Search of human proteins with 7657439

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7657439 PCAF associated factor 65 beta isoform a [Homo
sapiens]
         (589 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]   1189   0.0  
gi|69122931 PCAF associated factor 65 beta isoform b [Homo sapiens]   645   0.0  
gi|21071067 TBP-associated factor 5 [Homo sapiens]                    372   e-103
gi|32189425 WD repeat domain 69 [Homo sapiens]                        137   4e-32
gi|113865883 WD repeat domain 38 [Homo sapiens]                       130   4e-30
gi|83779014 katanin p80 subunit B 1 [Homo sapiens]                    127   3e-29
gi|16554629 WD repeat domain 5 [Homo sapiens]                         117   4e-26
gi|16554627 WD repeat domain 5 [Homo sapiens]                         117   4e-26
gi|26665869 WD repeat domain 51B [Homo sapiens]                       117   4e-26
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...   115   9e-26
gi|23199987 WD repeat domain 5B [Homo sapiens]                        115   1e-25
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]   112   1e-24
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [...   111   2e-24
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]            111   2e-24
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]            111   2e-24
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]              110   5e-24
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]            108   1e-23
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [...   105   1e-22
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]         105   1e-22
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]         105   1e-22
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]         105   1e-22
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]           105   1e-22
gi|19913369 transducin beta-like 3 [Homo sapiens]                     105   1e-22
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [...   104   3e-22
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H...   103   3e-22
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H...   103   3e-22
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho...   103   3e-22
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho...   103   3e-22
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]           103   4e-22
gi|19913367 transducin beta-like 1Y [Homo sapiens]                    103   6e-22

>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 1189 bits (3075), Expect = 0.0
 Identities = 589/589 (100%), Positives = 589/589 (100%)

Query: 1   MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA 60
           MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA
Sbjct: 1   MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA 60

Query: 61  APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY 120
           APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY
Sbjct: 61  APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY 120

Query: 121 SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ 180
           SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ
Sbjct: 121 SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ 180

Query: 181 SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE 240
           SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE
Sbjct: 181 SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE 240

Query: 241 VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK 300
           VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK
Sbjct: 241 VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK 300

Query: 301 KLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC 360
           KLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC
Sbjct: 301 KLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC 360

Query: 361 SEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR 420
           SEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR
Sbjct: 361 SEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR 420

Query: 421 IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG 480
           IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG
Sbjct: 421 IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNG 480

Query: 481 KYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
           KYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR
Sbjct: 481 KYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540

Query: 541 NTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH 589
           NTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH
Sbjct: 541 NTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTGITQENQEH 589


>gi|69122931 PCAF associated factor 65 beta isoform b [Homo sapiens]
          Length = 325

 Score =  645 bits (1665), Expect = 0.0
 Identities = 324/324 (100%), Positives = 324/324 (100%)

Query: 1   MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA 60
           MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA
Sbjct: 1   MKRVRTEQIQMAVSCYLKRRQYVDSDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSA 60

Query: 61  APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY 120
           APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY
Sbjct: 61  APCQAEPQQYEVQFGRLRNFLTDSDSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFY 120

Query: 121 SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ 180
           SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ
Sbjct: 121 SRFHGMFLQNASQKDVIEQLQTTQTIQDILSNFKLRAFLDNKYVVRLQEDSYNYLIRYLQ 180

Query: 181 SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE 240
           SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE
Sbjct: 181 SDNNTALCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQNEAALE 240

Query: 241 VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK 300
           VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK
Sbjct: 241 VLQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSK 300

Query: 301 KLKSEPHQVDVSRIHLACDILEEE 324
           KLKSEPHQVDVSRIHLACDILEEE
Sbjct: 301 KLKSEPHQVDVSRIHLACDILEEE 324


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score =  372 bits (956), Expect = e-103
 Identities = 228/632 (36%), Positives = 330/632 (52%), Gaps = 80/632 (12%)

Query: 25  SDGPLKQGLRLSQTAEEMAANLTVQSESGCANIVSAAPCQAEPQQYEVQFGRLRNFLTDS 84
           S   +  G      A     ++ V+ +   + ++SA   Q +P  YE  +  L++F+  S
Sbjct: 169 SGATVVSGSASGPAAPGKVGSVAVEDQPDVSAVLSAYNQQGDPTMYEEYYSGLKHFIECS 228

Query: 85  DSQHSHEVMPLLYPLFVYLHLNLVQNSPKSTVESFYSRFHG----------MFLQNASQK 134
              H  E+  L YPLFV+++L LV N  ++  +SF+ +FHG            L + ++K
Sbjct: 229 LDCHRAELSQLFYPLFVHMYLELVYNQHENEAKSFFEKFHGDQECYYQDDLRVLSSLTKK 288

Query: 135 DVIEQLQTTQTIQDI-LSNFKLRAFLDNKYVVR--LQEDSYNYLIRYLQSD--------- 182
              E ++  +T+ D   S F LR   D+  +++  LQE   N +   +Q           
Sbjct: 289 ---EHMKGNETMLDFRTSKFVLRISRDSYQLLKRHLQEKQNNQIWNIVQEHLYIDIFDGM 345

Query: 183 ----------------------NNT----ALCKVLTLHIHLDVQPA---------KRTDY 207
                                 N +     L K   + + LD +           K+   
Sbjct: 346 PRSKQQIDAMVGSLAGEAKREANKSKVFFGLLKEPEIEVPLDDEDEEGENEEGKPKKKKP 405

Query: 208 QLYASGSSSRSENNGLEPPD-MPSPILQNEAALEVL---QESIKRVKDGPPSLTTICFYA 263
           +  + GS S+ ++    P + +P P L++   L+ +   +E+ KRV+ GP  L +ICFY 
Sbjct: 406 KKDSIGSKSKKQDPNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYT 465

Query: 264 FYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD-ILE 322
           F N  Q L   +++ DS L+A GF +S +++WS+  KKL+S     D+S I    D +LE
Sbjct: 466 FLNAYQGLTAVDVTDDSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLE 525

Query: 323 EEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQG 382
              DE     +E+KIL GH GPVY   F  D + LLS SED ++R W L +FT  V Y+G
Sbjct: 526 RIMDE--KTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKG 583

Query: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
           H YPVWD   SPY  YF SG HDR ARLW+ D   PLRI+AGHLADV+C +FHPNSNY+A
Sbjct: 584 HNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVA 643

Query: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502
           TGS D+TVRLW    GN VR+FTGH+GP+ SL FSPNG++LA+   D R+ LWD+  G +
Sbjct: 644 TGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLM 703

Query: 503 YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPAD------------- 549
             EL+GHTD + SL FS D  ++AS SMDN+VR+WD    +     D             
Sbjct: 704 VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPE 763

Query: 550 GSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
            S   L+G Y  + + V+ + F   NL+L  G
Sbjct: 764 NSQELLLGTYMTKSTPVVHLHFTRRNLVLAAG 795


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score =  137 bits (344), Expect = 4e-32
 Identities = 73/232 (31%), Positives = 117/232 (50%), Gaps = 4/232 (1%)

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDIS-P 394
           K+L+ H  P+ +       S  ++ S D + + WD  S       +GH   V+ +  + P
Sbjct: 86  KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145

Query: 395 YSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS 454
           Y    A+GS D+T +LWS +       + GH A++ C+ F+P S  +ATGS D T +LW 
Sbjct: 146 YGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWD 205

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
            Q G  V    GH   ++SL+F+ +G  + +   D  + +WD  +G     L GH   I+
Sbjct: 206 IQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEIS 265

Query: 515 SLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGV---YTGQM 563
           S +F+ D  LI + SMD + ++WD  N  C A   G   E++     YTG++
Sbjct: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKL 317



 Score =  117 bits (294), Expect = 2e-26
 Identities = 60/229 (26%), Positives = 104/229 (45%)

Query: 339 RGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLY 398
           RGH   +    F   S+ + + S D + + WD+ +       +GH+  +  L  +     
Sbjct: 174 RGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDR 233

Query: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQG 458
             +GS D T  +W  D    + I  GH A++    F+ + + + TGS DKT +LW A  G
Sbjct: 234 IITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNG 293

Query: 459 NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTF 518
             V   TGH   +L   F   GK +A+A  D   +++  A+     +L GH   I+ ++F
Sbjct: 294 KCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISF 353

Query: 519 SPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVL 567
           +P    + + S D + R+WD +   C    +G + E+         N++
Sbjct: 354 NPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIV 402



 Score =  114 bits (286), Expect = 2e-25
 Identities = 68/241 (28%), Positives = 108/241 (44%), Gaps = 1/241 (0%)

Query: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSC-SEDMSIRYWDLGSFTNTVLYQGHAYP 386
           D  +G E+  L GH   VY+  F       ++  S D + + W + +      ++GH   
Sbjct: 120 DTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAE 179

Query: 387 VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGST 446
           +  L  +P S   A+GS D TA+LW       +    GH A++  + F+ + + + TGS 
Sbjct: 180 IVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSF 239

Query: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
           D TV +W A  G  V +  GH   + S +F+ +   + +   D+  KLWD  +G     L
Sbjct: 240 DHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATL 299

Query: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNV 566
            GH D I    F     LIA+AS D + R++      C A  +G   E+  +      N 
Sbjct: 300 TGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNH 359

Query: 567 L 567
           L
Sbjct: 360 L 360



 Score =  109 bits (272), Expect = 8e-24
 Identities = 65/278 (23%), Positives = 113/278 (40%), Gaps = 32/278 (11%)

Query: 260 CFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD 319
           C++ F      +     +P S L+A G  ++  KLW +++                    
Sbjct: 169 CYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQN-------------------- 208

Query: 320 ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379
                       G E+  LRGH   + S  F      +++ S D ++  WD  +     +
Sbjct: 209 ------------GEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNI 256

Query: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
             GH   +     +       +GS D+T +LW       +    GH  ++    F     
Sbjct: 257 LIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGK 316

Query: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499
            +AT S D T R++SA     +    GH G +  ++F+P G +L +   D+  ++WD  +
Sbjct: 317 LIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQT 376

Query: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
           G   + L GHTD I S  F+    ++ + S DN+ R+W
Sbjct: 377 GQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score = 97.8 bits (242), Expect = 2e-20
 Identities = 51/166 (30%), Positives = 83/166 (50%), Gaps = 12/166 (7%)

Query: 417 YPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAF 476
           Y  ++   H+  +  V  + + +   TGS D+T +LW    G  +    GHR  V ++AF
Sbjct: 83  YLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAF 142

Query: 477 -SPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVR 535
            +P G  +A+   D+  KLW + +G  Y   RGHT  I  L+F+P S L+A+ SMD + +
Sbjct: 143 NNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAK 202

Query: 536 VWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
           +WDI+N            E V    G  + ++S+ F      ++TG
Sbjct: 203 LWDIQN-----------GEEVYTLRGHSAEIISLSFNTSGDRIITG 237


>gi|113865883 WD repeat domain 38 [Homo sapiens]
          Length = 314

 Score =  130 bits (326), Expect = 4e-30
 Identities = 80/206 (38%), Positives = 103/206 (50%), Gaps = 4/206 (1%)

Query: 335 MKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISP 394
           +K    H G V S+ F  D   LL+ SED  +  W+  S        GH  PV     SP
Sbjct: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73

Query: 395 YSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS 454
               FAS S D T RLW   R   LR+  GH   V+ V F P+S  LA+G  DK V LW 
Sbjct: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT---LYKELRGHTD 511
            Q G  +RL  GHR  + S  FSP    LA+   D  + +WDL   T    ++ L GH+ 
Sbjct: 134 VQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193

Query: 512 NITSLTFSPDSGLIASASMDNSVRVW 537
           NI+ L +S  SGL+AS S D ++ +W
Sbjct: 194 NISCLCYSA-SGLLASGSWDKTIHIW 218



 Score =  126 bits (317), Expect = 5e-29
 Identities = 82/277 (29%), Positives = 118/277 (42%), Gaps = 36/277 (12%)

Query: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330
           +N++  SPD ++L  G ++ C+  W  RS +L                            
Sbjct: 24  VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQL---------------------------- 55

Query: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390
               +  L GH GPV   RF  D     S S D ++R WD+       + +GH   V  +
Sbjct: 56  ----LWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETV 111

Query: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTV 450
             SP S   ASG  D+   LW       LR+  GH   +    F P  N LATGS D TV
Sbjct: 112 SFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTV 171

Query: 451 RLWSAQQGN---SVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELR 507
            +W  +      S +   GH   +  L +S +G  LAS   D+ + +W   + +L  +L+
Sbjct: 172 HIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLK 230

Query: 508 GHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
           GH   + S+ FSPD   +ASA     V+VWD     C
Sbjct: 231 GHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKC 267



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 50/163 (30%), Positives = 79/163 (48%), Gaps = 11/163 (6%)

Query: 419 LRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSP 478
           ++ +  H  +V+   F P+   L TGS D  V  W  + G  +    GH GPV    FSP
Sbjct: 14  VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73

Query: 479 NGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
           +G   ASA  D  ++LWD+A     + L+GH  ++ +++FSPDS  +AS   D  V +WD
Sbjct: 74  DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWD 133

Query: 539 IRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
           ++           S +++ +  G   ++ S  F      L TG
Sbjct: 134 VQ-----------SGQMLRLLVGHRDSIQSSDFSPTVNCLATG 165



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 63/227 (27%), Positives = 102/227 (44%), Gaps = 14/227 (6%)

Query: 277 SPDSKLLAAGFDNSCIKLWSL-RSKKLKS-EPHQVDVSRIHLACDILEEEDDE------- 327
           SPD  L A+   +  ++LW + R+K L+  + HQ  V  +  + D  +            
Sbjct: 72  SPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVML 131

Query: 328 -DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQ---GH 383
            D  +G  +++L GH   + S+ F    + L + S D ++  WDL   T  V +Q   GH
Sbjct: 132 WDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGH 191

Query: 384 AYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLAT 443
           +  +  L  S   L  ASGS D+T  +W    +  L    GH+  V  + F P+  +LA+
Sbjct: 192 SANISCLCYSASGL-LASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLAS 250

Query: 444 GSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490
               + V++W    G  +    G      + AF+P+GK L S   DQ
Sbjct: 251 AGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQ 297



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 45/182 (24%), Positives = 70/182 (38%), Gaps = 32/182 (17%)

Query: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330
           + +++ SP    LA G  +S + +W LR          V  +  H A             
Sbjct: 150 IQSSDFSPTVNCLATGSWDSTVHIWDLR---------MVTPAVSHQA------------- 187

Query: 331 AGTEMKILRGHCGPVYSTRFLADSSGLL-SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWD 389
                  L GH   +    + A  SGLL S S D +I  W   + +  +  +GH   V  
Sbjct: 188 -------LEGHSANISCLCYSA--SGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKS 238

Query: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
           +  SP  L+ AS  + R  ++W  +    L    G L       F P+   L +G+ D+T
Sbjct: 239 IAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQT 298

Query: 450 VR 451
            R
Sbjct: 299 RR 300


>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
          Length = 655

 Score =  127 bits (319), Expect = 3e-29
 Identities = 64/195 (32%), Positives = 102/195 (52%), Gaps = 2/195 (1%)

Query: 347 STRFLADSSGLLSCS--EDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSH 404
           S+  L  +SG L  +  +D  +  W +      +   GH  PV  + ++       +GS 
Sbjct: 24  SSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQ 83

Query: 405 DRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLF 464
             + R+W  +    LR   GH A++  + FHP   ++A+GS D  ++LW  ++   V  +
Sbjct: 84  SGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRY 143

Query: 465 TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGL 524
            GH   V  L FSP+GK+LASA +D  +KLWDL +G +  E  GHT  +  + F P+  L
Sbjct: 144 RGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYL 203

Query: 525 IASASMDNSVRVWDI 539
           +AS S D ++R WD+
Sbjct: 204 LASGSSDRTIRFWDL 218



 Score =  124 bits (311), Expect = 2e-28
 Identities = 69/200 (34%), Positives = 98/200 (49%), Gaps = 1/200 (0%)

Query: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
           L GH  PV S R       +++ S+  SIR WDL +        GH   +  LD  PY  
Sbjct: 59  LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGE 118

Query: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
           + ASGS D   +LW   R   +  Y GH   V C++F P+  +LA+ + D TV+LW    
Sbjct: 119 FVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTA 178

Query: 458 GNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLT 517
           G  +  F GH GPV  + F PN   LAS   D+ ++ WDL    +   + G    + S+ 
Sbjct: 179 GKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVL 238

Query: 518 FSPDSGLIASASMDNSVRVW 537
           F+PD   + S   D S+RV+
Sbjct: 239 FNPDGCCLYSGCQD-SLRVY 257



 Score =  103 bits (257), Expect = 4e-22
 Identities = 67/227 (29%), Positives = 106/227 (46%), Gaps = 11/227 (4%)

Query: 281 KLLAAGFDNSCIKLWSLRSKK----LKSEPHQVDVSRIHLACDILEEEDDE------DDN 330
           +LLA G D+  + LWS+        L      V+  R++   +++            D  
Sbjct: 34  RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLE 93

Query: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390
           A   ++ L GH   + S  F      + S S+D +I+ WD+        Y+GH+  V  L
Sbjct: 94  AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCL 153

Query: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTV 450
             SP   + AS + D T +LW       +  + GH   V+ V+FHPN   LA+GS+D+T+
Sbjct: 154 RFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTI 213

Query: 451 RLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ-RLKLWD 496
           R W  ++   V    G  GPV S+ F+P+G  L S  +D  R+  W+
Sbjct: 214 RFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSLRVYGWE 260



 Score = 80.5 bits (197), Expect = 4e-15
 Identities = 37/104 (35%), Positives = 56/104 (53%)

Query: 441 LATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
           LATG  D  V LWS  + N +   TGH  PV S+  +   + + +  +   +++WDL + 
Sbjct: 36  LATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAA 95

Query: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
            + + L GH  NI SL F P    +AS S D ++++WDIR   C
Sbjct: 96  KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGC 139



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 45/173 (26%), Positives = 68/173 (39%), Gaps = 32/173 (18%)

Query: 275 EISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTE 334
           +  P  + +A+G  ++ IKLW +R K                               G  
Sbjct: 112 DFHPYGEFVASGSQDTNIKLWDIRRK-------------------------------GCV 140

Query: 335 MKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISP 394
            +  RGH   V   RF  D   L S ++D +++ WDL +      + GH  PV  ++  P
Sbjct: 141 FR-YRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHP 199

Query: 395 YSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTD 447
                ASGS DRT R W  ++   +    G    V  V F+P+   L +G  D
Sbjct: 200 NEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252



 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 39/146 (26%), Positives = 53/146 (36%), Gaps = 32/146 (21%)

Query: 260 CFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD 319
           C + +    Q +     SPD K LA+  D+  +KLW L + K+ SE              
Sbjct: 139 CVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSE-------------- 184

Query: 320 ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379
                               GH GPV    F  +   L S S D +IR+WDL  F     
Sbjct: 185 ------------------FPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSC 226

Query: 380 YQGHAYPVWDLDISPYSLYFASGSHD 405
            +G   PV  +  +P      SG  D
Sbjct: 227 IEGEPGPVRSVLFNPDGCCLYSGCQD 252


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  117 bits (292), Expect = 4e-26
 Identities = 73/283 (25%), Positives = 139/283 (49%), Gaps = 16/283 (5%)

Query: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKS--EPHQVDVSRIHLACD---ILEEED 325
           +++ + SP+ + LA+   +  IK+W     K +     H++ +S +  + D   ++   D
Sbjct: 48  VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107

Query: 326 DE-----DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY 380
           D+     D ++G  +K L+GH   V+   F   S+ ++S S D S+R WD+ +       
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167

Query: 381 QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR-IYAGHLADVDCVKFHPNSN 439
             H+ PV  +  +       S S+D   R+W       L+ +       V  VKF PN  
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 227

Query: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFS---PNGKYLASAGEDQRLKLWD 496
           Y+   + D T++LW   +G  ++ +TGH+     +  +     GK++ S  ED  + +W+
Sbjct: 228 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287

Query: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDN--SVRVW 537
           L +  + ++L+GHTD + S    P   +IASA+++N  ++++W
Sbjct: 288 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score =  116 bits (290), Expect = 7e-26
 Identities = 69/221 (31%), Positives = 108/221 (48%), Gaps = 7/221 (3%)

Query: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--GSFTNTVLYQGHAYPVWDLDISPY 395
           L GH   V S +F  +   L S S D  I+ W    G F  T+   GH   + D+  S  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGISDVAWSSD 98

Query: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
           S    S S D+T ++W       L+   GH   V C  F+P SN + +GS D++VR+W  
Sbjct: 99  SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158

Query: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN--I 513
           + G  ++    H  PV ++ F+ +G  + S+  D   ++WD ASG   K L    DN  +
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI-DDDNPPV 217

Query: 514 TSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSE 554
           + + FSP+   I +A++DN++++WD     C     G  +E
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258



 Score =  111 bits (278), Expect = 2e-24
 Identities = 51/137 (37%), Positives = 78/137 (56%)

Query: 423 AGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKY 482
           AGH   V  VKF PN  +LA+ S DK +++W A  G   +  +GH+  +  +A+S +   
Sbjct: 42  AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101

Query: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
           L SA +D+ LK+WD++SG   K L+GH++ +    F+P S LI S S D SVR+WD++  
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161

Query: 543 YCSAPADGSSSELVGVY 559
            C       S  +  V+
Sbjct: 162 KCLKTLPAHSDPVSAVH 178



 Score =  107 bits (266), Expect = 4e-23
 Identities = 66/237 (27%), Positives = 109/237 (45%), Gaps = 4/237 (1%)

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY 395
           K + GH   +    + +DS+ L+S S+D +++ WD+ S       +GH+  V+  + +P 
Sbjct: 81  KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140

Query: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
           S    SGS D + R+W       L+    H   V  V F+ + + + + S D   R+W  
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200

Query: 456 QQGNSVR-LFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
             G  ++ L      PV  + FSPNGKY+ +A  D  LKLWD + G   K   GH +   
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260

Query: 515 SL--TFSPDSG-LIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLS 568
            +   FS   G  I S S DN V +W+++         G +  ++        N+++
Sbjct: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 35/102 (34%), Positives = 57/102 (55%)

Query: 466 GHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLI 525
           GH   V S+ FSPNG++LAS+  D+ +K+W    G   K + GH   I+ + +S DS L+
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 526 ASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVL 567
            SAS D ++++WD+ +  C     G S+ +        SN++
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score =  117 bits (292), Expect = 4e-26
 Identities = 73/283 (25%), Positives = 139/283 (49%), Gaps = 16/283 (5%)

Query: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKS--EPHQVDVSRIHLACD---ILEEED 325
           +++ + SP+ + LA+   +  IK+W     K +     H++ +S +  + D   ++   D
Sbjct: 48  VSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASD 107

Query: 326 DE-----DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY 380
           D+     D ++G  +K L+GH   V+   F   S+ ++S S D S+R WD+ +       
Sbjct: 108 DKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTL 167

Query: 381 QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLR-IYAGHLADVDCVKFHPNSN 439
             H+ PV  +  +       S S+D   R+W       L+ +       V  VKF PN  
Sbjct: 168 PAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGK 227

Query: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFS---PNGKYLASAGEDQRLKLWD 496
           Y+   + D T++LW   +G  ++ +TGH+     +  +     GK++ S  ED  + +W+
Sbjct: 228 YILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWN 287

Query: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDN--SVRVW 537
           L +  + ++L+GHTD + S    P   +IASA+++N  ++++W
Sbjct: 288 LQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330



 Score =  116 bits (290), Expect = 7e-26
 Identities = 69/221 (31%), Positives = 108/221 (48%), Gaps = 7/221 (3%)

Query: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--GSFTNTVLYQGHAYPVWDLDISPY 395
           L GH   V S +F  +   L S S D  I+ W    G F  T+   GH   + D+  S  
Sbjct: 41  LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTI--SGHKLGISDVAWSSD 98

Query: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
           S    S S D+T ++W       L+   GH   V C  F+P SN + +GS D++VR+W  
Sbjct: 99  SNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158

Query: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN--I 513
           + G  ++    H  PV ++ F+ +G  + S+  D   ++WD ASG   K L    DN  +
Sbjct: 159 KTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI-DDDNPPV 217

Query: 514 TSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSE 554
           + + FSP+   I +A++DN++++WD     C     G  +E
Sbjct: 218 SFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258



 Score =  111 bits (278), Expect = 2e-24
 Identities = 51/137 (37%), Positives = 78/137 (56%)

Query: 423 AGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKY 482
           AGH   V  VKF PN  +LA+ S DK +++W A  G   +  +GH+  +  +A+S +   
Sbjct: 42  AGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNL 101

Query: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
           L SA +D+ LK+WD++SG   K L+GH++ +    F+P S LI S S D SVR+WD++  
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG 161

Query: 543 YCSAPADGSSSELVGVY 559
            C       S  +  V+
Sbjct: 162 KCLKTLPAHSDPVSAVH 178



 Score =  107 bits (266), Expect = 4e-23
 Identities = 66/237 (27%), Positives = 109/237 (45%), Gaps = 4/237 (1%)

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY 395
           K + GH   +    + +DS+ L+S S+D +++ WD+ S       +GH+  V+  + +P 
Sbjct: 81  KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQ 140

Query: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
           S    SGS D + R+W       L+    H   V  V F+ + + + + S D   R+W  
Sbjct: 141 SNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDT 200

Query: 456 QQGNSVR-LFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
             G  ++ L      PV  + FSPNGKY+ +A  D  LKLWD + G   K   GH +   
Sbjct: 201 ASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKY 260

Query: 515 SL--TFSPDSG-LIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLS 568
            +   FS   G  I S S DN V +W+++         G +  ++        N+++
Sbjct: 261 CIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIA 317



 Score = 72.8 bits (177), Expect = 8e-13
 Identities = 35/102 (34%), Positives = 57/102 (55%)

Query: 466 GHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLI 525
           GH   V S+ FSPNG++LAS+  D+ +K+W    G   K + GH   I+ + +S DS L+
Sbjct: 43  GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102

Query: 526 ASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVL 567
            SAS D ++++WD+ +  C     G S+ +        SN++
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLI 144


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score =  117 bits (292), Expect = 4e-26
 Identities = 60/165 (36%), Positives = 85/165 (51%)

Query: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
           ++GH   +  LD+SP     A+ S D    LW+F        Y GH   V  V+F P+ N
Sbjct: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73

Query: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499
            LA+ S D+TVRLW   +      F  H  PV S+ FS +G++LA+A ED+ +K+W +  
Sbjct: 74  LLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYR 133

Query: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
                 L  HT  +    FSPD  LI S S D ++++WD  N  C
Sbjct: 134 QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQC 178



 Score =  109 bits (273), Expect = 6e-24
 Identities = 73/287 (25%), Positives = 133/287 (46%), Gaps = 16/287 (5%)

Query: 264 FYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLR--SKKLKSEPHQVDVSRIHLAC--D 319
           F   +  + + ++SP+ K LA    ++ + LW+ +  ++  +   H+  V+ +  +   +
Sbjct: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGN 73

Query: 320 ILEEEDDE-------DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLG 372
           +L     +        D  G +    + H  PV S  F AD   L + SED SI+ W + 
Sbjct: 74  LLASASRDRTVRLWIPDKRG-KFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM- 131

Query: 373 SFTNTVLYQGHAYPVWD--LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD 430
            +    LY  + +  W      SP      S S D+T ++W       +  ++  +   +
Sbjct: 132 -YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFAN 190

Query: 431 CVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQ 490
            V F+P+   +A+  +D+TV++W  +    ++ +  H G V  ++F P+G YL +A  D 
Sbjct: 191 FVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDG 250

Query: 491 RLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
            LK+ DL  G L   L+GHT  + +++FS    L AS   D  V +W
Sbjct: 251 TLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLW 297



 Score =  109 bits (272), Expect = 8e-24
 Identities = 60/205 (29%), Positives = 91/205 (44%)

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPY 395
           +  +GH   + S     +   L + S D  +  W+         Y GH   V  +  SP+
Sbjct: 12  RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPH 71

Query: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
               AS S DRT RLW  D+      +  H A V  V F  +  +LAT S DK++++WS 
Sbjct: 72  GNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM 131

Query: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515
            +   +     H   V    FSP+G+ + S  ED+ +K+WD  +                
Sbjct: 132 YRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANF 191

Query: 516 LTFSPDSGLIASASMDNSVRVWDIR 540
           + F+P    IASA  D +V+VWD+R
Sbjct: 192 VDFNPSGTCIASAGSDQTVKVWDVR 216



 Score =  107 bits (268), Expect = 2e-23
 Identities = 66/250 (26%), Positives = 117/250 (46%), Gaps = 22/250 (8%)

Query: 262 YAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLW--SLRSKKLKSEPHQVDVSRIHLACD 319
           Y +   + ++ + + SP   LLA+   +  ++LW    R K  + + H   V  +  + D
Sbjct: 54  YRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSAD 113

Query: 320 ---ILEEEDDEDDNAGTEMK-----ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWD- 370
              +    +D+     +  +      L  H   V   +F  D   ++SCSED +I+ WD 
Sbjct: 114 GQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDT 173

Query: 371 -----LGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGH 425
                + +F+++V +         +D +P     AS   D+T ++W       L+ Y  H
Sbjct: 174 TNKQCVNNFSDSVGFANF------VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVH 227

Query: 426 LADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLAS 485
              V+C+ FHP+ NYL T S+D T+++    +G  +    GH GPV +++FS  G+  AS
Sbjct: 228 SGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFAS 287

Query: 486 AGEDQRLKLW 495
            G D ++ LW
Sbjct: 288 GGADTQVLLW 297



 Score =  106 bits (265), Expect = 5e-23
 Identities = 59/203 (29%), Positives = 100/203 (49%), Gaps = 6/203 (2%)

Query: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYW---DLGSFTNTVLYQGHAYPVWDLDISPYS 396
           GH   V S +F    + L S S D ++R W     G F+    ++ H  PV  +D S   
Sbjct: 58  GHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSE---FKAHTAPVRSVDFSADG 114

Query: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQ 456
            + A+ S D++ ++WS  R   L     H   V C KF P+   + + S DKT+++W   
Sbjct: 115 QFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTT 174

Query: 457 QGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSL 516
               V  F+   G    + F+P+G  +ASAG DQ +K+WD+    L +  + H+  +  +
Sbjct: 175 NKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCI 234

Query: 517 TFSPDSGLIASASMDNSVRVWDI 539
           +F P    + +AS D ++++ D+
Sbjct: 235 SFHPSGNYLITASSDGTLKILDL 257



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 19/58 (32%), Positives = 30/58 (51%), Gaps = 10/58 (17%)

Query: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
           +ASA ED  L+ +           +GH   ITSL  SP+   +A+AS D  + +W+ +
Sbjct: 1   MASATEDPVLERY----------FKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFK 48


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score =  115 bits (289), Expect = 9e-26
 Identities = 73/247 (29%), Positives = 114/247 (46%), Gaps = 24/247 (9%)

Query: 334 EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--GSFTNTVLYQGHAYPVWDLD 391
           E   L GH  PV    F    S ++S SED +I+ WD   G F  T+  +GH   V D+ 
Sbjct: 100 EKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTL--KGHTDSVQDIS 157

Query: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVR 451
                   AS S D T +LW F     +R   GH  +V  V   PN +++ + S DKT++
Sbjct: 158 FDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIK 217

Query: 452 LWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD 511
           +W  Q G  V+ FTGHR  V  +  + +G  +AS   DQ +++W +A+     ELR H  
Sbjct: 218 MWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEH 277

Query: 512 NITSLTFSPDSG--------------------LIASASMDNSVRVWDIRNTYCSAPADGS 551
            +  ++++P+S                      + S S D ++++WD+    C     G 
Sbjct: 278 VVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGH 337

Query: 552 SSELVGV 558
            + + GV
Sbjct: 338 DNWVRGV 344



 Score =  105 bits (261), Expect = 2e-22
 Identities = 68/275 (24%), Positives = 107/275 (38%), Gaps = 62/275 (22%)

Query: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV 387
           D   G   + L+GH   V    F      L SCS DM+I+ WD   F       GH + V
Sbjct: 136 DYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNV 195

Query: 388 WDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGH---------------LAD---- 428
             + I P   +  S S D+T ++W     Y ++ + GH               +A     
Sbjct: 196 SSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSND 255

Query: 429 -----------------------VDCVKFHPNSNY--------------------LATGS 445
                                  V+C+ + P S+Y                    L +GS
Sbjct: 256 QTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGS 315

Query: 446 TDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKE 505
            DKT+++W    G  +    GH   V  + F   GK++ S  +D+ L++WD  +    K 
Sbjct: 316 RDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKT 375

Query: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
           L  H   +TSL F   +  + + S+D +V+VW+ R
Sbjct: 376 LNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWECR 410



 Score = 60.5 bits (145), Expect = 4e-09
 Identities = 48/202 (23%), Positives = 86/202 (42%), Gaps = 16/202 (7%)

Query: 257 TTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRI 314
           T  C   F    + +     + D  L+A+  ++  +++W + +K+ K+E   H+  V  I
Sbjct: 223 TGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECI 282

Query: 315 HLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSF 374
             A +         +  G+E K   G  GP            LLS S D +I+ WD+ + 
Sbjct: 283 SWAPE--SSYSSISEATGSETK-KSGKPGPF-----------LLSGSRDKTIKMWDVSTG 328

Query: 375 TNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKF 434
              +   GH   V  +       +  S + D+T R+W +     ++    H   V  + F
Sbjct: 329 MCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDF 388

Query: 435 HPNSNYLATGSTDKTVRLWSAQ 456
           H  + Y+ TGS D+TV++W  +
Sbjct: 389 HKTAPYVVTGSVDQTVKVWECR 410


>gi|23199987 WD repeat domain 5B [Homo sapiens]
          Length = 330

 Score =  115 bits (288), Expect = 1e-25
 Identities = 76/312 (24%), Positives = 147/312 (47%), Gaps = 16/312 (5%)

Query: 242 LQESIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKK 301
           L  S  + K+ P +             + +++ + SP+ + LA+   +  I +W     K
Sbjct: 15  LSSSANQSKEVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGK 74

Query: 302 LKSE--PHQVDVSRIHLACD---ILEEEDDE-----DDNAGTEMKILRGHCGPVYSTRFL 351
            +     H +++S +  + D   ++   DD+     D  +G  +K L+GH   V+   F 
Sbjct: 75  YEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFN 134

Query: 352 ADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLW 411
             S+ ++S S D +++ W++ +         H+ PV  +  +       SGS+D   R+W
Sbjct: 135 PPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194

Query: 412 SFDRTYPLR-IYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGP 470
                  L+ +       V  VKF PN  Y+ T + D T++LW   +G  ++ +TGH+  
Sbjct: 195 DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNE 254

Query: 471 VLSLAFS---PNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIAS 527
              +  +     GK++ S  ED  + +W+L +  + ++L+GHTD + S    P   LIAS
Sbjct: 255 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIAS 314

Query: 528 ASMDN--SVRVW 537
           A+++N  ++++W
Sbjct: 315 AALENDKTIKLW 326



 Score =  111 bits (277), Expect = 2e-24
 Identities = 71/241 (29%), Positives = 113/241 (46%), Gaps = 4/241 (1%)

Query: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLD 391
           G   K L GH   +    + +DSS L+S S+D +++ WD+ S       +GH+  V+  +
Sbjct: 73  GKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCN 132

Query: 392 ISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVR 451
            +P S    SGS D T ++W       L+  + H   V  V F+ + + + +GS D   R
Sbjct: 133 FNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCR 192

Query: 452 LWSAQQGNSVR-LFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHT 510
           +W A  G  ++ L      PV  + FSPNGKY+ +A  D  LKLWD + G   K   GH 
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHK 252

Query: 511 DNITSL--TFSPDSG-LIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVL 567
           +    +   FS   G  I S S DN V +W+++         G +  ++        N++
Sbjct: 253 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLI 312

Query: 568 S 568
           +
Sbjct: 313 A 313



 Score =  110 bits (275), Expect = 4e-24
 Identities = 69/221 (31%), Positives = 107/221 (48%), Gaps = 7/221 (3%)

Query: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL--GSFTNTVLYQGHAYPVWDLDISPY 395
           L GH   V S +F  +   L S S D  I  W    G +  T+   GH   + D+  S  
Sbjct: 37  LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLY--GHNLEISDVAWSSD 94

Query: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSA 455
           S    S S D+T +LW       L+   GH   V C  F+P SN + +GS D+TV++W  
Sbjct: 95  SSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV 154

Query: 456 QQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDN--I 513
           + G  ++  + H  PV ++ F+ +G  + S   D   ++WD ASG   K L    DN  +
Sbjct: 155 KTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTL-VDDDNPPV 213

Query: 514 TSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSE 554
           + + FSP+   I +A++DN++++WD     C     G  +E
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNE 254



 Score =  100 bits (250), Expect = 3e-21
 Identities = 47/136 (34%), Positives = 73/136 (53%)

Query: 424 GHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL 483
           GH   V  VKF PN  +LA+ S D+ + +W A  G   +   GH   +  +A+S +   L
Sbjct: 39  GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98

Query: 484 ASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTY 543
            SA +D+ LKLWD+ SG   K L+GH++ +    F+P S LI S S D +V++W+++   
Sbjct: 99  VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGK 158

Query: 544 CSAPADGSSSELVGVY 559
           C       S  +  V+
Sbjct: 159 CLKTLSAHSDPVSAVH 174


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score =  112 bits (279), Expect = 1e-24
 Identities = 65/206 (31%), Positives = 104/206 (50%), Gaps = 3/206 (1%)

Query: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-GSFTNTVLYQGHAYPVWDLDISPY 395
           +L GH G VY  +F  + S L S   D  I  W++ G   N    +GH+  V +L  +  
Sbjct: 61  LLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHYNTD 120

Query: 396 SLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVD-CVKFHPNSNYLATGSTDKTVRLWS 454
                S S D+T  +W  +    ++   GH + V+ C         + TGS D TV+LW 
Sbjct: 121 GSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKLWD 180

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
            ++  +++ F  +   VL++ F+     + S G D  +K+WDL    L   +RGH D++T
Sbjct: 181 IRKKAAIQTFQ-NTYQVLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMRGHADSVT 239

Query: 515 SLTFSPDSGLIASASMDNSVRVWDIR 540
            L+ S +   + S +MDN+VRVWD+R
Sbjct: 240 GLSLSSEGSYLLSNAMDNTVRVWDVR 265



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 76/285 (26%), Positives = 126/285 (44%), Gaps = 30/285 (10%)

Query: 280 SKLLAAGFDNSCIKLWSLRS---KKLKSEPHQVDVSRIHLACD---ILEEEDDE-----D 328
           S L +AGFD   I LW++          + H   V  +H   D   +     D+     D
Sbjct: 79  STLASAGFDR-LILLWNVYGDCDNYATLKGHSGAVMELHYNTDGSMLFSASTDKTVAVWD 137

Query: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSC--SEDMSIRYWDLGSFTNTVLYQGHAYP 386
              G  +K L+GH   V S  + A     L C  S+D +++ WD+        +Q + Y 
Sbjct: 138 SETGERVKRLKGHTSFVNSC-YPARRGPQLVCTGSDDGTVKLWDIRKKAAIQTFQ-NTYQ 195

Query: 387 VWDLDISPYSLYFASGSHDRTARLWSFDR---TYPLRIYAGHLADVDCVKFHPNSNYLAT 443
           V  +  +  S    SG  D   ++W   +   TY +R   GH   V  +      +YL +
Sbjct: 196 VLAVTFNDTSDQIISGGIDNDIKVWDLRQNKLTYTMR---GHADSVTGLSLSSEGSYLLS 252

Query: 444 GSTDKTVRLWS----AQQGNSVRLFTGH----RGPVLSLAFSPNGKYLASAGEDQRLKLW 495
            + D TVR+W     A +   V++F G+       +L  ++SP+G  +A+   D+ + +W
Sbjct: 253 NAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312

Query: 496 DLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
           D  S  +  +L GH  +I  + F PD  +I SAS D  + + +I+
Sbjct: 313 DTTSRRILYKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 43/126 (34%), Positives = 70/126 (55%), Gaps = 4/126 (3%)

Query: 418 PLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQ-QGNSVRLFTGHRGPVLSLAF 476
           P+ + +GH  +V C KFHPN + LA+   D+ + LW+     ++     GH G V+ L +
Sbjct: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMELHY 117

Query: 477 SPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSG--LIASASMDNSV 534
           + +G  L SA  D+ + +WD  +G   K L+GHT  + S  +    G  L+ + S D +V
Sbjct: 118 NTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNS-CYPARRGPQLVCTGSDDGTV 176

Query: 535 RVWDIR 540
           ++WDIR
Sbjct: 177 KLWDIR 182


>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
           [Homo sapiens]
          Length = 340

 Score =  111 bits (277), Expect = 2e-24
 Identities = 62/203 (30%), Positives = 104/203 (51%), Gaps = 3/203 (1%)

Query: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
           L GH G +   RFL DS  +++ S D +   WD+ +   T  + GH+  V  L +SP   
Sbjct: 139 LPGHTGYLSCCRFLDDSQ-IVTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMR 197

Query: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
            F SG+ D +++LW        + + GH++D++ V F PN    ATGS D T RL+  + 
Sbjct: 198 TFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRA 257

Query: 458 GNSVRLFTGHR--GPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515
              + L++       + S+AFS +G+ L +  +D    +WD   G     L GH + ++ 
Sbjct: 258 DQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSC 317

Query: 516 LTFSPDSGLIASASMDNSVRVWD 538
           L  + D   +A+ S D+ +R+W+
Sbjct: 318 LGVTDDGMAVATGSWDSFLRIWN 340



 Score = 98.6 bits (244), Expect = 1e-20
 Identities = 73/260 (28%), Positives = 116/260 (44%), Gaps = 24/260 (9%)

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV---WDLDI 392
           + LRGH   +Y+  +  DS  L+S S+D  +  WD  S+T   +   HA P+   W +  
Sbjct: 49  RTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWD--SYTTNKM---HAIPLRSSWVMTC 103

Query: 393 S--PYSLYFASGSHDRTARLWSFD-RTYPLRI---YAGHLADVDCVKFHPNSNYLATGST 446
           +  P   Y A G  D    +++   R   +R+     GH   + C +F  +S  + T S 
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFLDDSQ-IVTSSG 162

Query: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
           D T  LW  +       FTGH G V+SL+ SP+ +   S   D   KLWD+  G   +  
Sbjct: 163 DTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSF 222

Query: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNV 566
            GH  +I +++F P+    A+ S D + R++D+R              L+  +   +  +
Sbjct: 223 TGHVSDINAVSFFPNGYAFATGSDDATCRLFDLR---------ADQELLLYSHDNIICGI 273

Query: 567 LSVQFMACNLLLVTGITQEN 586
            SV F     LL+ G    N
Sbjct: 274 TSVAFSKSGRLLLAGYDDFN 293



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 35/181 (19%), Positives = 63/181 (34%), Gaps = 34/181 (18%)

Query: 276 ISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEM 335
           +SPD +   +G  ++  KLW +R                                 G   
Sbjct: 192 LSPDMRTFVSGACDASSKLWDIRD--------------------------------GMCR 219

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY--QGHAYPVWDLDIS 393
           +   GH   + +  F  +     + S+D + R +DL +    +LY        +  +  S
Sbjct: 220 QSFTGHVSDINAVSFFPNGYAFATGSDDATCRLFDLRADQELLLYSHDNIICGITSVAFS 279

Query: 394 PYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLW 453
                  +G  D    +W   +     + AGH   V C+    +   +ATGS D  +R+W
Sbjct: 280 KSGRLLLAGYDDFNCNVWDTLKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLRIW 339

Query: 454 S 454
           +
Sbjct: 340 N 340


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score =  111 bits (277), Expect = 2e-24
 Identities = 74/284 (26%), Positives = 118/284 (41%), Gaps = 10/284 (3%)

Query: 264 FYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLR--SKKLKSEPHQVDVSRIHLACD-- 319
           F      +   + S ++K LA+G  +SC+ +W ++  S+  +   H+  V+ ++ +    
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 320 -ILEEEDDED-----DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS 373
            +     D+       N   E  + R H   V S  F +D    ++ S+D +++ W    
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVK 433
                    H   V     SP      S S D+T +LW       +  Y  H   V  V 
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLK 493
           FHP+   +A    D TV++W  +    ++ +  H   V  L+F P+G YL +A  D  LK
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254

Query: 494 LWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
           + DL  G L   L GH    T++ FS      AS   D  V VW
Sbjct: 255 ILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score =  110 bits (276), Expect = 3e-24
 Identities = 63/202 (31%), Positives = 97/202 (48%)

Query: 339 RGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLY 398
           +GH   V    F  ++  L S S D  +  W +   +    + GH   V  ++ SP    
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75

Query: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQG 458
            ASGS D+T R+W  +      ++  H A V  V F  +     T S DKTV++W+  + 
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135

Query: 459 NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTF 518
             +   + H   V    FSP+G+ + SA +D+ +KLWD +S         H   +T + F
Sbjct: 136 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDF 195

Query: 519 SPDSGLIASASMDNSVRVWDIR 540
            P    IA+A MDN+V+VWD+R
Sbjct: 196 HPSGTCIAAAGMDNTVKVWDVR 217



 Score =  108 bits (270), Expect = 1e-23
 Identities = 67/244 (27%), Positives = 108/244 (44%), Gaps = 10/244 (4%)

Query: 262 YAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLW--SLRSKKLKSEPHQVDVSRIHLACD 319
           Y F   +  +     SP   LLA+G  +  +++W  +++ +      H   V  +H   D
Sbjct: 55  YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD 114

Query: 320 ILEEEDDEDDN-----AGTEMKILRG---HCGPVYSTRFLADSSGLLSCSEDMSIRYWDL 371
                   DD      A    K L     H   V   +F  D   ++S S+D +++ WD 
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174

Query: 372 GSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDC 431
            S      Y  H   V  +D  P     A+   D T ++W       L+ Y  H A V+ 
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234

Query: 432 VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQR 491
           + FHP+ NYL T S+D T+++    +G  +    GH+GP  ++AFS  G+Y AS G D++
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294

Query: 492 LKLW 495
           + +W
Sbjct: 295 VMVW 298



 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 54/165 (32%), Positives = 79/165 (47%)

Query: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
           ++GH   V  +D S  +   ASGS D    +W          + GH   V CV F P+ +
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499
            LA+GS DKTVR+W         +F  H   V S+ F  +G+   +A +D+ +K+W    
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
                 L  H + +    FSPD  LI SAS D +V++WD  +  C
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 40/118 (33%), Positives = 59/118 (50%)

Query: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPN 479
           R + GH   V CV F  N+  LA+GS D  + +W  +  +    FTGH+  V  + FSP+
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 480 GKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
           G  LAS   D+ +++W           R HT  + S+ F  D     +AS D +V+VW
Sbjct: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 32/83 (38%), Positives = 43/83 (51%)

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
           A+  +  R F GHR  V  + FS N K LAS   D  L +W +   +      GH D +T
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 515 SLTFSPDSGLIASASMDNSVRVW 537
            + FSP   L+AS S D +VR+W
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIW 88



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 22/81 (27%), Positives = 36/81 (44%), Gaps = 11/81 (13%)

Query: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYT 560
           +L +  +GH D +T + FS ++  +AS SMD+ + VW ++                  +T
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFT 58

Query: 561 GQMSNVLSVQFMACNLLLVTG 581
           G    V  V F     LL +G
Sbjct: 59  GHKDAVTCVNFSPSGHLLASG 79


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score =  111 bits (277), Expect = 2e-24
 Identities = 74/284 (26%), Positives = 118/284 (41%), Gaps = 10/284 (3%)

Query: 264 FYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLR--SKKLKSEPHQVDVSRIHLACD-- 319
           F      +   + S ++K LA+G  +SC+ +W ++  S+  +   H+  V+ ++ +    
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 320 -ILEEEDDED-----DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS 373
            +     D+       N   E  + R H   V S  F +D    ++ S+D +++ W    
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVK 433
                    H   V     SP      S S D+T +LW       +  Y  H   V  V 
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVD 194

Query: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLK 493
           FHP+   +A    D TV++W  +    ++ +  H   V  L+F P+G YL +A  D  LK
Sbjct: 195 FHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLK 254

Query: 494 LWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
           + DL  G L   L GH    T++ FS      AS   D  V VW
Sbjct: 255 ILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score =  110 bits (276), Expect = 3e-24
 Identities = 63/202 (31%), Positives = 97/202 (48%)

Query: 339 RGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLY 398
           +GH   V    F  ++  L S S D  +  W +   +    + GH   V  ++ SP    
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75

Query: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQG 458
            ASGS D+T R+W  +      ++  H A V  V F  +     T S DKTV++W+  + 
Sbjct: 76  LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQ 135

Query: 459 NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTF 518
             +   + H   V    FSP+G+ + SA +D+ +KLWD +S         H   +T + F
Sbjct: 136 KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDF 195

Query: 519 SPDSGLIASASMDNSVRVWDIR 540
            P    IA+A MDN+V+VWD+R
Sbjct: 196 HPSGTCIAAAGMDNTVKVWDVR 217



 Score =  108 bits (270), Expect = 1e-23
 Identities = 67/244 (27%), Positives = 108/244 (44%), Gaps = 10/244 (4%)

Query: 262 YAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLW--SLRSKKLKSEPHQVDVSRIHLACD 319
           Y F   +  +     SP   LLA+G  +  +++W  +++ +      H   V  +H   D
Sbjct: 55  YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD 114

Query: 320 ILEEEDDEDDN-----AGTEMKILRG---HCGPVYSTRFLADSSGLLSCSEDMSIRYWDL 371
                   DD      A    K L     H   V   +F  D   ++S S+D +++ WD 
Sbjct: 115 GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174

Query: 372 GSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDC 431
            S      Y  H   V  +D  P     A+   D T ++W       L+ Y  H A V+ 
Sbjct: 175 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 234

Query: 432 VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQR 491
           + FHP+ NYL T S+D T+++    +G  +    GH+GP  ++AFS  G+Y AS G D++
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 294

Query: 492 LKLW 495
           + +W
Sbjct: 295 VMVW 298



 Score = 96.3 bits (238), Expect = 7e-20
 Identities = 54/165 (32%), Positives = 79/165 (47%)

Query: 380 YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
           ++GH   V  +D S  +   ASGS D    +W          + GH   V CV F P+ +
Sbjct: 15  FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74

Query: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499
            LA+GS DKTVR+W         +F  H   V S+ F  +G+   +A +D+ +K+W    
Sbjct: 75  LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHR 134

Query: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYC 544
                 L  H + +    FSPD  LI SAS D +V++WD  +  C
Sbjct: 135 QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179



 Score = 75.1 bits (183), Expect = 2e-13
 Identities = 40/118 (33%), Positives = 59/118 (50%)

Query: 420 RIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPN 479
           R + GH   V CV F  N+  LA+GS D  + +W  +  +    FTGH+  V  + FSP+
Sbjct: 13  RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPS 72

Query: 480 GKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
           G  LAS   D+ +++W           R HT  + S+ F  D     +AS D +V+VW
Sbjct: 73  GHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130



 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 32/83 (38%), Positives = 43/83 (51%)

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
           A+  +  R F GHR  V  + FS N K LAS   D  L +W +   +      GH D +T
Sbjct: 6   AEDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVT 65

Query: 515 SLTFSPDSGLIASASMDNSVRVW 537
            + FSP   L+AS S D +VR+W
Sbjct: 66  CVNFSPSGHLLASGSRDKTVRIW 88



 Score = 35.0 bits (79), Expect = 0.19
 Identities = 22/81 (27%), Positives = 36/81 (44%), Gaps = 11/81 (13%)

Query: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYT 560
           +L +  +GH D +T + FS ++  +AS SMD+ + VW ++                  +T
Sbjct: 10  SLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK-----------PQSRAYRFT 58

Query: 561 GQMSNVLSVQFMACNLLLVTG 581
           G    V  V F     LL +G
Sbjct: 59  GHKDAVTCVNFSPSGHLLASG 79


>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
          Length = 1336

 Score =  110 bits (274), Expect = 5e-24
 Identities = 64/209 (30%), Positives = 103/209 (49%), Gaps = 9/209 (4%)

Query: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396
           IL+ H  PV +  +  +   +L+      ++YW   +  N  ++Q H   + +   SP  
Sbjct: 156 ILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQ-SNMNNVKMFQAHKEAIREASFSPTD 214

Query: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTD--KTVRLWS 454
             FA+ S D T R+W F R +  RI  GH ADV CV +HP    + +GS D  + ++ W 
Sbjct: 215 NKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWD 274

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL---RGHTD 511
            + G S+     H+  V+ +  + NG +L +A  D   KL+D+ +  L +EL   RGH  
Sbjct: 275 PKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRN--LKEELQVFRGHKK 332

Query: 512 NITSLTFSP-DSGLIASASMDNSVRVWDI 539
             T++ + P   GL AS   D S+  W +
Sbjct: 333 EATAVAWHPVHEGLFASGGSDGSLLFWHV 361



 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 55/211 (26%), Positives = 91/211 (43%), Gaps = 11/211 (5%)

Query: 335 MKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISP 394
           +K+ + H   +    F    +   +CS+D ++R WD        + +GH   V  +D  P
Sbjct: 195 VKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHP 254

Query: 395 YSLYFASGSHD--RTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRL 452
                 SGS D  +  + W       L     H   V  VK + N N+L T S D   +L
Sbjct: 255 TKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKL 314

Query: 453 WSAQQ-GNSVRLFTGHRGPVLSLAFSPNGKYL-ASAGEDQRLKLWDLASGTLYKELRG-- 508
           +  +     +++F GH+    ++A+ P  + L AS G D  L  W +    + KE+ G  
Sbjct: 315 FDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVG---VEKEVGGME 371

Query: 509 --HTDNITSLTFSPDSGLIASASMDNSVRVW 537
             H   I SL + P   ++ S S D++ + W
Sbjct: 372 MAHEGMIWSLAWHPLGHILCSGSNDHTSKFW 402



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 1/107 (0%)

Query: 432 VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQR 491
           V++ P    L TG++     LW+    N   +   H  PV ++ +S N  ++ +A     
Sbjct: 125 VRWTPEGRRLVTGASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGY 184

Query: 492 LKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
           +K W      + K  + H + I   +FSP     A+ S D +VR+WD
Sbjct: 185 VKYWQSNMNNV-KMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWD 230



 Score = 38.5 bits (88), Expect = 0.017
 Identities = 43/215 (20%), Positives = 84/215 (39%), Gaps = 16/215 (7%)

Query: 264 FYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWS-LRSKKLKS-EPHQVDVSRIHL----A 317
           F   ++ +  A  SP     A   D+  +++W  LR  + +    H  DV  +       
Sbjct: 198 FQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEERILRGHGADVKCVDWHPTKG 257

Query: 318 CDILEEEDDE------DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL 371
             +   +D +      D   G  +  L  H   V   +   + + LL+ S D   + +D+
Sbjct: 258 LVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDI 317

Query: 372 GSFTNTV-LYQGHAYPVWDLDISP-YSLYFASGSHDRTARLWSFDRTYPLR-IYAGHLAD 428
            +    + +++GH      +   P +   FASG  D +   W       +  +   H   
Sbjct: 318 RNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGM 377

Query: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQ-GNSVR 462
           +  + +HP  + L +GS D T + W+  + G+ +R
Sbjct: 378 IWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMR 412



 Score = 37.0 bits (84), Expect = 0.051
 Identities = 31/119 (26%), Positives = 48/119 (40%), Gaps = 10/119 (8%)

Query: 330 NAGTEMKILRGHCGPVYSTRFLADSSGLL-SCSEDMSIRYWDLGSFTNTV-LYQGHAYPV 387
           N   E+++ RGH     +  +     GL  S   D S+ +W +G       +   H   +
Sbjct: 319 NLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEMAHEGMI 378

Query: 388 WDLDISPYSLYFASGSHDRTARLWSFDR-------TYPLRIYAGHLAD-VDCVKFHPNS 438
           W L   P      SGS+D T++ W+ +R        Y L +  G   D V+     PNS
Sbjct: 379 WSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNLNLLPGMSEDGVEYDDLEPNS 437


>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
          Length = 369

 Score =  108 bits (270), Expect = 1e-23
 Identities = 67/244 (27%), Positives = 108/244 (44%), Gaps = 10/244 (4%)

Query: 262 YAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLW--SLRSKKLKSEPHQVDVSRIHLACD 319
           Y F   +  +     SP   LLA+G  +  +++W  +++ +      H   V  +H   D
Sbjct: 17  YRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSD 76

Query: 320 ILEEEDDEDDN-----AGTEMKILRG---HCGPVYSTRFLADSSGLLSCSEDMSIRYWDL 371
                   DD      A    K L     H   V   +F  D   ++S S+D +++ WD 
Sbjct: 77  GQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 136

Query: 372 GSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDC 431
            S      Y  H   V  +D  P     A+   D T ++W       L+ Y  H A V+ 
Sbjct: 137 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196

Query: 432 VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQR 491
           + FHP+ NYL T S+D T+++    +G  +    GH+GP  ++AFS  G+Y AS G D++
Sbjct: 197 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 256

Query: 492 LKLW 495
           + +W
Sbjct: 257 VMVW 260



 Score =  103 bits (257), Expect = 4e-22
 Identities = 56/178 (31%), Positives = 87/178 (48%)

Query: 363 DMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIY 422
           D  +  W +   +    + GH   V  ++ SP     ASGS D+T R+W  +      ++
Sbjct: 2   DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61

Query: 423 AGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKY 482
             H A V  V F  +     T S DKTV++W+  +   +   + H   V    FSP+G+ 
Sbjct: 62  RAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRL 121

Query: 483 LASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
           + SA +D+ +KLWD +S         H   +T + F P    IA+A MDN+V+VWD+R
Sbjct: 122 IVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR 179



 Score =  101 bits (252), Expect = 2e-21
 Identities = 55/200 (27%), Positives = 95/200 (47%)

Query: 340 GHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYF 399
           GH   V    F      L S S D ++R W       + +++ H   V  +        F
Sbjct: 21  GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80

Query: 400 ASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGN 459
            + S D+T ++W+  R   L   + H+  V C KF P+   + + S DKTV+LW      
Sbjct: 81  VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140

Query: 460 SVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFS 519
            V  +  H G V  + F P+G  +A+AG D  +K+WD+ +  L +  + H+  +  L+F 
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFH 200

Query: 520 PDSGLIASASMDNSVRVWDI 539
           P    + +AS D+++++ D+
Sbjct: 201 PSGNYLITASSDSTLKILDL 220



 Score = 84.3 bits (207), Expect = 3e-16
 Identities = 43/123 (34%), Positives = 63/123 (51%)

Query: 422 YAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK 481
           + GH   V CV F P+ + LA+GS DKTVR+W         +F  H   V S+ F  +G+
Sbjct: 19  FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 78

Query: 482 YLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
              +A +D+ +K+W          L  H + +    FSPD  LI SAS D +V++WD  +
Sbjct: 79  SFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 138

Query: 542 TYC 544
             C
Sbjct: 139 REC 141


>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
           [Homo sapiens]
          Length = 340

 Score =  105 bits (262), Expect = 1e-22
 Identities = 57/203 (28%), Positives = 102/203 (50%), Gaps = 3/203 (1%)

Query: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
           L GH G +   RFL D+  +++ S D +   WD+ +   T  + GH   V  L ++P + 
Sbjct: 139 LAGHTGYLSCCRFLDDNQ-IVTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTR 197

Query: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
            F SG+ D +A+LW        + + GH +D++ + F PN N  ATGS D T RL+  + 
Sbjct: 198 LFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRA 257

Query: 458 GNSVRLFTGHR--GPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515
              +  ++       + S++FS +G+ L +  +D    +WD         L GH + ++ 
Sbjct: 258 DQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSC 317

Query: 516 LTFSPDSGLIASASMDNSVRVWD 538
           L  + D   +A+ S D+ +++W+
Sbjct: 318 LGVTDDGMAVATGSWDSFLKIWN 340



 Score =  103 bits (256), Expect = 6e-22
 Identities = 66/214 (30%), Positives = 104/214 (48%), Gaps = 15/214 (7%)

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV---WDLDI 392
           + LRGH   +Y+  +  DS  L+S S+D  +  WD  S+T   +   HA P+   W +  
Sbjct: 49  RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD--SYTTNKV---HAIPLRSSWVMTC 103

Query: 393 S--PYSLYFASGSHDRTARLWSFD-RTYPLRI---YAGHLADVDCVKFHPNSNYLATGST 446
           +  P   Y A G  D    +++   R   +R+    AGH   + C +F  + N + T S 
Sbjct: 104 AYAPSGNYVACGGLDNICSIYNLKTREGNVRVSRELAGHTGYLSCCRFL-DDNQIVTSSG 162

Query: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
           D T  LW  + G     FTGH G V+SL+ +P+ +   S   D   KLWD+  G   +  
Sbjct: 163 DTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTF 222

Query: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIR 540
            GH  +I ++ F P+    A+ S D + R++D+R
Sbjct: 223 TGHESDINAICFFPNGNAFATGSDDATCRLFDLR 256



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 43/171 (25%), Positives = 68/171 (39%), Gaps = 2/171 (1%)

Query: 328 DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV 387
           D   G +     GH G V S     D+   +S + D S + WD+        + GH   +
Sbjct: 170 DIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMCRQTFTGHESDI 229

Query: 388 WDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYA--GHLADVDCVKFHPNSNYLATGS 445
             +   P    FA+GS D T RL+       L  Y+    +  +  V F  +   L  G 
Sbjct: 230 NAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGY 289

Query: 446 TDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496
            D    +W A + +   +  GH   V  L  + +G  +A+   D  LK+W+
Sbjct: 290 DDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN 340



 Score = 37.7 bits (86), Expect = 0.030
 Identities = 33/181 (18%), Positives = 65/181 (35%), Gaps = 34/181 (18%)

Query: 276 ISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEM 335
           ++PD++L  +G  ++  KLW +R                                 G   
Sbjct: 192 LAPDTRLFVSGACDASAKLWDVRE--------------------------------GMCR 219

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY--QGHAYPVWDLDIS 393
           +   GH   + +  F  + +   + S+D + R +DL +    + Y        +  +  S
Sbjct: 220 QTFTGHESDINAICFFPNGNAFATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFS 279

Query: 394 PYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLW 453
                  +G  D    +W   +     + AGH   V C+    +   +ATGS D  +++W
Sbjct: 280 KSGRLLLAGYDDFNCNVWDALKADRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIW 339

Query: 454 S 454
           +
Sbjct: 340 N 340



 Score = 33.5 bits (75), Expect = 0.56
 Identities = 15/39 (38%), Positives = 22/39 (56%)

Query: 504 KELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
           + LRGH   I ++ +  DS L+ SAS D  + +WD   T
Sbjct: 49  RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTT 87


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  105 bits (262), Expect = 1e-22
 Identities = 66/191 (34%), Positives = 96/191 (50%), Gaps = 10/191 (5%)

Query: 359 SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYP 418
           SCS DM I    LG       +QGH   V  +   P  +  AS S D T ++WS  +   
Sbjct: 336 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVC 395

Query: 419 LRIYAGHLADVDCVKF--------HPNSNY-LATGSTDKTVRLWSAQQGNSVRLFTGHRG 469
           +     H  ++  +K+        +PNSN  LA+ S D TVRLW  ++G      T H+ 
Sbjct: 396 IHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE 455

Query: 470 PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASAS 529
           PV S+AFSP+GKYLAS   D+ + +W+  SG L    RG T  I  + ++     + +++
Sbjct: 456 PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASA 514

Query: 530 MDNSVRVWDIR 540
            D SV V D+R
Sbjct: 515 SDGSVCVLDLR 525



 Score =  100 bits (248), Expect = 5e-21
 Identities = 74/297 (24%), Positives = 128/297 (43%), Gaps = 33/297 (11%)

Query: 277 SPDSKLLAAGFDNSCIKLWSLRSKK------------LKSEPHQVDVSRIHLACD----- 319
           +P S LLA+G  +S  ++W+L                ++   H V  ++   + D     
Sbjct: 190 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 249

Query: 320 ILEEEDDEDDNA------GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS 373
            L      D  A      G     L  H GP+++ ++    + +LS   D +   WD  +
Sbjct: 250 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 309

Query: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVK 433
                 +  H+ P  D+D    +  FAS S D    +       P++ + GH  +V+ +K
Sbjct: 310 GEAKQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 368

Query: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK---------YLA 484
           + P+   LA+ S D T+++WS +Q   +     H   + ++ +SP G           LA
Sbjct: 369 WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLA 428

Query: 485 SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
           SA  D  ++LWD+  G     L  H + + S+ FSPD   +AS S D  V +W+ ++
Sbjct: 429 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQS 485



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 66/247 (26%), Positives = 109/247 (44%), Gaps = 16/247 (6%)

Query: 323 EEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-----GSFTNT 377
           E D E +   ++  +LRGH   V+   +   S  L S S D + R W+L     G  T  
Sbjct: 162 EIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQL 221

Query: 378 VLYQ-----GHAYP----VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD 428
           VL       GH  P    V  LD +      A+GS+D  AR+W+ D      +   H   
Sbjct: 222 VLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTL-GQHKGP 280

Query: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
           +  +K++   NY+ +   DKT  +W A  G + + F  H  P L + +  N  + AS   
Sbjct: 281 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCST 339

Query: 489 DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPA 548
           D  + +  L      K  +GHT+ + ++ + P   L+AS S D ++++W ++   C    
Sbjct: 340 DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 399

Query: 549 DGSSSEL 555
              + E+
Sbjct: 400 QAHNKEI 406



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 36/156 (23%), Positives = 59/156 (37%), Gaps = 27/156 (17%)

Query: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL--KSEPHQVDVSRIHLACDILEEEDDED 328
           +N  +  P   LLA+  D+  +K+WS++ +      + H  ++  I  +           
Sbjct: 364 VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS----------- 412

Query: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVW 388
                         GP  S      +  L S S D ++R WD+     T     H  PV+
Sbjct: 413 ------------PTGPATSNP--NSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 458

Query: 389 DLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAG 424
            +  SP   Y ASGS D+   +W+      +  Y G
Sbjct: 459 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 494



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 12/44 (27%), Positives = 24/44 (54%)

Query: 259 ICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL 302
           +C +     ++ + +   SPD K LA+G  + C+ +W+ +S  L
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 488


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score =  105 bits (262), Expect = 1e-22
 Identities = 66/191 (34%), Positives = 96/191 (50%), Gaps = 10/191 (5%)

Query: 359 SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYP 418
           SCS DM I    LG       +QGH   V  +   P  +  AS S D T ++WS  +   
Sbjct: 336 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVC 395

Query: 419 LRIYAGHLADVDCVKF--------HPNSNY-LATGSTDKTVRLWSAQQGNSVRLFTGHRG 469
           +     H  ++  +K+        +PNSN  LA+ S D TVRLW  ++G      T H+ 
Sbjct: 396 IHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE 455

Query: 470 PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASAS 529
           PV S+AFSP+GKYLAS   D+ + +W+  SG L    RG T  I  + ++     + +++
Sbjct: 456 PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASA 514

Query: 530 MDNSVRVWDIR 540
            D SV V D+R
Sbjct: 515 SDGSVCVLDLR 525



 Score =  100 bits (248), Expect = 5e-21
 Identities = 74/297 (24%), Positives = 128/297 (43%), Gaps = 33/297 (11%)

Query: 277 SPDSKLLAAGFDNSCIKLWSLRSKK------------LKSEPHQVDVSRIHLACD----- 319
           +P S LLA+G  +S  ++W+L                ++   H V  ++   + D     
Sbjct: 190 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 249

Query: 320 ILEEEDDEDDNA------GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS 373
            L      D  A      G     L  H GP+++ ++    + +LS   D +   WD  +
Sbjct: 250 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 309

Query: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVK 433
                 +  H+ P  D+D    +  FAS S D    +       P++ + GH  +V+ +K
Sbjct: 310 GEAKQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 368

Query: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK---------YLA 484
           + P+   LA+ S D T+++WS +Q   +     H   + ++ +SP G           LA
Sbjct: 369 WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLA 428

Query: 485 SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
           SA  D  ++LWD+  G     L  H + + S+ FSPD   +AS S D  V +W+ ++
Sbjct: 429 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQS 485



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 66/247 (26%), Positives = 109/247 (44%), Gaps = 16/247 (6%)

Query: 323 EEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-----GSFTNT 377
           E D E +   ++  +LRGH   V+   +   S  L S S D + R W+L     G  T  
Sbjct: 162 EIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQL 221

Query: 378 VLYQ-----GHAYP----VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD 428
           VL       GH  P    V  LD +      A+GS+D  AR+W+ D      +   H   
Sbjct: 222 VLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTL-GQHKGP 280

Query: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
           +  +K++   NY+ +   DKT  +W A  G + + F  H  P L + +  N  + AS   
Sbjct: 281 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCST 339

Query: 489 DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPA 548
           D  + +  L      K  +GHT+ + ++ + P   L+AS S D ++++W ++   C    
Sbjct: 340 DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 399

Query: 549 DGSSSEL 555
              + E+
Sbjct: 400 QAHNKEI 406



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 36/156 (23%), Positives = 59/156 (37%), Gaps = 27/156 (17%)

Query: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL--KSEPHQVDVSRIHLACDILEEEDDED 328
           +N  +  P   LLA+  D+  +K+WS++ +      + H  ++  I  +           
Sbjct: 364 VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS----------- 412

Query: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVW 388
                         GP  S      +  L S S D ++R WD+     T     H  PV+
Sbjct: 413 ------------PTGPATSNP--NSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 458

Query: 389 DLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAG 424
            +  SP   Y ASGS D+   +W+      +  Y G
Sbjct: 459 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 494



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 12/44 (27%), Positives = 24/44 (54%)

Query: 259 ICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL 302
           +C +     ++ + +   SPD K LA+G  + C+ +W+ +S  L
Sbjct: 445 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 488


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  105 bits (262), Expect = 1e-22
 Identities = 66/191 (34%), Positives = 96/191 (50%), Gaps = 10/191 (5%)

Query: 359 SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYP 418
           SCS DM I    LG       +QGH   V  +   P  +  AS S D T ++WS  +   
Sbjct: 387 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVC 446

Query: 419 LRIYAGHLADVDCVKF--------HPNSNY-LATGSTDKTVRLWSAQQGNSVRLFTGHRG 469
           +     H  ++  +K+        +PNSN  LA+ S D TVRLW  ++G      T H+ 
Sbjct: 447 IHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE 506

Query: 470 PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASAS 529
           PV S+AFSP+GKYLAS   D+ + +W+  SG L    RG T  I  + ++     + +++
Sbjct: 507 PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASA 565

Query: 530 MDNSVRVWDIR 540
            D SV V D+R
Sbjct: 566 SDGSVCVLDLR 576



 Score =  100 bits (248), Expect = 5e-21
 Identities = 74/297 (24%), Positives = 128/297 (43%), Gaps = 33/297 (11%)

Query: 277 SPDSKLLAAGFDNSCIKLWSLRSKK------------LKSEPHQVDVSRIHLACD----- 319
           +P S LLA+G  +S  ++W+L                ++   H V  ++   + D     
Sbjct: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300

Query: 320 ILEEEDDEDDNA------GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS 373
            L      D  A      G     L  H GP+++ ++    + +LS   D +   WD  +
Sbjct: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360

Query: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVK 433
                 +  H+ P  D+D    +  FAS S D    +       P++ + GH  +V+ +K
Sbjct: 361 GEAKQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419

Query: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK---------YLA 484
           + P+   LA+ S D T+++WS +Q   +     H   + ++ +SP G           LA
Sbjct: 420 WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLA 479

Query: 485 SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
           SA  D  ++LWD+  G     L  H + + S+ FSPD   +AS S D  V +W+ ++
Sbjct: 480 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQS 536



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 66/247 (26%), Positives = 109/247 (44%), Gaps = 16/247 (6%)

Query: 323 EEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-----GSFTNT 377
           E D E +   ++  +LRGH   V+   +   S  L S S D + R W+L     G  T  
Sbjct: 213 EIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQL 272

Query: 378 VLYQ-----GHAYP----VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD 428
           VL       GH  P    V  LD +      A+GS+D  AR+W+ D      +   H   
Sbjct: 273 VLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTL-GQHKGP 331

Query: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
           +  +K++   NY+ +   DKT  +W A  G + + F  H  P L + +  N  + AS   
Sbjct: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCST 390

Query: 489 DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPA 548
           D  + +  L      K  +GHT+ + ++ + P   L+AS S D ++++W ++   C    
Sbjct: 391 DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450

Query: 549 DGSSSEL 555
              + E+
Sbjct: 451 QAHNKEI 457



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 36/156 (23%), Positives = 59/156 (37%), Gaps = 27/156 (17%)

Query: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL--KSEPHQVDVSRIHLACDILEEEDDED 328
           +N  +  P   LLA+  D+  +K+WS++ +      + H  ++  I  +           
Sbjct: 415 VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS----------- 463

Query: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVW 388
                         GP  S      +  L S S D ++R WD+     T     H  PV+
Sbjct: 464 ------------PTGPATSNP--NSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509

Query: 389 DLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAG 424
            +  SP   Y ASGS D+   +W+      +  Y G
Sbjct: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 12/44 (27%), Positives = 24/44 (54%)

Query: 259 ICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL 302
           +C +     ++ + +   SPD K LA+G  + C+ +W+ +S  L
Sbjct: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 539


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score =  105 bits (262), Expect = 1e-22
 Identities = 66/191 (34%), Positives = 96/191 (50%), Gaps = 10/191 (5%)

Query: 359 SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYP 418
           SCS DM I    LG       +QGH   V  +   P  +  AS S D T ++WS  +   
Sbjct: 387 SCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVC 446

Query: 419 LRIYAGHLADVDCVKF--------HPNSNY-LATGSTDKTVRLWSAQQGNSVRLFTGHRG 469
           +     H  ++  +K+        +PNSN  LA+ S D TVRLW  ++G      T H+ 
Sbjct: 447 IHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQE 506

Query: 470 PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASAS 529
           PV S+AFSP+GKYLAS   D+ + +W+  SG L    RG T  I  + ++     + +++
Sbjct: 507 PVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG-TGGIFEVCWNARGDKVGASA 565

Query: 530 MDNSVRVWDIR 540
            D SV V D+R
Sbjct: 566 SDGSVCVLDLR 576



 Score =  100 bits (248), Expect = 5e-21
 Identities = 74/297 (24%), Positives = 128/297 (43%), Gaps = 33/297 (11%)

Query: 277 SPDSKLLAAGFDNSCIKLWSLRSKK------------LKSEPHQVDVSRIHLACD----- 319
           +P S LLA+G  +S  ++W+L                ++   H V  ++   + D     
Sbjct: 241 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNG 300

Query: 320 ILEEEDDEDDNA------GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS 373
            L      D  A      G     L  H GP+++ ++    + +LS   D +   WD  +
Sbjct: 301 TLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHT 360

Query: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVK 433
                 +  H+ P  D+D    +  FAS S D    +       P++ + GH  +V+ +K
Sbjct: 361 GEAKQQFPFHSAPALDVDWQNNTT-FASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIK 419

Query: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK---------YLA 484
           + P+   LA+ S D T+++WS +Q   +     H   + ++ +SP G           LA
Sbjct: 420 WDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLA 479

Query: 485 SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
           SA  D  ++LWD+  G     L  H + + S+ FSPD   +AS S D  V +W+ ++
Sbjct: 480 SASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQS 536



 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 66/247 (26%), Positives = 109/247 (44%), Gaps = 16/247 (6%)

Query: 323 EEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-----GSFTNT 377
           E D E +   ++  +LRGH   V+   +   S  L S S D + R W+L     G  T  
Sbjct: 213 EIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQL 272

Query: 378 VLYQ-----GHAYP----VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD 428
           VL       GH  P    V  LD +      A+GS+D  AR+W+ D      +   H   
Sbjct: 273 VLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTL-GQHKGP 331

Query: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
           +  +K++   NY+ +   DKT  +W A  G + + F  H  P L + +  N  + AS   
Sbjct: 332 IFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTF-ASCST 390

Query: 489 DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPA 548
           D  + +  L      K  +GHT+ + ++ + P   L+AS S D ++++W ++   C    
Sbjct: 391 DMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDL 450

Query: 549 DGSSSEL 555
              + E+
Sbjct: 451 QAHNKEI 457



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 36/156 (23%), Positives = 59/156 (37%), Gaps = 27/156 (17%)

Query: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL--KSEPHQVDVSRIHLACDILEEEDDED 328
           +N  +  P   LLA+  D+  +K+WS++ +      + H  ++  I  +           
Sbjct: 415 VNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWS----------- 463

Query: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVW 388
                         GP  S      +  L S S D ++R WD+     T     H  PV+
Sbjct: 464 ------------PTGPATSNP--NSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVY 509

Query: 389 DLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAG 424
            +  SP   Y ASGS D+   +W+      +  Y G
Sbjct: 510 SVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRG 545



 Score = 32.0 bits (71), Expect = 1.6
 Identities = 12/44 (27%), Positives = 24/44 (54%)

Query: 259 ICFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKL 302
           +C +     ++ + +   SPD K LA+G  + C+ +W+ +S  L
Sbjct: 496 VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNL 539


>gi|19913369 transducin beta-like 3 [Homo sapiens]
          Length = 808

 Score =  105 bits (262), Expect = 1e-22
 Identities = 71/271 (26%), Positives = 117/271 (43%), Gaps = 19/271 (7%)

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL---GSFTNTVLYQGHAYPVWDLDI 392
           +IL GH   V +           SC++D S+R W +   G         GH + V  +  
Sbjct: 370 QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCC 429

Query: 393 SPYSLYF-ASGSHDRTARLWSFDRTY----------PLRIYAG-----HLADVDCVKFHP 436
           S     F  +GS D T +LW   +            P+ + A      H  D++ V   P
Sbjct: 430 SRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAP 489

Query: 437 NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD 496
           N   LATGS D+T +LW+  Q   + +F+GHR  +  + FSP  + LA+A  D  +KLW 
Sbjct: 490 NDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWA 549

Query: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELV 556
           L   +  K   GH  ++  + F      + S+  D  V++W I+N  C    D    ++ 
Sbjct: 550 LQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVW 609

Query: 557 GVYTGQMSNVLSVQFMACNLLLVTGITQENQ 587
           G++  ++ +          ++L   +T+  Q
Sbjct: 610 GLHCSRLDDHALTGASDSRVILWKDVTEAEQ 640



 Score =  104 bits (260), Expect = 2e-22
 Identities = 78/303 (25%), Positives = 137/303 (45%), Gaps = 36/303 (11%)

Query: 267 TEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEE--- 323
           +E++L+   + P+   +    ++ C+K++ L++   +      D+    LA D+  +   
Sbjct: 334 SEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIV---LALDVFRKGWL 390

Query: 324 ----EDDED------DNAGTEMKILRGHCGPVYSTRFLADS----SGLLSCSEDMSIRYW 369
                 D+       + AG  M + +G  G  +S   +  S    S L++ S+D +++ W
Sbjct: 391 FASCAKDQSVRIWRMNKAGQVMCVAQGS-GHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449

Query: 370 DLGSFT---NTVLYQG------------HAYPVWDLDISPYSLYFASGSHDRTARLWSFD 414
            L       NT    G            H   +  + I+P     A+GS DRTA+LW+  
Sbjct: 450 PLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALP 509

Query: 415 RTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSL 474
           +   L +++GH   + CV+F P    LAT S D T++LW+ Q  + ++ F GH   VL +
Sbjct: 510 QCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDASVLKV 569

Query: 475 AFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSV 534
           AF   G  L S+G D  +KLW + +    + L  H D +  L  S       + + D+ V
Sbjct: 570 AFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRV 629

Query: 535 RVW 537
            +W
Sbjct: 630 ILW 632



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 72/274 (26%), Positives = 109/274 (39%), Gaps = 32/274 (11%)

Query: 321 LEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY 380
           LE+ED ED                + +     D+  L++ S  + +  W     + T L+
Sbjct: 61  LEQEDQED----------------ITAFDLSPDNEVLVTASRALLLAQWAWQEGSVTRLW 104

Query: 381 QG-HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
           +  H  PV  +   P S   A+G  D   R+W   R Y    + G    V  V FHP+  
Sbjct: 105 KAIHTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPT 164

Query: 440 YLA--TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDL 497
            L   + +TD  +R+WS Q  + + + T H   V SLAFS +G  + S+G D+   +WDL
Sbjct: 165 RLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDL 224

Query: 498 AS--GTLYKELRGHTDNITSLTFSPDSGL--------IASASMDNSVRVWDIRN---TYC 544
            S   T    +    +    L   P S L          +A    ++RVW+  +    Y 
Sbjct: 225 QSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYT 284

Query: 545 SAPADGSSSELVGVYTGQMSNVLSVQFMACNLLL 578
            A   G   EL        + V+       NLLL
Sbjct: 285 QAQPPGPGQELTHCTLAHTAGVVLTATADHNLLL 318



 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 71/291 (24%), Positives = 111/291 (38%), Gaps = 27/291 (9%)

Query: 273 TAEISPDSKLLAAGFDNSCIKLWSL----RSKKLKSEPHQVDVSRIHLACDILEEEDDED 328
           T    P S LLA G  +  +++W +     +   +  P  V +   H     L       
Sbjct: 114 TMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSAT 173

Query: 329 DNA--------GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS--FTNTV 378
           D A         + + +L  H   V S  F AD   +LS   D     WDL S   T TV
Sbjct: 174 DAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTV 233

Query: 379 -LYQG-------HAYPVWDLDISPYSLYFASGSHDRTARLW---SFDRTYPLRIYAGHLA 427
            +++           PV  L +    LYF +     T R+W   S    Y      G   
Sbjct: 234 PVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQ 293

Query: 428 DVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAF-SPNGKYLASA 486
           ++        +  + T + D  + L+ A+     + F G+   VL + F  P   ++  A
Sbjct: 294 ELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLDVRFLGPEDSHVVVA 353

Query: 487 GEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
                LK+++L +    + L GHTD + +L       L AS + D SVR+W
Sbjct: 354 SNSPCLKVFELQTSAC-QILHGHTDIVLALDVFRKGWLFASCAKDQSVRIW 403


>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
           [Homo sapiens]
          Length = 340

 Score =  104 bits (259), Expect = 3e-22
 Identities = 58/203 (28%), Positives = 103/203 (50%), Gaps = 3/203 (1%)

Query: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
           L GH G +   RFL D+  +++ S D +   WD+ +   TV + GH+  V  L ++P   
Sbjct: 139 LPGHTGYLSCCRFLDDNQ-IITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGR 197

Query: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457
            F SG+ D + +LW    +   + + GH +D++ V F PN     TGS D T RL+  + 
Sbjct: 198 TFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRA 257

Query: 458 GNSVRLFTGHR--GPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITS 515
              + +++       + S+AFS +G+ L +  +D    +WD   G     L GH + ++ 
Sbjct: 258 DQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSC 317

Query: 516 LTFSPDSGLIASASMDNSVRVWD 538
           L  + D   +A+ S D+ +++W+
Sbjct: 318 LGVTDDGMAVATGSWDSFLKIWN 340



 Score = 95.1 bits (235), Expect = 2e-19
 Identities = 71/260 (27%), Positives = 115/260 (44%), Gaps = 24/260 (9%)

Query: 336 KILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV---WDLDI 392
           + LRGH   +Y+  +  DS  L+S S+D  +  WD  S+T   +   HA P+   W +  
Sbjct: 49  RTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWD--SYTTNKV---HAIPLRSSWVMTC 103

Query: 393 S--PYSLYFASGSHDRTARLWSFD-RTYPLRI---YAGHLADVDCVKFHPNSNYLATGST 446
           +  P   + A G  D    ++S   R   +R+     GH   + C +F  + N + T S 
Sbjct: 104 AYAPSGNFVACGGLDNICSIYSLKTREGNVRVSRELPGHTGYLSCCRFL-DDNQIITSSG 162

Query: 447 DKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
           D T  LW  + G     F GH G V+SL+ +P+G+   S   D  +KLWD+      +  
Sbjct: 163 DTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTF 222

Query: 507 RGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNV 566
            GH  +I ++ F P+     + S D + R++D+R              L+  +   +  +
Sbjct: 223 IGHESDINAVAFFPNGYAFTTGSDDATCRLFDLR---------ADQELLMYSHDNIICGI 273

Query: 567 LSVQFMACNLLLVTGITQEN 586
            SV F     LL+ G    N
Sbjct: 274 TSVAFSRSGRLLLAGYDDFN 293



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 65/263 (24%), Positives = 103/263 (39%), Gaps = 27/263 (10%)

Query: 255 SLTTICFYAFYNTEQLLNTAEISPDSKLLAAG-FDNSCIKLWSLRSKKLKSEPHQVDVSR 313
           S TT   +A       + T   +P    +A G  DN C  ++SL++++       V VSR
Sbjct: 84  SYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNIC-SIYSLKTRE-----GNVRVSR 137

Query: 314 I------HLAC-------DILEEEDDE-----DDNAGTEMKILRGHCGPVYSTRFLADSS 355
                  +L+C        I+    D      D   G +     GH G V S     D  
Sbjct: 138 ELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGR 197

Query: 356 GLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDR 415
             +S + D SI+ WD+        + GH   +  +   P    F +GS D T RL+    
Sbjct: 198 TFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRA 257

Query: 416 TYPLRIYA--GHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLS 473
              L +Y+    +  +  V F  +   L  G  D    +W A +G+   +  GH   V  
Sbjct: 258 DQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSC 317

Query: 474 LAFSPNGKYLASAGEDQRLKLWD 496
           L  + +G  +A+   D  LK+W+
Sbjct: 318 LGVTDDGMAVATGSWDSFLKIWN 340


>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
            sapiens]
          Length = 1205

 Score =  103 bits (258), Expect = 3e-22
 Identities = 81/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%)

Query: 265  YNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD--- 319
            Y TE  ++   +SP  + +A G +N  I++  L + ++      H+  V  I    D   
Sbjct: 915  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 974

Query: 320  ILEEEDDEDDNAGT----EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375
            ++   DD +         +   LRGH   V   R L +S  LLS S D +++ W++ +  
Sbjct: 975  LISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGN 1033

Query: 376  NTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435
                +  H   V   DIS  +  F+S S D+TA++WSFD   PL    GH   V C  F 
Sbjct: 1034 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1093

Query: 436  PNSNYLATGSTDKTVRLWSAQQGNSVRL--------FTGHRGPVLSLAFSPNGKYLASAG 487
             +S  LATG  +  +R+W+   G  + L           H G V  L FSP+GK L SAG
Sbjct: 1094 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1153

Query: 488  EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD 521
                +K W++ +G   +    +  N+  +  SPD
Sbjct: 1154 --GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1185



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)

Query: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
           H   V+    S      AS   D+T +++  +    L     H  +V C  F  +  ++A
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673

Query: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDLASG 500
           T S DK V++W++  G  V  +  H   V    F+ +  +L  A+   D  LKLWDL   
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733

Query: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
                + GHT+++    FSPD  L+AS S D ++++WD
Sbjct: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 65/267 (24%), Positives = 113/267 (42%), Gaps = 18/267 (6%)

Query: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV--WD 389
           G ++  ++ H   V    F  D   + +CS D  ++ W+  +      Y  H+  V    
Sbjct: 647 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCH 706

Query: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
              S + L  A+GS D   +LW  ++        GH   V+  +F P+   LA+ S D T
Sbjct: 707 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 766

Query: 450 VRLWSAQQGNSVR------LFTGHRGP-------VLSLAFSPNGKYLASAGEDQRLKLWD 496
           ++LW A   N  +       F     P       V   ++S +G  +  A ++ ++ LW+
Sbjct: 767 LKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWN 825

Query: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELV 556
             S +   + RGH   +  + FSPD     ++S D ++R+W+ +   C   A     E+ 
Sbjct: 826 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVD 884

Query: 557 GVYTGQMSNVLSVQFMACNLLLVTGIT 583
            V+      VL+V  +   L L+ G T
Sbjct: 885 VVFQENEVMVLAVDHIR-RLQLINGRT 910



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 49/172 (28%), Positives = 75/172 (43%), Gaps = 2/172 (1%)

Query: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396
           ++R H   VY   F  D   + SC  D +++ +   +    +  + H   V     S   
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669

Query: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL--ATGSTDKTVRLWS 454
            + A+ S D+  ++W+      +  Y  H   V+C  F  +S++L  ATGS+D  ++LW 
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
             Q        GH   V    FSP+ K LAS   D  LKLWD  S    K +
Sbjct: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSI 781



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 67/279 (24%), Positives = 113/279 (40%), Gaps = 25/279 (8%)

Query: 277  SPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMK 336
            SPD        D+  I+LW  +     S         +    D++ +E++    A   ++
Sbjct: 848  SPDGSSFLTSSDDQTIRLWETKKVCKNS------AVMLKQEVDVVFQENEVMVLAVDHIR 901

Query: 337  ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS---------FTNTVLYQG---HA 384
             L+   G      +L ++  +  C     ++Y   G            N  ++Q    H 
Sbjct: 902  RLQLINGRTGQIDYLTEAQ-VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 960

Query: 385  YPVWDLDISPYSLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
              VW +  +       S S D   ++W++  D+   LR   GH   V   +   NS  L+
Sbjct: 961  KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRLLS 1017

Query: 443  TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502
              S D TV++W+   GN  + F  H+G VLS   S +    +S   D+  K+W       
Sbjct: 1018 W-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1076

Query: 503  YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
              ELRGH   +    FS DS L+A+   +  +R+W++ N
Sbjct: 1077 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1115



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 68/312 (21%), Positives = 113/312 (36%), Gaps = 81/312 (25%)

Query: 282 LLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGH 341
           LLA G  +  +KLW L  K+ ++                                 + GH
Sbjct: 715 LLATGSSDCFLKLWDLNQKECRNT--------------------------------MFGH 742

Query: 342 CGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAY------PVWDLD-ISP 394
              V   RF  D   L SCS D +++ WD  S           +      P  D++ I  
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVK 802

Query: 395 YSLYFASGSHDRTAR-----LWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
              + A G+    A      LW+ D    +    GHL+ V  V F P+ +   T S D+T
Sbjct: 803 CCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 862

Query: 450 VRLWSAQ------------------QGNSV-----------RLFTGHRGPVLSLA----- 475
           +RLW  +                  Q N V           +L  G  G +  L      
Sbjct: 863 IRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVS 922

Query: 476 ---FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDN 532
               SP+ +Y+A   E+  +++ +L +  +++    H   +  + F+ D   + S+S D 
Sbjct: 923 CCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDA 982

Query: 533 SVRVWDIRNTYC 544
            ++VW+ +   C
Sbjct: 983 EIQVWNWQLDKC 994



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query: 467 HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIA 526
           H   V    FS +G+ +AS G D+ L+++   +G    E++ H D +    FS D   IA
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673

Query: 527 SASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQF--MACNLLLVTG 581
           + S+D  V++W           +  + ELV  Y      V    F   + +LLL TG
Sbjct: 674 TCSVDKKVKIW-----------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 719


>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
            sapiens]
          Length = 1248

 Score =  103 bits (258), Expect = 3e-22
 Identities = 81/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%)

Query: 265  YNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD--- 319
            Y TE  ++   +SP  + +A G +N  I++  L + ++      H+  V  I    D   
Sbjct: 958  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1017

Query: 320  ILEEEDDEDDNAGT----EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375
            ++   DD +         +   LRGH   V   R L +S  LLS S D +++ W++ +  
Sbjct: 1018 LISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGN 1076

Query: 376  NTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435
                +  H   V   DIS  +  F+S S D+TA++WSFD   PL    GH   V C  F 
Sbjct: 1077 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1136

Query: 436  PNSNYLATGSTDKTVRLWSAQQGNSVRL--------FTGHRGPVLSLAFSPNGKYLASAG 487
             +S  LATG  +  +R+W+   G  + L           H G V  L FSP+GK L SAG
Sbjct: 1137 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1196

Query: 488  EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD 521
                +K W++ +G   +    +  N+  +  SPD
Sbjct: 1197 --GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1228



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)

Query: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
           H   V+    S      AS   D+T +++  +    L     H  +V C  F  +  ++A
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673

Query: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDLASG 500
           T S DK V++W++  G  V  +  H   V    F+ +  +L  A+   D  LKLWDL   
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 733

Query: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
                + GHT+++    FSPD  L+AS S D ++++WD
Sbjct: 734 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 771



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 26/263 (9%)

Query: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396
           ++R H   VY   F  D   + SC  D +++ +   +    +  + H   V     S   
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 669

Query: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL--ATGSTDKTVRLWS 454
            + A+ S D+  ++W+      +  Y  H   V+C  F  +S++L  ATGS+D  ++LW 
Sbjct: 670 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 729

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT---------LYKE 505
             Q        GH   V    FSP+ K LAS   D  LKLWD  S            +  
Sbjct: 730 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 789

Query: 506 LRGHTDN----ITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTG 561
           L    ++    +   ++S D   I  A+  N + ++DI           +S  L  ++TG
Sbjct: 790 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIH----------TSGLLGEIHTG 838

Query: 562 QMSNVLSVQFMACNLLLVTGITQ 584
             S +    F   N L V  ++Q
Sbjct: 839 HHSTIQYCDFSPQNHLAVVALSQ 861



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 67/279 (24%), Positives = 113/279 (40%), Gaps = 25/279 (8%)

Query: 277  SPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMK 336
            SPD        D+  I+LW  +     S         +    D++ +E++    A   ++
Sbjct: 891  SPDGSSFLTSSDDQTIRLWETKKVCKNS------AVMLKQEVDVVFQENEVMVLAVDHIR 944

Query: 337  ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS---------FTNTVLYQG---HA 384
             L+   G      +L ++  +  C     ++Y   G            N  ++Q    H 
Sbjct: 945  RLQLINGRTGQIDYLTEAQ-VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 1003

Query: 385  YPVWDLDISPYSLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
              VW +  +       S S D   ++W++  D+   LR   GH   V   +   NS  L+
Sbjct: 1004 KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRLLS 1060

Query: 443  TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502
              S D TV++W+   GN  + F  H+G VLS   S +    +S   D+  K+W       
Sbjct: 1061 W-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1119

Query: 503  YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
              ELRGH   +    FS DS L+A+   +  +R+W++ N
Sbjct: 1120 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1158



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 68/309 (22%), Positives = 111/309 (35%), Gaps = 59/309 (19%)

Query: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV--WD 389
           G ++  ++ H   V    F  D   + +CS D  ++ W+  +      Y  H+  V    
Sbjct: 647 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCH 706

Query: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
              S + L  A+GS D   +LW  ++        GH   V+  +F P+   LA+ S D T
Sbjct: 707 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 766

Query: 450 VRLWSAQQG-------------------------------------------NSVRLF-- 464
           ++LW A                                              N + LF  
Sbjct: 767 LKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDI 826

Query: 465 ----------TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
                     TGH   +    FSP       A     ++LW+  S +   + RGH   + 
Sbjct: 827 HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVH 886

Query: 515 SLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMAC 574
            + FSPD     ++S D ++R+W+ +   C   A     E+  V+      VL+V  +  
Sbjct: 887 GVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIR- 944

Query: 575 NLLLVTGIT 583
            L L+ G T
Sbjct: 945 RLQLINGRT 953



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 68/322 (21%), Positives = 125/322 (38%), Gaps = 56/322 (17%)

Query: 260  CFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD 319
            C    +     +N    SPD KLLA+   +  +KLW   S    +E   ++V +      
Sbjct: 735  CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA---NERKSINVKQF----- 786

Query: 320  ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379
             L  ED ++D     M+++   C       + AD + ++  +++    +    S     +
Sbjct: 787  FLNLEDPQED-----MEVIVKCCS------WSADGARIMVAAKNKIFLFDIHTSGLLGEI 835

Query: 380  YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
            + GH   +   D SP +             LW+ D    +    GHL+ V  V F P+ +
Sbjct: 836  HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 895

Query: 440  YLATGSTDKTVRLWSAQ------------------QGNSV-----------RLFTGHRGP 470
               T S D+T+RLW  +                  Q N V           +L  G  G 
Sbjct: 896  SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 955

Query: 471  VLSLA--------FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDS 522
            +  L          SP+ +Y+A   E+  +++ +L +  +++    H   +  + F+ D 
Sbjct: 956  IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 1015

Query: 523  GLIASASMDNSVRVWDIRNTYC 544
              + S+S D  ++VW+ +   C
Sbjct: 1016 KTLISSSDDAEIQVWNWQLDKC 1037


>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
            sapiens]
          Length = 1194

 Score =  103 bits (258), Expect = 3e-22
 Identities = 81/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%)

Query: 265  YNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD--- 319
            Y TE  ++   +SP  + +A G +N  I++  L + ++      H+  V  I    D   
Sbjct: 904  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 963

Query: 320  ILEEEDDEDDNAGT----EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375
            ++   DD +         +   LRGH   V   R L +S  LLS S D +++ W++ +  
Sbjct: 964  LISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGN 1022

Query: 376  NTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435
                +  H   V   DIS  +  F+S S D+TA++WSFD   PL    GH   V C  F 
Sbjct: 1023 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1082

Query: 436  PNSNYLATGSTDKTVRLWSAQQGNSVRL--------FTGHRGPVLSLAFSPNGKYLASAG 487
             +S  LATG  +  +R+W+   G  + L           H G V  L FSP+GK L SAG
Sbjct: 1083 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1142

Query: 488  EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD 521
                +K W++ +G   +    +  N+  +  SPD
Sbjct: 1143 --GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1174



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)

Query: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
           H   V+    S      AS   D+T +++  +    L     H  +V C  F  +  ++A
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662

Query: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDLASG 500
           T S DK V++W++  G  V  +  H   V    F+ +  +L  A+   D  LKLWDL   
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722

Query: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
                + GHT+++    FSPD  L+AS S D ++++WD
Sbjct: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 65/267 (24%), Positives = 113/267 (42%), Gaps = 18/267 (6%)

Query: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV--WD 389
           G ++  ++ H   V    F  D   + +CS D  ++ W+  +      Y  H+  V    
Sbjct: 636 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCH 695

Query: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
              S + L  A+GS D   +LW  ++        GH   V+  +F P+   LA+ S D T
Sbjct: 696 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 755

Query: 450 VRLWSAQQGNSVR------LFTGHRGP-------VLSLAFSPNGKYLASAGEDQRLKLWD 496
           ++LW A   N  +       F     P       V   ++S +G  +  A ++ ++ LW+
Sbjct: 756 LKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKN-KIFLWN 814

Query: 497 LASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELV 556
             S +   + RGH   +  + FSPD     ++S D ++R+W+ +   C   A     E+ 
Sbjct: 815 TDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVD 873

Query: 557 GVYTGQMSNVLSVQFMACNLLLVTGIT 583
            V+      VL+V  +   L L+ G T
Sbjct: 874 VVFQENEVMVLAVDHIR-RLQLINGRT 899



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 49/172 (28%), Positives = 75/172 (43%), Gaps = 2/172 (1%)

Query: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396
           ++R H   VY   F  D   + SC  D +++ +   +    +  + H   V     S   
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658

Query: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL--ATGSTDKTVRLWS 454
            + A+ S D+  ++W+      +  Y  H   V+C  F  +S++L  ATGS+D  ++LW 
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKEL 506
             Q        GH   V    FSP+ K LAS   D  LKLWD  S    K +
Sbjct: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSI 770



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 67/279 (24%), Positives = 113/279 (40%), Gaps = 25/279 (8%)

Query: 277  SPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMK 336
            SPD        D+  I+LW  +     S         +    D++ +E++    A   ++
Sbjct: 837  SPDGSSFLTSSDDQTIRLWETKKVCKNS------AVMLKQEVDVVFQENEVMVLAVDHIR 890

Query: 337  ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS---------FTNTVLYQG---HA 384
             L+   G      +L ++  +  C     ++Y   G            N  ++Q    H 
Sbjct: 891  RLQLINGRTGQIDYLTEAQ-VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 949

Query: 385  YPVWDLDISPYSLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
              VW +  +       S S D   ++W++  D+   LR   GH   V   +   NS  L+
Sbjct: 950  KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRLLS 1006

Query: 443  TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502
              S D TV++W+   GN  + F  H+G VLS   S +    +S   D+  K+W       
Sbjct: 1007 W-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1065

Query: 503  YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
              ELRGH   +    FS DS L+A+   +  +R+W++ N
Sbjct: 1066 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1104



 Score = 62.8 bits (151), Expect = 9e-10
 Identities = 68/312 (21%), Positives = 113/312 (36%), Gaps = 81/312 (25%)

Query: 282 LLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGH 341
           LLA G  +  +KLW L  K+ ++                                 + GH
Sbjct: 704 LLATGSSDCFLKLWDLNQKECRNT--------------------------------MFGH 731

Query: 342 CGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAY------PVWDLD-ISP 394
              V   RF  D   L SCS D +++ WD  S           +      P  D++ I  
Sbjct: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVK 791

Query: 395 YSLYFASGSHDRTAR-----LWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
              + A G+    A      LW+ D    +    GHL+ V  V F P+ +   T S D+T
Sbjct: 792 CCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 851

Query: 450 VRLWSAQ------------------QGNSV-----------RLFTGHRGPVLSLA----- 475
           +RLW  +                  Q N V           +L  G  G +  L      
Sbjct: 852 IRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVS 911

Query: 476 ---FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDN 532
               SP+ +Y+A   E+  +++ +L +  +++    H   +  + F+ D   + S+S D 
Sbjct: 912 CCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDA 971

Query: 533 SVRVWDIRNTYC 544
            ++VW+ +   C
Sbjct: 972 EIQVWNWQLDKC 983



 Score = 53.9 bits (128), Expect = 4e-07
 Identities = 34/117 (29%), Positives = 53/117 (45%), Gaps = 13/117 (11%)

Query: 467 HRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIA 526
           H   V    FS +G+ +AS G D+ L+++   +G    E++ H D +    FS D   IA
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662

Query: 527 SASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQF--MACNLLLVTG 581
           + S+D  V++W           +  + ELV  Y      V    F   + +LLL TG
Sbjct: 663 TCSVDKKVKIW-----------NSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATG 708


>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
            sapiens]
          Length = 1237

 Score =  103 bits (258), Expect = 3e-22
 Identities = 81/274 (29%), Positives = 125/274 (45%), Gaps = 20/274 (7%)

Query: 265  YNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSE--PHQVDVSRIHLACD--- 319
            Y TE  ++   +SP  + +A G +N  I++  L + ++      H+  V  I    D   
Sbjct: 947  YLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKT 1006

Query: 320  ILEEEDDEDDNAGT----EMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFT 375
            ++   DD +         +   LRGH   V   R L +S  LLS S D +++ W++ +  
Sbjct: 1007 LISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSR-LLSWSFDGTVKVWNIITGN 1065

Query: 376  NTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFH 435
                +  H   V   DIS  +  F+S S D+TA++WSFD   PL    GH   V C  F 
Sbjct: 1066 KEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFS 1125

Query: 436  PNSNYLATGSTDKTVRLWSAQQGNSVRL--------FTGHRGPVLSLAFSPNGKYLASAG 487
             +S  LATG  +  +R+W+   G  + L           H G V  L FSP+GK L SAG
Sbjct: 1126 VDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG 1185

Query: 488  EDQRLKLWDLASGTLYKELRGHTDNITSLTFSPD 521
                +K W++ +G   +    +  N+  +  SPD
Sbjct: 1186 --GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPD 1217



 Score = 79.3 bits (194), Expect = 9e-15
 Identities = 47/158 (29%), Positives = 75/158 (47%), Gaps = 2/158 (1%)

Query: 383 HAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
           H   V+    S      AS   D+T +++  +    L     H  +V C  F  +  ++A
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662

Query: 443 TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL--ASAGEDQRLKLWDLASG 500
           T S DK V++W++  G  V  +  H   V    F+ +  +L  A+   D  LKLWDL   
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQK 722

Query: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
                + GHT+++    FSPD  L+AS S D ++++WD
Sbjct: 723 ECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWD 760



 Score = 77.0 bits (188), Expect = 4e-14
 Identities = 66/263 (25%), Positives = 107/263 (40%), Gaps = 26/263 (9%)

Query: 337 ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYS 396
           ++R H   VY   F  D   + SC  D +++ +   +    +  + H   V     S   
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDD 658

Query: 397 LYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYL--ATGSTDKTVRLWS 454
            + A+ S D+  ++W+      +  Y  H   V+C  F  +S++L  ATGS+D  ++LW 
Sbjct: 659 RFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWD 718

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGT---------LYKE 505
             Q        GH   V    FSP+ K LAS   D  LKLWD  S            +  
Sbjct: 719 LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLN 778

Query: 506 LRGHTDN----ITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTG 561
           L    ++    +   ++S D   I  A+  N + ++DI           +S  L  ++TG
Sbjct: 779 LEDPQEDMEVIVKCCSWSADGARIMVAA-KNKIFLFDIH----------TSGLLGEIHTG 827

Query: 562 QMSNVLSVQFMACNLLLVTGITQ 584
             S +    F   N L V  ++Q
Sbjct: 828 HHSTIQYCDFSPQNHLAVVALSQ 850



 Score = 73.9 bits (180), Expect = 4e-13
 Identities = 67/279 (24%), Positives = 113/279 (40%), Gaps = 25/279 (8%)

Query: 277  SPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMK 336
            SPD        D+  I+LW  +     S         +    D++ +E++    A   ++
Sbjct: 880  SPDGSSFLTSSDDQTIRLWETKKVCKNS------AVMLKQEVDVVFQENEVMVLAVDHIR 933

Query: 337  ILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS---------FTNTVLYQG---HA 384
             L+   G      +L ++  +  C     ++Y   G            N  ++Q    H 
Sbjct: 934  RLQLINGRTGQIDYLTEAQ-VSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHK 992

Query: 385  YPVWDLDISPYSLYFASGSHDRTARLWSF--DRTYPLRIYAGHLADVDCVKFHPNSNYLA 442
              VW +  +       S S D   ++W++  D+   LR   GH   V   +   NS  L+
Sbjct: 993  KTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLR---GHQETVKDFRLLKNSRLLS 1049

Query: 443  TGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTL 502
              S D TV++W+   GN  + F  H+G VLS   S +    +S   D+  K+W       
Sbjct: 1050 W-SFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLP 1108

Query: 503  YKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
              ELRGH   +    FS DS L+A+   +  +R+W++ N
Sbjct: 1109 LHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSN 1147



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 68/309 (22%), Positives = 111/309 (35%), Gaps = 59/309 (19%)

Query: 332 GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPV--WD 389
           G ++  ++ H   V    F  D   + +CS D  ++ W+  +      Y  H+  V    
Sbjct: 636 GEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCH 695

Query: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
              S + L  A+GS D   +LW  ++        GH   V+  +F P+   LA+ S D T
Sbjct: 696 FTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGT 755

Query: 450 VRLWSAQQG-------------------------------------------NSVRLF-- 464
           ++LW A                                              N + LF  
Sbjct: 756 LKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDI 815

Query: 465 ----------TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
                     TGH   +    FSP       A     ++LW+  S +   + RGH   + 
Sbjct: 816 HTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVH 875

Query: 515 SLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMAC 574
            + FSPD     ++S D ++R+W+ +   C   A     E+  V+      VL+V  +  
Sbjct: 876 GVMFSPDGSSFLTSSDDQTIRLWETKKV-CKNSAVMLKQEVDVVFQENEVMVLAVDHIR- 933

Query: 575 NLLLVTGIT 583
            L L+ G T
Sbjct: 934 RLQLINGRT 942



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 68/322 (21%), Positives = 125/322 (38%), Gaps = 56/322 (17%)

Query: 260  CFYAFYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACD 319
            C    +     +N    SPD KLLA+   +  +KLW   S    +E   ++V +      
Sbjct: 724  CRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSA---NERKSINVKQF----- 775

Query: 320  ILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVL 379
             L  ED ++D     M+++   C       + AD + ++  +++    +    S     +
Sbjct: 776  FLNLEDPQED-----MEVIVKCCS------WSADGARIMVAAKNKIFLFDIHTSGLLGEI 824

Query: 380  YQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
            + GH   +   D SP +             LW+ D    +    GHL+ V  V F P+ +
Sbjct: 825  HTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGS 884

Query: 440  YLATGSTDKTVRLWSAQ------------------QGNSV-----------RLFTGHRGP 470
               T S D+T+RLW  +                  Q N V           +L  G  G 
Sbjct: 885  SFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQ 944

Query: 471  VLSLA--------FSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDS 522
            +  L          SP+ +Y+A   E+  +++ +L +  +++    H   +  + F+ D 
Sbjct: 945  IDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADE 1004

Query: 523  GLIASASMDNSVRVWDIRNTYC 544
              + S+S D  ++VW+ +   C
Sbjct: 1005 KTLISSSDDAEIQVWNWQLDKC 1026


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score =  103 bits (257), Expect = 4e-22
 Identities = 89/323 (27%), Positives = 133/323 (41%), Gaps = 66/323 (20%)

Query: 277 SPDSKLLAAGFDNSCIKLWSLRSKK---------------LKSEPHQVDVSRIHLACDIL 321
           SPD + LA+G  N  I LW   + K               L  EP   +    ++A    
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASS-- 222

Query: 322 EEEDDE----DDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL------ 371
             +D      D  AG   +IL GH   V   R+  D   L S S+D +I+ W        
Sbjct: 223 -SKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGL-LYSASQDRTIKVWRAHDGVLC 280

Query: 372 ------GSFTNTVLY-----------------------QGHAYPVWDLDISPYSLY---- 398
                 G + NT+                         QG    + +  +S Y+L     
Sbjct: 281 RTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQG 340

Query: 399 ---FASGSHDRTARLWS-FDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWS 454
                SGS D T  LWS  +   PL    GH A ++ V F P+S  +A+ S DK+++LW 
Sbjct: 341 PERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWD 400

Query: 455 AQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNIT 514
            + G  +    GH   V  +A+S + + L S   D  LK+WD+ +  L  +L GH D + 
Sbjct: 401 GRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVY 460

Query: 515 SLTFSPDSGLIASASMDNSVRVW 537
           ++ +SPD   +AS   D  +R+W
Sbjct: 461 AVDWSPDGQRVASGGKDKCLRIW 483



 Score = 92.8 bits (229), Expect = 8e-19
 Identities = 53/163 (32%), Positives = 82/163 (50%), Gaps = 7/163 (4%)

Query: 381 QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNY 440
           +GH+  V  +  SP   Y ASGS D T R W      P     GH   V  + + P+   
Sbjct: 111 EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRK 170

Query: 441 LATGSTDKTVRLWSAQQGNSV-RLFTGHRGPVLSLAF-----SPNGKYLASAGEDQRLKL 494
           LA+G  +  + LW    G  V R   GH   +  L++     +P  +Y+AS+ +D  +++
Sbjct: 171 LASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRI 230

Query: 495 WDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVW 537
           WD  +G   + L GHT ++T L +  D GL+ SAS D +++VW
Sbjct: 231 WDTTAGRCERILTGHTQSVTCLRWGGD-GLLYSASQDRTIKVW 272



 Score = 88.2 bits (217), Expect = 2e-17
 Identities = 60/197 (30%), Positives = 89/197 (45%), Gaps = 7/197 (3%)

Query: 338 LRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSL 397
           L GH   V S  F      L S S D ++R+WDL + T     +GH + V  +  SP   
Sbjct: 110 LEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGR 169

Query: 398 YFASGSHDRTARLWSFDRTYPL-RIYAGHLADVDCVKF-----HPNSNYLATGSTDKTVR 451
             ASG  +    LW       + R  AGH   +  + +     +P   Y+A+ S D +VR
Sbjct: 170 KLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVR 229

Query: 452 LWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTD 511
           +W    G   R+ TGH   V  L +  +G  L SA +D+ +K+W    G L + L+GH  
Sbjct: 230 IWDTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAHDGVLCRTLQGHGH 288

Query: 512 NITSLTFSPDSGLIASA 528
            + ++  S D  L   A
Sbjct: 289 WVNTMALSTDYALRTGA 305



 Score = 84.0 bits (206), Expect = 4e-16
 Identities = 50/138 (36%), Positives = 74/138 (53%), Gaps = 6/138 (4%)

Query: 424 GHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYL 483
           GH   V  V F P   YLA+GS D TVR W            GHR  VLS+++SP+G+ L
Sbjct: 112 GHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISWSPDGRKL 171

Query: 484 ASAGEDQRLKLWDLASG-TLYKELRGHTDNITSLTF-----SPDSGLIASASMDNSVRVW 537
           AS  ++ ++ LWD ++G  + + L GH+  IT L++     +P+   +AS+S D SVR+W
Sbjct: 172 ASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIW 231

Query: 538 DIRNTYCSAPADGSSSEL 555
           D     C     G +  +
Sbjct: 232 DTTAGRCERILTGHTQSV 249



 Score = 80.1 bits (196), Expect = 5e-15
 Identities = 93/406 (22%), Positives = 152/406 (37%), Gaps = 102/406 (25%)

Query: 228 MPSPILQNEAALEVLQE--SIKRVKDGPPSLTTICFYAFYNTEQLLNTAEISPDSKLLAA 285
           + S  ++ E  L+++ +  +I RV+       T C  +     + + +   SP  K LA+
Sbjct: 77  LESQAVETEKVLDIIYQPQAIFRVR-----AVTRCTSSLEGHSEAVISVAFSPTGKYLAS 131

Query: 286 GFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPV 345
           G  ++ ++ W L ++              H  C                    +GH   V
Sbjct: 132 GSGDTTVRFWDLSTE------------TPHFTC--------------------KGHRHWV 159

Query: 346 YSTRFLADSSGLLSCSEDMSIRYWD--LGSFTNTVLYQGHAYPV----WD-LDISPYSLY 398
            S  +  D   L S  ++  I  WD   G      L  GH+  +    W+ L  +P   Y
Sbjct: 160 LSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTL-AGHSKWITGLSWEPLHANPECRY 218

Query: 399 FASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQG 458
            AS S D + R+W        RI  GH   V C+++      L + S D+T+++W A  G
Sbjct: 219 VASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRW-GGDGLLYSASQDRTIKVWRAHDG 277

Query: 459 NSVRLFTGHRGPVLSLAFSPN--------------------------------GKY---- 482
              R   GH   V ++A S +                                 +Y    
Sbjct: 278 VLCRTLQGHGHWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVR 337

Query: 483 ------LASAGEDQRLKLWDLASGTL-YKELRGHTDNITSLTFSPDSGLIASASMDNSVR 535
                 L S  +D  L LW  A        + GH   I  + FSPDS ++ASAS D S++
Sbjct: 338 GQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIK 397

Query: 536 VWDIRNTYCSAPADGSSSELVGVYTGQMSNVLSVQFMACNLLLVTG 581
           +W           DG + + +    G ++ V  + + A + LLV+G
Sbjct: 398 LW-----------DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSG 432



 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 62/239 (25%), Positives = 96/239 (40%), Gaps = 48/239 (20%)

Query: 187 LCKVLTLHIHLDVQPAKRTDYQLYASGSSSRSENNGLEPPDMPSPILQ-NEAALE----V 241
           LC+ L  H H     A  TDY L  +G+   +E + + P D+   + +  E AL     V
Sbjct: 279 LCRTLQGHGHWVNTMALSTDYAL-RTGAFEPAEAS-VNPQDLQGSLQELKERALSRYNLV 336

Query: 242 LQESIKRVKDGPPSLTTICFYAFYNT---------EQLLNTAEISPDSKLLAAGFDNSCI 292
             +  +R+  G    T   +    +          + L+N    SPDS+++A+   +  I
Sbjct: 337 RGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSI 396

Query: 293 KLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDNAGTEMKILRGHCGPVYSTRFLA 352
           KLW                                D   G  +  LRGH   VY   + A
Sbjct: 397 KLW--------------------------------DGRTGKYLASLRGHVAAVYQIAWSA 424

Query: 353 DSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLW 411
           DS  L+S S D +++ WD+ +    +   GHA  V+ +D SP     ASG  D+  R+W
Sbjct: 425 DSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483


>gi|19913367 transducin beta-like 1Y [Homo sapiens]
          Length = 522

 Score =  103 bits (256), Expect = 6e-22
 Identities = 77/297 (25%), Positives = 131/297 (44%), Gaps = 33/297 (11%)

Query: 277 SPDSKLLAAGFDNSCIKLWSLRSKK------------LKSEPHQV----DVSRIHLACD- 319
           +P S LLA+G  +S  ++W+L                ++   H V    DV+ +    D 
Sbjct: 188 NPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDG 247

Query: 320 ILEEEDDEDDNA------GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGS 373
            L      D  A      G     L  H GP+++ ++    + +LS   D +   WD  +
Sbjct: 248 TLLAMGSYDGFARIWTENGNLASTLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHT 307

Query: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVK 433
                 +  H+ P  D+D    ++ FAS S D    +      +P++ + GH  +V+ +K
Sbjct: 308 GEAKQQFPFHSAPALDVDWQN-NMTFASCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIK 366

Query: 434 FHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK---------YLA 484
           + P+   LA+ S D T+++WS +Q   V     H   + ++ +SP G           LA
Sbjct: 367 WDPSGMLLASCSDDMTLKIWSMKQDACVHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLA 426

Query: 485 SAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
           SA  D  ++LWD+  G     L  H + + S+ FSPD   +AS S D  V +W+ ++
Sbjct: 427 SASFDSTVRLWDVEQGVCTHTLMKHQEPVYSVAFSPDGKYLASGSFDKYVHIWNTQS 483



 Score = 99.8 bits (247), Expect = 6e-21
 Identities = 62/190 (32%), Positives = 93/190 (48%), Gaps = 10/190 (5%)

Query: 359 SCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYP 418
           SCS DM I    LG       +QGH   V  +   P  +  AS S D T ++WS  +   
Sbjct: 334 SCSTDMCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDAC 393

Query: 419 LRIYAGHLADVDCVKFHP---------NSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRG 469
           +     H  ++  +K+ P         +S  LA+ S D TVRLW  +QG        H+ 
Sbjct: 394 VHDLQAHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQE 453

Query: 470 PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASAS 529
           PV S+AFSP+GKYLAS   D+ + +W+  SG+L    +G T  I  + ++     + +++
Sbjct: 454 PVYSVAFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG-TGGIFEVCWNARGDKVGASA 512

Query: 530 MDNSVRVWDI 539
            D SV V D+
Sbjct: 513 SDGSVCVLDL 522



 Score = 89.4 bits (220), Expect = 9e-18
 Identities = 72/287 (25%), Positives = 115/287 (40%), Gaps = 65/287 (22%)

Query: 323 EEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL-----GSFTNT 377
           E D + +    +  +LRGH   V+   +   S  L S S D + R W+L     G  T  
Sbjct: 160 EIDGDVEIPPNKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQL 219

Query: 378 VLYQ-----GHAYP----VWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD 428
           VL       GH  P    V  LD +      A GS+D  AR+W+ +      +   H   
Sbjct: 220 VLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLASTL-GQHKGP 278

Query: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNS---------------------------- 460
           +  +K++   NY+ +   DKT  +W A  G +                            
Sbjct: 279 IFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTD 338

Query: 461 -------------VRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELR 507
                        V+ F GH   V ++ + P+G  LAS  +D  LK+W +       +L+
Sbjct: 339 MCIHVCRLGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQDACVHDLQ 398

Query: 508 GHTDNITSLTFSP---------DSGLIASASMDNSVRVWDIRNTYCS 545
            H+  I ++ +SP          S ++ASAS D++VR+WD+    C+
Sbjct: 399 AHSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQGVCT 445



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 39/154 (25%), Positives = 58/154 (37%), Gaps = 23/154 (14%)

Query: 271 LNTAEISPDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIHLACDILEEEDDEDDN 330
           +N  +  P   LLA+  D+  +K+WS++                  AC       D   +
Sbjct: 362 VNAIKWDPSGMLLASCSDDMTLKIWSMKQD----------------AC-----VHDLQAH 400

Query: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDL 390
           +     I     GP  S      S  L S S D ++R WD+     T     H  PV+ +
Sbjct: 401 SKEIYTIKWSPTGPATSNP--NSSIMLASASFDSTVRLWDVEQGVCTHTLMKHQEPVYSV 458

Query: 391 DISPYSLYFASGSHDRTARLWSFDRTYPLRIYAG 424
             SP   Y ASGS D+   +W+      +  Y G
Sbjct: 459 AFSPDGKYLASGSFDKYVHIWNTQSGSLVHSYQG 492


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.132    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,939,070
Number of Sequences: 37866
Number of extensions: 964367
Number of successful extensions: 6305
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 275
Number of HSP's successfully gapped in prelim test: 72
Number of HSP's that attempted gapping in prelim test: 2659
Number of HSP's gapped (non-prelim): 1820
length of query: 589
length of database: 18,247,518
effective HSP length: 108
effective length of query: 481
effective length of database: 14,157,990
effective search space: 6809993190
effective search space used: 6809993190
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.