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Search of human proteins with 65301167
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|65301167 very low density lipoprotein receptor isoform a
[Homo sapiens]
(873 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 1873 0.0
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 1802 0.0
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 911 0.0
gi|65301119 low density lipoprotein receptor-related protein 8 i... 901 0.0
gi|61744471 low density lipoprotein receptor-related protein 8 i... 896 0.0
gi|61744467 low density lipoprotein receptor-related protein 8 i... 690 0.0
gi|66082554 low density lipoprotein receptor-related protein 8 i... 655 0.0
gi|157384998 low density lipoprotein receptor-related protein 4 ... 603 e-172
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 542 e-154
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 522 e-148
gi|93102379 low density lipoprotein-related protein 1B precursor... 520 e-147
gi|4507157 sortilin-related receptor containing LDLR class A rep... 252 1e-66
gi|119709832 low density lipoprotein receptor-related protein 5 ... 248 1e-65
gi|148727288 low density lipoprotein receptor-related protein 6 ... 244 2e-64
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 217 4e-56
gi|134031945 SCO-spondin [Homo sapiens] 181 3e-45
gi|29244926 corin [Homo sapiens] 177 3e-44
gi|11415040 matriptase [Homo sapiens] 145 2e-34
gi|115298674 nidogen 1 precursor [Homo sapiens] 137 4e-32
gi|144953895 nidogen 2 precursor [Homo sapiens] 133 8e-31
gi|32698824 low density lipoprotein receptor-related protein 5-l... 126 1e-28
gi|209447022 low density lipoprotein receptor-related protein 5-... 126 1e-28
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 122 1e-27
gi|24430141 fibrillin 1 precursor [Homo sapiens] 118 2e-26
gi|66346695 fibrillin 2 precursor [Homo sapiens] 108 2e-23
gi|28557796 low density lipoprotein receptor class A domain cont... 108 2e-23
gi|7706111 8D6 antigen [Homo sapiens] 107 6e-23
gi|46249414 latent transforming growth factor beta binding prote... 105 2e-22
gi|46249412 latent transforming growth factor beta binding prote... 105 2e-22
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens] 103 7e-22
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 1873 bits (4852), Expect = 0.0
Identities = 873/873 (100%), Positives = 873/873 (100%)
Query: 1 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 60
MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
Sbjct: 1 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 60
Query: 61 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
Sbjct: 61 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
Query: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180
GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
Sbjct: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180
Query: 181 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240
DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
Sbjct: 181 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240
Query: 241 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300
ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
Sbjct: 241 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300
Query: 301 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 360
RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
Sbjct: 301 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 360
Query: 361 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 420
LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
Sbjct: 361 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 420
Query: 421 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480
CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
Sbjct: 421 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480
Query: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 540
QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 540
Query: 541 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
Sbjct: 541 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
Query: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
Sbjct: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
Query: 661 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 720
DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
Sbjct: 661 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 720
Query: 721 PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI 780
PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI
Sbjct: 721 PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI 780
Query: 781 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 840
NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
Sbjct: 781 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 840
Query: 841 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 873
TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
Sbjct: 841 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 873
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 1802 bits (4668), Expect = 0.0
Identities = 844/873 (96%), Positives = 844/873 (96%), Gaps = 28/873 (3%)
Query: 1 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 60
MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
Sbjct: 1 MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 60
Query: 61 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
Sbjct: 61 GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
Query: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180
GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
Sbjct: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180
Query: 181 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240
DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
Sbjct: 181 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240
Query: 241 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300
ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
Sbjct: 241 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300
Query: 301 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 360
RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
Sbjct: 301 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 360
Query: 361 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 420
LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
Sbjct: 361 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 420
Query: 421 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480
CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
Sbjct: 421 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480
Query: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 540
QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 540
Query: 541 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
Sbjct: 541 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
Query: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
Sbjct: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
Query: 661 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 720
DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
Sbjct: 661 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 720
Query: 721 PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI 780
PAPQINDHSPKYTCSCPSGYNVEENGRDCQ I
Sbjct: 721 PAPQINDHSPKYTCSCPSGYNVEENGRDCQR----------------------------I 752
Query: 781 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 840
NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
Sbjct: 753 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 812
Query: 841 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 873
TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
Sbjct: 813 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 845
>gi|4504975 low density lipoprotein receptor precursor [Homo
sapiens]
Length = 860
Score = 911 bits (2354), Expect = 0.0
Identities = 425/841 (50%), Positives = 552/841 (65%), Gaps = 46/841 (5%)
Query: 72 CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVS 131
C ++F C +G+C+ +W CDG +C+DGSDES E C TC+ + SCG +CIP
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86
Query: 132 WRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPP 191
WRCDG+ DCD+G DE+ C TCS DEF C G+CISR FVC+ DC DGSDE C
Sbjct: 87 WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL 146
Query: 192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH---TKCPASEIQCGS 248
TCG FQC++S+CIP W CD+D DC D SDE ++C V + C A E C S
Sbjct: 147 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLS 206
Query: 249 GECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSD 308
GECIH WRCDG PDCKD SDE NC TCRPD+F+C DG+CIHGSRQC+ DC D SD
Sbjct: 207 GECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSD 266
Query: 309 EVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCS 368
EV C NV C GP KFKC SGECI + KVCN +DCRDWSDEP+KEC NECL NNGGCS
Sbjct: 267 EVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCS 326
Query: 369 HICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMD 428
H+C DL IGYEC C GF+L+ ++ C DIDECQ+P CSQ+C+NL+GGYKC+C G+Q+D
Sbjct: 327 HVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLD 386
Query: 429 LATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADL 488
T CKAVG L FTNR ++RK+ L+R EY L+ LRN VALD ++A+ +++W+DL
Sbjct: 387 PHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDL 446
Query: 489 SQKAIFSASIDDKVGRHVKMIDNVYN-----PAAIAVDWVYKTIYWTDAASKTISVATLD 543
SQ+ I S +D G V D V + P +AVDW++ IYWTD+ T+SVA
Sbjct: 447 SQRMICSTQLDRAHG--VSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTK 504
Query: 544 GTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPN 603
G KRK LF + +P +I VDP+ GF+YW+DWG PAKI+K G+NG D LVT +IQWPN
Sbjct: 505 GVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPN 564
Query: 604 GITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGE 663
GITLDL+ RLYW+DSKLH +SS+D+NG +R+ +L+ + LAHP +L +FED+V+W D
Sbjct: 565 GITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII 624
Query: 664 NEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEE-DMENGGCEYLCLPA 722
NEA++ AN+ TGS++ L NL +D++++H L QP G NWCE + NGGC+YLCLPA
Sbjct: 625 NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPA 684
Query: 723 PQINDHSPKYTCSCPSGYNVEENGRDC----------QSTAT-----TVTYSETKDTNTT 767
PQIN HSPK+TC+CP G + + R C Q T+T + T T+ T T
Sbjct: 685 PQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTR 744
Query: 768 EISATSGLVPGGINVTTAVSEVSV---------------PPKGTSAAWAILPLLLLVMAA 812
+ TS L PG T V V++ P A +LP++LLV
Sbjct: 745 PVPDTSRL-PGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLC 803
Query: 813 VGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDL 872
+G +L+W+NW+ KN+ S+NFDNPVY KTTE+++ I + G++YP+ +VS +DD+
Sbjct: 804 LGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQD----GYSYPSRQMVSLEDDV 859
Query: 873 A 873
A
Sbjct: 860 A 860
Score = 96.3 bits (238), Expect = 1e-19
Identities = 49/137 (35%), Positives = 66/137 (48%), Gaps = 4/137 (2%)
Query: 28 GRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS 87
G + C +F C +G CI W+CDG DC D SDE+NC TC +F C++G C+
Sbjct: 192 GDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHG 251
Query: 88 RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE- 146
+CD + DC+D SDE C T HS +CI + C+ DC DE
Sbjct: 252 SRQCDREYDCKDMSDE--VGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEP 309
Query: 147 -ENCGNITCSPDEFTCS 162
+ CG C + CS
Sbjct: 310 IKECGTNECLDNNGGCS 326
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 901 bits (2328), Expect = 0.0
Identities = 440/933 (47%), Positives = 587/933 (62%), Gaps = 110/933 (11%)
Query: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
Query: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
Query: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDD 178
SCG S +C+P SWRCDGE DC+ G DE C + C+P EF C + C++ FVC+G DD
Sbjct: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDD 191
Query: 179 CSDGSDELDCAPPTCGAHEFQC---STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235
C DGSDE CA P CG EF+C +CIP WVCD DC D+SDE+ E CGR
Sbjct: 192 CGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251
Query: 236 HTKCP-----ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC 290
T P AS+ C SGEC+H WRCDGD DCKD SDE +CP TCR D+F+C DG+C
Sbjct: 252 ATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311
Query: 291 IHGSRQCNGIRDCVDGSDEVNC-KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSD 349
+ + CN +DC DGSDE C + +N+CL
Sbjct: 312 VLAIKHCNQEQDCPDGSDEAGCLQGLNECLH----------------------------- 342
Query: 350 EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQI 409
NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P CSQI
Sbjct: 343 -------------NNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQI 389
Query: 410 CINLKGGYKCECSRGYQMDLATGVCK-AVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL 468
C+N KG +KCEC GY+MDL T CK A GK PSLIFTNR ++R+I L ++ Y +L+ L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 449
Query: 469 RNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYK 525
+N VALD ++A +++W DLS + I+SA +D D + V + + +++P +AVDWV+K
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 526 TIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAG 585
IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 586 MNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645
+NG DR+ LV+ +I+WPNGITLDL+ RLYW+DSKLH LSS+D +G +R+ ++ S +FL+
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 629
Query: 646 HPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW 705
HP + +FED+V+W D ENEA++ AN+ G E++ L NLN+ DI+++HEL QP +
Sbjct: 630 HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 689
Query: 706 CEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPS----GYNVEENGRDCQSTAT------ 754
CE ++ NGGCEYLCLPAPQI+ HSPKYTC+CP G +++ R QST+T
Sbjct: 690 CELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLAST 749
Query: 755 -------------TVTYSETKDTNTTEISATSGLVPGGINVTTA--VSEVSVPP------ 793
T + T ++TE + + VP ++V A +S ++ P
Sbjct: 750 MTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHS 809
Query: 794 ---------KGTSAAWA----ILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 840
G++ A I+P++++ + + GYL+WRNW+ KN KSMNFDNPVY KT
Sbjct: 810 QHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKT 869
Query: 841 TEE--DLSIDIGRHSASVGHTYPAISVVSTDDD 871
TEE + + IGR +A +GH YPA +S +DD
Sbjct: 870 TEEEDEDELHIGR-TAQIGHVYPARVALSLEDD 901
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 896 bits (2315), Expect = 0.0
Identities = 437/924 (47%), Positives = 582/924 (62%), Gaps = 110/924 (11%)
Query: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
Query: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
Query: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDD 178
SCG S +C+P SWRCDGE DC+ G DE C + C+P EF C + C++ FVC+G DD
Sbjct: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDD 191
Query: 179 CSDGSDELDCAPPTCGAHEFQC---STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235
C DGSDE CA P CG EF+C +CIP WVCD DC D+SDE+ E CGR
Sbjct: 192 CGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251
Query: 236 HTKCP-----ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC 290
T P AS+ C SGEC+H WRCDGD DCKD SDE +CP TCR D+F+C DG+C
Sbjct: 252 ATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311
Query: 291 IHGSRQCNGIRDCVDGSDEVNC-KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSD 349
+ + CN +DC DGSDE C + +N+CL
Sbjct: 312 VLAIKHCNQEQDCPDGSDEAGCLQGLNECLH----------------------------- 342
Query: 350 EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQI 409
NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P CSQI
Sbjct: 343 -------------NNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQI 389
Query: 410 CINLKGGYKCECSRGYQMDLATGVCK-AVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL 468
C+N KG +KCEC GY+MDL T CK A GK PSLIFTNR ++R+I L ++ Y +L+ L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 449
Query: 469 RNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYK 525
+N VALD ++A +++W DLS + I+SA +D D + V + + +++P +AVDWV+K
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509
Query: 526 TIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAG 585
IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569
Query: 586 MNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645
+NG DR+ LV+ +I+WPNGITLDL+ RLYW+DSKLH LSS+D +G +R+ ++ S +FL+
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 629
Query: 646 HPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW 705
HP + +FED+V+W D ENEA++ AN+ G E++ L NLN+ DI+++HEL QP +
Sbjct: 630 HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 689
Query: 706 CEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPS----GYNVEENGRDCQSTAT------ 754
CE ++ NGGCEYLCLPAPQI+ HSPKYTC+CP G +++ R QST+T
Sbjct: 690 CELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLAST 749
Query: 755 -------------TVTYSETKDTNTTEISATSGLVPGGINVTTA--VSEVSVPP------ 793
T + T ++TE + + VP ++V A +S ++ P
Sbjct: 750 MTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHS 809
Query: 794 ---------KGTSAAWA----ILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 840
G++ A I+P++++ + + GYL+WRNW+ KN KSMNFDNPVY KT
Sbjct: 810 QHYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKT 869
Query: 841 TEE--DLSIDIGRHSASVGHTYPA 862
TEE + + IGR +A +GH YPA
Sbjct: 870 TEEEDEDELHIGR-TAQIGHVYPA 892
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 690 bits (1781), Expect = 0.0
Identities = 332/691 (48%), Positives = 457/691 (66%), Gaps = 52/691 (7%)
Query: 193 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECI 252
C +FQC CIP W CD+D DC D SDE + C ++ C S+ C +G CI
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDCPKKT-----CADSDFTCDNGHCI 99
Query: 253 HKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFECEDGS--CIHGSRQCNGIRDCVDGSD 308
H++W+CDG+ +C DGSDE C + C ++ C S C+ S +C+G +DC G+D
Sbjct: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159
Query: 309 EVNCK-NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGC 367
E C ++ C G +F+C G C+ K CNQEQDC D SDE +NECL NNGGC
Sbjct: 160 EAGCATSLGTCRGD-EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 218
Query: 368 SHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQM 427
SHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P CSQIC+N KG +KCEC GY+M
Sbjct: 219 SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEM 278
Query: 428 DLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
DL T CKA GK PSLIFTNR ++R+I L ++ Y +L+ L+N VALD ++A +++W
Sbjct: 279 DLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWC 338
Query: 487 DLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD 543
DLS + I+SA +D D + V + + +++P +AVDWV+K IYWTD+ +KTISVAT+D
Sbjct: 339 DLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVD 398
Query: 544 GTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPN 603
G +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+NG DR+ LV+ +I+WPN
Sbjct: 399 GGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPN 458
Query: 604 GITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGE 663
GITLDL+ RLYW+DSKLH LSS+D +G +R+ ++ S +FL+HP + +FED+V+W D E
Sbjct: 459 GITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLE 518
Query: 664 NEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDME-NGGCEYLCLPA 722
NEA++ AN+ G E++ L NLN+ DI+++HEL QP + CE ++ NGGCEYLCLPA
Sbjct: 519 NEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPA 578
Query: 723 PQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGINV 782
PQI+ HSPKYTC+CP + + + C A +E +T +A G+
Sbjct: 579 PQISSHSPKYTCACPDTMWLGPDMKRCYRDA-----NEDSKMGSTVTAAVIGI------- 626
Query: 783 TTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTE 842
I+P++++ + + GYL+WRNW+ KN KSMNFDNPVY KTTE
Sbjct: 627 -------------------IVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTE 667
Query: 843 E--DLSIDIGRHSASVGHTYPAISVVSTDDD 871
E + + IGR +A +GH YPA +S +DD
Sbjct: 668 EEDEDELHIGR-TAQIGHVYPARVALSLEDD 697
Score = 209 bits (533), Expect = 7e-54
Identities = 101/218 (46%), Positives = 123/218 (56%), Gaps = 14/218 (6%)
Query: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
Query: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
Query: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNI--TCSPDEFTCSSGRCISRNFVCNGQ 176
SCG S +C+P SWRCDGE DC+ G DE C TC DEF C G C+ CN +
Sbjct: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQE 192
Query: 177 DDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDD 214
DC DGSDE C G +E + C S +C D
Sbjct: 193 QDCPDGSDEAGCLQ---GLNECLHNNGGC---SHICTD 224
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 655 bits (1690), Expect = 0.0
Identities = 320/677 (47%), Positives = 441/677 (65%), Gaps = 54/677 (7%)
Query: 239 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCN 298
C + QC + CI WRCD D DC D SDE +CP +TC F C++G CIH +C+
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106
Query: 299 GIRDCVDGSDEVNCKNVNQCLGPGKFKC--RSGECIDISKVCNQEQDCRDWSDEPLKECH 356
G +C DGSDE Q K C S +C+ S C+ E+DC +DE
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATW 166
Query: 357 INECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGG 416
+NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P CSQIC+N KG
Sbjct: 167 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGY 226
Query: 417 YKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD 475
+KCEC GY+MDL T CKA GK PSLIFTNR ++R+I L ++ Y +L+ L+N VALD
Sbjct: 227 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 286
Query: 476 ADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
++A +++W DLS + I+SA +D D + V + + +++P +AVDWV+K IYWTD+
Sbjct: 287 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 346
Query: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
+KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+NG DR+
Sbjct: 347 GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQ 406
Query: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652
LV+ +I+WPNGITLDL+ RLYW+DSKLH LSS+D +G +R+ ++ S +FL+HP + +
Sbjct: 407 TLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV 466
Query: 653 FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDME- 711
FED+V+W D ENEA++ AN+ G E++ L NLN+ DI+++HEL QP + CE ++
Sbjct: 467 FEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQP 526
Query: 712 NGGCEYLCLPAPQINDHSPKYTCSCPS----GYNVEENGRDCQSTAT------------- 754
NGGCEYLCLPAPQI+ HSPKYTC+CP G +++ R QST+T
Sbjct: 527 NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPA 586
Query: 755 ------TVTYSETKDTNTTEISATSGLVPGGINVTTA--VSEVSVPP------------- 793
T + T ++TE + + VP ++V A +S ++ P
Sbjct: 587 TTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQHYANED 646
Query: 794 --KGTSAAWA----ILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEE--DL 845
G++ A I+P++++ + + GYL+WRNW+ KN KSMNFDNPVY KTTEE +
Sbjct: 647 SKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDED 706
Query: 846 SIDIGRHSASVGHTYPA 862
+ IGR +A +GH YPA
Sbjct: 707 ELHIGR-TAQIGHVYPA 722
Score = 177 bits (450), Expect = 3e-44
Identities = 88/200 (44%), Positives = 108/200 (54%), Gaps = 23/200 (11%)
Query: 5 ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
AL L LLL L + A G G CE QFQC N RCI +W+CD D+DC
Sbjct: 13 ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72
Query: 59 VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
+D SDE +C KKTCA+SDF C+NG C+ RWKCDG+ +C DGSDES C + C ++
Sbjct: 73 LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132
Query: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENC---------GNITCS--------PDEFTC 161
SCG S +C+P SWRCDGE DC+ G DE C N CS E TC
Sbjct: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTC 192
Query: 162 SSGRCISRNFVCNGQDDCSD 181
+G + C D+C D
Sbjct: 193 PAGFQLLDQKTCGDIDECKD 212
Score = 109 bits (272), Expect = 1e-23
Identities = 65/210 (30%), Positives = 94/210 (44%), Gaps = 31/210 (14%)
Query: 111 RTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRN 170
+ C + C + +CIP WRCD ++DC DE++C TC+ +FTC +G CI
Sbjct: 45 KDCEKDQFQC--RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER 102
Query: 171 FVCNGQDDCSDGSDELD--CAPPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESL 226
+ C+G+++C DGSDE + C C A + C +S C+P SW CD + DC +DE+
Sbjct: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA- 161
Query: 227 EQCGRQPVIHTKCPASEIQCGS--GECIHKKWRCDG-DPDCKDGSDEVNCPSRTCRPDQF 283
C + EC+H C D K G E CP+ DQ
Sbjct: 162 ------------------GCATWLNECLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQK 202
Query: 284 ECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
C D C+ I CV+ C+
Sbjct: 203 TCGDIDECKDPDACSQI--CVNYKGYFKCE 230
>gi|157384998 low density lipoprotein receptor-related protein 4
[Homo sapiens]
Length = 1905
Score = 603 bits (1554), Expect = e-172
Identities = 315/777 (40%), Positives = 426/777 (54%), Gaps = 50/777 (6%)
Query: 7 WALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGR-----CITLLWKCDGDEDCVDG 61
W LL AL A + + C S F C CI W+CDGD DC D
Sbjct: 5 WGALLLGALLCAH----GLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH 60
Query: 62 SDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCG 121
SDE C+ TC+ DF C+NG+C+ W CDGD DCED SDE + C R C E C
Sbjct: 61 SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE--QDCPPRECEEDEFPC- 117
Query: 122 AHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSD 181
+ CI W CDG+NDC DE+ C CS EF CS G CI+ ++ C+G DC D
Sbjct: 118 -QNGYCIRSLWHCDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKD 175
Query: 182 GSDELDC-----APPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH 236
GSDE +C APP C EFQC+ CI + CD D DC D SDES C H
Sbjct: 176 GSDEENCPSAVPAPP-CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDES--DCSS----H 228
Query: 237 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQ 296
C + E C SG CI+ WRCDGD DC D SDE NC + C +QF C G C+ S +
Sbjct: 229 QPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWR 288
Query: 297 CNGIRDCVDGSDEVNCKNVN--QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE-PLK 353
C+G DC D SDE NC+N QC +F C +G CI K+CN DC D SDE P +
Sbjct: 289 CDGEDDCADNSDEENCENTGSPQC-ALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347
Query: 354 ECHIN----ECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQ 408
C C VNNGGC+ C+ + +C C G+ L D TC D++EC G CSQ
Sbjct: 348 NCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQ 407
Query: 409 ICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL 468
C N +G ++C C GY++ CKA+G EP L+F NR DIR++ R EY L+ L
Sbjct: 408 GCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNL 467
Query: 469 RNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKT 526
N +ALD + +FW+D++ I A+++ G +V+ + + +P +AVDWV+
Sbjct: 468 ENAIALDFHHRRELVFWSDVTLDRILRANLN---GSNVEEVVSTGLESPGGLAVDWVHDK 524
Query: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586
+YWTD+ + I VA LDG RK L +L +P +IA+ P+ G +YW+DWG +IE + M
Sbjct: 525 LYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSM 584
Query: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
+G RR + + WPNG+T+D R+YW+D+K H++ +L+G R+ V+ + L H
Sbjct: 585 DGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVIS--QGLPH 642
Query: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWC 706
P A+T+FED +YW D +++ ANKFTG + N L+ DI H QP+GKN C
Sbjct: 643 PFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRC 702
Query: 707 EEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKD 763
++ NGGC +LCLP+ Q YTC+CP+G+ + QS + ++ D
Sbjct: 703 GDN--NGGCTHLCLPSGQ------NYTCACPTGFRKISSHACAQSLDKFLLFARRMD 751
Score = 239 bits (609), Expect = 1e-62
Identities = 125/362 (34%), Positives = 203/362 (56%), Gaps = 20/362 (5%)
Query: 391 RKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD 450
+ CGD N G C+ +C+ Y C C G++ +++ C A + L+F R D
Sbjct: 699 KNRCGD-----NNGGCTHLCLPSGQNYTCACPTGFRK-ISSHAC-AQSLDKFLLFARRMD 751
Query: 451 IRKIGLERKEYIQLVEQL---RNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK 507
IR+I + ++ V L R+ VALD D ++W D+S I A D G+ V
Sbjct: 752 IRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDG-TGQEVV 810
Query: 508 MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLS 567
+ ++ +PA +A+DWV +YWTDA + I VA DG+ R L +L P I V+P+
Sbjct: 811 VDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMG 870
Query: 568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
G++YW+DWG KIE+AGM+ R+ ++++++ WPNG+ +D RLYW D+ + +
Sbjct: 871 GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFA 930
Query: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
L+G R++++ S L HP LT++ +R+YW D + +++ A++ TG + TL NL +
Sbjct: 931 GLDGSKRKVLIGSQ--LPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLEN 988
Query: 688 AQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR 747
DI V+H +P C MENGGC +LCL +P + ++C+CP+G N+ +G+
Sbjct: 989 LMDIHVFHRR-RPPVSTPCA--MENGGCSHLCLRSP----NPSGFSCTCPTGINLLSDGK 1041
Query: 748 DC 749
C
Sbjct: 1042 TC 1043
Score = 234 bits (597), Expect = 3e-61
Identities = 148/499 (29%), Positives = 248/499 (49%), Gaps = 65/499 (13%)
Query: 387 ELIDRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIF 445
+ +DR ++C G CS +C+ G+ C C G Q+ C E L+F
Sbjct: 1300 QAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDP-SPETYLLF 1358
Query: 446 TNRRDIRKIGLERKEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK- 501
++R IR+I L+ ++ + V +L N ++LD D K+++ D+ I A ++
Sbjct: 1359 SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN 1418
Query: 502 ----VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLRE 557
+GR +K D +AVDWV + +YWTD TI + LDG+ RK L N+ L E
Sbjct: 1419 METVIGRGLKTTDG------LAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDE 1472
Query: 558 PASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWL 617
P +IAV P G+++W+DWG AKIE+A ++G +R+ L+ D+ WPNG+TLD R+YW+
Sbjct: 1473 PRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWV 1532
Query: 618 DSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSE 677
D+ L + S DLNG+ R+++ + ++HP ALT + +YW D + +++ +K++G
Sbjct: 1533 DAHLDRIESADLNGKLRQVL---VSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRN 1589
Query: 678 LATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
T++ N+ DIIV Q +G N C + NGGC +LC + + C+CP
Sbjct: 1590 KETVLANVEGLMDIIVVSPQRQ-TGTNAC--GVNNGGCTHLCFA------RASDFVCACP 1640
Query: 738 SGYNVEENGRDCQ-----------------------STATTVTYSETKDTNTT--EISAT 772
E + R C +T T YS T T T+ E+
Sbjct: 1641 D----EPDSRPCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGR 1696
Query: 773 SGLVPGGINVTTAVSEV--SVPPKGTSAAWAILPLL--LLVMAAVGGYLMWRNWQHK--- 825
+ + ++ + P +G ++AI LL LL++ + +++R+ + K
Sbjct: 1697 CSERDARLGLCARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTD 1756
Query: 826 -NMKSMNFDNPVYLKTTEE 843
M ++ + NP Y +T+E
Sbjct: 1757 PGMGNLTYSNPSYRTSTQE 1775
Score = 216 bits (549), Expect = 1e-55
Identities = 125/403 (31%), Positives = 200/403 (49%), Gaps = 61/403 (15%)
Query: 360 CLVNNGGCSHIC--KDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
C + NGGCSH+C G+ C C G L+ D KTC +PG+ S
Sbjct: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC-------SPGMNS--------- 1049
Query: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVE----QLRNTV 472
LIF R DIR + L+ + +V ++NT+
Sbjct: 1050 -------------------------FLIFARRIDIRMVSLDIPYFADVVVPINITMKNTI 1084
Query: 473 ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
A+ D K++W+D + I A++D + + + +AVD + + +YWTD
Sbjct: 1085 AIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDI-ITTGLQTTDGLAVDAIGRKVYWTDT 1143
Query: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
+ I V LDG+ RK L +L P +I + GF+YW+DWGE AK+E++GM+G DR
Sbjct: 1144 GTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRA 1203
Query: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652
L+ ++ WPNG+T+D S+L W D+ + + DLNG +R ++ ++ HP LT+
Sbjct: 1204 VLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQ---HPYGLTL 1260
Query: 653 FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMEN 712
+ +YW D + +++ A+K TGS + + +NL D+ + QP G N C N
Sbjct: 1261 LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-DRAQPLGFNKC--GSRN 1317
Query: 713 GGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
GGC +LCLP P ++C+CP+G ++ +G+ C + T
Sbjct: 1318 GGCSHLCLPRPS------GFSCACPTGIQLKGDGKTCDPSPET 1354
Score = 35.0 bits (79), Expect = 0.30
Identities = 13/32 (40%), Positives = 18/32 (56%)
Query: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDC 382
P ++ N C VNNGGC+H+C + C C
Sbjct: 1608 PQRQTGTNACGVNNGGCTHLCFARASDFVCAC 1639
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 542 bits (1397), Expect = e-154
Identities = 303/788 (38%), Positives = 426/788 (54%), Gaps = 82/788 (10%)
Query: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKC 91
+C+ + QC+NGRC++ + C+G +DC DGSDE C K C +F C +G C+ + +C
Sbjct: 2565 RCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRC 2624
Query: 92 DGDPDCEDGSDE---SPEQCHM---------------RTCRIHEIS--------CGAHST 125
+ DCED SDE S C RT + S CG +S
Sbjct: 2625 NQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSD 2684
Query: 126 Q----------------------CIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSS 163
+ CIP+SW CD E+DC+ GEDE +C N CS +F C +
Sbjct: 2685 ERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQN 2743
Query: 164 GRCISRNFVCNGQDDCSDGSDEL-DCAPPTCGAHEFQC-STSSCIPISWVCDDDADCSDQ 221
RCIS+ ++C+G DDC DGSDE C TCG F C T C+P W+CD D DC+D
Sbjct: 2744 HRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADG 2803
Query: 222 SDESLEQ-CGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV-NCPSRTCR 279
+DES+ C + ++ C E C + +CI K + CD D DC DGSDE C TC
Sbjct: 2804 ADESIAAGC----LYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCG 2859
Query: 280 PDQFECEDGSCIHGSR-QCNGIRDCVDGSDEV----NCKNV-NQCLGPGKFKCRSGECID 333
P +F C +G C+ + +C+G DC D SDE +C + ++C +F C SG C+
Sbjct: 2860 PSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVA 2919
Query: 334 ISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHICKDLVIGYECDCAAGFELIDR- 391
+ +CN + DC D SDE + CHINECL GCS C+DL IG++C C GF L D
Sbjct: 2920 EALLCNGQDDCGDSSDE--RGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDG 2977
Query: 392 KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATG-VCKAV-GKEPSLIFTNRR 449
+TC D+DEC CSQ CIN G YKC C GY CKAV +EP LIF NR
Sbjct: 2978 RTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRY 3037
Query: 450 DIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI 509
+RK+ L+ Y L + L N VALD D Q ++W D++ + + G +V+++
Sbjct: 3038 YLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN-GSNVQVL 3096
Query: 510 DN--VYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLS 567
+ NP +AVDWV +YW D TI V+ L+G R L +S LREP ++ VD +
Sbjct: 3097 HRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQN 3156
Query: 568 GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
G++YW+DWG+ + I + GM+G R +V I WPNG+TLD + R+YW D++ +
Sbjct: 3157 GYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFA 3216
Query: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
L+G +R +VL + + H ALT+FED VYW D E +++ A+K TG+ L++ L+
Sbjct: 3217 SLDGSNRHVVLS--QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHR 3274
Query: 688 AQDIIVYHELVQPSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENG 746
D+ V+H L QP N C+ + NGGC LCL +P + C+CP+ + + +G
Sbjct: 3275 PMDLHVFHALRQPDVPNHPCK--VNNGGCSNLCLLSP-----GGGHKCACPTNFYLGSDG 3327
Query: 747 RDCQSTAT 754
R C S T
Sbjct: 3328 RTCVSNCT 3335
Score = 538 bits (1386), Expect = e-153
Identities = 292/748 (39%), Positives = 410/748 (54%), Gaps = 59/748 (7%)
Query: 33 CEPSQFQCT-NGRCITLLWKCDGDEDCVDGSDEK-NCVKKTCAESDFVC-NNGQCVPSRW 89
C P+QFQC+ RCI +W CD D DCVDGSDE NC + TC +F C ++G+C+P+RW
Sbjct: 3453 CAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARW 3512
Query: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
KCDG+ DC DGSDE E+C RTC ++ C + +C+P W+CD +NDC DEE+C
Sbjct: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRC--KNNRCVPGRWQCDYDNDCGDNSDEESC 3570
Query: 150 GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPIS 209
CS EF+C++GRCI+ + C+G DC+DGSDE DC P C +FQC + CIP+
Sbjct: 3571 TPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP-RCDMDQFQCKSGHCIPLR 3629
Query: 210 WVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSD 269
W CD DADC D SDE E CG + T CP E QC + C W+CDG+ DC D SD
Sbjct: 3630 WRCDADADCMDGSDE--EACGTG--VRT-CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSD 3684
Query: 270 E--VNCPSRTCRPDQ-FECE-DGSCIHGSRQCNGIRDCVDGSDEVNCK----NVNQCLGP 321
E C C P++ F C+ D C+ RQC+G +C DG+DE +C+ + C
Sbjct: 3685 ENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDK 3744
Query: 322 GKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYE-- 379
+F CR+ C+ S CN DC D SDE ++C I+ L + + IC D
Sbjct: 3745 KEFLCRNQRCLSSSLRCNMFDDCGDGSDE--EDCSIDPKLTSCATNASICGDEARCVRTE 3802
Query: 380 ----CDCAAGFELIDRKT-CGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVC 434
C C +GF + + C DI+EC G CSQ+C N KGG+ C C+R + T C
Sbjct: 3803 KAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNT--C 3860
Query: 435 KAVGKEPSLIF-TNRRDIRKI--GLERKEYIQLVE--QLRNTVALDADIAAQKLFWAD-- 487
KA G E +++ + +IR + G Y Q + + A+D + A +++W +
Sbjct: 3861 KAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWH 3920
Query: 488 ---LSQKAIFSASIDDKVGRHVKMIDN---------VYNPAAIAVDWVYKTIYWTDAASK 535
+S +++ A+ RH + ID + P IA+DWV +YWTD+
Sbjct: 3921 TGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRD 3980
Query: 536 TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLV 595
I VA + G RK L + + EP +I VDPL G +YWSDWG KIE A M+G R LV
Sbjct: 3981 VIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLV 4040
Query: 596 TADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFED 655
+IQWP G+ +D RLYW D+KL ++ S+ LNG D + S L+HP ++ +FED
Sbjct: 4041 QDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFED 4100
Query: 656 RVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGC 715
+Y + N V+ +KF S L L L+ A D+++YH+ QP N C+ C
Sbjct: 4101 YIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKK----C 4156
Query: 716 EYLCLPAPQINDHSPKYTCSCPSGYNVE 743
E+LCL +P P C+CP+G ++
Sbjct: 4157 EWLCLLSPS----GP--VCTCPNGKRLD 4178
Score = 523 bits (1347), Expect = e-148
Identities = 285/761 (37%), Positives = 404/761 (53%), Gaps = 34/761 (4%)
Query: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKN--CVKKTCAESDFVCNNGQCVPSRW 89
+C+P +F C N RCI WKCDGD DC+D SDE C + TC F C N +C+P+RW
Sbjct: 853 QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRW 912
Query: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEE-N 148
CDGD DC + DES C RTC ++ SC S +CIP+SW CD ++DC DE +
Sbjct: 913 LCDGDNDCGNSEDESNATCSARTCPPNQFSCA--SGRCIPISWTCDLDDDCGDRSDESAS 970
Query: 149 CGNITCSP-DEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIP 207
C TC P +FTC++GRCI+ N+ C+ +DC D SDE C+ +C + +F+C++ CIP
Sbjct: 971 CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSH-SCSSTQFKCNSGRCIP 1029
Query: 208 ISWVCDDDADCSDQSDESLEQCGRQPVIHTK-CPASEIQCG-SGECIHKKWRCDGDPDCK 265
W CD D DC D SDE+ C Q C E QC G CI +WRCDGD DC
Sbjct: 1030 EHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCM 1089
Query: 266 DGSDEVNCPSRT--CRPD-QFECEDGS-CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 321
D SDE +C T C P +F C+D + CI + C+G DC D SDE NC+++ P
Sbjct: 1090 DSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESL--ACRP 1147
Query: 322 GKFKCRSGE--CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV-IGY 378
C + C+ K+C+ DC D SDE + C ++C +NNGGCSH C G
Sbjct: 1148 PSHPCANNTSVCLPPDKLCDGNDDCGDGSDEG-ELC--DQCSLNNGGCSHNCSVAPGEGI 1204
Query: 379 ECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
C C G EL D TC C CSQ C K KC C G+ ++ C+++
Sbjct: 1205 VCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSL 1264
Query: 438 GK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSA 496
+P +IF+NR +IR+I L + +Y LV LRNT+ALD ++ L+W D+ + I+
Sbjct: 1265 DPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRG 1324
Query: 497 SIDDK---VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNS 553
+ D V + + P +AVDW+ IYW ++ I VA LDGT R L
Sbjct: 1325 KLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAG 1384
Query: 554 DLREPASIAVDPLSGFVYWSDWGEPA-KIEKAGMNGFDRRPL--VTADIQWPNGITLDLI 610
D+ P +IA+DP G ++W+DW +IE A M+G RR + T WPNG+T+D +
Sbjct: 1385 DIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYL 1444
Query: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGA 670
+ R+ W+D++ + S +G VL+ EFL+HP A+T++ VYW D + A
Sbjct: 1445 EKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKA 1504
Query: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSP 730
NK+TG + + D+ VYH QP N CE + G C +LCL IN ++
Sbjct: 1505 NKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCL----IN-YNR 1559
Query: 731 KYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISA 771
+C+CP + ++ C + Y+ + ++ A
Sbjct: 1560 TVSCACPHLMKLHKDNTTCYEFKKFLLYARQMEIRGVDLDA 1600
Score = 302 bits (773), Expect = 1e-81
Identities = 156/423 (36%), Positives = 228/423 (53%), Gaps = 36/423 (8%)
Query: 23 GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNN 81
G+ G + C SQF C N +CI WKCD ++DC D SDE +C + C F C+
Sbjct: 3324 GSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCST 3383
Query: 82 GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
G C + CDGD DC+D SDE+ C + C + C ++ +CIP +RC+G+++C
Sbjct: 3384 GICTNPAFICDGDNDCQDNSDEA--NCDIHVCLPSQFKC-TNTNRCIPGIFRCNGQDNCG 3440
Query: 142 SGEDEENCGNITCSPDEFTCS-SGRCISRNFVCNGQDDCSDGSDE-LDCAPPTCGAHEFQ 199
GEDE +C +TC+P++F CS + RCI R +VC+ +DC DGSDE +C TCG EF+
Sbjct: 3441 DGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 3500
Query: 200 CSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRC 258
C S CIP W CD + DC D SDE E+C + C + +C + C+ +W+C
Sbjct: 3501 CKDSGRCIPARWKCDGEDDCGDGSDEPKEECDER-----TCEPYQFRCKNNRCVPGRWQC 3555
Query: 259 DGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQC 318
D D DC D SDE +C R C +F C +G CI G +C+G DC DGSDE +C +C
Sbjct: 3556 DYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC--TPRC 3613
Query: 319 LGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSH-ICKDLVIG 377
+F+C+SG CI + C+ + DC D SDE + C ++ C++ +CK L
Sbjct: 3614 -DMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPL--A 3670
Query: 378 YECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
++CD CGD + +NP C++ ++C+ R VC +
Sbjct: 3671 WKCD--------GEDDCGDNSD-ENPEECARFVCPPNRPFRCKNDR---------VCLWI 3712
Query: 438 GKE 440
G++
Sbjct: 3713 GRQ 3715
Score = 298 bits (762), Expect = 2e-80
Identities = 160/392 (40%), Positives = 208/392 (53%), Gaps = 28/392 (7%)
Query: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVC-NNGQCVPSRWK 90
KC P QFQC+ G C + CDGD DC D SDE NC C S F C N +C+P ++
Sbjct: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFR 3432
Query: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENC 149
C+G +C DG DE C TC ++ C + +CIP W CD +NDC G DE NC
Sbjct: 3433 CNGQDNCGDGEDE--RDCPEVTCAPNQFQCSI-TKRCIPRVWVCDRDNDCVDGSDEPANC 3489
Query: 150 GNITCSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCI 206
+TC DEF C SGRCI + C+G+DDC DGSDE +C TC ++F+C + C+
Sbjct: 3490 TQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCV 3549
Query: 207 PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKD 266
P W CD D DC D SDE E C +P C SE C +G CI +W+CDGD DC D
Sbjct: 3550 PGRWQCDYDNDCGDNSDE--ESCTPRP-----CSESEFSCANGRCIAGRWKCDGDHDCAD 3602
Query: 267 GSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKC 326
GSDE +C R C DQF+C+ G CI +C+ DC+DGSDE C + +F+C
Sbjct: 3603 GSDEKDCTPR-CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQC 3661
Query: 327 RSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNG-GCSHICKDLVIGYECDCAAG 385
+ C ++ C+ E DC D SDE +EC C N C + L IG +CD
Sbjct: 3662 NNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCD---- 3717
Query: 386 FELIDRKTCG---DIDECQNPGICSQICINLK 414
CG D ++C+ P + C + K
Sbjct: 3718 ----GTDNCGDGTDEEDCEPPTAHTTHCKDKK 3745
Score = 243 bits (620), Expect = 6e-64
Identities = 158/503 (31%), Positives = 250/503 (49%), Gaps = 35/503 (6%)
Query: 276 RTCRPDQFECEDG-SCIHGSRQCNGIRDCVDGSDE---VNCKNVNQCLGPGKFKCRSGE- 330
+TC P QF C D +CI +C+G RDC DGSDE + ++ Q P + C E
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTEL 84
Query: 331 CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFEL-I 389
C+ +S++CN QDC D SDE C + + GC H C + G C C + F+L
Sbjct: 85 CVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQA 143
Query: 390 DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKA----VGKEPSLIF 445
D KTC D DEC G CSQ+C N G + C C GY + CKA V + P L+
Sbjct: 144 DGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLI 203
Query: 446 TNRRDIRKIGLERKEYIQLVE-QLRNTVALDADIAAQKLFWADLSQKAIFSA-------S 497
N ++I L + + R T A+D A + + W + A +
Sbjct: 204 ANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPG 263
Query: 498 IDDKVGRHVKMID-NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR 556
+ V H I ++++ +A+DW+ Y+ D I V +G L + +L
Sbjct: 264 LKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELY 323
Query: 557 EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616
P IA+DP G V+++D+G+ K+E+ M+G +R LV + I +P+GITLDL+ +YW
Sbjct: 324 NPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYW 383
Query: 617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGEN------EAVYGA 670
D+ L + VD G+ R+ +++ + + H LT+FE+ +Y + +N +V
Sbjct: 384 ADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV 442
Query: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW-CEEDM--ENGGCEYLCLPAPQIND 727
N+F +E +V ++ + +YH+ QP ++ CE D + GGC +CL A N
Sbjct: 443 NRFNSTEY-QVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLA---NS 498
Query: 728 HSPKYTCSCPSGYNVEENGRDCQ 750
H + TC C SG+++ +G+ C+
Sbjct: 499 HKAR-TCRCRSGFSLGSDGKSCK 520
Score = 216 bits (551), Expect = 6e-56
Identities = 143/424 (33%), Positives = 194/424 (45%), Gaps = 49/424 (11%)
Query: 33 CEPSQFQCTNGRCITL-LWKCDGDEDCVDGS-----DEKNC--VKKTC-AESDFVCNNGQ 83
CE S + NG C L L G +C D+ C V +C A+ +F C NG+
Sbjct: 2477 CELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGE 2536
Query: 84 CVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSG 143
C+ CDG P C+D SDE P C+ R C+ C + +C+ C+G +DC G
Sbjct: 2537 CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCS--NGRCVSNMLWCNGADDCGDG 2594
Query: 144 EDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAH------- 196
DE C C EF C G CI + CN DC D SDE++C+ C ++
Sbjct: 2595 SDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKG 2654
Query: 197 -EFQ-CS-TSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIH 253
FQ C TS C SWVCD DC D SDE C V +CP + C SG CI
Sbjct: 2655 VLFQPCERTSLCYAPSWVCDGANDCGDYSDE--RDC--PGVKRPRCPLNYFACPSGRCIP 2710
Query: 254 KKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE-VNC 312
W CD + DC+ G DE +C ++ C QFEC++ CI C+G DC DGSDE +C
Sbjct: 2711 MSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHC 2769
Query: 313 KNVNQCLGPGKFKCRSGE-CIDISKVCNQEQDCRDWSDEPL-------KECHINECLVNN 364
+ + GP F C C+ +C+ ++DC D +DE + C E + N
Sbjct: 2770 E--GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQN 2827
Query: 365 GGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRG 424
C I K V ++ DCA G + + EC+ P C G +C SR
Sbjct: 2828 RQC--IPKHFVCDHDRDCADGSD--------ESPECEYP-TCGPSEFRCANG-RCLSSRQ 2875
Query: 425 YQMD 428
++ D
Sbjct: 2876 WECD 2879
Score = 213 bits (541), Expect = 8e-55
Identities = 173/611 (28%), Positives = 254/611 (41%), Gaps = 86/611 (14%)
Query: 21 ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVC 79
E G T C +QF+C N RCI+ W CDG +DC DGSDE +C KTC S F C
Sbjct: 2722 EHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSC 2781
Query: 80 -NNGQCVPSRWKCDGDPDCEDGSDESPEQ--CHMRTCRIHEISCGAHSTQCIPVSWRCDG 136
CVP RW CDGD DC DG+DES + TC E C + QCIP + CD
Sbjct: 2782 PGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMC--QNRQCIPKHFVCDH 2839
Query: 137 ENDCDSGEDEE-NCGNITCSPDEFTCSSGRCI-SRNFVCNGQDDCSDGSDELDCAP--PT 192
+ DC G DE C TC P EF C++GRC+ SR + C+G++DC D SDE AP P
Sbjct: 2840 DRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE---APKNPH 2896
Query: 193 CGAHEFQCSTSS--------CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEI 244
C + E +C+ SS C+ + +C+ DC D SDE
Sbjct: 2897 CTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDER------------------- 2937
Query: 245 QCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCV 304
C EC+ +K DC+D C CRP +DG +C+ C
Sbjct: 2938 GCHINECLSRK-LSGCSQDCEDLKIGFKC---RCRPGFRLKDDGRTCADVDECSTTFPCS 2993
Query: 305 DGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHI---NECL 361
+N +CL + R G+ V ++E + L++ ++ N L
Sbjct: 2994 QRC--INTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTL 3051
Query: 362 VNNGGCSHICKDL----VIGYECDCAAGFELIDRK--TCGDIDECQNPGICSQ--ICINL 413
+ G + + D + Y D +I R ++ G+ + + ++
Sbjct: 3052 LKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDW 3111
Query: 414 KGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEY--IQLVEQLRNT 471
GG C +G RD ++ Y + + LR
Sbjct: 3112 VGGNLYWCDKG------------------------RDTIEVSKLNGAYRTVLVSSGLREP 3147
Query: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
AL D+ L+W D ++ D R V + + P + +D+V + IYW D
Sbjct: 3148 RALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWAD 3207
Query: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
A I A+LDG+ R + + D+ P A+ +VYW+DW E I +A
Sbjct: 3208 AREDYIEFASLDGSNRHVVLSQDI--PHIFALTLFEDYVYWTDW-ETKSINRAHKTTGTN 3264
Query: 592 RPLVTADIQWP 602
+ L+ + + P
Sbjct: 3265 KTLLISTLHRP 3275
Score = 167 bits (424), Expect = 3e-41
Identities = 109/367 (29%), Positives = 182/367 (49%), Gaps = 22/367 (5%)
Query: 402 NPGICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
N G CSQ+C+ + C C+ GY + C+ VG L+++ IR I L+ +
Sbjct: 1853 NNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYSVHEGIRGIPLDPND 1910
Query: 461 YIQLVEQLRNT---VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAA 517
+ + T V +D ++W D+ I A D+ R + + +
Sbjct: 1911 KSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAK-RDQTWREDVVTNGIGRVEG 1969
Query: 518 IAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGE 577
IAVDW+ IYWTD I VA L+G+ R + + L +P +I V P G+++W++WG+
Sbjct: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029
Query: 578 PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL-NGQDRRI 636
+IE++ ++G +R LV I WPNGI++D +LYW D++ + +DL G++R +
Sbjct: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089
Query: 637 VLKSLEFLAHPLALTIFEDRVYWID--GENEAVYGANKFTGSELATLVNNLN-DAQDIIV 693
VL S ++++FED +YW D N ++ +K ++ L + +DI V
Sbjct: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147
Query: 694 YHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTA 753
++ Q G N C + NGGC+ LCL + + C+C G + E+G C+ A
Sbjct: 2148 FNRDRQ-KGTNVCA--VANGGCQQLCLYRGR-----GQRACACAHGM-LAEDGASCREYA 2198
Query: 754 TTVTYSE 760
+ YSE
Sbjct: 2199 GYLLYSE 2205
Score = 164 bits (416), Expect = 3e-40
Identities = 118/379 (31%), Positives = 180/379 (47%), Gaps = 30/379 (7%)
Query: 398 DECQNPGICSQICI--NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD--IRK 453
D+ PG CS IC+ N C C G+ + CK E L++ R IR
Sbjct: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540
Query: 454 IGLERK---EYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMID 510
+ + K E++ +E L N ALD +++AD + I ID R + D
Sbjct: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDG-TERETILKD 599
Query: 511 NVYNPAAIAVDWVYKTIYWTD-AASKTISVATLD--GTKRKFLFNSDLREPASIAVDPLS 567
++N +AVDW+ +YWTD KTISVA L+ RK L + P +I VDPL+
Sbjct: 600 GIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLN 659
Query: 568 GFVYWSDWGEPAK------IEKAGMNGFDRRPLVTAD-IQWPNGITLDLIKSRLYWLDSK 620
G++YW+DW E K +E+A M+G R VT+ + WPNG++LD+ RLYW+D+
Sbjct: 660 GWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAF 719
Query: 621 LHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELAT 680
+ ++ LNG DR+IV + E L H L + ++W + + +VY + G T
Sbjct: 720 YDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPT 778
Query: 681 LVNNLNDAQ---DIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
+ ++ +I +Y Q G N C + NGGC LCL P C+C
Sbjct: 779 VTLLRSERPPIFEIRMYDAQQQQVGTNKCR--VNNGGCSSLCLATPGSRQ------CACA 830
Query: 738 SGYNVEENGRDCQSTATTV 756
++ +G C + + V
Sbjct: 831 EDQVLDADGVTCLANPSYV 849
Score = 150 bits (378), Expect = 6e-36
Identities = 101/363 (27%), Positives = 169/363 (46%), Gaps = 20/363 (5%)
Query: 404 GICSQIC-INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
G CS +C IN C C ++ C K L++ + +IR + L+ Y
Sbjct: 1547 GPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKK--FLLYARQMEIRGVDLDAPYYN 1604
Query: 463 QLVE----QLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
++ + N LD D Q+++W+D+ +AI A I+ G + ++ N +
Sbjct: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING-TGVETVVSADLPNAHGL 1663
Query: 519 AVDWVYKTIYWT--DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG 576
AVDWV + ++WT D K I+VA LDG+ + + L +P + V PL G +YW+D
Sbjct: 1664 AVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQG-LEQPHGLVVHPLRGKLYWTDGD 1722
Query: 577 EPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRI 636
I A M+G +R L + + P G+ +D +S+LYW+ S H ++ +L+G +
Sbjct: 1723 N---ISMANMDGSNRTLLFSGQ-KGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEV 1778
Query: 637 VLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHE 696
+ L AL I D+++W D +E + +K GS L N+ + VY E
Sbjct: 1779 IDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDE 1838
Query: 697 LVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTV 756
+Q K + NG C LCLP + +C C +GY++ + C+ + +
Sbjct: 1839 SIQLDHKGTNPCSVNNGDCSQLCLPTSETT-----RSCMCTAGYSLRSGQQACEGVGSFL 1893
Query: 757 TYS 759
YS
Sbjct: 1894 LYS 1896
Score = 147 bits (371), Expect = 4e-35
Identities = 93/268 (34%), Positives = 123/268 (45%), Gaps = 39/268 (14%)
Query: 146 EENCGNITCSPDEFTCSSGRCI----SRNFVCNGQDDCSDGSDELDCA-------PPTCG 194
++ G C + CSS C+ SR C +D D +D + C PP C
Sbjct: 799 QQQVGTNKCRVNNGGCSS-LCLATPGSRQCAC-AEDQVLD-ADGVTCLANPSYVPPPQCQ 855
Query: 195 AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHK 254
EF C+ S CI W CD D DC D SDE+ C + HT CP+ +C + CI
Sbjct: 856 PGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ----HT-CPSDRFKCENNRCIPN 910
Query: 255 KWRCDGDPDCKDGSDEVN--CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
+W CDGD DC + DE N C +RTC P+QF C G CI S C+ DC D SDE
Sbjct: 911 RWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESAS 970
Query: 313 KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICK 372
C +F C +G CI+I+ C+ + DC D SDE GCSH C
Sbjct: 971 CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDE--------------AGCSHSCS 1016
Query: 373 DLVIGYECDCAAGFELIDRKTCGDIDEC 400
+ C +G + + TC ++C
Sbjct: 1017 ST----QFKCNSGRCIPEHWTCDGDNDC 1040
Score = 119 bits (298), Expect = 1e-26
Identities = 91/367 (24%), Positives = 164/367 (44%), Gaps = 41/367 (11%)
Query: 404 GICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
G C Q+C+ G + C C+ G + + G L+++ R ++ I L + +
Sbjct: 2164 GGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGY---LLYSERTILKSIHLSDERNL 2220
Query: 463 QLV-------EQLRNTVALDADIAA-------QKLFWADLSQKAIFSASIDDKVGRHVKM 508
E ++N +AL D A ++F++D+ I I+D R + +
Sbjct: 2221 NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI--QQINDDGSRRITI 2278
Query: 509 IDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK------RKFLFNSDLREPASIA 562
++NV + +A + T+YWT + TI+ T+D T+ + S P +
Sbjct: 2279 VENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFV 2338
Query: 563 VDPLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKL 621
+D ++W++W E I +A ++G + L+ DI+ PNG+ +D +LY+ D+ L
Sbjct: 2339 LDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATL 2398
Query: 622 HMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATL 681
+ + +G R ++LKS HP L ++ + ++W D AV ANK GS + L
Sbjct: 2399 DKIERCEYDGSHRYVILKSEP--VHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLL 2456
Query: 682 VNNLNDAQDIIVYHELVQPSGKNWCEED---MENGGCEYLCLPAPQINDHSPKYTCSCPS 738
++ I+ + N CE + NGGC+ LCL H CSC
Sbjct: 2457 RVDIPQQPMGII----AVANDTNSCELSPCRINNGGCQDLCLLT-----HQGHVNCSCRG 2507
Query: 739 GYNVEEN 745
G ++++
Sbjct: 2508 GRILQDD 2514
Score = 73.9 bits (180), Expect = 6e-13
Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 22/132 (16%)
Query: 70 KTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQC---HMRTCRIHEISCGAHST 125
KTC+ F C + C+ W+CDG+ DC DGSDE+PE C + C+ +E +C +
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNC-LGTE 83
Query: 126 QCIPVSWRCDGENDCDSGEDE--------ENCGNITC---------SPDEFTCSSGRCIS 168
C+P+S C+G DC G DE NC + C P + SS + +
Sbjct: 84 LCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQA 143
Query: 169 RNFVCNGQDDCS 180
C D+CS
Sbjct: 144 DGKTCKDFDECS 155
Score = 68.6 bits (166), Expect = 2e-11
Identities = 56/180 (31%), Positives = 77/180 (42%), Gaps = 27/180 (15%)
Query: 153 TCSPDEFTCSSG-RCISRNFVCNGQDDCSDGSDELDCAPP-----TCGAHEFQC-STSSC 205
TCSP +F C CIS+ + C+G+ DC DGSDE P C +E C T C
Sbjct: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85
Query: 206 IPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCK 265
+P+S +C+ DC D SDE C + C C H P C
Sbjct: 86 VPMSRLCNGVQDCMDGSDEG-----------PHCRELQGNCSRLGCQHHCVPTLDGPTCY 134
Query: 266 -DGSDEVNCPSRTCRPDQFECE-DGSCIHGSRQCNG--IRDCVDG----SDEVNCKNVNQ 317
+ S ++ +TC+ D EC G+C +G I CV+G D +CK N+
Sbjct: 135 CNSSFQLQADGKTCK-DFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNE 193
Score = 67.0 bits (162), Expect = 7e-11
Identities = 38/104 (36%), Positives = 49/104 (47%), Gaps = 11/104 (10%)
Query: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDE-----KNCVKKTCAESDFVCNNGQ-CV 85
C P QF C + CI+ W+CDG+ DC DGSDE + C ++ C + CV
Sbjct: 27 CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86
Query: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIP 129
P C+G DC DGSDE P C + C H C+P
Sbjct: 87 PMSRLCNGVQDCMDGSDEGP-HCRELQGNCSRLGCQHH---CVP 126
Score = 33.5 bits (75), Expect = 0.88
Identities = 14/35 (40%), Positives = 19/35 (54%)
Query: 349 DEPLKECHINECLVNNGGCSHICKDLVIGYECDCA 383
D ++ N+C VNNGGCS +C +C CA
Sbjct: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACA 830
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 522 bits (1345), Expect = e-148
Identities = 290/776 (37%), Positives = 397/776 (51%), Gaps = 87/776 (11%)
Query: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTC-AESDFVCNNGQCVPSR--- 88
C P+ F C NGRC+ ++CD DC DGSDE C+ + C A ++F+CNN +C+P
Sbjct: 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFIC 2800
Query: 89 ---------------------------------------WKCDGDPDCEDGSDESPEQCH 109
+ CDGD DC D SDE+P C
Sbjct: 2801 NGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCT 2860
Query: 110 MRTCRIHEISCGAHSTQCIPVSWRCDGENDC-DSGEDEENCGNI--TCSPDEFTCSSGRC 166
TC E C S +CIP W CD E DC D+ ++ +CG+ TC DEF C GRC
Sbjct: 2861 THTCSSSEFQCA--SGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRC 2918
Query: 167 ISRNFVCNGQDDCSDGSDE---LDCAPPTCGAHEFQCSTSS-----CIPISWVCDDDADC 218
I ++C+G +DC D SDE C C EF C CIP SWVCD D DC
Sbjct: 2919 IPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDC 2978
Query: 219 SDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTC 278
+D DE+ + C R+ C +E CG G CI K +RCD DC D SDE C +TC
Sbjct: 2979 TDGYDEN-QNCTRRT-----CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTC 3032
Query: 279 RPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVN--CKNVNQCLGPGKFKCRSGECIDISK 336
+ +QF C++G CI + C+ DC DGSDE+ C P +FKC +G CI++ K
Sbjct: 3033 QQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMK 3092
Query: 337 VCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHICKDLVIGYECDCAAGFELI-DRKTC 394
+CN DC D SDE K C INEC + GC H C D + + C C G++L+ D++TC
Sbjct: 3093 LCNHLDDCLDNSDE--KGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTC 3150
Query: 395 GDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK-EPSLIFTNRRDIR 452
DIDEC + P +CSQ C N+ G Y C+C+ GY + C+ EP LIF+NR +R
Sbjct: 3151 VDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLR 3210
Query: 453 KIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512
+ ++ Y ++E L N VALD D ++L+W D +Q+ + +K + + +
Sbjct: 3211 NLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWID-TQRQVIERMFLNKTNKETIINHRL 3269
Query: 513 YNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR--------EPASIAVD 564
++AVDWV + +YW DA + V+ L+G R+ L + P +A+
Sbjct: 3270 PAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALH 3329
Query: 565 PLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHML 624
P G++YW+DWG A I + GM+G ++ +++ ++WPNGIT+D LYW D+ L +
Sbjct: 3330 PQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYI 3389
Query: 625 SSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNN 684
DL G R V L HP A+TIFED +YW D V NK+ GS TLVN
Sbjct: 3390 EYSDLEGHHRHTVYDGA--LPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNT 3447
Query: 685 LNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
+ DI VYH QP N C NGGC +LCL I +TC CP +
Sbjct: 3448 THRPFDIHVYHPYRQPIVSNPC--GTNNGGCSHLCL----IKPGGKGFTCECPDDF 3497
Score = 504 bits (1298), Expect = e-142
Identities = 283/744 (38%), Positives = 395/744 (53%), Gaps = 32/744 (4%)
Query: 21 ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFV 78
E T +C F C NGRC+ + CDG +DC D SDE+ C + TC+ S F
Sbjct: 1014 EGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFT 1073
Query: 79 CNNGQCVPSRWKCDGDPDCEDGSDESPEQCHM-RTCRIHEISCGAHSTQCIPVSWRCDGE 137
C +G+C+P+ W+CD DC DGSDE H +C + +C H QCI +W CD +
Sbjct: 1074 CGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNH--QCISKNWVCDTD 1131
Query: 138 NDCDSGEDEENCGNI-TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAH 196
NDC G DE+NC + TC P +F C + RCI +FVC+G DC DGSDE+ C C A
Sbjct: 1132 NDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVL-NCTAS 1190
Query: 197 EFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGS-GECIHK 254
+F+C++ CI ++ CD DCSD SDE+ C +P C + E QC G CI
Sbjct: 1191 QFKCASGDKCIGVTNRCDGVFDCSDNSDEA--GCPTRPP--GMCHSDEFQCQEDGICIPN 1246
Query: 255 KWRCDGDPDCKDGSDEVN-CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
W CDG PDC GSDE N C +TC F C++G+CIH + C+ DC D SDE +C
Sbjct: 1247 FWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP 1306
Query: 314 NVNQCLGPGKFKCRSGE-CIDISKVCNQEQDCRDWSDE-PLKECHINECLVNNGGCSHIC 371
+++C C+++S VC+ DC + +DE PL C+ N C NGGC+H C
Sbjct: 1307 TQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPL--CNGNSCSDFNGGCTHEC 1364
Query: 372 KDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLA 430
G +C C GF L D KTC DIDEC G CSQ C N++G ++C C GY ++
Sbjct: 1365 VQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESD 1424
Query: 431 TGVCKAVGKEPSLIFT---NRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWAD 487
CK E L+ N+ + + LVE VA+D D + ++FW+D
Sbjct: 1425 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484
Query: 488 LSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
+Q +SA + R V ++ IA+DWV + +YWTD A +TI V+ +DG+ R
Sbjct: 1485 ATQGKTWSA-FQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHR 1543
Query: 548 KFLFNSDLREPASIAVDPLSG--FVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGI 605
L + +L P +A+DP ++WSDWG +IE+A M+G R +V I WP G+
Sbjct: 1544 TVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGL 1603
Query: 606 TLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENE 665
T+D LY++DS L + D NG RR V+ S + HP ALT+FED VYW D
Sbjct: 1604 TIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATR 1663
Query: 666 AVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQI 725
V ANK+ G + ++ N+ I+ H QP+ N C C +LCL + Q
Sbjct: 1664 RVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR----CSHLCLLSSQ- 1718
Query: 726 NDHSPKYTCSCPSGYNVEENGRDC 749
H Y+C CPSG+++ + +C
Sbjct: 1719 GPHF--YSCVCPSGWSLSPDLLNC 1740
Score = 484 bits (1246), Expect = e-136
Identities = 285/805 (35%), Positives = 404/805 (50%), Gaps = 115/805 (14%)
Query: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE--KNCVKKTCAESDFVCNNGQCVPSRWK 90
C+ +++QC N RCI W+CD DC D SDE +C +TC F C NG+C+P WK
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 3653
Query: 91 CDGDPDCEDGSDESPEQC----HM------------------------------------ 110
CD D DC D SDE E+C H+
Sbjct: 3654 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQG 3713
Query: 111 ---RTCR-IHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRC 166
RTC + + C H CIP+ W+CDG+NDC DEENC C+ EF C + +C
Sbjct: 3714 CEERTCHPVGDFRCKNH--HCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQC 3771
Query: 167 ISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESL 226
I ++C+ +DC D SDE DC TC FQC++ C+ CD ADC D SDE+
Sbjct: 3772 IPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEA- 3830
Query: 227 EQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVN--CPSRTCR-PDQF 283
C + C A+ +C + CI W+CDGD DC DGSDE C C P++F
Sbjct: 3831 -DCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRF 3889
Query: 284 ECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPG-------KFKCRSGECIDISK 336
C++ CI+ CNG+ DC DG+DE C P ++KC +G CI
Sbjct: 3890 RCDNNRCIYSHEVCNGVDDCGDGTDETE----EHCRKPTPKPCTEYEYKCGNGHCIPHDN 3945
Query: 337 VCNQEQDCRDWSDE------PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFE--L 388
VC+ DC DWSDE + C N C N C+ + + G+ C C AGFE +
Sbjct: 3946 VCDDADDCGDWSDELGCNKGKERTCAENICEQN---CTQLNEG---GFICSCTAGFETNV 3999
Query: 389 IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGY--QMDLATGVCKAVGKEPSLIFT 446
DR +C DI+EC+ G C Q C N KG Y+C C+ G+ D C A G P L+
Sbjct: 4000 FDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLP 4059
Query: 447 NRRDIRKIGLERKEYIQLVEQLRNTVALD-----ADIAAQKLFWADLSQKAIFSA----- 496
+ IRK L + + + ++ A+D DI +++ + + F A
Sbjct: 4060 DNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAY 4119
Query: 497 --SIDDKVGRHVKMID----NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFL 550
+ + V+ +D V P IAVDWV + IYW+D +K I VA LDG RK+L
Sbjct: 4120 IPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWL 4179
Query: 551 FNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
++DL +PA+IAV+P G ++W+DWG+ KIE A MNG DR LV D+ WP G+++D +
Sbjct: 4180 ISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYL 4239
Query: 611 KS-RLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYG 669
+ R+YW D K ++ ++ +G DRR++ K +P +L IFED++YWI E V+
Sbjct: 4240 NNDRIYWSDFKEDVIETIKYDGTDRRVIAKE---AMNPYSLDIFEDQLYWISKEKGEVWK 4296
Query: 670 ANKF-TGSELATLVNNLNDAQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQIND 727
NKF G + TLV N Q + ++H+L S N C++ C +LCL P
Sbjct: 4297 QNKFGQGKKEKTLVVNPWLTQ-VRIFHQLRYNKSVPNLCKQI-----CSHLCLLRP---- 4346
Query: 728 HSPKYTCSCPSGYN-VEENGRDCQS 751
Y+C+CP G + +E + +C +
Sbjct: 4347 --GGYSCACPQGSSFIEGSTTECDA 4369
Score = 455 bits (1171), Expect = e-128
Identities = 265/770 (34%), Positives = 385/770 (50%), Gaps = 86/770 (11%)
Query: 9 LWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV 68
L L L C AP A+G +C+ + F+C +G CI W+CDG +DC D +DE C
Sbjct: 12 LLLALVACLAP----ASGQ----ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCA 63
Query: 69 KKTCAESDFVC-NNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQC 127
TC + F C + GQC+P+ W CD D DC+DGSDE + C TC H+I+C + QC
Sbjct: 64 VVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDER-QDCSQSTCSSHQITCS--NGQC 120
Query: 128 IPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD 187
IP +RCD DC G DE +C TC ++ TC +G C + + C+ + DC D SDE++
Sbjct: 121 IPSEYRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEIN 178
Query: 188 CAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
C C +EF C CIP ++VCD D DC D SDE C + C + C
Sbjct: 179 CT-EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDE--HACN-----YPTCGGYQFTCP 230
Query: 248 SGECIHKKWRCDGDPDCKDGSDEVNCPS-----RTCRPDQFEC-EDGSCIHGSRQCNGIR 301
SG CI++ W CDG+ DCKD DE C S C P ++ C E G CI + C+GI
Sbjct: 231 SGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGIL 290
Query: 302 DCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECL 361
DC DE N GK+ C + C
Sbjct: 291 DCPGREDENNTST-------GKY------------------------------CSMTLCS 313
Query: 362 VNNGGCSHICKDLVIGYECDCAAGFEL--IDRKTCGDIDECQNPGICSQICINLKGGYKC 419
N C + C + G C C G+ + D +TC + D+CQ GIC Q C + G + C
Sbjct: 314 ALN--CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLC 371
Query: 420 ECSRGYQMDLATGVCKAVGK--EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDA- 476
C GY ++ CKA E S+IF+N RD+ + + + LVE VA+
Sbjct: 372 HCEEGYILERGQ-YCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVA 430
Query: 477 -DIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDN--VYNPAAIAVDWVYKTIYWTDAA 533
Q++FW D Q +FS I+ G +++ + N V P +AVDWV IY +
Sbjct: 431 FHYHLQRVFWTDTVQNKVFSVDIN---GLNIQEVLNVSVETPENLAVDWVNNKIYLVETK 487
Query: 534 SKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW----GEPAKIEKAGMNGF 589
I + LDG+ R L +L P IAVDP G++++SDW GEP K+E+A M+G
Sbjct: 488 VNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEP-KLERAFMDGS 546
Query: 590 DRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLA 649
+R+ LV + WP G+TLD+I R+YW+DS+ + +V +G R+ V+ + HP
Sbjct: 547 NRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFG 606
Query: 650 LTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709
+++FE +V++ D AV ANKFT + + VYH L QP N C+++
Sbjct: 607 VSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDN 666
Query: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYS 759
NGGCE +C+ + + ++ + C C G+ ++ + R C + + +S
Sbjct: 667 --NGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFS 714
Score = 189 bits (481), Expect = 7e-48
Identities = 118/308 (38%), Positives = 150/308 (48%), Gaps = 31/308 (10%)
Query: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKC 91
+C S+F+C N +CI W CD DC D SDE++C +TC F C +G CV S KC
Sbjct: 3758 ECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKC 3817
Query: 92 DGDPDCEDGSDESPEQCHMR-----TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146
DG DC D SDE+ C R C+ C H CIP W+CDG++DC G DE
Sbjct: 3818 DGSADCLDASDEA--DCPTRFPDGAYCQATMFECKNH--VCIPPYWKCDGDDDCGDGSDE 3873
Query: 147 E--NCGNITC-SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD--CAPPT---CGAHEF 198
E C ++ C SP+ F C + RCI + VCNG DDC DG+DE + C PT C +E+
Sbjct: 3874 ELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEY 3933
Query: 199 QCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ-PVIHTKCPASEIQCGSGECIHKKWR 257
+C CIP VCDD DC D SDE G++ C + Q G I
Sbjct: 3934 KCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFI----- 3988
Query: 258 CDGDPDCKDGSDEVNCPSRTCRPDQFECED-GSCIHGSRQCNGIRDCV--DGSDEVNCKN 314
C C G E N RT D ECE G+C R G +CV DG ++ +
Sbjct: 3989 C----SCTAGF-ETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRP 4043
Query: 315 VNQCLGPG 322
+C G
Sbjct: 4044 GKRCAAEG 4051
Score = 179 bits (455), Expect = 8e-45
Identities = 111/365 (30%), Positives = 179/365 (49%), Gaps = 24/365 (6%)
Query: 402 NPGICSQICI------NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
N G C Q+C+ N G++C+C+ G+Q+D C AV + LIF+++ IR I
Sbjct: 666 NNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAV--QNFLIFSSQVAIRGIP 723
Query: 456 LERKEYIQLVEQLRNT----VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDN 511
++ + V +D D +F++D+S+ IF ID GR + +
Sbjct: 724 FTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDG-TGREILAANR 782
Query: 512 VYNPAAIAVDWVYKTIYWTDAASKTISVATL-DGTKRKFLFNSDLREPASIAVDPLSGFV 570
V N ++A DW+ K +YWTD+ K+ISV L D T+R + L P S+ V P +G++
Sbjct: 783 VENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYLNNPRSVVVHPFAGYL 840
Query: 571 YWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLN 630
+++DW PAKI +A +G P++ + WPNG+ +D SRLYW+D+ + +
Sbjct: 841 FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD 900
Query: 631 GQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQD 690
G DRR L +E + HP L IF + +++ D A+ K G E+ + + +
Sbjct: 901 GLDRR-RLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILH 959
Query: 691 IIVYHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
+ Y +Q +G N C + NG C + C P P + C CP G + N C
Sbjct: 960 LKSYDVNIQ-TGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYGMRLASNHLTC 1013
Query: 750 QSTAT 754
+ T
Sbjct: 1014 EGDPT 1018
Score = 165 bits (417), Expect = 2e-40
Identities = 112/421 (26%), Positives = 188/421 (44%), Gaps = 73/421 (17%)
Query: 354 ECHINECLVNNGGCSHICKDL--VIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICI 411
E + N CL NNGGCSH+C L + +CDCA G D K C
Sbjct: 2340 EVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNC----------------- 2382
Query: 412 NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEY---IQLVEQL 468
A+ E LIF +R + L+ + + Q +
Sbjct: 2383 ------------------------AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 2418
Query: 469 RNTVALDADIAAQKLFWADLSQKA---IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYK 525
R ++LD D + ++++ I A++ + + + IA DW+ +
Sbjct: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478
Query: 526 TIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAG 585
IY++D ++ I+ DG+ R + + + +P +I +DP G++YW+DW AKIE+A
Sbjct: 2479 RIYYSDYLNQMINSMAEDGSNRTVI--ARVPKPRAIVLDPCQGYLYWADWDTHAKIERAT 2536
Query: 586 MNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645
+ G R P+V + + P+G+TLD + LYW+D+ L + L G DR +++ +
Sbjct: 2537 LGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNA---AV 2593
Query: 646 HPLALTIFEDRVYWIDGENEAVYGANKFTGS-ELATLVNNLNDAQDIIVYHELVQPSGKN 704
H LT++ +YW D + +Y ANK+ GS ++A N L+ + I + + N
Sbjct: 2594 HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNN 2653
Query: 705 WCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYN----------VEENGRDCQSTAT 754
CE+ NGGC ++C P P + C CP N + +NG C +++
Sbjct: 2654 PCEQ--FNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHCIVDNGERCGASSF 2705
Query: 755 T 755
T
Sbjct: 2706 T 2706
Score = 152 bits (385), Expect = 1e-36
Identities = 100/373 (26%), Positives = 189/373 (50%), Gaps = 40/373 (10%)
Query: 402 NPGICSQICINLKGG-YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
N C QIC+ + GG + C C+ G++++ C ++ + IR LE +
Sbjct: 2025 NMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNS--FIVVSMLSAIRGFSLELSD 2082
Query: 461 Y----IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK----MIDNV 512
+ + + Q RN + +D D+++ ++W D S S+ D R +K + N+
Sbjct: 2083 HSETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-----SSVASDNAIRRIKPDGSSLMNI 2137
Query: 513 YNPA-------AIAVDWVYKTIYWTDA--ASKTISVATLDGTKRKFLFNSDLREPASIAV 563
IAVDWV +Y+T+A + I V ++ T R+ L + P I V
Sbjct: 2138 VTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVV 2197
Query: 564 DPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHM 623
DP + +++W+D+G+ KIE++ ++ +R LV+ I P G+ +D +YW+D L +
Sbjct: 2198 DPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDI 2257
Query: 624 LSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKF-TGSELATLV 682
++ + +NG++ ++ + P +T+FE+ + W+D + ++ A+K +E T++
Sbjct: 2258 IARIRINGENSEVIRYGSRY-PTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVI 2316
Query: 683 -NNLNDAQDIIVYHELVQPS-----GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
+N+N +D+ ++ + VQP N C E+ NGGC +LC P + H+PK C C
Sbjct: 2317 RDNINWLRDVTIFDKQVQPRSPAEVNNNPCLEN--NGGCSHLCFALPGL--HTPK--CDC 2370
Query: 737 PSGYNVEENGRDC 749
G ++ +G++C
Sbjct: 2371 AFG-TLQSDGKNC 2382
Score = 135 bits (341), Expect = 1e-31
Identities = 74/237 (31%), Positives = 117/237 (49%), Gaps = 25/237 (10%)
Query: 191 PTCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG 249
P C + +F C+ + CIPI W CD DCSD SDE L C ++ C + QC G
Sbjct: 3510 PMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE-LALCPQR-----FCRLGQFQCSDG 3563
Query: 250 ECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
C + C+ +C DGSDE + C + C ++++C + CI S QC+ DC D S
Sbjct: 3564 NCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNS 3623
Query: 308 DEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGC 367
DE + ++ PG+F+C +G CI + C+ + DC D SDEP++EC
Sbjct: 3624 DEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECM---------SS 3674
Query: 368 SHICKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGI---CSQICINLKGGYKCE 420
+H+C + E C + I + C +D+C++ C + + G ++C+
Sbjct: 3675 AHLCDNFT---EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCK 3728
Score = 133 bits (334), Expect = 8e-31
Identities = 95/362 (26%), Positives = 168/362 (46%), Gaps = 30/362 (8%)
Query: 406 CSQICINLKGG---YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL----ER 458
CS +C+ G Y C C G+ + C +P LI + I I L +
Sbjct: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLR-DDQPFLITVRQHIIFGISLNPEVKS 1767
Query: 459 KEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
+ + + ++N + ++ D A Q ++W + + I D I V +
Sbjct: 1768 NDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNL 1826
Query: 519 AVDWVYKTIYWTDAASKTISVATLDGT--KRKFLFNSD-----LREPASIAVDPLSGFVY 571
A+DW+ + +Y T+ +++I V TL G RK L +D + P I VDP G +Y
Sbjct: 1827 ALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLY 1886
Query: 572 WSDWGE----PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
WSD G PAKI A M+G + L T +++ +TLD+ + +LYW + ++
Sbjct: 1887 WSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERG 1946
Query: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
+++G DR I++ L+HP + + + +Y+ D + E + +K TG+ L +N+ +
Sbjct: 1947 NVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPN 2003
Query: 688 AQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR 747
+ + VYH N C +M C+ +CLP P ++C+C +G+ + + R
Sbjct: 2004 LRGLQVYHRRNAAESSNGCSNNM--NACQQICLPVP-----GGLFSCACATGFKLNPDNR 2056
Query: 748 DC 749
C
Sbjct: 2057 SC 2058
Score = 103 bits (258), Expect = 5e-22
Identities = 56/142 (39%), Positives = 74/142 (52%), Gaps = 12/142 (8%)
Query: 31 AKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKTC-AESDFVCNNGQCVPS 87
A C+ + F+C N CI WKCDGD+DC DGSDE+ C+ C + + F C+N +C+ S
Sbjct: 3840 AYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYS 3899
Query: 88 RWKCDGDPDCEDGSDESPEQCHMRT---CRIHEISCGAHSTQCIPVSWRCDGENDCDSGE 144
C+G DC DG+DE+ E C T C +E CG + CIP CD +DC
Sbjct: 3900 HEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCG--NGHCIPHDNVCDDADDCGDWS 3957
Query: 145 DEENCGNITCSPDEFTCSSGRC 166
DE C E TC+ C
Sbjct: 3958 DELGCN----KGKERTCAENIC 3975
Score = 36.6 bits (83), Expect = 0.10
Identities = 27/89 (30%), Positives = 36/89 (40%), Gaps = 17/89 (19%)
Query: 337 VCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDC--AAGFELIDRKTC 394
V NQ+Q C N C NGGCSHIC G EC C + L + +
Sbjct: 2644 VKNQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKH 2691
Query: 395 GDIDECQNPGICSQICIN---LKGGYKCE 420
+D + G S C N + +KC+
Sbjct: 2692 CIVDNGERCGASSFTCSNGRCISEEWKCD 2720
Score = 32.3 bits (72), Expect = 2.0
Identities = 18/55 (32%), Positives = 30/55 (54%), Gaps = 7/55 (12%)
Query: 732 YTCSCPSGYNVEENGRDCQSTAT----TVTYSETK---DTNTTEISATSGLVPGG 779
+ CSC +GY +E +GR C+ TA+ + S+ K D+ T+++ LV G
Sbjct: 1411 FRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENG 1465
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 520 bits (1339), Expect = e-147
Identities = 280/760 (36%), Positives = 407/760 (53%), Gaps = 38/760 (5%)
Query: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKTCAESDFVCNNGQCVPSRWK 90
C+ +F+C N CI WKCDGD+DC+DGSDE NC +C + F C N +C+P RW
Sbjct: 845 CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904
Query: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENC 149
CDG DC DES + C RTC++ + SCG + +CIP +W CD E+DC DE +C
Sbjct: 905 CDGANDCGSNEDESNQTCTARTCQVDQFSCG--NGRCIPRAWLCDREDDCGDQTDEMASC 962
Query: 150 GNITCSP-DEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPI 208
TC P +F C SGRCIS + C+ DDC DGSDE+ C +C ++F+CS+ CIP
Sbjct: 963 EFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVH-SCFDNQFRCSSGRCIPG 1021
Query: 209 SWVCDDDADCSDQSDESLEQCGRQPVIHTK--CPASEIQCG-SGECIHKKWRCDGDPDCK 265
W CD D DC D SDE+ C ++ IH+ C +E QC G C+ WRCDG+ DC+
Sbjct: 1022 HWACDGDNDCGDFSDEAQINCTKEE-IHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE 1080
Query: 266 DGSDEVNCPS--RTC-RPDQFEC-EDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 321
DGSDE C R C +F C G CI+ + C+G DC D SDE +C + GP
Sbjct: 1081 DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSF--LCGP 1138
Query: 322 GKFKCRSGE--CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV-IGY 378
K C + C+ K+CN ++DC D SDE +EC +NNGGCS+ C + G
Sbjct: 1139 PKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYL---CDECSLNNGGCSNHCSVVPGRGI 1195
Query: 379 ECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
C C G +L D KTC +D C N CSQ+C K KC C G+++D+ C +V
Sbjct: 1196 VCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSV 1255
Query: 438 GK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSA 496
E +IF+ R +IR+I L +++Y LV LRNT+ALD L+W D+ + I+
Sbjct: 1256 DPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRG 1315
Query: 497 SIDDKVGR---HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNS 553
+ + G V + + P + VDW+ IYW D+ I VA LDG+ R L
Sbjct: 1316 KLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAG 1375
Query: 554 DLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQ---WPNGITLDL 609
+ P +IA+DP G ++W+DW +IE A M+G R+ + D++ WPNG+T+D
Sbjct: 1376 AMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK-DMKTGAWPNGLTVDH 1434
Query: 610 IKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYG 669
+ R+ W D++ + S +G + +++ E+L+HP A++++ VYW D +
Sbjct: 1435 FEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSK 1494
Query: 670 ANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHS 729
ANK+TG ++ + D+ +YH QP N C + G C ++CL IN H+
Sbjct: 1495 ANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCL----IN-HN 1549
Query: 730 PKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEI 769
C+CP + + + C + Y+ + +I
Sbjct: 1550 RSAACACPHLMKLSSDKKTCYEMKKFLLYARRSEIRGVDI 1589
Score = 502 bits (1293), Expect = e-142
Identities = 282/748 (37%), Positives = 407/748 (54%), Gaps = 46/748 (6%)
Query: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAE--------SDFV-CNNGQ 83
C +F+C +G CI +C+ + DC D SDEKNC C + F+ CN+
Sbjct: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS 2650
Query: 84 -CVPSRWKCDGDPDCEDGSDE--SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140
CV W CDG DC D SDE P Q + C + SC S +CI +W CDG+ DC
Sbjct: 2651 LCVLPTWICDGSNDCGDYSDELKCPVQ-NKHKCEENYFSCP--SGRCILNTWICDGQKDC 2707
Query: 141 DSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD--CAPPTCGAHEF 198
+ G DE +C + +CS ++F CS+ +CIS++++C+G+DDC DG DE D C TC A F
Sbjct: 2708 EDGRDEFHCDS-SCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMF 2766
Query: 199 QCSTS-SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWR 257
C S +C+P W+CD + DC D SDE L G P + C + C + CI K++
Sbjct: 2767 SCQGSRACVPRHWLCDGERDCPDGSDE-LSTAGCAP--NNTCDENAFMCHNKVCIPKQFV 2823
Query: 258 CDGDPDCKDGSDEV-NCPSRTCRPDQFECEDGSCIHGSR-QCNGIRDCVDGSDEV----N 311
CD D DC DGSDE C R C ++F C DG C+ ++ QC+G DC D SDE
Sbjct: 2824 CDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPK 2883
Query: 312 CKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHI 370
CK+ Q F C++G CI +C+ + DC D SDE + CHINECL GCS
Sbjct: 2884 CKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDE--RNCHINECLSKKVSGCSQD 2941
Query: 371 CKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQM-- 427
C+DL + Y+C C GF+L D KTC DIDEC + CSQ CIN G YKC C+ GY++
Sbjct: 2942 CQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQP 3001
Query: 428 DLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWAD 487
D G +EP LI + +IRKI + Y L + L N +A+D D + ++W D
Sbjct: 3002 DNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWID 3061
Query: 488 LSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
S+ + G +K++ N P A+AVDW+ K +YW+D + I V+ L+G
Sbjct: 3062 SSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYP 3121
Query: 548 KFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITL 607
L + L+ P +++DP +G++YW D E I + GM+G ++ ++ I P +T+
Sbjct: 3122 TILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTI 3181
Query: 608 DLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAV 667
D + RLYW D S++D G R V + + +ALT+FED +YW DG+ +++
Sbjct: 3182 DYVNRRLYWADENHIEFSNMD--GSHRHKVPN--QDIPGVIALTLFEDYIYWTDGKTKSL 3237
Query: 668 YGANKFTGSELATLVNNLNDAQDIIVYHELVQPS-GKNWCEEDMENGGCEYLCLPAPQIN 726
A+K +G++ +L+ + + DI VYH QP K+ C + NGGC +LCL AP
Sbjct: 3238 SRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCM--INNGGCSHLCLLAP--- 3292
Query: 727 DHSPKYTCSCPSGYNVEENGRDCQSTAT 754
+TC+CP+ + + + R C S T
Sbjct: 3293 --GKTHTCACPTNFYLAADNRTCLSNCT 3318
Score = 419 bits (1076), Expect = e-117
Identities = 265/762 (34%), Positives = 363/762 (47%), Gaps = 87/762 (11%)
Query: 30 KAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRW 89
K C P +FQC N CI W+CD DC D SDE+NC +TC DF+C NG CV SR+
Sbjct: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
Query: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
CDGD DC DGSDE C +C + C + QCIP W+CDG DC GEDE++C
Sbjct: 3533 WCDGDFDCADGSDE--RNCE-TSCSKDQFRCS--NGQCIPAKWKCDGHEDCKYGEDEKSC 3587
Query: 150 --GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSS-CI 206
+ TCS E+ C+S CIS + CNG+ DC+DGSDE+DC C +F+C + CI
Sbjct: 3588 EPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCV-TECKEDQFRCKNKAHCI 3646
Query: 207 PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKD 266
PI W+CD DC D SDE E C R I C A E C + C W CDG+ DC D
Sbjct: 3647 PIRWLCDGIHDCVDGSDE--ENCERGGNI---CRADEFLCNNSLCKLHFWVCDGEDDCGD 3701
Query: 267 GSDEVN-------CPS---RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC---- 312
SDE CPS CR ++ C+ + CNGI +C D SDE +C
Sbjct: 3702 NSDEAPDMCVKFLCPSTRPHRCRNNRI------CLQSEQMCNGIDECGDNSDEDHCGGKL 3755
Query: 313 -KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHIN------ECLVNNG 365
C +F C + +CI + C++ DC D SDE + C I E VN
Sbjct: 3756 TYKARPC-KKDEFACSNKKCIPMDLQCDRLDDCGDGSDE--QGCRIAPTEYTCEDNVNPC 3812
Query: 366 GCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRG 424
G C + C C GF+ + + C D++EC G CS CIN++G YKC C +
Sbjct: 3813 GDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQN 3872
Query: 425 YQMDLATGVCKAVGKEPSLIF-TNRRDIRKIGL-------ERKEYIQLVEQLRNTVALDA 476
+Q C A G E +++ N DI +G + I +E +D
Sbjct: 3873 FQE--RNNTCIAEGSEDQVLYIANDTDI--LGFIYPFNYSGDHQQISHIEHNSRITGMDV 3928
Query: 477 DIAAQKLFWA-DLSQKAIFSASIDDKVGRHVK---MIDNVYNPAAIAVDWVYKTIYWTD- 531
+ W+ + IF I + R + P IAVDWV IYWTD
Sbjct: 3929 YYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDH 3988
Query: 532 --------------AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGE 577
+ +I+V L+G L + EP +IAV+P G +YW+ G+
Sbjct: 3989 SRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGD 4048
Query: 578 PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIV 637
+ IE+A M+G RR LV ++Q P G+ +D R+YW D +L ++ SV +G + +
Sbjct: 4049 HSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVS 4108
Query: 638 LKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHEL 697
+ S + L HP + IFED +Y G V+ KF + L N++ + +++ H
Sbjct: 4109 VSSKQGLLHPHRIDIFEDYIYGA-GPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRY 4167
Query: 698 VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSG 739
Q N C + CE+LCL P TC CP G
Sbjct: 4168 KQLDLPNPCLD----LACEFLCLLNPS------GATCVCPEG 4199
Score = 291 bits (746), Expect = 1e-78
Identities = 145/353 (41%), Positives = 193/353 (54%), Gaps = 16/353 (4%)
Query: 31 AKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNNGQCVPSRW 89
+ C SQF+C +CI WKCD +DC DGSDE +C + C F C G C +
Sbjct: 3315 SNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAF 3374
Query: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
CDG+ DC D SDE C C + C + +CIPV+ RC+G++DC EDE +C
Sbjct: 3375 ICDGENDCGDNSDEL--NCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
Query: 150 GNITCSPDEFTCSSGR-CISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPI 208
+CSPD F C + + CIS+ +VC+ DC+D SDE +C TCG HEFQC ++CIP
Sbjct: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPD 3491
Query: 209 SWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGS 268
W CD DCSD SDE E C Q C + C +G+C+ ++ CDGD DC DGS
Sbjct: 3492 HWRCDSQNDCSDNSDE--ENCKPQ-----TCTLKDFLCANGDCVSSRFWCDGDFDCADGS 3544
Query: 269 DEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRS 328
DE NC + +C DQF C +G CI +C+G DC G DE +C+ + ++ C S
Sbjct: 3545 DERNCET-SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS 3603
Query: 329 GECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECD 381
CI S CN E DC D SDE +C + EC + C + + I + CD
Sbjct: 3604 DGCISASLKCNGEYDCADGSDE--MDC-VTECKEDQFRCKNKAHCIPIRWLCD 3653
Score = 269 bits (687), Expect = 1e-71
Identities = 136/345 (39%), Positives = 177/345 (51%), Gaps = 23/345 (6%)
Query: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQ-CVPSRWK 90
+C+P +FQC G C + CDG+ DC D SDE NC C F C Q C+P +
Sbjct: 3356 RCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLR 3415
Query: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
C+G DC D DE C +C C + CI W CD + DC DE NC
Sbjct: 3416 CNGQDDCGDEEDE--RDCPENSCSPDYFQCKT-TKHCISKLWVCDEDPDCADASDEANCD 3472
Query: 151 NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISW 210
TC P EF C + CI ++ C+ Q+DCSD SDE +C P TC +F C+ C+ +
Sbjct: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532
Query: 211 VCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
CD D DC+D SDE C T C + +C +G+CI KW+CDG DCK G DE
Sbjct: 3533 WCDGDFDCADGSDE--RNC------ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDE 3584
Query: 271 VNC--PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRS 328
+C S TC ++ C CI S +CNG DC DGSDE++C V +C +F+C++
Sbjct: 3585 KSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC--VTEC-KEDQFRCKN 3641
Query: 329 -GECIDISKVCNQEQDCRDWSDEPLKE-----CHINECLVNNGGC 367
CI I +C+ DC D SDE E C +E L NN C
Sbjct: 3642 KAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLC 3686
Score = 224 bits (571), Expect = 3e-58
Identities = 149/535 (27%), Positives = 243/535 (45%), Gaps = 72/535 (13%)
Query: 239 CPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDEV--NCPSRT---CRPDQFEC-EDGSCI 291
C E C C+ + W CDGDPDC D SDE CP C + C C+
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 292 HGSRQCNGIRDCVDGSDE-VNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
H S+ CNG+ DC DG DE V+C+ +
Sbjct: 92 HLSQLCNGVLDCPDGYDEGVHCQEL----------------------------------- 116
Query: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQI 409
++ C N C + C + C C GFE+ D ++C D DEC G CSQ
Sbjct: 117 ------LSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQT 168
Query: 410 CINLKGGYKCECSRGYQMDLATGVCKA----VGKEPSLIFTNRRDIRKIGLERKEYIQLV 465
C N G Y C C GY M CKA + P L+ N I L + L
Sbjct: 169 CRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLS 228
Query: 466 EQLRNTV-ALDADIAAQKLFWADLSQKAIFSASID-DKVGR-----HVKMIDNVYNPAAI 518
N + LD + W + + + I K G + ++ + +N +
Sbjct: 229 SVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQM 288
Query: 519 AVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEP 578
A+DW+ + +Y+ D I V +G+ L + +L P +IAVDP++G ++++D+G
Sbjct: 289 AIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNV 348
Query: 579 AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVL 638
AK+E+ M+G +R ++ + + P + LDL+ +YW+D L + VD G++R V+
Sbjct: 349 AKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVI 408
Query: 639 KSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELV 698
+ + + H +T+FED +Y + +N + N+F G+++ +L+ + +A I +Y +
Sbjct: 409 QGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLI-KIENAWGIRIYQKRT 466
Query: 699 QPSGKNW-CEEDMEN--GGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
QP+ ++ CE D GGC ++CL ++ TC C +G+N+ +GR C+
Sbjct: 467 QPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCRTGFNLGSDGRSCK 517
Score = 199 bits (506), Expect = 9e-51
Identities = 118/371 (31%), Positives = 163/371 (43%), Gaps = 70/371 (18%)
Query: 110 MRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENCGNITCSPDEFTCSSGRCIS 168
+ C + C + +CIP W+CD +DC G DE ++C C P F C +G C
Sbjct: 3314 LSNCTASQFRC--KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCAL 3371
Query: 169 RNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCS-TSSCIPIS------------------ 209
F+C+G++DC D SDEL+C C + +F+C+ CIP++
Sbjct: 3372 PAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431
Query: 210 ----------------------WVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
WVCD+D DC+D SDE+ C ++ C E QC
Sbjct: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEA--NCDKK-----TCGPHEFQCK 3484
Query: 248 SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
+ CI WRCD DC D SDE NC +TC F C +G C+ C+G DC DGS
Sbjct: 3485 NNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGS 3544
Query: 308 DEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKE-----CHINECLV 362
DE NC+ +F+C +G+CI C+ +DC+ DE E C E +
Sbjct: 3545 DERNCET---SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYIC 3601
Query: 363 NNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDE--CQNPGICSQICINLKGGYKC- 419
+ GC I L E DCA G + +D T D+ C+N C I G + C
Sbjct: 3602 ASDGC--ISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCV 3659
Query: 420 ------ECSRG 424
C RG
Sbjct: 3660 DGSDEENCERG 3670
Score = 181 bits (459), Expect = 3e-45
Identities = 126/371 (33%), Positives = 180/371 (48%), Gaps = 30/371 (8%)
Query: 396 DIDECQNPGICSQICINLKGGYK---CECSRGYQMDLATGVCKAVGKEPSLIFTNRRD-- 450
++D PG CS IC+ L YK C C G+ + CK E L + R
Sbjct: 476 EVDPYGMPGGCSHICL-LSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGI 534
Query: 451 IRKIGLERK---EYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK 507
+R + L K EY+ +E L N ALD +++AD + I ID R
Sbjct: 535 VRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG-TERETI 593
Query: 508 MIDNVYNPAAIAVDWVYKTIYWT-DAASKTISVATLD--GTKRKFLFNSDLREPASIAVD 564
+ D++ N IAVDW+ +YWT D KTI+VA L+ RK L ++ P I VD
Sbjct: 594 LKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVD 653
Query: 565 PLSGFVYWSDWGEP------AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLD 618
P++G++YW+DW E +IEKA M+GF+R+ VT+ + WPNG+TLD + LYW D
Sbjct: 654 PVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCD 713
Query: 619 SKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSEL 678
+ + V LNG R+IV E L HP L+ + V+W D N +++ + T SE+
Sbjct: 714 AYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT-SEV 771
Query: 679 ATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPS 738
L + + +Y Q G N C + NGGC LCL P C+C
Sbjct: 772 TLLRHERPPLFGLQIYDPRKQ-QGDNMCR--VNNGGCSTLCLAIP------GGRVCACAD 822
Query: 739 GYNVEENGRDC 749
++ENG C
Sbjct: 823 NQLLDENGTTC 833
Score = 171 bits (434), Expect = 2e-42
Identities = 106/321 (33%), Positives = 147/321 (45%), Gaps = 27/321 (8%)
Query: 113 CRIHEISCGAHST------QCIPVSWRCDGENDCDSGEDEE--NCGNITCSPDEFTCSSG 164
C SC A+S +CI CDG C DE+ C N +C C +
Sbjct: 2503 CVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNR 2562
Query: 165 RCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 224
RCI +C+G++DC D SDELDC TC EF+C+ +CIP S C+ + DC+D SDE
Sbjct: 2563 RCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDE 2622
Query: 225 SLEQCGRQPVIH----TKCPASEIQCGSGE-CIHKKWRCDGDPDCKDGSDEVNCP---SR 276
+ C H I+C S C+ W CDG DC D SDE+ CP
Sbjct: 2623 --KNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKH 2680
Query: 277 TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISK 336
C + F C G CI + C+G +DC DG DE +C + +F C + +CI
Sbjct: 2681 KCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHC---DSSCSWNQFACSAQKCISKHW 2737
Query: 337 VCNQEQDCRDWSDEPLKECHINECLVNNGGC--SHIC--KDLVIGYECDCAAGFELIDRK 392
+C+ E DC D DE C C + C S C + + E DC G + +
Sbjct: 2738 ICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTA 2797
Query: 393 TCGDIDEC-QNPGIC-SQICI 411
C + C +N +C +++CI
Sbjct: 2798 GCAPNNTCDENAFMCHNKVCI 2818
Score = 162 bits (410), Expect = 1e-39
Identities = 118/421 (28%), Positives = 196/421 (46%), Gaps = 28/421 (6%)
Query: 347 WSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQ-NPGI 405
W+D+ L + + C +G I ++ G ++ D++ + CQ N G
Sbjct: 1792 WADQNLAQ--LGTCSKRDGRNPTILRNKTSG-----VVHMKVYDKEAQQGSNSCQLNNGG 1844
Query: 406 CSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL 464
CSQ+C+ + C C+ GY + C+ + E L+++ IR I LE + +
Sbjct: 1845 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGI--ESFLMYSVHEGIRGIPLEPSDKMDA 1902
Query: 465 VEQLRNT---VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
+ + T V +D ++W D+ I A D + + + + IAVD
Sbjct: 1903 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDI-ITNGLGRVEGIAVD 1961
Query: 522 WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
W+ IYWTD I VA L+G+ R + + L +P SIAV P G ++W++WG+ I
Sbjct: 1962 WIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCI 2021
Query: 582 EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL-NGQDRRIVLKS 640
KA ++G ++ LV+ I WPNGI++D +++LYW D++ + +DL G +R +VL
Sbjct: 2022 GKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSG 2081
Query: 641 LEFLAHPLALTIFEDRVYWID--GENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELV 698
++ +F +YW D N +V +K +E T+ L + V
Sbjct: 2082 SN--VDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRV 2139
Query: 699 QPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTY 758
+ G N C D NGGC+ LCL + + TC+C GY + E+G C + Y
Sbjct: 2140 REKGTNVCARD--NGGCKQLCL-----YRGNSRRTCACAHGY-LAEDGVTCLRHEGYLLY 2191
Query: 759 S 759
S
Sbjct: 2192 S 2192
Score = 145 bits (366), Expect = 2e-34
Identities = 73/175 (41%), Positives = 100/175 (57%), Gaps = 13/175 (7%)
Query: 23 GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKT------CAE 74
G+ G C +QF+C++GRCI W CDGD DC D SDE NC K+ C
Sbjct: 996 GSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNG 1055
Query: 75 SDFVCN-NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHST-QCIPVSW 132
++F C+ +G CVP W+CDG+ DCEDGSDE +R C H+ ST +CI +W
Sbjct: 1056 NEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCD-HKTKFSCWSTGRCINKAW 1114
Query: 133 RCDGENDCDSGEDEENCGNITCSPDEFTCSSGR--CISRNFVCNGQDDCSDGSDE 185
CDG+ DC+ DE++C + C P + C++ C+ +CNG+ DC DGSDE
Sbjct: 1115 VCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
Score = 136 bits (343), Expect = 7e-32
Identities = 94/363 (25%), Positives = 171/363 (47%), Gaps = 23/363 (6%)
Query: 404 GICSQIC-INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
G CS +C IN C C ++ C + K L++ R +IR + ++ +
Sbjct: 1538 GPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK--FLLYARRSEIRGVDIDNPYFN 1595
Query: 463 QL----VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
+ V + + +D D + ++L+W D+ + I A I+ G + ++ + +
Sbjct: 1596 FITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFING-TGLETVISRDIQSIRGL 1654
Query: 519 AVDWVYKTIYWTDAA--SKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG 576
AVDWV + +YW + I+VA LDG+ + + + + +P +A P+ G +YW+D
Sbjct: 1655 AVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQCLAAHPVRGKLYWTDGN 1713
Query: 577 EPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRI 636
I A M+G + + L + P G+++D ++++LYW+ S ++ +L+G + +
Sbjct: 1714 T---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEV 1769
Query: 637 VLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHE 696
+ E L ALTI + +++W D + +K G L N + + VY +
Sbjct: 1770 IESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDK 1829
Query: 697 LVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTV 756
Q G N C+ + NGGC LCLP + TC C GY +++N CQ + +
Sbjct: 1830 EAQ-QGSNSCQ--LNNGGCSQLCLPTSETT-----RTCMCTVGYYLQKNRMSCQGIESFL 1881
Query: 757 TYS 759
YS
Sbjct: 1882 MYS 1884
Score = 135 bits (340), Expect = 2e-31
Identities = 69/185 (37%), Positives = 91/185 (49%), Gaps = 9/185 (4%)
Query: 187 DCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQC 246
+ P C A EF+C CI W CD D DC D SDE C + CP + +C
Sbjct: 839 EALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC-----FNHSCPDDQFKC 893
Query: 247 GSGECIHKKWRCDGDPDCKDGSDEVN--CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCV 304
+ CI K+W CDG DC DE N C +RTC+ DQF C +G CI + C+ DC
Sbjct: 894 QNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCG 953
Query: 305 DGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEP--LKECHINECLV 362
D +DE+ C +F C+SG CI C+ + DC D SDE + C N+
Sbjct: 954 DQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRC 1013
Query: 363 NNGGC 367
++G C
Sbjct: 1014 SSGRC 1018
Score = 110 bits (275), Expect = 6e-24
Identities = 90/380 (23%), Positives = 170/380 (44%), Gaps = 39/380 (10%)
Query: 404 GICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
G C Q+C+ + C C+ GY LA + E L+++ R ++ I L + +
Sbjct: 2152 GGCKQLCLYRGNSRRTCACAHGY---LAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNL 2208
Query: 463 -------QLVEQLRNTVALDADI-----AAQKLFWADLSQKAIFSASIDDKVGRHVKMID 510
+ +N +AL D ++F++D I I D +++
Sbjct: 2209 NSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI--QLIKDNWEDRQVIVE 2266
Query: 511 NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK------RKFLFNSDLREPASIAVD 564
NV + +A + T+YWT + + +I+ T+D T+ + S+ P +A+D
Sbjct: 2267 NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALD 2326
Query: 565 PLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHM 623
++W++W E I ++ + G + + +V+ DI PNG+T+D +LY+ D L
Sbjct: 2327 ECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGK 2386
Query: 624 LSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVN 683
+ + +G R +++KS L+L ++++ ++W D A+ +NK+TG + L +
Sbjct: 2387 IERCEYDGSQRHVIVKSGP--GTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRS 2444
Query: 684 NLNDAQDIIVYHELVQPSGKNWCEED---MENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
++ I+ + N CE + NGGC LCL P + + CSC
Sbjct: 2445 DIPHQPMGII----AVANDTNSCELSPCALLNGGCHDLCLLTP-----NGRVNCSCRGDR 2495
Query: 741 NVEENGRDCQSTATTVTYSE 760
+ E+ R ++ YSE
Sbjct: 2496 ILLEDNRCVTKNSSCNAYSE 2515
Score = 103 bits (257), Expect = 7e-22
Identities = 67/210 (31%), Positives = 93/210 (44%), Gaps = 30/210 (14%)
Query: 21 ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK-NCVKKTCAESDFVC 79
E G C+ + F C N CI + CD D+DC DGSDE C + C +F C
Sbjct: 2793 ELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSC 2852
Query: 80 NNGQC-VPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGA-----HSTQCIPVSWR 133
+G+C + ++W+CDGD DC D SDE+P C+ E SC + + +CIP
Sbjct: 2853 ADGRCLLNTQWQCDGDFDCPDHSDEAPLN---PKCKSAEQSCNSSFFMCKNGRCIPSGGL 2909
Query: 134 CDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSD--GSDELDCAPP 191
CD ++DC G DE N C C+S+ V DC D S + C P
Sbjct: 2910 CDNKDDCGDGSDERN------------CHINECLSKK-VSGCSQDCQDLPVSYKCKCWP- 2955
Query: 192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQ 221
+ + +C+ I C CS Q
Sbjct: 2956 ---GFQLKDDGKTCVDID-ECSSGFPCSQQ 2981
Score = 73.9 bits (180), Expect = 6e-13
Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)
Query: 69 KKTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDES----PEQCHMRTCRIHEISCGAH 123
++ C +F+C++ CV W CDGDPDC D SDES PE+ ++ C ++ I+C
Sbjct: 29 QQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIK-CPLNHIAC-LG 86
Query: 124 STQCIPVSWRCDGENDCDSGEDE--------ENCGNITCSPDEFTCSSGRCISRNFVCNG 175
+ +C+ +S C+G DC G DE NC + C ++ C+ R +R + +G
Sbjct: 87 TNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC---QYKCTMVRNSTRCYCEDG 143
Query: 176 QDDCSDG---SDELDCA-----PPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLE 227
+ DG D+ +CA TC + T SC+ + D+ C +E
Sbjct: 144 FEITEDGRSCKDQDECAVYGTCSQTC-RNTHGSYTCSCVEGYLMQPDNRSCK----AKIE 198
Query: 228 QCGRQPVI 235
R P++
Sbjct: 199 PTDRPPIL 206
Score = 60.8 bits (146), Expect = 5e-09
Identities = 40/124 (32%), Positives = 56/124 (45%), Gaps = 9/124 (7%)
Query: 33 CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDEK--NC---VKKTCAESDFVC-NNGQCV 85
C+P +F C + C++ W CDGD DC D SDE C V+ C + C +CV
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
C+G DC DG DE C +++C T + S RC E+ + ED
Sbjct: 92 HLSQLCNGVLDCPDGYDEG-VHCQELLSNCQQLNCQYKCTM-VRNSTRCYCEDGFEITED 149
Query: 146 EENC 149
+C
Sbjct: 150 GRSC 153
Score = 48.9 bits (115), Expect = 2e-05
Identities = 41/144 (28%), Positives = 60/144 (41%), Gaps = 36/144 (25%)
Query: 23 GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC----VKKTCAES--- 75
G T + C+ +F C+N +CI + +CD +DC DGSDE+ C + TC ++
Sbjct: 3752 GGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNP 3811
Query: 76 ---DFVCNN------GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQ 126
D CN +C P + + CED + C + G S Q
Sbjct: 3812 CGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCED----------LNECLVF----GTCSHQ 3857
Query: 127 CIPV--SWRCDGENDCDSGEDEEN 148
CI V S++C CD E N
Sbjct: 3858 CINVEGSYKC----VCDQNFQERN 3877
Score = 36.2 bits (82), Expect = 0.14
Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 3/47 (6%)
Query: 350 EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRK--TC 394
+P K+ N C VNNGGCS +C + G C CA +L+D TC
Sbjct: 788 DPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADN-QLLDENGTTC 833
Score = 30.8 bits (68), Expect = 5.7
Identities = 32/117 (27%), Positives = 41/117 (35%), Gaps = 20/117 (17%)
Query: 666 AVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENG---GCEYLCLPA 722
A G NK L+ L N + D D Y E V C+E + N C+Y C
Sbjct: 83 ACLGTNKCV--HLSQLCNGVLDCPD--GYDEGVH------CQELLSNCQQLNCQYKCTMV 132
Query: 723 PQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDT-NTTEISATSGLVPG 778
C C G+ + E+GR C+ Y T T S T V G
Sbjct: 133 RNST------RCYCEDGFEITEDGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCVEG 183
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 252 bits (643), Expect = 1e-66
Identities = 148/407 (36%), Positives = 192/407 (47%), Gaps = 54/407 (13%)
Query: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
+C ++ C++G CI W CDGD DC D SDE NC + TC S+F C NG C+P RW
Sbjct: 1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRW 1216
Query: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
CDGD DC+DGSDE P C + C G CIP S CDG DC G DE++C
Sbjct: 1217 ACDGDTDCQDGSDEDPVNCE-KKCNGFRCPNGT----CIPSSKHCDGLRDCSDGSDEQHC 1271
Query: 150 GNITCSPDEFTCSS-GRCISRNFVCNGQDDCSDGSDE----LDCAP-----PTCGAHEFQ 199
+ +F C + +C+ + VC+G C DGSDE C+ C FQ
Sbjct: 1272 EPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQ 1331
Query: 200 CSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPA-SEIQCGSGECIHKKWRC 258
C CI + W CD DC D SDE+ C P C + +C +G CI +W+C
Sbjct: 1332 CQNGVCISLIWKCDGMDDCGDYSDEA--NC-ENPTEAPNCSRYFQFRCENGHCIPNRWKC 1388
Query: 259 DGDPDCKDGSDEVNC------------PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDG 306
D + DC D SDE +C PS TC P+ + C G+C+ + C+G RDC DG
Sbjct: 1389 DRENDCGDWSDEKDCGDSHILPFSTPGPS-TCLPNYYRCSSGTCVMDTWVCDGYRDCADG 1447
Query: 307 SDEVNC---KNVNQCLGPG--------KFKCRSGE-CIDISKVCNQEQDCRDWSDEPLKE 354
SDE C NV P +F+C + CI K C+ QDC+D DE
Sbjct: 1448 SDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCP 1507
Query: 355 CHIN-ECLVNNGGCSHICKDLVIGYECDCAAGF----ELIDRKTCGD 396
H C+ C +V+ CD GF + D K C D
Sbjct: 1508 THSTLTCMSREFQCEDGEACIVLSERCD---GFLDCSDESDEKACSD 1551
Score = 251 bits (641), Expect = 2e-66
Identities = 143/381 (37%), Positives = 182/381 (47%), Gaps = 71/381 (18%)
Query: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTC-AESDFVC-NNGQCVPSRWK 90
C +Q++C+NG CI +W CD D DC D SDE+NC C ++ F C +G C+P +K
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
Query: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
CD + DC D SDES C M CR E +C S CI SW CDG+NDC DE NC
Sbjct: 1138 CDLEDDCGDNSDES--HCEMHQCRSDEYNCS--SGMCIRSSWVCDGDNDCRDWSDEANCT 1193
Query: 151 NI--TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCI 206
I TC F C +G CI + + C+G DC DGSDE ++C G F+C +CI
Sbjct: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---FRCPNGTCI 1250
Query: 207 PISWVCDDDADCSDQSDE------------------------------------------ 224
P S CD DCSD SDE
Sbjct: 1251 PSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDA 1310
Query: 225 SLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPD--- 281
+ C + P H C QC +G CI W+CDG DC D SDE NC + T P+
Sbjct: 1311 AFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSR 1370
Query: 282 --QFECEDGSCIHGSRQCNGIRDCVDGSDEVNC----------KNVNQCLGPGKFKCRSG 329
QF CE+G CI +C+ DC D SDE +C + CL P ++C SG
Sbjct: 1371 YFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCL-PNYYRCSSG 1429
Query: 330 ECIDISKVCNQEQDCRDWSDE 350
C+ + VC+ +DC D SDE
Sbjct: 1430 TCVMDTWVCDGYRDCADGSDE 1450
Score = 230 bits (586), Expect = 5e-60
Identities = 137/381 (35%), Positives = 175/381 (45%), Gaps = 81/381 (21%)
Query: 57 DCVDGSDEKN--CVKK--TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRT 112
DC G KN CVK+ TC + + C+NG C+ S W CD D DC D SDE C
Sbjct: 1059 DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE--RNCPTTI 1116
Query: 113 CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFV 172
C + S CIP+S++CD E+DC DE +C C DE+ CSSG CI ++V
Sbjct: 1117 CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWV 1176
Query: 173 CNGQDDCSDGSDELDCAP--PTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCG 230
C+G +DC D SDE +C TC A FQC CIP W CD D DC D SDE C
Sbjct: 1177 CDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE 1236
Query: 231 RQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP---------------- 274
+ KC + +C +G CI CDG DC DGSDE +C
Sbjct: 1237 K------KC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQ 1288
Query: 275 ---------------------------------SRTCRPDQFECEDGSCIHGSRQCNGIR 301
+ C F+C++G CI +C+G+
Sbjct: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
Query: 302 DCVDGSDEVNCKNVNQ---CLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC--- 355
DC D SDE NC+N + C +F+C +G CI C++E DC DWSDE K+C
Sbjct: 1349 DCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE--KDCGDS 1406
Query: 356 HI--------NECLVNNGGCS 368
HI + CL N CS
Sbjct: 1407 HILPFSTPGPSTCLPNYYRCS 1427
Score = 154 bits (388), Expect = 4e-37
Identities = 94/328 (28%), Positives = 159/328 (48%), Gaps = 26/328 (7%)
Query: 434 CKAVGKEPSLIFTNRRDIRKIGLERKEYIQL-VEQLRNTVALDADIAAQKLFWADLSQKA 492
C + +++ R+ I + L QL + LR VALD D L+W+DL+
Sbjct: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811
Query: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFN 552
I ++ G+ V + + A+A + + + +YW DA K I VA DG R + N
Sbjct: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
Query: 553 SD-LREPASIAVDPLSGFVYWSDWGE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
S L P ++ + P G ++W+DWG+ I ++ M+G LV+ D++WPNGI++D
Sbjct: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
Query: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGA 670
+YW D+ L + + +GQ R ++L + L HP A+ +F++ +YW D +++ A
Sbjct: 930 DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHPYAIAVFKNEIYWDDWSQLSIFRA 986
Query: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDH-- 728
+K++GS++ L N L D+ ++++ GKN C LCLP +
Sbjct: 987 SKYSGSQMEILANQLTGLMDMKIFYK-----GKNTGSNACVPRPCSLLCLPKANNSRSCR 1041
Query: 729 -----------SPKYTCSCPSGYNVEEN 745
S C CP GY ++ N
Sbjct: 1042 CPEDVSSSVLPSGDLMCDCPQGYQLKNN 1069
Score = 65.9 bits (159), Expect = 2e-10
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 5/106 (4%)
Query: 32 KCEPSQFQCTNGRCITLLWK-CDGDEDCVDGSDEKNCVKK---TCAESDFVCNNGQ-CVP 86
+C+ +F+C + WK CDG +DC DG DE NC TC +F C +G+ C+
Sbjct: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIV 1529
Query: 87 SRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSW 132
+CDG DC D SDE + ++ + A + + ++W
Sbjct: 1530 LSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTW 1575
>gi|119709832 low density lipoprotein receptor-related protein 5
[Homo sapiens]
Length = 1615
Score = 248 bits (634), Expect = 1e-65
Identities = 128/320 (40%), Positives = 196/320 (61%), Gaps = 13/320 (4%)
Query: 441 PSLIFTNRRDIRKI--GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASI 498
P L+F NRRD+R + G + E +V L + A+D + ++W D+S++AI +
Sbjct: 33 PLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYL 92
Query: 499 DDKVGRHVK--MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR 556
+ + G V+ +I + +P +A DWV K +YWTD+ + I VA L+GT RK LF DL
Sbjct: 93 N-QTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLD 151
Query: 557 EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616
+P +IA+DP G++YW+DWGE +IE+AGM+G R+ +V +DI WPNG+T+DL + +LYW
Sbjct: 152 QPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYW 211
Query: 617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGS 676
D+KL + +L+G R+ V++ L HP ALT+ D +YW D + +++ NK TG
Sbjct: 212 ADAKLSFIHRANLDGSFRQKVVEG--SLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG 269
Query: 677 ELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
+ +++ L DI V + QP CEED NGGC +LCL +P P YTC+C
Sbjct: 270 KRKEILSALYSPMDIQVLSQERQPFFHTRCEED--NGGCSHLCLLSPS----EPFYTCAC 323
Query: 737 PSGYNVEENGRDCQSTATTV 756
P+G +++NGR C++ A V
Sbjct: 324 PTGVQLQDNGRTCKAGAEEV 343
Score = 208 bits (530), Expect = 2e-53
Identities = 128/407 (31%), Positives = 206/407 (50%), Gaps = 32/407 (7%)
Query: 401 QNPGICSQICINLKGG--YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
++ G CS +C+ Y C C G Q+ CKA G E L+ R D+R+I L+
Sbjct: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-GAEEVLLLARRTDLRRISLDT 359
Query: 459 KEYIQLVEQ---LRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
++ +V Q +R+ +A+D D ++W D +AI A +D G + + +P
Sbjct: 360 PDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGS-GAQTLVNTEINDP 418
Query: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
IAVDWV + +YWTD + I V L+GT RK L + DL EP +IA+ P+ G +YW+DW
Sbjct: 419 DGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDW 478
Query: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
GE KIE A ++G +RR LV A + WPNG+ LDL + +LYW D+K + ++++G RR
Sbjct: 479 GENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRR 538
Query: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
+L+ + L H T+ D +YW D + ++ +K S +++ L D + +
Sbjct: 539 TLLE--DKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVN 595
Query: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATT 755
+ + G N C + NGGC +LC P H+ + C CP G + + + C
Sbjct: 596 -VAKVVGTNPCAD--RNGGCSHLCFFTP----HATR--CGCPIGLELLSDMKTCIVPEAF 646
Query: 756 VTYSETKDTNTTEISATSGLVPGGINVTTAVSEVSVPPKGTSAAWAI 802
+ + TS I++ T ++V++P G A A+
Sbjct: 647 LVF-------------TSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
Score = 193 bits (491), Expect = 5e-49
Identities = 128/423 (30%), Positives = 193/423 (45%), Gaps = 67/423 (15%)
Query: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
N C NGGCSH+C C C G EL+ D KTC
Sbjct: 603 NPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC---------------------- 640
Query: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLE--RKEYIQLVEQLRNTVAL 474
+ E L+FT+R I +I LE + + ++ AL
Sbjct: 641 --------------------IVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
Query: 475 DADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS 534
D D++ ++W D+S K I A ++ HV Y P +AVDW+ K +YW D +
Sbjct: 681 DFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDY-PEGMAVDWMGKNLYWADTGT 739
Query: 535 KTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPL 594
I VA LDG R+ L DL P S+A+DP G++YW++WG +I +A M+G + L
Sbjct: 740 NRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTL 799
Query: 595 VTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFE 654
V + N +T+D RLYW D +M+ S ++ GQ+R ++ + L HP LT +
Sbjct: 800 VD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFGLTQYS 855
Query: 655 DRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGG 714
D +YW D ++ A+K +G + +L+ DI+V+H Q G N C + NG
Sbjct: 856 DYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ-DGLNDCMHN--NGQ 912
Query: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSG 774
C LCL P + C C S Y ++ + R+C T + +S+ SA S
Sbjct: 913 CGQLCLAIP------GGHRCGCASHYTLDPSSRNCSPPTTFLLFSQK--------SAISR 958
Query: 775 LVP 777
++P
Sbjct: 959 MIP 961
Score = 135 bits (341), Expect = 1e-31
Identities = 98/368 (26%), Positives = 177/368 (48%), Gaps = 22/368 (5%)
Query: 397 IDECQ-NPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
+++C N G C Q+C+ + GG++C C+ Y +D ++ C L+F+ + I ++
Sbjct: 903 LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSP--PTTFLLFSQKSAISRMI 960
Query: 456 LERKEYIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512
+ + L+ LRN A+D D + ++W D Q I A D + +
Sbjct: 961 PDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTSLSQG 1019
Query: 513 YNPAA----IAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSG 568
NP +++D +T++WT A+ TI+V L G + D +P +I V+ G
Sbjct: 1020 QNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERG 1079
Query: 569 FVYWSDWGE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
++Y+++ + AKIE+A ++G +R L T + P + +D +L+W+D+ L + S
Sbjct: 1080 YLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESC 1139
Query: 628 DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
DL+G + R+ L+ + PL LTI +YWID + + + K TG + + +
Sbjct: 1140 DLSGAN-RLTLEDAN-IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAH 1197
Query: 688 AQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENG 746
I E+ ++ + C D NGGC ++C+ D +P+ CSCP + +N
Sbjct: 1198 LTGIHAVEEVSLEEFSAHPCARD--NGGCSHICIAK---GDGTPR--CSCPVHLVLLQNL 1250
Query: 747 RDCQSTAT 754
C T
Sbjct: 1251 LTCGEPPT 1258
Score = 119 bits (299), Expect = 9e-27
Identities = 56/126 (44%), Positives = 76/126 (60%), Gaps = 12/126 (9%)
Query: 190 PPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
PPTC +F C+T CIP +W CD +C DQSDE E C PV C A++ C
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGC---PV----CSAAQFPCA 1306
Query: 248 SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
G+C+ + RCDG+ DC+D SDE +C + C P+QF C G C+ +QC+ DC+DGS
Sbjct: 1307 RGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGS 1365
Query: 308 DEVNCK 313
DE+ C+
Sbjct: 1366 DELMCE 1371
Score = 105 bits (263), Expect = 1e-22
Identities = 55/133 (41%), Positives = 72/133 (54%), Gaps = 11/133 (8%)
Query: 224 ESLEQCGRQPVIHTKCPASEIQCGSGE--CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPD 281
++L CG P C + C +GE CI WRCDG P+C D SDE CP C
Sbjct: 1248 QNLLTCGEPPT----CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAA 1301
Query: 282 QFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQE 341
QF C G C+ +C+G DC D SDE +C + CL P +F+C SG+C+ I + C+
Sbjct: 1302 QFPCARGQCVDLRLRCDGEADCQDRSDEADCDAI--CL-PNQFRCASGQCVLIKQQCDSF 1358
Query: 342 QDCRDWSDEPLKE 354
DC D SDE + E
Sbjct: 1359 PDCIDGSDELMCE 1371
Score = 105 bits (262), Expect = 2e-22
Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 3/122 (2%)
Query: 112 TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNF 171
TC + +C CIP +WRCDG +CD DEE C CS +F C+ G+C+
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCVDLRL 1315
Query: 172 VCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGR 231
C+G+ DC D SDE DC C ++F+C++ C+ I CD DC D SDE + + +
Sbjct: 1316 RCDGEADCQDRSDEADC-DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITK 1374
Query: 232 QP 233
P
Sbjct: 1375 PP 1376
Score = 98.2 bits (243), Expect = 3e-20
Identities = 53/133 (39%), Positives = 68/133 (51%), Gaps = 10/133 (7%)
Query: 28 GRKAKCEPSQFQCTNGR--CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCV 85
G C P QF C G CI W+CDG +C D SDE+ C C+ + F C GQCV
Sbjct: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCARGQCV 1311
Query: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
R +CDG+ DC+D SDE+ C C ++ C S QC+ + +CD DC G D
Sbjct: 1312 DLRLRCDGEADCQDRSDEA--DCD-AICLPNQFRCA--SGQCVLIKQQCDSFPDCIDGSD 1366
Query: 146 EENCGNITCSPDE 158
E C IT P +
Sbjct: 1367 ELMC-EITKPPSD 1378
Score = 33.1 bits (74), Expect = 1.2
Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 2/51 (3%)
Query: 352 LKECHINECLVNNGGCSHICKDLVIGY-ECDCAAGFELIDR-KTCGDIDEC 400
L+E + C +NGGCSHIC G C C L+ TCG+ C
Sbjct: 1209 LEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTC 1259
>gi|148727288 low density lipoprotein receptor-related protein 6
[Homo sapiens]
Length = 1613
Score = 244 bits (624), Expect = 2e-64
Identities = 121/328 (36%), Positives = 195/328 (59%), Gaps = 10/328 (3%)
Query: 429 LATGVCKAVGKEPSLIFTNRRDIRKIGLE--RKEYIQLVEQLRNTVALDADIAAQKLFWA 486
LA C + P L++ NRRD+R + ++ +V L + A+D + ++W+
Sbjct: 9 LACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWS 68
Query: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
D+S++AI + ++ + +P +A DW+ + +YWTD+ + I V+ LDG+
Sbjct: 69 DVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSL 128
Query: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
RK LF +L +P +IA+DP SGF+YW+DWGE KIE+AGM+G R ++ ++I WPNG+T
Sbjct: 129 RKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLT 188
Query: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
LD + +LYW D+KL+ + +L+G +R+ V+K L HP ALT+FED +YW D +
Sbjct: 189 LDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKG--SLPHPFALTLFEDILYWTDWSTHS 246
Query: 667 VYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQIN 726
+ NK+TG L + +++ DI + + QP+ N C ++NGGC +LCL +P
Sbjct: 247 ILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPC--GIDNGGCSHLCLMSPV-- 302
Query: 727 DHSPKYTCSCPSGYNVEENGRDCQSTAT 754
P Y C+CP+G + ENG+ C+ AT
Sbjct: 303 --KPFYQCACPTGVKLLENGKTCKDGAT 328
Score = 222 bits (566), Expect = 1e-57
Identities = 132/411 (32%), Positives = 197/411 (47%), Gaps = 58/411 (14%)
Query: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
N C NGGCSH+C G C C GFELI D KTC
Sbjct: 590 NPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC---------------------- 627
Query: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLV--EQLRNTVAL 474
+ E L+F+ R DIR+I LE + ++ AL
Sbjct: 628 --------------------IVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASAL 667
Query: 475 DADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS 534
D D+ +++W D+S K I A ++ HV Y P +AVDW+ K +YW D +
Sbjct: 668 DFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDY-PEGMAVDWLGKNLYWADTGT 726
Query: 535 KTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPL 594
I V+ LDG R+ L DL P ++A+DP GF+YW++WG KI++A M+G +R L
Sbjct: 727 NRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTL 786
Query: 595 VTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFE 654
V ++ NG+T+D K RLYW D +++ S ++ G +R ++ + L HP LT ++
Sbjct: 787 V-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFGLTQYQ 842
Query: 655 DRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGG 714
D +YW D ++ ANK +G + +L+ DI+V+H Q SG N C NG
Sbjct: 843 DYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECAS--SNGH 899
Query: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTN 765
C +LCL P + C CP+ Y++ + R C + T + +S+ N
Sbjct: 900 CSHLCLAVP-----VGGFVCGCPAHYSLNADNRTCSAPTTFLLFSQKSAIN 945
Score = 216 bits (550), Expect = 7e-56
Identities = 133/453 (29%), Positives = 215/453 (47%), Gaps = 77/453 (16%)
Query: 358 NECLVNNGGCSHIC--KDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLK 414
N C ++NGGCSH+C + Y+C C G +L++ KTC D
Sbjct: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325
Query: 415 GGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLV---EQLRNT 471
G L+ R D+R+I L+ ++ +V E +R+
Sbjct: 326 -----------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHA 362
Query: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
+A+D D ++W D +AI + ID G + + +P IAVDWV + +YWTD
Sbjct: 363 IAIDYDPVEGYIYWTDDEVRAIRRSFIDGS-GSQFVVTAQIAHPDGIAVDWVARNLYWTD 421
Query: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
+ I V L+GT RK L + DL EP +I +DP+ G++YW+DWGE KIE+A ++G DR
Sbjct: 422 TGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDR 481
Query: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALT 651
LV + WPNG+ LD + ++YW D+K + ++ +G RR++++ + + H T
Sbjct: 482 VVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHIFGFT 539
Query: 652 IFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIV--YHELVQPSGKNWCEED 709
+ D VYW D + ++ +K +E +++ L D + H ++ G N C E
Sbjct: 540 LLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI---GSNPCAE- 594
Query: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEI 769
ENGGC +LCL PQ C+CP G+ + + + C + +S D
Sbjct: 595 -ENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRR--- 644
Query: 770 SATSGLVPGGINVTTAVSEVSVPPKGTSAAWAI 802
I++ T + V++P G A A+
Sbjct: 645 ----------ISLETNNNNVAIPLTGVKEASAL 667
Score = 143 bits (361), Expect = 6e-34
Identities = 107/354 (30%), Positives = 179/354 (50%), Gaps = 27/354 (7%)
Query: 398 DECQNP-GICSQICINLK-GGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
+EC + G CS +C+ + GG+ C C Y ++ C A L+F+ + I ++
Sbjct: 891 NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSA--PTTFLLFSQKSAINRMV 948
Query: 456 LERKE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512
++ ++ I + LRN A+D D ++L+W D Q I A D G V ++ +V
Sbjct: 949 IDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTV-VVSSV 1007
Query: 513 ------YNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPL 566
P +++D + IYWT A+ I+V LDG + + P ++ V+P
Sbjct: 1008 PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPE 1067
Query: 567 SGFVYWSDWGEPA-KIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLS 625
G++Y+++ E + KIE+A ++G +R L + + P + LD +L+W DS L +
Sbjct: 1068 KGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIE 1127
Query: 626 SVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVN-N 684
S DL+G + RIVL+ L P+ LT+FE+ +YWID + + + + TG E T V
Sbjct: 1128 SSDLSGAN-RIVLEDSNIL-QPVGLTVFENWLYWIDKQQQMIEKID-MTGREGRTKVQAR 1184
Query: 685 LNDAQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
+ DI EL +Q ++ C +D NGGC ++CL D + + CSCP
Sbjct: 1185 IAQLSDIHAVKELNLQEYRQHPCAQD--NGGCSHICLVK---GDGTTR--CSCP 1231
Score = 115 bits (287), Expect = 2e-25
Identities = 60/132 (45%), Positives = 75/132 (56%), Gaps = 13/132 (9%)
Query: 184 DELDCA-PPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240
DEL C PPTC +F C T CIP++W CD +C D SDE C PV C
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL--NC---PV----CS 1289
Query: 241 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300
S+ QC SG+CI RC+GD +C+D SDE NC C DQF C +G CI ++C+
Sbjct: 1290 ESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCDHN 1348
Query: 301 RDCVDGSDEVNC 312
DC D SDE++C
Sbjct: 1349 VDCSDKSDELDC 1360
Score = 108 bits (270), Expect = 2e-23
Identities = 55/124 (44%), Positives = 71/124 (57%), Gaps = 11/124 (8%)
Query: 229 CGRQPVIHTKCPASEIQCGSGE--CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE 286
CG P C + C +GE CI WRCDG +C+D SDE+NCP C QF+C
Sbjct: 1243 CGEPPT----CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296
Query: 287 DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRD 346
G CI G+ +CNG +C D SDE NC+ + CL +F+C +G+CI K C+ DC D
Sbjct: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVL--CL-IDQFRCANGQCIGKHKKCDHNVDCSD 1353
Query: 347 WSDE 350
SDE
Sbjct: 1354 KSDE 1357
Score = 107 bits (268), Expect = 4e-23
Identities = 62/159 (38%), Positives = 85/159 (53%), Gaps = 17/159 (10%)
Query: 42 NGRCITL-LWKCDGDEDC------VDGSDEKNCVKK-TCAESDFVCNNGQ--CVPSRWKC 91
NG C + L K DG C V DE +C + TC+ F C G+ C+P W+C
Sbjct: 1211 NGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRC 1270
Query: 92 DGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGN 151
DG +CED SDE + C + C S QCI + RC+G+ +C DE+NC
Sbjct: 1271 DGFTECEDHSDE----LNCPVCSESQFQCA--SGQCIDGALRCNGDANCQDKSDEKNC-E 1323
Query: 152 ITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAP 190
+ C D+F C++G+CI ++ C+ DCSD SDELDC P
Sbjct: 1324 VLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYP 1362
Score = 99.4 bits (246), Expect = 1e-20
Identities = 50/124 (40%), Positives = 66/124 (53%), Gaps = 9/124 (7%)
Query: 28 GRKAKCEPSQFQCTNGR--CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCV 85
G C P QF C G CI + W+CDG +C D SDE NC C+ES F C +GQC+
Sbjct: 1244 GEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PVCSESQFQCASGQCI 1301
Query: 86 PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
+C+GD +C+D SDE + C + C I + C + QCI +CD DC D
Sbjct: 1302 DGALRCNGDANCQDKSDE--KNCEV-LCLIDQFRCA--NGQCIGKHKKCDHNVDCSDKSD 1356
Query: 146 EENC 149
E +C
Sbjct: 1357 ELDC 1360
Score = 34.7 bits (78), Expect = 0.40
Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 6/53 (11%)
Query: 352 LKECHINECLVNNGGCSHICKDLVIG---YECDCAAGFELI-DRKTCGDIDEC 400
L+E + C +NGGCSHIC LV G C C L+ D +CG+ C
Sbjct: 1199 LQEYRQHPCAQDNGGCSHIC--LVKGDGTTRCSCPMHLVLLQDELSCGEPPTC 1249
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 217 bits (552), Expect = 4e-56
Identities = 146/489 (29%), Positives = 231/489 (47%), Gaps = 43/489 (8%)
Query: 272 NCPSRTCRPDQFE----CEDGSCIHGSRQ-CNGIRDCV--DGSDEVNCKNVNQCLGPGKF 324
NC S C D C +G + R+ C + +C + + CKN PG +
Sbjct: 324 NCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNT-----PGSY 378
Query: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECH-INECLVNNGGCSHICKDLVIGYECDCA 383
C + V + K CH + C N CSH C G C C
Sbjct: 379 YCTC----PVGFVLLPDG----------KRCHQLVSCPRNVSECSHDCVLTSEGPLCFCP 424
Query: 384 AGFELI-DRKTCGDIDECQNPGICSQICINLKG-GYKCECSRGYQMDLATGVCKAVGKEP 441
G L D KTC N G CSQ+C+ L ++C+C GY + L C A G +P
Sbjct: 425 EGSVLERDGKTCSGCSSPDNGG-CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQP 483
Query: 442 SLIFTNRRDIRKIGLERKEYIQLVEQLRNTV-ALDADIAAQKLFWADLSQKAIFSASIDD 500
L+F N +DIR + + +Y L+ Q V ALD D K+++A + K I A++D
Sbjct: 484 FLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDG 543
Query: 501 KVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPAS 560
R + + V P +AVDW+ + YWTD I + L+G + K + ++ +P
Sbjct: 544 SQ-RERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRG 602
Query: 561 IAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSK 620
IAV P++ ++W+D G +IE + + G R + ++D+ WP+GIT+D + +LYW D+K
Sbjct: 603 IAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662
Query: 621 LHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELAT 680
++ +L+G RR + ++ + HP A+ +FED V++ D +V NK TG +
Sbjct: 663 QSVIEMANLDGSKRRRLTQN--DVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR 720
Query: 681 LVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
L ++ ++V H L +P G + C +NGGCE++C CSC G+
Sbjct: 721 LQGSMLKPSSLVVVHPLAKP-GADPCL--YQNGGCEHIC------KKRLGTAWCSCREGF 771
Query: 741 NVEENGRDC 749
+G+ C
Sbjct: 772 MKASDGKTC 780
Score = 105 bits (263), Expect = 1e-22
Identities = 81/357 (22%), Positives = 158/357 (44%), Gaps = 36/357 (10%)
Query: 411 INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRN 470
++L C G C VG P LIF++ I +I E Y QLV
Sbjct: 18 VSLSAPQHWSCPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV 75
Query: 471 TVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWT 530
+V +D ++++W DL ++ + ++ V I+ N + +A++W+ + + W+
Sbjct: 76 SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEK--NVSGMAINWINEEVIWS 133
Query: 531 DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFD 590
+ I+V + G L S L+ PA++AVDP+ F++WS + +A ++G
Sbjct: 134 NQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVG 191
Query: 591 RRPLVTADIQWPNGITLDLIKSRLYWL----DSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
+ L+ + ++LD++ RL+W+ + ++ S D +G S+ H
Sbjct: 192 VKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-------GSVHISKH 243
Query: 647 P-----LALTIFEDRVYWIDGENEAVYGANKFTGSELA--TLVNNLNDAQDIIVYHELVQ 699
P A+++F DR+++ + + ++ ANK TG ++ L ++ ++ V H L Q
Sbjct: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQ 303
Query: 700 PSGKN--WCEED----MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
P ++ W E + G C + + C C GY + + + C+
Sbjct: 304 PKAEDDTWEPEQKLCKLRKGNCS-----STVCGQDLQSHLCMCAEGYALSRDRKYCE 355
Score = 53.5 bits (127), Expect = 8e-07
Identities = 31/69 (44%), Positives = 37/69 (53%), Gaps = 7/69 (10%)
Query: 366 GCSHICKDLVIGYE--CDCAAGFELIDRKTCGDIDECQ-NPGIC---SQICINLKGGYKC 419
GCS + + G + C C GF D K C DIDEC+ +C S CIN +GGY C
Sbjct: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSKCINTEGGYVC 897
Query: 420 ECSRGYQMD 428
CS GYQ D
Sbjct: 898 RCSEGYQGD 906
Score = 42.7 bits (99), Expect = 0.001
Identities = 35/124 (28%), Positives = 52/124 (41%), Gaps = 21/124 (16%)
Query: 305 DGSDEVNCKNVNQCLGPGK---FKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECL 361
D V C +C+ G+ +C G D K+C+ +C P+ ++C+
Sbjct: 833 DDCAPVGCSMYARCISEGEDATCQCLKGFAGD-GKLCSDIDECE--MGVPVCPPASSKCI 889
Query: 362 VNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQ-NPGICSQ--ICINLKGGYK 418
GG Y C C+ G++ D C DIDECQ C + C N +GGY
Sbjct: 890 NTEGG-----------YVCRCSEGYQG-DGIHCLDIDECQLGEHSCGENASCTNTEGGYT 937
Query: 419 CECS 422
C C+
Sbjct: 938 CMCA 941
Score = 41.6 bits (96), Expect = 0.003
Identities = 21/49 (42%), Positives = 26/49 (53%), Gaps = 1/49 (2%)
Query: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGF-ELIDRKTCGDID 398
PL + + CL NGGC HICK + C C GF + D KTC +D
Sbjct: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALD 784
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 181 bits (458), Expect = 3e-45
Identities = 106/319 (33%), Positives = 139/319 (43%), Gaps = 63/319 (19%)
Query: 33 CEPSQFQCT-NGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKC 91
C + C NG C+ W CD +DC DGSDE+ C C E C++G C+P C
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLC 1435
Query: 92 DGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC-G 150
D DC DG+DE C ++C +C+P + CDG DC DEE+C G
Sbjct: 1436 DRQDDCGDGTDEPSYPCPQGL-----LACA--DGRCLPPALLCDGHPDCLDAADEESCLG 1488
Query: 151 NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE------------------------- 185
+TC P E +C G C+ +C+G DC DG+DE
Sbjct: 1489 QVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGS 1548
Query: 186 LDCA---------PPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH 236
LD A P CG EF+C + C P W CD + DC+D SDE CG
Sbjct: 1549 LDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDE--RGCG------ 1600
Query: 237 TKCPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDE----------VNCPSRTCRP-DQFE 284
C C G C+ + CDG C DGSDE + P+RT P ++
Sbjct: 1601 GPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYT 1660
Query: 285 CEDGSCIHGSRQCNGIRDC 303
C +G+CI C+G DC
Sbjct: 1661 CPNGTCIGFQLVCDGQPDC 1679
Score = 161 bits (408), Expect = 2e-39
Identities = 96/319 (30%), Positives = 135/319 (42%), Gaps = 75/319 (23%)
Query: 95 PDCEDGSDESPEQCHMRTCRIHEISCGA----HSTQCI-PVSWRCD-GENDCDSGED-EE 147
P C + E C + C + C H C+ P S C+ G N G ++
Sbjct: 1290 PTCHEQHPEPGWHCQVVAC-VEGCFCPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQK 1348
Query: 148 NCGNITCSPDEFTCS----------------------SGRCISRNFVCNGQDDCSDGSDE 185
+CGN TC ++ C +G C+ ++C+ QDDC DGSDE
Sbjct: 1349 DCGNCTCQEGQWHCGGDGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDE 1408
Query: 186 LDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQ 245
CA P CG + CS+ C+P++ +CD DC D +DE CP +
Sbjct: 1409 EGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEP----------SYPCPQGLLA 1458
Query: 246 CGSGECIHKKWRCDGDPDCKDGSDEVNCPSR-TCRPDQFECEDGSCIHGSRQCNGIRDCV 304
C G C+ CDG PDC D +DE +C + TC P + C DG+C+ + C+G+ DC
Sbjct: 1459 CADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCP 1518
Query: 305 DGSDE---------------------------------VNCKNVNQCLGPGKFKCRSGEC 331
DG+DE + C GP +F+C SGEC
Sbjct: 1519 DGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPC-GPFEFRCGSGEC 1577
Query: 332 IDISKVCNQEQDCRDWSDE 350
C+QE+DC D SDE
Sbjct: 1578 TPRGWRCDQEEDCADGSDE 1596
Score = 67.0 bits (162), Expect = 7e-11
Identities = 83/351 (23%), Positives = 118/351 (33%), Gaps = 59/351 (16%)
Query: 21 ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCN 80
+S A G +C P Q C C+ CDG EDC+DGSDE++C +
Sbjct: 2379 QSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLP---- 2434
Query: 81 NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140
+P+ W P C ++SCG S +C+ RCD DC
Sbjct: 2435 ---SLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCG--SGECLSAERRCDLRPDC 2489
Query: 141 DSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC 200
G DE+ C + +P S R Q+ C P C
Sbjct: 2490 QDGSDEDGCVDCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGSC--PRDRFRSQSC 2547
Query: 201 STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDG 260
+C P++ G + P S + CG G + R
Sbjct: 2548 FVQAC-PVA--------------------GAWAMWEAWGPCS-VSCGGGH--QSRQRSCV 2583
Query: 261 DPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQ--- 317
DP K+G CP + ++ C G + C+G DC G V+ +
Sbjct: 2584 DPPPKNGG--APCPGAS--QERAPC-------GLQPCSGGTDCELGRVYVSADLCQKGLV 2632
Query: 318 ------CLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLV 362
CL P + SG C++ + C D PL EC CLV
Sbjct: 2633 PPCPPSCLDPKANRSCSGHCVEGCR-CPPGLLLHDTRCLPLSEC---PCLV 2679
Score = 63.9 bits (154), Expect = 6e-10
Identities = 72/290 (24%), Positives = 99/290 (34%), Gaps = 89/290 (30%)
Query: 97 CEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSP 156
CE GS +P C + C S +C+ CDG DC+ G DEE C +
Sbjct: 2224 CEPGSPPAP------LCPGVGLRCA--SGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGT 2275
Query: 157 DEFTCSSGRCISRNFVCNGQ--DDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDD 214
F S+ + ++ + GQ +G E + PP E S + P+S
Sbjct: 2276 GRFH-STAKTLALSSAQPGQLLHWPREGLAETEHWPP---GQESPTSPTETRPVS---PG 2328
Query: 215 DADCSDQSDESLEQCGRQPV-------------------IHTKCPAS------------E 243
A ES++ P+ H PA+
Sbjct: 2329 PASGVPHHGESVQMVTTTPIPQMEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPP 2388
Query: 244 IQCGSGE-------CIHKKWRCDGDPDCKDGSDEVNC--------PS------------- 275
+QCG G+ C+ + CDG DC DGSDE +C PS
Sbjct: 2389 VQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFM 2448
Query: 276 -------------RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
C P Q C G C+ R+C+ DC DGSDE C
Sbjct: 2449 MPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498
Score = 40.0 bits (92), Expect = 0.009
Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 6/61 (9%)
Query: 264 CKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGK 323
C+ GS P+ C C G C+ C+G+ DC DGSDE C + + G G+
Sbjct: 2224 CEPGSP----PAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPE--GTGR 2277
Query: 324 F 324
F
Sbjct: 2278 F 2278
Score = 39.3 bits (90), Expect = 0.016
Identities = 16/36 (44%), Positives = 20/36 (55%)
Query: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV 68
C +C +G C+ CDG DC DGSDE+ CV
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCV 2269
Score = 37.4 bits (85), Expect = 0.061
Identities = 66/316 (20%), Positives = 97/316 (30%), Gaps = 77/316 (24%)
Query: 66 NCVKKTCAESDFVCNNGQC-VPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHS 124
NC + C + + +C G C +P W D S S + R S
Sbjct: 2694 NCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCDRSCGSGVRARFR------------S 2741
Query: 125 TQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEF---------TCSSGRCI-------- 167
P +W G C+ E + C + F +CS C+
Sbjct: 2742 PSNPPAAW---GGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSCSQS-CLAPGGGPGW 2797
Query: 168 -SRNFVCNGQDDCS---DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSD 223
SR+ +C D S D + E C+PP C + S CD +S
Sbjct: 2798 RSRSRLCPSPGDSSCPGDATQEEPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSC 2857
Query: 224 ESL--------------EQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSD 269
SL C QP +CP + + + +C + C C
Sbjct: 2858 SSLAPGDTTCPGPHSQTRDCNTQPCT-AQCPENMLFRSAEQCHQEGGPC--PRLCLTQGP 2914
Query: 270 EVNC-----PSRTCRPDQFECEDGSC---------IHGSRQCNGIRDCVDGSDEVNCKNV 315
+ C P TC P F + SC +HG +G +D + C +
Sbjct: 2915 GIECTGFCAPGCTCPPGLF-LHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVS- 2972
Query: 316 NQCLGPGKFKCRSGEC 331
GK C S C
Sbjct: 2973 ------GKMACTSERC 2982
Score = 36.2 bits (82), Expect = 0.14
Identities = 15/25 (60%), Positives = 17/25 (68%)
Query: 79 CNNGQCVPSRWKCDGDPDCEDGSDE 103
C +G+CV CDG DCEDGSDE
Sbjct: 2241 CASGECVLRGGPCDGVLDCEDGSDE 2265
Score = 34.7 bits (78), Expect = 0.40
Identities = 49/206 (23%), Positives = 71/206 (34%), Gaps = 46/206 (22%)
Query: 186 LDCAP-----PTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPV----IH 236
L C P P C +C++ C+ CD DC D SDE E C P H
Sbjct: 2222 LGCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDE--EGCVLLPEGTGRFH 2279
Query: 237 TKCPASEIQCGS-GECIHKKWRCDGDPDCK---DGSDEVNCPSRTCRPDQFECEDGSCIH 292
+ + G+ +H W +G + + G + P+ T RP G H
Sbjct: 2280 STAKTLALSSAQPGQLLH--WPREGLAETEHWPPGQESPTSPTET-RPVSPGPASGVPHH 2336
Query: 293 GSR---------QCNGIRDCVDGSDEVN---------CKNVNQCLGPGKF---KCRSGE- 330
G R G V Q + PG F +C G+
Sbjct: 2337 GESVQMVTTTPIPQMEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQT 2396
Query: 331 ------CIDISKVCNQEQDCRDWSDE 350
C++ ++VC+ +DC D SDE
Sbjct: 2397 PCEVLGCVEQAQVCDGREDCLDGSDE 2422
Score = 33.9 bits (76), Expect = 0.68
Identities = 40/200 (20%), Positives = 67/200 (33%), Gaps = 35/200 (17%)
Query: 96 DCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCD-----GENDCDSGEDEENCG 150
D ++G +Q + CR + S C+P+ CD G + + ++ C
Sbjct: 4081 DLQEGIVCQDDQVCQKGCRCPKGSL-EQDGGCVPIG-HCDCTDAQGHSWAPGSQHQDACN 4138
Query: 151 NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISW 210
N +C + +C++ C S S C+ +CG Q S SW
Sbjct: 4139 NCSCQAGQLSCTAQPCPPPTHCA-----WSHWSAWSPCS-HSCGPRGQQSRFRSSTSGSW 4192
Query: 211 VCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
+C ++ +S QP CP +Q + W +
Sbjct: 4193 A----PECREEQSQS------QPCPQPSCPPLCLQGTRSRTLGDSWL------------Q 4230
Query: 271 VNCPSRTCRPDQFECEDGSC 290
C +C P+ CED C
Sbjct: 4231 GECQRCSCTPEGVICEDTEC 4250
Score = 32.0 bits (71), Expect = 2.6
Identities = 21/63 (33%), Positives = 28/63 (44%), Gaps = 6/63 (9%)
Query: 715 CEYLCLPAPQI-NDHSPKYTCSCPSGYNVEENGRDCQSTATTVT-----YSETKDTNTTE 768
C P P I +P TCS P ++ GR C S A T +S+T+D NT
Sbjct: 2822 CSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAPGDTTCPGPHSQTRDCNTQP 2881
Query: 769 ISA 771
+A
Sbjct: 2882 CTA 2884
Score = 31.6 bits (70), Expect = 3.4
Identities = 68/296 (22%), Positives = 93/296 (31%), Gaps = 51/296 (17%)
Query: 133 RCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQD-----DCSDGSDELD 187
R DG N C E NC ++ C C + C GQ C+ + +
Sbjct: 3384 RPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHG 3443
Query: 188 CAPPTCGAHEF-------QCSTSSCIPIS-----WVCDDDAD-CSDQSDESLEQCGRQPV 234
AP T A E C + + P+ W D C QS S C R P
Sbjct: 3444 GAPCTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDMCLGQSHRS-RACSRPPT 3502
Query: 235 IH--TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIH 292
CP + Q S C +C DC G C R Q C
Sbjct: 3503 PEGGRPCPGNHTQ--SRPCQENSTQC---TDCGGGQSLHPCGQPCPRSCQDLSPGSVCQP 3557
Query: 293 GSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDEP 351
GS C C G C+ P +C+ + I + ++ R S E
Sbjct: 3558 GSVGCQPTCGCPLG----QLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWES 3613
Query: 352 LKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICS 407
L+ V G C + C C AG C ++ +C +PG+ S
Sbjct: 3614 LEPGE-----VVTGPCDN----------CTCVAGI-----LQCQEVPDCPDPGVWS 3649
Score = 30.4 bits (67), Expect = 7.5
Identities = 23/81 (28%), Positives = 30/81 (37%), Gaps = 3/81 (3%)
Query: 264 CKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGK 323
C D D V C CRP C G + R C I C G N +
Sbjct: 4686 CADLWDRVQCLQGPCRPG-CRCPPGQLVQDGR-CVPISSCRCGLPSANASWELAPAQAVQ 4743
Query: 324 FKCRSGECIDISKVCNQEQDC 344
C++ C++ S VC Q+C
Sbjct: 4744 LDCQNCTCVNESLVC-PHQEC 4763
Score = 30.0 bits (66), Expect = 9.8
Identities = 59/270 (21%), Positives = 86/270 (31%), Gaps = 45/270 (16%)
Query: 79 CNNGQCVPSRWKCDGDPDCEDGSDESP----EQC--------HMRTCRIHEISCGAHSTQ 126
C+N CV +C PDC D S E C +R+ R C + Q
Sbjct: 3624 CDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVSCGGGEQLRSRRCARPPCPGPARQ 3683
Query: 127 CIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDEL 186
S + E C +G C P E S +++ C S+G +E
Sbjct: 3684 SRTCSTQVCREAGCPAGRLYRE-----CQPGEGCPFSCAHVTQQVGC-----FSEGCEEG 3733
Query: 187 DCAPPTCGAHEFQC-STSSCIPISWVCDDDADCSDQSDESL---EQCGRQPVIHTKCPAS 242
P H C C+ +W+ + + L ++ + T
Sbjct: 3734 CHCPEGTFQHRLACVQECPCVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRT----- 3788
Query: 243 EIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRD 302
CG+ C H K C D DC + +D P P C SRQC
Sbjct: 3789 --SCGNCSCAHGKLSCSLD-DCFE-ADGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMP 3844
Query: 303 CVDGSDEVNCKNVNQCLGPGK-FKCRSGEC 331
+ G C GP + +C S +C
Sbjct: 3845 TLSGQG---------CRGPRQDLECPSPDC 3865
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 177 bits (450), Expect = 3e-44
Identities = 145/510 (28%), Positives = 215/510 (42%), Gaps = 108/510 (21%)
Query: 15 LCWAPRESGATGTGRKAKCEPSQ-FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCA 73
+C++P++ G++ C + F C +G CI +C+G DC D SDE +C C+
Sbjct: 255 ICFSPQQEN----GKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCS 307
Query: 74 ESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWR 133
E+ F C+ G+C+ CDG DC D SDE C+ T E CG +CI + W
Sbjct: 308 ENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTT----EHRCG--DGRCIAMEWV 361
Query: 134 CDGENDCDSGEDEENCGNITC-SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA--P 190
CDG++DC DE NC +C S C +G+CI F C+G +DC DGSDE +C+
Sbjct: 362 CDGDHDCVDKSDEVNC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQ 418
Query: 191 PTCGAHEFQCSTSSCIPI---SWVCDDD---ADCSDQSDESLEQCGRQP----------- 233
+C + +C + C+ S +CD + +CS +LE C P
Sbjct: 419 TSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFG 478
Query: 234 ------------------VIHTKC-------------PASEIQCGS------GECIHKKW 256
++ T C P ++ G C H K
Sbjct: 479 HRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKE 538
Query: 257 RCDG-----------DPDC----KDGSDEVNCPS-----RTCRPDQFECEDGSCIHGSRQ 296
RC+ D DC ++ SD C C P F+C G C+ SR+
Sbjct: 539 RCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRR 598
Query: 297 CNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG-ECIDISKVCNQEQDCRDWSDEP-LKE 354
C+G DC D SDE NC C ++C S +C+ + +C+ DC D+ DE
Sbjct: 599 CDGQADCDDDSDEENC----GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF 654
Query: 355 CHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLK 414
C +E N C + +DL E DC+ + D T N S + ++
Sbjct: 655 CQDDELECANHAC--VSRDLWCDGEADCSDSSDEWDCVTLS-----INVNSSSFLMVHRA 707
Query: 415 GGYKCECSRGYQMDLATGVCKAVG-KEPSL 443
C+ G+Q L+ CK +G EPS+
Sbjct: 708 ATEHHVCADGWQEILSQLACKQMGLGEPSV 737
Score = 108 bits (269), Expect = 3e-23
Identities = 105/434 (24%), Positives = 159/434 (36%), Gaps = 119/434 (27%)
Query: 39 QCTNGRCITLLWKCDGDEDCVDGSD--------------EKNCVKKTCAESDFVCNNGQC 84
+C NG+CI ++CDGDEDC DGSD ++ C+ C +S C
Sbjct: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSL 442
Query: 85 VPSRWKCDGDPDCED-----------GSDESPEQCHMRT--------------------- 112
+ CE S P RT
Sbjct: 443 CDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNC 502
Query: 113 --------CRIHEISCGAHSTQCIPV--------SWRCDG-----------ENDCDSGED 145
C I C ++ + IP RC+ + DC S
Sbjct: 503 YKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDC-SQFP 561
Query: 146 EENCGNITC----------SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGA 195
EEN N TC SP F C SG+C+ + C+GQ DC D SDE +C C
Sbjct: 562 EENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCG---CKE 618
Query: 196 HE-FQC-STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIH 253
+ ++C S C+ + +CD DC D DE + C + C E++C + C+
Sbjct: 619 RDLWECPSNKQCLKHTVICDGFPDCPDYMDE--KNC-------SFCQDDELECANHACVS 669
Query: 254 KKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
+ CDG+ DC D SDE +C + + S + R C DG E+ +
Sbjct: 670 RDLWCDGEADCSDSSDEWDCVTLS-----INVNSSSFLMVHRAATEHHVCADGWQEILSQ 724
Query: 314 NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDW-----SDEPLKECHINECLVNNGGCS 368
+ +G G+ ++K+ +++ W + E L ++E LVN C
Sbjct: 725 LACKQMGLGE--------PSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCE 776
Query: 369 HICKDLVIGYECDC 382
K ++ + DC
Sbjct: 777 SRSKISLLCTKQDC 790
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 145 bits (366), Expect = 2e-34
Identities = 70/162 (43%), Positives = 94/162 (58%), Gaps = 18/162 (11%)
Query: 156 PDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGA-HEFQCSTSSCIPISWVCDD 214
P +FTC +GRCI + C+G DC+D SDEL+C+ C A H+F C C P+ WVCD
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS---CDAGHQFTCKNKFCKPLFWVCDS 510
Query: 215 DADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP 274
DC D SDE + C CPA +C +G+C+ K +C+G DC DGSDE +CP
Sbjct: 511 VNDCGDNSDE--QGCS--------CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP 560
Query: 275 S---RTCRPDQFECEDGSCI-HGSRQCNGIRDCVDGSDEVNC 312
TC + C +G C+ G+ +C+G DC DGSDE +C
Sbjct: 561 KVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 131 bits (329), Expect = 3e-30
Identities = 70/169 (41%), Positives = 90/169 (53%), Gaps = 18/169 (10%)
Query: 35 PSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTC-AESDFVCNNGQCVPSRWKCDG 93
P QF C GRCI +CDG DC D SDE NC +C A F C N C P W CD
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCKNKFCKPLFWVCDS 510
Query: 94 DPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGN-- 151
DC D SDE C +T R + +C+ S +C+G++DC G DE +C
Sbjct: 511 VNDCGDNSDEQGCSCPAQTFR-------CSNGKCLSKSQQCNGKDDCGDGSDEASCPKVN 563
Query: 152 -ITCSPDEFTCSSGRCISR-NFVCNGQDDCSDGSDELDCAPPTCGAHEF 198
+TC+ + C +G C+S+ N C+G++DCSDGSDE DC CG F
Sbjct: 564 VVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC---DCGLRSF 609
Score = 123 bits (308), Expect = 8e-28
Identities = 62/158 (39%), Positives = 81/158 (51%), Gaps = 13/158 (8%)
Query: 77 FVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDG 136
F C G+C+ +CDG DC D SDE C H+ +C + C P+ W CD
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAG----HQFTC--KNKFCKPLFWVCDS 510
Query: 137 ENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAP---PTC 193
NDC DE+ C +C F CS+G+C+S++ CNG+DDC DGSDE C TC
Sbjct: 511 VNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC 567
Query: 194 GAHEFQCSTSSCIPI-SWVCDDDADCSDQSDESLEQCG 230
H ++C C+ + CD DCSD SDE CG
Sbjct: 568 TKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCG 605
Score = 103 bits (258), Expect = 5e-22
Identities = 63/172 (36%), Positives = 83/172 (48%), Gaps = 20/172 (11%)
Query: 187 DCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPAS-EIQ 245
D + P G +F C T CI CD ADC+D SDE ++ C A +
Sbjct: 448 DSSDPCPG--QFTCRTGRCIRKELRCDGWADCTDHSDE----------LNCSCDAGHQFT 495
Query: 246 CGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVD 305
C + C W CD DC D SDE C +C F C +G C+ S+QCNG DC D
Sbjct: 496 CKNKFCKPLFWVCDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGD 552
Query: 306 GSDEVNCKNVNQCL-GPGKFKCRSGECIDISKV-CNQEQDCRDWSDEPLKEC 355
GSDE +C VN ++C +G C+ C+ ++DC D SDE K+C
Sbjct: 553 GSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE--KDC 602
Score = 80.5 bits (197), Expect = 6e-15
Identities = 38/105 (36%), Positives = 57/105 (54%), Gaps = 4/105 (3%)
Query: 12 LLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVK-- 69
L +C + + G + C F+C+NG+C++ +C+G +DC DGSDE +C K
Sbjct: 504 LFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVN 563
Query: 70 -KTCAESDFVCNNGQCV-PSRWKCDGDPDCEDGSDESPEQCHMRT 112
TC + + C NG C+ +CDG DC DGSDE C +R+
Sbjct: 564 VVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRS 608
Score = 66.2 bits (160), Expect = 1e-10
Identities = 49/158 (31%), Positives = 66/158 (41%), Gaps = 28/158 (17%)
Query: 280 PDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCN 339
P QF C G CI +C+G DC D SDE+NC C +F C++ C + VC+
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS----CDAGHQFTCKNKFCKPLFWVCD 509
Query: 340 QEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDID- 398
DC D SDE C +NG C + K + DC G D +C ++
Sbjct: 510 SVNDCGDNSDEQGCSCPAQTFRCSNGKC--LSKSQQCNGKDDCGDG---SDEASCPKVNV 564
Query: 399 --------ECQNPGICSQICINLKGGYKC----ECSRG 424
C N G+C KG +C +CS G
Sbjct: 565 VTCTKHTYRCLN-GLCLS-----KGNPECDGKEDCSDG 596
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 137 bits (345), Expect = 4e-32
Identities = 87/268 (32%), Positives = 136/268 (50%), Gaps = 15/268 (5%)
Query: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI-DNVYNPAAIAVDWVYKTIYWT 530
+ L D + ++W D+++ +I AS+ G +I ++ +P IAVD + + I+WT
Sbjct: 981 IGLAFDCVDKMVYWTDITEPSIGRASLHG--GEPTTIIRQDLGSPEGIAVDHLGRNIFWT 1038
Query: 531 DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG-EPAKIEKAGMNGF 589
D+ I VA LDGT+R+ LF +DL P I D + G +YW+DW + KIE + M+G
Sbjct: 1039 DSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1098
Query: 590 DRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLA 649
+RR LV D+ PNG+T D S+L W+D+ + ++ + RR K+LE L +P A
Sbjct: 1099 NRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRR---KALEGLQYPFA 1155
Query: 650 LTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709
+T + +Y+ D + +V + E + I P G N+C
Sbjct: 1156 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC--S 1213
Query: 710 MENGGCEYLCLPAPQINDHSPKYTCSCP 737
+ NGGC +LCL P TC CP
Sbjct: 1214 VNNGGCTHLCLATP------GSRTCRCP 1235
Score = 58.2 bits (139), Expect = 3e-08
Identities = 53/169 (31%), Positives = 66/169 (39%), Gaps = 36/169 (21%)
Query: 278 CRPD---QFECEDGSCIHGS-RQCNGIRDC-----VDGSDEVNCKNVNQCLGPGKFKCRS 328
CRP QF CE G R C I +C V GS + C N PG F+C
Sbjct: 685 CRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTI-CNN-----HPGTFRCEC 738
Query: 329 GECIDISK----VCNQEQDCRDWSDEPLKECHINE---CLVNNGGCSHICKDLVIGYECD 381
E S V +Q ++ + L C I + C+ G Y C
Sbjct: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS----------SYTCS 788
Query: 382 CAAGFELIDRKTCGDIDECQNPGIC--SQICINLKGGYKCECSRGYQMD 428
C GF D + C D+DECQ P C C N G + C+C GYQ D
Sbjct: 789 CLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835
Score = 55.5 bits (132), Expect = 2e-07
Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 5/121 (4%)
Query: 545 TKRKFLFNSDLREPASI----AVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
T RK + L PA + A D + VYW+D EP+ I +A ++G + ++ D+
Sbjct: 963 TMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS-IGRASLHGGEPTTIIRQDLG 1021
Query: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
P GI +D + ++W DS L + L+G RR++ ++ + +YW
Sbjct: 1022 SPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWT 1081
Query: 661 D 661
D
Sbjct: 1082 D 1082
Score = 54.7 bits (130), Expect = 4e-07
Identities = 33/86 (38%), Positives = 44/86 (51%), Gaps = 8/86 (9%)
Query: 358 NECLVNNGGC--SHICKDLV-IGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQ--ICI 411
N C + GC + C+ + C+C+ GF D +TC DIDEC + P +C IC
Sbjct: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICN 728
Query: 412 NLKGGYKCECSRGYQMDLATGVCKAV 437
N G ++CEC GYQ G C AV
Sbjct: 729 NHPGTFRCECVEGYQFS-DEGTCVAV 753
Score = 32.7 bits (73), Expect = 1.5
Identities = 15/38 (39%), Positives = 20/38 (52%), Gaps = 3/38 (7%)
Query: 358 NECLVNNGGCSHICKDLVIGYECDC---AAGFELIDRK 392
N C VNNGGC+H+C C C G + I++K
Sbjct: 1210 NYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 133 bits (334), Expect = 8e-31
Identities = 68/205 (33%), Positives = 111/205 (54%), Gaps = 4/205 (1%)
Query: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
V +D D + ++W D++ + I A ++ + + +P +A+D + +T+YWTD
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
Query: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG-EPAKIEKAGMNGFD 590
+ I A LDG++RK LF +DL P +IAVDP+ G +YW+DW E KIE + ++G +
Sbjct: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264
Query: 591 RRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLAL 650
RR L+ DI PNG+T D L W D+ L +G RR++ +L++ P ++
Sbjct: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKY---PFSI 1321
Query: 651 TIFEDRVYWIDGENEAVYGANKFTG 675
+ D Y D + V NK +G
Sbjct: 1322 VSYADHFYHTDWRRDGVVSVNKHSG 1346
Score = 48.5 bits (114), Expect = 3e-05
Identities = 55/192 (28%), Positives = 74/192 (38%), Gaps = 42/192 (21%)
Query: 259 DGDPD----CKDGSDEVNCPSRTCRPD---QFECEDGSCIHGS-RQCNGIRDCVDGSDEV 310
D DP C DGS + +R C P + CE S G R C +C G
Sbjct: 754 DSDPTPGNPCYDGSHMCDTTAR-CHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRC 812
Query: 311 NCKNVNQCLG-PGKFKC--RSG--------ECIDISKVCNQEQDCRDWSDE--PLKECHI 357
+V C+ PG ++C RSG CI I+ N C D S P +
Sbjct: 813 GPNSV--CINLPGSYRCECRSGYEFADDRHTCILITPPANP---CEDGSHTCAPAGQARC 867
Query: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQICINLKGG 416
V++GG + + C C G+ D C D+DEC +N + C N G
Sbjct: 868 ----VHHGGST---------FSCACLPGYAG-DGHQCTDVDECSENRCHPAATCYNTPGS 913
Query: 417 YKCECSRGYQMD 428
+ C C GY D
Sbjct: 914 FSCRCQPGYYGD 925
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 126 bits (316), Expect = 1e-28
Identities = 63/190 (33%), Positives = 106/190 (55%), Gaps = 3/190 (1%)
Query: 483 LFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATL 542
++W D AI A +D G + + +P IAV+WV +++YWT ++ I V L
Sbjct: 5 VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
Query: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602
+ T K L + D+ EP +IA+ P G YW DWGE +I++A ++ + R LV A + WP
Sbjct: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
Query: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662
NG+ LDL + +LYW D+K + ++ ++ R+ +LK + L H T+ D +YW
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWTAW 181
Query: 663 ENEAVYGANK 672
++ ++ +K
Sbjct: 182 QHHSIKRVHK 191
>gi|209447022 low density lipoprotein receptor-related protein
5-like [Homo sapiens]
Length = 252
Score = 126 bits (316), Expect = 1e-28
Identities = 63/190 (33%), Positives = 106/190 (55%), Gaps = 3/190 (1%)
Query: 483 LFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATL 542
++W D AI A +D G + + +P IAV+WV +++YWT ++ I V L
Sbjct: 5 VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
Query: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602
+ T K L + D+ EP +IA+ P G YW DWGE +I++A ++ + R LV A + WP
Sbjct: 64 NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123
Query: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662
NG+ LDL + +LYW D+K + ++ ++ R+ +LK + L H T+ D +YW
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWTAW 181
Query: 663 ENEAVYGANK 672
++ ++ +K
Sbjct: 182 QHHSIKRVHK 191
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 122 bits (307), Expect = 1e-27
Identities = 71/211 (33%), Positives = 87/211 (41%), Gaps = 58/211 (27%)
Query: 154 CSPDEFTCSS-GRCISRNFVCNGQDDCSDGSDELDCAPPT-------------------- 192
C+ EF C S C++ + C+ + DC D SDEL+C P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 193 --------------------------CGAHEFQCSTSSCIPISWVCDDDADCSDQSDESL 226
CG E C CIP ++CD DC D SDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL- 317
Query: 227 EQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSR----TCRPDQ 282
CG P C +E CG+G C K WRCDGD DC+D +DE NCP++ C P Q
Sbjct: 318 -DCGPPP----PCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQ 372
Query: 283 FEC-EDGSCIHGSRQCNGIRDCVDGSDEVNC 312
F C CI S C+ DC D SDE C
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 121 bits (303), Expect = 3e-27
Identities = 73/232 (31%), Positives = 104/232 (44%), Gaps = 53/232 (22%)
Query: 70 KTCAESDFVCNN-GQCVPSRWKCDGDPDCEDGSDE------------------------- 103
+ C E++F C++ +CV ++CD PDC D SDE
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256
Query: 104 SPEQCHMRTC------------RIHEISCGAHST-----QCIPVSWRCDGENDCDSGEDE 146
PE MR + + CG CIP + CDG+ DC+ G DE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316
Query: 147 ENCG-NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC----APPTCGAHEFQC- 200
+CG C P+EF C +G C + + C+G DC D +DE +C CG +F+C
Sbjct: 317 LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCV 376
Query: 201 STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECI 252
ST+ CIP S+ CD+++DC D+SDE G P P IQ G+ +
Sbjct: 377 STNMCIPASFHCDEESDCPDRSDE----FGCMPPQVVTPPRESIQASRGQTV 424
Score = 119 bits (298), Expect = 1e-26
Identities = 65/211 (30%), Positives = 91/211 (43%), Gaps = 52/211 (24%)
Query: 111 RTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGN------------------- 151
R C E +C +++ +C+ + +RCD DC DE NC
Sbjct: 197 RACTEAEFACHSYN-ECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255
Query: 152 ---------------------------ITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSD 184
+ C P E C +G CI R+++C+GQ+DC DGSD
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315
Query: 185 ELDCA-PPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASE 243
ELDC PP C +EF C C W CD D DC D++DE+ R + C ++
Sbjct: 316 ELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEV---CGPTQ 372
Query: 244 IQC-GSGECIHKKWRCDGDPDCKDGSDEVNC 273
+C + CI + CD + DC D SDE C
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 112 bits (279), Expect = 2e-24
Identities = 66/211 (31%), Positives = 86/211 (40%), Gaps = 55/211 (26%)
Query: 33 CEPSQFQCTN-GRCITLLWKCDGDEDCVDGSDEKNCVKKT-------------------- 71
C ++F C + C+ L ++CD DC D SDE NC +
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258
Query: 72 --------------------------CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESP 105
C + C NG C+P + CDG DCEDGSDE
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL- 317
Query: 106 EQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC----GNITCSPDEFTC 161
+ C +E CG + C WRCDG+ DC+ DE NC C P +F C
Sbjct: 318 DCGPPPPCEPNEFPCG--NGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC 375
Query: 162 -SSGRCISRNFVCNGQDDCSDGSDELDCAPP 191
S+ CI +F C+ + DC D SDE C PP
Sbjct: 376 VSTNMCIPASFHCDEESDCPDRSDEFGCMPP 406
Score = 110 bits (274), Expect = 7e-24
Identities = 53/127 (41%), Positives = 67/127 (52%), Gaps = 4/127 (3%)
Query: 26 GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC-VKKTCAESDFVCNNGQC 84
G+ R C P + C NG CI + CDG EDC DGSDE +C C ++F C NG C
Sbjct: 278 GSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHC 337
Query: 85 VPSRWKCDGDPDCEDGSDES--PEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDS 142
W+CDGD DCED +DE+ P + C + C + CIP S+ CD E+DC
Sbjct: 338 ALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC-VSTNMCIPASFHCDEESDCPD 396
Query: 143 GEDEENC 149
DE C
Sbjct: 397 RSDEFGC 403
Score = 77.0 bits (188), Expect = 7e-14
Identities = 50/168 (29%), Positives = 66/168 (39%), Gaps = 48/168 (28%)
Query: 230 GRQPVIHTKCPASEIQCGS-GECIHKKWRCDGDPDCKDGSDEVNC--------------- 273
G P C +E C S EC+ ++RCD PDC+D SDE+NC
Sbjct: 190 GTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLV 249
Query: 274 --------PSRT-----------------------CRPDQFECEDGSCIHGSRQCNGIRD 302
P T C P + C +G CI C+G D
Sbjct: 250 ETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQED 309
Query: 303 CVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
C DGSDE++C C P +F C +G C C+ + DC D +DE
Sbjct: 310 CEDGSDELDCGPPPPC-EPNEFPCGNGHCALKLWRCDGDFDCEDRTDE 356
Score = 34.3 bits (77), Expect = 0.52
Identities = 43/181 (23%), Positives = 58/181 (32%), Gaps = 38/181 (20%)
Query: 83 QC-VPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
QC P ++ DC+ G +P ++ TC SC HS C P + C G C
Sbjct: 1125 QCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCE--RCSCHGHSEACEPETGACQG---CQ 1179
Query: 142 SGEDEENCGNITCSPDEF---------TCSSGRCISRNFVCNGQDDC---SDGSDELD-C 188
+ C C P + C C C +DG D C
Sbjct: 1180 HHTEGPRCEQ--CQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDAC 1237
Query: 189 APPTCGAHEFQCST---------SSCI-------PISWVCDDDADCSDQSDESLE-QCGR 231
+P G H +C+ C PI CD S Q D + + QC
Sbjct: 1238 SPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKA 1297
Query: 232 Q 232
Q
Sbjct: 1298 Q 1298
>gi|24430141 fibrillin 1 precursor [Homo sapiens]
Length = 2871
Score = 118 bits (296), Expect = 2e-26
Identities = 130/483 (26%), Positives = 183/483 (37%), Gaps = 98/483 (20%)
Query: 32 KCEPSQFQCTNGRCITLL--WKCDGDEDCVDGSDEKNCVK-KTCAESDFVCNNGQCV--P 86
+C+ CT+G+C + +KC D S+E+NC C S +C GQCV P
Sbjct: 1031 ECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTP 1090
Query: 87 SRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146
++C D E G + C+ + C S+RC+ +
Sbjct: 1091 GDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNI 1150
Query: 147 ENCGNIT-CSPDEFTCSSGRCISRNFVCNGQDDCSDG----SDELDCAP-PTC----GAH 196
C +I C C +GRC+ N + Q C+ G D L C C G
Sbjct: 1151 SACIDINECELSAHLCPNGRCV--NLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGC 1208
Query: 197 EFQCSTS------SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGE 250
E C+ S SC P + D C+D +++C P I C G+
Sbjct: 1209 ETFCTNSEGSYECSCQPGFALMPDQRSCTD-----IDECEDNPNI----------CDGGQ 1253
Query: 251 C--IHKKWRC---DGDPDCKDGSDEVN----------CPSRTCRPDQ----FECEDG-SC 290
C I ++RC DG +D V+ C S TC + C+ G S
Sbjct: 1254 CTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSG 1313
Query: 291 IHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP-GKFKCRSG--------------ECIDIS 335
G C I +C G+ NC C G FKC EC + +
Sbjct: 1314 KKGKTGCTDINECEIGAH--NCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGT 1371
Query: 336 KVCNQEQDCRD-----------------WSDEPLKECHINECLVNNGGCSHICKDLVIGY 378
+C+Q DC++ ++ L EC N L NG C + GY
Sbjct: 1372 HMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPG----GY 1427
Query: 379 ECDCAAGF-ELIDRKTCGDIDECQNPGICS-QICINLKGGYKCECSRGYQMDLATGVCKA 436
C+C GF D K C DIDEC P IC C NL G ++CEC GY++D + G C
Sbjct: 1428 RCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTD 1487
Query: 437 VGK 439
V +
Sbjct: 1488 VNE 1490
Score = 93.6 bits (231), Expect = 7e-19
Identities = 106/405 (26%), Positives = 163/405 (40%), Gaps = 84/405 (20%)
Query: 78 VCNNGQCVPSR--WKCDGDPDCEDGS--DESPEQC---HMRTC--RIHEISCGAHSTQCI 128
VC NG CV +R +KC C G D + C + TC R + C +
Sbjct: 920 VCKNGLCVNTRGSFKCQ----CPSGMTLDATGRICLDIRLETCFLRYEDEEC------TL 969
Query: 129 PVSWRCDGENDCDS------GEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDG 182
P++ R + C S E+ E C E C G + + NG+ D
Sbjct: 970 PIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKD- 1028
Query: 183 SDELDCAPPTCGAHE-------FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235
+E P C + F+C S + ++ +C+D +++C P +
Sbjct: 1029 INECKMIPSLCTHGKCRNTIGSFKCRCDSGFALD---SEERNCTD-----IDECRISPDL 1080
Query: 236 HTKCPASEIQCGSGECIHKKWRCDGDPDCK--DGSDE-----VNCPS-RTCRPDQFECED 287
CG G+C++ GD +CK +G + NC C+ D C
Sbjct: 1081 ----------CGRGQCVNTP----GDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRG 1126
Query: 288 GSC--IHGSRQCNGIRDCVDG---SDEVN-CKNVNQCLGPGKFKCRSGECIDI----SKV 337
G C GS +C +C G S ++ C ++N+C C +G C+++
Sbjct: 1127 GVCHNTEGSYRC----ECPPGHQLSPNISACIDINECELSAHL-CPNGRCVNLIGKYQCA 1181
Query: 338 CNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGD 396
CN + + L I+EC + NGGC C + YEC C GF L+ D+++C D
Sbjct: 1182 CNPGYHS---TPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD 1238
Query: 397 IDECQ-NPGIC-SQICINLKGGYKCECSRGYQMDLATGVCKAVGK 439
IDEC+ NP IC C N+ G Y+C C G+ C V +
Sbjct: 1239 IDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNE 1283
Score = 93.6 bits (231), Expect = 7e-19
Identities = 113/451 (25%), Positives = 168/451 (37%), Gaps = 62/451 (13%)
Query: 32 KCEPSQFQCTNGRCITLL--WKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS-- 87
+C+ N CI ++CD S + + C E +C++GQC+ +
Sbjct: 1811 ECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVG 1870
Query: 88 RWKC---------DGDPDCEDGSDESPEQCHMRTCR--IHEISCG-------AHSTQCIP 129
+ C D C D ++ + C TCR I +C +H+ CI
Sbjct: 1871 SFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCID 1930
Query: 130 VSWRCDGE-NDCDSGEDEENCGNITC--------SPDEFTCSS-GRCISRNFVCN-GQDD 178
V G N C +G+ G+ C +PD TC C+ C G
Sbjct: 1931 VDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQ 1990
Query: 179 CSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVC--------DDDADCSDQSDESLEQCG 230
DGS C P +E C+ +C + C SL G
Sbjct: 1991 NLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSG 2050
Query: 231 R--QPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDG--SDEVNCPSRTCRPDQFECE 286
R Q + + C A + G+C K R +C + P C + E
Sbjct: 2051 RRCQDLRMSYCYA---KFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAF 2107
Query: 287 DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRD 346
C +GS G D DE CK + C + G+CI+ + +C
Sbjct: 2108 RQICPYGSGIIVGPDDSAVDMDE--CKEPDVC--------KHGQCINTDG--SYRCECPF 2155
Query: 347 WSDEPLKEC-HINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDEC-QNPG 404
EC +EC V N + CK+++ G+EC C GFE TC DI+EC QNP
Sbjct: 2156 GYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPL 2215
Query: 405 ICSQICINLKGGYKCECSRGYQMDLATGVCK 435
+C+ C+N G Y+C+C GY + +CK
Sbjct: 2216 LCAFRCVNTYGSYECKCPVGYVLREDRRMCK 2246
Score = 88.6 bits (218), Expect = 2e-17
Identities = 124/514 (24%), Positives = 187/514 (36%), Gaps = 122/514 (23%)
Query: 30 KAKCEPSQF----QCTN-GRCITLLWKCDGDEDCVDGSDEKNCVKKT------------- 71
K C P +CT+ C C DC + C+ K
Sbjct: 1347 KCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLD 1406
Query: 72 -CAESDFVCNNGQCV--PSRWKCDGD----PDCEDGSDESPEQCHMRTCRIHEISCGAHS 124
C+E+ +C NGQC+ P ++C+ D P + + E ++C + C +
Sbjct: 1407 ECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNI------CVFGT 1460
Query: 125 TQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISR--NFVCN-------- 174
+P +RC+ E + NC ++ D TC SG C++ +++C+
Sbjct: 1461 CHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELN 1520
Query: 175 ----GQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCG 230
G D G+ LD P + CS + +S + C C
Sbjct: 1521 PTRVGCVDTRSGNCYLDIRPRGDNG-DTACSNEIGVGVSKA----SCCCSLGKAWGTPCE 1575
Query: 231 RQPVIHTK-----CPASE---------IQCGSGECIHKKWRCDGDPDCKD-GSDEVNCPS 275
P ++T CP E I EC C G GS + CP+
Sbjct: 1576 MCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPT 1635
Query: 276 --------RTCRPDQFECED------GSCIH--GSRQC---------NGIRDCVDGSDEV 310
R C D ECE G+C + G+ C NG +C+D +
Sbjct: 1636 GYYLNEDTRVC-DDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSL 1694
Query: 311 NCKNV---NQ-CLGPGKFKCRSGECI---DISKVCNQ--EQDCRDWSDEPLKEC------ 355
+N NQ C G F C +I + N+ EQ +DE C
Sbjct: 1695 CYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPG 1754
Query: 356 -----------HINECLVNNGGCSH-ICKDLVIGYECDCAAGFELIDRK-TCGDIDECQN 402
I+EC G C + +C ++V + C+C GF D+ C DIDECQN
Sbjct: 1755 FVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQN 1814
Query: 403 PGICSQ--ICINLKGGYKCECSRGYQMDLATGVC 434
+C + CIN G Y+C+C GY+ +TG C
Sbjct: 1815 GPVCQRNAECINTAGSYRCDCKPGYRF-TSTGQC 1847
Score = 87.8 bits (216), Expect = 4e-17
Identities = 113/428 (26%), Positives = 159/428 (37%), Gaps = 92/428 (21%)
Query: 40 CTNGRCITLLWKCDGDEDCVD------GSDEKNCVKKTCAESDFVCNNGQCVPS--RWKC 91
C NG CI DG C+ SD + C E+ +C NG+CV + ++C
Sbjct: 582 CLNGMCINE----DGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRC 637
Query: 92 DGDPDCEDGSDESP-EQCHMRTCRIHEISC--GAHSTQCIPVSWRCDGENDCDSGEDEEN 148
+ P G D HMR+ +C G QCI + +++C E
Sbjct: 638 ECFPGLAVGLDGRVCVDTHMRS------TCYGGYKRGQCIKPLFGAVTKSECCCASTEYA 691
Query: 149 CGNITCSPDEFTCSSGRCISRNFVCN-GQDDCSDGSDELDCA--PPTC--GAHEFQCSTS 203
G C P C + +C+ G S GSD +CA P C G E T
Sbjct: 692 FGE-PCQP----CPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTY 746
Query: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
CI C+ S ++ G+ V +C + + C +G+C +
Sbjct: 747 KCI-----------CN--SGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTP-------- 785
Query: 264 CKDGSDEVNCPSRTC-RPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPG 322
GS CP +PD CED S NG+ CKN PG
Sbjct: 786 ---GSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGV-----------CKN-----SPG 826
Query: 323 KF--KCRSGECIDISK-VCNQEQDCRDWSDEPLKECHINECLVNNGGC--SHICKDL--V 375
F +C S +D +K +C + W C IN NG S C L
Sbjct: 827 SFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEINI----NGATLKSQCCSSLGAA 882
Query: 376 IGYECD-------CAAGFELIDRKTCGDIDECQ-NPGICSQ-ICINLKGGYKCECSRGYQ 426
G C C G+ I C DIDEC+ PG+C +C+N +G +KC+C G
Sbjct: 883 WGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMT 942
Query: 427 MDLATGVC 434
+D +C
Sbjct: 943 LDATGRIC 950
Score = 84.7 bits (208), Expect = 3e-16
Identities = 108/460 (23%), Positives = 171/460 (37%), Gaps = 90/460 (19%)
Query: 40 CTNGRCITL--LWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQC--VPSRWKCDGDP 95
C +G+CI ++C+ + +E CV C NG C V ++C
Sbjct: 2137 CKHGQCINTDGSYRCECPFGYILAGNE--CVDTDECSVGNPCGNGTCKNVIGGFECT--- 2191
Query: 96 DCEDGSDESPEQC--HMRTCRIHEISC--------GAHSTQCIPVSW-------RCDGEN 138
CE+G + P + C + + C G++ +C PV + C E+
Sbjct: 2192 -CEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKC-PVGYVLREDRRMCKDED 2249
Query: 139 DCDSG-----EDEENCGNIT------CSPDEFTCSSGR-CISRNFVCNGQDDCSDGSDEL 186
+C+ G E + C N+ C P G C+ N C +G
Sbjct: 2250 ECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGR--- 2306
Query: 187 DCAPPTCGAHEFQCSTS-SCIPISWVCDDDAD--CSDQSDESLEQCG---RQPVIHTKC- 239
T G++ +C+ + P C D+ + C + +++ Q G R PV ++C
Sbjct: 2307 --CLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECC 2364
Query: 240 --------PASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCI 291
P EI G KK G +G+D C+ C +G C+
Sbjct: 2365 CDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGAD-----IDECKVIHDVCRNGECV 2419
Query: 292 H--GSRQC---NGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGEC---IDISKVCNQEQD 343
+ GS C G + G+ V+ NQ P F C++ E K ++D
Sbjct: 2420 NDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQED 2479
Query: 344 CRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGF-----ELIDRKTC-GDI 397
R D ++EC C +C + + G+ C C GF ID C DI
Sbjct: 2480 GRSCKD-------LDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDI 2532
Query: 398 DECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
+ C + GIC N G + CEC RG+ +D C+ V
Sbjct: 2533 NLCGSKGICQ----NTPGSFTCECQRGFSLDQTGSSCEDV 2568
Score = 82.0 bits (201), Expect = 2e-15
Identities = 118/524 (22%), Positives = 190/524 (36%), Gaps = 146/524 (27%)
Query: 32 KCEPSQFQCTNGRCITLLWK-----------------CDGDEDC--VDGSDEKNCVKKTC 72
+CE S C NGRC+ L+ K C ++C ++G E C T
Sbjct: 1158 ECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFC---TN 1214
Query: 73 AESDFVCN---NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIP 129
+E + C+ +P + C +CED +P C C IP
Sbjct: 1215 SEGSYECSCQPGFALMPDQRSCTDIDECED----NPNICDGGQCTN------------IP 1258
Query: 130 VSWRCDGENDCDSGEDEENCGNIT-CSPDEFTCSSGRCISR--NFVCN---------GQD 177
+RC + + ED + C ++ C + C SG C + +F+C+ G+
Sbjct: 1259 GEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKT 1318
Query: 178 DCSDGSDELDCAPPTCGAH--------EFQCSTS--------------SCIPISWVCDDD 215
C+D +E + CG H F+CS S C + +C
Sbjct: 1319 GCTD-INECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQH 1377
Query: 216 ADCSDQSDESLEQC-------GRQPVIHTKCPASEIQCGSGECIHKK--WRCDGDPDCKD 266
ADC + C G +C + CG+G+C++ +RC+ D
Sbjct: 1378 ADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVP 1437
Query: 267 GSDEVNCPSRTCRPDQFECE-DGSCIHGSRQCNGIRDCVDGSDEV---------NCKNVN 316
+D C D EC C+ G+ C+ + E+ NC +VN
Sbjct: 1438 SADGKACE------DIDECSLPNICVFGT--CHNLPGLFRCECEIGYELDRSGGNCTDVN 1489
Query: 317 QCLGPGKFKCRSGECIDI--SKVCNQEQDCR------DWSDEPLKECHINECLVNNGGCS 368
+CL P C SG C++ S +C+ D D C+++ + G +
Sbjct: 1490 ECLDPTT--CISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDT 1547
Query: 369 HICKDLVIGYE---CDCAAG-----------------FELIDRKTCG-----------DI 397
++ +G C C+ G ++++ G DI
Sbjct: 1548 ACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDI 1607
Query: 398 DECQN-PGICSQ-ICINLKGGYKCECSRGYQMDLATGVCKAVGK 439
DECQ PG+C CIN G ++C C GY ++ T VC V +
Sbjct: 1608 DECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE 1651
Score = 78.2 bits (191), Expect = 3e-14
Identities = 103/431 (23%), Positives = 154/431 (35%), Gaps = 104/431 (24%)
Query: 52 CDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMR 111
C + G D+ C E D VC +GQC+ + DG CE
Sbjct: 2111 CPYGSGIIVGPDDSAVDMDECKEPD-VCKHGQCINT----DGSYRCE------------- 2152
Query: 112 TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNF 171
C I G +C+ C N C +G + G C TC G
Sbjct: 2153 -CPFGYILAG---NECVDTD-ECSVGNPCGNGTCKNVIGGFEC-----TCEEGFEPGPMM 2202
Query: 172 VCNGQDDCSDGSDELDCA---PPTCGAHEFQCSTSSCIPISWV-------CDDDADCSDQ 221
C ++C+ + L CA T G++E +C P+ +V C D+ +C +
Sbjct: 2203 TCEDINECAQ--NPLLCAFRCVNTYGSYECKC------PVGYVLREDRRMCKDEDECEEG 2254
Query: 222 SDESLEQ--------------CG----RQP-----VIHTKCPASEIQCGSGECIHKK--W 256
+ E+ CG R+P V +C C +G C++ + +
Sbjct: 2255 KHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSY 2314
Query: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECED---GSCIHGSRQCNGIRDCVDGSDEVNCK 313
C+ C DG T P+Q EC D G C Q C GS N
Sbjct: 2315 TCE----CNDGF--------TASPNQDECLDNREGYCFTEVLQ----NMCQIGSSNRNPV 2358
Query: 314 NVNQCL-------GPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGG 366
++C GP C + K+C + + + EC + + NG
Sbjct: 2359 TKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMT-NGADIDECKVIHDVCRNGE 2417
Query: 367 CSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRG 424
C + Y C C G+ I +C D++EC Q P C+ IC N +G Y+C C +G
Sbjct: 2418 CVNDRGS----YHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKG 2473
Query: 425 YQMDLATGVCK 435
Y + CK
Sbjct: 2474 YILQEDGRSCK 2484
Score = 78.2 bits (191), Expect = 3e-14
Identities = 112/452 (24%), Positives = 167/452 (36%), Gaps = 94/452 (20%)
Query: 32 KCEPSQFQCTNGR--CITLLWKCDGDEDCVDGS------DEKNCVKKT-CAESDFVCNNG 82
+CE + CT + C L+ G C+ G D + CV + C +C NG
Sbjct: 2250 ECEEGKHDCTEKQMECKNLI----GTYMCICGPGYQRRPDGEGCVDENECQTKPGICENG 2305
Query: 83 QCVPSR--WKCDGDPDCEDGSDESPEQCHMRTCR-------IHEISCGAHSTQCIPVSWR 133
+C+ +R + C+ C DG SP Q R + + C S+ PV+
Sbjct: 2306 RCLNTRGSYTCE----CNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVT-- 2359
Query: 134 CDGENDCDSGEDE----ENCGNITCSPDEFTCSSGRCISRNFVCNGQD--DCSDGSDELD 187
E CD G E C + C GR F+ NG D +C D
Sbjct: 2360 -KSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGR----GFMTNGADIDECKVIHDV-- 2412
Query: 188 CAPPTC----GAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQP-----VIHTK 238
C C G++ C T I+ C D L +C + P +
Sbjct: 2413 CRNGECVNDRGSYHCICKTGYTPDIT-----GTSCVD-----LNECNQAPKPCNFICKNT 2462
Query: 239 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP--------SRTCR-PDQFECEDGS 289
+ + C G + + R D D + + + NC TC+ P F S
Sbjct: 2463 EGSYQCSCPKGYILQEDGRSCKDLD-ECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTS 2521
Query: 290 CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSD 349
CI + + I C GS + C+N PG F C EC + C D
Sbjct: 2522 CIDNNECTSDINLC--GSKGI-CQNT-----PGSFTC---ECQRGFSLDQTGSSCED--- 2567
Query: 350 EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGF-ELIDRKTCGDIDECQNPGICSQ 408
++EC N C H C++++ GY C C G+ + C D +EC + IC
Sbjct: 2568 -------VDEC-EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGG 2619
Query: 409 I-CINLKGGYKCECSRGYQMDLATGVCKAVGK 439
C N G YKC C G+Q + +G C+ + +
Sbjct: 2620 ASCHNTLGSYKCMCPAGFQYEQFSGGCQDINE 2651
Score = 74.3 bits (181), Expect = 5e-13
Identities = 103/441 (23%), Positives = 158/441 (35%), Gaps = 87/441 (19%)
Query: 33 CEPSQFQCTNGRCITLLWKC----------DGDEDCVDGSDEKNCVKKTCAESDFVCNNG 82
C+ ++ C NGRCI C D +C+D + C K CA + + N G
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDE---CEKNPCAGGECINNQG 509
Query: 83 ----------QCVPSRWKCDGDPDC-EDGSDESPEQCHMRTCRIHEI-SCGAHSTQ---- 126
Q +R +C +C ++G + +C H + + G H T+
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKN 569
Query: 127 CIPVSWRCDGENDCDSGE--DEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSD 184
C + C N C +G +E+ C P S GR C C +G
Sbjct: 570 CEDMD-ECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGR- 627
Query: 185 ELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEI 244
T G++ +C + + D C D S G +
Sbjct: 628 ----CVNTDGSYRCECFPGLAVGL-----DGRVCVDTHMRSTCYGGYK------------ 666
Query: 245 QCGSGECIHKKWRCDGDPDCKDGSDEVN-------CPSRTCRPDQFECEDGSCIHGSRQC 297
G+CI + +C S E CP++ Q C G + +
Sbjct: 667 ---RGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAG-- 721
Query: 298 NGIRDCVDGSDEVN---CKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKE 354
+ I +C D C+N+ G K C SG +D + ++C D + E
Sbjct: 722 SDINECALDPDICPNGICENLR---GTYKCICNSGYEVD-----STGKNCVD-----INE 768
Query: 355 CHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINL 413
C +N L +NG C + V C C GF D KTC DIDEC++ + +C N
Sbjct: 769 CVLNSLLCDNGQCRNTPGSFV----CTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNS 824
Query: 414 KGGYKCECSRGYQMDLATGVC 434
G + CECS +D +C
Sbjct: 825 PGSFICECSSESTLDPTKTIC 845
Score = 71.2 bits (173), Expect = 4e-12
Identities = 64/197 (32%), Positives = 91/197 (46%), Gaps = 25/197 (12%)
Query: 278 CRPDQFECEDGSCIH--GSRQCNGIRDCVDGSD---EVNCKNVNQCLGPGKFKCRSGECI 332
C+ ++ C++G CI GS +C +C G C +V++C K C GECI
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRC----ECNKGFQLDLRGECIDVDEC---EKNPCAGGECI 505
Query: 333 DI--SKVCNQEQDCRDWSDEPLK--ECH-INECLVNNGGCSH-ICKDLVIGYECDCAAGF 386
+ S C CR L EC I+ECL N C++ C + + C C AGF
Sbjct: 506 NNQGSYTCQ----CRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGF 561
Query: 387 ELI-DRKTCGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVCKAVGK-EPSL 443
+ D K C D+DEC +C + +CIN G +KC C G+Q+ CK + + E
Sbjct: 562 HVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPG 621
Query: 444 IFTNRRDIRKIGLERKE 460
I N R + G R E
Sbjct: 622 ICMNGRCVNTDGSYRCE 638
Score = 50.1 bits (118), Expect = 9e-06
Identities = 54/219 (24%), Positives = 79/219 (36%), Gaps = 33/219 (15%)
Query: 240 PASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDG-SCIHGSRQCN 298
P CG G C C C G +C SR+ + C +G SC C
Sbjct: 83 PICRHSCGDGFCSRPNM-CT----CPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQ 137
Query: 299 GI---RDCVDGSDEVNCKNVNQCLGPGKFKC-------------RSGECIDISKVCNQEQ 342
C E C N +C+ P + C R+G C + Q
Sbjct: 138 KGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVIS----NQ 193
Query: 343 DCRDWSDEPLKECHINECLVNNGGC-SHICKDLVIGYECDCAAGF-ELIDRKTCGDIDEC 400
C+ + C C G H C ++ C GF I C D+DEC
Sbjct: 194 MCQGQLSGIV--CTKTLCCATVGRAWGHPC-EMCPAQPHPCRRGFIPNIRTGACQDVDEC 250
Query: 401 QN-PGICSQ-ICINLKGGYKCECSRGYQMDLATGVCKAV 437
Q PG+C CIN G ++C+C G++++ + C+ +
Sbjct: 251 QAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDI 289
Score = 40.4 bits (93), Expect = 0.007
Identities = 80/313 (25%), Positives = 104/313 (33%), Gaps = 61/313 (19%)
Query: 120 CGA-HSTQCIPVSWRCDGENDCDSGEDEENCGNITCS-PDEFTCSSGR----CISR---- 169
CG+ ++ C P G N C +CG+ CS P+ TC SG+ C SR
Sbjct: 59 CGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQH 118
Query: 170 -NFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQ 228
N C CSD D C G H Q S C C+ + Q
Sbjct: 119 CNIRCMNGGSCSD--DHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQ 176
Query: 229 CGRQ--------PVIHTKCPA--SEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRT- 277
C R + + C S I C C R G P C+ CP++
Sbjct: 177 CERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHP-CE------MCPAQPH 229
Query: 278 -CRPDQF-ECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDIS 335
CR G+C +C I G + +N +C KC +G
Sbjct: 230 PCRRGFIPNIRTGAC-QDVDECQAIPGLCQGGNCINTVGSFEC------KCPAGH----- 277
Query: 336 KVCNQEQDCRDWSDEPLKECHINECLVNNGGCSH-ICKDLVIGYECDCAAGFELI-DRKT 393
K+ Q C D I+EC G C C + V Y C C GF D
Sbjct: 278 KLNEVSQKCED----------IDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTR 327
Query: 394 CGDIDECQNPGIC 406
C D+ PG C
Sbjct: 328 CIDV----RPGYC 336
Score = 34.7 bits (78), Expect = 0.40
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 6/36 (16%)
Query: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
C ++C + Y CSCP GY ++E+GR C+
Sbjct: 2455 CNFIC------KNTEGSYQCSCPKGYILQEDGRSCK 2484
Score = 32.7 bits (73), Expect = 1.5
Identities = 15/59 (25%), Positives = 30/59 (50%), Gaps = 8/59 (13%)
Query: 710 MENGGCEYL--CLPAPQI------NDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSE 760
++N CE + C+ P+I ++ + C CP G+++ +GR CQ + Y++
Sbjct: 2006 LQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMSYCYAK 2064
Score = 30.0 bits (66), Expect = 9.8
Identities = 17/53 (32%), Positives = 25/53 (47%), Gaps = 3/53 (5%)
Query: 698 VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
V GKN EDM+ +CL IN+ + C C G+ + +GR C+
Sbjct: 563 VTRDGKNC--EDMDECSIRNMCLNGMCINEDG-SFKCICKPGFQLASDGRYCK 612
>gi|66346695 fibrillin 2 precursor [Homo sapiens]
Length = 2912
Score = 108 bits (271), Expect = 2e-23
Identities = 112/459 (24%), Positives = 169/459 (36%), Gaps = 60/459 (13%)
Query: 32 KCEPSQFQCTNGRCITLL--WKCDGDEDCVDGSDEKNCVK-KTCAESDFVCNNGQCV--P 86
+C+ CT G+C + +KC + +E+NC C S +C +G CV P
Sbjct: 1076 ECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTP 1135
Query: 87 SRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146
++C+ E G + C + + C + S++CD +
Sbjct: 1136 GSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSR 1195
Query: 147 ENCGNIT-CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSC 205
E+C +I CS + C +G+C+ N + Q C+ G E C
Sbjct: 1196 EDCVDINECSLSDNLCRNGKCV--NMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGC 1253
Query: 206 IPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGEC--IHKKWRC---DG 260
+ +CS +L GR +C + C G+C I ++RC DG
Sbjct: 1254 DTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDG 1313
Query: 261 ---DPDCKDGSDEVNCP--SRTCRPDQFECEDGSCI----------HGSRQCNGIRDCVD 305
D K D C S C + E GS I G+ C + +C
Sbjct: 1314 FMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEI 1373
Query: 306 GSDEVNCKNVNQCLG-PGKFKCRSGE--------CIDISKVCNQEQDC------------ 344
G+ NC CL PG FKC E CID+ + N C
Sbjct: 1374 GAH--NCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGS 1431
Query: 345 ------RDWSDEPLKECHINECLVNNGGCSH-ICKDLVIGYECDCAAGFE-LIDRKTCGD 396
++ + ++EC N C + C ++ Y C+C GF D ++C D
Sbjct: 1432 YRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQD 1491
Query: 397 IDECQNPGICS-QICINLKGGYKCECSRGYQMDLATGVC 434
IDEC IC C NL G + C C GY++D G C
Sbjct: 1492 IDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC 1530
Score = 98.6 bits (244), Expect = 2e-20
Identities = 106/404 (26%), Positives = 158/404 (39%), Gaps = 92/404 (22%)
Query: 78 VCNNGQCVPSRWKCDGDPDCE-------DGS-----DESPEQCHMRTCR---IHEISCGA 122
VC NG+CV S+ G CE DG+ D EQC+++ IH +
Sbjct: 965 VCPNGRCVNSK----GSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKF 1020
Query: 123 HSTQC---IPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCIS-RNFVCNGQDD 178
C + +W G + E C E C G + R V G+
Sbjct: 1021 RMDACCCAVGAAW----------GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPF 1070
Query: 179 CSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTK 238
D ++ C A C+ C C S +L+ R +
Sbjct: 1071 YKDINE--------CKAFPGMCTYGKCRNTI----GSFKCRCNSGFALDMEERNCTDIDE 1118
Query: 239 CPASEIQCGSGECIHK--KWRCDGDPDCKDGSDE-----VNCPS-RTCRPDQFECEDGSC 290
C S CGSG C++ + C+ C +G + NC C + C G+C
Sbjct: 1119 CRISPDLCGSGICVNTPGSFECE----CFEGYESGFMMMKNCMDIDECERNPLLCRGGTC 1174
Query: 291 IH--GSRQCNGIRDCVDGSD----EVNCKNVNQCLGPGKFKCRSGECIDISKV----CN- 339
++ GS QC DC G + +C ++N+C CR+G+C+++ CN
Sbjct: 1175 VNTEGSFQC----DCPLGHELSPSREDCVDINECSLSDNL-CRNGKCVNMIGTYQCSCNP 1229
Query: 340 ------QEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRK 392
Q C D I+EC++ NGGC C + YEC C+ G+ L+ D +
Sbjct: 1230 GYQATPDRQGCTD----------IDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGR 1279
Query: 393 TCGDIDECQ-NPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
+C DIDEC+ NP IC C N+ G Y+C C G+ + C
Sbjct: 1280 SCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323
Score = 83.6 bits (205), Expect = 7e-16
Identities = 116/496 (23%), Positives = 172/496 (34%), Gaps = 116/496 (23%)
Query: 40 CTNGRCITLL--WKCDGDEDCVDGSDEKNCVK-KTCAESDFVC--------NNGQCV-PS 87
C NG C ++ ++C+ +E G NC CA++ +C + +C P
Sbjct: 2223 CGNGTCTNVIGSFECNCNEGFEPGP-MMNCEDINECAQNPLLCAFRCMNTFGSYECTCPI 2281
Query: 88 RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC----GAHSTQCIP-VSWRCDGENDCDS 142
+ D DE E H C + C G C P ++ R DGE D
Sbjct: 2282 GYALREDQKMCKDLDECAEGLH--DCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDE 2339
Query: 143 GEDEENCGNITCSPDEFTCSSGRCI----SRNFVCN-GQDDCSDGSDELDCAPPTCGAHE 197
E C C +GRC+ S CN G S G++ LD C A
Sbjct: 2340 NE---------CRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEV 2390
Query: 198 FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHT-------------------- 237
Q + C D QC P+ T
Sbjct: 2391 LQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDI 2450
Query: 238 -KCPASEIQCGSGECIHK--KWRCDGDPDCKDGSD---------EVNCPSRTCRPDQFEC 285
+C C +G+CI+ +RC CK G +++ S++ +P + C
Sbjct: 2451 DECKVMPNLCTNGQCINTMGSFRCF----CKVGYTTDISGTSCIDLDECSQSPKPCNYIC 2506
Query: 286 EDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQC--------------LGPGKFKCRSG-- 329
++ GS QC+ R V D CK++++C LG KC G
Sbjct: 2507 KN---TEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 2563
Query: 330 ----------ECIDISKVCNQEQDCRDWSDEPLKECH--------------INECLVNNG 365
EC +C + C++ EC ++EC N
Sbjct: 2564 QHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-DGNH 2622
Query: 366 GCSHICKDLVIGYECDCAAGF-ELIDRKTCGDIDECQNPGIC-SQICINLKGGYKCECSR 423
C H C++++ GY C C G+ + C D +EC NP C S C N G YKC C
Sbjct: 2623 RCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPS 2682
Query: 424 GYQMDLATGVCKAVGK 439
G+ D + C V +
Sbjct: 2683 GFSFDQFSSACHDVNE 2698
Score = 82.4 bits (202), Expect = 2e-15
Identities = 114/459 (24%), Positives = 168/459 (36%), Gaps = 85/459 (18%)
Query: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGS------DEKNCVKKTCAESDFVCNNGQCV 85
+C + C NGRC+ DG C+ + D KNCV + +C NG C+
Sbjct: 578 ECIQNGVLCKNGRCVNT----DGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCI 633
Query: 86 --PSRWKCDGDPDCEDGSDESPEQCH---MRTCRIHEISCGAHSTQCIPV--SWRCDGEN 138
+KC C+ G +P + + C+ I H CI S+RCD
Sbjct: 634 NEDGSFKCI----CKPGFVLAPNGRYCTDVDECQTPGICMNGH---CINSEGSFRCDCPP 686
Query: 139 DCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHE- 197
G D C + TC G + VC + E CA P G E
Sbjct: 687 GLAVGMDGRVCVDTHMRS---TCYGG---IKKGVCVRPFPGAVTKSECCCANPDYGFGEP 740
Query: 198 -FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGEC--IHK 254
C + +C + + + +C P I C +G C +
Sbjct: 741 CQPCPAKNSAEFHGLCSSGVGITVDGRD-INECALDPDI----------CANGICENLRG 789
Query: 255 KWRCDGDPDCKDGSDEVNCPS-RTCRPDQFECEDGSCIH--GSRQCNGIRDCVDGSDEVN 311
+RC+ + + + NC C ++ C++G C + GS C V ++
Sbjct: 790 SYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETET 849
Query: 312 CKNVNQCLGP-----------GKFKCRSGECIDISKVCNQEQDCRDWSDEPLK-ECHIN- 358
C+++N+C G F C EC SK+ + C D LK C +N
Sbjct: 850 CEDINECESNPCVNGACRNNLGSFNC---ECSPGSKLSSTGLICID----SLKGTCWLNI 902
Query: 359 ---ECLVNNGGC---SHICKDL--VIGYECD-------CAAGFELIDRKTCGDIDECQN- 402
C VN G S C L G C+ C G I TC D++EC+
Sbjct: 903 QDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVF 962
Query: 403 PGICSQ-ICINLKGGYKCECSRGYQMDLATGVCKAVGKE 440
PG+C C+N KG + CEC G +D VC + E
Sbjct: 963 PGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001
Score = 80.9 bits (198), Expect = 5e-15
Identities = 118/470 (25%), Positives = 181/470 (38%), Gaps = 97/470 (20%)
Query: 34 EPSQFQCTNGRCITLLWKCDGDEDCV-----DGSDEKNCVKKTCAESDF--VCNNGQCVP 86
E + C NG C + G +C+ + + +C+ S F VC NG+C
Sbjct: 1937 ECERHPCGNGTCKNTV----GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFN 1992
Query: 87 S--RWKCDGDPDCEDGSDESPE--QC-HMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
+KC C +G + +P+ C C SC + Q + S+RC C
Sbjct: 1993 EIGSFKCL----CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI----CP 2044
Query: 142 SGED--EENCGNIT-CSPDEFTCSSGRCISR--NFVC----------NG-------QDDC 179
G + ENC +I C D C G C + F C NG Q C
Sbjct: 2045 PGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFC 2104
Query: 180 SDGSDELDCAPPTC-GAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQ--C----GRQ 232
+ C+ P + +C S W D + + DE Q C G
Sbjct: 2105 FTNFENGKCSVPKAFNTTKAKCCCSKMPGEGW--GDPCELCPKDDEVAFQDLCPYGHGTV 2162
Query: 233 PVIH------TKCPASEIQCGSGECIHK--KWRCDGDPDCKDGSDEVNCPSRTCRPDQFE 284
P +H +C S C +G+CI+ +RC+ V C
Sbjct: 2163 PSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP 2222
Query: 285 CEDGSCIH--GSRQCNGIRDCVDGSDE---VNCKNVNQCLGPG---KFKCR----SGECI 332
C +G+C + GS +CN C +G + +NC+++N+C F+C S EC
Sbjct: 2223 CGNGTCTNVIGSFECN----CNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECT 2278
Query: 333 -DISKVCNQEQD-CRDWSDEPLKECHINECLVNNGGCSH---ICKDLVIGYECDCAAGF- 386
I ++Q C+D ++EC C +CK+L+ + C C G
Sbjct: 2279 CPIGYALREDQKMCKD----------LDECAEGLHDCESRGMMCKNLIGTFMCICPPGMA 2328
Query: 387 ELIDRKTCGDIDECQN-PGICSQ-ICINLKGGYKCECSRGYQMDLATGVC 434
D + C D +EC+ PGIC C+N+ G Y+CEC+ G+Q + C
Sbjct: 2329 RRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTEC 2378
Score = 78.2 bits (191), Expect = 3e-14
Identities = 97/420 (23%), Positives = 162/420 (38%), Gaps = 84/420 (20%)
Query: 72 CAESDFVCNNGQCVP--SRWKC--------DGDPDCEDGSDESPEQCHMRTCRIHEISCG 121
C +C NG+C+P S ++C D + DC D ++C C
Sbjct: 498 CKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCID-----VDECTSNPCT------- 545
Query: 122 AHSTQCI--PVSWRCDGENDCDSGEDEENCGNIT-CSPDEFTCSSGRCISRNFVCNGQDD 178
+ C+ P S+ C ++ C +I C + C +GRC++ + G
Sbjct: 546 --NGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTD----GSFQ 599
Query: 179 C-SDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDA-DCSDQSDESLEQCGRQPVIH 236
C + EL C H+ +T+ C+ + +D + C + L GR
Sbjct: 600 CICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDV 659
Query: 237 TKCPASEIQCGSGECIHKK--WRCDGDPDCKDGSDEVNCPSRTCRPDQFE-CEDGSCIH- 292
+C I C +G CI+ + +RCD P G D C R + + G C+
Sbjct: 660 DECQTPGI-CMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRP 718
Query: 293 -----------------------------GSRQCNGIRDCVDGSD-EVNCKNVNQC-LGP 321
S + +G+ C G V+ +++N+C L P
Sbjct: 719 FPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGL--CSSGVGITVDGRDINECALDP 776
Query: 322 GKFKCRSGECIDI--SKVCN----QEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV 375
C +G C ++ S CN E D + + EC +N L +NG +C++
Sbjct: 777 DI--CANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNG----LCRNTP 830
Query: 376 IGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVC 434
Y C C G+ + +TC DI+EC++ + C N G + CECS G ++ +C
Sbjct: 831 GSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLIC 890
Score = 68.6 bits (166), Expect = 2e-11
Identities = 57/202 (28%), Positives = 80/202 (39%), Gaps = 33/202 (16%)
Query: 246 CGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQF-ECED-GSCIHGSRQCNGIRDC 303
C +G CI++ GS CP+ D CED C +G C DC
Sbjct: 1819 CANGVCINQI-----------GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADC 1867
Query: 304 VDGSDEVNCK-NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECH------ 356
++ C+ L P EC++I VC+ C D CH
Sbjct: 1868 INSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGL-CVDLQGSYQCICHNGFKAS 1926
Query: 357 --------INECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQN--PGIC 406
++EC + G + CK+ V Y C C GFEL C DIDEC + +C
Sbjct: 1927 QDQTMCMDVDECERHPCG-NGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVC 1985
Query: 407 -SQICINLKGGYKCECSRGYQM 427
+ C N G +KC C+ GY++
Sbjct: 1986 RNGRCFNEIGSFKCLCNEGYEL 2007
Score = 63.9 bits (154), Expect = 6e-10
Identities = 106/456 (23%), Positives = 162/456 (35%), Gaps = 109/456 (23%)
Query: 20 RESGATGTGRKAKCEPSQFQCTNGRCITLL--WKCDGDEDCVDGSDEKNCV--------- 68
R G + +C C NGRC+ ++ ++C+ +E S C+
Sbjct: 2329 RRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFA 2388
Query: 69 -------------KKTCAESDFVCNNG-----QC--VPSRWKCDGDPDCEDGSDESPEQC 108
+ +S+ C+ G QC P C G + +
Sbjct: 2389 EVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR 2448
Query: 109 HMRTCRIHEISCGAHSTQCIPV--SWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRC 166
+ C++ C + QCI S+RC C G + G DE + S C
Sbjct: 2449 DIDECKVMPNLCT--NGQCINTMGSFRCF----CKVGYTTDISGTSCIDLDECSQSPKPC 2502
Query: 167 ISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD-CSDQSDES 225
N++C ++GS +QCS P +V +D C D +
Sbjct: 2503 ---NYICKN----TEGS--------------YQCSC----PRGYVLQEDGKTCKDLDECQ 2537
Query: 226 LEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSR-TCR--PDQ 282
+Q Q + +C G H C + +C GS C ++ C+ P
Sbjct: 2538 TKQHNCQFLCVNTLGGFTCKCPPGFTQHHT-ACIDNNEC--GSQPSLCGAKGICQNTPGS 2594
Query: 283 FECEDGSCIHG-SRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI--SKVCN 339
F CE C G S G+ NC++V++C G +C+ G C +I C
Sbjct: 2595 FSCE---CQRGFSLDATGL----------NCEDVDEC--DGNHRCQHG-CQNILGGYRCG 2638
Query: 340 ------QEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELID-RK 392
Q DE NEC N S C + + Y+C C +GF
Sbjct: 2639 CPQGYIQHYQWNQCVDE-------NECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSS 2691
Query: 393 TCGDIDEC---QNPGICSQICINLKGGYKCECSRGY 425
C D++EC +NP C+ C N +GGY C C GY
Sbjct: 2692 ACHDVNECSSSKNP--CNYGCSNTEGGYLCGCPPGY 2725
Score = 62.8 bits (151), Expect = 1e-09
Identities = 87/334 (26%), Positives = 117/334 (35%), Gaps = 75/334 (22%)
Query: 120 CGAH-STQCIPVSWRCDGENDCDSGEDEENCGNITCS-PDEFTCSSGRCISRNFVCNGQD 177
CG+ + C P G N C +CG+ CS P+ TCSSG+ S
Sbjct: 89 CGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISS--------- 139
Query: 178 DCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHT 237
TCG+ Q + C+ DD C Q CG QPV
Sbjct: 140 --------------TCGSKSIQQCSVRCMNGGTCADDHCQC--QKGYIGTYCG-QPVCEN 182
Query: 238 KCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIH--GSR 295
C G CI RC C G C + + G C ++
Sbjct: 183 GCQ------NGGRCIGPN-RCA----CVYGFTGPQC--------ERDYRTGPCFTQVNNQ 223
Query: 296 QCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKE- 354
C G + + + C + + G C + Q Q CR ++
Sbjct: 224 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPA-----------QPQPCRRGFIPNIRTG 272
Query: 355 -CH-INECLVNNGGCSH-ICKDLVIGYECDCAAGFELIDR-KTCGDIDECQN-PGICSQ- 408
C ++EC G C C + V +EC C AG + + + C DIDEC PGIC
Sbjct: 273 ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332
Query: 409 ICINLKGGYKCECSRGYQ--------MDLATGVC 434
C N G Y C C RGY +D TG+C
Sbjct: 333 ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMC 366
Score = 62.0 bits (149), Expect = 2e-09
Identities = 108/486 (22%), Positives = 170/486 (34%), Gaps = 96/486 (19%)
Query: 21 ESGATGTGRKAKCEP---SQFQ--CTNGRCITL--LWKCDGDEDCVDGSDEKNCVKKTCA 73
E G T C+ FQ C G C L ++ C D+ NC
Sbjct: 1477 EMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC 1536
Query: 74 ESDFVCNNGQCV--PSRWKCDGDPDCEDGS------DESPEQCHMR---------TCRIH 116
C NG CV P R++C+ PD + D C+++ +C
Sbjct: 1537 ADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNT- 1595
Query: 117 EISCGAHSTQC---IPVSWR--CDGENDCDSGEDEENC-GNITCSPDEFT---------- 160
EI G + C + +W C+ +S E C G P+ T
Sbjct: 1596 EIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQ 1655
Query: 161 -----CSSGRCISRNFVCNGQDDCSDG---------SDELD--------CAPPTCGAHEF 198
C G CI N + Q +C G +++D C P TC +
Sbjct: 1656 ELPGLCQGGNCI--NTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTC-YNTL 1712
Query: 199 QCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP--ASEIQCGSGECIHKKW 256
T C P + +C D + + P ++ C + K W
Sbjct: 1713 GNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAW 1772
Query: 257 RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC--IHGSRQCNGIRDCVDGSDEVNCKN 314
+P G+ + F+ G I ++ GI C +G C
Sbjct: 1773 NKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGI--CANGV----C-- 1824
Query: 315 VNQCLGPGKFKCRSGECI-DISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKD 373
+NQ +G + +C +G D+ VC +C + + C N +N+ G
Sbjct: 1825 INQ-IGSFRCECPTGFSYNDLLLVCEDIDECSNGDNL----CQRNADCINSPG------- 1872
Query: 374 LVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQ-ICINLKGGYKCECSRGYQMDLAT 431
Y C+CAAGF+L C D +EC + P +CS +C++L+G Y+C C G++
Sbjct: 1873 ---SYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQ 1929
Query: 432 GVCKAV 437
+C V
Sbjct: 1930 TMCMDV 1935
Score = 54.3 bits (129), Expect = 5e-07
Identities = 59/219 (26%), Positives = 82/219 (37%), Gaps = 33/219 (15%)
Query: 240 PASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDG-SCIHGSRQCN 298
P CG G C C C G C S++ + C +G +C QC
Sbjct: 113 PICRNSCGDGFCSRPNM-CT----CSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQ 167
Query: 299 -GIRDCVDGSD--EVNCKNVNQCLGPGKFKC-------------RSGECIDISKVCNQEQ 342
G G E C+N +C+GP + C R+G C ++V NQ
Sbjct: 168 KGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCF--TQVNNQM- 224
Query: 343 DCRDWSDEPLKECHINECLVNNGGC-SHICKDLVIGYECDCAAGF-ELIDRKTCGDIDEC 400
C+ + C C G H C ++ C GF I C D+DEC
Sbjct: 225 -CQGQLTGIV--CTKTLCCATIGRAWGHPC-EMCPAQPQPCRRGFIPNIRTGACQDVDEC 280
Query: 401 QN-PGICSQ-ICINLKGGYKCECSRGYQMDLATGVCKAV 437
Q PGIC CIN G ++C C G++ T C+ +
Sbjct: 281 QAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDI 319
Score = 34.3 bits (77), Expect = 0.52
Identities = 13/36 (36%), Positives = 20/36 (55%), Gaps = 6/36 (16%)
Query: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
C Y+C + Y CSCP GY ++E+G+ C+
Sbjct: 2502 CNYIC------KNTEGSYQCSCPRGYVLQEDGKTCK 2531
Score = 32.3 bits (72), Expect = 2.0
Identities = 14/38 (36%), Positives = 18/38 (47%), Gaps = 6/38 (15%)
Query: 712 NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
NGGC+ C + Y CSC GY + +GR C
Sbjct: 1250 NGGCDTQC------TNSEGSYECSCSEGYALMPDGRSC 1281
Score = 31.2 bits (69), Expect = 4.4
Identities = 23/83 (27%), Positives = 33/83 (39%), Gaps = 15/83 (18%)
Query: 704 NWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTY----- 758
N C+ED +CL N + C CP G+ + +NGR C T + +
Sbjct: 2058 NECDEDPN------ICLFGSCTNTPGG-FQCLCPPGFVLSDNGRRCFDTRQSFCFTNFEN 2110
Query: 759 ---SETKDTNTTEISATSGLVPG 778
S K NTT+ +PG
Sbjct: 2111 GKCSVPKAFNTTKAKCCCSKMPG 2133
>gi|28557796 low density lipoprotein receptor class A domain
containing 3 [Homo sapiens]
Length = 345
Score = 108 bits (271), Expect = 2e-23
Identities = 50/121 (41%), Positives = 69/121 (57%), Gaps = 15/121 (12%)
Query: 76 DFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCG------AHSTQCIP 129
+F+C+NG+C+P W+CDG PDC D SDE + C + CG A CI
Sbjct: 34 NFMCSNGRCIPGAWQCDGLPDCFDKSDE-------KECPKAKSKCGPTFFPCASGIHCII 86
Query: 130 VSWRCDGENDCDSGEDEENC--GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD 187
+RC+G DC G DEENC + CS + C +G CI ++F+C+GQ++C D SDE
Sbjct: 87 GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
Query: 188 C 188
C
Sbjct: 147 C 147
Score = 105 bits (263), Expect = 1e-22
Identities = 58/149 (38%), Positives = 74/149 (49%), Gaps = 10/149 (6%)
Query: 9 LWLLLALCW----APRESGATGTGRKAKCE-PSQFQCTNGRCITLLWKCDGDEDCVDGSD 63
+WLL LC A G +C P F C+NGRCI W+CDG DC D SD
Sbjct: 1 MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD 60
Query: 64 EKNC--VKKTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
EK C K C + F C +G C+ R++C+G DC DGSDE + C C
Sbjct: 61 EKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC 120
Query: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENC 149
+ CI S+ CDG+N+C DEE+C
Sbjct: 121 --KNGLCIDKSFICDGQNNCQDNSDEESC 147
Score = 103 bits (257), Expect = 7e-22
Identities = 49/108 (45%), Positives = 61/108 (56%), Gaps = 3/108 (2%)
Query: 246 CGSGECIHKKWRCDGDPDCKDGSDEVNCPSRT--CRPDQFECEDG-SCIHGSRQCNGIRD 302
C +G CI W+CDG PDC D SDE CP C P F C G CI G +CNG D
Sbjct: 37 CSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFED 96
Query: 303 CVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
C DGSDE NC ++ C++G CID S +C+ + +C+D SDE
Sbjct: 97 CPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144
Score = 98.6 bits (244), Expect = 2e-20
Identities = 50/120 (41%), Positives = 69/120 (57%), Gaps = 8/120 (6%)
Query: 198 FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG-ECIHKKW 256
F CS CIP +W CD DC D+SDE ++C P +KC + C SG CI ++
Sbjct: 35 FMCSNGRCIPGAWQCDGLPDCFDKSDE--KEC---PKAKSKCGPTFFPCASGIHCIIGRF 89
Query: 257 RCDGDPDCKDGSDEVNCPSRT--CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKN 314
RC+G DC DGSDE NC + C ++ C++G CI S C+G +C D SDE +C++
Sbjct: 90 RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149
Score = 96.7 bits (239), Expect = 8e-20
Identities = 46/113 (40%), Positives = 60/113 (53%), Gaps = 5/113 (4%)
Query: 126 QCIPVSWRCDGENDCDSGEDEENC--GNITCSPDEFTCSSG-RCISRNFVCNGQDDCSDG 182
+CIP +W+CDG DC DE+ C C P F C+SG CI F CNG +DC DG
Sbjct: 41 RCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDG 100
Query: 183 SDELDCA--PPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQP 233
SDE +C P C + C CI S++CD +C D SDE + ++P
Sbjct: 101 SDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEP 153
Score = 92.4 bits (228), Expect = 2e-18
Identities = 50/123 (40%), Positives = 66/123 (53%), Gaps = 8/123 (6%)
Query: 156 PDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC--APPTCGAHEFQCSTS-SCIPISWVC 212
P F CS+GRCI + C+G DC D SDE +C A CG F C++ CI + C
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
Query: 213 DDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVN 272
+ DC D SDE E C P++ C + C +G CI K + CDG +C+D SDE +
Sbjct: 92 NGFEDCPDGSDE--ENCTANPLL---CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146
Query: 273 CPS 275
C S
Sbjct: 147 CES 149
Score = 67.4 bits (163), Expect = 6e-11
Identities = 47/133 (35%), Positives = 61/133 (45%), Gaps = 18/133 (13%)
Query: 280 PDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG-ECIDISKVC 338
P F C +G CI G+ QC+G+ DC D SDE C GP F C SG CI C
Sbjct: 32 PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91
Query: 339 NQEQDCRDWSDEPLKECHINECLVN-------NGGCSHICKDLVIGYECDCAAGFELIDR 391
N +DC D SDE + C N L + NG C I K + + +C + D
Sbjct: 92 NGFEDCPDGSDE--ENCTANPLLCSTARYHCKNGLC--IDKSFICDGQNNCQ---DNSDE 144
Query: 392 KTCGDIDECQNPG 404
++C + Q PG
Sbjct: 145 ESC---ESSQEPG 154
Score = 41.6 bits (96), Expect = 0.003
Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 10/104 (9%)
Query: 316 NQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC--HINECLVNNGGCSHICKD 373
N+C PG F C +G CI + C+ DC D SDE KEC ++C C+
Sbjct: 27 NECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDE--KECPKAKSKCGPTFFPCASGIHC 84
Query: 374 LVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQICINLKGG 416
++ + C+ GFE D D + C NP +CS + K G
Sbjct: 85 IIGRFRCN---GFE--DCPDGSDEENCTANPLLCSTARYHCKNG 123
>gi|7706111 8D6 antigen [Homo sapiens]
Length = 282
Score = 107 bits (266), Expect = 6e-23
Identities = 55/143 (38%), Positives = 70/143 (48%), Gaps = 12/143 (8%)
Query: 19 PRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDF 77
P + A G C P++FQC T+G C+ L W+CD D DC DGSDE+ C + C +
Sbjct: 41 PTSAQAAGPS-SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQ--- 96
Query: 78 VCNNGQCVPS---RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRC 134
GQC P C G DC G+D+ C C E+ C S CIP++WRC
Sbjct: 97 ---KGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRC 152
Query: 135 DGENDCDSGEDEENCGNITCSPD 157
DG DC DE CG P+
Sbjct: 153 DGHPDCPDSSDELGCGTNEILPE 175
Score = 92.8 bits (229), Expect = 1e-18
Identities = 50/131 (38%), Positives = 68/131 (51%), Gaps = 10/131 (7%)
Query: 153 TCSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWV 211
+C P +F C +SG C+ + C+ DCSDGSDE +C C + QC +P
Sbjct: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-TQKGQCPPPPGLPCP-- 109
Query: 212 CDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG-SGECIHKKWRCDGDPDCKDGSDE 270
C +DCS +D+ L C R C A E++C S +CI WRCDG PDC D SDE
Sbjct: 110 CTGVSDCSGGTDKKLRNCSR-----LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164
Query: 271 VNCPSRTCRPD 281
+ C + P+
Sbjct: 165 LGCGTNEILPE 175
Score = 77.0 bits (188), Expect = 7e-14
Identities = 49/137 (35%), Positives = 66/137 (48%), Gaps = 19/137 (13%)
Query: 192 TCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHT-KCPASE-IQCGS 248
+C +FQC TS C+P++W CD D DCSD SDE E+C +P +CP + C
Sbjct: 53 SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE--EECRIEPCTQKGQCPPPPGLPCP- 109
Query: 249 GECIHKKWRCDGDPDCKDGSDEV--NCPSRTCRPDQFECE-DGSCIHGSRQCNGIRDCVD 305
C G DC G+D+ NC C + C CI + +C+G DC D
Sbjct: 110 ---------CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD 160
Query: 306 GSDEVNCKNVNQCLGPG 322
SDE+ C N+ L G
Sbjct: 161 SSDELGC-GTNEILPEG 176
Score = 74.3 bits (181), Expect = 5e-13
Identities = 49/130 (37%), Positives = 63/130 (48%), Gaps = 17/130 (13%)
Query: 239 CPASEIQCG-SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSR-- 295
CP ++ QC SG C+ WRCD D DC DGSDE C C + G C
Sbjct: 54 CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT------QKGQCPPPPGLP 107
Query: 296 -QCNGIRDCVDGSDEV--NCKNVNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDEP 351
C G+ DC G+D+ NC + CL G+ +C S +CI ++ C+ DC D SDE
Sbjct: 108 CPCTGVSDCSGGTDKKLRNCSRL-ACLA-GELRCTLSDDCIPLTWRCDGHPDCPDSSDE- 164
Query: 352 LKECHINECL 361
C NE L
Sbjct: 165 -LGCGTNEIL 173
Score = 48.9 bits (115), Expect = 2e-05
Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 6/108 (5%)
Query: 275 SRTCRPDQFECE-DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECID 333
S +C P +F+C G C+ + +C+ DC DGSDE C+ + C G+ G
Sbjct: 51 SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR-IEPCTQKGQCPPPPG---- 105
Query: 334 ISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECD 381
+ C DC +D+ L+ C CL C+ + + + CD
Sbjct: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCD 153
>gi|46249414 latent transforming growth factor beta binding protein 1
isoform LTBP-1L [Homo sapiens]
Length = 1722
Score = 105 bits (261), Expect = 2e-22
Identities = 96/375 (25%), Positives = 151/375 (40%), Gaps = 56/375 (14%)
Query: 113 CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNIT-CSPDEFTCSSGRCISR-- 169
C ++ CGA +PV + C E + C +I C+ + CS GRC +
Sbjct: 878 CTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEG 937
Query: 170 NFVC------NGQDDCSDGSDELDCAPP----------TCGAHEFQ-CSTSSCIPISWVC 212
+F+C ++ ++ D +C P T GA + C + + C
Sbjct: 938 SFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRC 997
Query: 213 DDDADCSDQSDESLEQCGRQPVIHTKCPASEI------QC-GSGECIHKKWRCDGDPDCK 265
+D +C + S EQC P + P +E QC EC+ +GD
Sbjct: 998 EDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNL 1057
Query: 266 DGSDEVNCPSRTCR-PDQFECED-GSCIHGSRQCNGIRDCVDGSDEVNC----------- 312
+GS +C R PD C D C G+ NG +GS C
Sbjct: 1058 EGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKD 1117
Query: 313 --KNVNQCLGPGKFKCRSGECIDISK----VCNQEQDCRDWSDEPLKECH-INECLVNNG 365
+++++C + C G+C + VC+Q D C INECL +
Sbjct: 1118 QCEDIDEC--QHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDH----CEDINECLEDKS 1171
Query: 366 GCSH-ICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQ--ICINLKGGYKCECS 422
C C + Y+C C GF+L D KTC DI+EC++PG+C C+N +G + C C
Sbjct: 1172 VCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQ 1231
Query: 423 RGYQMDLATGVCKAV 437
+G+ + C+ +
Sbjct: 1232 QGFSISADGRTCEDI 1246
Score = 93.2 bits (230), Expect = 9e-19
Identities = 118/460 (25%), Positives = 181/460 (39%), Gaps = 103/460 (22%)
Query: 32 KCEPSQFQCTNGRCI----TLLWKC-------DGDEDCVDGSD--------EKNCVKKTC 72
+C Q C+ GRC + L C + +C+D + E +CV
Sbjct: 919 ECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVG 978
Query: 73 AESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC----GAHSTQCI 128
A C++G + R +C+ +C + S EQC + C + QC+
Sbjct: 979 AFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCL 1038
Query: 129 PVSWRCDGENDCDSGEDEENCGNITCS--------PDEFTCSS-GRCISRNFVCNGQDDC 179
V C N C +G+ G+ CS PD C C N NGQ C
Sbjct: 1039 DVD-ECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQ--C 1095
Query: 180 SDGSDELDCAPPTCG-AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQC-GRQPVIHT 237
+ C TCG ++ + C E +++C R H
Sbjct: 1096 KNTEGSFRC---TCGQGYQLSAAKDQC------------------EDIDECQHRHLCAHG 1134
Query: 238 KCPASEIQCGSGECI-HKKWRCDGDPD-CKDGSDEVNCPSRTCRPDQFECEDGSCIH--G 293
+C +E GS +C+ + +R G D C+D ++ C D+ C+ G CI+ G
Sbjct: 1135 QCRNTE---GSFQCVCDQGYRASGLGDHCEDINE--------CLEDKSVCQRGDCINTAG 1183
Query: 294 SRQCNGIRDCVDG---SDEVNCKNVNQCLGPGKFKCRSGECIDISK----VCNQ----EQ 342
S C C DG D C+++N+C PG GEC++ VC Q
Sbjct: 1184 SYDCT----CPDGFQLDDNKTCQDINECEHPG-LCGPQGECLNTEGSFHCVCQQGFSISA 1238
Query: 343 DCRDWSDEPLKECHINECLVNNGGC-SH-ICKDLVIGYECDCAAGFEL-IDRKTCGDIDE 399
D R D I+EC VNN C SH C + + C C GF+ D + C D++E
Sbjct: 1239 DGRTCED-------IDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNE 1290
Query: 400 CQ-NPGICSQ-ICINLKGGYKCECS-RGYQMDLATGVCKA 436
C+ G+C + C N++G + C C+ + TG C++
Sbjct: 1291 CELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1330
Score = 58.9 bits (141), Expect = 2e-08
Identities = 104/469 (22%), Positives = 157/469 (33%), Gaps = 84/469 (17%)
Query: 40 CTNGRCITL--LWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS----RWKCDG 93
C NG C L + C + D K+C + +C NGQC + R C
Sbjct: 1049 CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQ 1108
Query: 94 DPDCEDGSD--ESPEQC-HMRTCRIHEISCGAHSTQCI-PVSWRCDGEND---------- 139
D E ++C H C + S QC+ +R G D
Sbjct: 1109 GYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLE 1168
Query: 140 ----CDSGEDEENCGNITCS-PDEF------TCSSGRCISRNFVCNGQDDCSDGSDELDC 188
C G+ G+ C+ PD F TC +C Q +C + C
Sbjct: 1169 DKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHC 1228
Query: 189 APP---TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE---------SLEQCGRQPVIH 236
+ A C + VCD C + + Q G+ V
Sbjct: 1229 VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDV 1288
Query: 237 TKCPASEIQCGSGEC--IHKKWRCDGDPDCKDGSDEVN-----CPSRTCRP-----DQFE 284
+C CG C + + C C D + E + C SRT DQ +
Sbjct: 1289 NECELLSGVCGEAFCENVEGSFLCV----CADENQEYSPMTGQCRSRTSTDLDVDVDQPK 1344
Query: 285 CEDGSC---IHGSRQCNGIRD---------CVDGSDEVNCKNVNQC--LGPGKFK--CRS 328
E C ++ + C+ + C G+ + + C LG +F C
Sbjct: 1345 EEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPK 1404
Query: 329 GECIDISKVCNQEQDCRDWSDEPLKECHI-NECLVNNGGCSHICKDLVIGYECDCAAGFE 387
G+ + + E ++ D EC + + + NG C + GYEC C G
Sbjct: 1405 GKGFVPAGESSSEAGGENYKDAD--ECLLFGQEICKNG----FCLNTRPGYECYCKQGTY 1458
Query: 388 LIDRKT-CGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
K C D+DECQ+P C C+N +G Y C C+ +D + C
Sbjct: 1459 YDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRC 1507
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/103 (33%), Positives = 46/103 (44%), Gaps = 9/103 (8%)
Query: 332 IDISKVCNQEQD---CRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFEL 388
+D S+ E D +D +E EC + NG + C + GY CDC G+ L
Sbjct: 1595 VDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHL 1654
Query: 389 IDRK-TCGDIDEC----QNPGICSQI-CINLKGGYKCECSRGY 425
K TC D++EC +C CIN G YKC C GY
Sbjct: 1655 DTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGY 1697
Score = 47.0 bits (110), Expect = 8e-05
Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 1/55 (1%)
Query: 381 DCAAGFELIDRKTCGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
+C G++ ++ C DI+ECQ G+C + C+N G Y+C C G+ D C
Sbjct: 611 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665
Score = 38.9 bits (89), Expect = 0.021
Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Query: 386 FELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK 439
FE + + CG ++ C+N C+ ++ GY C+C GY +D A C V +
Sbjct: 1618 FEELQAEECGILNGCENGR-----CVRVQEGYTCDCFDGYHLDTAKMTCVDVNE 1666
Score = 30.8 bits (68), Expect = 5.7
Identities = 28/102 (27%), Positives = 37/102 (36%), Gaps = 26/102 (25%)
Query: 230 GRQPVIHTKCPASEIQCGSGEC--IHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECED 287
GRQ V+ +K P E Q G G +H+K + G C
Sbjct: 135 GRQ-VVRSKVP-QETQSGGGSRLQVHQKQQLQGVNVC----------------------G 170
Query: 288 GSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG 329
G C HG + G + C S C+N CL P C+ G
Sbjct: 171 GRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPG 212
>gi|46249412 latent transforming growth factor beta binding protein
1 isoform LTBP-1S [Homo sapiens]
Length = 1396
Score = 105 bits (261), Expect = 2e-22
Identities = 96/375 (25%), Positives = 151/375 (40%), Gaps = 56/375 (14%)
Query: 113 CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNIT-CSPDEFTCSSGRCISR-- 169
C ++ CGA +PV + C E + C +I C+ + CS GRC +
Sbjct: 552 CTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEG 611
Query: 170 NFVC------NGQDDCSDGSDELDCAPP----------TCGAHEFQ-CSTSSCIPISWVC 212
+F+C ++ ++ D +C P T GA + C + + C
Sbjct: 612 SFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRC 671
Query: 213 DDDADCSDQSDESLEQCGRQPVIHTKCPASEI------QC-GSGECIHKKWRCDGDPDCK 265
+D +C + S EQC P + P +E QC EC+ +GD
Sbjct: 672 EDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNL 731
Query: 266 DGSDEVNCPSRTCR-PDQFECED-GSCIHGSRQCNGIRDCVDGSDEVNC----------- 312
+GS +C R PD C D C G+ NG +GS C
Sbjct: 732 EGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKD 791
Query: 313 --KNVNQCLGPGKFKCRSGECIDISK----VCNQEQDCRDWSDEPLKECH-INECLVNNG 365
+++++C + C G+C + VC+Q D C INECL +
Sbjct: 792 QCEDIDEC--QHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDH----CEDINECLEDKS 845
Query: 366 GCSH-ICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQ--ICINLKGGYKCECS 422
C C + Y+C C GF+L D KTC DI+EC++PG+C C+N +G + C C
Sbjct: 846 VCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQ 905
Query: 423 RGYQMDLATGVCKAV 437
+G+ + C+ +
Sbjct: 906 QGFSISADGRTCEDI 920
Score = 93.2 bits (230), Expect = 9e-19
Identities = 118/460 (25%), Positives = 181/460 (39%), Gaps = 103/460 (22%)
Query: 32 KCEPSQFQCTNGRCI----TLLWKC-------DGDEDCVDGSD--------EKNCVKKTC 72
+C Q C+ GRC + L C + +C+D + E +CV
Sbjct: 593 ECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVG 652
Query: 73 AESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC----GAHSTQCI 128
A C++G + R +C+ +C + S EQC + C + QC+
Sbjct: 653 AFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCL 712
Query: 129 PVSWRCDGENDCDSGEDEENCGNITCS--------PDEFTCSS-GRCISRNFVCNGQDDC 179
V C N C +G+ G+ CS PD C C N NGQ C
Sbjct: 713 DVD-ECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQ--C 769
Query: 180 SDGSDELDCAPPTCG-AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQC-GRQPVIHT 237
+ C TCG ++ + C E +++C R H
Sbjct: 770 KNTEGSFRC---TCGQGYQLSAAKDQC------------------EDIDECQHRHLCAHG 808
Query: 238 KCPASEIQCGSGECI-HKKWRCDGDPD-CKDGSDEVNCPSRTCRPDQFECEDGSCIH--G 293
+C +E GS +C+ + +R G D C+D ++ C D+ C+ G CI+ G
Sbjct: 809 QCRNTE---GSFQCVCDQGYRASGLGDHCEDINE--------CLEDKSVCQRGDCINTAG 857
Query: 294 SRQCNGIRDCVDG---SDEVNCKNVNQCLGPGKFKCRSGECIDISK----VCNQ----EQ 342
S C C DG D C+++N+C PG GEC++ VC Q
Sbjct: 858 SYDCT----CPDGFQLDDNKTCQDINECEHPG-LCGPQGECLNTEGSFHCVCQQGFSISA 912
Query: 343 DCRDWSDEPLKECHINECLVNNGGC-SH-ICKDLVIGYECDCAAGFEL-IDRKTCGDIDE 399
D R D I+EC VNN C SH C + + C C GF+ D + C D++E
Sbjct: 913 DGRTCED-------IDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNE 964
Query: 400 CQ-NPGICSQ-ICINLKGGYKCECS-RGYQMDLATGVCKA 436
C+ G+C + C N++G + C C+ + TG C++
Sbjct: 965 CELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1004
Score = 58.9 bits (141), Expect = 2e-08
Identities = 104/469 (22%), Positives = 157/469 (33%), Gaps = 84/469 (17%)
Query: 40 CTNGRCITL--LWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS----RWKCDG 93
C NG C L + C + D K+C + +C NGQC + R C
Sbjct: 723 CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQ 782
Query: 94 DPDCEDGSD--ESPEQC-HMRTCRIHEISCGAHSTQCI-PVSWRCDGEND---------- 139
D E ++C H C + S QC+ +R G D
Sbjct: 783 GYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLE 842
Query: 140 ----CDSGEDEENCGNITCS-PDEF------TCSSGRCISRNFVCNGQDDCSDGSDELDC 188
C G+ G+ C+ PD F TC +C Q +C + C
Sbjct: 843 DKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHC 902
Query: 189 APP---TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE---------SLEQCGRQPVIH 236
+ A C + VCD C + + Q G+ V
Sbjct: 903 VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDV 962
Query: 237 TKCPASEIQCGSGEC--IHKKWRCDGDPDCKDGSDEVN-----CPSRTCRP-----DQFE 284
+C CG C + + C C D + E + C SRT DQ +
Sbjct: 963 NECELLSGVCGEAFCENVEGSFLCV----CADENQEYSPMTGQCRSRTSTDLDVDVDQPK 1018
Query: 285 CEDGSC---IHGSRQCNGIRD---------CVDGSDEVNCKNVNQC--LGPGKFK--CRS 328
E C ++ + C+ + C G+ + + C LG +F C
Sbjct: 1019 EEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPK 1078
Query: 329 GECIDISKVCNQEQDCRDWSDEPLKECHI-NECLVNNGGCSHICKDLVIGYECDCAAGFE 387
G+ + + E ++ D EC + + + NG C + GYEC C G
Sbjct: 1079 GKGFVPAGESSSEAGGENYKDAD--ECLLFGQEICKNG----FCLNTRPGYECYCKQGTY 1132
Query: 388 LIDRKT-CGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
K C D+DECQ+P C C+N +G Y C C+ +D + C
Sbjct: 1133 YDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRC 1181
Score = 52.8 bits (125), Expect = 1e-06
Identities = 35/103 (33%), Positives = 46/103 (44%), Gaps = 9/103 (8%)
Query: 332 IDISKVCNQEQD---CRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFEL 388
+D S+ E D +D +E EC + NG + C + GY CDC G+ L
Sbjct: 1269 VDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHL 1328
Query: 389 IDRK-TCGDIDEC----QNPGICSQI-CINLKGGYKCECSRGY 425
K TC D++EC +C CIN G YKC C GY
Sbjct: 1329 DTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGY 1371
Score = 47.0 bits (110), Expect = 8e-05
Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 1/55 (1%)
Query: 381 DCAAGFELIDRKTCGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
+C G++ ++ C DI+ECQ G+C + C+N G Y+C C G+ D C
Sbjct: 285 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339
Score = 38.9 bits (89), Expect = 0.021
Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 5/54 (9%)
Query: 386 FELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK 439
FE + + CG ++ C+N C+ ++ GY C+C GY +D A C V +
Sbjct: 1292 FEELQAEECGILNGCENGR-----CVRVQEGYTCDCFDGYHLDTAKMTCVDVNE 1340
>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
Length = 988
Score = 103 bits (257), Expect = 7e-22
Identities = 117/445 (26%), Positives = 167/445 (37%), Gaps = 113/445 (25%)
Query: 1 MGTSAL-WALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCV 59
MG +A+ W L +LLAL R +G +G L D DE C
Sbjct: 1 MGAAAVRWHLCVLLALGTRGRLAGGSG---------------------LPGSVDVDE-CS 38
Query: 60 DGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCH-MRTCRIHEI 118
+G+D+ D +C N P +KC C+ G +QC + C
Sbjct: 39 EGTDD--------CHIDAICQN---TPKSYKCL----CKPGYKGEGKQCEDIDECENDYY 83
Query: 119 SCGA-HSTQCIPVSWRC----------DGENDCDSGEDEENCGNIT--C--SPDEFTCSS 163
+ G H IP ++RC DG N D E ++N G C + + C
Sbjct: 84 NGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYEC-- 141
Query: 164 GRCISRNFVCNGQDDCSDGSDE-LDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQS 222
+C S F+ + Q C S+E ++C G C + ++ C D +
Sbjct: 142 -QCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHI-CRETPKGGVACDCRPGFDLAQNQ 199
Query: 223 DESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSD-EVNCPSRTCRPD 281
+ C G+G C H D P C ++ RTC
Sbjct: 200 KDCTLTCNY---------------GNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE- 243
Query: 282 QFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQE 341
+C + C+ R C D + V C C G +
Sbjct: 244 -------TCAVNNGGCD--RTCKDTATGVRCS------------CPVGFTLQ-----PDG 277
Query: 342 QDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDEC 400
+ C+D INECLVNNGGC H C++ V +EC C G++L+ D +TC DIDEC
Sbjct: 278 KTCKD----------INECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC 327
Query: 401 QNPGICSQICINLKGGYKCECSRGY 425
C ICIN G ++C C RGY
Sbjct: 328 SFERTCDHICINSPGSFQCLCHRGY 352
Score = 37.0 bits (84), Expect = 0.080
Identities = 19/69 (27%), Positives = 29/69 (42%), Gaps = 6/69 (8%)
Query: 707 EEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNT 766
E M NG C+ C+ + Y C CP G + NG+DC T ++ ++T
Sbjct: 365 ECSMSNGSCDQGCV------NTKGSYECVCPPGRRLHWNGKDCVETGKCLSRAKTSPRAQ 418
Query: 767 TEISATSGL 775
S G+
Sbjct: 419 LSCSKAGGV 427
Score = 36.2 bits (82), Expect = 0.14
Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 6/44 (13%)
Query: 706 CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
CE D NGGC + C+ P Y C+C G+ + +G +C
Sbjct: 78 CENDYYNGGCVHECINIP------GNYRCTCFDGFMLAHDGHNC 115
Score = 33.5 bits (75), Expect = 0.88
Identities = 13/41 (31%), Positives = 22/41 (53%), Gaps = 6/41 (14%)
Query: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
+ NGGC+ C D + CSCP G+ ++ +G+ C+
Sbjct: 247 VNNGGCDRTC------KDTATGVRCSCPVGFTLQPDGKTCK 281
Score = 32.3 bits (72), Expect = 2.0
Identities = 18/57 (31%), Positives = 27/57 (47%), Gaps = 11/57 (19%)
Query: 698 VQPSGKNWCEEDME----NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
+QP GK C++ E NGGC++ C + + C C GY + + R CQ
Sbjct: 273 LQPDGKT-CKDINECLVNNGGCDHFC------RNTVGSFECGCRKGYKLLTDERTCQ 322
Score = 31.6 bits (70), Expect = 3.4
Identities = 14/44 (31%), Positives = 23/44 (52%), Gaps = 8/44 (18%)
Query: 706 CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
C+++ NGGC+ +C+ A Y C C SG+ + +N C
Sbjct: 121 CQDN--NGGCQQICVNA------MGSYECQCHSGFFLSDNQHTC 156
Score = 30.4 bits (67), Expect = 7.5
Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 6/41 (14%)
Query: 712 NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQST 752
NGGC++ C + D P TC C Y + +GR C T
Sbjct: 210 NGGCQHSC----EDTDTGP--TCGCHQKYALHSDGRTCIET 244
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.444
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,560,945
Number of Sequences: 37866
Number of extensions: 2113888
Number of successful extensions: 10036
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 138
Number of HSP's successfully gapped in prelim test: 269
Number of HSP's that attempted gapping in prelim test: 4386
Number of HSP's gapped (non-prelim): 2453
length of query: 873
length of database: 18,247,518
effective HSP length: 111
effective length of query: 762
effective length of database: 14,044,392
effective search space: 10701826704
effective search space used: 10701826704
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.