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Search of human proteins with 6912446
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912446 potassium voltage-gated channel, subfamily H, member
4 [Homo sapiens]
(1017 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 2060 0.0
gi|27886667 potassium voltage-gated channel, subfamily H, member... 1055 0.0
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 919 0.0
gi|13540549 potassium voltage-gated channel, subfamily H, member... 593 e-169
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 503 e-142
gi|27437001 potassium voltage-gated channel, subfamily H, member... 493 e-139
gi|22024390 potassium voltage-gated channel, subfamily H, member... 491 e-138
gi|26051273 voltage-gated potassium channel, subfamily H, member... 478 e-135
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 478 e-135
gi|27886651 potassium voltage-gated channel, subfamily H, member... 469 e-132
gi|27886646 potassium voltage-gated channel, subfamily H, member... 463 e-130
gi|27886653 potassium voltage-gated channel, subfamily H, member... 454 e-127
gi|27886648 potassium voltage-gated channel, subfamily H, member... 437 e-122
gi|26051271 voltage-gated potassium channel, subfamily H, member... 422 e-118
gi|27886665 potassium voltage-gated channel, subfamily H, member... 330 4e-90
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 169 9e-42
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 167 6e-41
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 165 2e-40
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 163 9e-40
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 153 9e-37
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 153 9e-37
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 146 8e-35
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 146 8e-35
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 132 2e-30
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 130 8e-30
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 112 2e-24
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 87 6e-17
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi... 60 1e-08
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi... 59 2e-08
gi|14602439 Williams Beuren syndrome chromosome region 14 isofor... 52 2e-06
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 2060 bits (5337), Expect = 0.0
Identities = 1017/1017 (100%), Positives = 1017/1017 (100%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV
Sbjct: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM
Sbjct: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
Query: 121 GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT 180
GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT
Sbjct: 121 GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT 180
Query: 181 GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV 240
GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV
Sbjct: 181 GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV 240
Query: 241 AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI 300
AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI
Sbjct: 241 AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI 300
Query: 301 GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV 360
GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV
Sbjct: 301 GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV 360
Query: 361 VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGP 420
VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGP
Sbjct: 361 VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGP 420
Query: 421 SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQR 480
SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQR
Sbjct: 421 SRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQR 480
Query: 481 MYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELR 540
MYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELR
Sbjct: 481 MYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELR 540
Query: 541 ADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGS 600
ADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGS
Sbjct: 541 ADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGS 600
Query: 601 LEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSR 660
LEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSR
Sbjct: 601 LEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSR 660
Query: 661 GLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDK 720
GLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDK
Sbjct: 661 GLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDK 720
Query: 721 TLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSP 780
TLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSP
Sbjct: 721 TLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSP 780
Query: 781 SLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEA 840
SLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEA
Sbjct: 781 SLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEA 840
Query: 841 PSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRE 900
PSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRE
Sbjct: 841 PSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRE 900
Query: 901 LRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPA 960
LRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPA
Sbjct: 901 LRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPA 960
Query: 961 SVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH 1017
SVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH
Sbjct: 961 SVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPPTPSLLRHSFQSRSDTFH 1017
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 1055 bits (2728), Expect = 0.0
Identities = 588/1027 (57%), Positives = 703/1027 (68%), Gaps = 59/1027 (5%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
MPVMKGLLAPQNTFLDTIATRFDGTHSNF+LANAQ +GFPIVYCSDGFCEL G+ RTEV
Sbjct: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQK+CSC+FL+G ET+E + ++ K+LE E + EI FY+K+GS FWCLLD++PIKNE
Sbjct: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
Query: 121 GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT 180
G+VVLFL SFKDIT + + P+ D + GR A F SARRRSR VL+ ++
Sbjct: 121 GDVVLFLASFKDITDT-KVKITPE----DKKEDKVKGRSRAGTHFDSARRRSRAVLYHIS 175
Query: 181 GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV 240
GH RR + +K NNNVF KP+ PEYKV+ S+ +LLH+S KA WD LILLATFYV
Sbjct: 176 GHLQRREKNKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYV 235
Query: 241 AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI 300
AVTVPYNVCF G+DD T+R T VSDIAVE+LFI+DIILNFRTTYVS+SGQVI RSI
Sbjct: 236 AVTVPYNVCFIGNDDLS-TTRSTTVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSI 294
Query: 301 GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV 360
+HY+ TWF IDLIAALPFDLLY FN+TV SLVHLLKTVRLLRLLRLLQKL+RYSQ S +
Sbjct: 295 CIHYVTTWFIIDLIAALPFDLLYAFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTI 354
Query: 361 VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYV-NGSVGG 419
VLTLLMS+FALLAHWMACIWYVIG+ E E N L W++GWLHELGKRLE PY N ++GG
Sbjct: 355 VLTLLMSMFALLAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGG 414
Query: 420 PSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQ 479
PS RSAYIAALYFTLSSLTSVGFGNV ANTDAEKIFSICTMLIGALMHA+VFGNVTAIIQ
Sbjct: 415 PSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQ 474
Query: 480 RMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDEL 539
RMYSR SLYH+R KDLKDFIRVH LP+ LKQRMLEYFQTTW+VN+GID+NELL+DFPDEL
Sbjct: 475 RMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDEL 534
Query: 540 RADIAMHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSG 599
R+DI MHLN+EILQL LF ASRGCLR+LSLHIKTSFCAPGEYLLR+GDALQA Y+VCSG
Sbjct: 535 RSDITMHLNKEILQLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSG 594
Query: 600 SLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSS 659
S+EVL+D+MVLAILGKGDLIGA++ Q V+KT+ADVKALTYC LQ +
Sbjct: 595 SMEVLKDSMVLAILGKGDLIGANLSIKDQ----------VIKTNADVKALTYCDLQCIIL 644
Query: 660 RGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSD 719
+GL EVL LYPEY F + DLT+NLR+G ++ +SR S +SQ + G + +
Sbjct: 645 KGLFEVLDLYPEYAHKFVEDIQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNG-NIN 703
Query: 720 KTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRG-----------------SLVSLL 762
K LPSI E E E G +LSP RG SL L
Sbjct: 704 KRLPSIVEDEEEEEEGEEEE------AVSLSPICTRGSSSRNKKVGSNKAYLGLSLKQLA 757
Query: 763 GEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPD 822
+P S + S S SP + H+ K +L + L GPPD
Sbjct: 758 SGTVPFHSPIRVSRSNSPKTKQEIDPPNHNKRKE---------KNLKLQLSTLNNAGPPD 808
Query: 823 LSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELAS-----EAEEVK 877
LSPRIVDGIED S+ E+ +F F PR +PP G PE+ + +AEE K
Sbjct: 809 LSPRIVDGIEDGNSSEESQTFDFGSERIRSEPRI-SPPLG---DPEIGAAVLFIKAEETK 864
Query: 878 EKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCL 937
+++ +LN E++ L QEVSQL +++R+++ LL+ L P + CP
Sbjct: 865 QQINKLNSEVTTLTQEVSQLGKDMRNVIQLLENVLSPQQPSRFCSLHSTSVCPSRESLQT 924
Query: 938 SPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEA 997
S P L T + A + + + + + PS + P +P
Sbjct: 925 RTSWSAHQPCLHLQTGGAAYTQAQLCSSNITSDIWSVDPSSVGSSPQRTGAHEQNPADSE 984
Query: 998 SPPTPSL 1004
+PSL
Sbjct: 985 LYHSPSL 991
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 919 bits (2374), Expect = 0.0
Identities = 528/1040 (50%), Positives = 658/1040 (63%), Gaps = 95/1040 (9%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
MP M+GLLAPQNTFLDTIATRFDGTHSNF+L NAQ FP+VYCSDGFC+LTG+ R EV
Sbjct: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQ+ C+C FLYGP+TSE Q++ KAL+ H+E +AE+ YRK G FWCLLD++PIKNE
Sbjct: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
Query: 121 GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT 180
GEV LFL S KDI+++ + G GP + GR + F + RRRSR VL+ L+
Sbjct: 121 GEVALFLVSHKDISETKNRG-GPDRWKETGGGRRRYGRARSKG-FNANRRRSRAVLYHLS 178
Query: 181 GHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYV 240
GH ++ +G K N VF KP++PEYKVA++ S +LLH +A WDG ILLAT YV
Sbjct: 179 GHLQKQPKGKHKLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYV 238
Query: 241 AVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSI 300
AVTVPY+VC S + V D+AVE+LFILDI+LNFRTT+VS+SGQV+ AP+SI
Sbjct: 239 AVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSI 298
Query: 301 GLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAV 360
LHY+ TWF +D+IAALPFDLL+ F + V HLLKTVRLLRLLRLL +L+RYSQ SAV
Sbjct: 299 CLHYVTTWFLLDVIAALPFDLLHAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAV 358
Query: 361 VLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPY-------- 412
VLTLLM+VFALLAHW+AC+W+ IG+RE+E+++ L +IGWL EL +RLE PY
Sbjct: 359 VLTLLMAVFALLAHWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPA 418
Query: 413 ----------------VNGS----VGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAE 452
NG+ +GGPS RSAYI +LYF LSSLTSVGFGNV ANTD E
Sbjct: 419 GGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTE 478
Query: 453 KIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRM 512
KIFSICTMLIGALMHAVVFGNVTAIIQRMY+RR LYHSR +DL+D+IR+HR+P+PLKQRM
Sbjct: 479 KIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRM 538
Query: 513 LEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQLPLFGAASRGCLRALSLHI 572
LEYFQ TWAVN+GID ELL+ PDELRADIAMHL++E+LQLPLF AASRGCLRALSL +
Sbjct: 539 LEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVLQLPLFEAASRGCLRALSLAL 598
Query: 573 KTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGL 632
+ +FC PGEYL+ +GDALQA Y+VCSGS+EVL+ VLAILGKGDLIG ++P Q
Sbjct: 599 RPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQ---- 654
Query: 633 GADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGS 692
V+K +ADVK LTYC LQ L GL + L LYPE+ F GL +L++NL G
Sbjct: 655 ------VVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGG 708
Query: 693 DTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSI-----TEAESG--AEPGGGPRPRRPLL 745
++ + ++ S D TL S T+ E G P P PLL
Sbjct: 709 GSAEV--------------DTSSLSGDNTLMSTLEEKETDGEQGPTVSPAPADEPSSPLL 754
Query: 746 LPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQ-GHSASPHGPPRCSAA 804
P + + L+S P +A P L P AG A P PPR
Sbjct: 755 SPGCTSSSSAAKLLS------PRRTA--PRPRLGGRGRPGRAGALKAEAGPSAPPRALEG 806
Query: 805 WKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRF---SRRPELPRPRSQAPPT 861
L +PP+ PPDLSPR+VDGIED G ++ P F F PE S P +
Sbjct: 807 -----LRLPPMPWNVPPDLSPRVVDGIED-GCGSDQPKFSFRVGQSGPECSSSPSPGPES 860
Query: 862 GTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGS 921
G P SEA + + +L Q ++ L+++V Q+ L+ + +Q L P H G
Sbjct: 861 GLLTVPHGPSEARNT-DTLDKLRQAVTELSEQVLQMREGLQSLRQAVQLVLAP--HREG- 916
Query: 922 AWTPDPPCPQL--RPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSIL 979
PCP+ PC + + P DT + G++ +GT P
Sbjct: 917 ------PCPRASGEGPCPASTSGLLQPLCVDTGASSYCLQPPAGSVLSGTW---PHPRPG 967
Query: 980 PPYPSEPDPLGPSPVPEASP 999
PP P P GP P ++SP
Sbjct: 968 PPPLMAPWPWGP-PASQSSP 986
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 593 bits (1529), Expect = e-169
Identities = 362/845 (42%), Positives = 489/845 (57%), Gaps = 79/845 (9%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
MPV +G +APQNT+LDTI +F+G FL+ANAQ I+YC+DGFCEL GY R EV
Sbjct: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQ-MENCAIIYCNDGFCELFGYSRVEV 59
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQ+ C+C FL GP T A+ RL +AL G +E + +I +YRKD S+F CL+D++P+KNE
Sbjct: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
Query: 121 GEVVLFLFSFKDITQ-------------------------SGSPG-LGPQGGRGDSNHEN 154
G V++F+ +F+D+ Q G PG GP GRG +
Sbjct: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
Query: 155 SLGR---RGATWKFRSARRRSRTVLHRLTGH-FGRRGQGGMKANNNVFEPKPSV-PEYKV 209
+ + + R S T + + H R Q + V V PEYK+
Sbjct: 180 QIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKL 239
Query: 210 ASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF--SGDDDT-----PITSRH 262
+ R +LHYS KA+WD LILL Y AV PY+ F S D++ T
Sbjct: 240 QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSP 299
Query: 263 TLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLL 322
V D+ V+++F++DI++NFRTTYV+ + +V+S PR I +HY WF ID++AA+PFDLL
Sbjct: 300 LTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL 359
Query: 323 YIFNI---TVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACI 379
IF T+L+ LLKT RLLRL+R+ +KL+RYS+ A VL LLM FAL+AHW+ACI
Sbjct: 360 -IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI 418
Query: 380 WYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGS--VGGPSRRSAYIAALYFTLSSL 437
WY IG E L IGWL LG +L Y NGS GPS + Y+ ALYFT SSL
Sbjct: 419 WYAIGNVERPY---LEHKIGWLDSLGVQLGKRY-NGSDPASGPSVQDKYVTALYFTFSSL 474
Query: 438 TSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKD 497
TSVGFGNV NT++EK+FSIC MLIG+LM+A +FGNV+AIIQR+YS + YH++M +K+
Sbjct: 475 TSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKE 534
Query: 498 FIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-LPL 556
FIR H++P PL+QR+ EYFQ W+ +GID N +L+ FP+ L+ADI +HL+R +LQ P
Sbjct: 535 FIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPA 594
Query: 557 FGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKG 616
F A +GCLRAL++ KT+ PG+ L+ GD L Y++ GS+E+LRD++V+AILGK
Sbjct: 595 FSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKN 654
Query: 617 DLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAF 676
D+ G + L A P K+SADV+ALTYC L ++ L EVL +YP + +F
Sbjct: 655 DIFGEPV-------SLHAQPG---KSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESF 704
Query: 677 RAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLP------------S 724
+ L ++TFNLR + GL R SQ S + P S
Sbjct: 705 WSKL--EVTFNLRDAA--GGLHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYS 760
Query: 725 ITEAESGAEPGGGP-RPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLS 783
+ S G GP P P P LS + G LL +E+PP + SP P
Sbjct: 761 LLGPGSQNSMGAGPCAPGHPDAAPPLSISDASGLWPELL-QEMPPRHS-PQSPQEDPDCW 818
Query: 784 PALAG 788
P G
Sbjct: 819 PLKLG 823
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 503 bits (1296), Expect = e-142
Identities = 283/700 (40%), Positives = 431/700 (61%), Gaps = 45/700 (6%)
Query: 5 KGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKT 64
+GL+APQNTFL+ I R + T NF+L NAQ +PIVY +DGFC+L+GY R EVMQK+
Sbjct: 8 RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIV-DWPIVYSNDGFCKLSGYHRAEVMQKS 64
Query: 65 CSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVV 124
+C F+YG T + ++++ + E ++ + EI Y+K+ + W + + PI+NE +VV
Sbjct: 65 STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
Query: 125 LFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFG 184
LFL +F DIT P ++S G + A SR VL +L
Sbjct: 125 LFLCTFSDITAFKQP-----------IEDDSCKGWGKFARLTRALTSSRGVLQQLAPSV- 172
Query: 185 RRGQGGMKANN--NVFEPKPSV-PEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVA 241
++G+ K + V + + P+YK + ++LHY V K WD +IL+ TFY A
Sbjct: 173 QKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTA 232
Query: 242 VTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIG 301
+ VPYNV F T + LV D V+++F++DI+LNF TT+V +G+VIS P+ I
Sbjct: 233 ILVPYNVSFK----TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIR 288
Query: 302 LHYLATWFFIDLIAALPFDLLYIFNIT---VTSLVHLLKTVRLLRLLRLLQKLERYSQCS 358
++YL TWF IDL++ LP+D++ F ++SL LK VRLLRL R+ +KL+ Y +
Sbjct: 289 MNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYG 348
Query: 359 AVVLTLLMSVFALLAHWMACIWYVIGRREMEANDP-LLWDIGWLHELGKRLEVPY-VNGS 416
A VL LL+ VF L AHWMACIWY IG E+ D + + WL++L + PY NGS
Sbjct: 349 AAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGS 408
Query: 417 -----VGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVF 471
GGPS+ S YI++LYFT++SLTSVGFGN+ +TD EKIF++ M+IG+L++A +F
Sbjct: 409 GSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIF 468
Query: 472 GNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANEL 531
GNVT I Q+MY+ + YH + ++DF++++++P+ L +R+++Y +TW+++ GID ++
Sbjct: 469 GNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKV 528
Query: 532 LRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDAL 590
L+ P ++RADI +HLNR++ + P F AS GCLRAL++ +T CAPG+ + G+++
Sbjct: 529 LQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESV 588
Query: 591 QAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALT 650
+ +V SGSLEV++D+ V+AILGKGD+ G + + ++ A+V+ALT
Sbjct: 589 DSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEAT----------LAQSCANVRALT 638
Query: 651 YCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQ 690
YC L + L +VL Y + +F L LT+NLR+
Sbjct: 639 YCDLHVIKRDALQKVLEFYTAFSHSFSRNL--ILTYNLRK 676
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 493 bits (1269), Expect = e-139
Identities = 283/727 (38%), Positives = 431/727 (59%), Gaps = 72/727 (9%)
Query: 5 KGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKT 64
+GL+APQNTFL+ I R + T NF+L NAQ +PIVY +DGFC+L+GY R EVMQK+
Sbjct: 8 RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIV-DWPIVYSNDGFCKLSGYHRAEVMQKS 64
Query: 65 CSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVV 124
+C F+YG T + ++++ + E ++ + EI Y+K+ + W + + PI+NE +VV
Sbjct: 65 STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
Query: 125 LFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFG 184
LFL +F DIT P ++S G + A SR VL +L
Sbjct: 125 LFLCTFSDITAFKQP-----------IEDDSCKGWGKFARLTRALTSSRGVLQQLAPSV- 172
Query: 185 RRGQGGMKANN--NVFEPKPSV-PEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVA 241
++G+ K + V + + P+YK + ++LHY V K WD +IL+ TFY A
Sbjct: 173 QKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTA 232
Query: 242 VTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIG 301
+ VPYNV F T + LV D V+++F++DI+LNF TT+V +G+VIS P+ I
Sbjct: 233 ILVPYNVSFK----TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIR 288
Query: 302 LHYLATWFFIDLIAALPFDLLYIFNIT------------------------------VTS 331
++YL TWF IDL++ LP+D++ F ++S
Sbjct: 289 MNYLKTWFVIDLLSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISS 348
Query: 332 LVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEAN 391
L LK VRLLRL R+ +KL+ Y + A VL LL+ VF L AHWMACIWY IG E+
Sbjct: 349 LFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDE 408
Query: 392 DP-LLWDIGWLHELGKRLEVPY-VNGS-----VGGPSRRSAYIAALYFTLSSLTSVGFGN 444
D + + WL++L + PY NGS GGPS+ S YI++LYFT++SLTSVGFGN
Sbjct: 409 DTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGN 468
Query: 445 VCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRL 504
+ +TD EKIF++ M+IG+L++A +FGNVT I Q+MY+ + YH + ++DF++++++
Sbjct: 469 IAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQV 528
Query: 505 PRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRG 563
P+ L +R+++Y +TW+++ GID ++L+ P ++RADI +HLNR++ + P F AS G
Sbjct: 529 PKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDG 588
Query: 564 CLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADI 623
CLRAL++ +T CAPG+ + G+++ + +V SGSLEV++D+ V+AILGKGD+ G
Sbjct: 589 CLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVF 648
Query: 624 PEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRD 683
+ + ++ A+V+ALTYC L + L +VL Y + +F L
Sbjct: 649 WKEAT----------LAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNL--I 696
Query: 684 LTFNLRQ 690
LT+NLR+
Sbjct: 697 LTYNLRK 703
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 491 bits (1265), Expect = e-138
Identities = 274/704 (38%), Positives = 428/704 (60%), Gaps = 55/704 (7%)
Query: 5 KGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKT 64
+GL+APQNTFL+ I R + S+FLL NAQ +P+VY +DGFC+L+GY R +VMQK+
Sbjct: 6 RGLVAPQNTFLENIVRR--SSESSFLLGNAQIV-DWPVVYSNDGFCKLSGYHRADVMQKS 62
Query: 65 CSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVV 124
+C F+YG T + ++++ + + ++ + E+ Y+K+ + W + + PI+NE +VV
Sbjct: 63 STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
Query: 125 LFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTG--- 181
LFL +FKDIT P + +G + + A SR+VL +LT
Sbjct: 123 LFLCTFKDITLFKQP-IEDDSTKGWTKFA----------RLTRALTNSRSVLQQLTPMNK 171
Query: 182 ----HFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLAT 237
H R ++ +++ +P+YK + ++LHY K WD +IL+ T
Sbjct: 172 TEVVHKHSRLAEVLQLGSDI------LPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 225
Query: 238 FYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAP 297
FY A+ VPYNV F T + LV D V+++F++DI+LNF TT+V G+VIS P
Sbjct: 226 FYTAIMVPYNVSFK----TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDP 281
Query: 298 RSIGLHYLATWFFIDLIAALPFDLLYIFNIT---VTSLVHLLKTVRLLRLLRLLQKLERY 354
+ I ++YL TWF IDL++ LP+D++ F ++SL LK VRLLRL R+ +KL+ Y
Sbjct: 282 KLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHY 341
Query: 355 SQCSAVVLTLLMSVFALLAHWMACIWYVIGRREM--EANDPLLWDIGWLHELGKRLEVPY 412
+ A VL LL+ VF L+AHW+ACIWY IG E+ E + + D WL++L + PY
Sbjct: 342 LEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQID-SWLYQLALSIGTPY 400
Query: 413 -VNGSVG----GPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMH 467
N S G GPS+ S Y+++LYFT++SLT++GFGN+ TD EK+FS+ M++G+L++
Sbjct: 401 RYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLY 460
Query: 468 AVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGID 527
A +FGNVT I Q+MY+ + YH + +++DF++++++P+ L +R+++Y +TW+++ GID
Sbjct: 461 ATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGID 520
Query: 528 ANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRR 586
++L P ++RADI +HLNR++ + P F AS GCLRAL++ +T CAPG+ +
Sbjct: 521 TEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHA 580
Query: 587 GDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADV 646
G+++ A +V SGSLEV++D+ V+AILGKGD+ G + + A+V
Sbjct: 581 GESVDALCFVVSGSLEVIQDDEVVAILGKGDVFG----------DIFWKETTLAHACANV 630
Query: 647 KALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQ 690
+ALTYC L + L +VL Y + +F L LT NLR+
Sbjct: 631 RALTYCDLHIIKREALLKVLDFYTAFANSFSRNL--TLTCNLRK 672
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 478 bits (1231), Expect = e-135
Identities = 316/800 (39%), Positives = 437/800 (54%), Gaps = 77/800 (9%)
Query: 204 VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF---SGDDDTPITS 260
+PEYK+ + R +LHYS KA+WD LILL Y AV PY+ F ++ P T
Sbjct: 45 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 104
Query: 261 -----RHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIA 315
+ V D+ V+++FI+DI++NFRTTYV+ + +V+S P I +HY WF ID++A
Sbjct: 105 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 164
Query: 316 ALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHW 375
A+PFDLL IF L+ LLKT RLLRL+R+ +KL+RYS+ A VL LLM FAL+AHW
Sbjct: 165 AIPFDLL-IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHW 223
Query: 376 MACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLS 435
+ACIWY IG E D IGWLH LG ++ PY + +GGPS + Y+ ALYFT S
Sbjct: 224 LACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFS 280
Query: 436 SLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDL 495
SLTSVGFGNV NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS + YH++M +
Sbjct: 281 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 340
Query: 496 KDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-L 554
++FIR H++P PL+QR+ EYFQ W+ +GID N +L+ FP+ L+ADI +HLNR +LQ
Sbjct: 341 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 400
Query: 555 PLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILG 614
F A++GCLRAL++ KT+ PG+ L+ GD L A Y++ GS+E+LR ++V+AILG
Sbjct: 401 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 460
Query: 615 KGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGA 674
K D+ G + L A P K++ DV+ALTYC L ++ L EVL +YPE+
Sbjct: 461 KNDIFGEPL-------NLYARPG---KSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSD 510
Query: 675 AFRAGLPRDLTFNLRQ-----GSDTS-----GLSRFSRSPRLSQPRSESLGSSSDKTLPS 724
F + L ++TFNLR GS S G SR R +LS R + + +
Sbjct: 511 HFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSR-QRKRKLSFRRRTDKDTEQPGEVSA 567
Query: 725 ITEAESGAEPGGGPRPRRPL-LLPNLSPARPRGSLVSLLGEELPPFSALVSSP-SLSPSL 782
+ +GA P RP P P+ P+ P S +E P S SSP L P
Sbjct: 568 LGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESS-----EDEGPGRS---SSPLRLVPFS 619
Query: 783 SPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGS-TAEAP 841
SP G+ P G P K P G F G+ + S ++
Sbjct: 620 SPRPPGE----PPGGEPLMEDCEKSSDTCNPLSGAF----------SGVSNIFSFWGDSR 665
Query: 842 SFRFSRRPELPRPRSQ-----APPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQ 896
++ P P P G RP ++ S + ++ ++ RL +S V Q
Sbjct: 666 GRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQ 725
Query: 897 -LSRELRHIMGLLQARLGP-PGHPAGSAWTPDPPCPQLRPPCLS------PCASRPP--P 946
L R++ + A P PG + S P P P L LS C PP P
Sbjct: 726 LLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAP 785
Query: 947 SL-QDTTLAEVHCPASVGTM 965
L Q+ + P +G +
Sbjct: 786 ELPQEGPTRRLSLPGQLGAL 805
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 478 bits (1231), Expect = e-135
Identities = 316/800 (39%), Positives = 437/800 (54%), Gaps = 77/800 (9%)
Query: 204 VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF---SGDDDTPITS 260
+PEYK+ + R +LHYS KA+WD LILL Y AV PY+ F ++ P T
Sbjct: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
Query: 261 -----RHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIA 315
+ V D+ V+++FI+DI++NFRTTYV+ + +V+S P I +HY WF ID++A
Sbjct: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
Query: 316 ALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHW 375
A+PFDLL IF L+ LLKT RLLRL+R+ +KL+RYS+ A VL LLM FAL+AHW
Sbjct: 505 AIPFDLL-IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHW 563
Query: 376 MACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLS 435
+ACIWY IG E D IGWLH LG ++ PY + +GGPS + Y+ ALYFT S
Sbjct: 564 LACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFS 620
Query: 436 SLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDL 495
SLTSVGFGNV NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS + YH++M +
Sbjct: 621 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 680
Query: 496 KDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-L 554
++FIR H++P PL+QR+ EYFQ W+ +GID N +L+ FP+ L+ADI +HLNR +LQ
Sbjct: 681 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 740
Query: 555 PLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILG 614
F A++GCLRAL++ KT+ PG+ L+ GD L A Y++ GS+E+LR ++V+AILG
Sbjct: 741 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
Query: 615 KGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGA 674
K D+ G + L A P K++ DV+ALTYC L ++ L EVL +YPE+
Sbjct: 801 KNDIFGEPL-------NLYARPG---KSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSD 850
Query: 675 AFRAGLPRDLTFNLRQ-----GSDTS-----GLSRFSRSPRLSQPRSESLGSSSDKTLPS 724
F + L ++TFNLR GS S G SR R +LS R + + +
Sbjct: 851 HFWSSL--EITFNLRDTNMIPGSPGSTELEGGFSR-QRKRKLSFRRRTDKDTEQPGEVSA 907
Query: 725 ITEAESGAEPGGGPRPRRPL-LLPNLSPARPRGSLVSLLGEELPPFSALVSSP-SLSPSL 782
+ +GA P RP P P+ P+ P S +E P S SSP L P
Sbjct: 908 LGPGRAGAGPSSRGRPGGPWGESPSSGPSSPESS-----EDEGPGRS---SSPLRLVPFS 959
Query: 783 SPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGS-TAEAP 841
SP G+ P G P K P G F G+ + S ++
Sbjct: 960 SPRPPGE----PPGGEPLMEDCEKSSDTCNPLSGAF----------SGVSNIFSFWGDSR 1005
Query: 842 SFRFSRRPELPRPRSQ-----APPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQ 896
++ P P P G RP ++ S + ++ ++ RL +S V Q
Sbjct: 1006 GRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLSADMATVLQ 1065
Query: 897 -LSRELRHIMGLLQARLGP-PGHPAGSAWTPDPPCPQLRPPCLS------PCASRPP--P 946
L R++ + A P PG + S P P P L LS C PP P
Sbjct: 1066 LLQRQMTLVPPAYSAVTTPGPGPTSTSPLLPVSPLPTLTLDSLSQVSQFMACEELPPGAP 1125
Query: 947 SL-QDTTLAEVHCPASVGTM 965
L Q+ + P +G +
Sbjct: 1126 ELPQEGPTRRLSLPGQLGAL 1145
Score = 154 bits (389), Expect = 4e-37
Identities = 74/155 (47%), Positives = 104/155 (67%), Gaps = 11/155 (7%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
MPV +G +APQNTFLDTI +F+G F++ANA+ ++YC+DGFCEL GY R EV
Sbjct: 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANAR-VENCAVIYCNDGFCELCGYSRAEV 59
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQ+ C+C FL+GP T A ++ +AL G +E + EI FYRKDGS F CL+D++P+KNE
Sbjct: 60 MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
Query: 121 GEVVLFLFSFKDITQS---GSPGLGPQGGRGDSNH 152
G V++F+ +F+ + + GSP D+NH
Sbjct: 120 GAVIMFILNFEVVMEKDMVGSPA-------HDTNH 147
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 469 bits (1207), Expect = e-132
Identities = 338/952 (35%), Positives = 476/952 (50%), Gaps = 153/952 (16%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
MPV +G +APQNT+LDTI +F+G FL+ANAQ I+YC+DGFCEL GY R EV
Sbjct: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQ-MENCAIIYCNDGFCELFGYSRVEV 59
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQ+ C+C FL GP T A+ RL +AL G +E + +I +YRKD S+F CL+D++P+KNE
Sbjct: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
Query: 121 GEVVLFLFSFKDITQ-------------------------SGSPG-LGPQGGRGDSNHEN 154
G V++F+ +F+D+ Q G PG GP GRG +
Sbjct: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
Query: 155 SLGR---RGATWKFRSARRRSRTVLHRLTGH-FGRRGQGGMKANNNVFEPKPSV-PEYKV 209
+ + + R S T + + H R Q + V V PEYK+
Sbjct: 180 QIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKL 239
Query: 210 ASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF--SGDDDT-----PITSRH 262
+ R +LHYS KA+WD LILL Y AV PY+ F S D++ T
Sbjct: 240 QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSP 299
Query: 263 TLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLL 322
V D+ V+++F++DI++NFRTTYV+ + +V+S PR I +HY WF ID++AA+PFDLL
Sbjct: 300 LTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL 359
Query: 323 YIFNI---TVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACI 379
IF T+L+ LLKT RLLRL+R+ +KL+RYS+ A VL LLM FAL+AHW+ACI
Sbjct: 360 -IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI 418
Query: 380 WYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTS 439
L +G+ G+V + + + SL
Sbjct: 419 C-------------SLTSVGF--------------GNVSPNTNSEKVFSICVMLIGSLMY 451
Query: 440 VG-FGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDF 498
FGNV +AIIQR+YS + YH++M +K+F
Sbjct: 452 ASIFGNV-----------------------------SAIIQRLYSGTARYHTQMLRVKEF 482
Query: 499 IRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-LPLF 557
IR H++P PL+QR+ EYFQ W+ +GID N +L+ FP+ L+ADI +HL+R +LQ P F
Sbjct: 483 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAF 542
Query: 558 GAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGD 617
A +GCLRAL++ KT+ PG+ L+ GD L Y++ GS+E+LRD++V+AILGK D
Sbjct: 543 SGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKND 602
Query: 618 LIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFR 677
+ G + L A P K+SADV+ALTYC L ++ L EVL +YP + +F
Sbjct: 603 IFGEPV-------SLHAQPG---KSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFW 652
Query: 678 AGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLG-----SSSDKTLPSITEAESGA 732
+ L ++TFNLR D +G SPR + + G + SD P SG
Sbjct: 653 SKL--EVTFNLR---DAAG--GLHSSPRQAPGSQDHQGFFLSDNQSDAAPPLSISDASGL 705
Query: 733 EP----GGGPR--PRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSP-SLSPSLSPA 785
P PR P+ P P+ P + GS + L ++ + VSS S L
Sbjct: 706 WPELLQEMPPRHSPQSPQEDPDCWPLK-LGSRLEQLQAQMNRLESRVSSDLSRILQLLQK 764
Query: 786 LAGQGHSA-------------SPHGPPRCSAAWKPPQLLIPPLGT--FGP-PDLSPRIVD 829
QGH++ P S + PQ +PP T +G D SP+
Sbjct: 765 PMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSYGDLDDCSPK--- 821
Query: 830 GIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVC 881
S+ P + L Q P G P EV+ +C
Sbjct: 822 ---HRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLIC 870
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 463 bits (1192), Expect = e-130
Identities = 250/627 (39%), Positives = 394/627 (62%), Gaps = 43/627 (6%)
Query: 5 KGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKT 64
+GL+APQNTFL+ I R + S+FLL NAQ +P+VY +DGFC+L+GY R +VMQK+
Sbjct: 6 RGLVAPQNTFLENIVRR--SSESSFLLGNAQIV-DWPVVYSNDGFCKLSGYHRADVMQKS 62
Query: 65 CSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVV 124
+C F+YG T + ++++ + + ++ + E+ Y+K+ + W + + PI+NE +VV
Sbjct: 63 STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
Query: 125 LFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTG--- 181
LFL +FKDIT P + +G + + A SR+VL +LT
Sbjct: 123 LFLCTFKDITLFKQP-IEDDSTKGWTKFA----------RLTRALTNSRSVLQQLTPMNK 171
Query: 182 ----HFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLILLAT 237
H R ++ +++ +P+YK + ++LHY K WD +IL+ T
Sbjct: 172 TEVVHKHSRLAEVLQLGSDI------LPQYKQEAPKTPPHIILHYCAFKTTWDWVILILT 225
Query: 238 FYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAP 297
FY A+ VPYNV F T + LV D V+++F++DI+LNF TT+V G+VIS P
Sbjct: 226 FYTAIMVPYNVSFK----TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDP 281
Query: 298 RSIGLHYLATWFFIDLIAALPFDLLYIFNIT---VTSLVHLLKTVRLLRLLRLLQKLERY 354
+ I ++YL TWF IDL++ LP+D++ F ++SL LK VRLLRL R+ +KL+ Y
Sbjct: 282 KLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHY 341
Query: 355 SQCSAVVLTLLMSVFALLAHWMACIWYVIGRREM--EANDPLLWDIGWLHELGKRLEVPY 412
+ A VL LL+ VF L+AHW+ACIWY IG E+ E + + D WL++L + PY
Sbjct: 342 LEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQID-SWLYQLALSIGTPY 400
Query: 413 -VNGSVG----GPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMH 467
N S G GPS+ S Y+++LYFT++SLT++GFGN+ TD EK+FS+ M++G+L++
Sbjct: 401 RYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLY 460
Query: 468 AVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGID 527
A +FGNVT I Q+MY+ + YH + +++DF++++++P+ L +R+++Y +TW+++ GID
Sbjct: 461 ATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGID 520
Query: 528 ANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRR 586
++L P ++RADI +HLNR++ + P F AS GCLRAL++ +T CAPG+ +
Sbjct: 521 TEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHA 580
Query: 587 GDALQAHYYVCSGSLEVLRDNMVLAIL 613
G+++ A +V SGSLEV++D+ V+AIL
Sbjct: 581 GESVDALCFVVSGSLEVIQDDEVVAIL 607
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 454 bits (1168), Expect = e-127
Identities = 246/508 (48%), Positives = 339/508 (66%), Gaps = 28/508 (5%)
Query: 204 VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHT 263
+PEYK+ + ++ +LHYS KA+WD LILL Y A+ PY+ F +D R
Sbjct: 385 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 444
Query: 264 LVS-------DIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAA 316
S D+ V+++FI+DI++NFRTTYV+Q+ +V+S P I +HY WF ID++AA
Sbjct: 445 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 504
Query: 317 LPFDLLYIFNIT--VTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAH 374
+PFDLL + + T+L+ LLKT RLLRL+R+ +KL+RYS+ A VL LLM +FAL+AH
Sbjct: 505 IPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAH 564
Query: 375 WMACIWYVIGRREMEANDPLLWD-IGWLHELGKRLEVPYVNG-SVGGPSRRSAYIAALYF 432
W+ACIWY IG E P L D IGWL LG+++ Y + S GPS + Y+ ALYF
Sbjct: 565 WLACIWYAIGNVER----PYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYF 620
Query: 433 TLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRM 492
T SSLTSVGFGNV NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS + YH +M
Sbjct: 621 TFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQM 680
Query: 493 KDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL 552
+K+FIR H++P PL+QR+ EYFQ W +GID N +L+ FP+ L+ADI +HLN+ +L
Sbjct: 681 LRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLL 740
Query: 553 Q-LPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLA 611
Q F AS+GCLRAL++ KT+ PG+ L+ GD L A Y++ GS+E+L+D++V+A
Sbjct: 741 QNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVA 800
Query: 612 ILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPE 671
ILGK D+ G ++ +PG K++ADV+ALTYC L ++ L EVL +YPE
Sbjct: 801 ILGKNDIFG-EMVHLYAKPG---------KSNADVRALTYCDLHKIQREDLLEVLDMYPE 850
Query: 672 YGAAFRAGLPRDLTFNLRQGSDTSGLSR 699
+ F L +LTFNLR S + L R
Sbjct: 851 FSDHFLTNL--ELTFNLRHESAKADLLR 876
Score = 139 bits (349), Expect = 2e-32
Identities = 60/136 (44%), Positives = 96/136 (70%), Gaps = 1/136 (0%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
MPV +G +APQNTFL TI +F+G + F++ANA+ + I+YC+DGFCE+TG+ R +V
Sbjct: 1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANAR-VQNCAIIYCNDGFCEMTGFSRPDV 59
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQK C+C FL+GPET + ++ +AL G +E + E+ +Y K+GS F C ++P+KN+
Sbjct: 60 MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
Query: 121 GEVVLFLFSFKDITQS 136
G ++F+ +F+ +T +
Sbjct: 120 GVAMMFIINFEYVTDN 135
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 437 bits (1123), Expect = e-122
Identities = 244/648 (37%), Positives = 387/648 (59%), Gaps = 52/648 (8%)
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQK+ +C F+YG T + ++++ + + ++ + E+ Y+K+ + W + + PI+NE
Sbjct: 1 MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
Query: 121 GEVVLFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLT 180
+VVLFL +FKDIT P + +G + + A SR+VL +LT
Sbjct: 61 EKVVLFLCTFKDITLFKQP-IEDDSTKGWTKFA----------RLTRALTNSRSVLQQLT 109
Query: 181 G-------HFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLHYSVSKAIWDGLI 233
H R ++ +++ +P+YK + ++LHY K WD +I
Sbjct: 110 PMNKTEVVHKHSRLAEVLQLGSDI------LPQYKQEAPKTPPHIILHYCAFKTTWDWVI 163
Query: 234 LLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQV 293
L+ TFY A+ VPYNV F T + LV D V+++F++DI+LNF TT+V G+V
Sbjct: 164 LILTFYTAIMVPYNVSFK----TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEV 219
Query: 294 ISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNIT---VTSLVHLLKTVRLLRLLRLLQK 350
IS P+ I ++YL TWF IDL++ LP+D++ F ++SL LK VRLLRL R+ +K
Sbjct: 220 ISDPKLIRMNYLKTWFVIDLLSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARK 279
Query: 351 LERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREM--EANDPLLWDIGWLHELGKRL 408
L+ Y + A VL LL+ VF L+AHW+ACIWY IG E+ E + + D WL++L +
Sbjct: 280 LDHYLEYGAAVLVLLVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQID-SWLYQLALSI 338
Query: 409 EVPY-VNGSVG----GPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIG 463
PY N S G GPS+ S Y+++LYFT++SLT++GFGN+ TD EK+FS+ M++G
Sbjct: 339 GTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVG 398
Query: 464 ALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVN 523
+L++A +FGNVT I Q+MY+ + YH + +++DF++++++P+ L +R+++Y +TW+++
Sbjct: 399 SLLYATIFGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMS 458
Query: 524 SGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEY 582
GID ++L P ++RADI +HLNR++ + P F AS GCLRAL++ +T CAPG+
Sbjct: 459 KGIDTEKVLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDL 518
Query: 583 LLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKT 642
+ G+++ A +V SGSLEV++D+ V+AILGKGD+ G + +
Sbjct: 519 IYHAGESVDALCFVVSGSLEVIQDDEVVAILGKGDVFG----------DIFWKETTLAHA 568
Query: 643 SADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQ 690
A+V+ALTYC L + L +VL Y + +F L LT NLR+
Sbjct: 569 CANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNL--TLTCNLRK 614
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 422 bits (1085), Expect = e-118
Identities = 217/432 (50%), Positives = 295/432 (68%), Gaps = 13/432 (3%)
Query: 204 VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF---SGDDDTPITS 260
+PEYK+ + R +LHYS KA+WD LILL Y AV PY+ F ++ P T
Sbjct: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
Query: 261 -----RHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIA 315
+ V D+ V+++FI+DI++NFRTTYV+ + +V+S P I +HY WF ID++A
Sbjct: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
Query: 316 ALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHW 375
A+PFDLL IF L+ LLKT RLLRL+R+ +KL+RYS+ A VL LLM FAL+AHW
Sbjct: 505 AIPFDLL-IFGSGSEELIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHW 563
Query: 376 MACIWYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLS 435
+ACIWY IG E D IGWLH LG ++ PY + +GGPS + Y+ ALYFT S
Sbjct: 564 LACIWYAIGNMEQPHMDSR---IGWLHNLGDQIGKPYNSSGLGGPSIKDKYVTALYFTFS 620
Query: 436 SLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDL 495
SLTSVGFGNV NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS + YH++M +
Sbjct: 621 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 680
Query: 496 KDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-L 554
++FIR H++P PL+QR+ EYFQ W+ +GID N +L+ FP+ L+ADI +HLNR +LQ
Sbjct: 681 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 740
Query: 555 PLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILG 614
F A++GCLRAL++ KT+ PG+ L+ GD L A Y++ GS+E+LR ++V+AILG
Sbjct: 741 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
Query: 615 KGDLIGADIPEP 626
G G + P
Sbjct: 801 MGWGAGTGLEMP 812
Score = 154 bits (389), Expect = 4e-37
Identities = 74/155 (47%), Positives = 104/155 (67%), Gaps = 11/155 (7%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
MPV +G +APQNTFLDTI +F+G F++ANA+ ++YC+DGFCEL GY R EV
Sbjct: 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANAR-VENCAVIYCNDGFCELCGYSRAEV 59
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQ+ C+C FL+GP T A ++ +AL G +E + EI FYRKDGS F CL+D++P+KNE
Sbjct: 60 MQRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNED 119
Query: 121 GEVVLFLFSFKDITQS---GSPGLGPQGGRGDSNH 152
G V++F+ +F+ + + GSP D+NH
Sbjct: 120 GAVIMFILNFEVVMEKDMVGSPA-------HDTNH 147
>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
isoform 2 [Homo sapiens]
Length = 732
Score = 330 bits (846), Expect = 4e-90
Identities = 172/337 (51%), Positives = 231/337 (68%), Gaps = 15/337 (4%)
Query: 204 VPEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHT 263
+PEYK+ + ++ +LHYS KA+WD LILL Y A+ PY+ F +D R
Sbjct: 378 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 437
Query: 264 LVS-------DIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAA 316
S D+ V+++FI+DI++NFRTTYV+Q+ +V+S P I +HY WF ID++AA
Sbjct: 438 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 497
Query: 317 LPFDLLYIFNIT--VTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAH 374
+PFDLL + + T+L+ LLKT RLLRL+R+ +KL+RYS+ A VL LLM +FAL+AH
Sbjct: 498 IPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAH 557
Query: 375 WMACIWYVIGRREMEANDPLLWD-IGWLHELGKRLEVPYVNG-SVGGPSRRSAYIAALYF 432
W+ACIWY IG E P L D IGWL LG+++ Y + S GPS + Y+ ALYF
Sbjct: 558 WLACIWYAIGNVER----PYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYF 613
Query: 433 TLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRM 492
T SSLTSVGFGNV NT++EKIFSIC MLIG+LM+A +FGNV+AIIQR+YS + YH +M
Sbjct: 614 TFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQM 673
Query: 493 KDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDAN 529
+K+FIR H++P PL+QR+ EYFQ W +GID N
Sbjct: 674 LRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMN 710
Score = 139 bits (349), Expect = 2e-32
Identities = 60/136 (44%), Positives = 96/136 (70%), Gaps = 1/136 (0%)
Query: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
MPV +G +APQNTFL TI +F+G + F++ANA+ + I+YC+DGFCE+TG+ R +V
Sbjct: 1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANAR-VQNCAIIYCNDGFCEMTGFSRPDV 59
Query: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
MQK C+C FL+GPET + ++ +AL G +E + E+ +Y K+GS F C ++P+KN+
Sbjct: 60 MQKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQE 119
Query: 121 GEVVLFLFSFKDITQS 136
G ++F+ +F+ +T +
Sbjct: 120 GVAMMFIINFEYVTDN 135
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 169 bits (429), Expect = 9e-42
Identities = 193/803 (24%), Positives = 322/803 (40%), Gaps = 126/803 (15%)
Query: 128 FSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFGRRG 187
FS + +PG GP G + RG+ F +R+ +L F R
Sbjct: 125 FSCRGAASGPAPGPGPAEEAGSEEAGPAGEPRGSQASFM--QRQFGALLQPGVNKFSLRM 182
Query: 188 QGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLH-YSVSKAIWDGLILLATFYVAVTVPY 246
G KA E +V S G ++H YS + WD +LL + +P
Sbjct: 183 FGSQKAVEREQE--------RVKSAGA---WIIHPYSDFRFYWDFTMLLFMVGNLIIIPV 231
Query: 247 NVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSG-QVISAPRSIGLHYL 305
+ F D+ T+ +V ++ + F++D++LNFRT V + ++I P I YL
Sbjct: 232 GITFFKDE----TTAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYL 287
Query: 306 ATWFFIDLIAALPFDLLYIFN-----------------ITVTSLVHLLKTVRLLRLLRLL 348
TWF +D ++++P D +++ + T ++ LL+ +RL RL+R +
Sbjct: 288 RTWFVVDFVSSIPVDYIFLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYI 347
Query: 349 QKLER-----YSQCSAVV-LTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIG--- 399
+ E Y SAV+ + L+S+ LL HW C+ +++ P+L D
Sbjct: 348 HQWEEIFHMTYDLASAVMRICNLISMMLLLCHWDGCLQFLV---------PMLQDFPRNC 398
Query: 400 WLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICT 459
W+ +NG V S Y AL+ +S + +G+G + + ++ +
Sbjct: 399 WVS----------INGMVNH-SWSELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLS 447
Query: 460 MLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTT 519
M++GA +A+ G+ TA+IQ + S R Y + K ++ ++ H+LP +Q++ +Y++
Sbjct: 448 MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHR 507
Query: 520 WAVNSGIDANELLRDFPDELRADIA-MHLNREILQLPLFGAASRGCLRALSLHIKTSFCA 578
+ D + +L + LR +I + + + +PLF A + A+ +K
Sbjct: 508 YQ-GKMFDEDSILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQ 566
Query: 579 PGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNF 638
PG+Y++R G + Y++ G + VL L G G
Sbjct: 567 PGDYIIREGTIGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFG----------------EI 610
Query: 639 VLKT----SADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAF---------RAGLPRDLT 685
L T +A V+A TYC L LS EVL YP AF R G +
Sbjct: 611 CLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSIL 670
Query: 686 FNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLL 745
+ Q SG+ + + + D+ + + +AE G G P P P
Sbjct: 671 LHKVQHDLNSGVFNNQENAIIQEI------VKYDREM--VQQAELGQRVGLFPPPPPP-- 720
Query: 746 LPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSL--SPALAGQGHSASPHGPPRCSA 803
P ++ A + +L F V+ P + P SP L + P GP +A
Sbjct: 721 -PQVTSA-----IATLQQAAAMSFCPQVARPLVGPLALGSPRLVRR----PPPGPAPAAA 770
Query: 804 AWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTA---EAPSFRFSRRPELPRPRSQAPP 860
+ PP PP G P SPR G A P+ R RP S + P
Sbjct: 771 SPGPP----PPASPPGAP-ASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPLSASQP 825
Query: 861 TGTRPSPELASEAEEVKEKVCRL 883
+ +P A+ RL
Sbjct: 826 SLPHGAPGPAASTRPASSSTPRL 848
Score = 33.1 bits (74), Expect = 1.4
Identities = 36/122 (29%), Positives = 46/122 (37%), Gaps = 16/122 (13%)
Query: 896 QLSRELRHIMGLLQARL--GPPGHPAGSAWTPDPPCPQLRP--------PCLSPCASRPP 945
Q++R L + L RL PP PA +A +P PP P P P SP P
Sbjct: 741 QVARPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPA 800
Query: 946 -----PSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPP 1000
P+L L+ P S S P S P LGP+P A+ P
Sbjct: 801 APLAGPALPARRLSRASRPLSASQPSLPHGAPGPAASTRPASSSTPR-LGPTPAARAAAP 859
Query: 1001 TP 1002
+P
Sbjct: 860 SP 861
Score = 30.8 bits (68), Expect = 6.8
Identities = 36/121 (29%), Positives = 49/121 (40%), Gaps = 27/121 (22%)
Query: 884 NQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASR 943
N + + + QE+ + RE+ + QA LG + P PP PQ+ +
Sbjct: 684 NNQENAIIQEIVKYDREM-----VQQAELGQ----RVGLFPPPPPPPQVTSAIAT----- 729
Query: 944 PPPSLQDTTLAEVHCPAS----VGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASP 999
LQ A CP VG + G+ L RP PP P+ P P P P ASP
Sbjct: 730 ----LQQAA-AMSFCPQVARPLVGPLALGSPRLVRRP---PPGPA-PAAASPGPPPPASP 780
Query: 1000 P 1000
P
Sbjct: 781 P 781
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 167 bits (422), Expect = 6e-41
Identities = 175/694 (25%), Positives = 287/694 (41%), Gaps = 106/694 (15%)
Query: 169 RRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLH-YSVSKA 227
RR T+L F R G KA + + +V S G ++H YS +
Sbjct: 46 RRHLGTLLQPTVNKFSLRVFGSHKA--------VEIEQERVKSAGA---WIIHPYSDFRF 94
Query: 228 IWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYV 287
WD ++LL + +P + F ++++P +V ++ + F+LD++LNFRT V
Sbjct: 95 YWDLIMLLLMVGNLIVLPVGITFFKEENSP----PWIVFNVLSDTFFLLDLVLNFRTGIV 150
Query: 288 SQSG-QVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFN-------------------I 327
+ G +++ APR+I YL TWF +DLI+++P D +++ +
Sbjct: 151 VEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIV 210
Query: 328 TVTSLVHLLKTVRLLRLLRLLQKLER-----YSQCSAVVLTL-LMSVFALLAHWMACIWY 381
T ++ LL+ +RL RL+R + + E Y SAVV L+ + LL HW C+ +
Sbjct: 211 RFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQF 270
Query: 382 VIGRREMEANDPLLWDIG---WLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLT 438
++ P+L D W+ +N V R Y AL+ +S +
Sbjct: 271 LV---------PMLQDFPPDCWVS----------INHMVNHSWGRQ-YSHALFKAMSHML 310
Query: 439 SVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDF 498
+G+G + ++ +M++GA +A+ G+ TA+IQ + S R Y + K ++ +
Sbjct: 311 CIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 370
Query: 499 IRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLF 557
+ H+LP +QR+ EY++ + D +L + + LR +I R ++ +PLF
Sbjct: 371 MSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIINFTCRGLVAHMPLF 429
Query: 558 GAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGD 617
A + A+ ++ PG+ ++R G + Y++ G L VL L G
Sbjct: 430 AHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGS 489
Query: 618 LIGADIPEPGQEPGLGADPNFVLKT----SADVKALTYCGLQQLSSRGLAEVLRLYPEYG 673
G L T +A V+A TYC L LS VL +P
Sbjct: 490 YFG----------------EICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMR 533
Query: 674 AAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITE------ 727
AF L LR G S L R + S+P S G ++ L
Sbjct: 534 RAFETVAMDRL---LRIGKKNSILQR-----KRSEPSPGSSGGIMEQHLVQHDRDMARGV 585
Query: 728 ----AESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLS 783
+GA+ G P PL+ L A ++ L + P SP+ + S
Sbjct: 586 RGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARS 645
Query: 784 PALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGT 817
A G ASP P R +L PP T
Sbjct: 646 -AWRSAGSPASPLVPVRAGPWASTSRLPAPPART 678
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 165 bits (418), Expect = 2e-40
Identities = 206/893 (23%), Positives = 334/893 (37%), Gaps = 161/893 (18%)
Query: 185 RRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCL-------------LLH-YSVSKAIWD 230
R GQ G +P V ++ + G + + ++H YS + WD
Sbjct: 207 RLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDFRFYWD 266
Query: 231 GLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQS 290
+LL + +P + F D++T +VSD F++D++LNFRT V +
Sbjct: 267 LTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDT----FFLIDLVLNFRTGIVVED 322
Query: 291 G-QVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNIT-----------------VTSL 332
++I P+ I + YL +WF +D I+++P D +++ T T +
Sbjct: 323 NTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVETRIDSEVYKTARALRIVRFTKI 382
Query: 333 VHLLKTVRLLRLLRLLQKLER-----YSQCSAVV-LTLLMSVFALLAHWMACIWYVIGRR 386
+ LL+ +RL RL+R + + E Y SAVV + L+ + LL HW C+ +++
Sbjct: 383 LSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLV--- 439
Query: 387 EMEANDPLLWDIG---WLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFG 443
P+L D W+ +N V S Y AL+ +S + +G+G
Sbjct: 440 ------PMLQDFPDDCWVS----------INNMVNN-SWGKQYSYALFKAMSHMLCIGYG 482
Query: 444 NVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHR 503
++ ++ +M++GA +A+ G+ TA+IQ + S R Y + K ++ ++ H+
Sbjct: 483 RQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHK 542
Query: 504 LPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIA-MHLNREILQLPLFGAASR 562
LP +QR+ +Y++ + D +L + + LR +I + + + +PLF A
Sbjct: 543 LPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADP 601
Query: 563 GCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIGAD 622
+ ++ ++ PG+Y++R G + Y++ G + VL L G G
Sbjct: 602 NFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFG-- 659
Query: 623 IPEPGQEPGLGADPNFVLKT----SADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAF-- 676
L T +A V+A TYC L LS EVL YP AF
Sbjct: 660 --------------EICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFET 705
Query: 677 -------RAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQ--PRSESLGSSSDKTLPSITE 727
R G + + Q SG+ + + + Q + + + +
Sbjct: 706 VALDRLDRIGKKNSILLHKVQHDLNSGVFNYQENEIIQQIVQHDREMAHCAHR-----VQ 760
Query: 728 AESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALA 787
A + A P P PL+ L A S+ L P A + P L A
Sbjct: 761 AAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHH-PRLPAAIFRPPPGSGLGNLGA 819
Query: 788 GQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRFSR 847
GQ PR K Q LIP P SP VD T + SF +
Sbjct: 820 GQ--------TPR---HLKRLQSLIPSALGSASPASSPSQVD-------TPSSSSFHIQQ 861
Query: 848 ----------RPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQL 897
P LP S +PP G SP + + V +
Sbjct: 862 LAGFSAPAGLSPLLP-SSSSSPPPGACGSPSAPTPSAGV-----------------AATT 903
Query: 898 SRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASR-----------PPP 946
H L L P + P PQ P +P +R PPP
Sbjct: 904 IAGFGHFHKALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPPGARGGLGLPEHFLPPPP 963
Query: 947 SLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASP 999
S + + + G + G A L PP EP L ASP
Sbjct: 964 SSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQPEPPSLVAGASGGASP 1016
Score = 41.2 bits (95), Expect = 0.005
Identities = 72/274 (26%), Positives = 95/274 (34%), Gaps = 67/274 (24%)
Query: 715 GSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARP--RGSLVSLLGEELPPFSAL 772
GS S P +T + GA P+ +P SPA P RG L L LPP
Sbjct: 916 GSLSSSDSPLLTPLQPGAR---SPQAAQP------SPAPPGARGGL-GLPEHFLPP---- 961
Query: 773 VSSPSLSPSLSPALAGQ-----------GHSASPHGPPRCSAAWKPPQLLIPPLGTFGPP 821
S SPS SP GQ G ++P PPR +PP L+ G P
Sbjct: 962 -PPSSRSPSSSPGQLGQPPGELSLGLATGPLSTPETPPRQP---EPPSLVAGASGGASPV 1017
Query: 822 DLSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQA--PPTGTRPSPELASEAEEVKEK 879
+PR G+ G + P S P PP + P P++
Sbjct: 1018 GFTPR--GGLSPPGHSPGPPRTFPSAPPRASGSHGSLLLPPASSPPPPQVPQRRGTPPLT 1075
Query: 880 VCRLNQEISRLN-------QEVSQ-LSRELRHIMGLLQAR-------------------L 912
RL Q++ ++ Q+ +Q L R H G A L
Sbjct: 1076 PGRLTQDLKLISASQPALPQDGAQTLRRASPHSSGESMAAFPLFPRAGGGSGGSGSSGGL 1135
Query: 913 GPPGHPAGSAWTPDPPCPQLRPPCLSPCASRPPP 946
GPPG P G+ P + P + S PPP
Sbjct: 1136 GPPGRPYGAI-----PGQHVTLPRKTSSGSLPPP 1164
Score = 31.2 bits (69), Expect = 5.2
Identities = 61/232 (26%), Positives = 78/232 (33%), Gaps = 53/232 (22%)
Query: 688 LRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLP 747
L G T LS PR +P S G+S + T + PG P P P P
Sbjct: 982 LSLGLATGPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGP--PRTFP 1039
Query: 748 NLSPARPRGSLVSLLGEELPPFSA--------LVSSPSLSP-----------SLSPALAG 788
+ +P R GS SLL LPP S+ +P L+P + PAL
Sbjct: 1040 S-APPRASGSHGSLL---LPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQ 1095
Query: 789 QG----HSASPHGPPRCSAAWKPPQLLIP----------PLGTFGPPDLSPRIVDG---- 830
G ASPH AA+ L P G GPP + G
Sbjct: 1096 DGAQTLRRASPHSSGESMAAFP----LFPRAGGGSGGSGSSGGLGPPGRPYGAIPGQHVT 1151
Query: 831 --IEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKV 880
+ S + P F R S PP P E + E V+ K+
Sbjct: 1152 LPRKTSSGSLPPPLSLFGAR----ATSSGGPPLTAGPQREPGARPEPVRSKL 1199
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 163 bits (412), Expect = 9e-40
Identities = 193/823 (23%), Positives = 335/823 (40%), Gaps = 145/823 (17%)
Query: 137 GSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFGRRGQGGMKANNN 196
G G G GG G+ G ++ +R+ ++L F R G KA
Sbjct: 63 GGGGGGGGGGGGEEPAGGFEDAEGPRRQYGFMQRQFTSMLQPGVNKFSLRMFGSQKAVEK 122
Query: 197 VFEPKPSVPEYKVASVGGSRCLLLH-YSVSKAIWDGLILLATFYVAVTVPYNVCFSGDDD 255
E +V + G ++H YS + WD ++L+ V +P + F
Sbjct: 123 EQE--------RVKTAG---FWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFF---- 167
Query: 256 TPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQ-SGQVISAPRSIGLHYLATWFFIDLI 314
T T+ ++ ++A + +F+LD+I+NFRT V++ S ++I P+ I ++YL +WF +D I
Sbjct: 168 TEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFI 227
Query: 315 AALPFDLLYIFN-----------------ITVTSLVHLLKTVRLLRLLRLLQKLER---- 353
+++P D +++ + T ++ LL+ +RL RL+R + + E
Sbjct: 228 SSIPVDYIFLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHM 287
Query: 354 -YSQCSAVVLTL-LMSVFALLAHWMACIWYVIGRREMEANDPLLWDIG---W--LHELGK 406
Y SAVV L+ + LL HW C+ +++ PLL D W L+E+
Sbjct: 288 TYDLASAVVRIFNLIGMMLLLCHWDGCLQFLV---------PLLQDFPPDCWVSLNEM-- 336
Query: 407 RLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALM 466
VN S G Y AL+ +S + +G+G + ++ ++ +M++GA
Sbjct: 337 ------VNDSWG-----KQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATC 385
Query: 467 HAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGI 526
+A+ G+ TA+IQ + S R Y + K ++ ++ H+LP ++Q++ +Y++ +
Sbjct: 386 YAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GKIF 444
Query: 527 DANELLRDFPDELRADIA-MHLNREILQLPLFGAASRGCLRALSLHIKTSFCAPGEYLLR 585
D +L + D LR +I + + + +PLF A + A+ ++ PG+Y++R
Sbjct: 445 DEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIR 504
Query: 586 RGDALQAHYYVCSGSLEVLRDNMVLAILGKGDLIG-ADIPEPGQEPGLGADPNFVLKTSA 644
G + Y++ G V+ + L G G + G + +A
Sbjct: 505 EGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKG-------------RRTA 551
Query: 645 DVKALTYCGLQQLSSRGLAEVLRLYPEYGAAF---------RAG---------LPRDLTF 686
V+A TYC L LS EVL YP AF R G +DL
Sbjct: 552 SVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNT 611
Query: 687 NLRQGSDTSGLSRFSRSPR--------LSQPRSESLGSSSDKTLP-SITEAESGAEPGGG 737
+ + L + + R ++ P+ +L S+S T P S +S
Sbjct: 612 GVFNNQENEILKQIVKHDREMVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQSPPVYTAT 671
Query: 738 PRPRRPLLLPNLSPARPRGSLVSLLGEELPP--FSALVSSPSLSPSLSPALAGQGHSASP 795
L P+ S P+ S + L P ++ V SP P SP A H ASP
Sbjct: 672 SLSHSNLHSPSPSTQTPQPSAI------LSPCSYTTAVCSP---PVQSPLAARTFHYASP 722
Query: 796 HG------------------PPRCSAAWKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGST 837
PP+ PQ P G+ P + + + ++ T
Sbjct: 723 TASQLSLMQQQPQQQVQQSQPPQTQPQQPSPQPQTP--GSSTPKNEVHKSTQALHNTNLT 780
Query: 838 AEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKV 880
E S +P LP + +RP P + + + V
Sbjct: 781 REVRPLSAS-QPSLPH---EVSTLISRPHPTVGESLASIPQPV 819
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 153 bits (386), Expect = 9e-37
Identities = 127/499 (25%), Positives = 238/499 (47%), Gaps = 39/499 (7%)
Query: 229 WDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVS 288
W I L FY + CF D+ LV D + ++L++LD+++ RT ++
Sbjct: 153 WLTAIALPVFYNWYLLICRACF--DELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLE 210
Query: 289 QSGQVISAPRSIGLHY-LATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRL 347
Q G ++S + HY T F +D+++ +P DL Y+ T V + ++ RL
Sbjct: 211 Q-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEF 269
Query: 348 LQKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGK 406
+ E R + + + L+ ++ HW ACI++ I + D W+
Sbjct: 270 FDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTD------SWV----- 318
Query: 407 RLEVPYVNGSVGGPSRRSA-YIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGAL 465
Y N S+ R S YI +LY++ +LT++G D E +F + L+G L
Sbjct: 319 -----YPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVL 372
Query: 466 MHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSG 525
+ A + GNV ++I M + R+ + +++ +K +++ ++ + L+ R++ +F WA
Sbjct: 373 IFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKT 432
Query: 526 IDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLL 584
+D E+L+ PD+L+A+IA++++ + L ++ +F G L L L ++ + +PG+Y+
Sbjct: 433 VDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYIC 492
Query: 585 RRGDALQAHYYVCSGSLEVLRDNMV--LAILGKGDLIG--ADIPEPGQEPGLGADPNFVL 640
++GD + Y + G L V+ D+ V +L G G + + G + G
Sbjct: 493 KKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSG--------N 544
Query: 641 KTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRF 700
+ +A+++++ Y L LS L E L YPE A +A + ++ L+R
Sbjct: 545 RRTANIRSIGYSDLFCLSKDDLMEALTEYPE---AKKALEEKGRQILMKDNLIDEELARA 601
Query: 701 SRSPRLSQPRSESLGSSSD 719
P+ + + E LGSS D
Sbjct: 602 GADPKDLEEKVEQLGSSLD 620
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 153 bits (386), Expect = 9e-37
Identities = 127/499 (25%), Positives = 238/499 (47%), Gaps = 39/499 (7%)
Query: 229 WDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVS 288
W I L FY + CF D+ LV D + ++L++LD+++ RT ++
Sbjct: 171 WLTAIALPVFYNWYLLICRACF--DELQSEYLMLWLVLDYSADVLYVLDVLVRARTGFLE 228
Query: 289 QSGQVISAPRSIGLHY-LATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRL 347
Q G ++S + HY T F +D+++ +P DL Y+ T V + ++ RL
Sbjct: 229 Q-GLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYLKVGTNYPEVRFNRLLKFSRLFEF 287
Query: 348 LQKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGK 406
+ E R + + + L+ ++ HW ACI++ I + D W+
Sbjct: 288 FDRTETRTNYPNMFRIGNLVLYILIIIHWNACIYFAISKFIGFGTD------SWV----- 336
Query: 407 RLEVPYVNGSVGGPSRRSA-YIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGAL 465
Y N S+ R S YI +LY++ +LT++G D E +F + L+G L
Sbjct: 337 -----YPNISIPEHGRLSRKYIYSLYWSTLTLTTIGETPPPVK-DEEYLFVVVDFLVGVL 390
Query: 466 MHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSG 525
+ A + GNV ++I M + R+ + +++ +K +++ ++ + L+ R++ +F WA
Sbjct: 391 IFATIVGNVGSMISNMNASRAEFQAKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKT 450
Query: 526 IDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLL 584
+D E+L+ PD+L+A+IA++++ + L ++ +F G L L L ++ + +PG+Y+
Sbjct: 451 VDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYIC 510
Query: 585 RRGDALQAHYYVCSGSLEVLRDNMV--LAILGKGDLIG--ADIPEPGQEPGLGADPNFVL 640
++GD + Y + G L V+ D+ V +L G G + + G + G
Sbjct: 511 KKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKSG--------N 562
Query: 641 KTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRF 700
+ +A+++++ Y L LS L E L YPE A +A + ++ L+R
Sbjct: 563 RRTANIRSIGYSDLFCLSKDDLMEALTEYPE---AKKALEEKGRQILMKDNLIDEELARA 619
Query: 701 SRSPRLSQPRSESLGSSSD 719
P+ + + E LGSS D
Sbjct: 620 GADPKDLEEKVEQLGSSLD 638
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 146 bits (369), Expect = 8e-35
Identities = 111/449 (24%), Positives = 215/449 (47%), Gaps = 32/449 (7%)
Query: 229 WDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVS 288
W I L Y V CF D+ + L+ D ++++++D+ + RT Y+
Sbjct: 237 WLFCITLPVMYNWTMVIARACF--DELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLE 294
Query: 289 QSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLL 348
Q V + I + F +D+++ +P DLLY + L + +R R+
Sbjct: 295 QGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFF 354
Query: 349 QKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKR 407
Q+ E R + + ++ L+ ++ HW AC++Y I + ND W++
Sbjct: 355 QRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDT------WVY----- 403
Query: 408 LEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMH 467
P +N G R Y+ +LY++ +LT++G D+E +F + LIG L+
Sbjct: 404 ---PDINDPEFGRLARK-YVYSLYWSTLTLTTIGETPPPVR-DSEYVFVVVDFLIGVLIF 458
Query: 468 AVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGID 527
A + GN+ ++I M + R+ + +R+ +K ++ + + +++R++++F W +D
Sbjct: 459 ATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD 518
Query: 528 ANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRR 586
E+L+ PD+LRA+IA++++ + L ++ +F G L L L ++ +PG+Y+ ++
Sbjct: 519 EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKK 578
Query: 587 GDALQAHYYVCSGSLEVLRDNMV--LAILGKGDLIG--ADIPEPGQEPGLGADPNFVLKT 642
GD + Y + G L V+ D+ V +L G G + + G + G +
Sbjct: 579 GDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAG--------NRR 630
Query: 643 SADVKALTYCGLQQLSSRGLAEVLRLYPE 671
+A++K++ Y L LS L E L YP+
Sbjct: 631 TANIKSIGYSDLFCLSKDDLMEALTEYPD 659
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 146 bits (369), Expect = 8e-35
Identities = 111/449 (24%), Positives = 215/449 (47%), Gaps = 32/449 (7%)
Query: 229 WDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVS 288
W I L Y V CF D+ + L+ D ++++++D+ + RT Y+
Sbjct: 168 WLFCITLPVMYNWTMVIARACF--DELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLE 225
Query: 289 QSGQVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLRLL 348
Q V + I + F +D+++ +P DLLY + L + +R R+
Sbjct: 226 QGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPEIRLNRLLRFSRMFEFF 285
Query: 349 QKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWLHELGKR 407
Q+ E R + + ++ L+ ++ HW AC++Y I + ND W++
Sbjct: 286 QRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDT------WVY----- 334
Query: 408 LEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMH 467
P +N G R Y+ +LY++ +LT++G D+E +F + LIG L+
Sbjct: 335 ---PDINDPEFGRLARK-YVYSLYWSTLTLTTIGETPPPVR-DSEYVFVVVDFLIGVLIF 389
Query: 468 AVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGID 527
A + GN+ ++I M + R+ + +R+ +K ++ + + +++R++++F W +D
Sbjct: 390 ATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLWTNKKTVD 449
Query: 528 ANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRR 586
E+L+ PD+LRA+IA++++ + L ++ +F G L L L ++ +PG+Y+ ++
Sbjct: 450 EKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSPGDYICKK 509
Query: 587 GDALQAHYYVCSGSLEVLRDNMV--LAILGKGDLIG--ADIPEPGQEPGLGADPNFVLKT 642
GD + Y + G L V+ D+ V +L G G + + G + G +
Sbjct: 510 GDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAG--------NRR 561
Query: 643 SADVKALTYCGLQQLSSRGLAEVLRLYPE 671
+A++K++ Y L LS L E L YP+
Sbjct: 562 TANIKSIGYSDLFCLSKDDLMEALTEYPD 590
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 132 bits (331), Expect = 2e-30
Identities = 107/416 (25%), Positives = 202/416 (48%), Gaps = 34/416 (8%)
Query: 264 LVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATW-FFIDLIAALPFDLL 322
LV D ++L++LD+++ F T ++ Q V+ R I Y+ TW FF+DL + +P D++
Sbjct: 70 LVLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVV 128
Query: 323 YIFNITVTSLVHLLKTVRLLRLLRLLQKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWY 381
Y+ T + L + +R RL + E R + +A + LM ++ HW +C+++
Sbjct: 129 YVRLGPHTPTLRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNSCLYF 188
Query: 382 VIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSR-RSAYIAALYFTLSSLTSV 440
+ R D W+ Y + + G R R Y+ + YF+ LT+V
Sbjct: 189 ALSRYLGFGRD------AWV----------YPDPAQPGFERLRRQYLYSFYFSTLILTTV 232
Query: 441 GFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIR 500
G A + E +F + L+ + A + G+++++I M + + ++ +K +++
Sbjct: 233 GDTPPPAR-EEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMK 291
Query: 501 VHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGA 559
+ + R L++R+++++Q + +L+ P+ LRA++A+ ++ L ++ +F
Sbjct: 292 LQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQN 351
Query: 560 ASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMV--LAILGKGD 617
L L L ++ +PGEY+ R+GD Q Y + G L V+ D+ + A+LG G
Sbjct: 352 CEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGL 411
Query: 618 LIG--ADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPE 671
G + I G G + +A++K+L Y L LS L EVL YP+
Sbjct: 412 YFGEISIINIKGNMSG--------NRRTANIKSLGYSDLFCLSKEDLREVLSEYPQ 459
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 130 bits (326), Expect = 8e-30
Identities = 102/415 (24%), Positives = 202/415 (48%), Gaps = 32/415 (7%)
Query: 264 LVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFF-IDLIAALPFDLL 322
LV D ++++I D+ + RT ++ Q G ++ + + +Y+ T F +D+ + +P DL+
Sbjct: 176 LVLDYVSDVVYIADLFIRLRTGFLEQ-GLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLI 234
Query: 323 YIFNITVTSLVHLLKTVRLLRLLRLLQKLE-RYSQCSAVVLTLLMSVFALLAHWMACIWY 381
Y + V + + R+ + E R + + ++ L+ ++ HW ACI+Y
Sbjct: 235 YFAVDIHSPEVRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILVIIHWNACIYY 294
Query: 382 VIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVG 441
I + D W++ P + G R YI LY++ +LT++G
Sbjct: 295 AISKSIGFGVDT------WVY--------PNITDPEYGYLARE-YIYCLYWSTLTLTTIG 339
Query: 442 FGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRV 501
D E +F I LIG L+ A + GNV ++I M + R+ + +++ +K +++
Sbjct: 340 ETPPPVK-DEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQF 398
Query: 502 HRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAA 560
++ + ++ +++ +F W +D E+L++ P +LRA+IA++++ L ++ +F
Sbjct: 399 RKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDC 458
Query: 561 SRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMV--LAILGKGDL 618
G L L L ++ +PG+Y+ R+GD + Y + G L V+ D+ V A+L G
Sbjct: 459 EAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSC 518
Query: 619 IG--ADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPE 671
G + + G + G + +A++++L Y L LS L E + YP+
Sbjct: 519 FGEISILNIKGSKMG--------NRRTANIRSLGYSDLFCLSKDDLMEAVTEYPD 565
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 112 bits (279), Expect = 2e-24
Identities = 143/647 (22%), Positives = 263/647 (40%), Gaps = 85/647 (13%)
Query: 228 IWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYV 287
+W +++A + +P F TP H L+ D ++++ LDI +
Sbjct: 658 LWLFFVVMAWNWNCWLIPVRWAFPYQ--TPDNIHHWLLMDYLCDLIYFLDITVFQTRLQF 715
Query: 288 SQSGQVISAPRSIGLHYLATWFF-IDLIAALPFDLLYIFNITVTSLVHLLKTVRLLRLLR 346
+ G +I+ + + +YL + F +DL++ LP D LY+ + V L+ L + ++ +
Sbjct: 716 VRGGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYL-KVGVNPLLRLPRCLKYMAFFE 774
Query: 347 LLQKLERYSQCSAVVLTLLMSVFALLA-HWMACIWYVIGRREMEANDPLLWDIGWLHELG 405
+LE + V + + + L + H +C++Y + +G H
Sbjct: 775 FNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQ---------GLGSTH--- 822
Query: 406 KRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGAL 465
+V VG ++YI YF + +L ++G G T E +F + G
Sbjct: 823 ------WVYDGVG-----NSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLNYFTGVF 870
Query: 466 MHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSG 525
+V+ G + ++ + ++ Y S M ++ +++P+ ++ R+ +++ TW
Sbjct: 871 AFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYTWHSQGM 930
Query: 526 IDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLL 584
+D +EL+ PD++R D+A+ +N I+ ++ LF R + + +++ P +Y+
Sbjct: 931 LDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYLPNDYVC 990
Query: 585 RRGDALQAHYYVCSGSLEVL---RDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLK 641
++G+ + Y + +G ++VL VL L G + G E L A +
Sbjct: 991 KKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFG--------EISLLAVGGGNRR 1042
Query: 642 TSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQGSDTSGLSRFS 701
T A+V A + L L + L E+L YPE R R L N + + S L
Sbjct: 1043 T-ANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKARRMLRSNNKPKEEKSVL---I 1098
Query: 702 RSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSL 761
PR P+ L + A +G G G +G ++
Sbjct: 1099 LPPRAGTPK-----------LFNAALAMTGKMGGKG----------------AKGGKLAH 1131
Query: 762 LGEELPPFSALVSSPSLSPSLSPA-----LAGQGHSASP--HGPPRCSAAWKPPQLLIPP 814
L L +AL ++ + A + G+ SA+P H P+ AA PP PP
Sbjct: 1132 LRARLKELAALEAAAKQQELVEQAKSSQDVKGEEGSAAPDQHTHPK-EAATDPPAPRTPP 1190
Query: 815 LGTFGPPDLSPRI----VDGIEDSGSTAEAPSFRFSRRPELPRPRSQ 857
PP P +G E+ + E S R P P P Q
Sbjct: 1191 EPPGSPPSSPPPASLGRPEGEEEGPAEPEEHSVRICMSPG-PEPGEQ 1236
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 87.4 bits (215), Expect = 6e-17
Identities = 90/454 (19%), Positives = 192/454 (42%), Gaps = 47/454 (10%)
Query: 230 DGLILLATFYVAVTVPYNVCFSG-----DDDTPITSRHTLVSDIAVEMLFILDIILNFRT 284
D L LL V + +N CF T + L++DI +++++ D++
Sbjct: 215 DRLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPR 274
Query: 285 TYVSQSGQVISAPRSIGLHY-LATWFFIDLIAALPFDLLYIFN--ITVTSLVHLLKTVRL 341
+ G +I + HY +T F +D+ + +PFD+ Y+F + +LK
Sbjct: 275 LQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLKYTSF 334
Query: 342 LRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACIWYVIGRREMEANDPLLWDIGWL 401
L+ + + V+ T +F L H AC++Y +N + W+
Sbjct: 335 FEFNHHLESIMDKAYIYRVIRTTGYLLFIL--HINACVYY------WASNYEGIGTTRWV 386
Query: 402 HELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTML 461
++ + Y+ Y+ + +L ++G G T E +F +
Sbjct: 387 YD-----------------GEGNEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLLNFF 428
Query: 462 IGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWA 521
G + + + G + +I + ++ + + M D ++ + +P+ +++R+ +++ TW
Sbjct: 429 SGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEYTWD 488
Query: 522 VNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPG 580
+D ++LL+ P ++ +A+ +N I+ ++ LF + + L +K+ PG
Sbjct: 489 SQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLYLPG 548
Query: 581 EYLLRRGDALQAHYYVCSGSLEVL---RDNMVLAILGKGDLIGADIPEPGQEPGLGADPN 637
+++ ++G+ + Y + G ++VL VL L G + G E G +
Sbjct: 549 DFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFG----EISLLAAGGGN-- 602
Query: 638 FVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPE 671
+ +A+V A + L L + L E+L YP+
Sbjct: 603 ---RRTANVVAHGFANLLTLDKKTLQEILVHYPD 633
>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapiens]
Length = 816
Score = 60.1 bits (144), Expect = 1e-08
Identities = 85/296 (28%), Positives = 107/296 (36%), Gaps = 44/296 (14%)
Query: 706 LSQPRSESLGSSSDKTLPSITEAESGAEPGGGPR-PRRPLLLPNLSPARPRGSLVSLLGE 764
L +P S SL SS+ P + A SG G PR P P S +P+G +
Sbjct: 225 LQRPASRSLSSSAT---PLSSPARSGPSARGTPRAPAHP------SQPKPKGLQALRPPQ 275
Query: 765 ELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFGPPDLS 824
PP ++P+L P S LA + SP PP SA PP L P PP +
Sbjct: 276 VTPPRKD--AAPALGPLSSSPLA----TPSPSAPPSPSA---PPSLQTLPSPPATPPSQA 326
Query: 825 PRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLN 884
+ + + PS S L P QAPP P + +
Sbjct: 327 TTSLGSPTLQATHSFLPSPPLS---PLATPPPQAPPALALPPLQAPPSPPA--------S 375
Query: 885 QEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCASRP 944
+S L Q L + LLQA PP P A P P + P P S+
Sbjct: 376 PPLSPLATPSPQAPNALA--VHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPP--SQA 431
Query: 945 PPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPDPLGPSPVPEASPP 1000
PPSL L P + M PS PP P P PL P+ A PP
Sbjct: 432 PPSLAAPPLQVPPSPPASPPMS---------PSATPP-PQAPPPLAAPPLQLAKPP 477
Score = 48.1 bits (113), Expect = 4e-05
Identities = 82/303 (27%), Positives = 105/303 (34%), Gaps = 26/303 (8%)
Query: 700 FSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLV 759
F SP LS + + LP + S P P P PL P SP P V
Sbjct: 341 FLPSPPLSPLATPPPQAPPALALPPLQAPPS---PPASP-PLSPLATP--SPQAPNALAV 394
Query: 760 SLLGEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFG 819
LL PFS S P +P PA SA+P P + + P L +PP
Sbjct: 395 HLLQA---PFSPPPSPPVQAPFSPPASPPVSPSATP--PSQAPPSLAAPPLQVPPSPPAS 449
Query: 820 PPDLSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEK 879
PP +SP + A AP + ++ P P PP PSP + +
Sbjct: 450 PP-MSPSATPPPQAPPPLA-APPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSP 507
Query: 880 VCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSA----WTPDPPCPQLRPP 935
L +S L Q L LLQ PP P A TP P P
Sbjct: 508 SASL--PMSPLATPPPQAPPVL--AAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR 563
Query: 936 CLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPD-PLGPSPV 994
A PPP + + + P G + T+ P L Y S P+ SP
Sbjct: 564 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATS----TPEELRGYDSGPEGGAAASPP 619
Query: 995 PEA 997
P+A
Sbjct: 620 PDA 622
Score = 44.7 bits (104), Expect = 5e-04
Identities = 97/383 (25%), Positives = 120/383 (31%), Gaps = 85/383 (22%)
Query: 701 SRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLL--------------L 746
+R+P L PR S + P +T A G R+PL
Sbjct: 19 ARAPGLLTPRPPG----SPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESA 74
Query: 747 PNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPP--RCSAA 804
P P R S GE PP + S P SP A P G R SA
Sbjct: 75 PRAGPTRTSRPPASGRGERAPP----AKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAE 130
Query: 805 WKPPQLLIPPLGTFGPPDLSPRIVDGIEDSGSTAEAPSFRFSRRPE-------LPRPRSQ 857
+ + T P + + SG T PS +RR LPRP
Sbjct: 131 ----ETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPS 186
Query: 858 A---PPT-GTRPSPELASEAEEVKEKVCR---------LNQEISR-LNQEVSQLSRELRH 903
A PPT G R S ASE + L + SR L+ + LS R
Sbjct: 187 ARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARS 246
Query: 904 ---------------------IMGLLQARLGPPGHPAGSAWTPDPPCPQLRPPCLSPCAS 942
+ L ++ PP A A P P P +P +
Sbjct: 247 GPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAPPSP 306
Query: 943 RPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEP--------------DP 988
PPSLQ T + P S T G+ L S LP P P P
Sbjct: 307 SAPPSLQ-TLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALALPP 365
Query: 989 LGPSPVPEASPPTPSLLRHSFQS 1011
L P P ASPP L S Q+
Sbjct: 366 LQAPPSPPASPPLSPLATPSPQA 388
>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
Length = 855
Score = 58.9 bits (141), Expect = 2e-08
Identities = 88/317 (27%), Positives = 107/317 (33%), Gaps = 56/317 (17%)
Query: 706 LSQPRSESLGSSSDKTLPSITEAESGAEPGGGPR----PRRP-------LLLPNLSPARP 754
L +P S SL SS+ P + A SG G PR P +P L P ++P R
Sbjct: 234 LQRPASRSLSSSAT---PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRK 290
Query: 755 RGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWK-------- 806
+ P L SSP +PS S AL Q P P S +
Sbjct: 291 ---------DAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLA 341
Query: 807 PPQLLIPP-LGTFGPPDLSPRIVDGIEDSGSTAEAPSFRFSRRPELP--RPRSQAPPTGT 863
PP PP L T P +P T +A P P P QAPP
Sbjct: 342 PPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPPPQAPPALA 401
Query: 864 RPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAW 923
P + + +S L Q L + LLQA PP P A
Sbjct: 402 LPPLQAPPSPPA--------SPPLSPLATPSPQAPNALA--VHLLQAPFSPPPSPPVQAP 451
Query: 924 TPDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYP 983
P P + P P S+ PPSL L P + M PS PP P
Sbjct: 452 FSPPASPPVSPSATPP--SQAPPSLAAPPLQVPPSPPASPPMS---------PSATPP-P 499
Query: 984 SEPDPLGPSPVPEASPP 1000
P PL P+ A PP
Sbjct: 500 QAPPPLAAPPLQLAKPP 516
Score = 48.1 bits (113), Expect = 4e-05
Identities = 82/303 (27%), Positives = 105/303 (34%), Gaps = 26/303 (8%)
Query: 700 FSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEPGGGPRPRRPLLLPNLSPARPRGSLV 759
F SP LS + + LP + S P P P PL P SP P V
Sbjct: 380 FLPSPPLSPLATPPPQAPPALALPPLQAPPS---PPASP-PLSPLATP--SPQAPNALAV 433
Query: 760 SLLGEELPPFSALVSSPSLSPSLSPALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGTFG 819
LL PFS S P +P PA SA+P P + + P L +PP
Sbjct: 434 HLLQA---PFSPPPSPPVQAPFSPPASPPVSPSATP--PSQAPPSLAAPPLQVPPSPPAS 488
Query: 820 PPDLSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEK 879
PP +SP + A AP + ++ P P PP PSP + +
Sbjct: 489 PP-MSPSATPPPQAPPPLA-APPLQLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSP 546
Query: 880 VCRLNQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSA----WTPDPPCPQLRPP 935
L +S L Q L LLQ PP P A TP P P
Sbjct: 547 SASL--PMSPLATPPPQAPPVL--AAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPR 602
Query: 936 CLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEPD-PLGPSPV 994
A PPP + + + P G + T+ P L Y S P+ SP
Sbjct: 603 LTLALAPGPPPPPSRSPSSTLSGPDLAGHSSSATS----TPEELRGYDSGPEGGAAASPP 658
Query: 995 PEA 997
P+A
Sbjct: 659 PDA 661
Score = 41.6 bits (96), Expect = 0.004
Identities = 91/350 (26%), Positives = 119/350 (34%), Gaps = 97/350 (27%)
Query: 734 PGGGPRPRRPLL---LPNLSPA-----RPRGSLVSLLGEELPPFSALVSSPSLS------ 779
P G PRP P+ L L A +P +G P SA + P+ S
Sbjct: 29 PPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPRAGPTRSAGTSSR 88
Query: 780 -PSLSPALAGQGHSASP---------HGPPRCSAAWKPPQLLIPPLGTFG---------- 819
P+ P +G+G A P P R S +P PLG G
Sbjct: 89 NPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPG-----PLGQKGLRISAEETVA 143
Query: 820 ------PPDLSPRIVDGIED-SGSTAEAPSFRFSRRPE-------LPRPRSQA---PPT- 861
P S D SG T PS +RR LPRP A PPT
Sbjct: 144 RGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVGLPRPAPSARPRPPTE 203
Query: 862 GTRPSPELASEAEEVKEKVCR---------LNQEISR-LNQEVSQLSRELRHIMGLLQAR 911
G R S ASE + L + SR L+ + LS AR
Sbjct: 204 GPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSATPLSSP---------AR 254
Query: 912 LGPP--GHPAGSAWTPDPPCPQ----LRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTM 965
GP G P A P P P+ LRPP ++P P+L + + + P+ +
Sbjct: 255 SGPSARGTPRAPAH-PSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAAL 313
Query: 966 ETG--------------TALLDLRPSILPPYPSEPDPLGPSPVPEASPPT 1001
++ T L + PP PS P L P P A+PP+
Sbjct: 314 QSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLPSPPATPPS 363
Score = 37.7 bits (86), Expect = 0.055
Identities = 65/274 (23%), Positives = 97/274 (35%), Gaps = 64/274 (23%)
Query: 783 SPALAGQGHSASPH-GPPRCSAAWKPPQLLIPPLGTFGPPDLSPR-IVDGIEDSGSTAEA 840
SPA+A + +A G PR + + +P PP PR V + +T +
Sbjct: 173 SPAMARRSRAAGTEVGLPRPAPSARPR-----------PPTEGPRKSVSSASEHSTTEPS 221
Query: 841 PSFRFSRRPE----LPRPRSQAPPTGTRP-------------SPELASEAEEVKEKVCRL 883
P+ R RRP L RP S++ + P +P + + K K +
Sbjct: 222 PAAR--RRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQA 279
Query: 884 NQEISRLNQEVSQLSRELRHIMGLLQARLGPPGHPAGSAWTPDPP------------CPQ 931
+ +V+ ++ +G L + P+ + + PP C
Sbjct: 280 LRP-----PQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQL 334
Query: 932 LRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALLDLRPSILPPYPSEP----- 986
P L+P + PPSLQ T + P S T G+ L S LP P P
Sbjct: 335 ATPLPLAPPSPSAPPSLQ-TLPSPPATPPSQATTSLGSPTLQATHSFLPSPPLSPLATPP 393
Query: 987 ---------DPLGPSPVPEASPPTPSLLRHSFQS 1011
PL P P ASPP L S Q+
Sbjct: 394 PQAPPALALPPLQAPPSPPASPPLSPLATPSPQA 427
>gi|14602439 Williams Beuren syndrome chromosome region 14 isoform
delta [Homo sapiens]
Length = 831
Score = 52.4 bits (124), Expect = 2e-06
Identities = 62/214 (28%), Positives = 83/214 (38%), Gaps = 36/214 (16%)
Query: 807 PPQLLIPPLGTFG------PPDLSPRIVDGIEDSGSTAEAPSFRFSRRPELPRPRSQAPP 860
P L +PP + PDL+P + ++D ++ F SR P+ P P + P
Sbjct: 264 PSPLQLPPEDAYVGNADMIQPDLTP-LQPSLDDFMDISDF--FTNSRLPQPPMPSNFPEP 320
Query: 861 TGTRPSPELASEAEEVKEKVCRLNQEISRLNQEVSQLSRELRHIMG--LLQARLGPPGHP 918
P + + L EV S + H+ G LQAR PG
Sbjct: 321 PSFSPVVDSLFSS--------------GTLGPEVPPASSAMTHLSGHSRLQARNSCPGPL 366
Query: 919 AGSAWT------PDPPCPQLRPPCLSPCASRPPPSLQDTTLAEVHCPASVGTMETGTALL 972
SA+ P+ P P+L PP + P PP + L E P M TALL
Sbjct: 367 DSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGL-EPCPPPPFPPMAPPTALL 425
Query: 973 DLRPSILP--PYPSEPDPLG--PSPVPEASPPTP 1002
P P P+P+ P G P P P A PPTP
Sbjct: 426 QEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTP 459
Score = 36.2 bits (82), Expect = 0.16
Identities = 80/367 (21%), Positives = 110/367 (29%), Gaps = 61/367 (16%)
Query: 683 DLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITEAESGAEP-------- 734
DL L SDT S L P ++ ++D P +T + +
Sbjct: 244 DLNCFLSDISDTLFTMTQSGPSPLQLPPEDAYVGNADMIQPDLTPLQPSLDDFMDISDFF 303
Query: 735 --GGGPRPRRPLLLP---NLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLSPALAGQ 789
P+P P P + SP LG E+PP S+ ++ S L +
Sbjct: 304 TNSRLPQPPMPSNFPEPPSFSPVVDSLFSSGTLGPEVPPASSAMTHLSGHSRLQARNSCP 363
Query: 790 GHSAS----------PHGP-PRCSAAWKPPQLL-------IPPLGTFGPPDLSPRIVDGI 831
G S P P PR PP LL +P L PP P
Sbjct: 364 GPLDSSAFLSSDFLLPEDPKPRLPPPPVPPPLLHYPPPAKVPGLEPCPPPPFPPMAPPTA 423
Query: 832 EDSGSTAEAPSFRFSRRPELPRPRSQAPPTGTRPSPELASEAEEVKEKVCRLNQEISRLN 891
+P F F P P P P+P+ + L
Sbjct: 424 LLQEEPLFSPRFPFPTVPPAPGVSPLPAPAAFPPTPQSVPSPAPTPFPIELLP------- 476
Query: 892 QEVSQLSRELRHIMGLLQARLGPP-GHPAGSAWTPDPPCPQLRPPCLSPCASRPP----- 945
+G + GP P G P P + PP L+P + PP
Sbjct: 477 -------------LGYSEPAFGPCFSMPRGKPPAPSPRGQKASPPTLAPATASPPTTAGS 523
Query: 946 --PSLQDTTLAEVHCPASVGTMETGTALLD--LRPSILPPYPSEPDPLGPSPVPEASPPT 1001
P L A A + + T L +P +P P P+P P PP
Sbjct: 524 NNPCLTQLLTAAKPEQALEPPLVSSTLLRSPGSPQETVPEFPCTFLPPTPAPTPPRPPPG 583
Query: 1002 PSLLRHS 1008
P+ L S
Sbjct: 584 PATLAPS 590
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 45,533,871
Number of Sequences: 37866
Number of extensions: 2605061
Number of successful extensions: 18917
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 104
Number of HSP's successfully gapped in prelim test: 743
Number of HSP's that attempted gapping in prelim test: 14561
Number of HSP's gapped (non-prelim): 3966
length of query: 1017
length of database: 18,247,518
effective HSP length: 112
effective length of query: 905
effective length of database: 14,006,526
effective search space: 12675906030
effective search space used: 12675906030
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.