BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|8922944 lin-7 homolog C [Homo sapiens] (197 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|8922944 lin-7 homolog C [Homo sapiens] 385 e-107 gi|11545920 lin-7 homolog B [Homo sapiens] 337 4e-93 gi|4759306 lin-7 homolog A [Homo sapiens] 318 2e-87 gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 86 2e-17 gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 86 3e-17 gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 86 3e-17 gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 82 2e-16 gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 82 3e-16 gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 78 6e-15 gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 78 6e-15 gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 76 2e-14 gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 76 2e-14 gi|9966877 golgi associated PDZ and coiled-coil motif containing... 74 6e-14 gi|62868213 golgi associated PDZ and coiled-coil motif containin... 74 6e-14 gi|148746189 multiple PDZ domain protein [Homo sapiens] 71 5e-13 gi|66346708 membrane associated guanylate kinase, WW and PDZ dom... 71 5e-13 gi|74272284 membrane associated guanylate kinase, WW and PDZ dom... 71 5e-13 gi|74272282 membrane associated guanylate kinase, WW and PDZ dom... 71 5e-13 gi|31742501 sorting nexin family member 27 [Homo sapiens] 69 3e-12 gi|5453992 protein tyrosine phosphatase, non-receptor type 13 is... 69 3e-12 gi|5803177 basic beta 2 syntrophin [Homo sapiens] 68 6e-12 gi|18375650 protein tyrosine phosphatase, non-receptor type 13 i... 67 8e-12 gi|18375648 protein tyrosine phosphatase, non-receptor type 13 i... 67 8e-12 gi|18375646 protein tyrosine phosphatase, non-receptor type 13 i... 67 8e-12 gi|7706025 PDZ domain containing 11 [Homo sapiens] 66 2e-11 gi|112382257 InaD-like [Homo sapiens] 66 2e-11 gi|27436957 membrane associated guanylate kinase, WW and PDZ dom... 65 3e-11 gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] 65 3e-11 gi|45827729 scribble isoform b [Homo sapiens] 65 4e-11 gi|45827731 scribble isoform a [Homo sapiens] 65 4e-11 >gi|8922944 lin-7 homolog C [Homo sapiens] Length = 197 Score = 385 bits (989), Expect = e-107 Identities = 197/197 (100%), Positives = 197/197 (100%) Query: 1 MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYET 60 MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYET Sbjct: 1 MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYET 60 Query: 61 VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYIS 120 VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYIS Sbjct: 61 VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYIS 120 Query: 121 RIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEE 180 RIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEE Sbjct: 121 RIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEE 180 Query: 181 MESRFEKMRSAKRRQQT 197 MESRFEKMRSAKRRQQT Sbjct: 181 MESRFEKMRSAKRRQQT 197 >gi|11545920 lin-7 homolog B [Homo sapiens] Length = 207 Score = 337 bits (864), Expect = 4e-93 Identities = 166/196 (84%), Positives = 186/196 (94%) Query: 1 MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYET 60 MAAL EP+ LERD+ RA+ELLE+LQRSGE+PPQKLQALQRVLQS FC+A+REVYE +Y+T Sbjct: 1 MAALVEPLGLERDVSRAVELLERLQRSGELPPQKLQALQRVLQSRFCSAIREVYEQLYDT 60 Query: 61 VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYIS 120 +DI+ S E+RA+ATAKATVAAF ASEGH+HPRVVELPKT+EGLGFNIMGGKEQNSPIYIS Sbjct: 61 LDITGSAEIRAHATAKATVAAFTASEGHAHPRVVELPKTDEGLGFNIMGGKEQNSPIYIS 120 Query: 121 RIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEE 180 R+IPGG+ADRHGGLKRGDQLLSVNGVSVEGE HEKAVELLKAAQG VKLVVRYTP+VLEE Sbjct: 121 RVIPGGVADRHGGLKRGDQLLSVNGVSVEGEQHEKAVELLKAAQGSVKLVVRYTPRVLEE 180 Query: 181 MESRFEKMRSAKRRQQ 196 ME+RFEKMRSA+RRQQ Sbjct: 181 MEARFEKMRSARRRQQ 196 >gi|4759306 lin-7 homolog A [Homo sapiens] Length = 233 Score = 318 bits (814), Expect = 2e-87 Identities = 154/191 (80%), Positives = 178/191 (93%) Query: 6 EPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISS 65 +P+ L+RD+ RAIELLEKLQ SGEVP KLQ+L++VLQSEFC A+REVY++++ET+ ++ Sbjct: 21 QPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNG 80 Query: 66 SPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPG 125 PE RA ATAKATVAAFAASEGHSHPRVVELPKT+EGLGFN+MGGKEQNSPIYISRIIPG Sbjct: 81 CPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPG 140 Query: 126 GIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRF 185 G+A+RHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAA+ VKLVVRYTPKVLEEME+RF Sbjct: 141 GVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARF 200 Query: 186 EKMRSAKRRQQ 196 EK+R+A+RRQQ Sbjct: 201 EKLRTARRRQQ 211 >gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] Length = 749 Score = 85.9 bits (211), Expect = 2e-17 Identities = 49/128 (38%), Positives = 70/128 (54%), Gaps = 1/128 (0%) Query: 62 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISR 121 D +S + AT + ++ A PR V L K GLGFNI+GG E I++S Sbjct: 287 DDYTSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGEGIFVSF 345 Query: 122 IIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEM 181 I+ GG AD G L+RGDQ+LSVNG+ + G HE+A LK A V ++ +Y P+ Sbjct: 346 ILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARF 405 Query: 182 ESRFEKMR 189 E++ +R Sbjct: 406 EAKIHDLR 413 Score = 62.0 bits (149), Expect = 3e-10 Identities = 38/91 (41%), Positives = 50/91 (54%), Gaps = 5/91 (5%) Query: 94 VELPKTEEGLGFNIMGGKEQ-----NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSV 148 + L + GLGF+I GG + + I+I++IIPGG A G L+ D +L VN V V Sbjct: 48 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 107 Query: 149 EGEHHEKAVELLKAAQGKVKLVVRYTPKVLE 179 H KAVE LK A V+L VR +LE Sbjct: 108 SEVSHSKAVEALKEAGSIVRLYVRRRRPILE 138 Score = 60.1 bits (144), Expect = 1e-09 Identities = 45/117 (38%), Positives = 62/117 (52%), Gaps = 7/117 (5%) Query: 62 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELP--KTEEGLGFNIMGGK-EQNSP-- 116 ++S S V A A + V + VVE+ K +GLGF+I GG Q+ P Sbjct: 109 EVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGD 168 Query: 117 --IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 IY+++II GG A + G L+ GD+LL VN S+E HE+AV +LK V L V Sbjct: 169 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 225 >gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] Length = 975 Score = 85.5 bits (210), Expect = 3e-17 Identities = 48/125 (38%), Positives = 69/125 (55%), Gaps = 1/125 (0%) Query: 65 SSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIP 124 +S + AT + ++ A PR V L K GLGFNI+GG E I++S I+ Sbjct: 498 TSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGEGIFVSFILA 556 Query: 125 GGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESR 184 GG AD G L+RGDQ+LSVNG+ + G HE+A LK A V ++ +Y P+ E++ Sbjct: 557 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAK 616 Query: 185 FEKMR 189 +R Sbjct: 617 IHDLR 621 Score = 62.0 bits (149), Expect = 3e-10 Identities = 38/91 (41%), Positives = 50/91 (54%), Gaps = 5/91 (5%) Query: 94 VELPKTEEGLGFNIMGGKEQ-----NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSV 148 + L + GLGF+I GG + + I+I++IIPGG A G L+ D +L VN V V Sbjct: 204 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 263 Query: 149 EGEHHEKAVELLKAAQGKVKLVVRYTPKVLE 179 H KAVE LK A V+L VR +LE Sbjct: 264 SEVSHSKAVEALKEAGSIVRLYVRRRRPILE 294 Score = 60.1 bits (144), Expect = 1e-09 Identities = 45/117 (38%), Positives = 62/117 (52%), Gaps = 7/117 (5%) Query: 62 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELP--KTEEGLGFNIMGGK-EQNSP-- 116 ++S S V A A + V + VVE+ K +GLGF+I GG Q+ P Sbjct: 265 EVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGD 324 Query: 117 --IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 IY+++II GG A + G L+ GD+LL VN S+E HE+AV +LK V L V Sbjct: 325 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 381 >gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] Length = 870 Score = 85.5 bits (210), Expect = 3e-17 Identities = 48/125 (38%), Positives = 69/125 (55%), Gaps = 1/125 (0%) Query: 65 SSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIP 124 +S + AT + ++ A PR V L K GLGFNI+GG E I++S I+ Sbjct: 393 TSHSQHSTATRQPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGG-EDGEGIFVSFILA 451 Query: 125 GGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESR 184 GG AD G L+RGDQ+LSVNG+ + G HE+A LK A V ++ +Y P+ E++ Sbjct: 452 GGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKGAGQTVTIIAQYQPEDYARFEAK 511 Query: 185 FEKMR 189 +R Sbjct: 512 IHDLR 516 Score = 62.0 bits (149), Expect = 3e-10 Identities = 38/91 (41%), Positives = 50/91 (54%), Gaps = 5/91 (5%) Query: 94 VELPKTEEGLGFNIMGGKEQ-----NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSV 148 + L + GLGF+I GG + + I+I++IIPGG A G L+ D +L VN V V Sbjct: 99 ITLERGNSGLGFSIAGGTDNPHIGDDPGIFITKIIPGGAAAEDGRLRVNDCILRVNEVDV 158 Query: 149 EGEHHEKAVELLKAAQGKVKLVVRYTPKVLE 179 H KAVE LK A V+L VR +LE Sbjct: 159 SEVSHSKAVEALKEAGSIVRLYVRRRRPILE 189 Score = 60.1 bits (144), Expect = 1e-09 Identities = 45/117 (38%), Positives = 62/117 (52%), Gaps = 7/117 (5%) Query: 62 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELP--KTEEGLGFNIMGGK-EQNSP-- 116 ++S S V A A + V + VVE+ K +GLGF+I GG Q+ P Sbjct: 160 EVSHSKAVEALKEAGSIVRLYVRRRRPILETVVEIKLFKGPKGLGFSIAGGVGNQHIPGD 219 Query: 117 --IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 IY+++II GG A + G L+ GD+LL VN S+E HE+AV +LK V L V Sbjct: 220 NSIYVTKIIDGGAAQKDGRLQVGDRLLMVNNYSLEEVTHEEAVAILKNTSEVVYLKV 276 >gi|119943106 synapse-associated protein 102 isoform a [Homo sapiens] Length = 817 Score = 82.4 bits (202), Expect = 2e-16 Identities = 49/133 (36%), Positives = 69/133 (51%), Gaps = 1/133 (0%) Query: 57 VYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSP 116 V V + P+V + A + PR + L K GLGFNI+GG E Sbjct: 350 VESKVSYPAPPQVPPTRYSPIPRHMLAEEDFTREPRKIILHKGSTGLGFNIVGG-EDGEG 408 Query: 117 IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPK 176 I++S I+ GG AD G L+RGD++LSVNGV++ HE+A LK A V +V +Y P+ Sbjct: 409 IFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKRAGQSVTIVAQYRPE 468 Query: 177 VLEEMESRFEKMR 189 ES+ +R Sbjct: 469 EYSRFESKIHDLR 481 Score = 58.5 bits (140), Expect = 3e-09 Identities = 37/83 (44%), Positives = 50/83 (60%), Gaps = 5/83 (6%) Query: 94 VELPKTEEGLGFNIMGG-KEQNSP----IYISRIIPGGIADRHGGLKRGDQLLSVNGVSV 148 V L K +GLGF+I GG Q+ P IYI++II GG A + G L+ GD+LL+VN ++ Sbjct: 227 VNLLKGPKGLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGDRLLAVNNTNL 286 Query: 149 EGEHHEKAVELLKAAQGKVKLVV 171 + HE+AV LK V L V Sbjct: 287 QDVRHEEAVASLKNTSDMVYLKV 309 Score = 56.6 bits (135), Expect = 1e-08 Identities = 38/93 (40%), Positives = 50/93 (53%), Gaps = 5/93 (5%) Query: 85 SEGHSHPRVVELPKTEEGLGFNIMGGKEQ-----NSPIYISRIIPGGIADRHGGLKRGDQ 139 S+G + L + GLGF+I GG + + I+I++IIPGG A G L D Sbjct: 123 SDGMFKYEEIVLERGNSGLGFSIAGGIDNPHVPDDPGIFITKIIPGGAAAMDGRLGVNDC 182 Query: 140 LLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVR 172 +L VN V V H +AVE LK A V+LVVR Sbjct: 183 VLRVNEVDVSEVVHSRAVEALKEAGPVVRLVVR 215 >gi|119943108 synapse-associated protein 102 isoform b [Homo sapiens] Length = 512 Score = 82.0 bits (201), Expect = 3e-16 Identities = 44/99 (44%), Positives = 60/99 (60%), Gaps = 1/99 (1%) Query: 91 PRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 PR + L K GLGFNI+GG E I++S I+ GG AD G L+RGD++LSVNGV++ Sbjct: 47 PRKIILHKGSTGLGFNIVGG-EDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRN 105 Query: 151 EHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMR 189 HE+A LK A V +V +Y P+ ES+ +R Sbjct: 106 ATHEQAAAALKRAGQSVTIVAQYRPEEYSRFESKIHDLR 144 >gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapiens] Length = 767 Score = 77.8 bits (190), Expect = 6e-15 Identities = 41/99 (41%), Positives = 59/99 (59%), Gaps = 1/99 (1%) Query: 91 PRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 PR + + + GLGFNI+GG E I+IS I+ GG AD G L++GDQ+LSVNGV + Sbjct: 354 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 412 Query: 151 EHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMR 189 HE+A LK A V ++ +Y P+ E++ +R Sbjct: 413 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLR 451 Score = 61.2 bits (147), Expect = 5e-10 Identities = 41/109 (37%), Positives = 57/109 (52%), Gaps = 6/109 (5%) Query: 85 SEGHSHPRVVELPKTEEGLGFNIMGGKEQ-----NSPIYISRIIPGGIADRHGGLKRGDQ 139 +EG + L + GLGF+I GG + + I+I++IIPGG A + G L+ D Sbjct: 100 TEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDS 159 Query: 140 LLSVNGVSVEGEHHEKAVELLKAAQGKVKL-VVRYTPKVLEEMESRFEK 187 +L VN V V H AVE LK A V+L V+R P + ME + K Sbjct: 160 ILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIK 208 Score = 58.2 bits (139), Expect = 5e-09 Identities = 42/117 (35%), Positives = 62/117 (52%), Gaps = 7/117 (5%) Query: 62 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELP--KTEEGLGFNIMGGK-EQNSP-- 116 +++ S V A A + V + +V+E+ K +GLGF+I GG Q+ P Sbjct: 170 EVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGD 229 Query: 117 --IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 IY+++II GG A + G L+ GD++L+VN V +E HE AV LK V L V Sbjct: 230 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 286 >gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sapiens] Length = 721 Score = 77.8 bits (190), Expect = 6e-15 Identities = 41/99 (41%), Positives = 59/99 (59%), Gaps = 1/99 (1%) Query: 91 PRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 PR + + + GLGFNI+GG E I+IS I+ GG AD G L++GDQ+LSVNGV + Sbjct: 308 PRRIVIHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRN 366 Query: 151 EHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMR 189 HE+A LK A V ++ +Y P+ E++ +R Sbjct: 367 ASHEQAAIALKNAGQTVTIIAQYKPEEYSRFEAKIHDLR 405 Score = 64.3 bits (155), Expect = 6e-11 Identities = 45/130 (34%), Positives = 63/130 (48%), Gaps = 6/130 (4%) Query: 64 SSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQ-----NSPIY 118 ++SP V N +EG + L + GLGF+I GG + + I+ Sbjct: 33 ANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIF 92 Query: 119 ISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKL-VVRYTPKV 177 I++IIPGG A + G L+ D +L VN V V H AVE LK A V+L V+R P Sbjct: 93 ITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVMRRKPPA 152 Query: 178 LEEMESRFEK 187 + ME + K Sbjct: 153 EKVMEIKLIK 162 Score = 58.2 bits (139), Expect = 5e-09 Identities = 42/117 (35%), Positives = 62/117 (52%), Gaps = 7/117 (5%) Query: 62 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELP--KTEEGLGFNIMGGK-EQNSP-- 116 +++ S V A A + V + +V+E+ K +GLGF+I GG Q+ P Sbjct: 124 EVTHSAAVEALKEAGSIVRLYVMRRKPPAEKVMEIKLIKGPKGLGFSIAGGVGNQHIPGD 183 Query: 117 --IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 IY+++II GG A + G L+ GD++L+VN V +E HE AV LK V L V Sbjct: 184 NSIYVTKIIEGGAAHKDGRLQIGDKILAVNSVGLEDVMHEDAVAALKNTYDVVYLKV 240 >gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] Length = 904 Score = 75.9 bits (185), Expect = 2e-14 Identities = 41/99 (41%), Positives = 58/99 (58%), Gaps = 1/99 (1%) Query: 91 PRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 PR V L + GLGFNI+GG E I+IS I+ GG AD G L++GD+++SVN V + Sbjct: 464 PRKVVLHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522 Query: 151 EHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMR 189 HE+A LK A V +V +Y P+ E++ +R Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLR 561 Score = 63.5 bits (153), Expect = 1e-10 Identities = 42/130 (32%), Positives = 64/130 (49%), Gaps = 5/130 (3%) Query: 57 VYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQ--- 113 + T+ ++ P V N + T ++ + L + GLGF+I GG + Sbjct: 188 ILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHI 247 Query: 114 --NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 +S I+I++II GG A + G L+ D +L VN V V H KAVE LK A V+L V Sbjct: 248 GDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV 307 Query: 172 RYTPKVLEEM 181 + V E++ Sbjct: 308 KRRKPVSEKI 317 Score = 60.1 bits (144), Expect = 1e-09 Identities = 43/117 (36%), Positives = 63/117 (53%), Gaps = 7/117 (5%) Query: 62 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELP--KTEEGLGFNIMGGK-EQNSP-- 116 D++ S V A A + V + +++E+ K +GLGF+I GG Q+ P Sbjct: 286 DVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGD 345 Query: 117 --IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 IY+++II GG A + G L+ GD+LL+VN V +E HE+AV LK V L V Sbjct: 346 NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402 >gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] Length = 926 Score = 75.9 bits (185), Expect = 2e-14 Identities = 41/99 (41%), Positives = 58/99 (58%), Gaps = 1/99 (1%) Query: 91 PRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 PR V L + GLGFNI+GG E I+IS I+ GG AD G L++GD+++SVN V + Sbjct: 464 PRKVVLHRGSTGLGFNIVGG-EDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRA 522 Query: 151 EHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMR 189 HE+A LK A V +V +Y P+ E++ +R Sbjct: 523 ASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLR 561 Score = 63.5 bits (153), Expect = 1e-10 Identities = 42/130 (32%), Positives = 64/130 (49%), Gaps = 5/130 (3%) Query: 57 VYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQ--- 113 + T+ ++ P V N + T ++ + L + GLGF+I GG + Sbjct: 188 ILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHI 247 Query: 114 --NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 +S I+I++II GG A + G L+ D +L VN V V H KAVE LK A V+L V Sbjct: 248 GDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYV 307 Query: 172 RYTPKVLEEM 181 + V E++ Sbjct: 308 KRRKPVSEKI 317 Score = 60.1 bits (144), Expect = 1e-09 Identities = 43/117 (36%), Positives = 63/117 (53%), Gaps = 7/117 (5%) Query: 62 DISSSPEVRANATAKATVAAFAASEGHSHPRVVELP--KTEEGLGFNIMGGK-EQNSP-- 116 D++ S V A A + V + +++E+ K +GLGF+I GG Q+ P Sbjct: 286 DVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGD 345 Query: 117 --IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 IY+++II GG A + G L+ GD+LL+VN V +E HE+AV LK V L V Sbjct: 346 NSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKV 402 >gi|9966877 golgi associated PDZ and coiled-coil motif containing isoform a [Homo sapiens] Length = 462 Score = 74.3 bits (181), Expect = 6e-14 Identities = 39/95 (41%), Positives = 57/95 (60%) Query: 92 RVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 +V+ L + EGLG +I GGKE PI IS I PG ADR GGL GD +L+VNGV++ Sbjct: 288 KVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 347 Query: 152 HHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFE 186 H++AV +L +G+++ V Y ++ + E Sbjct: 348 KHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVE 382 >gi|62868213 golgi associated PDZ and coiled-coil motif containing isoform b [Homo sapiens] Length = 454 Score = 74.3 bits (181), Expect = 6e-14 Identities = 39/95 (41%), Positives = 57/95 (60%) Query: 92 RVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 +V+ L + EGLG +I GGKE PI IS I PG ADR GGL GD +L+VNGV++ Sbjct: 280 KVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDT 339 Query: 152 HHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFE 186 H++AV +L +G+++ V Y ++ + E Sbjct: 340 KHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVE 374 >gi|148746189 multiple PDZ domain protein [Homo sapiens] Length = 2041 Score = 71.2 bits (173), Expect = 5e-13 Identities = 39/101 (38%), Positives = 58/101 (57%), Gaps = 3/101 (2%) Query: 74 TAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGG---KEQNSPIYISRIIPGGIADR 130 T + + F G + + L + +GLGF+I+GG + PIY+ + G A Sbjct: 1939 TGLTSSSIFQDDLGPPQCKSITLERGPDGLGFSIVGGYGSPHGDLPIYVKTVFAKGAASE 1998 Query: 131 HGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 G LKRGDQ+++VNG S+EG HE+AV +LK +G V L+V Sbjct: 1999 DGRLKRGDQIIAVNGQSLEGVTHEEAVAILKRTKGTVTLMV 2039 Score = 69.7 bits (169), Expect = 2e-12 Identities = 35/106 (33%), Positives = 58/106 (54%), Gaps = 2/106 (1%) Query: 66 SPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPG 125 SP V + +A +T++A + H +EL GLGF I+GGK + + I+PG Sbjct: 230 SPIVSRSPSAASTISAHSNPVHWQHMETIELVNDGSGLGFGIIGGKATG--VIVKTILPG 287 Query: 126 GIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 G+AD+HG L GD +L + + G E+ ++L+ +VKL++ Sbjct: 288 GVADQHGRLCSGDHILKIGDTDLAGMSSEQVAQVLRQCGNRVKLMI 333 Score = 58.9 bits (141), Expect = 3e-09 Identities = 35/83 (42%), Positives = 52/83 (62%), Gaps = 5/83 (6%) Query: 94 VELPKTEEGLGFNIMGGKEQNSP----IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVE 149 +EL K +GLGF+I+ ++ P I I ++PGGIA++ G L GD+L+ VN V++E Sbjct: 701 IELEKGSKGLGFSILDYQDPIDPASTVIIIRSLVPGGIAEKDGRLLPGDRLMFVNDVNLE 760 Query: 150 GEHHEKAVELLKAA-QGKVKLVV 171 E+AVE LK A G V++ V Sbjct: 761 NSSLEEAVEALKGAPSGTVRIGV 783 Score = 57.4 bits (137), Expect = 8e-09 Identities = 28/79 (35%), Positives = 47/79 (59%), Gaps = 1/79 (1%) Query: 93 VVELPKTEEGLGFNIMGGKEQNS-PIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 ++EL K GLG ++ G K+++ ++I I P G A + G L+ D+LL +NG + G Sbjct: 1350 MIELEKGHSGLGLSLAGNKDRSRMSVFIVGIDPNGAAGKDGRLQIADELLEINGQILYGR 1409 Query: 152 HHEKAVELLKAAQGKVKLV 170 H+ A ++K A KVK++ Sbjct: 1410 SHQNASSIIKCAPSKVKII 1428 Score = 57.0 bits (136), Expect = 1e-08 Identities = 29/70 (41%), Positives = 43/70 (61%), Gaps = 1/70 (1%) Query: 98 KTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAV 157 K +GLG +I+G K ++ +++S I+ GGIAD G L +GDQ+L VNG V E Sbjct: 1731 KPGKGLGLSIVG-KRNDTGVFVSDIVKGGIADADGRLMQGDQILMVNGEDVRNATQEAVA 1789 Query: 158 ELLKAAQGKV 167 LLK ++G + Sbjct: 1790 ALLKVSEGSL 1799 Score = 53.9 bits (128), Expect = 9e-08 Identities = 36/115 (31%), Positives = 59/115 (51%), Gaps = 8/115 (6%) Query: 64 SSSPEVRANATAKATVAAFAASEGHSHPRV------VELPKTEEGLGFNIMGGKEQN-SP 116 S PE N + +T A FA S+ + P + +E+ K GLG +I+GG + Sbjct: 1595 SPEPESIRNTSRSSTPAIFA-SDPATCPIIPGCETTIEISKGRTGLGLSIVGGSDTLLGA 1653 Query: 117 IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 I I + G A + G L GDQ+L VNG+ + H++A+ +L+ +V+L + Sbjct: 1654 IIIHEVYEEGAACKDGRLWAGDQILEVNGIDLRKATHDEAINVLRQTPQRVRLTL 1708 Score = 53.1 bits (126), Expect = 1e-07 Identities = 31/87 (35%), Positives = 53/87 (60%), Gaps = 5/87 (5%) Query: 90 HPRVVELPKTEEG-LGFNIMGGKEQNSP---IYISRIIPGGIADRHGGLKRGDQLLSVNG 145 H V EL K G LGF+++G + +N I++ I G +A R G LK DQ+L++NG Sbjct: 134 HVEVFELLKPPSGGLGFSVVGLRSENRGELGIFVQEIQEGSVAHRDGRLKETDQILAING 193 Query: 146 VSVEGE-HHEKAVELLKAAQGKVKLVV 171 +++ H++A+ +L+ A+ V+LV+ Sbjct: 194 QALDQTITHQQAISILQKAKDTVQLVI 220 Score = 52.4 bits (124), Expect = 2e-07 Identities = 31/84 (36%), Positives = 50/84 (59%), Gaps = 4/84 (4%) Query: 92 RVVELPK-TEEGLGFNIMGGKEQ---NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVS 147 R VE+ K + LG +I GG + PI+I+ + P G+A + L+ GD+++++ G S Sbjct: 1832 RTVEMKKGPTDSLGISIAGGVGSPLGDVPIFIAMMHPTGVAAQTQKLRVGDRIVTICGTS 1891 Query: 148 VEGEHHEKAVELLKAAQGKVKLVV 171 EG H +AV LLK A G +++ V Sbjct: 1892 TEGMTHTQAVNLLKNASGSIEMQV 1915 Score = 50.1 bits (118), Expect = 1e-06 Identities = 38/110 (34%), Positives = 56/110 (50%), Gaps = 3/110 (2%) Query: 64 SSSPEVRANATAKATVAAFAASEGHSHPRV--VELPKTEEGLGFNIMGGKEQNSPIYISR 121 S+S ++ T + AA + S V +ELPK + GLG I ++ S + I Sbjct: 1452 SNSENLQNKETEPTVTTSDAAVDLSSFKNVQHLELPKDQGGLGIAI-SEEDTLSGVIIKS 1510 Query: 122 IIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 + G+A G LK GDQ+L+V+ V G EK + LLK A+ VKL + Sbjct: 1511 LTEHGVAATDGRLKVGDQILAVDDEIVVGYPIEKFISLLKTAKMTVKLTI 1560 Score = 49.7 bits (117), Expect = 2e-06 Identities = 39/136 (28%), Positives = 68/136 (50%), Gaps = 9/136 (6%) Query: 61 VDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMG----GKEQNSP 116 + +SSSP +T + V A S VEL K +GLG I G K + S Sbjct: 349 ITLSSSP----TSTPELRVDASTQKGEESETFDVELTKNVQGLGITIAGYIGDKKLEPSG 404 Query: 117 IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLK-AAQGKVKLVVRYTP 175 I++ I + G ++ GDQ+++V+G +++G +++AVE+L+ Q + ++R Sbjct: 405 IFVKSITKSSAVEHDGRIQIGDQIIAVDGTNLQGFTNQQAVEVLRHTGQTVLLTLMRRGM 464 Query: 176 KVLEEMESRFEKMRSA 191 K E+ SR + + A Sbjct: 465 KQEAELMSREDVTKDA 480 Score = 49.7 bits (117), Expect = 2e-06 Identities = 36/125 (28%), Positives = 60/125 (48%), Gaps = 11/125 (8%) Query: 58 YETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVEL-PKTEEGLGFNIMGGKEQNSP 116 Y DI PE R + + A + PR VEL + + LG +I+GG+ S Sbjct: 1117 YTGRDIPELPE-REEGEGEESELQNTAYSNWNQPRRVELWREPSKSLGISIVGGRGMGSR 1175 Query: 117 ---------IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKV 167 I+I ++ A ++G LK GD+++ V+G+ + HE+AVE ++ A V Sbjct: 1176 LSNGEVMRGIFIKHVLEDSPAGKNGTLKPGDRIVEVDGMDLRDASHEQAVEAIRKAGNPV 1235 Query: 168 KLVVR 172 +V+ Sbjct: 1236 VFMVQ 1240 Score = 42.7 bits (99), Expect = 2e-04 Identities = 20/53 (37%), Positives = 32/53 (60%) Query: 118 YISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLV 170 +I ++P G G L GD+LL VNG+++ GE+H+ V +LK +V +V Sbjct: 577 FIRSVLPEGPVGHSGKLFSGDELLEVNGITLLGENHQDVVNILKELPIEVTMV 629 Score = 32.0 bits (71), Expect = 0.35 Identities = 21/73 (28%), Positives = 33/73 (45%), Gaps = 1/73 (1%) Query: 89 SHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSV 148 S R + + K LG + K+ I + II GG R G + GD +LS+N S Sbjct: 1004 SFERTINIAKGNSSLGMTVSANKDGLGMI-VRSIIHGGAISRDGRIAIGDCILSINEEST 1062 Query: 149 EGEHHEKAVELLK 161 + +A +L+ Sbjct: 1063 ISVTNAQARAMLR 1075 >gi|66346708 membrane associated guanylate kinase, WW and PDZ domain containing 1 isoform b [Homo sapiens] Length = 1256 Score = 71.2 bits (173), Expect = 5e-13 Identities = 36/77 (46%), Positives = 48/77 (62%), Gaps = 2/77 (2%) Query: 98 KTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAV 157 + E G GF I+GG E PIYI I+P G AD G L+ GD+L+ V+G V G+ H+ V Sbjct: 846 RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV 905 Query: 158 ELLK--AAQGKVKLVVR 172 +L++ A QG V L VR Sbjct: 906 QLMQQAAKQGHVNLTVR 922 Score = 65.1 bits (157), Expect = 4e-11 Identities = 28/79 (35%), Positives = 51/79 (64%) Query: 94 VELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHH 153 VEL + +G GF++ GG+E N +Y+ R+ G A+R G ++ GD++L +NG + + H Sbjct: 1153 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1212 Query: 154 EKAVELLKAAQGKVKLVVR 172 +A+EL+K +V+L ++ Sbjct: 1213 SRAIELIKNGGRRVRLFLK 1231 Score = 48.9 bits (115), Expect = 3e-06 Identities = 33/85 (38%), Positives = 42/85 (49%), Gaps = 2/85 (2%) Query: 85 SEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVN 144 +EG V + + E G F G P I RII G ADR G LK GD++L+VN Sbjct: 1006 NEGFGFVIVSSVSRPEAGTTF--AGNACVAMPHKIGRIIEGSPADRCGKLKVGDRILAVN 1063 Query: 145 GVSVEGEHHEKAVELLKAAQGKVKL 169 G S+ + H V L+K A V L Sbjct: 1064 GCSITNKSHSDIVNLIKEAGNTVTL 1088 Score = 44.3 bits (103), Expect = 7e-05 Identities = 21/68 (30%), Positives = 38/68 (55%) Query: 95 ELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHE 154 +L K+ G GF ++GG E + + I ++ G A G ++ GD ++SVN V G H Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533 Query: 155 KAVELLKA 162 + V++ ++ Sbjct: 534 QVVKIFQS 541 Score = 28.5 bits (62), Expect = 3.9 Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 10/70 (14%) Query: 94 VELPKTEEGLGFNIM---GGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 V + K G GF I GG Q + +I+ + R GLK GD ++ VN +V+ Sbjct: 644 VHIVKGPMGFGFTIADSPGGGGQR----VKQIVD---SPRCRGLKEGDLIVEVNKKNVQA 696 Query: 151 EHHEKAVELL 160 H + V++L Sbjct: 697 LTHNQVVDML 706 >gi|74272284 membrane associated guanylate kinase, WW and PDZ domain containing 1 isoform c [Homo sapiens] Length = 1462 Score = 71.2 bits (173), Expect = 5e-13 Identities = 36/77 (46%), Positives = 48/77 (62%), Gaps = 2/77 (2%) Query: 98 KTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAV 157 + E G GF I+GG E PIYI I+P G AD G L+ GD+L+ V+G V G+ H+ V Sbjct: 818 RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV 877 Query: 158 ELLK--AAQGKVKLVVR 172 +L++ A QG V L VR Sbjct: 878 QLMQQAAKQGHVNLTVR 894 Score = 65.1 bits (157), Expect = 4e-11 Identities = 28/79 (35%), Positives = 51/79 (64%) Query: 94 VELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHH 153 VEL + +G GF++ GG+E N +Y+ R+ G A+R G ++ GD++L +NG + + H Sbjct: 1124 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1183 Query: 154 EKAVELLKAAQGKVKLVVR 172 +A+EL+K +V+L ++ Sbjct: 1184 SRAIELIKNGGRRVRLFLK 1202 Score = 48.9 bits (115), Expect = 3e-06 Identities = 35/92 (38%), Positives = 45/92 (48%), Gaps = 13/92 (14%) Query: 91 PRVVELPKTE-EGLGFNIMGGKEQNS------------PIYISRIIPGGIADRHGGLKRG 137 P VE+ + E EG GF I+ + P I RII G ADR G LK G Sbjct: 968 PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVG 1027 Query: 138 DQLLSVNGVSVEGEHHEKAVELLKAAQGKVKL 169 D++L+VNG S+ + H V L+K A V L Sbjct: 1028 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1059 Score = 44.3 bits (103), Expect = 7e-05 Identities = 21/68 (30%), Positives = 38/68 (55%) Query: 95 ELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHE 154 +L K+ G GF ++GG E + + I ++ G A G ++ GD ++SVN V G H Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533 Query: 155 KAVELLKA 162 + V++ ++ Sbjct: 534 QVVKIFQS 541 Score = 28.5 bits (62), Expect = 3.9 Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 10/70 (14%) Query: 94 VELPKTEEGLGFNIM---GGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 V + K G GF I GG Q + +I+ + R GLK GD ++ VN +V+ Sbjct: 644 VHIVKGPMGFGFTIADSPGGGGQR----VKQIVD---SPRCRGLKEGDLIVEVNKKNVQA 696 Query: 151 EHHEKAVELL 160 H + V++L Sbjct: 697 LTHNQVVDML 706 >gi|74272282 membrane associated guanylate kinase, WW and PDZ domain containing 1 isoform a [Homo sapiens] Length = 1287 Score = 71.2 bits (173), Expect = 5e-13 Identities = 36/77 (46%), Positives = 48/77 (62%), Gaps = 2/77 (2%) Query: 98 KTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAV 157 + E G GF I+GG E PIYI I+P G AD G L+ GD+L+ V+G V G+ H+ V Sbjct: 846 RKETGFGFRILGGNEPGEPIYIGHIVPLGAADTDGRLRSGDELICVDGTPVIGKSHQLVV 905 Query: 158 ELLK--AAQGKVKLVVR 172 +L++ A QG V L VR Sbjct: 906 QLMQQAAKQGHVNLTVR 922 Score = 65.1 bits (157), Expect = 4e-11 Identities = 28/79 (35%), Positives = 51/79 (64%) Query: 94 VELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHH 153 VEL + +G GF++ GG+E N +Y+ R+ G A+R G ++ GD++L +NG + + H Sbjct: 1152 VELERGAKGFGFSLRGGREYNMDLYVLRLAEDGPAERCGKMRIGDEILEINGETTKNMKH 1211 Query: 154 EKAVELLKAAQGKVKLVVR 172 +A+EL+K +V+L ++ Sbjct: 1212 SRAIELIKNGGRRVRLFLK 1230 Score = 48.9 bits (115), Expect = 3e-06 Identities = 35/92 (38%), Positives = 45/92 (48%), Gaps = 13/92 (14%) Query: 91 PRVVELPKTE-EGLGFNIMGGKEQNS------------PIYISRIIPGGIADRHGGLKRG 137 P VE+ + E EG GF I+ + P I RII G ADR G LK G Sbjct: 996 PYDVEIRRGENEGFGFVIVSSVSRPEAGTTFGNACVAMPHKIGRIIEGSPADRCGKLKVG 1055 Query: 138 DQLLSVNGVSVEGEHHEKAVELLKAAQGKVKL 169 D++L+VNG S+ + H V L+K A V L Sbjct: 1056 DRILAVNGCSITNKSHSDIVNLIKEAGNTVTL 1087 Score = 44.3 bits (103), Expect = 7e-05 Identities = 21/68 (30%), Positives = 38/68 (55%) Query: 95 ELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHE 154 +L K+ G GF ++GG E + + I ++ G A G ++ GD ++SVN V G H Sbjct: 474 KLRKSSRGFGFTVVGGDEPDEFLQIKSLVLDGPAALDGKMETGDVIVSVNDTCVLGHTHA 533 Query: 155 KAVELLKA 162 + V++ ++ Sbjct: 534 QVVKIFQS 541 Score = 28.5 bits (62), Expect = 3.9 Identities = 22/70 (31%), Positives = 34/70 (48%), Gaps = 10/70 (14%) Query: 94 VELPKTEEGLGFNIM---GGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 V + K G GF I GG Q + +I+ + R GLK GD ++ VN +V+ Sbjct: 644 VHIVKGPMGFGFTIADSPGGGGQR----VKQIVD---SPRCRGLKEGDLIVEVNKKNVQA 696 Query: 151 EHHEKAVELL 160 H + V++L Sbjct: 697 LTHNQVVDML 706 >gi|31742501 sorting nexin family member 27 [Homo sapiens] Length = 528 Score = 68.9 bits (167), Expect = 3e-12 Identities = 36/101 (35%), Positives = 59/101 (58%), Gaps = 13/101 (12%) Query: 87 GHSHPRVVELPKTEEGLGFNIMGGKEQNSPI------------YISRIIPGGIADRHGGL 134 G PRVV + K+E G GFN+ G + + ++S ++PGG ADR G+ Sbjct: 37 GGGGPRVVRIVKSESGYGFNVRGQVSEGGQLRSINGELYAPLQHVSAVLPGGAADR-AGV 95 Query: 135 KRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTP 175 ++GD++L VN V+VEG H++ V+L++A + ++ L V P Sbjct: 96 RKGDRILEVNHVNVEGATHKQVVDLIRAGEKELILTVLSVP 136 >gi|5453992 protein tyrosine phosphatase, non-receptor type 13 isoform 2 [Homo sapiens] Length = 2466 Score = 68.6 bits (166), Expect = 3e-12 Identities = 46/139 (33%), Positives = 72/139 (51%), Gaps = 18/139 (12%) Query: 63 ISSSPEVRANATAKATVA----AFAASEGHSHPRVVELPKTE-----------EGLGFNI 107 ++ SPE R + + +++ A+ H +V P+ E GLGF I Sbjct: 1030 LNRSPERRKHESDSSSIEDPGQAYVLDVLHKRWSIVSSPEREITLVNLKKDAKYGLGFQI 1089 Query: 108 MGGKEQNS---PIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQ 164 +GG++ I+IS + PGG AD G LK GD+L+SVN VS+EG H A+E+L+ A Sbjct: 1090 IGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIEILQNAP 1149 Query: 165 GKVKLVVRYTPKVLEEMES 183 V LV+ + + ++ S Sbjct: 1150 EDVTLVISQPKEKISKVPS 1168 Score = 62.4 bits (150), Expect = 2e-10 Identities = 32/81 (39%), Positives = 51/81 (62%), Gaps = 3/81 (3%) Query: 94 VELPKTEEGLGFNIMGGKE---QNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 VEL K + LG ++ GG ++ IY+ +IP G A+ G + +GD++L+VNGVS+EG Sbjct: 1350 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1409 Query: 151 EHHEKAVELLKAAQGKVKLVV 171 H++AVE L+ V L++ Sbjct: 1410 ATHKQAVETLRNTGQVVHLLL 1430 Score = 44.3 bits (103), Expect = 7e-05 Identities = 31/80 (38%), Positives = 43/80 (53%), Gaps = 3/80 (3%) Query: 93 VVELPKTEEG-LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 ++ L K+E+G LGF + G Q Y+ +I A G LK GD+L+ VN V Sbjct: 1769 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1826 Query: 152 HHEKAVELLKAAQGKVKLVV 171 H AV LL+AA V+LV+ Sbjct: 1827 THTDAVNLLRAASKTVRLVI 1846 Score = 43.9 bits (102), Expect = 9e-05 Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 7/97 (7%) Query: 94 VELPKTEEGLGF------NIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVS 147 V+L K GLGF N++ + S + + ++ PG A G + GD +L VNG S Sbjct: 1483 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1542 Query: 148 VEGEHHEKAVELLKAAQGKVKLVV-RYTPKVLEEMES 183 ++G ++ + L+ +V L++ R P VL E+++ Sbjct: 1543 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDT 1579 Score = 36.6 bits (83), Expect = 0.014 Identities = 22/58 (37%), Positives = 32/58 (55%), Gaps = 1/58 (1%) Query: 94 VELPKTEEGLGFNIMGGKEQ-NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 + L +E LGF++ GG + +YIS I P +A G L+ D + VNGVS +G Sbjct: 1865 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQG 1922 >gi|5803177 basic beta 2 syntrophin [Homo sapiens] Length = 540 Score = 67.8 bits (164), Expect = 6e-12 Identities = 42/97 (43%), Positives = 57/97 (58%), Gaps = 2/97 (2%) Query: 83 AASEGHSHP-RVVELPKTEEG-LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQL 140 A G S P R V + K E G LG +I GG+E PI IS+I PG AD+ L+ GD + Sbjct: 104 AGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAI 163 Query: 141 LSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKV 177 LSVNG + H++AV+ LK A +V L V++ +V Sbjct: 164 LSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREV 200 >gi|18375650 protein tyrosine phosphatase, non-receptor type 13 isoform 4 [Homo sapiens] Length = 2490 Score = 67.4 bits (163), Expect = 8e-12 Identities = 37/85 (43%), Positives = 53/85 (62%), Gaps = 3/85 (3%) Query: 102 GLGFNIMGGKEQNS---PIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVE 158 GLGF I+GG++ I+IS + PGG AD G LK GD+L+SVN VS+EG H A+E Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162 Query: 159 LLKAAQGKVKLVVRYTPKVLEEMES 183 +L+ A V LV+ + + ++ S Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPS 1187 Score = 56.2 bits (134), Expect = 2e-08 Identities = 32/86 (37%), Positives = 51/86 (59%), Gaps = 8/86 (9%) Query: 94 VELPKTEEGLGFNIM-----GGKE---QNSPIYISRIIPGGIADRHGGLKRGDQLLSVNG 145 VEL K + LG ++ GG ++ IY+ +IP G A+ G + +GD++L+VNG Sbjct: 1369 VELAKNDNSLGISVTVLFDKGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNG 1428 Query: 146 VSVEGEHHEKAVELLKAAQGKVKLVV 171 VS+EG H++AVE L+ V L++ Sbjct: 1429 VSLEGATHKQAVETLRNTGQVVHLLL 1454 Score = 44.3 bits (103), Expect = 7e-05 Identities = 31/80 (38%), Positives = 43/80 (53%), Gaps = 3/80 (3%) Query: 93 VVELPKTEEG-LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 ++ L K+E+G LGF + G Q Y+ +I A G LK GD+L+ VN V Sbjct: 1793 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1850 Query: 152 HHEKAVELLKAAQGKVKLVV 171 H AV LL+AA V+LV+ Sbjct: 1851 THTDAVNLLRAASKTVRLVI 1870 Score = 43.9 bits (102), Expect = 9e-05 Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 7/97 (7%) Query: 94 VELPKTEEGLGF------NIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVS 147 V+L K GLGF N++ + S + + ++ PG A G + GD +L VNG S Sbjct: 1507 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1566 Query: 148 VEGEHHEKAVELLKAAQGKVKLVV-RYTPKVLEEMES 183 ++G ++ + L+ +V L++ R P VL E+++ Sbjct: 1567 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDT 1603 Score = 36.6 bits (83), Expect = 0.014 Identities = 22/58 (37%), Positives = 32/58 (55%), Gaps = 1/58 (1%) Query: 94 VELPKTEEGLGFNIMGGKEQ-NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 + L +E LGF++ GG + +YIS I P +A G L+ D + VNGVS +G Sbjct: 1889 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQG 1946 >gi|18375648 protein tyrosine phosphatase, non-receptor type 13 isoform 3 [Homo sapiens] Length = 2294 Score = 67.4 bits (163), Expect = 8e-12 Identities = 37/85 (43%), Positives = 53/85 (62%), Gaps = 3/85 (3%) Query: 102 GLGFNIMGGKEQNS---PIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVE 158 GLGF I+GG++ I+IS + PGG AD G LK GD+L+SVN VS+EG H A+E Sbjct: 912 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 971 Query: 159 LLKAAQGKVKLVVRYTPKVLEEMES 183 +L+ A V LV+ + + ++ S Sbjct: 972 ILQNAPEDVTLVISQPKEKISKVPS 996 Score = 62.4 bits (150), Expect = 2e-10 Identities = 32/81 (39%), Positives = 51/81 (62%), Gaps = 3/81 (3%) Query: 94 VELPKTEEGLGFNIMGGKE---QNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 VEL K + LG ++ GG ++ IY+ +IP G A+ G + +GD++L+VNGVS+EG Sbjct: 1178 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1237 Query: 151 EHHEKAVELLKAAQGKVKLVV 171 H++AVE L+ V L++ Sbjct: 1238 ATHKQAVETLRNTGQVVHLLL 1258 Score = 44.3 bits (103), Expect = 7e-05 Identities = 31/80 (38%), Positives = 43/80 (53%), Gaps = 3/80 (3%) Query: 93 VVELPKTEEG-LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 ++ L K+E+G LGF + G Q Y+ +I A G LK GD+L+ VN V Sbjct: 1597 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1654 Query: 152 HHEKAVELLKAAQGKVKLVV 171 H AV LL+AA V+LV+ Sbjct: 1655 THTDAVNLLRAASKTVRLVI 1674 Score = 43.9 bits (102), Expect = 9e-05 Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 7/97 (7%) Query: 94 VELPKTEEGLGF------NIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVS 147 V+L K GLGF N++ + S + + ++ PG A G + GD +L VNG S Sbjct: 1311 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1370 Query: 148 VEGEHHEKAVELLKAAQGKVKLVV-RYTPKVLEEMES 183 ++G ++ + L+ +V L++ R P VL E+++ Sbjct: 1371 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDT 1407 Score = 36.6 bits (83), Expect = 0.014 Identities = 22/58 (37%), Positives = 32/58 (55%), Gaps = 1/58 (1%) Query: 94 VELPKTEEGLGFNIMGGKEQ-NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 + L +E LGF++ GG + +YIS I P +A G L+ D + VNGVS +G Sbjct: 1693 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQG 1750 >gi|18375646 protein tyrosine phosphatase, non-receptor type 13 isoform 1 [Homo sapiens] Length = 2485 Score = 67.4 bits (163), Expect = 8e-12 Identities = 37/85 (43%), Positives = 53/85 (62%), Gaps = 3/85 (3%) Query: 102 GLGFNIMGGKEQNS---PIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVE 158 GLGF I+GG++ I+IS + PGG AD G LK GD+L+SVN VS+EG H A+E Sbjct: 1103 GLGFQIIGGEKMGRLDLGIFISSVAPGGPADLDGCLKPGDRLISVNSVSLEGVSHHAAIE 1162 Query: 159 LLKAAQGKVKLVVRYTPKVLEEMES 183 +L+ A V LV+ + + ++ S Sbjct: 1163 ILQNAPEDVTLVISQPKEKISKVPS 1187 Score = 62.4 bits (150), Expect = 2e-10 Identities = 32/81 (39%), Positives = 51/81 (62%), Gaps = 3/81 (3%) Query: 94 VELPKTEEGLGFNIMGGKE---QNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 VEL K + LG ++ GG ++ IY+ +IP G A+ G + +GD++L+VNGVS+EG Sbjct: 1369 VELAKNDNSLGISVTGGVNTSVRHGGIYVKAVIPQGAAESDGRIHKGDRVLAVNGVSLEG 1428 Query: 151 EHHEKAVELLKAAQGKVKLVV 171 H++AVE L+ V L++ Sbjct: 1429 ATHKQAVETLRNTGQVVHLLL 1449 Score = 44.3 bits (103), Expect = 7e-05 Identities = 31/80 (38%), Positives = 43/80 (53%), Gaps = 3/80 (3%) Query: 93 VVELPKTEEG-LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 ++ L K+E+G LGF + G Q Y+ +I A G LK GD+L+ VN V Sbjct: 1788 LITLIKSEKGSLGFTVTKGN-QRIGCYVHDVIQDP-AKSDGRLKPGDRLIKVNDTDVTNM 1845 Query: 152 HHEKAVELLKAAQGKVKLVV 171 H AV LL+AA V+LV+ Sbjct: 1846 THTDAVNLLRAASKTVRLVI 1865 Score = 43.9 bits (102), Expect = 9e-05 Identities = 29/97 (29%), Positives = 51/97 (52%), Gaps = 7/97 (7%) Query: 94 VELPKTEEGLGF------NIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVS 147 V+L K GLGF N++ + S + + ++ PG A G + GD +L VNG S Sbjct: 1502 VKLFKNSSGLGFSFSREDNLIPEQINASIVRVKKLFPGQPAAESGKIDVGDVILKVNGAS 1561 Query: 148 VEGEHHEKAVELLKAAQGKVKLVV-RYTPKVLEEMES 183 ++G ++ + L+ +V L++ R P VL E+++ Sbjct: 1562 LKGLSQQEVISALRGTAPEVFLLLCRPPPGVLPEIDT 1598 Score = 36.6 bits (83), Expect = 0.014 Identities = 22/58 (37%), Positives = 32/58 (55%), Gaps = 1/58 (1%) Query: 94 VELPKTEEGLGFNIMGGKEQ-NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 + L +E LGF++ GG + +YIS I P +A G L+ D + VNGVS +G Sbjct: 1884 ITLTCNKEELGFSLCGGHDSLYQVVYISDINPRSVAAIEGNLQLLDVIHYVNGVSTQG 1941 >gi|7706025 PDZ domain containing 11 [Homo sapiens] Length = 140 Score = 66.2 bits (160), Expect = 2e-11 Identities = 39/86 (45%), Positives = 53/86 (61%), Gaps = 3/86 (3%) Query: 91 PRVVELPKTEEG-LGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVE 149 PR + L K LGFNI GGK I+IS++IP A R GL+ GDQ+L+VN V + Sbjct: 45 PRTITLKKPPGAQLGFNIRGGKASQLGIFISKVIPDSDAHR-AGLQEGDQVLAVNDVDFQ 103 Query: 150 GEHHEKAVELLKAAQGKVKLVVRYTP 175 H KAVE+LK A+ ++ + VR+ P Sbjct: 104 DIEHSKAVEILKTAR-EISMRVRFFP 128 >gi|112382257 InaD-like [Homo sapiens] Length = 1801 Score = 65.9 bits (159), Expect = 2e-11 Identities = 33/86 (38%), Positives = 50/86 (58%), Gaps = 2/86 (2%) Query: 90 HPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVE 149 H VEL GLGF I+GGK S + + I+PGG+ADR G L+ GD +L + G +V+ Sbjct: 245 HVEEVELINDGSGLGFGIVGGK--TSGVVVRTIVPGGLADRDGRLQTGDHILKIGGTNVQ 302 Query: 150 GEHHEKAVELLKAAQGKVKLVVRYTP 175 G E+ ++L+ V+++V P Sbjct: 303 GMTSEQVAQVLRNCGNSVRMLVARDP 328 Score = 61.6 bits (148), Expect = 4e-10 Identities = 33/80 (41%), Positives = 47/80 (58%), Gaps = 1/80 (1%) Query: 93 VVELPKTEEGLGFNIMGGKEQN-SPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 ++E+ K GLG +I+GGK+ + I I + G A R G L GDQ+L VNGV + Sbjct: 1437 IIEISKGRSGLGLSIVGGKDTPLNAIVIHEVYEEGAAARDGRLWAGDQILEVNGVDLRNS 1496 Query: 152 HHEKAVELLKAAQGKVKLVV 171 HE+A+ L+ KV+LVV Sbjct: 1497 SHEEAITALRQTPQKVRLVV 1516 Score = 60.5 bits (145), Expect = 9e-10 Identities = 33/74 (44%), Positives = 44/74 (59%), Gaps = 1/74 (1%) Query: 98 KTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAV 157 K GLG +I+G K S ++IS I+ GG AD G L +GDQ+LSVNG + E Sbjct: 1539 KAGRGLGLSIVG-KRNGSGVFISDIVKGGAADLDGRLIQGDQILSVNGEDMRNASQETVA 1597 Query: 158 ELLKAAQGKVKLVV 171 +LK AQG V+L + Sbjct: 1598 TILKCAQGLVQLEI 1611 Score = 56.6 bits (135), Expect = 1e-08 Identities = 32/90 (35%), Positives = 51/90 (56%), Gaps = 3/90 (3%) Query: 82 FAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNS-PIYISRIIPGGIADRHGGLKRGDQL 140 +A G H ++EL K + GLG ++ G K+++ I++ I P G A G ++ GD+L Sbjct: 1230 YADLPGELH--IIELEKDKNGLGLSLAGNKDRSRMSIFVVGINPEGPAAADGRMRIGDEL 1287 Query: 141 LSVNGVSVEGEHHEKAVELLKAAQGKVKLV 170 L +N + G H+ A ++K A KVKLV Sbjct: 1288 LEINNQILYGRSHQNASAIIKTAPSKVKLV 1317 Score = 55.1 bits (131), Expect = 4e-08 Identities = 32/85 (37%), Positives = 50/85 (58%), Gaps = 4/85 (4%) Query: 91 PRVVELPKT-EEGLGFNIMGGKEQ---NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGV 146 PR VE+ + + LG +I GG+ + P++I+ I G+A R LK GD+++S+NG Sbjct: 1674 PRTVEINRELSDALGISIAGGRGSPLGDIPVFIAMIQASGVAARTQKLKVGDRIVSINGQ 1733 Query: 147 SVEGEHHEKAVELLKAAQGKVKLVV 171 ++G H V LLK A G++ L V Sbjct: 1734 PLDGLSHADVVNLLKNAYGRIILQV 1758 Score = 53.5 bits (127), Expect = 1e-07 Identities = 33/111 (29%), Positives = 60/111 (54%), Gaps = 13/111 (11%) Query: 91 PRVVELPKTEE-GLGFNIMGGK---------EQNSPIYISRIIPGGIADRHGGLKRGDQL 140 PR+VE+ + LG +I+GG+ E+ I+I +++ A + LK GD++ Sbjct: 1066 PRIVEIFREPNVSLGISIVGGQTVIKRLKNGEELKGIFIKQVLEDSPAGKTNALKTGDKI 1125 Query: 141 LSVNGVSVEGEHHEKAVELLKAAQGKVKLVVR---YTPKVLEEMESRFEKM 188 L V+GV ++ H +AVE +K A V +V+ TP+V+ + ++ K+ Sbjct: 1126 LEVSGVDLQNASHSEAVEAIKNAGNPVVFIVQSLSSTPRVIPNVHNKANKI 1176 Score = 53.1 bits (126), Expect = 1e-07 Identities = 30/75 (40%), Positives = 47/75 (62%), Gaps = 4/75 (5%) Query: 92 RVVELPKTEEGLGFNIMGGKEQNSP----IYISRIIPGGIADRHGGLKRGDQLLSVNGVS 147 ++VEL K +GLGF+I+ ++ P I I ++ G+A+R GGL GD+L+SVN Sbjct: 685 KIVELVKDCKGLGFSILDYQDPLDPTRSVIVIRSLVADGVAERSGGLLPGDRLVSVNEYC 744 Query: 148 VEGEHHEKAVELLKA 162 ++ +AVE+LKA Sbjct: 745 LDNTSLAEAVEILKA 759 Score = 52.8 bits (125), Expect = 2e-07 Identities = 29/86 (33%), Positives = 50/86 (58%), Gaps = 5/86 (5%) Query: 94 VELPKTEEGLGFNIMGGKEQNS---PIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 +E P T GLGF+++ + QN I++ + PG +ADR LK DQ+L++N ++ Sbjct: 137 IERPSTG-GLGFSVVALRSQNLGKVDIFVKDVQPGSVADRDQRLKENDQILAINHTPLDQ 195 Query: 151 E-HHEKAVELLKAAQGKVKLVVRYTP 175 H++A+ LL+ G ++L+V P Sbjct: 196 NISHQQAIALLQQTTGSLRLIVAREP 221 Score = 42.4 bits (98), Expect = 3e-04 Identities = 25/79 (31%), Positives = 44/79 (55%), Gaps = 5/79 (6%) Query: 98 KTEEGLGFNIMG-----GKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEH 152 K + LG I+G + S IY+ IIPG A +G ++ D++++V+GV+++G Sbjct: 371 KDGQSLGIRIVGYVGTSHTGEASGIYVKSIIPGSAAYHNGHIQVNDKIVAVDGVNIQGFA 430 Query: 153 HEKAVELLKAAQGKVKLVV 171 + VE+L+ A V L + Sbjct: 431 NHDVVEVLRNAGQVVHLTL 449 Score = 40.8 bits (94), Expect = 8e-04 Identities = 41/161 (25%), Positives = 67/161 (41%), Gaps = 31/161 (19%) Query: 10 LERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISSSPEV 69 L+ D +A+E LEK+ S E L+S + N + YE + T+D + + Sbjct: 505 LKNDNIQALEKLEKVPDSPE----------NELKSRWENLLGPDYEVMVATLDTQIADD- 553 Query: 70 RANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIAD 129 +E + +++ + G+ + G YIS I+ GG D Sbjct: 554 ---------------AELQKYSKLLPIHTLRLGVEVDSFDGHH-----YISSIVSGGPVD 593 Query: 130 RHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLV 170 G L+ D+LL VNG+ + G+ +AV LK LV Sbjct: 594 TLGLLQPEDELLEVNGMQLYGKSRREAVSFLKEVPPPFTLV 634 >gi|27436957 membrane associated guanylate kinase, WW and PDZ domain containing 2 [Homo sapiens] Length = 1455 Score = 65.5 bits (158), Expect = 3e-11 Identities = 35/81 (43%), Positives = 47/81 (58%), Gaps = 2/81 (2%) Query: 94 VELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHH 153 V L + E G GF I+GG E PI I +I G ADR G L GD+L+ V+G+ V G+ H Sbjct: 779 VHLRRMESGFGFRILGGDEPGQPILIGAVIAMGSADRDGRLHPGDELVYVDGIPVAGKTH 838 Query: 154 EKAVELL--KAAQGKVKLVVR 172 ++L+ A G+V L VR Sbjct: 839 RYVIDLMHHAARNGQVNLTVR 859 Score = 64.3 bits (155), Expect = 6e-11 Identities = 28/79 (35%), Positives = 51/79 (64%) Query: 94 VELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHH 153 V++ K +G GF+I GG+E +Y+ R+ G A R+G ++ GDQ++ +NG S H Sbjct: 1148 VDMEKGAKGFGFSIRGGREYKMDLYVLRLAEDGPAIRNGRMRVGDQIIEINGESTRDMTH 1207 Query: 154 EKAVELLKAAQGKVKLVVR 172 +A+EL+K+ +V+L+++ Sbjct: 1208 ARAIELIKSGGRRVRLLLK 1226 Score = 47.8 bits (112), Expect = 6e-06 Identities = 23/67 (34%), Positives = 38/67 (56%) Query: 96 LPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEK 155 L K+ G GF I+GG E + + + +IP G A + G ++ GD ++ +N V V G H Sbjct: 429 LKKSNMGFGFTIIGGDEPDEFLQVKSVIPDGPAAQDGKMETGDVIVYINEVCVLGHTHAD 488 Query: 156 AVELLKA 162 V+L ++ Sbjct: 489 VVKLFQS 495 Score = 46.2 bits (108), Expect = 2e-05 Identities = 37/103 (35%), Positives = 50/103 (48%), Gaps = 11/103 (10%) Query: 98 KTEEGLGFNIMG-------GKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEG 150 K EG GF I+ G P I RII G ADR LK GD++L+VNG S+ Sbjct: 926 KENEGFGFVIISSLNRPESGSTITVPHKIGRIIDGSPADRCAKLKVGDRILAVNGQSIIN 985 Query: 151 EHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKR 193 H V+L+K A + + +R P+ EE+ S S K+ Sbjct: 986 MPHADIVKLIKDA--GLSVTLRIIPQ--EELNSPTSAPSSEKQ 1024 Score = 31.6 bits (70), Expect = 0.46 Identities = 21/71 (29%), Positives = 32/71 (45%), Gaps = 1/71 (1%) Query: 100 EEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGG-LKRGDQLLSVNGVSVEGEHHEKAVE 158 E LGF + GG E Y+ + PG +A G L + LL VN V G + Sbjct: 25 EGQLGFELKGGAENGQFPYLGEVKPGKVAYESGSKLVSEELLLEVNETPVAGLTIRDVLA 84 Query: 159 LLKAAQGKVKL 169 ++K + ++L Sbjct: 85 VIKHCKDPLRL 95 >gi|21361831 partitioning-defective protein 3 homolog [Homo sapiens] Length = 1356 Score = 65.5 bits (158), Expect = 3e-11 Identities = 46/144 (31%), Positives = 76/144 (52%), Gaps = 21/144 (14%) Query: 71 ANATAKATVAAFAASEGHSHPRV-----VELPKTEEGLGFNI------MGGKEQNSPIYI 119 A A+A V + S G++ ++ ++L K EGLGF+I +GG ++PIY+ Sbjct: 434 APASAPQNVFSTTVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGG---SAPIYV 490 Query: 120 SRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAA--QGKVKLVV-----R 172 I+P G A + G LK GD+L+ VNGV + G+ E+ V LL++ +G V L+V Sbjct: 491 KNILPRGAAIQDGRLKAGDRLIEVNGVDLVGKSQEEVVSLLRSTKMEGTVSLLVFRQEDA 550 Query: 173 YTPKVLEEMESRFEKMRSAKRRQQ 196 + P+ L S+ + + K + Sbjct: 551 FHPRELNAEPSQMQIPKETKAEDE 574 Score = 47.0 bits (110), Expect = 1e-05 Identities = 28/93 (30%), Positives = 52/93 (55%), Gaps = 11/93 (11%) Query: 102 GLGFNIMGGKEQNSP----IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAV 157 GLG ++ G + + + I++ II GG A + G L+ DQL++VNG S+ G+ ++ A+ Sbjct: 600 GLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAM 659 Query: 158 ELLKAA-------QGKVKLVVRYTPKVLEEMES 183 E L+ + +G ++L+V E++S Sbjct: 660 ETLRRSMSTEGNKRGMIQLIVARRISKCNELKS 692 >gi|45827729 scribble isoform b [Homo sapiens] Length = 1630 Score = 65.1 bits (157), Expect = 4e-11 Identities = 36/82 (43%), Positives = 51/82 (62%), Gaps = 6/82 (7%) Query: 96 LPKTEEGLGFNIMGGKEQ------NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVE 149 L ++E GLGF+I GGK ++ I++SRI GG A R G L+ GD++LS+NGV V Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924 Query: 150 GEHHEKAVELLKAAQGKVKLVV 171 H+ AV LL AA + L++ Sbjct: 925 EARHDHAVSLLTAASPTIALLL 946 Score = 57.8 bits (138), Expect = 6e-09 Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 23/133 (17%) Query: 65 SSPEVRANATAKATVAA--------------FAASEGHSHPRVVELPKTEEGLGFNIMGG 110 SSP A AT T A AA EG + LP+ LG +I+GG Sbjct: 962 SSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGG 1021 Query: 111 KEQNSP--------IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKA 162 + +S ++IS+++P G+A R GL+ GD++L+VNG V H++AV L Sbjct: 1022 SDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080 Query: 163 AQGKVKLVVRYTP 175 ++ L+VR P Sbjct: 1081 PCLELSLLVRRDP 1093 Score = 52.8 bits (125), Expect = 2e-07 Identities = 36/115 (31%), Positives = 59/115 (51%), Gaps = 7/115 (6%) Query: 63 ISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQ------NSP 116 + S+P V+ + +A + + + + GLG +I GGK + Sbjct: 698 VVSAPSVKGVSFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEG 757 Query: 117 IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 I+ISR+ G A R G++ GD+LL VNGV+++G H +AVE L+ A V++ V Sbjct: 758 IFISRVSEEGPAAR-AGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRV 811 Score = 42.4 bits (98), Expect = 3e-04 Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 9/80 (11%) Query: 101 EGLGFNIMGGKEQNSP---------IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 E LG +I GG ++ I+IS++ P G A R G L+ G +LL VN S+ G Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168 Query: 152 HHEKAVELLKAAQGKVKLVV 171 H +AV+LL++ + ++V Sbjct: 1169 THGEAVQLLRSVGDTLTVLV 1188 >gi|45827731 scribble isoform a [Homo sapiens] Length = 1655 Score = 65.1 bits (157), Expect = 4e-11 Identities = 36/82 (43%), Positives = 51/82 (62%), Gaps = 6/82 (7%) Query: 96 LPKTEEGLGFNIMGGKEQ------NSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVE 149 L ++E GLGF+I GGK ++ I++SRI GG A R G L+ GD++LS+NGV V Sbjct: 865 LARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVT 924 Query: 150 GEHHEKAVELLKAAQGKVKLVV 171 H+ AV LL AA + L++ Sbjct: 925 EARHDHAVSLLTAASPTIALLL 946 Score = 57.8 bits (138), Expect = 6e-09 Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 23/133 (17%) Query: 65 SSPEVRANATAKATVAA--------------FAASEGHSHPRVVELPKTEEGLGFNIMGG 110 SSP A AT T A AA EG + LP+ LG +I+GG Sbjct: 962 SSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGG 1021 Query: 111 KEQNSP--------IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKA 162 + +S ++IS+++P G+A R GL+ GD++L+VNG V H++AV L Sbjct: 1022 SDHSSHPFGVQEPGVFISKVLPRGLAAR-SGLRVGDRILAVNGQDVRDATHQEAVSALLR 1080 Query: 163 AQGKVKLVVRYTP 175 ++ L+VR P Sbjct: 1081 PCLELSLLVRRDP 1093 Score = 52.8 bits (125), Expect = 2e-07 Identities = 36/115 (31%), Positives = 59/115 (51%), Gaps = 7/115 (6%) Query: 63 ISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQ------NSP 116 + S+P V+ + +A + + + + GLG +I GGK + Sbjct: 698 VVSAPSVKGVSFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEG 757 Query: 117 IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVV 171 I+ISR+ G A R G++ GD+LL VNGV+++G H +AVE L+ A V++ V Sbjct: 758 IFISRVSEEGPAAR-AGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRV 811 Score = 42.4 bits (98), Expect = 3e-04 Identities = 28/80 (35%), Positives = 44/80 (55%), Gaps = 9/80 (11%) Query: 101 EGLGFNIMGGKEQNSP---------IYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGE 151 E LG +I GG ++ I+IS++ P G A R G L+ G +LL VN S+ G Sbjct: 1109 ERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGL 1168 Query: 152 HHEKAVELLKAAQGKVKLVV 171 H +AV+LL++ + ++V Sbjct: 1169 THGEAVQLLRSVGDTLTVLV 1188 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.131 0.361 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 6,902,113 Number of Sequences: 37866 Number of extensions: 283497 Number of successful extensions: 1152 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 190 Number of HSP's successfully gapped in prelim test: 29 Number of HSP's that attempted gapping in prelim test: 700 Number of HSP's gapped (non-prelim): 378 length of query: 197 length of database: 18,247,518 effective HSP length: 97 effective length of query: 100 effective length of database: 14,574,516 effective search space: 1457451600 effective search space used: 1457451600 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 59 (27.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.