Guide to the Human Genome
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Search of human proteins with 65301164

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|65301164 very low density lipoprotein receptor isoform b
[Homo sapiens]
         (845 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|65301164 very low density lipoprotein receptor isoform b [Hom...  1820   0.0  
gi|65301167 very low density lipoprotein receptor isoform a [Hom...  1802   0.0  
gi|4504975 low density lipoprotein receptor precursor [Homo sapi...   880   0.0  
gi|61744471 low density lipoprotein receptor-related protein 8 i...   832   0.0  
gi|65301119 low density lipoprotein receptor-related protein 8 i...   832   0.0  
gi|61744467 low density lipoprotein receptor-related protein 8 i...   696   0.0  
gi|157384998 low density lipoprotein receptor-related protein 4 ...   602   e-172
gi|66082554 low density lipoprotein receptor-related protein 8 i...   592   e-169
gi|126012562 low density lipoprotein-related protein 1 [Homo sap...   540   e-153
gi|126012573 low density lipoprotein-related protein 2 [Homo sap...   522   e-148
gi|93102379 low density lipoprotein-related protein 1B precursor...   518   e-146
gi|4507157 sortilin-related receptor containing LDLR class A rep...   252   1e-66
gi|119709832 low density lipoprotein receptor-related protein 5 ...   246   5e-65
gi|148727288 low density lipoprotein receptor-related protein 6 ...   242   1e-63
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa...   217   4e-56
gi|134031945 SCO-spondin [Homo sapiens]                               181   3e-45
gi|29244926 corin [Homo sapiens]                                      177   3e-44
gi|11415040 matriptase [Homo sapiens]                                 145   2e-34
gi|115298674 nidogen 1 precursor [Homo sapiens]                       137   4e-32
gi|144953895 nidogen 2 precursor [Homo sapiens]                       133   8e-31
gi|32698824 low density lipoprotein receptor-related protein 5-l...   126   1e-28
gi|209447022 low density lipoprotein receptor-related protein 5-...   126   1e-28
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]            122   1e-27
gi|24430141 fibrillin 1 precursor [Homo sapiens]                      118   2e-26
gi|66346695 fibrillin 2 precursor [Homo sapiens]                      108   2e-23
gi|28557796 low density lipoprotein receptor class A domain cont...   108   2e-23
gi|7706111 8D6 antigen [Homo sapiens]                                 107   6e-23
gi|46249414 latent transforming growth factor beta binding prote...   105   2e-22
gi|46249412 latent transforming growth factor beta binding prote...   105   2e-22
gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]    103   7e-22

>gi|65301164 very low density lipoprotein receptor isoform b [Homo
           sapiens]
          Length = 845

 Score = 1820 bits (4713), Expect = 0.0
 Identities = 845/845 (100%), Positives = 845/845 (100%)

Query: 1   MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 60
           MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
Sbjct: 1   MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 60

Query: 61  GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
           GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
Sbjct: 61  GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120

Query: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180
           GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
Sbjct: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180

Query: 181 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240
           DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
Sbjct: 181 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240

Query: 241 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300
           ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
Sbjct: 241 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300

Query: 301 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 360
           RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
Sbjct: 301 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 360

Query: 361 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 420
           LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
Sbjct: 361 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 420

Query: 421 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480
           CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
Sbjct: 421 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480

Query: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 540
           QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 540

Query: 541 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
           TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
Sbjct: 541 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600

Query: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
           WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
Sbjct: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660

Query: 661 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 720
           DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
Sbjct: 661 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 720

Query: 721 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL 780
           PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL
Sbjct: 721 PAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAILPLLLL 780

Query: 781 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST 840
           VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST
Sbjct: 781 VMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVST 840

Query: 841 DDDLA 845
           DDDLA
Sbjct: 841 DDDLA 845


>gi|65301167 very low density lipoprotein receptor isoform a [Homo
           sapiens]
          Length = 873

 Score = 1802 bits (4668), Expect = 0.0
 Identities = 844/873 (96%), Positives = 844/873 (96%), Gaps = 28/873 (3%)

Query: 1   MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 60
           MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD
Sbjct: 1   MGTSALWALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVD 60

Query: 61  GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
           GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC
Sbjct: 61  GSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120

Query: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180
           GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS
Sbjct: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCS 180

Query: 181 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240
           DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP
Sbjct: 181 DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240

Query: 241 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300
           ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI
Sbjct: 241 ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300

Query: 301 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 360
           RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC
Sbjct: 301 RDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINEC 360

Query: 361 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 420
           LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE
Sbjct: 361 LVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCE 420

Query: 421 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480
           CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA
Sbjct: 421 CSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAA 480

Query: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 540
           QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA
Sbjct: 481 QKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVA 540

Query: 541 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
           TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ
Sbjct: 541 TLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600

Query: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
           WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI
Sbjct: 601 WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660

Query: 661 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 720
           DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL
Sbjct: 661 DGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL 720

Query: 721 PAPQINDHSPKYTCSCPSGYNVEENGRDCQR----------------------------I 752
           PAPQINDHSPKYTCSCPSGYNVEENGRDCQ                             I
Sbjct: 721 PAPQINDHSPKYTCSCPSGYNVEENGRDCQSTATTVTYSETKDTNTTEISATSGLVPGGI 780

Query: 753 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 812
           NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT
Sbjct: 781 NVTTAVSEVSVPPKGTSAAWAILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKT 840

Query: 813 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 845
           TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA
Sbjct: 841 TEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 873


>gi|4504975 low density lipoprotein receptor precursor [Homo
           sapiens]
          Length = 860

 Score =  880 bits (2275), Expect = 0.0
 Identities = 412/840 (49%), Positives = 538/840 (64%), Gaps = 72/840 (8%)

Query: 72  CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVS 131
           C  ++F C +G+C+  +W CDG  +C+DGSDES E C   TC+  + SCG    +CIP  
Sbjct: 27  CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQF 86

Query: 132 WRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPP 191
           WRCDG+ DCD+G DE+ C   TCS DEF C  G+CISR FVC+   DC DGSDE  C   
Sbjct: 87  WRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL 146

Query: 192 TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH---TKCPASEIQCGS 248
           TCG   FQC++S+CIP  W CD+D DC D SDE  ++C    V     + C A E  C S
Sbjct: 147 TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLS 206

Query: 249 GECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSD 308
           GECIH  WRCDG PDCKD SDE NC   TCRPD+F+C DG+CIHGSRQC+   DC D SD
Sbjct: 207 GECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSD 266

Query: 309 EVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCS 368
           EV C NV  C GP KFKC SGECI + KVCN  +DCRDWSDEP+KEC  NECL NNGGCS
Sbjct: 267 EVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCS 326

Query: 369 HICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMD 428
           H+C DL IGYEC C  GF+L+ ++ C DIDECQ+P  CSQ+C+NL+GGYKC+C  G+Q+D
Sbjct: 327 HVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLD 386

Query: 429 LATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADL 488
             T  CKAVG    L FTNR ++RK+ L+R EY  L+  LRN VALD ++A+ +++W+DL
Sbjct: 387 PHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDL 446

Query: 489 SQKAIFSASIDDKVGRHVKMIDNVYN-----PAAIAVDWVYKTIYWTDAASKTISVATLD 543
           SQ+ I S  +D   G  V   D V +     P  +AVDW++  IYWTD+   T+SVA   
Sbjct: 447 SQRMICSTQLDRAHG--VSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTK 504

Query: 544 GTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPN 603
           G KRK LF  +  +P +I VDP+ GF+YW+DWG PAKI+K G+NG D   LVT +IQWPN
Sbjct: 505 GVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPN 564

Query: 604 GITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGE 663
           GITLDL+  RLYW+DSKLH +SS+D+NG +R+ +L+  + LAHP +L +FED+V+W D  
Sbjct: 565 GITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII 624

Query: 664 NEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEE-DMENGGCEYLCLPA 722
           NEA++ AN+ TGS++  L  NL   +D++++H L QP G NWCE   + NGGC+YLCLPA
Sbjct: 625 NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPA 684

Query: 723 PQINDHSPKYTCSCPSGYNVEENGRDC-----------QRINVTTAVSEVSVPPKGT--- 768
           PQIN HSPK+TC+CP G  +  + R C           +   V   VS  +V  + T   
Sbjct: 685 PQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTR 744

Query: 769 ----------------------------------------SAAWAILPLLLLVM---AAV 785
                                                   S+  A+  +L +V+     +
Sbjct: 745 PVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL 804

Query: 786 GGYLMWRNWQHKNMKSMNFDNPVYLKTTEEDLSIDIGRHSASVGHTYPAISVVSTDDDLA 845
           G +L+W+NW+ KN+ S+NFDNPVY KTTE+++ I   +     G++YP+  +VS +DD+A
Sbjct: 805 GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQD----GYSYPSRQMVSLEDDVA 860



 Score = 96.3 bits (238), Expect = 1e-19
 Identities = 49/137 (35%), Positives = 66/137 (48%), Gaps = 4/137 (2%)

Query: 28  GRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS 87
           G  + C   +F C +G CI   W+CDG  DC D SDE+NC   TC   +F C++G C+  
Sbjct: 192 GDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHG 251

Query: 88  RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE- 146
             +CD + DC+D SDE    C   T          HS +CI +   C+   DC    DE 
Sbjct: 252 SRQCDREYDCKDMSDE--VGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEP 309

Query: 147 -ENCGNITCSPDEFTCS 162
            + CG   C  +   CS
Sbjct: 310 IKECGTNECLDNNGGCS 326


>gi|61744471 low density lipoprotein receptor-related protein 8
           isoform 1 precursor [Homo sapiens]
          Length = 963

 Score =  832 bits (2150), Expect = 0.0
 Identities = 387/778 (49%), Positives = 511/778 (65%), Gaps = 63/778 (8%)

Query: 5   ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
           AL  L LLL L      + A       G G    CE  QFQC N RCI  +W+CD D+DC
Sbjct: 13  ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72

Query: 59  VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
           +D SDE +C KKTCA+SDF C+NG C+  RWKCDG+ +C DGSDES   C  + C   ++
Sbjct: 73  LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132

Query: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDD 178
           SCG  S +C+P SWRCDGE DC+ G DE  C  + C+P EF C +  C++  FVC+G DD
Sbjct: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDD 191

Query: 179 CSDGSDELDCAPPTCGAHEFQC---STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235
           C DGSDE  CA P CG  EF+C      +CIP  WVCD   DC D+SDE+ E CGR    
Sbjct: 192 CGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251

Query: 236 HTKCP-----ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC 290
            T  P     AS+  C SGEC+H  WRCDGD DCKD SDE +CP  TCR D+F+C DG+C
Sbjct: 252 ATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311

Query: 291 IHGSRQCNGIRDCVDGSDEVNC-KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSD 349
           +   + CN  +DC DGSDE  C + +N+CL                              
Sbjct: 312 VLAIKHCNQEQDCPDGSDEAGCLQGLNECLH----------------------------- 342

Query: 350 EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQI 409
                        NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P  CSQI
Sbjct: 343 -------------NNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQI 389

Query: 410 CINLKGGYKCECSRGYQMDLATGVCK-AVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL 468
           C+N KG +KCEC  GY+MDL T  CK A GK PSLIFTNR ++R+I L ++ Y +L+  L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 449

Query: 469 RNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYK 525
           +N VALD ++A  +++W DLS + I+SA +D   D   + V + + +++P  +AVDWV+K
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509

Query: 526 TIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAG 585
            IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569

Query: 586 MNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645
           +NG DR+ LV+ +I+WPNGITLDL+  RLYW+DSKLH LSS+D +G +R+ ++ S +FL+
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 629

Query: 646 HPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW 705
           HP  + +FED+V+W D ENEA++ AN+  G E++ L  NLN+  DI+++HEL QP   + 
Sbjct: 630 HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 689

Query: 706 CEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVS 762
           CE  ++ NGGCEYLCLPAPQI+ HSPKYTC+CP    +  + + C R   +T+ + ++
Sbjct: 690 CELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLA 747



 Score =  701 bits (1810), Expect = 0.0
 Identities = 371/863 (42%), Positives = 506/863 (58%), Gaps = 113/863 (13%)

Query: 70  KTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIP 129
           K C +  F C N +C+PS W+CD D DC D SDE  + C  +TC   + +C   +  CI 
Sbjct: 45  KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDCPKKTCADSDFTCD--NGHCIH 100

Query: 130 VSWRCDGENDCDSGEDEEN--CGNITCSPDEFTC--SSGRCISRNFVCNGQDDCSDGSDE 185
             W+CDGE +C  G DE    C    C  ++ +C  +S +C+  ++ C+G+ DC  G+DE
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160

Query: 186 LDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQ 245
             CA   C  HEFQC   SC+   +VCD D DC D SDE       +      C   E +
Sbjct: 161 AGCAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE-------RGCADPACGPREFR 212

Query: 246 CGS---GECIHKKWRCDGDPDCKDGSDEV------------NCPSRTCRPDQFECEDGSC 290
           CG    G CI ++W CD   DC+D SDE             + P+      QF C  G C
Sbjct: 213 CGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272

Query: 291 IHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
           +H   +C+G RDC D SDE +C  +  C G  +F+C  G C+   K CNQEQDC D SDE
Sbjct: 273 VHLGWRCDGDRDCKDKSDEADCP-LGTCRGD-EFQCGDGTCVLAIKHCNQEQDCPDGSDE 330

Query: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQIC 410
                 +NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P  CSQIC
Sbjct: 331 AGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390

Query: 411 INLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLR 469
           +N KG +KCEC  GY+MDL T  CKA  GK PSLIFTNR ++R+I L ++ Y +L+  L+
Sbjct: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450

Query: 470 NTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKT 526
           N VALD ++A  +++W DLS + I+SA +D   D   + V + + +++P  +AVDWV+K 
Sbjct: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510

Query: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586
           IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+
Sbjct: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570

Query: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
           NG DR+ LV+ +I+WPNGITLDL+  RLYW+DSKLH LSS+D +G +R+ ++ S +FL+H
Sbjct: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630

Query: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHEL--------- 697
           P  + +FED+V+W D ENEA++ AN+  G E++ L  NLN+  DI+++HEL         
Sbjct: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690

Query: 698 ---VQPSG-------------------KNWCEEDMENGGCEYLCLPAPQINDHSP---KY 732
              VQP+G                      C + M  G     C  APQ    +      
Sbjct: 691 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTM 750

Query: 733 TCSCPS-----GYNVEEN---GRDCQRINVTTAV-SEVSVP------PKGTSAAWA---- 773
           T + P+     G  V  +       +  ++T AV S VSVP      P   S A +    
Sbjct: 751 TRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQ 810

Query: 774 --------------------ILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTT 813
                               I+P++++ +  + GYL+WRNW+ KN KSMNFDNPVY KTT
Sbjct: 811 HYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTT 870

Query: 814 EE--DLSIDIGRHSASVGHTYPA 834
           EE  +  + IGR +A +GH YPA
Sbjct: 871 EEEDEDELHIGR-TAQIGHVYPA 892


>gi|65301119 low density lipoprotein receptor-related protein 8
           isoform 4 precursor [Homo sapiens]
          Length = 904

 Score =  832 bits (2150), Expect = 0.0
 Identities = 387/778 (49%), Positives = 511/778 (65%), Gaps = 63/778 (8%)

Query: 5   ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
           AL  L LLL L      + A       G G    CE  QFQC N RCI  +W+CD D+DC
Sbjct: 13  ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72

Query: 59  VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
           +D SDE +C KKTCA+SDF C+NG C+  RWKCDG+ +C DGSDES   C  + C   ++
Sbjct: 73  LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132

Query: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDD 178
           SCG  S +C+P SWRCDGE DC+ G DE  C  + C+P EF C +  C++  FVC+G DD
Sbjct: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATL-CAPHEFQCGNRSCLAAVFVCDGDDD 191

Query: 179 CSDGSDELDCAPPTCGAHEFQC---STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235
           C DGSDE  CA P CG  EF+C      +CIP  WVCD   DC D+SDE+ E CGR    
Sbjct: 192 CGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPG 251

Query: 236 HTKCP-----ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC 290
            T  P     AS+  C SGEC+H  WRCDGD DCKD SDE +CP  TCR D+F+C DG+C
Sbjct: 252 ATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTC 311

Query: 291 IHGSRQCNGIRDCVDGSDEVNC-KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSD 349
           +   + CN  +DC DGSDE  C + +N+CL                              
Sbjct: 312 VLAIKHCNQEQDCPDGSDEAGCLQGLNECLH----------------------------- 342

Query: 350 EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQI 409
                        NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P  CSQI
Sbjct: 343 -------------NNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQI 389

Query: 410 CINLKGGYKCECSRGYQMDLATGVCK-AVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL 468
           C+N KG +KCEC  GY+MDL T  CK A GK PSLIFTNR ++R+I L ++ Y +L+  L
Sbjct: 390 CVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPML 449

Query: 469 RNTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYK 525
           +N VALD ++A  +++W DLS + I+SA +D   D   + V + + +++P  +AVDWV+K
Sbjct: 450 KNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHK 509

Query: 526 TIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAG 585
            IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G
Sbjct: 510 HIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSG 569

Query: 586 MNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645
           +NG DR+ LV+ +I+WPNGITLDL+  RLYW+DSKLH LSS+D +G +R+ ++ S +FL+
Sbjct: 570 LNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLS 629

Query: 646 HPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW 705
           HP  + +FED+V+W D ENEA++ AN+  G E++ L  NLN+  DI+++HEL QP   + 
Sbjct: 630 HPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDA 689

Query: 706 CEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVS 762
           CE  ++ NGGCEYLCLPAPQI+ HSPKYTC+CP    +  + + C R   +T+ + ++
Sbjct: 690 CELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLA 747



 Score =  706 bits (1823), Expect = 0.0
 Identities = 374/872 (42%), Positives = 511/872 (58%), Gaps = 113/872 (12%)

Query: 70  KTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIP 129
           K C +  F C N +C+PS W+CD D DC D SDE  + C  +TC   + +C   +  CI 
Sbjct: 45  KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDCPKKTCADSDFTCD--NGHCIH 100

Query: 130 VSWRCDGENDCDSGEDEEN--CGNITCSPDEFTC--SSGRCISRNFVCNGQDDCSDGSDE 185
             W+CDGE +C  G DE    C    C  ++ +C  +S +C+  ++ C+G+ DC  G+DE
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160

Query: 186 LDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQ 245
             CA   C  HEFQC   SC+   +VCD D DC D SDE       +      C   E +
Sbjct: 161 AGCAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDE-------RGCADPACGPREFR 212

Query: 246 CGS---GECIHKKWRCDGDPDCKDGSDEV------------NCPSRTCRPDQFECEDGSC 290
           CG    G CI ++W CD   DC+D SDE             + P+      QF C  G C
Sbjct: 213 CGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRSGEC 272

Query: 291 IHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
           +H   +C+G RDC D SDE +C  +  C G  +F+C  G C+   K CNQEQDC D SDE
Sbjct: 273 VHLGWRCDGDRDCKDKSDEADCP-LGTCRGD-EFQCGDGTCVLAIKHCNQEQDCPDGSDE 330

Query: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQIC 410
                 +NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P  CSQIC
Sbjct: 331 AGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQIC 390

Query: 411 INLKGGYKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLR 469
           +N KG +KCEC  GY+MDL T  CKA  GK PSLIFTNR ++R+I L ++ Y +L+  L+
Sbjct: 391 VNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLK 450

Query: 470 NTVALDADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKT 526
           N VALD ++A  +++W DLS + I+SA +D   D   + V + + +++P  +AVDWV+K 
Sbjct: 451 NVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKH 510

Query: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586
           IYWTD+ +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+
Sbjct: 511 IYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGL 570

Query: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
           NG DR+ LV+ +I+WPNGITLDL+  RLYW+DSKLH LSS+D +G +R+ ++ S +FL+H
Sbjct: 571 NGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSH 630

Query: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHEL--------- 697
           P  + +FED+V+W D ENEA++ AN+  G E++ L  NLN+  DI+++HEL         
Sbjct: 631 PFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDAC 690

Query: 698 ---VQPSG-------------------KNWCEEDMENGGCEYLCLPAPQINDHSP---KY 732
              VQP+G                      C + M  G     C  APQ    +      
Sbjct: 691 ELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTM 750

Query: 733 TCSCPS-----GYNVEEN---GRDCQRINVTTAV-SEVSVP------PKGTSAAWA---- 773
           T + P+     G  V  +       +  ++T AV S VSVP      P   S A +    
Sbjct: 751 TRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPSTLSPATSNHSQ 810

Query: 774 --------------------ILPLLLLVMAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTT 813
                               I+P++++ +  + GYL+WRNW+ KN KSMNFDNPVY KTT
Sbjct: 811 HYANEDSKMGSTVTAAVIGIIVPIVVIALLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTT 870

Query: 814 EE--DLSIDIGRHSASVGHTYPAISVVSTDDD 843
           EE  +  + IGR +A +GH YPA   +S +DD
Sbjct: 871 EEEDEDELHIGR-TAQIGHVYPARVALSLEDD 901


>gi|61744467 low density lipoprotein receptor-related protein 8
           isoform 3 precursor [Homo sapiens]
          Length = 700

 Score =  696 bits (1795), Expect = 0.0
 Identities = 331/664 (49%), Positives = 455/664 (68%), Gaps = 26/664 (3%)

Query: 193 CGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECI 252
           C   +FQC    CIP  W CD+D DC D SDE  + C ++      C  S+  C +G CI
Sbjct: 47  CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDE--DDCPKKT-----CADSDFTCDNGHCI 99

Query: 253 HKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFECEDGS--CIHGSRQCNGIRDCVDGSD 308
           H++W+CDG+ +C DGSDE    C  + C  ++  C   S  C+  S +C+G +DC  G+D
Sbjct: 100 HERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD 159

Query: 309 EVNCK-NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGC 367
           E  C  ++  C G  +F+C  G C+   K CNQEQDC D SDE      +NECL NNGGC
Sbjct: 160 EAGCATSLGTCRGD-EFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGC 218

Query: 368 SHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQM 427
           SHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P  CSQIC+N KG +KCEC  GY+M
Sbjct: 219 SHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEM 278

Query: 428 DLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWA 486
           DL T  CKA  GK PSLIFTNR ++R+I L ++ Y +L+  L+N VALD ++A  +++W 
Sbjct: 279 DLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWC 338

Query: 487 DLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLD 543
           DLS + I+SA +D   D   + V + + +++P  +AVDWV+K IYWTD+ +KTISVAT+D
Sbjct: 339 DLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVD 398

Query: 544 GTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPN 603
           G +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+NG DR+ LV+ +I+WPN
Sbjct: 399 GGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPN 458

Query: 604 GITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGE 663
           GITLDL+  RLYW+DSKLH LSS+D +G +R+ ++ S +FL+HP  + +FED+V+W D E
Sbjct: 459 GITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLE 518

Query: 664 NEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDME-NGGCEYLCLPA 722
           NEA++ AN+  G E++ L  NLN+  DI+++HEL QP   + CE  ++ NGGCEYLCLPA
Sbjct: 519 NEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPA 578

Query: 723 PQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVSVPPKGTSAAWAIL-PLLLLV 781
           PQI+ HSPKYTC+CP    +  + + C R     A  +  +    T+A   I+ P++++ 
Sbjct: 579 PQISSHSPKYTCACPDTMWLGPDMKRCYR----DANEDSKMGSTVTAAVIGIIVPIVVIA 634

Query: 782 MAAVGGYLMWRNWQHKNMKSMNFDNPVYLKTTEE--DLSIDIGRHSASVGHTYPAISVVS 839
           +  + GYL+WRNW+ KN KSMNFDNPVY KTTEE  +  + IGR +A +GH YPA   +S
Sbjct: 635 LLCMSGYLIWRNWKRKNTKSMNFDNPVYRKTTEEEDEDELHIGR-TAQIGHVYPARVALS 693

Query: 840 TDDD 843
            +DD
Sbjct: 694 LEDD 697



 Score =  209 bits (533), Expect = 7e-54
 Identities = 101/218 (46%), Positives = 123/218 (56%), Gaps = 14/218 (6%)

Query: 5   ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
           AL  L LLL L      + A       G G    CE  QFQC N RCI  +W+CD D+DC
Sbjct: 13  ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72

Query: 59  VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
           +D SDE +C KKTCA+SDF C+NG C+  RWKCDG+ +C DGSDES   C  + C   ++
Sbjct: 73  LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132

Query: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNI--TCSPDEFTCSSGRCISRNFVCNGQ 176
           SCG  S +C+P SWRCDGE DC+ G DE  C     TC  DEF C  G C+     CN +
Sbjct: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDGTCVLAIKHCNQE 192

Query: 177 DDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDD 214
            DC DGSDE  C     G +E   +   C   S +C D
Sbjct: 193 QDCPDGSDEAGCLQ---GLNECLHNNGGC---SHICTD 224


>gi|157384998 low density lipoprotein receptor-related protein 4
           [Homo sapiens]
          Length = 1905

 Score =  602 bits (1553), Expect = e-172
 Identities = 312/754 (41%), Positives = 419/754 (55%), Gaps = 50/754 (6%)

Query: 7   WALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGR-----CITLLWKCDGDEDCVDG 61
           W   LL AL  A        +  +  C  S F C         CI   W+CDGD DC D 
Sbjct: 5   WGALLLGALLCAH----GLASSPECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDH 60

Query: 62  SDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCG 121
           SDE  C+  TC+  DF C+NG+C+   W CDGD DCED SDE  + C  R C   E  C 
Sbjct: 61  SDEDGCILPTCSPLDFHCDNGKCIRRSWVCDGDNDCEDDSDE--QDCPPRECEEDEFPC- 117

Query: 122 AHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSD 181
             +  CI   W CDG+NDC    DE+ C    CS  EF CS G CI+ ++ C+G  DC D
Sbjct: 118 -QNGYCIRSLWHCDGDNDCGDNSDEQ-CDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKD 175

Query: 182 GSDELDC-----APPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH 236
           GSDE +C     APP C   EFQC+   CI   + CD D DC D SDES   C      H
Sbjct: 176 GSDEENCPSAVPAPP-CNLEEFQCAYGRCILDIYHCDGDDDCGDWSDES--DCSS----H 228

Query: 237 TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQ 296
             C + E  C SG CI+  WRCDGD DC D SDE NC +  C  +QF C  G C+  S +
Sbjct: 229 QPCRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAEQFRCHSGRCVRLSWR 288

Query: 297 CNGIRDCVDGSDEVNCKNVN--QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE-PLK 353
           C+G  DC D SDE NC+N    QC    +F C +G CI   K+CN   DC D SDE P +
Sbjct: 289 CDGEDDCADNSDEENCENTGSPQC-ALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQ 347

Query: 354 ECHIN----ECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQ 408
            C        C VNNGGC+  C+ +    +C C  G+ L  D  TC D++EC   G CSQ
Sbjct: 348 NCRPRTGEENCNVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNECAEEGYCSQ 407

Query: 409 ICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQL 468
            C N +G ++C C  GY++      CKA+G EP L+F NR DIR++   R EY  L+  L
Sbjct: 408 GCTNSEGAFQCWCETGYELRPDRRSCKALGPEPVLLFANRIDIRQVLPHRSEYTLLLNNL 467

Query: 469 RNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI--DNVYNPAAIAVDWVYKT 526
            N +ALD     + +FW+D++   I  A+++   G +V+ +    + +P  +AVDWV+  
Sbjct: 468 ENAIALDFHHRRELVFWSDVTLDRILRANLN---GSNVEEVVSTGLESPGGLAVDWVHDK 524

Query: 527 IYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGM 586
           +YWTD+ +  I VA LDG  RK L   +L +P +IA+ P+ G +YW+DWG   +IE + M
Sbjct: 525 LYWTDSGTSRIEVANLDGAHRKVLLWQNLEKPRAIALHPMEGTIYWTDWGNTPRIEASSM 584

Query: 587 NGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
           +G  RR +    + WPNG+T+D    R+YW+D+K H++   +L+G  R+ V+   + L H
Sbjct: 585 DGSGRRIIADTHLFWPNGLTIDYAGRRMYWVDAKHHVIERANLDGSHRKAVIS--QGLPH 642

Query: 647 PLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWC 706
           P A+T+FED +YW D   +++  ANKFTG     + N L+   DI   H   QP+GKN C
Sbjct: 643 PFAITVFEDSLYWTDWHTKSINSANKFTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRC 702

Query: 707 EEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
            ++  NGGC +LCLP+ Q       YTC+CP+G+
Sbjct: 703 GDN--NGGCTHLCLPSGQ------NYTCACPTGF 728



 Score =  239 bits (609), Expect = 1e-62
 Identities = 125/362 (34%), Positives = 203/362 (56%), Gaps = 20/362 (5%)

Query: 391  RKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD 450
            +  CGD     N G C+ +C+     Y C C  G++  +++  C A   +  L+F  R D
Sbjct: 699  KNRCGD-----NNGGCTHLCLPSGQNYTCACPTGFRK-ISSHAC-AQSLDKFLLFARRMD 751

Query: 451  IRKIGLERKEYIQLVEQL---RNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK 507
            IR+I  + ++    V  L   R+ VALD D     ++W D+S   I  A  D   G+ V 
Sbjct: 752  IRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRAKWDG-TGQEVV 810

Query: 508  MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLS 567
            +  ++ +PA +A+DWV   +YWTDA +  I VA  DG+ R  L   +L  P  I V+P+ 
Sbjct: 811  VDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWENLDRPRDIVVEPMG 870

Query: 568  GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
            G++YW+DWG   KIE+AGM+   R+ ++++++ WPNG+ +D    RLYW D+ +  +   
Sbjct: 871  GYMYWTDWGASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRLYWADAGMKTIEFA 930

Query: 628  DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
             L+G  R++++ S   L HP  LT++ +R+YW D + +++  A++ TG +  TL  NL +
Sbjct: 931  GLDGSKRKVLIGSQ--LPHPFGLTLYGERIYWTDWQTKSIQSADRLTGLDRETLQENLEN 988

Query: 688  AQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR 747
              DI V+H   +P     C   MENGGC +LCL +P    +   ++C+CP+G N+  +G+
Sbjct: 989  LMDIHVFHRR-RPPVSTPCA--MENGGCSHLCLRSP----NPSGFSCTCPTGINLLSDGK 1041

Query: 748  DC 749
             C
Sbjct: 1042 TC 1043



 Score =  223 bits (568), Expect = 6e-58
 Identities = 144/489 (29%), Positives = 243/489 (49%), Gaps = 73/489 (14%)

Query: 387  ELIDRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIF 445
            + +DR      ++C    G CS +C+    G+ C C  G Q+      C     E  L+F
Sbjct: 1300 QAVDRAQPLGFNKCGSRNGGCSHLCLPRPSGFSCACPTGIQLKGDGKTCDP-SPETYLLF 1358

Query: 446  TNRRDIRKIGLERKEYIQL---VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDK- 501
            ++R  IR+I L+  ++  +   V +L N ++LD D    K+++ D+    I  A ++   
Sbjct: 1359 SSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGKVYYTDVFLDVIRRADLNGSN 1418

Query: 502  ----VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLRE 557
                +GR +K  D       +AVDWV + +YWTD    TI  + LDG+ RK L N+ L E
Sbjct: 1419 METVIGRGLKTTDG------LAVDWVARNLYWTDTGRNTIEASRLDGSCRKVLINNSLDE 1472

Query: 558  PASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWL 617
            P +IAV P  G+++W+DWG  AKIE+A ++G +R+ L+  D+ WPNG+TLD    R+YW+
Sbjct: 1473 PRAIAVFPRKGYLFWTDWGHIAKIERANLDGSERKVLINTDLGWPNGLTLDYDTRRIYWV 1532

Query: 618  DSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSE 677
            D+ L  + S DLNG+ R+++   +  ++HP ALT  +  +YW D + +++   +K++G  
Sbjct: 1533 DAHLDRIESADLNGKLRQVL---VSHVSHPFALTQQDRWIYWTDWQTKSIQRVDKYSGRN 1589

Query: 678  LATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCL----------------- 720
              T++ N+    DIIV     Q +G N C   + NGGC +LC                  
Sbjct: 1590 KETVLANVEGLMDIIVVSPQRQ-TGTNAC--GVNNGGCTHLCFARASDFVCACPDEPDSR 1646

Query: 721  ----------PAPQINDHSPK------------YTCSCPSGYNVEENGRDCQ----RINV 754
                      PAP+    S K            Y+ +  +  ++EE    C     R+ +
Sbjct: 1647 PCSLVPGLVPPAPRATGMSEKSPVLPNTPPTTLYSSTTRTRTSLEEVEGRCSERDARLGL 1706

Query: 755  TTAVSEV--SVPPKGTSAAWAILPLL--LLVMAAVGGYLMWRNWQHK----NMKSMNFDN 806
                ++   + P +G   ++AI  LL  LL++  +   +++R+ + K     M ++ + N
Sbjct: 1707 CARSNDAVPAAPGEGLHISYAIGGLLSILLILVVIAALMLYRHKKSKFTDPGMGNLTYSN 1766

Query: 807  PVYLKTTEE 815
            P Y  +T+E
Sbjct: 1767 PSYRTSTQE 1775



 Score =  214 bits (546), Expect = 2e-55
 Identities = 124/397 (31%), Positives = 198/397 (49%), Gaps = 61/397 (15%)

Query: 360  CLVNNGGCSHIC--KDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
            C + NGGCSH+C       G+ C C  G  L+ D KTC       +PG+ S         
Sbjct: 1006 CAMENGGCSHLCLRSPNPSGFSCTCPTGINLLSDGKTC-------SPGMNS--------- 1049

Query: 417  YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVE----QLRNTV 472
                                      LIF  R DIR + L+   +  +V      ++NT+
Sbjct: 1050 -------------------------FLIFARRIDIRMVSLDIPYFADVVVPINITMKNTI 1084

Query: 473  ALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
            A+  D    K++W+D +   I  A++D      + +   +     +AVD + + +YWTD 
Sbjct: 1085 AIGVDPQEGKVYWSDSTLHRISRANLDGSQHEDI-ITTGLQTTDGLAVDAIGRKVYWTDT 1143

Query: 533  ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
             +  I V  LDG+ RK L   +L  P +I +    GF+YW+DWGE AK+E++GM+G DR 
Sbjct: 1144 GTNRIEVGNLDGSMRKVLVWQNLDSPRAIVLYHEMGFMYWTDWGENAKLERSGMDGSDRA 1203

Query: 593  PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652
             L+  ++ WPNG+T+D   S+L W D+    + + DLNG +R  ++  ++   HP  LT+
Sbjct: 1204 VLINNNLGWPNGLTVDKASSQLLWADAHTERIEAADLNGANRHTLVSPVQ---HPYGLTL 1260

Query: 653  FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMEN 712
             +  +YW D +  +++ A+K TGS +  + +NL    D+    +  QP G N C     N
Sbjct: 1261 LDSYIYWTDWQTRSIHRADKGTGSNVILVRSNLPGLMDMQAV-DRAQPLGFNKC--GSRN 1317

Query: 713  GGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
            GGC +LCLP P        ++C+CP+G  ++ +G+ C
Sbjct: 1318 GGCSHLCLPRPS------GFSCACPTGIQLKGDGKTC 1348



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 13/32 (40%), Positives = 18/32 (56%)

Query: 351  PLKECHINECLVNNGGCSHICKDLVIGYECDC 382
            P ++   N C VNNGGC+H+C      + C C
Sbjct: 1608 PQRQTGTNACGVNNGGCTHLCFARASDFVCAC 1639



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 21/77 (27%), Positives = 32/77 (41%), Gaps = 8/77 (10%)

Query: 677 ELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
           +L   VN+  D  D          +G+  C  ++ NGGC   C              C+C
Sbjct: 329 KLCNGVNDCGDNSDESPQQNCRPRTGEENC--NVNNGGCAQKCQMV------RGAVQCTC 380

Query: 737 PSGYNVEENGRDCQRIN 753
            +GY + E+G  CQ +N
Sbjct: 381 HTGYRLTEDGHTCQDVN 397


>gi|66082554 low density lipoprotein receptor-related protein 8
           isoform 2 precursor [Homo sapiens]
          Length = 793

 Score =  592 bits (1525), Expect = e-169
 Identities = 270/531 (50%), Positives = 370/531 (69%), Gaps = 7/531 (1%)

Query: 239 CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCN 298
           C   + QC +  CI   WRCD D DC D SDE +CP +TC    F C++G CIH   +C+
Sbjct: 47  CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCD 106

Query: 299 GIRDCVDGSDEVNCKNVNQCLGPGKFKC--RSGECIDISKVCNQEQDCRDWSDEPLKECH 356
           G  +C DGSDE       Q     K  C   S +C+  S  C+ E+DC   +DE      
Sbjct: 107 GEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATW 166

Query: 357 INECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGG 416
           +NECL NNGGCSHIC DL IG+EC C AGF+L+D+KTCGDIDEC++P  CSQIC+N KG 
Sbjct: 167 LNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGY 226

Query: 417 YKCECSRGYQMDLATGVCKAV-GKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALD 475
           +KCEC  GY+MDL T  CKA  GK PSLIFTNR ++R+I L ++ Y +L+  L+N VALD
Sbjct: 227 FKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALD 286

Query: 476 ADIAAQKLFWADLSQKAIFSASID---DKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDA 532
            ++A  +++W DLS + I+SA +D   D   + V + + +++P  +AVDWV+K IYWTD+
Sbjct: 287 VEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDS 346

Query: 533 ASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRR 592
            +KTISVAT+DG +R+ LF+ +L EP +IAVDPL GF+YWSDWG+ AKIEK+G+NG DR+
Sbjct: 347 GNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQ 406

Query: 593 PLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTI 652
            LV+ +I+WPNGITLDL+  RLYW+DSKLH LSS+D +G +R+ ++ S +FL+HP  + +
Sbjct: 407 TLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAV 466

Query: 653 FEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDME- 711
           FED+V+W D ENEA++ AN+  G E++ L  NLN+  DI+++HEL QP   + CE  ++ 
Sbjct: 467 FEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQP 526

Query: 712 NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRINVTTAVSEVS 762
           NGGCEYLCLPAPQI+ HSPKYTC+CP    +  + + C R   +T+ + ++
Sbjct: 527 NGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLA 577



 Score =  177 bits (450), Expect = 3e-44
 Identities = 88/200 (44%), Positives = 108/200 (54%), Gaps = 23/200 (11%)

Query: 5   ALWALWLLLALCWAPRESGAT------GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDC 58
           AL  L LLL L      + A       G G    CE  QFQC N RCI  +W+CD D+DC
Sbjct: 13  ALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDC 72

Query: 59  VDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEI 118
           +D SDE +C KKTCA+SDF C+NG C+  RWKCDG+ +C DGSDES   C  + C   ++
Sbjct: 73  LDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKL 132

Query: 119 SCGAHSTQCIPVSWRCDGENDCDSGEDEENC---------GNITCS--------PDEFTC 161
           SCG  S +C+P SWRCDGE DC+ G DE  C          N  CS          E TC
Sbjct: 133 SCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHICTDLKIGFECTC 192

Query: 162 SSGRCISRNFVCNGQDDCSD 181
            +G  +     C   D+C D
Sbjct: 193 PAGFQLLDQKTCGDIDECKD 212



 Score =  109 bits (272), Expect = 1e-23
 Identities = 65/210 (30%), Positives = 94/210 (44%), Gaps = 31/210 (14%)

Query: 111 RTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRN 170
           + C   +  C   + +CIP  WRCD ++DC    DE++C   TC+  +FTC +G CI   
Sbjct: 45  KDCEKDQFQC--RNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIHER 102

Query: 171 FVCNGQDDCSDGSDELD--CAPPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESL 226
           + C+G+++C DGSDE +  C    C A +  C  +S  C+P SW CD + DC   +DE+ 
Sbjct: 103 WKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEA- 161

Query: 227 EQCGRQPVIHTKCPASEIQCGS--GECIHKKWRCDG-DPDCKDGSDEVNCPSRTCRPDQF 283
                              C +   EC+H    C     D K G  E  CP+     DQ 
Sbjct: 162 ------------------GCATWLNECLHNNGGCSHICTDLKIGF-ECTCPAGFQLLDQK 202

Query: 284 ECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
            C D         C+ I  CV+      C+
Sbjct: 203 TCGDIDECKDPDACSQI--CVNYKGYFKCE 230


>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
          Length = 4544

 Score =  540 bits (1390), Expect = e-153
 Identities = 301/783 (38%), Positives = 424/783 (54%), Gaps = 82/783 (10%)

Query: 32   KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKC 91
            +C+ +  QC+NGRC++ +  C+G +DC DGSDE  C K  C   +F C +G C+ +  +C
Sbjct: 2565 RCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRC 2624

Query: 92   DGDPDCEDGSDE---SPEQCHM---------------RTCRIHEIS--------CGAHST 125
            +   DCED SDE   S   C                 RT   +  S        CG +S 
Sbjct: 2625 NQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSD 2684

Query: 126  Q----------------------CIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSS 163
            +                      CIP+SW CD E+DC+ GEDE +C N  CS  +F C +
Sbjct: 2685 ERDCPGVKRPRCPLNYFACPSGRCIPMSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQN 2743

Query: 164  GRCISRNFVCNGQDDCSDGSDEL-DCAPPTCGAHEFQC-STSSCIPISWVCDDDADCSDQ 221
             RCIS+ ++C+G DDC DGSDE   C   TCG   F C  T  C+P  W+CD D DC+D 
Sbjct: 2744 HRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADG 2803

Query: 222  SDESLEQ-CGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV-NCPSRTCR 279
            +DES+   C    + ++ C   E  C + +CI K + CD D DC DGSDE   C   TC 
Sbjct: 2804 ADESIAAGC----LYNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCG 2859

Query: 280  PDQFECEDGSCIHGSR-QCNGIRDCVDGSDEV----NCKNV-NQCLGPGKFKCRSGECID 333
            P +F C +G C+   + +C+G  DC D SDE     +C +  ++C    +F C SG C+ 
Sbjct: 2860 PSEFRCANGRCLSSRQWECDGENDCHDQSDEAPKNPHCTSQEHKCNASSQFLCSSGRCVA 2919

Query: 334  ISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHICKDLVIGYECDCAAGFELIDR- 391
             + +CN + DC D SDE  + CHINECL     GCS  C+DL IG++C C  GF L D  
Sbjct: 2920 EALLCNGQDDCGDSSDE--RGCHINECLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDG 2977

Query: 392  KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATG-VCKAV-GKEPSLIFTNRR 449
            +TC D+DEC     CSQ CIN  G YKC C  GY         CKAV  +EP LIF NR 
Sbjct: 2978 RTCADVDECSTTFPCSQRCINTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRY 3037

Query: 450  DIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI 509
             +RK+ L+   Y  L + L N VALD D   Q ++W D++ +      +    G +V+++
Sbjct: 3038 YLRKLNLDGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLN-GSNVQVL 3096

Query: 510  DN--VYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLS 567
                + NP  +AVDWV   +YW D    TI V+ L+G  R  L +S LREP ++ VD  +
Sbjct: 3097 HRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYRTVLVSSGLREPRALVVDVQN 3156

Query: 568  GFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
            G++YW+DWG+ + I + GM+G  R  +V   I WPNG+TLD +  R+YW D++   +   
Sbjct: 3157 GYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWADAREDYIEFA 3216

Query: 628  DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
             L+G +R +VL   + + H  ALT+FED VYW D E +++  A+K TG+    L++ L+ 
Sbjct: 3217 SLDGSNRHVVLS--QDIPHIFALTLFEDYVYWTDWETKSINRAHKTTGTNKTLLISTLHR 3274

Query: 688  AQDIIVYHELVQPSGKNW-CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENG 746
              D+ V+H L QP   N  C+  + NGGC  LCL +P        + C+CP+ + +  +G
Sbjct: 3275 PMDLHVFHALRQPDVPNHPCK--VNNGGCSNLCLLSP-----GGGHKCACPTNFYLGSDG 3327

Query: 747  RDC 749
            R C
Sbjct: 3328 RTC 3330



 Score =  538 bits (1386), Expect = e-153
 Identities = 292/748 (39%), Positives = 410/748 (54%), Gaps = 59/748 (7%)

Query: 33   CEPSQFQCT-NGRCITLLWKCDGDEDCVDGSDEK-NCVKKTCAESDFVC-NNGQCVPSRW 89
            C P+QFQC+   RCI  +W CD D DCVDGSDE  NC + TC   +F C ++G+C+P+RW
Sbjct: 3453 CAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARW 3512

Query: 90   KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
            KCDG+ DC DGSDE  E+C  RTC  ++  C   + +C+P  W+CD +NDC    DEE+C
Sbjct: 3513 KCDGEDDCGDGSDEPKEECDERTCEPYQFRC--KNNRCVPGRWQCDYDNDCGDNSDEESC 3570

Query: 150  GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPIS 209
                CS  EF+C++GRCI+  + C+G  DC+DGSDE DC P  C   +FQC +  CIP+ 
Sbjct: 3571 TPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDCTP-RCDMDQFQCKSGHCIPLR 3629

Query: 210  WVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSD 269
            W CD DADC D SDE  E CG    + T CP  E QC +  C    W+CDG+ DC D SD
Sbjct: 3630 WRCDADADCMDGSDE--EACGTG--VRT-CPLDEFQCNNTLCKPLAWKCDGEDDCGDNSD 3684

Query: 270  E--VNCPSRTCRPDQ-FECE-DGSCIHGSRQCNGIRDCVDGSDEVNCK----NVNQCLGP 321
            E    C    C P++ F C+ D  C+   RQC+G  +C DG+DE +C+    +   C   
Sbjct: 3685 ENPEECARFVCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDK 3744

Query: 322  GKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYE-- 379
             +F CR+  C+  S  CN   DC D SDE  ++C I+  L +    + IC D        
Sbjct: 3745 KEFLCRNQRCLSSSLRCNMFDDCGDGSDE--EDCSIDPKLTSCATNASICGDEARCVRTE 3802

Query: 380  ----CDCAAGFELIDRKT-CGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVC 434
                C C +GF  +  +  C DI+EC   G CSQ+C N KGG+ C C+R +     T  C
Sbjct: 3803 KAAYCACRSGFHTVPGQPGCQDINECLRFGTCSQLCNNTKGGHLCSCARNFMKTHNT--C 3860

Query: 435  KAVGKEPSLIF-TNRRDIRKI--GLERKEYIQLVE--QLRNTVALDADIAAQKLFWAD-- 487
            KA G E  +++  +  +IR +  G     Y Q  +  +     A+D  + A +++W +  
Sbjct: 3861 KAEGSEYQVLYIADDNEIRSLFPGHPHSAYEQAFQGDESVRIDAMDVHVKAGRVYWTNWH 3920

Query: 488  ---LSQKAIFSASIDDKVGRHVKMIDN---------VYNPAAIAVDWVYKTIYWTDAASK 535
               +S +++  A+      RH + ID          +  P  IA+DWV   +YWTD+   
Sbjct: 3921 TGTISYRSLPPAAPPTTSNRHRRQIDRGVTHLNISGLKMPRGIAIDWVAGNVYWTDSGRD 3980

Query: 536  TISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLV 595
             I VA + G  RK L +  + EP +I VDPL G +YWSDWG   KIE A M+G  R  LV
Sbjct: 3981 VIEVAQMKGENRKTLISGMIDEPHAIVVDPLRGTMYWSDWGNHPKIETAAMDGTLRETLV 4040

Query: 596  TADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFED 655
              +IQWP G+ +D    RLYW D+KL ++ S+ LNG D  +   S   L+HP ++ +FED
Sbjct: 4041 QDNIQWPTGLAVDYHNERLYWADAKLSVIGSIRLNGTDPIVAADSKRGLSHPFSIDVFED 4100

Query: 656  RVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGC 715
             +Y +   N  V+  +KF  S L  L   L+ A D+++YH+  QP   N C+       C
Sbjct: 4101 YIYGVTYINNRVFKIHKFGHSPLVNLTGGLSHASDVVLYHQHKQPEVTNPCDRKK----C 4156

Query: 716  EYLCLPAPQINDHSPKYTCSCPSGYNVE 743
            E+LCL +P      P   C+CP+G  ++
Sbjct: 4157 EWLCLLSPS----GP--VCTCPNGKRLD 4178



 Score =  521 bits (1341), Expect = e-147
 Identities = 283/739 (38%), Positives = 397/739 (53%), Gaps = 34/739 (4%)

Query: 32   KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKN--CVKKTCAESDFVCNNGQCVPSRW 89
            +C+P +F C N RCI   WKCDGD DC+D SDE    C + TC    F C N +C+P+RW
Sbjct: 853  QCQPGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSDRFKCENNRCIPNRW 912

Query: 90   KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEE-N 148
             CDGD DC +  DES   C  RTC  ++ SC   S +CIP+SW CD ++DC    DE  +
Sbjct: 913  LCDGDNDCGNSEDESNATCSARTCPPNQFSCA--SGRCIPISWTCDLDDDCGDRSDESAS 970

Query: 149  CGNITCSP-DEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIP 207
            C   TC P  +FTC++GRCI+ N+ C+  +DC D SDE  C+  +C + +F+C++  CIP
Sbjct: 971  CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDEAGCSH-SCSSTQFKCNSGRCIP 1029

Query: 208  ISWVCDDDADCSDQSDESLEQCGRQPVIHTK-CPASEIQCG-SGECIHKKWRCDGDPDCK 265
              W CD D DC D SDE+   C  Q       C   E QC   G CI  +WRCDGD DC 
Sbjct: 1030 EHWTCDGDNDCGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCM 1089

Query: 266  DGSDEVNCPSRT--CRPD-QFECEDGS-CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 321
            D SDE +C   T  C P  +F C+D + CI  +  C+G  DC D SDE NC+++     P
Sbjct: 1090 DSSDEKSCEGVTHVCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESL--ACRP 1147

Query: 322  GKFKCRSGE--CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV-IGY 378
                C +    C+   K+C+   DC D SDE  + C  ++C +NNGGCSH C      G 
Sbjct: 1148 PSHPCANNTSVCLPPDKLCDGNDDCGDGSDEG-ELC--DQCSLNNGGCSHNCSVAPGEGI 1204

Query: 379  ECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
             C C  G EL  D  TC     C     CSQ C   K   KC C  G+ ++     C+++
Sbjct: 1205 VCSCPLGMELGPDNHTCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSL 1264

Query: 438  GK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSA 496
               +P +IF+NR +IR+I L + +Y  LV  LRNT+ALD  ++   L+W D+ +  I+  
Sbjct: 1265 DPFKPFIIFSNRHEIRRIDLHKGDYSVLVPGLRNTIALDFHLSQSALYWTDVVEDKIYRG 1324

Query: 497  SIDDK---VGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNS 553
             + D        V +   +  P  +AVDW+   IYW ++    I VA LDGT R  L   
Sbjct: 1325 KLLDNGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAG 1384

Query: 554  DLREPASIAVDPLSGFVYWSDWGEPA-KIEKAGMNGFDRRPL--VTADIQWPNGITLDLI 610
            D+  P +IA+DP  G ++W+DW     +IE A M+G  RR +   T    WPNG+T+D +
Sbjct: 1385 DIEHPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYL 1444

Query: 611  KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGA 670
            + R+ W+D++   + S   +G     VL+  EFL+HP A+T++   VYW D     +  A
Sbjct: 1445 EKRILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKA 1504

Query: 671  NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSP 730
            NK+TG  +  +        D+ VYH   QP   N CE +   G C +LCL    IN ++ 
Sbjct: 1505 NKWTGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCL----IN-YNR 1559

Query: 731  KYTCSCPSGYNVEENGRDC 749
              +C+CP    + ++   C
Sbjct: 1560 TVSCACPHLMKLHKDNTTC 1578



 Score =  302 bits (773), Expect = 1e-81
 Identities = 156/423 (36%), Positives = 228/423 (53%), Gaps = 36/423 (8%)

Query: 23   GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNN 81
            G+ G    + C  SQF C N +CI   WKCD ++DC D SDE  +C +  C    F C+ 
Sbjct: 3324 GSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCST 3383

Query: 82   GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
            G C    + CDGD DC+D SDE+   C +  C   +  C  ++ +CIP  +RC+G+++C 
Sbjct: 3384 GICTNPAFICDGDNDCQDNSDEA--NCDIHVCLPSQFKC-TNTNRCIPGIFRCNGQDNCG 3440

Query: 142  SGEDEENCGNITCSPDEFTCS-SGRCISRNFVCNGQDDCSDGSDE-LDCAPPTCGAHEFQ 199
             GEDE +C  +TC+P++F CS + RCI R +VC+  +DC DGSDE  +C   TCG  EF+
Sbjct: 3441 DGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFR 3500

Query: 200  CSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRC 258
            C  S  CIP  W CD + DC D SDE  E+C  +      C   + +C +  C+  +W+C
Sbjct: 3501 CKDSGRCIPARWKCDGEDDCGDGSDEPKEECDER-----TCEPYQFRCKNNRCVPGRWQC 3555

Query: 259  DGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQC 318
            D D DC D SDE +C  R C   +F C +G CI G  +C+G  DC DGSDE +C    +C
Sbjct: 3556 DYDNDCGDNSDEESCTPRPCSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC--TPRC 3613

Query: 319  LGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSH-ICKDLVIG 377
                +F+C+SG CI +   C+ + DC D SDE      +  C ++   C++ +CK L   
Sbjct: 3614 -DMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPL--A 3670

Query: 378  YECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
            ++CD            CGD  + +NP  C++        ++C+  R         VC  +
Sbjct: 3671 WKCD--------GEDDCGDNSD-ENPEECARFVCPPNRPFRCKNDR---------VCLWI 3712

Query: 438  GKE 440
            G++
Sbjct: 3713 GRQ 3715



 Score =  298 bits (762), Expect = 2e-80
 Identities = 160/392 (40%), Positives = 208/392 (53%), Gaps = 28/392 (7%)

Query: 32   KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVC-NNGQCVPSRWK 90
            KC P QFQC+ G C    + CDGD DC D SDE NC    C  S F C N  +C+P  ++
Sbjct: 3373 KCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVCLPSQFKCTNTNRCIPGIFR 3432

Query: 91   CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENC 149
            C+G  +C DG DE    C   TC  ++  C   + +CIP  W CD +NDC  G DE  NC
Sbjct: 3433 CNGQDNCGDGEDE--RDCPEVTCAPNQFQCSI-TKRCIPRVWVCDRDNDCVDGSDEPANC 3489

Query: 150  GNITCSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCI 206
              +TC  DEF C  SGRCI   + C+G+DDC DGSDE   +C   TC  ++F+C  + C+
Sbjct: 3490 TQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCV 3549

Query: 207  PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKD 266
            P  W CD D DC D SDE  E C  +P     C  SE  C +G CI  +W+CDGD DC D
Sbjct: 3550 PGRWQCDYDNDCGDNSDE--ESCTPRP-----CSESEFSCANGRCIAGRWKCDGDHDCAD 3602

Query: 267  GSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKC 326
            GSDE +C  R C  DQF+C+ G CI    +C+   DC+DGSDE  C    +     +F+C
Sbjct: 3603 GSDEKDCTPR-CDMDQFQCKSGHCIPLRWRCDADADCMDGSDEEACGTGVRTCPLDEFQC 3661

Query: 327  RSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNG-GCSHICKDLVIGYECDCAAG 385
             +  C  ++  C+ E DC D SDE  +EC    C  N    C +    L IG +CD    
Sbjct: 3662 NNTLCKPLAWKCDGEDDCGDNSDENPEECARFVCPPNRPFRCKNDRVCLWIGRQCD---- 3717

Query: 386  FELIDRKTCG---DIDECQNPGICSQICINLK 414
                    CG   D ++C+ P   +  C + K
Sbjct: 3718 ----GTDNCGDGTDEEDCEPPTAHTTHCKDKK 3745



 Score =  244 bits (622), Expect = 3e-64
 Identities = 158/504 (31%), Positives = 251/504 (49%), Gaps = 35/504 (6%)

Query: 276 RTCRPDQFECEDG-SCIHGSRQCNGIRDCVDGSDE---VNCKNVNQCLGPGKFKCRSGE- 330
           +TC P QF C D  +CI    +C+G RDC DGSDE   +  ++  Q   P +  C   E 
Sbjct: 25  KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTEL 84

Query: 331 CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFEL-I 389
           C+ +S++CN  QDC D SDE    C   +   +  GC H C   + G  C C + F+L  
Sbjct: 85  CVPMSRLCNGVQDCMDGSDEG-PHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQA 143

Query: 390 DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKA----VGKEPSLIF 445
           D KTC D DEC   G CSQ+C N  G + C C  GY +      CKA    V + P L+ 
Sbjct: 144 DGKTCKDFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNEPVDRPPVLLI 203

Query: 446 TNRRDIRKIGLERKEYIQLVE-QLRNTVALDADIAAQKLFWADLSQKAIFSA-------S 497
            N ++I    L   +   +     R T A+D   A + + W  +   A  +         
Sbjct: 204 ANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMPG 263

Query: 498 IDDKVGRHVKMID-NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR 556
           +   V  H   I  ++++   +A+DW+    Y+ D     I V   +G     L + +L 
Sbjct: 264 LKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELY 323

Query: 557 EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616
            P  IA+DP  G V+++D+G+  K+E+  M+G +R  LV + I +P+GITLDL+   +YW
Sbjct: 324 NPKGIALDPAMGKVFFTDYGQIPKVERCDMDGQNRTKLVDSKIVFPHGITLDLVSRLVYW 383

Query: 617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGEN------EAVYGA 670
            D+ L  +  VD  G+ R+ +++ +  + H   LT+FE+ +Y  + +N       +V   
Sbjct: 384 ADAYLDYIEVVDYEGKGRQTIIQGI-LIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV 442

Query: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNW-CEEDM--ENGGCEYLCLPAPQIND 727
           N+F  +E   +V  ++    + +YH+  QP  ++  CE D   + GGC  +CL A   N 
Sbjct: 443 NRFNSTEY-QVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLA---NS 498

Query: 728 HSPKYTCSCPSGYNVEENGRDCQR 751
           H  + TC C SG+++  +G+ C++
Sbjct: 499 HKAR-TCRCRSGFSLGSDGKSCKK 521



 Score =  216 bits (551), Expect = 5e-56
 Identities = 143/424 (33%), Positives = 194/424 (45%), Gaps = 49/424 (11%)

Query: 33   CEPSQFQCTNGRCITL-LWKCDGDEDCVDGS-----DEKNC--VKKTC-AESDFVCNNGQ 83
            CE S  +  NG C  L L    G  +C         D+  C  V  +C A+ +F C NG+
Sbjct: 2477 CELSPCRINNGGCQDLCLLTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGE 2536

Query: 84   CVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSG 143
            C+     CDG P C+D SDE P  C+ R C+     C   + +C+     C+G +DC  G
Sbjct: 2537 CINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCS--NGRCVSNMLWCNGADDCGDG 2594

Query: 144  EDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAH------- 196
             DE  C    C   EF C  G CI  +  CN   DC D SDE++C+   C ++       
Sbjct: 2595 SDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKG 2654

Query: 197  -EFQ-CS-TSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIH 253
              FQ C  TS C   SWVCD   DC D SDE    C    V   +CP +   C SG CI 
Sbjct: 2655 VLFQPCERTSLCYAPSWVCDGANDCGDYSDE--RDC--PGVKRPRCPLNYFACPSGRCIP 2710

Query: 254  KKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDE-VNC 312
              W CD + DC+ G DE +C ++ C   QFEC++  CI     C+G  DC DGSDE  +C
Sbjct: 2711 MSWTCDKEDDCEHGEDETHC-NKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHC 2769

Query: 313  KNVNQCLGPGKFKCRSGE-CIDISKVCNQEQDCRDWSDEPL-------KECHINECLVNN 364
            +   +  GP  F C     C+    +C+ ++DC D +DE +         C   E +  N
Sbjct: 2770 E--GKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMCQN 2827

Query: 365  GGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRG 424
              C  I K  V  ++ DCA G +        +  EC+ P  C         G +C  SR 
Sbjct: 2828 RQC--IPKHFVCDHDRDCADGSD--------ESPECEYP-TCGPSEFRCANG-RCLSSRQ 2875

Query: 425  YQMD 428
            ++ D
Sbjct: 2876 WECD 2879



 Score =  213 bits (541), Expect = 8e-55
 Identities = 173/611 (28%), Positives = 254/611 (41%), Gaps = 86/611 (14%)

Query: 21   ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVC 79
            E G   T     C  +QF+C N RCI+  W CDG +DC DGSDE  +C  KTC  S F C
Sbjct: 2722 EHGEDETHCNKFCSEAQFECQNHRCISKQWLCDGSDDCGDGSDEAAHCEGKTCGPSSFSC 2781

Query: 80   -NNGQCVPSRWKCDGDPDCEDGSDESPEQ--CHMRTCRIHEISCGAHSTQCIPVSWRCDG 136
                 CVP RW CDGD DC DG+DES      +  TC   E  C   + QCIP  + CD 
Sbjct: 2782 PGTHVCVPERWLCDGDKDCADGADESIAAGCLYNSTCDDREFMC--QNRQCIPKHFVCDH 2839

Query: 137  ENDCDSGEDEE-NCGNITCSPDEFTCSSGRCI-SRNFVCNGQDDCSDGSDELDCAP--PT 192
            + DC  G DE   C   TC P EF C++GRC+ SR + C+G++DC D SDE   AP  P 
Sbjct: 2840 DRDCADGSDESPECEYPTCGPSEFRCANGRCLSSRQWECDGENDCHDQSDE---APKNPH 2896

Query: 193  CGAHEFQCSTSS--------CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEI 244
            C + E +C+ SS        C+  + +C+   DC D SDE                    
Sbjct: 2897 CTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDER------------------- 2937

Query: 245  QCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCV 304
             C   EC+ +K       DC+D      C    CRP     +DG       +C+    C 
Sbjct: 2938 GCHINECLSRK-LSGCSQDCEDLKIGFKC---RCRPGFRLKDDGRTCADVDECSTTFPCS 2993

Query: 305  DGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHI---NECL 361
                 +N     +CL    +  R G+      V ++E      +   L++ ++   N  L
Sbjct: 2994 QRC--INTHGSYKCLCVEGYAPRGGDPHSCKAVTDEEPFLIFANRYYLRKLNLDGSNYTL 3051

Query: 362  VNNGGCSHICKDL----VIGYECDCAAGFELIDRK--TCGDIDECQNPGICSQ--ICINL 413
            +  G  + +  D      + Y  D      +I R      ++      G+ +   + ++ 
Sbjct: 3052 LKQGLNNAVALDFDYREQMIYWTDVTTQGSMIRRMHLNGSNVQVLHRTGLSNPDGLAVDW 3111

Query: 414  KGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEY--IQLVEQLRNT 471
             GG    C +G                        RD  ++      Y  + +   LR  
Sbjct: 3112 VGGNLYWCDKG------------------------RDTIEVSKLNGAYRTVLVSSGLREP 3147

Query: 472  VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
             AL  D+    L+W D    ++      D   R V +   +  P  + +D+V + IYW D
Sbjct: 3148 RALVVDVQNGYLYWTDWGDHSLIGRIGMDGSSRSVIVDTKITWPNGLTLDYVTERIYWAD 3207

Query: 532  AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
            A    I  A+LDG+ R  + + D+  P   A+     +VYW+DW E   I +A       
Sbjct: 3208 AREDYIEFASLDGSNRHVVLSQDI--PHIFALTLFEDYVYWTDW-ETKSINRAHKTTGTN 3264

Query: 592  RPLVTADIQWP 602
            + L+ + +  P
Sbjct: 3265 KTLLISTLHRP 3275



 Score =  164 bits (415), Expect = 3e-40
 Identities = 117/372 (31%), Positives = 177/372 (47%), Gaps = 30/372 (8%)

Query: 398 DECQNPGICSQICI--NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRD--IRK 453
           D+   PG CS IC+  N      C C  G+ +      CK    E  L++   R   IR 
Sbjct: 481 DQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGKGRPGIIRG 540

Query: 454 IGLERK---EYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMID 510
           + +  K   E++  +E L N  ALD       +++AD +   I    ID    R   + D
Sbjct: 541 MDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDG-TERETILKD 599

Query: 511 NVYNPAAIAVDWVYKTIYWTD-AASKTISVATLD--GTKRKFLFNSDLREPASIAVDPLS 567
            ++N   +AVDW+   +YWTD    KTISVA L+     RK L    +  P +I VDPL+
Sbjct: 600 GIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLN 659

Query: 568 GFVYWSDWGEPAK------IEKAGMNGFDRRPLVTAD-IQWPNGITLDLIKSRLYWLDSK 620
           G++YW+DW E  K      +E+A M+G  R   VT+  + WPNG++LD+   RLYW+D+ 
Sbjct: 660 GWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAF 719

Query: 621 LHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELAT 680
              + ++ LNG DR+IV +  E L H   L    + ++W +  + +VY   +  G    T
Sbjct: 720 YDRIETILLNGTDRKIVYEGPE-LNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPT 778

Query: 681 LVNNLNDAQ---DIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
           +    ++     +I +Y    Q  G N C   + NGGC  LCL  P          C+C 
Sbjct: 779 VTLLRSERPPIFEIRMYDAQQQQVGTNKCR--VNNGGCSSLCLATPGSRQ------CACA 830

Query: 738 SGYNVEENGRDC 749
               ++ +G  C
Sbjct: 831 EDQVLDADGVTC 842



 Score =  162 bits (410), Expect = 1e-39
 Identities = 105/357 (29%), Positives = 177/357 (49%), Gaps = 22/357 (6%)

Query: 402  NPGICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
            N G CSQ+C+      + C C+ GY +      C+ VG    L+++    IR I L+  +
Sbjct: 1853 NNGDCSQLCLPTSETTRSCMCTAGYSLRSGQQACEGVGS--FLLYSVHEGIRGIPLDPND 1910

Query: 461  YIQLVEQLRNT---VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAA 517
                +  +  T   V +D       ++W D+    I  A   D+  R   + + +     
Sbjct: 1911 KSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISRAK-RDQTWREDVVTNGIGRVEG 1969

Query: 518  IAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGE 577
            IAVDW+   IYWTD     I VA L+G+ R  + +  L +P +I V P  G+++W++WG+
Sbjct: 1970 IAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVISQGLDKPRAITVHPEKGYLFWTEWGQ 2029

Query: 578  PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL-NGQDRRI 636
              +IE++ ++G +R  LV   I WPNGI++D    +LYW D++   +  +DL  G++R +
Sbjct: 2030 YPRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYWCDARTDKIERIDLETGENREV 2089

Query: 637  VLKSLEFLAHPLALTIFEDRVYWID--GENEAVYGANKFTGSELATLVNNLN-DAQDIIV 693
            VL S        ++++FED +YW D    N ++   +K   ++   L   +    +DI V
Sbjct: 2090 VLSSNNM--DMFSVSVFEDFIYWSDRTHANGSIKRGSKDNATDSVPLRTGIGVQLKDIKV 2147

Query: 694  YHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
            ++   Q  G N C   + NGGC+ LCL   +      +  C+C  G  + E+G  C+
Sbjct: 2148 FNRDRQ-KGTNVCA--VANGGCQQLCLYRGR-----GQRACACAHGM-LAEDGASCR 2195



 Score =  147 bits (371), Expect = 4e-35
 Identities = 93/268 (34%), Positives = 123/268 (45%), Gaps = 39/268 (14%)

Query: 146  EENCGNITCSPDEFTCSSGRCI----SRNFVCNGQDDCSDGSDELDCA-------PPTCG 194
            ++  G   C  +   CSS  C+    SR   C  +D   D +D + C        PP C 
Sbjct: 799  QQQVGTNKCRVNNGGCSS-LCLATPGSRQCAC-AEDQVLD-ADGVTCLANPSYVPPPQCQ 855

Query: 195  AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHK 254
              EF C+ S CI   W CD D DC D SDE+   C +    HT CP+   +C +  CI  
Sbjct: 856  PGEFACANSRCIQERWKCDGDNDCLDNSDEAPALCHQ----HT-CPSDRFKCENNRCIPN 910

Query: 255  KWRCDGDPDCKDGSDEVN--CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
            +W CDGD DC +  DE N  C +RTC P+QF C  G CI  S  C+   DC D SDE   
Sbjct: 911  RWLCDGDNDCGNSEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESAS 970

Query: 313  KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICK 372
                 C    +F C +G CI+I+  C+ + DC D SDE               GCSH C 
Sbjct: 971  CAYPTCFPLTQFTCNNGRCININWRCDNDNDCGDNSDE--------------AGCSHSCS 1016

Query: 373  DLVIGYECDCAAGFELIDRKTCGDIDEC 400
                  +  C +G  + +  TC   ++C
Sbjct: 1017 ST----QFKCNSGRCIPEHWTCDGDNDC 1040



 Score =  146 bits (369), Expect = 7e-35
 Identities = 99/356 (27%), Positives = 166/356 (46%), Gaps = 20/356 (5%)

Query: 404  GICSQIC-INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
            G CS +C IN      C C    ++      C    K   L++  + +IR + L+   Y 
Sbjct: 1547 GPCSHLCLINYNRTVSCACPHLMKLHKDNTTCYEFKK--FLLYARQMEIRGVDLDAPYYN 1604

Query: 463  QLVE----QLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
             ++      + N   LD D   Q+++W+D+  +AI  A I+   G    +  ++ N   +
Sbjct: 1605 YIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAIKRAFING-TGVETVVSADLPNAHGL 1663

Query: 519  AVDWVYKTIYWT--DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG 576
            AVDWV + ++WT  D   K I+VA LDG+ +  +    L +P  + V PL G +YW+D  
Sbjct: 1664 AVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVVQG-LEQPHGLVVHPLRGKLYWTDGD 1722

Query: 577  EPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRI 636
                I  A M+G +R  L +   + P G+ +D  +S+LYW+ S  H ++  +L+G    +
Sbjct: 1723 N---ISMANMDGSNRTLLFSGQ-KGPVGLAIDFPESKLYWISSGNHTINRCNLDGSGLEV 1778

Query: 637  VLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHE 696
            +      L    AL I  D+++W D  +E +   +K  GS    L N+      + VY E
Sbjct: 1779 IDAMRSQLGKATALAIMGDKLWWADQVSEKMGTCSKADGSGSVVLRNSTTLVMHMKVYDE 1838

Query: 697  LVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRI 752
             +Q   K      + NG C  LCLP  +        +C C +GY++    + C+ +
Sbjct: 1839 SIQLDHKGTNPCSVNNGDCSQLCLPTSETT-----RSCMCTAGYSLRSGQQACEGV 1889



 Score =  120 bits (302), Expect = 4e-27
 Identities = 93/375 (24%), Positives = 167/375 (44%), Gaps = 42/375 (11%)

Query: 404  GICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
            G C Q+C+    G + C C+ G   +      +  G    L+++ R  ++ I L  +  +
Sbjct: 2164 GGCQQLCLYRGRGQRACACAHGMLAEDGASCREYAGY---LLYSERTILKSIHLSDERNL 2220

Query: 463  QLV-------EQLRNTVALDADIAA-------QKLFWADLSQKAIFSASIDDKVGRHVKM 508
                      E ++N +AL  D  A        ++F++D+    I    I+D   R + +
Sbjct: 2221 NAPVQPFEDPEHMKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNI--QQINDDGSRRITI 2278

Query: 509  IDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK------RKFLFNSDLREPASIA 562
            ++NV +   +A    + T+YWT   + TI+  T+D T+         +  S    P +  
Sbjct: 2279 VENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFV 2338

Query: 563  VDPLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKL 621
            +D     ++W++W E    I +A ++G +   L+  DI+ PNG+ +D    +LY+ D+ L
Sbjct: 2339 LDECQNLMFWTNWNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATL 2398

Query: 622  HMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATL 681
              +   + +G  R ++LKS     HP  L ++ + ++W D    AV  ANK  GS +  L
Sbjct: 2399 DKIERCEYDGSHRYVILKSEP--VHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLL 2456

Query: 682  VNNLNDAQDIIVYHELVQPSGKNWCEED---MENGGCEYLCLPAPQINDHSPKYTCSCPS 738
              ++      I+       +  N CE     + NGGC+ LCL       H     CSC  
Sbjct: 2457 RVDIPQQPMGII----AVANDTNSCELSPCRINNGGCQDLCLLT-----HQGHVNCSCRG 2507

Query: 739  GYNVEENGRDCQRIN 753
            G  + ++   C+ +N
Sbjct: 2508 G-RILQDDLTCRAVN 2521



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 43/132 (32%), Positives = 62/132 (46%), Gaps = 22/132 (16%)

Query: 70  KTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQC---HMRTCRIHEISCGAHST 125
           KTC+   F C +   C+   W+CDG+ DC DGSDE+PE C     + C+ +E +C   + 
Sbjct: 25  KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNC-LGTE 83

Query: 126 QCIPVSWRCDGENDCDSGEDE--------ENCGNITC---------SPDEFTCSSGRCIS 168
            C+P+S  C+G  DC  G DE         NC  + C          P  +  SS +  +
Sbjct: 84  LCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQA 143

Query: 169 RNFVCNGQDDCS 180
               C   D+CS
Sbjct: 144 DGKTCKDFDECS 155



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 56/180 (31%), Positives = 77/180 (42%), Gaps = 27/180 (15%)

Query: 153 TCSPDEFTCSSG-RCISRNFVCNGQDDCSDGSDELDCAPP-----TCGAHEFQC-STSSC 205
           TCSP +F C     CIS+ + C+G+ DC DGSDE     P      C  +E  C  T  C
Sbjct: 26  TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELC 85

Query: 206 IPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCK 265
           +P+S +C+   DC D SDE              C   +  C    C H        P C 
Sbjct: 86  VPMSRLCNGVQDCMDGSDEG-----------PHCRELQGNCSRLGCQHHCVPTLDGPTCY 134

Query: 266 -DGSDEVNCPSRTCRPDQFECE-DGSCIHGSRQCNG--IRDCVDG----SDEVNCKNVNQ 317
            + S ++    +TC+ D  EC   G+C       +G  I  CV+G     D  +CK  N+
Sbjct: 135 CNSSFQLQADGKTCK-DFDECSVYGTCSQLCTNTDGSFICGCVEGYLLQPDNRSCKAKNE 193



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 38/104 (36%), Positives = 49/104 (47%), Gaps = 11/104 (10%)

Query: 33  CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDE-----KNCVKKTCAESDFVCNNGQ-CV 85
           C P QF C +   CI+  W+CDG+ DC DGSDE          + C  ++  C   + CV
Sbjct: 27  CSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCV 86

Query: 86  PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIP 129
           P    C+G  DC DGSDE P  C         + C  H   C+P
Sbjct: 87  PMSRLCNGVQDCMDGSDEGP-HCRELQGNCSRLGCQHH---CVP 126



 Score = 33.5 bits (75), Expect = 0.85
 Identities = 14/35 (40%), Positives = 19/35 (54%)

Query: 349 DEPLKECHINECLVNNGGCSHICKDLVIGYECDCA 383
           D   ++   N+C VNNGGCS +C       +C CA
Sbjct: 796 DAQQQQVGTNKCRVNNGGCSSLCLATPGSRQCACA 830



 Score = 31.2 bits (69), Expect = 4.2
 Identities = 15/46 (32%), Positives = 21/46 (45%), Gaps = 6/46 (13%)

Query: 706  CEE-DMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQ 750
            C++  + NGGC + C  AP          CSCP G  +  +   CQ
Sbjct: 1182 CDQCSLNNGGCSHNCSVAP-----GEGIVCSCPLGMELGPDNHTCQ 1222


>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
          Length = 4655

 Score =  522 bits (1345), Expect = e-148
 Identities = 290/776 (37%), Positives = 397/776 (51%), Gaps = 87/776 (11%)

Query: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTC-AESDFVCNNGQCVPSR--- 88
            C P+ F C NGRC+   ++CD   DC DGSDE  C+ + C A ++F+CNN +C+P     
Sbjct: 2741 CSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFIC 2800

Query: 89   ---------------------------------------WKCDGDPDCEDGSDESPEQCH 109
                                                   + CDGD DC D SDE+P  C 
Sbjct: 2801 NGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCT 2860

Query: 110  MRTCRIHEISCGAHSTQCIPVSWRCDGENDC-DSGEDEENCGNI--TCSPDEFTCSSGRC 166
              TC   E  C   S +CIP  W CD E DC D+ ++  +CG+   TC  DEF C  GRC
Sbjct: 2861 THTCSSSEFQCA--SGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRC 2918

Query: 167  ISRNFVCNGQDDCSDGSDE---LDCAPPTCGAHEFQCSTSS-----CIPISWVCDDDADC 218
            I   ++C+G +DC D SDE     C    C   EF C         CIP SWVCD D DC
Sbjct: 2919 IPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDC 2978

Query: 219  SDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTC 278
            +D  DE+ + C R+      C  +E  CG G CI K +RCD   DC D SDE  C  +TC
Sbjct: 2979 TDGYDEN-QNCTRRT-----CSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTC 3032

Query: 279  RPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVN--CKNVNQCLGPGKFKCRSGECIDISK 336
            + +QF C++G CI  +  C+   DC DGSDE+   C        P +FKC +G CI++ K
Sbjct: 3033 QQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMK 3092

Query: 337  VCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHICKDLVIGYECDCAAGFELI-DRKTC 394
            +CN   DC D SDE  K C INEC   +  GC H C D +  + C C  G++L+ D++TC
Sbjct: 3093 LCNHLDDCLDNSDE--KGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTC 3150

Query: 395  GDIDEC-QNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK-EPSLIFTNRRDIR 452
             DIDEC + P +CSQ C N+ G Y C+C+ GY  +     C+     EP LIF+NR  +R
Sbjct: 3151 VDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLR 3210

Query: 453  KIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512
             + ++   Y  ++E L N VALD D   ++L+W D +Q+ +      +K  +   +   +
Sbjct: 3211 NLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWID-TQRQVIERMFLNKTNKETIINHRL 3269

Query: 513  YNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR--------EPASIAVD 564
                ++AVDWV + +YW DA    + V+ L+G  R+ L    +          P  +A+ 
Sbjct: 3270 PAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALH 3329

Query: 565  PLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHML 624
            P  G++YW+DWG  A I + GM+G ++  +++  ++WPNGIT+D     LYW D+ L  +
Sbjct: 3330 PQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYI 3389

Query: 625  SSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNN 684
               DL G  R  V      L HP A+TIFED +YW D     V   NK+ GS   TLVN 
Sbjct: 3390 EYSDLEGHHRHTVYDGA--LPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNT 3447

Query: 685  LNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
             +   DI VYH   QP   N C     NGGC +LCL    I      +TC CP  +
Sbjct: 3448 THRPFDIHVYHPYRQPIVSNPC--GTNNGGCSHLCL----IKPGGKGFTCECPDDF 3497



 Score =  505 bits (1301), Expect = e-143
 Identities = 284/746 (38%), Positives = 396/746 (53%), Gaps = 32/746 (4%)

Query: 21   ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFV 78
            E   T      +C    F C NGRC+   + CDG +DC D SDE+ C  +  TC+ S F 
Sbjct: 1014 EGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFT 1073

Query: 79   CNNGQCVPSRWKCDGDPDCEDGSDESPEQCHM-RTCRIHEISCGAHSTQCIPVSWRCDGE 137
            C +G+C+P+ W+CD   DC DGSDE     H   +C   + +C  H  QCI  +W CD +
Sbjct: 1074 CGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNH--QCISKNWVCDTD 1131

Query: 138  NDCDSGEDEENCGNI-TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAH 196
            NDC  G DE+NC +  TC P +F C + RCI  +FVC+G  DC DGSDE+ C    C A 
Sbjct: 1132 NDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVL-NCTAS 1190

Query: 197  EFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGS-GECIHK 254
            +F+C++   CI ++  CD   DCSD SDE+   C  +P     C + E QC   G CI  
Sbjct: 1191 QFKCASGDKCIGVTNRCDGVFDCSDNSDEA--GCPTRPP--GMCHSDEFQCQEDGICIPN 1246

Query: 255  KWRCDGDPDCKDGSDEVN-CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
             W CDG PDC  GSDE N C  +TC    F C++G+CIH +  C+   DC D SDE +C 
Sbjct: 1247 FWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCP 1306

Query: 314  NVNQCLGPGKFKCRSGE-CIDISKVCNQEQDCRDWSDE-PLKECHINECLVNNGGCSHIC 371
                     +++C     C+++S VC+   DC + +DE PL  C+ N C   NGGC+H C
Sbjct: 1307 TQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPL--CNGNSCSDFNGGCTHEC 1364

Query: 372  KDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLA 430
                 G +C C  GF L  D KTC DIDEC   G CSQ C N++G ++C C  GY ++  
Sbjct: 1365 VQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESD 1424

Query: 431  TGVCKAVGKEPSLIFT---NRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWAD 487
               CK    E  L+     N+     +  +      LVE     VA+D D  + ++FW+D
Sbjct: 1425 GRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSD 1484

Query: 488  LSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
             +Q   +SA   +   R V    ++     IA+DWV + +YWTD A +TI V+ +DG+ R
Sbjct: 1485 ATQGKTWSA-FQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHR 1543

Query: 548  KFLFNSDLREPASIAVDPLSG--FVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGI 605
              L + +L  P  +A+DP      ++WSDWG   +IE+A M+G  R  +V   I WP G+
Sbjct: 1544 TVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGL 1603

Query: 606  TLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENE 665
            T+D     LY++DS L  +   D NG  RR V+ S   + HP ALT+FED VYW D    
Sbjct: 1604 TIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATR 1663

Query: 666  AVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQI 725
             V  ANK+ G   + ++ N+     I+  H   QP+  N C        C +LCL + Q 
Sbjct: 1664 RVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSR----CSHLCLLSSQ- 1718

Query: 726  NDHSPKYTCSCPSGYNVEENGRDCQR 751
              H   Y+C CPSG+++  +  +C R
Sbjct: 1719 GPHF--YSCVCPSGWSLSPDLLNCLR 1742



 Score =  484 bits (1245), Expect = e-136
 Identities = 285/803 (35%), Positives = 403/803 (50%), Gaps = 115/803 (14%)

Query: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE--KNCVKKTCAESDFVCNNGQCVPSRWK 90
            C+ +++QC N RCI   W+CD   DC D SDE   +C  +TC    F C NG+C+P  WK
Sbjct: 3594 CDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWK 3653

Query: 91   CDGDPDCEDGSDESPEQC----HM------------------------------------ 110
            CD D DC D SDE  E+C    H+                                    
Sbjct: 3654 CDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQG 3713

Query: 111  ---RTCR-IHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRC 166
               RTC  + +  C  H   CIP+ W+CDG+NDC    DEENC    C+  EF C + +C
Sbjct: 3714 CEERTCHPVGDFRCKNH--HCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQC 3771

Query: 167  ISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESL 226
            I   ++C+  +DC D SDE DC   TC    FQC++  C+     CD  ADC D SDE+ 
Sbjct: 3772 IPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEA- 3830

Query: 227  EQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVN--CPSRTCR-PDQF 283
              C  +      C A+  +C +  CI   W+CDGD DC DGSDE    C    C  P++F
Sbjct: 3831 -DCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRF 3889

Query: 284  ECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPG-------KFKCRSGECIDISK 336
             C++  CI+    CNG+ DC DG+DE        C  P        ++KC +G CI    
Sbjct: 3890 RCDNNRCIYSHEVCNGVDDCGDGTDETE----EHCRKPTPKPCTEYEYKCGNGHCIPHDN 3945

Query: 337  VCNQEQDCRDWSDE------PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFE--L 388
            VC+   DC DWSDE        + C  N C  N   C+ + +    G+ C C AGFE  +
Sbjct: 3946 VCDDADDCGDWSDELGCNKGKERTCAENICEQN---CTQLNEG---GFICSCTAGFETNV 3999

Query: 389  IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGY--QMDLATGVCKAVGKEPSLIFT 446
             DR +C DI+EC+  G C Q C N KG Y+C C+ G+    D     C A G  P L+  
Sbjct: 4000 FDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLP 4059

Query: 447  NRRDIRKIGLERKEYIQLVEQLRNTVALD-----ADIAAQKLFWADLSQKAIFSA----- 496
            +   IRK  L  + + + ++      A+D      DI    +++    + + F A     
Sbjct: 4060 DNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAY 4119

Query: 497  --SIDDKVGRHVKMID----NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFL 550
              + +      V+ +D     V  P  IAVDWV + IYW+D  +K I VA LDG  RK+L
Sbjct: 4120 IPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWL 4179

Query: 551  FNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
             ++DL +PA+IAV+P  G ++W+DWG+  KIE A MNG DR  LV  D+ WP G+++D +
Sbjct: 4180 ISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYL 4239

Query: 611  KS-RLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYG 669
             + R+YW D K  ++ ++  +G DRR++ K      +P +L IFED++YWI  E   V+ 
Sbjct: 4240 NNDRIYWSDFKEDVIETIKYDGTDRRVIAKE---AMNPYSLDIFEDQLYWISKEKGEVWK 4296

Query: 670  ANKF-TGSELATLVNNLNDAQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQIND 727
             NKF  G +  TLV N    Q + ++H+L    S  N C++      C +LCL  P    
Sbjct: 4297 QNKFGQGKKEKTLVVNPWLTQ-VRIFHQLRYNKSVPNLCKQI-----CSHLCLLRP---- 4346

Query: 728  HSPKYTCSCPSGYN-VEENGRDC 749
                Y+C+CP G + +E +  +C
Sbjct: 4347 --GGYSCACPQGSSFIEGSTTEC 4367



 Score =  454 bits (1169), Expect = e-127
 Identities = 264/760 (34%), Positives = 381/760 (50%), Gaps = 86/760 (11%)

Query: 9   LWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV 68
           L L L  C AP    A+G     +C+ + F+C +G CI   W+CDG +DC D +DE  C 
Sbjct: 12  LLLALVACLAP----ASGQ----ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCA 63

Query: 69  KKTCAESDFVC-NNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQC 127
             TC +  F C + GQC+P+ W CD D DC+DGSDE  + C   TC  H+I+C   + QC
Sbjct: 64  VVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDER-QDCSQSTCSSHQITCS--NGQC 120

Query: 128 IPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD 187
           IP  +RCD   DC  G DE +C   TC  ++ TC +G C + +  C+ + DC D SDE++
Sbjct: 121 IPSEYRCDHVRDCPDGADENDCQYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEIN 178

Query: 188 CAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
           C    C  +EF C    CIP ++VCD D DC D SDE    C      +  C   +  C 
Sbjct: 179 CT-EICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDE--HACN-----YPTCGGYQFTCP 230

Query: 248 SGECIHKKWRCDGDPDCKDGSDEVNCPS-----RTCRPDQFEC-EDGSCIHGSRQCNGIR 301
           SG CI++ W CDG+ DCKD  DE  C S       C P ++ C E G CI   + C+GI 
Sbjct: 231 SGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGIL 290

Query: 302 DCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECL 361
           DC    DE N          GK+                              C +  C 
Sbjct: 291 DCPGREDENNTST-------GKY------------------------------CSMTLCS 313

Query: 362 VNNGGCSHICKDLVIGYECDCAAGFEL--IDRKTCGDIDECQNPGICSQICINLKGGYKC 419
             N  C + C +   G  C C  G+ +   D +TC + D+CQ  GIC Q C +  G + C
Sbjct: 314 ALN--CQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLC 371

Query: 420 ECSRGYQMDLATGVCKAVGK--EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDA- 476
            C  GY ++     CKA     E S+IF+N RD+    +  + +  LVE     VA+   
Sbjct: 372 HCEEGYILERGQ-YCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVA 430

Query: 477 -DIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDN--VYNPAAIAVDWVYKTIYWTDAA 533
                Q++FW D  Q  +FS  I+   G +++ + N  V  P  +AVDWV   IY  +  
Sbjct: 431 FHYHLQRVFWTDTVQNKVFSVDIN---GLNIQEVLNVSVETPENLAVDWVNNKIYLVETK 487

Query: 534 SKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW----GEPAKIEKAGMNGF 589
              I +  LDG+ R  L   +L  P  IAVDP  G++++SDW    GEP K+E+A M+G 
Sbjct: 488 VNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEP-KLERAFMDGS 546

Query: 590 DRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLA 649
           +R+ LV   + WP G+TLD+I  R+YW+DS+   + +V  +G  R+ V+     + HP  
Sbjct: 547 NRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFG 606

Query: 650 LTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709
           +++FE +V++ D    AV  ANKFT +              + VYH L QP   N C+++
Sbjct: 607 VSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDN 666

Query: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
             NGGCE +C+ + + ++    + C C  G+ ++ + R C
Sbjct: 667 --NGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHC 704



 Score =  189 bits (481), Expect = 7e-48
 Identities = 118/308 (38%), Positives = 150/308 (48%), Gaps = 31/308 (10%)

Query: 32   KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKC 91
            +C  S+F+C N +CI   W CD   DC D SDE++C  +TC    F C +G CV S  KC
Sbjct: 3758 ECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKC 3817

Query: 92   DGDPDCEDGSDESPEQCHMR-----TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146
            DG  DC D SDE+   C  R      C+     C  H   CIP  W+CDG++DC  G DE
Sbjct: 3818 DGSADCLDASDEA--DCPTRFPDGAYCQATMFECKNH--VCIPPYWKCDGDDDCGDGSDE 3873

Query: 147  E--NCGNITC-SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD--CAPPT---CGAHEF 198
            E   C ++ C SP+ F C + RCI  + VCNG DDC DG+DE +  C  PT   C  +E+
Sbjct: 3874 ELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEY 3933

Query: 199  QCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQ-PVIHTKCPASEIQCGSGECIHKKWR 257
            +C    CIP   VCDD  DC D SDE     G++       C  +  Q   G  I     
Sbjct: 3934 KCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFI----- 3988

Query: 258  CDGDPDCKDGSDEVNCPSRTCRPDQFECED-GSCIHGSRQCNGIRDCV--DGSDEVNCKN 314
            C     C  G  E N   RT   D  ECE  G+C    R   G  +CV  DG   ++ + 
Sbjct: 3989 C----SCTAGF-ETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRP 4043

Query: 315  VNQCLGPG 322
              +C   G
Sbjct: 4044 GKRCAAEG 4051



 Score =  178 bits (452), Expect = 2e-44
 Identities = 110/361 (30%), Positives = 178/361 (49%), Gaps = 24/361 (6%)

Query: 402  NPGICSQICI------NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
            N G C Q+C+      N   G++C+C+ G+Q+D     C AV  +  LIF+++  IR I 
Sbjct: 666  NNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAV--QNFLIFSSQVAIRGIP 723

Query: 456  LERKEYIQLVEQLRNT----VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDN 511
                    ++  +       V +D D     +F++D+S+  IF   ID   GR +   + 
Sbjct: 724  FTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDG-TGREILAANR 782

Query: 512  VYNPAAIAVDWVYKTIYWTDAASKTISVATL-DGTKRKFLFNSDLREPASIAVDPLSGFV 570
            V N  ++A DW+ K +YWTD+  K+ISV  L D T+R  +    L  P S+ V P +G++
Sbjct: 783  VENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV--QYLNNPRSVVVHPFAGYL 840

Query: 571  YWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLN 630
            +++DW  PAKI +A  +G    P++   + WPNG+ +D   SRLYW+D+    +     +
Sbjct: 841  FFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFD 900

Query: 631  GQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQD 690
            G DRR  L  +E + HP  L IF + +++ D    A+    K  G E+  + + +     
Sbjct: 901  GLDRR-RLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILH 959

Query: 691  IIVYHELVQPSGKNWCEEDME-NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
            +  Y   +Q +G N C +    NG C + C P P       +  C CP G  +  N   C
Sbjct: 960  LKSYDVNIQ-TGSNACNQPTHPNGDCSHFCFPVPNF-----QRVCGCPYGMRLASNHLTC 1013

Query: 750  Q 750
            +
Sbjct: 1014 E 1014



 Score =  163 bits (413), Expect = 5e-40
 Identities = 109/407 (26%), Positives = 183/407 (44%), Gaps = 65/407 (15%)

Query: 354  ECHINECLVNNGGCSHICKDL--VIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICI 411
            E + N CL NNGGCSH+C  L  +   +CDCA G    D K C                 
Sbjct: 2340 EVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNC----------------- 2382

Query: 412  NLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEY---IQLVEQL 468
                                    A+  E  LIF     +R + L+ + +    Q +   
Sbjct: 2383 ------------------------AISTENFLIFALSNSLRSLHLDPENHSPPFQTINVE 2418

Query: 469  RNTVALDADIAAQKLFWADLSQKA---IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYK 525
            R  ++LD D  + ++++          I  A++   +     +   +     IA DW+ +
Sbjct: 2419 RTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITR 2478

Query: 526  TIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAG 585
             IY++D  ++ I+    DG+ R  +  + + +P +I +DP  G++YW+DW   AKIE+A 
Sbjct: 2479 RIYYSDYLNQMINSMAEDGSNRTVI--ARVPKPRAIVLDPCQGYLYWADWDTHAKIERAT 2536

Query: 586  MNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLA 645
            + G  R P+V + +  P+G+TLD  +  LYW+D+ L  +    L G DR +++ +     
Sbjct: 2537 LGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNA---AV 2593

Query: 646  HPLALTIFEDRVYWIDGENEAVYGANKFTGS-ELATLVNNLNDAQDIIVYHELVQPSGKN 704
            H   LT++   +YW D   + +Y ANK+ GS ++A   N L+  + I    +  +    N
Sbjct: 2594 HAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNN 2653

Query: 705  WCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP--SGYNVEENGRDC 749
             CE+   NGGC ++C P P   +      C CP    + +  N + C
Sbjct: 2654 PCEQ--FNGGCSHICAPGPNGAE------CQCPHEGNWYLANNRKHC 2692



 Score =  152 bits (385), Expect = 1e-36
 Identities = 100/373 (26%), Positives = 189/373 (50%), Gaps = 40/373 (10%)

Query: 402  NPGICSQICINLKGG-YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKE 460
            N   C QIC+ + GG + C C+ G++++     C        ++ +    IR   LE  +
Sbjct: 2025 NMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNS--FIVVSMLSAIRGFSLELSD 2082

Query: 461  Y----IQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK----MIDNV 512
            +    + +  Q RN + +D D+++  ++W D S     S+   D   R +K     + N+
Sbjct: 2083 HSETMVPVAGQGRNALHVDVDVSSGFIYWCDFS-----SSVASDNAIRRIKPDGSSLMNI 2137

Query: 513  YNPA-------AIAVDWVYKTIYWTDA--ASKTISVATLDGTKRKFLFNSDLREPASIAV 563
                        IAVDWV   +Y+T+A  +   I V  ++ T R+ L    +  P  I V
Sbjct: 2138 VTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVV 2197

Query: 564  DPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHM 623
            DP + +++W+D+G+  KIE++ ++  +R  LV+  I  P G+ +D     +YW+D  L +
Sbjct: 2198 DPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDI 2257

Query: 624  LSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKF-TGSELATLV 682
            ++ + +NG++  ++     +   P  +T+FE+ + W+D   + ++ A+K    +E  T++
Sbjct: 2258 IARIRINGENSEVIRYGSRY-PTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVI 2316

Query: 683  -NNLNDAQDIIVYHELVQPS-----GKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
             +N+N  +D+ ++ + VQP        N C E+  NGGC +LC   P +  H+PK  C C
Sbjct: 2317 RDNINWLRDVTIFDKQVQPRSPAEVNNNPCLEN--NGGCSHLCFALPGL--HTPK--CDC 2370

Query: 737  PSGYNVEENGRDC 749
              G  ++ +G++C
Sbjct: 2371 AFG-TLQSDGKNC 2382



 Score =  136 bits (343), Expect = 7e-32
 Identities = 99/375 (26%), Positives = 173/375 (46%), Gaps = 30/375 (8%)

Query: 406  CSQICINLKGG---YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGL----ER 458
            CS +C+    G   Y C C  G+ +      C     +P LI   +  I  I L    + 
Sbjct: 1709 CSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLR-DDQPFLITVRQHIIFGISLNPEVKS 1767

Query: 459  KEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
             + +  +  ++N + ++ D A Q ++W + +   I     D         I  V     +
Sbjct: 1768 NDAMVPIAGIQNGLDVEFDDAEQYIYWVE-NPGEIHRVKTDGTNRTVFASISMVGPSMNL 1826

Query: 519  AVDWVYKTIYWTDAASKTISVATLDGT--KRKFLFNSD-----LREPASIAVDPLSGFVY 571
            A+DW+ + +Y T+  +++I V TL G    RK L  +D     +  P  I VDP  G +Y
Sbjct: 1827 ALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLY 1886

Query: 572  WSDWGE----PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
            WSD G     PAKI  A M+G   + L T +++    +TLD+ + +LYW  +   ++   
Sbjct: 1887 WSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERG 1946

Query: 628  DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
            +++G DR I++     L+HP  + + +  +Y+ D + E +   +K TG+    L +N+ +
Sbjct: 1947 NVDGTDRMILVHQ---LSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPN 2003

Query: 688  AQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGR 747
             + + VYH        N C  +M    C+ +CLP P        ++C+C +G+ +  + R
Sbjct: 2004 LRGLQVYHRRNAAESSNGCSNNM--NACQQICLPVP-----GGLFSCACATGFKLNPDNR 2056

Query: 748  DCQRINVTTAVSEVS 762
             C   N    VS +S
Sbjct: 2057 SCSPYNSFIVVSMLS 2071



 Score =  135 bits (341), Expect = 1e-31
 Identities = 74/237 (31%), Positives = 117/237 (49%), Gaps = 25/237 (10%)

Query: 191  PTCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG 249
            P C + +F C+ +  CIPI W CD   DCSD SDE L  C ++      C   + QC  G
Sbjct: 3510 PMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDE-LALCPQR-----FCRLGQFQCSDG 3563

Query: 250  ECIHKKWRCDGDPDCKDGSDE--VNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
             C   +  C+   +C DGSDE  + C +  C  ++++C +  CI  S QC+   DC D S
Sbjct: 3564 NCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNS 3623

Query: 308  DEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGC 367
            DE +    ++   PG+F+C +G CI  +  C+ + DC D SDEP++EC            
Sbjct: 3624 DEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECM---------SS 3674

Query: 368  SHICKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGI---CSQICINLKGGYKCE 420
            +H+C +     E  C   +  I +   C  +D+C++      C +   +  G ++C+
Sbjct: 3675 AHLCDNFT---EFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCK 3728



 Score =  103 bits (258), Expect = 5e-22
 Identities = 56/142 (39%), Positives = 74/142 (52%), Gaps = 12/142 (8%)

Query: 31   AKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKTC-AESDFVCNNGQCVPS 87
            A C+ + F+C N  CI   WKCDGD+DC DGSDE+   C+   C + + F C+N +C+ S
Sbjct: 3840 AYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYS 3899

Query: 88   RWKCDGDPDCEDGSDESPEQCHMRT---CRIHEISCGAHSTQCIPVSWRCDGENDCDSGE 144
               C+G  DC DG+DE+ E C   T   C  +E  CG  +  CIP    CD  +DC    
Sbjct: 3900 HEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCG--NGHCIPHDNVCDDADDCGDWS 3957

Query: 145  DEENCGNITCSPDEFTCSSGRC 166
            DE  C        E TC+   C
Sbjct: 3958 DELGCN----KGKERTCAENIC 3975



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 27/89 (30%), Positives = 36/89 (40%), Gaps = 17/89 (19%)

Query: 337  VCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDC--AAGFELIDRKTC 394
            V NQ+Q C             N C   NGGCSHIC     G EC C     + L + +  
Sbjct: 2644 VKNQKQQCN------------NPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKH 2691

Query: 395  GDIDECQNPGICSQICIN---LKGGYKCE 420
              +D  +  G  S  C N   +   +KC+
Sbjct: 2692 CIVDNGERCGASSFTCSNGRCISEEWKCD 2720



 Score = 30.8 bits (68), Expect = 5.5
 Identities = 23/80 (28%), Positives = 34/80 (42%), Gaps = 11/80 (13%)

Query: 677  ELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
            E+  L N+L+D  D    +   +  G N C  D    GC++ C       D    + CSC
Sbjct: 3089 EMMKLCNHLDDCLD----NSDEKGCGINECH-DPSISGCDHNC------TDTLTSFYCSC 3137

Query: 737  PSGYNVEENGRDCQRINVTT 756
              GY +  + R C  I+  T
Sbjct: 3138 RPGYKLMSDKRTCVDIDECT 3157


>gi|93102379 low density lipoprotein-related protein 1B precursor
            [Homo sapiens]
          Length = 4599

 Score =  518 bits (1333), Expect = e-146
 Identities = 278/740 (37%), Positives = 401/740 (54%), Gaps = 38/740 (5%)

Query: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKTCAESDFVCNNGQCVPSRWK 90
            C+  +F+C N  CI   WKCDGD+DC+DGSDE   NC   +C +  F C N +C+P RW 
Sbjct: 845  CKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWL 904

Query: 91   CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENC 149
            CDG  DC    DES + C  RTC++ + SCG  + +CIP +W CD E+DC    DE  +C
Sbjct: 905  CDGANDCGSNEDESNQTCTARTCQVDQFSCG--NGRCIPRAWLCDREDDCGDQTDEMASC 962

Query: 150  GNITCSP-DEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPI 208
               TC P  +F C SGRCIS  + C+  DDC DGSDE+ C   +C  ++F+CS+  CIP 
Sbjct: 963  EFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVH-SCFDNQFRCSSGRCIPG 1021

Query: 209  SWVCDDDADCSDQSDESLEQCGRQPVIHTK--CPASEIQCG-SGECIHKKWRCDGDPDCK 265
             W CD D DC D SDE+   C ++  IH+   C  +E QC   G C+   WRCDG+ DC+
Sbjct: 1022 HWACDGDNDCGDFSDEAQINCTKEE-IHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE 1080

Query: 266  DGSDEVNCPS--RTC-RPDQFEC-EDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP 321
            DGSDE  C    R C    +F C   G CI+ +  C+G  DC D SDE +C +     GP
Sbjct: 1081 DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSF--LCGP 1138

Query: 322  GKFKCRSGE--CIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV-IGY 378
             K  C +    C+   K+CN ++DC D SDE       +EC +NNGGCS+ C  +   G 
Sbjct: 1139 PKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYL---CDECSLNNGGCSNHCSVVPGRGI 1195

Query: 379  ECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
             C C  G +L  D KTC  +D C N   CSQ+C   K   KC C  G+++D+    C +V
Sbjct: 1196 VCSCPEGLQLNKDNKTCEIVDYCSNHLKCSQVCEQHKHTVKCSCYEGWKLDVDGESCTSV 1255

Query: 438  GK-EPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSA 496
               E  +IF+ R +IR+I L +++Y  LV  LRNT+ALD       L+W D+ +  I+  
Sbjct: 1256 DPFEAFIIFSIRHEIRRIDLHKRDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRG 1315

Query: 497  SIDDKVGR---HVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNS 553
             + +  G     V +   +  P  + VDW+   IYW D+    I VA LDG+ R  L   
Sbjct: 1316 KLSESGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLIAG 1375

Query: 554  DLREPASIAVDPLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQ---WPNGITLDL 609
             +  P +IA+DP  G ++W+DW     +IE A M+G  R+ +   D++   WPNG+T+D 
Sbjct: 1376 AMEHPRAIALDPRYGILFWTDWDANFPRIESASMSGAGRKTIYK-DMKTGAWPNGLTVDH 1434

Query: 610  IKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYG 669
             + R+ W D++   + S   +G +   +++  E+L+HP A++++   VYW D     +  
Sbjct: 1435 FEKRIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSK 1494

Query: 670  ANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHS 729
            ANK+TG  ++ +        D+ +YH   QP   N C  +   G C ++CL    IN H+
Sbjct: 1495 ANKWTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCL----IN-HN 1549

Query: 730  PKYTCSCPSGYNVEENGRDC 749
                C+CP    +  + + C
Sbjct: 1550 RSAACACPHLMKLSSDKKTC 1569



 Score =  499 bits (1286), Expect = e-141
 Identities = 280/743 (37%), Positives = 405/743 (54%), Gaps = 46/743 (6%)

Query: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAE--------SDFV-CNNGQ 83
            C   +F+C +G CI    +C+ + DC D SDEKNC    C          + F+ CN+  
Sbjct: 2591 CATVEFRCADGTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLGVKTTGFIRCNSTS 2650

Query: 84   -CVPSRWKCDGDPDCEDGSDE--SPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140
             CV   W CDG  DC D SDE   P Q +   C  +  SC   S +CI  +W CDG+ DC
Sbjct: 2651 LCVLPTWICDGSNDCGDYSDELKCPVQ-NKHKCEENYFSCP--SGRCILNTWICDGQKDC 2707

Query: 141  DSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD--CAPPTCGAHEF 198
            + G DE +C + +CS ++F CS+ +CIS++++C+G+DDC DG DE D  C   TC A  F
Sbjct: 2708 EDGRDEFHCDS-SCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSICGAITCAADMF 2766

Query: 199  QCSTS-SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWR 257
             C  S +C+P  W+CD + DC D SDE L   G  P  +  C  +   C +  CI K++ 
Sbjct: 2767 SCQGSRACVPRHWLCDGERDCPDGSDE-LSTAGCAP--NNTCDENAFMCHNKVCIPKQFV 2823

Query: 258  CDGDPDCKDGSDEV-NCPSRTCRPDQFECEDGSCIHGSR-QCNGIRDCVDGSDEV----N 311
            CD D DC DGSDE   C  R C  ++F C DG C+  ++ QC+G  DC D SDE      
Sbjct: 2824 CDHDDDCGDGSDESPQCGYRQCGTEEFSCADGRCLLNTQWQCDGDFDCPDHSDEAPLNPK 2883

Query: 312  CKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNN-GGCSHI 370
            CK+  Q      F C++G CI    +C+ + DC D SDE  + CHINECL     GCS  
Sbjct: 2884 CKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDCGDGSDE--RNCHINECLSKKVSGCSQD 2941

Query: 371  CKDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLKGGYKCECSRGYQM-- 427
            C+DL + Y+C C  GF+L D  KTC DIDEC +   CSQ CIN  G YKC C+ GY++  
Sbjct: 2942 CQDLPVSYKCKCWPGFQLKDDGKTCVDIDECSSGFPCSQQCINTYGTYKCLCTDGYEIQP 3001

Query: 428  DLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRNTVALDADIAAQKLFWAD 487
            D   G      +EP LI  +  +IRKI  +   Y  L + L N +A+D D   + ++W D
Sbjct: 3002 DNPNGCKSLSDEEPFLILADHHEIRKISTDGSNYTLLKQGLNNVIAIDFDYREEFIYWID 3061

Query: 488  LSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKR 547
             S+      +     G  +K++ N   P A+AVDW+ K +YW+D   + I V+ L+G   
Sbjct: 3062 SSRPNGSRINRMCLNGSDIKVVHNTAVPNALAVDWIGKNLYWSDTEKRIIEVSKLNGLYP 3121

Query: 548  KFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITL 607
              L +  L+ P  +++DP +G++YW D  E   I + GM+G ++  ++   I  P  +T+
Sbjct: 3122 TILVSKRLKFPRDLSLDPQAGYLYWIDCCEYPHIGRVGMDGTNQSVVIETKISRPMALTI 3181

Query: 608  DLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAV 667
            D +  RLYW D      S++D  G  R  V    + +   +ALT+FED +YW DG+ +++
Sbjct: 3182 DYVNRRLYWADENHIEFSNMD--GSHRHKVPN--QDIPGVIALTLFEDYIYWTDGKTKSL 3237

Query: 668  YGANKFTGSELATLVNNLNDAQDIIVYHELVQPS-GKNWCEEDMENGGCEYLCLPAPQIN 726
              A+K +G++  +L+ + +   DI VYH   QP   K+ C   + NGGC +LCL AP   
Sbjct: 3238 SRAHKTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCM--INNGGCSHLCLLAP--- 3292

Query: 727  DHSPKYTCSCPSGYNVEENGRDC 749
                 +TC+CP+ + +  + R C
Sbjct: 3293 --GKTHTCACPTNFYLAADNRTC 3313



 Score =  419 bits (1076), Expect = e-117
 Identities = 265/762 (34%), Positives = 363/762 (47%), Gaps = 87/762 (11%)

Query: 30   KAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRW 89
            K  C P +FQC N  CI   W+CD   DC D SDE+NC  +TC   DF+C NG CV SR+
Sbjct: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532

Query: 90   KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
             CDGD DC DGSDE    C   +C   +  C   + QCIP  W+CDG  DC  GEDE++C
Sbjct: 3533 WCDGDFDCADGSDE--RNCE-TSCSKDQFRCS--NGQCIPAKWKCDGHEDCKYGEDEKSC 3587

Query: 150  --GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSS-CI 206
               + TCS  E+ C+S  CIS +  CNG+ DC+DGSDE+DC    C   +F+C   + CI
Sbjct: 3588 EPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDCV-TECKEDQFRCKNKAHCI 3646

Query: 207  PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKD 266
            PI W+CD   DC D SDE  E C R   I   C A E  C +  C    W CDG+ DC D
Sbjct: 3647 PIRWLCDGIHDCVDGSDE--ENCERGGNI---CRADEFLCNNSLCKLHFWVCDGEDDCGD 3701

Query: 267  GSDEVN-------CPS---RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC---- 312
             SDE         CPS     CR ++       C+   + CNGI +C D SDE +C    
Sbjct: 3702 NSDEAPDMCVKFLCPSTRPHRCRNNRI------CLQSEQMCNGIDECGDNSDEDHCGGKL 3755

Query: 313  -KNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHIN------ECLVNNG 365
                  C    +F C + +CI +   C++  DC D SDE  + C I       E  VN  
Sbjct: 3756 TYKARPC-KKDEFACSNKKCIPMDLQCDRLDDCGDGSDE--QGCRIAPTEYTCEDNVNPC 3812

Query: 366  GCSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRG 424
            G    C  +     C C  GF+  +  + C D++EC   G CS  CIN++G YKC C + 
Sbjct: 3813 GDDAYCNQIKTSVFCRCKPGFQRNMKNRQCEDLNECLVFGTCSHQCINVEGSYKCVCDQN 3872

Query: 425  YQMDLATGVCKAVGKEPSLIF-TNRRDIRKIGL-------ERKEYIQLVEQLRNTVALDA 476
            +Q       C A G E  +++  N  DI  +G           + I  +E       +D 
Sbjct: 3873 FQE--RNNTCIAEGSEDQVLYIANDTDI--LGFIYPFNYSGDHQQISHIEHNSRITGMDV 3928

Query: 477  DIAAQKLFWA-DLSQKAIFSASIDDKVGRHVK---MIDNVYNPAAIAVDWVYKTIYWTD- 531
                  + W+   +   IF   I  +  R      +      P  IAVDWV   IYWTD 
Sbjct: 3929 YYQRDMIIWSTQFNPGGIFYKRIHGREKRQANSGLICPEFKRPRDIAVDWVAGNIYWTDH 3988

Query: 532  --------------AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGE 577
                          +   +I+V  L+G     L  +   EP +IAV+P  G +YW+  G+
Sbjct: 3989 SRMHWFSYYTTHWTSLRYSINVGQLNGPNCTRLLTNMAGEPYAIAVNPKRGMMYWTVVGD 4048

Query: 578  PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIV 637
             + IE+A M+G  RR LV  ++Q P G+ +D    R+YW D +L ++ SV  +G +  + 
Sbjct: 4049 HSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYFSERIYWADFELSIIGSVLYDGSNSVVS 4108

Query: 638  LKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHEL 697
            + S + L HP  + IFED +Y   G    V+   KF    +  L  N++  + +++ H  
Sbjct: 4109 VSSKQGLLHPHRIDIFEDYIYGA-GPKNGVFRVQKFGHGSVEYLALNIDKTKGVLISHRY 4167

Query: 698  VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSG 739
             Q    N C +      CE+LCL  P         TC CP G
Sbjct: 4168 KQLDLPNPCLD----LACEFLCLLNPS------GATCVCPEG 4199



 Score =  291 bits (746), Expect = 1e-78
 Identities = 145/353 (41%), Positives = 193/353 (54%), Gaps = 16/353 (4%)

Query: 31   AKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDE-KNCVKKTCAESDFVCNNGQCVPSRW 89
            + C  SQF+C   +CI   WKCD  +DC DGSDE  +C +  C    F C  G C    +
Sbjct: 3315 SNCTASQFRCKTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCALPAF 3374

Query: 90   KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
             CDG+ DC D SDE    C    C   +  C   + +CIPV+ RC+G++DC   EDE +C
Sbjct: 3375 ICDGENDCGDNSDEL--NCDTHVCLSGQFKC-TKNQKCIPVNLRCNGQDDCGDEEDERDC 3431

Query: 150  GNITCSPDEFTCSSGR-CISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPI 208
               +CSPD F C + + CIS+ +VC+   DC+D SDE +C   TCG HEFQC  ++CIP 
Sbjct: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEANCDKKTCGPHEFQCKNNNCIPD 3491

Query: 209  SWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGS 268
             W CD   DCSD SDE  E C  Q      C   +  C +G+C+  ++ CDGD DC DGS
Sbjct: 3492 HWRCDSQNDCSDNSDE--ENCKPQ-----TCTLKDFLCANGDCVSSRFWCDGDFDCADGS 3544

Query: 269  DEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRS 328
            DE NC + +C  DQF C +G CI    +C+G  DC  G DE +C+  +      ++ C S
Sbjct: 3545 DERNCET-SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICAS 3603

Query: 329  GECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECD 381
              CI  S  CN E DC D SDE   +C + EC  +   C +    + I + CD
Sbjct: 3604 DGCISASLKCNGEYDCADGSDE--MDC-VTECKEDQFRCKNKAHCIPIRWLCD 3653



 Score =  269 bits (687), Expect = 9e-72
 Identities = 136/345 (39%), Positives = 177/345 (51%), Gaps = 23/345 (6%)

Query: 32   KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQ-CVPSRWK 90
            +C+P +FQC  G C    + CDG+ DC D SDE NC    C    F C   Q C+P   +
Sbjct: 3356 RCQPGRFQCGTGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLR 3415

Query: 91   CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
            C+G  DC D  DE    C   +C      C   +  CI   W CD + DC    DE NC 
Sbjct: 3416 CNGQDDCGDEEDE--RDCPENSCSPDYFQCKT-TKHCISKLWVCDEDPDCADASDEANCD 3472

Query: 151  NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISW 210
              TC P EF C +  CI  ++ C+ Q+DCSD SDE +C P TC   +F C+   C+   +
Sbjct: 3473 KKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRF 3532

Query: 211  VCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
             CD D DC+D SDE    C       T C   + +C +G+CI  KW+CDG  DCK G DE
Sbjct: 3533 WCDGDFDCADGSDE--RNC------ETSCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDE 3584

Query: 271  VNC--PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRS 328
             +C   S TC   ++ C    CI  S +CNG  DC DGSDE++C  V +C    +F+C++
Sbjct: 3585 KSCEPASPTCSSREYICASDGCISASLKCNGEYDCADGSDEMDC--VTEC-KEDQFRCKN 3641

Query: 329  -GECIDISKVCNQEQDCRDWSDEPLKE-----CHINECLVNNGGC 367
               CI I  +C+   DC D SDE   E     C  +E L NN  C
Sbjct: 3642 KAHCIPIRWLCDGIHDCVDGSDEENCERGGNICRADEFLCNNSLC 3686



 Score =  226 bits (576), Expect = 7e-59
 Identities = 150/536 (27%), Positives = 244/536 (45%), Gaps = 72/536 (13%)

Query: 239 CPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDEV--NCPSRT---CRPDQFEC-EDGSCI 291
           C   E  C     C+ + W CDGDPDC D SDE    CP      C  +   C     C+
Sbjct: 32  CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91

Query: 292 HGSRQCNGIRDCVDGSDE-VNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
           H S+ CNG+ DC DG DE V+C+ +                                   
Sbjct: 92  HLSQLCNGVLDCPDGYDEGVHCQEL----------------------------------- 116

Query: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQI 409
                 ++ C   N  C + C  +     C C  GFE+  D ++C D DEC   G CSQ 
Sbjct: 117 ------LSNCQQLN--CQYKCTMVRNSTRCYCEDGFEITEDGRSCKDQDECAVYGTCSQT 168

Query: 410 CINLKGGYKCECSRGYQMDLATGVCKA----VGKEPSLIFTNRRDIRKIGLERKEYIQLV 465
           C N  G Y C C  GY M      CKA      + P L+  N   I    L   +   L 
Sbjct: 169 CRNTHGSYTCSCVEGYLMQPDNRSCKAKIEPTDRPPILLIANFETIEVFYLNGSKMATLS 228

Query: 466 EQLRNTV-ALDADIAAQKLFWADLSQKAIFSASID-DKVGR-----HVKMIDNVYNPAAI 518
               N +  LD       + W +  + +     I   K G       + ++ + +N   +
Sbjct: 229 SVNGNEIHTLDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQM 288

Query: 519 AVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEP 578
           A+DW+ + +Y+ D     I V   +G+    L + +L  P +IAVDP++G ++++D+G  
Sbjct: 289 AIDWLTRNLYFVDHVGDRIFVCNSNGSVCVTLIDLELHNPKAIAVDPIAGKLFFTDYGNV 348

Query: 579 AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVL 638
           AK+E+  M+G +R  ++ +  + P  + LDL+   +YW+D  L  +  VD  G++R  V+
Sbjct: 349 AKVERCDMDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVI 408

Query: 639 KSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELV 698
           +  + + H   +T+FED +Y  + +N  +   N+F G+++ +L+  + +A  I +Y +  
Sbjct: 409 QGRQ-VRHLYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLI-KIENAWGIRIYQKRT 466

Query: 699 QPSGKNW-CEEDMEN--GGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQR 751
           QP+ ++  CE D     GGC ++CL    ++      TC C +G+N+  +GR C+R
Sbjct: 467 QPTVRSHACEVDPYGMPGGCSHICL----LSSSYKTRTCRCRTGFNLGSDGRSCKR 518



 Score =  199 bits (506), Expect = 9e-51
 Identities = 118/371 (31%), Positives = 163/371 (43%), Gaps = 70/371 (18%)

Query: 110  MRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE-ENCGNITCSPDEFTCSSGRCIS 168
            +  C   +  C   + +CIP  W+CD  +DC  G DE ++C    C P  F C +G C  
Sbjct: 3314 LSNCTASQFRC--KTDKCIPFWWKCDTVDDCGDGSDEPDDCPEFRCQPGRFQCGTGLCAL 3371

Query: 169  RNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCS-TSSCIPIS------------------ 209
              F+C+G++DC D SDEL+C    C + +F+C+    CIP++                  
Sbjct: 3372 PAFICDGENDCGDNSDELNCDTHVCLSGQFKCTKNQKCIPVNLRCNGQDDCGDEEDERDC 3431

Query: 210  ----------------------WVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
                                  WVCD+D DC+D SDE+   C ++      C   E QC 
Sbjct: 3432 PENSCSPDYFQCKTTKHCISKLWVCDEDPDCADASDEA--NCDKK-----TCGPHEFQCK 3484

Query: 248  SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
            +  CI   WRCD   DC D SDE NC  +TC    F C +G C+     C+G  DC DGS
Sbjct: 3485 NNNCIPDHWRCDSQNDCSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGS 3544

Query: 308  DEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKE-----CHINECLV 362
            DE NC+         +F+C +G+CI     C+  +DC+   DE   E     C   E + 
Sbjct: 3545 DERNCET---SCSKDQFRCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYIC 3601

Query: 363  NNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDE--CQNPGICSQICINLKGGYKC- 419
             + GC  I   L    E DCA G + +D  T    D+  C+N   C  I     G + C 
Sbjct: 3602 ASDGC--ISASLKCNGEYDCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCV 3659

Query: 420  ------ECSRG 424
                   C RG
Sbjct: 3660 DGSDEENCERG 3670



 Score =  181 bits (459), Expect = 3e-45
 Identities = 126/371 (33%), Positives = 180/371 (48%), Gaps = 30/371 (8%)

Query: 396 DIDECQNPGICSQICINLKGGYK---CECSRGYQMDLATGVCKAVGKEPSLIFTNRRD-- 450
           ++D    PG CS IC+ L   YK   C C  G+ +      CK    E  L +   R   
Sbjct: 476 EVDPYGMPGGCSHICL-LSSSYKTRTCRCRTGFNLGSDGRSCKRPKNELFLFYGKGRPGI 534

Query: 451 IRKIGLERK---EYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVK 507
           +R + L  K   EY+  +E L N  ALD       +++AD +   I    ID    R   
Sbjct: 535 VRGMDLNTKIADEYMIPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG-TERETI 593

Query: 508 MIDNVYNPAAIAVDWVYKTIYWT-DAASKTISVATLD--GTKRKFLFNSDLREPASIAVD 564
           + D++ N   IAVDW+   +YWT D   KTI+VA L+     RK L   ++  P  I VD
Sbjct: 594 LKDDLDNVEGIAVDWIGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGEMSHPRGIVVD 653

Query: 565 PLSGFVYWSDWGEP------AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLD 618
           P++G++YW+DW E        +IEKA M+GF+R+  VT+ + WPNG+TLD   + LYW D
Sbjct: 654 PVNGWMYWTDWEEDEIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCD 713

Query: 619 SKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSEL 678
           +    +  V LNG  R+IV    E L HP  L+   + V+W D  N +++  +  T SE+
Sbjct: 714 AYYDHIEKVFLNGTHRKIVYSGRE-LNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT-SEV 771

Query: 679 ATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPS 738
             L +       + +Y    Q  G N C   + NGGC  LCL  P          C+C  
Sbjct: 772 TLLRHERPPLFGLQIYDPRKQ-QGDNMCR--VNNGGCSTLCLAIP------GGRVCACAD 822

Query: 739 GYNVEENGRDC 749
              ++ENG  C
Sbjct: 823 NQLLDENGTTC 833



 Score =  171 bits (434), Expect = 2e-42
 Identities = 106/321 (33%), Positives = 147/321 (45%), Gaps = 27/321 (8%)

Query: 113  CRIHEISCGAHST------QCIPVSWRCDGENDCDSGEDEE--NCGNITCSPDEFTCSSG 164
            C     SC A+S       +CI     CDG   C    DE+   C N +C      C + 
Sbjct: 2503 CVTKNSSCNAYSEFECGNGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNR 2562

Query: 165  RCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE 224
            RCI    +C+G++DC D SDELDC   TC   EF+C+  +CIP S  C+ + DC+D SDE
Sbjct: 2563 RCIPHGKLCDGENDCGDNSDELDCKVSTCATVEFRCADGTCIPRSARCNQNIDCADASDE 2622

Query: 225  SLEQCGRQPVIH----TKCPASEIQCGSGE-CIHKKWRCDGDPDCKDGSDEVNCP---SR 276
              + C      H           I+C S   C+   W CDG  DC D SDE+ CP     
Sbjct: 2623 --KNCNNTDCTHFYKLGVKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKH 2680

Query: 277  TCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISK 336
             C  + F C  G CI  +  C+G +DC DG DE +C   +      +F C + +CI    
Sbjct: 2681 KCEENYFSCPSGRCILNTWICDGQKDCEDGRDEFHC---DSSCSWNQFACSAQKCISKHW 2737

Query: 337  VCNQEQDCRDWSDEPLKECHINECLVNNGGC--SHIC--KDLVIGYECDCAAGFELIDRK 392
            +C+ E DC D  DE    C    C  +   C  S  C  +  +   E DC  G + +   
Sbjct: 2738 ICDGEDDCGDGLDESDSICGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDELSTA 2797

Query: 393  TCGDIDEC-QNPGIC-SQICI 411
             C   + C +N  +C +++CI
Sbjct: 2798 GCAPNNTCDENAFMCHNKVCI 2818



 Score =  163 bits (412), Expect = 7e-40
 Identities = 117/413 (28%), Positives = 194/413 (46%), Gaps = 28/413 (6%)

Query: 347  WSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQ-NPGI 405
            W+D+ L +  +  C   +G    I ++   G         ++ D++     + CQ N G 
Sbjct: 1792 WADQNLAQ--LGTCSKRDGRNPTILRNKTSG-----VVHMKVYDKEAQQGSNSCQLNNGG 1844

Query: 406  CSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQL 464
            CSQ+C+      + C C+ GY +      C+ +  E  L+++    IR I LE  + +  
Sbjct: 1845 CSQLCLPTSETTRTCMCTVGYYLQKNRMSCQGI--ESFLMYSVHEGIRGIPLEPSDKMDA 1902

Query: 465  VEQLRNT---VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVD 521
            +  +  T   V +D       ++W D+    I  A  D      + + + +     IAVD
Sbjct: 1903 LMPISGTSFAVGIDFHAENDTIYWTDMGFNKISRAKRDQTWKEDI-ITNGLGRVEGIAVD 1961

Query: 522  WVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKI 581
            W+   IYWTD     I VA L+G+ R  + +  L +P SIAV P  G ++W++WG+   I
Sbjct: 1962 WIAGNIYWTDHGFNLIEVARLNGSFRYVIISQGLDQPRSIAVHPEKGLLFWTEWGQMPCI 2021

Query: 582  EKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDL-NGQDRRIVLKS 640
             KA ++G ++  LV+  I WPNGI++D  +++LYW D++   +  +DL  G +R +VL  
Sbjct: 2022 GKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYWCDARTDKIERIDLETGGNREMVLSG 2081

Query: 641  LEFLAHPLALTIFEDRVYWID--GENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELV 698
                    ++ +F   +YW D    N +V   +K   +E  T+   L      +     V
Sbjct: 2082 SN--VDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDATETITMRTGLGVNLKEVKIFNRV 2139

Query: 699  QPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQR 751
            +  G N C  D  NGGC+ LCL        + + TC+C  GY + E+G  C R
Sbjct: 2140 REKGTNVCARD--NGGCKQLCL-----YRGNSRRTCACAHGY-LAEDGVTCLR 2184



 Score =  145 bits (366), Expect = 2e-34
 Identities = 73/175 (41%), Positives = 100/175 (57%), Gaps = 13/175 (7%)

Query: 23   GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK--NCVKKT------CAE 74
            G+   G    C  +QF+C++GRCI   W CDGD DC D SDE   NC K+       C  
Sbjct: 996  GSDEVGCVHSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNG 1055

Query: 75   SDFVCN-NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHST-QCIPVSW 132
            ++F C+ +G CVP  W+CDG+ DCEDGSDE      +R C  H+      ST +CI  +W
Sbjct: 1056 NEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCD-HKTKFSCWSTGRCINKAW 1114

Query: 133  RCDGENDCDSGEDEENCGNITCSPDEFTCSSGR--CISRNFVCNGQDDCSDGSDE 185
             CDG+ DC+   DE++C +  C P +  C++    C+    +CNG+ DC DGSDE
Sbjct: 1115 VCDGDIDCEDQSDEDDCDSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169



 Score =  135 bits (340), Expect = 2e-31
 Identities = 69/185 (37%), Positives = 91/185 (49%), Gaps = 9/185 (4%)

Query: 187  DCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQC 246
            +  P  C A EF+C    CI   W CD D DC D SDE    C      +  CP  + +C
Sbjct: 839  EALPHICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNC-----FNHSCPDDQFKC 893

Query: 247  GSGECIHKKWRCDGDPDCKDGSDEVN--CPSRTCRPDQFECEDGSCIHGSRQCNGIRDCV 304
             +  CI K+W CDG  DC    DE N  C +RTC+ DQF C +G CI  +  C+   DC 
Sbjct: 894  QNNRCIPKRWLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCG 953

Query: 305  DGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEP--LKECHINECLV 362
            D +DE+       C    +F C+SG CI     C+ + DC D SDE   +  C  N+   
Sbjct: 954  DQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVHSCFDNQFRC 1013

Query: 363  NNGGC 367
            ++G C
Sbjct: 1014 SSGRC 1018



 Score =  134 bits (337), Expect = 4e-31
 Identities = 93/356 (26%), Positives = 168/356 (47%), Gaps = 23/356 (6%)

Query: 404  GICSQIC-INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
            G CS +C IN      C C    ++      C  + K   L++  R +IR + ++   + 
Sbjct: 1538 GPCSHMCLINHNRSAACACPHLMKLSSDKKTCYEMKK--FLLYARRSEIRGVDIDNPYFN 1595

Query: 463  QL----VEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAI 518
             +    V  + +   +D D + ++L+W D+  + I  A I+   G    +  ++ +   +
Sbjct: 1596 FITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTIKRAFING-TGLETVISRDIQSIRGL 1654

Query: 519  AVDWVYKTIYWTDAA--SKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG 576
            AVDWV + +YW  +      I+VA LDG+ +  + +  + +P  +A  P+ G +YW+D  
Sbjct: 1655 AVDWVSRNLYWISSEFDETQINVARLDGSLKTSIIHG-IDKPQCLAAHPVRGKLYWTDGN 1713

Query: 577  EPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRI 636
                I  A M+G + + L     + P G+++D ++++LYW+ S    ++  +L+G +  +
Sbjct: 1714 T---INMANMDGSNSKILFQNQKE-PVGLSIDYVENKLYWISSGNGTINRCNLDGGNLEV 1769

Query: 637  VLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHE 696
            +    E L    ALTI + +++W D     +   +K  G     L N  +    + VY +
Sbjct: 1770 IESMKEELTKATALTIMDKKLWWADQNLAQLGTCSKRDGRNPTILRNKTSGVVHMKVYDK 1829

Query: 697  LVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRI 752
              Q  G N C+  + NGGC  LCLP  +        TC C  GY +++N   CQ I
Sbjct: 1830 EAQ-QGSNSCQ--LNNGGCSQLCLPTSETT-----RTCMCTVGYYLQKNRMSCQGI 1877



 Score =  108 bits (270), Expect = 2e-23
 Identities = 90/380 (23%), Positives = 170/380 (44%), Gaps = 39/380 (10%)

Query: 404  GICSQICINLKGGYK-CECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYI 462
            G C Q+C+      + C C+ GY   LA      +  E  L+++ R  ++ I L  +  +
Sbjct: 2152 GGCKQLCLYRGNSRRTCACAHGY---LAEDGVTCLRHEGYLLYSGRTILKSIHLSDETNL 2208

Query: 463  -------QLVEQLRNTVALDADI-----AAQKLFWADLSQKAIFSASIDDKVGRHVKMID 510
                   +     +N +AL  D         ++F++D     I    I D       +++
Sbjct: 2209 NSPIRPYENPRYFKNVIALAFDYNQRRKGTNRIFYSDAHFGNI--QLIKDNWEDRQVIVE 2266

Query: 511  NVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK------RKFLFNSDLREPASIAVD 564
            NV +   +A    + T+YWT + + +I+  T+D T+         +  S+   P  +A+D
Sbjct: 2267 NVGSVEGLAYHRAWDTLYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALD 2326

Query: 565  PLSGFVYWSDWGEP-AKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHM 623
                 ++W++W E    I ++ + G + + +V+ DI  PNG+T+D    +LY+ D  L  
Sbjct: 2327 ECQNLMFWTNWNEQHPSIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGK 2386

Query: 624  LSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVN 683
            +   + +G  R +++KS       L+L ++++ ++W D    A+  +NK+TG +   L +
Sbjct: 2387 IERCEYDGSQRHVIVKSGP--GTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRS 2444

Query: 684  NLNDAQDIIVYHELVQPSGKNWCEED---MENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
            ++      I+       +  N CE     + NGGC  LCL  P     + +  CSC    
Sbjct: 2445 DIPHQPMGII----AVANDTNSCELSPCALLNGGCHDLCLLTP-----NGRVNCSCRGDR 2495

Query: 741  NVEENGRDCQRINVTTAVSE 760
             + E+ R   + +   A SE
Sbjct: 2496 ILLEDNRCVTKNSSCNAYSE 2515



 Score =  103 bits (257), Expect = 7e-22
 Identities = 67/210 (31%), Positives = 93/210 (44%), Gaps = 30/210 (14%)

Query: 21   ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEK-NCVKKTCAESDFVC 79
            E    G      C+ + F C N  CI   + CD D+DC DGSDE   C  + C   +F C
Sbjct: 2793 ELSTAGCAPNNTCDENAFMCHNKVCIPKQFVCDHDDDCGDGSDESPQCGYRQCGTEEFSC 2852

Query: 80   NNGQC-VPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGA-----HSTQCIPVSWR 133
             +G+C + ++W+CDGD DC D SDE+P       C+  E SC +      + +CIP    
Sbjct: 2853 ADGRCLLNTQWQCDGDFDCPDHSDEAPLN---PKCKSAEQSCNSSFFMCKNGRCIPSGGL 2909

Query: 134  CDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSD--GSDELDCAPP 191
            CD ++DC  G DE N            C    C+S+  V     DC D   S +  C P 
Sbjct: 2910 CDNKDDCGDGSDERN------------CHINECLSKK-VSGCSQDCQDLPVSYKCKCWP- 2955

Query: 192  TCGAHEFQCSTSSCIPISWVCDDDADCSDQ 221
                 + +    +C+ I   C     CS Q
Sbjct: 2956 ---GFQLKDDGKTCVDID-ECSSGFPCSQQ 2981



 Score = 73.9 bits (180), Expect = 6e-13
 Identities = 54/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)

Query: 69  KKTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDES----PEQCHMRTCRIHEISCGAH 123
           ++ C   +F+C++   CV   W CDGDPDC D SDES    PE+  ++ C ++ I+C   
Sbjct: 29  QQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIK-CPLNHIAC-LG 86

Query: 124 STQCIPVSWRCDGENDCDSGEDE--------ENCGNITCSPDEFTCSSGRCISRNFVCNG 175
           + +C+ +S  C+G  DC  G DE         NC  + C   ++ C+  R  +R +  +G
Sbjct: 87  TNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNC---QYKCTMVRNSTRCYCEDG 143

Query: 176 QDDCSDG---SDELDCA-----PPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLE 227
            +   DG    D+ +CA       TC  +     T SC+    +  D+  C       +E
Sbjct: 144 FEITEDGRSCKDQDECAVYGTCSQTC-RNTHGSYTCSCVEGYLMQPDNRSCK----AKIE 198

Query: 228 QCGRQPVI 235
              R P++
Sbjct: 199 PTDRPPIL 206



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 40/124 (32%), Positives = 56/124 (45%), Gaps = 9/124 (7%)

Query: 33  CEPSQFQCTNG-RCITLLWKCDGDEDCVDGSDEK--NC---VKKTCAESDFVC-NNGQCV 85
           C+P +F C +   C++  W CDGD DC D SDE    C   V+  C  +   C    +CV
Sbjct: 32  CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91

Query: 86  PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
                C+G  DC DG DE    C        +++C    T  +  S RC  E+  +  ED
Sbjct: 92  HLSQLCNGVLDCPDGYDEG-VHCQELLSNCQQLNCQYKCTM-VRNSTRCYCEDGFEITED 149

Query: 146 EENC 149
             +C
Sbjct: 150 GRSC 153



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 41/144 (28%), Positives = 60/144 (41%), Gaps = 36/144 (25%)

Query: 23   GATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC----VKKTCAES--- 75
            G   T +   C+  +F C+N +CI +  +CD  +DC DGSDE+ C     + TC ++   
Sbjct: 3752 GGKLTYKARPCKKDEFACSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNP 3811

Query: 76   ---DFVCNN------GQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQ 126
               D  CN        +C P   +   +  CED          +  C +     G  S Q
Sbjct: 3812 CGDDAYCNQIKTSVFCRCKPGFQRNMKNRQCED----------LNECLVF----GTCSHQ 3857

Query: 127  CIPV--SWRCDGENDCDSGEDEEN 148
            CI V  S++C     CD    E N
Sbjct: 3858 CINVEGSYKC----VCDQNFQERN 3877



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 20/47 (42%), Positives = 26/47 (55%), Gaps = 3/47 (6%)

Query: 350 EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRK--TC 394
           +P K+   N C VNNGGCS +C  +  G  C CA   +L+D    TC
Sbjct: 788 DPRKQQGDNMCRVNNGGCSTLCLAIPGGRVCACADN-QLLDENGTTC 833



 Score = 31.2 bits (69), Expect = 4.2
 Identities = 14/49 (28%), Positives = 23/49 (46%), Gaps = 6/49 (12%)

Query: 706  CEE-DMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
            C+E  + NGGC   C   P          CSCP G  + ++ + C+ ++
Sbjct: 1173 CDECSLNNGGCSNHCSVVP-----GRGIVCSCPEGLQLNKDNKTCEIVD 1216


>gi|4507157 sortilin-related receptor containing LDLR class A repeats
            preproprotein [Homo sapiens]
          Length = 2214

 Score =  252 bits (643), Expect = 1e-66
 Identities = 148/407 (36%), Positives = 192/407 (47%), Gaps = 54/407 (13%)

Query: 32   KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
            +C   ++ C++G CI   W CDGD DC D SDE NC  +  TC  S+F C NG C+P RW
Sbjct: 1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRW 1216

Query: 90   KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
             CDGD DC+DGSDE P  C  + C       G     CIP S  CDG  DC  G DE++C
Sbjct: 1217 ACDGDTDCQDGSDEDPVNCE-KKCNGFRCPNGT----CIPSSKHCDGLRDCSDGSDEQHC 1271

Query: 150  GNITCSPDEFTCSS-GRCISRNFVCNGQDDCSDGSDE----LDCAP-----PTCGAHEFQ 199
              +     +F C +  +C+  + VC+G   C DGSDE      C+        C    FQ
Sbjct: 1272 EPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQ 1331

Query: 200  CSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPA-SEIQCGSGECIHKKWRC 258
            C    CI + W CD   DC D SDE+   C   P     C    + +C +G CI  +W+C
Sbjct: 1332 CQNGVCISLIWKCDGMDDCGDYSDEA--NC-ENPTEAPNCSRYFQFRCENGHCIPNRWKC 1388

Query: 259  DGDPDCKDGSDEVNC------------PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDG 306
            D + DC D SDE +C            PS TC P+ + C  G+C+  +  C+G RDC DG
Sbjct: 1389 DRENDCGDWSDEKDCGDSHILPFSTPGPS-TCLPNYYRCSSGTCVMDTWVCDGYRDCADG 1447

Query: 307  SDEVNC---KNVNQCLGPG--------KFKCRSGE-CIDISKVCNQEQDCRDWSDEPLKE 354
            SDE  C    NV     P         +F+C   + CI   K C+  QDC+D  DE    
Sbjct: 1448 SDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCP 1507

Query: 355  CHIN-ECLVNNGGCSHICKDLVIGYECDCAAGF----ELIDRKTCGD 396
             H    C+     C      +V+   CD   GF    +  D K C D
Sbjct: 1508 THSTLTCMSREFQCEDGEACIVLSERCD---GFLDCSDESDEKACSD 1551



 Score =  251 bits (641), Expect = 2e-66
 Identities = 143/381 (37%), Positives = 182/381 (47%), Gaps = 71/381 (18%)

Query: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTC-AESDFVC-NNGQCVPSRWK 90
            C  +Q++C+NG CI  +W CD D DC D SDE+NC    C  ++ F C  +G C+P  +K
Sbjct: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137

Query: 91   CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
            CD + DC D SDES   C M  CR  E +C   S  CI  SW CDG+NDC    DE NC 
Sbjct: 1138 CDLEDDCGDNSDES--HCEMHQCRSDEYNCS--SGMCIRSSWVCDGDNDCRDWSDEANCT 1193

Query: 151  NI--TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCI 206
             I  TC    F C +G CI + + C+G  DC DGSDE  ++C     G   F+C   +CI
Sbjct: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---FRCPNGTCI 1250

Query: 207  PISWVCDDDADCSDQSDE------------------------------------------ 224
            P S  CD   DCSD SDE                                          
Sbjct: 1251 PSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDA 1310

Query: 225  SLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPD--- 281
            +   C + P  H  C     QC +G CI   W+CDG  DC D SDE NC + T  P+   
Sbjct: 1311 AFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSR 1370

Query: 282  --QFECEDGSCIHGSRQCNGIRDCVDGSDEVNC----------KNVNQCLGPGKFKCRSG 329
              QF CE+G CI    +C+   DC D SDE +C             + CL P  ++C SG
Sbjct: 1371 YFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCL-PNYYRCSSG 1429

Query: 330  ECIDISKVCNQEQDCRDWSDE 350
             C+  + VC+  +DC D SDE
Sbjct: 1430 TCVMDTWVCDGYRDCADGSDE 1450



 Score =  230 bits (586), Expect = 5e-60
 Identities = 137/381 (35%), Positives = 175/381 (45%), Gaps = 81/381 (21%)

Query: 57   DCVDGSDEKN--CVKK--TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRT 112
            DC  G   KN  CVK+  TC  + + C+NG C+ S W CD D DC D SDE    C    
Sbjct: 1059 DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE--RNCPTTI 1116

Query: 113  CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFV 172
            C +        S  CIP+S++CD E+DC    DE +C    C  DE+ CSSG CI  ++V
Sbjct: 1117 CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWV 1176

Query: 173  CNGQDDCSDGSDELDCAP--PTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCG 230
            C+G +DC D SDE +C     TC A  FQC    CIP  W CD D DC D SDE    C 
Sbjct: 1177 CDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE 1236

Query: 231  RQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP---------------- 274
            +      KC  +  +C +G CI     CDG  DC DGSDE +C                 
Sbjct: 1237 K------KC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQ 1288

Query: 275  ---------------------------------SRTCRPDQFECEDGSCIHGSRQCNGIR 301
                                              + C    F+C++G CI    +C+G+ 
Sbjct: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348

Query: 302  DCVDGSDEVNCKNVNQ---CLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC--- 355
            DC D SDE NC+N  +   C    +F+C +G CI     C++E DC DWSDE  K+C   
Sbjct: 1349 DCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE--KDCGDS 1406

Query: 356  HI--------NECLVNNGGCS 368
            HI        + CL N   CS
Sbjct: 1407 HILPFSTPGPSTCLPNYYRCS 1427



 Score =  154 bits (388), Expect = 4e-37
 Identities = 94/328 (28%), Positives = 159/328 (48%), Gaps = 26/328 (7%)

Query: 434  CKAVGKEPSLIFTNRRDIRKIGLERKEYIQL-VEQLRNTVALDADIAAQKLFWADLSQKA 492
            C    +   +++  R+ I +  L      QL +  LR  VALD D     L+W+DL+   
Sbjct: 752  CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811

Query: 493  IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFN 552
            I    ++   G+ V +   +    A+A + + + +YW DA  K I VA  DG  R  + N
Sbjct: 812  IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871

Query: 553  SD-LREPASIAVDPLSGFVYWSDWGE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
            S  L  P ++ + P  G ++W+DWG+    I ++ M+G     LV+ D++WPNGI++D  
Sbjct: 872  SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929

Query: 611  KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGA 670
               +YW D+ L  +  +  +GQ R ++L +   L HP A+ +F++ +YW D    +++ A
Sbjct: 930  DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHPYAIAVFKNEIYWDDWSQLSIFRA 986

Query: 671  NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDH-- 728
            +K++GS++  L N L    D+ ++++     GKN          C  LCLP    +    
Sbjct: 987  SKYSGSQMEILANQLTGLMDMKIFYK-----GKNTGSNACVPRPCSLLCLPKANNSRSCR 1041

Query: 729  -----------SPKYTCSCPSGYNVEEN 745
                       S    C CP GY ++ N
Sbjct: 1042 CPEDVSSSVLPSGDLMCDCPQGYQLKNN 1069



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 5/106 (4%)

Query: 32   KCEPSQFQCTNGRCITLLWK-CDGDEDCVDGSDEKNCVKK---TCAESDFVCNNGQ-CVP 86
            +C+  +F+C   +     WK CDG +DC DG DE NC      TC   +F C +G+ C+ 
Sbjct: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIV 1529

Query: 87   SRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSW 132
               +CDG  DC D SDE      +   ++  +   A  +  + ++W
Sbjct: 1530 LSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTW 1575


>gi|119709832 low density lipoprotein receptor-related protein 5
           [Homo sapiens]
          Length = 1615

 Score =  246 bits (629), Expect = 5e-65
 Identities = 126/314 (40%), Positives = 193/314 (61%), Gaps = 13/314 (4%)

Query: 441 PSLIFTNRRDIRKI--GLERKEYIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASI 498
           P L+F NRRD+R +  G  + E   +V  L +  A+D   +   ++W D+S++AI    +
Sbjct: 33  PLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTDVSEEAIKQTYL 92

Query: 499 DDKVGRHVK--MIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLR 556
           + + G  V+  +I  + +P  +A DWV K +YWTD+ +  I VA L+GT RK LF  DL 
Sbjct: 93  N-QTGAAVQNVVISGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGTSRKVLFWQDLD 151

Query: 557 EPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYW 616
           +P +IA+DP  G++YW+DWGE  +IE+AGM+G  R+ +V +DI WPNG+T+DL + +LYW
Sbjct: 152 QPRAIALDPAHGYMYWTDWGETPRIERAGMDGSTRKIIVDSDIYWPNGLTIDLEEQKLYW 211

Query: 617 LDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGS 676
            D+KL  +   +L+G  R+ V++    L HP ALT+  D +YW D +  +++  NK TG 
Sbjct: 212 ADAKLSFIHRANLDGSFRQKVVEG--SLTHPFALTLSGDTLYWTDWQTRSIHACNKRTGG 269

Query: 677 ELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSC 736
           +   +++ L    DI V  +  QP     CEED  NGGC +LCL +P      P YTC+C
Sbjct: 270 KRKEILSALYSPMDIQVLSQERQPFFHTRCEED--NGGCSHLCLLSPS----EPFYTCAC 323

Query: 737 PSGYNVEENGRDCQ 750
           P+G  +++NGR C+
Sbjct: 324 PTGVQLQDNGRTCK 337



 Score =  212 bits (539), Expect = 1e-54
 Identities = 127/394 (32%), Positives = 203/394 (51%), Gaps = 34/394 (8%)

Query: 401 QNPGICSQICINLKGG--YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLER 458
           ++ G CS +C+       Y C C  G Q+      CKA G E  L+   R D+R+I L+ 
Sbjct: 301 EDNGGCSHLCLLSPSEPFYTCACPTGVQLQDNGRTCKA-GAEEVLLLARRTDLRRISLDT 359

Query: 459 KEYIQLVEQ---LRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNP 515
            ++  +V Q   +R+ +A+D D     ++W D   +AI  A +D   G    +   + +P
Sbjct: 360 PDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAIRRAYLDGS-GAQTLVNTEINDP 418

Query: 516 AAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDW 575
             IAVDWV + +YWTD  +  I V  L+GT RK L + DL EP +IA+ P+ G +YW+DW
Sbjct: 419 DGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSEDLDEPRAIALHPVMGLMYWTDW 478

Query: 576 GEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRR 635
           GE  KIE A ++G +RR LV A + WPNG+ LDL + +LYW D+K   +  ++++G  RR
Sbjct: 479 GENPKIECANLDGQERRVLVNASLGWPNGLALDLQEGKLYWGDAKTDKIEVINVDGTKRR 538

Query: 636 IVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYH 695
            +L+  + L H    T+  D +YW D +  ++   +K   S    +++ L D   +   +
Sbjct: 539 TLLE--DKLPHIFGFTLLGDFIYWTDWQRRSIERVHKVKASR-DVIIDQLPDLMGLKAVN 595

Query: 696 ELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC------ 749
            + +  G N C +   NGGC +LC   P    H+ +  C CP G  +  + + C      
Sbjct: 596 -VAKVVGTNPCAD--RNGGCSHLCFFTP----HATR--CGCPIGLELLSDMKTCIVPEAF 646

Query: 750 ---------QRINVTTAVSEVSVPPKGTSAAWAI 774
                     RI++ T  ++V++P  G   A A+
Sbjct: 647 LVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680



 Score =  189 bits (480), Expect = 9e-48
 Identities = 122/395 (30%), Positives = 182/395 (46%), Gaps = 59/395 (14%)

Query: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
           N C   NGGCSH+C        C C  G EL+ D KTC                      
Sbjct: 603 NPCADRNGGCSHLCFFTPHATRCGCPIGLELLSDMKTC---------------------- 640

Query: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLE--RKEYIQLVEQLRNTVAL 474
                               +  E  L+FT+R  I +I LE    +    +  ++   AL
Sbjct: 641 --------------------IVPEAFLVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680

Query: 475 DADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS 534
           D D++   ++W D+S K I  A ++     HV      Y P  +AVDW+ K +YW D  +
Sbjct: 681 DFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVVEFGLDY-PEGMAVDWMGKNLYWADTGT 739

Query: 535 KTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPL 594
             I VA LDG  R+ L   DL  P S+A+DP  G++YW++WG   +I +A M+G +   L
Sbjct: 740 NRIEVARLDGQFRQVLVWRDLDNPRSLALDPTKGYIYWTEWGGKPRIVRAFMDGTNCMTL 799

Query: 595 VTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFE 654
           V   +   N +T+D    RLYW D   +M+ S ++ GQ+R ++    + L HP  LT + 
Sbjct: 800 VD-KVGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVI---ADDLPHPFGLTQYS 855

Query: 655 DRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGG 714
           D +YW D    ++  A+K +G     +  +L+   DI+V+H   Q  G N C  +  NG 
Sbjct: 856 DYIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQ-DGLNDCMHN--NGQ 912

Query: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
           C  LCL  P        + C C S Y ++ + R+C
Sbjct: 913 CGQLCLAIP------GGHRCGCASHYTLDPSSRNC 941



 Score =  135 bits (340), Expect = 2e-31
 Identities = 95/351 (27%), Positives = 172/351 (49%), Gaps = 22/351 (6%)

Query: 397  IDECQ-NPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
            +++C  N G C Q+C+ + GG++C C+  Y +D ++  C        L+F+ +  I ++ 
Sbjct: 903  LNDCMHNNGQCGQLCLAIPGGHRCGCASHYTLDPSSRNCSP--PTTFLLFSQKSAISRMI 960

Query: 456  LERKEYIQLV---EQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512
             + +    L+     LRN  A+D D   + ++W D  Q  I  A  D      +  +   
Sbjct: 961  PDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYWVDGRQN-IKRAKDDGTQPFVLTSLSQG 1019

Query: 513  YNPAA----IAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSG 568
             NP      +++D   +T++WT  A+ TI+V  L G     +   D  +P +I V+   G
Sbjct: 1020 QNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGEAMGVVLRGDRDKPRAIVVNAERG 1079

Query: 569  FVYWSDWGE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSV 627
            ++Y+++  +  AKIE+A ++G +R  L T  +  P  + +D    +L+W+D+ L  + S 
Sbjct: 1080 YLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVDADLKRIESC 1139

Query: 628  DLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLND 687
            DL+G + R+ L+    +  PL LTI    +YWID + + +    K TG +   +   +  
Sbjct: 1140 DLSGAN-RLTLEDAN-IVQPLGLTILGKHLYWIDRQQQMIERVEKTTGDKRTRIQGRVAH 1197

Query: 688  AQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
               I    E+ ++    + C  D  NGGC ++C+      D +P+  CSCP
Sbjct: 1198 LTGIHAVEEVSLEEFSAHPCARD--NGGCSHICIAK---GDGTPR--CSCP 1241



 Score =  119 bits (299), Expect = 9e-27
 Identities = 56/126 (44%), Positives = 76/126 (60%), Gaps = 12/126 (9%)

Query: 190  PPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG 247
            PPTC   +F C+T    CIP +W CD   +C DQSDE  E C   PV    C A++  C 
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDE--EGC---PV----CSAAQFPCA 1306

Query: 248  SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGS 307
             G+C+  + RCDG+ DC+D SDE +C +  C P+QF C  G C+   +QC+   DC+DGS
Sbjct: 1307 RGQCVDLRLRCDGEADCQDRSDEADCDA-ICLPNQFRCASGQCVLIKQQCDSFPDCIDGS 1365

Query: 308  DEVNCK 313
            DE+ C+
Sbjct: 1366 DELMCE 1371



 Score =  105 bits (263), Expect = 1e-22
 Identities = 55/133 (41%), Positives = 72/133 (54%), Gaps = 11/133 (8%)

Query: 224  ESLEQCGRQPVIHTKCPASEIQCGSGE--CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPD 281
            ++L  CG  P     C   +  C +GE  CI   WRCDG P+C D SDE  CP   C   
Sbjct: 1248 QNLLTCGEPPT----CSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAA 1301

Query: 282  QFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQE 341
            QF C  G C+    +C+G  DC D SDE +C  +  CL P +F+C SG+C+ I + C+  
Sbjct: 1302 QFPCARGQCVDLRLRCDGEADCQDRSDEADCDAI--CL-PNQFRCASGQCVLIKQQCDSF 1358

Query: 342  QDCRDWSDEPLKE 354
             DC D SDE + E
Sbjct: 1359 PDCIDGSDELMCE 1371



 Score =  105 bits (262), Expect = 2e-22
 Identities = 47/122 (38%), Positives = 66/122 (54%), Gaps = 3/122 (2%)

Query: 112  TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNF 171
            TC   + +C      CIP +WRCDG  +CD   DEE C    CS  +F C+ G+C+    
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCP--VCSAAQFPCARGQCVDLRL 1315

Query: 172  VCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGR 231
             C+G+ DC D SDE DC    C  ++F+C++  C+ I   CD   DC D SDE + +  +
Sbjct: 1316 RCDGEADCQDRSDEADC-DAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCEITK 1374

Query: 232  QP 233
             P
Sbjct: 1375 PP 1376



 Score = 98.2 bits (243), Expect = 3e-20
 Identities = 53/133 (39%), Positives = 68/133 (51%), Gaps = 10/133 (7%)

Query: 28   GRKAKCEPSQFQCTNGR--CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCV 85
            G    C P QF C  G   CI   W+CDG  +C D SDE+ C    C+ + F C  GQCV
Sbjct: 1254 GEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC--PVCSAAQFPCARGQCV 1311

Query: 86   PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
              R +CDG+ DC+D SDE+   C    C  ++  C   S QC+ +  +CD   DC  G D
Sbjct: 1312 DLRLRCDGEADCQDRSDEA--DCD-AICLPNQFRCA--SGQCVLIKQQCDSFPDCIDGSD 1366

Query: 146  EENCGNITCSPDE 158
            E  C  IT  P +
Sbjct: 1367 ELMC-EITKPPSD 1378



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 19/51 (37%), Positives = 24/51 (47%), Gaps = 2/51 (3%)

Query: 352  LKECHINECLVNNGGCSHICKDLVIGY-ECDCAAGFELIDR-KTCGDIDEC 400
            L+E   + C  +NGGCSHIC     G   C C     L+    TCG+   C
Sbjct: 1209 LEEFSAHPCARDNGGCSHICIAKGDGTPRCSCPVHLVLLQNLLTCGEPPTC 1259


>gi|148727288 low density lipoprotein receptor-related protein 6
           [Homo sapiens]
          Length = 1613

 Score =  242 bits (617), Expect = 1e-63
 Identities = 119/324 (36%), Positives = 193/324 (59%), Gaps = 10/324 (3%)

Query: 429 LATGVCKAVGKEPSLIFTNRRDIRKIGLE--RKEYIQLVEQLRNTVALDADIAAQKLFWA 486
           LA   C  +   P L++ NRRD+R +     ++    +V  L +  A+D   +   ++W+
Sbjct: 9   LACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWS 68

Query: 487 DLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTK 546
           D+S++AI     +        ++  + +P  +A DW+ + +YWTD+ +  I V+ LDG+ 
Sbjct: 69  DVSEEAIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSL 128

Query: 547 RKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGIT 606
           RK LF  +L +P +IA+DP SGF+YW+DWGE  KIE+AGM+G  R  ++ ++I WPNG+T
Sbjct: 129 RKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSEIYWPNGLT 188

Query: 607 LDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEA 666
           LD  + +LYW D+KL+ +   +L+G +R+ V+K    L HP ALT+FED +YW D    +
Sbjct: 189 LDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKG--SLPHPFALTLFEDILYWTDWSTHS 246

Query: 667 VYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQIN 726
           +   NK+TG  L  + +++    DI  + +  QP+  N C   ++NGGC +LCL +P   
Sbjct: 247 ILACNKYTGEGLREIHSDIFSPMDIHAFSQQRQPNATNPC--GIDNGGCSHLCLMSPV-- 302

Query: 727 DHSPKYTCSCPSGYNVEENGRDCQ 750
              P Y C+CP+G  + ENG+ C+
Sbjct: 303 --KPFYQCACPTGVKLLENGKTCK 324



 Score =  218 bits (554), Expect = 2e-56
 Identities = 132/440 (30%), Positives = 213/440 (48%), Gaps = 79/440 (17%)

Query: 358 NECLVNNGGCSHIC--KDLVIGYECDCAAGFELIDR-KTCGDIDECQNPGICSQICINLK 414
           N C ++NGGCSH+C    +   Y+C C  G +L++  KTC D                  
Sbjct: 284 NPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKD------------------ 325

Query: 415 GGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLV---EQLRNT 471
                                  G    L+   R D+R+I L+  ++  +V   E +R+ 
Sbjct: 326 -----------------------GATELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHA 362

Query: 472 VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
           +A+D D     ++W D   +AI  + ID   G    +   + +P  IAVDWV + +YWTD
Sbjct: 363 IAIDYDPVEGYIYWTDDEVRAIRRSFIDGS-GSQFVVTAQIAHPDGIAVDWVARNLYWTD 421

Query: 532 AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDR 591
             +  I V  L+GT RK L + DL EP +I +DP+ G++YW+DWGE  KIE+A ++G DR
Sbjct: 422 TGTDRIEVTRLNGTMRKILISEDLEEPRAIVLDPMVGYMYWTDWGEIPKIERAALDGSDR 481

Query: 592 RPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALT 651
             LV   + WPNG+ LD  + ++YW D+K   +  ++ +G  RR++++  + + H    T
Sbjct: 482 VVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEVMNTDGTGRRVLVE--DKIPHIFGFT 539

Query: 652 IFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIV--YHELVQPSGKNWCEED 709
           +  D VYW D +  ++   +K   +E   +++ L D   +     H ++   G N C E 
Sbjct: 540 LLGDYVYWTDWQRRSIERVHK-RSAEREVIIDQLPDLMGLKATNVHRVI---GSNPCAE- 594

Query: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC---------------QRINV 754
            ENGGC +LCL  PQ         C+CP G+ +  + + C               +RI++
Sbjct: 595 -ENGGCSHLCLYRPQ------GLRCACPIGFELISDMKTCIVPEAFLLFSRRADIRRISL 647

Query: 755 TTAVSEVSVPPKGTSAAWAI 774
            T  + V++P  G   A A+
Sbjct: 648 ETNNNNVAIPLTGVKEASAL 667



 Score =  217 bits (552), Expect = 4e-56
 Identities = 129/395 (32%), Positives = 190/395 (48%), Gaps = 58/395 (14%)

Query: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINLKGG 416
           N C   NGGCSH+C     G  C C  GFELI D KTC                      
Sbjct: 590 NPCAEENGGCSHLCLYRPQGLRCACPIGFELISDMKTC---------------------- 627

Query: 417 YKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLV--EQLRNTVAL 474
                               +  E  L+F+ R DIR+I LE       +    ++   AL
Sbjct: 628 --------------------IVPEAFLLFSRRADIRRISLETNNNNVAIPLTGVKEASAL 667

Query: 475 DADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAAS 534
           D D+   +++W D+S K I  A ++     HV      Y P  +AVDW+ K +YW D  +
Sbjct: 668 DFDVTDNRIYWTDISLKTISRAFMNGSALEHVVEFGLDY-PEGMAVDWLGKNLYWADTGT 726

Query: 535 KTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPL 594
             I V+ LDG  R+ L   DL  P ++A+DP  GF+YW++WG   KI++A M+G +R  L
Sbjct: 727 NRIEVSKLDGQHRQVLVWKDLDSPRALALDPAEGFMYWTEWGGKPKIDRAAMDGSERTTL 786

Query: 595 VTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFE 654
           V  ++   NG+T+D  K RLYW D   +++ S ++ G +R ++    + L HP  LT ++
Sbjct: 787 V-PNVGRANGLTIDYAKRRLYWTDLDTNLIESSNMLGLNREVI---ADDLPHPFGLTQYQ 842

Query: 655 DRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGG 714
           D +YW D    ++  ANK +G     +  +L+   DI+V+H   Q SG N C     NG 
Sbjct: 843 DYIYWTDWSRRSIERANKTSGQNRTIIQGHLDYVMDILVFHSSRQ-SGWNECAS--SNGH 899

Query: 715 CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
           C +LCL  P        + C CP+ Y++  + R C
Sbjct: 900 CSHLCLAVP-----VGGFVCGCPAHYSLNADNRTC 929



 Score =  143 bits (361), Expect = 6e-34
 Identities = 107/354 (30%), Positives = 179/354 (50%), Gaps = 27/354 (7%)

Query: 398  DECQNP-GICSQICINLK-GGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIG 455
            +EC +  G CS +C+ +  GG+ C C   Y ++     C A      L+F+ +  I ++ 
Sbjct: 891  NECASSNGHCSHLCLAVPVGGFVCGCPAHYSLNADNRTCSA--PTTFLLFSQKSAINRMV 948

Query: 456  LERKE---YIQLVEQLRNTVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNV 512
            ++ ++    I  +  LRN  A+D D   ++L+W D  Q  I  A  D   G  V ++ +V
Sbjct: 949  IDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTV-VVSSV 1007

Query: 513  ------YNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPASIAVDPL 566
                    P  +++D   + IYWT  A+  I+V  LDG     +   +   P ++ V+P 
Sbjct: 1008 PSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGRSVGVVLKGEQDRPRAVVVNPE 1067

Query: 567  SGFVYWSDWGEPA-KIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLS 625
             G++Y+++  E + KIE+A ++G +R  L  + +  P  + LD    +L+W DS L  + 
Sbjct: 1068 KGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWADSDLRRIE 1127

Query: 626  SVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELATLVN-N 684
            S DL+G + RIVL+    L  P+ LT+FE+ +YWID + + +   +  TG E  T V   
Sbjct: 1128 SSDLSGAN-RIVLEDSNIL-QPVGLTVFENWLYWIDKQQQMIEKID-MTGREGRTKVQAR 1184

Query: 685  LNDAQDIIVYHEL-VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCP 737
            +    DI    EL +Q   ++ C +D  NGGC ++CL      D + +  CSCP
Sbjct: 1185 IAQLSDIHAVKELNLQEYRQHPCAQD--NGGCSHICLVK---GDGTTR--CSCP 1231



 Score =  115 bits (287), Expect = 2e-25
 Identities = 60/132 (45%), Positives = 75/132 (56%), Gaps = 13/132 (9%)

Query: 184  DELDCA-PPTCGAHEFQCSTSS--CIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP 240
            DEL C  PPTC   +F C T    CIP++W CD   +C D SDE    C   PV    C 
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDEL--NC---PV----CS 1289

Query: 241  ASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGI 300
             S+ QC SG+CI    RC+GD +C+D SDE NC    C  DQF C +G CI   ++C+  
Sbjct: 1290 ESQFQCASGQCIDGALRCNGDANCQDKSDEKNC-EVLCLIDQFRCANGQCIGKHKKCDHN 1348

Query: 301  RDCVDGSDEVNC 312
             DC D SDE++C
Sbjct: 1349 VDCSDKSDELDC 1360



 Score =  108 bits (270), Expect = 2e-23
 Identities = 55/124 (44%), Positives = 71/124 (57%), Gaps = 11/124 (8%)

Query: 229  CGRQPVIHTKCPASEIQCGSGE--CIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECE 286
            CG  P     C   +  C +GE  CI   WRCDG  +C+D SDE+NCP   C   QF+C 
Sbjct: 1243 CGEPPT----CSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCP--VCSESQFQCA 1296

Query: 287  DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRD 346
             G CI G+ +CNG  +C D SDE NC+ +  CL   +F+C +G+CI   K C+   DC D
Sbjct: 1297 SGQCIDGALRCNGDANCQDKSDEKNCEVL--CL-IDQFRCANGQCIGKHKKCDHNVDCSD 1353

Query: 347  WSDE 350
             SDE
Sbjct: 1354 KSDE 1357



 Score =  107 bits (268), Expect = 4e-23
 Identities = 62/159 (38%), Positives = 85/159 (53%), Gaps = 17/159 (10%)

Query: 42   NGRCITL-LWKCDGDEDC------VDGSDEKNCVKK-TCAESDFVCNNGQ--CVPSRWKC 91
            NG C  + L K DG   C      V   DE +C +  TC+   F C  G+  C+P  W+C
Sbjct: 1211 NGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSPQQFTCFTGEIDCIPVAWRC 1270

Query: 92   DGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGN 151
            DG  +CED SDE     +   C   +  C   S QCI  + RC+G+ +C    DE+NC  
Sbjct: 1271 DGFTECEDHSDE----LNCPVCSESQFQCA--SGQCIDGALRCNGDANCQDKSDEKNC-E 1323

Query: 152  ITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAP 190
            + C  D+F C++G+CI ++  C+   DCSD SDELDC P
Sbjct: 1324 VLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSDELDCYP 1362



 Score = 99.4 bits (246), Expect = 1e-20
 Identities = 50/124 (40%), Positives = 66/124 (53%), Gaps = 9/124 (7%)

Query: 28   GRKAKCEPSQFQCTNGR--CITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCV 85
            G    C P QF C  G   CI + W+CDG  +C D SDE NC    C+ES F C +GQC+
Sbjct: 1244 GEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNC--PVCSESQFQCASGQCI 1301

Query: 86   PSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGED 145
                +C+GD +C+D SDE  + C +  C I +  C   + QCI    +CD   DC    D
Sbjct: 1302 DGALRCNGDANCQDKSDE--KNCEV-LCLIDQFRCA--NGQCIGKHKKCDHNVDCSDKSD 1356

Query: 146  EENC 149
            E +C
Sbjct: 1357 ELDC 1360



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 21/53 (39%), Positives = 27/53 (50%), Gaps = 6/53 (11%)

Query: 352  LKECHINECLVNNGGCSHICKDLVIG---YECDCAAGFELI-DRKTCGDIDEC 400
            L+E   + C  +NGGCSHIC  LV G     C C     L+ D  +CG+   C
Sbjct: 1199 LQEYRQHPCAQDNGGCSHIC--LVKGDGTTRCSCPMHLVLLQDELSCGEPPTC 1249


>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
           sapiens]
          Length = 1207

 Score =  217 bits (552), Expect = 4e-56
 Identities = 146/489 (29%), Positives = 231/489 (47%), Gaps = 43/489 (8%)

Query: 272 NCPSRTCRPDQFE----CEDGSCIHGSRQ-CNGIRDCV--DGSDEVNCKNVNQCLGPGKF 324
           NC S  C  D       C +G  +   R+ C  + +C   +    + CKN      PG +
Sbjct: 324 NCSSTVCGQDLQSHLCMCAEGYALSRDRKYCEDVNECAFWNHGCTLGCKNT-----PGSY 378

Query: 325 KCRSGECIDISKVCNQEQDCRDWSDEPLKECH-INECLVNNGGCSHICKDLVIGYECDCA 383
            C       +  V   +           K CH +  C  N   CSH C     G  C C 
Sbjct: 379 YCTC----PVGFVLLPDG----------KRCHQLVSCPRNVSECSHDCVLTSEGPLCFCP 424

Query: 384 AGFELI-DRKTCGDIDECQNPGICSQICINLKG-GYKCECSRGYQMDLATGVCKAVGKEP 441
            G  L  D KTC       N G CSQ+C+ L    ++C+C  GY + L    C A G +P
Sbjct: 425 EGSVLERDGKTCSGCSSPDNGG-CSQLCVPLSPVSWECDCFPGYDLQLDEKSCAASGPQP 483

Query: 442 SLIFTNRRDIRKIGLERKEYIQLVEQLRNTV-ALDADIAAQKLFWADLSQKAIFSASIDD 500
            L+F N +DIR +  +  +Y  L+ Q    V ALD D    K+++A  + K I  A++D 
Sbjct: 484 FLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKWIERANMDG 543

Query: 501 KVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFNSDLREPAS 560
              R   + + V  P  +AVDW+ +  YWTD     I  + L+G + K +   ++ +P  
Sbjct: 544 SQ-RERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGKRSKIITKENISQPRG 602

Query: 561 IAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWPNGITLDLIKSRLYWLDSK 620
           IAV P++  ++W+D G   +IE + + G  R  + ++D+ WP+GIT+D +  +LYW D+K
Sbjct: 603 IAVHPMAKRLFWTDTGINPRIESSSLQGLGRLVIASSDLIWPSGITIDFLTDKLYWCDAK 662

Query: 621 LHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGANKFTGSELAT 680
             ++   +L+G  RR + ++   + HP A+ +FED V++ D    +V   NK TG +   
Sbjct: 663 QSVIEMANLDGSKRRRLTQN--DVGHPFAVAVFEDYVWFSDWAMPSVMRVNKRTGKDRVR 720

Query: 681 LVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGY 740
           L  ++     ++V H L +P G + C    +NGGCE++C              CSC  G+
Sbjct: 721 LQGSMLKPSSLVVVHPLAKP-GADPCL--YQNGGCEHIC------KKRLGTAWCSCREGF 771

Query: 741 NVEENGRDC 749
               +G+ C
Sbjct: 772 MKASDGKTC 780



 Score =  108 bits (270), Expect = 2e-23
 Identities = 82/360 (22%), Positives = 160/360 (44%), Gaps = 36/360 (10%)

Query: 411 INLKGGYKCECSRGYQMDLATGVCKAVGKEPSLIFTNRRDIRKIGLERKEYIQLVEQLRN 470
           ++L       C  G         C  VG  P LIF++   I +I  E   Y QLV     
Sbjct: 18  VSLSAPQHWSCPEGTLAGNGNSTC--VGPAPFLIFSHGNSIFRIDTEGTNYEQLVVDAGV 75

Query: 471 TVALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWT 530
           +V +D     ++++W DL ++ +    ++      V  I+   N + +A++W+ + + W+
Sbjct: 76  SVIMDFHYNEKRIYWVDLERQLLQRVFLNGSRQERVCNIEK--NVSGMAINWINEEVIWS 133

Query: 531 DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFD 590
           +     I+V  + G     L  S L+ PA++AVDP+  F++WS       + +A ++G  
Sbjct: 134 NQQEGIITVTDMKGNNSHILL-SALKYPANVAVDPVERFIFWSS-EVAGSLYRADLDGVG 191

Query: 591 RRPLVTADIQWPNGITLDLIKSRLYWL----DSKLHMLSSVDLNGQDRRIVLKSLEFLAH 646
            + L+    +    ++LD++  RL+W+    +    ++ S D +G        S+    H
Sbjct: 192 VKALLETS-EKITAVSLDVLDKRLFWIQYNREGSNSLICSCDYDG-------GSVHISKH 243

Query: 647 P-----LALTIFEDRVYWIDGENEAVYGANKFTGSELA--TLVNNLNDAQDIIVYHELVQ 699
           P      A+++F DR+++   + + ++ ANK TG ++    L ++     ++ V H L Q
Sbjct: 244 PTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGKDMVRINLHSSFVPLGELKVVHPLAQ 303

Query: 700 PSGKN--WCEED----MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
           P  ++  W  E     +  G C      +         + C C  GY +  + + C+ +N
Sbjct: 304 PKAEDDTWEPEQKLCKLRKGNCS-----STVCGQDLQSHLCMCAEGYALSRDRKYCEDVN 358



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 31/69 (44%), Positives = 37/69 (53%), Gaps = 7/69 (10%)

Query: 366 GCSHICKDLVIGYE--CDCAAGFELIDRKTCGDIDECQ-NPGIC---SQICINLKGGYKC 419
           GCS   + +  G +  C C  GF   D K C DIDEC+    +C   S  CIN +GGY C
Sbjct: 839 GCSMYARCISEGEDATCQCLKGFAG-DGKLCSDIDECEMGVPVCPPASSKCINTEGGYVC 897

Query: 420 ECSRGYQMD 428
            CS GYQ D
Sbjct: 898 RCSEGYQGD 906



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 35/124 (28%), Positives = 52/124 (41%), Gaps = 21/124 (16%)

Query: 305 DGSDEVNCKNVNQCLGPGK---FKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECL 361
           D    V C    +C+  G+    +C  G   D  K+C+   +C      P+     ++C+
Sbjct: 833 DDCAPVGCSMYARCISEGEDATCQCLKGFAGD-GKLCSDIDECE--MGVPVCPPASSKCI 889

Query: 362 VNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQ-NPGICSQ--ICINLKGGYK 418
              GG           Y C C+ G++  D   C DIDECQ     C +   C N +GGY 
Sbjct: 890 NTEGG-----------YVCRCSEGYQG-DGIHCLDIDECQLGEHSCGENASCTNTEGGYT 937

Query: 419 CECS 422
           C C+
Sbjct: 938 CMCA 941



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 21/49 (42%), Positives = 26/49 (53%), Gaps = 1/49 (2%)

Query: 351 PLKECHINECLVNNGGCSHICKDLVIGYECDCAAGF-ELIDRKTCGDID 398
           PL +   + CL  NGGC HICK  +    C C  GF +  D KTC  +D
Sbjct: 736 PLAKPGADPCLYQNGGCEHICKKRLGTAWCSCREGFMKASDGKTCLALD 784


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score =  181 bits (458), Expect = 3e-45
 Identities = 106/319 (33%), Positives = 139/319 (43%), Gaps = 63/319 (19%)

Query: 33   CEPSQFQCT-NGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKC 91
            C   +  C  NG C+   W CD  +DC DGSDE+ C    C E    C++G C+P    C
Sbjct: 1376 CAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLC 1435

Query: 92   DGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC-G 150
            D   DC DG+DE    C         ++C     +C+P +  CDG  DC    DEE+C G
Sbjct: 1436 DRQDDCGDGTDEPSYPCPQGL-----LACA--DGRCLPPALLCDGHPDCLDAADEESCLG 1488

Query: 151  NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE------------------------- 185
             +TC P E +C  G C+    +C+G  DC DG+DE                         
Sbjct: 1489 QVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGS 1548

Query: 186  LDCA---------PPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIH 236
            LD A          P CG  EF+C +  C P  W CD + DC+D SDE    CG      
Sbjct: 1549 LDTASSPLASASPAPPCGPFEFRCGSGECTPRGWRCDQEEDCADGSDE--RGCG------ 1600

Query: 237  TKCPASEIQCGSG-ECIHKKWRCDGDPDCKDGSDE----------VNCPSRTCRP-DQFE 284
              C      C  G  C+  +  CDG   C DGSDE          +  P+RT  P  ++ 
Sbjct: 1601 GPCAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYT 1660

Query: 285  CEDGSCIHGSRQCNGIRDC 303
            C +G+CI     C+G  DC
Sbjct: 1661 CPNGTCIGFQLVCDGQPDC 1679



 Score =  161 bits (408), Expect = 2e-39
 Identities = 96/319 (30%), Positives = 135/319 (42%), Gaps = 75/319 (23%)

Query: 95   PDCEDGSDESPEQCHMRTCRIHEISCGA----HSTQCI-PVSWRCD-GENDCDSGED-EE 147
            P C +   E    C +  C +    C      H   C+ P S  C+ G N    G   ++
Sbjct: 1290 PTCHEQHPEPGWHCQVVAC-VEGCFCPEGTLLHGGACLEPASCPCEWGRNSFPPGSVLQK 1348

Query: 148  NCGNITCSPDEFTCS----------------------SGRCISRNFVCNGQDDCSDGSDE 185
            +CGN TC   ++ C                       +G C+   ++C+ QDDC DGSDE
Sbjct: 1349 DCGNCTCQEGQWHCGGDGGHCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDE 1408

Query: 186  LDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQ 245
              CA P CG  +  CS+  C+P++ +CD   DC D +DE              CP   + 
Sbjct: 1409 EGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEP----------SYPCPQGLLA 1458

Query: 246  CGSGECIHKKWRCDGDPDCKDGSDEVNCPSR-TCRPDQFECEDGSCIHGSRQCNGIRDCV 304
            C  G C+     CDG PDC D +DE +C  + TC P +  C DG+C+   + C+G+ DC 
Sbjct: 1459 CADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCP 1518

Query: 305  DGSDE---------------------------------VNCKNVNQCLGPGKFKCRSGEC 331
            DG+DE                                  +      C GP +F+C SGEC
Sbjct: 1519 DGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPC-GPFEFRCGSGEC 1577

Query: 332  IDISKVCNQEQDCRDWSDE 350
                  C+QE+DC D SDE
Sbjct: 1578 TPRGWRCDQEEDCADGSDE 1596



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 83/351 (23%), Positives = 118/351 (33%), Gaps = 59/351 (16%)

Query: 21   ESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCN 80
            +S A G     +C P Q  C    C+     CDG EDC+DGSDE++C +           
Sbjct: 2379 QSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLP---- 2434

Query: 81   NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDC 140
                +P+ W     P                 C   ++SCG  S +C+    RCD   DC
Sbjct: 2435 ---SLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCG--SGECLSAERRCDLRPDC 2489

Query: 141  DSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC 200
              G DE+ C +   +P     S  R          Q+          C  P        C
Sbjct: 2490 QDGSDEDGCVDCVLAPWSVWSSCSRSCGLGLTFQRQELLRPPLPGGSC--PRDRFRSQSC 2547

Query: 201  STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDG 260
               +C P++                    G   +     P S + CG G     + R   
Sbjct: 2548 FVQAC-PVA--------------------GAWAMWEAWGPCS-VSCGGGH--QSRQRSCV 2583

Query: 261  DPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQ--- 317
            DP  K+G     CP  +   ++  C       G + C+G  DC  G   V+     +   
Sbjct: 2584 DPPPKNGG--APCPGAS--QERAPC-------GLQPCSGGTDCELGRVYVSADLCQKGLV 2632

Query: 318  ------CLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLV 362
                  CL P   +  SG C++  + C       D    PL EC    CLV
Sbjct: 2633 PPCPPSCLDPKANRSCSGHCVEGCR-CPPGLLLHDTRCLPLSEC---PCLV 2679



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 72/290 (24%), Positives = 99/290 (34%), Gaps = 89/290 (30%)

Query: 97   CEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSP 156
            CE GS  +P       C    + C   S +C+     CDG  DC+ G DEE C  +    
Sbjct: 2224 CEPGSPPAP------LCPGVGLRCA--SGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGT 2275

Query: 157  DEFTCSSGRCISRNFVCNGQ--DDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDD 214
              F  S+ + ++ +    GQ      +G  E +  PP     E   S +   P+S     
Sbjct: 2276 GRFH-STAKTLALSSAQPGQLLHWPREGLAETEHWPP---GQESPTSPTETRPVS---PG 2328

Query: 215  DADCSDQSDESLEQCGRQPV-------------------IHTKCPAS------------E 243
             A       ES++     P+                    H   PA+             
Sbjct: 2329 PASGVPHHGESVQMVTTTPIPQMEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPP 2388

Query: 244  IQCGSGE-------CIHKKWRCDGDPDCKDGSDEVNC--------PS------------- 275
            +QCG G+       C+ +   CDG  DC DGSDE +C        PS             
Sbjct: 2389 VQCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFM 2448

Query: 276  -------------RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNC 312
                           C P Q  C  G C+   R+C+   DC DGSDE  C
Sbjct: 2449 MPTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGC 2498



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 21/61 (34%), Positives = 29/61 (47%), Gaps = 6/61 (9%)

Query: 264  CKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGK 323
            C+ GS     P+  C      C  G C+     C+G+ DC DGSDE  C  + +  G G+
Sbjct: 2224 CEPGSP----PAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPE--GTGR 2277

Query: 324  F 324
            F
Sbjct: 2278 F 2278



 Score = 39.3 bits (90), Expect = 0.015
 Identities = 16/36 (44%), Positives = 20/36 (55%)

Query: 33   CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCV 68
            C     +C +G C+     CDG  DC DGSDE+ CV
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCV 2269



 Score = 37.4 bits (85), Expect = 0.059
 Identities = 66/316 (20%), Positives = 97/316 (30%), Gaps = 77/316 (24%)

Query: 66   NCVKKTCAESDFVCNNGQC-VPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHS 124
            NC +  C + + +C  G C +P  W         D S  S  +   R            S
Sbjct: 2694 NCSQCVCEKGELLCQPGGCPLPCGWSAWSSWAPCDRSCGSGVRARFR------------S 2741

Query: 125  TQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEF---------TCSSGRCI-------- 167
                P +W   G   C+    E    +  C  + F         +CS   C+        
Sbjct: 2742 PSNPPAAW---GGAPCEGDRQELQGCHTVCGTEVFGWTPWTSWSSCSQS-CLAPGGGPGW 2797

Query: 168  -SRNFVCNGQDDCS---DGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSD 223
             SR+ +C    D S   D + E  C+PP C         +     S  CD       +S 
Sbjct: 2798 RSRSRLCPSPGDSSCPGDATQEEPCSPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSC 2857

Query: 224  ESL--------------EQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSD 269
             SL                C  QP    +CP + +   + +C  +   C     C     
Sbjct: 2858 SSLAPGDTTCPGPHSQTRDCNTQPCT-AQCPENMLFRSAEQCHQEGGPC--PRLCLTQGP 2914

Query: 270  EVNC-----PSRTCRPDQFECEDGSC---------IHGSRQCNGIRDCVDGSDEVNCKNV 315
             + C     P  TC P  F   + SC         +HG    +G    +D  +   C + 
Sbjct: 2915 GIECTGFCAPGCTCPPGLF-LHNASCLPRSQCPCQLHGQLYASGAMARLDSCNNCTCVS- 2972

Query: 316  NQCLGPGKFKCRSGEC 331
                  GK  C S  C
Sbjct: 2973 ------GKMACTSERC 2982



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 15/25 (60%), Positives = 17/25 (68%)

Query: 79   CNNGQCVPSRWKCDGDPDCEDGSDE 103
            C +G+CV     CDG  DCEDGSDE
Sbjct: 2241 CASGECVLRGGPCDGVLDCEDGSDE 2265



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 49/206 (23%), Positives = 71/206 (34%), Gaps = 46/206 (22%)

Query: 186  LDCAP-----PTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPV----IH 236
            L C P     P C     +C++  C+     CD   DC D SDE  E C   P      H
Sbjct: 2222 LGCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDE--EGCVLLPEGTGRFH 2279

Query: 237  TKCPASEIQCGS-GECIHKKWRCDGDPDCK---DGSDEVNCPSRTCRPDQFECEDGSCIH 292
            +      +     G+ +H  W  +G  + +    G +    P+ T RP       G   H
Sbjct: 2280 STAKTLALSSAQPGQLLH--WPREGLAETEHWPPGQESPTSPTET-RPVSPGPASGVPHH 2336

Query: 293  GSR---------QCNGIRDCVDGSDEVN---------CKNVNQCLGPGKF---KCRSGE- 330
            G                R    G   V               Q + PG F   +C  G+ 
Sbjct: 2337 GESVQMVTTTPIPQMEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQT 2396

Query: 331  ------CIDISKVCNQEQDCRDWSDE 350
                  C++ ++VC+  +DC D SDE
Sbjct: 2397 PCEVLGCVEQAQVCDGREDCLDGSDE 2422



 Score = 33.9 bits (76), Expect = 0.65
 Identities = 40/200 (20%), Positives = 67/200 (33%), Gaps = 35/200 (17%)

Query: 96   DCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCD-----GENDCDSGEDEENCG 150
            D ++G     +Q   + CR  + S       C+P+   CD     G +     + ++ C 
Sbjct: 4081 DLQEGIVCQDDQVCQKGCRCPKGSL-EQDGGCVPIG-HCDCTDAQGHSWAPGSQHQDACN 4138

Query: 151  NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISW 210
            N +C   + +C++  C             S  S    C+  +CG    Q    S    SW
Sbjct: 4139 NCSCQAGQLSCTAQPCPPPTHCA-----WSHWSAWSPCS-HSCGPRGQQSRFRSSTSGSW 4192

Query: 211  VCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDE 270
                  +C ++  +S      QP     CP   +Q      +   W             +
Sbjct: 4193 A----PECREEQSQS------QPCPQPSCPPLCLQGTRSRTLGDSWL------------Q 4230

Query: 271  VNCPSRTCRPDQFECEDGSC 290
              C   +C P+   CED  C
Sbjct: 4231 GECQRCSCTPEGVICEDTEC 4250



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 68/296 (22%), Positives = 93/296 (31%), Gaps = 51/296 (17%)

Query: 133  RCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQD-----DCSDGSDELD 187
            R DG N C   E   NC ++ C      C        +  C GQ       C+  + +  
Sbjct: 3384 RPDGCNHCTCLEGRLNCTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHG 3443

Query: 188  CAPPTCGAHEF-------QCSTSSCIPIS-----WVCDDDAD-CSDQSDESLEQCGRQPV 234
             AP T  A E         C + +  P+      W      D C  QS  S   C R P 
Sbjct: 3444 GAPCTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDMCLGQSHRS-RACSRPPT 3502

Query: 235  IH--TKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIH 292
                  CP +  Q  S  C     +C    DC  G     C     R  Q       C  
Sbjct: 3503 PEGGRPCPGNHTQ--SRPCQENSTQC---TDCGGGQSLHPCGQPCPRSCQDLSPGSVCQP 3557

Query: 293  GSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDEP 351
            GS  C     C  G           C+ P   +C+     + I +  ++    R  S E 
Sbjct: 3558 GSVGCQPTCGCPLG----QLSQDGLCVPPAHCRCQYQPGAMGIPENQSRSAGSRFSSWES 3613

Query: 352  LKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICS 407
            L+        V  G C +          C C AG        C ++ +C +PG+ S
Sbjct: 3614 LEPGE-----VVTGPCDN----------CTCVAGI-----LQCQEVPDCPDPGVWS 3649



 Score = 30.4 bits (67), Expect = 7.2
 Identities = 23/81 (28%), Positives = 30/81 (37%), Gaps = 3/81 (3%)

Query: 264  CKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGK 323
            C D  D V C    CRP    C  G  +   R C  I  C  G    N           +
Sbjct: 4686 CADLWDRVQCLQGPCRPG-CRCPPGQLVQDGR-CVPISSCRCGLPSANASWELAPAQAVQ 4743

Query: 324  FKCRSGECIDISKVCNQEQDC 344
              C++  C++ S VC   Q+C
Sbjct: 4744 LDCQNCTCVNESLVC-PHQEC 4763



 Score = 30.0 bits (66), Expect = 9.4
 Identities = 59/270 (21%), Positives = 86/270 (31%), Gaps = 45/270 (16%)

Query: 79   CNNGQCVPSRWKCDGDPDCEDGSDESP----EQC--------HMRTCRIHEISCGAHSTQ 126
            C+N  CV    +C   PDC D    S     E C         +R+ R     C   + Q
Sbjct: 3624 CDNCTCVAGILQCQEVPDCPDPGVWSSWGPWEDCSVSCGGGEQLRSRRCARPPCPGPARQ 3683

Query: 127  CIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDEL 186
                S +   E  C +G          C P E    S   +++   C      S+G +E 
Sbjct: 3684 SRTCSTQVCREAGCPAGRLYRE-----CQPGEGCPFSCAHVTQQVGC-----FSEGCEEG 3733

Query: 187  DCAPPTCGAHEFQC-STSSCIPISWVCDDDADCSDQSDESL---EQCGRQPVIHTKCPAS 242
               P     H   C     C+  +W+  +         + L   ++      + T     
Sbjct: 3734 CHCPEGTFQHRLACVQECPCVLTAWLLQELGATIGDPGQPLGPGDELDSGQTLRT----- 3788

Query: 243  EIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRD 302
               CG+  C H K  C  D DC + +D    P     P    C        SRQC     
Sbjct: 3789 --SCGNCSCAHGKLSCSLD-DCFE-ADGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMP 3844

Query: 303  CVDGSDEVNCKNVNQCLGPGK-FKCRSGEC 331
             + G           C GP +  +C S +C
Sbjct: 3845 TLSGQG---------CRGPRQDLECPSPDC 3865


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  177 bits (450), Expect = 3e-44
 Identities = 145/510 (28%), Positives = 215/510 (42%), Gaps = 108/510 (21%)

Query: 15  LCWAPRESGATGTGRKAKCEPSQ-FQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCA 73
           +C++P++      G++  C   + F C +G CI    +C+G  DC D SDE +C    C+
Sbjct: 255 ICFSPQQEN----GKQLLCGRGENFLCASGICIPGKLQCNGYNDCDDWSDEAHC---NCS 307

Query: 74  ESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWR 133
           E+ F C+ G+C+     CDG  DC D SDE    C+  T    E  CG    +CI + W 
Sbjct: 308 ENLFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCDCNPTT----EHRCG--DGRCIAMEWV 361

Query: 134 CDGENDCDSGEDEENCGNITC-SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCA--P 190
           CDG++DC    DE NC   +C S     C +G+CI   F C+G +DC DGSDE +C+   
Sbjct: 362 CDGDHDCVDKSDEVNC---SCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQ 418

Query: 191 PTCGAHEFQCSTSSCIPI---SWVCDDD---ADCSDQSDESLEQCGRQP----------- 233
            +C   + +C  + C+     S +CD +    +CS     +LE C   P           
Sbjct: 419 TSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFG 478

Query: 234 ------------------VIHTKC-------------PASEIQCGS------GECIHKKW 256
                             ++ T C             P  ++  G         C H K 
Sbjct: 479 HRTQKEASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKE 538

Query: 257 RCDG-----------DPDC----KDGSDEVNCPS-----RTCRPDQFECEDGSCIHGSRQ 296
           RC+            D DC    ++ SD   C         C P  F+C  G C+  SR+
Sbjct: 539 RCESVLGIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRR 598

Query: 297 CNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG-ECIDISKVCNQEQDCRDWSDEP-LKE 354
           C+G  DC D SDE NC     C     ++C S  +C+  + +C+   DC D+ DE     
Sbjct: 599 CDGQADCDDDSDEENC----GCKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNCSF 654

Query: 355 CHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQICINLK 414
           C  +E    N  C  + +DL    E DC+   +  D  T        N    S + ++  
Sbjct: 655 CQDDELECANHAC--VSRDLWCDGEADCSDSSDEWDCVTLS-----INVNSSSFLMVHRA 707

Query: 415 GGYKCECSRGYQMDLATGVCKAVG-KEPSL 443
                 C+ G+Q  L+   CK +G  EPS+
Sbjct: 708 ATEHHVCADGWQEILSQLACKQMGLGEPSV 737



 Score =  108 bits (269), Expect = 3e-23
 Identities = 105/434 (24%), Positives = 159/434 (36%), Gaps = 119/434 (27%)

Query: 39  QCTNGRCITLLWKCDGDEDCVDGSD--------------EKNCVKKTCAESDFVCNNGQC 84
           +C NG+CI   ++CDGDEDC DGSD              ++ C+   C +S   C     
Sbjct: 386 ECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQEGDQRCLYNPCLDS---CGGSSL 442

Query: 85  VPSRWKCDGDPDCED-----------GSDESPEQCHMRT--------------------- 112
                  +    CE             S   P     RT                     
Sbjct: 443 CDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTNC 502

Query: 113 --------CRIHEISCGAHSTQCIPV--------SWRCDG-----------ENDCDSGED 145
                   C I    C  ++ + IP           RC+            + DC S   
Sbjct: 503 YKYLMFFSCTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPEDTDC-SQFP 561

Query: 146 EENCGNITC----------SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGA 195
           EEN  N TC          SP  F C SG+C+  +  C+GQ DC D SDE +C    C  
Sbjct: 562 EENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCG---CKE 618

Query: 196 HE-FQC-STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIH 253
            + ++C S   C+  + +CD   DC D  DE  + C       + C   E++C +  C+ 
Sbjct: 619 RDLWECPSNKQCLKHTVICDGFPDCPDYMDE--KNC-------SFCQDDELECANHACVS 669

Query: 254 KKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCK 313
           +   CDG+ DC D SDE +C + +           S +   R       C DG  E+  +
Sbjct: 670 RDLWCDGEADCSDSSDEWDCVTLS-----INVNSSSFLMVHRAATEHHVCADGWQEILSQ 724

Query: 314 NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDW-----SDEPLKECHINECLVNNGGCS 368
              + +G G+          ++K+  +++    W     + E L    ++E LVN   C 
Sbjct: 725 LACKQMGLGE--------PSVTKLIQEQEKEPRWLTLHSNWESLNGTTLHELLVNGQSCE 776

Query: 369 HICKDLVIGYECDC 382
              K  ++  + DC
Sbjct: 777 SRSKISLLCTKQDC 790


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  145 bits (366), Expect = 2e-34
 Identities = 70/162 (43%), Positives = 94/162 (58%), Gaps = 18/162 (11%)

Query: 156 PDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGA-HEFQCSTSSCIPISWVCDD 214
           P +FTC +GRCI +   C+G  DC+D SDEL+C+   C A H+F C    C P+ WVCD 
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS---CDAGHQFTCKNKFCKPLFWVCDS 510

Query: 215 DADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP 274
             DC D SDE  + C         CPA   +C +G+C+ K  +C+G  DC DGSDE +CP
Sbjct: 511 VNDCGDNSDE--QGCS--------CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCP 560

Query: 275 S---RTCRPDQFECEDGSCI-HGSRQCNGIRDCVDGSDEVNC 312
                TC    + C +G C+  G+ +C+G  DC DGSDE +C
Sbjct: 561 KVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602



 Score =  131 bits (329), Expect = 3e-30
 Identities = 70/169 (41%), Positives = 90/169 (53%), Gaps = 18/169 (10%)

Query: 35  PSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTC-AESDFVCNNGQCVPSRWKCDG 93
           P QF C  GRCI    +CDG  DC D SDE NC   +C A   F C N  C P  W CD 
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNC---SCDAGHQFTCKNKFCKPLFWVCDS 510

Query: 94  DPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGN-- 151
             DC D SDE    C  +T R         + +C+  S +C+G++DC  G DE +C    
Sbjct: 511 VNDCGDNSDEQGCSCPAQTFR-------CSNGKCLSKSQQCNGKDDCGDGSDEASCPKVN 563

Query: 152 -ITCSPDEFTCSSGRCISR-NFVCNGQDDCSDGSDELDCAPPTCGAHEF 198
            +TC+   + C +G C+S+ N  C+G++DCSDGSDE DC    CG   F
Sbjct: 564 VVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC---DCGLRSF 609



 Score =  123 bits (308), Expect = 8e-28
 Identities = 62/158 (39%), Positives = 81/158 (51%), Gaps = 13/158 (8%)

Query: 77  FVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDG 136
           F C  G+C+    +CDG  DC D SDE    C       H+ +C   +  C P+ W CD 
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAG----HQFTC--KNKFCKPLFWVCDS 510

Query: 137 ENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAP---PTC 193
            NDC    DE+ C   +C    F CS+G+C+S++  CNG+DDC DGSDE  C      TC
Sbjct: 511 VNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC 567

Query: 194 GAHEFQCSTSSCIPI-SWVCDDDADCSDQSDESLEQCG 230
             H ++C    C+   +  CD   DCSD SDE    CG
Sbjct: 568 TKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCG 605



 Score =  103 bits (258), Expect = 5e-22
 Identities = 63/172 (36%), Positives = 83/172 (48%), Gaps = 20/172 (11%)

Query: 187 DCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPAS-EIQ 245
           D + P  G  +F C T  CI     CD  ADC+D SDE          ++  C A  +  
Sbjct: 448 DSSDPCPG--QFTCRTGRCIRKELRCDGWADCTDHSDE----------LNCSCDAGHQFT 495

Query: 246 CGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSRQCNGIRDCVD 305
           C +  C    W CD   DC D SDE  C   +C    F C +G C+  S+QCNG  DC D
Sbjct: 496 CKNKFCKPLFWVCDSVNDCGDNSDEQGC---SCPAQTFRCSNGKCLSKSQQCNGKDDCGD 552

Query: 306 GSDEVNCKNVNQCL-GPGKFKCRSGECIDISKV-CNQEQDCRDWSDEPLKEC 355
           GSDE +C  VN        ++C +G C+      C+ ++DC D SDE  K+C
Sbjct: 553 GSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDE--KDC 602



 Score = 80.5 bits (197), Expect = 6e-15
 Identities = 38/105 (36%), Positives = 57/105 (54%), Gaps = 4/105 (3%)

Query: 12  LLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVK-- 69
           L  +C +  + G     +   C    F+C+NG+C++   +C+G +DC DGSDE +C K  
Sbjct: 504 LFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVN 563

Query: 70  -KTCAESDFVCNNGQCV-PSRWKCDGDPDCEDGSDESPEQCHMRT 112
             TC +  + C NG C+     +CDG  DC DGSDE    C +R+
Sbjct: 564 VVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDCGLRS 608



 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 49/158 (31%), Positives = 66/158 (41%), Gaps = 28/158 (17%)

Query: 280 PDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCN 339
           P QF C  G CI    +C+G  DC D SDE+NC     C    +F C++  C  +  VC+
Sbjct: 454 PGQFTCRTGRCIRKELRCDGWADCTDHSDELNCS----CDAGHQFTCKNKFCKPLFWVCD 509

Query: 340 QEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDID- 398
              DC D SDE    C       +NG C  + K      + DC  G    D  +C  ++ 
Sbjct: 510 SVNDCGDNSDEQGCSCPAQTFRCSNGKC--LSKSQQCNGKDDCGDG---SDEASCPKVNV 564

Query: 399 --------ECQNPGICSQICINLKGGYKC----ECSRG 424
                    C N G+C       KG  +C    +CS G
Sbjct: 565 VTCTKHTYRCLN-GLCLS-----KGNPECDGKEDCSDG 596


>gi|115298674 nidogen 1 precursor [Homo sapiens]
          Length = 1247

 Score =  137 bits (345), Expect = 4e-32
 Identities = 87/268 (32%), Positives = 136/268 (50%), Gaps = 15/268 (5%)

Query: 472  VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMI-DNVYNPAAIAVDWVYKTIYWT 530
            + L  D   + ++W D+++ +I  AS+    G    +I  ++ +P  IAVD + + I+WT
Sbjct: 981  IGLAFDCVDKMVYWTDITEPSIGRASLHG--GEPTTIIRQDLGSPEGIAVDHLGRNIFWT 1038

Query: 531  DAASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG-EPAKIEKAGMNGF 589
            D+    I VA LDGT+R+ LF +DL  P  I  D + G +YW+DW  +  KIE + M+G 
Sbjct: 1039 DSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWTDWNRDNPKIETSYMDGT 1098

Query: 590  DRRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLA 649
            +RR LV  D+  PNG+T D   S+L W+D+  +    ++ +   RR   K+LE L +P A
Sbjct: 1099 NRRILVQDDLGLPNGLTFDAFSSQLCWVDAGTNRAECLNPSQPSRR---KALEGLQYPFA 1155

Query: 650  LTIFEDRVYWIDGENEAVYGANKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEED 709
            +T +   +Y+ D +  +V   +     E      +       I       P G N+C   
Sbjct: 1156 VTSYGKNLYFTDWKMNSVVALDLAISKETDAFQPHKQTRLYGITTALSQCPQGHNYC--S 1213

Query: 710  MENGGCEYLCLPAPQINDHSPKYTCSCP 737
            + NGGC +LCL  P         TC CP
Sbjct: 1214 VNNGGCTHLCLATP------GSRTCRCP 1235



 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 53/169 (31%), Positives = 66/169 (39%), Gaps = 36/169 (21%)

Query: 278 CRPD---QFECEDGSCIHGS-RQCNGIRDC-----VDGSDEVNCKNVNQCLGPGKFKCRS 328
           CRP    QF CE      G  R C  I +C     V GS  + C N      PG F+C  
Sbjct: 685 CRPGPRTQFTCECSIGFRGDGRTCYDIDECSEQPSVCGSHTI-CNN-----HPGTFRCEC 738

Query: 329 GECIDISK----VCNQEQDCRDWSDEPLKECHINE---CLVNNGGCSHICKDLVIGYECD 381
            E    S     V   +Q   ++ +  L  C I +   C+   G            Y C 
Sbjct: 739 VEGYQFSDEGTCVAVVDQRPINYCETGLHNCDIPQRAQCIYTGGS----------SYTCS 788

Query: 382 CAAGFELIDRKTCGDIDECQNPGIC--SQICINLKGGYKCECSRGYQMD 428
           C  GF   D + C D+DECQ P  C     C N  G + C+C  GYQ D
Sbjct: 789 CLPGFSG-DGQACQDVDECQ-PSRCHPDAFCYNTPGSFTCQCKPGYQGD 835



 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 33/121 (27%), Positives = 57/121 (47%), Gaps = 5/121 (4%)

Query: 545  TKRKFLFNSDLREPASI----AVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQ 600
            T RK    + L  PA +    A D +   VYW+D  EP+ I +A ++G +   ++  D+ 
Sbjct: 963  TMRKTEAKAFLHVPAKVIIGLAFDCVDKMVYWTDITEPS-IGRASLHGGEPTTIIRQDLG 1021

Query: 601  WPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWI 660
             P GI +D +   ++W DS L  +    L+G  RR++ ++       +        +YW 
Sbjct: 1022 SPEGIAVDHLGRNIFWTDSNLDRIEVAKLDGTQRRVLFETDLVNPRGIVTDSVRGNLYWT 1081

Query: 661  D 661
            D
Sbjct: 1082 D 1082



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 33/86 (38%), Positives = 44/86 (51%), Gaps = 8/86 (9%)

Query: 358 NECLVNNGGC--SHICKDLV-IGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQ--ICI 411
           N C +   GC  +  C+      + C+C+ GF   D +TC DIDEC + P +C    IC 
Sbjct: 670 NPCYIGTHGCDTNAACRPGPRTQFTCECSIGFRG-DGRTCYDIDECSEQPSVCGSHTICN 728

Query: 412 NLKGGYKCECSRGYQMDLATGVCKAV 437
           N  G ++CEC  GYQ     G C AV
Sbjct: 729 NHPGTFRCECVEGYQFS-DEGTCVAV 753



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 15/38 (39%), Positives = 20/38 (52%), Gaps = 3/38 (7%)

Query: 358  NECLVNNGGCSHICKDLVIGYECDC---AAGFELIDRK 392
            N C VNNGGC+H+C        C C     G + I++K
Sbjct: 1210 NYCSVNNGGCTHLCLATPGSRTCRCPDNTLGVDCIEQK 1247


>gi|144953895 nidogen 2 precursor [Homo sapiens]
          Length = 1375

 Score =  133 bits (334), Expect = 8e-31
 Identities = 68/205 (33%), Positives = 111/205 (54%), Gaps = 4/205 (1%)

Query: 472  VALDADIAAQKLFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTD 531
            V +D D   + ++W D++ + I  A ++        +   + +P  +A+D + +T+YWTD
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204

Query: 532  AASKTISVATLDGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWG-EPAKIEKAGMNGFD 590
            +    I  A LDG++RK LF +DL  P +IAVDP+ G +YW+DW  E  KIE + ++G +
Sbjct: 1205 SVLDKIESALLDGSERKVLFYTDLVNPRAIAVDPIRGNLYWTDWNREAPKIETSSLDGEN 1264

Query: 591  RRPLVTADIQWPNGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLAL 650
            RR L+  DI  PNG+T D     L W D+    L     +G  RR++  +L++   P ++
Sbjct: 1265 RRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKY---PFSI 1321

Query: 651  TIFEDRVYWIDGENEAVYGANKFTG 675
              + D  Y  D   + V   NK +G
Sbjct: 1322 VSYADHFYHTDWRRDGVVSVNKHSG 1346



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 55/192 (28%), Positives = 74/192 (38%), Gaps = 42/192 (21%)

Query: 259 DGDPD----CKDGSDEVNCPSRTCRPD---QFECEDGSCIHGS-RQCNGIRDCVDGSDEV 310
           D DP     C DGS   +  +R C P     + CE  S   G  R C    +C  G    
Sbjct: 754 DSDPTPGNPCYDGSHMCDTTAR-CHPGTGVDYTCECASGYQGDGRNCVDENECATGFHRC 812

Query: 311 NCKNVNQCLG-PGKFKC--RSG--------ECIDISKVCNQEQDCRDWSDE--PLKECHI 357
              +V  C+  PG ++C  RSG         CI I+   N    C D S    P  +   
Sbjct: 813 GPNSV--CINLPGSYRCECRSGYEFADDRHTCILITPPANP---CEDGSHTCAPAGQARC 867

Query: 358 NECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQICINLKGG 416
               V++GG +         + C C  G+   D   C D+DEC +N    +  C N  G 
Sbjct: 868 ----VHHGGST---------FSCACLPGYAG-DGHQCTDVDECSENRCHPAATCYNTPGS 913

Query: 417 YKCECSRGYQMD 428
           + C C  GY  D
Sbjct: 914 FSCRCQPGYYGD 925


>gi|32698824 low density lipoprotein receptor-related protein 5-like
           [Homo sapiens]
          Length = 252

 Score =  126 bits (316), Expect = 1e-28
 Identities = 63/190 (33%), Positives = 106/190 (55%), Gaps = 3/190 (1%)

Query: 483 LFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATL 542
           ++W D    AI  A +D   G    +   + +P  IAV+WV +++YWT   ++ I V  L
Sbjct: 5   VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63

Query: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602
           + T  K L + D+ EP +IA+ P  G  YW DWGE  +I++A ++  + R LV A + WP
Sbjct: 64  NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123

Query: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662
           NG+ LDL + +LYW D+K   + ++ ++   R+ +LK  + L H    T+  D +YW   
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWTAW 181

Query: 663 ENEAVYGANK 672
           ++ ++   +K
Sbjct: 182 QHHSIKRVHK 191


>gi|209447022 low density lipoprotein receptor-related protein
           5-like [Homo sapiens]
          Length = 252

 Score =  126 bits (316), Expect = 1e-28
 Identities = 63/190 (33%), Positives = 106/190 (55%), Gaps = 3/190 (1%)

Query: 483 LFWADLSQKAIFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATL 542
           ++W D    AI  A +D   G    +   + +P  IAV+WV +++YWT   ++ I V  L
Sbjct: 5   VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63

Query: 543 DGTKRKFLFNSDLREPASIAVDPLSGFVYWSDWGEPAKIEKAGMNGFDRRPLVTADIQWP 602
           + T  K L + D+ EP +IA+ P  G  YW DWGE  +I++A ++  + R LV A + WP
Sbjct: 64  NSTSHKILVSEDMDEPRAIALHPEMGLTYWIDWGENPEIKRANLDRQELRVLVNASLGWP 123

Query: 603 NGITLDLIKSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDG 662
           NG+ LDL + +LYW D+K   + ++ ++   R+ +LK  + L H    T+  D +YW   
Sbjct: 124 NGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLK--DKLPHIFRFTLLGDFIYWTAW 181

Query: 663 ENEAVYGANK 672
           ++ ++   +K
Sbjct: 182 QHHSIKRVHK 191


>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
          Length = 4391

 Score =  122 bits (307), Expect = 1e-27
 Identities = 71/211 (33%), Positives = 87/211 (41%), Gaps = 58/211 (27%)

Query: 154 CSPDEFTCSS-GRCISRNFVCNGQDDCSDGSDELDCAPPT-------------------- 192
           C+  EF C S   C++  + C+ + DC D SDEL+C  P                     
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258

Query: 193 --------------------------CGAHEFQCSTSSCIPISWVCDDDADCSDQSDESL 226
                                     CG  E  C    CIP  ++CD   DC D SDE  
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL- 317

Query: 227 EQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSR----TCRPDQ 282
             CG  P     C  +E  CG+G C  K WRCDGD DC+D +DE NCP++     C P Q
Sbjct: 318 -DCGPPP----PCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQ 372

Query: 283 FEC-EDGSCIHGSRQCNGIRDCVDGSDEVNC 312
           F C     CI  S  C+   DC D SDE  C
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403



 Score =  121 bits (303), Expect = 3e-27
 Identities = 73/232 (31%), Positives = 104/232 (44%), Gaps = 53/232 (22%)

Query: 70  KTCAESDFVCNN-GQCVPSRWKCDGDPDCEDGSDE------------------------- 103
           + C E++F C++  +CV   ++CD  PDC D SDE                         
Sbjct: 197 RACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPP 256

Query: 104 SPEQCHMRTC------------RIHEISCGAHST-----QCIPVSWRCDGENDCDSGEDE 146
            PE   MR               +  + CG          CIP  + CDG+ DC+ G DE
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDE 316

Query: 147 ENCG-NITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC----APPTCGAHEFQC- 200
            +CG    C P+EF C +G C  + + C+G  DC D +DE +C        CG  +F+C 
Sbjct: 317 LDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRCV 376

Query: 201 STSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECI 252
           ST+ CIP S+ CD+++DC D+SDE     G  P      P   IQ   G+ +
Sbjct: 377 STNMCIPASFHCDEESDCPDRSDE----FGCMPPQVVTPPRESIQASRGQTV 424



 Score =  119 bits (298), Expect = 1e-26
 Identities = 65/211 (30%), Positives = 91/211 (43%), Gaps = 52/211 (24%)

Query: 111 RTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGN------------------- 151
           R C   E +C +++ +C+ + +RCD   DC    DE NC                     
Sbjct: 197 RACTEAEFACHSYN-ECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255

Query: 152 ---------------------------ITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSD 184
                                      + C P E  C +G CI R+++C+GQ+DC DGSD
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315

Query: 185 ELDCA-PPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASE 243
           ELDC  PP C  +EF C    C    W CD D DC D++DE+     R   +   C  ++
Sbjct: 316 ELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEV---CGPTQ 372

Query: 244 IQC-GSGECIHKKWRCDGDPDCKDGSDEVNC 273
            +C  +  CI   + CD + DC D SDE  C
Sbjct: 373 FRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403



 Score =  112 bits (279), Expect = 2e-24
 Identities = 66/211 (31%), Positives = 86/211 (40%), Gaps = 55/211 (26%)

Query: 33  CEPSQFQCTN-GRCITLLWKCDGDEDCVDGSDEKNCVKKT-------------------- 71
           C  ++F C +   C+ L ++CD   DC D SDE NC +                      
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRP 258

Query: 72  --------------------------CAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESP 105
                                     C   +  C NG C+P  + CDG  DCEDGSDE  
Sbjct: 259 ETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL- 317

Query: 106 EQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC----GNITCSPDEFTC 161
           +      C  +E  CG  +  C    WRCDG+ DC+   DE NC        C P +F C
Sbjct: 318 DCGPPPPCEPNEFPCG--NGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC 375

Query: 162 -SSGRCISRNFVCNGQDDCSDGSDELDCAPP 191
            S+  CI  +F C+ + DC D SDE  C PP
Sbjct: 376 VSTNMCIPASFHCDEESDCPDRSDEFGCMPP 406



 Score =  110 bits (274), Expect = 7e-24
 Identities = 53/127 (41%), Positives = 67/127 (52%), Gaps = 4/127 (3%)

Query: 26  GTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC-VKKTCAESDFVCNNGQC 84
           G+ R   C P +  C NG CI   + CDG EDC DGSDE +C     C  ++F C NG C
Sbjct: 278 GSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHC 337

Query: 85  VPSRWKCDGDPDCEDGSDES--PEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDS 142
               W+CDGD DCED +DE+  P +     C   +  C   +  CIP S+ CD E+DC  
Sbjct: 338 ALKLWRCDGDFDCEDRTDEANCPTKRPEEVCGPTQFRC-VSTNMCIPASFHCDEESDCPD 396

Query: 143 GEDEENC 149
             DE  C
Sbjct: 397 RSDEFGC 403



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 50/168 (29%), Positives = 66/168 (39%), Gaps = 48/168 (28%)

Query: 230 GRQPVIHTKCPASEIQCGS-GECIHKKWRCDGDPDCKDGSDEVNC--------------- 273
           G  P     C  +E  C S  EC+  ++RCD  PDC+D SDE+NC               
Sbjct: 190 GTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLV 249

Query: 274 --------PSRT-----------------------CRPDQFECEDGSCIHGSRQCNGIRD 302
                   P  T                       C P +  C +G CI     C+G  D
Sbjct: 250 ETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQED 309

Query: 303 CVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
           C DGSDE++C     C  P +F C +G C      C+ + DC D +DE
Sbjct: 310 CEDGSDELDCGPPPPC-EPNEFPCGNGHCALKLWRCDGDFDCEDRTDE 356



 Score = 34.3 bits (77), Expect = 0.50
 Identities = 43/181 (23%), Positives = 58/181 (32%), Gaps = 38/181 (20%)

Query: 83   QC-VPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
            QC  P  ++     DC+ G   +P   ++ TC     SC  HS  C P +  C G   C 
Sbjct: 1125 QCSCPPGYRGPSCQDCDTGYTRTPSGLYLGTCE--RCSCHGHSEACEPETGACQG---CQ 1179

Query: 142  SGEDEENCGNITCSPDEF---------TCSSGRCISRNFVCNGQDDC---SDGSDELD-C 188
               +   C    C P  +          C    C            C   +DG    D C
Sbjct: 1180 HHTEGPRCEQ--CQPGYYGDAQRGTPQDCQLCPCYGDPAAGQAAHTCFLDTDGHPTCDAC 1237

Query: 189  APPTCGAHEFQCST---------SSCI-------PISWVCDDDADCSDQSDESLE-QCGR 231
            +P   G H  +C+            C        PI   CD     S Q D + + QC  
Sbjct: 1238 SPGHSGRHCERCAPGYYGNPSQGQPCQRDSQVPGPIGCNCDPQGSVSSQCDAAGQCQCKA 1297

Query: 232  Q 232
            Q
Sbjct: 1298 Q 1298


>gi|24430141 fibrillin 1 precursor [Homo sapiens]
          Length = 2871

 Score =  118 bits (296), Expect = 2e-26
 Identities = 130/483 (26%), Positives = 183/483 (37%), Gaps = 98/483 (20%)

Query: 32   KCEPSQFQCTNGRCITLL--WKCDGDEDCVDGSDEKNCVK-KTCAESDFVCNNGQCV--P 86
            +C+     CT+G+C   +  +KC  D      S+E+NC     C  S  +C  GQCV  P
Sbjct: 1031 ECKMIPSLCTHGKCRNTIGSFKCRCDSGFALDSEERNCTDIDECRISPDLCGRGQCVNTP 1090

Query: 87   SRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146
              ++C  D   E G         +  C+   + C          S+RC+         + 
Sbjct: 1091 GDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRGGVCHNTEGSYRCECPPGHQLSPNI 1150

Query: 147  ENCGNIT-CSPDEFTCSSGRCISRNFVCNGQDDCSDG----SDELDCAP-PTC----GAH 196
              C +I  C      C +GRC+  N +   Q  C+ G     D L C     C    G  
Sbjct: 1151 SACIDINECELSAHLCPNGRCV--NLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGC 1208

Query: 197  EFQCSTS------SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGE 250
            E  C+ S      SC P   +  D   C+D     +++C   P I          C  G+
Sbjct: 1209 ETFCTNSEGSYECSCQPGFALMPDQRSCTD-----IDECEDNPNI----------CDGGQ 1253

Query: 251  C--IHKKWRC---DGDPDCKDGSDEVN----------CPSRTCRPDQ----FECEDG-SC 290
            C  I  ++RC   DG    +D    V+          C S TC   +      C+ G S 
Sbjct: 1254 CTNIPGEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSG 1313

Query: 291  IHGSRQCNGIRDCVDGSDEVNCKNVNQCLGP-GKFKCRSG--------------ECIDIS 335
              G   C  I +C  G+   NC     C    G FKC                 EC + +
Sbjct: 1314 KKGKTGCTDINECEIGAH--NCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGT 1371

Query: 336  KVCNQEQDCRD-----------------WSDEPLKECHINECLVNNGGCSHICKDLVIGY 378
             +C+Q  DC++                 ++   L EC  N  L  NG C +       GY
Sbjct: 1372 HMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPG----GY 1427

Query: 379  ECDCAAGF-ELIDRKTCGDIDECQNPGICS-QICINLKGGYKCECSRGYQMDLATGVCKA 436
             C+C  GF    D K C DIDEC  P IC    C NL G ++CEC  GY++D + G C  
Sbjct: 1428 RCECDMGFVPSADGKACEDIDECSLPNICVFGTCHNLPGLFRCECEIGYELDRSGGNCTD 1487

Query: 437  VGK 439
            V +
Sbjct: 1488 VNE 1490



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 106/405 (26%), Positives = 163/405 (40%), Gaps = 84/405 (20%)

Query: 78   VCNNGQCVPSR--WKCDGDPDCEDGS--DESPEQC---HMRTC--RIHEISCGAHSTQCI 128
            VC NG CV +R  +KC     C  G   D +   C    + TC  R  +  C       +
Sbjct: 920  VCKNGLCVNTRGSFKCQ----CPSGMTLDATGRICLDIRLETCFLRYEDEEC------TL 969

Query: 129  PVSWRCDGENDCDS------GEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDG 182
            P++ R   +  C S       E+ E C        E  C  G   +   + NG+    D 
Sbjct: 970  PIAGRHRMDACCCSVGAAWGTEECEECPMRNTPEYEELCPRGPGFATKEITNGKPFFKD- 1028

Query: 183  SDELDCAPPTCGAHE-------FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVI 235
             +E    P  C   +       F+C   S   +     ++ +C+D     +++C   P +
Sbjct: 1029 INECKMIPSLCTHGKCRNTIGSFKCRCDSGFALD---SEERNCTD-----IDECRISPDL 1080

Query: 236  HTKCPASEIQCGSGECIHKKWRCDGDPDCK--DGSDE-----VNCPS-RTCRPDQFECED 287
                      CG G+C++      GD +CK  +G +       NC     C+ D   C  
Sbjct: 1081 ----------CGRGQCVNTP----GDFECKCDEGYESGFMMMKNCMDIDECQRDPLLCRG 1126

Query: 288  GSC--IHGSRQCNGIRDCVDG---SDEVN-CKNVNQCLGPGKFKCRSGECIDI----SKV 337
            G C    GS +C    +C  G   S  ++ C ++N+C       C +G C+++       
Sbjct: 1127 GVCHNTEGSYRC----ECPPGHQLSPNISACIDINECELSAHL-CPNGRCVNLIGKYQCA 1181

Query: 338  CNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGD 396
            CN        + + L    I+EC + NGGC   C +    YEC C  GF L+ D+++C D
Sbjct: 1182 CNPGYHS---TPDRLFCVDIDECSIMNGGCETFCTNSEGSYECSCQPGFALMPDQRSCTD 1238

Query: 397  IDECQ-NPGIC-SQICINLKGGYKCECSRGYQMDLATGVCKAVGK 439
            IDEC+ NP IC    C N+ G Y+C C  G+        C  V +
Sbjct: 1239 IDECEDNPNICDGGQCTNIPGEYRCLCYDGFMASEDMKTCVDVNE 1283



 Score = 93.6 bits (231), Expect = 7e-19
 Identities = 113/451 (25%), Positives = 168/451 (37%), Gaps = 62/451 (13%)

Query: 32   KCEPSQFQCTNGRCITLL--WKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS-- 87
            +C+       N  CI     ++CD        S  +   +  C E   +C++GQC+ +  
Sbjct: 1811 ECQNGPVCQRNAECINTAGSYRCDCKPGYRFTSTGQCNDRNECQEIPNICSHGQCIDTVG 1870

Query: 88   RWKC---------DGDPDCEDGSDESPEQCHMRTCR--IHEISCG-------AHSTQCIP 129
             + C         D    C D ++   + C   TCR  I   +C        +H+  CI 
Sbjct: 1871 SFYCLCHTGFKTNDDQTMCLDINECERDACGNGTCRNTIGSFNCRCNHGFILSHNNDCID 1930

Query: 130  VSWRCDGE-NDCDSGEDEENCGNITC--------SPDEFTCSS-GRCISRNFVCN-GQDD 178
            V     G  N C +G+     G+  C        +PD  TC     C+     C  G   
Sbjct: 1931 VDECASGNGNLCRNGQCINTVGSFQCQCNEGYEVAPDGRTCVDINECLLEPRKCAPGTCQ 1990

Query: 179  CSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVC--------DDDADCSDQSDESLEQCG 230
              DGS    C P     +E       C+    +C        +    C      SL   G
Sbjct: 1991 NLDGSYRCICPPGYSLQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSG 2050

Query: 231  R--QPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDG--SDEVNCPSRTCRPDQFECE 286
            R  Q +  + C A   +   G+C   K R     +C      +    P   C  +  E  
Sbjct: 2051 RRCQDLRMSYCYA---KFEGGKCSSPKSRNHSKQECCCALKGEGWGDPCELCPTEPDEAF 2107

Query: 287  DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRD 346
               C +GS    G  D     DE  CK  + C        + G+CI+     +   +C  
Sbjct: 2108 RQICPYGSGIIVGPDDSAVDMDE--CKEPDVC--------KHGQCINTDG--SYRCECPF 2155

Query: 347  WSDEPLKEC-HINECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDEC-QNPG 404
                   EC   +EC V N   +  CK+++ G+EC C  GFE     TC DI+EC QNP 
Sbjct: 2156 GYILAGNECVDTDECSVGNPCGNGTCKNVIGGFECTCEEGFEPGPMMTCEDINECAQNPL 2215

Query: 405  ICSQICINLKGGYKCECSRGYQMDLATGVCK 435
            +C+  C+N  G Y+C+C  GY +     +CK
Sbjct: 2216 LCAFRCVNTYGSYECKCPVGYVLREDRRMCK 2246



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 124/514 (24%), Positives = 187/514 (36%), Gaps = 122/514 (23%)

Query: 30   KAKCEPSQF----QCTN-GRCITLLWKCDGDEDCVDGSDEKNCVKKT------------- 71
            K  C P       +CT+   C      C    DC +      C+ K              
Sbjct: 1347 KCSCSPGWIGDGIKCTDLDECSNGTHMCSQHADCKNTMGSYRCLCKEGYTGDGFTCTDLD 1406

Query: 72   -CAESDFVCNNGQCV--PSRWKCDGD----PDCEDGSDESPEQCHMRTCRIHEISCGAHS 124
             C+E+  +C NGQC+  P  ++C+ D    P  +  + E  ++C +         C   +
Sbjct: 1407 ECSENLNLCGNGQCLNAPGGYRCECDMGFVPSADGKACEDIDECSLPNI------CVFGT 1460

Query: 125  TQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISR--NFVCN-------- 174
               +P  +RC+ E   +      NC ++    D  TC SG C++   +++C+        
Sbjct: 1461 CHNLPGLFRCECEIGYELDRSGGNCTDVNECLDPTTCISGNCVNTPGSYICDCPPDFELN 1520

Query: 175  ----GQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCG 230
                G  D   G+  LD  P      +  CS    + +S      + C          C 
Sbjct: 1521 PTRVGCVDTRSGNCYLDIRPRGDNG-DTACSNEIGVGVSKA----SCCCSLGKAWGTPCE 1575

Query: 231  RQPVIHTK-----CPASE---------IQCGSGECIHKKWRCDGDPDCKD-GSDEVNCPS 275
              P ++T      CP  E         I     EC      C G       GS +  CP+
Sbjct: 1576 MCPAVNTSEYKILCPGGEGFRPNPITVILEDIDECQELPGLCQGGKCINTFGSFQCRCPT 1635

Query: 276  --------RTCRPDQFECED------GSCIH--GSRQC---------NGIRDCVDGSDEV 310
                    R C  D  ECE       G+C +  G+  C         NG  +C+D    +
Sbjct: 1636 GYYLNEDTRVC-DDVNECETPGICGPGTCYNTVGNYTCICPPDYMQVNGGNNCMDMRRSL 1694

Query: 311  NCKNV---NQ-CLGPGKFKCRSGECI---DISKVCNQ--EQDCRDWSDEPLKEC------ 355
              +N    NQ C G   F      C    +I +  N+  EQ     +DE    C      
Sbjct: 1695 CYRNYYADNQTCDGELLFNMTKKMCCCSYNIGRAWNKPCEQCPIPSTDEFATLCGSQRPG 1754

Query: 356  -----------HINECLVNNGGCSH-ICKDLVIGYECDCAAGFELIDRK-TCGDIDECQN 402
                        I+EC    G C + +C ++V  + C+C  GF   D+   C DIDECQN
Sbjct: 1755 FVIDIYTGLPVDIDECREIPGVCENGVCINMVGSFRCECPVGFFYNDKLLVCEDIDECQN 1814

Query: 403  PGICSQ--ICINLKGGYKCECSRGYQMDLATGVC 434
              +C +   CIN  G Y+C+C  GY+   +TG C
Sbjct: 1815 GPVCQRNAECINTAGSYRCDCKPGYRF-TSTGQC 1847



 Score = 87.8 bits (216), Expect = 4e-17
 Identities = 113/428 (26%), Positives = 159/428 (37%), Gaps = 92/428 (21%)

Query: 40  CTNGRCITLLWKCDGDEDCVD------GSDEKNCVKKTCAESDFVCNNGQCVPS--RWKC 91
           C NG CI      DG   C+        SD + C      E+  +C NG+CV +   ++C
Sbjct: 582 CLNGMCINE----DGSFKCICKPGFQLASDGRYCKDINECETPGICMNGRCVNTDGSYRC 637

Query: 92  DGDPDCEDGSDESP-EQCHMRTCRIHEISC--GAHSTQCIPVSWRCDGENDCDSGEDEEN 148
           +  P    G D       HMR+      +C  G    QCI   +    +++C     E  
Sbjct: 638 ECFPGLAVGLDGRVCVDTHMRS------TCYGGYKRGQCIKPLFGAVTKSECCCASTEYA 691

Query: 149 CGNITCSPDEFTCSSGRCISRNFVCN-GQDDCSDGSDELDCA--PPTC--GAHEFQCSTS 203
            G   C P    C +        +C+ G    S GSD  +CA  P  C  G  E    T 
Sbjct: 692 FGE-PCQP----CPAQNSAEYQALCSSGPGMTSAGSDINECALDPDICPNGICENLRGTY 746

Query: 204 SCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPD 263
            CI           C+  S   ++  G+  V   +C  + + C +G+C +          
Sbjct: 747 KCI-----------CN--SGYEVDSTGKNCVDINECVLNSLLCDNGQCRNTP-------- 785

Query: 264 CKDGSDEVNCPSRTC-RPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPG 322
              GS    CP     +PD   CED      S   NG+           CKN      PG
Sbjct: 786 ---GSFVCTCPKGFIYKPDLKTCEDIDECESSPCINGV-----------CKN-----SPG 826

Query: 323 KF--KCRSGECIDISK-VCNQEQDCRDWSDEPLKECHINECLVNNGGC--SHICKDL--V 375
            F  +C S   +D +K +C +      W       C IN     NG    S  C  L   
Sbjct: 827 SFICECSSESTLDPTKTICIETIKGTCWQTVIDGRCEINI----NGATLKSQCCSSLGAA 882

Query: 376 IGYECD-------CAAGFELIDRKTCGDIDECQ-NPGICSQ-ICINLKGGYKCECSRGYQ 426
            G  C        C  G+  I    C DIDEC+  PG+C   +C+N +G +KC+C  G  
Sbjct: 883 WGSPCTLCQVDPICGKGYSRIKGTQCEDIDECEVFPGVCKNGLCVNTRGSFKCQCPSGMT 942

Query: 427 MDLATGVC 434
           +D    +C
Sbjct: 943 LDATGRIC 950



 Score = 84.7 bits (208), Expect = 3e-16
 Identities = 108/460 (23%), Positives = 171/460 (37%), Gaps = 90/460 (19%)

Query: 40   CTNGRCITL--LWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQC--VPSRWKCDGDP 95
            C +G+CI     ++C+     +   +E  CV          C NG C  V   ++C    
Sbjct: 2137 CKHGQCINTDGSYRCECPFGYILAGNE--CVDTDECSVGNPCGNGTCKNVIGGFECT--- 2191

Query: 96   DCEDGSDESPEQC--HMRTCRIHEISC--------GAHSTQCIPVSW-------RCDGEN 138
             CE+G +  P      +  C  + + C        G++  +C PV +        C  E+
Sbjct: 2192 -CEEGFEPGPMMTCEDINECAQNPLLCAFRCVNTYGSYECKC-PVGYVLREDRRMCKDED 2249

Query: 139  DCDSG-----EDEENCGNIT------CSPDEFTCSSGR-CISRNFVCNGQDDCSDGSDEL 186
            +C+ G     E +  C N+       C P       G  C+  N        C +G    
Sbjct: 2250 ECEEGKHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGR--- 2306

Query: 187  DCAPPTCGAHEFQCSTS-SCIPISWVCDDDAD--CSDQSDESLEQCG---RQPVIHTKC- 239
                 T G++  +C+   +  P    C D+ +  C  +  +++ Q G   R PV  ++C 
Sbjct: 2307 --CLNTRGSYTCECNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVTKSECC 2364

Query: 240  --------PASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCI 291
                    P  EI    G    KK    G     +G+D        C+     C +G C+
Sbjct: 2365 CDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMTNGAD-----IDECKVIHDVCRNGECV 2419

Query: 292  H--GSRQC---NGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGEC---IDISKVCNQEQD 343
            +  GS  C    G    + G+  V+    NQ   P  F C++ E        K    ++D
Sbjct: 2420 NDRGSYHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKGYILQED 2479

Query: 344  CRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGF-----ELIDRKTC-GDI 397
             R   D       ++EC      C  +C + + G+ C C  GF       ID   C  DI
Sbjct: 2480 GRSCKD-------LDECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTSCIDNNECTSDI 2532

Query: 398  DECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAV 437
            + C + GIC     N  G + CEC RG+ +D     C+ V
Sbjct: 2533 NLCGSKGICQ----NTPGSFTCECQRGFSLDQTGSSCEDV 2568



 Score = 82.0 bits (201), Expect = 2e-15
 Identities = 118/524 (22%), Positives = 190/524 (36%), Gaps = 146/524 (27%)

Query: 32   KCEPSQFQCTNGRCITLLWK-----------------CDGDEDC--VDGSDEKNCVKKTC 72
            +CE S   C NGRC+ L+ K                 C   ++C  ++G  E  C   T 
Sbjct: 1158 ECELSAHLCPNGRCVNLIGKYQCACNPGYHSTPDRLFCVDIDECSIMNGGCETFC---TN 1214

Query: 73   AESDFVCN---NGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIP 129
            +E  + C+       +P +  C    +CED    +P  C    C              IP
Sbjct: 1215 SEGSYECSCQPGFALMPDQRSCTDIDECED----NPNICDGGQCTN------------IP 1258

Query: 130  VSWRCDGENDCDSGEDEENCGNIT-CSPDEFTCSSGRCISR--NFVCN---------GQD 177
              +RC   +   + ED + C ++  C  +   C SG C +   +F+C+         G+ 
Sbjct: 1259 GEYRCLCYDGFMASEDMKTCVDVNECDLNPNICLSGTCENTKGSFICHCDMGYSGKKGKT 1318

Query: 178  DCSDGSDELDCAPPTCGAH--------EFQCSTS--------------SCIPISWVCDDD 215
             C+D  +E +     CG H         F+CS S               C   + +C   
Sbjct: 1319 GCTD-INECEIGAHNCGKHAVCTNTAGSFKCSCSPGWIGDGIKCTDLDECSNGTHMCSQH 1377

Query: 216  ADCSDQSDESLEQC-------GRQPVIHTKCPASEIQCGSGECIHKK--WRCDGDPDCKD 266
            ADC +        C       G       +C  +   CG+G+C++    +RC+ D     
Sbjct: 1378 ADCKNTMGSYRCLCKEGYTGDGFTCTDLDECSENLNLCGNGQCLNAPGGYRCECDMGFVP 1437

Query: 267  GSDEVNCPSRTCRPDQFECE-DGSCIHGSRQCNGIRDCVDGSDEV---------NCKNVN 316
             +D   C       D  EC     C+ G+  C+ +        E+         NC +VN
Sbjct: 1438 SADGKACE------DIDECSLPNICVFGT--CHNLPGLFRCECEIGYELDRSGGNCTDVN 1489

Query: 317  QCLGPGKFKCRSGECIDI--SKVCNQEQDCR------DWSDEPLKECHINECLVNNGGCS 368
            +CL P    C SG C++   S +C+   D           D     C+++     + G +
Sbjct: 1490 ECLDPTT--CISGNCVNTPGSYICDCPPDFELNPTRVGCVDTRSGNCYLDIRPRGDNGDT 1547

Query: 369  HICKDLVIGYE---CDCAAG-----------------FELIDRKTCG-----------DI 397
                ++ +G     C C+ G                 ++++     G           DI
Sbjct: 1548 ACSNEIGVGVSKASCCCSLGKAWGTPCEMCPAVNTSEYKILCPGGEGFRPNPITVILEDI 1607

Query: 398  DECQN-PGICSQ-ICINLKGGYKCECSRGYQMDLATGVCKAVGK 439
            DECQ  PG+C    CIN  G ++C C  GY ++  T VC  V +
Sbjct: 1608 DECQELPGLCQGGKCINTFGSFQCRCPTGYYLNEDTRVCDDVNE 1651



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 103/431 (23%), Positives = 154/431 (35%), Gaps = 104/431 (24%)

Query: 52   CDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMR 111
            C      + G D+       C E D VC +GQC+ +    DG   CE             
Sbjct: 2111 CPYGSGIIVGPDDSAVDMDECKEPD-VCKHGQCINT----DGSYRCE------------- 2152

Query: 112  TCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNF 171
             C    I  G    +C+     C   N C +G  +   G   C     TC  G       
Sbjct: 2153 -CPFGYILAG---NECVDTD-ECSVGNPCGNGTCKNVIGGFEC-----TCEEGFEPGPMM 2202

Query: 172  VCNGQDDCSDGSDELDCA---PPTCGAHEFQCSTSSCIPISWV-------CDDDADCSDQ 221
             C   ++C+   + L CA     T G++E +C      P+ +V       C D+ +C + 
Sbjct: 2203 TCEDINECAQ--NPLLCAFRCVNTYGSYECKC------PVGYVLREDRRMCKDEDECEEG 2254

Query: 222  SDESLEQ--------------CG----RQP-----VIHTKCPASEIQCGSGECIHKK--W 256
              +  E+              CG    R+P     V   +C      C +G C++ +  +
Sbjct: 2255 KHDCTEKQMECKNLIGTYMCICGPGYQRRPDGEGCVDENECQTKPGICENGRCLNTRGSY 2314

Query: 257  RCDGDPDCKDGSDEVNCPSRTCRPDQFECED---GSCIHGSRQCNGIRDCVDGSDEVNCK 313
             C+    C DG         T  P+Q EC D   G C     Q      C  GS   N  
Sbjct: 2315 TCE----CNDGF--------TASPNQDECLDNREGYCFTEVLQ----NMCQIGSSNRNPV 2358

Query: 314  NVNQCL-------GPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECHINECLVNNGG 366
              ++C        GP    C     +   K+C   +     +   + EC +   +  NG 
Sbjct: 2359 TKSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGRGFMT-NGADIDECKVIHDVCRNGE 2417

Query: 367  CSHICKDLVIGYECDCAAGFEL-IDRKTCGDIDEC-QNPGICSQICINLKGGYKCECSRG 424
            C +        Y C C  G+   I   +C D++EC Q P  C+ IC N +G Y+C C +G
Sbjct: 2418 CVNDRGS----YHCICKTGYTPDITGTSCVDLNECNQAPKPCNFICKNTEGSYQCSCPKG 2473

Query: 425  YQMDLATGVCK 435
            Y +      CK
Sbjct: 2474 YILQEDGRSCK 2484



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 112/452 (24%), Positives = 167/452 (36%), Gaps = 94/452 (20%)

Query: 32   KCEPSQFQCTNGR--CITLLWKCDGDEDCVDGS------DEKNCVKKT-CAESDFVCNNG 82
            +CE  +  CT  +  C  L+    G   C+ G       D + CV +  C     +C NG
Sbjct: 2250 ECEEGKHDCTEKQMECKNLI----GTYMCICGPGYQRRPDGEGCVDENECQTKPGICENG 2305

Query: 83   QCVPSR--WKCDGDPDCEDGSDESPEQCHMRTCR-------IHEISCGAHSTQCIPVSWR 133
            +C+ +R  + C+    C DG   SP Q      R       + +  C   S+   PV+  
Sbjct: 2306 RCLNTRGSYTCE----CNDGFTASPNQDECLDNREGYCFTEVLQNMCQIGSSNRNPVT-- 2359

Query: 134  CDGENDCDSGEDE----ENCGNITCSPDEFTCSSGRCISRNFVCNGQD--DCSDGSDELD 187
               E  CD G       E C        +  C  GR     F+ NG D  +C    D   
Sbjct: 2360 -KSECCCDGGRGWGPHCEICPFQGTVAFKKLCPHGR----GFMTNGADIDECKVIHDV-- 2412

Query: 188  CAPPTC----GAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQP-----VIHTK 238
            C    C    G++   C T     I+        C D     L +C + P     +    
Sbjct: 2413 CRNGECVNDRGSYHCICKTGYTPDIT-----GTSCVD-----LNECNQAPKPCNFICKNT 2462

Query: 239  CPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCP--------SRTCR-PDQFECEDGS 289
              + +  C  G  + +  R   D D +  + + NC           TC+ P  F     S
Sbjct: 2463 EGSYQCSCPKGYILQEDGRSCKDLD-ECATKQHNCQFLCVNTIGGFTCKCPPGFTQHHTS 2521

Query: 290  CIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSD 349
            CI  +   + I  C  GS  + C+N      PG F C   EC     +      C D   
Sbjct: 2522 CIDNNECTSDINLC--GSKGI-CQNT-----PGSFTC---ECQRGFSLDQTGSSCED--- 2567

Query: 350  EPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGF-ELIDRKTCGDIDECQNPGICSQ 408
                   ++EC   N  C H C++++ GY C C  G+ +      C D +EC +  IC  
Sbjct: 2568 -------VDEC-EGNHRCQHGCQNIIGGYRCSCPQGYLQHYQWNQCVDENECLSAHICGG 2619

Query: 409  I-CINLKGGYKCECSRGYQMDLATGVCKAVGK 439
              C N  G YKC C  G+Q +  +G C+ + +
Sbjct: 2620 ASCHNTLGSYKCMCPAGFQYEQFSGGCQDINE 2651



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 103/441 (23%), Positives = 158/441 (35%), Gaps = 87/441 (19%)

Query: 33  CEPSQFQCTNGRCITLLWKC----------DGDEDCVDGSDEKNCVKKTCAESDFVCNNG 82
           C+  ++ C NGRCI     C          D   +C+D  +   C K  CA  + + N G
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRCECNKGFQLDLRGECIDVDE---CEKNPCAGGECINNQG 509

Query: 83  ----------QCVPSRWKCDGDPDC-EDGSDESPEQCHMRTCRIHEI-SCGAHSTQ---- 126
                     Q   +R +C    +C ++G   +  +C       H + + G H T+    
Sbjct: 510 SYTCQCRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGFHVTRDGKN 569

Query: 127 CIPVSWRCDGENDCDSGE--DEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSD 184
           C  +   C   N C +G   +E+      C P     S GR       C     C +G  
Sbjct: 570 CEDMD-ECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPGICMNGR- 627

Query: 185 ELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEI 244
                  T G++  +C     + +     D   C D    S    G +            
Sbjct: 628 ----CVNTDGSYRCECFPGLAVGL-----DGRVCVDTHMRSTCYGGYK------------ 666

Query: 245 QCGSGECIHKKWRCDGDPDCKDGSDEVN-------CPSRTCRPDQFECEDGSCIHGSRQC 297
               G+CI   +      +C   S E         CP++     Q  C  G  +  +   
Sbjct: 667 ---RGQCIKPLFGAVTKSECCCASTEYAFGEPCQPCPAQNSAEYQALCSSGPGMTSAG-- 721

Query: 298 NGIRDCVDGSDEVN---CKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKE 354
           + I +C    D      C+N+    G  K  C SG  +D     +  ++C D     + E
Sbjct: 722 SDINECALDPDICPNGICENLR---GTYKCICNSGYEVD-----STGKNCVD-----INE 768

Query: 355 CHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDECQNPGICSQICINL 413
           C +N  L +NG C +     V    C C  GF    D KTC DIDEC++    + +C N 
Sbjct: 769 CVLNSLLCDNGQCRNTPGSFV----CTCPKGFIYKPDLKTCEDIDECESSPCINGVCKNS 824

Query: 414 KGGYKCECSRGYQMDLATGVC 434
            G + CECS    +D    +C
Sbjct: 825 PGSFICECSSESTLDPTKTIC 845



 Score = 71.2 bits (173), Expect = 4e-12
 Identities = 64/197 (32%), Positives = 91/197 (46%), Gaps = 25/197 (12%)

Query: 278 CRPDQFECEDGSCIH--GSRQCNGIRDCVDGSD---EVNCKNVNQCLGPGKFKCRSGECI 332
           C+  ++ C++G CI   GS +C    +C  G        C +V++C    K  C  GECI
Sbjct: 453 CQLVRYLCQNGRCIPTPGSCRC----ECNKGFQLDLRGECIDVDEC---EKNPCAGGECI 505

Query: 333 DI--SKVCNQEQDCRDWSDEPLK--ECH-INECLVNNGGCSH-ICKDLVIGYECDCAAGF 386
           +   S  C     CR      L   EC  I+ECL N   C++  C +    + C C AGF
Sbjct: 506 NNQGSYTCQ----CRAGYQSTLTRTECRDIDECLQNGRICNNGRCINTDGSFHCVCNAGF 561

Query: 387 ELI-DRKTCGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVCKAVGK-EPSL 443
            +  D K C D+DEC    +C + +CIN  G +KC C  G+Q+      CK + + E   
Sbjct: 562 HVTRDGKNCEDMDECSIRNMCLNGMCINEDGSFKCICKPGFQLASDGRYCKDINECETPG 621

Query: 444 IFTNRRDIRKIGLERKE 460
           I  N R +   G  R E
Sbjct: 622 ICMNGRCVNTDGSYRCE 638



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 54/219 (24%), Positives = 79/219 (36%), Gaps = 33/219 (15%)

Query: 240 PASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDG-SCIHGSRQCN 298
           P     CG G C      C     C  G    +C SR+ +     C +G SC      C 
Sbjct: 83  PICRHSCGDGFCSRPNM-CT----CPSGQIAPSCGSRSIQHCNIRCMNGGSCSDDHCLCQ 137

Query: 299 GI---RDCVDGSDEVNCKNVNQCLGPGKFKC-------------RSGECIDISKVCNQEQ 342
                  C     E  C N  +C+ P +  C             R+G C  +       Q
Sbjct: 138 KGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQCERDYRTGPCFTVIS----NQ 193

Query: 343 DCRDWSDEPLKECHINECLVNNGGC-SHICKDLVIGYECDCAAGF-ELIDRKTCGDIDEC 400
            C+      +  C    C    G    H C ++       C  GF   I    C D+DEC
Sbjct: 194 MCQGQLSGIV--CTKTLCCATVGRAWGHPC-EMCPAQPHPCRRGFIPNIRTGACQDVDEC 250

Query: 401 QN-PGICSQ-ICINLKGGYKCECSRGYQMDLATGVCKAV 437
           Q  PG+C    CIN  G ++C+C  G++++  +  C+ +
Sbjct: 251 QAIPGLCQGGNCINTVGSFECKCPAGHKLNEVSQKCEDI 289



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 80/313 (25%), Positives = 104/313 (33%), Gaps = 61/313 (19%)

Query: 120 CGA-HSTQCIPVSWRCDGENDCDSGEDEENCGNITCS-PDEFTCSSGR----CISR---- 169
           CG+ ++  C P      G N C       +CG+  CS P+  TC SG+    C SR    
Sbjct: 59  CGSRYNAYCCPGWKTLPGGNQCIVPICRHSCGDGFCSRPNMCTCPSGQIAPSCGSRSIQH 118

Query: 170 -NFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQ 228
            N  C     CSD  D   C     G H  Q    S       C     C+     +  Q
Sbjct: 119 CNIRCMNGGSCSD--DHCLCQKGYIGTHCGQPVCESGCLNGGRCVAPNRCACTYGFTGPQ 176

Query: 229 CGRQ--------PVIHTKCPA--SEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRT- 277
           C R          + +  C    S I C    C     R  G P C+       CP++  
Sbjct: 177 CERDYRTGPCFTVISNQMCQGQLSGIVCTKTLCCATVGRAWGHP-CE------MCPAQPH 229

Query: 278 -CRPDQF-ECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDIS 335
            CR         G+C     +C  I     G + +N     +C      KC +G      
Sbjct: 230 PCRRGFIPNIRTGAC-QDVDECQAIPGLCQGGNCINTVGSFEC------KCPAGH----- 277

Query: 336 KVCNQEQDCRDWSDEPLKECHINECLVNNGGCSH-ICKDLVIGYECDCAAGFELI-DRKT 393
           K+    Q C D          I+EC    G C    C + V  Y C C  GF    D   
Sbjct: 278 KLNEVSQKCED----------IDECSTIPGICEGGECTNTVSSYFCKCPPGFYTSPDGTR 327

Query: 394 CGDIDECQNPGIC 406
           C D+     PG C
Sbjct: 328 CIDV----RPGYC 336



 Score = 35.0 bits (79), Expect = 0.29
 Identities = 13/39 (33%), Positives = 22/39 (56%), Gaps = 6/39 (15%)

Query: 715  CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
            C ++C       +    Y CSCP GY ++E+GR C+ ++
Sbjct: 2455 CNFIC------KNTEGSYQCSCPKGYILQEDGRSCKDLD 2487



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 19/56 (33%), Positives = 27/56 (48%), Gaps = 3/56 (5%)

Query: 698 VQPSGKNWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
           V   GKN   EDM+      +CL    IN+    + C C  G+ +  +GR C+ IN
Sbjct: 563 VTRDGKNC--EDMDECSIRNMCLNGMCINEDG-SFKCICKPGFQLASDGRYCKDIN 615



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 14/54 (25%), Positives = 29/54 (53%), Gaps = 8/54 (14%)

Query: 710  MENGGCEYL--CLPAPQI------NDHSPKYTCSCPSGYNVEENGRDCQRINVT 755
            ++N  CE +  C+  P+I      ++    + C CP G+++  +GR CQ + ++
Sbjct: 2006 LQNEKCEDIDECVEEPEICALGTCSNTEGSFKCLCPEGFSLSSSGRRCQDLRMS 2059



 Score = 30.4 bits (67), Expect = 7.2
 Identities = 11/22 (50%), Positives = 14/22 (63%)

Query: 732 YTCSCPSGYNVEENGRDCQRIN 753
           Y C C SGY V+  G++C  IN
Sbjct: 746 YKCICNSGYEVDSTGKNCVDIN 767



 Score = 30.4 bits (67), Expect = 7.2
 Identities = 12/50 (24%), Positives = 24/50 (48%), Gaps = 6/50 (12%)

Query: 704  NWCEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
            N C  D+   G + +C   P        +TC C  G+++++ G  C+ ++
Sbjct: 2526 NECTSDINLCGSKGICQNTPG------SFTCECQRGFSLDQTGSSCEDVD 2569



 Score = 30.0 bits (66), Expect = 9.4
 Identities = 14/42 (33%), Positives = 19/42 (45%), Gaps = 6/42 (14%)

Query: 712  NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
            NGGCE  C       +    Y CSC  G+ +  + R C  I+
Sbjct: 1205 NGGCETFC------TNSEGSYECSCQPGFALMPDQRSCTDID 1240


>gi|66346695 fibrillin 2 precursor [Homo sapiens]
          Length = 2912

 Score =  108 bits (271), Expect = 2e-23
 Identities = 112/459 (24%), Positives = 169/459 (36%), Gaps = 60/459 (13%)

Query: 32   KCEPSQFQCTNGRCITLL--WKCDGDEDCVDGSDEKNCVK-KTCAESDFVCNNGQCV--P 86
            +C+     CT G+C   +  +KC  +       +E+NC     C  S  +C +G CV  P
Sbjct: 1076 ECKAFPGMCTYGKCRNTIGSFKCRCNSGFALDMEERNCTDIDECRISPDLCGSGICVNTP 1135

Query: 87   SRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDE 146
              ++C+     E G         +  C  + + C   +      S++CD     +     
Sbjct: 1136 GSFECECFEGYESGFMMMKNCMDIDECERNPLLCRGGTCVNTEGSFQCDCPLGHELSPSR 1195

Query: 147  ENCGNIT-CSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSC 205
            E+C +I  CS  +  C +G+C+  N +   Q  C+ G              E       C
Sbjct: 1196 EDCVDINECSLSDNLCRNGKCV--NMIGTYQCSCNPGYQATPDRQGCTDIDECMIMNGGC 1253

Query: 206  IPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGEC--IHKKWRC---DG 260
                   +   +CS     +L   GR      +C  +   C  G+C  I  ++RC   DG
Sbjct: 1254 DTQCTNSEGSYECSCSEGYALMPDGRSCADIDECENNPDICDGGQCTNIPGEYRCLCYDG 1313

Query: 261  ---DPDCKDGSDEVNCP--SRTCRPDQFECEDGSCI----------HGSRQCNGIRDCVD 305
                 D K   D   C   S  C   + E   GS I           G+  C  + +C  
Sbjct: 1314 FMASMDMKTCIDVNECDLNSNICMFGECENTKGSFICHCQLGYSVKKGTTGCTDVDECEI 1373

Query: 306  GSDEVNCKNVNQCLG-PGKFKCRSGE--------CIDISKVCNQEQDC------------ 344
            G+   NC     CL  PG FKC   E        CID+ +  N    C            
Sbjct: 1374 GAH--NCDMHASCLNIPGSFKCSCREGWIGNGIKCIDLDECSNGTHQCSINAQCVNTPGS 1431

Query: 345  ------RDWSDEPLKECHINECLVNNGGCSH-ICKDLVIGYECDCAAGFE-LIDRKTCGD 396
                    ++ +      ++EC  N   C +  C ++   Y C+C  GF    D ++C D
Sbjct: 1432 YRCACSEGFTGDGFTCSDVDECAENINLCENGQCLNVPGAYRCECEMGFTPASDSRSCQD 1491

Query: 397  IDECQNPGICS-QICINLKGGYKCECSRGYQMDLATGVC 434
            IDEC    IC    C NL G + C C  GY++D   G C
Sbjct: 1492 IDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNC 1530



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 106/404 (26%), Positives = 158/404 (39%), Gaps = 92/404 (22%)

Query: 78   VCNNGQCVPSRWKCDGDPDCE-------DGS-----DESPEQCHMRTCR---IHEISCGA 122
            VC NG+CV S+    G   CE       DG+     D   EQC+++      IH +    
Sbjct: 965  VCPNGRCVNSK----GSFHCECPEGLTLDGTGRVCLDIRMEQCYLKWDEDECIHPVPGKF 1020

Query: 123  HSTQC---IPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCIS-RNFVCNGQDD 178
                C   +  +W          G + E C        E  C  G   + R  V  G+  
Sbjct: 1021 RMDACCCAVGAAW----------GTECEECPKPGTKEYETLCPRGAGFANRGDVLTGRPF 1070

Query: 179  CSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTK 238
              D ++        C A    C+   C            C   S  +L+   R      +
Sbjct: 1071 YKDINE--------CKAFPGMCTYGKCRNTI----GSFKCRCNSGFALDMEERNCTDIDE 1118

Query: 239  CPASEIQCGSGECIHK--KWRCDGDPDCKDGSDE-----VNCPS-RTCRPDQFECEDGSC 290
            C  S   CGSG C++    + C+    C +G +       NC     C  +   C  G+C
Sbjct: 1119 CRISPDLCGSGICVNTPGSFECE----CFEGYESGFMMMKNCMDIDECERNPLLCRGGTC 1174

Query: 291  IH--GSRQCNGIRDCVDGSD----EVNCKNVNQCLGPGKFKCRSGECIDISKV----CN- 339
            ++  GS QC    DC  G +      +C ++N+C       CR+G+C+++       CN 
Sbjct: 1175 VNTEGSFQC----DCPLGHELSPSREDCVDINECSLSDNL-CRNGKCVNMIGTYQCSCNP 1229

Query: 340  ------QEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRK 392
                    Q C D          I+EC++ NGGC   C +    YEC C+ G+ L+ D +
Sbjct: 1230 GYQATPDRQGCTD----------IDECMIMNGGCDTQCTNSEGSYECSCSEGYALMPDGR 1279

Query: 393  TCGDIDECQ-NPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
            +C DIDEC+ NP IC    C N+ G Y+C C  G+   +    C
Sbjct: 1280 SCADIDECENNPDICDGGQCTNIPGEYRCLCYDGFMASMDMKTC 1323



 Score = 83.6 bits (205), Expect = 7e-16
 Identities = 116/496 (23%), Positives = 172/496 (34%), Gaps = 116/496 (23%)

Query: 40   CTNGRCITLL--WKCDGDEDCVDGSDEKNCVK-KTCAESDFVC--------NNGQCV-PS 87
            C NG C  ++  ++C+ +E    G    NC     CA++  +C         + +C  P 
Sbjct: 2223 CGNGTCTNVIGSFECNCNEGFEPGP-MMNCEDINECAQNPLLCAFRCMNTFGSYECTCPI 2281

Query: 88   RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC----GAHSTQCIP-VSWRCDGENDCDS 142
             +    D       DE  E  H   C    + C    G     C P ++ R DGE   D 
Sbjct: 2282 GYALREDQKMCKDLDECAEGLH--DCESRGMMCKNLIGTFMCICPPGMARRPDGEGCVDE 2339

Query: 143  GEDEENCGNITCSPDEFTCSSGRCI----SRNFVCN-GQDDCSDGSDELDCAPPTCGAHE 197
             E         C      C +GRC+    S    CN G    S G++ LD     C A  
Sbjct: 2340 NE---------CRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFAEV 2390

Query: 198  FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHT-------------------- 237
             Q           +      C D       QC   P+  T                    
Sbjct: 2391 LQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGRDI 2450

Query: 238  -KCPASEIQCGSGECIHK--KWRCDGDPDCKDGSD---------EVNCPSRTCRPDQFEC 285
             +C      C +G+CI+    +RC     CK G           +++  S++ +P  + C
Sbjct: 2451 DECKVMPNLCTNGQCINTMGSFRCF----CKVGYTTDISGTSCIDLDECSQSPKPCNYIC 2506

Query: 286  EDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQC--------------LGPGKFKCRSG-- 329
            ++     GS QC+  R  V   D   CK++++C              LG    KC  G  
Sbjct: 2507 KN---TEGSYQCSCPRGYVLQEDGKTCKDLDECQTKQHNCQFLCVNTLGGFTCKCPPGFT 2563

Query: 330  ----------ECIDISKVCNQEQDCRDWSDEPLKECH--------------INECLVNNG 365
                      EC     +C  +  C++       EC               ++EC   N 
Sbjct: 2564 QHHTACIDNNECGSQPSLCGAKGICQNTPGSFSCECQRGFSLDATGLNCEDVDEC-DGNH 2622

Query: 366  GCSHICKDLVIGYECDCAAGF-ELIDRKTCGDIDECQNPGIC-SQICINLKGGYKCECSR 423
             C H C++++ GY C C  G+ +      C D +EC NP  C S  C N  G YKC C  
Sbjct: 2623 RCQHGCQNILGGYRCGCPQGYIQHYQWNQCVDENECSNPNACGSASCYNTLGSYKCACPS 2682

Query: 424  GYQMDLATGVCKAVGK 439
            G+  D  +  C  V +
Sbjct: 2683 GFSFDQFSSACHDVNE 2698



 Score = 82.4 bits (202), Expect = 2e-15
 Identities = 114/459 (24%), Positives = 168/459 (36%), Gaps = 85/459 (18%)

Query: 32   KCEPSQFQCTNGRCITLLWKCDGDEDCVDGS------DEKNCVKKTCAESDFVCNNGQCV 85
            +C  +   C NGRC+      DG   C+  +      D KNCV      +  +C NG C+
Sbjct: 578  ECIQNGVLCKNGRCVNT----DGSFQCICNAGFELTTDGKNCVDHDECTTTNMCLNGMCI 633

Query: 86   --PSRWKCDGDPDCEDGSDESPEQCH---MRTCRIHEISCGAHSTQCIPV--SWRCDGEN 138
                 +KC     C+ G   +P   +   +  C+   I    H   CI    S+RCD   
Sbjct: 634  NEDGSFKCI----CKPGFVLAPNGRYCTDVDECQTPGICMNGH---CINSEGSFRCDCPP 686

Query: 139  DCDSGEDEENCGNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHE- 197
                G D   C +        TC  G    +  VC      +    E  CA P  G  E 
Sbjct: 687  GLAVGMDGRVCVDTHMRS---TCYGG---IKKGVCVRPFPGAVTKSECCCANPDYGFGEP 740

Query: 198  -FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGEC--IHK 254
               C   +      +C      +    + + +C   P I          C +G C  +  
Sbjct: 741  CQPCPAKNSAEFHGLCSSGVGITVDGRD-INECALDPDI----------CANGICENLRG 789

Query: 255  KWRCDGDPDCKDGSDEVNCPS-RTCRPDQFECEDGSCIH--GSRQCNGIRDCVDGSDEVN 311
             +RC+ +   +  +   NC     C  ++  C++G C +  GS  C      V  ++   
Sbjct: 790  SYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNGLCRNTPGSYSCTCPPGYVFRTETET 849

Query: 312  CKNVNQCLGP-----------GKFKCRSGECIDISKVCNQEQDCRDWSDEPLK-ECHIN- 358
            C+++N+C              G F C   EC   SK+ +    C D     LK  C +N 
Sbjct: 850  CEDINECESNPCVNGACRNNLGSFNC---ECSPGSKLSSTGLICID----SLKGTCWLNI 902

Query: 359  ---ECLVNNGGC---SHICKDL--VIGYECD-------CAAGFELIDRKTCGDIDECQN- 402
                C VN  G    S  C  L    G  C+       C  G   I   TC D++EC+  
Sbjct: 903  QDSRCEVNINGATLKSECCATLGAAWGSPCERCELDTACPRGLARIKGVTCEDVNECEVF 962

Query: 403  PGICSQ-ICINLKGGYKCECSRGYQMDLATGVCKAVGKE 440
            PG+C    C+N KG + CEC  G  +D    VC  +  E
Sbjct: 963  PGVCPNGRCVNSKGSFHCECPEGLTLDGTGRVCLDIRME 1001



 Score = 80.9 bits (198), Expect = 5e-15
 Identities = 118/470 (25%), Positives = 181/470 (38%), Gaps = 97/470 (20%)

Query: 34   EPSQFQCTNGRCITLLWKCDGDEDCV-----DGSDEKNCVKKTCAESDF--VCNNGQCVP 86
            E  +  C NG C   +    G  +C+     + +   +C+      S F  VC NG+C  
Sbjct: 1937 ECERHPCGNGTCKNTV----GSYNCLCYPGFELTHNNDCLDIDECSSFFGQVCRNGRCFN 1992

Query: 87   S--RWKCDGDPDCEDGSDESPE--QC-HMRTCRIHEISCGAHSTQCIPVSWRCDGENDCD 141
                +KC     C +G + +P+   C     C     SC   + Q +  S+RC     C 
Sbjct: 1993 EIGSFKCL----CNEGYELTPDGKNCIDTNECVALPGSCSPGTCQNLEGSFRCI----CP 2044

Query: 142  SGED--EENCGNIT-CSPDEFTCSSGRCISR--NFVC----------NG-------QDDC 179
             G +   ENC +I  C  D   C  G C +    F C          NG       Q  C
Sbjct: 2045 PGYEVKSENCIDINECDEDPNICLFGSCTNTPGGFQCLCPPGFVLSDNGRRCFDTRQSFC 2104

Query: 180  SDGSDELDCAPPTC-GAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQ--C----GRQ 232
                +   C+ P      + +C  S      W   D  +   + DE   Q  C    G  
Sbjct: 2105 FTNFENGKCSVPKAFNTTKAKCCCSKMPGEGW--GDPCELCPKDDEVAFQDLCPYGHGTV 2162

Query: 233  PVIH------TKCPASEIQCGSGECIHK--KWRCDGDPDCKDGSDEVNCPSRTCRPDQFE 284
            P +H       +C  S   C +G+CI+    +RC+           V C           
Sbjct: 2163 PSLHDTREDVNECLESPGICSNGQCINTDGSFRCECPMGYNLDYTGVRCVDTDECSIGNP 2222

Query: 285  CEDGSCIH--GSRQCNGIRDCVDGSDE---VNCKNVNQCLGPG---KFKCR----SGECI 332
            C +G+C +  GS +CN    C +G +    +NC+++N+C        F+C     S EC 
Sbjct: 2223 CGNGTCTNVIGSFECN----CNEGFEPGPMMNCEDINECAQNPLLCAFRCMNTFGSYECT 2278

Query: 333  -DISKVCNQEQD-CRDWSDEPLKECHINECLVNNGGCSH---ICKDLVIGYECDCAAGF- 386
              I     ++Q  C+D          ++EC      C     +CK+L+  + C C  G  
Sbjct: 2279 CPIGYALREDQKMCKD----------LDECAEGLHDCESRGMMCKNLIGTFMCICPPGMA 2328

Query: 387  ELIDRKTCGDIDECQN-PGICSQ-ICINLKGGYKCECSRGYQMDLATGVC 434
               D + C D +EC+  PGIC    C+N+ G Y+CEC+ G+Q   +   C
Sbjct: 2329 RRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTEC 2378



 Score = 78.2 bits (191), Expect = 3e-14
 Identities = 97/420 (23%), Positives = 162/420 (38%), Gaps = 84/420 (20%)

Query: 72  CAESDFVCNNGQCVP--SRWKC--------DGDPDCEDGSDESPEQCHMRTCRIHEISCG 121
           C     +C NG+C+P  S ++C        D + DC D      ++C    C        
Sbjct: 498 CKHHANLCLNGRCIPTVSSYRCECNMGYKQDANGDCID-----VDECTSNPCT------- 545

Query: 122 AHSTQCI--PVSWRCDGENDCDSGEDEENCGNIT-CSPDEFTCSSGRCISRNFVCNGQDD 178
             +  C+  P S+ C           ++ C +I  C  +   C +GRC++ +    G   
Sbjct: 546 --NGDCVNTPGSYYCKCHAGFQRTPTKQACIDIDECIQNGVLCKNGRCVNTD----GSFQ 599

Query: 179 C-SDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDA-DCSDQSDESLEQCGRQPVIH 236
           C  +   EL      C  H+   +T+ C+    + +D +  C  +    L   GR     
Sbjct: 600 CICNAGFELTTDGKNCVDHDECTTTNMCLNGMCINEDGSFKCICKPGFVLAPNGRYCTDV 659

Query: 237 TKCPASEIQCGSGECIHKK--WRCDGDPDCKDGSDEVNCPSRTCRPDQFE-CEDGSCIH- 292
            +C    I C +G CI+ +  +RCD  P    G D   C     R   +   + G C+  
Sbjct: 660 DECQTPGI-CMNGHCINSEGSFRCDCPPGLAVGMDGRVCVDTHMRSTCYGGIKKGVCVRP 718

Query: 293 -----------------------------GSRQCNGIRDCVDGSD-EVNCKNVNQC-LGP 321
                                         S + +G+  C  G    V+ +++N+C L P
Sbjct: 719 FPGAVTKSECCCANPDYGFGEPCQPCPAKNSAEFHGL--CSSGVGITVDGRDINECALDP 776

Query: 322 GKFKCRSGECIDI--SKVCN----QEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLV 375
               C +G C ++  S  CN     E D    +   + EC +N  L +NG    +C++  
Sbjct: 777 DI--CANGICENLRGSYRCNCNSGYEPDASGRNCIDIDECLVNRLLCDNG----LCRNTP 830

Query: 376 IGYECDCAAGFEL-IDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVC 434
             Y C C  G+    + +TC DI+EC++    +  C N  G + CECS G ++     +C
Sbjct: 831 GSYSCTCPPGYVFRTETETCEDINECESNPCVNGACRNNLGSFNCECSPGSKLSSTGLIC 890



 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 57/202 (28%), Positives = 80/202 (39%), Gaps = 33/202 (16%)

Query: 246  CGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQF-ECED-GSCIHGSRQCNGIRDC 303
            C +G CI++            GS    CP+     D    CED   C +G   C    DC
Sbjct: 1819 CANGVCINQI-----------GSFRCECPTGFSYNDLLLVCEDIDECSNGDNLCQRNADC 1867

Query: 304  VDGSDEVNCK-NVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKECH------ 356
            ++      C+      L P        EC++I  VC+    C D        CH      
Sbjct: 1868 INSPGSYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGL-CVDLQGSYQCICHNGFKAS 1926

Query: 357  --------INECLVNNGGCSHICKDLVIGYECDCAAGFELIDRKTCGDIDECQN--PGIC 406
                    ++EC  +  G +  CK+ V  Y C C  GFEL     C DIDEC +    +C
Sbjct: 1927 QDQTMCMDVDECERHPCG-NGTCKNTVGSYNCLCYPGFELTHNNDCLDIDECSSFFGQVC 1985

Query: 407  -SQICINLKGGYKCECSRGYQM 427
             +  C N  G +KC C+ GY++
Sbjct: 1986 RNGRCFNEIGSFKCLCNEGYEL 2007



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 106/456 (23%), Positives = 162/456 (35%), Gaps = 109/456 (23%)

Query: 20   RESGATGTGRKAKCEPSQFQCTNGRCITLL--WKCDGDEDCVDGSDEKNCV--------- 68
            R     G   + +C      C NGRC+ ++  ++C+ +E     S    C+         
Sbjct: 2329 RRPDGEGCVDENECRTKPGICENGRCVNIIGSYRCECNEGFQSSSSGTECLDNRQGLCFA 2388

Query: 69   -------------KKTCAESDFVCNNG-----QC--VPSRWKCDGDPDCEDGSDESPEQC 108
                         +    +S+  C+ G     QC   P          C  G   + +  
Sbjct: 2389 EVLQTICQMASSSRNLVTKSECCCDGGRGWGHQCELCPLPGTAQYKKICPHGPGYTTDGR 2448

Query: 109  HMRTCRIHEISCGAHSTQCIPV--SWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRC 166
             +  C++    C   + QCI    S+RC     C  G   +  G      DE + S   C
Sbjct: 2449 DIDECKVMPNLCT--NGQCINTMGSFRCF----CKVGYTTDISGTSCIDLDECSQSPKPC 2502

Query: 167  ISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDAD-CSDQSDES 225
               N++C      ++GS              +QCS     P  +V  +D   C D  +  
Sbjct: 2503 ---NYICKN----TEGS--------------YQCSC----PRGYVLQEDGKTCKDLDECQ 2537

Query: 226  LEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSR-TCR--PDQ 282
             +Q   Q +          +C  G   H    C  + +C  GS    C ++  C+  P  
Sbjct: 2538 TKQHNCQFLCVNTLGGFTCKCPPGFTQHHT-ACIDNNEC--GSQPSLCGAKGICQNTPGS 2594

Query: 283  FECEDGSCIHG-SRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDI--SKVCN 339
            F CE   C  G S    G+          NC++V++C   G  +C+ G C +I     C 
Sbjct: 2595 FSCE---CQRGFSLDATGL----------NCEDVDEC--DGNHRCQHG-CQNILGGYRCG 2638

Query: 340  ------QEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELID-RK 392
                  Q        DE       NEC   N   S  C + +  Y+C C +GF       
Sbjct: 2639 CPQGYIQHYQWNQCVDE-------NECSNPNACGSASCYNTLGSYKCACPSGFSFDQFSS 2691

Query: 393  TCGDIDEC---QNPGICSQICINLKGGYKCECSRGY 425
             C D++EC   +NP  C+  C N +GGY C C  GY
Sbjct: 2692 ACHDVNECSSSKNP--CNYGCSNTEGGYLCGCPPGY 2725



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 87/334 (26%), Positives = 117/334 (35%), Gaps = 75/334 (22%)

Query: 120 CGAH-STQCIPVSWRCDGENDCDSGEDEENCGNITCS-PDEFTCSSGRCISRNFVCNGQD 177
           CG+   + C P      G N C       +CG+  CS P+  TCSSG+  S         
Sbjct: 89  CGSRFHSYCCPGWKTLPGGNQCIVPICRNSCGDGFCSRPNMCTCSSGQISS--------- 139

Query: 178 DCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHT 237
                         TCG+   Q  +  C+      DD   C  Q       CG QPV   
Sbjct: 140 --------------TCGSKSIQQCSVRCMNGGTCADDHCQC--QKGYIGTYCG-QPVCEN 182

Query: 238 KCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIH--GSR 295
            C         G CI    RC     C  G     C        + +   G C     ++
Sbjct: 183 GCQ------NGGRCIGPN-RCA----CVYGFTGPQC--------ERDYRTGPCFTQVNNQ 223

Query: 296 QCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKE- 354
            C G    +  +  + C  + +  G     C +           Q Q CR      ++  
Sbjct: 224 MCQGQLTGIVCTKTLCCATIGRAWGHPCEMCPA-----------QPQPCRRGFIPNIRTG 272

Query: 355 -CH-INECLVNNGGCSH-ICKDLVIGYECDCAAGFELIDR-KTCGDIDECQN-PGICSQ- 408
            C  ++EC    G C    C + V  +EC C AG +  +  + C DIDEC   PGIC   
Sbjct: 273 ACQDVDECQAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDIDECSIIPGICETG 332

Query: 409 ICINLKGGYKCECSRGYQ--------MDLATGVC 434
            C N  G Y C C RGY         +D  TG+C
Sbjct: 333 ECSNTVGSYFCVCPRGYVTSTDGSRCIDQRTGMC 366



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 108/486 (22%), Positives = 170/486 (34%), Gaps = 96/486 (19%)

Query: 21   ESGATGTGRKAKCEP---SQFQ--CTNGRCITL--LWKCDGDEDCVDGSDEKNCVKKTCA 73
            E G T       C+      FQ  C  G C  L  ++ C  D+         NC      
Sbjct: 1477 EMGFTPASDSRSCQDIDECSFQNICVFGTCNNLPGMFHCICDDGYELDRTGGNCTDIDEC 1536

Query: 74   ESDFVCNNGQCV--PSRWKCDGDPDCEDGS------DESPEQCHMR---------TCRIH 116
                 C NG CV  P R++C+  PD +         D     C+++         +C   
Sbjct: 1537 ADPINCVNGLCVNTPGRYECNCPPDFQLNPTGVGCVDNRVGNCYLKFGPRGDGSLSCNT- 1595

Query: 117  EISCGAHSTQC---IPVSWR--CDGENDCDSGEDEENC-GNITCSPDEFT---------- 160
            EI  G   + C   +  +W   C+     +S E    C G     P+  T          
Sbjct: 1596 EIGVGVSRSSCCCSLGKAWGNPCETCPPVNSTEYYTLCPGGEGFRPNPITIILEDIDECQ 1655

Query: 161  -----CSSGRCISRNFVCNGQDDCSDG---------SDELD--------CAPPTCGAHEF 198
                 C  G CI  N   + Q +C  G          +++D        C P TC  +  
Sbjct: 1656 ELPGLCQGGNCI--NTFGSFQCECPQGYYLSEDTRICEDIDECFAHPGVCGPGTC-YNTL 1712

Query: 199  QCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCP--ASEIQCGSGECIHKKW 256
               T  C P     +   +C D       +         + P   ++  C     + K W
Sbjct: 1713 GNYTCICPPEYMQVNGGHNCMDMRKSFCYRSYNGTTCENELPFNVTKRMCCCTYNVGKAW 1772

Query: 257  RCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSC--IHGSRQCNGIRDCVDGSDEVNCKN 314
                +P    G+ +            F+   G    I   ++  GI  C +G     C  
Sbjct: 1773 NKPCEPCPTPGTADFKTICGNIPGFTFDIHTGKAVDIDECKEIPGI--CANGV----C-- 1824

Query: 315  VNQCLGPGKFKCRSGECI-DISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKD 373
            +NQ +G  + +C +G    D+  VC    +C +  +     C  N   +N+ G       
Sbjct: 1825 INQ-IGSFRCECPTGFSYNDLLLVCEDIDECSNGDNL----CQRNADCINSPG------- 1872

Query: 374  LVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQ-ICINLKGGYKCECSRGYQMDLAT 431
                Y C+CAAGF+L     C D +EC + P +CS  +C++L+G Y+C C  G++     
Sbjct: 1873 ---SYRCECAAGFKLSPNGACVDRNECLEIPNVCSHGLCVDLQGSYQCICHNGFKASQDQ 1929

Query: 432  GVCKAV 437
             +C  V
Sbjct: 1930 TMCMDV 1935



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 59/219 (26%), Positives = 82/219 (37%), Gaps = 33/219 (15%)

Query: 240 PASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDG-SCIHGSRQCN 298
           P     CG G C      C     C  G     C S++ +     C +G +C     QC 
Sbjct: 113 PICRNSCGDGFCSRPNM-CT----CSSGQISSTCGSKSIQQCSVRCMNGGTCADDHCQCQ 167

Query: 299 -GIRDCVDGSD--EVNCKNVNQCLGPGKFKC-------------RSGECIDISKVCNQEQ 342
            G      G    E  C+N  +C+GP +  C             R+G C   ++V NQ  
Sbjct: 168 KGYIGTYCGQPVCENGCQNGGRCIGPNRCACVYGFTGPQCERDYRTGPCF--TQVNNQM- 224

Query: 343 DCRDWSDEPLKECHINECLVNNGGC-SHICKDLVIGYECDCAAGF-ELIDRKTCGDIDEC 400
            C+      +  C    C    G    H C ++       C  GF   I    C D+DEC
Sbjct: 225 -CQGQLTGIV--CTKTLCCATIGRAWGHPC-EMCPAQPQPCRRGFIPNIRTGACQDVDEC 280

Query: 401 QN-PGICSQ-ICINLKGGYKCECSRGYQMDLATGVCKAV 437
           Q  PGIC    CIN  G ++C C  G++    T  C+ +
Sbjct: 281 QAIPGICQGGNCINTVGSFECRCPAGHKQSETTQKCEDI 319



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 13/39 (33%), Positives = 22/39 (56%), Gaps = 6/39 (15%)

Query: 715  CEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
            C Y+C       +    Y CSCP GY ++E+G+ C+ ++
Sbjct: 2502 CNYIC------KNTEGSYQCSCPRGYVLQEDGKTCKDLD 2534



 Score = 33.1 bits (74), Expect = 1.1
 Identities = 15/42 (35%), Positives = 20/42 (47%), Gaps = 6/42 (14%)

Query: 712  NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
            NGGC+  C       +    Y CSC  GY +  +GR C  I+
Sbjct: 1250 NGGCDTQC------TNSEGSYECSCSEGYALMPDGRSCADID 1285


>gi|28557796 low density lipoprotein receptor class A domain
           containing 3 [Homo sapiens]
          Length = 345

 Score =  108 bits (271), Expect = 2e-23
 Identities = 50/121 (41%), Positives = 69/121 (57%), Gaps = 15/121 (12%)

Query: 76  DFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCG------AHSTQCIP 129
           +F+C+NG+C+P  W+CDG PDC D SDE       + C   +  CG      A    CI 
Sbjct: 34  NFMCSNGRCIPGAWQCDGLPDCFDKSDE-------KECPKAKSKCGPTFFPCASGIHCII 86

Query: 130 VSWRCDGENDCDSGEDEENC--GNITCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDELD 187
             +RC+G  DC  G DEENC    + CS   + C +G CI ++F+C+GQ++C D SDE  
Sbjct: 87  GRFRCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146

Query: 188 C 188
           C
Sbjct: 147 C 147



 Score =  105 bits (263), Expect = 1e-22
 Identities = 58/149 (38%), Positives = 74/149 (49%), Gaps = 10/149 (6%)

Query: 9   LWLLLALCW----APRESGATGTGRKAKCE-PSQFQCTNGRCITLLWKCDGDEDCVDGSD 63
           +WLL  LC     A       G     +C  P  F C+NGRCI   W+CDG  DC D SD
Sbjct: 1   MWLLGPLCLLLSSAAESQLLPGNNFTNECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSD 60

Query: 64  EKNC--VKKTCAESDFVCNNG-QCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC 120
           EK C   K  C  + F C +G  C+  R++C+G  DC DGSDE     +   C      C
Sbjct: 61  EKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDGSDEENCTANPLLCSTARYHC 120

Query: 121 GAHSTQCIPVSWRCDGENDCDSGEDEENC 149
              +  CI  S+ CDG+N+C    DEE+C
Sbjct: 121 --KNGLCIDKSFICDGQNNCQDNSDEESC 147



 Score =  103 bits (257), Expect = 7e-22
 Identities = 49/108 (45%), Positives = 61/108 (56%), Gaps = 3/108 (2%)

Query: 246 CGSGECIHKKWRCDGDPDCKDGSDEVNCPSRT--CRPDQFECEDG-SCIHGSRQCNGIRD 302
           C +G CI   W+CDG PDC D SDE  CP     C P  F C  G  CI G  +CNG  D
Sbjct: 37  CSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFED 96

Query: 303 CVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
           C DGSDE NC          ++ C++G CID S +C+ + +C+D SDE
Sbjct: 97  CPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDE 144



 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 50/120 (41%), Positives = 69/120 (57%), Gaps = 8/120 (6%)

Query: 198 FQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSG-ECIHKKW 256
           F CS   CIP +W CD   DC D+SDE  ++C   P   +KC  +   C SG  CI  ++
Sbjct: 35  FMCSNGRCIPGAWQCDGLPDCFDKSDE--KEC---PKAKSKCGPTFFPCASGIHCIIGRF 89

Query: 257 RCDGDPDCKDGSDEVNCPSRT--CRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKN 314
           RC+G  DC DGSDE NC +    C   ++ C++G CI  S  C+G  +C D SDE +C++
Sbjct: 90  RCNGFEDCPDGSDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCES 149



 Score = 96.7 bits (239), Expect = 8e-20
 Identities = 46/113 (40%), Positives = 60/113 (53%), Gaps = 5/113 (4%)

Query: 126 QCIPVSWRCDGENDCDSGEDEENC--GNITCSPDEFTCSSG-RCISRNFVCNGQDDCSDG 182
           +CIP +W+CDG  DC    DE+ C      C P  F C+SG  CI   F CNG +DC DG
Sbjct: 41  RCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRCNGFEDCPDG 100

Query: 183 SDELDCA--PPTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCGRQP 233
           SDE +C   P  C    + C    CI  S++CD   +C D SDE   +  ++P
Sbjct: 101 SDEENCTANPLLCSTARYHCKNGLCIDKSFICDGQNNCQDNSDEESCESSQEP 153



 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 50/123 (40%), Positives = 66/123 (53%), Gaps = 8/123 (6%)

Query: 156 PDEFTCSSGRCISRNFVCNGQDDCSDGSDELDC--APPTCGAHEFQCSTS-SCIPISWVC 212
           P  F CS+GRCI   + C+G  DC D SDE +C  A   CG   F C++   CI   + C
Sbjct: 32  PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91

Query: 213 DDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVN 272
           +   DC D SDE  E C   P++   C  +   C +G CI K + CDG  +C+D SDE +
Sbjct: 92  NGFEDCPDGSDE--ENCTANPLL---CSTARYHCKNGLCIDKSFICDGQNNCQDNSDEES 146

Query: 273 CPS 275
           C S
Sbjct: 147 CES 149



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 47/133 (35%), Positives = 61/133 (45%), Gaps = 18/133 (13%)

Query: 280 PDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG-ECIDISKVC 338
           P  F C +G CI G+ QC+G+ DC D SDE  C       GP  F C SG  CI     C
Sbjct: 32  PGNFMCSNGRCIPGAWQCDGLPDCFDKSDEKECPKAKSKCGPTFFPCASGIHCIIGRFRC 91

Query: 339 NQEQDCRDWSDEPLKECHINECLVN-------NGGCSHICKDLVIGYECDCAAGFELIDR 391
           N  +DC D SDE  + C  N  L +       NG C  I K  +   + +C    +  D 
Sbjct: 92  NGFEDCPDGSDE--ENCTANPLLCSTARYHCKNGLC--IDKSFICDGQNNCQ---DNSDE 144

Query: 392 KTCGDIDECQNPG 404
           ++C   +  Q PG
Sbjct: 145 ESC---ESSQEPG 154



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 34/104 (32%), Positives = 48/104 (46%), Gaps = 10/104 (9%)

Query: 316 NQCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC--HINECLVNNGGCSHICKD 373
           N+C  PG F C +G CI  +  C+   DC D SDE  KEC    ++C      C+     
Sbjct: 27  NECNIPGNFMCSNGRCIPGAWQCDGLPDCFDKSDE--KECPKAKSKCGPTFFPCASGIHC 84

Query: 374 LVIGYECDCAAGFELIDRKTCGDIDEC-QNPGICSQICINLKGG 416
           ++  + C+   GFE  D     D + C  NP +CS    + K G
Sbjct: 85  IIGRFRCN---GFE--DCPDGSDEENCTANPLLCSTARYHCKNG 123


>gi|7706111 8D6 antigen [Homo sapiens]
          Length = 282

 Score =  107 bits (266), Expect = 6e-23
 Identities = 55/143 (38%), Positives = 70/143 (48%), Gaps = 12/143 (8%)

Query: 19  PRESGATGTGRKAKCEPSQFQC-TNGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDF 77
           P  + A G      C P++FQC T+G C+ L W+CD D DC DGSDE+ C  + C +   
Sbjct: 41  PTSAQAAGPS-SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCTQ--- 96

Query: 78  VCNNGQCVPS---RWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRC 134
               GQC P       C G  DC  G+D+    C    C   E+ C   S  CIP++WRC
Sbjct: 97  ---KGQCPPPPGLPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRC-TLSDDCIPLTWRC 152

Query: 135 DGENDCDSGEDEENCGNITCSPD 157
           DG  DC    DE  CG     P+
Sbjct: 153 DGHPDCPDSSDELGCGTNEILPE 175



 Score = 92.8 bits (229), Expect = 1e-18
 Identities = 50/131 (38%), Positives = 68/131 (51%), Gaps = 10/131 (7%)

Query: 153 TCSPDEFTC-SSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQCSTSSCIPISWV 211
           +C P +F C +SG C+   + C+   DCSDGSDE +C    C   + QC     +P    
Sbjct: 53  SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPC-TQKGQCPPPPGLPCP-- 109

Query: 212 CDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQCG-SGECIHKKWRCDGDPDCKDGSDE 270
           C   +DCS  +D+ L  C R       C A E++C  S +CI   WRCDG PDC D SDE
Sbjct: 110 CTGVSDCSGGTDKKLRNCSR-----LACLAGELRCTLSDDCIPLTWRCDGHPDCPDSSDE 164

Query: 271 VNCPSRTCRPD 281
           + C +    P+
Sbjct: 165 LGCGTNEILPE 175



 Score = 77.0 bits (188), Expect = 7e-14
 Identities = 49/137 (35%), Positives = 66/137 (48%), Gaps = 19/137 (13%)

Query: 192 TCGAHEFQCSTSS-CIPISWVCDDDADCSDQSDESLEQCGRQPVIHT-KCPASE-IQCGS 248
           +C   +FQC TS  C+P++W CD D DCSD SDE  E+C  +P     +CP    + C  
Sbjct: 53  SCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDE--EECRIEPCTQKGQCPPPPGLPCP- 109

Query: 249 GECIHKKWRCDGDPDCKDGSDEV--NCPSRTCRPDQFECE-DGSCIHGSRQCNGIRDCVD 305
                    C G  DC  G+D+   NC    C   +  C     CI  + +C+G  DC D
Sbjct: 110 ---------CTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCDGHPDCPD 160

Query: 306 GSDEVNCKNVNQCLGPG 322
            SDE+ C   N+ L  G
Sbjct: 161 SSDELGC-GTNEILPEG 176



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 49/130 (37%), Positives = 63/130 (48%), Gaps = 17/130 (13%)

Query: 239 CPASEIQCG-SGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECEDGSCIHGSR-- 295
           CP ++ QC  SG C+   WRCD D DC DGSDE  C    C       + G C       
Sbjct: 54  CPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECRIEPCT------QKGQCPPPPGLP 107

Query: 296 -QCNGIRDCVDGSDEV--NCKNVNQCLGPGKFKCR-SGECIDISKVCNQEQDCRDWSDEP 351
             C G+ DC  G+D+   NC  +  CL  G+ +C  S +CI ++  C+   DC D SDE 
Sbjct: 108 CPCTGVSDCSGGTDKKLRNCSRL-ACLA-GELRCTLSDDCIPLTWRCDGHPDCPDSSDE- 164

Query: 352 LKECHINECL 361
              C  NE L
Sbjct: 165 -LGCGTNEIL 173



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 30/108 (27%), Positives = 48/108 (44%), Gaps = 6/108 (5%)

Query: 275 SRTCRPDQFECE-DGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECID 333
           S +C P +F+C   G C+  + +C+   DC DGSDE  C+ +  C   G+     G    
Sbjct: 51  SGSCPPTKFQCRTSGLCVPLTWRCDRDLDCSDGSDEEECR-IEPCTQKGQCPPPPG---- 105

Query: 334 ISKVCNQEQDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECD 381
           +   C    DC   +D+ L+ C    CL     C+     + + + CD
Sbjct: 106 LPCPCTGVSDCSGGTDKKLRNCSRLACLAGELRCTLSDDCIPLTWRCD 153


>gi|46249414 latent transforming growth factor beta binding protein 1
            isoform LTBP-1L [Homo sapiens]
          Length = 1722

 Score =  105 bits (261), Expect = 2e-22
 Identities = 96/375 (25%), Positives = 151/375 (40%), Gaps = 56/375 (14%)

Query: 113  CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNIT-CSPDEFTCSSGRCISR-- 169
            C ++   CGA     +PV + C         E +  C +I  C+  +  CS GRC +   
Sbjct: 878  CTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEG 937

Query: 170  NFVC------NGQDDCSDGSDELDCAPP----------TCGAHEFQ-CSTSSCIPISWVC 212
            +F+C         ++ ++  D  +C  P          T GA   + C +   +     C
Sbjct: 938  SFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRC 997

Query: 213  DDDADCSDQSDESLEQCGRQPVIHTKCPASEI------QC-GSGECIHKKWRCDGDPDCK 265
            +D  +C + S    EQC   P  +   P +E       QC    EC+      +GD    
Sbjct: 998  EDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNL 1057

Query: 266  DGSDEVNCPSRTCR-PDQFECED-GSCIHGSRQCNGIRDCVDGSDEVNC----------- 312
            +GS   +C     R PD   C D   C  G+   NG     +GS    C           
Sbjct: 1058 EGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKD 1117

Query: 313  --KNVNQCLGPGKFKCRSGECIDISK----VCNQEQDCRDWSDEPLKECH-INECLVNNG 365
              +++++C    +  C  G+C +       VC+Q        D     C  INECL +  
Sbjct: 1118 QCEDIDEC--QHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDH----CEDINECLEDKS 1171

Query: 366  GCSH-ICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQ--ICINLKGGYKCECS 422
             C    C +    Y+C C  GF+L D KTC DI+EC++PG+C     C+N +G + C C 
Sbjct: 1172 VCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQ 1231

Query: 423  RGYQMDLATGVCKAV 437
            +G+ +      C+ +
Sbjct: 1232 QGFSISADGRTCEDI 1246



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 118/460 (25%), Positives = 181/460 (39%), Gaps = 103/460 (22%)

Query: 32   KCEPSQFQCTNGRCI----TLLWKC-------DGDEDCVDGSD--------EKNCVKKTC 72
            +C   Q  C+ GRC     + L  C       +   +C+D  +        E +CV    
Sbjct: 919  ECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVG 978

Query: 73   AESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC----GAHSTQCI 128
            A     C++G  +  R +C+   +C + S    EQC         + C       + QC+
Sbjct: 979  AFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCL 1038

Query: 129  PVSWRCDGENDCDSGEDEENCGNITCS--------PDEFTCSS-GRCISRNFVCNGQDDC 179
             V   C   N C +G+     G+  CS        PD   C     C   N   NGQ  C
Sbjct: 1039 DVD-ECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQ--C 1095

Query: 180  SDGSDELDCAPPTCG-AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQC-GRQPVIHT 237
             +      C   TCG  ++   +   C                  E +++C  R    H 
Sbjct: 1096 KNTEGSFRC---TCGQGYQLSAAKDQC------------------EDIDECQHRHLCAHG 1134

Query: 238  KCPASEIQCGSGECI-HKKWRCDGDPD-CKDGSDEVNCPSRTCRPDQFECEDGSCIH--G 293
            +C  +E   GS +C+  + +R  G  D C+D ++        C  D+  C+ G CI+  G
Sbjct: 1135 QCRNTE---GSFQCVCDQGYRASGLGDHCEDINE--------CLEDKSVCQRGDCINTAG 1183

Query: 294  SRQCNGIRDCVDG---SDEVNCKNVNQCLGPGKFKCRSGECIDISK----VCNQ----EQ 342
            S  C     C DG    D   C+++N+C  PG      GEC++       VC Q      
Sbjct: 1184 SYDCT----CPDGFQLDDNKTCQDINECEHPG-LCGPQGECLNTEGSFHCVCQQGFSISA 1238

Query: 343  DCRDWSDEPLKECHINECLVNNGGC-SH-ICKDLVIGYECDCAAGFEL-IDRKTCGDIDE 399
            D R   D       I+EC VNN  C SH  C +    + C C  GF+   D + C D++E
Sbjct: 1239 DGRTCED-------IDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNE 1290

Query: 400  CQ-NPGICSQ-ICINLKGGYKCECS-RGYQMDLATGVCKA 436
            C+   G+C +  C N++G + C C+    +    TG C++
Sbjct: 1291 CELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1330



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 104/469 (22%), Positives = 157/469 (33%), Gaps = 84/469 (17%)

Query: 40   CTNGRCITL--LWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS----RWKCDG 93
            C NG C  L   + C   +      D K+C      +   +C NGQC  +    R  C  
Sbjct: 1049 CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQ 1108

Query: 94   DPDCEDGSD--ESPEQC-HMRTCRIHEISCGAHSTQCI-PVSWRCDGEND---------- 139
                    D  E  ++C H   C   +      S QC+    +R  G  D          
Sbjct: 1109 GYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLE 1168

Query: 140  ----CDSGEDEENCGNITCS-PDEF------TCSSGRCISRNFVCNGQDDCSDGSDELDC 188
                C  G+     G+  C+ PD F      TC          +C  Q +C +      C
Sbjct: 1169 DKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHC 1228

Query: 189  APP---TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE---------SLEQCGRQPVIH 236
                  +  A    C        + VCD    C + +              Q G+  V  
Sbjct: 1229 VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDV 1288

Query: 237  TKCPASEIQCGSGEC--IHKKWRCDGDPDCKDGSDEVN-----CPSRTCRP-----DQFE 284
             +C      CG   C  +   + C     C D + E +     C SRT        DQ +
Sbjct: 1289 NECELLSGVCGEAFCENVEGSFLCV----CADENQEYSPMTGQCRSRTSTDLDVDVDQPK 1344

Query: 285  CEDGSC---IHGSRQCNGIRD---------CVDGSDEVNCKNVNQC--LGPGKFK--CRS 328
             E   C   ++ +  C+ +           C  G+   +   +  C  LG  +F   C  
Sbjct: 1345 EEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPK 1404

Query: 329  GECIDISKVCNQEQDCRDWSDEPLKECHI-NECLVNNGGCSHICKDLVIGYECDCAAGFE 387
            G+    +   + E    ++ D    EC +  + +  NG     C +   GYEC C  G  
Sbjct: 1405 GKGFVPAGESSSEAGGENYKDAD--ECLLFGQEICKNG----FCLNTRPGYECYCKQGTY 1458

Query: 388  LIDRKT-CGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
                K  C D+DECQ+P  C    C+N +G Y C C+    +D +   C
Sbjct: 1459 YDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRC 1507



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/103 (33%), Positives = 46/103 (44%), Gaps = 9/103 (8%)

Query: 332  IDISKVCNQEQD---CRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFEL 388
            +D S+    E D    +D      +E    EC + NG  +  C  +  GY CDC  G+ L
Sbjct: 1595 VDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHL 1654

Query: 389  IDRK-TCGDIDEC----QNPGICSQI-CINLKGGYKCECSRGY 425
               K TC D++EC        +C    CIN  G YKC C  GY
Sbjct: 1655 DTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGY 1697



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 1/55 (1%)

Query: 381 DCAAGFELIDRKTCGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
           +C  G++ ++   C DI+ECQ  G+C +  C+N  G Y+C C  G+  D     C
Sbjct: 611 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 665



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 5/54 (9%)

Query: 386  FELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK 439
            FE +  + CG ++ C+N       C+ ++ GY C+C  GY +D A   C  V +
Sbjct: 1618 FEELQAEECGILNGCENGR-----CVRVQEGYTCDCFDGYHLDTAKMTCVDVNE 1666



 Score = 30.8 bits (68), Expect = 5.5
 Identities = 28/102 (27%), Positives = 37/102 (36%), Gaps = 26/102 (25%)

Query: 230 GRQPVIHTKCPASEIQCGSGEC--IHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECED 287
           GRQ V+ +K P  E Q G G    +H+K +  G   C                       
Sbjct: 135 GRQ-VVRSKVP-QETQSGGGSRLQVHQKQQLQGVNVC----------------------G 170

Query: 288 GSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSG 329
           G C HG  +  G + C   S    C+N   CL P    C+ G
Sbjct: 171 GRCCHGWSKAPGSQRCTKPSCVPPCQNGGMCLRPQLCVCKPG 212


>gi|46249412 latent transforming growth factor beta binding protein
           1 isoform LTBP-1S [Homo sapiens]
          Length = 1396

 Score =  105 bits (261), Expect = 2e-22
 Identities = 96/375 (25%), Positives = 151/375 (40%), Gaps = 56/375 (14%)

Query: 113 CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNIT-CSPDEFTCSSGRCISR-- 169
           C ++   CGA     +PV + C         E +  C +I  C+  +  CS GRC +   
Sbjct: 552 CTVNPDICGAGHCINLPVRYTCICYEGYRFSEQQRKCVDIDECTQVQHLCSQGRCENTEG 611

Query: 170 NFVC------NGQDDCSDGSDELDCAPP----------TCGAHEFQ-CSTSSCIPISWVC 212
           +F+C         ++ ++  D  +C  P          T GA   + C +   +     C
Sbjct: 612 SFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVGAFRCEYCDSGYRMTQRGRC 671

Query: 213 DDDADCSDQSDESLEQCGRQPVIHTKCPASEI------QC-GSGECIHKKWRCDGDPDCK 265
           +D  +C + S    EQC   P  +   P +E       QC    EC+      +GD    
Sbjct: 672 EDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCLDVDECLEPNVCANGDCSNL 731

Query: 266 DGSDEVNCPSRTCR-PDQFECED-GSCIHGSRQCNGIRDCVDGSDEVNC----------- 312
           +GS   +C     R PD   C D   C  G+   NG     +GS    C           
Sbjct: 732 EGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQGYQLSAAKD 791

Query: 313 --KNVNQCLGPGKFKCRSGECIDISK----VCNQEQDCRDWSDEPLKECH-INECLVNNG 365
             +++++C    +  C  G+C +       VC+Q        D     C  INECL +  
Sbjct: 792 QCEDIDEC--QHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDH----CEDINECLEDKS 845

Query: 366 GCSH-ICKDLVIGYECDCAAGFELIDRKTCGDIDECQNPGICSQ--ICINLKGGYKCECS 422
            C    C +    Y+C C  GF+L D KTC DI+EC++PG+C     C+N +G + C C 
Sbjct: 846 VCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHCVCQ 905

Query: 423 RGYQMDLATGVCKAV 437
           +G+ +      C+ +
Sbjct: 906 QGFSISADGRTCEDI 920



 Score = 93.2 bits (230), Expect = 9e-19
 Identities = 118/460 (25%), Positives = 181/460 (39%), Gaps = 103/460 (22%)

Query: 32   KCEPSQFQCTNGRCI----TLLWKC-------DGDEDCVDGSD--------EKNCVKKTC 72
            +C   Q  C+ GRC     + L  C       +   +C+D  +        E +CV    
Sbjct: 593  ECTQVQHLCSQGRCENTEGSFLCICPAGFMASEEGTNCIDVDECLRPDVCGEGHCVNTVG 652

Query: 73   AESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISC----GAHSTQCI 128
            A     C++G  +  R +C+   +C + S    EQC         + C       + QC+
Sbjct: 653  AFRCEYCDSGYRMTQRGRCEDIDECLNPSTCPDEQCVNSPGSYQCVPCTEGFRGWNGQCL 712

Query: 129  PVSWRCDGENDCDSGEDEENCGNITCS--------PDEFTCSS-GRCISRNFVCNGQDDC 179
             V   C   N C +G+     G+  CS        PD   C     C   N   NGQ  C
Sbjct: 713  DVD-ECLEPNVCANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQ--C 769

Query: 180  SDGSDELDCAPPTCG-AHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQC-GRQPVIHT 237
             +      C   TCG  ++   +   C                  E +++C  R    H 
Sbjct: 770  KNTEGSFRC---TCGQGYQLSAAKDQC------------------EDIDECQHRHLCAHG 808

Query: 238  KCPASEIQCGSGECI-HKKWRCDGDPD-CKDGSDEVNCPSRTCRPDQFECEDGSCIH--G 293
            +C  +E   GS +C+  + +R  G  D C+D ++        C  D+  C+ G CI+  G
Sbjct: 809  QCRNTE---GSFQCVCDQGYRASGLGDHCEDINE--------CLEDKSVCQRGDCINTAG 857

Query: 294  SRQCNGIRDCVDG---SDEVNCKNVNQCLGPGKFKCRSGECIDISK----VCNQ----EQ 342
            S  C     C DG    D   C+++N+C  PG      GEC++       VC Q      
Sbjct: 858  SYDCT----CPDGFQLDDNKTCQDINECEHPG-LCGPQGECLNTEGSFHCVCQQGFSISA 912

Query: 343  DCRDWSDEPLKECHINECLVNNGGC-SH-ICKDLVIGYECDCAAGFEL-IDRKTCGDIDE 399
            D R   D       I+EC VNN  C SH  C +    + C C  GF+   D + C D++E
Sbjct: 913  DGRTCED-------IDEC-VNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDVNE 964

Query: 400  CQ-NPGICSQ-ICINLKGGYKCECS-RGYQMDLATGVCKA 436
            C+   G+C +  C N++G + C C+    +    TG C++
Sbjct: 965  CELLSGVCGEAFCENVEGSFLCVCADENQEYSPMTGQCRS 1004



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 104/469 (22%), Positives = 157/469 (33%), Gaps = 84/469 (17%)

Query: 40   CTNGRCITL--LWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPS----RWKCDG 93
            C NG C  L   + C   +      D K+C      +   +C NGQC  +    R  C  
Sbjct: 723  CANGDCSNLEGSYMCSCHKGYTRTPDHKHCRDIDECQQGNLCVNGQCKNTEGSFRCTCGQ 782

Query: 94   DPDCEDGSD--ESPEQC-HMRTCRIHEISCGAHSTQCI-PVSWRCDGEND---------- 139
                    D  E  ++C H   C   +      S QC+    +R  G  D          
Sbjct: 783  GYQLSAAKDQCEDIDECQHRHLCAHGQCRNTEGSFQCVCDQGYRASGLGDHCEDINECLE 842

Query: 140  ----CDSGEDEENCGNITCS-PDEF------TCSSGRCISRNFVCNGQDDCSDGSDELDC 188
                C  G+     G+  C+ PD F      TC          +C  Q +C +      C
Sbjct: 843  DKSVCQRGDCINTAGSYDCTCPDGFQLDDNKTCQDINECEHPGLCGPQGECLNTEGSFHC 902

Query: 189  APP---TCGAHEFQCSTSSCIPISWVCDDDADCSDQSDE---------SLEQCGRQPVIH 236
                  +  A    C        + VCD    C + +              Q G+  V  
Sbjct: 903  VCQQGFSISADGRTCEDIDECVNNTVCDSHGFCDNTAGSFRCLCYQGFQAPQDGQGCVDV 962

Query: 237  TKCPASEIQCGSGEC--IHKKWRCDGDPDCKDGSDEVN-----CPSRTCRP-----DQFE 284
             +C      CG   C  +   + C     C D + E +     C SRT        DQ +
Sbjct: 963  NECELLSGVCGEAFCENVEGSFLCV----CADENQEYSPMTGQCRSRTSTDLDVDVDQPK 1018

Query: 285  CEDGSC---IHGSRQCNGIRD---------CVDGSDEVNCKNVNQC--LGPGKFK--CRS 328
             E   C   ++ +  C+ +           C  G+   +   +  C  LG  +F   C  
Sbjct: 1019 EEKKECYYNLNDASLCDNVLAPNVTKQECCCTSGAGWGDNCEIFPCPVLGTAEFTEMCPK 1078

Query: 329  GECIDISKVCNQEQDCRDWSDEPLKECHI-NECLVNNGGCSHICKDLVIGYECDCAAGFE 387
            G+    +   + E    ++ D    EC +  + +  NG     C +   GYEC C  G  
Sbjct: 1079 GKGFVPAGESSSEAGGENYKDAD--ECLLFGQEICKNG----FCLNTRPGYECYCKQGTY 1132

Query: 388  LIDRKT-CGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
                K  C D+DECQ+P  C    C+N +G Y C C+    +D +   C
Sbjct: 1133 YDPVKLQCFDMDECQDPSSCIDGQCVNTEGSYNCFCTHPMVLDASEKRC 1181



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 35/103 (33%), Positives = 46/103 (44%), Gaps = 9/103 (8%)

Query: 332  IDISKVCNQEQD---CRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFEL 388
            +D S+    E D    +D      +E    EC + NG  +  C  +  GY CDC  G+ L
Sbjct: 1269 VDFSEQYTPEADPYFIQDRFLNSFEELQAEECGILNGCENGRCVRVQEGYTCDCFDGYHL 1328

Query: 389  IDRK-TCGDIDEC----QNPGICSQI-CINLKGGYKCECSRGY 425
               K TC D++EC        +C    CIN  G YKC C  GY
Sbjct: 1329 DTAKMTCVDVNECDELNNRMSLCKNAKCINTDGSYKCLCLPGY 1371



 Score = 47.0 bits (110), Expect = 7e-05
 Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 1/55 (1%)

Query: 381 DCAAGFELIDRKTCGDIDECQNPGIC-SQICINLKGGYKCECSRGYQMDLATGVC 434
           +C  G++ ++   C DI+ECQ  G+C +  C+N  G Y+C C  G+  D     C
Sbjct: 285 ECLPGYKRVNNTFCQDINECQLQGVCPNGECLNTMGSYRCTCKIGFGPDPTFSSC 339



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 17/54 (31%), Positives = 28/54 (51%), Gaps = 5/54 (9%)

Query: 386  FELIDRKTCGDIDECQNPGICSQICINLKGGYKCECSRGYQMDLATGVCKAVGK 439
            FE +  + CG ++ C+N       C+ ++ GY C+C  GY +D A   C  V +
Sbjct: 1292 FEELQAEECGILNGCENGR-----CVRVQEGYTCDCFDGYHLDTAKMTCVDVNE 1340


>gi|120587029 signal peptide, CUB domain, EGF-like 1 [Homo sapiens]
          Length = 988

 Score =  103 bits (257), Expect = 7e-22
 Identities = 117/445 (26%), Positives = 167/445 (37%), Gaps = 113/445 (25%)

Query: 1   MGTSAL-WALWLLLALCWAPRESGATGTGRKAKCEPSQFQCTNGRCITLLWKCDGDEDCV 59
           MG +A+ W L +LLAL    R +G +G                     L    D DE C 
Sbjct: 1   MGAAAVRWHLCVLLALGTRGRLAGGSG---------------------LPGSVDVDE-CS 38

Query: 60  DGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCH-MRTCRIHEI 118
           +G+D+           D +C N    P  +KC     C+ G     +QC  +  C     
Sbjct: 39  EGTDD--------CHIDAICQN---TPKSYKCL----CKPGYKGEGKQCEDIDECENDYY 83

Query: 119 SCGA-HSTQCIPVSWRC----------DGENDCDSGEDEENCGNIT--C--SPDEFTCSS 163
           + G  H    IP ++RC          DG N  D  E ++N G     C  +   + C  
Sbjct: 84  NGGCVHECINIPGNYRCTCFDGFMLAHDGHNCLDVDECQDNNGGCQQICVNAMGSYEC-- 141

Query: 164 GRCISRNFVCNGQDDCSDGSDE-LDCAPPTCGAHEFQCSTSSCIPISWVCDDDADCSDQS 222
            +C S  F+ + Q  C   S+E ++C     G     C  +    ++  C    D +   
Sbjct: 142 -QCHSGFFLSDNQHTCIHRSNEGMNCMNKDHGCAHI-CRETPKGGVACDCRPGFDLAQNQ 199

Query: 223 DESLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSD-EVNCPSRTCRPD 281
            +    C                 G+G C H     D  P C       ++   RTC   
Sbjct: 200 KDCTLTCNY---------------GNGGCQHSCEDTDTGPTCGCHQKYALHSDGRTCIE- 243

Query: 282 QFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVNQCLGPGKFKCRSGECIDISKVCNQE 341
                  +C   +  C+  R C D +  V C             C  G  +         
Sbjct: 244 -------TCAVNNGGCD--RTCKDTATGVRCS------------CPVGFTLQ-----PDG 277

Query: 342 QDCRDWSDEPLKECHINECLVNNGGCSHICKDLVIGYECDCAAGFELI-DRKTCGDIDEC 400
           + C+D          INECLVNNGGC H C++ V  +EC C  G++L+ D +TC DIDEC
Sbjct: 278 KTCKD----------INECLVNNGGCDHFCRNTVGSFECGCRKGYKLLTDERTCQDIDEC 327

Query: 401 QNPGICSQICINLKGGYKCECSRGY 425
                C  ICIN  G ++C C RGY
Sbjct: 328 SFERTCDHICINSPGSFQCLCHRGY 352



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 15/44 (34%), Positives = 24/44 (54%), Gaps = 6/44 (13%)

Query: 710 MENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
           + NGGC+  C       D +    CSCP G+ ++ +G+ C+ IN
Sbjct: 247 VNNGGCDRTC------KDTATGVRCSCPVGFTLQPDGKTCKDIN 284



 Score = 36.2 bits (82), Expect = 0.13
 Identities = 15/44 (34%), Positives = 22/44 (50%), Gaps = 6/44 (13%)

Query: 706 CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
           CE D  NGGC + C+  P        Y C+C  G+ +  +G +C
Sbjct: 78  CENDYYNGGCVHECINIP------GNYRCTCFDGFMLAHDGHNC 115



 Score = 33.5 bits (75), Expect = 0.85
 Identities = 19/60 (31%), Positives = 29/60 (48%), Gaps = 11/60 (18%)

Query: 698 VQPSGKNWCEEDME----NGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDCQRIN 753
           +QP GK  C++  E    NGGC++ C       +    + C C  GY +  + R CQ I+
Sbjct: 273 LQPDGKT-CKDINECLVNNGGCDHFC------RNTVGSFECGCRKGYKLLTDERTCQDID 325



 Score = 32.7 bits (73), Expect = 1.4
 Identities = 15/43 (34%), Positives = 20/43 (46%), Gaps = 6/43 (13%)

Query: 707 EEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
           E  M NG C+  C+      +    Y C CP G  +  NG+DC
Sbjct: 365 ECSMSNGSCDQGCV------NTKGSYECVCPPGRRLHWNGKDC 401



 Score = 31.6 bits (70), Expect = 3.2
 Identities = 14/44 (31%), Positives = 23/44 (52%), Gaps = 8/44 (18%)

Query: 706 CEEDMENGGCEYLCLPAPQINDHSPKYTCSCPSGYNVEENGRDC 749
           C+++  NGGC+ +C+ A         Y C C SG+ + +N   C
Sbjct: 121 CQDN--NGGCQQICVNA------MGSYECQCHSGFFLSDNQHTC 156


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.136    0.450 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,592,814
Number of Sequences: 37866
Number of extensions: 2069264
Number of successful extensions: 9533
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 137
Number of HSP's successfully gapped in prelim test: 263
Number of HSP's that attempted gapping in prelim test: 3905
Number of HSP's gapped (non-prelim): 2434
length of query: 845
length of database: 18,247,518
effective HSP length: 111
effective length of query: 734
effective length of database: 14,044,392
effective search space: 10308583728
effective search space used: 10308583728
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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