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Search of human proteins with 75709217
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|75709217 cleavage stimulation factor subunit 1 [Homo
sapiens]
(431 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|75709220 cleavage stimulation factor subunit 1 [Homo sapiens] 880 0.0
gi|4557491 cleavage stimulation factor subunit 1 [Homo sapiens] 880 0.0
gi|75709217 cleavage stimulation factor subunit 1 [Homo sapiens] 880 0.0
gi|23199987 WD repeat domain 5B [Homo sapiens] 104 2e-22
gi|32189425 WD repeat domain 69 [Homo sapiens] 96 8e-20
gi|16554629 WD repeat domain 5 [Homo sapiens] 95 1e-19
gi|16554627 WD repeat domain 5 [Homo sapiens] 95 1e-19
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 85 1e-16
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 85 1e-16
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 85 1e-16
gi|26665869 WD repeat domain 51B [Homo sapiens] 84 2e-16
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 81 2e-15
gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Hom... 79 1e-14
gi|21071067 TBP-associated factor 5 [Homo sapiens] 75 1e-13
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 73 6e-13
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 73 6e-13
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 73 6e-13
gi|113865883 WD repeat domain 38 [Homo sapiens] 73 6e-13
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 73 6e-13
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 73 6e-13
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 72 7e-13
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 71 2e-12
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 70 4e-12
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 69 6e-12
gi|38327642 WD repeat domain 55 [Homo sapiens] 67 2e-11
gi|89886480 zinedin isoform 2 [Homo sapiens] 67 3e-11
gi|89886477 zinedin isoform 1 [Homo sapiens] 67 3e-11
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 66 5e-11
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 66 7e-11
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 66 7e-11
>gi|75709220 cleavage stimulation factor subunit 1 [Homo sapiens]
Length = 431
Score = 880 bits (2273), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMEN 60
MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMEN
Sbjct: 1 MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMEN 60
Query: 61 DDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDG 120
DDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDG
Sbjct: 61 DDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDG 120
Query: 121 QLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLA 180
QLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLA
Sbjct: 121 QLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLA 180
Query: 181 FHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPT 240
FHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPT
Sbjct: 181 FHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPT 240
Query: 241 LRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTF 300
LRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTF
Sbjct: 241 LRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTF 300
Query: 301 EKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAV 360
EKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAV
Sbjct: 301 EKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAV 360
Query: 361 FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR 420
FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR
Sbjct: 361 FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR 420
Query: 421 ARFWYRRSTTD 431
ARFWYRRSTTD
Sbjct: 421 ARFWYRRSTTD 431
>gi|4557491 cleavage stimulation factor subunit 1 [Homo sapiens]
Length = 431
Score = 880 bits (2273), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMEN 60
MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMEN
Sbjct: 1 MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMEN 60
Query: 61 DDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDG 120
DDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDG
Sbjct: 61 DDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDG 120
Query: 121 QLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLA 180
QLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLA
Sbjct: 121 QLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLA 180
Query: 181 FHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPT 240
FHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPT
Sbjct: 181 FHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPT 240
Query: 241 LRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTF 300
LRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTF
Sbjct: 241 LRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTF 300
Query: 301 EKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAV 360
EKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAV
Sbjct: 301 EKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAV 360
Query: 361 FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR 420
FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR
Sbjct: 361 FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR 420
Query: 421 ARFWYRRSTTD 431
ARFWYRRSTTD
Sbjct: 421 ARFWYRRSTTD 431
>gi|75709217 cleavage stimulation factor subunit 1 [Homo sapiens]
Length = 431
Score = 880 bits (2273), Expect = 0.0
Identities = 431/431 (100%), Positives = 431/431 (100%)
Query: 1 MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMEN 60
MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMEN
Sbjct: 1 MYRTKVGLKDRQQLYKLIISQLLYDGYISIANGLINEIKPQSVCAPSEQLLHLIKLGMEN 60
Query: 61 DDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDG 120
DDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDG
Sbjct: 61 DDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDG 120
Query: 121 QLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLA 180
QLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLA
Sbjct: 121 QLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLA 180
Query: 181 FHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPT 240
FHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPT
Sbjct: 181 FHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPT 240
Query: 241 LRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTF 300
LRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTF
Sbjct: 241 LRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTF 300
Query: 301 EKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAV 360
EKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAV
Sbjct: 301 EKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAV 360
Query: 361 FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR 420
FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR
Sbjct: 361 FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR 420
Query: 421 ARFWYRRSTTD 431
ARFWYRRSTTD
Sbjct: 421 ARFWYRRSTTD 431
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 104 bits (259), Expect = 2e-22
Identities = 70/242 (28%), Positives = 119/242 (49%), Gaps = 10/242 (4%)
Query: 167 RTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFH 226
+TLY H E++ +A+ L S S D TLKL+D + K + + +F+
Sbjct: 77 KTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLK--GHSNYVFCCNFN 134
Query: 227 PSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCI 286
P + I+ G+ T++++++ T +C + + H+D + +V++N S ++ V+GS DG
Sbjct: 135 PPSNLIISGSFDETVKIWEVKTGKCLKTLSA---HSDPVSAVHFNCSGSLIVSGSYDGLC 191
Query: 287 KLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTG 346
++WD S +C+ T D V FS N KYIL++ D+ KLW+ S GR L YTG
Sbjct: 192 RIWDAASGQCLKTLVD-DDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTG 250
Query: 347 AGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHS 406
+ + A F+ T ++ + W+ +T E L GH ++V
Sbjct: 251 ---HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-GHTDVVISAACH 306
Query: 407 PT 408
PT
Sbjct: 307 PT 308
Score = 73.6 bits (179), Expect = 3e-13
Identities = 62/275 (22%), Positives = 120/275 (43%), Gaps = 27/275 (9%)
Query: 94 PEASEYET-CYVTSHKGPCRVATYSRDGQLIATGSADASIKILDT-----ERML------ 141
PE Y C + H +S +G+ +A+ SAD I I E+ L
Sbjct: 26 PENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLE 85
Query: 142 -------AKSAMPIEVMMNETAQQ-NMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSR 193
+ S+ + ++T + ++ + ++TL H + V C F+P ++ SGS
Sbjct: 86 ISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSF 145
Query: 194 DYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFV 253
D T+K+++ + ++ + ++ F+ SG I+ G+ R++D + QC
Sbjct: 146 DETVKIWEVKTGKCLKTLS--AHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLK 203
Query: 254 SCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVC-SA 312
+ D + V ++ + +T + D +KLWD RC+ T+ H + C A
Sbjct: 204 TL--VDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTY-TGHKNEKYCIFA 260
Query: 313 IFS-KNSKYILSSGKDSVAKLWEISTGRTLVRYTG 346
FS K+I+S +D++ +W + T + + G
Sbjct: 261 NFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQG 295
Score = 36.6 bits (83), Expect = 0.045
Identities = 31/116 (26%), Positives = 50/116 (43%), Gaps = 7/116 (6%)
Query: 309 VCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYV 368
V S FS N +++ SS D + +W G+ G L V A + + V
Sbjct: 44 VSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDV----AWSSDSSRLV 99
Query: 369 LLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
D++T+ L WD R+ + L GH+N V C +P + ++ S D + W
Sbjct: 100 SASDDKTLKL--WDVRSGKCLKTLK-GHSNYVFCCNFNPPSNLIISGSFDETVKIW 152
Score = 34.3 bits (77), Expect = 0.22
Identities = 16/44 (36%), Positives = 26/44 (59%), Gaps = 2/44 (4%)
Query: 159 NMENHPVIRTLYDHVDEVTCLAFHPTEQILASGS--RDYTLKLF 200
N++ +++ L H D V A HPTE ++AS + D T+KL+
Sbjct: 283 NLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 95.5 bits (236), Expect = 8e-20
Identities = 78/306 (25%), Positives = 137/306 (44%), Gaps = 39/306 (12%)
Query: 120 GQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCL 179
G IATGS D + K+ ++E T H E+ CL
Sbjct: 147 GDKIATGSFDKTCKLW-----------------------SVETGKCYHTFRGHTAEIVCL 183
Query: 180 AFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHP 239
+F+P ++A+GS D T KL+D + + + + + S+SF+ SGD I+ G+
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWDIQ--NGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDH 241
Query: 240 TLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITT 299
T+ ++D +T + N H I S ++N ++ +TGS D KLWD + +C+ T
Sbjct: 242 TVVVWDADTGR---KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCVAT 298
Query: 300 FEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQA 359
HD E+ + F K I ++ D A+++ +T + + A L G + ++
Sbjct: 299 L-TGHDD-EILDSCFDYTGKLIATASADGTARIFSAATRKCI-----AKLEGHEGEISKI 351
Query: 360 VFNHTEDYVLL-PDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDD 418
FN +++L ++T + WD++T + +L + I C + N +T S D
Sbjct: 352 SFNPQGNHLLTGSSDKTARI--WDAQTGQCLQVLEGHTDEIFSCAFNYKGNI-VITGSKD 408
Query: 419 FRARFW 424
R W
Sbjct: 409 NTCRIW 414
Score = 80.5 bits (197), Expect = 3e-15
Identities = 66/287 (22%), Positives = 120/287 (41%), Gaps = 40/287 (13%)
Query: 57 GMENDDTAVQYAIGRSDTVAPGTGIDLEFDADVQTMSPEASEYETCYVT--SHKGPCRVA 114
G N A+ + D +A G+ FD + S E + CY T H
Sbjct: 132 GHRNVVYAIAFNNPYGDKIATGS-----FDKTCKLWSVETGK---CYHTFRGHTAEIVCL 183
Query: 115 TYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVD 174
+++ L+ATGS D + K+ D ++N + TL H
Sbjct: 184 SFNPQSTLVATGSMDTTAKLWD-----------------------IQNGEEVYTLRGHSA 220
Query: 175 EVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILV 234
E+ L+F+ + + +GS D+T+ ++D + ++ I + S SF+ IL
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWD--ADTGRKVNILIGHCAEISSASFNWDCSLILT 278
Query: 235 GTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSN 294
G+ T +L+D +C + H D I ++ + + T S DG +++ +
Sbjct: 279 GSMDKTCKLWDATNGKCVATLT---GHDDEILDSCFDYTGKLIATASADGTARIFSAATR 335
Query: 295 RCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTL 341
+CI E H+G E+ F+ ++L+ D A++W+ TG+ L
Sbjct: 336 KCIAKLE-GHEG-EISKISFNPQGNHLLTGSSDKTARIWDAQTGQCL 380
Score = 70.1 bits (170), Expect = 4e-12
Identities = 72/319 (22%), Positives = 130/319 (40%), Gaps = 55/319 (17%)
Query: 148 IEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSA 207
I+ + + Q + + + L H+ +T +A + + +GS D T KL+D + S
Sbjct: 67 IQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTA--SG 124
Query: 208 KRAFKYIQEAEMLRSISF-HPSGDFILVGTQHPTLRLYDINTFQCF------------VS 254
+ ++ +I+F +P GD I G+ T +L+ + T +C+ +S
Sbjct: 125 EELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLS 184
Query: 255 CNPQDQ---------------------------HTDAICSVNYNSSANMYVTGSKDGCIK 287
NPQ H+ I S+++N+S + +TGS D +
Sbjct: 185 FNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVV 244
Query: 288 LWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGA 347
+WD + R + AE+ SA F+ + IL+ D KLW+ + G+ + A
Sbjct: 245 VWDADTGRKVNIL--IGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNGKCV-----A 297
Query: 348 GLSGRQVHRTQAVFNHTEDYVLLPD-ERTISLCCWDSRTAERRNLLSL-GHNNIVRCIVH 405
L+G + F++T + + T + A R+ + L GH + I
Sbjct: 298 TLTGHDDEILDSCFDYTGKLIATASADGTARI----FSAATRKCIAKLEGHEGEISKISF 353
Query: 406 SPTNPGFMTCSDDFRARFW 424
+P +T S D AR W
Sbjct: 354 NPQGNHLLTGSSDKTARIW 372
Score = 38.9 bits (89), Expect = 0.009
Identities = 31/143 (21%), Positives = 61/143 (42%), Gaps = 29/143 (20%)
Query: 104 VTSHKGPCRVATYSRDGQLIATGSADASIKILD--TERMLAKSAMPIEVMMNETAQQNME 161
+T H + + G+LIAT SAD + +I T + +AK
Sbjct: 299 LTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK------------------ 340
Query: 162 NHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLR 221
L H E++ ++F+P L +GS D T +++D + + + +
Sbjct: 341 -------LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLE--GHTDEIF 391
Query: 222 SISFHPSGDFILVGTQHPTLRLY 244
S +F+ G+ ++ G++ T R++
Sbjct: 392 SCAFNYKGNIVITGSKDNTCRIW 414
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 95.1 bits (235), Expect = 1e-19
Identities = 65/242 (26%), Positives = 116/242 (47%), Gaps = 10/242 (4%)
Query: 167 RTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFH 226
+T+ H ++ +A+ +L S S D TLK++D S + K + + +F+
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFN 138
Query: 227 PSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCI 286
P + I+ G+ ++R++D+ T +C + H+D + +V++N ++ V+ S DG
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTL---PAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 287 KLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTG 346
++WD S +C+ T D V FS N KYIL++ D+ KLW+ S G+ L YTG
Sbjct: 196 RIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 347 AGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHS 406
+ + A F+ T ++ + W+ +T E L GH ++V
Sbjct: 255 ---HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-GHTDVVISTACH 310
Query: 407 PT 408
PT
Sbjct: 311 PT 312
Score = 68.9 bits (167), Expect = 8e-12
Identities = 50/245 (20%), Positives = 103/245 (42%), Gaps = 30/245 (12%)
Query: 104 VTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENH 163
++ HK +S D L+ + S D ++KI D + +
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD-----------------------VSSG 119
Query: 164 PVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSI 223
++TL H + V C F+P ++ SGS D +++++D + ++ + ++
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP--AHSDPVSAV 177
Query: 224 SFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKD 283
F+ G I+ + R++D + QC + D + V ++ + + + D
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--IDDDNPPVSFVKFSPNGKYILAATLD 235
Query: 284 GCIKLWDGVSNRCITTFEKAHDGAEVC-SAIFS-KNSKYILSSGKDSVAKLWEISTGRTL 341
+KLWD +C+ T+ H + C A FS K+I+S +D++ +W + T +
Sbjct: 236 NTLKLWDYSKGKCLKTY-TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Query: 342 VRYTG 346
+ G
Sbjct: 295 QKLQG 299
Score = 61.2 bits (147), Expect = 2e-09
Identities = 54/225 (24%), Positives = 92/225 (40%), Gaps = 19/225 (8%)
Query: 204 KPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRL---YDINTFQCFVSCNPQDQ 260
KP+ F + + S+ F P+G+++ + +++ YD F+ +S
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-GKFEKTIS-----G 85
Query: 261 HTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKY 320
H I V ++S +N+ V+ S D +K+WD S +C+ T K H C F+ S
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFC-CNFNPQSNL 143
Query: 321 ILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLC- 379
I+S D ++W++ TG+ L VH FN D L+ LC
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH-----FN--RDGSLIVSSSYDGLCR 196
Query: 380 CWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
WD+ + + L N V + SP + + D + W
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 35.0 bits (79), Expect = 0.13
Identities = 17/44 (38%), Positives = 26/44 (59%), Gaps = 2/44 (4%)
Query: 159 NMENHPVIRTLYDHVDEVTCLAFHPTEQILASGS--RDYTLKLF 200
N++ +++ L H D V A HPTE I+AS + D T+KL+
Sbjct: 287 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 95.1 bits (235), Expect = 1e-19
Identities = 65/242 (26%), Positives = 116/242 (47%), Gaps = 10/242 (4%)
Query: 167 RTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFH 226
+T+ H ++ +A+ +L S S D TLK++D S + K + + +F+
Sbjct: 81 KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLK--GHSNYVFCCNFN 138
Query: 227 PSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCI 286
P + I+ G+ ++R++D+ T +C + H+D + +V++N ++ V+ S DG
Sbjct: 139 PQSNLIVSGSFDESVRIWDVKTGKCLKTL---PAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 287 KLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTG 346
++WD S +C+ T D V FS N KYIL++ D+ KLW+ S G+ L YTG
Sbjct: 196 RIWDTASGQCLKTLID-DDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 347 AGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHS 406
+ + A F+ T ++ + W+ +T E L GH ++V
Sbjct: 255 ---HKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ-GHTDVVISTACH 310
Query: 407 PT 408
PT
Sbjct: 311 PT 312
Score = 68.9 bits (167), Expect = 8e-12
Identities = 50/245 (20%), Positives = 103/245 (42%), Gaps = 30/245 (12%)
Query: 104 VTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENH 163
++ HK +S D L+ + S D ++KI D + +
Sbjct: 83 ISGHKLGISDVAWSSDSNLLVSASDDKTLKIWD-----------------------VSSG 119
Query: 164 PVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSI 223
++TL H + V C F+P ++ SGS D +++++D + ++ + ++
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLP--AHSDPVSAV 177
Query: 224 SFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKD 283
F+ G I+ + R++D + QC + D + V ++ + + + D
Sbjct: 178 HFNRDGSLIVSSSYDGLCRIWDTASGQCLKTL--IDDDNPPVSFVKFSPNGKYILAATLD 235
Query: 284 GCIKLWDGVSNRCITTFEKAHDGAEVC-SAIFS-KNSKYILSSGKDSVAKLWEISTGRTL 341
+KLWD +C+ T+ H + C A FS K+I+S +D++ +W + T +
Sbjct: 236 NTLKLWDYSKGKCLKTY-TGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIV 294
Query: 342 VRYTG 346
+ G
Sbjct: 295 QKLQG 299
Score = 61.2 bits (147), Expect = 2e-09
Identities = 54/225 (24%), Positives = 92/225 (40%), Gaps = 19/225 (8%)
Query: 204 KPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRL---YDINTFQCFVSCNPQDQ 260
KP+ F + + S+ F P+G+++ + +++ YD F+ +S
Sbjct: 32 KPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYD-GKFEKTIS-----G 85
Query: 261 HTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKY 320
H I V ++S +N+ V+ S D +K+WD S +C+ T K H C F+ S
Sbjct: 86 HKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTL-KGHSNYVFC-CNFNPQSNL 143
Query: 321 ILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLC- 379
I+S D ++W++ TG+ L VH FN D L+ LC
Sbjct: 144 IVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVH-----FN--RDGSLIVSSSYDGLCR 196
Query: 380 CWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
WD+ + + L N V + SP + + D + W
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241
Score = 35.0 bits (79), Expect = 0.13
Identities = 17/44 (38%), Positives = 26/44 (59%), Gaps = 2/44 (4%)
Query: 159 NMENHPVIRTLYDHVDEVTCLAFHPTEQILASGS--RDYTLKLF 200
N++ +++ L H D V A HPTE I+AS + D T+KL+
Sbjct: 287 NLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/262 (24%), Positives = 110/262 (41%), Gaps = 29/262 (11%)
Query: 92 MSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKIL------DTERMLAKSA 145
M P++ Y T HK +S G L+A+GS D +++I ++ A +A
Sbjct: 10 MKPQSRAYR---FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTA 66
Query: 146 MPIEVMMNETAQQNM-------------ENHPVIRTLYDHVDEVTCLAFHPTEQILASGS 192
V Q + + +L H++ V C F P +++ S S
Sbjct: 67 TVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 126
Query: 193 RDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCF 252
D T+KL+D K S + Y + + + FHPSG I T++++D+ T +
Sbjct: 127 DDKTVKLWD--KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 184
Query: 253 VSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSA 312
H+ A+ ++++ S N +T S D +K+ D + R + T H G A
Sbjct: 185 ---QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLH-GHQGPATTVA 240
Query: 313 IFSKNSKYILSSGKDSVAKLWE 334
FS+ +Y S G D +W+
Sbjct: 241 -FSRTGEYFASGGSDEQVMVWK 261
Score = 77.4 bits (189), Expect = 2e-14
Identities = 48/186 (25%), Positives = 87/186 (46%), Gaps = 9/186 (4%)
Query: 172 HVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDF 231
H D VTC+ F P+ +LASGSRD T++++ + F+ +RS+ F G
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSVHFCSDGQS 79
Query: 232 ILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDG 291
+ + T++++ + + S + QH + + ++ + V+ S D +KLWD
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLS---QHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 136
Query: 292 VSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYT--GAGL 349
S C+ ++ G V F + I ++G D+ K+W++ T R L Y A +
Sbjct: 137 SSRECVHSY--CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 194
Query: 350 SGRQVH 355
+G H
Sbjct: 195 NGLSFH 200
Score = 53.1 bits (126), Expect = 5e-07
Identities = 38/147 (25%), Positives = 69/147 (46%), Gaps = 6/147 (4%)
Query: 202 YSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQH 261
+ KP + RA+++ + + ++F PSG + G++ T+R++ N H
Sbjct: 9 HMKPQS-RAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKG---ESTVFRAH 64
Query: 262 TDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYI 321
T + SV++ S +VT S D +K+W ++R F + V A FS + + I
Sbjct: 65 TATVRSVHFCSDGQSFVTASDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLI 122
Query: 322 LSSGKDSVAKLWEISTGRTLVRYTGAG 348
+S+ D KLW+ S+ + Y G
Sbjct: 123 VSASDDKTVKLWDKSSRECVHSYCEHG 149
Score = 38.9 bits (89), Expect = 0.009
Identities = 35/147 (23%), Positives = 58/147 (39%), Gaps = 11/147 (7%)
Query: 283 DGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLV 342
D C+ +W F H A C FS + + S +D ++W +
Sbjct: 2 DSCLMVWHMKPQSRAYRFT-GHKDAVTC-VNFSPSGHLLASGSRDKTVRIWVPNVKGEST 59
Query: 343 RYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLG-HNNIVR 401
+ + R VH + + +V D++T+ + W T ++ L SL H N VR
Sbjct: 60 VFRAHTATVRSVH----FCSDGQSFVTASDDKTVKV--W--ATHRQKFLFSLSQHINWVR 111
Query: 402 CIVHSPTNPGFMTCSDDFRARFWYRRS 428
C SP ++ SDD + W + S
Sbjct: 112 CAKFSPDGRLIVSASDDKTVKLWDKSS 138
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/262 (24%), Positives = 110/262 (41%), Gaps = 29/262 (11%)
Query: 92 MSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKIL------DTERMLAKSA 145
M P++ Y T HK +S G L+A+GS D +++I ++ A +A
Sbjct: 48 MKPQSRAYR---FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTA 104
Query: 146 MPIEVMMNETAQQNM-------------ENHPVIRTLYDHVDEVTCLAFHPTEQILASGS 192
V Q + + +L H++ V C F P +++ S S
Sbjct: 105 TVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164
Query: 193 RDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCF 252
D T+KL+D K S + Y + + + FHPSG I T++++D+ T +
Sbjct: 165 DDKTVKLWD--KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 222
Query: 253 VSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSA 312
H+ A+ ++++ S N +T S D +K+ D + R + T H G A
Sbjct: 223 ---QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLH-GHQGPATTVA 278
Query: 313 IFSKNSKYILSSGKDSVAKLWE 334
FS+ +Y S G D +W+
Sbjct: 279 -FSRTGEYFASGGSDEQVMVWK 299
Score = 77.4 bits (189), Expect = 2e-14
Identities = 48/186 (25%), Positives = 87/186 (46%), Gaps = 9/186 (4%)
Query: 172 HVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDF 231
H D VTC+ F P+ +LASGSRD T++++ + F+ +RS+ F G
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSVHFCSDGQS 117
Query: 232 ILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDG 291
+ + T++++ + + S + QH + + ++ + V+ S D +KLWD
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLS---QHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
Query: 292 VSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYT--GAGL 349
S C+ ++ G V F + I ++G D+ K+W++ T R L Y A +
Sbjct: 175 SSRECVHSY--CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 232
Query: 350 SGRQVH 355
+G H
Sbjct: 233 NGLSFH 238
Score = 70.1 bits (170), Expect = 4e-12
Identities = 53/188 (28%), Positives = 90/188 (47%), Gaps = 7/188 (3%)
Query: 161 ENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEML 220
E+ + R H D VTC+ F + LASGS D L ++ + KP + RA+++ + +
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW-HMKPQS-RAYRFTGHKDAV 64
Query: 221 RSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTG 280
++F PSG + G++ T+R++ N HT + SV++ S +VT
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKG---ESTVFRAHTATVRSVHFCSDGQSFVTA 121
Query: 281 SKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRT 340
S D +K+W ++R F + V A FS + + I+S+ D KLW+ S+
Sbjct: 122 SDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 341 LVRYTGAG 348
+ Y G
Sbjct: 180 VHSYCEHG 187
Score = 52.4 bits (124), Expect = 8e-07
Identities = 41/169 (24%), Positives = 70/169 (41%), Gaps = 11/169 (6%)
Query: 261 HTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKY 320
H DA+ V+++ + +GS D C+ +W F H A C FS +
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTC-VNFSPSGHL 75
Query: 321 ILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCC 380
+ S +D ++W + + + R VH + + +V D++T+ +
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH----FCSDGQSFVTASDDKTVKV-- 129
Query: 381 WDSRTAERRNLLSLG-HNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRS 428
W T ++ L SL H N VRC SP ++ SDD + W + S
Sbjct: 130 W--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 85.1 bits (209), Expect = 1e-16
Identities = 64/262 (24%), Positives = 110/262 (41%), Gaps = 29/262 (11%)
Query: 92 MSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKIL------DTERMLAKSA 145
M P++ Y T HK +S G L+A+GS D +++I ++ A +A
Sbjct: 48 MKPQSRAYR---FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTA 104
Query: 146 MPIEVMMNETAQQNM-------------ENHPVIRTLYDHVDEVTCLAFHPTEQILASGS 192
V Q + + +L H++ V C F P +++ S S
Sbjct: 105 TVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSAS 164
Query: 193 RDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCF 252
D T+KL+D K S + Y + + + FHPSG I T++++D+ T +
Sbjct: 165 DDKTVKLWD--KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLL 222
Query: 253 VSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSA 312
H+ A+ ++++ S N +T S D +K+ D + R + T H G A
Sbjct: 223 ---QHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLH-GHQGPATTVA 278
Query: 313 IFSKNSKYILSSGKDSVAKLWE 334
FS+ +Y S G D +W+
Sbjct: 279 -FSRTGEYFASGGSDEQVMVWK 299
Score = 77.4 bits (189), Expect = 2e-14
Identities = 48/186 (25%), Positives = 87/186 (46%), Gaps = 9/186 (4%)
Query: 172 HVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDF 231
H D VTC+ F P+ +LASGSRD T++++ + F+ +RS+ F G
Sbjct: 60 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSVHFCSDGQS 117
Query: 232 ILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDG 291
+ + T++++ + + S + QH + + ++ + V+ S D +KLWD
Sbjct: 118 FVTASDDKTVKVWATHRQKFLFSLS---QHINWVRCAKFSPDGRLIVSASDDKTVKLWDK 174
Query: 292 VSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYT--GAGL 349
S C+ ++ G V F + I ++G D+ K+W++ T R L Y A +
Sbjct: 175 SSRECVHSY--CEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAV 232
Query: 350 SGRQVH 355
+G H
Sbjct: 233 NGLSFH 238
Score = 70.1 bits (170), Expect = 4e-12
Identities = 53/188 (28%), Positives = 90/188 (47%), Gaps = 7/188 (3%)
Query: 161 ENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEML 220
E+ + R H D VTC+ F + LASGS D L ++ + KP + RA+++ + +
Sbjct: 7 EDPSLERHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVW-HMKPQS-RAYRFTGHKDAV 64
Query: 221 RSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTG 280
++F PSG + G++ T+R++ N HT + SV++ S +VT
Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWVPNVKG---ESTVFRAHTATVRSVHFCSDGQSFVTA 121
Query: 281 SKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRT 340
S D +K+W ++R F + V A FS + + I+S+ D KLW+ S+
Sbjct: 122 SDDKTVKVW--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSREC 179
Query: 341 LVRYTGAG 348
+ Y G
Sbjct: 180 VHSYCEHG 187
Score = 52.4 bits (124), Expect = 8e-07
Identities = 41/169 (24%), Positives = 70/169 (41%), Gaps = 11/169 (6%)
Query: 261 HTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKY 320
H DA+ V+++ + +GS D C+ +W F H A C FS +
Sbjct: 18 HRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRF-TGHKDAVTC-VNFSPSGHL 75
Query: 321 ILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCC 380
+ S +D ++W + + + R VH + + +V D++T+ +
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVH----FCSDGQSFVTASDDKTVKV-- 129
Query: 381 WDSRTAERRNLLSLG-HNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRS 428
W T ++ L SL H N VRC SP ++ SDD + W + S
Sbjct: 130 W--ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSS 176
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 84.0 bits (206), Expect = 2e-16
Identities = 59/228 (25%), Positives = 95/228 (41%), Gaps = 30/228 (13%)
Query: 106 SHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPV 165
+H P R +S DGQ +AT S D SIK+ +M
Sbjct: 100 AHTAPVRSVDFSADGQFLATASEDKSIKV-----------------------WSMYRQRF 136
Query: 166 IRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISF 225
+ +LY H V C F P +++ S S D T+K++D + F + F
Sbjct: 137 LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFS--DSVGFANFVDF 194
Query: 226 HPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGC 285
+PSG I T++++D+ + H+ + ++++ S N +T S DG
Sbjct: 195 NPSGTCIASAGSDQTVKVWDVRVNKLL---QHYQVHSGGVNCISFHPSGNYLITASSDGT 251
Query: 286 IKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLW 333
+K+ D + R I T + H G V + FSK + S G D+ LW
Sbjct: 252 LKILDLLEGRLIYTLQ-GHTG-PVFTVSFSKGGELFASGGADTQVLLW 297
Score = 73.6 bits (179), Expect = 3e-13
Identities = 55/242 (22%), Positives = 97/242 (40%), Gaps = 30/242 (12%)
Query: 103 YVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMEN 162
Y HK S +G+ +AT S D + + N +
Sbjct: 13 YFKGHKAAITSLDLSPNGKQLATASWDTFLMLW-----------------------NFKP 49
Query: 163 HPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRS 222
H H D VT + F P +LAS SRD T++L+ K FK +RS
Sbjct: 50 HARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGKFSEFK--AHTAPVRS 107
Query: 223 ISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSK 282
+ F G F+ ++ +++++ + + S +HT + ++ + V+ S+
Sbjct: 108 VDFSADGQFLATASEDKSIKVWSMYRQRFLYSLY---RHTHWVRCAKFSPDGRLIVSCSE 164
Query: 283 DGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLV 342
D IK+WD + +C+ F + A F+ + I S+G D K+W++ + L
Sbjct: 165 DKTIKIWDTTNKQCVNNFSDSVGFANFVD--FNPSGTCIASAGSDQTVKVWDVRVNKLLQ 222
Query: 343 RY 344
Y
Sbjct: 223 HY 224
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 81.3 bits (199), Expect = 2e-15
Identities = 70/313 (22%), Positives = 127/313 (40%), Gaps = 37/313 (11%)
Query: 141 LAKSAMPIEVMMNETAQQNMENHPVIR---------------TLYDHVDEVTCLAFHPTE 185
L K M +E +NE ++ P+ + L H VT + FHP
Sbjct: 61 LQKKVMELESKLNEAKEEFTSGGPLGQKRDPKEWIPRPPEKYALSGHRSPVTRVIFHPVF 120
Query: 186 QILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYD 245
++ S S D T+K++DY +R K + ++ ISF SG + + T++L+D
Sbjct: 121 SVMVSASEDATIKVWDYETGDFERTLK--GHTDSVQDISFDHSGKLLASCSADMTIKLWD 178
Query: 246 INTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHD 305
F+C + + D + + SV + + V+ S+D IK+W+ + C+ TF +
Sbjct: 179 FQGFECIRTMHGHDHN---VSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 306 GAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRT---------LVRYTGAGLSGRQVHR 356
+ +++ I S D ++W ++T +V
Sbjct: 236 WVRMVRP--NQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSI 293
Query: 357 TQAVFNHTEDY-----VLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPG 411
++A + T+ LL R ++ WD T L +GH+N VR ++
Sbjct: 294 SEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTL-VGHDNWVRGVLFHSGGKF 352
Query: 412 FMTCSDDFRARFW 424
++C+DD R W
Sbjct: 353 ILSCADDKTLRVW 365
Score = 73.6 bits (179), Expect = 3e-13
Identities = 73/340 (21%), Positives = 135/340 (39%), Gaps = 55/340 (16%)
Query: 104 VTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENH 163
++ H+ P + ++ + S DA+IK+ D E
Sbjct: 104 LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWD-----------------------YETG 140
Query: 164 PVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSI 223
RTL H D V ++F + ++LAS S D T+KL+D+ R + S+
Sbjct: 141 DFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMH--GHDHNVSSV 198
Query: 224 SFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKD 283
+ P+GD I+ ++ T++++++ T C + H + + V N + + S D
Sbjct: 199 AIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTG---HREWVRMVRPNQDGTLIASCSND 255
Query: 284 GCIKLWDGVSNRCITTFEKAHDGAEVCS------------AIFSKNSK------YILSSG 325
+++W + C + E S A S+ K ++LS
Sbjct: 256 QTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGS 315
Query: 326 KDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVL-LPDERTISLCCWDSR 384
+D K+W++STG L+ G R V +F+ ++L D++T+ + WD +
Sbjct: 316 RDKTIKMWDVSTGMCLMTLVGHDNWVRGV-----LFHSGGKFILSCADDKTLRV--WDYK 368
Query: 385 TAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
L+ H + V + T P +T S D + W
Sbjct: 369 NKRCMKTLN-AHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 65.5 bits (158), Expect = 9e-11
Identities = 50/189 (26%), Positives = 89/189 (47%), Gaps = 14/189 (7%)
Query: 105 TSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHP 164
T H+ R+ ++DG LIA+ S D ++++ ++A E+ +E + + P
Sbjct: 231 TGHREWVRMVRPNQDGTLIASCSNDQTVRVW----VVATKECKAELREHEHVVECISWAP 286
Query: 165 VIRTLYDHVDEVTCLAFHPTEQ---ILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLR 221
+ Y + E T + + L SGSRD T+K++D S + + +R
Sbjct: 287 --ESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVS--TGMCLMTLVGHDNWVR 342
Query: 222 SISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGS 281
+ FH G FIL TLR++D +C + N H + S++++ +A VTGS
Sbjct: 343 GVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNA---HEHFVTSLDFHKTAPYVVTGS 399
Query: 282 KDGCIKLWD 290
D +K+W+
Sbjct: 400 VDQTVKVWE 408
Score = 63.5 bits (153), Expect = 3e-10
Identities = 57/288 (19%), Positives = 126/288 (43%), Gaps = 47/288 (16%)
Query: 86 DADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTE------- 138
DA ++ E ++E + H + ++ G+L+A+ SAD +IK+ D +
Sbjct: 129 DATIKVWDYETGDFERT-LKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRT 187
Query: 139 ------RMLAKSAMP-----IEVMMNETAQQ-NMENHPVIRTLYDHVDEVTCLAFHPTEQ 186
+ + + MP + ++T + ++ ++T H + V + +
Sbjct: 188 MHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGT 247
Query: 187 ILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPS------------------ 228
++AS S D T++++ + K + + ++ IS+ P
Sbjct: 248 LIASCSNDQTVRVWVVATKECKAELR--EHEHVVECISWAPESSYSSISEATGSETKKSG 305
Query: 229 --GDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCI 286
G F+L G++ T++++D++T C ++ H + + V ++S ++ + D +
Sbjct: 306 KPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG---HDNWVRGVLFHSGGKFILSCADDKTL 362
Query: 287 KLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWE 334
++WD + RC+ T AH+ V S F K + Y+++ D K+WE
Sbjct: 363 RVWDYKNKRCMKTLN-AHEHF-VTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|7657381 PRP19/PSO4 pre-mRNA processing factor 19 homolog [Homo
sapiens]
Length = 504
Score = 78.6 bits (192), Expect = 1e-14
Identities = 49/200 (24%), Positives = 95/200 (47%), Gaps = 11/200 (5%)
Query: 136 DTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDY 195
DT ++L A V+ +++++Q ++ TL H +VT + FHP++ ++ S S D
Sbjct: 233 DTNKILTGGADKNVVVFDKSSEQ------ILATLKGHTKKVTSVVFHPSQDLVFSASPDA 286
Query: 196 TLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSC 255
T++++ S + + + A + +S H +GD++L + DI T +
Sbjct: 287 TIRIWSVPNASCVQVVRAHESA--VTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKV 344
Query: 256 NPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFS 315
+ C+ ++ ++ TG+ D IK+WD + F H G + S FS
Sbjct: 345 TDETSGCSLTCA-QFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP-GHSGP-ITSIAFS 401
Query: 316 KNSKYILSSGKDSVAKLWEI 335
+N Y+ ++ DS KLW++
Sbjct: 402 ENGYYLATAADDSSVKLWDL 421
Score = 53.5 bits (127), Expect = 4e-07
Identities = 48/198 (24%), Positives = 79/198 (39%), Gaps = 20/198 (10%)
Query: 232 ILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDG 291
IL G + ++D ++ Q + HT + SV ++ S ++ + S D I++W
Sbjct: 237 ILTGGADKNVVVFDKSSEQILATLKG---HTKKVTSVVFHPSQDLVFSASPDATIRIWSV 293
Query: 292 VSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYT----GA 347
+ C+ +AH+ A V Y+LSS D +I TGR L + T G
Sbjct: 294 PNASCVQVV-RAHESA-VTGLSLHATGDYLLSSSDDQYWAFSDIQTGRVLTKVTDETSGC 351
Query: 348 GLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSL-GHNNIVRCIVHS 406
L+ Q H +F + WD + ER N+ + GH+ + I S
Sbjct: 352 SLTCAQFHPDGLIFG--------TGTMDSQIKIWDLK--ERTNVANFPGHSGPITSIAFS 401
Query: 407 PTNPGFMTCSDDFRARFW 424
T +DD + W
Sbjct: 402 ENGYYLATAADDSSVKLW 419
Score = 40.4 bits (93), Expect = 0.003
Identities = 35/163 (21%), Positives = 69/163 (42%), Gaps = 14/163 (8%)
Query: 176 VTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVG 235
+TC FHP I +G+ D +K++D + + F + + SI+F +G ++
Sbjct: 353 LTCAQFHPDGLIFGTGTMDSQIKIWDLKERTNVANFP--GHSGPITSIAFSENGYYLATA 410
Query: 236 TQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCI---KLWDGV 292
+++L+D+ + F + Q + + S+ ++ S G D I K W +
Sbjct: 411 ADDSSVKLWDLRKLKNFKTL--QLDNNFEVKSLIFDQSGTYLALGGTDVQIYICKQWTEI 468
Query: 293 SNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEI 335
+ H G F ++K+I S+G D K + +
Sbjct: 469 LH------FTEHSGL-TTGVAFGHHAKFIASTGMDRSLKFYSL 504
Score = 38.1 bits (87), Expect = 0.016
Identities = 33/134 (24%), Positives = 56/134 (41%), Gaps = 26/134 (19%)
Query: 104 VTSHKGPCRV--ATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNME 161
VT C + A + DG + TG+ D+ IKI D + + N+
Sbjct: 344 VTDETSGCSLTCAQFHPDGLIFGTGTMDSQIKIWDLKE-----------------RTNVA 386
Query: 162 NHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLR 221
N P H +T +AF LA+ + D ++KL+D K + + E ++
Sbjct: 387 NFP------GHSGPITSIAFSENGYYLATAADDSSVKLWDLRKLKNFKTLQLDNNFE-VK 439
Query: 222 SISFHPSGDFILVG 235
S+ F SG ++ +G
Sbjct: 440 SLIFDQSGTYLALG 453
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 75.1 bits (183), Expect = 1e-13
Identities = 51/231 (22%), Positives = 95/231 (41%), Gaps = 24/231 (10%)
Query: 81 IDLEFDADVQTMSPEASEYETCYVTSHKGPCRVATYSRDGQLIATGSADASIKILDTERM 140
ID E D ++ + E + E + H GP A++S D + + S D ++++ +
Sbjct: 516 IDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTF 575
Query: 141 LA-------------KSAMPIEVMMNETAQQNM------ENHPVIRTLYDHVDEVTCLAF 181
P + +++ +R H+ +V C F
Sbjct: 576 TCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRF 635
Query: 182 HPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTL 241
HP +A+GS D T++L+D + R F + S++F P+G F+ G +
Sbjct: 636 HPNSNYVATGSADRTVRLWDVLNGNCVRIF--TGHKGPIHSLTFSPNGRFLATGATDGRV 693
Query: 242 RLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGV 292
L+DI + HTD +CS+ ++ + +GS D ++LWD +
Sbjct: 694 LLWDIGH---GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAI 741
Score = 62.4 bits (150), Expect = 8e-10
Identities = 54/231 (23%), Positives = 96/231 (41%), Gaps = 21/231 (9%)
Query: 119 DGQLIATGSADASIKILDTERMLAKSAMP------IEVMMNETAQQNMENHPV--IRTLY 170
D LIA G AD+++++ +S I+ ++ ++ M+ ++ LY
Sbjct: 481 DSSLIAGGFADSTVRVWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILY 540
Query: 171 DHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGD 230
H V +F P L S S D T++L+ + +K + F P G
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYK--GHNYPVWDTQFSPYGY 598
Query: 231 FILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVN---YNSSANMYVTGSKDGCIK 287
+ + G RL+ + +Q P + VN ++ ++N TGS D ++
Sbjct: 599 YFVSGGHDRVARLWATDHYQ------PLRIFAGHLADVNCTRFHPNSNYVATGSADRTVR 652
Query: 288 LWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTG 338
LWD ++ C+ F H G + S FS N +++ + D LW+I G
Sbjct: 653 LWDVLNGNCVRIF-TGHKG-PIHSLTFSPNGRFLATGATDGRVLLWDIGHG 701
Score = 52.4 bits (124), Expect = 8e-07
Identities = 31/123 (25%), Positives = 55/123 (44%), Gaps = 5/123 (4%)
Query: 224 SFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKD 283
SF P +++L ++ T+RL+ + TF C V H + ++ +V+G D
Sbjct: 550 SFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKG---HNYPVWDTQFSPYGYYFVSGGHD 606
Query: 284 GCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVR 343
+LW + + F A A+V F NS Y+ + D +LW++ G +
Sbjct: 607 RVARLWATDHYQPLRIF--AGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGNCVRI 664
Query: 344 YTG 346
+TG
Sbjct: 665 FTG 667
Score = 47.0 bits (110), Expect = 3e-05
Identities = 31/100 (31%), Positives = 44/100 (44%), Gaps = 23/100 (23%)
Query: 105 TSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHP 164
T HKGP T+S +G+ +ATG+ D + + D L
Sbjct: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGL----------------------- 702
Query: 165 VIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSK 204
++ L H D V L F +ILASGS D T++L+D K
Sbjct: 703 MVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIK 742
Score = 35.0 bits (79), Expect = 0.13
Identities = 18/43 (41%), Positives = 23/43 (53%), Gaps = 1/43 (2%)
Query: 304 HDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTG 346
H G V A FS + Y+LSS +D +LW + T LV Y G
Sbjct: 542 HSGP-VYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKG 583
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 72.8 bits (177), Expect = 6e-13
Identities = 66/238 (27%), Positives = 110/238 (46%), Gaps = 23/238 (9%)
Query: 159 NMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAE 218
N E I TLY H V C+ H E+ + SGSRD TL+++D +
Sbjct: 329 NAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVL--MGHVA 384
Query: 219 MLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYV 278
+R + + G ++ G ++++D T C + HT+ + S+ ++ V
Sbjct: 385 AVRCVQY--DGRRVVSGAYDFMVKVWDPETETCL---HTLQGHTNRVYSLQFDGI--HVV 437
Query: 279 TGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTG 338
+GS D I++WD + CI T G + ++ ++S DS K+W+I TG
Sbjct: 438 SGSLDTSIRVWDVETGNCIHTL----TGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG 493
Query: 339 RTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLL-PDERTISLCCWDSRTAE-RRNLLSL 394
+ L T G + Q T FN +++V+ D+ T+ L WD +T E RNL++L
Sbjct: 494 QCL--QTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKL--WDLKTGEFIRNLVTL 545
Score = 63.5 bits (153), Expect = 3e-10
Identities = 63/260 (24%), Positives = 111/260 (42%), Gaps = 25/260 (9%)
Query: 166 IRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISF 225
+RTL H V + I+ SGS D TLK+ ++ + + +R +
Sbjct: 296 LRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKV--WNAETGECIHTLYGHTSTVRCMHL 351
Query: 226 HPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGC 285
H ++ G++ TLR++DI T QC + H A+ V Y+ V+G+ D
Sbjct: 352 HEKR--VVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYD--GRRVVSGAYDFM 404
Query: 286 IKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYT 345
+K+WD + C+ T + H V S F + +++S D+ ++W++ TG + T
Sbjct: 405 VKVWDPETETCLHTLQ-GHTN-RVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT 460
Query: 346 GAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVH 405
G H++ +D +L+ ++ WD +T + L G N +
Sbjct: 461 G--------HQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQ-GPNKHQSAVTC 511
Query: 406 SPTNPGF-MTCSDDFRARFW 424
N F +T SDD + W
Sbjct: 512 LQFNKNFVITSSDDGTVKLW 531
Score = 58.2 bits (139), Expect = 1e-08
Identities = 58/230 (25%), Positives = 95/230 (41%), Gaps = 53/230 (23%)
Query: 107 HKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVI 166
H R Y DG+ + +G+ D +K+ D E ET +
Sbjct: 382 HVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE--------------TETC---------L 416
Query: 167 RTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFH 226
TL H + V L F + SGS D +++++D ++ + +++ H
Sbjct: 417 HTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWD------------VETGNCIHTLTGH 462
Query: 227 PS-------GDFILV-GTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYV 278
S D ILV G T++++DI T QC + ++H A+ + +N N +
Sbjct: 463 QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVI 520
Query: 279 TGSKDGCIKLWD---GVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSG 325
T S DG +KLWD G R + T E G V I + N+K + + G
Sbjct: 521 TSSDDGTVKLWDLKTGEFIRNLVTLESGGSGG-VVWRIRASNTKLVCAVG 569
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/150 (24%), Positives = 62/150 (41%), Gaps = 15/150 (10%)
Query: 275 NMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWE 334
N V+GS D +K+W V+ +C+ T H G S + I+S D K+W
Sbjct: 274 NRIVSGSDDNTLKVWSAVTGKCLRTL-VGHTGGVWSSQM---RDNIIISGSTDRTLKVWN 329
Query: 335 ISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSL 394
TG + G H + H + ++ R +L WD T + ++L +
Sbjct: 330 AETGECIHTLYG--------HTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVL-M 380
Query: 395 GHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
GH VRC+ + ++ + DF + W
Sbjct: 381 GHVAAVRCVQYDGRR--VVSGAYDFMVKVW 408
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 72.8 bits (177), Expect = 6e-13
Identities = 66/238 (27%), Positives = 110/238 (46%), Gaps = 23/238 (9%)
Query: 159 NMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAE 218
N E I TLY H V C+ H E+ + SGSRD TL+++D +
Sbjct: 447 NAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVL--MGHVA 502
Query: 219 MLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYV 278
+R + + G ++ G ++++D T C + HT+ + S+ ++ V
Sbjct: 503 AVRCVQY--DGRRVVSGAYDFMVKVWDPETETCL---HTLQGHTNRVYSLQFDGI--HVV 555
Query: 279 TGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTG 338
+GS D I++WD + CI T G + ++ ++S DS K+W+I TG
Sbjct: 556 SGSLDTSIRVWDVETGNCIHTL----TGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG 611
Query: 339 RTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLL-PDERTISLCCWDSRTAE-RRNLLSL 394
+ L T G + Q T FN +++V+ D+ T+ L WD +T E RNL++L
Sbjct: 612 QCL--QTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKL--WDLKTGEFIRNLVTL 663
Score = 63.5 bits (153), Expect = 3e-10
Identities = 63/260 (24%), Positives = 111/260 (42%), Gaps = 25/260 (9%)
Query: 166 IRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISF 225
+RTL H V + I+ SGS D TLK+ ++ + + +R +
Sbjct: 414 LRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKV--WNAETGECIHTLYGHTSTVRCMHL 469
Query: 226 HPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGC 285
H ++ G++ TLR++DI T QC + H A+ V Y+ V+G+ D
Sbjct: 470 HEKR--VVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYD--GRRVVSGAYDFM 522
Query: 286 IKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYT 345
+K+WD + C+ T + H V S F + +++S D+ ++W++ TG + T
Sbjct: 523 VKVWDPETETCLHTLQ-GHTN-RVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT 578
Query: 346 GAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVH 405
G H++ +D +L+ ++ WD +T + L G N +
Sbjct: 579 G--------HQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQ-GPNKHQSAVTC 629
Query: 406 SPTNPGF-MTCSDDFRARFW 424
N F +T SDD + W
Sbjct: 630 LQFNKNFVITSSDDGTVKLW 649
Score = 58.2 bits (139), Expect = 1e-08
Identities = 58/230 (25%), Positives = 95/230 (41%), Gaps = 53/230 (23%)
Query: 107 HKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVI 166
H R Y DG+ + +G+ D +K+ D E ET +
Sbjct: 500 HVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE--------------TETC---------L 534
Query: 167 RTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFH 226
TL H + V L F + SGS D +++++D ++ + +++ H
Sbjct: 535 HTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWD------------VETGNCIHTLTGH 580
Query: 227 PS-------GDFILV-GTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYV 278
S D ILV G T++++DI T QC + ++H A+ + +N N +
Sbjct: 581 QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVI 638
Query: 279 TGSKDGCIKLWD---GVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSG 325
T S DG +KLWD G R + T E G V I + N+K + + G
Sbjct: 639 TSSDDGTVKLWDLKTGEFIRNLVTLESGGSGG-VVWRIRASNTKLVCAVG 687
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/150 (24%), Positives = 62/150 (41%), Gaps = 15/150 (10%)
Query: 275 NMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWE 334
N V+GS D +K+W V+ +C+ T H G S + I+S D K+W
Sbjct: 392 NRIVSGSDDNTLKVWSAVTGKCLRTL-VGHTGGVWSSQM---RDNIIISGSTDRTLKVWN 447
Query: 335 ISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSL 394
TG + G H + H + ++ R +L WD T + ++L +
Sbjct: 448 AETGECIHTLYG--------HTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVL-M 498
Query: 395 GHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
GH VRC+ + ++ + DF + W
Sbjct: 499 GHVAAVRCVQYDGRR--VVSGAYDFMVKVW 526
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 72.8 bits (177), Expect = 6e-13
Identities = 66/238 (27%), Positives = 110/238 (46%), Gaps = 23/238 (9%)
Query: 159 NMENHPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAE 218
N E I TLY H V C+ H E+ + SGSRD TL+++D +
Sbjct: 367 NAETGECIHTLYGHTSTVRCMHLH--EKRVVSGSRDATLRVWDIETGQCLHVL--MGHVA 422
Query: 219 MLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYV 278
+R + + G ++ G ++++D T C + HT+ + S+ ++ V
Sbjct: 423 AVRCVQY--DGRRVVSGAYDFMVKVWDPETETCL---HTLQGHTNRVYSLQFDGI--HVV 475
Query: 279 TGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTG 338
+GS D I++WD + CI T G + ++ ++S DS K+W+I TG
Sbjct: 476 SGSLDTSIRVWDVETGNCIHTL----TGHQSLTSGMELKDNILVSGNADSTVKIWDIKTG 531
Query: 339 RTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLL-PDERTISLCCWDSRTAE-RRNLLSL 394
+ L T G + Q T FN +++V+ D+ T+ L WD +T E RNL++L
Sbjct: 532 QCL--QTLQGPNKHQSAVTCLQFN--KNFVITSSDDGTVKL--WDLKTGEFIRNLVTL 583
Score = 63.5 bits (153), Expect = 3e-10
Identities = 63/260 (24%), Positives = 111/260 (42%), Gaps = 25/260 (9%)
Query: 166 IRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISF 225
+RTL H V + I+ SGS D TLK+ ++ + + +R +
Sbjct: 334 LRTLVGHTGGVWSSQMR--DNIIISGSTDRTLKV--WNAETGECIHTLYGHTSTVRCMHL 389
Query: 226 HPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGC 285
H ++ G++ TLR++DI T QC + H A+ V Y+ V+G+ D
Sbjct: 390 HEKR--VVSGSRDATLRVWDIETGQCL---HVLMGHVAAVRCVQYD--GRRVVSGAYDFM 442
Query: 286 IKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYT 345
+K+WD + C+ T + H V S F + +++S D+ ++W++ TG + T
Sbjct: 443 VKVWDPETETCLHTLQ-GHTN-RVYSLQF--DGIHVVSGSLDTSIRVWDVETGNCIHTLT 498
Query: 346 GAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVH 405
G H++ +D +L+ ++ WD +T + L G N +
Sbjct: 499 G--------HQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQ-GPNKHQSAVTC 549
Query: 406 SPTNPGF-MTCSDDFRARFW 424
N F +T SDD + W
Sbjct: 550 LQFNKNFVITSSDDGTVKLW 569
Score = 58.2 bits (139), Expect = 1e-08
Identities = 58/230 (25%), Positives = 95/230 (41%), Gaps = 53/230 (23%)
Query: 107 HKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVI 166
H R Y DG+ + +G+ D +K+ D E ET +
Sbjct: 420 HVAAVRCVQY--DGRRVVSGAYDFMVKVWDPE--------------TETC---------L 454
Query: 167 RTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFH 226
TL H + V L F + SGS D +++++D ++ + +++ H
Sbjct: 455 HTLQGHTNRVYSLQFDGIH--VVSGSLDTSIRVWD------------VETGNCIHTLTGH 500
Query: 227 PS-------GDFILV-GTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYV 278
S D ILV G T++++DI T QC + ++H A+ + +N N +
Sbjct: 501 QSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVI 558
Query: 279 TGSKDGCIKLWD---GVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSG 325
T S DG +KLWD G R + T E G V I + N+K + + G
Sbjct: 559 TSSDDGTVKLWDLKTGEFIRNLVTLESGGSGG-VVWRIRASNTKLVCAVG 607
Score = 50.8 bits (120), Expect = 2e-06
Identities = 37/150 (24%), Positives = 62/150 (41%), Gaps = 15/150 (10%)
Query: 275 NMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWE 334
N V+GS D +K+W V+ +C+ T H G S + I+S D K+W
Sbjct: 312 NRIVSGSDDNTLKVWSAVTGKCLRTL-VGHTGGVWSSQM---RDNIIISGSTDRTLKVWN 367
Query: 335 ISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSL 394
TG + G H + H + ++ R +L WD T + ++L +
Sbjct: 368 AETGECIHTLYG--------HTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVL-M 418
Query: 395 GHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
GH VRC+ + ++ + DF + W
Sbjct: 419 GHVAAVRCVQYDGRR--VVSGAYDFMVKVW 446
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 72.8 bits (177), Expect = 6e-13
Identities = 57/240 (23%), Positives = 102/240 (42%), Gaps = 28/240 (11%)
Query: 107 HKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVI 166
H GP + +S DG L A+ S D ++++ D R +
Sbjct: 62 HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARA-----------------------KCL 98
Query: 167 RTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFH 226
R L H V ++F P + LASG D + L+D R + + ++S F
Sbjct: 99 RVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLL--VGHRDSIQSSDFS 156
Query: 227 PSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCI 286
P+ + + G+ T+ ++D+ VS + H+ I + Y S++ + +GS D I
Sbjct: 157 PTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLCY-SASGLLASGSWDKTI 215
Query: 287 KLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTG 346
+W ++ + K H V S FS + ++ S+G + K+W+ +TG+ L G
Sbjct: 216 HIWKPTTSSLLIQL-KGH-VTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKG 273
Score = 47.8 bits (112), Expect = 2e-05
Identities = 42/177 (23%), Positives = 67/177 (37%), Gaps = 21/177 (11%)
Query: 260 QHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSK 319
QH + S ++ M +TGS+DGC+ W+ S + + + C FS +
Sbjct: 19 QHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCR--FSPDGH 76
Query: 320 YILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLC 379
S+ D +LW+++ + L L G Q E PD R ++
Sbjct: 77 LFASASCDCTVRLWDVARAKCL-----RVLKGHQ--------RSVETVSFSPDSRQLASG 123
Query: 380 CWDSRT------AERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTT 430
WD R + + L +GH + ++ SPT T S D W R T
Sbjct: 124 GWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVT 180
>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
Length = 797
Score = 72.8 bits (177), Expect = 6e-13
Identities = 69/284 (24%), Positives = 125/284 (44%), Gaps = 23/284 (8%)
Query: 168 TLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSK--PSAKRAFKYIQEAEMLR---- 221
TL H D V LAFHP E +L + S D+TLKL++ K P+ K A ++ R
Sbjct: 475 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIG 534
Query: 222 ---SISFHPSGDFILVGTQHPTLRLYDI--------NTFQCFVSCNPQDQHTDAICSVNY 270
S++ +G+ G T++ +++ +T++ V HTDA+ + Y
Sbjct: 535 PVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAY 594
Query: 271 NSSANMYVTGSKDGCIKLWDGVSN-RCITTF--EKAHDGAEVCSAIFSKNSKYILSSGKD 327
+ N ++ S DG ++LW+ CI T+ +K H G + ++++S
Sbjct: 595 SGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKH-GIPTSVDFIGCDPAHMVTSFNT 653
Query: 328 SVAKLWEISTGRTLVRYTGAGLSGRQV-HRTQAVFNHTEDYVLLPDERTISLCCWDSRTA 386
A ++++ T ++LV + SG Q + V +H V + + +D++T
Sbjct: 654 GSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTG 713
Query: 387 ERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTT 430
+ + + + H + V + P M+ S D R W S T
Sbjct: 714 KMIHSM-VAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKT 756
Score = 41.2 bits (95), Expect = 0.002
Identities = 58/243 (23%), Positives = 94/243 (38%), Gaps = 30/243 (12%)
Query: 106 SHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPV 165
+H GP S +G+ +G DA+I+ + M + S P + E + +
Sbjct: 531 AHIGPVLSLAISSNGEQCFSGGIDATIQWWN---MPSPSVDPYD---------TYEPNVL 578
Query: 166 IRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISF 225
TL H D V LA+ + L S S D T++L++ P K + I
Sbjct: 579 AGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWN---PQEKLPCICTYNGDKKHGIP- 634
Query: 226 HPSGDFILVGTQHPTLR-------LYDINTFQCFVSCNPQD----QHTDAICSVNYNSSA 274
S DFI H +YD+ T Q V + Q Q + I V + +
Sbjct: 635 -TSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTL 693
Query: 275 NMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWE 334
+ +T +D IK +D + + I + D V S N Y++S D +LW
Sbjct: 694 PVTITAHEDRHIKFFDNKTGKMIHSMVAHLDA--VTSLAVDPNGIYLMSGSHDCSIRLWN 751
Query: 335 IST 337
+ +
Sbjct: 752 LDS 754
Score = 40.4 bits (93), Expect = 0.003
Identities = 30/123 (24%), Positives = 55/123 (44%), Gaps = 7/123 (5%)
Query: 214 IQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSS 273
+Q + + HP+ + + ++ +D T + S H DA+ S+ + +
Sbjct: 678 LQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHS---MVAHLDAVTSLAVDPN 734
Query: 274 ANMYVTGSKDGCIKLWDGVSNRC---ITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVA 330
++GS D I+LW+ S C IT K D + F + YI S+G D++A
Sbjct: 735 GIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLD-ESIYDVAFHSSKAYIASAGADALA 793
Query: 331 KLW 333
K++
Sbjct: 794 KVF 796
Score = 38.1 bits (87), Expect = 0.016
Identities = 24/120 (20%), Positives = 55/120 (45%), Gaps = 6/120 (5%)
Query: 171 DHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGD 230
+H++ V HPT + + D +K FD + K + + + S++ P+G
Sbjct: 682 NHINRVVS---HPTLPVTITAHEDRHIKFFD--NKTGKMIHSMVAHLDAVTSLAVDPNGI 736
Query: 231 FILVGTQHPTLRLYDINTFQCFVSCNPQDQHTD-AICSVNYNSSANMYVTGSKDGCIKLW 289
+++ G+ ++RL+++++ C + D +I V ++SS + D K++
Sbjct: 737 YLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 796
Score = 33.9 bits (76), Expect = 0.29
Identities = 22/99 (22%), Positives = 48/99 (48%), Gaps = 5/99 (5%)
Query: 139 RMLAKSAMPIEVMMNETAQQNMENHP---VIRTLYDHVDEVTCLAFHPTEQILASGSRDY 195
R+++ +P+ + +E ++ +I ++ H+D VT LA P L SGS D
Sbjct: 686 RVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDC 745
Query: 196 TLKLFDYSKPSAKRAFKYIQEA--EMLRSISFHPSGDFI 232
+++L++ + + ++ E + ++FH S +I
Sbjct: 746 SIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYI 784
>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
Length = 713
Score = 72.8 bits (177), Expect = 6e-13
Identities = 69/284 (24%), Positives = 125/284 (44%), Gaps = 23/284 (8%)
Query: 168 TLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSK--PSAKRAFKYIQEAEMLR---- 221
TL H D V LAFHP E +L + S D+TLKL++ K P+ K A ++ R
Sbjct: 391 TLRSHFDGVRALAFHPVEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIG 450
Query: 222 ---SISFHPSGDFILVGTQHPTLRLYDI--------NTFQCFVSCNPQDQHTDAICSVNY 270
S++ +G+ G T++ +++ +T++ V HTDA+ + Y
Sbjct: 451 PVLSLAISSNGEQCFSGGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAY 510
Query: 271 NSSANMYVTGSKDGCIKLWDGVSN-RCITTF--EKAHDGAEVCSAIFSKNSKYILSSGKD 327
+ N ++ S DG ++LW+ CI T+ +K H G + ++++S
Sbjct: 511 SGIKNQLLSCSADGTVRLWNPQEKLPCICTYNGDKKH-GIPTSVDFIGCDPAHMVTSFNT 569
Query: 328 SVAKLWEISTGRTLVRYTGAGLSGRQV-HRTQAVFNHTEDYVLLPDERTISLCCWDSRTA 386
A ++++ T ++LV + SG Q + V +H V + + +D++T
Sbjct: 570 GSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTG 629
Query: 387 ERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTT 430
+ + + + H + V + P M+ S D R W S T
Sbjct: 630 KMIHSM-VAHLDAVTSLAVDPNGIYLMSGSHDCSIRLWNLDSKT 672
Score = 41.2 bits (95), Expect = 0.002
Identities = 58/243 (23%), Positives = 94/243 (38%), Gaps = 30/243 (12%)
Query: 106 SHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPV 165
+H GP S +G+ +G DA+I+ + M + S P + E + +
Sbjct: 447 AHIGPVLSLAISSNGEQCFSGGIDATIQWWN---MPSPSVDPYD---------TYEPNVL 494
Query: 166 IRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISF 225
TL H D V LA+ + L S S D T++L++ P K + I
Sbjct: 495 AGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWN---PQEKLPCICTYNGDKKHGIP- 550
Query: 226 HPSGDFILVGTQHPTLR-------LYDINTFQCFVSCNPQD----QHTDAICSVNYNSSA 274
S DFI H +YD+ T Q V + Q Q + I V + +
Sbjct: 551 -TSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSGLQSNNHINRVVSHPTL 609
Query: 275 NMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWE 334
+ +T +D IK +D + + I + D V S N Y++S D +LW
Sbjct: 610 PVTITAHEDRHIKFFDNKTGKMIHSMVAHLDA--VTSLAVDPNGIYLMSGSHDCSIRLWN 667
Query: 335 IST 337
+ +
Sbjct: 668 LDS 670
Score = 40.4 bits (93), Expect = 0.003
Identities = 30/123 (24%), Positives = 55/123 (44%), Gaps = 7/123 (5%)
Query: 214 IQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSS 273
+Q + + HP+ + + ++ +D T + S H DA+ S+ + +
Sbjct: 594 LQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHS---MVAHLDAVTSLAVDPN 650
Query: 274 ANMYVTGSKDGCIKLWDGVSNRC---ITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVA 330
++GS D I+LW+ S C IT K D + F + YI S+G D++A
Sbjct: 651 GIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLD-ESIYDVAFHSSKAYIASAGADALA 709
Query: 331 KLW 333
K++
Sbjct: 710 KVF 712
Score = 38.1 bits (87), Expect = 0.016
Identities = 24/120 (20%), Positives = 55/120 (45%), Gaps = 6/120 (5%)
Query: 171 DHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGD 230
+H++ V HPT + + D +K FD + K + + + S++ P+G
Sbjct: 598 NHINRVVS---HPTLPVTITAHEDRHIKFFD--NKTGKMIHSMVAHLDAVTSLAVDPNGI 652
Query: 231 FILVGTQHPTLRLYDINTFQCFVSCNPQDQHTD-AICSVNYNSSANMYVTGSKDGCIKLW 289
+++ G+ ++RL+++++ C + D +I V ++SS + D K++
Sbjct: 653 YLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVF 712
Score = 33.9 bits (76), Expect = 0.29
Identities = 22/99 (22%), Positives = 48/99 (48%), Gaps = 5/99 (5%)
Query: 139 RMLAKSAMPIEVMMNETAQQNMENHP---VIRTLYDHVDEVTCLAFHPTEQILASGSRDY 195
R+++ +P+ + +E ++ +I ++ H+D VT LA P L SGS D
Sbjct: 602 RVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIYLMSGSHDC 661
Query: 196 TLKLFDYSKPSAKRAFKYIQEA--EMLRSISFHPSGDFI 232
+++L++ + + ++ E + ++FH S +I
Sbjct: 662 SIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYI 700
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 72.4 bits (176), Expect = 7e-13
Identities = 52/226 (23%), Positives = 97/226 (42%), Gaps = 30/226 (13%)
Query: 104 VTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENH 163
+T H P + +LI GS SI++ D +E
Sbjct: 59 LTGHTSPVESVRLNTPEELIVAGSQSGSIRVWD-----------------------LEAA 95
Query: 164 PVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSI 223
++RTL H + L FHP + +ASGS+D +KL+D + F+Y ++ +R +
Sbjct: 96 KILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGC--VFRYRGHSQAVRCL 153
Query: 224 SFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKD 283
F P G ++ T++L+D+ + + HT + V ++ + + +GS D
Sbjct: 154 RFSPDGKWLASAADDHTVKLWDLTAGKMM---SEFPGHTGPVNVVEFHPNEYLLASGSSD 210
Query: 284 GCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSV 329
I+ WD + ++ E + V S +F+ + + S +DS+
Sbjct: 211 RTIRFWDLEKFQVVSCIE--GEPGPVRSVLFNPDGCCLYSGCQDSL 254
Score = 61.6 bits (148), Expect = 1e-09
Identities = 53/197 (26%), Positives = 80/197 (40%), Gaps = 12/197 (6%)
Query: 228 SGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIK 287
SG + G + L+ IN C +S HT + SV N+ + V GS+ G I+
Sbjct: 32 SGRLLATGGDDCRVNLWSINKPNCIMSLTG---HTSPVESVRLNTPEELIVAGSQSGSIR 88
Query: 288 LWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGA 347
+WD + + + T H A +CS F +++ S +D+ KLW+I + RY G
Sbjct: 89 VWDLEAAKILRTL-MGHK-ANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGH 146
Query: 348 GLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSP 407
Q R + D+ T+ L WD TA + GH V + P
Sbjct: 147 S----QAVRCLRFSPDGKWLASAADDHTVKL--WD-LTAGKMMSEFPGHTGPVNVVEFHP 199
Query: 408 TNPGFMTCSDDFRARFW 424
+ S D RFW
Sbjct: 200 NEYLLASGSSDRTIRFW 216
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 71.2 bits (173), Expect = 2e-12
Identities = 51/204 (25%), Positives = 93/204 (45%), Gaps = 20/204 (9%)
Query: 225 FHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHT-----DAICSVNYNSSANMYVT 279
F P G +++ G+ + +++ T + Q Q DA+ + ++ M T
Sbjct: 222 FSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDNFMMMDDAVLCMCFSRDTEMLAT 281
Query: 280 GSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGR 339
G++DG IK+W S +C+ FE+AH C + FSK+S ILS+ D ++ + +G+
Sbjct: 282 GAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLS-FSKDSSQILSASFDQTIRIHGLKSGK 340
Query: 340 TLVRYTGAGLSGRQVHRTQAVFNHTEDYVL-LPDERTISLCCWDSRTAERRNLL-----S 393
TL + G +A F Y++ + T+ + W+ +T E N +
Sbjct: 341 TLKEF-----RGHSSFVNEATFTQDGHYIISASSDGTVKI--WNMKTTECSNTFKSLGST 393
Query: 394 LGHNNIVRCIVHSPTNP-GFMTCS 416
G + V ++ P NP F+ C+
Sbjct: 394 AGTDITVNSVILLPKNPEHFVVCN 417
Score = 58.2 bits (139), Expect = 1e-08
Identities = 74/364 (20%), Positives = 141/364 (38%), Gaps = 48/364 (13%)
Query: 77 PGTGIDLEFDADVQTMSPEASEYETCYVTSH-----KGPCRVATYSRDGQLIATGSADAS 131
PG IDL F E ++ T ++ H K A +S DGQ + TGS D
Sbjct: 180 PGMTIDL-FRGKAAVKDVEEEKFPT-QLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGF 237
Query: 132 IKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDEVTCLAFHPTEQILASG 191
I++ + + I + AQ N + D D V C+ F ++LA+G
Sbjct: 238 IEVWNF------TTGKIRKDLKYQAQDNF-------MMMD--DAVLCMCFSRDTEMLATG 282
Query: 192 SRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVGTQHPTLRLYDINTFQC 251
++D +K++ R F+ ++ + +SF IL + T+R++ + + +
Sbjct: 283 AQDGKIKVWKIQSGQCLRRFER-AHSKGVTCLSFSKDSSQILSASFDQTIRIHGLKSGKT 341
Query: 252 FVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCS 311
H+ + + + ++ S DG +K+W+ + C TF+ A
Sbjct: 342 LKEFR---GHSSFVNEATFTQDGHYIISASSDGTVKIWNMKTTECSNTFKSLGSTAGTDI 398
Query: 312 AIFS-----KNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQV------HRTQAV 360
+ S KN ++ + + + + + G+ + ++ G R + +
Sbjct: 399 TVNSVILLPKNPEHFVVCNRSNTVVIMNMQ-GQIVRSFSSGKREGGDFVCCALSPRGEWI 457
Query: 361 FNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFR 420
+ ED+VL C+ + T + L++ H V I H P T S+D
Sbjct: 458 YCVGEDFVLY---------CFSTVTGKLERTLTV-HEKDVIGIAHHPHQNLIATYSEDGL 507
Query: 421 ARFW 424
+ W
Sbjct: 508 LKLW 511
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 70.1 bits (170), Expect = 4e-12
Identities = 62/261 (23%), Positives = 108/261 (41%), Gaps = 17/261 (6%)
Query: 165 VIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSIS 224
V+ T + H D ++ FHP+ LA+ S D T+KL+D K F+ + + S +
Sbjct: 386 VLLTGFGHTDWLSDCCFHPSGDKLATSSGDTTVKLWDLCKGDCILTFE--GHSRAVWSCT 443
Query: 225 FHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDG 284
+H G+F+ + T +++D+N+ +C + HTD++ S+ + +N +T S D
Sbjct: 444 WHSCGNFVASSSLDKTSKIWDVNSERCRCTLY---GHTDSVNSIEFFPFSNTLLTSSADK 500
Query: 285 CIKLWDGVSNRC-ITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVR 343
+ +WD + C + + H + AIF I S V KLW+ +V
Sbjct: 501 TLSIWDARTGICEQSLYGHMH---SINDAIFDPRGHMIASCDACGVTKLWDFRKLLPIVS 557
Query: 344 YTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSLGHNNIVRCI 403
G +V+ + VL + D ++ E L +GH N +
Sbjct: 558 IDIGPSPGNEVN------FDSSGRVLAQASGNGVIHLLDLKSGEIHKL--MGHENEAHTV 609
Query: 404 VHSPTNPGFMTCSDDFRARFW 424
V S + D R W
Sbjct: 610 VFSHDGEILFSGGSDGTVRTW 630
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 69.3 bits (168), Expect = 6e-12
Identities = 76/303 (25%), Positives = 120/303 (39%), Gaps = 53/303 (17%)
Query: 167 RTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFH 226
+ L H V+ F + L SGS D T+KL+D S R F++ +A ++ S
Sbjct: 96 KILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVEC-SIT 154
Query: 227 PSGDFILVGTQHPTLRLYDINTFQCF---------VSCN--------------------- 256
++ + T+R +D+ T + VSC
Sbjct: 155 GDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
Query: 257 ----------PQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDG 306
+D HT +I S ++ + + S D CIK+WD S + T KAH
Sbjct: 215 DAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSN 274
Query: 307 AEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNH-TE 365
A + + F+ + ++ +S D K+W + TG R GA ++ Q H H
Sbjct: 275 A-ISNCCFTFSGHFLCTSSWDKNLKIWNVHTGE--FRNCGACVTLMQGHEGSVSSCHFAR 331
Query: 366 DYVLLPD---ERTISLCCWDSRTAERRNLLSL-GHNNIVRCIVHSPTNPGFMTCSDDFRA 421
D L +RT+++ WD AE LSL GHN+ V + S ++ S D
Sbjct: 332 DSSFLISGGFDRTVAI--WD--VAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTM 387
Query: 422 RFW 424
R W
Sbjct: 388 RLW 390
Score = 60.8 bits (146), Expect = 2e-09
Identities = 57/255 (22%), Positives = 105/255 (41%), Gaps = 33/255 (12%)
Query: 116 YSRDGQLIATG-SADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVD 174
+S DG+ + +G D I I+D E N T +++H H
Sbjct: 194 FSPDGKYVVSGFDVDHGICIMDAE--------------NITTVSVIKDH--------HTR 231
Query: 175 EVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILV 234
+T F P Q +AS S D +K++D + + + + + F SG F+
Sbjct: 232 SITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAH-SNAISNCCFTFSGHFLCT 290
Query: 235 GTQHPTLRLYDINTFQ---CFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDG 291
+ L++++++T + C H ++ S ++ ++ ++G D + +WD
Sbjct: 291 SSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDV 350
Query: 292 VSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLW---EISTGRTLVRYTGA- 347
+ + +D V S N K+ILS+ KD +LW EI +++Y A
Sbjct: 351 AEGYRKLSLKGHNDW--VMDVAISNNKKWILSASKDRTMRLWNIEEIDEIPLVIKYKKAV 408
Query: 348 GLSGRQVHRTQAVFN 362
GL +Q R F+
Sbjct: 409 GLKLKQCERCDRPFS 423
>gi|38327642 WD repeat domain 55 [Homo sapiens]
Length = 383
Score = 67.4 bits (163), Expect = 2e-11
Identities = 71/283 (25%), Positives = 120/283 (42%), Gaps = 32/283 (11%)
Query: 84 EFDADVQTMSPEASEYETCYVTS---HKGPCRVATYSRDGQLIATGSADASIKILDTE-- 138
+ D DV S E ET + S H CR +S DGQ + T S D +I +LD E
Sbjct: 57 DVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVSKDKAIHVLDVEQG 116
Query: 139 ----RMLAKSAMPIE--VMMNETAQQNMENHPVIR-----------TLYDHVDEVTCLAF 181
R+ PI ++++E ++ IR + H + + +A
Sbjct: 117 QLERRVSKAHGAPINSLLLVDENVLATGDDTGGIRLWDQRKEGPLMDMRQHEEYIADMAL 176
Query: 182 HPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEM--LRSISFHPSGDFILVGTQHP 239
P +++L + S D L +F+ +R F+ + E + L S++ G + G+
Sbjct: 177 DPAKKLLLTASGDGCLGIFNIK----RRRFELLSEPQSGDLTSVTLMKWGKKVACGSSEG 232
Query: 240 TLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITT 299
T+ L++ N F S + C V S + TGS DG I+ + + NR + +
Sbjct: 233 TIYLFNWNGFGA-TSDRFALRAESIDCMVPVTES--LLCTGSTDGVIRAVNILPNRVVGS 289
Query: 300 FEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLV 342
+ H G V S +++ SSG D K W+++ R +V
Sbjct: 290 VGQ-HTGEPVEELALSHCGRFLASSGHDQRLKFWDMAQLRAVV 331
Score = 39.3 bits (90), Expect = 0.007
Identities = 29/114 (25%), Positives = 50/114 (43%), Gaps = 5/114 (4%)
Query: 179 LAFHPTEQILASGSRDYTLKLFDYS--KPSAKRAFKYIQEAEMLRSISFHPSGDFILVGT 236
LAFHP +LA+G D + +F YS + K + + R+++F G ++ +
Sbjct: 44 LAFHPARDLLAAGDVDGDVFVFSYSCQEGETKELWSSGHHLKACRAVAFSEDGQKLITVS 103
Query: 237 QHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWD 290
+ + + D+ Q + H I S+ N+ TG G I+LWD
Sbjct: 104 KDKAIHVLDVEQGQ--LERRVSKAHGAPINSL-LLVDENVLATGDDTGGIRLWD 154
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 67.0 bits (162), Expect = 3e-11
Identities = 61/277 (22%), Positives = 113/277 (40%), Gaps = 23/277 (8%)
Query: 168 TLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSK--PSAKRAFKYIQEAEMLRS--- 222
TL H D + LAFH ++ L + S D TLKL++ K + K A ++ R+
Sbjct: 440 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 499
Query: 223 ------------ISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNY 270
+ D + + P L + + + V + + H DA+ + +
Sbjct: 500 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 559
Query: 271 NSSANMYVTGSKDGCIKLWDGVSN--RCITTFEKAHD-GAEVCSAIFSKNSKYILSSGKD 327
+ ++ + S DG +++WD S+ C+ TF A + G A S +I++S +
Sbjct: 560 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 619
Query: 328 SVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAE 387
L+++ G L+ G SG + V +H + + + D+RT +
Sbjct: 620 GDTVLYDMEVGSALLTLESRGSSGPT--QINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 677
Query: 388 RRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
+ + + H + V C+ P M+ S D R W
Sbjct: 678 PVHSM-VAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 713
Score = 45.1 bits (105), Expect = 1e-04
Identities = 54/237 (22%), Positives = 93/237 (39%), Gaps = 24/237 (10%)
Query: 106 SHKGPCRVATYSRDGQLIATGSADASI---KILDTERMLAKSAMPIEVMMNETAQQNMEN 162
+H+GP + + +G ADA I KI D ++ +
Sbjct: 496 AHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD---------------LSMDPYDGYDP 540
Query: 163 HPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFD--YSKPSAKRAFKYIQEAEML 220
+ L H D V LAF PT Q LAS S D T++++D S P+ F E +
Sbjct: 541 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 600
Query: 221 RSISFHPSGD-FILVGTQHPTLRLYDINTFQCFVSCNPQ-DQHTDAICSVNYNSSANMYV 278
S++F + I+ + LYD+ ++ + I V + + + +
Sbjct: 601 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 660
Query: 279 TGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEI 335
T D I+ D + + + + AH A C A+ N +++S D +LW +
Sbjct: 661 TAHDDRGIRFLDNRTGKPVHSM-VAHLDAVTCLAV-DPNGAFLMSGSHDCSLRLWSL 715
Score = 37.4 bits (85), Expect = 0.027
Identities = 19/65 (29%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Query: 166 IRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQE--AEMLRSI 223
+ ++ H+D VTCLA P L SGS D +L+L+ + + ++ E + ++
Sbjct: 679 VHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAV 738
Query: 224 SFHPS 228
+ HPS
Sbjct: 739 ACHPS 743
Score = 33.5 bits (75), Expect = 0.38
Identities = 20/116 (17%), Positives = 51/116 (43%), Gaps = 3/116 (2%)
Query: 175 EVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILV 234
++ + HP + + + D ++ D + K + + + ++ P+G F++
Sbjct: 646 QINQVVSHPNQPLTITAHDDRGIRFLD--NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMS 703
Query: 235 GTQHPTLRLYDINTFQCFVSCNP-QDQHTDAICSVNYNSSANMYVTGSKDGCIKLW 289
G+ +LRL+ ++ C + +H +AI +V + S + + D K++
Sbjct: 704 GSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 759
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 67.0 bits (162), Expect = 3e-11
Identities = 61/277 (22%), Positives = 113/277 (40%), Gaps = 23/277 (8%)
Query: 168 TLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSK--PSAKRAFKYIQEAEMLRS--- 222
TL H D + LAFH ++ L + S D TLKL++ K + K A ++ R+
Sbjct: 433 TLRSHYDGIRSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRG 492
Query: 223 ------------ISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNY 270
+ D + + P L + + + V + + H DA+ + +
Sbjct: 493 PVLAVAMGSNSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAF 552
Query: 271 NSSANMYVTGSKDGCIKLWDGVSN--RCITTFEKAHD-GAEVCSAIFSKNSKYILSSGKD 327
+ ++ + S DG +++WD S+ C+ TF A + G A S +I++S +
Sbjct: 553 SPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRS 612
Query: 328 SVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAE 387
L+++ G L+ G SG + V +H + + + D+RT +
Sbjct: 613 GDTVLYDMEVGSALLTLESRGSSGPT--QINQVVSHPNQPLTITAHDDRGIRFLDNRTGK 670
Query: 388 RRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
+ + + H + V C+ P M+ S D R W
Sbjct: 671 PVHSM-VAHLDAVTCLAVDPNGAFLMSGSHDCSLRLW 706
Score = 45.1 bits (105), Expect = 1e-04
Identities = 54/237 (22%), Positives = 93/237 (39%), Gaps = 24/237 (10%)
Query: 106 SHKGPCRVATYSRDGQLIATGSADASI---KILDTERMLAKSAMPIEVMMNETAQQNMEN 162
+H+GP + + +G ADA I KI D ++ +
Sbjct: 489 AHRGPVLAVAMGSNSEYCYSGGADACIHSWKIPD---------------LSMDPYDGYDP 533
Query: 163 HPVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFD--YSKPSAKRAFKYIQEAEML 220
+ L H D V LAF PT Q LAS S D T++++D S P+ F E +
Sbjct: 534 SVLSHVLEGHGDAVWGLAFSPTSQRLASCSADGTVRIWDPSSSSPACLCTFPTASEHGVP 593
Query: 221 RSISFHPSGD-FILVGTQHPTLRLYDINTFQCFVSCNPQ-DQHTDAICSVNYNSSANMYV 278
S++F + I+ + LYD+ ++ + I V + + + +
Sbjct: 594 TSVAFTSTEPAHIVASFRSGDTVLYDMEVGSALLTLESRGSSGPTQINQVVSHPNQPLTI 653
Query: 279 TGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEI 335
T D I+ D + + + + AH A C A+ N +++S D +LW +
Sbjct: 654 TAHDDRGIRFLDNRTGKPVHSM-VAHLDAVTCLAV-DPNGAFLMSGSHDCSLRLWSL 708
Score = 37.4 bits (85), Expect = 0.027
Identities = 19/65 (29%), Positives = 34/65 (52%), Gaps = 2/65 (3%)
Query: 166 IRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQE--AEMLRSI 223
+ ++ H+D VTCLA P L SGS D +L+L+ + + ++ E + ++
Sbjct: 672 VHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAV 731
Query: 224 SFHPS 228
+ HPS
Sbjct: 732 ACHPS 736
Score = 33.5 bits (75), Expect = 0.38
Identities = 20/116 (17%), Positives = 51/116 (43%), Gaps = 3/116 (2%)
Query: 175 EVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILV 234
++ + HP + + + D ++ D + K + + + ++ P+G F++
Sbjct: 639 QINQVVSHPNQPLTITAHDDRGIRFLD--NRTGKPVHSMVAHLDAVTCLAVDPNGAFLMS 696
Query: 235 GTQHPTLRLYDINTFQCFVSCNP-QDQHTDAICSVNYNSSANMYVTGSKDGCIKLW 289
G+ +LRL+ ++ C + +H +AI +V + S + + D K++
Sbjct: 697 GSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKALIASAGADALAKVF 752
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 66.2 bits (160), Expect = 5e-11
Identities = 58/242 (23%), Positives = 100/242 (41%), Gaps = 41/242 (16%)
Query: 104 VTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENH 163
+ +H G + S D + TG AD S+K D E++ +E + Q +
Sbjct: 492 IDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD-----------FELVKDENSTQKRLSV 540
Query: 164 PVIRTLYDHVDE-VTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRS 222
RTL +DE V C+++ P +++LA D T+K+F Y+ + S
Sbjct: 541 KQTRTL--QLDEDVLCVSYSPNQKLLAVSLLDCTVKIF------------YVDTLKFFLS 586
Query: 223 ISFHP----------SGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNS 272
+ H G I G+ ++++ ++ C S H D++ + +
Sbjct: 587 LYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFA---HDDSVMYLQFVP 643
Query: 273 SANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKL 332
++++ T KD IK WD I T E H E+ S + Y++SS D +L
Sbjct: 644 KSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQ--EIWCLAVSPSGDYVVSSSHDKSLRL 701
Query: 333 WE 334
WE
Sbjct: 702 WE 703
Score = 50.8 bits (120), Expect = 2e-06
Identities = 40/157 (25%), Positives = 72/157 (45%), Gaps = 18/157 (11%)
Query: 227 PSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCI 286
P G + VG + ++R++ + + + V+ N H AI ++ Y+ +GSKD I
Sbjct: 75 PDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG---HKAAITTLKYDQLGGRLASGSKDTDI 131
Query: 287 KLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTGRTLVRYTG 346
+WD ++ + K H A + A+F + +++SGKD++ K W++ T G
Sbjct: 132 IVWDVINESGLYRL-KGHKDA-ITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVG 189
Query: 347 AGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDS 383
HRT+ VLL +E+ + DS
Sbjct: 190 --------HRTE-----VWGLVLLSEEKRLITGASDS 213
Score = 49.3 bits (116), Expect = 7e-06
Identities = 37/162 (22%), Positives = 65/162 (40%), Gaps = 7/162 (4%)
Query: 175 EVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILV 234
EVTCL P LA G D ++++F F + A + ++ + G +
Sbjct: 67 EVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAA--ITTLKYDQLGGRLAS 124
Query: 235 GTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSN 294
G++ + ++D+ H DAI + N+ VT KD +K WD +
Sbjct: 125 GSKDTDIIVWDVINESGLYRLKG---HKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQ 181
Query: 295 RCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEIS 336
C T EV + K +++ DS ++W+I+
Sbjct: 182 HCFKTM--VGHRTEVWGLVLLSEEKRLITGASDSELRVWDIA 221
Score = 41.6 bits (96), Expect = 0.001
Identities = 64/307 (20%), Positives = 113/307 (36%), Gaps = 60/307 (19%)
Query: 168 TLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHP 227
T+ H +V L+F + S + D ++K+++ S R E F P
Sbjct: 410 TIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMT----CEYALCSFFVP 464
Query: 228 SGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIK 287
+++GT+ L+LYD+ + + D H A+ S++ + +VTG D +K
Sbjct: 465 GDRQVVIGTKTGKLQLYDLASGNLLETI---DAHDGALWSMSLSPDQRGFVTGGADKSVK 521
Query: 288 LWD------------GVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEI 335
WD +S + T + D V +S N K + S D K++ +
Sbjct: 522 FWDFELVKDENSTQKRLSVKQTRTLQLDED---VLCVSYSPNQKLLAVSLLDCTVKIFYV 578
Query: 336 ST--------GRTL------VRYTGAGLSGRQVHRT------------QAVFNHTEDYVL 369
T G L + + GA ++ R +++F H + +
Sbjct: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
Query: 370 L---PDERTI-------SLCCWDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDF 419
L P + WD+ E L GH+ + C+ SP+ ++ S D
Sbjct: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLE-GHHQEIWCLAVSPSGDYVVSSSHDK 697
Query: 420 RARFWYR 426
R W R
Sbjct: 698 SLRLWER 704
Score = 33.9 bits (76), Expect = 0.29
Identities = 26/123 (21%), Positives = 51/123 (41%), Gaps = 5/123 (4%)
Query: 168 TLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHP 227
T H +T L + LASGS+D + ++D S K ++A + F
Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDA--ITQALFLR 159
Query: 228 SGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIK 287
+ ++ + ++ +D++T CF H + + S +TG+ D ++
Sbjct: 160 EKNLLVTSGKDTMVKWWDLDTQHCF---KTMVGHRTEVWGLVLLSEEKRLITGASDSELR 216
Query: 288 LWD 290
+WD
Sbjct: 217 VWD 219
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 65.9 bits (159), Expect = 7e-11
Identities = 77/338 (22%), Positives = 139/338 (41%), Gaps = 56/338 (16%)
Query: 104 VTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENH 163
V H A +S DGQ IA+ AD ++++ E T ++ +E
Sbjct: 611 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAE----------------TGEKLLE-- 652
Query: 164 PVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSI 223
+ H DEV C AF ++ +A+ S D +K+ ++ + + Y + +E +
Sbjct: 653 -----IKAHEDEVLCCAFSTDDRFIATCSVDKKVKI--WNSMTGELVHTYDEHSEQVNCC 705
Query: 224 SFHPSGDFILV--GTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGS 281
F S +L+ G+ L+L+D+N +C N HT+++ ++ + + S
Sbjct: 706 HFTNSSHHLLLATGSSDCFLKLWDLNQKEC---RNTMFGHTNSVNHCRFSPDDKLLASCS 762
Query: 282 KDGCIKLWDGVS---------NRCITTFEKAHDGAEV----CSAIFSKNSKYILSSGKDS 328
DG +KLWD S + E + EV CS +S + I+ + K+
Sbjct: 763 ADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCS--WSADGARIMVAAKNK 820
Query: 329 VAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAER 388
+ L++I T L G +G F+ ++ +S C + +
Sbjct: 821 IF-LFDIHTSGLL----GEIHTGHHSTIQYCDFSPQNHLAVV----ALSQYCVELWNTDS 871
Query: 389 RNLLS--LGHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
R+ ++ GH + V ++ SP F+T SDD R W
Sbjct: 872 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 909
Score = 52.8 bits (125), Expect = 6e-07
Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 39/235 (16%)
Query: 111 CRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLY 170
C T S L+ATGS+D +K+ D +N+ +N T++
Sbjct: 704 CCHFTNSSHHLLLATGSSDCFLKLWD---------------LNQKECRN--------TMF 740
Query: 171 DHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKP------SAKRAFKYIQEAE-----M 219
H + V F P +++LAS S D TLKL+D + + K+ F +++ + +
Sbjct: 741 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 800
Query: 220 LRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVT 279
++ S+ G I+V ++ + L+DI+T + T C +++ ++ V
Sbjct: 801 VKCCSWSADGARIMVAAKN-KIFLFDIHTSGLLGEIHTGHHSTIQYC--DFSPQNHLAVV 857
Query: 280 GSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWE 334
C++LW+ +R + H + V +FS + L+S D +LWE
Sbjct: 858 ALSQYCVELWN-TDSRSKVADCRGH-LSWVHGVMFSPDGSSFLTSSDDQTIRLWE 910
Score = 51.2 bits (121), Expect = 2e-06
Identities = 70/316 (22%), Positives = 122/316 (38%), Gaps = 58/316 (18%)
Query: 116 YSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDE 175
+S DG T S D +I++ +T+++ SA VM+ + + + V+ DH+
Sbjct: 890 FSPDGSSFLTSSDDQTIRLWETKKVCKNSA----VMLKQEVDVVFQENEVMVLAVDHIRR 945
Query: 176 VTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVG 235
+ + T QI Y+ EA++ P +I G
Sbjct: 946 LQLINGR-TGQI------------------------DYLTEAQV-SCCCLSPHLQYIAFG 979
Query: 236 TQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNR 295
++ + + ++ + F S + QH + + + + ++ S D I++W+ ++
Sbjct: 980 DENGAIEILELVNNRIFQS---RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK 1036
Query: 296 CITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTG---RTLVRYTGAGLSGR 352
CI F + H V KNS+ +LS D K+W I TG + V + G LS
Sbjct: 1037 CI--FLRGHQET-VKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCD 1092
Query: 353 QVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSL----GHNNIVRCIVHSPT 408
H + + D +T + +D LL L GHN VRC S
Sbjct: 1093 ISHDATKFSSTSAD-------KTAKIWSFDL-------LLPLHELRGHNGCVRCSAFSVD 1138
Query: 409 NPGFMTCSDDFRARFW 424
+ T D+ R W
Sbjct: 1139 STLLATGDDNGEIRIW 1154
Score = 49.7 bits (117), Expect = 5e-06
Identities = 40/171 (23%), Positives = 65/171 (38%), Gaps = 7/171 (4%)
Query: 261 HTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKY 320
HTDA+ ++ + D ++++ + + KAH+ +C A FS + ++
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCA-FSTDDRF 671
Query: 321 ILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCC 380
I + D K+W TG + Y H T N + +L L
Sbjct: 672 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT----NSSHHLLLATGSSDCFLKL 727
Query: 381 WDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD 431
WD E RN + GH N V SP + +CS D + W S +
Sbjct: 728 WDLNQKECRNTM-FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 777
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 65.9 bits (159), Expect = 7e-11
Identities = 77/338 (22%), Positives = 139/338 (41%), Gaps = 56/338 (16%)
Query: 104 VTSHKGPCRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENH 163
V H A +S DGQ IA+ AD ++++ E T ++ +E
Sbjct: 600 VRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAE----------------TGEKLLE-- 641
Query: 164 PVIRTLYDHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSI 223
+ H DEV C AF ++ +A+ S D +K+ ++ + + Y + +E +
Sbjct: 642 -----IKAHEDEVLCCAFSTDDRFIATCSVDKKVKI--WNSMTGELVHTYDEHSEQVNCC 694
Query: 224 SFHPSGDFILV--GTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGS 281
F S +L+ G+ L+L+D+N +C N HT+++ ++ + + S
Sbjct: 695 HFTNSSHHLLLATGSSDCFLKLWDLNQKEC---RNTMFGHTNSVNHCRFSPDDKLLASCS 751
Query: 282 KDGCIKLWDGVS---------NRCITTFEKAHDGAEV----CSAIFSKNSKYILSSGKDS 328
DG +KLWD S + E + EV CS +S + I+ + K+
Sbjct: 752 ADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCS--WSADGARIMVAAKNK 809
Query: 329 VAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAER 388
+ L++I T L G +G F+ ++ +S C + +
Sbjct: 810 IF-LFDIHTSGLL----GEIHTGHHSTIQYCDFSPQNHLAVV----ALSQYCVELWNTDS 860
Query: 389 RNLLS--LGHNNIVRCIVHSPTNPGFMTCSDDFRARFW 424
R+ ++ GH + V ++ SP F+T SDD R W
Sbjct: 861 RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLW 898
Score = 52.8 bits (125), Expect = 6e-07
Identities = 55/235 (23%), Positives = 102/235 (43%), Gaps = 39/235 (16%)
Query: 111 CRVATYSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLY 170
C T S L+ATGS+D +K+ D +N+ +N T++
Sbjct: 693 CCHFTNSSHHLLLATGSSDCFLKLWD---------------LNQKECRN--------TMF 729
Query: 171 DHVDEVTCLAFHPTEQILASGSRDYTLKLFDYSKP------SAKRAFKYIQEAE-----M 219
H + V F P +++LAS S D TLKL+D + + K+ F +++ + +
Sbjct: 730 GHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVI 789
Query: 220 LRSISFHPSGDFILVGTQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVT 279
++ S+ G I+V ++ + L+DI+T + T C +++ ++ V
Sbjct: 790 VKCCSWSADGARIMVAAKN-KIFLFDIHTSGLLGEIHTGHHSTIQYC--DFSPQNHLAVV 846
Query: 280 GSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWE 334
C++LW+ +R + H + V +FS + L+S D +LWE
Sbjct: 847 ALSQYCVELWN-TDSRSKVADCRGH-LSWVHGVMFSPDGSSFLTSSDDQTIRLWE 899
Score = 51.2 bits (121), Expect = 2e-06
Identities = 70/316 (22%), Positives = 122/316 (38%), Gaps = 58/316 (18%)
Query: 116 YSRDGQLIATGSADASIKILDTERMLAKSAMPIEVMMNETAQQNMENHPVIRTLYDHVDE 175
+S DG T S D +I++ +T+++ SA VM+ + + + V+ DH+
Sbjct: 879 FSPDGSSFLTSSDDQTIRLWETKKVCKNSA----VMLKQEVDVVFQENEVMVLAVDHIRR 934
Query: 176 VTCLAFHPTEQILASGSRDYTLKLFDYSKPSAKRAFKYIQEAEMLRSISFHPSGDFILVG 235
+ + T QI Y+ EA++ P +I G
Sbjct: 935 LQLINGR-TGQI------------------------DYLTEAQV-SCCCLSPHLQYIAFG 968
Query: 236 TQHPTLRLYDINTFQCFVSCNPQDQHTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNR 295
++ + + ++ + F S + QH + + + + ++ S D I++W+ ++
Sbjct: 969 DENGAIEILELVNNRIFQS---RFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDK 1025
Query: 296 CITTFEKAHDGAEVCSAIFSKNSKYILSSGKDSVAKLWEISTG---RTLVRYTGAGLSGR 352
CI F + H V KNS+ +LS D K+W I TG + V + G LS
Sbjct: 1026 CI--FLRGHQET-VKDFRLLKNSR-LLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCD 1081
Query: 353 QVHRTQAVFNHTEDYVLLPDERTISLCCWDSRTAERRNLLSL----GHNNIVRCIVHSPT 408
H + + D +T + +D LL L GHN VRC S
Sbjct: 1082 ISHDATKFSSTSAD-------KTAKIWSFDL-------LLPLHELRGHNGCVRCSAFSVD 1127
Query: 409 NPGFMTCSDDFRARFW 424
+ T D+ R W
Sbjct: 1128 STLLATGDDNGEIRIW 1143
Score = 49.7 bits (117), Expect = 5e-06
Identities = 40/171 (23%), Positives = 65/171 (38%), Gaps = 7/171 (4%)
Query: 261 HTDAICSVNYNSSANMYVTGSKDGCIKLWDGVSNRCITTFEKAHDGAEVCSAIFSKNSKY 320
HTDA+ ++ + D ++++ + + KAH+ +C A FS + ++
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEI-KAHEDEVLCCA-FSTDDRF 660
Query: 321 ILSSGKDSVAKLWEISTGRTLVRYTGAGLSGRQVHRTQAVFNHTEDYVLLPDERTISLCC 380
I + D K+W TG + Y H T N + +L L
Sbjct: 661 IATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT----NSSHHLLLATGSSDCFLKL 716
Query: 381 WDSRTAERRNLLSLGHNNIVRCIVHSPTNPGFMTCSDDFRARFWYRRSTTD 431
WD E RN + GH N V SP + +CS D + W S +
Sbjct: 717 WDLNQKECRNTM-FGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANE 766
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,961,372
Number of Sequences: 37866
Number of extensions: 673277
Number of successful extensions: 3654
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 147
Number of HSP's successfully gapped in prelim test: 136
Number of HSP's that attempted gapping in prelim test: 1610
Number of HSP's gapped (non-prelim): 1140
length of query: 431
length of database: 18,247,518
effective HSP length: 105
effective length of query: 326
effective length of database: 14,271,588
effective search space: 4652537688
effective search space used: 4652537688
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.