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Search of human proteins with 83779014
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
(655 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 1323 0.0
gi|26665869 WD repeat domain 51B [Homo sapiens] 139 8e-33
gi|21071067 TBP-associated factor 5 [Homo sapiens] 137 3e-32
gi|32189425 WD repeat domain 69 [Homo sapiens] 132 1e-30
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 130 3e-30
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 129 1e-29
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 129 1e-29
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 129 1e-29
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 128 2e-29
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 127 3e-29
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 126 7e-29
gi|16554629 WD repeat domain 5 [Homo sapiens] 123 6e-28
gi|16554627 WD repeat domain 5 [Homo sapiens] 123 6e-28
gi|23199987 WD repeat domain 5B [Homo sapiens] 123 6e-28
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 121 2e-27
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 121 2e-27
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 121 2e-27
gi|113865883 WD repeat domain 38 [Homo sapiens] 119 1e-26
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 116 7e-26
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 115 1e-25
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 110 3e-24
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 110 3e-24
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 110 3e-24
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 108 1e-23
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 106 8e-23
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 106 8e-23
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 104 3e-22
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 103 7e-22
gi|20336270 guanine nucleotide-binding protein, beta-5 subunit i... 103 7e-22
gi|13376840 WD repeat domain 61 [Homo sapiens] 102 9e-22
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 1323 bits (3424), Expect = 0.0
Identities = 655/655 (100%), Positives = 655/655 (100%)
Query: 1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLT 60
MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLT
Sbjct: 1 MATPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLT 60
Query: 61 GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV 120
GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV
Sbjct: 61 GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV 120
Query: 121 ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK 180
ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK
Sbjct: 121 ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK 180
Query: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN 240
MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN
Sbjct: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN 240
Query: 241 PDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVV 300
PDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVV
Sbjct: 241 PDGCCLYSGCQDSLRVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVV 300
Query: 301 DLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYERPSTTCSKPQRVKQNSESERRS 360
DLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYERPSTTCSKPQRVKQNSESERRS
Sbjct: 301 DLTRVTRTGTVARDPVQDHRPLAQPLPNPSAPLRRIYERPSTTCSKPQRVKQNSESERRS 360
Query: 361 PSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATAKEAAKP 420
PSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATAKEAAKP
Sbjct: 361 PSSEDDRDERESRAEIQNAEDYNEIFQPKNSISRTPPRRSEPFPAPPEDDAATAKEAAKP 420
Query: 421 SPAMDVQFPVPNLEVLPRPPVVASTPAPKAEPAIIPATRNEPIGLKASDFLPAVKIPQQA 480
SPAMDVQFPVPNLEVLPRPPVVASTPAPKAEPAIIPATRNEPIGLKASDFLPAVKIPQQA
Sbjct: 421 SPAMDVQFPVPNLEVLPRPPVVASTPAPKAEPAIIPATRNEPIGLKASDFLPAVKIPQQA 480
Query: 481 ELVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWTMGDIKTSVDSAVAINDLSVVVDL 540
ELVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWTMGDIKTSVDSAVAINDLSVVVDL
Sbjct: 481 ELVDEDAMSQIRKGHDTMCVVLTSRHKNLDTVRAVWTMGDIKTSVDSAVAINDLSVVVDL 540
Query: 541 LNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITDMLAAP 600
LNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITDMLAAP
Sbjct: 541 LNIVNQKASLWKLDLCTTVLPQIEKLLQSKYESYVQTGCTSLKLILQRFLPLITDMLAAP 600
Query: 601 PSVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFRELHLLMASLD 655
PSVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFRELHLLMASLD
Sbjct: 601 PSVGVDISREERLHKCRLCYKQLKSISGLVKSKSGLSGRHGSTFRELHLLMASLD 655
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 139 bits (350), Expect = 8e-33
Identities = 77/237 (32%), Positives = 118/237 (49%), Gaps = 1/237 (0%)
Query: 17 VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEE 76
V H V+S+ G LLA+ D V LW +K HT+PV SV + +
Sbjct: 57 VGHKDVVTSVQFSP-HGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQ 115
Query: 77 LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR 136
+ S+ SI+VW + + L +L H + F P G + S S+D IK+WD
Sbjct: 116 FLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTN 175
Query: 137 KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVE 196
K CV + + F+P G +ASA D TVK+WD+ K++ + H+G VN +
Sbjct: 176 KQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCIS 235
Query: 197 FHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
FHP+ L + SSD T++ DL + +++ ++G GPV +V F+ G SG D+
Sbjct: 236 FHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADT 292
Score = 134 bits (336), Expect = 3e-31
Identities = 70/234 (29%), Positives = 124/234 (52%), Gaps = 1/234 (0%)
Query: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
H + ++SL L +G+ LAT D + LW+ GH V SV+ + L+
Sbjct: 17 HKAAITSLDLSP-NGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
+ S+ ++R+W + H A + S+DF G+F+A+ S+D +IK+W + R+
Sbjct: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
Query: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFH 198
++ H+ VRC +FSPDG+ + S ++D T+K+WD T + ++ F G N V+F+
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFN 195
Query: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
P+ +AS SD+T++ WD+ +++ + G V + F+P G L + D
Sbjct: 196 PSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSD 249
Score = 127 bits (319), Expect = 3e-29
Identities = 67/205 (32%), Positives = 104/205 (50%), Gaps = 1/205 (0%)
Query: 12 KLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRL 71
K E AH + V S+ A G+ LAT +D + +WS+ + + SL HT V +
Sbjct: 94 KFSEFKAHTAPVRSVDFS-ADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKF 152
Query: 72 NTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKL 131
+ LIV+ S+ +I++WD + + +DF+P G +AS D +K+
Sbjct: 153 SPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKV 212
Query: 132 WDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
WD+R + Y+ HS V C+ F P G +L +A+ D T+K+ DL G+++ GHTGP
Sbjct: 213 WDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGP 272
Query: 192 VNVVEFHPNEYLLASGSSDRTIRFW 216
V V F L ASG +D + W
Sbjct: 273 VFTVSFSKGGELFASGGADTQVLLW 297
Score = 112 bits (280), Expect = 1e-24
Identities = 57/192 (29%), Positives = 99/192 (51%)
Query: 61 GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV 120
GH + + S+ L+ + + S + +W+ + +GHK + S+ F P+G +
Sbjct: 16 GHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLL 75
Query: 121 ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK 180
AS S+D ++LW ++G ++ H+ VR + FS DG++LA+A++D ++K+W + +
Sbjct: 76 ASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQR 135
Query: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN 240
+ HT V +F P+ L+ S S D+TI+ WD Q V+ G V FN
Sbjct: 136 FLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFN 195
Query: 241 PDGCCLYSGCQD 252
P G C+ S D
Sbjct: 196 PSGTCIASAGSD 207
Score = 108 bits (271), Expect = 1e-23
Identities = 59/167 (35%), Positives = 91/167 (54%), Gaps = 1/167 (0%)
Query: 99 RTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPD 158
R GHKA I SLD P G+ +A+ S DT + LW+ + +RY GH V ++FSP
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71
Query: 159 GKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL 218
G LASA+ D TV+LW SEF HT PV V+F + LA+ S D++I+ W +
Sbjct: 72 GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131
Query: 219 EKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
+ + + + VR F+PDG + S +D +++++ ++C
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 137 bits (345), Expect = 3e-32
Identities = 74/213 (34%), Positives = 109/213 (51%), Gaps = 1/213 (0%)
Query: 8 KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67
KTA +L+ + H+ V LL++ +D V LWS+ C++ GH PV
Sbjct: 531 KTASELKILYGHSGPVYGASFSPDRNYLLSSS-EDGTVRLWSLQTFTCLVGYKGHNYPVW 589
Query: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
+ + V+G R+W + + LR GH A++ FHP +VA+GS D
Sbjct: 590 DTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADR 649
Query: 128 NIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187
++LWD+ CV + GH + L FSP+G++LA+ A D V LWD+ G M+ E G
Sbjct: 650 TVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKG 709
Query: 188 HTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
HT V + F + +LASGS D T+R WD K
Sbjct: 710 HTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 125 bits (315), Expect = 9e-29
Identities = 65/208 (31%), Positives = 105/208 (50%), Gaps = 1/208 (0%)
Query: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE 118
L GH+ PV + +++ S+ G++R+W L+ L GH + F PYG
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 119 FVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178
+ SG D +LW + + GH V C RF P+ ++A+ + D TV+LWD+
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLN 658
Query: 179 GKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVL 238
G + F GH GP++ + F PN LA+G++D + WD+ +V ++G V S+
Sbjct: 659 GNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLR 718
Query: 239 FNPDGCCLYSGCQDSLRVYGWEPERCFD 266
F+ DG L SG D+ V W+ + F+
Sbjct: 719 FSRDGEILASGSMDN-TVRLWDAIKAFE 745
Score = 124 bits (311), Expect = 3e-28
Identities = 71/226 (31%), Positives = 107/226 (47%), Gaps = 12/226 (5%)
Query: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
L+A G D V +WS+ + SV+ + LI S R+ D +
Sbjct: 484 LIAGGFADSTVRVWSVTPKK-----------LRSVKQASDLSLIDKESDDVLERIMDEKT 532
Query: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
A L+ L GH + F P ++ S S+D ++LW ++ C+ Y+GH+ V +
Sbjct: 533 ASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQ 592
Query: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214
FSP G + S D +LW + + F GH VN FHPN +A+GS+DRT+R
Sbjct: 593 FSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
Query: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260
WD+ V G GP+ S+ F+P+G L +G D RV W+
Sbjct: 653 LWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDG-RVLLWD 697
Score = 52.0 bits (123), Expect = 2e-06
Identities = 36/145 (24%), Positives = 53/145 (36%), Gaps = 31/145 (21%)
Query: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSE-------------- 184
C + + Q + + + D +A D TV++W +T K+ S
Sbjct: 462 CFYTFLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESD 521
Query: 185 -----------------FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCI 227
GH+GPV F P+ L S S D T+R W L+ F +
Sbjct: 522 DVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY 581
Query: 228 EGEPGPVRSVLFNPDGCCLYSGCQD 252
+G PV F+P G SG D
Sbjct: 582 KGHNYPVWDTQFSPYGYYFVSGGHD 606
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 132 bits (332), Expect = 1e-30
Identities = 69/219 (31%), Positives = 111/219 (50%)
Query: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
L+ATG D LW I + +L GH++ + S+ NT + I+ GS ++ VWD +
Sbjct: 191 LVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADT 250
Query: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
+ + L+GH A I S F+ + +GS D KLWD CV GH +
Sbjct: 251 GRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSC 310
Query: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214
F GK +A+A+ D T +++ K +++ GH G ++ + F+P L +GSSD+T R
Sbjct: 311 FDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTAR 370
Query: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
WD + Q + +EG + S FN G + +G +D+
Sbjct: 371 IWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDN 409
Score = 130 bits (327), Expect = 4e-30
Identities = 76/273 (27%), Positives = 132/273 (48%), Gaps = 3/273 (1%)
Query: 9 TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVES 68
T + + + AH ++++ L K SG TG D LW + +L GH + V +
Sbjct: 81 TFYLFKVLKAHILPLTNVALNK-SGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYA 139
Query: 69 VRLNTPE-ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
+ N P + I GS + ++W +E K T GH A I L F+P VA+GS DT
Sbjct: 140 IAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDT 199
Query: 128 NIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG 187
KLWDI+ V+ RGHS + L F+ G + + + DHTV +WD G+ ++ G
Sbjct: 200 TAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIG 259
Query: 188 HTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLY 247
H ++ F+ + L+ +GS D+T + WD + V+ + G + F+ G +
Sbjct: 260 HCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIA 319
Query: 248 SGCQD-SLRVYGWEPERCFDVVLVNWGKVADLA 279
+ D + R++ +C + + G+++ ++
Sbjct: 320 TASADGTARIFSAATRKCIAKLEGHEGEISKIS 352
Score = 128 bits (321), Expect = 2e-29
Identities = 73/263 (27%), Positives = 124/263 (47%), Gaps = 1/263 (0%)
Query: 7 TKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPV 66
T + +L + H + V ++ G +ATG D LWS+ C + GHT+ +
Sbjct: 121 TASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEI 180
Query: 67 ESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQD 126
+ N L+ GS + ++WD++ + + TL GH A I SL F+ G+ + +GS D
Sbjct: 181 VCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFD 240
Query: 127 TNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFP 186
+ +WD V GH + F+ D + + + D T KLWD T GK ++
Sbjct: 241 HTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLT 300
Query: 187 GHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCL 246
GH + F L+A+ S+D T R + + ++ +EG G + + FNP G L
Sbjct: 301 GHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHL 360
Query: 247 YSGCQD-SLRVYGWEPERCFDVV 268
+G D + R++ + +C V+
Sbjct: 361 LTGSSDKTARIWDAQTGQCLQVL 383
Score = 104 bits (259), Expect = 3e-22
Identities = 56/216 (25%), Positives = 97/216 (44%), Gaps = 7/216 (3%)
Query: 7 TKTAWKLQE------IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLT 60
T W +Q + H++ + SL + R++ TG D V +W + + L
Sbjct: 200 TAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRII-TGSFDHTVVVWDADTGRKVNILI 258
Query: 61 GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFV 120
GH + + S N LI+ GS + ++WD K + TL GH I F G+ +
Sbjct: 259 GHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLI 318
Query: 121 ASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGK 180
A+ S D +++ + C+ + GH + + F+P G L + + D T ++WD G+
Sbjct: 319 ATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQ 378
Query: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
+ GHT + F+ ++ +GS D T R W
Sbjct: 379 CLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 130 bits (328), Expect = 3e-30
Identities = 67/249 (26%), Positives = 114/249 (45%), Gaps = 1/249 (0%)
Query: 11 WKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVR 70
WKL +++ + + + TG D + +W + +SLTGH S V V
Sbjct: 194 WKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVI 253
Query: 71 LNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIK 130
++T + + + ++ WDLE K++R GH + + LD HP + + + S+D+ +
Sbjct: 254 VSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTAR 313
Query: 131 LWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG 190
+WD+R K V GH+ AV +R + + + D T++LWDL AGK H
Sbjct: 314 IWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKK 373
Query: 191 PVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGC 250
V V HP Y ASGS D I+ W + + G + ++ N DG +
Sbjct: 374 SVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGAD 432
Query: 251 QDSLRVYGW 259
++ ++ W
Sbjct: 433 NGTMHLWDW 441
Score = 90.9 bits (224), Expect = 3e-18
Identities = 58/190 (30%), Positives = 86/190 (45%), Gaps = 10/190 (5%)
Query: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
+L T D +W + + +L+GHT+ V +VR E I+ GS +IR+WDL A
Sbjct: 302 VLVTCSRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVA 361
Query: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
K TL HK ++ ++ HP ASGS D NIK W + GH+ + L
Sbjct: 362 GKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLT 420
Query: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP--------VNVVEFHPNEYLLAS 206
+ DG L S AD+ T+ LWD G P + F +E L +
Sbjct: 421 VNSDGV-LVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFACAFDQSESRLLT 479
Query: 207 GSSDRTIRFW 216
+D+TI+ +
Sbjct: 480 AEADKTIKVY 489
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 129 bits (323), Expect = 1e-29
Identities = 76/237 (32%), Positives = 115/237 (48%), Gaps = 3/237 (1%)
Query: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
SG LLA+G D V +W N HT+ V SV + + V S +++VW
Sbjct: 34 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 93
Query: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
K L +L H + F P G + S S D +KLWD + CV Y H V
Sbjct: 94 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 153
Query: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
+ F P G +A+A D+TVK+WD+ +++ + H+ VN + FHP+ L + SSD
Sbjct: 154 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 213
Query: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVV 268
T++ DL + +++ + G GP +V F+ G SG D +V W+ FD+V
Sbjct: 214 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE-QVMVWKSN--FDIV 267
Score = 122 bits (306), Expect = 1e-27
Identities = 61/199 (30%), Positives = 101/199 (50%), Gaps = 1/199 (0%)
Query: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
AH + V S+ + G+ T DD V +W+ ++ + SL+ H + V + + L
Sbjct: 63 AHTATVRSVHFC-SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121
Query: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
IV+ S ++++WD + + + + H + +DFHP G +A+ D +K+WD+R
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 181
Query: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
+ Y+ HS AV L F P G +L +A+ D T+K+ DL G+++ GH GP V F
Sbjct: 182 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 241
Query: 198 HPNEYLLASGSSDRTIRFW 216
ASG SD + W
Sbjct: 242 SRTGEYFASGGSDEQVMVW 260
Score = 120 bits (301), Expect = 4e-27
Identities = 62/213 (29%), Positives = 104/213 (48%), Gaps = 1/213 (0%)
Query: 41 DDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRT 100
D C + +W + + TGH V V + L+ +GS+ ++R+W
Sbjct: 2 DSCLM-VWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV 60
Query: 101 LMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGK 160
H A + S+ F G+ + S D +K+W R+ +F H VRC +FSPDG+
Sbjct: 61 FRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGR 120
Query: 161 WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
+ SA+DD TVKLWD ++ + + + H G V V+FHP+ +A+ D T++ WD+
Sbjct: 121 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 180
Query: 221 FQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
+++ + V + F+P G L + DS
Sbjct: 181 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 213
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 129 bits (323), Expect = 1e-29
Identities = 76/237 (32%), Positives = 115/237 (48%), Gaps = 3/237 (1%)
Query: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
SG LLA+G D V +W N HT+ V SV + + V S +++VW
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
K L +L H + F P G + S S D +KLWD + CV Y H V
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 191
Query: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
+ F P G +A+A D+TVK+WD+ +++ + H+ VN + FHP+ L + SSD
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
Query: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVV 268
T++ DL + +++ + G GP +V F+ G SG D +V W+ FD+V
Sbjct: 252 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE-QVMVWKSN--FDIV 305
Score = 124 bits (312), Expect = 2e-28
Identities = 64/218 (29%), Positives = 107/218 (49%)
Query: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
LA+G D + +W + + TGH V V + L+ +GS+ ++R+W
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK 93
Query: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155
H A + S+ F G+ + S D +K+W R+ +F H VRC +F
Sbjct: 94 GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF 153
Query: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
SPDG+ + SA+DD TVKLWD ++ + + + H G V V+FHP+ +A+ D T++
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
Query: 216 WDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
WD+ +++ + V + F+P G L + DS
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
Score = 122 bits (306), Expect = 1e-27
Identities = 61/199 (30%), Positives = 101/199 (50%), Gaps = 1/199 (0%)
Query: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
AH + V S+ + G+ T DD V +W+ ++ + SL+ H + V + + L
Sbjct: 101 AHTATVRSVHFC-SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159
Query: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
IV+ S ++++WD + + + + H + +DFHP G +A+ D +K+WD+R
Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
Query: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
+ Y+ HS AV L F P G +L +A+ D T+K+ DL G+++ GH GP V F
Sbjct: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 279
Query: 198 HPNEYLLASGSSDRTIRFW 216
ASG SD + W
Sbjct: 280 SRTGEYFASGGSDEQVMVW 298
Score = 107 bits (267), Expect = 3e-23
Identities = 58/201 (28%), Positives = 93/201 (46%)
Query: 53 PNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLD 112
P+ GH V V + + + +GS + VW ++ GHK + ++
Sbjct: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVN 68
Query: 113 FHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172
F P G +ASGS+D +++W KG +R H+ VR + F DG+ +A+DD TVK
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 173 LWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG 232
+W K + H V +F P+ L+ S S D+T++ WD + V G
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 233 PVRSVLFNPDGCCLYSGCQDS 253
V V F+P G C+ + D+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDN 209
Score = 88.6 bits (218), Expect = 2e-17
Identities = 47/160 (29%), Positives = 77/160 (48%)
Query: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
E + R GH+ + +DF + +ASGS D+ + +W ++ + +R+ GH AV C
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
+ FSP G LAS + D TV++W + F HT V V F + + S D+T
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 213 IRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
++ W + + + + VR F+PDG + S D
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD 166
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 129 bits (323), Expect = 1e-29
Identities = 76/237 (32%), Positives = 115/237 (48%), Gaps = 3/237 (1%)
Query: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
SG LLA+G D V +W N HT+ V SV + + V S +++VW
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
K L +L H + F P G + S S D +KLWD + CV Y H V
Sbjct: 132 THRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVT 191
Query: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
+ F P G +A+A D+TVK+WD+ +++ + H+ VN + FHP+ L + SSD
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
Query: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVV 268
T++ DL + +++ + G GP +V F+ G SG D +V W+ FD+V
Sbjct: 252 TLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDE-QVMVWKSN--FDIV 305
Score = 124 bits (312), Expect = 2e-28
Identities = 64/218 (29%), Positives = 107/218 (49%)
Query: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
LA+G D + +W + + TGH V V + L+ +GS+ ++R+W
Sbjct: 34 LASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVK 93
Query: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155
H A + S+ F G+ + S D +K+W R+ +F H VRC +F
Sbjct: 94 GESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKF 153
Query: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
SPDG+ + SA+DD TVKLWD ++ + + + H G V V+FHP+ +A+ D T++
Sbjct: 154 SPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKV 213
Query: 216 WDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
WD+ +++ + V + F+P G L + DS
Sbjct: 214 WDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDS 251
Score = 122 bits (306), Expect = 1e-27
Identities = 61/199 (30%), Positives = 101/199 (50%), Gaps = 1/199 (0%)
Query: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
AH + V S+ + G+ T DD V +W+ ++ + SL+ H + V + + L
Sbjct: 101 AHTATVRSVHFC-SDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 159
Query: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
IV+ S ++++WD + + + + H + +DFHP G +A+ D +K+WD+R
Sbjct: 160 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTH 219
Query: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
+ Y+ HS AV L F P G +L +A+ D T+K+ DL G+++ GH GP V F
Sbjct: 220 RLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAF 279
Query: 198 HPNEYLLASGSSDRTIRFW 216
ASG SD + W
Sbjct: 280 SRTGEYFASGGSDEQVMVW 298
Score = 107 bits (267), Expect = 3e-23
Identities = 58/201 (28%), Positives = 93/201 (46%)
Query: 53 PNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLD 112
P+ GH V V + + + +GS + VW ++ GHK + ++
Sbjct: 9 PSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVN 68
Query: 113 FHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVK 172
F P G +ASGS+D +++W KG +R H+ VR + F DG+ +A+DD TVK
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVK 128
Query: 173 LWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG 232
+W K + H V +F P+ L+ S S D+T++ WD + V G
Sbjct: 129 VWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGG 188
Query: 233 PVRSVLFNPDGCCLYSGCQDS 253
V V F+P G C+ + D+
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDN 209
Score = 88.6 bits (218), Expect = 2e-17
Identities = 47/160 (29%), Positives = 77/160 (48%)
Query: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
E + R GH+ + +DF + +ASGS D+ + +W ++ + +R+ GH AV C
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTC 66
Query: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
+ FSP G LAS + D TV++W + F HT V V F + + S D+T
Sbjct: 67 VNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKT 126
Query: 213 IRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
++ W + + + + VR F+PDG + S D
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDD 166
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 128 bits (321), Expect = 2e-29
Identities = 67/222 (30%), Positives = 120/222 (54%), Gaps = 11/222 (4%)
Query: 7 TKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPV 66
++T +++ + H S V+S + +L+ TG DD V LW I K I + +T V
Sbjct: 138 SETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQV 196
Query: 67 ESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQD 126
+V N + I++G I+VWDL K+ T+ GH ++ L G ++ S + D
Sbjct: 197 LAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMD 256
Query: 127 TNIKLWDIR----RKGCVFRYRGH-----SQAVRCLRFSPDGKWLASAADDHTVKLWDLT 177
+++WD+R ++ CV ++G+ +RC +SPDG +A+ + D V +WD T
Sbjct: 257 NTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRC-SWSPDGSKIAAGSADRFVYVWDTT 315
Query: 178 AGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219
+ +++ + PGH G +N V FHP+E ++ S SSD+ + +++
Sbjct: 316 SRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357
Score = 105 bits (261), Expect = 2e-22
Identities = 65/234 (27%), Positives = 116/234 (49%), Gaps = 11/234 (4%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVR-LNTPEELIVAGSQSGSIRVWD 91
G +L + D V +W + L GHTS V S +L+ GS G++++WD
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180
Query: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
+ ++T + + ++ F+ + + SG D +IK+WD+R+ + RGH+ +V
Sbjct: 181 IRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239
Query: 152 CLRFSPDGKWLASAADDHTVKLWDLTA----GKMMSEFPG--HTGPVNVVE--FHPNEYL 203
L S +G +L S A D+TV++WD+ + + F G H N++ + P+
Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSK 299
Query: 204 LASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVY 257
+A+GS+DR + WD +++ + G G + V F+PD + S D R+Y
Sbjct: 300 IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDK-RLY 352
Score = 97.4 bits (241), Expect = 4e-20
Identities = 66/239 (27%), Positives = 111/239 (46%), Gaps = 12/239 (5%)
Query: 32 SGRLLATGGDDCRVNLWSI-NKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90
+G LA+ G D + LW++ + +L GH+ V + NT ++ + S ++ VW
Sbjct: 77 NGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVW 136
Query: 91 DLEAAKILRTLMGHKANICSLDFHPYG-EFVASGSQDTNIKLWDIRRKGCVFRYRGHSQA 149
D E + ++ L GH + + S G + V +GS D +KLWDIR+K + ++ Q
Sbjct: 137 DSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTYQ- 195
Query: 150 VRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSS 209
V + F+ + S D+ +K+WDL K+ GH V + L S +
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAM 255
Query: 210 DRTIRFWDLEKFQVVS-CIEGEPGPVRS-------VLFNPDGCCLYSGCQDSLRVYGWE 260
D T+R WD+ F C++ G V + ++PDG + +G D VY W+
Sbjct: 256 DNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRF-VYVWD 313
Score = 80.9 bits (198), Expect = 3e-15
Identities = 58/175 (33%), Positives = 83/175 (47%), Gaps = 9/175 (5%)
Query: 83 QSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFR 142
Q+G R L+A +L L GH+ + FHP G +AS D I LW++ G
Sbjct: 46 QAGPPRCSSLQAPIML--LSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVY--GDCDN 101
Query: 143 Y---RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVN-VVEFH 198
Y +GHS AV L ++ DG L SA+ D TV +WD G+ + GHT VN
Sbjct: 102 YATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR 161
Query: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
L+ +GS D T++ WD+ K + + V +V FN + SG D+
Sbjct: 162 RGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDN 215
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 127 bits (319), Expect = 3e-29
Identities = 64/195 (32%), Positives = 102/195 (52%), Gaps = 2/195 (1%)
Query: 24 SSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQ 83
S+ L +SG L + +D + W + + GH PV + ++ +GS
Sbjct: 347 STRFLADSSGLLSCS--EDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSH 404
Query: 84 SGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRY 143
+ R+W + LR GH A++ + FHP ++A+GS D ++LW ++ V +
Sbjct: 405 DRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLF 464
Query: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYL 203
GH V L FSP+GK+LASA +D +KLWDL +G + E GHT + + F P+ L
Sbjct: 465 TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGL 524
Query: 204 LASGSSDRTIRFWDL 218
+AS S D ++R WD+
Sbjct: 525 IASASMDNSVRVWDI 539
Score = 124 bits (311), Expect = 3e-28
Identities = 69/200 (34%), Positives = 98/200 (49%), Gaps = 1/200 (0%)
Query: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE 118
L GH PV S R +++ S+ SIR WDL + GH + LD PY
Sbjct: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
Query: 119 FVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178
+ ASGS D +LW R + Y GH V C++F P+ +LA+ + D TV+LW
Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
Query: 179 GKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVL 238
G + F GH GPV + F PN LAS D+ ++ WDL + + G + S+
Sbjct: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLT 517
Query: 239 FNPDGCCLYSGCQD-SLRVY 257
F+PD + S D S+RV+
Sbjct: 518 FSPDSGLIASASMDNSVRVW 537
Score = 103 bits (257), Expect = 5e-22
Identities = 67/227 (29%), Positives = 106/227 (46%), Gaps = 11/227 (4%)
Query: 34 RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLE 93
+LLA G D+ + LWS+ L V+ R++ +++ D
Sbjct: 281 KLLAAGFDNSCIKLWSLRSKK----LKSEPHQVDVSRIHLACDILEEEDDE------DDN 330
Query: 94 AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCL 153
A ++ L GH + S F + S S+D +I+ WD+ Y+GH+ V L
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390
Query: 154 RFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTI 213
SP + AS + D T +LW + + GH V+ V+FHPN LA+GS+D+T+
Sbjct: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTV 450
Query: 214 RFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260
R W ++ V G GPV S+ F+P+G L S +D R+ W+
Sbjct: 451 RLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ-RLKLWD 496
Score = 80.5 bits (197), Expect = 5e-15
Identities = 37/104 (35%), Positives = 56/104 (53%)
Query: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
LATG D V LWS + N + TGH PV S+ + + + + + +++WDL +
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
Query: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGC 139
+ + L GH NI SL F P +AS S D ++++WDIR C
Sbjct: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
Score = 54.3 bits (129), Expect = 3e-07
Identities = 39/146 (26%), Positives = 53/146 (36%), Gaps = 32/146 (21%)
Query: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSE-------------- 184
C + + Q + SPD K LA+ D+ +KLW L + K+ SE
Sbjct: 260 CFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD 319
Query: 185 ------------------FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSC 226
GH GPV F + L S S D +IR+WDL F
Sbjct: 320 ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379
Query: 227 IEGEPGPVRSVLFNPDGCCLYSGCQD 252
+G PV + +P SG D
Sbjct: 380 YQGHAYPVWDLDISPYSLYFASGSHD 405
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 126 bits (316), Expect = 7e-29
Identities = 68/251 (27%), Positives = 124/251 (49%), Gaps = 21/251 (8%)
Query: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
++ + +D + +W + +L GHT V+ + + +L+ + S +I++WD +
Sbjct: 122 VMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQG 181
Query: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
+ +RT+ GH N+ S+ P G+ + S S+D IK+W+++ CV + GH + VR +R
Sbjct: 182 FECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVR 241
Query: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY------------ 202
+ DG +AS ++D TV++W + + +E H V + + P
Sbjct: 242 PNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSET 301
Query: 203 --------LLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-S 253
L SGS D+TI+ WD+ + + G VR VLF+ G + S D +
Sbjct: 302 KKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKT 361
Query: 254 LRVYGWEPERC 264
LRV+ ++ +RC
Sbjct: 362 LRVWDYKNKRC 372
Score = 113 bits (282), Expect = 6e-25
Identities = 64/192 (33%), Positives = 98/192 (51%), Gaps = 10/192 (5%)
Query: 50 INKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANIC 109
I +P +L+GH SPV V + ++V+ S+ +I+VWD E RTL GH ++
Sbjct: 95 IPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQ 154
Query: 110 SLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDH 169
+ F G+ +AS S D IKLWD + C+ GH V + P+G + SA+ D
Sbjct: 155 DISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDK 214
Query: 170 TVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDL----------E 219
T+K+W++ G + F GH V +V + + L+AS S+D+T+R W + E
Sbjct: 215 TIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELRE 274
Query: 220 KFQVVSCIEGEP 231
VV CI P
Sbjct: 275 HEHVVECISWAP 286
Score = 110 bits (275), Expect = 4e-24
Identities = 65/249 (26%), Positives = 114/249 (45%), Gaps = 21/249 (8%)
Query: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
SG+LLA+ D + LW CI ++ GH V SV + + IV+ S+ +I++W+
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Query: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
++ ++T GH+ + + + G +AS S D +++W + K C R H V
Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
Query: 152 CLRFSPD--------------------GKWLASAADDHTVKLWDLTAGKMMSEFPGHTGP 191
C+ ++P+ G +L S + D T+K+WD++ G + GH
Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNW 340
Query: 192 VNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQ 251
V V FH + S + D+T+R WD + + + + V S+ F+ + +G
Sbjct: 341 VRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSV 400
Query: 252 DSLRVYGWE 260
D V WE
Sbjct: 401 DQ-TVKVWE 408
Score = 91.7 bits (226), Expect = 2e-18
Identities = 52/159 (32%), Positives = 77/159 (48%), Gaps = 1/159 (0%)
Query: 101 LMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGK 160
L GH++ + + FHP + S S+D IK+WD +GH+ +V+ + F GK
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGK 163
Query: 161 WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
LAS + D T+KLWD + + GH V+ V PN + S S D+TI+ W+++
Sbjct: 164 LLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQT 223
Query: 221 FQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGW 259
V G VR V N DG L + C + V W
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDG-TLIASCSNDQTVRVW 261
Score = 77.0 bits (188), Expect = 5e-14
Identities = 42/170 (24%), Positives = 75/170 (44%), Gaps = 20/170 (11%)
Query: 26 LVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESV---------------- 69
+V G L+A+ +D V +W + C L H VE +
Sbjct: 239 MVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATG 298
Query: 70 ----RLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
+ P +++GS+ +I++WD+ L TL+GH + + FH G+F+ S +
Sbjct: 299 SETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCAD 358
Query: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWD 175
D +++WD + K C+ H V L F ++ + + D TVK+W+
Sbjct: 359 DKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 74.7 bits (182), Expect = 2e-13
Identities = 32/103 (31%), Positives = 59/103 (57%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
G L +G D + +W ++ C+M+L GH + V V ++ + I++ + ++RVWD
Sbjct: 308 GPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDY 367
Query: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
+ + ++TL H+ + SLDFH +V +GS D +K+W+ R
Sbjct: 368 KNKRCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410
Score = 38.9 bits (89), Expect = 0.015
Identities = 21/83 (25%), Positives = 38/83 (45%), Gaps = 1/83 (1%)
Query: 9 TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVES 68
T L +V H + V VL + G+ + + DD + +W C+ +L H V S
Sbjct: 327 TGMCLMTLVGHDNWVRG-VLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTS 385
Query: 69 VRLNTPEELIVAGSQSGSIRVWD 91
+ + +V GS +++VW+
Sbjct: 386 LDFHKTAPYVVTGSVDQTVKVWE 408
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 123 bits (308), Expect = 6e-28
Identities = 65/217 (29%), Positives = 109/217 (50%), Gaps = 4/217 (1%)
Query: 52 KPNCIMSLT--GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANIC 109
KPN + T GHT V SV+ + E + + S I++W K +T+ GHK I
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 110 SLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDH 169
+ + + S S D +K+WD+ C+ +GHS V C F+P + S + D
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 170 TVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVV-SCIE 228
+V++WD+ GK + P H+ PV+ V F+ + L+ S S D R WD Q + + I+
Sbjct: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 229 GEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
+ PV V F+P+G + + D +L+++ + +C
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248
Score = 121 bits (303), Expect = 2e-27
Identities = 69/261 (26%), Positives = 124/261 (47%), Gaps = 7/261 (2%)
Query: 3 TPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGH 62
TPV A K + H VSS+ +G LA+ D + +W +++GH
Sbjct: 29 TPVKPNYALKFT-LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGH 86
Query: 63 TSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVAS 122
+ V ++ L+V+ S ++++WD+ + K L+TL GH + +F+P + S
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 123 GSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMM 182
GS D ++++WD++ C+ HS V + F+ DG + S++ D ++WD +G+ +
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 183 SE-FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN- 240
PV+ V+F PN + + + D T++ WD K + + G + N
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 241 --PDGCCLYSGCQDSLRVYGW 259
G + SG +D+L VY W
Sbjct: 267 SVTGGKWIVSGSEDNL-VYIW 286
Score = 118 bits (296), Expect = 2e-26
Identities = 59/188 (31%), Positives = 100/188 (53%), Gaps = 6/188 (3%)
Query: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
L+ +G D V +W + C+ +L H+ PV +V N LIV+ S G R+WD +
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202
Query: 95 AKILRTLMGH-KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCL 153
+ L+TL+ + + F P G+++ + + D +KLWD + C+ Y GH C+
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262
Query: 154 --RFS-PDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS-- 208
FS GKW+ S ++D+ V +W+L +++ + GHT V HP E ++AS +
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALE 322
Query: 209 SDRTIRFW 216
+D+TI+ W
Sbjct: 323 NDKTIKLW 330
Score = 117 bits (294), Expect = 3e-26
Identities = 65/230 (28%), Positives = 113/230 (49%), Gaps = 5/230 (2%)
Query: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75
I H +S V + LL + DD + +W ++ C+ +L GH++ V N
Sbjct: 83 ISGHKLGISD-VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141
Query: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
LIV+GS S+R+WD++ K L+TL H + ++ F+ G + S S D ++WD
Sbjct: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 136 RKGCVFRY-RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV 194
C+ + V ++FSP+GK++ +A D+T+KLWD + GK + + GH
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
Query: 195 VEFH---PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241
+ + + SGS D + W+L+ ++V ++G V S +P
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Score = 33.5 bits (75), Expect = 0.64
Identities = 15/60 (25%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGS--QSGSIRVW 90
G+ + +G +D V +W++ + L GHT V S + E +I + + +I++W
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 123 bits (308), Expect = 6e-28
Identities = 65/217 (29%), Positives = 109/217 (50%), Gaps = 4/217 (1%)
Query: 52 KPNCIMSLT--GHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANIC 109
KPN + T GHT V SV+ + E + + S I++W K +T+ GHK I
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGIS 91
Query: 110 SLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDH 169
+ + + S S D +K+WD+ C+ +GHS V C F+P + S + D
Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDE 151
Query: 170 TVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVV-SCIE 228
+V++WD+ GK + P H+ PV+ V F+ + L+ S S D R WD Q + + I+
Sbjct: 152 SVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLID 211
Query: 229 GEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
+ PV V F+P+G + + D +L+++ + +C
Sbjct: 212 DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKC 248
Score = 121 bits (303), Expect = 2e-27
Identities = 69/261 (26%), Positives = 124/261 (47%), Gaps = 7/261 (2%)
Query: 3 TPVVTKTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGH 62
TPV A K + H VSS+ +G LA+ D + +W +++GH
Sbjct: 29 TPVKPNYALKFT-LAGHTKAVSSVKFSP-NGEWLASSSADKLIKIWGAYDGKFEKTISGH 86
Query: 63 TSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVAS 122
+ V ++ L+V+ S ++++WD+ + K L+TL GH + +F+P + S
Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS 146
Query: 123 GSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMM 182
GS D ++++WD++ C+ HS V + F+ DG + S++ D ++WD +G+ +
Sbjct: 147 GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCL 206
Query: 183 SE-FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN- 240
PV+ V+F PN + + + D T++ WD K + + G + N
Sbjct: 207 KTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANF 266
Query: 241 --PDGCCLYSGCQDSLRVYGW 259
G + SG +D+L VY W
Sbjct: 267 SVTGGKWIVSGSEDNL-VYIW 286
Score = 118 bits (296), Expect = 2e-26
Identities = 59/188 (31%), Positives = 100/188 (53%), Gaps = 6/188 (3%)
Query: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
L+ +G D V +W + C+ +L H+ PV +V N LIV+ S G R+WD +
Sbjct: 143 LIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202
Query: 95 AKILRTLMGH-KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCL 153
+ L+TL+ + + F P G+++ + + D +KLWD + C+ Y GH C+
Sbjct: 203 GQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCI 262
Query: 154 --RFS-PDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS-- 208
FS GKW+ S ++D+ V +W+L +++ + GHT V HP E ++AS +
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALE 322
Query: 209 SDRTIRFW 216
+D+TI+ W
Sbjct: 323 NDKTIKLW 330
Score = 117 bits (294), Expect = 3e-26
Identities = 65/230 (28%), Positives = 113/230 (49%), Gaps = 5/230 (2%)
Query: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75
I H +S V + LL + DD + +W ++ C+ +L GH++ V N
Sbjct: 83 ISGHKLGISD-VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141
Query: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
LIV+GS S+R+WD++ K L+TL H + ++ F+ G + S S D ++WD
Sbjct: 142 NLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTA 201
Query: 136 RKGCVFRY-RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV 194
C+ + V ++FSP+GK++ +A D+T+KLWD + GK + + GH
Sbjct: 202 SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYC 261
Query: 195 VEFH---PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241
+ + + SGS D + W+L+ ++V ++G V S +P
Sbjct: 262 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHP 311
Score = 33.5 bits (75), Expect = 0.64
Identities = 15/60 (25%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGS--QSGSIRVW 90
G+ + +G +D V +W++ + L GHT V S + E +I + + +I++W
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 123 bits (308), Expect = 6e-28
Identities = 62/188 (32%), Positives = 102/188 (54%), Gaps = 6/188 (3%)
Query: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
L+ +G D V +W + C+ +L+ H+ PV +V N LIV+GS G R+WD +
Sbjct: 139 LIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAAS 198
Query: 95 AKILRTLMGH-KANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCL 153
+ L+TL+ + + F P G+++ + + D +KLWD R C+ Y GH C+
Sbjct: 199 GQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCI 258
Query: 154 --RFS-PDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS-- 208
FS GKW+ S ++D+ V +W+L +++ + GHT V HP E L+AS +
Sbjct: 259 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE 318
Query: 209 SDRTIRFW 216
+D+TI+ W
Sbjct: 319 NDKTIKLW 326
Score = 119 bits (299), Expect = 7e-27
Identities = 65/209 (31%), Positives = 105/209 (50%), Gaps = 2/209 (0%)
Query: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117
+L GHT V SV+ + E + + S I +W K +TL GH I + +
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 118 EFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLT 177
+ S S D +KLWD+R C+ +GHS V C F+P + S + D TVK+W++
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 178 AGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVV-SCIEGEPGPVRS 236
GK + H+ PV+ V F+ + L+ SGS D R WD Q + + ++ + PV
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215
Query: 237 VLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
V F+P+G + + D +L+++ + RC
Sbjct: 216 VKFSPNGKYILTATLDNTLKLWDYSRGRC 244
Score = 118 bits (295), Expect = 2e-26
Identities = 62/230 (26%), Positives = 115/230 (50%), Gaps = 5/230 (2%)
Query: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75
+ H +S + S RL++ DD + LW + C+ +L GH++ V N P
Sbjct: 79 LYGHNLEISDVAWSSDSSRLVSAS-DDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137
Query: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
LI++GS ++++W+++ K L+TL H + ++ F+ G + SGS D ++WD
Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAA 197
Query: 136 RKGCVFRY-RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV 194
C+ + V ++FSP+GK++ +A D+T+KLWD + G+ + + GH
Sbjct: 198 SGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYC 257
Query: 195 VEFH---PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241
+ + + SGS D + W+L+ ++V ++G V S +P
Sbjct: 258 IFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHP 307
Score = 111 bits (277), Expect = 2e-24
Identities = 63/248 (25%), Positives = 115/248 (46%), Gaps = 6/248 (2%)
Query: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75
+V H VSS+ +G LA+ D + +W +L GH + V ++
Sbjct: 37 LVGHTEAVSSVKFSP-NGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
+V+ S ++++WD+ + K L+TL GH + +F+P + SGS D +K+W+++
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVK 155
Query: 136 RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF-PGHTGPVNV 194
C+ HS V + F+ G + S + D ++WD +G+ + PV+
Sbjct: 156 TGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215
Query: 195 VEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFN---PDGCCLYSGCQ 251
V+F PN + + + D T++ WD + + + G + N G + SG +
Sbjct: 216 VKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSE 275
Query: 252 DSLRVYGW 259
D+L VY W
Sbjct: 276 DNL-VYIW 282
Score = 34.3 bits (77), Expect = 0.37
Identities = 16/60 (26%), Positives = 30/60 (50%), Gaps = 2/60 (3%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGS--QSGSIRVW 90
G+ + +G +D V +W++ + L GHT V S + E LI + + +I++W
Sbjct: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 121 bits (304), Expect = 2e-27
Identities = 66/217 (30%), Positives = 117/217 (53%), Gaps = 11/217 (5%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
L+ +V H V S + ++ +G D + +W+ CI +L GHTS V + L+
Sbjct: 296 LRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 352
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
E+ +V+GS+ ++RVWD+E + L LMGH A + + + G V SG+ D +K+W
Sbjct: 353 --EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 408
Query: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPV 192
D + C+ +GH+ V L+F DG + S + D ++++WD+ G + GH
Sbjct: 409 DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT 466
Query: 193 NVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEG 229
+ +E N +L SG++D T++ WD++ Q + ++G
Sbjct: 467 SGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQG 501
Score = 116 bits (291), Expect = 6e-26
Identities = 63/197 (31%), Positives = 105/197 (53%), Gaps = 8/197 (4%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
G + +G DD + +WS C+ +L GHT V S ++ + +I++GS +++VW+
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNA 330
Query: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
E + + TL GH + + + H + V SGS+D +++WDI C+ GH AVRC
Sbjct: 331 ETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 388
Query: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
+++ DG+ + S A D VK+WD + GHT V ++F + + SGS D +
Sbjct: 389 VQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTS 444
Query: 213 IRFWDLEKFQVVSCIEG 229
IR WD+E + + G
Sbjct: 445 IRVWDVETGNCIHTLTG 461
Score = 102 bits (254), Expect = 1e-21
Identities = 61/210 (29%), Positives = 99/210 (47%), Gaps = 14/210 (6%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
+ + H S V + L + + + +G D + +W I C+ L GH + V V+ +
Sbjct: 336 IHTLYGHTSTVRCMHLHE---KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 392
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
+V+G+ ++VWD E L TL GH + SL F G V SGS DT+I++W
Sbjct: 393 GRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVW 448
Query: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG---HT 189
D+ C+ GH + + L S D TVK+WD+ G+ + G H
Sbjct: 449 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 506
Query: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219
V ++F+ N + + S D T++ WDL+
Sbjct: 507 SAVTCLQFNKN--FVITSSDDGTVKLWDLK 534
Score = 97.8 bits (242), Expect = 3e-20
Identities = 64/213 (30%), Positives = 109/213 (51%), Gaps = 17/213 (7%)
Query: 8 KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67
+T L ++ H + V + + GR + +G D V +W C+ +L GHT+ V
Sbjct: 371 ETGQCLHVLMGHVAAVRCV---QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 427
Query: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
S++ + +V+GS SIRVWD+E + TL GH++ ++ + SG+ D+
Sbjct: 428 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADS 483
Query: 128 NIKLWDIRRKGCVFRYRG---HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS- 183
+K+WDI+ C+ +G H AV CL+F+ + ++ +++DD TVKLWDL G+ +
Sbjct: 484 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRN 541
Query: 184 ----EFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
E G G V + + + A GS + T
Sbjct: 542 LVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 574
Score = 95.9 bits (237), Expect = 1e-19
Identities = 57/188 (30%), Positives = 91/188 (48%), Gaps = 9/188 (4%)
Query: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
IV+GS +++VW K LRTL+GH + S + SGS D +K+W+
Sbjct: 276 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD--NIIISGSTDRTLKVWNAETG 333
Query: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
C+ GH+ VRC+ K + S + D T+++WD+ G+ + GH V V++
Sbjct: 334 ECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY 391
Query: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRV 256
+ SG+ D ++ WD E + ++G V S+ F DG + SG D S+RV
Sbjct: 392 DGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRV 447
Query: 257 YGWEPERC 264
+ E C
Sbjct: 448 WDVETGNC 455
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/174 (30%), Positives = 81/174 (46%), Gaps = 10/174 (5%)
Query: 90 WDLEAAKILRTLMGHKANICS-LDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQ 148
W K + L GH ++ + L F G + SGS D +K+W C+ GH+
Sbjct: 247 WRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG 304
Query: 149 AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS 208
V + + + S + D T+K+W+ G+ + GHT V + H E + SGS
Sbjct: 305 GVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGS 360
Query: 209 SDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPE 262
D T+R WD+E Q + + G VR V + DG + SG D + V W+PE
Sbjct: 361 RDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFM-VKVWDPE 411
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 121 bits (304), Expect = 2e-27
Identities = 66/217 (30%), Positives = 117/217 (53%), Gaps = 11/217 (5%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
L+ +V H V S + ++ +G D + +W+ CI +L GHTS V + L+
Sbjct: 414 LRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 470
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
E+ +V+GS+ ++RVWD+E + L LMGH A + + + G V SG+ D +K+W
Sbjct: 471 --EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 526
Query: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPV 192
D + C+ +GH+ V L+F DG + S + D ++++WD+ G + GH
Sbjct: 527 DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT 584
Query: 193 NVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEG 229
+ +E N +L SG++D T++ WD++ Q + ++G
Sbjct: 585 SGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQG 619
Score = 116 bits (291), Expect = 6e-26
Identities = 63/197 (31%), Positives = 105/197 (53%), Gaps = 8/197 (4%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
G + +G DD + +WS C+ +L GHT V S ++ + +I++GS +++VW+
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNA 448
Query: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
E + + TL GH + + + H + V SGS+D +++WDI C+ GH AVRC
Sbjct: 449 ETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 506
Query: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
+++ DG+ + S A D VK+WD + GHT V ++F + + SGS D +
Sbjct: 507 VQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTS 562
Query: 213 IRFWDLEKFQVVSCIEG 229
IR WD+E + + G
Sbjct: 563 IRVWDVETGNCIHTLTG 579
Score = 102 bits (254), Expect = 1e-21
Identities = 61/210 (29%), Positives = 99/210 (47%), Gaps = 14/210 (6%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
+ + H S V + L + + + +G D + +W I C+ L GH + V V+ +
Sbjct: 454 IHTLYGHTSTVRCMHLHE---KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 510
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
+V+G+ ++VWD E L TL GH + SL F G V SGS DT+I++W
Sbjct: 511 GRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVW 566
Query: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG---HT 189
D+ C+ GH + + L S D TVK+WD+ G+ + G H
Sbjct: 567 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 624
Query: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219
V ++F+ N + + S D T++ WDL+
Sbjct: 625 SAVTCLQFNKN--FVITSSDDGTVKLWDLK 652
Score = 97.8 bits (242), Expect = 3e-20
Identities = 64/213 (30%), Positives = 109/213 (51%), Gaps = 17/213 (7%)
Query: 8 KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67
+T L ++ H + V + + GR + +G D V +W C+ +L GHT+ V
Sbjct: 489 ETGQCLHVLMGHVAAVRCV---QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 545
Query: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
S++ + +V+GS SIRVWD+E + TL GH++ ++ + SG+ D+
Sbjct: 546 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADS 601
Query: 128 NIKLWDIRRKGCVFRYRG---HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS- 183
+K+WDI+ C+ +G H AV CL+F+ + ++ +++DD TVKLWDL G+ +
Sbjct: 602 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRN 659
Query: 184 ----EFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
E G G V + + + A GS + T
Sbjct: 660 LVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 692
Score = 95.9 bits (237), Expect = 1e-19
Identities = 57/188 (30%), Positives = 91/188 (48%), Gaps = 9/188 (4%)
Query: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
IV+GS +++VW K LRTL+GH + S + SGS D +K+W+
Sbjct: 394 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD--NIIISGSTDRTLKVWNAETG 451
Query: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
C+ GH+ VRC+ K + S + D T+++WD+ G+ + GH V V++
Sbjct: 452 ECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY 509
Query: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRV 256
+ SG+ D ++ WD E + ++G V S+ F DG + SG D S+RV
Sbjct: 510 DGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRV 565
Query: 257 YGWEPERC 264
+ E C
Sbjct: 566 WDVETGNC 573
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/174 (30%), Positives = 81/174 (46%), Gaps = 10/174 (5%)
Query: 90 WDLEAAKILRTLMGHKANICS-LDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQ 148
W K + L GH ++ + L F G + SGS D +K+W C+ GH+
Sbjct: 365 WRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG 422
Query: 149 AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS 208
V + + + S + D T+K+W+ G+ + GHT V + H E + SGS
Sbjct: 423 GVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGS 478
Query: 209 SDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPE 262
D T+R WD+E Q + + G VR V + DG + SG D + V W+PE
Sbjct: 479 RDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFM-VKVWDPE 529
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 121 bits (304), Expect = 2e-27
Identities = 66/217 (30%), Positives = 117/217 (53%), Gaps = 11/217 (5%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
L+ +V H V S + ++ +G D + +W+ CI +L GHTS V + L+
Sbjct: 334 LRTLVGHTGGVWS---SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH 390
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
E+ +V+GS+ ++RVWD+E + L LMGH A + + + G V SG+ D +K+W
Sbjct: 391 --EKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD--GRRVVSGAYDFMVKVW 446
Query: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPV 192
D + C+ +GH+ V L+F DG + S + D ++++WD+ G + GH
Sbjct: 447 DPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLT 504
Query: 193 NVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEG 229
+ +E N +L SG++D T++ WD++ Q + ++G
Sbjct: 505 SGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQG 539
Score = 116 bits (291), Expect = 6e-26
Identities = 63/197 (31%), Positives = 105/197 (53%), Gaps = 8/197 (4%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
G + +G DD + +WS C+ +L GHT V S ++ + +I++GS +++VW+
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKVWNA 368
Query: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
E + + TL GH + + + H + V SGS+D +++WDI C+ GH AVRC
Sbjct: 369 ETGECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRC 426
Query: 153 LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
+++ DG+ + S A D VK+WD + GHT V ++F + + SGS D +
Sbjct: 427 VQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTS 482
Query: 213 IRFWDLEKFQVVSCIEG 229
IR WD+E + + G
Sbjct: 483 IRVWDVETGNCIHTLTG 499
Score = 102 bits (254), Expect = 1e-21
Identities = 61/210 (29%), Positives = 99/210 (47%), Gaps = 14/210 (6%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
+ + H S V + L + + + +G D + +W I C+ L GH + V V+ +
Sbjct: 374 IHTLYGHTSTVRCMHLHE---KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYD 430
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
+V+G+ ++VWD E L TL GH + SL F G V SGS DT+I++W
Sbjct: 431 GRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFD--GIHVVSGSLDTSIRVW 486
Query: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPG---HT 189
D+ C+ GH + + L S D TVK+WD+ G+ + G H
Sbjct: 487 DVETGNCIHTLTGHQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 544
Query: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLE 219
V ++F+ N + + S D T++ WDL+
Sbjct: 545 SAVTCLQFNKN--FVITSSDDGTVKLWDLK 572
Score = 97.8 bits (242), Expect = 3e-20
Identities = 64/213 (30%), Positives = 109/213 (51%), Gaps = 17/213 (7%)
Query: 8 KTAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVE 67
+T L ++ H + V + + GR + +G D V +W C+ +L GHT+ V
Sbjct: 409 ETGQCLHVLMGHVAAVRCV---QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVY 465
Query: 68 SVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
S++ + +V+GS SIRVWD+E + TL GH++ ++ + SG+ D+
Sbjct: 466 SLQFDGIH--VVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELK--DNILVSGNADS 521
Query: 128 NIKLWDIRRKGCVFRYRG---HSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS- 183
+K+WDI+ C+ +G H AV CL+F+ + ++ +++DD TVKLWDL G+ +
Sbjct: 522 TVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKN--FVITSSDDGTVKLWDLKTGEFIRN 579
Query: 184 ----EFPGHTGPVNVVEFHPNEYLLASGSSDRT 212
E G G V + + + A GS + T
Sbjct: 580 LVTLESGGSGGVVWRIRASNTKLVCAVGSRNGT 612
Score = 95.9 bits (237), Expect = 1e-19
Identities = 57/188 (30%), Positives = 91/188 (48%), Gaps = 9/188 (4%)
Query: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
IV+GS +++VW K LRTL+GH + S + SGS D +K+W+
Sbjct: 314 IVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRD--NIIISGSTDRTLKVWNAETG 371
Query: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEF 197
C+ GH+ VRC+ K + S + D T+++WD+ G+ + GH V V++
Sbjct: 372 ECIHTLYGHTSTVRCMHLHE--KRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQY 429
Query: 198 HPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRV 256
+ SG+ D ++ WD E + ++G V S+ F DG + SG D S+RV
Sbjct: 430 DGRR--VVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRV 485
Query: 257 YGWEPERC 264
+ E C
Sbjct: 486 WDVETGNC 493
Score = 74.3 bits (181), Expect = 3e-13
Identities = 53/174 (30%), Positives = 81/174 (46%), Gaps = 10/174 (5%)
Query: 90 WDLEAAKILRTLMGHKANICS-LDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQ 148
W K + L GH ++ + L F G + SGS D +K+W C+ GH+
Sbjct: 285 WRRGELKSPKVLKGHDDHVITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTG 342
Query: 149 AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGS 208
V + + + S + D T+K+W+ G+ + GHT V + H E + SGS
Sbjct: 343 GVWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLH--EKRVVSGS 398
Query: 209 SDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWEPE 262
D T+R WD+E Q + + G VR V + DG + SG D + V W+PE
Sbjct: 399 RDATLRVWDIETGQCLHVLMGHVAAVRCVQY--DGRRVVSGAYDFM-VKVWDPE 449
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 119 bits (297), Expect = 1e-26
Identities = 88/303 (29%), Positives = 138/303 (45%), Gaps = 16/303 (5%)
Query: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
H V+S G++L TG +D V W + L GHT PV+ R + L
Sbjct: 20 HGGEVNSSAFSP-DGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLF 78
Query: 79 VAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKG 138
+ S ++R+WD+ AK LR L GH+ ++ ++ F P +ASG D + LWD++
Sbjct: 79 ASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQ 138
Query: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL---TAGKMMSEFPGHTGPVNVV 195
+ GH +++ FSP LA+ + D TV +WDL T GH+ ++ +
Sbjct: 139 MLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCL 198
Query: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS-GCQDSL 254
+ + LLASGS D+TI W ++ ++G V+S+ F+PD L S G +
Sbjct: 199 CYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMV 257
Query: 255 RVYGWEPERCFDVVLVNWGKVADLAICNDQLIGVAFSQSNVSSYVVDLTR--VTRTGTVA 312
+V+ +C + + A D I V S D TR ++RT
Sbjct: 258 KVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILV--------SGAADQTRRQISRTSKSP 309
Query: 313 RDP 315
RDP
Sbjct: 310 RDP 312
Score = 46.2 bits (108), Expect = 9e-05
Identities = 26/85 (30%), Positives = 42/85 (49%), Gaps = 1/85 (1%)
Query: 185 FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGC 244
F H G VN F P+ +L +GS D + W+ Q++ + G GPV+ F+PDG
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
Query: 245 CLYS-GCQDSLRVYGWEPERCFDVV 268
S C ++R++ +C V+
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVL 101
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 116 bits (290), Expect = 7e-26
Identities = 63/238 (26%), Positives = 117/238 (49%), Gaps = 3/238 (1%)
Query: 18 AHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEEL 77
A + +L L + + TGG D V ++ + + +L GHT V SV + ++L
Sbjct: 219 ASIPGILALDLCPSDTNKILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDL 278
Query: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
+ + S +IR+W + A ++ + H++ + L H G+++ S S D DI+
Sbjct: 279 VFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTG 338
Query: 138 GCVFRYRGHSQ--AVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
+ + + ++ C +F PDG + D +K+WDL ++ FPGH+GP+ +
Sbjct: 339 RVLTKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSI 398
Query: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPG-PVRSVLFNPDGCCLYSGCQD 252
F N Y LA+ + D +++ WDL K + ++ + V+S++F+ G L G D
Sbjct: 399 AFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFEVKSLIFDQSGTYLALGGTD 456
Score = 103 bits (258), Expect = 4e-22
Identities = 54/178 (30%), Positives = 90/178 (50%), Gaps = 2/178 (1%)
Query: 78 IVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
I+ G ++ V+D + +IL TL GH + S+ FHP + V S S D I++W +
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKGHTKKVTSVVFHPSQDLVFSASPDATIRIWSVPNA 296
Query: 138 GCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTG--PVNVV 195
CV R H AV L G +L S++DD D+ G+++++ T +
Sbjct: 297 SCVQVVRAHESAVTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGCSLTCA 356
Query: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDS 253
+FHP+ + +G+ D I+ WDL++ V+ G GP+ S+ F+ +G L + DS
Sbjct: 357 QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDS 414
Score = 92.4 bits (228), Expect = 1e-18
Identities = 63/250 (25%), Positives = 108/250 (43%), Gaps = 46/250 (18%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
L + H V+S+V S L+ + D + +WS+ +C+ + H S V + L+
Sbjct: 257 LATLKGHTKKVTSVVF-HPSQDLVFSASPDATIRIWSVPNASCVQVVRAHESAVTGLSLH 315
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSL---DFHPYGEFVASGSQDTNI 129
+ +++ S D++ ++L T + + + CSL FHP G +G+ D+ I
Sbjct: 316 ATGDYLLSSSDDQYWAFSDIQTGRVL-TKVTDETSGCSLTCAQFHPDGLIFGTGTMDSQI 374
Query: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS------ 183
K+WD++ + V + GHS + + FS +G +LA+AADD +VKLWDL K
Sbjct: 375 KIWDLKERTNVANFPGHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDN 434
Query: 184 -----------------------------------EFPGHTGPVNVVEFHPNEYLLASGS 208
F H+G V F + +AS
Sbjct: 435 NFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEILHFTEHSGLTTGVAFGHHAKFIASTG 494
Query: 209 SDRTIRFWDL 218
DR+++F+ L
Sbjct: 495 MDRSLKFYSL 504
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 115 bits (288), Expect = 1e-25
Identities = 75/269 (27%), Positives = 124/269 (46%), Gaps = 17/269 (6%)
Query: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTS--------PVESVRLNTPEELIVAGSQ 83
+ ++LAT LWS+ N + +L GH + P +V L+ + + + +
Sbjct: 242 NSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNVGAIVFHPKSTVSLDPKDVNLASCAA 301
Query: 84 SGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRY 143
GS+++W L++ + + + GH + + +HP G F+ + D + +LWD+ + +
Sbjct: 302 DGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ 361
Query: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYL 203
GHS V + F DG + D ++WDL G+ + GH + + F PN Y
Sbjct: 362 EGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYH 421
Query: 204 LASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP-DGCCLYSGCQDSLRVY----G 258
+A+GS D T + WDL + + V I V V F P G L +G D+ G
Sbjct: 422 IATGSGDNTCKVWDLRQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPG 481
Query: 259 WEPERCFDVVLVNWGKVADLAICND-QLI 286
W P + + GKV L I +D QLI
Sbjct: 482 WSP---LKTLAGHEGKVMGLDISSDGQLI 507
Score = 107 bits (267), Expect = 3e-23
Identities = 63/206 (30%), Positives = 95/206 (46%), Gaps = 2/206 (0%)
Query: 15 EIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTP 74
+I H V+ V+ SGR L T D LW + I+ GH+ V + +
Sbjct: 318 DIEGHTVRVAR-VMWHPSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQD 376
Query: 75 EELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDI 134
L G RVWDL + + L GH I ++F P G +A+GS D K+WD+
Sbjct: 377 GSLAGTGGLDAFGRVWDLRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDL 436
Query: 135 RRKGCVFRYRGHSQAVRCLRFSP-DGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVN 193
R++ CV+ H V ++F P G +L + A D+T K+W + GH G V
Sbjct: 437 RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVM 496
Query: 194 VVEFHPNEYLLASGSSDRTIRFWDLE 219
++ + L+A+ S DRT + W E
Sbjct: 497 GLDISSDGQLIATCSYDRTFKLWMAE 522
Score = 96.3 bits (238), Expect = 8e-20
Identities = 58/225 (25%), Positives = 102/225 (45%), Gaps = 9/225 (4%)
Query: 49 SINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANI 108
S+ N S G P+ + +++ SG ++W + +L TL GH N+
Sbjct: 217 SLRSLNNFCSQIGDDRPISYCHFSPNSKMLATACWSGLCKLWSVPDCNLLHTLRGHNTNV 276
Query: 109 CSLDFHPYGEF--------VASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGK 160
++ FHP +AS + D ++KLW + V GH+ V + + P G+
Sbjct: 277 GAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMWHPSGR 336
Query: 161 WLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEK 220
+L + D + +LWDL A + + GH+ V + FH + L +G D R WDL
Sbjct: 337 FLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVWDLRT 396
Query: 221 FQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
+ + +EG + + F+P+G + +G D + +V+ RC
Sbjct: 397 GRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRC 441
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 110 bits (276), Expect = 3e-24
Identities = 74/257 (28%), Positives = 122/257 (47%), Gaps = 14/257 (5%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
LQ I + N + + + +G D + +W C+ LTGHT V + L
Sbjct: 230 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQ 287
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
E +IV GS ++RVWD+ ++L TL+ H + L F + + S+D +I +W
Sbjct: 288 YDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 345
Query: 133 DIRRKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
D+ + R GH AV + F D K++ SA+ D T+K+W + + + GH
Sbjct: 346 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 403
Query: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
+ +++ + L+ SGSSD TIR WD+E + +EG VR + F D + SG
Sbjct: 404 RGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSG 459
Query: 250 CQDSLRVYGWEPERCFD 266
D ++ W+ + D
Sbjct: 460 AYDG-KIKVWDLQAALD 475
Score = 95.5 bits (236), Expect = 1e-19
Identities = 69/217 (31%), Positives = 100/217 (46%), Gaps = 23/217 (10%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS---LTGHTSPVESV 69
L ++ H V L + S L+ T D + +W + I L GH + V V
Sbjct: 313 LNTLIHHNEAVLHL---RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 369
Query: 70 RLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNI 129
+ ++ IV+ S +I+VW + +RTL GHK I L + V SGS D I
Sbjct: 370 DFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTI 425
Query: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG---------K 180
+LWDI C+ GH + VRC+RF D K + S A D +K+WDL A
Sbjct: 426 RLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTL 483
Query: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
+ H+G V ++F +E+ + S S D TI WD
Sbjct: 484 CLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 518
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 110 bits (276), Expect = 3e-24
Identities = 74/257 (28%), Positives = 122/257 (47%), Gaps = 14/257 (5%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
LQ I + N + + + +G D + +W C+ LTGHT V + L
Sbjct: 196 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQ 253
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
E +IV GS ++RVWD+ ++L TL+ H + L F + + S+D +I +W
Sbjct: 254 YDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 311
Query: 133 DIRRKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
D+ + R GH AV + F D K++ SA+ D T+K+W + + + GH
Sbjct: 312 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 369
Query: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
+ +++ + L+ SGSSD TIR WD+E + +EG VR + F D + SG
Sbjct: 370 RGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSG 425
Query: 250 CQDSLRVYGWEPERCFD 266
D ++ W+ + D
Sbjct: 426 AYDG-KIKVWDLQAALD 441
Score = 95.5 bits (236), Expect = 1e-19
Identities = 69/217 (31%), Positives = 100/217 (46%), Gaps = 23/217 (10%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS---LTGHTSPVESV 69
L ++ H V L + S L+ T D + +W + I L GH + V V
Sbjct: 279 LNTLIHHNEAVLHL---RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 335
Query: 70 RLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNI 129
+ ++ IV+ S +I+VW + +RTL GHK I L + V SGS D I
Sbjct: 336 DFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTI 391
Query: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG---------K 180
+LWDI C+ GH + VRC+RF D K + S A D +K+WDL A
Sbjct: 392 RLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTL 449
Query: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
+ H+G V ++F +E+ + S S D TI WD
Sbjct: 450 CLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 484
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 110 bits (276), Expect = 3e-24
Identities = 74/257 (28%), Positives = 122/257 (47%), Gaps = 14/257 (5%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
LQ I + N + + + +G D + +W C+ LTGHT V + L
Sbjct: 217 LQRIQCRSENSKGVYCLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSV--LCLQ 274
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
E +IV GS ++RVWD+ ++L TL+ H + L F + + S+D +I +W
Sbjct: 275 YDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFS--NGLMVTCSKDRSIAVW 332
Query: 133 DIRRKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
D+ + R GH AV + F D K++ SA+ D T+K+W + + + GH
Sbjct: 333 DMASATDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHK 390
Query: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
+ +++ + L+ SGSSD TIR WD+E + +EG VR + F D + SG
Sbjct: 391 RGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSG 446
Query: 250 CQDSLRVYGWEPERCFD 266
D ++ W+ + D
Sbjct: 447 AYDG-KIKVWDLQAALD 462
Score = 95.5 bits (236), Expect = 1e-19
Identities = 69/217 (31%), Positives = 100/217 (46%), Gaps = 23/217 (10%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS---LTGHTSPVESV 69
L ++ H V L + S L+ T D + +W + I L GH + V V
Sbjct: 300 LNTLIHHNEAVLHL---RFSNGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVV 356
Query: 70 RLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNI 129
+ ++ IV+ S +I+VW + +RTL GHK I L + V SGS D I
Sbjct: 357 DFD--DKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSSDNTI 412
Query: 130 KLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG---------K 180
+LWDI C+ GH + VRC+RF D K + S A D +K+WDL A
Sbjct: 413 RLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLQAALDPRAPASTL 470
Query: 181 MMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
+ H+G V ++F +E+ + S S D TI WD
Sbjct: 471 CLRTLVEHSGRVFRLQF--DEFQIISSSHDDTILIWD 505
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 108 bits (271), Expect = 1e-23
Identities = 60/212 (28%), Positives = 103/212 (48%), Gaps = 1/212 (0%)
Query: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121
H PV V + ++++V+ + +V L +L T GH + FHP G+ +A
Sbjct: 351 HELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGDKLA 410
Query: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKM 181
+ S DT +KLWD+ + C+ + GHS+AV + G ++AS++ D T K+WD+ + +
Sbjct: 411 TSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSERC 470
Query: 182 MSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNP 241
GHT VN +EF P L + S+D+T+ WD + G + +F+P
Sbjct: 471 RCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSINDAIFDP 530
Query: 242 DGCCLYSGCQDSLRVYGWEPERCFDVVLVNWG 273
G + S C W+ + +V ++ G
Sbjct: 531 RGHMIAS-CDACGVTKLWDFRKLLPIVSIDIG 561
Score = 104 bits (260), Expect = 2e-22
Identities = 62/221 (28%), Positives = 101/221 (45%), Gaps = 1/221 (0%)
Query: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD 91
SG LAT D V LW + K +CI++ GH+ V S ++ + + S + ++WD
Sbjct: 405 SGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWD 464
Query: 92 LEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVR 151
+ + + TL GH ++ S++F P+ + + S D + +WD R C GH ++
Sbjct: 465 VNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQSLYGHMHSIN 524
Query: 152 CLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDR 211
F P G +AS KLWD + P N V F + +LA S +
Sbjct: 525 DAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSGRVLAQASGNG 584
Query: 212 TIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
I DL+ ++ + G +V+F+ DG L+SG D
Sbjct: 585 VIHLLDLKSGEIHKLM-GHENEAHTVVFSHDGEILFSGGSD 624
Score = 102 bits (255), Expect = 9e-22
Identities = 66/240 (27%), Positives = 105/240 (43%), Gaps = 8/240 (3%)
Query: 8 KTAWKLQEIVA-HASNVSSLVLGKASGRLLATGGDDCRVNLWSI-NKPNCIMSLTG--HT 63
K +KL+ I H VS + + L++ G D LW + P C + LTG HT
Sbjct: 339 KFDYKLKNIFRLHELPVSCVSMQPHKDILVSCGED----RLWKVLGLPKCNVLLTGFGHT 394
Query: 64 SPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG 123
+ + + + S ++++WDL + T GH + S +H G FVAS
Sbjct: 395 DWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASS 454
Query: 124 SQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMS 183
S D K+WD+ + C GH+ +V + F P L +++ D T+ +WD G
Sbjct: 455 SLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTGICEQ 514
Query: 184 EFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDG 243
GH +N F P +++AS + + WD K + I+ P P V F+ G
Sbjct: 515 SLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNEVNFDSSG 574
Score = 61.2 bits (147), Expect = 3e-09
Identities = 42/183 (22%), Positives = 63/183 (34%), Gaps = 41/183 (22%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
G +A+ D +W +N C +L GHT V S+ ++ S ++ +WD
Sbjct: 448 GNFVASSSLDKTSKIWDVNSERCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDA 507
Query: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR---------------- 136
++L GH +I F P G +AS KLWD R+
Sbjct: 508 RTGICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVSIDIGPSPGNE 567
Query: 137 -------------------------KGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTV 171
G + + GH + FS DG+ L S D TV
Sbjct: 568 VNFDSSGRVLAQASGNGVIHLLDLKSGEIHKLMGHENEAHTVVFSHDGEILFSGGSDGTV 627
Query: 172 KLW 174
+ W
Sbjct: 628 RTW 630
Score = 50.8 bits (120), Expect = 4e-06
Identities = 35/123 (28%), Positives = 55/123 (44%), Gaps = 1/123 (0%)
Query: 143 YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEY 202
+R H V C+ P L S +D K+ L ++ GHT ++ FHP+
Sbjct: 348 FRLHELPVSCVSMQPHKDILVSCGEDRLWKVLGLPKCNVLLTGFGHTDWLSDCCFHPSGD 407
Query: 203 LLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEP 261
LA+ S D T++ WDL K + EG V S ++ G + S D + +++
Sbjct: 408 KLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNS 467
Query: 262 ERC 264
ERC
Sbjct: 468 ERC 470
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 106 bits (264), Expect = 8e-23
Identities = 72/251 (28%), Positives = 122/251 (48%), Gaps = 14/251 (5%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
LQ I + + + + + +G D + +W N C LTGHT V + L
Sbjct: 257 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQ 314
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
E +I+ GS ++RVWD+ ++L TL+ H + L F+ + + S+D +I +W
Sbjct: 315 YDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVW 372
Query: 133 DIRRKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
D+ + R GH AV + F D K++ SA+ D T+K+W+ + + + GH
Sbjct: 373 DMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 430
Query: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
+ +++ + L+ SGSSD TIR WD+E + +EG VR + F D + SG
Sbjct: 431 RGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSG 486
Query: 250 CQDSLRVYGWE 260
D ++ W+
Sbjct: 487 AYDG-KIKVWD 496
Score = 99.0 bits (245), Expect = 1e-20
Identities = 69/221 (31%), Positives = 103/221 (46%), Gaps = 23/221 (10%)
Query: 9 TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS---LTGHTSP 65
T L ++ H V L + + ++ T D + +W + P I L GH +
Sbjct: 336 TGEMLNTLIHHCEAVLHL---RFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 392
Query: 66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
V V + ++ IV+ S +I+VW+ + +RTL GHK I L + V SGS
Sbjct: 393 VNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSS 448
Query: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG------ 179
D I+LWDI C+ GH + VRC+RF D K + S A D +K+WDL A
Sbjct: 449 DNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAP 506
Query: 180 ---KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
+ H+G V ++F +E+ + S S D TI WD
Sbjct: 507 AGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 545
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 106 bits (264), Expect = 8e-23
Identities = 72/251 (28%), Positives = 122/251 (48%), Gaps = 14/251 (5%)
Query: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
LQ I + + + + + +G D + +W N C LTGHT V + L
Sbjct: 293 LQRIHCRSETSKGVYCLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQ 350
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
E +I+ GS ++RVWD+ ++L TL+ H + L F+ + + S+D +I +W
Sbjct: 351 YDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRFN--NGMMVTCSKDRSIAVW 408
Query: 133 DIRRKGCVFRYR---GHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT 189
D+ + R GH AV + F D K++ SA+ D T+K+W+ + + + GH
Sbjct: 409 DMASPTDITLRRVLVGHRAAVNVVDF--DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHK 466
Query: 190 GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSG 249
+ +++ + L+ SGSSD TIR WD+E + +EG VR + F D + SG
Sbjct: 467 RGIACLQY--RDRLVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSG 522
Query: 250 CQDSLRVYGWE 260
D ++ W+
Sbjct: 523 AYDG-KIKVWD 532
Score = 99.0 bits (245), Expect = 1e-20
Identities = 69/221 (31%), Positives = 103/221 (46%), Gaps = 23/221 (10%)
Query: 9 TAWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMS---LTGHTSP 65
T L ++ H V L + + ++ T D + +W + P I L GH +
Sbjct: 372 TGEMLNTLIHHCEAVLHL---RFNNGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAA 428
Query: 66 VESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQ 125
V V + ++ IV+ S +I+VW+ + +RTL GHK I L + V SGS
Sbjct: 429 VNVVDFD--DKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQYRD--RLVVSGSS 484
Query: 126 DTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAG------ 179
D I+LWDI C+ GH + VRC+RF D K + S A D +K+WDL A
Sbjct: 485 DNTIRLWDIECGACLRVLEGHEELVRCIRF--DNKRIVSGAYDGKIKVWDLVAALDPRAP 542
Query: 180 ---KMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
+ H+G V ++F +E+ + S S D TI WD
Sbjct: 543 AGTLCLRTLVEHSGRVFRLQF--DEFQIVSSSHDDTILIWD 581
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 104 bits (259), Expect = 3e-22
Identities = 72/255 (28%), Positives = 126/255 (49%), Gaps = 10/255 (3%)
Query: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117
+L GH+ V V +++ + ++GS G++R+WDL R +GH ++ S+ F
Sbjct: 58 ALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDN 117
Query: 118 EFVASGSQDTNIKLWDIRRKGCVFRYR--GHSQAVRCLRFSPDGK--WLASAADDHTVKL 173
+ SGS+D IKLW+ C + + HS+ V C+RFSP+ + S D VK+
Sbjct: 118 RQIVSGSRDKTIKLWNTLGV-CKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKV 176
Query: 174 WDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGP 233
W+L K+ + GHTG +N V P+ L ASG D WDL + + + ++G
Sbjct: 177 WNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDI 235
Query: 234 VRSVLFNPDGCCLYSGCQDSLRVYGWEPERCFDVV---LVNWGKVADLAICNDQLIGVAF 290
+ ++ F+P+ L + S++++ E + D + +++ A+ C L A
Sbjct: 236 INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCT-SLAWSAD 294
Query: 291 SQSNVSSYVVDLTRV 305
Q+ + Y +L RV
Sbjct: 295 GQTLFAGYTDNLVRV 309
Score = 92.4 bits (228), Expect = 1e-18
Identities = 69/248 (27%), Positives = 112/248 (45%), Gaps = 15/248 (6%)
Query: 19 HASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELI 78
H+ VS +V+ + G+ +G D + LW + GHT V SV ++ I
Sbjct: 62 HSHFVSDVVIS-SDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQI 120
Query: 79 VAGSQSGSIRVWD-LEAAKILRTLMGHKANICSLDFHPYGE--FVASGSQDTNIKLWDIR 135
V+GS+ +I++W+ L K H + + F P + S D +K+W++
Sbjct: 121 VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLA 180
Query: 136 RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
+ GH+ + + SPDG AS D LWDL GK + G +N +
Sbjct: 181 NCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINAL 239
Query: 196 EFHPNEYLLASGSSDRTIRFWDLE--------KFQVVS-CIEGEPGPVRSVLFNPDGCCL 246
F PN Y L + + +I+ WDLE K +V+S + EP S+ ++ DG L
Sbjct: 240 CFSPNRYWLCAATGP-SIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTL 298
Query: 247 YSGCQDSL 254
++G D+L
Sbjct: 299 FAGYTDNL 306
Score = 84.3 bits (207), Expect = 3e-16
Identities = 58/205 (28%), Positives = 100/205 (48%), Gaps = 11/205 (5%)
Query: 58 SLTGHTSPVESVRLNTPE--ELIVAGSQSGSIRVWDLEAAKI-----LRTLMGHKANICS 110
+L GH V + TP+ ++I++ S+ +I +W L + R L GH +
Sbjct: 10 TLKGHNGWVTQIA-TTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSD 68
Query: 111 LDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHT 170
+ G+F SGS D ++LWD+ R+ GH++ V + FS D + + S + D T
Sbjct: 69 VVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128
Query: 171 VKLWD-LTAGKMMSEFPGHTGPVNVVEFHPNEY--LLASGSSDRTIRFWDLEKFQVVSCI 227
+KLW+ L K + H+ V+ V F PN ++ S D+ ++ W+L ++ +
Sbjct: 129 IKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNH 188
Query: 228 EGEPGPVRSVLFNPDGCCLYSGCQD 252
G G + +V +PDG SG +D
Sbjct: 189 IGHTGYLNTVTVSPDGSLCASGGKD 213
Score = 54.7 bits (130), Expect = 3e-07
Identities = 41/158 (25%), Positives = 75/158 (47%), Gaps = 11/158 (6%)
Query: 31 ASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVW 90
+S ++ + G D V +W++ + GHT + +V ++ L +G + G +W
Sbjct: 160 SSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLW 219
Query: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYR------ 144
DL K L TL G I +L F P ++ + + +IK+WD+ K V +
Sbjct: 220 DLNEGKHLYTLDGGDI-INALCFSPNRYWLCAAT-GPSIKIWDLEGKIIVDELKQEVIST 277
Query: 145 -GHSQAVRC--LRFSPDGKWLASAADDHTVKLWDLTAG 179
++ +C L +S DG+ L + D+ V++W +T G
Sbjct: 278 SSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIG 315
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 103 bits (256), Expect = 7e-22
Identities = 69/237 (29%), Positives = 117/237 (49%), Gaps = 11/237 (4%)
Query: 32 SGRLLATGGDDCRVNLWSI------NKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSG 85
SG +A GG D + +++ + N S+ HT+ + + + I+ S G
Sbjct: 116 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDG 175
Query: 86 SIRVWDLEAAKILRTLMGHKANICSLDFHPY--GEFVASGSQDTNIKLWDIRRKGCVFRY 143
+ +WD+E+ ++L++ GH A++ LD P G SG D +WD+R CV +
Sbjct: 176 TCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAF 235
Query: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT--GPVNVVEFHPNE 201
H + +R+ P G AS +DD T +L+DL A + ++ + + + V+F +
Sbjct: 236 ETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSG 295
Query: 202 YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257
LL +G +D TI WD+ K VS + G V ++ +PDG SG D +LRV+
Sbjct: 296 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 91.7 bits (226), Expect = 2e-18
Identities = 55/211 (26%), Positives = 99/211 (46%), Gaps = 5/211 (2%)
Query: 10 AWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESV 69
A K + + H + +S+ + ++L GD LW + + S GH + V +
Sbjct: 143 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCA-LWDVESGQLLQSFHGHGADVLCL 201
Query: 70 RLNTPE--ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
L E V+G VWD+ + + ++ H+++I S+ ++P G+ ASGS D
Sbjct: 202 DLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDA 261
Query: 128 NIKLWDIR--RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185
+L+D+R R+ ++ + FS G+ L + +D+T+ +WD+ G +S
Sbjct: 262 TCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSIL 321
Query: 186 PGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
GH V+ + P+ SGS D T+R W
Sbjct: 322 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 352
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/215 (23%), Positives = 89/215 (41%), Gaps = 9/215 (4%)
Query: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117
+L GH + V + + IV+ SQ G + VWD + + + + P G
Sbjct: 58 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 117
Query: 118 EFVASGSQDTNIKLWDI---RRKGCVFRYRG---HSQAVRCLRFSPDGKWLASAADDHTV 171
+A G D ++ + + + + + H+ + F+ + +A+ D T
Sbjct: 118 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 177
Query: 172 KLWDLTAGKMMSEFPGHTGPVNVVEFHPNE--YLLASGSSDRTIRFWDLEKFQVVSCIEG 229
LWD+ +G+++ F GH V ++ P+E SG D+ WD+ Q V E
Sbjct: 178 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 237
Query: 230 EPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPER 263
+ SV + P G SG D + R+Y +R
Sbjct: 238 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADR 272
>gi|20336270 guanine nucleotide-binding protein, beta-5 subunit
isoform b [Homo sapiens]
Length = 395
Score = 103 bits (256), Expect = 7e-22
Identities = 69/237 (29%), Positives = 117/237 (49%), Gaps = 11/237 (4%)
Query: 32 SGRLLATGGDDCRVNLWSI------NKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSG 85
SG +A GG D + +++ + N S+ HT+ + + + I+ S G
Sbjct: 158 SGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDG 217
Query: 86 SIRVWDLEAAKILRTLMGHKANICSLDFHPY--GEFVASGSQDTNIKLWDIRRKGCVFRY 143
+ +WD+E+ ++L++ GH A++ LD P G SG D +WD+R CV +
Sbjct: 218 TCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAF 277
Query: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHT--GPVNVVEFHPNE 201
H + +R+ P G AS +DD T +L+DL A + ++ + + + V+F +
Sbjct: 278 ETHESDINSVRYYPSGDAFASGSDDATCRLYDLRADREVAIYSKESIIFGASSVDFSLSG 337
Query: 202 YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVY 257
LL +G +D TI WD+ K VS + G V ++ +PDG SG D +LRV+
Sbjct: 338 RLLFAGYNDYTINVWDVLKGSRVSILFGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 91.7 bits (226), Expect = 2e-18
Identities = 55/211 (26%), Positives = 99/211 (46%), Gaps = 5/211 (2%)
Query: 10 AWKLQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESV 69
A K + + H + +S+ + ++L GD LW + + S GH + V +
Sbjct: 185 AAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTCA-LWDVESGQLLQSFHGHGADVLCL 243
Query: 70 RLNTPE--ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDT 127
L E V+G VWD+ + + ++ H+++I S+ ++P G+ ASGS D
Sbjct: 244 DLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFETHESDINSVRYYPSGDAFASGSDDA 303
Query: 128 NIKLWDIR--RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEF 185
+L+D+R R+ ++ + FS G+ L + +D+T+ +WD+ G +S
Sbjct: 304 TCRLYDLRADREVAIYSKESIIFGASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSIL 363
Query: 186 PGHTGPVNVVEFHPNEYLLASGSSDRTIRFW 216
GH V+ + P+ SGS D T+R W
Sbjct: 364 FGHENRVSTLRVSPDGTAFCSGSWDHTLRVW 394
Score = 69.3 bits (168), Expect = 1e-11
Identities = 50/215 (23%), Positives = 89/215 (41%), Gaps = 9/215 (4%)
Query: 58 SLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYG 117
+L GH + V + + IV+ SQ G + VWD + + + + P G
Sbjct: 100 TLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWDSFTTNKEHAVTMPCTWVMACAYAPSG 159
Query: 118 EFVASGSQDTNIKLWDI---RRKGCVFRYRG---HSQAVRCLRFSPDGKWLASAADDHTV 171
+A G D ++ + + + + + H+ + F+ + +A+ D T
Sbjct: 160 CAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTASGDGTC 219
Query: 172 KLWDLTAGKMMSEFPGHTGPVNVVEFHPNE--YLLASGSSDRTIRFWDLEKFQVVSCIEG 229
LWD+ +G+++ F GH V ++ P+E SG D+ WD+ Q V E
Sbjct: 220 ALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQCVQAFET 279
Query: 230 EPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPER 263
+ SV + P G SG D + R+Y +R
Sbjct: 280 HESDINSVRYYPSGDAFASGSDDATCRLYDLRADR 314
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 102 bits (255), Expect = 9e-22
Identities = 65/253 (25%), Positives = 117/253 (46%), Gaps = 6/253 (2%)
Query: 18 AHASNVSSLVLG---KASGRLLATGGDDCRVNLWSINKPNCIM--SLTGHTSPVESVRLN 72
AH + S+ G K + + TG D V +W + SL GH V SV ++
Sbjct: 14 AHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDIS 73
Query: 73 TPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLW 132
+ + S IR+WDLE K ++++ + +L F P +++A+G+ + ++
Sbjct: 74 HTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIF 133
Query: 133 DIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPV 192
+ + + + + +SPDGK+LAS A D + ++D+ GK++ GH P+
Sbjct: 134 GVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPI 193
Query: 193 NVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
+ F P+ LL + S D I+ +D++ + + G V +V F PD S D
Sbjct: 194 RSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSD 253
Query: 253 -SLRVYGWEPERC 264
S++V+ C
Sbjct: 254 KSVKVWDVGTRTC 266
Score = 94.7 bits (234), Expect = 2e-19
Identities = 56/224 (25%), Positives = 104/224 (46%), Gaps = 1/224 (0%)
Query: 35 LLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEA 94
+ A+ D + LW + I S+ ++ + + + G+ G + ++ +E+
Sbjct: 78 IAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVES 137
Query: 95 AKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLR 154
K +L I S+ + P G+++ASG+ D I ++DI + GH+ +R L
Sbjct: 138 GKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLT 197
Query: 155 FSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIR 214
FSPD + L +A+DD +K++D+ + GH V V F P++ S SSD++++
Sbjct: 198 FSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVK 257
Query: 215 FWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS-GCQDSLRVY 257
WD+ V V V +N +G + S G + +Y
Sbjct: 258 VWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIY 301
Score = 87.8 bits (216), Expect = 3e-17
Identities = 40/143 (27%), Positives = 77/143 (53%)
Query: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
G+ LA+G D +N++ I + +L GH P+ S+ + +L+V S G I+++D+
Sbjct: 160 GKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219
Query: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRC 152
+ A + TL GH + + ++ F P S S D ++K+WD+ + CV + H V
Sbjct: 220 QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWG 279
Query: 153 LRFSPDGKWLASAADDHTVKLWD 175
++++ +G + S DD + ++D
Sbjct: 280 VKYNGNGSKIVSVGDDQEIHIYD 302
Score = 83.6 bits (205), Expect = 5e-16
Identities = 50/182 (27%), Positives = 86/182 (47%)
Query: 36 LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95
LATG +VN++ + SL + S+ + + + +G+ G I ++D+
Sbjct: 121 LATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATG 180
Query: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRF 155
K+L TL GH I SL F P + + + S D IK++D++ GH+ V + F
Sbjct: 181 KLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAF 240
Query: 156 SPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRF 215
PD S++ D +VK+WD+ + F H V V+++ N + S D+ I
Sbjct: 241 CPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHI 300
Query: 216 WD 217
+D
Sbjct: 301 YD 302
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,946,824
Number of Sequences: 37866
Number of extensions: 1352692
Number of successful extensions: 12578
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 352
Number of HSP's successfully gapped in prelim test: 365
Number of HSP's that attempted gapping in prelim test: 7539
Number of HSP's gapped (non-prelim): 3023
length of query: 655
length of database: 18,247,518
effective HSP length: 109
effective length of query: 546
effective length of database: 14,120,124
effective search space: 7709587704
effective search space used: 7709587704
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.