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Search of human proteins with 6912330
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|6912330 deafness locus associated putative guanine
nucleotide exchange factor [Homo sapiens]
(458 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|6912330 deafness locus associated putative guanine nucleotide... 964 0.0
gi|7657152 hect domain and RLD 3 [Homo sapiens] 148 9e-36
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 145 1e-34
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 145 1e-34
gi|126032348 hect domain and RLD 2 [Homo sapiens] 134 2e-31
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 123 4e-28
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 119 6e-27
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 119 6e-27
gi|61563742 hect domain and RLD 6 [Homo sapiens] 105 1e-22
gi|4557445 regulator of chromosome condensation and BTB domain c... 104 2e-22
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 103 4e-22
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 97 4e-20
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 97 4e-20
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 97 4e-20
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 97 4e-20
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 97 4e-20
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 97 4e-20
gi|110825982 hect domain and RLD 5 [Homo sapiens] 94 3e-19
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 90 4e-18
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 90 4e-18
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 86 9e-17
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 85 1e-16
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 80 3e-15
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 79 9e-15
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 78 2e-14
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 77 4e-14
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 77 4e-14
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 74 2e-13
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens] 73 6e-13
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 67 4e-11
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 964 bits (2492), Expect = 0.0
Identities = 458/458 (100%), Positives = 458/458 (100%)
Query: 1 MEREPSASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGH 60
MEREPSASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGH
Sbjct: 1 MEREPSASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGH 60
Query: 61 SAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENG 120
SAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENG
Sbjct: 61 SAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENG 120
Query: 121 QVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG 180
QVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG
Sbjct: 121 QVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG 180
Query: 181 LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNK 240
LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNK
Sbjct: 181 LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNK 240
Query: 241 HGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRK 300
HGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRK
Sbjct: 241 HGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRK 300
Query: 301 LETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVCYSWGWNE 360
LETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVCYSWGWNE
Sbjct: 301 LETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVCYSWGWNE 360
Query: 361 HGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLPAHPALVQDPKVTYLSPD 420
HGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLPAHPALVQDPKVTYLSPD
Sbjct: 361 HGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLPAHPALVQDPKVTYLSPD 420
Query: 421 AIEDTESQKAMDKERNWKERQSETSTQSQSDWSRNGGL 458
AIEDTESQKAMDKERNWKERQSETSTQSQSDWSRNGGL
Sbjct: 421 AIEDTESQKAMDKERNWKERQSETSTQSQSDWSRNGGL 458
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 148 bits (374), Expect = 9e-36
Identities = 112/371 (30%), Positives = 173/371 (46%), Gaps = 37/371 (9%)
Query: 17 LFAWGANSYGQLGLG-HKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
+ WG S GQ G+ + + ++ Q+ F RSV+ + GG HS + + G+++ CGL
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGL 60
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
N GQ LGH + +L I VACG ++ L++ GQ+ S G+ S GQLG+
Sbjct: 61 NTKGQ--LGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGL 118
Query: 136 PHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTL 194
VP+ I+ L+++ ++ ++ G H +A A G F WG + +L G+
Sbjct: 119 MTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWG---KNSHGQLGLGKEF 175
Query: 195 PLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVP 254
P + P RV LE V AG HS +L+ +G V+ WG N GQL L
Sbjct: 176 P---SQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQLG-----LSDE 227
Query: 255 QKIEAHC----FQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLE 310
+ E+ C + +KV I G H T++G +FT+G GQLG +
Sbjct: 228 KDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGH----------D 277
Query: 311 KQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII--GGVCYSWGWNEHGMCGDGT 368
+ + R M S T+++CG +H LA + G+ Y++G G G G
Sbjct: 278 SMNDEVNPRRVLELMGSE------VTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGH 331
Query: 369 EANVWAPKPVQ 379
NV P PV+
Sbjct: 332 TCNVKCPSPVK 342
Score = 102 bits (254), Expect = 7e-22
Identities = 83/305 (27%), Positives = 130/305 (42%), Gaps = 41/305 (13%)
Query: 103 IQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGL 162
+++VACG + ++ L E+G+V +CG N+ GQLG H Q L + ++ +A G
Sbjct: 36 VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADQHIIHVACGE 93
Query: 163 RHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKE---PSRVTGLENSKAMCVLA 219
H++A + G +F WG G GQ L L T P + L + V
Sbjct: 94 SHSLALSDRGQLFSWGAG--------SDGQ-LGLMTTEDSVAVPRLIQKLNQQTILQVSC 144
Query: 220 GSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVA 279
G+ H +L G+ + WG N HGQL F + + + +G H A
Sbjct: 145 GNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFA 204
Query: 280 QTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATE-- 337
+ +G +F WG + GQLG +++D PC H T+
Sbjct: 205 LSLSGAVFGWGMNNAGQLGLS---------DEKDRESPC-----------HVKLLRTQKV 244
Query: 338 --VSCGSEHNLAII--GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393
+SCG EH + GGV +++G G G + + P+ V L+ S + CG
Sbjct: 245 VYISCGEEHTAVLTKSGGV-FTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGR 303
Query: 394 GHSLA 398
H+LA
Sbjct: 304 QHTLA 308
Score = 99.8 bits (247), Expect = 5e-21
Identities = 79/243 (32%), Positives = 109/243 (44%), Gaps = 13/243 (5%)
Query: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVT 65
S S A LF+WGA S GQLGL ED + +L +++ +++ G H +
Sbjct: 94 SHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALA 153
Query: 66 DGGDLFVCGLNKDGQLGLGHTEDIPYFTP---CKSLFGCPIQQVACGWDFTIMLTENGQV 122
G F G N GQLGLG ++ P +SL G P+ QVA G + L+ +G V
Sbjct: 154 ADGQFFTWGKNSHGQLGLG--KEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAV 211
Query: 123 LSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLA 182
G N+ GQLG+ R L +KVV I+ G H T SG VF +G G
Sbjct: 212 FGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAG-- 269
Query: 183 SCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHS-ASLTDAGEVYVWGSNKH 241
SCG+ P RV L S+ + G H+ A + +G +Y +G
Sbjct: 270 SCGQLGHDSMN-----DEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGAR 324
Query: 242 GQL 244
GQL
Sbjct: 325 GQL 327
Score = 79.3 bits (194), Expect = 7e-15
Identities = 73/285 (25%), Positives = 117/285 (41%), Gaps = 35/285 (12%)
Query: 122 VLSCGSNSFGQLGVPHGPRRCVV-PQAIELHKEKVVC-IAAGLRHAVAATASGIVFQWGT 179
+L G S GQ G+ + V PQ ++ V +A G H+V G V+
Sbjct: 1 MLCWGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVY---- 56
Query: 180 GLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSN 239
+CG GQ L +P ++ L + + V G HS +L+D G+++ WG+
Sbjct: 57 ---TCGLNT-KGQ-LGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAG 111
Query: 240 KHGQLA--NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQL 297
GQL + VP+ I+ + + + G H +A G+ FTWG+ +GQL
Sbjct: 112 SDGQLGLMTTEDSVAVPRLIQK--LNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQL 169
Query: 298 GRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGA--TEVSCGSEHNLAI-IGGVCY 354
G E P + P L G +V+ G H+ A+ + G +
Sbjct: 170 GLGKEF-----------------PSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVF 212
Query: 355 SWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLAL 399
WG N G G E + +P V+ L + + + CG H+ L
Sbjct: 213 GWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVL 257
Score = 41.6 bits (96), Expect = 0.002
Identities = 34/119 (28%), Positives = 56/119 (47%), Gaps = 5/119 (4%)
Query: 14 AAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHS-AVVTDGGDLFV 72
+ +F +GA S GQLG D + P+++ + V +I G H+ A V G ++
Sbjct: 260 SGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSE-VTQIACGRQHTLAFVPSSGLIYA 318
Query: 73 CGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWD-FTIMLTENGQVLSCGSNSF 130
G GQLG GHT ++ +P K + Q++ D F + + Q+ S G +F
Sbjct: 319 FGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFKYHIVK--QIFSGGDQTF 375
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 145 bits (365), Expect = 1e-34
Identities = 120/374 (32%), Positives = 178/374 (47%), Gaps = 43/374 (11%)
Query: 17 LFAWGANSYGQLGLGH-KEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
+ WG S+GQLGLG E+++L + +DF + VR + G H+ V D G ++ CG
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
N GQ LGH + +L I V+CG T+ L + GQV + G +S GQLG+
Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118
Query: 136 PHGPRRCV-VPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGT---GLASCGRRLCP 190
G C+ VP+ I+ L ++V +A G H++A + + VF WG G G C
Sbjct: 119 V-GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD-CK 176
Query: 191 GQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAA 249
QT P + L M V AG HS LT +G ++ WG NK GQL N+
Sbjct: 177 KQT--------SPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228
Query: 250 FLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKL 309
VP +++ +++K+ I G H A T+ G +FT+G YGQLG ++E
Sbjct: 229 DRYVPNLLKS--LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE---- 282
Query: 310 EKQDSFLPCSRPPNSMPSSPHCLTGA--TEVSCGSEHNLAII--GGVCYSWGWNEHGMCG 365
P L G+ TE++CG +H A + G YS+G +G G
Sbjct: 283 --------------INPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328
Query: 366 DGTEANVWAPKPVQ 379
G+ +N +P V+
Sbjct: 329 TGSTSNRKSPFTVK 342
Score = 95.9 bits (237), Expect = 7e-20
Identities = 77/286 (26%), Positives = 127/286 (44%), Gaps = 37/286 (12%)
Query: 122 VLSCGSNSFGQLGVPHGPRRCVV-PQAIELH-KEKVVCIAAGLRHAVAATASGIVFQWGT 179
+L G+ SFGQLG+ V+ P+ + ++V + GLRH V G V+ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 180 G-LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238
L G + K+P +V L+ + V G H+ +L D G+VY WG
Sbjct: 61 NDLGQLGHEK----------SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGL 110
Query: 239 NKHGQ--LANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQ 296
+ GQ L + VP+ I++ + ++ + G+ H +A ++ ++F WG+ YGQ
Sbjct: 111 DSDGQLGLVGSEECIRVPRNIKS--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ 168
Query: 297 LGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGA--TEVSCGSEHNLAI-IGGVC 353
LG G +KQ S P L G +V+ G H+ + + G
Sbjct: 169 LGL------GTDCKKQTS-----------PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAI 211
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLAL 399
+ WG N+ G G E + + P +++L S + + CG H+ AL
Sbjct: 212 FGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Score = 87.4 bits (215), Expect = 2e-17
Identities = 62/174 (35%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Query: 8 SEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDG 67
S A A+ +F WG N YGQLGLG QL ++ GG HS V+T
Sbjct: 149 SLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLS 208
Query: 68 GDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS 127
G +F G NK GQLGL D KSL I + CG D T LT+ G V + G+
Sbjct: 209 GAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA 268
Query: 128 NSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVA-ATASGIVFQWGTG 180
+GQLG + EL V IA G +H A +SG ++ +G G
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLG 322
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 145 bits (365), Expect = 1e-34
Identities = 120/374 (32%), Positives = 178/374 (47%), Gaps = 43/374 (11%)
Query: 17 LFAWGANSYGQLGLGH-KEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
+ WG S+GQLGLG E+++L + +DF + VR + G H+ V D G ++ CG
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
N GQ LGH + +L I V+CG T+ L + GQV + G +S GQLG+
Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL 118
Query: 136 PHGPRRCV-VPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGT---GLASCGRRLCP 190
G C+ VP+ I+ L ++V +A G H++A + + VF WG G G C
Sbjct: 119 V-GSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD-CK 176
Query: 191 GQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAA 249
QT P + L M V AG HS LT +G ++ WG NK GQL N+
Sbjct: 177 KQT--------SPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEN 228
Query: 250 FLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKL 309
VP +++ +++K+ I G H A T+ G +FT+G YGQLG ++E
Sbjct: 229 DRYVPNLLKS--LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHE---- 282
Query: 310 EKQDSFLPCSRPPNSMPSSPHCLTGA--TEVSCGSEHNLAII--GGVCYSWGWNEHGMCG 365
P L G+ TE++CG +H A + G YS+G +G G
Sbjct: 283 --------------INPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328
Query: 366 DGTEANVWAPKPVQ 379
G+ +N +P V+
Sbjct: 329 TGSTSNRKSPFTVK 342
Score = 95.9 bits (237), Expect = 7e-20
Identities = 77/286 (26%), Positives = 127/286 (44%), Gaps = 37/286 (12%)
Query: 122 VLSCGSNSFGQLGVPHGPRRCVV-PQAIELH-KEKVVCIAAGLRHAVAATASGIVFQWGT 179
+L G+ SFGQLG+ V+ P+ + ++V + GLRH V G V+ G
Sbjct: 1 MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 180 G-LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238
L G + K+P +V L+ + V G H+ +L D G+VY WG
Sbjct: 61 NDLGQLGHEK----------SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGL 110
Query: 239 NKHGQ--LANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQ 296
+ GQ L + VP+ I++ + ++ + G+ H +A ++ ++F WG+ YGQ
Sbjct: 111 DSDGQLGLVGSEECIRVPRNIKS--LSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQ 168
Query: 297 LGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGA--TEVSCGSEHNLAI-IGGVC 353
LG G +KQ S P L G +V+ G H+ + + G
Sbjct: 169 LGL------GTDCKKQTS-----------PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAI 211
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLAL 399
+ WG N+ G G E + + P +++L S + + CG H+ AL
Sbjct: 212 FGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Score = 87.4 bits (215), Expect = 2e-17
Identities = 62/174 (35%), Positives = 79/174 (45%), Gaps = 1/174 (0%)
Query: 8 SEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDG 67
S A A+ +F WG N YGQLGLG QL ++ GG HS V+T
Sbjct: 149 SLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLS 208
Query: 68 GDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS 127
G +F G NK GQLGL D KSL I + CG D T LT+ G V + G+
Sbjct: 209 GAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGA 268
Query: 128 NSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVA-ATASGIVFQWGTG 180
+GQLG + EL V IA G +H A +SG ++ +G G
Sbjct: 269 GGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLG 322
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 134 bits (337), Expect = 2e-31
Identities = 122/405 (30%), Positives = 178/405 (43%), Gaps = 33/405 (8%)
Query: 1 MEREPSA-SEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGG 59
M R P + +A + ++ WG N GQLG V +P R V+ I GG
Sbjct: 3937 MNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLI-GGEQ 3995
Query: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVAC--GWDFTIMLT 117
VT G L+ G G+LG+G TE + T +S+ I++VA G + L+
Sbjct: 3996 TLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALS 4055
Query: 118 ENGQVLSCGSNSFGQLGVPHGPRR-CVVPQAIE-LHKEKVVCIAAGLRHAVAATASGIVF 175
G+V S G G+LG HG R C P+ IE L +VV +AAG H+ TA+G ++
Sbjct: 4056 SEGEVYSWGEAEDGKLG--HGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 4113
Query: 176 QWGTG-LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVY 234
WG G G Q P A + RV + +G + LTD V+
Sbjct: 4114 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACG------SGDAQTLCLTDDDTVW 4167
Query: 235 VWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRAD 293
WG +G+L + VP KI++ V + G VA T++G ++TWG+ D
Sbjct: 4168 SWGDGDYGKLGRGGSDGCKVPMKIDS--LTGLGVVKVECGSQFSVALTKSGAVYTWGKGD 4225
Query: 294 YGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVC 353
Y +LG + + + +Q L + S HC+ C +E G
Sbjct: 4226 YHRLGHGSDDHV--RRPRQVQGLQGKKVIAIATGSLHCV-------CCTED------GEV 4270
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLA 398
Y+WG N+ G GDGT + P+ V AL V CG+ H+LA
Sbjct: 4271 YTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLA 4315
Score = 132 bits (332), Expect = 7e-31
Identities = 130/448 (29%), Positives = 191/448 (42%), Gaps = 59/448 (13%)
Query: 10 AAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGD 69
AA +F WG N QLG G K + ++ +V ++ GG VT G
Sbjct: 2954 AATIRTKVFVWGLNDKDQLG-GLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGK 3012
Query: 70 LFVCGLNKDGQLGLGHTED-IPYFTPCKSLFGCPIQQVAC--GWDFTIMLTENGQVLSCG 126
++ CG +G+LGLG + +P +L +++VA G LT +G+V S G
Sbjct: 3013 VYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG 3072
Query: 127 SNSFGQLGVPHGPR-RCVVPQAIELHKEKVVC-IAAGLRHAVAATASGIVFQWGTGLASC 184
G+LG H R C P+ IE K K + IA G H+ A T+SG ++ WG G
Sbjct: 3073 EGDDGKLG--HFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG- 3129
Query: 185 GRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSD--HSASLTDAGEVYVWGSNKHG 242
RL G T +P V L + + V GS + +LTD G V+ WG G
Sbjct: 3130 --RLGHGDNT----TQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFG 3183
Query: 243 QLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLG--- 298
+L + +PQ IE + V I G +A T++G ++TWG+ DY +LG
Sbjct: 3184 KLGRGGSEGCNIPQNIER--LNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLGHGS 3241
Query: 299 ----RKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
RK + EG + +K V+ G+ H LA+ G
Sbjct: 3242 DVHVRKPQVVEGLRGKK-----------------------IVHVAVGALHCLAVTDSGQV 3278
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLPAHPALVQDPK 413
Y+WG N+HG G+GT P VQ L V CG+ HS+A + V +P
Sbjct: 3279 YAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVHEPV 3338
Query: 414 VTYLSPDAI--------EDTESQKAMDK 433
+ + D + D +S A +K
Sbjct: 3339 LFQTARDPLGASYLGVPSDADSSAASNK 3366
Score = 109 bits (272), Expect = 6e-24
Identities = 92/316 (29%), Positives = 145/316 (45%), Gaps = 43/316 (13%)
Query: 95 CKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKE 153
C+ L + Q+AC ++L+ NG+V + NS + PQ ++ L
Sbjct: 445 CEGLANLGVTQIACAEKRFLILSRNGRVYTQAYNS-----------DTLAPQLVQGLASR 493
Query: 154 KVVCIAAGL--RHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLEN 211
+V IAA H +A A+G V+ WG G G RL G T+PL +EP ++
Sbjct: 494 NIVKIAAHSDGHHYLALAATGEVYSWGCG---DGGRLGHGDTVPL----EEPKVISAFSG 546
Query: 212 SKA----MCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEK 266
+A + + GS +SA++T GE+Y WG +G+L + ++ +P +
Sbjct: 547 KQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVI 606
Query: 267 VTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMP 326
A SG +A TE G++++WG DYG+LGR +G K K L
Sbjct: 607 DVACGSGDAQTLAVTENGQVWSWGDGDYGKLGR--GGSDGCKTPKLIEKLQD-------- 656
Query: 327 SSPHCLTGATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSS 385
+V CGS+ ++A+ G YSWG ++ G GTE +V PK ++ L
Sbjct: 657 ------LDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKK 710
Query: 386 GLLVGCGAGHSLALCQ 401
+ V G+ H LAL +
Sbjct: 711 VIDVAAGSTHCLALTE 726
Score = 106 bits (264), Expect = 5e-23
Identities = 80/240 (33%), Positives = 116/240 (48%), Gaps = 14/240 (5%)
Query: 10 AAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRS---VRRITGGGGHSAVVTD 66
A A +++WG G+LG G + P+ ++ F ++ V I G +SA +T
Sbjct: 509 ALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITA 568
Query: 67 GGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDF--TIMLTENGQVLS 124
G+L+ G G+LG G +ED L G + VACG T+ +TENGQV S
Sbjct: 569 EGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWS 628
Query: 125 CGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLAS 183
G +G+LG G C P+ IE L VV + G + ++A T G V+ WG G
Sbjct: 629 WGDGDYGKLG-RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKG--- 684
Query: 184 CGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQ 243
+RL G + + P + GL+ K + V AGS H +LT+ EV+ WGSN Q
Sbjct: 685 DNQRLGHGTEEHVRY----PKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
Score = 89.0 bits (219), Expect = 8e-18
Identities = 71/226 (31%), Positives = 107/226 (47%), Gaps = 12/226 (5%)
Query: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGG-GGHSAVV 64
S S A ++ L+ WG YG+LG G L P+ + R ++ G + +
Sbjct: 3109 SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLAL 3168
Query: 65 TDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLS 124
TD G +F G G+LG G +E + L G + Q+ CG F++ LT++G V +
Sbjct: 3169 TDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT 3228
Query: 125 CGSNSFGQLGVPHGPRRCV-VPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLA 182
G + +LG HG V PQ +E L +K+V +A G H +A T SG V+ WG
Sbjct: 3229 WGKGDYFRLG--HGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDN-- 3284
Query: 183 SCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLT 228
G++ T+ ++P+ V GLE K V GS HS + T
Sbjct: 3285 DHGQQGNGTTTV-----NRKPTLVQGLEGQKITRVACGSSHSVAWT 3325
Score = 84.3 bits (207), Expect = 2e-16
Identities = 74/276 (26%), Positives = 119/276 (43%), Gaps = 23/276 (8%)
Query: 32 HKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDG-GDLFVCGLNKDGQLGLGHTEDIP 90
+ D L PQ + V+ GH + G+++ G G+LG G T +P
Sbjct: 477 YNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDT--VP 534
Query: 91 YFTP-CKSLF-----GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVV 144
P S F G + +ACG ++ +T G++ + G ++G+LG +
Sbjct: 535 LEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIP 594
Query: 145 PQAIELHKEKVVCIAAGLRHA--VAATASGIVFQWGTG-LASCGRRLCPGQTLPLFFTAK 201
L KV+ +A G A +A T +G V+ WG G GR G K
Sbjct: 595 MLVAGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--------CK 646
Query: 202 EPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN-EAAFLPVPQKIEAH 260
P + L++ + V GS S +LT G+VY WG + +L + + P+ +E
Sbjct: 647 TPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG- 705
Query: 261 CFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQ 296
Q +KV + +G TH +A TE ++ +WG D Q
Sbjct: 706 -LQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
Score = 81.3 bits (199), Expect = 2e-15
Identities = 67/228 (29%), Positives = 103/228 (45%), Gaps = 12/228 (5%)
Query: 8 SEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGG-GHSAVVTD 66
S A A L+ WG +YG+LG G ED +P + + + G G + VT+
Sbjct: 563 SAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTLAVTE 622
Query: 67 GGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCG 126
G ++ G G+LG G ++ + L + +V CG F+I LT++GQV S G
Sbjct: 623 NGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWG 682
Query: 127 SNSFGQLGVPHGPRRCV-VPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASC 184
+LG HG V P+ +E L +KV+ +AAG H +A T V WG+ C
Sbjct: 683 KGDNQRLG--HGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSN-DQC 739
Query: 185 GRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGE 232
TL + T EP+ + GL+ + + G S + + E
Sbjct: 740 QH----FDTLRV--TKPEPAALPGLDTKHIVGIACGPAQSFAWSSCSE 781
Score = 79.7 bits (195), Expect = 5e-15
Identities = 75/297 (25%), Positives = 123/297 (41%), Gaps = 35/297 (11%)
Query: 111 DFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATA 170
D+T+ +G + G N GQLG G + V L + V + G + A TA
Sbjct: 3943 DWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTA 4002
Query: 171 SGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENS--KAMCVLAGSDHSASLT 228
G ++ G G G RL G T + P+ + +++ K + V +G H +L+
Sbjct: 4003 DGKLYATGYG---AGGRLGIGGTE----SVSTPTLLESIQHVFIKKVAVNSGGKHCLALS 4055
Query: 229 DAGEVYVWGSNKHGQLAN-EAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMF 287
GEVY WG + G+L + + P+ IE+ + +V + +G H T G ++
Sbjct: 4056 SEGEVYSWGEAEDGKLGHGNRSPCDRPRVIES--LRGIEVVDVAAGGAHSACVTAAGDLY 4113
Query: 288 TWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG--ATEVSCGSEHN 345
TWG+ YG+LG + +D P L G +++CGS
Sbjct: 4114 TWGKGRYGRLGHS---------DSEDQL---------KPKLVEALQGHRVVDIACGSGDA 4155
Query: 346 LAII---GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLAL 399
+ +SWG ++G G G P + +L + V CG+ S+AL
Sbjct: 4156 QTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVAL 4212
Score = 71.6 bits (174), Expect = 1e-12
Identities = 74/299 (24%), Positives = 121/299 (40%), Gaps = 45/299 (15%)
Query: 114 IMLTENGQVLSCGSNSFGQLG----VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAAT 169
+ L G+V S G G+LG VP + + + + + VV IA G ++ A T
Sbjct: 508 LALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAIT 567
Query: 170 ASGIVFQWGTG-LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASL- 227
A G ++ WG G G + +P+ V GL+ K + V GS + +L
Sbjct: 568 AEGELYTWGRGNYGRLGHGSSEDEAIPML--------VAGLKGLKVIDVACGSGDAQTLA 619
Query: 228 -TDAGEVYVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGK 285
T+ G+V+ WG +G+L + P+ IE Q+ V + G +A T+ G+
Sbjct: 620 VTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEK--LQDLDVVKVRCGSQFSIALTKDGQ 677
Query: 286 MFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG-----ATEVSC 340
+++WG+ D +LG E + + P L G +V+
Sbjct: 678 VYSWGKGDNQRLGHGTEEHVRY---------------------PKLLEGLQGKKVIDVAA 716
Query: 341 GSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLA 398
GS H LA+ +SWG N+ D P + L + + + CG S A
Sbjct: 717 GSTHCLALTEDSEVHSWGSNDQCQHFDTLRVTKPEPAALPGLDTKHIVGIACGPAQSFA 775
Score = 63.9 bits (154), Expect = 3e-10
Identities = 52/206 (25%), Positives = 86/206 (41%), Gaps = 26/206 (12%)
Query: 201 KEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA---NEAAFLPVPQKI 257
K P+ L + + ++ G ++T G++Y G G+L E+ P +
Sbjct: 3974 KVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLES 4033
Query: 258 EAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLP 317
H F K A+ SG H +A + G++++WG A+ G+LG + P
Sbjct: 4034 IQHVFI--KKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRS-------------P 4078
Query: 318 CSRPPNSMPSSPHCLTG--ATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA 374
C RP L G +V+ G H+ + G Y+WG +G G +
Sbjct: 4079 CDRP-----RVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLK 4133
Query: 375 PKPVQALLSSSGLLVGCGAGHSLALC 400
PK V+AL + + CG+G + LC
Sbjct: 4134 PKLVEALQGHRVVDIACGSGDAQTLC 4159
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 123 bits (308), Expect = 4e-28
Identities = 115/401 (28%), Positives = 179/401 (44%), Gaps = 45/401 (11%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
++ WGA +GQL + +V++P F + +++ G + V+ G + CG
Sbjct: 3999 VYLWGAGRHGQLAEAGR-NVMVPAAAPSFSQ---AQQVICGQNCTFVIQANGTVLACGEG 4054
Query: 77 KDGQLGLGHTEDIPYFTPCKSLFGCPIQQV--ACGWD-FTIMLTENGQVLSCGSNSFGQL 133
G+LG G+++D+ T +L G + Q+ +CG D ++ LTE+G+V S G +G+L
Sbjct: 4055 SYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKL 4114
Query: 134 GVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQT 193
G + R+ Q L E+VV ++ G +H+ T+ G +F +G G RL G T
Sbjct: 4115 GHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYG---RLGLGNT 4171
Query: 194 LPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLT-DAGEVYVWGSNKHGQLA-NEAAFL 251
K P RVT LE + V G +H+ +++ D V+ +G +G+L +
Sbjct: 4172 ----SNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAK 4227
Query: 252 PVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEK 311
PQKI+ C K A G VA T+ G ++T+G
Sbjct: 4228 SSPQKIDVLCGIGIKKVA--CGTQFSVALTKDGHVYTFG--------------------- 4264
Query: 312 QDSF--LPCSRPPN-SMPSSPHCLTGA--TEVSCGSEHNLAII-GGVCYSWGWNEHGMCG 365
QD LP R N + P L G +V+ G+EH LA+ G Y+WG N G G
Sbjct: 4265 QDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLG 4324
Query: 366 DGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLPAHP 406
G +V P V L + + G HS A P P
Sbjct: 4325 LGHTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTAPPVPP 4365
Score = 106 bits (265), Expect = 4e-23
Identities = 110/400 (27%), Positives = 169/400 (42%), Gaps = 49/400 (12%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
++ WG+NS QL G +E +L P+ F + I G + V++ G + CG
Sbjct: 374 VYVWGSNSSHQLVEGTQEKILQPKLAPSF---SDAQTIEAGQYCTFVISTDGSVRACGKG 430
Query: 77 KDGQLGLGHTEDIP-----YFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFG 131
G+LGLG + + F P +S+ + + G T+ T G+V S G +G
Sbjct: 431 SYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDG--HTLAFTTEGEVFSWGDGDYG 488
Query: 132 QLGVPHGPRRC-VVPQAIE--LHKEKVVCIAAGLRHAVAATASGIVFQWGTG-LASCGRR 187
+LG HG P+ I+ L + VVC++AG RH+ A T G ++ WG G G
Sbjct: 489 KLG--HGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHG 546
Query: 188 LCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLT-DAGEVYVWGSNKHGQLAN 246
+ +P K+ S V V GS H+ +L+ D V+ +G +G+L +
Sbjct: 547 DSNSRNIPTL--VKDISNVGE--------VSCGSSHTIALSKDGRTVWSFGGGDNGKLGH 596
Query: 247 -EAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYE 305
+ + P+ IEA Q + + +G +A T TG+++ WG G T
Sbjct: 597 GDTNRVYKPKVIEA--LQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATAL 654
Query: 306 GWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVCYSWGWNEHGMC 364
KL ++ T +VS G H LA+ Y+WG N G C
Sbjct: 655 RPKLIEE-----------------LAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQC 697
Query: 365 GDGTEAN-VWAPKPVQALLSSSGLLVGCGAGHSLALCQLP 403
G G + PK V L + + G HSLA LP
Sbjct: 698 GQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWTALP 737
Score = 103 bits (257), Expect = 3e-22
Identities = 95/348 (27%), Positives = 151/348 (43%), Gaps = 22/348 (6%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
+F+WG YG+LG G+ P+ + + + V ++ G HSA VT+ G+L+ G
Sbjct: 479 VFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEG 538
Query: 77 KDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQ-VLSCGSNSFGQLGV 135
G+LG G + T K + + +V+CG TI L+++G+ V S G G+LG
Sbjct: 539 DFGRLGHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLG- 595
Query: 136 PHG-PRRCVVPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLA-SCGRRLCPGQ 192
HG R P+ IE L + + AG + ++A T++G V+ WG G CG
Sbjct: 596 -HGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEA--- 651
Query: 193 TLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLP 252
TA P + L ++ + V G H +L+ EVY WG+N GQ + P
Sbjct: 652 ------TALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGP 705
Query: 253 VPQKIEAHCFQNEKVTAIWSGWTHLVAQT---ETGKMFTWGRADYGQLGRKLETYEGWKL 309
+ + + + I +G +H +A T ++ W R L ++ L
Sbjct: 706 ITKPKKVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFL 765
Query: 310 EKQDSFLPCSRPPNSMPSS--PHCLTGATEVSCGSEHNLAIIGGVCYS 355
E+ + PP PSS H + LA+ GGV S
Sbjct: 766 ERYCDKINSEIPPLPFPSSREHHSFLKLCLKLLSNHLALALAGGVATS 813
Score = 99.8 bits (247), Expect = 5e-21
Identities = 77/248 (31%), Positives = 119/248 (47%), Gaps = 29/248 (11%)
Query: 8 SEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDG 67
S A + +F+WG YG+LG G+ + P+Q+ + + V +++ G HSAVVT
Sbjct: 4094 SMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQI-EALQGEEVVQMSCGFKHSAVVTSD 4152
Query: 68 GDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENG-QVLSCG 126
G LF G G+LGLG+T + +L G I QVACG + T+ ++ +G V + G
Sbjct: 4153 GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
Query: 127 SNSFGQLGVPHGPRRCVVPQAIELHKEKVVC------IAAGLRHAVAATASGIVFQWG-- 178
+G+LG+ + + PQ I+ V+C +A G + +VA T G V+ +G
Sbjct: 4213 DGDYGKLGLGNSTAKS-SPQKID-----VLCGIGIKKVACGTQFSVALTKDGHVYTFGQD 4266
Query: 179 --TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVW 236
GL R P ++ L V G++H+ +L G+VY W
Sbjct: 4267 RLIGLPEGRAR-----------NHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAW 4315
Query: 237 GSNKHGQL 244
GSN GQL
Sbjct: 4316 GSNSEGQL 4323
Score = 92.4 bits (228), Expect = 7e-19
Identities = 74/290 (25%), Positives = 130/290 (44%), Gaps = 13/290 (4%)
Query: 13 AAAALFAWGANSYGQLGLGHKED---VLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGD 69
A + A G SYG+LG G+ +D + + L F + V G GHS +T+ G+
Sbjct: 4044 ANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTS-CGSDGHSMALTESGE 4102
Query: 70 LFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNS 129
+F G G+LG G+++ ++L G + Q++CG+ + ++T +G++ + G+
Sbjct: 4103 VFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGD 4162
Query: 130 FGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLC 189
+G+LG+ + + + + L ++ +A GL H +A +A G + W G G+
Sbjct: 4163 YGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMV-WAFGDGDYGKLGL 4221
Query: 190 PGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNK-HGQLANEA 248
T P ++ L V G+ S +LT G VY +G ++ G A
Sbjct: 4222 GNST-----AKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRA 4276
Query: 249 AFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLG 298
PQ+I + + G H +A G ++ WG GQLG
Sbjct: 4277 RNHNRPQQIPV--LAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLG 4324
Score = 72.4 bits (176), Expect = 8e-13
Identities = 59/224 (26%), Positives = 100/224 (44%), Gaps = 15/224 (6%)
Query: 8 SEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHS-AVVTD 66
S A L+ WG +G+LG G +P + D +V ++ G H+ A+ D
Sbjct: 523 SAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI---SNVGEVSCGSSHTIALSKD 579
Query: 67 GGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCG 126
G ++ G +G+LG G T + ++L G I++V G ++ LT GQV + G
Sbjct: 580 GRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWG 639
Query: 127 SNSFGQLGVPHGPRRCVVPQAI-ELHKEKVVCIAAGLRHAVAATASGIVFQWG-TGLASC 184
+ LG + P+ I EL ++V ++ G H +A + V+ WG + C
Sbjct: 640 CGAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQC 697
Query: 185 GRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLT 228
G+ G +P +V+GL+ + AG+ HS + T
Sbjct: 698 GQGNSTG-------PITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 119 bits (298), Expect = 6e-27
Identities = 89/294 (30%), Positives = 144/294 (48%), Gaps = 21/294 (7%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
L+ +G+N++GQLGLG K + P + KP V+ G H+ V T+GG+++ G N
Sbjct: 56 LYMFGSNNWGQLGLGSKSAISKPTCVKAL-KPEKVKLAACGRNHTLVSTEGGNVYATGGN 114
Query: 77 KDGQLGLGHTED------IPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSF 130
+GQLGLG TE+ I +FT I+Q++ G + + LTE+G++ G NS
Sbjct: 115 NEGQLGLGDTEERNTFHVISFFTSEHK-----IKQLSAGSNTSAALTEDGRLFMWGDNSE 169
Query: 131 GQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCP 190
GQ+G+ + CV PQ + + K V I+ G H+ T G ++ +G G+ P
Sbjct: 170 GQIGLKNVSNVCV-PQQVTIGKP-VSWISCGYYHSAFVTTDGELYVFGE--PENGKLGLP 225
Query: 191 GQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAF 250
Q L T + S + K + V G +H+ LT+ VY +G + GQL
Sbjct: 226 NQLLGNHRTPQLVSEIP----EKVIQVACGGEHTVVLTE-NAVYTFGLGQFGQLGLGTFL 280
Query: 251 LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETY 304
+ +++ ++ I G H T+ G M+T+G +G+LG LE +
Sbjct: 281 FETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENF 334
Score = 108 bits (271), Expect = 8e-24
Identities = 112/403 (27%), Positives = 163/403 (40%), Gaps = 54/403 (13%)
Query: 3 REPSASEAAPAAAALFAWGANSYGQLGLGH---KEDVLLPQQLNDFCKPRSVRRITGGGG 59
REP E P + A+F +G + + + G K DV + ++ G
Sbjct: 2 REPE--ELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPV--------------HLSCGDE 45
Query: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
HSAVVT L++ G N GQLGLG I T K+L ++ ACG + T++ TE
Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
Query: 120 GQVLSCGSNSFGQLGVPHGPRRCVVPQ-AIELHKEKVVCIAAGLRHAVAATASGIVFQWG 178
G V + G N+ GQLG+ R + + K+ ++AG + A T G +F WG
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
Query: 179 -TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWG 237
G + +P T +P + G HSA +T GE+YV+G
Sbjct: 166 DNSEGQIGLKNVSNVCVPQQVTIGKP----------VSWISCGYYHSAFVTTDGELYVFG 215
Query: 238 SNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQL 297
++G+L L + + EKV + G H V TE ++T+G +GQL
Sbjct: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQL 274
Query: 298 GRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGAT--EVSCGSEHNLAIIG-GVCY 354
G +E S P + T +SCG H I G+ Y
Sbjct: 275 GLGTFLFE-----------------TSEPKVIENIRDQTISYISCGENHTALITDIGLMY 317
Query: 355 SWGWNEHGMCGDGTE--ANVWAPKPVQALLSSSGLLVGCGAGH 395
++G HG G G E N + P L LV CG H
Sbjct: 318 TFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
Score = 89.4 bits (220), Expect = 6e-18
Identities = 78/309 (25%), Positives = 138/309 (44%), Gaps = 47/309 (15%)
Query: 106 VACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVV-PQAIE-LHKEKVVCIAAGLR 163
++CG + + ++T N ++ GSN++GQLG+ G + + P ++ L EKV A G
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGL--GSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 164 HAVAATASGIVFQWG------TGLASCGRRLCPGQTLPL--FFTAKEPSRVTGLENSKAM 215
H + +T G V+ G GL R T + FFT++ K
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEER----NTFHVISFFTSEH----------KIK 143
Query: 216 CVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAAFLPVPQKIEAHCFQNEKVTAIWSGW 274
+ AGS+ SA+LT+ G +++WG N GQ+ + + VPQ++ + V+ I G+
Sbjct: 144 QLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI----GKPVSWISCGY 199
Query: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
H T G+++ +G + G+LG + L R P + P +
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLP------------NQLLGNHRTPQLVSEIPEKVI- 246
Query: 335 ATEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEA-NVWAPKPVQALLSSSGLLVGCGA 393
+V+CG EH + + Y++G + G G GT PK ++ + + + CG
Sbjct: 247 --QVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGE 304
Query: 394 GHSLALCQL 402
H+ + +
Sbjct: 305 NHTALITDI 313
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 119 bits (298), Expect = 6e-27
Identities = 89/294 (30%), Positives = 144/294 (48%), Gaps = 21/294 (7%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
L+ +G+N++GQLGLG K + P + KP V+ G H+ V T+GG+++ G N
Sbjct: 56 LYMFGSNNWGQLGLGSKSAISKPTCVKAL-KPEKVKLAACGRNHTLVSTEGGNVYATGGN 114
Query: 77 KDGQLGLGHTED------IPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSF 130
+GQLGLG TE+ I +FT I+Q++ G + + LTE+G++ G NS
Sbjct: 115 NEGQLGLGDTEERNTFHVISFFTSEHK-----IKQLSAGSNTSAALTEDGRLFMWGDNSE 169
Query: 131 GQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCP 190
GQ+G+ + CV PQ + + K V I+ G H+ T G ++ +G G+ P
Sbjct: 170 GQIGLKNVSNVCV-PQQVTIGKP-VSWISCGYYHSAFVTTDGELYVFGE--PENGKLGLP 225
Query: 191 GQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAF 250
Q L T + S + K + V G +H+ LT+ VY +G + GQL
Sbjct: 226 NQLLGNHRTPQLVSEIP----EKVIQVACGGEHTVVLTE-NAVYTFGLGQFGQLGLGTFL 280
Query: 251 LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETY 304
+ +++ ++ I G H T+ G M+T+G +G+LG LE +
Sbjct: 281 FETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENF 334
Score = 108 bits (271), Expect = 8e-24
Identities = 112/403 (27%), Positives = 163/403 (40%), Gaps = 54/403 (13%)
Query: 3 REPSASEAAPAAAALFAWGANSYGQLGLGH---KEDVLLPQQLNDFCKPRSVRRITGGGG 59
REP E P + A+F +G + + + G K DV + ++ G
Sbjct: 2 REPE--ELMPDSGAVFTFGKSKFAENNPGKFWFKNDVPV--------------HLSCGDE 45
Query: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
HSAVVT L++ G N GQLGLG I T K+L ++ ACG + T++ TE
Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVSTEG 105
Query: 120 GQVLSCGSNSFGQLGVPHGPRRCVVPQ-AIELHKEKVVCIAAGLRHAVAATASGIVFQWG 178
G V + G N+ GQLG+ R + + K+ ++AG + A T G +F WG
Sbjct: 106 GNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWG 165
Query: 179 -TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWG 237
G + +P T +P + G HSA +T GE+YV+G
Sbjct: 166 DNSEGQIGLKNVSNVCVPQQVTIGKP----------VSWISCGYYHSAFVTTDGELYVFG 215
Query: 238 SNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQL 297
++G+L L + + EKV + G H V TE ++T+G +GQL
Sbjct: 216 EPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENA-VYTFGLGQFGQL 274
Query: 298 GRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGAT--EVSCGSEHNLAIIG-GVCY 354
G +E S P + T +SCG H I G+ Y
Sbjct: 275 GLGTFLFE-----------------TSEPKVIENIRDQTISYISCGENHTALITDIGLMY 317
Query: 355 SWGWNEHGMCGDGTE--ANVWAPKPVQALLSSSGLLVGCGAGH 395
++G HG G G E N + P L LV CG H
Sbjct: 318 TFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
Score = 89.4 bits (220), Expect = 6e-18
Identities = 78/309 (25%), Positives = 138/309 (44%), Gaps = 47/309 (15%)
Query: 106 VACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVV-PQAIE-LHKEKVVCIAAGLR 163
++CG + + ++T N ++ GSN++GQLG+ G + + P ++ L EKV A G
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGL--GSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 164 HAVAATASGIVFQWG------TGLASCGRRLCPGQTLPL--FFTAKEPSRVTGLENSKAM 215
H + +T G V+ G GL R T + FFT++ K
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEER----NTFHVISFFTSEH----------KIK 143
Query: 216 CVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAAFLPVPQKIEAHCFQNEKVTAIWSGW 274
+ AGS+ SA+LT+ G +++WG N GQ+ + + VPQ++ + V+ I G+
Sbjct: 144 QLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTI----GKPVSWISCGY 199
Query: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
H T G+++ +G + G+LG + L R P + P +
Sbjct: 200 YHSAFVTTDGELYVFGEPENGKLGLP------------NQLLGNHRTPQLVSEIPEKVI- 246
Query: 335 ATEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEA-NVWAPKPVQALLSSSGLLVGCGA 393
+V+CG EH + + Y++G + G G GT PK ++ + + + CG
Sbjct: 247 --QVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGE 304
Query: 394 GHSLALCQL 402
H+ + +
Sbjct: 305 NHTALITDI 313
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 105 bits (261), Expect = 1e-22
Identities = 87/276 (31%), Positives = 136/276 (49%), Gaps = 16/276 (5%)
Query: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
G NS GQLG + LP+ + + V ++ G HS V G +F G +GQ
Sbjct: 48 GDNSRGQLGRRGAQRGELPEPIQAL-ETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQ 106
Query: 81 LGLGHTEDIPYFTPCK--SLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHG 138
LG+G ++I FTP K +L I QV+CG ++ L+++ QV S G NS GQLG+
Sbjct: 107 LGIGEFKEIS-FTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKE 165
Query: 139 PRRCVVPQAI-ELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLF 197
PQ + L + +AAG H+ A + G F WG+ S G+ G+ +P+
Sbjct: 166 FPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSN--SAGQLALSGRNVPV- 222
Query: 198 FTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKI 257
+ +P V L+N + + G H+A LT G+V+ +G N+ GQL + P P+K
Sbjct: 223 -QSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQL----GYSPTPEKR 277
Query: 258 EAHCFQ--NEKVTAIWSGWTHLVAQTE-TGKMFTWG 290
+ + V+ I G H +A TG++ ++G
Sbjct: 278 GPQLVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFG 313
Score = 102 bits (255), Expect = 6e-22
Identities = 86/303 (28%), Positives = 133/303 (43%), Gaps = 27/303 (8%)
Query: 100 GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVV-CI 158
G + Q A G +++L N +VLSCG NS GQLG G +R +P+ I+ + +V +
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLG-RRGAQRGELPEPIQALETLIVDLV 80
Query: 159 AAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVL 218
+ G H++A G VF WG G +L G+ + FT P ++ L + K + V
Sbjct: 81 SCGKEHSLAVCHKGRVFAWGAGSEG---QLGIGEFKEISFT---PKKIMTLNDIKIIQVS 134
Query: 219 AGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLV 278
G HS +L+ +V+ WG N HGQL F + + + +G H
Sbjct: 135 CGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSF 194
Query: 279 AQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEV 338
A + G F WG GQL G + Q S P S+ + + G +
Sbjct: 195 ALSLCGTSFGWGSNSAGQL-----ALSGRNVPVQ------SNKPLSVGALKN--LGVVYI 241
Query: 339 SCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLL--VGCGAGH 395
SCG H + G +++G N G G P+ V+ + GL+ + CG+ H
Sbjct: 242 SCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERI---DGLVSQIDCGSYH 298
Query: 396 SLA 398
+LA
Sbjct: 299 TLA 301
Score = 101 bits (251), Expect = 2e-21
Identities = 83/297 (27%), Positives = 127/297 (42%), Gaps = 28/297 (9%)
Query: 57 GGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIML 116
G HS ++ + CG N GQLG + P ++L + V+CG + ++ +
Sbjct: 31 GERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLAV 90
Query: 117 TENGQVLSCGSNSFGQLGVPHGPRRCVVPQAI-ELHKEKVVCIAAGLRHAVAATASGIVF 175
G+V + G+ S GQLG+ P+ I L+ K++ ++ G H++A + VF
Sbjct: 91 CHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVF 150
Query: 176 QWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYV 235
WG + +L G+ P + P RV LE V AG HS +L+ G +
Sbjct: 151 SWG---KNSHGQLGLGKEFP---SQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFG 204
Query: 236 WGSNKHGQLANEAAFLPVP--QKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRAD 293
WGSN GQLA +PV + + +N V I G H T+ GK+FT+G
Sbjct: 205 WGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNR 264
Query: 294 YGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG-ATEVSCGSEHNLAII 349
GQLG P P + G +++ CGS H LA +
Sbjct: 265 SGQLGYS------------------PTPEKRGPQLVERIDGLVSQIDCGSYHTLAYV 303
Score = 70.5 bits (171), Expect = 3e-12
Identities = 61/171 (35%), Positives = 84/171 (49%), Gaps = 14/171 (8%)
Query: 17 LFAWGANSYGQLGLGH-KEDVLLPQQ---LNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72
+FAWGA S GQLG+G KE P++ LND + +++ G HS ++ +F
Sbjct: 96 VFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDI----KIIQVSCGHYHSLALSKDSQVFS 151
Query: 73 CGLNKDGQLGLGHTEDIPYFTP--CKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSF 130
G N GQLGLG E +P +SL G P+ QVA G + L+ G GSNS
Sbjct: 152 WGKNSHGQLGLGK-EFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSA 210
Query: 131 GQLGVP--HGPRRCVVPQAI-ELHKEKVVCIAAGLRHAVAATASGIVFQWG 178
GQL + + P + P ++ L VV I+ G H T G VF +G
Sbjct: 211 GQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFG 261
Score = 59.7 bits (143), Expect = 5e-09
Identities = 56/198 (28%), Positives = 79/198 (39%), Gaps = 20/198 (10%)
Query: 205 RVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFL-PVPQKIEAHCFQ 263
R G ++ + +G HS L V G N GQL A +P+ I+A +
Sbjct: 16 RTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQA--LE 73
Query: 264 NEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPN 323
V + G H +A G++F WG GQLG F S P
Sbjct: 74 TLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLG-------------IGEFKEISFTPK 120
Query: 324 SMPSSPHCLTGATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTE-ANVWAPKPVQAL 381
+ + +VSCG H+LA+ +SWG N HG G G E + +P+ V++L
Sbjct: 121 KIMTLND--IKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSL 178
Query: 382 LSSSGLLVGCGAGHSLAL 399
V G HS AL
Sbjct: 179 EGIPLAQVAAGGAHSFAL 196
Score = 52.8 bits (125), Expect = 7e-07
Identities = 58/196 (29%), Positives = 80/196 (40%), Gaps = 39/196 (19%)
Query: 18 FAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRR--------ITGGGGHSAVVTDGGD 69
F WG+NS GQL L + +P Q N KP SV I+ G H+AV+T G
Sbjct: 203 FGWGSNSAGQLALSGRN---VPVQSN---KPLSVGALKNLGVVYISCGDAHTAVLTQDGK 256
Query: 70 LFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTE-NGQVLSCGSN 128
+F G N+ GQLG T + + + G + Q+ CG T+ GQV+S G
Sbjct: 257 VFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAYVHTTGQVVSFG-- 313
Query: 129 SFGQLGVPHGPRRCVVPQAIELHKEK--VVCIAAG-------LRHAVAATASGIVFQWGT 179
HGP P E E + C+ + ++H A T + V T
Sbjct: 314 --------HGPSDTSKPTHPEALTENFDISCLISAEDFVDVQVKHIFAGTYANFV----T 361
Query: 180 GLASCGRRLCPGQTLP 195
PG+TLP
Sbjct: 362 THQDTSSTRAPGKTLP 377
Score = 35.0 bits (79), Expect = 0.14
Identities = 22/65 (33%), Positives = 31/65 (47%), Gaps = 1/65 (1%)
Query: 337 EVSCGSEHNLAIIGGV-CYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGH 395
+ + G H+L ++ S G N G G P+P+QAL + LV CG H
Sbjct: 27 QAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEH 86
Query: 396 SLALC 400
SLA+C
Sbjct: 87 SLAVC 91
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 104 bits (259), Expect = 2e-22
Identities = 80/252 (31%), Positives = 122/252 (48%), Gaps = 18/252 (7%)
Query: 54 ITGGGGHSAVVTDGGD-LFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDF 112
+ G G+ + T D +FV G N G LGLG + SL G I ++ G
Sbjct: 50 VFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGP 109
Query: 113 TIML-TENGQVLSCGSNSFGQLG---VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAA 168
I+L T G+V + G N++ QLG HG C + + L ++V+ +A G H++
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHI--STNLSNKQVIEVACGSYHSLVL 167
Query: 169 TASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTG-LENSKAMCVLAGSDHSASL 227
T+ G VF WG + ++ G T+ P RVTG L+N + + G ++
Sbjct: 168 TSDGEVFAWGYNNSG---QVGSGSTV----NQPIPRRVTGCLQNKVVVTIACGQMCCMAV 220
Query: 228 TDAGEVYVWGSNKHGQLA-NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKM 286
D GEVYVWG N +GQL + P P ++ A Q +V + G+ H + T+ G++
Sbjct: 221 VDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAA--LQGIRVQRVACGYAHTLVLTDEGQV 278
Query: 287 FTWGRADYGQLG 298
+ WG YGQLG
Sbjct: 279 YAWGANSYGQLG 290
Score = 103 bits (258), Expect = 2e-22
Identities = 84/289 (29%), Positives = 130/289 (44%), Gaps = 33/289 (11%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
+F G N G LGLG + + P++L+ + G G H + T G++F G N
Sbjct: 67 IFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHN 126
Query: 77 KDGQLGLGHTEDIPYFTPC---KSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQL 133
QLG G T PC +L + +VACG +++LT +G+V + G N+ GQ+
Sbjct: 127 AYSQLGNGTTNH--GLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQV 184
Query: 134 GVPHGPRRCVVPQAIE--LHKEKVVCIAAGLRHAVAATASGIVFQWG------TGLASCG 185
G + +P+ + L + VV IA G +A +G V+ WG GL + G
Sbjct: 185 GSGSTVNQ-PIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSG 243
Query: 186 RRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA 245
+ P RV L+ + V G H+ LTD G+VY WG+N +GQL
Sbjct: 244 NQ-------------PTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Query: 246 ---NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGR 291
P P +E + ++ A S T A+T+ G ++ WG+
Sbjct: 291 TGNKSNQSYPTPVTVEKD--RIIEIAACHSTHTS-AAKTQGGHVYMWGQ 336
Score = 101 bits (251), Expect = 2e-21
Identities = 82/293 (27%), Positives = 125/293 (42%), Gaps = 42/293 (14%)
Query: 117 TENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLR-HAVAATASGIV 174
T N ++ G+N G LG+ + + P+ ++ L+ +K+ C++ G H V AT G V
Sbjct: 62 TVNDEIFVLGTNCCGCLGLGD-VQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEV 120
Query: 175 FQWG-TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEV 233
F WG + G +P + T L N + + V GS HS LT GEV
Sbjct: 121 FTWGHNAYSQLGNGTTNHGLVPCHIS-------TNLSNKQVIEVACGSYHSLVLTSDGEV 173
Query: 234 YVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRA 292
+ WG N GQ+ + + P+P+++ C QN+ V I G +A +TG+++ WG
Sbjct: 174 FAWGYNNSGQVGSGSTVNQPIPRRVTG-CLQNKVVVTIACGQMCCMAVVDTGEVYVWGYN 232
Query: 293 DYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATE------VSCGSEHNL 346
GQLG NS C A + V+CG H L
Sbjct: 233 GNGQLGLG----------------------NSGNQPTPCRVAALQGIRVQRVACGYAHTL 270
Query: 347 AIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLA 398
+ G Y+WG N +G G G ++N P PV + C + H+ A
Sbjct: 271 VLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSA 323
Score = 90.1 bits (222), Expect = 4e-18
Identities = 70/247 (28%), Positives = 106/247 (42%), Gaps = 20/247 (8%)
Query: 11 APAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDL 70
A +F WG N+Y QLG G L+P ++ + V + G HS V+T G++
Sbjct: 114 ATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEV 173
Query: 71 FVCGLNKDGQLGLGHTEDIPYFTPCKSLFGC----PIQQVACGWDFTIMLTENGQVLSCG 126
F G N GQ+G G T + P + + GC + +ACG + + + G+V G
Sbjct: 174 FAWGYNNSGQVGSGSTVNQPI---PRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWG 230
Query: 127 SNSFGQLGVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWG-TGLASCG 185
N GQLG+ + + + L +V +A G H + T G V+ WG G
Sbjct: 231 YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLG 290
Query: 186 RRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA 245
Q+ P T E R+ + A C + SA+ T G VY+W GQ
Sbjct: 291 TGNKSNQSYPTPVTV-EKDRIIEI----AAC--HSTHTSAAKTQGGHVYMW-----GQCR 338
Query: 246 NEAAFLP 252
++ LP
Sbjct: 339 GQSVILP 345
Score = 74.3 bits (181), Expect = 2e-13
Identities = 70/257 (27%), Positives = 103/257 (40%), Gaps = 27/257 (10%)
Query: 146 QAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSR 205
+ ++L ++ V +AG + T + +F GT C L G EP R
Sbjct: 40 EELQLIRQACVFGSAG-NEVLYTTVNDEIFVLGTNCCGC---LGLGDVQSTI----EPRR 91
Query: 206 VTGLENSKAMCVLAGSD-HSASLTDAGEVYVWGSNKHGQLANEAAFLP-VPQKIEAHCFQ 263
+ L K C+ GS H T GEV+ WG N + QL N VP I +
Sbjct: 92 LDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTN-LS 150
Query: 264 NEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPN 323
N++V + G H + T G++F WG + GQ+G + P R
Sbjct: 151 NKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQ-----------PIPRRVT 199
Query: 324 SMPSSPHCLTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALL 382
+ +T ++CG +A++ G Y WG+N +G G G N P V AL
Sbjct: 200 GCLQNKVVVT----IACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQ 255
Query: 383 SSSGLLVGCGAGHSLAL 399
V CG H+L L
Sbjct: 256 GIRVQRVACGYAHTLVL 272
Score = 62.0 bits (149), Expect = 1e-09
Identities = 50/203 (24%), Positives = 85/203 (41%), Gaps = 26/203 (12%)
Query: 195 PLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAG-EVYVWGSNKHGQLA-NEAAFLP 252
P+F E L+ + CV + + T E++V G+N G L +
Sbjct: 32 PIFSLCSEEE----LQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI 87
Query: 253 VPQKIEAHCFQNEKVTAI-WSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEK 311
P+++++ +K+ + + H+V T G++FTWG Y QLG +
Sbjct: 88 EPRRLDS--LNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNH------- 138
Query: 312 QDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEA 370
+PC N EV+CGS H+L + G ++WG+N G G G+
Sbjct: 139 --GLVPCHISTNLSNKQ------VIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTV 190
Query: 371 NVWAPKPVQALLSSSGLL-VGCG 392
N P+ V L + ++ + CG
Sbjct: 191 NQPIPRRVTGCLQNKVVVTIACG 213
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 103 bits (256), Expect = 4e-22
Identities = 87/298 (29%), Positives = 136/298 (45%), Gaps = 27/298 (9%)
Query: 6 SASEAAPAAA--ALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAV 63
SASEA +F +G N LG G + L+P++L C + G G H +
Sbjct: 30 SASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLL 89
Query: 64 VTDGGDLFVCGLNKDGQLGLGHT-EDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQV 122
T+ G ++ G N QLG G T + I C +L + +VACG ++ L +G+V
Sbjct: 90 STEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEV 149
Query: 123 LSCGSNSFGQLGVPHGPRRCVVPQAIE--LHKEKVVCIAAGLRHAVAATASGIVFQWG-- 178
+ G N+ GQ+G + P+ + LH ++VV IA G ++A +G V+ WG
Sbjct: 150 FAWGYNNCGQVGSGSTANQ-PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208
Query: 179 ----TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVY 234
GL + G +L P RV L + ++ G H+ +LTD G +Y
Sbjct: 209 GNGQLGLGNNGNQL-------------TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLY 255
Query: 235 VWGSNKHGQL-ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGR 291
WG+N +GQL L P I + ++ A S T A+T+ G ++ WG+
Sbjct: 256 AWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTS-AAKTQGGHVYMWGQ 312
Score = 94.7 bits (234), Expect = 2e-19
Identities = 91/308 (29%), Positives = 130/308 (42%), Gaps = 47/308 (15%)
Query: 64 VTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIML-TENGQV 122
VTD ++FV GLN LG G + + L G I+ ++ G ++L TE+G V
Sbjct: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
Query: 123 LSCGSNSFGQLGVPHGPRR---CVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGT 179
+ G N + QLG +G V L ++VV +A G H++A A G VF WG
Sbjct: 97 YAWGHNGYSQLG--NGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGY 154
Query: 180 GLASCGRRLCPGQTLPLFFTAKEPSRVTG-LENSKAMCVLAGSDHSASLTDAGEVYVWGS 238
+CG+ + G T P +VT L + + + G S ++ D GEVY WG
Sbjct: 155 N--NCGQ-VGSGSTA----NQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207
Query: 239 NKHGQLA---NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYG 295
N +GQL N PV + V I G+ H +A T+ G ++ WG YG
Sbjct: 208 NGNGQLGLGNNGNQLTPV----RVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYG 263
Query: 296 QLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEV----SCGSEHNLA--II 349
QLG + N++ S H + V +C S H A
Sbjct: 264 QLG--------------------TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQ 303
Query: 350 GGVCYSWG 357
GG Y WG
Sbjct: 304 GGHVYMWG 311
Score = 92.0 bits (227), Expect = 1e-18
Identities = 73/245 (29%), Positives = 107/245 (43%), Gaps = 28/245 (11%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
++AWG N Y QLG G + P Q+ + V + G HS + G++F G N
Sbjct: 96 VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYN 155
Query: 77 KDGQLGLGHTEDIPYFTPCKSLFGCPIQQV---ACGWDFTIMLTENGQVLSCGSNSFGQL 133
GQ+G G T + P TP K I++V ACG ++ + +NG+V G N GQL
Sbjct: 156 NCGQVGSGSTANQP--TPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQL 213
Query: 134 GVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGT------GLASCGRR 187
G+ + + + LH V I G H +A T G+++ WG G +
Sbjct: 214 GLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNL 273
Query: 188 LCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANE 247
L P + E RV + A C A + SA+ T G VY+W GQ +
Sbjct: 274 LSPAHIM------VEKERVVEI----AACHSAHT--SAAKTQGGHVYMW-----GQCRGQ 316
Query: 248 AAFLP 252
+ LP
Sbjct: 317 SVILP 321
Score = 87.8 bits (216), Expect = 2e-17
Identities = 77/290 (26%), Positives = 128/290 (44%), Gaps = 30/290 (10%)
Query: 114 IMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLR-HAVAATAS 171
+ +T+N +V G N LG + +VP+ +E L +K+ ++ G H + +T
Sbjct: 35 LYVTDNDEVFVFGLNYSNCLGTGDN-QSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTED 93
Query: 172 GIVFQWG-TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDA 230
G+V+ WG G + G P+ T L + + V GS HS +L
Sbjct: 94 GVVYAWGHNGYSQLGNGTTNQGIAPV-------QVCTNLLIKQVVEVACGSHHSMALAAD 146
Query: 231 GEVYVWGSNKHGQL-ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTW 289
GEV+ WG N GQ+ + A P P+K+ +C ++V I G T +A + G+++ W
Sbjct: 147 GEVFAWGYNNCGQVGSGSTANQPTPRKV-TNCLHIKRVVGIACGQTSSMAVLDNGEVYGW 205
Query: 290 GRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII 349
G GQLG L + L R ++ H + ++ CG H LA+
Sbjct: 206 GYNGNGQLG----------LGNNGNQLTPVR-----VAALHSVC-VNQIVCGYAHTLALT 249
Query: 350 G-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLA 398
G+ Y+WG N +G G G + N+ +P + + C + H+ A
Sbjct: 250 DEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSA 299
Score = 70.1 bits (170), Expect = 4e-12
Identities = 55/200 (27%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 203 PSRVTGLENSKAMCVLAGSD-HSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHC 261
P ++ GL K + GS H T+ G VY WG N + QL N +
Sbjct: 65 PKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTN 124
Query: 262 FQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRP 321
++V + G H +A G++F WG + GQ+G S ++P
Sbjct: 125 LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVG---------------SGSTANQP 169
Query: 322 -PNSMPSSPHCLTGATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQ 379
P + + H + ++CG ++A++ G Y WG+N +G G G N P V
Sbjct: 170 TPRKVTNCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVA 228
Query: 380 ALLSSSGLLVGCGAGHSLAL 399
AL S + CG H+LAL
Sbjct: 229 ALHSVCVNQIVCGYAHTLAL 248
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 96.7 bits (239), Expect = 4e-20
Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%)
Query: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
G GQLGLG E+V+ ++ P V + GG H+ ++ G ++ G N +G
Sbjct: 58 GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 115
Query: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138
LG + + P K + QV+ G T LT++G+V GS ++ G +G+
Sbjct: 116 LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 175
Query: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198
++ +VP ++L VV +A+G H V TA G ++ G CG + G+ LF
Sbjct: 176 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 228
Query: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241
A R GLE CV+ G+ + +++ G VY +G + +
Sbjct: 229 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 286
Query: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294
QL E+ F +PQ + + F+N T W G++ H V GK ++ GRA+Y
Sbjct: 287 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 340
Query: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
G+LG L S+P+ L + V+CG+ A+ G
Sbjct: 341 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 383
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399
++WG + G G + + W+P + + L + L V G H++ L
Sbjct: 384 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 431
Score = 68.9 bits (167), Expect = 9e-12
Identities = 93/368 (25%), Positives = 145/368 (39%), Gaps = 44/368 (11%)
Query: 52 RRITGGGG----HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVA 107
RR+ G H + T+ G + G GQLGLG + P + Q
Sbjct: 32 RRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQAE 90
Query: 108 CGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRHAV 166
G T+ L+++GQV S G N G LG +VP +EL +EKVV ++AG H
Sbjct: 91 AGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSHTA 149
Query: 167 AATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSAS 226
A T G VF WG+ + G G P+ K V + + V +G+DH
Sbjct: 150 ALTDDGRVFLWGSFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHLVM 203
Query: 227 LTDAGEVYVWGSNKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTAIW 271
LT G++Y G + GQL AN + + + C + + +
Sbjct: 204 LTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAF 263
Query: 272 SGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHC 331
G A + G ++ +G ++Y QLG + F+ P ++ S +
Sbjct: 264 CGAYFTFAISHEGHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFKNS 309
Query: 332 LTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGLLV 389
S G H + + G YS G E+G G G A + P + L + S +
Sbjct: 310 TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVAC 369
Query: 390 GCGAGHSL 397
G G+++
Sbjct: 370 GASVGYAV 377
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
++ +G ++Y QLG E +PQ L F +S +GG H+ + G + G
Sbjct: 278 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 337
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
+ G+LGLG + S + VACG +T++G+V + G + QLG
Sbjct: 338 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 396
Query: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166
V +L V+ +++G +H V
Sbjct: 397 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 429
Score = 34.7 bits (78), Expect = 0.19
Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%)
Query: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
+H TE G + T G+ D GQLG E R ++ S P
Sbjct: 43 SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 85
Query: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393
+ G H + + G YS+G N+ G G T P + L + V G
Sbjct: 86 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 145
Query: 394 GHSLAL 399
H+ AL
Sbjct: 146 SHTAAL 151
Score = 32.3 bits (72), Expect = 0.92
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)
Query: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64
S A +FAWG + QLG G ED P + + + R V ++ GG H+ ++
Sbjct: 372 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 431
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 96.7 bits (239), Expect = 4e-20
Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%)
Query: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
G GQLGLG E+V+ ++ P V + GG H+ ++ G ++ G N +G
Sbjct: 72 GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 129
Query: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138
LG + + P K + QV+ G T LT++G+V GS ++ G +G+
Sbjct: 130 LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 189
Query: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198
++ +VP ++L VV +A+G H V TA G ++ G CG + G+ LF
Sbjct: 190 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 242
Query: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241
A R GLE CV+ G+ + +++ G VY +G + +
Sbjct: 243 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 300
Query: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294
QL E+ F +PQ + + F+N T W G++ H V GK ++ GRA+Y
Sbjct: 301 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 354
Query: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
G+LG L S+P+ L + V+CG+ A+ G
Sbjct: 355 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 397
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399
++WG + G G + + W+P + + L + L V G H++ L
Sbjct: 398 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 445
Score = 70.1 bits (170), Expect = 4e-12
Identities = 93/370 (25%), Positives = 145/370 (39%), Gaps = 40/370 (10%)
Query: 46 CKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQ 105
C P + T H + T+ G + G GQLGLG + P + Q
Sbjct: 44 CGPSPPDQKTRPVSHRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQ 102
Query: 106 VACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRH 164
G T+ L+++GQV S G N G LG +VP +EL +EKVV ++AG H
Sbjct: 103 AEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSH 161
Query: 165 AVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHS 224
A T G VF WG+ + G G P+ K V + + V +G+DH
Sbjct: 162 TAALTDDGRVFLWGSFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHL 215
Query: 225 ASLTDAGEVYVWGSNKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTA 269
LT G++Y G + GQL AN + + + C + +
Sbjct: 216 VMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQD 275
Query: 270 IWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSP 329
+ G A + G ++ +G ++Y QLG + F+ P ++ S
Sbjct: 276 AFCGAYFTFAISHEGHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFK 321
Query: 330 HCLTGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGL 387
+ S G H + + G YS G E+G G G A + P + L + S +
Sbjct: 322 NSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSV 381
Query: 388 LVGCGAGHSL 397
G G+++
Sbjct: 382 ACGASVGYAV 391
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
++ +G ++Y QLG E +PQ L F +S +GG H+ + G + G
Sbjct: 292 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 351
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
+ G+LGLG + S + VACG +T++G+V + G + QLG
Sbjct: 352 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 410
Query: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166
V +L V+ +++G +H V
Sbjct: 411 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 443
Score = 34.7 bits (78), Expect = 0.19
Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%)
Query: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
+H TE G + T G+ D GQLG E R ++ S P
Sbjct: 57 SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 99
Query: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393
+ G H + + G YS+G N+ G G T P + L + V G
Sbjct: 100 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 159
Query: 394 GHSLAL 399
H+ AL
Sbjct: 160 SHTAAL 165
Score = 32.3 bits (72), Expect = 0.92
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)
Query: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64
S A +FAWG + QLG G ED P + + + R V ++ GG H+ ++
Sbjct: 386 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 445
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 96.7 bits (239), Expect = 4e-20
Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%)
Query: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
G GQLGLG E+V+ ++ P V + GG H+ ++ G ++ G N +G
Sbjct: 41 GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 98
Query: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138
LG + + P K + QV+ G T LT++G+V GS ++ G +G+
Sbjct: 99 LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 158
Query: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198
++ +VP ++L VV +A+G H V TA G ++ G CG + G+ LF
Sbjct: 159 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 211
Query: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241
A R GLE CV+ G+ + +++ G VY +G + +
Sbjct: 212 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
Query: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294
QL E+ F +PQ + + F+N T W G++ H V GK ++ GRA+Y
Sbjct: 270 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 323
Query: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
G+LG L S+P+ L + V+CG+ A+ G
Sbjct: 324 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 366
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399
++WG + G G + + W+P + + L + L V G H++ L
Sbjct: 367 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/356 (25%), Positives = 141/356 (39%), Gaps = 40/356 (11%)
Query: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
H + T+ G + G GQLGLG + P + Q G T+ L+++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQAEAGGMHTVCLSKS 85
Query: 120 GQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWG 178
GQV S G N G LG +VP +EL +EKVV ++AG H A T G VF WG
Sbjct: 86 GQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 179 TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238
+ + G G P+ K V + + V +G+DH LT G++Y G
Sbjct: 145 SFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGC 198
Query: 239 NKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTAIWSGWTHLVAQTET 283
+ GQL AN + + + C + + + G A +
Sbjct: 199 GEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHE 258
Query: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSE 343
G ++ +G ++Y QLG + F+ P ++ S + S G
Sbjct: 259 GHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFKNSTKSWVGFSGGQH 304
Query: 344 HNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGLLVGCGAGHSL 397
H + + G YS G E+G G G A + P + L + S + G G+++
Sbjct: 305 HTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
++ +G ++Y QLG E +PQ L F +S +GG H+ + G + G
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
+ G+LGLG + S + VACG +T++G+V + G + QLG
Sbjct: 321 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 379
Query: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166
V +L V+ +++G +H V
Sbjct: 380 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
Score = 34.7 bits (78), Expect = 0.19
Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%)
Query: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
+H TE G + T G+ D GQLG E R ++ S P
Sbjct: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 68
Query: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393
+ G H + + G YS+G N+ G G T P + L + V G
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 128
Query: 394 GHSLAL 399
H+ AL
Sbjct: 129 SHTAAL 134
Score = 32.3 bits (72), Expect = 0.92
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)
Query: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64
S A +FAWG + QLG G ED P + + + R V ++ GG H+ ++
Sbjct: 355 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 96.7 bits (239), Expect = 4e-20
Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%)
Query: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
G GQLGLG E+V+ ++ P V + GG H+ ++ G ++ G N +G
Sbjct: 41 GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 98
Query: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138
LG + + P K + QV+ G T LT++G+V GS ++ G +G+
Sbjct: 99 LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 158
Query: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198
++ +VP ++L VV +A+G H V TA G ++ G CG + G+ LF
Sbjct: 159 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 211
Query: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241
A R GLE CV+ G+ + +++ G VY +G + +
Sbjct: 212 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
Query: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294
QL E+ F +PQ + + F+N T W G++ H V GK ++ GRA+Y
Sbjct: 270 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 323
Query: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
G+LG L S+P+ L + V+CG+ A+ G
Sbjct: 324 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 366
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399
++WG + G G + + W+P + + L + L V G H++ L
Sbjct: 367 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/356 (25%), Positives = 141/356 (39%), Gaps = 40/356 (11%)
Query: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
H + T+ G + G GQLGLG + P + Q G T+ L+++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQAEAGGMHTVCLSKS 85
Query: 120 GQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWG 178
GQV S G N G LG +VP +EL +EKVV ++AG H A T G VF WG
Sbjct: 86 GQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 179 TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238
+ + G G P+ K V + + V +G+DH LT G++Y G
Sbjct: 145 SFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGC 198
Query: 239 NKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTAIWSGWTHLVAQTET 283
+ GQL AN + + + C + + + G A +
Sbjct: 199 GEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHE 258
Query: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSE 343
G ++ +G ++Y QLG + F+ P ++ S + S G
Sbjct: 259 GHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFKNSTKSWVGFSGGQH 304
Query: 344 HNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGLLVGCGAGHSL 397
H + + G YS G E+G G G A + P + L + S + G G+++
Sbjct: 305 HTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
++ +G ++Y QLG E +PQ L F +S +GG H+ + G + G
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
+ G+LGLG + S + VACG +T++G+V + G + QLG
Sbjct: 321 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 379
Query: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166
V +L V+ +++G +H V
Sbjct: 380 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
Score = 34.7 bits (78), Expect = 0.19
Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%)
Query: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
+H TE G + T G+ D GQLG E R ++ S P
Sbjct: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 68
Query: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393
+ G H + + G YS+G N+ G G T P + L + V G
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 128
Query: 394 GHSLAL 399
H+ AL
Sbjct: 129 SHTAAL 134
Score = 32.3 bits (72), Expect = 0.92
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)
Query: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64
S A +FAWG + QLG G ED P + + + R V ++ GG H+ ++
Sbjct: 355 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 96.7 bits (239), Expect = 4e-20
Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%)
Query: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
G GQLGLG E+V+ ++ P V + GG H+ ++ G ++ G N +G
Sbjct: 41 GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 98
Query: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138
LG + + P K + QV+ G T LT++G+V GS ++ G +G+
Sbjct: 99 LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 158
Query: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198
++ +VP ++L VV +A+G H V TA G ++ G CG + G+ LF
Sbjct: 159 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 211
Query: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241
A R GLE CV+ G+ + +++ G VY +G + +
Sbjct: 212 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
Query: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294
QL E+ F +PQ + + F+N T W G++ H V GK ++ GRA+Y
Sbjct: 270 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 323
Query: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
G+LG L S+P+ L + V+CG+ A+ G
Sbjct: 324 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 366
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399
++WG + G G + + W+P + + L + L V G H++ L
Sbjct: 367 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/356 (25%), Positives = 141/356 (39%), Gaps = 40/356 (11%)
Query: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
H + T+ G + G GQLGLG + P + Q G T+ L+++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQAEAGGMHTVCLSKS 85
Query: 120 GQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWG 178
GQV S G N G LG +VP +EL +EKVV ++AG H A T G VF WG
Sbjct: 86 GQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 179 TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238
+ + G G P+ K V + + V +G+DH LT G++Y G
Sbjct: 145 SFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGC 198
Query: 239 NKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTAIWSGWTHLVAQTET 283
+ GQL AN + + + C + + + G A +
Sbjct: 199 GEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHE 258
Query: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSE 343
G ++ +G ++Y QLG + F+ P ++ S + S G
Sbjct: 259 GHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFKNSTKSWVGFSGGQH 304
Query: 344 HNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGLLVGCGAGHSL 397
H + + G YS G E+G G G A + P + L + S + G G+++
Sbjct: 305 HTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
++ +G ++Y QLG E +PQ L F +S +GG H+ + G + G
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
+ G+LGLG + S + VACG +T++G+V + G + QLG
Sbjct: 321 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 379
Query: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166
V +L V+ +++G +H V
Sbjct: 380 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
Score = 34.7 bits (78), Expect = 0.19
Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%)
Query: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
+H TE G + T G+ D GQLG E R ++ S P
Sbjct: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 68
Query: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393
+ G H + + G YS+G N+ G G T P + L + V G
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 128
Query: 394 GHSLAL 399
H+ AL
Sbjct: 129 SHTAAL 134
Score = 32.3 bits (72), Expect = 0.92
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)
Query: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64
S A +FAWG + QLG G ED P + + + R V ++ GG H+ ++
Sbjct: 355 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 96.7 bits (239), Expect = 4e-20
Identities = 107/408 (26%), Positives = 177/408 (43%), Gaps = 63/408 (15%)
Query: 21 GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQ 80
G GQLGLG E+V+ ++ P V + GG H+ ++ G ++ G N +G
Sbjct: 41 GQGDVGQLGLG--ENVMERKKPALVSIPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGA 98
Query: 81 LGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS--NSFGQLGVPHG 138
LG + + P K + QV+ G T LT++G+V GS ++ G +G+
Sbjct: 99 LGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEP 158
Query: 139 PRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFF 198
++ +VP ++L VV +A+G H V TA G ++ G CG + G+ LF
Sbjct: 159 MKKSMVPVQVQL-DVPVVKVASGNDHLVMLTADGDLYTLG-----CGEQGQLGRVPELF- 211
Query: 199 TAKEPSRVTGLENSKA-MCVL----------------AGSDHSASLTDAGEVYVWGSNKH 241
A R GLE CV+ G+ + +++ G VY +G + +
Sbjct: 212 -ANRGGR-QGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNY 269
Query: 242 GQL---ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWT----HLVAQTETGKMFTWGRADY 294
QL E+ F +PQ + + F+N T W G++ H V GK ++ GRA+Y
Sbjct: 270 HQLGTPGTESCF--IPQNLTS--FKNS--TKSWVGFSGGQHHTVCMDSEGKAYSLGRAEY 323
Query: 295 GQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII-GGVC 353
G+LG L S+P+ L + V+CG+ A+ G
Sbjct: 324 GRLG-----------------LGEGAEEKSIPTLISRLPAVSSVACGASVGYAVTKDGRV 366
Query: 354 YSWGWNEHGMCGDGTEANVWAPKPV--QALLSSSGLLVGCGAGHSLAL 399
++WG + G G + + W+P + + L + L V G H++ L
Sbjct: 367 FAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
Score = 68.6 bits (166), Expect = 1e-11
Identities = 90/356 (25%), Positives = 141/356 (39%), Gaps = 40/356 (11%)
Query: 60 HSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
H + T+ G + G GQLGLG + P + Q G T+ L+++
Sbjct: 27 HRSHSTEPGLVLTLGQGDVGQLGLGENV-MERKKPALVSIPEDVVQAEAGGMHTVCLSKS 85
Query: 120 GQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWG 178
GQV S G N G LG +VP +EL +EKVV ++AG H A T G VF WG
Sbjct: 86 GQVYSFGCNDEGALGRDTSVEGSEMVPGKVEL-QEKVVQVSAGDSHTAALTDDGRVFLWG 144
Query: 179 TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238
+ + G G P+ K V + + V +G+DH LT G++Y G
Sbjct: 145 SFRDNNG---VIGLLEPM---KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGC 198
Query: 239 NKHGQL-------ANEAAFLPVPQKIEAHCFQ--------NEKVTAIWSGWTHLVAQTET 283
+ GQL AN + + + C + + + G A +
Sbjct: 199 GEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHE 258
Query: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSE 343
G ++ +G ++Y QLG + F+ P ++ S + S G
Sbjct: 259 GHVYGFGLSNYHQLGTP---------GTESCFI-----PQNLTSFKNSTKSWVGFSGGQH 304
Query: 344 HNLAIIG-GVCYSWGWNEHGMCGDGTEANVWA-PKPVQALLSSSGLLVGCGAGHSL 397
H + + G YS G E+G G G A + P + L + S + G G+++
Sbjct: 305 HTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSSVACGASVGYAV 360
Score = 47.4 bits (111), Expect = 3e-05
Identities = 39/153 (25%), Positives = 66/153 (43%), Gaps = 4/153 (2%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDF-CKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
++ +G ++Y QLG E +PQ L F +S +GG H+ + G + G
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
+ G+LGLG + S + VACG +T++G+V + G + QLG
Sbjct: 321 AEYGRLGLGEGAEEKSIPTLISRLPA-VSSVACGASVGYAVTKDGRVFAWGMGTNYQLGT 379
Query: 136 PHGPRRC--VVPQAIELHKEKVVCIAAGLRHAV 166
V +L V+ +++G +H V
Sbjct: 380 GQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTV 412
Score = 34.7 bits (78), Expect = 0.19
Identities = 32/126 (25%), Positives = 45/126 (35%), Gaps = 18/126 (14%)
Query: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTG 334
+H TE G + T G+ D GQLG E R ++ S P
Sbjct: 26 SHRSHSTEPGLVLTLGQGDVGQLGLGENVME--------------RKKPALVSIPE---D 68
Query: 335 ATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGA 393
+ G H + + G YS+G N+ G G T P + L + V G
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGD 128
Query: 394 GHSLAL 399
H+ AL
Sbjct: 129 SHTAAL 134
Score = 32.3 bits (72), Expect = 0.92
Identities = 18/60 (30%), Positives = 28/60 (46%), Gaps = 1/60 (1%)
Query: 6 SASEAAPAAAALFAWGANSYGQLGLGHKEDVLLP-QQLNDFCKPRSVRRITGGGGHSAVV 64
S A +FAWG + QLG G ED P + + + R V ++ GG H+ ++
Sbjct: 355 SVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVSSGGQHTVLL 414
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 94.0 bits (232), Expect = 3e-19
Identities = 73/230 (31%), Positives = 115/230 (50%), Gaps = 16/230 (6%)
Query: 8 SEAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDG 67
S A LFAWG N +GQLG+G K Q+ + + +I+ G HS ++
Sbjct: 150 SLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMS 209
Query: 68 GDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGS 127
G+++ G N+ GQLGLGHTE + + L ++ VACG + +LT++G + + G+
Sbjct: 210 GNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGA 269
Query: 128 NSFGQLG---VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATAS-GIVFQWGTG--- 180
GQLG + R C+V EL +V IA G H +A + G VF +G+G
Sbjct: 270 GKHGQLGHNSTQNELRPCLV---AELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDG 326
Query: 181 -LASCGRR--LCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASL 227
L + G R L P LP+ ++ E ++ + K + ++AG + S L
Sbjct: 327 QLGNGGTRDQLMP---LPVKVSSSEELKLESHTSEKELIMIAGGNQSILL 373
Score = 92.4 bits (228), Expect = 7e-19
Identities = 66/198 (33%), Positives = 101/198 (51%), Gaps = 10/198 (5%)
Query: 103 IQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAG 161
I Q+ CG ++ L++ G++ + G N GQLGV PQ +E L + I+AG
Sbjct: 140 IIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAG 199
Query: 162 LRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGS 221
H++A + SG ++ WG CG+ L G T + +PS + GL+N K V G
Sbjct: 200 EAHSMALSMSGNIYSWGKN--ECGQ-LGLGHTE----SKDDPSLIEGLDNQKVEFVACGG 252
Query: 222 DHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSG-WTHLVAQ 280
HSA LT G ++ +G+ KHGQL + + + + A +VT I G W L
Sbjct: 253 SHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAE-LVGYRVTQIACGRWHTLAYV 311
Query: 281 TETGKMFTWGRADYGQLG 298
++ GK+F++G GQLG
Sbjct: 312 SDLGKVFSFGSGKDGQLG 329
Score = 87.4 bits (215), Expect = 2e-17
Identities = 86/304 (28%), Positives = 136/304 (44%), Gaps = 30/304 (9%)
Query: 49 RSVRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTP---CKSLFGCPIQQ 105
+ + +IT G HS ++ GG+LF G N GQLG+G P T + L G P+ Q
Sbjct: 138 KKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVG--RKFPSTTTPQIVEHLAGVPLAQ 195
Query: 106 VACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRH 164
++ G ++ L+ +G + S G N GQLG+ H + P IE L +KV +A G H
Sbjct: 196 ISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESK-DDPSLIEGLDNQKVEFVACGGSH 254
Query: 165 AVAATASGIVFQWGTGL-ASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDH 223
+ T G++F +G G G + P RVT + G H
Sbjct: 255 SALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQ--------IACGRWH 306
Query: 224 S-ASLTDAGEVYVWGSNKHGQLANEAA---FLPVPQKIEAHCFQNEKVTAIWSGWTHLVA 279
+ A ++D G+V+ +GS K GQL N +P+P K+ + + K+ + S ++
Sbjct: 307 TLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSS--EELKLESHTSEKELIMI 364
Query: 280 QTETGKMFTWGRAD--YGQLGRKLETY-EG----WKLEKQDS-FLPCSRPPNSMPSSPHC 331
+ W + + Y L R + T EG W + + + R + SSP C
Sbjct: 365 AGGNQSILLWIKKENSYVNLKRTIPTLNEGTVKRWIADVETKRWQSTKREIQEIFSSPAC 424
Query: 332 LTGA 335
LTG+
Sbjct: 425 LTGS 428
Score = 84.0 bits (206), Expect = 3e-16
Identities = 66/235 (28%), Positives = 105/235 (44%), Gaps = 31/235 (13%)
Query: 150 LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGL 209
L ++K++ I G H++A + G +F WG L +L G+ P T + + G+
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHG---QLGVGRKFPSTTTPQIVEHLAGV 191
Query: 210 ENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA-NEAAFLPVPQKIEAHCFQNEKVT 268
++ + AG HS +L+ +G +Y WG N+ GQL P IE N+KV
Sbjct: 192 PLAQ---ISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG--LDNQKVE 246
Query: 269 AIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSS 328
+ G +H T+ G +FT+G +GQLG Q+ PC
Sbjct: 247 FVACGGSHSALLTQDGLLFTFGAGKHGQLGHN---------STQNELRPCLVAE------ 291
Query: 329 PHCLTG--ATEVSCGSEHNLAIIG--GVCYSWGWNEHGMCGDGTEANVWAPKPVQ 379
L G T+++CG H LA + G +S+G + G G+G + P PV+
Sbjct: 292 ---LVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVK 343
Score = 71.6 bits (174), Expect = 1e-12
Identities = 64/263 (24%), Positives = 106/263 (40%), Gaps = 50/263 (19%)
Query: 145 PQAIELHKE-KVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEP 203
P+ I+L K K+ + G H + ++ G F++ ++ K
Sbjct: 88 PKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDN------------------YSMKHL 129
Query: 204 SRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAF--LPVPQKIEAHC 261
+ L+ K + + G HS +L+ GE++ WG N HGQL F PQ +E
Sbjct: 130 RFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEH-- 187
Query: 262 FQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRP 321
+ I +G H +A + +G +++WG+ + GQLG G K D
Sbjct: 188 LAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGL------GHTESKDD-------- 233
Query: 322 PNSMPSSPHCLTGATE-----VSCGSEHN-LAIIGGVCYSWGWNEHGMCGDGTEANVWAP 375
P + G V+CG H+ L G+ +++G +HG G + N P
Sbjct: 234 -------PSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRP 286
Query: 376 KPVQALLSSSGLLVGCGAGHSLA 398
V L+ + CG H+LA
Sbjct: 287 CLVAELVGYRVTQIACGRWHTLA 309
Score = 62.0 bits (149), Expect = 1e-09
Identities = 54/205 (26%), Positives = 85/205 (41%), Gaps = 32/205 (15%)
Query: 200 AKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEA 259
A+ P + +N K V G++H L+ G+ + + + L E+
Sbjct: 85 ARTPKCIKLGKNMKIHSVDQGAEHMLILSSDGKPFEYDNYSMKHLRFESIL--------- 135
Query: 260 HCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCS 319
Q +K+ I G H +A ++ G++F WG+ +GQLG G K
Sbjct: 136 ---QEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLG------VGRKF---------- 176
Query: 320 RPPNSMPSSPHCLTGA--TEVSCGSEHNLAI-IGGVCYSWGWNEHGMCGDGTEANVWAPK 376
P + P L G ++S G H++A+ + G YSWG NE G G G + P
Sbjct: 177 -PSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPS 235
Query: 377 PVQALLSSSGLLVGCGAGHSLALCQ 401
++ L + V CG HS L Q
Sbjct: 236 LIEGLDNQKVEFVACGGSHSALLTQ 260
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 90.1 bits (222), Expect = 4e-18
Identities = 94/394 (23%), Positives = 154/394 (39%), Gaps = 72/394 (18%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
L++WG N GQLG G + V P+ + V G H+ +T+ G +F G N
Sbjct: 171 LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAAC-GRNHTLALTETGSVFAFGEN 229
Query: 77 KDGQLGLGH-TEDIPYFTPCKSLF-GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLG 134
K GQLGLG+ T+ +P +P + ++ G PI ++ACG +F++++ G + S G +GQLG
Sbjct: 230 KMGQLGLGNQTDAVP--SPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG 287
Query: 135 VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTL 194
+ Q IE E V + +
Sbjct: 288 HNSDGKFIARAQRIEYDCELV-----------------------------------PRRV 312
Query: 195 PLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN-EAAFLPV 253
+F + ++ + N V G++H+ L V+ WG +G+L + E V
Sbjct: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMV 372
Query: 254 PQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQD 313
P+ ++ F + I++G+T A +E G +F WG +
Sbjct: 373 PRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATN-------------------- 412
Query: 314 SFLPCSRPPNSMPSSPHCLTG--ATEVSCGSEHNLAIIGGVCYSWG----WNEHGMCGDG 367
SR P + L G ++CG + SWG + E G GD
Sbjct: 413 ----TSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY-GDH 467
Query: 368 TEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQ 401
+ A + V+ L V G HSL + +
Sbjct: 468 KPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
Score = 52.0 bits (123), Expect = 1e-06
Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 35/199 (17%)
Query: 10 AAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGD 69
A ++FA+G N GQLGLG++ D +P + + ++ G S ++ G+
Sbjct: 216 ALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGN 274
Query: 70 LFVCGLNKDGQLGLGHTEDIPYFTPCKSL-FGCP-------------------------I 103
L+ G + GQ LGH D + + + + C +
Sbjct: 275 LYSFGCPEYGQ--LGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVV 332
Query: 104 QQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHK---EKVVCIA 159
+ VACG + T++L +V S G +G+LG H ++ +VP+ ++L I
Sbjct: 333 RDVACGANHTLVLDSQKRVFSWGFGGYGRLG--HAEQKDEMVPRLVKLFDFPGRGASQIY 390
Query: 160 AGLRHAVAATASGIVFQWG 178
AG + A + G +F WG
Sbjct: 391 AGYTCSFAVSEVGGLFFWG 409
Score = 44.7 bits (104), Expect = 2e-04
Identities = 35/126 (27%), Positives = 52/126 (41%), Gaps = 18/126 (14%)
Query: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPH---CLTGA----- 335
G++ +G ++ +GRK ++ KQ + R PH CL G
Sbjct: 104 GQLLIFGATNWDLIGRK-------EVPKQQA---AYRNLGQNLWGPHRYGCLAGVRVRTV 153
Query: 336 TEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGH 395
SC + L G +SWG NE G G G V AP+ ++ L + CG H
Sbjct: 154 VSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNH 213
Query: 396 SLALCQ 401
+LAL +
Sbjct: 214 TLALTE 219
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 90.1 bits (222), Expect = 4e-18
Identities = 94/394 (23%), Positives = 154/394 (39%), Gaps = 72/394 (18%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
L++WG N GQLG G + V P+ + V G H+ +T+ G +F G N
Sbjct: 171 LWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAAC-GRNHTLALTETGSVFAFGEN 229
Query: 77 KDGQLGLGH-TEDIPYFTPCKSLF-GCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLG 134
K GQLGLG+ T+ +P +P + ++ G PI ++ACG +F++++ G + S G +GQLG
Sbjct: 230 KMGQLGLGNQTDAVP--SPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLG 287
Query: 135 VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTL 194
+ Q IE E V + +
Sbjct: 288 HNSDGKFIARAQRIEYDCELV-----------------------------------PRRV 312
Query: 195 PLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN-EAAFLPV 253
+F + ++ + N V G++H+ L V+ WG +G+L + E V
Sbjct: 313 AIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMV 372
Query: 254 PQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQD 313
P+ ++ F + I++G+T A +E G +F WG +
Sbjct: 373 PRLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWGATN-------------------- 412
Query: 314 SFLPCSRPPNSMPSSPHCLTG--ATEVSCGSEHNLAIIGGVCYSWG----WNEHGMCGDG 367
SR P + L G ++CG + SWG + E G GD
Sbjct: 413 ----TSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTISWGPSPTFGELGY-GDH 467
Query: 368 TEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQ 401
+ A + V+ L V G HSL + +
Sbjct: 468 KPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIAR 501
Score = 52.0 bits (123), Expect = 1e-06
Identities = 49/199 (24%), Positives = 85/199 (42%), Gaps = 35/199 (17%)
Query: 10 AAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGD 69
A ++FA+G N GQLGLG++ D +P + + ++ G S ++ G+
Sbjct: 216 ALTETGSVFAFGENKMGQLGLGNQTDA-VPSPAQIMYNGQPITKMACGAEFSMIMDCKGN 274
Query: 70 LFVCGLNKDGQLGLGHTEDIPYFTPCKSL-FGCP-------------------------I 103
L+ G + GQ LGH D + + + + C +
Sbjct: 275 LYSFGCPEYGQ--LGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVV 332
Query: 104 QQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRC-VVPQAIELHK---EKVVCIA 159
+ VACG + T++L +V S G +G+LG H ++ +VP+ ++L I
Sbjct: 333 RDVACGANHTLVLDSQKRVFSWGFGGYGRLG--HAEQKDEMVPRLVKLFDFPGRGASQIY 390
Query: 160 AGLRHAVAATASGIVFQWG 178
AG + A + G +F WG
Sbjct: 391 AGYTCSFAVSEVGGLFFWG 409
Score = 44.7 bits (104), Expect = 2e-04
Identities = 35/126 (27%), Positives = 52/126 (41%), Gaps = 18/126 (14%)
Query: 284 GKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPH---CLTGA----- 335
G++ +G ++ +GRK ++ KQ + R PH CL G
Sbjct: 104 GQLLIFGATNWDLIGRK-------EVPKQQA---AYRNLGQNLWGPHRYGCLAGVRVRTV 153
Query: 336 TEVSCGSEHNLAIIGGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGH 395
SC + L G +SWG NE G G G V AP+ ++ L + CG H
Sbjct: 154 VSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNH 213
Query: 396 SLALCQ 401
+LAL +
Sbjct: 214 TLALTE 219
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 85.5 bits (210), Expect = 9e-17
Identities = 82/279 (29%), Positives = 119/279 (42%), Gaps = 26/279 (9%)
Query: 39 PQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVC-----GLNKDGQLGLGHTEDIPYFT 93
PQ+L+ S R++ G H AVVT +L+ G GQLG G
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPK 418
Query: 94 PCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPH--GPRRCVVPQAIELH 151
+ L G I+QV+CG DFT+ +T+ GQ+ + GS+ +G +GV GP Q
Sbjct: 419 HVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFL 478
Query: 152 KEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLEN 211
V ++ G H V T + V+ WG G GR + ++T P +V +
Sbjct: 479 SNPVEQVSCGDNHVVVLTRNKEVYSWGCG--EYGRLGLDSE--EDYYT---PQKVDVPKA 531
Query: 212 SKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLA---------NEAAFLPVPQKIE---A 259
+ V G D + LT +G+V G N+ +L N A+ VP A
Sbjct: 532 LIIVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLA 591
Query: 260 HCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLG 298
K+ I G TH A E G++ T+G GQLG
Sbjct: 592 KQLSFYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG 630
Score = 82.4 bits (202), Expect = 8e-16
Identities = 82/357 (22%), Positives = 142/357 (39%), Gaps = 34/357 (9%)
Query: 17 LFAW-----GANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLF 71
L+ W G +GQLG G K P+ + + +++R+++ G + VTD G L+
Sbjct: 390 LYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKL-QGKAIRQVSCGDDFTVCVTDEGQLY 448
Query: 72 VCGLNKDGQLGLGHTEDIPYFTPCKSLF--GCPIQQVACGWDFTIMLTENGQVLSCGSNS 129
G + G +G+ P + F P++QV+CG + ++LT N +V S G
Sbjct: 449 AFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGE 508
Query: 130 FGQLGVP-----HGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGT----- 179
+G+LG+ + P++ VP+A+ +V + G T SG V G
Sbjct: 509 YGRLGLDSEEDYYTPQKVDVPKALI-----IVAVQCGCDGTFLLTQSGKVLACGLNEFNK 563
Query: 180 -GLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGS 238
GL C + + + L K + G H+A++ + G + +G
Sbjct: 564 LGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGRLLTFGC 623
Query: 239 NKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLG 298
NK GQL + + ++V + G +A T+ +F WG G+L
Sbjct: 624 NKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLA 683
Query: 299 RKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGVCYS 355
E+ C+ P + S H ++SC H + I+ V S
Sbjct: 684 MT-------PTERPHGSDICTSWPRPIFGSLH---HVPDLSCRGWHTILIVEKVLNS 730
Score = 55.8 bits (133), Expect = 8e-08
Identities = 51/192 (26%), Positives = 82/192 (42%), Gaps = 23/192 (11%)
Query: 217 VLAGSDHSASLTDAGEVYVW-----GSNKHGQLAN-EAAFLPVPQKIEAHCFQNEKVTAI 270
V AG+ H A +T E+Y W G+ HGQL + + A P+ +E Q + + +
Sbjct: 374 VCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEK--LQGKAIRQV 431
Query: 271 WSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPH 330
G V T+ G+++ +G YG +G K+ + P N S+P
Sbjct: 432 SCGDDFTVCVTDEGQLYAFGSDYYGCMGVD-------KVAGPEVLEPMQL--NFFLSNP- 481
Query: 331 CLTGATEVSCGSEHNLAIIGGV-CYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLV 389
+VSCG H + + YSWG E+G G +E + + P+ V + + V
Sbjct: 482 ----VEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAV 537
Query: 390 GCGAGHSLALCQ 401
CG + L Q
Sbjct: 538 QCGCDGTFLLTQ 549
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 85.1 bits (209), Expect = 1e-16
Identities = 89/333 (26%), Positives = 150/333 (45%), Gaps = 44/333 (13%)
Query: 39 PQQLNDFCKPRS---VRRITGGGGHSAVVTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPC 95
PQ ++ F + +S ++ + G +A +TD G + G +G LG G DI T
Sbjct: 378 PQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIV 437
Query: 96 KSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV----PHG-PRRCVVPQAIEL 150
++L G + QVACG + L+ ++ + G G+LG+ H P++ +P E
Sbjct: 438 EALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQE- 496
Query: 151 HKEKVVCIAAGLRHAVAATASGIVFQWGT------GL--ASCGRRLCPGQTL--PLFFTA 200
++VVC G+ ++ T G G+ GL S G P Q + L FT
Sbjct: 497 -AQRVVC---GIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTL 552
Query: 201 KEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL-ANEAAFLPVPQKIEA 259
+ L+ + + G+ HSA++T +G+ Y +GSN+HGQL N P K++
Sbjct: 553 LGSA---PLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQG 609
Query: 260 HCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCS 319
+ K+ + G VA ++++WG+ G+LGR+ +D+ LP
Sbjct: 610 --LEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRR----------DEDAGLP-- 655
Query: 320 RPPNSMPSSPHCLTGATEVSCGSEHNLAIIGGV 352
RP + P+ + T VSC + L + V
Sbjct: 656 RPVQLDETHPYTV---TSVSCCHGNTLLAVRSV 685
Score = 67.8 bits (164), Expect = 2e-11
Identities = 60/188 (31%), Positives = 82/188 (43%), Gaps = 20/188 (10%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
LFAWG G+LGLG +E PQQ+ + +R+ G S ++T G CG N
Sbjct: 464 LFAWGRGDSGRLGLGTRESHSCPQQV-PMPPGQEAQRVVCGIDSSMILTVPGQALACGSN 522
Query: 77 KDGQLGLGH----TEDIPY--------FTPCKS--LFGCPIQQVACGWDFTIMLTENGQV 122
+ +LGL H E +P+ FT S L P+ + G + +T +G
Sbjct: 523 RFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDC 582
Query: 123 LSCGSNSFGQLG--VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG 180
+ GSN GQLG G R Q +E K+ +A G VA A V+ WG G
Sbjct: 583 YTFGSNQHGQLGTNTRRGSRAPCKVQGLE--GIKMAMVACGDAFTVAIGAESEVYSWGKG 640
Query: 181 L-ASCGRR 187
GRR
Sbjct: 641 ARGRLGRR 648
Score = 67.4 bits (163), Expect = 3e-11
Identities = 79/339 (23%), Positives = 123/339 (36%), Gaps = 80/339 (23%)
Query: 134 GVPHGPRRCVVPQAIE----------------LHKEKVVCIAAGLRHAVAATASGIVFQW 177
G+P GP R +P + + +VV +AAG T SG + W
Sbjct: 297 GIPRGPVRPAIPPPLSSVYAWGGGLGTPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILW 356
Query: 178 -GTGLASCGRRLCPG---QTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEV 233
L + G L PG Q P F + + G V G +A LTD G +
Sbjct: 357 EAPPLGAGGGSLLPGAVEQPQPQFISRF----LEGQSGVTIKHVACGDFFTACLTDRGII 412
Query: 234 YVWGSNKHGQLANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRAD 293
+GS +G L + + + Q ++ + G +H++A + ++F WGR D
Sbjct: 413 MTFGSGSNGCLGH-GSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGD 471
Query: 294 YGQLGRKLETYEGWKLEKQ----------------DSFLPCSRPPNSMPSS--------- 328
G+LG L T E +Q DS + + P ++
Sbjct: 472 SGRLG--LGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGL 529
Query: 329 ----------PH---------CLTGAT--------EVSCGSEHNLAIIG-GVCYSWGWNE 360
PH L G+ + G+ H+ A+ G CY++G N+
Sbjct: 530 DHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQ 589
Query: 361 HGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLAL 399
HG G T AP VQ L +V CG ++A+
Sbjct: 590 HGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAI 628
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 80.5 bits (197), Expect = 3e-15
Identities = 99/362 (27%), Positives = 145/362 (40%), Gaps = 63/362 (17%)
Query: 17 LFAWGANSYGQLGLGHK--------EDVLLPQQLN---DFCKPRSVRRITGGGGHSAVVT 65
++ G N QLG E VL P ++ D + V +++ G HS V+T
Sbjct: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190
Query: 66 DGGDLFVCGLNKDGQLGLGHTEDIPYFTPCK----SLFGCPIQQVACGWDFTIMLTENGQ 121
D +F G N GQ G E+ Y + F + QVACG D ++ LT+ G+
Sbjct: 191 DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGE 250
Query: 122 VLSCGSNSFGQLGVPH-GPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG 180
V SCG + GQ G+ H +L V+ +A +A +A G +F WG
Sbjct: 251 VYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310
Query: 181 ----LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVW 236
LAS L F+ R +A C G A L G V+VW
Sbjct: 311 EYLQLASVTDSTQVNVPRCLHFSGVGKVR-------QAAC---GGTGCAVLNGEGHVFVW 360
Query: 237 GSNKHGQLAN--EAAFLPVPQKIEAHCF------QNEKVTAIWSGWTHLVAQTETGKMFT 288
G G+ N E+A VP+ I F +V+ I G +H A T G++F
Sbjct: 361 GYGILGKGPNLVESA---VPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFV 417
Query: 289 WGRADYGQL--GRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNL 346
WG+ G L GR + Y W++ +MP P +V+CG +H +
Sbjct: 418 WGKNIRGCLGIGRLEDQYFPWRV--------------TMPGEP------VDVACGVDHMV 457
Query: 347 AI 348
+
Sbjct: 458 TL 459
Score = 74.7 bits (182), Expect = 2e-13
Identities = 97/374 (25%), Positives = 149/374 (39%), Gaps = 67/374 (17%)
Query: 61 SAVVTDGGDLFVCGLNKDGQLGLGHT------------EDIPYFTPCKSLFGCPIQQVAC 108
S+ D ++ GLNKD QLG + E P P + QV+C
Sbjct: 122 SSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSC 181
Query: 109 GWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAI--ELHK--------EKVVCI 158
G +++LT+ V S G+NS+GQ G R VV I E H+ +VV +
Sbjct: 182 GRAHSLVLTDREGVFSMGNNSYGQCG------RKVVENEIYSESHRVHRMQDFDGQVVQV 235
Query: 159 AAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQT-LPLFFTAKEPSRVTG-LENSKAMC 216
A G H++ T G V+ G G GQT L + P+++ G L +
Sbjct: 236 ACGQDHSLFLTDKGEVYSCGWG--------ADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 287
Query: 217 VLAGSDHSASLTDAGEVYVWGSNKHGQLAN--EAAFLPVPQKIEAHCFQNEKVTAIWSGW 274
V D +++ G ++ WG++++ QLA+ ++ + VP+ + H KV G
Sbjct: 288 VATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--HFSGVGKVRQAACGG 345
Query: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLT- 333
T G +F WG YG LG+ E S P +P + LT
Sbjct: 346 TGCAVLNGEGHVFVWG---YGILGKGPNLVE-------------SAVPEMIPPTLFGLTE 389
Query: 334 -----GATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGL 387
+ + CG H A+ G + WG N G G G + + P V + +
Sbjct: 390 FNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--TMPGEPV 447
Query: 388 LVGCGAGHSLALCQ 401
V CG H + L +
Sbjct: 448 DVACGVDHMVTLAK 461
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 79.0 bits (193), Expect = 9e-15
Identities = 63/214 (29%), Positives = 95/214 (44%), Gaps = 37/214 (17%)
Query: 221 SDHSASLTDA---GEVYVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTH 276
SD+ A LT G V+ WG G+L + +PQ IE + V I G
Sbjct: 712 SDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIER--LNGQGVCQIECGAQF 769
Query: 277 LVAQTETGKMFTWGRADYGQLG-------RKLETYEGWKLEKQDSFLPCSRPPNSMPSSP 329
L+A T++G ++TWG+ DY +LG RKL+ EG + +K
Sbjct: 770 LLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKK------------------ 811
Query: 330 HCLTGATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLL 388
V+ G++H LA++ G Y+WG N+HG G+GT P VQ L +
Sbjct: 812 -----IVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMC 866
Query: 389 VGCGAGHSLALCQLPAHPALVQDPKVTYLSPDAI 422
V CG+ HS+A + V +P + + D +
Sbjct: 867 VACGSSHSVAWTTMDVATPSVHEPVLFQTARDPL 900
Score = 73.9 bits (180), Expect = 3e-13
Identities = 82/291 (28%), Positives = 119/291 (40%), Gaps = 46/291 (15%)
Query: 9 EAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSV--RRITGGGGHSAVVTD 66
EAA AAA G +Y GH++ + Q D P + + + G H
Sbjct: 616 EAAGAAAD----GVAAYSNYNNGHRKFLATAQNPADEPGPGAPAPQELGAAGKH------ 665
Query: 67 GGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACG-WDFT---------IML 116
GDL L Q + + P FG IQ + G W++ +L
Sbjct: 666 -GDLCEVSLTSSAQ------GEATWPHPVLFHFGEIIQDKSVGNWEYISTGKVSDNYALL 718
Query: 117 TE---NGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVC-IAAGLRHAVAATASG 172
T+ G V S G FG+LG G C +PQ IE + VC I G + +A T SG
Sbjct: 719 TKCEMGGLVFSWGDGDFGKLG-RGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSG 777
Query: 173 IVFQWGTG-LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAG 231
+V+ WG G G R ++ V GL K + V G+ H ++ D+G
Sbjct: 778 VVWTWGKGDYFRLGHRSD--------VHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSG 829
Query: 232 EVYVWGSNKHGQLANEAAFL-PVPQKIEAHCFQNEKVTAIWSGWTHLVAQT 281
+VY WG N HGQ N + P ++ + +K+ + G +H VA T
Sbjct: 830 QVYAWGDNDHGQQGNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSVAWT 878
Score = 59.3 bits (142), Expect = 7e-09
Identities = 46/161 (28%), Positives = 74/161 (45%), Gaps = 9/161 (5%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
+F+WG +G+LG G E +PQ + + V +I G +T G ++ G
Sbjct: 727 VFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWG-- 783
Query: 77 KDGQLGLGHTEDIPY--FTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLG 134
K LGH D+ + L G I VA G + + ++GQV + G N GQ G
Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 843
Query: 135 --VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGI 173
R+ ++ Q +E +K++C+A G H+VA T +
Sbjct: 844 NGTTTVNRKPMLVQGLE--GQKIMCVACGSSHSVAWTTMDV 882
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 77.8 bits (190), Expect = 2e-14
Identities = 83/291 (28%), Positives = 120/291 (41%), Gaps = 46/291 (15%)
Query: 9 EAAPAAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSV--RRITGGGGHSAVVTD 66
EAA AAA G +Y GH++ + Q D P + + + G H
Sbjct: 566 EAAGAAAD----GVAAYSNYNNGHRKFLATAQNPADEPGPGAPAPQELGAAGKH------ 615
Query: 67 GGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACG-WDFT---------IML 116
GDL L Q + + P FG IQ + G W++ +L
Sbjct: 616 -GDLCEVSLTSSAQ------GEATWPHPVLFHFGEIIQDKSVGNWEYISTGKVSDNYALL 668
Query: 117 TE---NGQVLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVC-IAAGLRHAVAATASG 172
T+ G V S G FG+LG G C +PQ IE + VC I G + +A T SG
Sbjct: 669 TKCEMGGLVFSWGDGDFGKLG-RGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSG 727
Query: 173 IVFQWGTG-LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAG 231
+V+ WG G G R ++P V GL K + V G+ H ++ D+G
Sbjct: 728 VVWTWGKGDYFRLGHRSD--------VHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSG 779
Query: 232 EVYVWGSNKHGQLANEAAFL-PVPQKIEAHCFQNEKVTAIWSGWTHLVAQT 281
+VY WG N HGQ N + P ++ + +K+ + G +H VA T
Sbjct: 780 QVYAWGDNDHGQQGNGTTTVNRKPMLVQG--LEGQKIMCVACGSSHSVAWT 828
Score = 76.3 bits (186), Expect = 6e-14
Identities = 62/214 (28%), Positives = 94/214 (43%), Gaps = 37/214 (17%)
Query: 221 SDHSASLTDA---GEVYVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTH 276
SD+ A LT G V+ WG G+L + +PQ IE + V I G
Sbjct: 662 SDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIER--LNGQGVCQIECGAQF 719
Query: 277 LVAQTETGKMFTWGRADYGQLG-------RKLETYEGWKLEKQDSFLPCSRPPNSMPSSP 329
L+A T++G ++TWG+ DY +LG RK + EG + +K
Sbjct: 720 LLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKK------------------ 761
Query: 330 HCLTGATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLL 388
V+ G++H LA++ G Y+WG N+HG G+GT P VQ L +
Sbjct: 762 -----IVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMC 816
Query: 389 VGCGAGHSLALCQLPAHPALVQDPKVTYLSPDAI 422
V CG+ HS+A + V +P + + D +
Sbjct: 817 VACGSSHSVAWTTMDVATPSVHEPVLFQTARDPL 850
Score = 61.6 bits (148), Expect = 1e-09
Identities = 47/161 (29%), Positives = 75/161 (46%), Gaps = 9/161 (5%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
+F+WG +G+LG G E +PQ + + V +I G +T G ++ G
Sbjct: 677 VFSWGDGDFGKLGRGGSEGCNIPQNIERL-NGQGVCQIECGAQFLLALTKSGVVWTWG-- 733
Query: 77 KDGQLGLGHTEDIPYFTP--CKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLG 134
K LGH D+ P + L G I VA G + + ++GQV + G N GQ G
Sbjct: 734 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 793
Query: 135 --VPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGI 173
R+ ++ Q +E +K++C+A G H+VA T +
Sbjct: 794 NGTTTVNRKPMLVQGLE--GQKIMCVACGSSHSVAWTTMDV 832
>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 76.6 bits (187), Expect = 4e-14
Identities = 70/237 (29%), Positives = 103/237 (43%), Gaps = 22/237 (9%)
Query: 21 GANSYGQLGLGHKEDVLLPQ-----QLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
G NSYGQ G E+ + + ++ DF V ++ G HS +TD G+++ CG
Sbjct: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 59
Query: 76 NKDGQLGLGHTEDIPYFTPCK---SLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQ 132
DGQ GLGH +P K L G + QVA D + ++ +G + G++ + Q
Sbjct: 60 GADGQTGLGHYNITS--SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQ 117
Query: 133 LGVPHGPRRCVVPQAIELH-KEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRL--- 188
L + VP+ + KV A G G VF WG G+ G L
Sbjct: 118 LASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVES 177
Query: 189 -CPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL 244
P P F E + ++ S+ C G A+LT+ GE++VWG N G L
Sbjct: 178 AVPEMIPPTLFGLTEFN--PEIQVSRIRC---GLSRFAALTNKGELFVWGKNIRGCL 229
Score = 64.3 bits (155), Expect = 2e-10
Identities = 73/265 (27%), Positives = 107/265 (40%), Gaps = 48/265 (18%)
Query: 99 FGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPH-GPRRCVVPQAIELHKEKVVC 157
F + QVACG D ++ LT+ G+V SCG + GQ G+ H +L V+
Sbjct: 31 FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 90
Query: 158 IAAGLRHAVAATASGIVFQWGTG----LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSK 213
+A +A +A G +F WG LAS L F+ R +
Sbjct: 91 VATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVR-------Q 143
Query: 214 AMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN--EAAFLPVPQKIEAHCF------QNE 265
A C G A L G V+VWG G+ N E+A VP+ I F
Sbjct: 144 AAC---GGTGCAVLNGEGHVFVWGYGILGKGPNLVESA---VPEMIPPTLFGLTEFNPEI 197
Query: 266 KVTAIWSGWTHLVAQTETGKMFTWGRADYGQL--GRKLETYEGWKLEKQDSFLPCSRPPN 323
+V+ I G + A T G++F WG+ G L GR + Y W++
Sbjct: 198 QVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-------------- 243
Query: 324 SMPSSPHCLTGATEVSCGSEHNLAI 348
+MP P +V+CG +H + +
Sbjct: 244 TMPGEP------VDVACGVDHMVTL 262
Score = 46.2 bits (108), Expect = 6e-05
Identities = 39/111 (35%), Positives = 55/111 (49%), Gaps = 13/111 (11%)
Query: 17 LFAWGANSYGQLGLG-HKEDVLLPQQ-------LNDFCKPRSVRRITGGGGHSAVVTDGG 68
+F WG YG LG G + + +P+ L +F V RI G A +T+ G
Sbjct: 160 VFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKG 216
Query: 69 DLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
+LFV G N G LG+G ED YF ++ G P+ VACG D + L ++
Sbjct: 217 ELFVWGKNIRGCLGIGRLED-QYFPWRVTMPGEPV-DVACGVDHMVTLAKS 265
>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 76.6 bits (187), Expect = 4e-14
Identities = 70/237 (29%), Positives = 103/237 (43%), Gaps = 22/237 (9%)
Query: 21 GANSYGQLGLGHKEDVLLPQ-----QLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGL 75
G NSYGQ G E+ + + ++ DF V ++ G HS +TD G+++ CG
Sbjct: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 59
Query: 76 NKDGQLGLGHTEDIPYFTPCK---SLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQ 132
DGQ GLGH +P K L G + QVA D + ++ +G + G++ + Q
Sbjct: 60 GADGQTGLGHYNITS--SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQ 117
Query: 133 LGVPHGPRRCVVPQAIELH-KEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRL--- 188
L + VP+ + KV A G G VF WG G+ G L
Sbjct: 118 LASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVES 177
Query: 189 -CPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQL 244
P P F E + ++ S+ C G A+LT+ GE++VWG N G L
Sbjct: 178 AVPEMIPPTLFGLTEFN--PEIQVSRIRC---GLSRFAALTNKGELFVWGKNIRGCL 229
Score = 64.3 bits (155), Expect = 2e-10
Identities = 73/265 (27%), Positives = 107/265 (40%), Gaps = 48/265 (18%)
Query: 99 FGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPH-GPRRCVVPQAIELHKEKVVC 157
F + QVACG D ++ LT+ G+V SCG + GQ G+ H +L V+
Sbjct: 31 FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 90
Query: 158 IAAGLRHAVAATASGIVFQWGTG----LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSK 213
+A +A +A G +F WG LAS L F+ R +
Sbjct: 91 VATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVR-------Q 143
Query: 214 AMCVLAGSDHSASLTDAGEVYVWGSNKHGQLAN--EAAFLPVPQKIEAHCF------QNE 265
A C G A L G V+VWG G+ N E+A VP+ I F
Sbjct: 144 AAC---GGTGCAVLNGEGHVFVWGYGILGKGPNLVESA---VPEMIPPTLFGLTEFNPEI 197
Query: 266 KVTAIWSGWTHLVAQTETGKMFTWGRADYGQL--GRKLETYEGWKLEKQDSFLPCSRPPN 323
+V+ I G + A T G++F WG+ G L GR + Y W++
Sbjct: 198 QVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-------------- 243
Query: 324 SMPSSPHCLTGATEVSCGSEHNLAI 348
+MP P +V+CG +H + +
Sbjct: 244 TMPGEP------VDVACGVDHMVTL 262
Score = 46.2 bits (108), Expect = 6e-05
Identities = 39/111 (35%), Positives = 55/111 (49%), Gaps = 13/111 (11%)
Query: 17 LFAWGANSYGQLGLG-HKEDVLLPQQ-------LNDFCKPRSVRRITGGGGHSAVVTDGG 68
+F WG YG LG G + + +P+ L +F V RI G A +T+ G
Sbjct: 160 VFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKG 216
Query: 69 DLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTEN 119
+LFV G N G LG+G ED YF ++ G P+ VACG D + L ++
Sbjct: 217 ELFVWGKNIRGCLGIGRLED-QYFPWRVTMPGEPV-DVACGVDHMVTLAKS 265
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 74.3 bits (181), Expect = 2e-13
Identities = 53/163 (32%), Positives = 76/163 (46%), Gaps = 14/163 (8%)
Query: 122 VLSCGSNSFGQLGVPHGPRRCVVPQAIELHKEKVVC-IAAGLRHAVAATASGIVFQWGTG 180
V S G FG+LG G C +PQ IE + VC I G + +A T SG+V+ WG G
Sbjct: 25 VFSWGDGDFGKLG-RGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
Query: 181 -LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSN 239
G R ++P V GL K + V G+ H ++ D+G+VY WG N
Sbjct: 84 DYFRLGHRSD--------VHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDN 135
Query: 240 KHGQLANEAAFL-PVPQKIEAHCFQNEKVTAIWSGWTHLVAQT 281
HGQ N + P ++ + +K+ + G +H VA T
Sbjct: 136 DHGQQGNGTTTVNRKPTLVQG--LEGQKIMCVACGSSHSVAWT 176
Score = 72.8 bits (177), Expect = 6e-13
Identities = 56/199 (28%), Positives = 87/199 (43%), Gaps = 34/199 (17%)
Query: 233 VYVWGSNKHGQLANEAAF-LPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGR 291
V+ WG G+L + +PQ IE + V I G L+A T++G ++TWG+
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIER--LNGQGVCQIECGAQFLLALTKSGVVWTWGK 82
Query: 292 ADYGQLG-------RKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEH 344
DY +LG RK + EG + +K V+ G++H
Sbjct: 83 GDYFRLGHRSDVHVRKPQVVEGLRGKK-----------------------IVHVAVGAQH 119
Query: 345 NLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLALCQLP 403
LA++ G Y+WG N+HG G+GT P VQ L + V CG+ HS+A +
Sbjct: 120 CLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVD 179
Query: 404 AHPALVQDPKVTYLSPDAI 422
V +P + + D +
Sbjct: 180 VATPSVHEPVLFQTARDPL 198
Score = 67.4 bits (163), Expect = 3e-11
Identities = 51/160 (31%), Positives = 77/160 (48%), Gaps = 9/160 (5%)
Query: 70 LFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNS 129
+F G G+LG G +E + L G + Q+ CG F + LT++G V + G
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
Query: 130 FGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRL 188
+ +LG PQ +E L +K+V +A G +H +A SG V+ WG G++
Sbjct: 85 YFRLG-HRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDN--DHGQQG 141
Query: 189 CPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLT 228
T+ ++P+ V GLE K MCV GS HS + T
Sbjct: 142 NGTTTV-----NRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 60.8 bits (146), Expect = 2e-09
Identities = 47/157 (29%), Positives = 74/157 (47%), Gaps = 9/157 (5%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
+F+WG +G+LG G E +PQ + + + V +I G +T G ++ G
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNI-ERLNGQGVCQIECGAQFLLALTKSGVVWTWG-- 81
Query: 77 KDGQLGLGHTEDIPYFTP--CKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQL- 133
K LGH D+ P + L G I VA G + + ++GQV + G N GQ
Sbjct: 82 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 141
Query: 134 -GVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAAT 169
G R+ + Q +E +K++C+A G H+VA T
Sbjct: 142 NGTTTVNRKPTLVQGLE--GQKIMCVACGSSHSVAWT 176
>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
Length = 1353
Score = 72.8 bits (177), Expect = 6e-13
Identities = 63/237 (26%), Positives = 109/237 (45%), Gaps = 11/237 (4%)
Query: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRS-VRRITGGGGHSAVVTDGGDLFVCGL 75
++ WG N+ LG G + P+ ++ F + ++++ HS ++ G ++ CG
Sbjct: 144 VYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCGH 203
Query: 76 NKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNSFGQLGV 135
G+LG G + + L G QVA D T++LTE+G V + G N F QLG+
Sbjct: 204 GPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLGI 263
Query: 136 PHGPRRCVVPQAIE---LHKEKVVCIAAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQ 192
P C VP+ I+ L ++ +AAG H V T V+ G G L P
Sbjct: 264 IPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWTREA-VYTMGLNGGQLGCLLDPNG 322
Query: 193 TLPLFFTAKEPSRVTGLENSK-AMCVLAGSD-HSASLTDAGEVYVWGSNKHGQLANE 247
P +V+ L + A+ ++A SD + +T G++Y+ + ++A++
Sbjct: 323 EK----CVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGDIYLLADYQCKKMASK 375
Score = 33.1 bits (74), Expect = 0.54
Identities = 22/77 (28%), Positives = 36/77 (46%), Gaps = 3/77 (3%)
Query: 223 HSASLTDAGEVYVWGSNKHGQLAN-EAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQT 281
HS L+ G+VY G G+L + + VP+ +E + + + H V T
Sbjct: 188 HSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEG--LNGHNCSQVAAAKDHTVVLT 245
Query: 282 ETGKMFTWGRADYGQLG 298
E G ++T+G + QLG
Sbjct: 246 EDGCVYTFGLNIFHQLG 262
Score = 29.6 bits (65), Expect = 6.0
Identities = 36/172 (20%), Positives = 67/172 (38%), Gaps = 23/172 (13%)
Query: 228 TDAGEVYVWGSNKHGQLANEAA-FLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKM 286
TD +VY WG N + L + + P+ ++ + + H V ++ G++
Sbjct: 139 TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQV 198
Query: 287 FTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNL 346
+T G G+LG E C P + H ++V+ +H +
Sbjct: 199 YTCGHGPGGRLGHGDEQ-------------TCLVPRLVEGLNGH---NCSQVAAAKDHTV 242
Query: 347 AII-GGVCYSWGWN---EHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAG 394
+ G Y++G N + G+ + NV P+ +QA ++G AG
Sbjct: 243 VLTEDGCVYTFGLNIFHQLGIIPPPSSCNV--PRQIQAKYLKGRTIIGVAAG 292
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 66.6 bits (161), Expect = 4e-11
Identities = 83/353 (23%), Positives = 131/353 (37%), Gaps = 66/353 (18%)
Query: 73 CGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNS--- 129
CG ++ LG G + +P ++ G I +V+ W +T +T G++ GS S
Sbjct: 15 CGFGQE--LGSGRGRQVHSPSPLRA--GVDICRVSASWSYTAFVTRGGRLELSGSASGAA 70
Query: 130 ------------FGQLGVPHGPRRCVVPQAIE-------LHKEKVVCIAAGLRHAVAATA 170
L GP + A E L + VV A G
Sbjct: 71 GRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
Query: 171 SGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDA 230
+G + L C R + P + R LE G++H+ L A
Sbjct: 131 AGRL-----PLLPCARAYVSPRA-PFYRPLAPELRARQLE--------LGAEHALLLDAA 176
Query: 231 GEVYVWGSNKHGQLANEAAFLPV-PQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTW 289
G+V+ WG +HGQL + + P+ +EA Q + + +G H V +ETG ++ W
Sbjct: 177 GQVFSWGGGRHGQLGHGTLEAELEPRLLEA--LQGLVMAEVAAGGWHSVCVSETGDIYIW 234
Query: 290 GRADYGQLG---RKL----ETYEGWKLEKQDSFLPCSRPPNSMPSSPHCL---------- 332
G + GQL R L ET E + R + +P
Sbjct: 235 GWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALL 294
Query: 333 -----TGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQ 379
+ A + SCGS H + G Y+WGW ++G G ++ P+ V+
Sbjct: 295 DLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
Score = 63.5 bits (153), Expect = 4e-10
Identities = 65/220 (29%), Positives = 96/220 (43%), Gaps = 43/220 (19%)
Query: 104 QQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVV-PQAIELHKEKVVC-IAAG 161
+Q+ G + ++L GQV S G GQLG HG + P+ +E + V+ +AAG
Sbjct: 161 RQLELGAEHALLLDAAGQVFSWGGGRHGQLG--HGTLEAELEPRLLEALQGLVMAEVAAG 218
Query: 162 LRHAVAATASGIVFQWGTG----LASCGRRLCP-GQTL---------------------- 194
H+V + +G ++ WG LA R L G+T+
Sbjct: 219 GWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAED 278
Query: 195 --PLFFTAKEPSRVT-----GLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANE 247
P F A +P G + KA C GS H+A +T GE+Y WG K+GQL +E
Sbjct: 279 GAPAPFIAVQPFPALLDLPMGSDAVKASC---GSRHTAVVTRTGELYTWGWGKYGQLGHE 335
Query: 248 -AAFLPVPQKIEAHCFQNEKVTAIWSG-WTHLVAQTETGK 285
L P+++E + +V A+ G W V E GK
Sbjct: 336 DTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
Score = 58.9 bits (141), Expect = 9e-09
Identities = 85/353 (24%), Positives = 123/353 (34%), Gaps = 93/353 (26%)
Query: 16 ALFAWGANSYGQ-LGLGHKEDVLLPQQLN---DFCKPRSVRRITGGGGHSAVVTDGGDLF 71
A F +G +GQ LG G V P L D C R++ ++A VT GG L
Sbjct: 8 AWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDIC------RVSASWSYTAFVTRGGRLE 61
Query: 72 VCGLN-------KDG----------QLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTI 114
+ G KD + G G + + +L G P+ W +
Sbjct: 62 LSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPL------WAQNV 115
Query: 115 MLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAI-------ELHKEKVVCIAAGLRHAVA 167
+ G+ G G+L + R V P+A EL + + G HA+
Sbjct: 116 VPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQ---LELGAEHALL 172
Query: 168 ATASGIVFQWGTGL-ASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSAS 226
A+G VF WG G G + EP + L+ V AG HS
Sbjct: 173 LDAAGQVFSWGGGRHGQLGHGTLEAEL--------EPRLLEALQGLVMAEVAAGGWHSVC 224
Query: 227 LTDAGEVYVWGSNKHGQLA--------------------NE------------------- 247
+++ G++Y+WG N+ GQLA NE
Sbjct: 225 VSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPF 284
Query: 248 AAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRK 300
A P P ++ G H T TG+++TWG YGQLG +
Sbjct: 285 IAVQPFPALLDLP--MGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
Score = 56.6 bits (135), Expect = 5e-08
Identities = 44/160 (27%), Positives = 69/160 (43%), Gaps = 39/160 (24%)
Query: 13 AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72
AA +F+WG +GQLG G E L P+ L + + + + GG HS V++ GD+++
Sbjct: 175 AAGQVFSWGGGRHGQLGHGTLEAELEPRLL-EALQGLVMAEVAAGGWHSVCVSETGDIYI 233
Query: 73 CGLNKDGQLGL-----------------------------GHTED---IPYFT--PCKSL 98
G N+ GQL L G ED P+ P +L
Sbjct: 234 WGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPAL 293
Query: 99 FGCPI----QQVACGWDFTIMLTENGQVLSCGSNSFGQLG 134
P+ + +CG T ++T G++ + G +GQLG
Sbjct: 294 LDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
Score = 39.7 bits (91), Expect = 0.006
Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 316 LPCSRP------PNSMPSSPHCLTGATEVSCGSEHNLAI-IGGVCYSWGWNEHGMCGDGT 368
LPC+R P P +P A ++ G+EH L + G +SWG HG G GT
Sbjct: 137 LPCARAYVSPRAPFYRPLAPELR--ARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT 194
Query: 369 EANVWAPKPVQALLSSSGLLVGCGAGHSLALCQ 401
P+ ++AL V G HS+ + +
Sbjct: 195 LEAELEPRLLEALQGLVMAEVAAGGWHSVCVSE 227
Score = 33.9 bits (76), Expect = 0.32
Identities = 25/72 (34%), Positives = 34/72 (47%), Gaps = 11/72 (15%)
Query: 57 GGGHSAVVTDGGDLFVCGLNKDGQLG------LGHTEDIPYFTPCKSLFGCPIQQVACG- 109
G H+AVVT G+L+ G K GQLG L + YF K L ++ V CG
Sbjct: 308 GSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVD-KQL---QVKAVTCGP 363
Query: 110 WDFTIMLTENGQ 121
W+ + E G+
Sbjct: 364 WNTYVYAVEKGK 375
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.431
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 19,931,057
Number of Sequences: 37866
Number of extensions: 953628
Number of successful extensions: 3127
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 40
Number of HSP's successfully gapped in prelim test: 6
Number of HSP's that attempted gapping in prelim test: 2254
Number of HSP's gapped (non-prelim): 228
length of query: 458
length of database: 18,247,518
effective HSP length: 106
effective length of query: 352
effective length of database: 14,233,722
effective search space: 5010270144
effective search space used: 5010270144
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.