Guide to the Human Genome
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Search of human proteins with 63054860

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|63054860 RCC1 domain containing 1 [Homo sapiens]
         (376 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|63054860 RCC1 domain containing 1 [Homo sapiens]                   776   0.0  
gi|63054858 RCC1 domain containing 1 [Homo sapiens]                   776   0.0  
gi|126032348 hect domain and RLD 2 [Homo sapiens]                     115   6e-26
gi|110825982 hect domain and RLD 5 [Homo sapiens]                     114   1e-25
gi|7657152 hect domain and RLD 3 [Homo sapiens]                       105   9e-23
gi|61563742 hect domain and RLD 6 [Homo sapiens]                      101   1e-21
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]            100   3e-21
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]            100   3e-21
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]    97   2e-20
gi|4557445 regulator of chromosome condensation and BTB domain c...    90   4e-18
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]     89   5e-18
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]      89   5e-18
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                      87   3e-17
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                       79   7e-15
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo...    74   2e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    74   2e-13
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ...    72   6e-13
gi|114796644 regulator of chromosome condensation 1 isoform a [H...    70   4e-12
gi|114796646 regulator of chromosome condensation 1 isoform b [H...    69   9e-12
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom...    69   9e-12
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]     69   9e-12
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]     69   9e-12
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]     69   9e-12
gi|6912330 deafness locus associated putative guanine nucleotide...    67   3e-11
gi|40316935 alsin isoform 1 [Homo sapiens]                             66   4e-11
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ...    65   1e-10
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s...    65   1e-10
gi|126116565 MYC binding protein 2 [Homo sapiens]                      65   1e-10
gi|209364523 alsin isoform 2 [Homo sapiens]                            64   2e-10
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ...    62   1e-09

>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score =  776 bits (2003), Expect = 0.0
 Identities = 376/376 (100%), Positives = 376/376 (100%)

Query: 1   MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL 60
           MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL
Sbjct: 1   MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL 60

Query: 61  ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE 120
           ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE
Sbjct: 61  ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE 120

Query: 121 GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF 180
           GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF
Sbjct: 121 GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF 180

Query: 181 SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG 240
           SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG
Sbjct: 181 SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG 240

Query: 241 QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS 300
           QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS
Sbjct: 241 QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS 300

Query: 301 DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360
           DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT
Sbjct: 301 DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360

Query: 361 CGPWNTYVYAVEKGKS 376
           CGPWNTYVYAVEKGKS
Sbjct: 361 CGPWNTYVYAVEKGKS 376


>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score =  776 bits (2003), Expect = 0.0
 Identities = 376/376 (100%), Positives = 376/376 (100%)

Query: 1   MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL 60
           MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL
Sbjct: 1   MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL 60

Query: 61  ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE 120
           ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE
Sbjct: 61  ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE 120

Query: 121 GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF 180
           GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF
Sbjct: 121 GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF 180

Query: 181 SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG 240
           SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG
Sbjct: 181 SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG 240

Query: 241 QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS 300
           QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS
Sbjct: 241 QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS 300

Query: 301 DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360
           DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT
Sbjct: 301 DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360

Query: 361 CGPWNTYVYAVEKGKS 376
           CGPWNTYVYAVEKGKS
Sbjct: 361 CGPWNTYVYAVEKGKS 376


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score =  115 bits (288), Expect = 6e-26
 Identities = 70/213 (32%), Positives = 99/213 (46%), Gaps = 32/213 (15%)

Query: 166  GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCV 225
            G +H L L + G+V+SWG    G+LGHG       PR++E+L+G+ + +VAAGG HS CV
Sbjct: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4106

Query: 226  SETGDIYIWGWNESGQLA--------LPTRNLAEDGETVAREATELNE------------ 265
            +  GD+Y WG    G+L          P    A  G  V   A    +            
Sbjct: 4107 TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTV 4166

Query: 266  ----DGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGEL 321
                DG   K   G  DG   P          +D   G   VK  CGS+ +  +T++G +
Sbjct: 4167 WSWGDGDYGKLGRGGSDGCKVPM--------KIDSLTGLGVVKVECGSQFSVALTKSGAV 4218

Query: 322  YTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL 354
            YTWG G Y +LGH     + RPR+V+    K++
Sbjct: 4219 YTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKV 4251



 Score =  102 bits (255), Expect = 4e-22
 Identities = 108/396 (27%), Positives = 162/396 (40%), Gaps = 50/396 (12%)

Query: 7    GAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSA-SWSYTAF-VTRGGRLELSG 64
            G  +G+G    GQ LG   G +V  P+P  A   +  V       T F VT  G+L  +G
Sbjct: 3952 GTIYGWGHNHRGQ-LGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010

Query: 65   SASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDD 124
               GA GR             L      E++  V+  + A+         +   +EGE  
Sbjct: 4011 Y--GAGGRLGIGGTESVSTPTLL-----ESIQHVFIKKVAVNSGGKHC--LALSSEGEVY 4061

Query: 125  PAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPE----LRARQLELGAEHALLLDAAGQVF 180
              GEA+ G+L            R+P  RP   E    +    +  G  H+  + AAG ++
Sbjct: 4062 SWGEAEDGKLGH--------GNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 4113

Query: 181  SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGW--HSVCVSETGDIYIWGWNE 238
            +WG GR+G+LGH   E +L+P+L+EALQG  + ++A G     ++C+++   ++ WG  +
Sbjct: 4114 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGD 4173

Query: 239  SGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPF-------- 290
             G+L         DG  V  +   L   G      G     A     AV  +        
Sbjct: 4174 YGKLGRG----GSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 4229

Query: 291  ----------PALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSL 340
                      P  +    G   +  + GS H    T  GE+YTWG    GQLG   T ++
Sbjct: 4230 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAI 4289

Query: 341  DRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGKS 376
             RPR V     K  +V  V CG  +T  ++  K  S
Sbjct: 4290 QRPRLVAALQGK--KVNRVACGSAHTLAWSTSKPAS 4323



 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 73/270 (27%), Positives = 117/270 (43%), Gaps = 45/270 (16%)

Query: 120  EGEDDPAGEAQAGRLPL------LPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLL 173
            EG+    GEA  GRL L      +P  R   +  +   + +A       +  G  HA  L
Sbjct: 3010 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVA-------VHSGGRHATAL 3062

Query: 174  DAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYI 233
               G+VFSWG G  G+LGH +     +PRL+EAL+   + ++A G  HS  ++ +G++Y 
Sbjct: 3063 TVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYT 3122

Query: 234  WGWNESGQL---------------------ALPTRNLAEDGETVAREATELN---EDGSQ 269
            WG  E G+L                      +     + D +T+A     L     DG  
Sbjct: 3123 WGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDF 3182

Query: 270  VKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKY 329
             K   G  +G           P  ++   G    +  CG++ +  +T++G ++TWG G Y
Sbjct: 3183 GKLGRGGSEGC--------NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDY 3234

Query: 330  GQLGHEDTTSLDRPRRVEYFVDKQLQVKAV 359
             +LGH     + +P+ VE    K++   AV
Sbjct: 3235 FRLGHGSDVHVRKPQVVEGLRGKKIVHVAV 3264



 Score = 85.1 bits (209), Expect = 9e-17
 Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 40/191 (20%)

Query: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGW--HSV 223
           G+ ++  + A G++++WG G +G+LGHG+ E E  P L+  L+GL + +VA G     ++
Sbjct: 559 GSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTL 618

Query: 224 CVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAP 283
            V+E G ++ WG                              DG   K   G  DG   P
Sbjct: 619 AVTENGQVWSWG------------------------------DGDYGKLGRGGSDGCKTP 648

Query: 284 FIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRP 343
                    L++     D VK  CGS+ +  +T+ G++Y+WG G   +LGH     +  P
Sbjct: 649 --------KLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYP 700

Query: 344 RRVEYFVDKQL 354
           + +E    K++
Sbjct: 701 KLLEGLQGKKV 711



 Score = 78.6 bits (192), Expect = 9e-15
 Identities = 57/219 (26%), Positives = 96/219 (43%), Gaps = 43/219 (19%)

Query: 147  RAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELE-PRLLE 205
            + P +      L   Q+  G++    +   G+V++ G   +G+LG G     +  PR + 
Sbjct: 2981 KVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQIT 3040

Query: 206  ALQGLVMAEVA--AGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATEL 263
            AL   V+ +VA  +GG H+  ++  G ++ WG  + G+L                  + +
Sbjct: 3041 ALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLG---------------HFSRM 3085

Query: 264  NEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYT 323
            N D                        P L++          +CGS H+A +T +GELYT
Sbjct: 3086 NCDK-----------------------PRLIEALKTKRIRDIACGSSHSAALTSSGELYT 3122

Query: 324  WGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
            WG G+YG+LGH D T+  +P+ V+  +    +V  V CG
Sbjct: 3123 WGLGEYGRLGHGDNTTQLKPKMVKVLLGH--RVIQVACG 3159



 Score = 77.8 bits (190), Expect = 1e-14
 Identities = 57/225 (25%), Positives = 105/225 (46%), Gaps = 28/225 (12%)

Query: 159  RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG 218
            R R +  G+ H+  L ++G++++WG G +G+LGHG    +L+P++++ L G  + +VA G
Sbjct: 3100 RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACG 3159

Query: 219  GW--HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDG--------- 267
                 ++ +++ G ++ WG  + G+L         +G  + +    LN  G         
Sbjct: 3160 SRDAQTLALTDEGLVFSWGDGDFGKLGRG----GSEGCNIPQNIERLNGQGVCQIECGAQ 3215

Query: 268  -------SQVKRTGGAEDG---APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTR 317
                   S V  T G  D         + V+  P +++   G   V  + G+ H   VT 
Sbjct: 3216 FSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCLAVTD 3274

Query: 318  TGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
            +G++Y WG   +GQ G+  TT   +P  V+    +  ++  V CG
Sbjct: 3275 SGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--KITRVACG 3317



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 62/233 (26%), Positives = 102/233 (43%), Gaps = 19/233 (8%)

Query: 15  CGFGQELGSGRGRQVHSPSPL------RAGVDICRVSASWSYTAFVTRGGRLELSGSASG 68
           CG G  LG G    +  P  +      +AG  +  ++   +Y+A +T  G L   G   G
Sbjct: 521 CGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWG--RG 578

Query: 69  AAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGE 128
             GR     + +  + +L AG     ++ V             AQ +     G+    G+
Sbjct: 579 NYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGD-------AQTLAVTENGQVWSWGD 631

Query: 129 AQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHG 188
              G+L            + P       +L   ++  G++ ++ L   GQV+SWG G + 
Sbjct: 632 GDYGKLG----RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQ 687

Query: 189 QLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQ 241
           +LGHGT E    P+LLE LQG  + +VAAG  H + ++E  +++ WG N+  Q
Sbjct: 688 RLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 50/175 (28%), Positives = 74/175 (42%), Gaps = 38/175 (21%)

Query: 199 LEPRLLEALQGLVMAEVAA--GGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETV 256
           L P+L++ L    + ++AA   G H + ++ TG++Y WG  + G+L          G+TV
Sbjct: 482 LAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLG--------HGDTV 533

Query: 257 AREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVT 316
             E  ++                            A      G   V  +CGS ++A +T
Sbjct: 534 PLEEPKV--------------------------ISAFSGKQAGKHVVHIACGSTYSAAIT 567

Query: 317 RTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAV 371
             GELYTWG G YG+LGH  +     P  V     K L+V  V CG  +    AV
Sbjct: 568 AEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGL--KGLKVIDVACGSGDAQTLAV 620



 Score = 55.5 bits (132), Expect = 8e-08
 Identities = 25/59 (42%), Positives = 36/59 (61%)

Query: 165  LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSV 223
            +GA H L +  +GQV++WG   HGQ G+GT     +P L++ L+G  +  VA G  HSV
Sbjct: 3264 VGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3322


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score =  114 bits (285), Expect = 1e-25
 Identities = 73/226 (32%), Positives = 110/226 (48%), Gaps = 41/226 (18%)

Query: 151 YRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQG 209
           +  +  E +  Q+  G  H+L L   G++F+WG   HGQLG G    +   P+++E L G
Sbjct: 131 FESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAG 190

Query: 210 LVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQ 269
           + +A+++AG  HS+ +S +G+IY WG NE GQL L        G T +++   L E    
Sbjct: 191 VPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGL--------GHTESKDDPSLIE---- 238

Query: 270 VKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKY 329
                   D     F+A                    CG  H+A++T+ G L+T+G GK+
Sbjct: 239 ------GLDNQKVEFVA--------------------CGGSHSALLTQDGLLFTFGAGKH 272

Query: 330 GQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
           GQLGH  T +  RP  V   V    +V  + CG W+T  Y  + GK
Sbjct: 273 GQLGHNSTQNELRPCLVAELVG--YRVTQIACGRWHTLAYVSDLGK 316



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 31/78 (39%), Positives = 49/78 (62%), Gaps = 1/78 (1%)

Query: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVC- 224
           G  H+ LL   G +F++G G+HGQLGH + + EL P L+  L G  + ++A G WH++  
Sbjct: 251 GGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAY 310

Query: 225 VSETGDIYIWGWNESGQL 242
           VS+ G ++ +G  + GQL
Sbjct: 311 VSDLGKVFSFGSGKDGQL 328


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score =  105 bits (261), Expect = 9e-23
 Identities = 67/214 (31%), Positives = 96/214 (44%), Gaps = 41/214 (19%)

Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQGLVMAEVAAGGW 220
           Q+  G  H L L A GQ F+WG   HGQLG G    ++  P+ + +L+G+ +A+VAAGG 
Sbjct: 141 QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGA 200

Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
           HS  +S +G ++ WG N +GQL L      E                             
Sbjct: 201 HSFALSLSGAVFGWGMNNAGQLGLSDEKDRES---------------------------- 232

Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSL 340
                     P  + L      V  SCG  HTAV+T++G ++T+G G  GQLGH+     
Sbjct: 233 ----------PCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDE 282

Query: 341 DRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
             PRRV   +    +V  + CG  +T  +    G
Sbjct: 283 VNPRRVLELMGS--EVTQIACGRQHTLAFVPSSG 314



 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 61/234 (26%), Positives = 95/234 (40%), Gaps = 28/234 (11%)

Query: 161 RQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAE-LEPRLLEALQGLVMAEVAAGG 219
           +++  G  H++ L   G+V++ G    GQLGH   E E  +P  + AL    +  VA G 
Sbjct: 37  KEVACGGNHSVFLLEDGEVYTCGLNTKGQLGH---EREGNKPEQIGALADQHIIHVACGE 93

Query: 220 WHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG---- 275
            HS+ +S+ G ++ WG    GQL L T    ED   V R   +LN+        G     
Sbjct: 94  SHSLALSDRGQLFSWGAGSDGQLGLMT---TEDSVAVPRLIQKLNQQTILQVSCGNWHCL 150

Query: 276 --AEDG-------------APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGE 320
             A DG                     Q  P  +    G    + + G  H+  ++ +G 
Sbjct: 151 ALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA 210

Query: 321 LYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
           ++ WG    GQLG  D    + P  V+    +  +V  ++CG  +T V     G
Sbjct: 211 VFGWGMNNAGQLGLSDEKDRESPCHVKLL--RTQKVVYISCGEEHTAVLTKSGG 262



 Score = 61.2 bits (147), Expect = 1e-09
 Identities = 79/339 (23%), Positives = 133/339 (39%), Gaps = 60/339 (17%)

Query: 15  CGFGQELGSGRGRQVHSPSPLRAGVD--ICRVSASWSYTAFVTRGGRLELSGSAS-GAAG 71
           CG   +   G  R+ + P  + A  D  I  V+   S++  ++  G+L   G+ S G  G
Sbjct: 58  CGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117

Query: 72  --RCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEA 129
               +D+ A   L+  L      + +LQV            W   +   A+G+    G+ 
Sbjct: 118 LMTTEDSVAVPRLIQKLNQ----QTILQVSCGN--------W-HCLALAADGQFFTWGKN 164

Query: 130 QAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQ 189
             G+L L    + + S  +P        +   Q+  G  H+  L  +G VF WG    GQ
Sbjct: 165 SHGQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQ 221

Query: 190 LGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNL 249
           LG    +    P  ++ L+   +  ++ G  H+  ++++G ++ +G    GQL   + N 
Sbjct: 222 LGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMN- 280

Query: 250 AEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGS 309
               E   R   EL                                  MGS+  + +CG 
Sbjct: 281 ---DEVNPRRVLEL----------------------------------MGSEVTQIACGR 303

Query: 310 RHT-AVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
           +HT A V  +G +Y +G G  GQLG   T ++  P  V+
Sbjct: 304 QHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVK 342



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 49/194 (25%), Positives = 77/194 (39%), Gaps = 45/194 (23%)

Query: 182 WGGGRHGQLGHGTLEAEL--EPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNES 239
           WG    GQ G  T    +  EP++   +    + EVA GG HSV + E G++Y  G N  
Sbjct: 4   WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63

Query: 240 GQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMG 299
           GQL                       +G++ ++ G   D                     
Sbjct: 64  GQLG-------------------HEREGNKPEQIGALAD--------------------- 83

Query: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDT-TSLDRPRRVEYFVDKQLQVKA 358
              +  +CG  H+  ++  G+L++WG G  GQLG   T  S+  PR ++     Q  +  
Sbjct: 84  QHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKL--NQQTILQ 141

Query: 359 VTCGPWNTYVYAVE 372
           V+CG W+    A +
Sbjct: 142 VSCGNWHCLALAAD 155


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score =  101 bits (251), Expect = 1e-21
 Identities = 69/226 (30%), Positives = 103/226 (45%), Gaps = 51/226 (22%)

Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQGLVMAEV 215
           +++  Q+  G  H+L L    QVFSWG   HGQLG G    ++  P+ + +L+G+ +A+V
Sbjct: 127 DIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQV 186

Query: 216 AAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG 275
           AAGG HS  +S  G  + WG N +GQLAL  RN+                          
Sbjct: 187 AAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNV-------------------------- 220

Query: 276 AEDGAPAPFIAVQPFPALLDLPMGSDAVK------ASCGSRHTAVVTRTGELYTWGWGKY 329
                          P   + P+   A+K       SCG  HTAV+T+ G+++T+G  + 
Sbjct: 221 ---------------PVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRS 265

Query: 330 GQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
           GQLG+  T     P+ VE        V  + CG ++T  Y    G+
Sbjct: 266 GQLGYSPTPEKRGPQLVERI---DGLVSQIDCGSYHTLAYVHTTGQ 308



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 51/194 (26%), Positives = 81/194 (41%), Gaps = 40/194 (20%)

Query: 155 APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGH-GTLEAELEPRLLEALQGLVMA 213
           +P     Q   G  H+LLL    +V S G    GQLG  G    EL P  ++AL+ L++ 
Sbjct: 20  SPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL-PEPIQALETLIVD 78

Query: 214 EVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRT 273
            V+ G  HS+ V   G ++ WG    GQL +                 E  E     K+ 
Sbjct: 79  LVSCGKEHSLAVCHKGRVFAWGAGSEGQLGI----------------GEFKEISFTPKK- 121

Query: 274 GGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
                              L D+ +    ++ SCG  H+  +++  ++++WG   +GQLG
Sbjct: 122 ----------------IMTLNDIKI----IQVSCGHYHSLALSKDSQVFSWGKNSHGQLG 161

Query: 334 -HEDTTSLDRPRRV 346
             ++  S   P+RV
Sbjct: 162 LGKEFPSQASPQRV 175



 Score = 46.2 bits (108), Expect = 5e-05
 Identities = 25/78 (32%), Positives = 43/78 (55%), Gaps = 2/78 (2%)

Query: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
           +  G  H  +L   G+VF++G  R GQLG+     +  P+L+E + GLV +++  G +H+
Sbjct: 241 ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLV-SQIDCGSYHT 299

Query: 223 VC-VSETGDIYIWGWNES 239
           +  V  TG +  +G   S
Sbjct: 300 LAYVHTTGQVVSFGHGPS 317



 Score = 40.8 bits (94), Expect = 0.002
 Identities = 39/175 (22%), Positives = 65/175 (37%), Gaps = 41/175 (23%)

Query: 193 GTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED 252
           G    EL+ R      G  + + A+G  HS+ +     +   G N  GQL          
Sbjct: 6   GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLG--------- 56

Query: 253 GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHT 312
                              R G      P P  A++    ++DL         SCG  H+
Sbjct: 57  -------------------RRGAQRGELPEPIQALETL--IVDL--------VSCGKEHS 87

Query: 313 AVVTRTGELYTWGWGKYGQLGHEDTTSLD-RPRRVEYFVDKQLQVKAVTCGPWNT 366
             V   G ++ WG G  GQLG  +   +   P+++    D  +++  V+CG +++
Sbjct: 88  LAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLND--IKIIQVSCGHYHS 140



 Score = 30.4 bits (67), Expect = 2.7
 Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 5/70 (7%)

Query: 7   GAWFGFGFCGFGQELGSGRGRQVHSPSPLRAG----VDICRVSASWSYTAFVTRGGRLEL 62
           G  FG+G    GQ   SGR   V S  PL  G    + +  +S   ++TA +T+ G++  
Sbjct: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFT 259

Query: 63  SG-SASGAAG 71
            G + SG  G
Sbjct: 260 FGDNRSGQLG 269


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score =  100 bits (248), Expect = 3e-21
 Identities = 68/220 (30%), Positives = 102/220 (46%), Gaps = 41/220 (18%)

Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQGLVMAEV 215
           +++  Q+  G  H+L L  A +VF WG  ++GQLG GT  + +  P+LL++L G+   +V
Sbjct: 136 DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQV 195

Query: 216 AAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG 275
           AAGG HS  ++ +G I+ WG N+ GQL                    LN++  +      
Sbjct: 196 AAGGAHSFVLTLSGAIFGWGRNKFGQLG-------------------LNDENDRY----- 231

Query: 276 AEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
                          P LL        V   CG  HTA +T+ G ++T+G G YGQLGH 
Sbjct: 232 --------------VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277

Query: 336 DTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
            T+    PR+V  F      V  + CG  +T  +    G+
Sbjct: 278 STSHEINPRKV--FELMGSIVTEIACGRQHTSAFVPSSGR 315



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 58/235 (24%), Positives = 99/235 (42%), Gaps = 26/235 (11%)

Query: 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG 218
           R R +  G  H + +   G V++ G    GQLGH   ++  +P  + AL    +  V+ G
Sbjct: 35  RVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE--KSRKKPEQVVALDAQNIVAVSCG 92

Query: 219 GWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNE------------- 265
             H++ +++ G +Y WG +  GQL L     +E+   V R    L++             
Sbjct: 93  EAHTLALNDKGQVYAWGLDSDGQLGLVG---SEECIRVPRNIKSLSDIQIVQVACGYYHS 149

Query: 266 ----DGSQVKRTGGAEDG--APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTG 319
                 S+V   G  + G          Q  P LL   +G   ++ + G  H+ V+T +G
Sbjct: 150 LALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSG 209

Query: 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
            ++ WG  K+GQLG  D      P  ++    +  ++  + CG  +T     E G
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL--RSQKIVYICCGEDHTAALTKEGG 262



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 50/168 (29%), Positives = 76/168 (45%), Gaps = 17/168 (10%)

Query: 182 WGGGRHGQLGHGTLEAE--LEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNES 239
           WG    GQLG G ++ E  LEPR  +      + +V  G  H+V V + G +Y  G N+ 
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 240 GQLA------LPTRNLAEDGETVAR------EATELNEDGSQVKRTGGAEDGAPAPFIAV 287
           GQL        P + +A D + +            LN+ G QV   G   DG      + 
Sbjct: 64  GQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKG-QVYAWGLDSDGQLGLVGSE 122

Query: 288 QPFPALLDLPMGSDA--VKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
           +      ++   SD   V+ +CG  H+  +++  E++ WG  KYGQLG
Sbjct: 123 ECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 31/78 (39%), Positives = 44/78 (56%), Gaps = 1/78 (1%)

Query: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH-SVC 224
           G +H   L   G VF++G G +GQLGH +   E+ PR +  L G ++ E+A G  H S  
Sbjct: 250 GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAF 309

Query: 225 VSETGDIYIWGWNESGQL 242
           V  +G IY +G   +GQL
Sbjct: 310 VPSSGRIYSFGLGGNGQL 327


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score =  100 bits (248), Expect = 3e-21
 Identities = 68/220 (30%), Positives = 102/220 (46%), Gaps = 41/220 (18%)

Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQGLVMAEV 215
           +++  Q+  G  H+L L  A +VF WG  ++GQLG GT  + +  P+LL++L G+   +V
Sbjct: 136 DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQV 195

Query: 216 AAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG 275
           AAGG HS  ++ +G I+ WG N+ GQL                    LN++  +      
Sbjct: 196 AAGGAHSFVLTLSGAIFGWGRNKFGQLG-------------------LNDENDRY----- 231

Query: 276 AEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
                          P LL        V   CG  HTA +T+ G ++T+G G YGQLGH 
Sbjct: 232 --------------VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277

Query: 336 DTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
            T+    PR+V  F      V  + CG  +T  +    G+
Sbjct: 278 STSHEINPRKV--FELMGSIVTEIACGRQHTSAFVPSSGR 315



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 58/235 (24%), Positives = 99/235 (42%), Gaps = 26/235 (11%)

Query: 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG 218
           R R +  G  H + +   G V++ G    GQLGH   ++  +P  + AL    +  V+ G
Sbjct: 35  RVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE--KSRKKPEQVVALDAQNIVAVSCG 92

Query: 219 GWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNE------------- 265
             H++ +++ G +Y WG +  GQL L     +E+   V R    L++             
Sbjct: 93  EAHTLALNDKGQVYAWGLDSDGQLGLVG---SEECIRVPRNIKSLSDIQIVQVACGYYHS 149

Query: 266 ----DGSQVKRTGGAEDG--APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTG 319
                 S+V   G  + G          Q  P LL   +G   ++ + G  H+ V+T +G
Sbjct: 150 LALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSG 209

Query: 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
            ++ WG  K+GQLG  D      P  ++    +  ++  + CG  +T     E G
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL--RSQKIVYICCGEDHTAALTKEGG 262



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 50/168 (29%), Positives = 76/168 (45%), Gaps = 17/168 (10%)

Query: 182 WGGGRHGQLGHGTLEAE--LEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNES 239
           WG    GQLG G ++ E  LEPR  +      + +V  G  H+V V + G +Y  G N+ 
Sbjct: 4   WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63

Query: 240 GQLA------LPTRNLAEDGETVAR------EATELNEDGSQVKRTGGAEDGAPAPFIAV 287
           GQL        P + +A D + +            LN+ G QV   G   DG      + 
Sbjct: 64  GQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKG-QVYAWGLDSDGQLGLVGSE 122

Query: 288 QPFPALLDLPMGSDA--VKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
           +      ++   SD   V+ +CG  H+  +++  E++ WG  KYGQLG
Sbjct: 123 ECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170



 Score = 59.7 bits (143), Expect = 4e-09
 Identities = 31/78 (39%), Positives = 44/78 (56%), Gaps = 1/78 (1%)

Query: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH-SVC 224
           G +H   L   G VF++G G +GQLGH +   E+ PR +  L G ++ E+A G  H S  
Sbjct: 250 GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAF 309

Query: 225 VSETGDIYIWGWNESGQL 242
           V  +G IY +G   +GQL
Sbjct: 310 VPSSGRIYSFGLGGNGQL 327


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 62/193 (32%), Positives = 100/193 (51%), Gaps = 15/193 (7%)

Query: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGWHSVCVSE 227
           H L     G+VFSWG G +G+LGHG    +  P+L++  LQG V+  V+AG  HS  V+E
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTE 528

Query: 228 TGDIYIWGWNESGQLA--------LPT--RNLAEDGETV--AREATELNEDGSQVKRTGG 275
            G++Y WG  + G+L         +PT  ++++  GE    +     L++DG  V   GG
Sbjct: 529 DGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGG 588

Query: 276 AEDGAPAPFIAVQPF-PALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH 334
            ++G        + + P +++   G    K   GS+ +  +T TG++Y WG G     G 
Sbjct: 589 GDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGS 648

Query: 335 EDTTSLDRPRRVE 347
            + T+L RP+ +E
Sbjct: 649 SEATAL-RPKLIE 660



 Score = 90.9 bits (224), Expect = 2e-18
 Identities = 57/193 (29%), Positives = 97/193 (50%), Gaps = 15/193 (7%)

Query: 169  HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSET 228
            H++ L  +G+VFSWG G +G+LGHG  + +  PR +EALQG  + +++ G  HS  V+  
Sbjct: 4093 HSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 4152

Query: 229  GDIYIWGWNESGQLA--------LPTRNLAEDGETVAREATELNE------DGSQVKRTG 274
            G ++ +G  + G+L         LP R  A +G  + + A  LN       DGS V   G
Sbjct: 4153 GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212

Query: 275  GAEDG-APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
              + G         +  P  +D+  G    K +CG++ +  +T+ G +YT+G  +   L 
Sbjct: 4213 DGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLP 4272

Query: 334  HEDTTSLDRPRRV 346
                 + +RP+++
Sbjct: 4273 EGRARNHNRPQQI 4285



 Score = 80.5 bits (197), Expect = 2e-15
 Identities = 65/237 (27%), Positives = 105/237 (44%), Gaps = 56/237 (23%)

Query: 129  AQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHG 188
            A+AGR  ++P A       AP +       +A+Q+  G     ++ A G V + G G +G
Sbjct: 4011 AEAGRNVMVPAA-------APSFS------QAQQVICGQNCTFVIQANGTVLACGEGSYG 4057

Query: 189  QLGHGTLEAELEPRLLEALQGLVMAEV---AAGGWHSVCVSETGDIYIWGWNESGQLALP 245
            +LG G  +      ++ ALQG V+ ++        HS+ ++E+G+++ WG          
Sbjct: 4058 RLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG---------- 4107

Query: 246  TRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKA 305
                                DG   K   G  D         Q  P  ++   G + V+ 
Sbjct: 4108 --------------------DGDYGKLGHGNSDR--------QRRPRQIEALQGEEVVQM 4139

Query: 306  SCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
            SCG +H+AVVT  G+L+T+G G YG+LG  +T++   P RV     +  Q+  V CG
Sbjct: 4140 SCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTAL--EGYQIGQVACG 4194



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 62/207 (29%), Positives = 89/207 (42%), Gaps = 24/207 (11%)

Query: 178 QVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWN 237
           +V+ WG     QL  GT E  L+P+L  +       E  AG + +  +S  G +   G  
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIE--AGQYCTFVISTDGSVRACGKG 430

Query: 238 ESGQLALPTRN--------LAEDGETVAREATELNEDGSQVKRTGGAE-----DGAPAPF 284
             G+L L   N          E   ++ + ++    DG  +  T   E     DG     
Sbjct: 431 SYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKL 490

Query: 285 ----IAVQPFPALLDLPM-GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTS 339
                + Q +P L+  P+ G   V  S G RH+A VT  GELYTWG G +G+LGH D+ S
Sbjct: 491 GHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNS 550

Query: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366
               R +   V     V  V+CG  +T
Sbjct: 551 ----RNIPTLVKDISNVGEVSCGSSHT 573



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 49/187 (26%), Positives = 82/187 (43%), Gaps = 41/187 (21%)

Query: 162 QLELGAEHALLLDAAGQ-VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGW 220
           ++  G+ H + L   G+ V+S+GGG +G+LGHG      +P+++EALQG+ + +V AG  
Sbjct: 565 EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQ 624

Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
            S+ ++ TG +Y WG                     + EAT L                 
Sbjct: 625 SSLALTSTGQVYAWGCGACLGCG-------------SSEATALR---------------- 655

Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTS- 339
                     P L++    +  V  S G  H   ++   E+Y WG    GQ G  ++T  
Sbjct: 656 ----------PKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGP 705

Query: 340 LDRPRRV 346
           + +P++V
Sbjct: 706 ITKPKKV 712



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 55/220 (25%), Positives = 94/220 (42%), Gaps = 24/220 (10%)

Query: 162  QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
            Q+  G +H+ ++ + G++F++G G +G+LG G    +  P  + AL+G  + +VA G  H
Sbjct: 4138 QMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNH 4197

Query: 222  SVCVSETGD-IYIWGWNESGQLALPTRNLAEDGETV--------------AREATELNED 266
            ++ VS  G  ++ +G  + G+L L         + +               + +  L +D
Sbjct: 4198 TLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKD 4257

Query: 267  GSQV----KRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELY 322
            G        R  G  +G        Q  P L  + +   AV    G+ HT  +   G++Y
Sbjct: 4258 GHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAV----GAEHTLALASNGDVY 4313

Query: 323  TWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL-QVKAVTC 361
             WG    GQLG   T  +  P  V     K + Q+ A  C
Sbjct: 4314 AWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRC 4353



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 65/253 (25%), Positives = 109/253 (43%), Gaps = 23/253 (9%)

Query: 1    MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRA--GVDICRVSASWSYTAFVTRGG 58
            MA    G  F +G   +G+ LG G   +   P  + A  G ++ ++S  + ++A VT  G
Sbjct: 4095 MALTESGEVFSWGDGDYGK-LGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 4153

Query: 59   RLELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQN--VV 116
            +L   G+  G  GR      S   L        PE   +V A E    G+     N  + 
Sbjct: 4154 KLFTFGN--GDYGRLGLGNTSNKKL--------PE---RVTALEGYQIGQVACGLNHTLA 4200

Query: 117  PEAEGEDDPA-GEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDA 175
              A+G    A G+   G+L L        +  +P    +   +  +++  G + ++ L  
Sbjct: 4201 VSADGSMVWAFGDGDYGKLGL----GNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTK 4256

Query: 176  AGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
             G V+++G  R   L  G       P+ +  L G+++ +VA G  H++ ++  GD+Y WG
Sbjct: 4257 DGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWG 4316

Query: 236  WNESGQLALPTRN 248
             N  GQL L   N
Sbjct: 4317 SNSEGQLGLGHTN 4329



 Score = 57.4 bits (137), Expect = 2e-08
 Identities = 63/245 (25%), Positives = 100/245 (40%), Gaps = 35/245 (14%)

Query: 7   GAWFGFGFCGFGQELGSGRGRQVHSPS----PLRAGVDICRVSASWSYTAFVTRGGRLEL 62
           G  F +G   +G+ LG G       P     PL+  V +C VSA + ++A VT  G L  
Sbjct: 477 GEVFSWGDGDYGK-LGHGNSSTQKYPKLIQGPLQGKVVVC-VSAGYRHSAAVTEDGELYT 534

Query: 63  SGSAS-GAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEG 121
            G    G  G       +   L    +  G  +         +  G  +W+        G
Sbjct: 535 WGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFG-----GG 589

Query: 122 EDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPE----LRARQLELGAEHALLLDAAG 177
           ++   G     R+                Y+P   E    +  R++  G++ +L L + G
Sbjct: 590 DNGKLGHGDTNRV----------------YKPKVIEALQGMFIRKVCAGSQSSLALTSTG 633

Query: 178 QVFSWGGGRHGQLGHGTLEAE-LEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGW 236
           QV++WG G    LG G+ EA  L P+L+E L    + +V+ G  H + +S   ++Y WG 
Sbjct: 634 QVYAWGCG--ACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGN 691

Query: 237 NESGQ 241
           N  GQ
Sbjct: 692 NSMGQ 696



 Score = 53.1 bits (126), Expect = 4e-07
 Identities = 34/90 (37%), Positives = 46/90 (51%), Gaps = 1/90 (1%)

Query: 133  RLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGH 192
            RL  LP  RA    R P   P+   +    + +GAEH L L + G V++WG    GQLG 
Sbjct: 4267 RLIGLPEGRARNHNR-PQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGL 4325

Query: 193  GTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
            G      EP L+  LQG  + +++AG  HS
Sbjct: 4326 GHTNHVREPTLVTGLQGKNVRQISAGRCHS 4355



 Score = 42.7 bits (99), Expect = 5e-04
 Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 5/84 (5%)

Query: 145 SPRAPFYRP-LAPELRARQL---ELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199
           S  A   RP L  EL A ++    +G  H L L    +V++WG    GQ G G     + 
Sbjct: 648 SSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPIT 707

Query: 200 EPRLLEALQGLVMAEVAAGGWHSV 223
           +P+ +  L G+ + +++AG  HS+
Sbjct: 708 KPKKVSGLDGIAIQQISAGTSHSL 731


>gi|4557445 regulator of chromosome condensation and BTB domain
           containing protein 2 [Homo sapiens]
          Length = 551

 Score = 89.7 bits (221), Expect = 4e-18
 Identities = 55/198 (27%), Positives = 90/198 (45%), Gaps = 39/198 (19%)

Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHG-TLEAELEPRLLEALQGLVMAEVAAGGW 220
           ++  G+ H+L+L + G+VF+WG    GQ+G G T+   +  R+   LQ  V+  +A G  
Sbjct: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQM 215

Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
             + V +TG++Y+WG+N +GQL                    L   G+            
Sbjct: 216 CCMAVVDTGEVYVWGYNGNGQLG-------------------LGNSGN------------ 244

Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSL 340
                  QP P  +    G    + +CG  HT V+T  G++Y WG   YGQLG  + ++ 
Sbjct: 245 -------QPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQ 297

Query: 341 DRPRRVEYFVDKQLQVKA 358
             P  V    D+ +++ A
Sbjct: 298 SYPTPVTVEKDRIIEIAA 315



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 58/206 (28%), Positives = 86/206 (41%), Gaps = 42/206 (20%)

Query: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP-RLLEALQGLVMAEVAAGGWHSVCVSE 227
           H +L    G+VF+WG   + QLG+GT    L P  +   L    + EVA G +HS+ ++ 
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169

Query: 228 TGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAV 287
            G+++ WG+N SGQ+                        GS V                 
Sbjct: 170 DGEVFAWGYNNSGQVG----------------------SGSTVN---------------- 191

Query: 288 QPFPA-LLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRV 346
           QP P  +         V  +CG      V  TGE+Y WG+   GQLG  ++ +   P RV
Sbjct: 192 QPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRV 251

Query: 347 EYFVDKQLQVKAVTCGPWNTYVYAVE 372
                + ++V+ V CG  +T V   E
Sbjct: 252 AAL--QGIRVQRVACGYAHTLVLTDE 275



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 49/186 (26%), Positives = 80/186 (43%), Gaps = 39/186 (20%)

Query: 178 QVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG-GWHSVCVSETGDIYIWGW 236
           ++F  G    G LG G +++ +EPR L++L G  +A ++ G G H V  +  G+++ WG 
Sbjct: 66  EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125

Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDL 296
           N   QL   T N    G      +T L+                                
Sbjct: 126 NAYSQLGNGTTN---HGLVPCHISTNLSN------------------------------- 151

Query: 297 PMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQV 356
                 ++ +CGS H+ V+T  GE++ WG+   GQ+G   T +   PRRV   +  ++ V
Sbjct: 152 ---KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKV-V 207

Query: 357 KAVTCG 362
             + CG
Sbjct: 208 VTIACG 213



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 1/89 (1%)

Query: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAA 217
           +R +++  G  H L+L   GQV++WG   +GQLG G    +  P  +   +  ++   A 
Sbjct: 257 IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAAC 316

Query: 218 GGWH-SVCVSETGDIYIWGWNESGQLALP 245
              H S   ++ G +Y+WG      + LP
Sbjct: 317 HSTHTSAAKTQGGHVYMWGQCRGQSVILP 345



 Score = 37.4 bits (85), Expect = 0.022
 Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 2/79 (2%)

Query: 291 PALLDLPMGSDAVKASCGSR-HTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYF 349
           P  LD   G      S GS  H  + T  GE++TWG   Y QLG+  T     P  +   
Sbjct: 89  PRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTN 148

Query: 350 VDKQLQVKAVTCGPWNTYV 368
           +  + QV  V CG +++ V
Sbjct: 149 LSNK-QVIEVACGSYHSLV 166


>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 60/229 (26%)

Query: 167 AEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVS 226
           A H+LL+   G+++SWG    GQLGHG  +    PRL+E L   V+   A G  H++ ++
Sbjct: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218

Query: 227 ETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIA 286
           ETG ++ +G N+ GQL L                             G   D  P+P   
Sbjct: 219 ETGSVFAFGENKMGQLGL-----------------------------GNQTDAVPSPAQI 249

Query: 287 VQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH-EDTTSLDRPRR 345
           +           G    K +CG+  + ++   G LY++G  +YGQLGH  D   + R +R
Sbjct: 250 MY---------NGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300

Query: 346 VEY-----------FVDK----------QLQVKAVTCGPWNTYVYAVEK 373
           +EY           F++K           + V+ V CG  +T V   +K
Sbjct: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQK 349



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 32/82 (39%), Positives = 48/82 (58%), Gaps = 2/82 (2%)

Query: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQ--GLVMA 213
           P +  R +  GA H L+LD+  +VFSWG G +G+LGH   + E+ PRL++     G   +
Sbjct: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387

Query: 214 EVAAGGWHSVCVSETGDIYIWG 235
           ++ AG   S  VSE G ++ WG
Sbjct: 388 QIYAGYTCSFAVSEVGGLFFWG 409



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 19/45 (42%), Positives = 30/45 (66%), Gaps = 1/45 (2%)

Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
           V  SC + H+ ++T  G+L++WG  + GQLGH DT  ++ PR +E
Sbjct: 154 VSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 35/142 (24%), Positives = 63/142 (44%), Gaps = 32/142 (22%)

Query: 127 GEAQAGRLPLLPCARAYVSPRAPFY--RPLAPELRARQLELGAEHALLLDAAGQVFSWGG 184
           GE + G+L L     A  SP    Y  +P+       ++  GAE ++++D  G ++S+G 
Sbjct: 227 GENKMGQLGLGNQTDAVPSPAQIMYNGQPIT------KMACGAEFSMIMDCKGNLYSFGC 280

Query: 185 GRHGQLGHGT------------LEAELEPRLLE------------ALQGLVMAEVAAGGW 220
             +GQLGH +             + EL PR +              +  +V+ +VA G  
Sbjct: 281 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 340

Query: 221 HSVCVSETGDIYIWGWNESGQL 242
           H++ +     ++ WG+   G+L
Sbjct: 341 HTLVLDSQKRVFSWGFGGYGRL 362


>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 89.4 bits (220), Expect = 5e-18
 Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 60/229 (26%)

Query: 167 AEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVS 226
           A H+LL+   G+++SWG    GQLGHG  +    PRL+E L   V+   A G  H++ ++
Sbjct: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218

Query: 227 ETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIA 286
           ETG ++ +G N+ GQL L                             G   D  P+P   
Sbjct: 219 ETGSVFAFGENKMGQLGL-----------------------------GNQTDAVPSPAQI 249

Query: 287 VQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH-EDTTSLDRPRR 345
           +           G    K +CG+  + ++   G LY++G  +YGQLGH  D   + R +R
Sbjct: 250 MY---------NGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300

Query: 346 VEY-----------FVDK----------QLQVKAVTCGPWNTYVYAVEK 373
           +EY           F++K           + V+ V CG  +T V   +K
Sbjct: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQK 349



 Score = 63.9 bits (154), Expect = 2e-10
 Identities = 32/82 (39%), Positives = 48/82 (58%), Gaps = 2/82 (2%)

Query: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQ--GLVMA 213
           P +  R +  GA H L+LD+  +VFSWG G +G+LGH   + E+ PRL++     G   +
Sbjct: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387

Query: 214 EVAAGGWHSVCVSETGDIYIWG 235
           ++ AG   S  VSE G ++ WG
Sbjct: 388 QIYAGYTCSFAVSEVGGLFFWG 409



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 19/45 (42%), Positives = 30/45 (66%), Gaps = 1/45 (2%)

Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
           V  SC + H+ ++T  G+L++WG  + GQLGH DT  ++ PR +E
Sbjct: 154 VSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197



 Score = 43.9 bits (102), Expect = 2e-04
 Identities = 35/142 (24%), Positives = 63/142 (44%), Gaps = 32/142 (22%)

Query: 127 GEAQAGRLPLLPCARAYVSPRAPFY--RPLAPELRARQLELGAEHALLLDAAGQVFSWGG 184
           GE + G+L L     A  SP    Y  +P+       ++  GAE ++++D  G ++S+G 
Sbjct: 227 GENKMGQLGLGNQTDAVPSPAQIMYNGQPIT------KMACGAEFSMIMDCKGNLYSFGC 280

Query: 185 GRHGQLGHGT------------LEAELEPRLLE------------ALQGLVMAEVAAGGW 220
             +GQLGH +             + EL PR +              +  +V+ +VA G  
Sbjct: 281 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 340

Query: 221 HSVCVSETGDIYIWGWNESGQL 242
           H++ +     ++ WG+   G+L
Sbjct: 341 HTLVLDSQKRVFSWGFGGYGRL 362


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 60/214 (28%), Positives = 101/214 (47%), Gaps = 43/214 (20%)

Query: 160 ARQLELGAEHALLLDAAGQVFSW----GGGR-HGQLGHGTLEAELEPRLLEALQGLVMAE 214
           ARQ+  G  H  ++    ++++W    GG + HGQLGHG   +  +P+ +E LQG  + +
Sbjct: 371 ARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQ 430

Query: 215 VAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTG 274
           V+ G   +VCV++ G +Y +G +  G +                           V +  
Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGSDYYGCMG--------------------------VDKVA 464

Query: 275 GAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH 334
           G E         ++P    L+  + +   + SCG  H  V+TR  E+Y+WG G+YG+LG 
Sbjct: 465 GPE--------VLEPMQ--LNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL 514

Query: 335 EDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYV 368
           +       P++V+  V K L + AV CG   T++
Sbjct: 515 DSEEDYYTPQKVD--VPKALIIVAVQCGCDGTFL 546



 Score = 50.1 bits (118), Expect = 3e-06
 Identities = 43/172 (25%), Positives = 71/172 (41%), Gaps = 25/172 (14%)

Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
           Q+  G  H ++L    +V+SWG G +G+LG  + E    P+ ++  + L++  V  G   
Sbjct: 484 QVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDG 543

Query: 222 SVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAP 281
           +  ++++G +   G NE  +L L   N    G  +  EA        +V  T        
Sbjct: 544 TFLLTQSGKVLACGLNEFNKLGL---NQCMSG-IINHEAYH------EVPYTTSFTLAKQ 593

Query: 282 APFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
             F  ++                 + G  HTA +   G L T+G  K GQLG
Sbjct: 594 LSFYKIRTI---------------APGKTHTAAIDERGRLLTFGCNKCGQLG 630



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 14/78 (17%)

Query: 297 PMGSDAVKASCGSR-------HTAVVTRTGELYTW-----GWGKYGQLGHEDTTSLDRPR 344
           P   D +K+ C +R       H AVVT   ELYTW     G   +GQLGH D  S  +P+
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPK 418

Query: 345 RVEYFVDKQLQVKAVTCG 362
            VE    K   ++ V+CG
Sbjct: 419 HVEKLQGK--AIRQVSCG 434



 Score = 42.0 bits (97), Expect = 0.001
 Identities = 24/87 (27%), Positives = 43/87 (49%), Gaps = 1/87 (1%)

Query: 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAA 217
           + R +  G  H   +D  G++ ++G  + GQLG G  +  L   LL   L G  +  V+ 
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657

Query: 218 GGWHSVCVSETGDIYIWGWNESGQLAL 244
           G   ++  ++   I+ WG   +G+LA+
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAM 684


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score = 79.0 bits (193), Expect = 7e-15
 Identities = 80/312 (25%), Positives = 123/312 (39%), Gaps = 56/312 (17%)

Query: 109 PLWAQNVVPEAEGEDDPAGEAQAGRL-----PLLPCARAYVSPRAPFYRPLAPELRARQL 163
           P+    VV  A G    AG  ++GRL     P L      + P A       P+  +R L
Sbjct: 328 PMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGA--VEQPQPQFISRFL 385

Query: 164 E-----------LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVM 212
           E            G      L   G + ++G G +G LGHG+L    +P ++EAL G  M
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445

Query: 213 AEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRN------------------------ 248
            +VA G  H + +S   +++ WG  +SG+L L TR                         
Sbjct: 446 VQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGID 505

Query: 249 ----LAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQ---PFPALLDLPMGSD 301
               L   G+ +A  +   N+ G      G      P P   V+    F  L   P+  +
Sbjct: 506 SSMILTVPGQALACGSNRFNKLGLDHLSLG----EEPVPHQQVEEALSFTLLGSAPLDQE 561

Query: 302 -AVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360
             +    G+ H+A VT +G+ YT+G  ++GQLG         P +V+    + +++  V 
Sbjct: 562 PLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGL--EGIKMAMVA 619

Query: 361 CGPWNTYVYAVE 372
           CG   T     E
Sbjct: 620 CGDAFTVAIGAE 631



 Score = 62.8 bits (151), Expect = 5e-10
 Identities = 91/372 (24%), Positives = 134/372 (36%), Gaps = 80/372 (21%)

Query: 21  LGSGRGR----QVHSPSPL--------RAGVDICRVSASWSYTAFVTRGGRLELSGSASG 68
           LG+G G      V  P P         ++GV I  V+    +TA +T  G +   GS S 
Sbjct: 361 LGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSN 420

Query: 69  AAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGE 128
                       G L  +      EALL     + A     + A +     E E    G 
Sbjct: 421 GC-------LGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALST----ERELFAWGR 469

Query: 129 AQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHG 188
             +GRL L        S   P   P+ P   A+++  G + +++L   GQ  + G  R  
Sbjct: 470 GDSGRLGL----GTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFN 525

Query: 189 QLGHGTLEAELEP----RLLEALQGLVMA----------EVAAGGWHSVCVSETGDIYIW 234
           +LG   L    EP    ++ EAL   ++            +  G  HS  V+ +GD Y +
Sbjct: 526 KLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTF 585

Query: 235 GWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALL 294
           G N+ GQL   TR                   GS+          AP     ++      
Sbjct: 586 GSNQHGQLGTNTRR------------------GSR----------APCKVQGLE------ 611

Query: 295 DLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL 354
               G      +CG   T  +    E+Y+WG G  G+LG  D  +   PR V+       
Sbjct: 612 ----GIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDA-GLPRPVQLDETHPY 666

Query: 355 QVKAVTCGPWNT 366
            V +V+C   NT
Sbjct: 667 TVTSVSCCHGNT 678



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 44/157 (28%), Positives = 61/157 (38%), Gaps = 22/157 (14%)

Query: 231 IYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTG----------GAEDGA 280
           +Y WG      L LP  N     E V   A    + G  V R+G          GA  G+
Sbjct: 314 VYAWGGGLGTPLRLPMLNT----EVVQVAAGRTQKAG--VTRSGRLILWEAPPLGAGGGS 367

Query: 281 PAPFIAVQPFPAL----LDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHED 336
             P    QP P      L+   G      +CG   TA +T  G + T+G G  G LGH  
Sbjct: 368 LLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGS 427

Query: 337 TTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEK 373
            T + +P  VE  +    ++  V CG  +    + E+
Sbjct: 428 LTDISQPTIVEALLG--YEMVQVACGASHVLALSTER 462


>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
           sapiens]
          Length = 815

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 21/231 (9%)

Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
           E + +QL  G+  +  L   G++F WG    GQ+G   +     P+  +   G  ++ ++
Sbjct: 139 EHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWIS 196

Query: 217 AGGWHSVCVSETGDIYIWGWNESGQLALPTRNL---------AEDGETVAREA------T 261
            G +HS  V+  G++Y++G  E+G+L LP + L         +E  E V + A       
Sbjct: 197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV 256

Query: 262 ELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGEL 321
            L E+       G         F+     P +++          SCG  HTA++T  G +
Sbjct: 257 VLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316

Query: 322 YTWGWGKYGQ--LGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYA 370
           YT+G G++G+  LG E+ T+   P     F+  +  VK V CG  +  V+A
Sbjct: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFL--RFIVKLVACGGCHMVVFA 365



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 22/223 (9%)

Query: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
           L  G EH+ ++    +++ +G    GQLG G+  A  +P  ++AL+   +   A G  H+
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 223 VCVSETGDIYIWGWNESGQLAL---------------PTRNLAEDGETVAREATELNEDG 267
           +  +E G++Y  G N  GQL L                + +  +     +  +  L EDG
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 268 SQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWG 327
                   +E       ++    P    + +G      SCG  H+A VT  GELY +G  
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEP 217

Query: 328 KYGQLG--HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYV 368
           + G+LG  ++   +   P+ V    +K +Q   V CG  +T V
Sbjct: 218 ENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTVV 257



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 56/232 (24%), Positives = 101/232 (43%), Gaps = 23/232 (9%)

Query: 152 RPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQG-L 210
           + L PE + +    G  H L+    G V++ GG   GQLG G  E      ++       
Sbjct: 82  KALKPE-KVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEH 140

Query: 211 VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALP--TRNLAEDGETVAREATELN---- 264
            + +++AG   S  ++E G +++WG N  GQ+ L   +        T+ +  + ++    
Sbjct: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYY 200

Query: 265 ------EDGSQVKRTGGAED---GAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVV 315
                  DG ++   G  E+   G P   +     P L+   +    ++ +CG  HT V+
Sbjct: 201 HSAFVTTDG-ELYVFGEPENGKLGLPNQLLGNHRTPQLVS-EIPEKVIQVACGGEHTVVL 258

Query: 316 TRTGELYTWGWGKYGQLG-HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNT 366
           T    +YT+G G++GQLG          P+ +E   D+   +  ++CG  +T
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQ--TISYISCGENHT 307



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 5/130 (3%)

Query: 120 EGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQV 179
           +GE    GE + G+L L    +   + R P      PE +  Q+  G EH ++L     V
Sbjct: 208 DGELYVFGEPENGKLGLPN--QLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVL-TENAV 263

Query: 180 FSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
           +++G G+ GQLG GT   E  EP+++E ++   ++ ++ G  H+  +++ G +Y +G   
Sbjct: 264 YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGR 323

Query: 239 SGQLALPTRN 248
            G+L L   N
Sbjct: 324 HGKLGLGLEN 333



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 25/66 (37%), Positives = 36/66 (54%), Gaps = 2/66 (3%)

Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
           V  SCG  H+AVVT   +LY +G   +GQLG    +++ +P  V+    K  +VK   CG
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKAL--KPEKVKLAACG 95

Query: 363 PWNTYV 368
             +T V
Sbjct: 96  RNHTLV 101



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 50/204 (24%)

Query: 172 LLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDI 231
           L+  +G VF++G  +  +   G    + +          V   ++ G  HS  V+    +
Sbjct: 7   LMPDSGAVFTFGKSKFAENNPGKFWFKND----------VPVHLSCGDEHSAVVTGNNKL 56

Query: 232 YIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFP 291
           Y++G N  GQL L +++                                P    A++P  
Sbjct: 57  YMFGSNNWGQLGLGSKSAISK----------------------------PTCVKALKPEK 88

Query: 292 ALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVD 351
             L          A+CG  HT V T  G +Y  G    GQLG  DT   +    + +F  
Sbjct: 89  VKL----------AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTS 138

Query: 352 KQLQVKAVTCGPWNTYVYAVEKGK 375
           +  ++K ++ G  NT     E G+
Sbjct: 139 EH-KIKQLSAGS-NTSAALTEDGR 160


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 74.3 bits (181), Expect = 2e-13
 Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 21/231 (9%)

Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
           E + +QL  G+  +  L   G++F WG    GQ+G   +     P+  +   G  ++ ++
Sbjct: 139 EHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWIS 196

Query: 217 AGGWHSVCVSETGDIYIWGWNESGQLALPTRNL---------AEDGETVAREA------T 261
            G +HS  V+  G++Y++G  E+G+L LP + L         +E  E V + A       
Sbjct: 197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV 256

Query: 262 ELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGEL 321
            L E+       G         F+     P +++          SCG  HTA++T  G +
Sbjct: 257 VLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316

Query: 322 YTWGWGKYGQ--LGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYA 370
           YT+G G++G+  LG E+ T+   P     F+  +  VK V CG  +  V+A
Sbjct: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFL--RFIVKLVACGGCHMVVFA 365



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 22/223 (9%)

Query: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
           L  G EH+ ++    +++ +G    GQLG G+  A  +P  ++AL+   +   A G  H+
Sbjct: 40  LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99

Query: 223 VCVSETGDIYIWGWNESGQLAL---------------PTRNLAEDGETVAREATELNEDG 267
           +  +E G++Y  G N  GQL L                + +  +     +  +  L EDG
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159

Query: 268 SQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWG 327
                   +E       ++    P    + +G      SCG  H+A VT  GELY +G  
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEP 217

Query: 328 KYGQLG--HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYV 368
           + G+LG  ++   +   P+ V    +K +Q   V CG  +T V
Sbjct: 218 ENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTVV 257



 Score = 60.1 bits (144), Expect = 3e-09
 Identities = 56/232 (24%), Positives = 101/232 (43%), Gaps = 23/232 (9%)

Query: 152 RPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQG-L 210
           + L PE + +    G  H L+    G V++ GG   GQLG G  E      ++       
Sbjct: 82  KALKPE-KVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEH 140

Query: 211 VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALP--TRNLAEDGETVAREATELN---- 264
            + +++AG   S  ++E G +++WG N  GQ+ L   +        T+ +  + ++    
Sbjct: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYY 200

Query: 265 ------EDGSQVKRTGGAED---GAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVV 315
                  DG ++   G  E+   G P   +     P L+   +    ++ +CG  HT V+
Sbjct: 201 HSAFVTTDG-ELYVFGEPENGKLGLPNQLLGNHRTPQLVS-EIPEKVIQVACGGEHTVVL 258

Query: 316 TRTGELYTWGWGKYGQLG-HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNT 366
           T    +YT+G G++GQLG          P+ +E   D+   +  ++CG  +T
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQ--TISYISCGENHT 307



 Score = 49.3 bits (116), Expect = 6e-06
 Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 5/130 (3%)

Query: 120 EGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQV 179
           +GE    GE + G+L L    +   + R P      PE +  Q+  G EH ++L     V
Sbjct: 208 DGELYVFGEPENGKLGLPN--QLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVL-TENAV 263

Query: 180 FSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
           +++G G+ GQLG GT   E  EP+++E ++   ++ ++ G  H+  +++ G +Y +G   
Sbjct: 264 YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGR 323

Query: 239 SGQLALPTRN 248
            G+L L   N
Sbjct: 324 HGKLGLGLEN 333



 Score = 44.7 bits (104), Expect = 1e-04
 Identities = 25/66 (37%), Positives = 36/66 (54%), Gaps = 2/66 (3%)

Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
           V  SCG  H+AVVT   +LY +G   +GQLG    +++ +P  V+    K  +VK   CG
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKAL--KPEKVKLAACG 95

Query: 363 PWNTYV 368
             +T V
Sbjct: 96  RNHTLV 101



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 50/204 (24%)

Query: 172 LLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDI 231
           L+  +G VF++G  +  +   G    + +          V   ++ G  HS  V+    +
Sbjct: 7   LMPDSGAVFTFGKSKFAENNPGKFWFKND----------VPVHLSCGDEHSAVVTGNNKL 56

Query: 232 YIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFP 291
           Y++G N  GQL L +++                                P    A++P  
Sbjct: 57  YMFGSNNWGQLGLGSKSAISK----------------------------PTCVKALKPEK 88

Query: 292 ALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVD 351
             L          A+CG  HT V T  G +Y  G    GQLG  DT   +    + +F  
Sbjct: 89  VKL----------AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTS 138

Query: 352 KQLQVKAVTCGPWNTYVYAVEKGK 375
           +  ++K ++ G  NT     E G+
Sbjct: 139 EH-KIKQLSAGS-NTSAALTEDGR 160


>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
           (POZ) domain containing protein 1 [Homo sapiens]
          Length = 531

 Score = 72.4 bits (176), Expect = 6e-13
 Identities = 57/230 (24%), Positives = 93/230 (40%), Gaps = 34/230 (14%)

Query: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP-RLLEALQGLVMAEVAAGGWHSVCVSE 227
           H LL    G V++WG   + QLG+GT    + P ++   L    + EVA G  HS+ ++ 
Sbjct: 86  HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145

Query: 228 TGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAV 287
            G+++ WG+N  GQ+          G T  +       +   +KR  G   G  +    +
Sbjct: 146 DGEVFAWGYNNCGQVG--------SGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVL 197

Query: 288 Q-------PFPALLDLPMGSDAVKAS----------------CGSRHTAVVTRTGELYTW 324
                    +     L +G++  + +                CG  HT  +T  G LY W
Sbjct: 198 DNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAW 257

Query: 325 GWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
           G   YGQLG  +  +L  P  +   V+K+  V+   C   +T     + G
Sbjct: 258 GANTYGQLGTGNKNNLLSPAHI--MVEKERVVEIAACHSAHTSAAKTQGG 305



 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 1/85 (1%)

Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
           Q+  G  H L L   G +++WG   +GQLG G     L P  +   +  V+   A    H
Sbjct: 237 QIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAH 296

Query: 222 -SVCVSETGDIYIWGWNESGQLALP 245
            S   ++ G +Y+WG      + LP
Sbjct: 297 TSAAKTQGGHVYMWGQCRGQSVILP 321


>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
           sapiens]
          Length = 452

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 67/223 (30%), Positives = 96/223 (43%), Gaps = 43/223 (19%)

Query: 141 RAYVSPRAPFYR-------PLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHG 193
           RA  S R P  R       P  P+ + R +     H       G V + G G  GQLG G
Sbjct: 27  RAAASRRVPGARSCQGACGPSPPDQKTRPVS----HRSHSTEPGLVLTLGQGDVGQLGLG 82

Query: 194 TLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED 252
               E + P L+   + +V AE  AGG H+VC+S++G +Y +G N+ G L    R+ + +
Sbjct: 83  ENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFGCNDEGALG---RDTSVE 137

Query: 253 GETVAREATELNEDGSQVK---------------------RTGGAEDGAPAPF-IAVQPF 290
           G  +     EL E   QV                      R      G   P   ++ P 
Sbjct: 138 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 197

Query: 291 PALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
              LD+P+    VK + G+ H  ++T  G+LYT G G+ GQLG
Sbjct: 198 QVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 236



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)

Query: 16  GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
           G   E   GR   V      P  +     + +VSA  S+TA +T  GR+ L GS      
Sbjct: 123 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 177

Query: 72  RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
             +D     GLL  ++    P +  L V   + A   + L    V+  A+G+    G  +
Sbjct: 178 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 231

Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
            G+L  +P   A    R    R L P+            +R +    GA     +   G 
Sbjct: 232 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 291

Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
           V+ +G   + QLG    E+   P+ L + +    + V  + G  H+VC+   G  Y  G 
Sbjct: 292 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 351

Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
            E G+L L        GE                    GAE+         +  P L+  
Sbjct: 352 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 374

Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
           LP  S     +CG+     VT+ G ++ WG G   QLG         P  VE  + KQL+
Sbjct: 375 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 428

Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
              V +V+ G  +T +   +K +S
Sbjct: 429 NRVVLSVSSGGQHTVLLVKDKEQS 452


>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
           sapiens]
          Length = 438

 Score = 68.6 bits (166), Expect = 9e-12
 Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)

Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
           G V + G G  GQLG G    E + P L+   + +V AE  AGG H+VC+S++G +Y +G
Sbjct: 52  GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 109

Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
            N+ G L    R+ + +G  +     EL E   QV                      R  
Sbjct: 110 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 166

Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
               G   P   ++ P    LD+P+    VK + G+ H  ++T  G+LYT G G+ GQLG
Sbjct: 167 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 222



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)

Query: 16  GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
           G   E   GR   V      P  +     + +VSA  S+TA +T  GR+ L GS      
Sbjct: 109 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 163

Query: 72  RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
             +D     GLL  ++    P +  L V   + A   + L    V+  A+G+    G  +
Sbjct: 164 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 217

Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
            G+L  +P   A    R    R L P+            +R +    GA     +   G 
Sbjct: 218 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 277

Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
           V+ +G   + QLG    E+   P+ L + +    + V  + G  H+VC+   G  Y  G 
Sbjct: 278 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 337

Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
            E G+L L        GE                    GAE+         +  P L+  
Sbjct: 338 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 360

Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
           LP  S     +CG+     VT+ G ++ WG G   QLG         P  VE  + KQL+
Sbjct: 361 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 414

Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
              V +V+ G  +T +   +K +S
Sbjct: 415 NRVVLSVSSGGQHTVLLVKDKEQS 438


>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
           sapiens]
          Length = 421

 Score = 68.6 bits (166), Expect = 9e-12
 Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)

Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
           G V + G G  GQLG G    E + P L+   + +V AE  AGG H+VC+S++G +Y +G
Sbjct: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92

Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
            N+ G L    R+ + +G  +     EL E   QV                      R  
Sbjct: 93  CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149

Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
               G   P   ++ P    LD+P+    VK + G+ H  ++T  G+LYT G G+ GQLG
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)

Query: 16  GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
           G   E   GR   V      P  +     + +VSA  S+TA +T  GR+ L GS      
Sbjct: 92  GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146

Query: 72  RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
             +D     GLL  ++    P +  L V   + A   + L    V+  A+G+    G  +
Sbjct: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200

Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
            G+L  +P   A    R    R L P+            +R +    GA     +   G 
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260

Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
           V+ +G   + QLG    E+   P+ L + +    + V  + G  H+VC+   G  Y  G 
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320

Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
            E G+L L        GE                    GAE+         +  P L+  
Sbjct: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343

Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
           LP  S     +CG+     VT+ G ++ WG G   QLG         P  VE  + KQL+
Sbjct: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397

Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
              V +V+ G  +T +   +K +S
Sbjct: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421


>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 68.6 bits (166), Expect = 9e-12
 Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)

Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
           G V + G G  GQLG G    E + P L+   + +V AE  AGG H+VC+S++G +Y +G
Sbjct: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92

Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
            N+ G L    R+ + +G  +     EL E   QV                      R  
Sbjct: 93  CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149

Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
               G   P   ++ P    LD+P+    VK + G+ H  ++T  G+LYT G G+ GQLG
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)

Query: 16  GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
           G   E   GR   V      P  +     + +VSA  S+TA +T  GR+ L GS      
Sbjct: 92  GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146

Query: 72  RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
             +D     GLL  ++    P +  L V   + A   + L    V+  A+G+    G  +
Sbjct: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200

Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
            G+L  +P   A    R    R L P+            +R +    GA     +   G 
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260

Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
           V+ +G   + QLG    E+   P+ L + +    + V  + G  H+VC+   G  Y  G 
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320

Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
            E G+L L        GE                    GAE+         +  P L+  
Sbjct: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343

Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
           LP  S     +CG+     VT+ G ++ WG G   QLG         P  VE  + KQL+
Sbjct: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397

Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
              V +V+ G  +T +   +K +S
Sbjct: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421


>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 68.6 bits (166), Expect = 9e-12
 Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)

Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
           G V + G G  GQLG G    E + P L+   + +V AE  AGG H+VC+S++G +Y +G
Sbjct: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92

Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
            N+ G L    R+ + +G  +     EL E   QV                      R  
Sbjct: 93  CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149

Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
               G   P   ++ P    LD+P+    VK + G+ H  ++T  G+LYT G G+ GQLG
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)

Query: 16  GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
           G   E   GR   V      P  +     + +VSA  S+TA +T  GR+ L GS      
Sbjct: 92  GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146

Query: 72  RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
             +D     GLL  ++    P +  L V   + A   + L    V+  A+G+    G  +
Sbjct: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200

Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
            G+L  +P   A    R    R L P+            +R +    GA     +   G 
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260

Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
           V+ +G   + QLG    E+   P+ L + +    + V  + G  H+VC+   G  Y  G 
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320

Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
            E G+L L        GE                    GAE+         +  P L+  
Sbjct: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343

Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
           LP  S     +CG+     VT+ G ++ WG G   QLG         P  VE  + KQL+
Sbjct: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397

Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
              V +V+ G  +T +   +K +S
Sbjct: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421


>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 68.6 bits (166), Expect = 9e-12
 Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)

Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
           G V + G G  GQLG G    E + P L+   + +V AE  AGG H+VC+S++G +Y +G
Sbjct: 35  GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92

Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
            N+ G L    R+ + +G  +     EL E   QV                      R  
Sbjct: 93  CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149

Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
               G   P   ++ P    LD+P+    VK + G+ H  ++T  G+LYT G G+ GQLG
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205



 Score = 50.8 bits (120), Expect = 2e-06
 Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)

Query: 16  GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
           G   E   GR   V      P  +     + +VSA  S+TA +T  GR+ L GS      
Sbjct: 92  GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146

Query: 72  RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
             +D     GLL  ++    P +  L V   + A   + L    V+  A+G+    G  +
Sbjct: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200

Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
            G+L  +P   A    R    R L P+            +R +    GA     +   G 
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260

Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
           V+ +G   + QLG    E+   P+ L + +    + V  + G  H+VC+   G  Y  G 
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320

Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
            E G+L L        GE                    GAE+         +  P L+  
Sbjct: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343

Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
           LP  S     +CG+     VT+ G ++ WG G   QLG         P  VE  + KQL+
Sbjct: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397

Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
              V +V+ G  +T +   +K +S
Sbjct: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421


>gi|6912330 deafness locus associated putative guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 458

 Score = 66.6 bits (161), Expect = 3e-11
 Identities = 83/353 (23%), Positives = 131/353 (37%), Gaps = 66/353 (18%)

Query: 15  CGFGQE--LGSGRGRQVHSPSPLRA--GVDICRVSASWSYTAFVTRGGRLELSGSASGAA 70
           CG  ++  LG G    +   +P ++  G  I +V+  W +T  +T  G++   GS S   
Sbjct: 73  CGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNS--- 129

Query: 71  GRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
                          L    GP   +   A E       L  + VV  A G         
Sbjct: 130 ------------FGQLGVPHGPRRCVVPQAIE-------LHKEKVVCIAAGLRHAVAATA 170

Query: 131 AGRL-----PLLPCARAYVSPRA-PFYRPLAPELRARQLE--------LGAEHALLLDAA 176
           +G +      L  C R     +  P +       R   LE         G++H+  L  A
Sbjct: 171 SGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDA 230

Query: 177 GQVFSWGGGRHGQLGHGTLEAELEPRLLEA--LQGLVMAEVAAGGWHSVCVSETGDIYIW 234
           G+V+ WG  +HGQL +      + P+ +EA   Q   +  + +G  H V  +ETG ++ W
Sbjct: 231 GEVYVWGSNKHGQLANEAAFLPV-PQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTW 289

Query: 235 GWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALL 294
           G  + GQL    R L    ET      E  +      R   +   +P             
Sbjct: 290 GRADYGQLG---RKL----ETYEGWKLEKQDSFLPCSRPPNSMPSSPHCL---------- 332

Query: 295 DLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
                + A + SCGS H   +   G  Y+WGW ++G  G     ++  P+ V+
Sbjct: 333 -----TGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQ 379



 Score = 63.5 bits (153), Expect = 3e-10
 Identities = 65/220 (29%), Positives = 96/220 (43%), Gaps = 43/220 (19%)

Query: 161 RQLELGAEHALLLDAAGQVFSWGGGRHGQLG--HGTLEAELEPRLLEALQGLVMAEVAAG 218
           +Q+  G +  ++L   GQV S G    GQLG  HG     + P+ +E  +  V+  +AAG
Sbjct: 104 QQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVV-PQAIELHKEKVVC-IAAG 161

Query: 219 GWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAED 278
             H+V  + +G ++ WG      LA   R L   G+T+                      
Sbjct: 162 LRHAVAATASGIVFQWGTG----LASCGRRLCP-GQTL---------------------- 194

Query: 279 GAPAPFIAVQPFPALLDLPMGSDAVKASC---GSRHTAVVTRTGELYTWGWGKYGQLGHE 335
             P  F A +P         G +  KA C   GS H+A +T  GE+Y WG  K+GQL +E
Sbjct: 195 --PLFFTAKEPSRVT-----GLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANE 247

Query: 336 DTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
               L  P+++E    +  +V A+  G W   V   E GK
Sbjct: 248 -AAFLPVPQKIEAHCFQNEKVTAIWSG-WTHLVAQTETGK 285



 Score = 58.9 bits (141), Expect = 7e-09
 Identities = 85/353 (24%), Positives = 123/353 (34%), Gaps = 93/353 (26%)

Query: 8   AWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDIC------RVSASWSYTAFVTRGGRLE 61
           A F +G   +GQ LG G    V  P  L    D C      R++    ++A VT GG L 
Sbjct: 16  ALFAWGANSYGQ-LGLGHKEDVLLPQQLN---DFCKPRSVRRITGGGGHSAVVTDGGDLF 71

Query: 62  LSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPL------WAQNV 115
           + G         KD           + G G    +  +    +L G P+      W   +
Sbjct: 72  VCGLN-------KDG----------QLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTI 114

Query: 116 VPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQ---LELGAEHALL 172
           +    G+    G    G+L +    R  V P+A        EL   +   +  G  HA+ 
Sbjct: 115 MLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAI-------ELHKEKVVCIAAGLRHAVA 167

Query: 173 LDAAGQVFSWGGGRHGQLGHGTLEAEL--------EPRLLEALQGLVMAEVAAGGWHSVC 224
             A+G VF WG G     G      +         EP  +  L+      V AG  HS  
Sbjct: 168 ATASGIVFQWGTGL-ASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSAS 226

Query: 225 VSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPF 284
           +++ G++Y+WG N+ GQLA                    NE                   
Sbjct: 227 LTDAGEVYVWGSNKHGQLA--------------------NE------------------- 247

Query: 285 IAVQPFPALLDLP--MGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
            A  P P  ++              G  H    T TG+++TWG   YGQLG +
Sbjct: 248 AAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRK 300



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 44/160 (27%), Positives = 69/160 (43%), Gaps = 39/160 (24%)

Query: 175 AAGQVFSWGGGRHGQLGHGTLEAELEPRLL-EALQGLVMAEVAAGGWHSVCVSETGDIYI 233
           AA  +F+WG   +GQLG G  E  L P+ L +  +   +  +  GG HS  V++ GD+++
Sbjct: 13  AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72

Query: 234 WGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPAL 293
            G N+ GQL L                             G  ED    P+    P  +L
Sbjct: 73  CGLNKDGQLGL-----------------------------GHTED---IPYFT--PCKSL 98

Query: 294 LDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
              P+     + +CG   T ++T  G++ + G   +GQLG
Sbjct: 99  FGCPI----QQVACGWDFTIMLTENGQVLSCGSNSFGQLG 134



 Score = 39.7 bits (91), Expect = 0.004
 Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 9/93 (9%)

Query: 137 LPCARAYVSPRAPFYRPLAPELR--ARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT 194
           LPC+R       P   P +P     A ++  G+EH L +   G  +SWG   HG  G GT
Sbjct: 316 LPCSRP------PNSMPSSPHCLTGATEVSCGSEHNLAI-IGGVCYSWGWNEHGMCGDGT 368

Query: 195 LEAELEPRLLEALQGLVMAEVAAGGWHSVCVSE 227
                 P+ ++AL       V  G  HS+ + +
Sbjct: 369 EANVWAPKPVQALLSSSGLLVGCGAGHSLALCQ 401



 Score = 33.9 bits (76), Expect = 0.25
 Identities = 25/72 (34%), Positives = 34/72 (47%), Gaps = 11/72 (15%)

Query: 308 GSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVD-KQL---QVKAVTCGP 363
           G  H+AVVT  G+L+  G  K GQLG      L     + YF   K L    ++ V CG 
Sbjct: 57  GGGHSAVVTDGGDLFVCGLNKDGQLG------LGHTEDIPYFTPCKSLFGCPIQQVACG- 109

Query: 364 WNTYVYAVEKGK 375
           W+  +   E G+
Sbjct: 110 WDFTIMLTENGQ 121


>gi|40316935 alsin isoform 1 [Homo sapiens]
          Length = 1657

 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 39/111 (35%), Positives = 58/111 (52%), Gaps = 8/111 (7%)

Query: 137 LPCARAYVSPRAPFYRPLAPELRARQLEL-----GAEHALLLDAAGQVFSWGGGRHGQLG 191
           LP   + VSPR       A  ++ R + L     G   ALL     +V++WG G+ GQLG
Sbjct: 484 LPGLLSQVSPRL---LRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 540

Query: 192 HGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQL 242
           HG +   L+P  ++ L G  +  + AGG+HS+ ++    +Y WG N  GQL
Sbjct: 541 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQL 591



 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 55/207 (26%), Positives = 90/207 (43%), Gaps = 40/207 (19%)

Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLE-AELEPRLLEALQGLVMAEVAAGGW 220
           Q  LG +H +LL   G+V+S+G         G +E     P L  AL G  +  VA G +
Sbjct: 45  QAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSF 101

Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
           HS  V++ G  Y+WG N +GQ A+  +    +   V+                    D  
Sbjct: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS------------------IADSE 143

Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT-S 339
            +P +AV+              ++ +CG  HT  ++ + E+  W WG   QLG   T   
Sbjct: 144 ASPLLAVR-------------ILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFP 188

Query: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366
           + +P++VE+   +   V  V CG +++
Sbjct: 189 VTKPQKVEHLAGR--VVLQVACGAFHS 213



 Score = 45.1 bits (105), Expect = 1e-04
 Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 1/68 (1%)

Query: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
           LE G  H+L L A  QV+SWG    GQLGH      + PRL +      +  +AAG  +S
Sbjct: 564 LEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV-PRLAKISSENGVWSIAAGRDYS 622

Query: 223 VCVSETGD 230
           + + +T D
Sbjct: 623 LFLVDTED 630



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 3/69 (4%)

Query: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVA 216
           +R  QL  G EH L L  + ++++WG G   QLG  T    + +P+ +E L G V+ +VA
Sbjct: 150 VRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVA 207

Query: 217 AGGWHSVCV 225
            G +HS+ +
Sbjct: 208 CGAFHSLAL 216



 Score = 38.1 bits (87), Expect = 0.013
 Identities = 13/38 (34%), Positives = 21/38 (55%)

Query: 299 GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHED 336
           G + +    G  H+  +T   ++Y+WG   +GQLGH D
Sbjct: 558 GKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD 595



 Score = 32.0 bits (71), Expect = 0.93
 Identities = 15/35 (42%), Positives = 21/35 (60%)

Query: 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL 354
           E++TWG GK GQLGH D     +P  V+    K++
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEV 561


>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
           sapiens]
          Length = 596

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 30/80 (37%), Positives = 49/80 (61%)

Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
           Q+E GA+  L L  +G V++WG G + +LGH +     +P+++E L+G  +  VA G  H
Sbjct: 60  QIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQH 119

Query: 222 SVCVSETGDIYIWGWNESGQ 241
            + V ++G +Y WG N+ GQ
Sbjct: 120 CLAVMDSGQVYAWGDNDHGQ 139



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 40/184 (21%)

Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
           VFSWG G  G+LG G  E    P+ +E L G  + ++  G    + ++++G ++ WG  +
Sbjct: 25  VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84

Query: 239 SGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPM 298
             +L                     +     V++                  P +++   
Sbjct: 85  YFRLG--------------------HRSDVHVRK------------------PQVVEGLR 106

Query: 299 GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKA 358
           G   V  + G++H   V  +G++Y WG   +GQ G+  TT   +P  V+    +  ++  
Sbjct: 107 GKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--KIMC 164

Query: 359 VTCG 362
           V CG
Sbjct: 165 VACG 168



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 25/59 (42%), Positives = 37/59 (62%)

Query: 165 LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSV 223
           +GA+H L +  +GQV++WG   HGQ G+GT     +P L++ L+G  +  VA G  HSV
Sbjct: 115 VGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSV 173


>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1052

 Score = 65.1 bits (157), Expect = 1e-10
 Identities = 30/80 (37%), Positives = 49/80 (61%)

Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
           Q+E GA+  L L  +G V++WG G + +LGH +     +P+++E L+G  +  VA G  H
Sbjct: 712 QIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQH 771

Query: 222 SVCVSETGDIYIWGWNESGQ 241
            + V ++G +Y WG N+ GQ
Sbjct: 772 CLAVMDSGQVYAWGDNDHGQ 791



 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 42/189 (22%), Positives = 77/189 (40%), Gaps = 40/189 (21%)

Query: 174 DAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYI 233
           +  G VFSWG G  G+LG G  E    P+ +E L G  + ++  G    + ++++G ++ 
Sbjct: 672 EMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 731

Query: 234 WGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPAL 293
           WG  +  +L                     +     V++                  P +
Sbjct: 732 WGKGDYFRLG--------------------HRSDVHVRK------------------PQV 753

Query: 294 LDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQ 353
           ++   G   V  + G++H   V  +G++Y WG   +GQ G+  TT   +P  V+    + 
Sbjct: 754 VEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQ- 812

Query: 354 LQVKAVTCG 362
            ++  V CG
Sbjct: 813 -KIMCVACG 820



 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 25/59 (42%), Positives = 37/59 (62%)

Query: 165 LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSV 223
           +GA+H L +  +GQV++WG   HGQ G+GT     +P L++ L+G  +  VA G  HSV
Sbjct: 767 VGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSV 825



 Score = 42.4 bits (98), Expect = 7e-04
 Identities = 42/180 (23%), Positives = 71/180 (39%), Gaps = 30/180 (16%)

Query: 185 GRHGQLGHGTLEAELE-----PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNES 239
           G+HG L   +L +  +     P  +    G ++ + + G W  +   +  D Y       
Sbjct: 613 GKHGDLCEVSLTSSAQGEATWPHPVLFHFGEIIQDKSVGNWEYISTGKVSDNY------- 665

Query: 240 GQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMG 299
              AL T+   E G  V         DG   K   G  +G           P  ++   G
Sbjct: 666 ---ALLTK--CEMGGLVFSWG-----DGDFGKLGRGGSEGCN--------IPQNIERLNG 707

Query: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAV 359
               +  CG++    +T++G ++TWG G Y +LGH     + +P+ VE    K++   AV
Sbjct: 708 QGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAV 767


>gi|126116565 MYC binding protein 2 [Homo sapiens]
          Length = 4640

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 11/123 (8%)

Query: 157  ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
            ELRA Q+  G  H+++L   G V+++G G+HGQLGHG + +   P L++AL G    +V 
Sbjct: 901  ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG-PSTQVT 959

Query: 217  AGGWHSVCVSETGDIYIWGWNESGQLALPTRN----------LAEDGETVAREATELNED 266
            AG  H+  +   G ++ +G    GQL  P  +          +   G    R+AT +   
Sbjct: 960  AGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGAS 1019

Query: 267  GSQ 269
            G Q
Sbjct: 1020 GDQ 1022



 Score = 52.4 bits (124), Expect = 7e-07
 Identities = 24/57 (42%), Positives = 34/57 (59%)

Query: 302 AVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKA 358
           AV+ SCG  H+ V+   G++YT+G+G++GQLGH D  S   P  V+       QV A
Sbjct: 904 AVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA 960



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 33/120 (27%), Positives = 50/120 (41%), Gaps = 39/120 (32%)

Query: 214 EVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRT 273
           +V+ G  HSV + E GD+Y +G+ + GQL          G+  +R               
Sbjct: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLG--------HGDVNSR--------------- 942

Query: 274 GGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
                G P     VQ  P          + + + GS HTAV+   G+++T+G    GQLG
Sbjct: 943 -----GCPT---LVQALPG--------PSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986



 Score = 35.4 bits (80), Expect = 0.084
 Identities = 34/171 (19%), Positives = 62/171 (36%), Gaps = 51/171 (29%)

Query: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAE----LEPRLLEALQGLVMAEVAAGGWHSVC 224
           HALL+   G +F  G    G+ G  T         +P+ +  ++G ++   A     S  
Sbjct: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614

Query: 225 VSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPF 284
           +S+ G++Y++G +                         +  D S +              
Sbjct: 615 ISKDGELYMFGKDA------------------------IYSDSSSL-------------- 636

Query: 285 IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
                   + DL  G    + + G  HT V+ + GE++T+G    GQ G +
Sbjct: 637 --------VTDLK-GHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRD 678



 Score = 33.1 bits (74), Expect = 0.42
 Identities = 19/66 (28%), Positives = 35/66 (53%), Gaps = 2/66 (3%)

Query: 203 LLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGE--TVAREA 260
           L+  L+G  + +VA G  H+  + + G+++ +G N  GQ    T  + + G+   V   A
Sbjct: 636 LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMA 695

Query: 261 TELNED 266
           T ++ED
Sbjct: 696 TAMDED 701


>gi|209364523 alsin isoform 2 [Homo sapiens]
          Length = 396

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 55/207 (26%), Positives = 90/207 (43%), Gaps = 40/207 (19%)

Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLE-AELEPRLLEALQGLVMAEVAAGGW 220
           Q  LG +H +LL   G+V+S+G         G +E     P L  AL G  +  VA G +
Sbjct: 45  QAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSF 101

Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
           HS  V++ G  Y+WG N +GQ A+  +    +   V+                    D  
Sbjct: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS------------------IADSE 143

Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT-S 339
            +P +AV+              ++ +CG  HT  ++ + E+  W WG   QLG   T   
Sbjct: 144 ASPLLAVR-------------ILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFP 188

Query: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366
           + +P++VE+   +   V  V CG +++
Sbjct: 189 VTKPQKVEHLAGR--VVLQVACGAFHS 213



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 3/69 (4%)

Query: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVA 216
           +R  QL  G EH L L  + ++++WG G   QLG  T    + +P+ +E L G V+ +VA
Sbjct: 150 VRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVA 207

Query: 217 AGGWHSVCV 225
            G +HS+ +
Sbjct: 208 CGAFHSLAL 216


>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
           sapiens]
          Length = 464

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 24/212 (11%)

Query: 143 YVSPRAPFYRPL--APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199
           YV   +P   PL    E R  Q+  G  H+L+L     VFS G   +GQ G   +E E+ 
Sbjct: 157 YVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIY 216

Query: 200 -EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED---- 252
            E   +  +Q     + +VA G  HS+ +++ G++Y  GW   GQ  L   N+       
Sbjct: 217 SESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL 276

Query: 253 -----GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP--------FPALLDLPMG 299
                G  V + AT   +    V   GG      + ++ +           P  L     
Sbjct: 277 GGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGV 335

Query: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331
               +A+CG    AV+   G ++ WG+G  G+
Sbjct: 336 GKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367



 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 59/194 (30%), Positives = 79/194 (40%), Gaps = 22/194 (11%)

Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220
           Q+  G +H+L L   G+V+S G G  GQ G G       P  L   L G+ + +VA  G 
Sbjct: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 293

Query: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265
             + VS  G ++ WG +E  QLA  T        R L   G    R+A         LN 
Sbjct: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353

Query: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319
           +G       G     P    +  P    P L  L   +  ++ S   CG  H A +T  G
Sbjct: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413

Query: 320 ELYTWGWGKYGQLG 333
           EL+ WG    G LG
Sbjct: 414 ELFVWGKNIRGCLG 427



 Score = 38.9 bits (89), Expect = 0.008
 Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)

Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339
           V+ +CG  H+  +T  GE+Y+ GWG  GQ  LGH + TS
Sbjct: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271



 Score = 38.5 bits (88), Expect = 0.010
 Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 3/89 (3%)

Query: 289 PFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE--DTTSLDRPRRV 346
           P    LD P  +  ++ SCG  H+ V+T    +++ G   YGQ G +  +        RV
Sbjct: 163 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 222

Query: 347 EYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
               D   QV  V CG  ++ ++  +KG+
Sbjct: 223 HRMQDFDGQVVQVACGQDHS-LFLTDKGE 250



 Score = 34.3 bits (77), Expect = 0.19
 Identities = 16/46 (34%), Positives = 23/46 (50%)

Query: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201
           PE++  ++  G  H   L   G++F WG    G LG G LE +  P
Sbjct: 392 PEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.135    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,281,846
Number of Sequences: 37866
Number of extensions: 805293
Number of successful extensions: 2605
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2136
Number of HSP's gapped (non-prelim): 310
length of query: 376
length of database: 18,247,518
effective HSP length: 104
effective length of query: 272
effective length of database: 14,309,454
effective search space: 3892171488
effective search space used: 3892171488
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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