229), Expect = 2e-18
Identities = 59/200 (29%), Positives = 105/200 (52%), Gaps = 15/200 (7%)
Query: 437 GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSGR--------- 487
G L+D++F + GQ LA+ G +GAGK+++L ++ + S G I+ G+
Sbjct: 602 GRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQAS 661
Query: 488 ----ISFCSQFSWIMPGTIKENIIFG-VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLG 542
I Q + + TI +NI +G V+ + +A + + I F E +G
Sbjct: 662 LRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVG 721
Query: 543 EGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRIL 602
E G+ LSGG++ R+++AR + K + LLD LD E+ I ++ + K+ AN+T I+
Sbjct: 722 ERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI-QASLAKVCANRTTIV 780
Query: 603 VTSKMEHLKKADKILILHEG 622
V ++ + AD+IL++ +G
Sbjct: 781 VAHRLSTVVNADQILVIKDG 800
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 107 bits (268), Expect = 7e-23
Identities = 65/221 (29%), Positives = 117/221 (52%), Gaps = 4/221 (1%)
Query: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRK 1284
IL +S SI G+ V +G +G GKST + RL + +G++ DGV + +Q R
Sbjct: 587 ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646
Query: 1285 AFGVIPQKVFIFSGTFRKNL---DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVD 1341
++PQ+ +F+ + +N+ D EI + A+ + S IE P K + +
Sbjct: 647 QIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGL 706
Query: 1342 GGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCE 1401
G LS G KQ + +AR++L K KILLLDE ++ LD + ++++ L +A T ++
Sbjct: 707 KGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVT 766
Query: 1402 HRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAIS 1442
HR+ A+ +V+ K+++ + Q+LL R ++ + ++
Sbjct: 767 HRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVN 807
Score = 97.8 bits (242), Expect = 7e-20
Identities = 97/399 (24%), Positives = 170/399 (42%), Gaps = 60/399 (15%)
Query: 261 ITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFVVFL 320
I +E +ENI+++ + E+A E+M E + QT+ + T K A + S + FS F+ F
Sbjct: 431 IATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQII---GSCYAFSHAFIYFA 487
Query: 321 SVLPYALIKGIILRKIFTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEY 380
+ +I T IV + GA+ + + EY
Sbjct: 488 YAAGFRFGAYLIQAGRMTPEGMFIVFTAI--------------AYGAMAIGETLVLAPEY 533
Query: 381 KTLEYNLTTTEVVME---NVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLL- 436
+ ++E N+ + +EG +K + +L F S
Sbjct: 534 SKAKSGAAHLFALLEKKPNIDSRSQEG--------------KKPDTCEGNLEFREVSFFY 579
Query: 437 ----GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------ 486
+L+ ++ IERG+ +A GS+G GK++ + ++ +P +G++ G
Sbjct: 580 PCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKEL 639
Query: 487 -------RISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKFA 534
+I+ Q + +I ENI +G V DE + A + I
Sbjct: 640 NVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIK--EAANAANIHSFIEGLP 697
Query: 535 EKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKL 594
EK N +G G LSGGQ+ R+++ARA+ + + LLD LD +EK + + + K
Sbjct: 698 EKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEK-VVQHALDKA 756
Query: 595 MANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
+T ++VT ++ ++ AD I++LH G GT EL
Sbjct: 757 RTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQEL 795
Score = 73.6 bits (179), Expect = 1e-12
Identities = 40/171 (23%), Positives = 88/171 (51%), Gaps = 1/171 (0%)
Query: 1276 SITLQQWRKAFGVIPQKVFIFSGTFRKNLD-PYEQWSDQEIWKVADEVGLRSVIEQFPGK 1334
++ ++ +R GV+ Q+ +F T N+ + +D+E+ + A E I +FP K
Sbjct: 9 ALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNK 68
Query: 1335 LDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFAD 1394
+ ++ + G +S G KQ + +AR+++ KIL+LDE ++ LD + ++ L++A
Sbjct: 69 FNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKG 128
Query: 1395 CTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAISPSD 1445
T I+ HR+ + + +++ + + + +L+ +R L+ + D
Sbjct: 129 RTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQD 179
Score = 61.2 bits (147), Expect = 7e-09
Identities = 48/163 (29%), Positives = 80/163 (49%), Gaps = 4/163 (2%)
Query: 488 ISFCSQFSWIMPGTIKENIIFGVS--YDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
I SQ + TI NI +G DE R+ +A + I +F K N ++GE G
Sbjct: 19 IGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREA-NAYDFIMEFPNKFNTLVGEKG 77
Query: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTS 605
+SGGQ+ RI++ARA+ ++ + +LD LD K ++ + K +T I+V
Sbjct: 78 AQMSGGQKQRIAIARALVRNPKILILDEATSALD-SESKSAVQAALEKASKGRTTIVVAH 136
Query: 606 KMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCD 648
++ ++ AD I+ L +G G +EL + + S +M D
Sbjct: 137 RLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQD 179
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 107 bits (268), Expect = 7e-23
Identities = 128/595 (21%), Positives = 241/595 (40%), Gaps = 67/595 (11%)
Query: 87 FLYLGEVTKAVQPLLLGRII-ASYDPDNKEERSIAIYLGIGLCLLFIVRTLLLHPAIFGL 145
FL + V P LG+II Y + L +GL +F+ ++ +
Sbjct: 177 FLTMSSVISMSAPFFLGKIIDVIYTNPTVDYSDNLTRLCLGLSAVFLCGAAANAIRVYLM 236
Query: 146 HHIGMQMRIAMFSLIYKKTLKLSSRVLDKISIGQLVSLLSNNL--------NKFDEGLAL 197
G ++ + + ++ L+ DK G+L++ LS++ +GL
Sbjct: 237 QTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLR- 295
Query: 198 AHFVWIAPLQVALLMGLIWELLQASAFCGLGFLIVLALFQAGLGRMMMKYRDQRAGKISE 257
A Q ++ + +++ + A L + +++ GR + K +++
Sbjct: 296 ------AGAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQ 349
Query: 258 RLVITSEMIENIQSVKAYCWEEAMEKMIENLRQTELKLTRKAAYVRYFNSSAFFFSGFFV 317
+ E I N+++V+A+ E + + ++L RK A+ R A SG +
Sbjct: 350 ATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLI 409
Query: 318 VFLSVLPYALIKGIILRKI-----FTTISFCIVLRMAVTRQFPWAVQTWYDSLGAINKIQ 372
V + L+ G + F +F + + + F LGA ++
Sbjct: 410 VLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLSSF---YSELMKGLGAGGRLW 466
Query: 373 DFLQKQEYKTLEYNLTTTEVVMENVTAFWEEGFGELFEKAKQNNNNRKTSNGDDSLFFSN 432
+ L++ E L E V+ N +F G L K ++ F+
Sbjct: 467 ELLER------EPKLPFNEGVILNEKSFQ----GALEFK---------------NVHFAY 501
Query: 433 FSLLGTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHSG------ 486
+ P+ +D + I G + A+ G +G+GK+++L +++ +P+ G I G
Sbjct: 502 PARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQL 561
Query: 487 -------RISFCSQFSWIMPGTIKENIIFGV----SYDEYRYRSVIKACQLEEDISKFAE 535
+I SQ + +I ENI +G S + V + I F +
Sbjct: 562 NPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQ 621
Query: 536 KDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCKLM 595
N V+GE G+ LSGGQ+ RI++ARA+ K+ + LLD LD E + + + +LM
Sbjct: 622 GFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENE-YLVQEALDRLM 680
Query: 596 ANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSELQNLQPDFSSKLMGCDSF 650
+T +++ ++ +K A+ + +L +G YG EL + KLM SF
Sbjct: 681 DGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQSF 735
Score = 105 bits (263), Expect = 2e-22
Identities = 111/500 (22%), Positives = 212/500 (42%), Gaps = 39/500 (7%)
Query: 948 LHHKMLHSVLQAPMSTLNTLKAGGILNRFSKDIAILDDLLPLTIFDFIQLLLIVIGAIAV 1007
L + S+L+ ++ + + G ++NR S D A+L + + D ++ I++
Sbjct: 247 LRTSLFSSILRQEVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISM 306
Query: 1008 VAVLQPYIFVATVPVIVAFIMLRAYFLQTSQQLKQLESEGRSPIFTHLVTSLKGLWTLRA 1067
+ + P + + V+ ++ + + ++L ++ + + + + T+RA
Sbjct: 307 MFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRA 366
Query: 1068 FGRQ-----PYFETLFHKALNLHTANWFLYLSTLRWFQMRIEMIFVIFFIAVTFISILTT 1122
FG++ Y + H + L F + +I ++V + L
Sbjct: 367 FGKEMTEIEKYASKVDH-VMQLARKEAFARAGFFGATGLSGNLIV----LSVLYKGGLLM 421
Query: 1123 GEGEGRVGIILTLAMNIMSTLQWAVNSSIDVDSLMRSVSRVFKFIDMPT---EGKPTKST 1179
G VG + S L +A I + L S + K + E +
Sbjct: 422 GSAHMTVG-------ELSSFLMYAFWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPK 474
Query: 1180 KPYKNGQLSKVMIIENSHVKKDDIWPSGGQMTVKDLTAKYTEGGNA-ILENISFSISPGQ 1238
P+ G V++ E S G + K++ Y I ++ S SI G
Sbjct: 475 LPFNEG----VILNEKSFQ---------GALEFKNVHFAYPARPEVPIFQDFSLSIPSGS 521
Query: 1239 RVGLLGRTGSGKSTLLSAFLRLLN-TEGEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFS 1297
L+G +GSGKST+LS LRL + G I +DG + R G + Q+ +FS
Sbjct: 522 VTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFS 581
Query: 1298 GTFRKNL----DPYEQWSDQEIWKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQL 1353
+ +N+ D + +EI +VA+ + I FP + V+ + G +LS G KQ
Sbjct: 582 CSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQR 641
Query: 1354 MCLARSVLSKAKILLLDEPSAHLDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQF 1413
+ +AR++L KILLLDE ++ LD +++ L + TV++ HR+ +
Sbjct: 642 IAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMV 701
Query: 1414 LVIEENKVRQYDSIQKLLNE 1433
V+++ K+ +Y ++LL++
Sbjct: 702 AVLDQGKITEYGKHEELLSK 721
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 105 bits (262), Expect = 3e-22
Identities = 111/486 (22%), Positives = 210/486 (43%), Gaps = 71/486 (14%)
Query: 179 QLVSLLSNNLNKFDEGLALA---HFVWIAPLQVALLMGLI--WELLQASAFCGLGFLIVL 233
+L + L+++++K EG+ F +A ++G I W+L + +L
Sbjct: 172 ELNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVI----MAISPIL 227
Query: 234 ALFQAGLGRMMMKYRDQRAGKISERLVITSEMIENIQSVKAYCWE----EAMEKMIENLR 289
L A +++ + D+ ++ + E + I++V A+ + E +K +EN +
Sbjct: 228 GLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAK 287
Query: 290 QTELKLTRKAAYVRYFNSSAFFFSGFFVVFLS-VLPYALIKGIILRKIFT-----TISFC 343
+ +K + +++ F +++ S L + +++ K +T T+ F
Sbjct: 288 EIGIK--------KAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFS 339
Query: 344 IVLRMAVTRQFPWAVQTWYDSLGAINKIQDFLQKQEYKTLEYNLTTTEVVMENVTAFWEE 403
I++ Q + + ++ GA I D + + +F E
Sbjct: 340 ILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNP----------------KIDSFSER 383
Query: 404 GFGELFEKAKQNNNNRKTSNGDDSLFFSNFSLLGTPVLKDINFKIERGQLLAVAGSTGAG 463
G K N+ + FS S +LK +N K++ GQ +A+ GS+G G
Sbjct: 384 GHKPDSIKGNLEFND---------VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCG 434
Query: 464 KTSLLMVIMGELEPSEGKIKHSGR-------------ISFCSQFSWIMPGTIKENIIFG- 509
K++ + +I +P EG I G+ I SQ + TI ENI +G
Sbjct: 435 KSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGR 494
Query: 510 --VSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGGITLSGGQRARISLARAVYKDAD 567
V+ DE + +K E I K +K + ++GE G LSGGQ+ RI++ARA+ ++
Sbjct: 495 GNVTMDEIK--KAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPK 552
Query: 568 LYLLDSPFGYLDVLTEKEIFESCVCKLMANKTRILVTSKMEHLKKADKILILHEGSSYFY 627
+ LLD LD +E E+ ++ + K +T I++ ++ ++ AD I +G
Sbjct: 553 ILLLDEATSALDTESEAEV-QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQ 611
Query: 628 GTFSEL 633
G+ SEL
Sbjct: 612 GSHSEL 617
Score = 98.6 bits (244), Expect = 4e-20
Identities = 63/247 (25%), Positives = 120/247 (48%), Gaps = 12/247 (4%)
Query: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTE-- 1264
G +T ++ Y N +L+ +S + GQ + L+G +G GKST++ R +
Sbjct: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091
Query: 1265 ------GEIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNL---DPYEQWSDQEI 1315
G +DG + +Q R G++ Q+ +F + +N+ D S EI
Sbjct: 1092 TVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI 1151
Query: 1316 WKVADEVGLRSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAH 1375
A + IE P K + + D G LS G KQ + +AR+++ + +ILLLDE ++
Sbjct: 1152 VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSA 1211
Query: 1376 LDPVTYQIIRRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERS 1435
LD + ++++ L +A T I+ HR+ + +V + +V+++ + Q+LL ++
Sbjct: 1212 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1271
Query: 1436 LFRQAIS 1442
++ +S
Sbjct: 1272 IYFSMVS 1278
Score = 96.3 bits (238), Expect = 2e-19
Identities = 66/238 (27%), Positives = 114/238 (47%), Gaps = 3/238 (1%)
Query: 1208 GQMTVKDLTAKYTEGGNA-ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNT-EG 1265
G + D+ Y N IL+ ++ + GQ V L+G +G GKST + RL + EG
Sbjct: 392 GNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEG 451
Query: 1266 EIQIDGVSWDSITLQQWRKAFGVIPQKVFIFSGTFRKNLDPYE-QWSDQEIWKVADEVGL 1324
I IDG + + R+ GV+ Q+ +FS T +N+ + EI K E
Sbjct: 452 TINIDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANA 511
Query: 1325 RSVIEQFPGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHLDPVTYQII 1384
I + P K D ++ + G LS G KQ + +AR+++ KILLLDE ++ LD + +
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 1385 RRTLKQAFADCTVILCEHRIEAMLECQQFLVIEENKVRQYDSIQKLLNERSLFRQAIS 1442
+ L +A T I+ HR+ + E+ + + S +L+ + ++ + ++
Sbjct: 572 QAALDKAREGRTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVN 629
Score = 82.8 bits (203), Expect = 2e-15
Identities = 59/220 (26%), Positives = 105/220 (47%), Gaps = 28/220 (12%)
Query: 439 PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS------------- 485
PVL+ ++ ++++GQ LA+ GS+G GK++++ ++ +P G +
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKK 1109
Query: 486 -------GRISFCSQFSWIMPGTIKENIIFG-----VSYDEYRYRSVIKACQLEEDISKF 533
++ SQ + +I ENI +G VS DE S KA + I
Sbjct: 1110 LNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIV--SAAKAANIHPFIETL 1167
Query: 534 AEKDNIVLGEGGITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFESCVCK 593
K +G+ G LSGGQ+ RI++ARA+ + + LLD LD +EK + + + K
Sbjct: 1168 PHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK-VVQEALDK 1226
Query: 594 LMANKTRILVTSKMEHLKKADKILILHEGSSYFYGTFSEL 633
+T I++ ++ ++ AD I++ G +GT +L
Sbjct: 1227 AREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL 1266
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,836,463
Number of Sequences: 37866
Number of extensions: 2081522
Number of successful extensions: 5920
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 76
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 5293
Number of HSP's gapped (non-prelim): 367
length of query: 1480
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1365
effective length of database: 13,892,928
effective search space: 18963846720
effective search space used: 18963846720
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.