Search of human proteins with 7262393

Search of human proteins with 7262393

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|7262393 ATP-binding cassette, sub-family D (ALD), member 1
[Homo sapiens]
         (745 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|7262393 ATP-binding cassette, sub-family D (ALD), member 1 [H...  1473   0.0  
gi|9945308 ATP-binding cassette, sub-family D, member 2 [Homo sa...   948   0.0  
gi|4506341 ATP-binding cassette, sub-family D, member 3 isoform ...   457   e-128
gi|4826958 ATP-binding cassette, sub-family D, member 4 [Homo sa...   226   8e-59
gi|169881286 ATP-binding cassette, sub-family D, member 3 isofor...   121   3e-27
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C...    72   2e-12
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor...    69   1e-11
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor...    69   1e-11
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ...    67   8e-11
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ...    65   3e-10
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member...    65   3e-10
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ...    64   5e-10
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa...    63   9e-10
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho...    63   9e-10
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A...    63   1e-09
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B...    62   1e-09
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member...    62   2e-09
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s...    62   2e-09
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ...    62   3e-09
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ...    61   3e-09
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa...    61   3e-09
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is...    60   1e-08
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]            58   4e-08
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is...    57   5e-08
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member...    57   6e-08
gi|90421313 cystic fibrosis transmembrane conductance regulator ...    57   8e-08
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor...    55   2e-07
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ...    54   4e-07
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo...    52   2e-06
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor...    52   2e-06

>gi|7262393 ATP-binding cassette, sub-family D (ALD), member 1 [Homo
           sapiens]
          Length = 745

 Score = 1473 bits (3813), Expect = 0.0
 Identities = 745/745 (100%), Positives = 745/745 (100%)

Query: 1   MPVLSRPRPWRGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPAGEPTQEASGV 60
           MPVLSRPRPWRGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPAGEPTQEASGV
Sbjct: 1   MPVLSRPRPWRGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPARGLQAPAGEPTQEASGV 60

Query: 61  AAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLAR 120
           AAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLAR
Sbjct: 61  AAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLAR 120

Query: 121 CIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTY 180
           CIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTY
Sbjct: 121 CIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTY 180

Query: 181 YRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGT 240
           YRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGT
Sbjct: 181 YRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGT 240

Query: 241 AWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHE 300
           AWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHE
Sbjct: 241 AWPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHE 300

Query: 301 VELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSES 360
           VELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSES
Sbjct: 301 VELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSES 360

Query: 361 DAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVH 420
           DAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVH
Sbjct: 361 DAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVH 420

Query: 421 EMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENIP 480
           EMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENIP
Sbjct: 421 EMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENIP 480

Query: 481 IVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMF 540
           IVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMF
Sbjct: 481 IVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMF 540

Query: 541 YIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCD 600
           YIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCD
Sbjct: 541 YIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCD 600

Query: 601 WKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHR 660
           WKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHR
Sbjct: 601 WKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHR 660

Query: 661 PSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQIL 720
           PSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQIL
Sbjct: 661 PSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELCQIL 720

Query: 721 GEAVAPAHVPAPSPQGPGGLQGAST 745
           GEAVAPAHVPAPSPQGPGGLQGAST
Sbjct: 721 GEAVAPAHVPAPSPQGPGGLQGAST 745


>gi|9945308 ATP-binding cassette, sub-family D, member 2 [Homo
           sapiens]
          Length = 740

 Score =  948 bits (2450), Expect = 0.0
 Identities = 477/725 (65%), Positives = 588/725 (81%), Gaps = 27/725 (3%)

Query: 11  RGNTLKRTAVLLALAAYGAHKVYPLVRQCLAPA-RGLQAPAGEPTQEASGV--------A 61
           R +  KR A L+A AAY    +YP++ + L  +  G +  A  P  E + +         
Sbjct: 16  RSSAAKRAACLVA-AAYALKTLYPIIGKRLKQSGHGKKKAAAYPAAENTEILHCTETICE 74

Query: 62  AAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARC 121
               G+N  F ++LL L ++LFP+++  ETG L LHS AL+SRTFLS+YVA LDG++ + 
Sbjct: 75  KPSPGVNADFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDGKIVKS 134

Query: 122 IVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYY 181
           IV K PR F  +L++WL+IA+PATFVNSAIRYLE +LAL+FR+RLV HAY  YF+ QTYY
Sbjct: 135 IVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLECKLALAFRTRLVDHAYETYFTNQTYY 194

Query: 182 RVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTA 241
           +V NMDGRL NPDQSLTED++ F+ SVAHLYSNLTKP+LDV +TSYTL++ A SRGA   
Sbjct: 195 KVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQTATSRGASPI 254

Query: 242 WPSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEV 301
            P+ +AGLVV+ TA VL+A SPKFG+LVAEEA RKG LRY+HSR++AN EEIAFY GH+V
Sbjct: 255 GPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEEIAFYRGHKV 314

Query: 302 ELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESD 361
           E+  LQ+SY+ LA Q+NLIL +RLWY+M+EQFLMKYVWS+SGL+MVA+PIITATG+++ +
Sbjct: 315 EMKQLQKSYKALADQMNLILSKRLWYIMIEQFLMKYVWSSSGLIMVAIPIITATGFADGE 374

Query: 362 AEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHE 421
                    + +++ +VSERTEAFT ARNLL + ADAIERIMSSYKEVTELAGYTARV+ 
Sbjct: 375 ---------DGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVYN 425

Query: 422 MFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLK----IRGQVVDVEQGIICE 477
           MF VF++V+R  +KR   ++++++ S    ++G +VE PL     I+G+V+DV+ GIICE
Sbjct: 426 MFWVFDEVKRGIYKRTAVIQESESHS----KNGAKVELPLSDTLAIKGKVIDVDHGIICE 481

Query: 478 NIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQ 537
           N+PI+TP+GEVV + LN +VEEGMHLLITGPNGCGKSSLFRIL GLWP Y GVLYKPPPQ
Sbjct: 482 NVPIITPAGEVVASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEGVLYKPPPQ 541

Query: 538 RMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEA 597
            MFYIPQRPYMS+GSLRDQVIYPDSV+DM  KGY++QDLE IL  VHL+HI+QREGGW+A
Sbjct: 542 HMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWDA 601

Query: 598 MCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSI 657
           + DWKDVLSGGEKQR+GMARMFYH+PKYALLDECTSAVSIDVEGKIFQAAK AGI+LLSI
Sbjct: 602 VMDWKDVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISLLSI 661

Query: 658 THRPSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRLQELC 717
           THRPSLWKYHTHLLQFDGEGGW+FE+LD+A RL+L+EEKQ+LE QLAGIPKMQ+RL ELC
Sbjct: 662 THRPSLWKYHTHLLQFDGEGGWRFEQLDTAIRLTLSEEKQKLESQLAGIPKMQQRLNELC 721

Query: 718 QILGE 722
           +ILGE
Sbjct: 722 KILGE 726


>gi|4506341 ATP-binding cassette, sub-family D, member 3 isoform a
           [Homo sapiens]
          Length = 659

 Score =  457 bits (1176), Expect = e-128
 Identities = 245/621 (39%), Positives = 377/621 (60%), Gaps = 26/621 (4%)

Query: 64  KAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIV 123
           +A +++VF  RL+ +L+++ PR  C+ETG L L +  LVSRT+  V++ +    +   I+
Sbjct: 56  RAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGII 115

Query: 124 RKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRV 183
            +  + F   LL ++      + VN+ ++Y   +L L FR RL  + Y  Y    TYY++
Sbjct: 116 GRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKM 175

Query: 184 SNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWP 243
            N+D R+ NPDQ LT+DV  F  SV  LYSNL+KP LD+ +  + L  A  ++G      
Sbjct: 176 GNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPA---- 231

Query: 244 SAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVEL 303
           S +A LVV  +   L       G++   E + +GE RY++SR++ NSEEIAFY G++ E 
Sbjct: 232 SMMAYLVV--SGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREK 289

Query: 304 ALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAE 363
             +   ++ L   ++  +L R     ++  + KY+ +  G L+V+ P +       S   
Sbjct: 290 QTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDL-----SHPR 344

Query: 364 AVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMF 423
            +K    E  E+   S R         +L   + A+ RI+ + +E+T LAG+TAR+ E+ 
Sbjct: 345 HLKSTHSELLEDYYQSGR---------MLLRMSQALGRIVLAGREMTRLAGFTARITELM 395

Query: 424 QVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENIPIVT 483
           QV +D+    ++R    +  +      G  GV+V   +   G+++  +  I  +++P+ T
Sbjct: 396 QVLKDLNHGKYERTMVSQQEK------GIEGVQVIPLIPGAGEIIIADNIIKFDHVPLAT 449

Query: 484 PSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIP 543
           P+G+V++  LN  V  G ++LI GPNGCGKSSLFR+LG LWP +GG L KP   ++FY+P
Sbjct: 450 PNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVP 509

Query: 544 QRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKD 603
           QRPYM++G+LRDQVIYPD  ED +RKG S+  L+  LD V L HIL+REGGW+++ DW D
Sbjct: 510 QRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMD 569

Query: 604 VLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSL 663
           VLSGGEKQR+ MAR+FYH+P++A+LDECTSAVS+DVEG I+   +  GI L +++HR SL
Sbjct: 570 VLSGGEKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSL 629

Query: 664 WKYHTHLLQFDGEGGWKFEKL 684
           WK+H + L  DG G ++F+++
Sbjct: 630 WKHHEYYLHMDGRGNYEFKQI 650


>gi|4826958 ATP-binding cassette, sub-family D, member 4 [Homo
           sapiens]
          Length = 606

 Score =  226 bits (575), Expect = 8e-59
 Identities = 178/638 (27%), Positives = 302/638 (47%), Gaps = 58/638 (9%)

Query: 61  AAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLAR 120
           A A+  ++  FLQR L +L++LFP    +   +        +   F+   V  +  +   
Sbjct: 10  AGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGLIPSQYYG 69

Query: 121 CIVRKDPRAFGW-QLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQT 179
            +  KD   F     L  +LI L +T + S  ++    L +S+R  L  H +RLYF  + 
Sbjct: 70  VLGNKDLEGFKTLTFLAVMLIVLNST-LKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRA 128

Query: 180 YYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAG 239
           YY ++ +   + NPDQ +++DV  F   ++ + S L        ++ +TL+         
Sbjct: 129 YYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLI-------ISPFTLVYYTYQCFQS 181

Query: 240 TAW--PSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYG 297
           T W  P +I G  +  T        P   +LV +E + +G+ R+ H ++  N+E  AFY 
Sbjct: 182 TGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQE-KLEGDFRFKHMQIRVNAEPAAFYR 240

Query: 298 GHEVELALLQRSYQDLASQINLILLERLW-YVMLEQFLMKYVWSASGLLMVAVPIITATG 356
              VE     R  Q L      ++ + LW Y+ +  F   Y+ S    +++A+PI +   
Sbjct: 241 AGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTF--DYLGSILSYVVIAIPIFSGVY 298

Query: 357 YSESDAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYT 416
              S AE    + L  K   +       FT   +L T  +D              +AGYT
Sbjct: 299 GDLSPAEL---STLVSKNAFVCIYLISCFTQLIDLSTTLSD--------------VAGYT 341

Query: 417 ARVHEMFQVFEDV----QRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQ 472
            R+ ++ +   D+    Q C       L +++ G  T    G     P          + 
Sbjct: 342 HRIGQLRETLLDMSLKSQDCEI-----LGESEWGLDT--PPGWPAAEP---------ADT 385

Query: 473 GIICENIPIVTPSGEV-VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGG-- 529
             + E + I  PS +  ++  L++++ EG  LLITG  G GK+SL R+LGGLW +  G  
Sbjct: 386 AFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV 445

Query: 530 -VLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHI 588
            +L    P  + ++PQ+P+ + G+LR+QVIYP            ++ +   L++  L ++
Sbjct: 446 QMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNL 505

Query: 589 LQREGGWEAMCDWK--DVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQA 646
           + R  G +   DW   DVLS GE QR+  AR+FY +PKYA+LDE TSA++ +VE ++++ 
Sbjct: 506 VARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRI 565

Query: 647 AKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKL 684
            +  G+  +S+ HR SL K+H+ +L+  G G W+  ++
Sbjct: 566 GQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWELMRI 603


>gi|169881286 ATP-binding cassette, sub-family D, member 3 isoform b
           [Homo sapiens]
          Length = 236

 Score =  121 bits (303), Expect = 3e-27
 Identities = 64/176 (36%), Positives = 102/176 (57%)

Query: 64  KAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLARCIV 123
           +A +++VF  RL+ +L+++ PR  C+ETG L L +  LVSRT+  V++ +    +   I+
Sbjct: 56  RAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGII 115

Query: 124 RKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTYYRV 183
            +  + F   LL ++      + VN+ ++Y   +L L FR RL  + Y  Y    TYY++
Sbjct: 116 GRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKM 175

Query: 184 SNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAG 239
            N+D R+ NPDQ LT+DV  F  SV  LYSNL+KP LD+ +  + L  A  ++  G
Sbjct: 176 GNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQVLG 231


>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
            [Homo sapiens]
          Length = 1232

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 83/351 (23%), Positives = 147/351 (41%), Gaps = 40/351 (11%)

Query: 337  YVWSASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSE-RTEAFTIARNLLTAA 395
            Y W  + LL+  VPII  +G  E    A   A  +KKE E   +  TEA    R +++  
Sbjct: 852  YGWQLTLLLLAVVPIIAVSGIVEMKLLA-GNAKRDKKELEAAGKIATEAIENIRTVVSLT 910

Query: 396  ADA------IERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPR--ELEDAQAGS 447
             +       +E++   Y+  + +      +        D  +          L + Q   
Sbjct: 911  QERKFESMYVEKLYGPYRVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLI 970

Query: 448  GTIGRSGVRVEGPLKIRGQVVDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITG 507
             +    G++   P K  G +   E   +  N P  T +   V+  L++ V++G  L + G
Sbjct: 971  DSYSEEGLK---PDKFEGNITFNE---VVFNYP--TRANVPVLQGLSLEVKKGQTLALVG 1022

Query: 508  PNGCGKSSLFRILGGLWPTYGGVLYKPPPQ-----------RMFYIPQRPYMSVGSLRDQ 556
             +GCGKS++ ++L   +    G +     +           ++  + Q P +   S+ + 
Sbjct: 1023 SSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAEN 1082

Query: 557  VIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQR-EGGWEAMCDWKDV-LSGGEKQRIG 614
            + Y D+      +  S+ ++ +     ++H  ++     +E     K   LSGG+KQRI 
Sbjct: 1083 IAYGDN-----SRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIA 1137

Query: 615  MARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AGIALLSITHRPS 662
            +AR    +P+  LLDE TSA+  + E K+ Q A D    G   + I HR S
Sbjct: 1138 IARALIRQPQILLLDEATSALDTESE-KVVQEALDKAREGRTCIVIAHRLS 1187



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 52/191 (27%), Positives = 89/191 (46%), Gaps = 26/191 (13%)

Query: 489 VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPPQRMF------- 540
           ++  LN++V+ G  + + G +GCGKS+  +++  L+ P  G +       R F       
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470

Query: 541 ---YIPQRPYMSVGSLRDQVIYPD---SVEDMQRKGYSEQDLEAILDVVHLHHILQREGG 594
               + Q P +   ++ + + Y     +++++++        E I+ +      L  E G
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530

Query: 595 WEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AG 651
            +        LSGG+KQRI +AR     PK  LLDE TSA+  + E ++ QAA D    G
Sbjct: 531 AQ--------LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREG 581

Query: 652 IALLSITHRPS 662
              + I HR S
Sbjct: 582 RTTIVIAHRLS 592


>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
           [Homo sapiens]
          Length = 859

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 56/184 (30%), Positives = 87/184 (47%), Gaps = 21/184 (11%)

Query: 493 LNIRVEEGMHLLITGPNGCGKSSLFR-ILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVG 551
           L+  V  G  L + GP G GKSSL   +LG L P++G V       R+ Y+ Q+P++  G
Sbjct: 431 LSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG---RIAYVSQQPWVFSG 487

Query: 552 SLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQ--REGGWEAMCDWKDVLSGGE 609
           +LR  +++         K Y ++  E ++    L   LQ   +G    + D    LSGG+
Sbjct: 488 TLRSNILFG--------KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQ 539

Query: 610 KQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTH 669
           K R+ +AR  Y      LLD+  SAV  +V   +F+      + +  I H   +    TH
Sbjct: 540 KARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE------LCICQILHE-KITILVTH 592

Query: 670 LLQF 673
            LQ+
Sbjct: 593 QLQY 596


>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
           [Homo sapiens]
          Length = 1325

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 56/184 (30%), Positives = 87/184 (47%), Gaps = 21/184 (11%)

Query: 493 LNIRVEEGMHLLITGPNGCGKSSLFR-ILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVG 551
           L+  V  G  L + GP G GKSSL   +LG L P++G V       R+ Y+ Q+P++  G
Sbjct: 431 LSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHG---RIAYVSQQPWVFSG 487

Query: 552 SLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQ--REGGWEAMCDWKDVLSGGE 609
           +LR  +++         K Y ++  E ++    L   LQ   +G    + D    LSGG+
Sbjct: 488 TLRSNILFG--------KKYEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQ 539

Query: 610 KQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTH 669
           K R+ +AR  Y      LLD+  SAV  +V   +F+      + +  I H   +    TH
Sbjct: 540 KARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFE------LCICQILHE-KITILVTH 592

Query: 670 LLQF 673
            LQ+
Sbjct: 593 QLQY 596



 Score = 39.7 bits (91), Expect = 0.010
 Identities = 46/202 (22%), Positives = 87/202 (43%), Gaps = 23/202 (11%)

Query: 474  IICENIPIV-TPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVL- 531
            II +N+  + +P G +V+  L   ++    + I G  G GKSSL   L  L    G +  
Sbjct: 1041 IIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEPEGKIWI 1100

Query: 532  ---------YKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDV 582
                          ++M  IPQ P +  G++R  +   D   +     +++++L   L  
Sbjct: 1101 DKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNE-----HTDEELWNALQE 1152

Query: 583  VHLHHILQREGGW--EAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVE 640
            V L   ++   G     + +     S G++Q + +AR    + +  ++DE T+ V    +
Sbjct: 1153 VQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTD 1212

Query: 641  GKIFQAAKD--AGIALLSITHR 660
              I +  ++  A   +L+I HR
Sbjct: 1213 ELIQKKIREKFAHCTVLTIAHR 1234


>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
           sapiens]
          Length = 812

 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 53/190 (27%), Positives = 90/190 (47%), Gaps = 22/190 (11%)

Query: 489 VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPPQR--------- 538
           ++  L++ +E G  +   G +GCGKS+  ++L  L+ P  G VL+     +         
Sbjct: 587 ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646

Query: 539 -MFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQR-EGGWE 596
            +  +PQ P +   S+ + + Y D+   +        +++   +  ++H  ++     + 
Sbjct: 647 QIAIVPQEPVLFNCSIAENIAYGDNSRVVPL-----DEIKEAANAANIHSFIEGLPEKYN 701

Query: 597 AMCDWKDV-LSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AGI 652
                K   LSGG+KQR+ +AR    +PK  LLDE TSA+  D E K+ Q A D    G 
Sbjct: 702 TQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSE-KVVQHALDKARTGR 760

Query: 653 ALLSITHRPS 662
             L +THR S
Sbjct: 761 TCLVVTHRLS 770



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 35/126 (27%), Positives = 60/126 (47%), Gaps = 13/126 (10%)

Query: 542 IPQRPYMSVGSLRDQVIYP-DSV--EDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAM 598
           + Q P +   ++ + + Y  D V  E+M+R        + I++  +  + L  E G +  
Sbjct: 22  VSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQ-- 79

Query: 599 CDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDA--GIALLS 656
                 +SGG+KQRI +AR     PK  +LDE TSA+  + +  +  A + A  G   + 
Sbjct: 80  ------MSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIV 133

Query: 657 ITHRPS 662
           + HR S
Sbjct: 134 VAHRLS 139


>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 153/654 (23%), Positives = 239/654 (36%), Gaps = 123/654 (18%)

Query: 43  ARGLQAPAGEPTQEASGVAAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALV 102
           A G       P ++ASG    K             LL    P V         L  AAL 
Sbjct: 155 AEGFPGSGRPPPEQASGATLQK-------------LLSYTKPDVAFLVAASFFLIVAAL- 200

Query: 103 SRTFLSVYVAR-LDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALS 161
             TFL  Y  R +DG     +++K    F   ++   L+A+ ++F       +   +   
Sbjct: 201 GETFLPYYTGRAIDG----IVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFAR 256

Query: 162 FRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLD 221
              RL    +R   SQ+T +   N  G L +   S T  V    +   +++   T  +  
Sbjct: 257 LNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTG 316

Query: 222 VAVTSYTLLRAARSRGAGTAWPSAIAGL----VVFLTANVLRAFSPKFGELVAEEARRKG 277
           V V  ++L           +W  ++       ++ + +N+   +  +  + V     R  
Sbjct: 317 VVVFMFSL-----------SWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARAS 365

Query: 278 E-----LRYMHS-RVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERLWYVMLE 331
                 +  M + R  AN EE A     EV L  LQ+ Y+       L   E   Y    
Sbjct: 366 NTAEETISAMKTVRSFANEEEEA-----EVYLRKLQQVYK-------LNRKEAAAY---- 409

Query: 332 QFLMKYVW-SASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIARN 390
              M YVW S   LL+V V I+   G+     +             + S    AF I   
Sbjct: 410 ---MYYVWGSGLTLLVVQVSILYYGGHLVISGQ-------------MTSGNLIAFIIYEF 453

Query: 391 LLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTI 450
           +L    D +E + S Y  + +  G   +V E             ++P  + D        
Sbjct: 454 VL---GDCMESVGSVYSGLMQGVGAAEKVFEFID----------RQPTMVHDGSLA---- 496

Query: 451 GRSGVRVEGPLKIRGQVVDVEQGIICENIPIV--TPSGEVVVASLNIRVEEGMHLLITGP 508
                    P  + G+V         EN+     T     V+ +++  +  G    + GP
Sbjct: 497 ---------PDHLEGRVD-------FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540

Query: 509 NGCGKSSLFRILGGLWPTYGG-VLYKPPPQRMFYIPQRPYMS-VGSLRDQ--VIYPDSVE 564
           +G GKSS   IL   +P  GG VL    P   +      Y+  V SL  Q  V++  S+ 
Sbjct: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAY---DHKYLHRVISLVSQEPVLFARSIT 597

Query: 565 DMQRKGYSEQDLEAILDVVHLHH----ILQREGGWEAMCDWKDV-LSGGEKQRIGMARMF 619
           D    G      E +++     +    I++ + G+      K   LSGG+KQR+ MAR  
Sbjct: 598 DNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARAL 657

Query: 620 YHRPKYALLDECTSAVSIDVEGKIFQAAKD--AGIALLSITHRPSLWKYHTHLL 671
              P   +LDE TSA+  + E  I QA         +L I HR S  + H HL+
Sbjct: 658 VRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVE-HAHLI 710


>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 153/654 (23%), Positives = 239/654 (36%), Gaps = 123/654 (18%)

Query: 43  ARGLQAPAGEPTQEASGVAAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALV 102
           A G       P ++ASG    K             LL    P V         L  AAL 
Sbjct: 155 AEGFPGSGRPPPEQASGATLQK-------------LLSYTKPDVAFLVAASFFLIVAAL- 200

Query: 103 SRTFLSVYVAR-LDGRLARCIVRKDPRAFGWQLLQWLLIALPATFVNSAIRYLEGQLALS 161
             TFL  Y  R +DG     +++K    F   ++   L+A+ ++F       +   +   
Sbjct: 201 GETFLPYYTGRAIDG----IVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFAR 256

Query: 162 FRSRLVAHAYRLYFSQQTYYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLD 221
              RL    +R   SQ+T +   N  G L +   S T  V    +   +++   T  +  
Sbjct: 257 LNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTG 316

Query: 222 VAVTSYTLLRAARSRGAGTAWPSAIAGL----VVFLTANVLRAFSPKFGELVAEEARRKG 277
           V V  ++L           +W  ++       ++ + +N+   +  +  + V     R  
Sbjct: 317 VVVFMFSL-----------SWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARAS 365

Query: 278 E-----LRYMHS-RVVANSEEIAFYGGHEVELALLQRSYQDLASQINLILLERLWYVMLE 331
                 +  M + R  AN EE A     EV L  LQ+ Y+       L   E   Y    
Sbjct: 366 NTAEETISAMKTVRSFANEEEEA-----EVYLRKLQQVYK-------LNRKEAAAY---- 409

Query: 332 QFLMKYVW-SASGLLMVAVPIITATGYSESDAEAVKKAALEKKEEELVSERTEAFTIARN 390
              M YVW S   LL+V V I+   G+     +             + S    AF I   
Sbjct: 410 ---MYYVWGSGLTLLVVQVSILYYGGHLVISGQ-------------MTSGNLIAFIIYEF 453

Query: 391 LLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTI 450
           +L    D +E + S Y  + +  G   +V E             ++P  + D        
Sbjct: 454 VL---GDCMESVGSVYSGLMQGVGAAEKVFEFID----------RQPTMVHDGSLA---- 496

Query: 451 GRSGVRVEGPLKIRGQVVDVEQGIICENIPIV--TPSGEVVVASLNIRVEEGMHLLITGP 508
                    P  + G+V         EN+     T     V+ +++  +  G    + GP
Sbjct: 497 ---------PDHLEGRVD-------FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540

Query: 509 NGCGKSSLFRILGGLWPTYGG-VLYKPPPQRMFYIPQRPYMS-VGSLRDQ--VIYPDSVE 564
           +G GKSS   IL   +P  GG VL    P   +      Y+  V SL  Q  V++  S+ 
Sbjct: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAY---DHKYLHRVISLVSQEPVLFARSIT 597

Query: 565 DMQRKGYSEQDLEAILDVVHLHH----ILQREGGWEAMCDWKDV-LSGGEKQRIGMARMF 619
           D    G      E +++     +    I++ + G+      K   LSGG+KQR+ MAR  
Sbjct: 598 DNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARAL 657

Query: 620 YHRPKYALLDECTSAVSIDVEGKIFQAAKD--AGIALLSITHRPSLWKYHTHLL 671
              P   +LDE TSA+  + E  I QA         +L I HR S  + H HL+
Sbjct: 658 VRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVE-HAHLI 710


>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 2 [Homo sapiens]
          Length = 723

 Score = 63.9 bits (154), Expect = 5e-10
 Identities = 97/392 (24%), Positives = 154/392 (39%), Gaps = 54/392 (13%)

Query: 312 DLASQ-INLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSESDAEAVKKAAL 370
           DL SQ IN+ L   +    +  F+    W  S +  +  PII     S    +  K+ + 
Sbjct: 298 DLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMV--SNIYGKYYKRLSK 355

Query: 371 EKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARVHEMFQVFEDVQ 430
           E                 +N L  A++  E  +S+ K V   A          +  + V 
Sbjct: 356 E----------------VQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVY 399

Query: 431 RCHFKRPRELEDAQAGSGTIGR--SGV-RVEGPLKIRGQVVD---------------VEQ 472
           + + K          GSG++G   SG+ +  G  +   + +D               +E 
Sbjct: 400 KLNRKEAAAYMYYVWGSGSVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEG 459

Query: 473 GIICENIPIV--TPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGG- 529
            +  EN+     T     V+ +++  +  G    + GP+G GKSS   IL   +P  GG 
Sbjct: 460 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 519

Query: 530 VLYKPPPQRMFYIPQRPYMS-VGSLRDQ--VIYPDSVEDMQRKGYSEQDLEAILDVVHLH 586
           VL    P   +      Y+  V SL  Q  V++  S+ D    G      E +++     
Sbjct: 520 VLLDGKPISAY---DHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKA 576

Query: 587 H----ILQREGGWEAMCDWKDV-LSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEG 641
           +    I++ + G+      K   LSGG+KQR+ MAR     P   +LDE TSA+  + E 
Sbjct: 577 NAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEY 636

Query: 642 KIFQAAKD--AGIALLSITHRPSLWKYHTHLL 671
            I QA         +L I HR S  + H HL+
Sbjct: 637 LIQQAIHGNLQKHTVLIIAHRLSTVE-HAHLI 667


>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
           sapiens]
          Length = 1280

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 54/203 (26%), Positives = 92/203 (45%), Gaps = 26/203 (12%)

Query: 489 VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPPQRMF------- 540
           ++  LN++V+ G  + + G +GCGKS+  +++  L+ PT G V       R         
Sbjct: 409 ILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLRE 468

Query: 541 ---YIPQRPYMSVGSLRDQVIYPD---SVEDMQRKGYSEQDLEAILDVVHLHHILQREGG 594
               + Q P +   ++ + + Y     +++++++        + I+ + H    L  E G
Sbjct: 469 IIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERG 528

Query: 595 WEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AG 651
            +        LSGG+KQRI +AR     PK  LLDE TSA+  + E  + Q A D    G
Sbjct: 529 AQ--------LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA-VVQVALDKARKG 579

Query: 652 IALLSITHRPSLWKYHTHLLQFD 674
              + I HR S  +    +  FD
Sbjct: 580 RTTIVIAHRLSTVRNADVIAGFD 602



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 52/190 (27%), Positives = 89/190 (46%), Gaps = 22/190 (11%)

Query: 489  VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPPQRMF------- 540
            V+  L++ V++G  L + G +GCGKS++ ++L   + P  G VL      +         
Sbjct: 1052 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRA 1111

Query: 541  ---YIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEA 597
                + Q P +   S+ + + Y D+      +  S++++       ++H  ++      +
Sbjct: 1112 HLGIVSQEPILFDCSIAENIAYGDN-----SRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166

Query: 598  --MCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AGI 652
              + D    LSGG+KQRI +AR    +P   LLDE TSA+  + E K+ Q A D    G 
Sbjct: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESE-KVVQEALDKAREGR 1225

Query: 653  ALLSITHRPS 662
              + I HR S
Sbjct: 1226 TCIVIAHRLS 1235


>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
           sapiens]
          Length = 808

 Score = 63.2 bits (152), Expect = 9e-10
 Identities = 91/409 (22%), Positives = 164/409 (40%), Gaps = 88/409 (21%)

Query: 326 WYVMLEQFLMKYVWSASGLL---MVAVPIITATGYSESDAEAVKKAALEKK---EEELVS 379
           WY +LE  + + +  +S +    + A+P + +    E +A+  ++   E K   ++E V+
Sbjct: 408 WYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVA 467

Query: 380 ERTEAFT--------------IARNLLTAAA-----------------DAIERIMSSYKE 408
               ++T              I   L+T+ A                  A+E ++S Y  
Sbjct: 468 YAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPR 527

Query: 409 VTELAGYTARVHEMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVV 468
           V +  G + ++   F+  +   RC              SG +         PL + G V 
Sbjct: 528 VQKAVGSSEKI---FEYLDRTPRC------------PPSGLLT--------PLHLEGLVQ 564

Query: 469 DVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYG 528
             +      N P V     +V+  L   +  G    + GPNG GKS++  +L  L+   G
Sbjct: 565 FQDVSFAYPNRPDV-----LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTG 619

Query: 529 GVLY---KPPPQ--------RMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLE 577
           G L    KP PQ        ++  + Q P +   SL++ + Y  +    Q+    E    
Sbjct: 620 GQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLT----QKPTMEEITAA 675

Query: 578 AILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAV-- 635
           A+    H       +G    + +    LSGG++Q + +AR    +P   +LD+ TSA+  
Sbjct: 676 AVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDA 735

Query: 636 --SIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDG----EGG 678
              + VE  ++++ +    ++L IT   SL +   H+L  +G    EGG
Sbjct: 736 NSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGG 784


>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
            [Homo sapiens]
          Length = 1279

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 50/190 (26%), Positives = 90/190 (47%), Gaps = 22/190 (11%)

Query: 489  VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQ----------- 537
            V+  L++ V++G  L + G +GCGKS++ ++L   +    G +     +           
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRA 1110

Query: 538  RMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQR-EGGWE 596
            ++  + Q P +   S+ + + Y D+      +  S+ ++ +     ++H  ++     +E
Sbjct: 1111 QLGIVSQEPILFDCSIAENIAYGDN-----SRVVSQDEIVSAAKAANIHPFIETLPHKYE 1165

Query: 597  AMCDWKDV-LSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AGI 652
                 K   LSGG+KQRI +AR    +P+  LLDE TSA+  + E K+ Q A D    G 
Sbjct: 1166 TRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE-KVVQEALDKAREGR 1224

Query: 653  ALLSITHRPS 662
              + I HR S
Sbjct: 1225 TCIVIAHRLS 1234



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 52/191 (27%), Positives = 89/191 (46%), Gaps = 26/191 (13%)

Query: 489 VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPPQRMF------- 540
           ++  LN++V+ G  + + G +GCGKS+  +++  L+ P  G +       R F       
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470

Query: 541 ---YIPQRPYMSVGSLRDQVIYPD---SVEDMQRKGYSEQDLEAILDVVHLHHILQREGG 594
               + Q P +   ++ + + Y     +++++++        E I+ +      L  E G
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530

Query: 595 WEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AG 651
            +        LSGG+KQRI +AR     PK  LLDE TSA+  + E ++ QAA D    G
Sbjct: 531 AQ--------LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREG 581

Query: 652 IALLSITHRPS 662
              + I HR S
Sbjct: 582 RTTIVIAHRLS 592


>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
           [Homo sapiens]
          Length = 1286

 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 52/191 (27%), Positives = 89/191 (46%), Gaps = 26/191 (13%)

Query: 489 VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPPQRMF------- 540
           ++  LN++V+ G  + + G +GCGKS+  +++  L+ P  G +       R F       
Sbjct: 411 ILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLRE 470

Query: 541 ---YIPQRPYMSVGSLRDQVIYPD---SVEDMQRKGYSEQDLEAILDVVHLHHILQREGG 594
               + Q P +   ++ + + Y     +++++++        E I+ +      L  E G
Sbjct: 471 IIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERG 530

Query: 595 WEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AG 651
            +        LSGG+KQRI +AR     PK  LLDE TSA+  + E ++ QAA D    G
Sbjct: 531 AQ--------LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV-QAALDKAREG 581

Query: 652 IALLSITHRPS 662
              + I HR S
Sbjct: 582 RTTIVIAHRLS 592



 Score = 60.1 bits (144), Expect = 7e-09
 Identities = 52/197 (26%), Positives = 92/197 (46%), Gaps = 29/197 (14%)

Query: 489  VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLY--------------KP 534
            V+  L++ V++G  L + G +GCGKS++ ++L   +    G ++              K 
Sbjct: 1051 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKL 1110

Query: 535  PPQ----RMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQ 590
              Q    ++  + Q P +   S+ + + Y D+      +  S+ ++ +     ++H  ++
Sbjct: 1111 NVQWLRAQLGIVSQEPILFDCSIAENIAYGDN-----SRVVSQDEIVSAAKAANIHPFIE 1165

Query: 591  R-EGGWEAMCDWKDV-LSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAK 648
                 +E     K   LSGG+KQRI +AR    +P+  LLDE TSA+  + E K+ Q A 
Sbjct: 1166 TLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESE-KVVQEAL 1224

Query: 649  D---AGIALLSITHRPS 662
            D    G   + I HR S
Sbjct: 1225 DKAREGRTCIVIAHRLS 1241


>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
           [Homo sapiens]
          Length = 1545

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 52/160 (32%), Positives = 79/160 (49%), Gaps = 12/160 (7%)

Query: 487 EVVVASLNIRVEEGMHLLITGPNGCGKSSLFR-ILGGLWPTYGGVLYKPPPQRMFYIPQR 545
           E  V  +N+ +  G  + + GP G GKSSL   +LG +   +G +  K       Y+PQ+
Sbjct: 651 EATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHGHITIKGTTA---YVPQQ 707

Query: 546 PYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDV- 604
            ++  G+++D +++     +   K Y +Q LEA   +  L  +    GG  A    K + 
Sbjct: 708 SWIQNGTIKDNILFGT---EFNEKRY-QQVLEACALLPDLEML---PGGDLAEIGEKGIN 760

Query: 605 LSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIF 644
           LSGG+KQRI +AR  Y      LLD+  SAV   V   IF
Sbjct: 761 LSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIF 800



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 44/192 (22%), Positives = 84/192 (43%), Gaps = 23/192 (11%)

Query: 484  PSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVL-----------Y 532
            P  ++V+  +   +     + + G  G GKSSL   L  +    GG +            
Sbjct: 1311 PELDLVLRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGL 1370

Query: 533  KPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQ-- 590
                +++  IPQ P +  GSLR  +   D   +     YS++++   L++ HL   +   
Sbjct: 1371 HDLREKLTIIPQDPILFSGSLRMNL---DPFNN-----YSDEEIWKALELAHLKSFVASL 1422

Query: 591  REGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD- 649
            + G    + +    LS G++Q + + R    + K  +LDE T+AV ++ +  I    ++ 
Sbjct: 1423 QLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNE 1482

Query: 650  -AGIALLSITHR 660
             A   +++I HR
Sbjct: 1483 FAHCTVITIAHR 1494


>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
           sapiens]
          Length = 753

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 57/214 (26%), Positives = 98/214 (45%), Gaps = 16/214 (7%)

Query: 460 PLKIRGQVVDVEQGIICENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRI 519
           PL+I  Q   V      +N+      G+ V++ ++  V  G  + I G +G GKS++ R+
Sbjct: 463 PLQITPQTATVA----FDNVHFEYIEGQKVLSGISFEVPAGKKVAIVGGSGSGKSTIVRL 518

Query: 520 LGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVGSL-RDQVIYPDSVEDMQRKGY---SEQD 575
           L   +    G +Y           +    +VG + +D V++ +++      G    S ++
Sbjct: 519 LFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEE 578

Query: 576 LEAILDVVHLHH-ILQREGGWEAMCDWKDV-LSGGEKQRIGMARMFYHRPKYALLDECTS 633
           + A+  +  LH  IL+   G++     + + LSGGEKQR+ +AR     P   L DE TS
Sbjct: 579 VYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATS 638

Query: 634 AVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYH 667
           ++    E  I  A KD       + HR S++  H
Sbjct: 639 SLDSITEETILGAMKDV------VKHRTSIFIAH 666


>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
           sapiens]
          Length = 1581

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 72/262 (27%), Positives = 111/262 (42%), Gaps = 40/262 (15%)

Query: 483 TPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLF-RILGGLWPTYGGVLYK-------- 533
           TP G   ++++ IR+  G   +I G  GCGKSSL    LG +    G V +         
Sbjct: 689 TPDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIG 748

Query: 534 --PPPQR-------------MFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQ-DLE 577
             P P+R             + Y  Q+P++   ++ + +I+       + K   E   L+
Sbjct: 749 EDPSPERETATDLDIRKRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQ 808

Query: 578 AILDVVHLHHILQREGGWEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSI 637
             +D+  L H  Q + G   +      LSGG++QRI +AR  Y       LD+  SA+ I
Sbjct: 809 PDIDI--LPHGDQTQIGERGIN-----LSGGQRQRISVARALYQHANVVFLDDPFSALDI 861

Query: 638 DVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLD-SAARLSLTEEK 696
            +   + Q    AGI  L    + ++    TH LQ+     W     D +  R    ++ 
Sbjct: 862 HLSDHLMQ----AGILELLRDDKRTV-VLVTHKLQYLPHADWIIAMKDGTIQREGTLKDF 916

Query: 697 QRLEQQLAGIPK--MQRRLQEL 716
           QR E QL    K  M R+ QEL
Sbjct: 917 QRSECQLFEHWKTLMNRQDQEL 938



 Score = 36.6 bits (83), Expect = 0.087
 Identities = 46/188 (24%), Positives = 83/188 (44%), Gaps = 25/188 (13%)

Query: 489  VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLY-------KPP----PQ 537
            V+  +N  +  G  + I G  G GKSS       +  T+ G +        K P      
Sbjct: 1360 VLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRS 1419

Query: 538  RMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQR-EGGWE 596
            R+  I Q P +  G++R  +       D +RK  S+  L   L++  L  +++   GG +
Sbjct: 1420 RLSIILQDPVLFSGTIRFNL-------DPERK-CSDSTLWEALEIAQLKLVVKALPGGLD 1471

Query: 597  AMC-DWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEG---KIFQAAKDAGI 652
            A+  +  +  S G++Q   +AR F  +    ++DE T+++ +  E    K+   A  A  
Sbjct: 1472 AIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTA-FADR 1530

Query: 653  ALLSITHR 660
             +++I HR
Sbjct: 1531 TVVTIAHR 1538


>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
           [Homo sapiens]
          Length = 1527

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 50/154 (32%), Positives = 79/154 (51%), Gaps = 10/154 (6%)

Query: 492 SLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVG 551
           SL+I+V +G  + + GP GCGKSSL   L G      G ++      + Y+PQ+ ++   
Sbjct: 646 SLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS--VAYVPQQAWIQNC 703

Query: 552 SLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDV-LSGGEK 610
           +L++ V++  ++     K Y +Q LEA   +  L  +    GG +     K + LSGG++
Sbjct: 704 TLQENVLFGKALNP---KRY-QQTLEACALLADLEML---PGGDQTEIGEKGINLSGGQR 756

Query: 611 QRIGMARMFYHRPKYALLDECTSAVSIDVEGKIF 644
           QR+ +AR  Y      LLD+  SAV   V   IF
Sbjct: 757 QRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIF 790



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 56/208 (26%), Positives = 95/208 (45%), Gaps = 27/208 (12%)

Query: 484  PSGEVVVASLNIRVEEGMHLLITGPNGCGKSS----LFRIL---------GGLWPTYGGV 530
            P  ++V+  L++ V  G  + I G  G GKSS    LFRIL          GL      +
Sbjct: 1300 PGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGL--NVADI 1357

Query: 531  LYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQ 590
                   ++  IPQ P +  G+LR  +    S        YSE+D+   L++ HLH  + 
Sbjct: 1358 GLHDLRSQLTIIPQDPILFSGTLRMNLDPFGS--------YSEEDIWWALELSHLHTFVS 1409

Query: 591  RE-GGWEAMC-DWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAK 648
             +  G +  C +  + LS G++Q + +AR    + +  +LDE T+A+ ++ +  I    +
Sbjct: 1410 SQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIR 1469

Query: 649  DA--GIALLSITHRPSLWKYHTHLLQFD 674
                   +L+I HR +    +T +L  D
Sbjct: 1470 TQFDTCTVLTIAHRLNTIMDYTRVLVLD 1497


>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
           sapiens]
          Length = 842

 Score = 61.2 bits (147), Expect = 3e-09
 Identities = 50/174 (28%), Positives = 81/174 (46%), Gaps = 8/174 (4%)

Query: 477 ENIPIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPP 536
           EN+      G   +  ++  V  G  L + GP+G GKS++ R+L   +    G + +   
Sbjct: 593 ENVHFSYADGRETLQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGCI-RIDG 651

Query: 537 QRMFYIPQRPYMS-VGSL-RDQVIYPDSVEDMQRKGY---SEQDLEAILDVVHLHH-ILQ 590
           Q +  + Q    S +G + +D V++ D++ D  R G       ++EA      +H  I+ 
Sbjct: 652 QDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIHDAIMA 711

Query: 591 REGGWEAMCDWKDV-LSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKI 643
              G+      + + LSGGEKQR+ +AR     P   LLDE TSA+    E  I
Sbjct: 712 FPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAI 765


>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
           isoform 1 [Homo sapiens]
          Length = 703

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 64/242 (26%), Positives = 104/242 (42%), Gaps = 38/242 (15%)

Query: 489 VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPP----------Q 537
           V+  L   +  G    + GPNG GKS++  +L  L+ PT G VL    P           
Sbjct: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHS 544

Query: 538 RMFYIPQRPYMSVGSLRDQVIYP-DSVEDMQRKGYSEQDLEAILDVVHLHHILQR--EGG 594
           ++  + Q P +  GS+R+ + Y   S ED          + A     H    +Q    G 
Sbjct: 545 QVVSVGQEPVLFSGSVRNNIAYGLQSCED--------DKVMAAAQAAHADDFIQEMEHGI 596

Query: 595 WEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIAL 654
           +  + +    L+ G+KQR+ +AR     P+  +LDE TSA+ +  E  +          +
Sbjct: 597 YTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTV 656

Query: 655 LSITHR-PSLWKYHTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAGIPKMQRRL 713
           L I HR  ++ + H  L+  +G       KL   A+L   +E Q L  +L     +Q+RL
Sbjct: 657 LVIAHRLQAVQRAHQILVLQEG-------KLQKLAQL---QEGQDLYSRL-----VQQRL 701

Query: 714 QE 715
            +
Sbjct: 702 MD 703


>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1312

 Score = 57.8 bits (138), Expect = 4e-08
 Identities = 124/563 (22%), Positives = 220/563 (39%), Gaps = 90/563 (15%)

Query: 126 DPRAFGWQ-----LLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTY 180
           DP+   W+     +L +L   L   F    +  L+  L +  RS +    YR   +  + 
Sbjct: 150 DPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK-VLQMRLRSAITGLVYRKVLALSSG 208

Query: 181 YRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGT 240
            R ++  G + N    ++ DV     SV +L + L  PL+ + V    L +         
Sbjct: 209 SRKASAVGDVVN---LVSVDVQRLTESVLYL-NGLWLPLVWIVVCFVYLWQLLG------ 258

Query: 241 AWPSAIAGLVVFLTANVLRAF-SPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGH 299
             PSA+  + VFL+   L  F S K      E+ R+K     + S ++ NS+ I F+G  
Sbjct: 259 --PSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGW- 315

Query: 300 EVELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSE 359
             E A L R       ++  +    L + +    L+ +  S   + +V   + T    + 
Sbjct: 316 --EGAFLDRVLGIRGQELGALRTSGLLFSVS---LVSFQVSTFLVALVVFAVHTLVAENA 370

Query: 360 SDAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARV 419
            +AE   KA +      ++++       + + L  A  + +R+++               
Sbjct: 371 MNAE---KAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVT--------------- 412

Query: 420 HEMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENI 479
              F   E+V       P  ++ + +GS   G+  + ++       Q          E+ 
Sbjct: 413 ---FLCLEEVD------PGAVDSSSSGSAA-GKDCITIQSATFAWSQ----------ESP 452

Query: 480 PIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFR-ILGGLWPTYGGVLYKPPPQR 538
           P +          +N+ V +G  L + GP G GKSSL   +LG L    G V  +     
Sbjct: 453 PCLH--------RINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA--- 501

Query: 539 MFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQR--EGGWE 596
           + Y+PQ  ++   S+ + V +   ++           LE +L+   L   +    EG   
Sbjct: 502 VAYVPQEAWVQNTSVVENVCFGQELDPPW--------LERVLEACALQPDVDSFPEGIHT 553

Query: 597 AMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLS 656
           ++ +    LSGG+KQR+ +AR  Y +    LLD+  +A+   V   +F      G  LL 
Sbjct: 554 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPG-GLLQ 612

Query: 657 ITHRPSLWKYHTHLLQFDGEGGW 679
            T R  +    TH L    +  W
Sbjct: 613 GTTRILV----THALHILPQADW 631



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 52/192 (27%), Positives = 87/192 (45%), Gaps = 23/192 (11%)

Query: 484  PSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRIL--------GGLW---PTYGGVLY 532
            P   + V  ++ ++  G  + I G  G GKSSL   L        GG+W        V  
Sbjct: 1085 PELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGL 1144

Query: 533  KPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQR- 591
                 R+  IPQ P +  GSLR  +   D +++     +S++ + A L+ V L  ++   
Sbjct: 1145 HTLRSRISIIPQDPILFPGSLRMNL---DLLQE-----HSDEAIWAALETVQLKALVASL 1196

Query: 592  EGGWEAMC-DWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAV--SIDVEGKIFQAAK 648
             G  +  C D  + LS G+KQ + +AR    + +  +LDE T+AV    +++ +    + 
Sbjct: 1197 PGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSW 1256

Query: 649  DAGIALLSITHR 660
             A   +L I HR
Sbjct: 1257 FAQCTVLLIAHR 1268


>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
           isoform 2 [Homo sapiens]
          Length = 653

 Score = 57.4 bits (137), Expect = 5e-08
 Identities = 46/166 (27%), Positives = 73/166 (43%), Gaps = 22/166 (13%)

Query: 489 VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPP----------Q 537
           V+  L   +  G    + GPNG GKS++  +L  L+ PT G VL    P           
Sbjct: 485 VLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHS 544

Query: 538 RMFYIPQRPYMSVGSLRDQVIYP-DSVEDMQRKGYSEQDLEAILDVVHLHHILQR--EGG 594
           ++  + Q P +  GS+R+ + Y   S ED          + A     H    +Q    G 
Sbjct: 545 QVVSVGQEPVLFSGSVRNNIAYGLQSCED--------DKVMAAAQAAHADDFIQEMEHGI 596

Query: 595 WEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVE 640
           +  + +    L+ G+KQR+ +AR     P+  +LDE TSA+ +  E
Sbjct: 597 YTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642


>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
            [Homo sapiens]
          Length = 1321

 Score = 57.0 bits (136), Expect = 6e-08
 Identities = 54/190 (28%), Positives = 82/190 (43%), Gaps = 22/190 (11%)

Query: 489  VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPPQRMF------- 540
            V+  L++ +  G  L   G +GCGKS+  ++L   + P  G V+      +         
Sbjct: 1095 VLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQFLRS 1154

Query: 541  ---YIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILD--VVHLHHILQREGGW 595
                + Q P +   S+ D + Y D+ +++  +       +A L   V+ L    +   G 
Sbjct: 1155 NIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYETNVGS 1214

Query: 596  EAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AGI 652
            +        LS GEKQRI +AR     PK  LLDE TSA+  + E K  Q A D    G 
Sbjct: 1215 QG-----SQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESE-KTVQVALDKAREGR 1268

Query: 653  ALLSITHRPS 662
              + I HR S
Sbjct: 1269 TCIVIAHRLS 1278



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 48/202 (23%), Positives = 87/202 (43%), Gaps = 24/202 (11%)

Query: 489 VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPPQRMFYIP---- 543
           ++  LN+ ++ G    + GP+G GKS+  +++   + P  G V       R   I     
Sbjct: 437 ILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRD 496

Query: 544 ------QRPYMSVGSLRDQVIY---PDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGG 594
                 Q P +   ++ + + Y     ++ED+ +          I+D+      L  EGG
Sbjct: 497 QIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGG 556

Query: 595 WEAMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAK--DAGI 652
            +        +SGG+KQR+ +AR     PK  LLD  TSA+  + E  + +       G 
Sbjct: 557 GQ--------MSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGH 608

Query: 653 ALLSITHRPSLWKYHTHLLQFD 674
            ++S+ HR S  +    ++ F+
Sbjct: 609 TIISVAHRLSTVRAADTIIGFE 630


>gi|90421313 cystic fibrosis transmembrane conductance regulator
           [Homo sapiens]
          Length = 1480

 Score = 56.6 bits (135), Expect = 8e-08
 Identities = 44/164 (26%), Positives = 79/164 (48%), Gaps = 14/164 (8%)

Query: 486 GEVVVASLNIRVEEGMHLLITGPNGCGKSSLFR-ILGGLWPTYGGVLYKPPPQRMFYIPQ 544
           G  V+  +N ++E G  L + G  G GK+SL   I+G L P+ G + +     R+ +  Q
Sbjct: 437 GTPVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIKHS---GRISFCSQ 493

Query: 545 RPYMSVGSLRDQVIYPDSVEDMQRKGYSE--QDLEAILDVVHLHHILQREGGWEAMCDWK 602
             ++  G++++ +I+  S ++ + +   +  Q  E I       +I+  EGG        
Sbjct: 494 FSWIMPGTIKENIIFGVSYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG-------- 545

Query: 603 DVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQA 646
             LSGG++ RI +AR  Y      LLD     + +  E +IF++
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIFES 589



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 41/160 (25%), Positives = 71/160 (44%), Gaps = 20/160 (12%)

Query: 483  TPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYG-----GVLYKPPPQ 537
            T  G  ++ +++  +  G  + + G  G GKS+L      L  T G     GV +     
Sbjct: 1220 TEGGNAILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRLLNTEGEIQIDGVSWDSITL 1279

Query: 538  RMF-----YIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQRE 592
            + +      IPQ+ ++  G+ R  +   D  E      +S+Q++  + D V L  ++++ 
Sbjct: 1280 QQWRKAFGVIPQKVFIFSGTFRKNL---DPYEQ-----WSDQEIWKVADEVGLRSVIEQF 1331

Query: 593  GGWE--AMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDE 630
             G     + D   VLS G KQ + +AR    + K  LLDE
Sbjct: 1332 PGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDE 1371


>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
           [Homo sapiens]
          Length = 1503

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 124/563 (22%), Positives = 218/563 (38%), Gaps = 90/563 (15%)

Query: 126 DPRAFGWQ-----LLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQTY 180
           DP+   W+     +L +L   L   F    +  L+  L +  RS +    YR   +  + 
Sbjct: 341 DPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLK-VLQMRLRSAITGLVYRKVLALSSG 399

Query: 181 YRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGT 240
            R ++  G + N    ++ DV     SV +L + L  PL+ + V    L +         
Sbjct: 400 SRKASAVGDVVN---LVSVDVQRLTESVLYL-NGLWLPLVWIVVCFVYLWQLLG------ 449

Query: 241 AWPSAIAGLVVFLTANVLRAF-SPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGH 299
             PSA+  + VFL+   L  F S K      E+ R+K     + S ++ NS+ I F   H
Sbjct: 450 --PSALTAIAVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKF---H 504

Query: 300 EVELALLQRSYQDLASQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYSE 359
             E A L R       ++  +    L + +    L+ +  S   + +V   + T    + 
Sbjct: 505 GWEGAFLDRVLGIRGQELGALRTSGLLFSVS---LVSFQVSTFLVALVVFAVHTLVAENA 561

Query: 360 SDAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYTARV 419
            +AE   KA +      ++++       + + L  A  + +R+++               
Sbjct: 562 MNAE---KAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVT--------------- 603

Query: 420 HEMFQVFEDVQRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQGIICENI 479
              F   E+V       P  ++ + +GS   G+  + +        Q          E+ 
Sbjct: 604 ---FLCLEEVD------PGVVDSSSSGSAA-GKDCITIHSATFAWSQ----------ESP 643

Query: 480 PIVTPSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFR-ILGGLWPTYGGVLYKPPPQR 538
           P +          +N+ V +G  L + GP G GKSSL   +LG L    G V  +     
Sbjct: 644 PCLH--------RINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA--- 692

Query: 539 MFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQR--EGGWE 596
           + Y+PQ  ++   S+ + V +   ++           LE +L+   L   +    EG   
Sbjct: 693 VAYVPQEAWVQNTSVVENVCFGQELDPPW--------LERVLEACALQPDVDSFPEGIHT 744

Query: 597 AMCDWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLS 656
           ++ +    LSGG+KQR+ +AR  Y +    LLD+  +A+   V   +F      G  LL 
Sbjct: 745 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPG-GLLQ 803

Query: 657 ITHRPSLWKYHTHLLQFDGEGGW 679
            T R  +    TH L    +  W
Sbjct: 804 GTTRILV----THALHILPQADW 822



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 52/192 (27%), Positives = 87/192 (45%), Gaps = 23/192 (11%)

Query: 484  PSGEVVVASLNIRVEEGMHLLITGPNGCGKSSLFRIL--------GGLW---PTYGGVLY 532
            P   + V  ++ ++  G  + I G  G GKSSL   L        GG+W        V  
Sbjct: 1276 PELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGL 1335

Query: 533  KPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQR- 591
                 R+  IPQ P +  GSLR  +   D +++     +S++ + A L+ V L  ++   
Sbjct: 1336 HTLRSRISIIPQDPILFPGSLRMNL---DLLQE-----HSDEAIWAALETVQLKALVASL 1387

Query: 592  EGGWEAMC-DWKDVLSGGEKQRIGMARMFYHRPKYALLDECTSAV--SIDVEGKIFQAAK 648
             G  +  C D  + LS G+KQ + +AR    + +  +LDE T+AV    +++ +    + 
Sbjct: 1388 PGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSW 1447

Query: 649  DAGIALLSITHR 660
             A   +L I HR
Sbjct: 1448 FAQCTVLLIAHR 1459


>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
           sapiens]
          Length = 1464

 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 48/170 (28%), Positives = 78/170 (45%), Gaps = 14/170 (8%)

Query: 494 NIRVEEGMHLLITGPNGCGKSSLFRILGG-LWPTYGGVLYKPPPQRMFYIPQRPYMSVGS 552
           ++ V++GM + I G  GCGKSSL   + G L    G V  +   +      Q P++   +
Sbjct: 592 HLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFAT 651

Query: 553 LRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQ-REGGWEAMCDWKDV-LSGGEK 610
           +RD +++         K +  Q  + +L+   L+  L     G +     K V LSGG++
Sbjct: 652 IRDNILFG--------KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQR 703

Query: 611 QRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDAGIALLSITHR 660
            RI +AR  Y   +  LLD+  +AV  DV   +        + +LS T R
Sbjct: 704 ARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCI---LGMLSYTTR 750



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 48/179 (26%), Positives = 80/179 (44%), Gaps = 24/179 (13%)

Query: 497  VEEGMHLLITGPNGCGKSSLFRILGGLW-PTYGGVLYKPPP----------QRMFYIPQR 545
            V+ G  L I G  G GKSSL  +L  L  P+ G VL                ++  IPQ 
Sbjct: 1242 VQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQE 1301

Query: 546  PYMSVGSLRDQVIYPDSVEDMQRKG-YSEQDLEAILDVVHLHHILQREGGWEA-MCDWKD 603
            P++  G++R         E++  +G + ++ L   L   HL  ++   GG +  + +   
Sbjct: 1302 PFLFSGTVR---------ENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGR 1352

Query: 604  VLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQ--AAKDAGIALLSITHR 660
             LS G++Q + +AR      K   +DE T++V    +  + Q    + A   +L+I HR
Sbjct: 1353 SLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHR 1411


>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
           sapiens]
          Length = 738

 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 51/197 (25%), Positives = 87/197 (44%), Gaps = 29/197 (14%)

Query: 489 VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGGVLYKPPPQ----------- 537
           +    ++ +  G    + GP+G GKS++  +L  L+    G +                 
Sbjct: 509 IFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRS 568

Query: 538 RMFYIPQRPYMSVGSLRDQVIY----PDSVEDMQRKGYSEQDLEAILDVVHLHHILQR-E 592
           ++  + Q P +   S+ + + Y    P SV        + ++++ + +V +    ++   
Sbjct: 569 KIGTVSQEPILFSCSIAENIAYGADDPSSV--------TAEEIQRVAEVANAVAFIRNFP 620

Query: 593 GGWEAMCDWKDVL-SGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKDA- 650
            G+  +   K VL SGG+KQRI +AR     PK  LLDE TSA+  + E  + Q A D  
Sbjct: 621 QGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENE-YLVQEALDRL 679

Query: 651 --GIALLSITHRPSLWK 665
             G  +L I HR S  K
Sbjct: 680 MDGRTVLVIAHRLSTIK 696


>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
           [Homo sapiens]
          Length = 1344

 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 65/265 (24%), Positives = 113/265 (42%), Gaps = 48/265 (18%)

Query: 493 LNIRVEEGMHLLITGPNGCGKSSLFR-ILGGLWPTYGGVLYKPPPQRMFYIPQRPYMSVG 551
           +N+ V +GM L + G  G GKSSL   IL  +    G V  +     + Y+PQ+ ++  G
Sbjct: 530 INLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS---LAYVPQQAWIVSG 586

Query: 552 SLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHILQREGGWEAMCDWKDV------L 605
           ++R+ ++   +            D    L V+H    L R+       D  ++      L
Sbjct: 587 NIRENILMGGAY-----------DKARYLQVLHCCS-LNRDLELLPFGDMTEIGERGLNL 634

Query: 606 SGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQAAKD---AGIALLSITHRPS 662
           SGG+KQRI +AR  Y   +  LLD+  SAV   V   IF+        G  ++ +TH+  
Sbjct: 635 SGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQ 694

Query: 663 LWKY-----------------HTHLLQFDGEGGWKFEKLDSAARLSLTEEKQRLEQQLAG 705
             ++                 H+ L+Q  G+     +K+   A   + ++  ++ ++   
Sbjct: 695 YLEFCGQIILLENGKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEK--- 751

Query: 706 IPKMQRRLQELCQILGEAVAPAHVP 730
            PK++   Q L   L E++    VP
Sbjct: 752 -PKVES--QALATSLEESLNGNAVP 773


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.136    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,513,496
Number of Sequences: 37866
Number of extensions: 1224480
Number of successful extensions: 4716
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 22
Number of HSP's that attempted gapping in prelim test: 4485
Number of HSP's gapped (non-prelim): 168
length of query: 745
length of database: 18,247,518
effective HSP length: 110
effective length of query: 635
effective length of database: 14,082,258
effective search space: 8942233830
effective search space used: 8942233830
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.