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Search of human proteins with 63054858
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|63054858 RCC1 domain containing 1 [Homo sapiens]
(376 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 776 0.0
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 776 0.0
gi|126032348 hect domain and RLD 2 [Homo sapiens] 115 6e-26
gi|110825982 hect domain and RLD 5 [Homo sapiens] 114 1e-25
gi|7657152 hect domain and RLD 3 [Homo sapiens] 105 9e-23
gi|61563742 hect domain and RLD 6 [Homo sapiens] 101 1e-21
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 100 3e-21
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 100 3e-21
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 97 2e-20
gi|4557445 regulator of chromosome condensation and BTB domain c... 90 4e-18
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 89 5e-18
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 89 5e-18
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 87 3e-17
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 79 7e-15
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 74 2e-13
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 74 2e-13
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 72 6e-13
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 70 4e-12
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 69 9e-12
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 69 9e-12
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 69 9e-12
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 69 9e-12
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 69 9e-12
gi|6912330 deafness locus associated putative guanine nucleotide... 67 3e-11
gi|40316935 alsin isoform 1 [Homo sapiens] 66 4e-11
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 65 1e-10
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 65 1e-10
gi|126116565 MYC binding protein 2 [Homo sapiens] 65 1e-10
gi|209364523 alsin isoform 2 [Homo sapiens] 64 2e-10
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 62 1e-09
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 776 bits (2003), Expect = 0.0
Identities = 376/376 (100%), Positives = 376/376 (100%)
Query: 1 MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL 60
MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL
Sbjct: 1 MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL 60
Query: 61 ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE 120
ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE
Sbjct: 61 ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE 120
Query: 121 GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF 180
GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF
Sbjct: 121 GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF 180
Query: 181 SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG 240
SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG
Sbjct: 181 SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG 240
Query: 241 QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS 300
QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS
Sbjct: 241 QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS 300
Query: 301 DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360
DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT
Sbjct: 301 DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360
Query: 361 CGPWNTYVYAVEKGKS 376
CGPWNTYVYAVEKGKS
Sbjct: 361 CGPWNTYVYAVEKGKS 376
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 776 bits (2003), Expect = 0.0
Identities = 376/376 (100%), Positives = 376/376 (100%)
Query: 1 MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL 60
MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL
Sbjct: 1 MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSASWSYTAFVTRGGRL 60
Query: 61 ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE 120
ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE
Sbjct: 61 ELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAE 120
Query: 121 GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF 180
GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF
Sbjct: 121 GEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVF 180
Query: 181 SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG 240
SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG
Sbjct: 181 SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESG 240
Query: 241 QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS 300
QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS
Sbjct: 241 QLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGS 300
Query: 301 DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360
DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT
Sbjct: 301 DAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360
Query: 361 CGPWNTYVYAVEKGKS 376
CGPWNTYVYAVEKGKS
Sbjct: 361 CGPWNTYVYAVEKGKS 376
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 115 bits (288), Expect = 6e-26
Identities = 70/213 (32%), Positives = 99/213 (46%), Gaps = 32/213 (15%)
Query: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCV 225
G +H L L + G+V+SWG G+LGHG PR++E+L+G+ + +VAAGG HS CV
Sbjct: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACV 4106
Query: 226 SETGDIYIWGWNESGQLA--------LPTRNLAEDGETVAREATELNE------------ 265
+ GD+Y WG G+L P A G V A +
Sbjct: 4107 TAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTV 4166
Query: 266 ----DGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGEL 321
DG K G DG P +D G VK CGS+ + +T++G +
Sbjct: 4167 WSWGDGDYGKLGRGGSDGCKVPM--------KIDSLTGLGVVKVECGSQFSVALTKSGAV 4218
Query: 322 YTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL 354
YTWG G Y +LGH + RPR+V+ K++
Sbjct: 4219 YTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKV 4251
Score = 102 bits (255), Expect = 4e-22
Identities = 108/396 (27%), Positives = 162/396 (40%), Gaps = 50/396 (12%)
Query: 7 GAWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDICRVSA-SWSYTAF-VTRGGRLELSG 64
G +G+G GQ LG G +V P+P A + V T F VT G+L +G
Sbjct: 3952 GTIYGWGHNHRGQ-LGGIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
Query: 65 SASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDD 124
GA GR L E++ V+ + A+ + +EGE
Sbjct: 4011 Y--GAGGRLGIGGTESVSTPTLL-----ESIQHVFIKKVAVNSGGKHC--LALSSEGEVY 4061
Query: 125 PAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPE----LRARQLELGAEHALLLDAAGQVF 180
GEA+ G+L R+P RP E + + G H+ + AAG ++
Sbjct: 4062 SWGEAEDGKLGH--------GNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLY 4113
Query: 181 SWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGW--HSVCVSETGDIYIWGWNE 238
+WG GR+G+LGH E +L+P+L+EALQG + ++A G ++C+++ ++ WG +
Sbjct: 4114 TWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGD 4173
Query: 239 SGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPF-------- 290
G+L DG V + L G G A AV +
Sbjct: 4174 YGKLGRG----GSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRL 4229
Query: 291 ----------PALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSL 340
P + G + + GS H T GE+YTWG GQLG T ++
Sbjct: 4230 GHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAI 4289
Query: 341 DRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGKS 376
RPR V K +V V CG +T ++ K S
Sbjct: 4290 QRPRLVAALQGK--KVNRVACGSAHTLAWSTSKPAS 4323
Score = 89.4 bits (220), Expect = 5e-18
Identities = 73/270 (27%), Positives = 117/270 (43%), Gaps = 45/270 (16%)
Query: 120 EGEDDPAGEAQAGRLPL------LPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLL 173
EG+ GEA GRL L +P R + + + +A + G HA L
Sbjct: 3010 EGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVA-------VHSGGRHATAL 3062
Query: 174 DAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYI 233
G+VFSWG G G+LGH + +PRL+EAL+ + ++A G HS ++ +G++Y
Sbjct: 3063 TVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYT 3122
Query: 234 WGWNESGQL---------------------ALPTRNLAEDGETVAREATELN---EDGSQ 269
WG E G+L + + D +T+A L DG
Sbjct: 3123 WGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDF 3182
Query: 270 VKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKY 329
K G +G P ++ G + CG++ + +T++G ++TWG G Y
Sbjct: 3183 GKLGRGGSEGC--------NIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDY 3234
Query: 330 GQLGHEDTTSLDRPRRVEYFVDKQLQVKAV 359
+LGH + +P+ VE K++ AV
Sbjct: 3235 FRLGHGSDVHVRKPQVVEGLRGKKIVHVAV 3264
Score = 85.1 bits (209), Expect = 9e-17
Identities = 52/191 (27%), Positives = 87/191 (45%), Gaps = 40/191 (20%)
Query: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGW--HSV 223
G+ ++ + A G++++WG G +G+LGHG+ E E P L+ L+GL + +VA G ++
Sbjct: 559 GSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGDAQTL 618
Query: 224 CVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAP 283
V+E G ++ WG DG K G DG P
Sbjct: 619 AVTENGQVWSWG------------------------------DGDYGKLGRGGSDGCKTP 648
Query: 284 FIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRP 343
L++ D VK CGS+ + +T+ G++Y+WG G +LGH + P
Sbjct: 649 --------KLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYP 700
Query: 344 RRVEYFVDKQL 354
+ +E K++
Sbjct: 701 KLLEGLQGKKV 711
Score = 78.6 bits (192), Expect = 9e-15
Identities = 57/219 (26%), Positives = 96/219 (43%), Gaps = 43/219 (19%)
Query: 147 RAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELE-PRLLE 205
+ P + L Q+ G++ + G+V++ G +G+LG G + PR +
Sbjct: 2981 KVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQIT 3040
Query: 206 ALQGLVMAEVA--AGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATEL 263
AL V+ +VA +GG H+ ++ G ++ WG + G+L + +
Sbjct: 3041 ALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLG---------------HFSRM 3085
Query: 264 NEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYT 323
N D P L++ +CGS H+A +T +GELYT
Sbjct: 3086 NCDK-----------------------PRLIEALKTKRIRDIACGSSHSAALTSSGELYT 3122
Query: 324 WGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
WG G+YG+LGH D T+ +P+ V+ + +V V CG
Sbjct: 3123 WGLGEYGRLGHGDNTTQLKPKMVKVLLGH--RVIQVACG 3159
Score = 77.8 bits (190), Expect = 1e-14
Identities = 57/225 (25%), Positives = 105/225 (46%), Gaps = 28/225 (12%)
Query: 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG 218
R R + G+ H+ L ++G++++WG G +G+LGHG +L+P++++ L G + +VA G
Sbjct: 3100 RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACG 3159
Query: 219 GW--HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDG--------- 267
++ +++ G ++ WG + G+L +G + + LN G
Sbjct: 3160 SRDAQTLALTDEGLVFSWGDGDFGKLGRG----GSEGCNIPQNIERLNGQGVCQIECGAQ 3215
Query: 268 -------SQVKRTGGAEDG---APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTR 317
S V T G D + V+ P +++ G V + G+ H VT
Sbjct: 3216 FSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK-PQVVEGLRGKKIVHVAVGALHCLAVTD 3274
Query: 318 TGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
+G++Y WG +GQ G+ TT +P V+ + ++ V CG
Sbjct: 3275 SGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--KITRVACG 3317
Score = 77.4 bits (189), Expect = 2e-14
Identities = 62/233 (26%), Positives = 102/233 (43%), Gaps = 19/233 (8%)
Query: 15 CGFGQELGSGRGRQVHSPSPL------RAGVDICRVSASWSYTAFVTRGGRLELSGSASG 68
CG G LG G + P + +AG + ++ +Y+A +T G L G G
Sbjct: 521 CGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWG--RG 578
Query: 69 AAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGE 128
GR + + + +L AG ++ V AQ + G+ G+
Sbjct: 579 NYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSGD-------AQTLAVTENGQVWSWGD 631
Query: 129 AQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHG 188
G+L + P +L ++ G++ ++ L GQV+SWG G +
Sbjct: 632 GDYGKLG----RGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQ 687
Query: 189 QLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQ 241
+LGHGT E P+LLE LQG + +VAAG H + ++E +++ WG N+ Q
Sbjct: 688 RLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
Score = 67.4 bits (163), Expect = 2e-11
Identities = 50/175 (28%), Positives = 74/175 (42%), Gaps = 38/175 (21%)
Query: 199 LEPRLLEALQGLVMAEVAA--GGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETV 256
L P+L++ L + ++AA G H + ++ TG++Y WG + G+L G+TV
Sbjct: 482 LAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLG--------HGDTV 533
Query: 257 AREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVT 316
E ++ A G V +CGS ++A +T
Sbjct: 534 PLEEPKV--------------------------ISAFSGKQAGKHVVHIACGSTYSAAIT 567
Query: 317 RTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAV 371
GELYTWG G YG+LGH + P V K L+V V CG + AV
Sbjct: 568 AEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGL--KGLKVIDVACGSGDAQTLAV 620
Score = 55.5 bits (132), Expect = 8e-08
Identities = 25/59 (42%), Positives = 36/59 (61%)
Query: 165 LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSV 223
+GA H L + +GQV++WG HGQ G+GT +P L++ L+G + VA G HSV
Sbjct: 3264 VGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3322
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 114 bits (285), Expect = 1e-25
Identities = 73/226 (32%), Positives = 110/226 (48%), Gaps = 41/226 (18%)
Query: 151 YRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQG 209
+ + E + Q+ G H+L L G++F+WG HGQLG G + P+++E L G
Sbjct: 131 FESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAG 190
Query: 210 LVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQ 269
+ +A+++AG HS+ +S +G+IY WG NE GQL L G T +++ L E
Sbjct: 191 VPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGL--------GHTESKDDPSLIE---- 238
Query: 270 VKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKY 329
D F+A CG H+A++T+ G L+T+G GK+
Sbjct: 239 ------GLDNQKVEFVA--------------------CGGSHSALLTQDGLLFTFGAGKH 272
Query: 330 GQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
GQLGH T + RP V V +V + CG W+T Y + GK
Sbjct: 273 GQLGHNSTQNELRPCLVAELVG--YRVTQIACGRWHTLAYVSDLGK 316
Score = 67.4 bits (163), Expect = 2e-11
Identities = 31/78 (39%), Positives = 49/78 (62%), Gaps = 1/78 (1%)
Query: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVC- 224
G H+ LL G +F++G G+HGQLGH + + EL P L+ L G + ++A G WH++
Sbjct: 251 GGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAY 310
Query: 225 VSETGDIYIWGWNESGQL 242
VS+ G ++ +G + GQL
Sbjct: 311 VSDLGKVFSFGSGKDGQL 328
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 105 bits (261), Expect = 9e-23
Identities = 67/214 (31%), Positives = 96/214 (44%), Gaps = 41/214 (19%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQGLVMAEVAAGGW 220
Q+ G H L L A GQ F+WG HGQLG G ++ P+ + +L+G+ +A+VAAGG
Sbjct: 141 QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGA 200
Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
HS +S +G ++ WG N +GQL L E
Sbjct: 201 HSFALSLSGAVFGWGMNNAGQLGLSDEKDRES---------------------------- 232
Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSL 340
P + L V SCG HTAV+T++G ++T+G G GQLGH+
Sbjct: 233 ----------PCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDE 282
Query: 341 DRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
PRRV + +V + CG +T + G
Sbjct: 283 VNPRRVLELMGS--EVTQIACGRQHTLAFVPSSG 314
Score = 67.8 bits (164), Expect = 2e-11
Identities = 61/234 (26%), Positives = 95/234 (40%), Gaps = 28/234 (11%)
Query: 161 RQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAE-LEPRLLEALQGLVMAEVAAGG 219
+++ G H++ L G+V++ G GQLGH E E +P + AL + VA G
Sbjct: 37 KEVACGGNHSVFLLEDGEVYTCGLNTKGQLGH---EREGNKPEQIGALADQHIIHVACGE 93
Query: 220 WHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG---- 275
HS+ +S+ G ++ WG GQL L T ED V R +LN+ G
Sbjct: 94 SHSLALSDRGQLFSWGAGSDGQLGLMT---TEDSVAVPRLIQKLNQQTILQVSCGNWHCL 150
Query: 276 --AEDG-------------APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGE 320
A DG Q P + G + + G H+ ++ +G
Sbjct: 151 ALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGA 210
Query: 321 LYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
++ WG GQLG D + P V+ + +V ++CG +T V G
Sbjct: 211 VFGWGMNNAGQLGLSDEKDRESPCHVKLL--RTQKVVYISCGEEHTAVLTKSGG 262
Score = 61.2 bits (147), Expect = 1e-09
Identities = 79/339 (23%), Positives = 133/339 (39%), Gaps = 60/339 (17%)
Query: 15 CGFGQELGSGRGRQVHSPSPLRAGVD--ICRVSASWSYTAFVTRGGRLELSGSAS-GAAG 71
CG + G R+ + P + A D I V+ S++ ++ G+L G+ S G G
Sbjct: 58 CGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLG 117
Query: 72 --RCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEA 129
+D+ A L+ L + +LQV W + A+G+ G+
Sbjct: 118 LMTTEDSVAVPRLIQKLNQ----QTILQVSCGN--------W-HCLALAADGQFFTWGKN 164
Query: 130 QAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQ 189
G+L L + + S +P + Q+ G H+ L +G VF WG GQ
Sbjct: 165 SHGQLGL---GKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQ 221
Query: 190 LGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNL 249
LG + P ++ L+ + ++ G H+ ++++G ++ +G GQL + N
Sbjct: 222 LGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMN- 280
Query: 250 AEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGS 309
E R EL MGS+ + +CG
Sbjct: 281 ---DEVNPRRVLEL----------------------------------MGSEVTQIACGR 303
Query: 310 RHT-AVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
+HT A V +G +Y +G G GQLG T ++ P V+
Sbjct: 304 QHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVK 342
Score = 57.8 bits (138), Expect = 2e-08
Identities = 49/194 (25%), Positives = 77/194 (39%), Gaps = 45/194 (23%)
Query: 182 WGGGRHGQLGHGTLEAEL--EPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNES 239
WG GQ G T + EP++ + + EVA GG HSV + E G++Y G N
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 240 GQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMG 299
GQL +G++ ++ G D
Sbjct: 64 GQLG-------------------HEREGNKPEQIGALAD--------------------- 83
Query: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDT-TSLDRPRRVEYFVDKQLQVKA 358
+ +CG H+ ++ G+L++WG G GQLG T S+ PR ++ Q +
Sbjct: 84 QHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKL--NQQTILQ 141
Query: 359 VTCGPWNTYVYAVE 372
V+CG W+ A +
Sbjct: 142 VSCGNWHCLALAAD 155
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 101 bits (251), Expect = 1e-21
Identities = 69/226 (30%), Positives = 103/226 (45%), Gaps = 51/226 (22%)
Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQGLVMAEV 215
+++ Q+ G H+L L QVFSWG HGQLG G ++ P+ + +L+G+ +A+V
Sbjct: 127 DIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQV 186
Query: 216 AAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG 275
AAGG HS +S G + WG N +GQLAL RN+
Sbjct: 187 AAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNV-------------------------- 220
Query: 276 AEDGAPAPFIAVQPFPALLDLPMGSDAVK------ASCGSRHTAVVTRTGELYTWGWGKY 329
P + P+ A+K SCG HTAV+T+ G+++T+G +
Sbjct: 221 ---------------PVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRS 265
Query: 330 GQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
GQLG+ T P+ VE V + CG ++T Y G+
Sbjct: 266 GQLGYSPTPEKRGPQLVERI---DGLVSQIDCGSYHTLAYVHTTGQ 308
Score = 59.7 bits (143), Expect = 4e-09
Identities = 51/194 (26%), Positives = 81/194 (41%), Gaps = 40/194 (20%)
Query: 155 APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGH-GTLEAELEPRLLEALQGLVMA 213
+P Q G H+LLL +V S G GQLG G EL P ++AL+ L++
Sbjct: 20 SPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGEL-PEPIQALETLIVD 78
Query: 214 EVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRT 273
V+ G HS+ V G ++ WG GQL + E E K+
Sbjct: 79 LVSCGKEHSLAVCHKGRVFAWGAGSEGQLGI----------------GEFKEISFTPKK- 121
Query: 274 GGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
L D+ + ++ SCG H+ +++ ++++WG +GQLG
Sbjct: 122 ----------------IMTLNDIKI----IQVSCGHYHSLALSKDSQVFSWGKNSHGQLG 161
Query: 334 -HEDTTSLDRPRRV 346
++ S P+RV
Sbjct: 162 LGKEFPSQASPQRV 175
Score = 46.2 bits (108), Expect = 5e-05
Identities = 25/78 (32%), Positives = 43/78 (55%), Gaps = 2/78 (2%)
Query: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
+ G H +L G+VF++G R GQLG+ + P+L+E + GLV +++ G +H+
Sbjct: 241 ISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLV-SQIDCGSYHT 299
Query: 223 VC-VSETGDIYIWGWNES 239
+ V TG + +G S
Sbjct: 300 LAYVHTTGQVVSFGHGPS 317
Score = 40.8 bits (94), Expect = 0.002
Identities = 39/175 (22%), Positives = 65/175 (37%), Gaps = 41/175 (23%)
Query: 193 GTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED 252
G EL+ R G + + A+G HS+ + + G N GQL
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLG--------- 56
Query: 253 GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHT 312
R G P P A++ ++DL SCG H+
Sbjct: 57 -------------------RRGAQRGELPEPIQALETL--IVDL--------VSCGKEHS 87
Query: 313 AVVTRTGELYTWGWGKYGQLGHEDTTSLD-RPRRVEYFVDKQLQVKAVTCGPWNT 366
V G ++ WG G GQLG + + P+++ D +++ V+CG +++
Sbjct: 88 LAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLND--IKIIQVSCGHYHS 140
Score = 30.4 bits (67), Expect = 2.7
Identities = 23/70 (32%), Positives = 34/70 (48%), Gaps = 5/70 (7%)
Query: 7 GAWFGFGFCGFGQELGSGRGRQVHSPSPLRAG----VDICRVSASWSYTAFVTRGGRLEL 62
G FG+G GQ SGR V S PL G + + +S ++TA +T+ G++
Sbjct: 200 GTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFT 259
Query: 63 SG-SASGAAG 71
G + SG G
Sbjct: 260 FGDNRSGQLG 269
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 100 bits (248), Expect = 3e-21
Identities = 68/220 (30%), Positives = 102/220 (46%), Gaps = 41/220 (18%)
Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQGLVMAEV 215
+++ Q+ G H+L L A +VF WG ++GQLG GT + + P+LL++L G+ +V
Sbjct: 136 DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQV 195
Query: 216 AAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG 275
AAGG HS ++ +G I+ WG N+ GQL LN++ +
Sbjct: 196 AAGGAHSFVLTLSGAIFGWGRNKFGQLG-------------------LNDENDRY----- 231
Query: 276 AEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
P LL V CG HTA +T+ G ++T+G G YGQLGH
Sbjct: 232 --------------VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 336 DTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
T+ PR+V F V + CG +T + G+
Sbjct: 278 STSHEINPRKV--FELMGSIVTEIACGRQHTSAFVPSSGR 315
Score = 67.0 bits (162), Expect = 3e-11
Identities = 58/235 (24%), Positives = 99/235 (42%), Gaps = 26/235 (11%)
Query: 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG 218
R R + G H + + G V++ G GQLGH ++ +P + AL + V+ G
Sbjct: 35 RVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE--KSRKKPEQVVALDAQNIVAVSCG 92
Query: 219 GWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNE------------- 265
H++ +++ G +Y WG + GQL L +E+ V R L++
Sbjct: 93 EAHTLALNDKGQVYAWGLDSDGQLGLVG---SEECIRVPRNIKSLSDIQIVQVACGYYHS 149
Query: 266 ----DGSQVKRTGGAEDG--APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTG 319
S+V G + G Q P LL +G ++ + G H+ V+T +G
Sbjct: 150 LALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSG 209
Query: 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
++ WG K+GQLG D P ++ + ++ + CG +T E G
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL--RSQKIVYICCGEDHTAALTKEGG 262
Score = 63.5 bits (153), Expect = 3e-10
Identities = 50/168 (29%), Positives = 76/168 (45%), Gaps = 17/168 (10%)
Query: 182 WGGGRHGQLGHGTLEAE--LEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNES 239
WG GQLG G ++ E LEPR + + +V G H+V V + G +Y G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 240 GQLA------LPTRNLAEDGETVAR------EATELNEDGSQVKRTGGAEDGAPAPFIAV 287
GQL P + +A D + + LN+ G QV G DG +
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKG-QVYAWGLDSDGQLGLVGSE 122
Query: 288 QPFPALLDLPMGSDA--VKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
+ ++ SD V+ +CG H+ +++ E++ WG KYGQLG
Sbjct: 123 ECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Score = 59.7 bits (143), Expect = 4e-09
Identities = 31/78 (39%), Positives = 44/78 (56%), Gaps = 1/78 (1%)
Query: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH-SVC 224
G +H L G VF++G G +GQLGH + E+ PR + L G ++ E+A G H S
Sbjct: 250 GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAF 309
Query: 225 VSETGDIYIWGWNESGQL 242
V +G IY +G +GQL
Sbjct: 310 VPSSGRIYSFGLGGNGQL 327
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 100 bits (248), Expect = 3e-21
Identities = 68/220 (30%), Positives = 102/220 (46%), Gaps = 41/220 (18%)
Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT-LEAELEPRLLEALQGLVMAEV 215
+++ Q+ G H+L L A +VF WG ++GQLG GT + + P+LL++L G+ +V
Sbjct: 136 DIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQV 195
Query: 216 AAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGG 275
AAGG HS ++ +G I+ WG N+ GQL LN++ +
Sbjct: 196 AAGGAHSFVLTLSGAIFGWGRNKFGQLG-------------------LNDENDRY----- 231
Query: 276 AEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
P LL V CG HTA +T+ G ++T+G G YGQLGH
Sbjct: 232 --------------VPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN 277
Query: 336 DTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
T+ PR+V F V + CG +T + G+
Sbjct: 278 STSHEINPRKV--FELMGSIVTEIACGRQHTSAFVPSSGR 315
Score = 67.0 bits (162), Expect = 3e-11
Identities = 58/235 (24%), Positives = 99/235 (42%), Gaps = 26/235 (11%)
Query: 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG 218
R R + G H + + G V++ G GQLGH ++ +P + AL + V+ G
Sbjct: 35 RVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHE--KSRKKPEQVVALDAQNIVAVSCG 92
Query: 219 GWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNE------------- 265
H++ +++ G +Y WG + GQL L +E+ V R L++
Sbjct: 93 EAHTLALNDKGQVYAWGLDSDGQLGLVG---SEECIRVPRNIKSLSDIQIVQVACGYYHS 149
Query: 266 ----DGSQVKRTGGAEDG--APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTG 319
S+V G + G Q P LL +G ++ + G H+ V+T +G
Sbjct: 150 LALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSG 209
Query: 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
++ WG K+GQLG D P ++ + ++ + CG +T E G
Sbjct: 210 AIFGWGRNKFGQLGLNDENDRYVPNLLKSL--RSQKIVYICCGEDHTAALTKEGG 262
Score = 63.5 bits (153), Expect = 3e-10
Identities = 50/168 (29%), Positives = 76/168 (45%), Gaps = 17/168 (10%)
Query: 182 WGGGRHGQLGHGTLEAE--LEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNES 239
WG GQLG G ++ E LEPR + + +V G H+V V + G +Y G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 240 GQLA------LPTRNLAEDGETVAR------EATELNEDGSQVKRTGGAEDGAPAPFIAV 287
GQL P + +A D + + LN+ G QV G DG +
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQNIVAVSCGEAHTLALNDKG-QVYAWGLDSDGQLGLVGSE 122
Query: 288 QPFPALLDLPMGSDA--VKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
+ ++ SD V+ +CG H+ +++ E++ WG KYGQLG
Sbjct: 123 ECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLG 170
Score = 59.7 bits (143), Expect = 4e-09
Identities = 31/78 (39%), Positives = 44/78 (56%), Gaps = 1/78 (1%)
Query: 166 GAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH-SVC 224
G +H L G VF++G G +GQLGH + E+ PR + L G ++ E+A G H S
Sbjct: 250 GEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAF 309
Query: 225 VSETGDIYIWGWNESGQL 242
V +G IY +G +GQL
Sbjct: 310 VPSSGRIYSFGLGGNGQL 327
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 97.1 bits (240), Expect = 2e-20
Identities = 62/193 (32%), Positives = 100/193 (51%), Gaps = 15/193 (7%)
Query: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGWHSVCVSE 227
H L G+VFSWG G +G+LGHG + P+L++ LQG V+ V+AG HS V+E
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTE 528
Query: 228 TGDIYIWGWNESGQLA--------LPT--RNLAEDGETV--AREATELNEDGSQVKRTGG 275
G++Y WG + G+L +PT ++++ GE + L++DG V GG
Sbjct: 529 DGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFGG 588
Query: 276 AEDGAPAPFIAVQPF-PALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH 334
++G + + P +++ G K GS+ + +T TG++Y WG G G
Sbjct: 589 GDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGS 648
Query: 335 EDTTSLDRPRRVE 347
+ T+L RP+ +E
Sbjct: 649 SEATAL-RPKLIE 660
Score = 90.9 bits (224), Expect = 2e-18
Identities = 57/193 (29%), Positives = 97/193 (50%), Gaps = 15/193 (7%)
Query: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSET 228
H++ L +G+VFSWG G +G+LGHG + + PR +EALQG + +++ G HS V+
Sbjct: 4093 HSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSD 4152
Query: 229 GDIYIWGWNESGQLA--------LPTRNLAEDGETVAREATELNE------DGSQVKRTG 274
G ++ +G + G+L LP R A +G + + A LN DGS V G
Sbjct: 4153 GKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
Query: 275 GAEDG-APAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
+ G + P +D+ G K +CG++ + +T+ G +YT+G + L
Sbjct: 4213 DGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLP 4272
Query: 334 HEDTTSLDRPRRV 346
+ +RP+++
Sbjct: 4273 EGRARNHNRPQQI 4285
Score = 80.5 bits (197), Expect = 2e-15
Identities = 65/237 (27%), Positives = 105/237 (44%), Gaps = 56/237 (23%)
Query: 129 AQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHG 188
A+AGR ++P A AP + +A+Q+ G ++ A G V + G G +G
Sbjct: 4011 AEAGRNVMVPAA-------APSFS------QAQQVICGQNCTFVIQANGTVLACGEGSYG 4057
Query: 189 QLGHGTLEAELEPRLLEALQGLVMAEV---AAGGWHSVCVSETGDIYIWGWNESGQLALP 245
+LG G + ++ ALQG V+ ++ HS+ ++E+G+++ WG
Sbjct: 4058 RLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWG---------- 4107
Query: 246 TRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKA 305
DG K G D Q P ++ G + V+
Sbjct: 4108 --------------------DGDYGKLGHGNSDR--------QRRPRQIEALQGEEVVQM 4139
Query: 306 SCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
SCG +H+AVVT G+L+T+G G YG+LG +T++ P RV + Q+ V CG
Sbjct: 4140 SCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTAL--EGYQIGQVACG 4194
Score = 76.3 bits (186), Expect = 4e-14
Identities = 62/207 (29%), Positives = 89/207 (42%), Gaps = 24/207 (11%)
Query: 178 QVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWN 237
+V+ WG QL GT E L+P+L + E AG + + +S G + G
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTIE--AGQYCTFVISTDGSVRACGKG 430
Query: 238 ESGQLALPTRN--------LAEDGETVAREATELNEDGSQVKRTGGAE-----DGAPAPF 284
G+L L N E ++ + ++ DG + T E DG
Sbjct: 431 SYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKL 490
Query: 285 ----IAVQPFPALLDLPM-GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTS 339
+ Q +P L+ P+ G V S G RH+A VT GELYTWG G +G+LGH D+ S
Sbjct: 491 GHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNS 550
Query: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366
R + V V V+CG +T
Sbjct: 551 ----RNIPTLVKDISNVGEVSCGSSHT 573
Score = 73.9 bits (180), Expect = 2e-13
Identities = 49/187 (26%), Positives = 82/187 (43%), Gaps = 41/187 (21%)
Query: 162 QLELGAEHALLLDAAGQ-VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGW 220
++ G+ H + L G+ V+S+GGG +G+LGHG +P+++EALQG+ + +V AG
Sbjct: 565 EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQ 624
Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
S+ ++ TG +Y WG + EAT L
Sbjct: 625 SSLALTSTGQVYAWGCGACLGCG-------------SSEATALR---------------- 655
Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTS- 339
P L++ + V S G H ++ E+Y WG GQ G ++T
Sbjct: 656 ----------PKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGP 705
Query: 340 LDRPRRV 346
+ +P++V
Sbjct: 706 ITKPKKV 712
Score = 67.4 bits (163), Expect = 2e-11
Identities = 55/220 (25%), Positives = 94/220 (42%), Gaps = 24/220 (10%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
Q+ G +H+ ++ + G++F++G G +G+LG G + P + AL+G + +VA G H
Sbjct: 4138 QMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNH 4197
Query: 222 SVCVSETGD-IYIWGWNESGQLALPTRNLAEDGETV--------------AREATELNED 266
++ VS G ++ +G + G+L L + + + + L +D
Sbjct: 4198 TLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKD 4257
Query: 267 GSQV----KRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELY 322
G R G +G Q P L + + AV G+ HT + G++Y
Sbjct: 4258 GHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAV----GAEHTLALASNGDVY 4313
Query: 323 TWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL-QVKAVTC 361
WG GQLG T + P V K + Q+ A C
Sbjct: 4314 AWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRC 4353
Score = 60.5 bits (145), Expect = 2e-09
Identities = 65/253 (25%), Positives = 109/253 (43%), Gaps = 23/253 (9%)
Query: 1 MAEERPGAWFGFGFCGFGQELGSGRGRQVHSPSPLRA--GVDICRVSASWSYTAFVTRGG 58
MA G F +G +G+ LG G + P + A G ++ ++S + ++A VT G
Sbjct: 4095 MALTESGEVFSWGDGDYGK-LGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDG 4153
Query: 59 RLELSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQN--VV 116
+L G+ G GR S L PE +V A E G+ N +
Sbjct: 4154 KLFTFGN--GDYGRLGLGNTSNKKL--------PE---RVTALEGYQIGQVACGLNHTLA 4200
Query: 117 PEAEGEDDPA-GEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDA 175
A+G A G+ G+L L + +P + + +++ G + ++ L
Sbjct: 4201 VSADGSMVWAFGDGDYGKLGL----GNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTK 4256
Query: 176 AGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
G V+++G R L G P+ + L G+++ +VA G H++ ++ GD+Y WG
Sbjct: 4257 DGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWG 4316
Query: 236 WNESGQLALPTRN 248
N GQL L N
Sbjct: 4317 SNSEGQLGLGHTN 4329
Score = 57.4 bits (137), Expect = 2e-08
Identities = 63/245 (25%), Positives = 100/245 (40%), Gaps = 35/245 (14%)
Query: 7 GAWFGFGFCGFGQELGSGRGRQVHSPS----PLRAGVDICRVSASWSYTAFVTRGGRLEL 62
G F +G +G+ LG G P PL+ V +C VSA + ++A VT G L
Sbjct: 477 GEVFSWGDGDYGK-LGHGNSSTQKYPKLIQGPLQGKVVVC-VSAGYRHSAAVTEDGELYT 534
Query: 63 SGSAS-GAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEG 121
G G G + L + G + + G +W+ G
Sbjct: 535 WGEGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSKDGRTVWSFG-----GG 589
Query: 122 EDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPE----LRARQLELGAEHALLLDAAG 177
++ G R+ Y+P E + R++ G++ +L L + G
Sbjct: 590 DNGKLGHGDTNRV----------------YKPKVIEALQGMFIRKVCAGSQSSLALTSTG 633
Query: 178 QVFSWGGGRHGQLGHGTLEAE-LEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGW 236
QV++WG G LG G+ EA L P+L+E L + +V+ G H + +S ++Y WG
Sbjct: 634 QVYAWGCG--ACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGN 691
Query: 237 NESGQ 241
N GQ
Sbjct: 692 NSMGQ 696
Score = 53.1 bits (126), Expect = 4e-07
Identities = 34/90 (37%), Positives = 46/90 (51%), Gaps = 1/90 (1%)
Query: 133 RLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGH 192
RL LP RA R P P+ + + +GAEH L L + G V++WG GQLG
Sbjct: 4267 RLIGLPEGRARNHNR-PQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGL 4325
Query: 193 GTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
G EP L+ LQG + +++AG HS
Sbjct: 4326 GHTNHVREPTLVTGLQGKNVRQISAGRCHS 4355
Score = 42.7 bits (99), Expect = 5e-04
Identities = 26/84 (30%), Positives = 42/84 (50%), Gaps = 5/84 (5%)
Query: 145 SPRAPFYRP-LAPELRARQL---ELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199
S A RP L EL A ++ +G H L L +V++WG GQ G G +
Sbjct: 648 SSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPIT 707
Query: 200 EPRLLEALQGLVMAEVAAGGWHSV 223
+P+ + L G+ + +++AG HS+
Sbjct: 708 KPKKVSGLDGIAIQQISAGTSHSL 731
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 89.7 bits (221), Expect = 4e-18
Identities = 55/198 (27%), Positives = 90/198 (45%), Gaps = 39/198 (19%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHG-TLEAELEPRLLEALQGLVMAEVAAGGW 220
++ G+ H+L+L + G+VF+WG GQ+G G T+ + R+ LQ V+ +A G
Sbjct: 156 EVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQM 215
Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
+ V +TG++Y+WG+N +GQL L G+
Sbjct: 216 CCMAVVDTGEVYVWGYNGNGQLG-------------------LGNSGN------------ 244
Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSL 340
QP P + G + +CG HT V+T G++Y WG YGQLG + ++
Sbjct: 245 -------QPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQ 297
Query: 341 DRPRRVEYFVDKQLQVKA 358
P V D+ +++ A
Sbjct: 298 SYPTPVTVEKDRIIEIAA 315
Score = 78.2 bits (191), Expect = 1e-14
Identities = 58/206 (28%), Positives = 86/206 (41%), Gaps = 42/206 (20%)
Query: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP-RLLEALQGLVMAEVAAGGWHSVCVSE 227
H +L G+VF+WG + QLG+GT L P + L + EVA G +HS+ ++
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
Query: 228 TGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAV 287
G+++ WG+N SGQ+ GS V
Sbjct: 170 DGEVFAWGYNNSGQVG----------------------SGSTVN---------------- 191
Query: 288 QPFPA-LLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRV 346
QP P + V +CG V TGE+Y WG+ GQLG ++ + P RV
Sbjct: 192 QPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRV 251
Query: 347 EYFVDKQLQVKAVTCGPWNTYVYAVE 372
+ ++V+ V CG +T V E
Sbjct: 252 AAL--QGIRVQRVACGYAHTLVLTDE 275
Score = 67.4 bits (163), Expect = 2e-11
Identities = 49/186 (26%), Positives = 80/186 (43%), Gaps = 39/186 (20%)
Query: 178 QVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAG-GWHSVCVSETGDIYIWGW 236
++F G G LG G +++ +EPR L++L G +A ++ G G H V + G+++ WG
Sbjct: 66 EIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGH 125
Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDL 296
N QL T N G +T L+
Sbjct: 126 NAYSQLGNGTTN---HGLVPCHISTNLSN------------------------------- 151
Query: 297 PMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQV 356
++ +CGS H+ V+T GE++ WG+ GQ+G T + PRRV + ++ V
Sbjct: 152 ---KQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKV-V 207
Query: 357 KAVTCG 362
+ CG
Sbjct: 208 VTIACG 213
Score = 48.5 bits (114), Expect = 1e-05
Identities = 25/89 (28%), Positives = 43/89 (48%), Gaps = 1/89 (1%)
Query: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAA 217
+R +++ G H L+L GQV++WG +GQLG G + P + + ++ A
Sbjct: 257 IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAAC 316
Query: 218 GGWH-SVCVSETGDIYIWGWNESGQLALP 245
H S ++ G +Y+WG + LP
Sbjct: 317 HSTHTSAAKTQGGHVYMWGQCRGQSVILP 345
Score = 37.4 bits (85), Expect = 0.022
Identities = 26/79 (32%), Positives = 36/79 (45%), Gaps = 2/79 (2%)
Query: 291 PALLDLPMGSDAVKASCGSR-HTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYF 349
P LD G S GS H + T GE++TWG Y QLG+ T P +
Sbjct: 89 PRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTN 148
Query: 350 VDKQLQVKAVTCGPWNTYV 368
+ + QV V CG +++ V
Sbjct: 149 LSNK-QVIEVACGSYHSLV 166
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 89.4 bits (220), Expect = 5e-18
Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 60/229 (26%)
Query: 167 AEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVS 226
A H+LL+ G+++SWG GQLGHG + PRL+E L V+ A G H++ ++
Sbjct: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218
Query: 227 ETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIA 286
ETG ++ +G N+ GQL L G D P+P
Sbjct: 219 ETGSVFAFGENKMGQLGL-----------------------------GNQTDAVPSPAQI 249
Query: 287 VQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH-EDTTSLDRPRR 345
+ G K +CG+ + ++ G LY++G +YGQLGH D + R +R
Sbjct: 250 MY---------NGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
Query: 346 VEY-----------FVDK----------QLQVKAVTCGPWNTYVYAVEK 373
+EY F++K + V+ V CG +T V +K
Sbjct: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQK 349
Score = 63.9 bits (154), Expect = 2e-10
Identities = 32/82 (39%), Positives = 48/82 (58%), Gaps = 2/82 (2%)
Query: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQ--GLVMA 213
P + R + GA H L+LD+ +VFSWG G +G+LGH + E+ PRL++ G +
Sbjct: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387
Query: 214 EVAAGGWHSVCVSETGDIYIWG 235
++ AG S VSE G ++ WG
Sbjct: 388 QIYAGYTCSFAVSEVGGLFFWG 409
Score = 44.7 bits (104), Expect = 1e-04
Identities = 19/45 (42%), Positives = 30/45 (66%), Gaps = 1/45 (2%)
Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
V SC + H+ ++T G+L++WG + GQLGH DT ++ PR +E
Sbjct: 154 VSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197
Score = 43.9 bits (102), Expect = 2e-04
Identities = 35/142 (24%), Positives = 63/142 (44%), Gaps = 32/142 (22%)
Query: 127 GEAQAGRLPLLPCARAYVSPRAPFY--RPLAPELRARQLELGAEHALLLDAAGQVFSWGG 184
GE + G+L L A SP Y +P+ ++ GAE ++++D G ++S+G
Sbjct: 227 GENKMGQLGLGNQTDAVPSPAQIMYNGQPIT------KMACGAEFSMIMDCKGNLYSFGC 280
Query: 185 GRHGQLGHGT------------LEAELEPRLLE------------ALQGLVMAEVAAGGW 220
+GQLGH + + EL PR + + +V+ +VA G
Sbjct: 281 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 340
Query: 221 HSVCVSETGDIYIWGWNESGQL 242
H++ + ++ WG+ G+L
Sbjct: 341 HTLVLDSQKRVFSWGFGGYGRL 362
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 89.4 bits (220), Expect = 5e-18
Identities = 64/229 (27%), Positives = 99/229 (43%), Gaps = 60/229 (26%)
Query: 167 AEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVS 226
A H+LL+ G+++SWG GQLGHG + PRL+E L V+ A G H++ ++
Sbjct: 159 AAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALT 218
Query: 227 ETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIA 286
ETG ++ +G N+ GQL L G D P+P
Sbjct: 219 ETGSVFAFGENKMGQLGL-----------------------------GNQTDAVPSPAQI 249
Query: 287 VQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH-EDTTSLDRPRR 345
+ G K +CG+ + ++ G LY++G +YGQLGH D + R +R
Sbjct: 250 MY---------NGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQR 300
Query: 346 VEY-----------FVDK----------QLQVKAVTCGPWNTYVYAVEK 373
+EY F++K + V+ V CG +T V +K
Sbjct: 301 IEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQK 349
Score = 63.9 bits (154), Expect = 2e-10
Identities = 32/82 (39%), Positives = 48/82 (58%), Gaps = 2/82 (2%)
Query: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQ--GLVMA 213
P + R + GA H L+LD+ +VFSWG G +G+LGH + E+ PRL++ G +
Sbjct: 328 PNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGAS 387
Query: 214 EVAAGGWHSVCVSETGDIYIWG 235
++ AG S VSE G ++ WG
Sbjct: 388 QIYAGYTCSFAVSEVGGLFFWG 409
Score = 44.7 bits (104), Expect = 1e-04
Identities = 19/45 (42%), Positives = 30/45 (66%), Gaps = 1/45 (2%)
Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
V SC + H+ ++T G+L++WG + GQLGH DT ++ PR +E
Sbjct: 154 VSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197
Score = 43.9 bits (102), Expect = 2e-04
Identities = 35/142 (24%), Positives = 63/142 (44%), Gaps = 32/142 (22%)
Query: 127 GEAQAGRLPLLPCARAYVSPRAPFY--RPLAPELRARQLELGAEHALLLDAAGQVFSWGG 184
GE + G+L L A SP Y +P+ ++ GAE ++++D G ++S+G
Sbjct: 227 GENKMGQLGLGNQTDAVPSPAQIMYNGQPIT------KMACGAEFSMIMDCKGNLYSFGC 280
Query: 185 GRHGQLGHGT------------LEAELEPRLLE------------ALQGLVMAEVAAGGW 220
+GQLGH + + EL PR + + +V+ +VA G
Sbjct: 281 PEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPNVVVRDVACGAN 340
Query: 221 HSVCVSETGDIYIWGWNESGQL 242
H++ + ++ WG+ G+L
Sbjct: 341 HTLVLDSQKRVFSWGFGGYGRL 362
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 86.7 bits (213), Expect = 3e-17
Identities = 60/214 (28%), Positives = 101/214 (47%), Gaps = 43/214 (20%)
Query: 160 ARQLELGAEHALLLDAAGQVFSW----GGGR-HGQLGHGTLEAELEPRLLEALQGLVMAE 214
ARQ+ G H ++ ++++W GG + HGQLGHG + +P+ +E LQG + +
Sbjct: 371 ARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGKAIRQ 430
Query: 215 VAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTG 274
V+ G +VCV++ G +Y +G + G + V +
Sbjct: 431 VSCGDDFTVCVTDEGQLYAFGSDYYGCMG--------------------------VDKVA 464
Query: 275 GAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGH 334
G E ++P L+ + + + SCG H V+TR E+Y+WG G+YG+LG
Sbjct: 465 GPE--------VLEPMQ--LNFFLSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGL 514
Query: 335 EDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYV 368
+ P++V+ V K L + AV CG T++
Sbjct: 515 DSEEDYYTPQKVD--VPKALIIVAVQCGCDGTFL 546
Score = 50.1 bits (118), Expect = 3e-06
Identities = 43/172 (25%), Positives = 71/172 (41%), Gaps = 25/172 (14%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
Q+ G H ++L +V+SWG G +G+LG + E P+ ++ + L++ V G
Sbjct: 484 QVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDG 543
Query: 222 SVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAP 281
+ ++++G + G NE +L L N G + EA +V T
Sbjct: 544 TFLLTQSGKVLACGLNEFNKLGL---NQCMSG-IINHEAYH------EVPYTTSFTLAKQ 593
Query: 282 APFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
F ++ + G HTA + G L T+G K GQLG
Sbjct: 594 LSFYKIRTI---------------APGKTHTAAIDERGRLLTFGCNKCGQLG 630
Score = 47.8 bits (112), Expect = 2e-05
Identities = 30/78 (38%), Positives = 39/78 (50%), Gaps = 14/78 (17%)
Query: 297 PMGSDAVKASCGSR-------HTAVVTRTGELYTW-----GWGKYGQLGHEDTTSLDRPR 344
P D +K+ C +R H AVVT ELYTW G +GQLGH D S +P+
Sbjct: 359 PQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPK 418
Query: 345 RVEYFVDKQLQVKAVTCG 362
VE K ++ V+CG
Sbjct: 419 HVEKLQGK--AIRQVSCG 434
Score = 42.0 bits (97), Expect = 0.001
Identities = 24/87 (27%), Positives = 43/87 (49%), Gaps = 1/87 (1%)
Query: 159 RARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAA 217
+ R + G H +D G++ ++G + GQLG G + L LL L G + V+
Sbjct: 598 KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSC 657
Query: 218 GGWHSVCVSETGDIYIWGWNESGQLAL 244
G ++ ++ I+ WG +G+LA+
Sbjct: 658 GDEFTIAATDDNHIFAWGNGGNGRLAM 684
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 79.0 bits (193), Expect = 7e-15
Identities = 80/312 (25%), Positives = 123/312 (39%), Gaps = 56/312 (17%)
Query: 109 PLWAQNVVPEAEGEDDPAGEAQAGRL-----PLLPCARAYVSPRAPFYRPLAPELRARQL 163
P+ VV A G AG ++GRL P L + P A P+ +R L
Sbjct: 328 PMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGA--VEQPQPQFISRFL 385
Query: 164 E-----------LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVM 212
E G L G + ++G G +G LGHG+L +P ++EAL G M
Sbjct: 386 EGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEM 445
Query: 213 AEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRN------------------------ 248
+VA G H + +S +++ WG +SG+L L TR
Sbjct: 446 VQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGID 505
Query: 249 ----LAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQ---PFPALLDLPMGSD 301
L G+ +A + N+ G G P P V+ F L P+ +
Sbjct: 506 SSMILTVPGQALACGSNRFNKLGLDHLSLG----EEPVPHQQVEEALSFTLLGSAPLDQE 561
Query: 302 -AVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVT 360
+ G+ H+A VT +G+ YT+G ++GQLG P +V+ + +++ V
Sbjct: 562 PLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGL--EGIKMAMVA 619
Query: 361 CGPWNTYVYAVE 372
CG T E
Sbjct: 620 CGDAFTVAIGAE 631
Score = 62.8 bits (151), Expect = 5e-10
Identities = 91/372 (24%), Positives = 134/372 (36%), Gaps = 80/372 (21%)
Query: 21 LGSGRGR----QVHSPSPL--------RAGVDICRVSASWSYTAFVTRGGRLELSGSASG 68
LG+G G V P P ++GV I V+ +TA +T G + GS S
Sbjct: 361 LGAGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSN 420
Query: 69 AAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGE 128
G L + EALL + A + A + E E G
Sbjct: 421 GC-------LGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALST----ERELFAWGR 469
Query: 129 AQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHG 188
+GRL L S P P+ P A+++ G + +++L GQ + G R
Sbjct: 470 GDSGRLGL----GTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFN 525
Query: 189 QLGHGTLEAELEP----RLLEALQGLVMA----------EVAAGGWHSVCVSETGDIYIW 234
+LG L EP ++ EAL ++ + G HS V+ +GD Y +
Sbjct: 526 KLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTF 585
Query: 235 GWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALL 294
G N+ GQL TR GS+ AP ++
Sbjct: 586 GSNQHGQLGTNTRR------------------GSR----------APCKVQGLE------ 611
Query: 295 DLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL 354
G +CG T + E+Y+WG G G+LG D + PR V+
Sbjct: 612 ----GIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDA-GLPRPVQLDETHPY 666
Query: 355 QVKAVTCGPWNT 366
V +V+C NT
Sbjct: 667 TVTSVSCCHGNT 678
Score = 44.7 bits (104), Expect = 1e-04
Identities = 44/157 (28%), Positives = 61/157 (38%), Gaps = 22/157 (14%)
Query: 231 IYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTG----------GAEDGA 280
+Y WG L LP N E V A + G V R+G GA G+
Sbjct: 314 VYAWGGGLGTPLRLPMLNT----EVVQVAAGRTQKAG--VTRSGRLILWEAPPLGAGGGS 367
Query: 281 PAPFIAVQPFPAL----LDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHED 336
P QP P L+ G +CG TA +T G + T+G G G LGH
Sbjct: 368 LLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGS 427
Query: 337 TTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEK 373
T + +P VE + ++ V CG + + E+
Sbjct: 428 LTDISQPTIVEALLG--YEMVQVACGASHVLALSTER 462
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 74.3 bits (181), Expect = 2e-13
Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 21/231 (9%)
Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
E + +QL G+ + L G++F WG GQ+G + P+ + G ++ ++
Sbjct: 139 EHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWIS 196
Query: 217 AGGWHSVCVSETGDIYIWGWNESGQLALPTRNL---------AEDGETVAREA------T 261
G +HS V+ G++Y++G E+G+L LP + L +E E V + A
Sbjct: 197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV 256
Query: 262 ELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGEL 321
L E+ G F+ P +++ SCG HTA++T G +
Sbjct: 257 VLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316
Query: 322 YTWGWGKYGQ--LGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYA 370
YT+G G++G+ LG E+ T+ P F+ + VK V CG + V+A
Sbjct: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFL--RFIVKLVACGGCHMVVFA 365
Score = 63.5 bits (153), Expect = 3e-10
Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 22/223 (9%)
Query: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
L G EH+ ++ +++ +G GQLG G+ A +P ++AL+ + A G H+
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
Query: 223 VCVSETGDIYIWGWNESGQLAL---------------PTRNLAEDGETVAREATELNEDG 267
+ +E G++Y G N GQL L + + + + + L EDG
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159
Query: 268 SQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWG 327
+E ++ P + +G SCG H+A VT GELY +G
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEP 217
Query: 328 KYGQLG--HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYV 368
+ G+LG ++ + P+ V +K +Q V CG +T V
Sbjct: 218 ENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTVV 257
Score = 60.1 bits (144), Expect = 3e-09
Identities = 56/232 (24%), Positives = 101/232 (43%), Gaps = 23/232 (9%)
Query: 152 RPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQG-L 210
+ L PE + + G H L+ G V++ GG GQLG G E ++
Sbjct: 82 KALKPE-KVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEH 140
Query: 211 VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALP--TRNLAEDGETVAREATELN---- 264
+ +++AG S ++E G +++WG N GQ+ L + T+ + + ++
Sbjct: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYY 200
Query: 265 ------EDGSQVKRTGGAED---GAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVV 315
DG ++ G E+ G P + P L+ + ++ +CG HT V+
Sbjct: 201 HSAFVTTDG-ELYVFGEPENGKLGLPNQLLGNHRTPQLVS-EIPEKVIQVACGGEHTVVL 258
Query: 316 TRTGELYTWGWGKYGQLG-HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNT 366
T +YT+G G++GQLG P+ +E D+ + ++CG +T
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQ--TISYISCGENHT 307
Score = 49.3 bits (116), Expect = 6e-06
Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 5/130 (3%)
Query: 120 EGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQV 179
+GE GE + G+L L + + R P PE + Q+ G EH ++L V
Sbjct: 208 DGELYVFGEPENGKLGLPN--QLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVL-TENAV 263
Query: 180 FSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
+++G G+ GQLG GT E EP+++E ++ ++ ++ G H+ +++ G +Y +G
Sbjct: 264 YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGR 323
Query: 239 SGQLALPTRN 248
G+L L N
Sbjct: 324 HGKLGLGLEN 333
Score = 44.7 bits (104), Expect = 1e-04
Identities = 25/66 (37%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
V SCG H+AVVT +LY +G +GQLG +++ +P V+ K +VK CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKAL--KPEKVKLAACG 95
Query: 363 PWNTYV 368
+T V
Sbjct: 96 RNHTLV 101
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 50/204 (24%)
Query: 172 LLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDI 231
L+ +G VF++G + + G + + V ++ G HS V+ +
Sbjct: 7 LMPDSGAVFTFGKSKFAENNPGKFWFKND----------VPVHLSCGDEHSAVVTGNNKL 56
Query: 232 YIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFP 291
Y++G N GQL L +++ P A++P
Sbjct: 57 YMFGSNNWGQLGLGSKSAISK----------------------------PTCVKALKPEK 88
Query: 292 ALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVD 351
L A+CG HT V T G +Y G GQLG DT + + +F
Sbjct: 89 VKL----------AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTS 138
Query: 352 KQLQVKAVTCGPWNTYVYAVEKGK 375
+ ++K ++ G NT E G+
Sbjct: 139 EH-KIKQLSAGS-NTSAALTEDGR 160
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 74.3 bits (181), Expect = 2e-13
Identities = 62/231 (26%), Positives = 105/231 (45%), Gaps = 21/231 (9%)
Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
E + +QL G+ + L G++F WG GQ+G + P+ + G ++ ++
Sbjct: 139 EHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWIS 196
Query: 217 AGGWHSVCVSETGDIYIWGWNESGQLALPTRNL---------AEDGETVAREA------T 261
G +HS V+ G++Y++G E+G+L LP + L +E E V + A
Sbjct: 197 CGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV 256
Query: 262 ELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGEL 321
L E+ G F+ P +++ SCG HTA++T G +
Sbjct: 257 VLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLM 316
Query: 322 YTWGWGKYGQ--LGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYA 370
YT+G G++G+ LG E+ T+ P F+ + VK V CG + V+A
Sbjct: 317 YTFGDGRHGKLGLGLENFTNHFIPTLCSNFL--RFIVKLVACGGCHMVVFA 365
Score = 63.5 bits (153), Expect = 3e-10
Identities = 57/223 (25%), Positives = 96/223 (43%), Gaps = 22/223 (9%)
Query: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
L G EH+ ++ +++ +G GQLG G+ A +P ++AL+ + A G H+
Sbjct: 40 LSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHT 99
Query: 223 VCVSETGDIYIWGWNESGQLAL---------------PTRNLAEDGETVAREATELNEDG 267
+ +E G++Y G N GQL L + + + + + L EDG
Sbjct: 100 LVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDG 159
Query: 268 SQVKRTGGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWG 327
+E ++ P + +G SCG H+A VT GELY +G
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVCVPQ--QVTIGKPVSWISCGYYHSAFVTTDGELYVFGEP 217
Query: 328 KYGQLG--HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYV 368
+ G+LG ++ + P+ V +K +Q V CG +T V
Sbjct: 218 ENGKLGLPNQLLGNHRTPQLVSEIPEKVIQ---VACGGEHTVV 257
Score = 60.1 bits (144), Expect = 3e-09
Identities = 56/232 (24%), Positives = 101/232 (43%), Gaps = 23/232 (9%)
Query: 152 RPLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQG-L 210
+ L PE + + G H L+ G V++ GG GQLG G E ++
Sbjct: 82 KALKPE-KVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEH 140
Query: 211 VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALP--TRNLAEDGETVAREATELN---- 264
+ +++AG S ++E G +++WG N GQ+ L + T+ + + ++
Sbjct: 141 KIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYY 200
Query: 265 ------EDGSQVKRTGGAED---GAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVV 315
DG ++ G E+ G P + P L+ + ++ +CG HT V+
Sbjct: 201 HSAFVTTDG-ELYVFGEPENGKLGLPNQLLGNHRTPQLVS-EIPEKVIQVACGGEHTVVL 258
Query: 316 TRTGELYTWGWGKYGQLG-HEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNT 366
T +YT+G G++GQLG P+ +E D+ + ++CG +T
Sbjct: 259 TENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQ--TISYISCGENHT 307
Score = 49.3 bits (116), Expect = 6e-06
Identities = 38/130 (29%), Positives = 67/130 (51%), Gaps = 5/130 (3%)
Query: 120 EGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQLELGAEHALLLDAAGQV 179
+GE GE + G+L L + + R P PE + Q+ G EH ++L V
Sbjct: 208 DGELYVFGEPENGKLGLPN--QLLGNHRTPQLVSEIPE-KVIQVACGGEHTVVL-TENAV 263
Query: 180 FSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
+++G G+ GQLG GT E EP+++E ++ ++ ++ G H+ +++ G +Y +G
Sbjct: 264 YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGR 323
Query: 239 SGQLALPTRN 248
G+L L N
Sbjct: 324 HGKLGLGLEN 333
Score = 44.7 bits (104), Expect = 1e-04
Identities = 25/66 (37%), Positives = 36/66 (54%), Gaps = 2/66 (3%)
Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCG 362
V SCG H+AVVT +LY +G +GQLG +++ +P V+ K +VK CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKAL--KPEKVKLAACG 95
Query: 363 PWNTYV 368
+T V
Sbjct: 96 RNHTLV 101
Score = 41.6 bits (96), Expect = 0.001
Identities = 45/204 (22%), Positives = 75/204 (36%), Gaps = 50/204 (24%)
Query: 172 LLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDI 231
L+ +G VF++G + + G + + V ++ G HS V+ +
Sbjct: 7 LMPDSGAVFTFGKSKFAENNPGKFWFKND----------VPVHLSCGDEHSAVVTGNNKL 56
Query: 232 YIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFP 291
Y++G N GQL L +++ P A++P
Sbjct: 57 YMFGSNNWGQLGLGSKSAISK----------------------------PTCVKALKPEK 88
Query: 292 ALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVD 351
L A+CG HT V T G +Y G GQLG DT + + +F
Sbjct: 89 VKL----------AACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTS 138
Query: 352 KQLQVKAVTCGPWNTYVYAVEKGK 375
+ ++K ++ G NT E G+
Sbjct: 139 EH-KIKQLSAGS-NTSAALTEDGR 160
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 72.4 bits (176), Expect = 6e-13
Identities = 57/230 (24%), Positives = 93/230 (40%), Gaps = 34/230 (14%)
Query: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP-RLLEALQGLVMAEVAAGGWHSVCVSE 227
H LL G V++WG + QLG+GT + P ++ L + EVA G HS+ ++
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145
Query: 228 TGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAV 287
G+++ WG+N GQ+ G T + + +KR G G + +
Sbjct: 146 DGEVFAWGYNNCGQVG--------SGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVL 197
Query: 288 Q-------PFPALLDLPMGSDAVKAS----------------CGSRHTAVVTRTGELYTW 324
+ L +G++ + + CG HT +T G LY W
Sbjct: 198 DNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAW 257
Query: 325 GWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKG 374
G YGQLG + +L P + V+K+ V+ C +T + G
Sbjct: 258 GANTYGQLGTGNKNNLLSPAHI--MVEKERVVEIAACHSAHTSAAKTQGG 305
Score = 43.1 bits (100), Expect = 4e-04
Identities = 25/85 (29%), Positives = 38/85 (44%), Gaps = 1/85 (1%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
Q+ G H L L G +++WG +GQLG G L P + + V+ A H
Sbjct: 237 QIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAH 296
Query: 222 -SVCVSETGDIYIWGWNESGQLALP 245
S ++ G +Y+WG + LP
Sbjct: 297 TSAAKTQGGHVYMWGQCRGQSVILP 321
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 69.7 bits (169), Expect = 4e-12
Identities = 67/223 (30%), Positives = 96/223 (43%), Gaps = 43/223 (19%)
Query: 141 RAYVSPRAPFYR-------PLAPELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHG 193
RA S R P R P P+ + R + H G V + G G GQLG G
Sbjct: 27 RAAASRRVPGARSCQGACGPSPPDQKTRPVS----HRSHSTEPGLVLTLGQGDVGQLGLG 82
Query: 194 TLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED 252
E + P L+ + +V AE AGG H+VC+S++G +Y +G N+ G L R+ + +
Sbjct: 83 ENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFGCNDEGALG---RDTSVE 137
Query: 253 GETVAREATELNEDGSQVK---------------------RTGGAEDGAPAPF-IAVQPF 290
G + EL E QV R G P ++ P
Sbjct: 138 GSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPV 197
Query: 291 PALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 198 QVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 236
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 123 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 177
Query: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 178 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 231
Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
G+L +P A R R L P+ +R + GA + G
Sbjct: 232 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 291
Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 292 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 351
Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
E G+L L GE GAE+ + P L+
Sbjct: 352 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 374
Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 375 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 428
Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
V +V+ G +T + +K +S
Sbjct: 429 NRVVLSVSSGGQHTVLLVKDKEQS 452
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 68.6 bits (166), Expect = 9e-12
Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)
Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
G V + G G GQLG G E + P L+ + +V AE AGG H+VC+S++G +Y +G
Sbjct: 52 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 109
Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
N+ G L R+ + +G + EL E QV R
Sbjct: 110 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 166
Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
G P ++ P LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 167 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 222
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 109 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 163
Query: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 164 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 217
Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
G+L +P A R R L P+ +R + GA + G
Sbjct: 218 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 277
Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 278 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 337
Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
E G+L L GE GAE+ + P L+
Sbjct: 338 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 360
Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 361 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 414
Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
V +V+ G +T + +K +S
Sbjct: 415 NRVVLSVSSGGQHTVLLVKDKEQS 438
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 68.6 bits (166), Expect = 9e-12
Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)
Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
G V + G G GQLG G E + P L+ + +V AE AGG H+VC+S++G +Y +G
Sbjct: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92
Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
N+ G L R+ + +G + EL E QV R
Sbjct: 93 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
G P ++ P LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 92 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146
Query: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200
Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
G+L +P A R R L P+ +R + GA + G
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260
Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
E G+L L GE GAE+ + P L+
Sbjct: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343
Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397
Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
V +V+ G +T + +K +S
Sbjct: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 68.6 bits (166), Expect = 9e-12
Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)
Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
G V + G G GQLG G E + P L+ + +V AE AGG H+VC+S++G +Y +G
Sbjct: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92
Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
N+ G L R+ + +G + EL E QV R
Sbjct: 93 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
G P ++ P LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 92 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146
Query: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200
Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
G+L +P A R R L P+ +R + GA + G
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260
Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
E G+L L GE GAE+ + P L+
Sbjct: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343
Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397
Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
V +V+ G +T + +K +S
Sbjct: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 68.6 bits (166), Expect = 9e-12
Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)
Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
G V + G G GQLG G E + P L+ + +V AE AGG H+VC+S++G +Y +G
Sbjct: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92
Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
N+ G L R+ + +G + EL E QV R
Sbjct: 93 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
G P ++ P LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 92 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146
Query: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200
Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
G+L +P A R R L P+ +R + GA + G
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260
Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
E G+L L GE GAE+ + P L+
Sbjct: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343
Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397
Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
V +V+ G +T + +K +S
Sbjct: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 68.6 bits (166), Expect = 9e-12
Identities = 57/180 (31%), Positives = 83/180 (46%), Gaps = 32/180 (17%)
Query: 177 GQVFSWGGGRHGQLGHGTLEAELE-PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWG 235
G V + G G GQLG G E + P L+ + +V AE AGG H+VC+S++G +Y +G
Sbjct: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAE--AGGMHTVCLSKSGQVYSFG 92
Query: 236 WNESGQLALPTRNLAEDGETVAREATELNEDGSQVK---------------------RTG 274
N+ G L R+ + +G + EL E QV R
Sbjct: 93 CNDEGALG---RDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDN 149
Query: 275 GAEDGAPAPF-IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
G P ++ P LD+P+ VK + G+ H ++T G+LYT G G+ GQLG
Sbjct: 150 NGVIGLLEPMKKSMVPVQVQLDVPV----VKVASGNDHLVMLTADGDLYTLGCGEQGQLG 205
Score = 50.8 bits (120), Expect = 2e-06
Identities = 96/384 (25%), Positives = 146/384 (38%), Gaps = 77/384 (20%)
Query: 16 GFGQELGSGRGRQVHS----PSPLRAGVDICRVSASWSYTAFVTRGGRLELSGSASGAAG 71
G E GR V P + + +VSA S+TA +T GR+ L GS
Sbjct: 92 GCNDEGALGRDTSVEGSEMVPGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSF----- 146
Query: 72 RCKDAWASEGLLAVLRAGPGP-EALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
+D GLL ++ P + L V + A + L V+ A+G+ G +
Sbjct: 147 --RDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHL----VMLTADGDLYTLGCGE 200
Query: 131 AGRLPLLPCARAYVSPRAPFYRPLAPE------------LRARQLELGAEHALLLDAAGQ 178
G+L +P A R R L P+ +R + GA + G
Sbjct: 201 QGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGH 260
Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEV--AAGGWHSVCVSETGDIYIWGW 236
V+ +G + QLG E+ P+ L + + + V + G H+VC+ G Y G
Sbjct: 261 VYGFGLSNYHQLGTPGTESCFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGR 320
Query: 237 NESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLD- 295
E G+L L GE GAE+ + P L+
Sbjct: 321 AEYGRLGL--------GE--------------------GAEE---------KSIPTLISR 343
Query: 296 LPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQ 355
LP S +CG+ VT+ G ++ WG G QLG P VE + KQL+
Sbjct: 344 LPAVS---SVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP--VE-MMGKQLE 397
Query: 356 ---VKAVTCGPWNTYVYAVEKGKS 376
V +V+ G +T + +K +S
Sbjct: 398 NRVVLSVSSGGQHTVLLVKDKEQS 421
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 66.6 bits (161), Expect = 3e-11
Identities = 83/353 (23%), Positives = 131/353 (37%), Gaps = 66/353 (18%)
Query: 15 CGFGQE--LGSGRGRQVHSPSPLRA--GVDICRVSASWSYTAFVTRGGRLELSGSASGAA 70
CG ++ LG G + +P ++ G I +V+ W +T +T G++ GS S
Sbjct: 73 CGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQVLSCGSNS--- 129
Query: 71 GRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPLWAQNVVPEAEGEDDPAGEAQ 130
L GP + A E L + VV A G
Sbjct: 130 ------------FGQLGVPHGPRRCVVPQAIE-------LHKEKVVCIAAGLRHAVAATA 170
Query: 131 AGRL-----PLLPCARAYVSPRA-PFYRPLAPELRARQLE--------LGAEHALLLDAA 176
+G + L C R + P + R LE G++H+ L A
Sbjct: 171 SGIVFQWGTGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDA 230
Query: 177 GQVFSWGGGRHGQLGHGTLEAELEPRLLEA--LQGLVMAEVAAGGWHSVCVSETGDIYIW 234
G+V+ WG +HGQL + + P+ +EA Q + + +G H V +ETG ++ W
Sbjct: 231 GEVYVWGSNKHGQLANEAAFLPV-PQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTW 289
Query: 235 GWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALL 294
G + GQL R L ET E + R + +P
Sbjct: 290 GRADYGQLG---RKL----ETYEGWKLEKQDSFLPCSRPPNSMPSSPHCL---------- 332
Query: 295 DLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVE 347
+ A + SCGS H + G Y+WGW ++G G ++ P+ V+
Sbjct: 333 -----TGATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQ 379
Score = 63.5 bits (153), Expect = 3e-10
Identities = 65/220 (29%), Positives = 96/220 (43%), Gaps = 43/220 (19%)
Query: 161 RQLELGAEHALLLDAAGQVFSWGGGRHGQLG--HGTLEAELEPRLLEALQGLVMAEVAAG 218
+Q+ G + ++L GQV S G GQLG HG + P+ +E + V+ +AAG
Sbjct: 104 QQVACGWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVV-PQAIELHKEKVVC-IAAG 161
Query: 219 GWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAED 278
H+V + +G ++ WG LA R L G+T+
Sbjct: 162 LRHAVAATASGIVFQWGTG----LASCGRRLCP-GQTL---------------------- 194
Query: 279 GAPAPFIAVQPFPALLDLPMGSDAVKASC---GSRHTAVVTRTGELYTWGWGKYGQLGHE 335
P F A +P G + KA C GS H+A +T GE+Y WG K+GQL +E
Sbjct: 195 --PLFFTAKEPSRVT-----GLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANE 247
Query: 336 DTTSLDRPRRVEYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
L P+++E + +V A+ G W V E GK
Sbjct: 248 -AAFLPVPQKIEAHCFQNEKVTAIWSG-WTHLVAQTETGK 285
Score = 58.9 bits (141), Expect = 7e-09
Identities = 85/353 (24%), Positives = 123/353 (34%), Gaps = 93/353 (26%)
Query: 8 AWFGFGFCGFGQELGSGRGRQVHSPSPLRAGVDIC------RVSASWSYTAFVTRGGRLE 61
A F +G +GQ LG G V P L D C R++ ++A VT GG L
Sbjct: 16 ALFAWGANSYGQ-LGLGHKEDVLLPQQLN---DFCKPRSVRRITGGGGHSAVVTDGGDLF 71
Query: 62 LSGSASGAAGRCKDAWASEGLLAVLRAGPGPEALLQVWAAESALRGEPL------WAQNV 115
+ G KD + G G + + +L G P+ W +
Sbjct: 72 VCGLN-------KDG----------QLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTI 114
Query: 116 VPEAEGEDDPAGEAQAGRLPLLPCARAYVSPRAPFYRPLAPELRARQ---LELGAEHALL 172
+ G+ G G+L + R V P+A EL + + G HA+
Sbjct: 115 MLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAI-------ELHKEKVVCIAAGLRHAVA 167
Query: 173 LDAAGQVFSWGGGRHGQLGHGTLEAEL--------EPRLLEALQGLVMAEVAAGGWHSVC 224
A+G VF WG G G + EP + L+ V AG HS
Sbjct: 168 ATASGIVFQWGTGL-ASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSAS 226
Query: 225 VSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPF 284
+++ G++Y+WG N+ GQLA NE
Sbjct: 227 LTDAGEVYVWGSNKHGQLA--------------------NE------------------- 247
Query: 285 IAVQPFPALLDLP--MGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
A P P ++ G H T TG+++TWG YGQLG +
Sbjct: 248 AAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRK 300
Score = 56.6 bits (135), Expect = 4e-08
Identities = 44/160 (27%), Positives = 69/160 (43%), Gaps = 39/160 (24%)
Query: 175 AAGQVFSWGGGRHGQLGHGTLEAELEPRLL-EALQGLVMAEVAAGGWHSVCVSETGDIYI 233
AA +F+WG +GQLG G E L P+ L + + + + GG HS V++ GD+++
Sbjct: 13 AAAALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFV 72
Query: 234 WGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPAL 293
G N+ GQL L G ED P+ P +L
Sbjct: 73 CGLNKDGQLGL-----------------------------GHTED---IPYFT--PCKSL 98
Query: 294 LDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
P+ + +CG T ++T G++ + G +GQLG
Sbjct: 99 FGCPI----QQVACGWDFTIMLTENGQVLSCGSNSFGQLG 134
Score = 39.7 bits (91), Expect = 0.004
Identities = 28/93 (30%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 137 LPCARAYVSPRAPFYRPLAPELR--ARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGT 194
LPC+R P P +P A ++ G+EH L + G +SWG HG G GT
Sbjct: 316 LPCSRP------PNSMPSSPHCLTGATEVSCGSEHNLAI-IGGVCYSWGWNEHGMCGDGT 368
Query: 195 LEAELEPRLLEALQGLVMAEVAAGGWHSVCVSE 227
P+ ++AL V G HS+ + +
Sbjct: 369 EANVWAPKPVQALLSSSGLLVGCGAGHSLALCQ 401
Score = 33.9 bits (76), Expect = 0.25
Identities = 25/72 (34%), Positives = 34/72 (47%), Gaps = 11/72 (15%)
Query: 308 GSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVD-KQL---QVKAVTCGP 363
G H+AVVT G+L+ G K GQLG L + YF K L ++ V CG
Sbjct: 57 GGGHSAVVTDGGDLFVCGLNKDGQLG------LGHTEDIPYFTPCKSLFGCPIQQVACG- 109
Query: 364 WNTYVYAVEKGK 375
W+ + E G+
Sbjct: 110 WDFTIMLTENGQ 121
>gi|40316935 alsin isoform 1 [Homo sapiens]
Length = 1657
Score = 66.2 bits (160), Expect = 4e-11
Identities = 39/111 (35%), Positives = 58/111 (52%), Gaps = 8/111 (7%)
Query: 137 LPCARAYVSPRAPFYRPLAPELRARQLEL-----GAEHALLLDAAGQVFSWGGGRHGQLG 191
LP + VSPR A ++ R + L G ALL +V++WG G+ GQLG
Sbjct: 484 LPGLLSQVSPRL---LRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 540
Query: 192 HGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQL 242
HG + L+P ++ L G + + AGG+HS+ ++ +Y WG N GQL
Sbjct: 541 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQL 591
Score = 64.3 bits (155), Expect = 2e-10
Identities = 55/207 (26%), Positives = 90/207 (43%), Gaps = 40/207 (19%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLE-AELEPRLLEALQGLVMAEVAAGGW 220
Q LG +H +LL G+V+S+G G +E P L AL G + VA G +
Sbjct: 45 QAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSF 101
Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
HS V++ G Y+WG N +GQ A+ + + V+ D
Sbjct: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS------------------IADSE 143
Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT-S 339
+P +AV+ ++ +CG HT ++ + E+ W WG QLG T
Sbjct: 144 ASPLLAVR-------------ILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFP 188
Query: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366
+ +P++VE+ + V V CG +++
Sbjct: 189 VTKPQKVEHLAGR--VVLQVACGAFHS 213
Score = 45.1 bits (105), Expect = 1e-04
Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
LE G H+L L A QV+SWG GQLGH + PRL + + +AAG +S
Sbjct: 564 LEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV-PRLAKISSENGVWSIAAGRDYS 622
Query: 223 VCVSETGD 230
+ + +T D
Sbjct: 623 LFLVDTED 630
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVA 216
+R QL G EH L L + ++++WG G QLG T + +P+ +E L G V+ +VA
Sbjct: 150 VRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVA 207
Query: 217 AGGWHSVCV 225
G +HS+ +
Sbjct: 208 CGAFHSLAL 216
Score = 38.1 bits (87), Expect = 0.013
Identities = 13/38 (34%), Positives = 21/38 (55%)
Query: 299 GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHED 336
G + + G H+ +T ++Y+WG +GQLGH D
Sbjct: 558 GKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD 595
Score = 32.0 bits (71), Expect = 0.93
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL 354
E++TWG GK GQLGH D +P V+ K++
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEV 561
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 65.1 bits (157), Expect = 1e-10
Identities = 30/80 (37%), Positives = 49/80 (61%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
Q+E GA+ L L +G V++WG G + +LGH + +P+++E L+G + VA G H
Sbjct: 60 QIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQH 119
Query: 222 SVCVSETGDIYIWGWNESGQ 241
+ V ++G +Y WG N+ GQ
Sbjct: 120 CLAVMDSGQVYAWGDNDHGQ 139
Score = 54.7 bits (130), Expect = 1e-07
Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 40/184 (21%)
Query: 179 VFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNE 238
VFSWG G G+LG G E P+ +E L G + ++ G + ++++G ++ WG +
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
Query: 239 SGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPM 298
+L + V++ P +++
Sbjct: 85 YFRLG--------------------HRSDVHVRK------------------PQVVEGLR 106
Query: 299 GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKA 358
G V + G++H V +G++Y WG +GQ G+ TT +P V+ + ++
Sbjct: 107 GKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--KIMC 164
Query: 359 VTCG 362
V CG
Sbjct: 165 VACG 168
Score = 54.7 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 37/59 (62%)
Query: 165 LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSV 223
+GA+H L + +GQV++WG HGQ G+GT +P L++ L+G + VA G HSV
Sbjct: 115 VGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSV 173
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 65.1 bits (157), Expect = 1e-10
Identities = 30/80 (37%), Positives = 49/80 (61%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWH 221
Q+E GA+ L L +G V++WG G + +LGH + +P+++E L+G + VA G H
Sbjct: 712 QIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQH 771
Query: 222 SVCVSETGDIYIWGWNESGQ 241
+ V ++G +Y WG N+ GQ
Sbjct: 772 CLAVMDSGQVYAWGDNDHGQ 791
Score = 56.6 bits (135), Expect = 4e-08
Identities = 42/189 (22%), Positives = 77/189 (40%), Gaps = 40/189 (21%)
Query: 174 DAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYI 233
+ G VFSWG G G+LG G E P+ +E L G + ++ G + ++++G ++
Sbjct: 672 EMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 731
Query: 234 WGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPAL 293
WG + +L + V++ P +
Sbjct: 732 WGKGDYFRLG--------------------HRSDVHVRK------------------PQV 753
Query: 294 LDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQ 353
++ G V + G++H V +G++Y WG +GQ G+ TT +P V+ +
Sbjct: 754 VEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQ- 812
Query: 354 LQVKAVTCG 362
++ V CG
Sbjct: 813 -KIMCVACG 820
Score = 54.7 bits (130), Expect = 1e-07
Identities = 25/59 (42%), Positives = 37/59 (62%)
Query: 165 LGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHSV 223
+GA+H L + +GQV++WG HGQ G+GT +P L++ L+G + VA G HSV
Sbjct: 767 VGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSV 825
Score = 42.4 bits (98), Expect = 7e-04
Identities = 42/180 (23%), Positives = 71/180 (39%), Gaps = 30/180 (16%)
Query: 185 GRHGQLGHGTLEAELE-----PRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNES 239
G+HG L +L + + P + G ++ + + G W + + D Y
Sbjct: 613 GKHGDLCEVSLTSSAQGEATWPHPVLFHFGEIIQDKSVGNWEYISTGKVSDNY------- 665
Query: 240 GQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQPFPALLDLPMG 299
AL T+ E G V DG K G +G P ++ G
Sbjct: 666 ---ALLTK--CEMGGLVFSWG-----DGDFGKLGRGGSEGCN--------IPQNIERLNG 707
Query: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKAV 359
+ CG++ +T++G ++TWG G Y +LGH + +P+ VE K++ AV
Sbjct: 708 QGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAV 767
>gi|126116565 MYC binding protein 2 [Homo sapiens]
Length = 4640
Score = 64.7 bits (156), Expect = 1e-10
Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 11/123 (8%)
Query: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
ELRA Q+ G H+++L G V+++G G+HGQLGHG + + P L++AL G +V
Sbjct: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG-PSTQVT 959
Query: 217 AGGWHSVCVSETGDIYIWGWNESGQLALPTRN----------LAEDGETVAREATELNED 266
AG H+ + G ++ +G GQL P + + G R+AT +
Sbjct: 960 AGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGAS 1019
Query: 267 GSQ 269
G Q
Sbjct: 1020 GDQ 1022
Score = 52.4 bits (124), Expect = 7e-07
Identities = 24/57 (42%), Positives = 34/57 (59%)
Query: 302 AVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKA 358
AV+ SCG H+ V+ G++YT+G+G++GQLGH D S P V+ QV A
Sbjct: 904 AVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA 960
Score = 41.6 bits (96), Expect = 0.001
Identities = 33/120 (27%), Positives = 50/120 (41%), Gaps = 39/120 (32%)
Query: 214 EVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRT 273
+V+ G HSV + E GD+Y +G+ + GQL G+ +R
Sbjct: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLG--------HGDVNSR--------------- 942
Query: 274 GGAEDGAPAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLG 333
G P VQ P + + + GS HTAV+ G+++T+G GQLG
Sbjct: 943 -----GCPT---LVQALPG--------PSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
Score = 35.4 bits (80), Expect = 0.084
Identities = 34/171 (19%), Positives = 62/171 (36%), Gaps = 51/171 (29%)
Query: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAE----LEPRLLEALQGLVMAEVAAGGWHSVC 224
HALL+ G +F G G+ G T +P+ + ++G ++ A S
Sbjct: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614
Query: 225 VSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPF 284
+S+ G++Y++G + + D S +
Sbjct: 615 ISKDGELYMFGKDA------------------------IYSDSSSL-------------- 636
Query: 285 IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
+ DL G + + G HT V+ + GE++T+G GQ G +
Sbjct: 637 --------VTDLK-GHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRD 678
Score = 33.1 bits (74), Expect = 0.42
Identities = 19/66 (28%), Positives = 35/66 (53%), Gaps = 2/66 (3%)
Query: 203 LLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGE--TVAREA 260
L+ L+G + +VA G H+ + + G+++ +G N GQ T + + G+ V A
Sbjct: 636 LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMA 695
Query: 261 TELNED 266
T ++ED
Sbjct: 696 TAMDED 701
>gi|209364523 alsin isoform 2 [Homo sapiens]
Length = 396
Score = 64.3 bits (155), Expect = 2e-10
Identities = 55/207 (26%), Positives = 90/207 (43%), Gaps = 40/207 (19%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLE-AELEPRLLEALQGLVMAEVAAGGW 220
Q LG +H +LL G+V+S+G G +E P L AL G + VA G +
Sbjct: 45 QAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSF 101
Query: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
HS V++ G Y+WG N +GQ A+ + + V+ D
Sbjct: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS------------------IADSE 143
Query: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT-S 339
+P +AV+ ++ +CG HT ++ + E+ W WG QLG T
Sbjct: 144 ASPLLAVR-------------ILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFP 188
Query: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366
+ +P++VE+ + V V CG +++
Sbjct: 189 VTKPQKVEHLAGR--VVLQVACGAFHS 213
Score = 41.2 bits (95), Expect = 0.002
Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVA 216
+R QL G EH L L + ++++WG G QLG T + +P+ +E L G V+ +VA
Sbjct: 150 VRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVA 207
Query: 217 AGGWHSVCV 225
G +HS+ +
Sbjct: 208 CGAFHSLAL 216
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 61.6 bits (148), Expect = 1e-09
Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 24/212 (11%)
Query: 143 YVSPRAPFYRPL--APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199
YV +P PL E R Q+ G H+L+L VFS G +GQ G +E E+
Sbjct: 157 YVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIY 216
Query: 200 -EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED---- 252
E + +Q + +VA G HS+ +++ G++Y GW GQ L N+
Sbjct: 217 SESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL 276
Query: 253 -----GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP--------FPALLDLPMG 299
G V + AT + V GG + ++ + P L
Sbjct: 277 GGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGV 335
Query: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331
+A+CG AV+ G ++ WG+G G+
Sbjct: 336 GKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
Score = 57.0 bits (136), Expect = 3e-08
Identities = 59/194 (30%), Positives = 79/194 (40%), Gaps = 22/194 (11%)
Query: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220
Q+ G +H+L L G+V+S G G GQ G G P L L G+ + +VA G
Sbjct: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 293
Query: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265
+ VS G ++ WG +E QLA T R L G R+A LN
Sbjct: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
Query: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319
+G G P + P P L L + ++ S CG H A +T G
Sbjct: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413
Query: 320 ELYTWGWGKYGQLG 333
EL+ WG G LG
Sbjct: 414 ELFVWGKNIRGCLG 427
Score = 38.9 bits (89), Expect = 0.008
Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339
V+ +CG H+ +T GE+Y+ GWG GQ LGH + TS
Sbjct: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271
Score = 38.5 bits (88), Expect = 0.010
Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 289 PFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE--DTTSLDRPRRV 346
P LD P + ++ SCG H+ V+T +++ G YGQ G + + RV
Sbjct: 163 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 222
Query: 347 EYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
D QV V CG ++ ++ +KG+
Sbjct: 223 HRMQDFDGQVVQVACGQDHS-LFLTDKGE 250
Score = 34.3 bits (77), Expect = 0.19
Identities = 16/46 (34%), Positives = 23/46 (50%)
Query: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201
PE++ ++ G H L G++F WG G LG G LE + P
Sbjct: 392 PEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.135 0.426
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,281,846
Number of Sequences: 37866
Number of extensions: 805293
Number of successful extensions: 2605
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 42
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2136
Number of HSP's gapped (non-prelim): 310
length of query: 376
length of database: 18,247,518
effective HSP length: 104
effective length of query: 272
effective length of database: 14,309,454
effective search space: 3892171488
effective search space used: 3892171488
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.