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Search of human proteins with 62750349
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
(1123 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens] 2234 0.0
gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens] 2228 0.0
gi|153085395 histone deacetylase 4 [Homo sapiens] 1204 0.0
gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens] 1173 0.0
gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens] 1165 0.0
gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens] 1123 0.0
gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens] 894 0.0
gi|169234807 histone deacetylase 7 isoform a [Homo sapiens] 721 0.0
gi|148539870 histone deacetylase 7 isoform d [Homo sapiens] 697 0.0
gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens] 498 e-140
gi|13128864 histone deacetylase 6 [Homo sapiens] 286 8e-77
gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens] 235 2e-61
gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens] 204 5e-52
gi|116284376 histone deacetylase 2 [Homo sapiens] 106 1e-22
gi|13128860 histone deacetylase 1 [Homo sapiens] 105 2e-22
gi|8923769 histone deacetylase 8 [Homo sapiens] 96 2e-19
gi|13128862 histone deacetylase 3 [Homo sapiens] 89 2e-17
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 71 5e-12
gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens] 69 2e-11
gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo sap... 67 1e-10
gi|221139761 zinc finger protein 853 [Homo sapiens] 66 2e-10
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 65 4e-10
gi|17017963 forkhead box P2 isoform I [Homo sapiens] 64 8e-10
gi|22538413 forkhead box P2 isoform III [Homo sapiens] 64 8e-10
gi|149999352 forkhead box P2 isoform II [Homo sapiens] 64 8e-10
gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens] 64 8e-10
gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens] 64 1e-09
gi|56549694 enabled homolog isoform a [Homo sapiens] 63 2e-09
gi|39930375 enabled homolog isoform b [Homo sapiens] 63 2e-09
gi|33286444 mastermind-like 2 [Homo sapiens] 63 2e-09
>gi|62750349 histone deacetylase 5 isoform 3 [Homo sapiens]
Length = 1123
Score = 2234 bits (5789), Expect = 0.0
Identities = 1123/1123 (100%), Positives = 1123/1123 (100%)
Query: 1 MNSPNESADGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVEL 60
MNSPNESADGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVEL
Sbjct: 1 MNSPNESADGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVEL 60
Query: 61 RGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQ 120
RGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQ
Sbjct: 61 RGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQ 120
Query: 121 QQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIA 180
QQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIA
Sbjct: 121 QQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIA 180
Query: 181 STEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYK 240
STEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYK
Sbjct: 181 STEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYK 240
Query: 241 LPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVE 300
LPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVE
Sbjct: 241 LPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVE 300
Query: 301 ITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPN 360
ITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPN
Sbjct: 301 ITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPN 360
Query: 361 QFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMS 420
QFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMS
Sbjct: 361 QFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMS 420
Query: 421 TSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVAT 480
TSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVAT
Sbjct: 421 TSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVAT 480
Query: 481 SMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTG 540
SMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTG
Sbjct: 481 SMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTG 540
Query: 541 ELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEE 600
ELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEE
Sbjct: 541 ELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEE 600
Query: 601 DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRT 660
DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRT
Sbjct: 601 DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRT 660
Query: 661 QSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQ 720
QSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQ
Sbjct: 661 QSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQ 720
Query: 721 ETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVL 780
ETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVL
Sbjct: 721 ETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVL 780
Query: 781 PCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTA 840
PCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTA
Sbjct: 781 PCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTA 840
Query: 841 MGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGN 900
MGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGN
Sbjct: 841 MGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGN 900
Query: 901 FFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLV 960
FFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLV
Sbjct: 901 FFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLV 960
Query: 961 SAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACV 1020
SAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACV
Sbjct: 961 SAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACV 1020
Query: 1021 SALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGE 1080
SALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGE
Sbjct: 1021 SALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGE 1080
Query: 1081 TEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123
TEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
Sbjct: 1081 TEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123
>gi|62750347 histone deacetylase 5 isoform 1 [Homo sapiens]
Length = 1122
Score = 2228 bits (5773), Expect = 0.0
Identities = 1122/1123 (99%), Positives = 1122/1123 (99%), Gaps = 1/1123 (0%)
Query: 1 MNSPNESADGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVEL 60
MNSPNES DGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVEL
Sbjct: 1 MNSPNES-DGMSGREPSLEILPRTSLHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVEL 59
Query: 61 RGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQ 120
RGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQ
Sbjct: 60 RGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQ 119
Query: 121 QQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIA 180
QQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIA
Sbjct: 120 QQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIA 179
Query: 181 STEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYK 240
STEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYK
Sbjct: 180 STEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYK 239
Query: 241 LPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVE 300
LPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVE
Sbjct: 240 LPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVE 299
Query: 301 ITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPN 360
ITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPN
Sbjct: 300 ITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSPN 359
Query: 361 QFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMS 420
QFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMS
Sbjct: 360 QFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMS 419
Query: 421 TSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVAT 480
TSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVAT
Sbjct: 420 TSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLHGQSPLVTGERVAT 479
Query: 481 SMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTG 540
SMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTG
Sbjct: 480 SMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTG 539
Query: 541 ELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEE 600
ELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEE
Sbjct: 540 ELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEE 599
Query: 601 DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRT 660
DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRT
Sbjct: 600 DCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQVYQAPLSLATVPHQALGRT 659
Query: 661 QSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQ 720
QSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQ
Sbjct: 660 QSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQ 719
Query: 721 ETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVL 780
ETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVL
Sbjct: 720 ETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVL 779
Query: 781 PCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTA 840
PCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTA
Sbjct: 780 PCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTA 839
Query: 841 MGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGN 900
MGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGN
Sbjct: 840 MGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGN 899
Query: 901 FFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLV 960
FFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLV
Sbjct: 900 FFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLV 959
Query: 961 SAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACV 1020
SAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACV
Sbjct: 960 SAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACV 1019
Query: 1021 SALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGE 1080
SALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGE
Sbjct: 1020 SALLSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGE 1079
Query: 1081 TEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123
TEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL
Sbjct: 1080 TEEAETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1122
>gi|153085395 histone deacetylase 4 [Homo sapiens]
Length = 1084
Score = 1204 bits (3115), Expect = 0.0
Identities = 667/1149 (58%), Positives = 818/1149 (71%), Gaps = 94/1149 (8%)
Query: 3 SPNESADGMSGREPSLEILPRTSLHSIPVTVEVKPVLP-RAMPSSMGGGGGGSPSPVELR 61
S DG+SGR+ +E+L ++ +P TV+V LP + PS++ P++LR
Sbjct: 2 SSQSHPDGLSGRDQPVELLNPARVNHMPSTVDVATALPLQVAPSAV---------PMDLR 52
Query: 62 GALVGSV---DPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHL 118
S+ +P LREQQLQQELLALKQ+QQ+Q+Q+L AEFQ+QH+ L+RQHE QL +H+
Sbjct: 53 LDHQFSLPVAEPALREQQLQQELLALKQKQQIQRQILIAEFQRQHEQLSRQHEAQLHEHI 112
Query: 119 KQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQE-ELEKQRLEQQLLILRNKEKSKES 177
KQQQEMLA K QQE+L E QR+ E+ RQE ELEKQ EQ+L L+NKEK KES
Sbjct: 113 KQQQEMLAMKHQQELL--------EHQRKLERHRQEQELEKQHREQKLQQLKNKEKGKES 164
Query: 178 AIASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGT 235
A+ASTEVK++LQEF+L+K K LNH + P+ W H+SLDQSSPPQSG
Sbjct: 165 AVASTEVKMKLQEFVLNKKKALAHRNLNHCISSDPRYWYGKTQHSSLDQSSPPQSG---V 221
Query: 236 PPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFK 295
SY P+ G YD++DDFPLRKTASEPNLK+RSRLKQKVAERRSSPLLRRKDG V++ K
Sbjct: 222 STSYNHPVLGMYDAKDDFPLRKTASEPNLKLRSRLKQKVAERRSSPLLRRKDGPVVTALK 281
Query: 296 KRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTI-AENGFTGSVPNIPTEMLPQHRALP 354
KR +++T S C+SAPGSGPSSPN+S ++ AENG +VP+IP E HR +
Sbjct: 282 KRPLDVT------DSACSSAPGSGPSSPNNSSGSVSAENGIAPAVPSIPAETSLAHRLVA 335
Query: 355 LDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLST--QQEAERQALQSLRQG- 411
+ S LYTSPSLPNI+LGL AT P T QQ+AER L +L+Q
Sbjct: 336 REGSAAPLPLYTSPSLPNITLGLPAT----------GPSAGTAGQQDAERLTLPALQQRL 385
Query: 412 ----GTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLI----A 463
GT ++STS LE DG H+ LLQH++LLEQ Q+ L+ A
Sbjct: 386 SLFPGTHLTPYLSTSP---------LERDGGA-AHSPLLQHMVLLEQPPAQAPLVTGLGA 435
Query: 464 VPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLE 523
+PLH QS LV +RV+ S+ KL +HRPL RTQS+PLPQ+ QALQ LV+QQQHQQFLE
Sbjct: 436 LPLHAQS-LVGADRVSPSIH---KLRQHRPLGRTQSAPLPQNAQALQHLVIQQQHQQFLE 491
Query: 524 KQKQQ----QLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTE 579
K KQQ QLQ+ KI+ K E RQP +HPEETEEEL E Q +L +P +
Sbjct: 492 KHKQQFQQQQLQMNKIIPKPSEPARQPESHPEETEEELREHQALLDEPYLDRLPGQKEAH 551
Query: 580 SESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFSDAQPLQP 639
+++ + +E E D+ E E E E G + P +E + L + Q +
Sbjct: 552 AQAGVQVKQEPIESDEEEAEPP------REVEPGQRQ-PSEQELLFRQQALLLEQQRIHQ 604
Query: 640 LQVYQAPLSLATVP-----HQALGRTQSSPAAPGGMKSPPDQPVKHLFTTGVVYDTFMLK 694
L+ YQA + A +P H+ L R QSSPA+ S + P K FTTG+VYDT MLK
Sbjct: 605 LRNYQASMEAAGIPVSFGGHRPLSRAQSSPASATFPVSVQEPPTKPRFTTGLVYDTLMLK 664
Query: 695 HQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYG 754
HQC CG++ HPEHAGRIQSIWSRLQETGL KCE IRGRKATL+E+QTVHSE HTLLYG
Sbjct: 665 HQCTCGSSSSHPEHAGRIQSIWSRLQETGLRGKCECIRGRKATLEELQTVHSEAHTLLYG 724
Query: 755 TSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAF 814
T+PLNRQKLDSKKLLG ++ ++ LPCGG+GVDSDT+WNE+HS+ A R+AVGC++EL F
Sbjct: 725 TNPLNRQKLDSKKLLGSLAS-VFVRLPCGGVGVDSDTIWNEVHSAGAARLAVGCVVELVF 783
Query: 815 KVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHH 874
KVA GELKNGFA++RPPGHHAEEST MGFC+FNSVA+ AKLLQQ+L+V K+LIVDWD+HH
Sbjct: 784 KVATGELKNGFAVVRPPGHHAEESTPMGFCYFNSVAVAAKLLQQRLSVSKILIVDWDVHH 843
Query: 875 GNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIG 934
GNGTQQAFY+DPSVLY+SLHRYD+GNFFPGSGAP+EVG GPGVG+NVN+A+TGG+DPP+G
Sbjct: 844 GNGTQQAFYSDPSVLYMSLHRYDDGNFFPGSGAPDEVGTGPGVGFNVNMAFTGGLDPPMG 903
Query: 935 DVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTL 994
D EYL AFRTVVMPIA EF+PDVVLVS+GFDAVEGH +PLGGY+++ARCFG+LT+QLM L
Sbjct: 904 DAEYLAAFRTVVMPIASEFAPDVVLVSSGFDAVEGHPTPLGGYNLSARCFGYLTKQLMGL 963
Query: 995 AGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATLEKVIEI 1054
AGGR+VLALEGGHDLTAICDASEACVSALL EL PL E VLQQ+PN NAV ++EKV+EI
Sbjct: 964 AGGRIVLALEGGHDLTAICDASEACVSALLGNELDPLPEKVLQQRPNANAVRSMEKVMEI 1023
Query: 1055 QSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREHSPRPAE 1114
SK+W C+Q+ + GRSL EAQ E EEAETV+AMA LSVG + A+ RP E
Sbjct: 1024 HSKYWRCLQRTTSTAGRSLIEAQTCENEEAETVTAMASLSVGVKPAE--------KRPDE 1075
Query: 1115 EPMEQEPAL 1123
EPME+EP L
Sbjct: 1076 EPMEEEPPL 1084
>gi|30795204 histone deacetylase 9 isoform 5 [Homo sapiens]
Length = 1069
Score = 1173 bits (3035), Expect = 0.0
Identities = 653/1120 (58%), Positives = 801/1120 (71%), Gaps = 73/1120 (6%)
Query: 26 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82
+HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL
Sbjct: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
Query: 83 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142
++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K QQE+LA KQQQE+L +++Q+L
Sbjct: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIKLQQELLAIKQQQELL--EKEQKL 109
Query: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200
EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+
Sbjct: 110 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 164
Query: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258
G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT
Sbjct: 165 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 221
Query: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318
ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS
Sbjct: 222 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 276
Query: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376
GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG
Sbjct: 277 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 336
Query: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436
L A S L AS L +Q+ E Q +LRQG L G++ + V LEG
Sbjct: 337 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 389
Query: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494
H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL
Sbjct: 390 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 449
Query: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552
+RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE
Sbjct: 450 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 507
Query: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612
EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S
Sbjct: 508 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 557
Query: 613 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663
+E ++E +G + F L+P L V QAPL+ + H+ + RT SS
Sbjct: 558 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 615
Query: 664 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723
PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG
Sbjct: 616 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 675
Query: 724 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783
LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG
Sbjct: 676 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 735
Query: 784 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843
G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 736 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 795
Query: 844 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903
CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 796 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 855
Query: 904 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 963
GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG
Sbjct: 856 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 915
Query: 964 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1023
FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL
Sbjct: 916 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 975
Query: 1024 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1083
L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE
Sbjct: 976 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1033
Query: 1084 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123
ETVSA+A L+V EQ A + R A EPME+EPAL
Sbjct: 1034 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1069
>gi|30795202 histone deacetylase 9 isoform 4 [Homo sapiens]
Length = 1066
Score = 1165 bits (3013), Expect = 0.0
Identities = 651/1120 (58%), Positives = 799/1120 (71%), Gaps = 76/1120 (6%)
Query: 26 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82
+HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL
Sbjct: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
Query: 83 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142
++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K E+LA KQQQE+L +++Q+L
Sbjct: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106
Query: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200
EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+
Sbjct: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
Query: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258
G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT
Sbjct: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218
Query: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318
ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS
Sbjct: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273
Query: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376
GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG
Sbjct: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
Query: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436
L A S L AS L +Q+ E Q +LRQG L G++ + V LEG
Sbjct: 334 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386
Query: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494
H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL
Sbjct: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446
Query: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552
+RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE
Sbjct: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
Query: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612
EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S
Sbjct: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554
Query: 613 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663
+E ++E +G + F L+P L V QAPL+ + H+ + RT SS
Sbjct: 555 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 612
Query: 664 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723
PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG
Sbjct: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672
Query: 724 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783
LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG
Sbjct: 673 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 732
Query: 784 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843
G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 733 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 792
Query: 844 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903
CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 793 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
Query: 904 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 963
GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG
Sbjct: 853 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 912
Query: 964 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1023
FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL
Sbjct: 913 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 972
Query: 1024 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEE 1083
L EL+PL E +L Q PN+NAV +L+K+IEIQSK+W V+ A G +L AQ EE
Sbjct: 973 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQSKYWKSVRMVAVPRGCALAGAQL--QEE 1030
Query: 1084 AETVSAMALLSVGAEQAQAAAAREHSPRPAEEPMEQEPAL 1123
ETVSA+A L+V EQ A + R A EPME+EPAL
Sbjct: 1031 TETVSALASLTVDVEQPFA----QEDSRTAGEPMEEEPAL 1066
>gi|17158039 histone deacetylase 9 isoform 1 [Homo sapiens]
Length = 1011
Score = 1123 bits (2904), Expect = 0.0
Identities = 620/1053 (58%), Positives = 761/1053 (72%), Gaps = 70/1053 (6%)
Query: 26 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82
+HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL
Sbjct: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
Query: 83 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142
++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K E+LA KQQQE+L +++Q+L
Sbjct: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106
Query: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200
EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+
Sbjct: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
Query: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258
G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT
Sbjct: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218
Query: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318
ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS
Sbjct: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273
Query: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376
GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG
Sbjct: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
Query: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436
L A S L AS L +Q+ E Q +LRQG L G++ + V LEG
Sbjct: 334 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386
Query: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494
H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL
Sbjct: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446
Query: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552
+RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE
Sbjct: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
Query: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612
EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S
Sbjct: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554
Query: 613 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663
+E ++E +G + F L+P L V QAPL+ + H+ + RT SS
Sbjct: 555 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 612
Query: 664 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723
PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG
Sbjct: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672
Query: 724 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783
LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG
Sbjct: 673 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 732
Query: 784 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843
G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 733 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 792
Query: 844 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903
CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 793 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
Query: 904 GSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAG 963
GSGAP EVG G G GYN+N+AWTGG+DPP+GDVEYL AFRT+V P+A EF PD+VLVSAG
Sbjct: 853 GSGAPNEVGTGLGEGYNINIAWTGGLDPPMGDVEYLEAFRTIVKPVAKEFDPDMVLVSAG 912
Query: 964 FDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSAL 1023
FDA+EGH PLGGY VTA+CFGHLT+QLMTLA GRVVLALEGGHDLTAICDASEACV+AL
Sbjct: 913 FDALEGHTPPLGGYKVTAKCFGHLTKQLMTLADGRVVLALEGGHDLTAICDASEACVNAL 972
Query: 1024 LSVELQPLDEAVLQQKPNINAVATLEKVIEIQS 1056
L EL+PL E +L Q PN+NAV +L+K+IEIQS
Sbjct: 973 LGNELEPLAEDILHQSPNMNAVISLQKIIEIQS 1005
>gi|17158041 histone deacetylase 9 isoform 2 [Homo sapiens]
Length = 879
Score = 894 bits (2309), Expect = 0.0
Identities = 510/908 (56%), Positives = 634/908 (69%), Gaps = 70/908 (7%)
Query: 26 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82
+HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL
Sbjct: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
Query: 83 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142
++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K E+LA KQQQE+L +++Q+L
Sbjct: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106
Query: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200
EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+
Sbjct: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
Query: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258
G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT
Sbjct: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218
Query: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318
ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS
Sbjct: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273
Query: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376
GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG
Sbjct: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
Query: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436
L A S L AS L +Q+ E Q +LRQG L G++ + V LEG
Sbjct: 334 LPAVP----SQLNASNSLKEKQKCETQ---TLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386
Query: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494
H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL
Sbjct: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446
Query: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ--QQLQLGKILTKTGELPRQPTTHPEE 552
+RTQS+PLPQS L QLV+QQQHQQFLEKQKQ QQ+ + K+L+K+ E +QP +H EE
Sbjct: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
Query: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612
EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S
Sbjct: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554
Query: 613 GAEEGPDLEEPGAGYKKLFSDAQPLQP-----LQVYQAPLSLATVP----HQALGRTQSS 663
+E ++E +G + F L+P L V QAPL+ + H+ + RT SS
Sbjct: 555 --DEDAQIQEMESGEQAAFMQQPFLEPTHTRALSVRQAPLAAVGMDGLEKHRLVSRTHSS 612
Query: 664 PAAPGGMKSPPDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETG 723
PAA D+P++ TG+ YD MLKHQC+CGN+ HPEHAGRIQSIWSRLQETG
Sbjct: 613 PAASVLPHPAMDRPLQPGSATGIAYDPLMLKHQCVCGNSTTHPEHAGRIQSIWSRLQETG 672
Query: 724 LLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCG 783
LL+KCERI+GRKA+L+EIQ VHSE+H+LLYGT+PL+ QKLD + LLG SQK ++ LPCG
Sbjct: 673 LLNKCERIQGRKASLEEIQLVHSEHHSLLYGTNPLDGQKLDPRILLGDDSQKFFSSLPCG 732
Query: 784 GIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGF 843
G+GVDSDT+WNE+HSS A RMAVGC++ELA KVA+GELKNGFA++RPPGHHAEESTAMGF
Sbjct: 733 GLGVDSDTIWNELHSSGAARMAVGCVIELASKVASGELKNGFAVVRPPGHHAEESTAMGF 792
Query: 844 CFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP 903
CFFNSVAITAK L+ +LN+ K+LIVD D+HHGNGTQQAFY DPS+LYISLHRYD GNFFP
Sbjct: 793 CFFNSVAITAKYLRDQLNISKILIVDLDVHHGNGTQQAFYADPSILYISLHRYDEGNFFP 852
Query: 904 GSGAPEEV 911
GSGAP EV
Sbjct: 853 GSGAPNEV 860
>gi|169234807 histone deacetylase 7 isoform a [Homo sapiens]
Length = 991
Score = 721 bits (1860), Expect = 0.0
Identities = 462/1092 (42%), Positives = 607/1092 (55%), Gaps = 162/1092 (14%)
Query: 52 GGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHE 111
G P P++LR VG P E + LLAL++ Q+L H HL
Sbjct: 34 GPQPQPMDLR---VGQRPPV--EPPPEPTLLALQRPQRL------------HHHL----- 71
Query: 112 VQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNK 171
LA QQQ + +E R EL+ EQ+L L +K
Sbjct: 72 ------------FLAGLQQQ--------RSVEPMRLSMDTPMPELQVGPQEQELRQLLHK 111
Query: 172 EKSKESAIASTEVKLRLQEFLLSKSK-------EPTPGGLNHSLPQHPKCWGAHHASLDQ 224
+KSK SA+AS+ VK +L E +L K + P G+ + + + GA + L
Sbjct: 112 DKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSS 171
Query: 225 SSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLR 284
PP P PP + FPLRKT SEPNLK+R + K+ + ERR +PLLR
Sbjct: 172 FLPPVPSLPSDPPEH-------------FPLRKTVSEPNLKLRYKPKKSL-ERRKNPLLR 217
Query: 285 RKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPT 344
++ + ++R E G +SS S P SG SSPN S G P + +
Sbjct: 218 KESAP--PSLRRRPAETLGDSSPSSS---STPASGCSSPNDSEH--------GPNPILGS 264
Query: 345 EMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQA 404
E L R ++S F+L T LP I+LGL A + +++R+
Sbjct: 265 EALLGQRLRLQETSVAPFALPTVSLLPAITLGLPAPA---------------RADSDRRT 309
Query: 405 LQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAV 464
+L G + G + +P G+ E G+ S LQ +LLL+ + + L+ V
Sbjct: 310 HPTLGPRGPILGSPHTPLFLPH---GLEPEAGGTL---PSRLQPILLLDPSGSHAPLLTV 363
Query: 465 PLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEK 524
P G P + + T+ R G H PLSRT+S PLP S A Q +
Sbjct: 364 PGLGPLPFHFAQSLMTTERLSGS-GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLE---- 418
Query: 525 QKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQ 584
Q + +Q+ K K E PR E E +G +
Sbjct: 419 QLKTHVQVIKRSAKPSEKPRLRQIPSAEDLET------------------DGGGPGQVVD 460
Query: 585 EDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDL----EEPGAGYKKLFSDAQPLQPL 640
+ LE E G+ E G + ++ P + ++ AG S +
Sbjct: 461 DGLEHR-ELGHGQPEA--------RGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVL-- 509
Query: 641 QVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPP-----------DQPVKHL-FTTGVVY 688
L LA H+ L R QSSPAAP + +P + P + L FTTG++Y
Sbjct: 510 ------LPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIY 563
Query: 689 DTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEY 748
D+ MLKHQC CG+ HPEHAGRIQSIWSRLQE GL S+CE +RGRKA+L+E+Q+VHSE
Sbjct: 564 DSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSER 623
Query: 749 HTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGC 808
H LLYGT+PL+R KLD+ KL G ++Q+M+ +LPCGG+GVD+DT+WNE+HSS+A R A G
Sbjct: 624 HVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGS 683
Query: 809 LLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIV 868
+ +LAFKVA+ ELKNGFA++RPPGHHA+ STAMGFCFFNSVAI + LQQ+ K+LIV
Sbjct: 684 VTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIV 743
Query: 869 DWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGG 928
DWD+HHGNGTQQ FY DPSVLYISLHR+D+GNFFPGSGA +EVG G G G+NVNVAW GG
Sbjct: 744 DWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGG 803
Query: 929 VDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLT 988
+DPP+GD EYL AFR VVMPIA EFSPD+VLVSAGFDA EGH +PLGGY V+A+CFG++T
Sbjct: 804 LDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMT 863
Query: 989 RQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATL 1048
+QLM LAGG VVLALEGGHDLTAICDASEACV+ALL + PL E +QKPN+NA+ +L
Sbjct: 864 QQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSL 923
Query: 1049 EKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREH 1108
E VI + SK+W C+Q+ A+ + + EE E V+A+A LSVG
Sbjct: 924 EAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILA--------- 974
Query: 1109 SPRPAEEPMEQE 1120
RP+E+ +E+E
Sbjct: 975 EDRPSEQLVEEE 986
>gi|148539870 histone deacetylase 7 isoform d [Homo sapiens]
Length = 954
Score = 697 bits (1800), Expect = 0.0
Identities = 454/1092 (41%), Positives = 592/1092 (54%), Gaps = 199/1092 (18%)
Query: 52 GGSPSPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHE 111
G P P++LR VG P E + LLAL++ Q+L H HL
Sbjct: 34 GPQPQPMDLR---VGQRPPV--EPPPEPTLLALQRPQRL------------HHHL----- 71
Query: 112 VQLQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNK 171
LA QQQ + +E R EL+ EQ+L L +K
Sbjct: 72 ------------FLAGLQQQ--------RSVEPMRLSMDTPMPELQVGPQEQELRQLLHK 111
Query: 172 EKSKESAIASTEVKLRLQEFLLSKSK-------EPTPGGLNHSLPQHPKCWGAHHASLDQ 224
+KSK SA+AS+ VK +L E +L K + P G+ + + + GA + L
Sbjct: 112 DKSKRSAVASSVVKQKLAEVILKKQQAALERTVHPNSPGIPYRTLEPLETEGATRSMLSS 171
Query: 225 SSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLR 284
PP P PP + FPLRKT SEPNLK+R + K K ERR +PLLR
Sbjct: 172 FLPPVPSLPSDPPEH-------------FPLRKTVSEPNLKLRYKPK-KSLERRKNPLLR 217
Query: 285 RKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPT 344
++ + ++R E G +SS S P SG SSPN S E+G
Sbjct: 218 KESAP--PSLRRRPAETLGDSSPSSS---STPASGCSSPNDS-----EHG---------- 257
Query: 345 EMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQA 404
PN LG +A +++R+
Sbjct: 258 --------------------------PNPILGSEA-------------------DSDRRT 272
Query: 405 LQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAV 464
+L G + G + +P G+ E G+ S LQ +LLL+ + + L+ V
Sbjct: 273 HPTLGPRGPILGSPHTPLFLPH---GLEPEAGGT---LPSRLQPILLLDPSGSHAPLLTV 326
Query: 465 PLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEK 524
P G P + + T+ R G H PLSRT+S PLP S A Q +
Sbjct: 327 PGLGPLPFHFAQSLMTTERLSGS-GLHWPLSRTRSEPLPPSATAPPPPGPMQPRLE---- 381
Query: 525 QKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQ 584
Q + +Q+ K K E PR E E +G +
Sbjct: 382 QLKTHVQVIKRSAKPSEKPRLRQIPSAEDLE------------------TDGGGPGQVVD 423
Query: 585 EDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDL----EEPGAGYKKLFSDAQPLQPL 640
+ LE E G+ E G + ++ P + ++ AG S +
Sbjct: 424 DGLEHR-ELGHGQPE--------ARGPAPLQQHPQVLLWEQQRLAGRLPRGSTGDTVL-- 472
Query: 641 QVYQAPLSLATVPHQALGRTQSSPAAPGGMKSP-----------PDQPVKHL-FTTGVVY 688
L LA H+ L R QSSPAAP + +P + P + L FTTG++Y
Sbjct: 473 ------LPLAQGGHRPLSRAQSSPAAPASLSAPEPASQARVLSSSETPARTLPFTTGLIY 526
Query: 689 DTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEY 748
D+ MLKHQC CG+ HPEHAGRIQSIWSRLQE GL S+CE +RGRKA+L+E+Q+VHSE
Sbjct: 527 DSVMLKHQCSCGDNSRHPEHAGRIQSIWSRLQERGLRSQCECLRGRKASLEELQSVHSER 586
Query: 749 HTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGC 808
H LLYGT+PL+R KLD+ KL G ++Q+M+ +LPCGG+GVD+DT+WNE+HSS+A R A G
Sbjct: 587 HVLLYGTNPLSRLKLDNGKLAGLLAQRMFVMLPCGGVGVDTDTIWNELHSSNAARWAAGS 646
Query: 809 LLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIV 868
+ +LAFKVA+ ELKNGFA++RPPGHHA+ STAMGFCFFNSVAI + LQQ+ K+LIV
Sbjct: 647 VTDLAFKVASRELKNGFAVVRPPGHHADHSTAMGFCFFNSVAIACRQLQQQSKASKILIV 706
Query: 869 DWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGG 928
DWD+HHGNGTQQ FY DPSVLYISLHR+D+GNFFPGSGA +EVG G G G+NVNVAW GG
Sbjct: 707 DWDVHHGNGTQQTFYQDPSVLYISLHRHDDGNFFPGSGAVDEVGAGSGEGFNVNVAWAGG 766
Query: 929 VDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLT 988
+DPP+GD EYL AFR VVMPIA EFSPD+VLVSAGFDA EGH +PLGGY V+A+CFG++T
Sbjct: 767 LDPPMGDPEYLAAFRIVVMPIAREFSPDLVLVSAGFDAAEGHPAPLGGYHVSAKCFGYMT 826
Query: 989 RQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKPNINAVATL 1048
+QLM LAGG VVLALEGGHDLTAICDASEACV+ALL + PL E +QKPN+NA+ +L
Sbjct: 827 QQLMNLAGGAVVLALEGGHDLTAICDASEACVAALLGNRVDPLSEEGWKQKPNLNAIRSL 886
Query: 1049 EKVIEIQSKHWSCVQKFAAGLGRSLREAQAGETEEAETVSAMALLSVGAEQAQAAAAREH 1108
E VI + SK+W C+Q+ A+ + + EE E V+A+A LSVG
Sbjct: 887 EAVIRVHSKYWGCMQRLASCPDSWVPRVPGADKEEVEAVTALASLSVGILA--------- 937
Query: 1109 SPRPAEEPMEQE 1120
RP+E+ +E+E
Sbjct: 938 EDRPSEQLVEEE 949
>gi|7662280 histone deacetylase 9 isoform 3 [Homo sapiens]
Length = 590
Score = 498 bits (1282), Expect = e-140
Identities = 315/619 (50%), Positives = 403/619 (65%), Gaps = 61/619 (9%)
Query: 26 LHSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGAL---VGSVDPTLREQQLQQELL 82
+HS+ +V+VK +P + SP++LR L + VDP +RE+QLQQELL
Sbjct: 1 MHSMISSVDVKSEVPVGLEPI---------SPLDLRTDLRMMMPVVDPVVREKQLQQELL 51
Query: 83 ALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQEMLAAKRQQEL 142
++QQQQ+QKQLL AEFQKQH++LTRQH+ QLQ+H+K E+LA KQQQE+L +++Q+L
Sbjct: 52 LIQQQQQIQKQLLIAEFQKQHENLTRQHQAQLQEHIK---ELLAIKQQQELL--EKEQKL 106
Query: 143 EQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQEFLLSKS--KEPT 200
EQQRQ ++E+E+ R EQQL LR K++ +E A+ASTEVK +LQEFLLSKS K+
Sbjct: 107 EQQRQ-----EQEVERHRREQQLPPLRGKDRGRERAVASTEVKQKLQEFLLSKSATKDTP 161
Query: 201 PGGLNHSLPQHPKCW--GAHHASLDQSSPPQSGPPGTPPSYKLPLPGPYDSRDDFPLRKT 258
G NHS+ +HPK W AHH SLDQSSPP SG T PSYK LPG D++DDFPLRKT
Sbjct: 162 TNGKNHSVSRHPKLWYTAAHHTSLDQSSPPLSG---TSPSYKYTLPGAQDAKDDFPLRKT 218
Query: 259 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGS 318
ASEPNLKVRSRLKQKVAERRSSPLLRRKDG V+++FKKR E+T SSV +S+PGS
Sbjct: 219 ASEPNLKVRSRLKQKVAERRSSPLLRRKDGNVVTSFKKRMFEVT-----ESSVSSSSPGS 273
Query: 319 GPSSPNSSHSTIAENGFTGSVPNIP--TEMLPQHRALPLDSSPNQFSLYTSPSLPNISLG 376
GPSSPN+ + T +P P +M+ Q R L + S N SLYTSPSLPNI+LG
Sbjct: 274 GPSSPNNGPTGSVTENETSVLPPTPHAEQMVSQQRILIHEDSMNLLSLYTSPSLPNITLG 333
Query: 377 LQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGD 436
L A S L AS L +Q+ E Q+LRQG L G++ + V LEG
Sbjct: 334 LPA----VPSQLNASNSLKEKQKCE---TQTLRQGVPLPGQYGGSIPASSSHPHVTLEGK 386
Query: 437 GSPHGHASLLQHVLLLEQARQQSTLIA--VPLHGQSPLVTGERVATSMRTVGKLPRHRPL 494
H +LLQH+LL EQ RQQ L+A VPLH QSPL T ER++ +R KLPRHRPL
Sbjct: 387 PPNSSHQALLQHLLLKEQMRQQKLLVAGGVPLHPQSPLATKERISPGIRGTHKLPRHRPL 446
Query: 495 SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQK--QQQLQLGKILTKTGELPRQPTTHPEE 552
+RTQS+PLPQS L QLV+QQQHQQFLEKQK QQQ+ + K+L+K+ E +QP +H EE
Sbjct: 447 NRTQSAPLPQS--TLAQLVIQQQHQQFLEKQKQYQQQIHMNKLLSKSIEQLKQPGSHLEE 504
Query: 553 TEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGES 612
EEEL G+ A+ R S+ ST+ D DD + ++VK+E +S
Sbjct: 505 AEEELQ-------GDQAMQEDRAPSS-GNSTRSD--SSACVDDTLGQVGAVKVKEEPVDS 554
Query: 613 GAEEGPDLEEPGAGYKKLF 631
+E ++E +G + F
Sbjct: 555 --DEDAQIQEMESGEQAAF 571
>gi|13128864 histone deacetylase 6 [Homo sapiens]
Length = 1215
Score = 286 bits (732), Expect = 8e-77
Identities = 176/453 (38%), Positives = 249/453 (54%), Gaps = 40/453 (8%)
Query: 618 PDLEEPGAGYKKLFSDAQ-PLQPLQVYQAPL--SLATVPHQALGRTQSSPAAPGGMKSPP 674
P LE PGA + + L+ L+ + L S TV + + G PP
Sbjct: 408 PMLESPGAPCRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEEEGPWEPP 467
Query: 675 DQPVKHL----FTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCER 730
P+ TG+VYD M+ H C ++H HPE RI I RL+E GL +C
Sbjct: 468 VLPILTWPVLQSRTGLVYDQNMMNH-CNLWDSH-HPEVPQRILRIMCRLEELGLAGRCLT 525
Query: 731 IRGRKATLDEIQTVHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDS 789
+ R AT E+ T HS EY L T + ++L + +
Sbjct: 526 LTPRPATEAELLTCHSAEYVGHLRATEKMKTRELHRESS-------------------NF 566
Query: 790 DTVWNEMHSSSAVRMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSV 849
D+++ + + ++A G L V +GE+ NG A++RPPGHHAE+ A GFCFFNSV
Sbjct: 567 DSIYICPSTFACAQLATGAACRLVEAVLSGEVLNGAAVVRPPGHHAEQDAACGFCFFNSV 626
Query: 850 AITAKLLQQ-KLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSG 906
A+ A+ Q + ++LIVDWD+HHGNGTQ F +DPSVLY+SLHRYD+G FFP G
Sbjct: 627 AVAARHAQTISGHALRILIVDWDVHHGNGTQHMFEDDPSVLYVSLHRYDHGTFFPMGDEG 686
Query: 907 APEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDA 966
A ++G G G+ VNVAW G P +GD +YL A+ +V+PIA+EF+P++VLVSAGFDA
Sbjct: 687 ASSQIGRAAGTGFTVNVAWNG---PRMGDADYLAAWHRLVLPIAYEFNPELVLVSAGFDA 743
Query: 967 VEGHLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSV 1026
G PLGG V+ + HLT LM LA GR++L LEGG++LT+I ++ AC +LL
Sbjct: 744 ARG--DPLGGCQVSPEGYAHLTHLLMGLASGRIILILEGGYNLTSISESMAACTRSLLG- 800
Query: 1027 ELQPLDEAVLQQKPNINAVATLEKVIEIQSKHW 1059
P L + P A+A++ + I++ ++W
Sbjct: 801 --DPPPLLTLPRPPLSGALASITETIQVHRRYW 831
Score = 235 bits (599), Expect = 2e-61
Identities = 147/404 (36%), Positives = 213/404 (52%), Gaps = 33/404 (8%)
Query: 684 TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQT 743
TG+V D + + C+ ++ PE R+ +I +L + GLL +C + R A +E+
Sbjct: 86 TGLVLDEQLNEFHCLWDDSF--PEGPERLHAIKEQLIQEGLLDRCVSFQARFAEKEELML 143
Query: 744 VHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAV 802
VHS EY L+ T +N +L + D+V+ +S S
Sbjct: 144 VHSLEYIDLMETTQYMNEGELRV-------------------LADTYDSVYLHPNSYSCA 184
Query: 803 RMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 862
+A G +L L V E++NG AIIRPPGHHA+ S G+C FN VA+ A+ QQK +
Sbjct: 185 CLASGSVLRLVDAVLGAEIRNGMAIIRPPGHHAQHSLMDGYCMFNHVAVAARYAQQKHRI 244
Query: 863 GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAP--EEVGGGPGVGYN 920
+VLIVDWD+HHG GTQ F DPSVLY S+HRY+ G F+P A G G G GY
Sbjct: 245 RRVLIVDWDVHHGQGTQFTFDQDPSVLYFSIHRYEQGRFWPHLKASNWSTTGFGQGQGYT 304
Query: 921 VNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVT 980
+NV W + D +Y+ AF V++P+A EF P +VLV+AGFDA++G P G + T
Sbjct: 305 INVPWN---QVGMRDADYIAAFLHVLLPVALEFQPQLVLVAAGFDALQG--DPKGEMAAT 359
Query: 981 ARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP 1040
F LT LM LAGG+++L+LEGG++L A+ + A + LL P P
Sbjct: 360 PAGFAQLTHLLMGLAGGKLILSLEGGYNLRALAEGVSASLHTLLG---DPCPMLESPGAP 416
Query: 1041 NINAVATLEKVIEIQSKHWSCVQKFAAGLGR-SLREAQAGETEE 1083
+A A++ +E W + + + R ++ E E+EE
Sbjct: 417 CRSAQASVSCALEALEPFWEVLVRSTETVERDNMEEDNVEESEE 460
>gi|20070354 histone deacetylase 10 isoform 1 [Homo sapiens]
Length = 669
Score = 235 bits (600), Expect = 2e-61
Identities = 134/384 (34%), Positives = 207/384 (53%), Gaps = 30/384 (7%)
Query: 684 TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQT 743
T +VY M + + + E R+ + RL++ GL +C R+ R+A+ +E+
Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
Query: 744 VHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAV 802
VHS EY +L+ T L +++L + + D ++ +
Sbjct: 63 VHSPEYVSLVRETQVLGKEELQA-------------------LSGQFDAIYFHPSTFHCA 103
Query: 803 RMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 862
R+A G L+L V G ++NG A++RPPGHH + + A GFC FN+VAI A +QK +
Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
Query: 863 GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYN 920
++L+VDWD+HHG G Q F +DPSVLY S HRY++G F+P + VG G G+G+
Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
Query: 921 VNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVT 980
VN+ W +G+ +Y+ AF +++P+A EF P++VLVSAGFD+ G P G T
Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFEFDPELVLVSAGFDSAIG--DPEGQMQAT 278
Query: 981 ARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP 1040
CF HLT+ L LAGGRV LEGG+ L ++ ++ V LL PL + P
Sbjct: 279 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 335
Query: 1041 NINAVATLEKVIEIQSKHWSCVQK 1064
+A+ +++ Q+ HW +Q+
Sbjct: 336 CQSALESIQSARAAQAPHWKSLQQ 359
Score = 34.7 bits (78), Expect = 0.52
Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 11/73 (15%)
Query: 932 PIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL 991
P+ +L+ +V+P+A+ F PD+VLV+ G G+ + L L
Sbjct: 549 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 597
Query: 992 MTLAGGRVVLALE 1004
LAGGRV+ LE
Sbjct: 598 RGLAGGRVLALLE 610
>gi|226529806 histone deacetylase 10 isoform 2 [Homo sapiens]
Length = 649
Score = 204 bits (518), Expect = 5e-52
Identities = 122/384 (31%), Positives = 192/384 (50%), Gaps = 50/384 (13%)
Query: 684 TGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQT 743
T +VY M + + + E R+ + RL++ GL +C R+ R+A+ +E+
Sbjct: 3 TALVYHEDMTATRLLWDDPECEIERPERLTAALDRLRQRGLEQRCLRLSAREASEEELGL 62
Query: 744 VHS-EYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAV 802
VHS EY +L+ T L +++L + + D ++ +
Sbjct: 63 VHSPEYVSLVRETQVLGKEELQA-------------------LSGQFDAIYFHPSTFHCA 103
Query: 803 RMAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNV 862
R+A G L+L V G ++NG A++RPPGHH + + A GFC FN+VAI A +QK +
Sbjct: 104 RLAAGAGLQLVDAVLTGAVQNGLALVRPPGHHGQRAAANGFCVFNNVAIAAAHAKQKHGL 163
Query: 863 GKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFP--GSGAPEEVGGGPGVGYN 920
++L+VDWD+HHG G Q F +DPSVLY S HRY++G F+P + VG G G+G+
Sbjct: 164 HRILVVDWDVHHGQGIQYLFEDDPSVLYFSWHRYEHGRFWPFLRESDADAVGRGQGLGFT 223
Query: 921 VNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVT 980
VN+ W +G+ +Y+ AF +++P+A E G T
Sbjct: 224 VNLPWN---QVGMGNADYVAAFLHLLLPLAFE----------------------GQMQAT 258
Query: 981 ARCFGHLTRQLMTLAGGRVVLALEGGHDLTAICDASEACVSALLSVELQPLDEAVLQQKP 1040
CF HLT+ L LAGGRV LEGG+ L ++ ++ V LL PL + P
Sbjct: 259 PECFAHLTQLLQVLAGGRVCAVLEGGYHLESLAESVCMTVQTLLGDPAPPLSGPM---AP 315
Query: 1041 NINAVATLEKVIEIQSKHWSCVQK 1064
+A+ +++ Q+ HW +Q+
Sbjct: 316 CQSALESIQSARAAQAPHWKSLQQ 339
Score = 34.7 bits (78), Expect = 0.52
Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 11/73 (15%)
Query: 932 PIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQL 991
P+ +L+ +V+P+A+ F PD+VLV+ G G+ + L L
Sbjct: 529 PVMTGGFLSCILGLVLPLAYGFQPDLVLVALG-----------PGHGLQGPHAALLAAML 577
Query: 992 MTLAGGRVVLALE 1004
LAGGRV+ LE
Sbjct: 578 RGLAGGRVLALLE 590
>gi|116284376 histone deacetylase 2 [Homo sapiens]
Length = 582
Score = 106 bits (265), Expect = 1e-22
Identities = 82/291 (28%), Positives = 125/291 (42%), Gaps = 46/291 (15%)
Query: 705 HPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHS-EYHTLLYGTSPLNRQKL 763
HP RI+ + L GL K E R KAT +E+ HS EY L P N +
Sbjct: 123 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEY 182
Query: 764 DSKKLLGPISQKM--------YAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFK 815
+ + + + L GG V N + AV A G
Sbjct: 183 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVAGAVKLNRQQTDMAVNWAGGL------- 234
Query: 816 VAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHG 875
HHA++S A GFC+ N + + +L+ +VL +D DIHHG
Sbjct: 235 -----------------HHAKKSEASGFCYVNDIVLA--ILELLKYHQRVLYIDIDIHHG 275
Query: 876 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 935
+G ++AFY V+ +S H+Y G +FPG+G ++G G G Y VN G+D D
Sbjct: 276 DGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNFPMRDGID----D 329
Query: 936 VEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGH 986
Y F+ ++ + + P V++ G D++ G LG +++T + GH
Sbjct: 330 ESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSG--DRLGCFNLTVK--GH 376
>gi|13128860 histone deacetylase 1 [Homo sapiens]
Length = 482
Score = 105 bits (263), Expect = 2e-22
Identities = 83/291 (28%), Positives = 126/291 (43%), Gaps = 46/291 (15%)
Query: 705 HPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSE-YHTLLYGTSPLNRQKL 763
HP RI+ + L GL K E R KA +E+ HS+ Y L P N +
Sbjct: 28 HPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEY 87
Query: 764 DSKKLLGPISQKM--------YAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFK 815
+ + + + L GG V S N+ + AV A G
Sbjct: 88 SKQMQRFNVGEDCPVFDGLFEFCQLSTGG-SVASAVKLNKQQTDIAVNWAGGL------- 139
Query: 816 VAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHG 875
HHA++S A GFC+ N + + +L+ +VL +D DIHHG
Sbjct: 140 -----------------HHAKKSEASGFCYVNDIVLA--ILELLKYHQRVLYIDIDIHHG 180
Query: 876 NGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGD 935
+G ++AFY V+ +S H+Y G +FPG+G ++G G G Y VN G+D D
Sbjct: 181 DGVEEAFYTTDRVMTVSFHKY--GEYFPGTGDLRDIGAGKGKYYAVNYPLRDGID----D 234
Query: 936 VEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGH 986
Y F+ V+ + F P V++ G D++ G LG +++T + GH
Sbjct: 235 ESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSG--DRLGCFNLTIK--GH 281
>gi|8923769 histone deacetylase 8 [Homo sapiens]
Length = 377
Score = 95.9 bits (237), Expect = 2e-19
Identities = 87/346 (25%), Positives = 160/346 (46%), Gaps = 41/346 (11%)
Query: 674 PDQPVKHLFTTGVVYDTFMLKHQCMCGNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRG 733
P++P + VY + ++ MC + P+ A + S+ ++ L + ++
Sbjct: 4 PEEPADSGQSLVPVY-IYSPEYVSMCDSLAKIPKRASMVHSL---IEAYALHKQMRIVKP 59
Query: 734 RKATLDEIQTVHSEYHTLLYGTSPLNRQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVW 793
+ A+++E+ T H++ + L ++++ D P S + G+G D
Sbjct: 60 KVASMEEMATFHTDAY--LQHLQKVSQEGDDDH----PDSIEY-------GLGYDCPATE 106
Query: 794 NEMHSSSAVR----MAVGCLLELAFKVAAGELKNGFAIIRPPGHHAEESTAMGFCFFNSV 849
++A+ A CL++ KVA G+ HHA++ A GFC+ N
Sbjct: 107 GIFDYAAAIGGATITAAQCLIDGMCKVAIN-WSGGW-------HHAKKDEASGFCYLNDA 158
Query: 850 AITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYISLHRYDNGNFFPGSGAPE 909
+ L++K ++L VD D+HHG+G + AF V+ +SLH++ G FFPG+G
Sbjct: 159 VLGILRLRRKFE--RILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPG-FFPGTGDVS 215
Query: 910 EVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHEFSPDVVLVSAGFDAVEG 969
+VG G G Y+VNV G+ D +Y +V+ + F+P V++ G D + G
Sbjct: 216 DVGLGKGRYYSVNVPIQDGIQ----DEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAG 271
Query: 970 HLSPLGGYSVTARCFGHLTRQLMTLAGGRVVLALEGGHDL--TAIC 1013
P+ +++T G + ++ ++L GG++L TA C
Sbjct: 272 --DPMCSFNMTPVGIGKCLKYILQWQLATLILG-GGGYNLANTARC 314
>gi|13128862 histone deacetylase 3 [Homo sapiens]
Length = 428
Score = 89.4 bits (220), Expect = 2e-17
Identities = 57/172 (33%), Positives = 87/172 (50%), Gaps = 16/172 (9%)
Query: 833 HHAEESTAMGFCFFNSVAITAKLLQQKLNVGKVLIVDWDIHHGNGTQQAFYNDPSVLYIS 892
HHA++ A GFC+ N + I +L+ +VL +D DIHHG+G Q+AFY V+ +S
Sbjct: 134 HHAKKFEASGFCYVNDIVIG--ILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVS 191
Query: 893 LHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEYLTAFRTVVMPIAHE 952
H+Y N FFPG+G EVG G Y +NV G+D D Y F+ V+ +
Sbjct: 192 FHKYGN-YFFPGTGDMYEVGAESGRYYCLNVPLRDGID----DQSYKHLFQPVINQVVDF 246
Query: 953 FSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTR-------QLMTLAGG 997
+ P +++ G D++ LG ++++ R G L+ L GG
Sbjct: 247 YQPTCIVLQCGADSL--GCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGG 296
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 71.2 bits (173), Expect = 5e-12
Identities = 78/271 (28%), Positives = 121/271 (44%), Gaps = 32/271 (11%)
Query: 74 EQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAA--KQQQ 131
+Q+ ++ AL++QQ LQ+Q L ++ + RQ + QK ++QQ+E +QQ+
Sbjct: 360 QQENKERSEALRRQQLLQEQQL-----REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQR 414
Query: 132 EMLAAKRQQELEQQR--QREQQRQEELEKQRLEQQLL-----ILRNKEKSKESAIASTEV 184
A+RQQE EQ+R Q E++R EELE++R E++ R E+ +E E
Sbjct: 415 REREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEE 474
Query: 185 KLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLP 244
+ R E L + + L+ HP+ H+ Q PPQ + PS+ P P
Sbjct: 475 EQRHLEVLQQQLLQEQAMLLHDHRRPHPQ-----HS--QQPPPPQQ--ERSKPSFHAPEP 525
Query: 245 ----GPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKKRAVE 300
P D + P+R T+ P L R Q ++ S R ++ VE
Sbjct: 526 KAHYEPADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVE 585
Query: 301 ITGAGPGA-----SSVCNSAPGSGPSSPNSS 326
PG+ SS S PGS P S + S
Sbjct: 586 KLVPRPGSGSSSGSSNSGSQPGSHPGSQSGS 616
Score = 32.7 bits (73), Expect = 2.0
Identities = 43/202 (21%), Positives = 79/202 (39%), Gaps = 16/202 (7%)
Query: 422 SSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLH-GQSPLVTGERVAT 480
S I GCL+ ++ + LL+H + +Q ++ I + H ++ GE+ T
Sbjct: 264 SFIEGCLVKNYMQRPSTEQ----LLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDET 319
Query: 481 SMRTVGKLPRHRPLSRTQSSPLP------QSPQALQQLVMQQQHQQFLEKQKQQQLQLGK 534
G + + P +S L +QQ++++ E ++QQL +
Sbjct: 320 EYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQ 379
Query: 535 ILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEED 594
L + E RQ ++ E+ EQ+ L + E E + + EE+ +
Sbjct: 380 QLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLE 439
Query: 595 DGEEEEDCIQVKDEEGESGAEE 616
+ E K+EE AEE
Sbjct: 440 ELERRR-----KEEEERRRAEE 456
>gi|209862883 histone deacetylase 11 isoform 2 [Homo sapiens]
Length = 296
Score = 69.3 bits (168), Expect = 2e-11
Identities = 70/312 (22%), Positives = 125/312 (40%), Gaps = 64/312 (20%)
Query: 700 GNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLN 759
G +HP AG+ + + L+E LLS + R+A+ +++ VH+ + LN
Sbjct: 2 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 53
Query: 760 RQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG 819
K +K+L P+ + + G + V+ N
Sbjct: 54 ELK---RKVLRPLRTQTGGTIMAGKLAVERGWAIN------------------------- 85
Query: 820 ELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLN-VGKVLIVDWDIHHGNGT 878
+ GF HH GFC + + + K L +++ + + I+D D H GNG
Sbjct: 86 -VGGGF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGH 137
Query: 879 QQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEY 938
++ F +D V + ++ N + +PG ++ + V + W G + D EY
Sbjct: 138 ERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDEY 183
Query: 939 LTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGR 998
L + E PDVV+ +AG D +EG LGG S++ + + GR
Sbjct: 184 LDKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGR 241
Query: 999 ---VVLALEGGH 1007
+++ GG+
Sbjct: 242 RVPILMVTSGGY 253
>gi|55741807 TRAF2 and NCK interacting kinase isoform 1 [Homo
sapiens]
Length = 1360
Score = 66.6 bits (161), Expect = 1e-10
Identities = 125/556 (22%), Positives = 224/556 (40%), Gaps = 78/556 (14%)
Query: 69 DPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAA- 127
+ TLR L+ +L ++ + L++Q L + ++ +H RQ + QK +++Q+E
Sbjct: 347 ESTLRRDFLRLQLANKERSEALRRQQLEQQQRENEEH-KRQLLAERQKRIEEQKEQRRRL 405
Query: 128 -KQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKL 186
+QQ+ ++QQE EQ+R E+Q + E E++R E + +R + + ++ + + +L
Sbjct: 406 EEQQRREKELRKQQEREQRRHYEEQMRREEERRRAEHEQEYIRRQLEEEQRQLEILQQQL 465
Query: 187 RLQEFLL--SKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGPPGTPPSYKLPLP 244
++ LL K K+ L + K + SL Q P K PL
Sbjct: 466 LHEQALLLEYKRKQLEEQRQAERLQRQLKQERDYLVSLQHQRQEQR------PVEKKPL- 518
Query: 245 GPYDSRDDF-PLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVIS----TFKKRAV 299
Y ++ P K A ++ RSRL R+SSP + K IS + +
Sbjct: 519 --YHYKEGMSPSEKPAWAKEVEERSRL-----NRQSSPAMPHKVANRISDPNLPPRSESF 571
Query: 300 EITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPLDSSP 359
I+G P + P P P H ++ Q AL S
Sbjct: 572 SISGVQP-----ARTPPMLRPVDPQIPHLVAVKS---------------QGPALTASQSV 611
Query: 360 NQFSLYTSPSLPNISL-GLQATVTVTNSHLTASPKLSTQQEAERQALQS----------L 408
++ P L G Q + VT SH P+ ++ +E L + L
Sbjct: 612 HE--------QPTKGLSGFQEALNVT-SHRVEMPRQNSDPTSENPPLPTRIEKFDRSSWL 662
Query: 409 RQGGTLTGKF-MSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLH 467
RQ + K T+SI L G+GS G Q + +++ I
Sbjct: 663 RQEEDIPPKVPQRTTSISPALARKNSPGNGSALGPRLGSQPIRASNPDLRRTEPIL---- 718
Query: 468 GQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQ 527
+SPL +R ++ + P +P S+ S P Q+ + + V +
Sbjct: 719 -ESPL---QRTSSGSSSSSSTPSSQPSSQGGSQPGSQAGSSERTRVRANSKSEGSPVLPH 774
Query: 528 QQLQLGKILTKTGELPRQPTTHPEETEEELT----EQQEVLLGEGALTMPREGSTESEST 583
+ ++ ++ P +P ++ + +E+LT E +E+ + E M ++ + S S+
Sbjct: 775 EPAKVKPEESRDITRPSRPASYKKAIDEDLTALAKELRELRIEETNRPM-KKVTDYSSSS 833
Query: 584 QEDLEEEDEEDDGEEE 599
+E E+EE+DGE E
Sbjct: 834 EESESSEEEEEDGESE 849
>gi|221139761 zinc finger protein 853 [Homo sapiens]
Length = 659
Score = 66.2 bits (160), Expect = 2e-10
Identities = 53/152 (34%), Positives = 78/152 (51%), Gaps = 35/152 (23%)
Query: 76 QLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKH-LKQQQEMLAAKQQQEML 134
Q QQ+LL L+QQ QLQ+QLL + + L Q + QLQ+ L QQQE L +QQQ++L
Sbjct: 236 QQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLL 295
Query: 135 AAKR--------------------------------QQELEQQRQREQQRQEELEKQRLE 162
++ +QELEQQRQ E +RQ+ELE+Q+ +
Sbjct: 296 QQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQ-ELERQQELERQQEQ 354
Query: 163 QQL-LILRNKEKSKESAIASTEVKLRLQEFLL 193
+QL L L+ + + E + + +L QE L
Sbjct: 355 RQLQLKLQEELQQLEQQLEQQQQQLEQQEVQL 386
Score = 62.0 bits (149), Expect = 3e-09
Identities = 45/133 (33%), Positives = 79/133 (59%), Gaps = 8/133 (6%)
Query: 73 REQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQQQE 132
+EQQ+ Q+ L+QQ Q Q+ L + Q Q L +Q E Q+ +QQQE L +QQQ+
Sbjct: 183 QEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQQLLQQQEQLQQQQFQQQQEQL--QQQQQ 240
Query: 133 MLAAKRQQELEQ---QRQREQQRQEELEKQRLE-QQLLILRNKEKSKESAIASTEVKLRL 188
+L ++Q +L+Q Q+Q+ Q +Q+ LE+Q+ + QQ L+L+ +E+ ++ ++ +
Sbjct: 241 LLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQEQLQQQ--QQQQLLQQQ 298
Query: 189 QEFLLSKSKEPTP 201
QE L + +P P
Sbjct: 299 QEQLQQQQLQPPP 311
Score = 61.6 bits (148), Expect = 4e-09
Identities = 44/128 (34%), Positives = 77/128 (60%), Gaps = 11/128 (8%)
Query: 71 TLREQQLQQELLALKQQQQLQKQLLFAE--FQKQHDHL-----TRQHEVQLQKHLKQQ-Q 122
++ Q+L+ EL + QQQQLQ Q + + Q+Q + L Q +Q Q+ L+QQ Q
Sbjct: 140 SVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQ 199
Query: 123 EMLAAKQQQEMLAAKRQQELEQQRQREQQR-QEELEKQRLEQQLLILRNKEKSKESAIAS 181
E +QQQE L ++QQ L+QQ Q +QQ+ Q++ E+ + +QQLL+L+ + + ++ +
Sbjct: 200 EQQLLQQQQEQL--QQQQLLQQQEQLQQQQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQ 257
Query: 182 TEVKLRLQ 189
+ +L+ Q
Sbjct: 258 QQAQLQQQ 265
Score = 61.2 bits (147), Expect = 5e-09
Identities = 49/138 (35%), Positives = 80/138 (57%), Gaps = 22/138 (15%)
Query: 73 REQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEV-------QLQKHLKQQQEML 125
+++QLQQ+ L L+QQ+QLQ+Q +FQ+Q + L +Q ++ QLQ+ L QQQ+
Sbjct: 207 QQEQLQQQQL-LQQQEQLQQQ----QFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQ 261
Query: 126 AAKQQQEMLAAKRQQE--LEQQRQREQQRQEEL---EKQRLEQQLLILRNKEKSKESAIA 180
+Q E A+ QQ+ L+QQ Q +QQ+Q++L ++++L+QQ L E +E
Sbjct: 262 LQQQLLEQQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEE--- 318
Query: 181 STEVKLRLQEFLLSKSKE 198
EV+L L L +E
Sbjct: 319 --EVELELMPVDLGSEQE 334
Score = 60.8 bits (146), Expect = 7e-09
Identities = 44/149 (29%), Positives = 77/149 (51%), Gaps = 16/149 (10%)
Query: 75 QQLQQELLALKQQQQLQKQLLF-----------AEFQKQHDHLTRQHEVQLQKHLKQQQE 123
QQ QQ+ L +QQ+QLQ+Q L E + L + E++ Q+ ++Q+
Sbjct: 287 QQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMPVDLGSEQELEQQRQELERQQ 346
Query: 124 MLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTE 183
L +Q+Q L K Q+EL+Q Q+ +Q+Q++LE+Q ++ +L + + +E + T
Sbjct: 347 ELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQLELTPVELGAQQQEVQLELTP 406
Query: 184 VKLRLQEFLLSKSKEPTPGGLNHSLPQHP 212
V+ LQ L+ P GG ++P P
Sbjct: 407 VQPELQLELV-----PAAGGGGAAVPGAP 430
Score = 58.2 bits (139), Expect = 4e-08
Identities = 42/123 (34%), Positives = 71/123 (57%), Gaps = 6/123 (4%)
Query: 74 EQQLQQELLALKQQ--QQLQKQLLFAEFQKQHDHLTRQ-HEVQLQKHLKQQQEMLAAKQQ 130
+Q QQ+L L+Q+ Q + Q L E Q H Q +VQ Q+ L+QQQE L +Q
Sbjct: 123 QQDGQQQLSQLQQEKHQSVHHQELKPELQLMHQQQQLQPQQVQEQQRLQQQQEQLQTQQA 182
Query: 131 QEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQE 190
QE ++Q++L QQ+ +EQQ ++ ++Q +QQL L+ +E+ ++ + +L+ Q+
Sbjct: 183 QEQQVLQQQEQL-QQQVQEQQLLQQQQEQLQQQQL--LQQQEQLQQQQFQQQQEQLQQQQ 239
Query: 191 FLL 193
LL
Sbjct: 240 QLL 242
Score = 58.2 bits (139), Expect = 4e-08
Identities = 43/129 (33%), Positives = 75/129 (58%), Gaps = 9/129 (6%)
Query: 73 REQQLQQELLALKQQQQLQKQ---LLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQ 129
+++QLQQ+ +QQ+QLQ+Q LL + + L +Q + QLQ+ L +QQ+ A Q
Sbjct: 219 QQEQLQQQQFQ-QQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQ--AQLQ 275
Query: 130 QQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKLRLQ 189
QQ +L + Q + +QQ+Q QQ+QE+L++Q+L+ L E+ +E + V L +
Sbjct: 276 QQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPL---EPEEEEEVELELMPVDLGSE 332
Query: 190 EFLLSKSKE 198
+ L + +E
Sbjct: 333 QELEQQRQE 341
Score = 57.0 bits (136), Expect = 1e-07
Identities = 58/195 (29%), Positives = 91/195 (46%), Gaps = 52/195 (26%)
Query: 44 PSSMGGGGGGSPSPVELR-------------GALVGSVD------PTLREQQLQQELLAL 84
P ++ GG GGS S E A VG+ + P RE QLQQ L
Sbjct: 39 PDTLSGGSGGSESQEEEEPQERNSSPQRPAVSAPVGASEIAEETRPGQRELQLQQ----L 94
Query: 85 KQQQQLQKQLLFAEFQKQHDHLTRQH-----------EVQLQKH-------------LKQ 120
+QQ + Q+Q + Q+ HL Q ++Q +KH L
Sbjct: 95 EQQPEPQQQPQHEQLQQPQPHLELQQQPQQDGQQQLSQLQQEKHQSVHHQELKPELQLMH 154
Query: 121 QQEMLAAKQQQEMLAAKRQQE-LEQQRQREQ---QRQEELEKQRLEQQLLILRNKEKSKE 176
QQ+ L +Q QE ++QQE L+ Q+ +EQ Q+QE+L++Q EQQLL + +E+ ++
Sbjct: 155 QQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLL-QQQQEQLQQ 213
Query: 177 SAIASTEVKLRLQEF 191
+ + +L+ Q+F
Sbjct: 214 QQLLQQQEQLQQQQF 228
Score = 53.1 bits (126), Expect = 1e-06
Identities = 57/225 (25%), Positives = 99/225 (44%), Gaps = 27/225 (12%)
Query: 453 EQARQQSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQL 512
EQ +QQ L+ + GQ ++ ++ + L Q + L Q QQ
Sbjct: 233 EQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQ--------QQLLEQQQAQLQQQLLLQQQE 284
Query: 513 VMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTM 572
+QQQ QQ L +Q+Q+QLQ ++ + P PEE EE E V LG
Sbjct: 285 QLQQQQQQQLLQQQQEQLQQQQL--------QPPPLEPEEEEEVELELMPVDLG------ 330
Query: 573 PREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLEEPGAGYKKLFS 632
E E +++LE + +E + ++E+ +Q+K +E E+ + ++ +++
Sbjct: 331 ---SEQELEQQRQELERQ-QELERQQEQRQLQLKLQEELQQLEQQLEQQQQQLEQQEVQL 386
Query: 633 DAQPLQPLQVYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQP 677
+ P++ L Q + L P Q + + PAA GG + P P
Sbjct: 387 ELTPVE-LGAQQQEVQLELTPVQPELQLELVPAAGGGGAAVPGAP 430
Score = 41.2 bits (95), Expect = 0.006
Identities = 75/343 (21%), Positives = 126/343 (36%), Gaps = 39/343 (11%)
Query: 284 RRKDGTVISTFKKRAVEITGAGPGASSVCNSAPGSG------PSSPNSSHSTIAENGFTG 337
R + G TF + GPG ++ + GS P NSS A + G
Sbjct: 15 RMEVGPATETFVLELQCLEDGGPGPDTLSGGSGGSESQEEEEPQERNSSPQRPAVSAPVG 74
Query: 338 SVPNIPTEMLPQHRALPLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQ 397
+ I E P R L L Q P + P L Q
Sbjct: 75 A-SEIAEETRPGQRELQLQQLEQQPEPQQQPQHEQLQ--------------QPQPHLELQ 119
Query: 398 QEAERQALQSLRQGGTLTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQ 457
Q+ ++ Q L Q + + + P Q L +Q ++
Sbjct: 120 QQPQQDGQQQLSQLQQEKHQSVHHQEL-------------KPELQLMHQQQQLQPQQVQE 166
Query: 458 QSTLIAVPLHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQ 517
Q L Q+ ++V + + + + L + Q L Q Q LQQ QQ
Sbjct: 167 QQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQLQQQ-QLLQQQEQLQQ 225
Query: 518 HQQFLEKQKQ-QQLQLGKILTKTGELPRQPTTHPE-ETEEELTEQQEVLLGEGALTMPRE 575
QQF ++Q+Q QQ Q +L + G+L +Q + + +++L EQQ+ L + L +E
Sbjct: 226 -QQFQQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLEQQQAQLQQQLLLQQQE 284
Query: 576 GSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGP 618
+ + Q+ L+++ E+ ++ + +EE E E P
Sbjct: 285 -QLQQQQQQQLLQQQQEQLQQQQLQPPPLEPEEEEEVELELMP 326
Score = 33.9 bits (76), Expect = 0.89
Identities = 38/165 (23%), Positives = 72/165 (43%), Gaps = 40/165 (24%)
Query: 494 LSRTQSSPLPQSPQALQQLVMQQ--------QHQQFLE---------------KQKQQQL 530
L Q PQ Q Q+L QQ Q QQ L+ +Q+Q+QL
Sbjct: 152 LMHQQQQLQPQQVQEQQRLQQQQEQLQTQQAQEQQVLQQQEQLQQQVQEQQLLQQQQEQL 211
Query: 531 QLGKILTKTGELPRQPTTHPEETEEELTEQQEVLL--GEGALTMPREGSTESESTQEDLE 588
Q ++L + +L +Q ++ +E+L +QQ++LL +G L +++ Q+ LE
Sbjct: 212 QQQQLLQQQEQLQQQQF---QQQQEQLQQQQQLLLLQQQGQLQQQLLQQQQAQLQQQLLE 268
Query: 589 ------------EEDEEDDGEEEEDCIQVKDEEGESGAEEGPDLE 621
++ E+ ++++ +Q + E+ + + P LE
Sbjct: 269 QQQAQLQQQLLLQQQEQLQQQQQQQLLQQQQEQLQQQQLQPPPLE 313
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 65.1 bits (157), Expect = 4e-10
Identities = 83/316 (26%), Positives = 130/316 (41%), Gaps = 68/316 (21%)
Query: 74 EQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAA--KQQQ 131
+Q+ ++ AL++QQ LQ+Q L ++ + RQ + QK ++QQ+E +QQ+
Sbjct: 360 QQENKERSEALRRQQLLQEQQL-----REQEEYKRQLLAERQKRIEQQKEQRRRLEEQQR 414
Query: 132 EMLAAKRQQELEQQR--QREQQRQEELEKQRLE----------------QQLLILRNKEK 173
A+RQQE EQ+R Q E++R EELE++R E +Q I R E+
Sbjct: 415 REREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEE 474
Query: 174 SKESAIASTEVKLRLQEFLL--------SKSKEPTPGGLNHSLPQ-HPKCWGAHHASLDQ 224
+ + L+ Q LL S++P P S P H AH+ D+
Sbjct: 475 EQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEPADR 534
Query: 225 S------------SPPQSGPPGTPPSYKLPLPGPYDSRDD------FPLRKTASEPNLKV 266
+ S P++ T + P+P +S + P + +EP + V
Sbjct: 535 AREVEDRFRKTNHSSPEAQSKQTGRVLEPPVPSRSESFSNGNSESVHPALQRPAEPQVPV 594
Query: 267 RSRLKQKVAERRSSPL-----------LRRKDGTVISTFKKRAVEITGAGPGA-----SS 310
R+ + V RR SPL R ++ VE PG+ SS
Sbjct: 595 RTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKLVPRPGSGSSSGSS 654
Query: 311 VCNSAPGSGPSSPNSS 326
S PGS P S + S
Sbjct: 655 NSGSQPGSHPGSQSGS 670
Score = 32.7 bits (73), Expect = 2.0
Identities = 43/202 (21%), Positives = 79/202 (39%), Gaps = 16/202 (7%)
Query: 422 SSIPGCLLGVALEGDGSPHGHASLLQHVLLLEQARQQSTLIAVPLH-GQSPLVTGERVAT 480
S I GCL+ ++ + LL+H + +Q ++ I + H ++ GE+ T
Sbjct: 264 SFIEGCLVKNYMQRPSTEQ----LLKHPFIRDQPNERQVRIQLKDHIDRTRKKRGEKDET 319
Query: 481 SMRTVGKLPRHRPLSRTQSSPLP------QSPQALQQLVMQQQHQQFLEKQKQQQLQLGK 534
G + + P +S L +QQ++++ E ++QQL +
Sbjct: 320 EYEYSGSEEEEEEVPEQEGEPSSIVNVPGESTLRRDFLRLQQENKERSEALRRQQLLQEQ 379
Query: 535 ILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEED 594
L + E RQ ++ E+ EQ+ L + E E + + EE+ +
Sbjct: 380 QLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRRLE 439
Query: 595 DGEEEEDCIQVKDEEGESGAEE 616
+ E K+EE AEE
Sbjct: 440 ELERRR-----KEEEERRRAEE 456
>gi|17017963 forkhead box P2 isoform I [Homo sapiens]
Length = 715
Score = 63.9 bits (154), Expect = 8e-10
Identities = 40/120 (33%), Positives = 68/120 (56%), Gaps = 2/120 (1%)
Query: 56 SPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQ 115
SP +L+ L L++QQLQ+ KQQ+QL QLL + Q+Q +Q + Q Q
Sbjct: 114 SPQQLQALLQQQQAVMLQQQQLQE--FYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQ 171
Query: 116 KHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSK 175
+ +QQQ+ +QQQ+ +Q EQQ+Q++QQ+Q ++ +QQLL ++ ++ +
Sbjct: 172 QQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQ 231
Score = 59.7 bits (143), Expect = 2e-08
Identities = 40/135 (29%), Positives = 75/135 (55%), Gaps = 12/135 (8%)
Query: 68 VDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAA 127
+ P + LQQ+ + QQQQLQ+ ++KQ + L H LQ+ +QQQ+
Sbjct: 113 LSPQQLQALLQQQQAVMLQQQQLQE-----FYKKQQEQL---HLQLLQQQQQQQQQQQQQ 164
Query: 128 KQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEV--- 184
+QQQ+ ++QQ+ +QQ+Q++QQ+Q+ KQ EQQ + ++ + + + ++
Sbjct: 165 QQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQM 224
Query: 185 -KLRLQEFLLSKSKE 198
+L+ Q+ LLS ++
Sbjct: 225 QQLQQQQHLLSLQRQ 239
Score = 57.4 bits (137), Expect = 8e-08
Identities = 38/110 (34%), Positives = 66/110 (60%), Gaps = 8/110 (7%)
Query: 57 PVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQK 116
P+++ ++ + QQ+QQ L QQQ L Q L A Q+Q + +Q QLQ+
Sbjct: 84 PLQVPVSVAMMTPQVITPQQMQQIL----QQQVLSPQQLQALLQQQQAVMLQQQ--QLQE 137
Query: 117 HLKQQQEMLAAK--QQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQ 164
K+QQE L + QQQ+ ++QQ+ +QQ+Q++QQ+Q++ ++Q+ +QQ
Sbjct: 138 FYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 187
Score = 49.7 bits (117), Expect = 2e-05
Identities = 35/95 (36%), Positives = 56/95 (58%), Gaps = 9/95 (9%)
Query: 72 LREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHL-KQQQEMLAAKQQ 130
L++QQ QQ+ +QQQQ Q+Q + Q+Q +Q + Q Q+H KQ +E +QQ
Sbjct: 151 LQQQQQQQQ----QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQ 206
Query: 131 QEMLAAK----RQQELEQQRQREQQRQEELEKQRL 161
Q+ LAA+ +QQ L+ Q+ ++QQ L++Q L
Sbjct: 207 QQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGL 241
Score = 38.5 bits (88), Expect = 0.036
Identities = 49/258 (18%), Positives = 105/258 (40%), Gaps = 40/258 (15%)
Query: 453 EQARQQSTLIAVPLHGQSPLVTGERVATSMRTVG---------KLPRHRPLSRTQSSPLP 503
+ + + ST+ + L Q L ++ +T G + P P+S +P
Sbjct: 39 DTSSEVSTVELLHLQQQQALQAARQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQV 98
Query: 504 QSPQALQQLVMQQ-----QHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELT 558
+PQ +QQ++ QQ Q Q L Q+QQ + L + + +Q H + +++
Sbjct: 99 ITPQQMQQILQQQVLSPQQLQALL--QQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQ 156
Query: 559 EQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGP 618
+QQ+ + ++ + + Q+ +++ ++ G++ ++ Q + ++ + A++
Sbjct: 157 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQ-- 214
Query: 619 DLEEPGAGYKKLFSDAQPLQPLQ---------VYQAPLSLATVPHQALGRTQSSPA---- 665
+++ Q LQ Q + P A +P Q+L + SPA
Sbjct: 215 ------LVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQ 268
Query: 666 ---APGGMKSPPDQPVKH 680
G+ S D +KH
Sbjct: 269 LWKEVTGVHSMEDNGIKH 286
Score = 38.1 bits (87), Expect = 0.047
Identities = 32/112 (28%), Positives = 56/112 (50%), Gaps = 20/112 (17%)
Query: 73 REQQLQQELLALK------QQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLA 126
R+ LQQ+ LK +Q+ LQ + A Q + ++ Q+ L QQ
Sbjct: 62 RQLLLQQQTSGLKSPKSSDKQRPLQVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQAL 121
Query: 127 AKQQQEMLAA--------KRQQE------LEQQRQREQQRQEELEKQRLEQQ 164
+QQQ ++ K+QQE L+QQ+Q++QQ+Q++ ++Q+ +QQ
Sbjct: 122 LQQQQAVMLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQ 173
>gi|22538413 forkhead box P2 isoform III [Homo sapiens]
Length = 623
Score = 63.9 bits (154), Expect = 8e-10
Identities = 40/120 (33%), Positives = 68/120 (56%), Gaps = 2/120 (1%)
Query: 56 SPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQ 115
SP +L+ L L++QQLQ+ KQQ+QL QLL + Q+Q +Q + Q Q
Sbjct: 22 SPQQLQALLQQQQAVMLQQQQLQE--FYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQ 79
Query: 116 KHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSK 175
+ +QQQ+ +QQQ+ +Q EQQ+Q++QQ+Q ++ +QQLL ++ ++ +
Sbjct: 80 QQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQ 139
Score = 59.7 bits (143), Expect = 2e-08
Identities = 40/135 (29%), Positives = 75/135 (55%), Gaps = 12/135 (8%)
Query: 68 VDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAA 127
+ P + LQQ+ + QQQQLQ+ ++KQ + L H LQ+ +QQQ+
Sbjct: 21 LSPQQLQALLQQQQAVMLQQQQLQE-----FYKKQQEQL---HLQLLQQQQQQQQQQQQQ 72
Query: 128 KQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEV--- 184
+QQQ+ ++QQ+ +QQ+Q++QQ+Q+ KQ EQQ + ++ + + + ++
Sbjct: 73 QQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQM 132
Query: 185 -KLRLQEFLLSKSKE 198
+L+ Q+ LLS ++
Sbjct: 133 QQLQQQQHLLSLQRQ 147
Score = 56.6 bits (135), Expect = 1e-07
Identities = 37/92 (40%), Positives = 59/92 (64%), Gaps = 8/92 (8%)
Query: 75 QQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAK--QQQE 132
QQ+QQ L QQQ L Q L A Q+Q + +Q QLQ+ K+QQE L + QQQ+
Sbjct: 10 QQMQQIL----QQQVLSPQQLQALLQQQQAVMLQQQ--QLQEFYKKQQEQLHLQLLQQQQ 63
Query: 133 MLAAKRQQELEQQRQREQQRQEELEKQRLEQQ 164
++QQ+ +QQ+Q++QQ+Q++ ++Q+ +QQ
Sbjct: 64 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 95
Score = 49.7 bits (117), Expect = 2e-05
Identities = 35/95 (36%), Positives = 56/95 (58%), Gaps = 9/95 (9%)
Query: 72 LREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHL-KQQQEMLAAKQQ 130
L++QQ QQ+ +QQQQ Q+Q + Q+Q +Q + Q Q+H KQ +E +QQ
Sbjct: 59 LQQQQQQQQ----QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQ 114
Query: 131 QEMLAAK----RQQELEQQRQREQQRQEELEKQRL 161
Q+ LAA+ +QQ L+ Q+ ++QQ L++Q L
Sbjct: 115 QQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGL 149
Score = 35.4 bits (80), Expect = 0.31
Identities = 40/198 (20%), Positives = 84/198 (42%), Gaps = 46/198 (23%)
Query: 503 PQSPQAL----QQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELT 558
PQ QAL Q +++QQQ Q K++Q+QL L +L +Q ++ +++
Sbjct: 23 PQQLQALLQQQQAVMLQQQQLQEFYKKQQEQLHL--------QLLQQQQQQQQQQQQQQQ 74
Query: 559 EQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGP 618
+QQ+ ++ + + Q+ +++ ++ G++ ++ Q + ++ + A++
Sbjct: 75 QQQQ----------QQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQ-- 122
Query: 619 DLEEPGAGYKKLFSDAQPLQPLQ---------VYQAPLSLATVPHQALGRTQSSPA---- 665
+++ Q LQ Q + P A +P Q+L + SPA
Sbjct: 123 ------LVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLPQAGLSPAEIQQ 176
Query: 666 ---APGGMKSPPDQPVKH 680
G+ S D +KH
Sbjct: 177 LWKEVTGVHSMEDNGIKH 194
Score = 33.1 bits (74), Expect = 1.5
Identities = 23/72 (31%), Positives = 31/72 (43%), Gaps = 13/72 (18%)
Query: 491 HRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHP 550
H L + Q Q Q QQ QQQ QQ ++Q+QQQ Q Q HP
Sbjct: 55 HLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ-------------QQQQHP 101
Query: 551 EETEEELTEQQE 562
+ +E +QQ+
Sbjct: 102 GKQAKEQQQQQQ 113
Score = 31.6 bits (70), Expect = 4.4
Identities = 21/67 (31%), Positives = 31/67 (46%)
Query: 498 QSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEEL 557
Q Q Q QQ QQQ QQ ++Q+QQQ Q + E +Q + ++L
Sbjct: 64 QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQL 123
Query: 558 TEQQEVL 564
QQ++L
Sbjct: 124 VFQQQLL 130
>gi|149999352 forkhead box P2 isoform II [Homo sapiens]
Length = 740
Score = 63.9 bits (154), Expect = 8e-10
Identities = 40/120 (33%), Positives = 68/120 (56%), Gaps = 2/120 (1%)
Query: 56 SPVELRGALVGSVDPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQ 115
SP +L+ L L++QQLQ+ KQQ+QL QLL + Q+Q +Q + Q Q
Sbjct: 139 SPQQLQALLQQQQAVMLQQQQLQE--FYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQ 196
Query: 116 KHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSK 175
+ +QQQ+ +QQQ+ +Q EQQ+Q++QQ+Q ++ +QQLL ++ ++ +
Sbjct: 197 QQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQQLQQQQ 256
Score = 61.2 bits (147), Expect = 5e-09
Identities = 55/194 (28%), Positives = 99/194 (51%), Gaps = 20/194 (10%)
Query: 14 REPSLEILPRTSL----HSIPVTVEVKPVLPRAMPSSMGGGGGGSPSPVELRGALVGSV- 68
+ P E+LP T L HS + + P A+P S+ +P +++ L V
Sbjct: 82 QRPLQELLPETKLCICGHS---SGDGHPHNTFAVPVSVAMMTPQVITPQQMQQILQQQVL 138
Query: 69 DPTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAK 128
P + LQQ+ + QQQQLQ+ ++KQ + L H LQ+ +QQQ+ +
Sbjct: 139 SPQQLQALLQQQQAVMLQQQQLQE-----FYKKQQEQL---HLQLLQQQQQQQQQQQQQQ 190
Query: 129 QQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEV---- 184
QQQ+ ++QQ+ +QQ+Q++QQ+Q+ KQ EQQ + ++ + + + ++
Sbjct: 191 QQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLLQMQ 250
Query: 185 KLRLQEFLLSKSKE 198
+L+ Q+ LLS ++
Sbjct: 251 QLQQQQHLLSLQRQ 264
Score = 49.7 bits (117), Expect = 2e-05
Identities = 35/95 (36%), Positives = 56/95 (58%), Gaps = 9/95 (9%)
Query: 72 LREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHL-KQQQEMLAAKQQ 130
L++QQ QQ+ +QQQQ Q+Q + Q+Q +Q + Q Q+H KQ +E +QQ
Sbjct: 176 LQQQQQQQQ----QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQQ 231
Query: 131 QEMLAAK----RQQELEQQRQREQQRQEELEKQRL 161
Q+ LAA+ +QQ L+ Q+ ++QQ L++Q L
Sbjct: 232 QQQLAAQQLVFQQQLLQMQQLQQQQHLLSLQRQGL 266
Score = 36.6 bits (83), Expect = 0.14
Identities = 41/209 (19%), Positives = 88/209 (42%), Gaps = 31/209 (14%)
Query: 493 PLSRTQSSPLPQSPQALQQLVMQQ-----QHQQFLEKQKQQQLQLGKILTKTGELPRQPT 547
P+S +P +PQ +QQ++ QQ Q Q L Q+QQ + L + + +Q
Sbjct: 113 PVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALL--QQQQAVMLQQQQLQEFYKKQQEQ 170
Query: 548 THPEETEEELTEQQEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKD 607
H + +++ +QQ+ + ++ + + Q+ +++ ++ G++ ++ Q +
Sbjct: 171 LHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQHPGKQAKEQQQQQQ 230
Query: 608 EEGESGAEEGPDLEEPGAGYKKLFSDAQPLQPLQ---------VYQAPLSLATVPHQALG 658
++ + A++ +++ Q LQ Q + P A +P Q+L
Sbjct: 231 QQQQLAAQQ--------LVFQQQLLQMQQLQQQQHLLSLQRQGLISIPPGQAALPVQSLP 282
Query: 659 RTQSSPA-------APGGMKSPPDQPVKH 680
+ SPA G+ S D +KH
Sbjct: 283 QAGLSPAEIQQLWKEVTGVHSMEDNGIKH 311
Score = 32.0 bits (71), Expect = 3.4
Identities = 37/154 (24%), Positives = 61/154 (39%), Gaps = 17/154 (11%)
Query: 427 CLLGVALEGDGSPHGHASLLQHVLLL----------EQARQQSTL----IAVPLHGQSPL 472
C+ G + GDG PH ++ V ++ +Q QQ L + L Q +
Sbjct: 95 CICGHS-SGDGHPHNTFAVPVSVAMMTPQVITPQQMQQILQQQVLSPQQLQALLQQQQAV 153
Query: 473 VTGERVATSMRTVGKLPRHRPL--SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQL 530
+ ++ + H L + Q Q Q QQ QQQ QQ ++Q+QQQ
Sbjct: 154 MLQQQQLQEFYKKQQEQLHLQLLQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ 213
Query: 531 QLGKILTKTGELPRQPTTHPEETEEELTEQQEVL 564
Q + E +Q + ++L QQ++L
Sbjct: 214 QQQHPGKQAKEQQQQQQQQQQLAAQQLVFQQQLL 247
>gi|21312134 mediator complex subunit 15 isoform b [Homo sapiens]
Length = 748
Score = 63.9 bits (154), Expect = 8e-10
Identities = 102/420 (24%), Positives = 163/420 (38%), Gaps = 73/420 (17%)
Query: 40 PRAMPSSMGGGG--GGSPSPVELRG--------------ALVGSVDP---------TLRE 74
PR S+GG G G P+ L G A+V + P L++
Sbjct: 103 PRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQ 162
Query: 75 QQLQQEL-----LALKQQQQLQKQLLFAEFQ---KQHDHLTRQHEVQLQKHLKQQQEMLA 126
QQ QQ+ AL+QQQQ Q+Q F Q +Q Q + QLQ+ +QQQ ++
Sbjct: 163 QQQQQQFQQQQQAALQQQQQQQQQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIK 222
Query: 127 AKQQQEMLAAKRQQELE-------QQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAI 179
Q + ++QQ+L+ QQ+Q++QQ+Q++ ++Q L+ Q I + +
Sbjct: 223 LHHQNQQQIQQQQQQLQRIAQLQLQQQQQQQQQQQQQQQQALQAQPPI-QQPPMQQPQPP 281
Query: 180 ASTEVKLRLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASL---DQSSPPQSGPPGTP 236
S + +LQ+ ++ +P P PQ P + L Q+ P S P
Sbjct: 282 PSQALPQQLQQMHHTQHHQPPP------QPQQPPVAQNQPSQLPPQSQTQPLVSQAQALP 335
Query: 237 PSYKLPLPGPYDSRDDFPLRKTASEPNLKVRSRLKQKVAERRSSPLLRRKDGTVISTFKK 296
P R +++ +P ++ +Q+ A + + G +S
Sbjct: 336 GQMLYTQPPLKFVRAPMVVQQPPVQPQVQ-----QQQTAVQTAQAAQMVAPGVQVSQSSL 390
Query: 297 RAVEITGAGPGASSVCNSAPGSGPS-SPNSSHSTIAENGFTGSVPNIPTEMLPQHRALPL 355
+ G + + P PS P S N +G P+ P+ LP P
Sbjct: 391 PMLSSPSPGQQVQTPQSMPPPPQPSPQPGQPSSQPNSNVSSGPAPS-PSSFLPSPSPQPS 449
Query: 356 DS-----SPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQ 410
S +P FS+ SP N T N SP S+Q E E+Q L L+Q
Sbjct: 450 QSPVTARTPQNFSV-PSPGPLN---------TPVNPSSVMSPAGSSQAE-EQQYLDKLKQ 498
Score = 35.4 bits (80), Expect = 0.31
Identities = 32/135 (23%), Positives = 52/135 (38%), Gaps = 15/135 (11%)
Query: 466 LHGQSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQ---------ALQQLVMQQ 516
L GQ P T SM V L Q + Q Q ALQQ QQ
Sbjct: 125 LSGQPPPGTSGMAPHSMAVVSTATPQTQLQLQQVALQQQQQQQQFQQQQQAALQQQQQQQ 184
Query: 517 QHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHP------EETEEELTEQQEVLLGEGAL 570
Q QQF +Q Q Q ++ + +L +Q + ++++ +QQ+ L L
Sbjct: 185 QQQQFQAQQSAMQQQFQAVVQQQQQLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQL 244
Query: 571 TMPREGSTESESTQE 585
+ ++ + + Q+
Sbjct: 245 QLQQQQQQQQQQQQQ 259
Score = 33.1 bits (74), Expect = 1.5
Identities = 58/284 (20%), Positives = 97/284 (34%), Gaps = 32/284 (11%)
Query: 298 AVEITGAGPGASSVCNSAPGSGPSSPNSSHSTIAENG----FTGSVPNIPTEMLPQHRAL 353
A++ GP A + P GP ++ G +G P + M P A+
Sbjct: 84 ALQSLTGGPAAGAAGIGMPPRGPGQSLGGMGSLGAMGQPMSLSGQPPPGTSGMAPHSMAV 143
Query: 354 PLDSSPNQFSLYTSPSLPNISLGLQATVTVTNSHLTASPKLSTQQEAERQALQSLRQGGT 413
++P T L ++L Q A+ + QQ+ ++Q Q Q
Sbjct: 144 VSTATPQ-----TQLQLQQVALQQQQQQQQFQQQQQAALQ---QQQQQQQQQQFQAQQSA 195
Query: 414 LTGKFMSTSSIPGCLLGVALEGDGSPHGHASLLQHV---LLLEQARQQSTLIAVPLHGQS 470
+ +F + L+ H L H + +Q +Q + + L Q
Sbjct: 196 MQQQFQAVVQQQQ-----QLQQQQQQQQHLIKLHHQNQQQIQQQQQQLQRIAQLQLQQQQ 250
Query: 471 PLVTGERVATSMRTVGKLP-RHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQ 529
++ + P + P+ + Q P PQ LQQ+ Q HQ + Q+
Sbjct: 251 QQQQQQQQQQQQALQAQPPIQQPPMQQPQPPPSQALPQQLQQMHHTQHHQPPPQPQQPPV 310
Query: 530 LQLGKILTKTGELPRQPTTHPEETEEELTEQQEVLLGEGALTMP 573
Q + +LP Q T P L Q + L G+ T P
Sbjct: 311 AQ-----NQPSQLPPQSQTQP------LVSQAQALPGQMLYTQP 343
>gi|217272877 histone deacetylase 11 isoform 1 [Homo sapiens]
Length = 347
Score = 63.5 bits (153), Expect = 1e-09
Identities = 71/312 (22%), Positives = 128/312 (41%), Gaps = 41/312 (13%)
Query: 700 GNTHVHPEHAGRIQSIWSRLQETGLLSKCERIRGRKATLDEIQTVHSEYHTLLYGTSPLN 759
G +HP AG+ + + L+E LLS + R+A+ +++ VH+ + LN
Sbjct: 30 GLEKLHPFDAGKWGKVINFLKEEKLLSDSMLVEAREASEEDLLVVHTRRY--------LN 81
Query: 760 RQKLDSKKLLGPISQKMYAVLPCGGIGVDSDTVWNEMHSSSAVRMAVGCLLELAFKVAAG 819
K + I++ + V+ V + + MA +E + + G
Sbjct: 82 ELKWSFA--VATITE-IPPVIFLPNFLVQRKVLRPLRTQTGGTIMAGKLAVERGWAINVG 138
Query: 820 ELKNGFAIIRPPGHHAEESTAMGFCFFNSVAITAKLLQQKLN-VGKVLIVDWDIHHGNGT 878
GF HH GFC + + + K L +++ + + I+D D H GNG
Sbjct: 139 ---GGF-------HHCSSDRGGGFCAYADITLAIKFLFERVEGISRATIIDLDAHQGNGH 188
Query: 879 QQAFYNDPSVLYISLHRYDNGNFFPGSGAPEEVGGGPGVGYNVNVAWTGGVDPPIGDVEY 938
++ F +D V + ++ N + +PG ++ + V + W G + D EY
Sbjct: 189 ERDFMDDKRVYIMDVY---NRHIYPGDRFAKQ-----AIRRKVELEW--GTE----DDEY 234
Query: 939 LTAFRTVVMPIAHEFSPDVVLVSAGFDAVEGHLSPLGGYSVTARCFGHLTRQLMTLAGGR 998
L + E PDVV+ +AG D +EG LGG S++ + + GR
Sbjct: 235 LDKVERNIKKSLQEHLPDVVVYNAGTDILEG--DRLGGLSISPAGIVKRDELVFRMVRGR 292
Query: 999 ---VVLALEGGH 1007
+++ GG+
Sbjct: 293 RVPILMVTSGGY 304
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 62.8 bits (151), Expect = 2e-09
Identities = 66/266 (24%), Positives = 118/266 (44%), Gaps = 42/266 (15%)
Query: 13 GREPSLEILPRTSLHSIPV--TVEVKPVLPRA---MPSSMGGGGGGSPSPVELRGALVGS 67
G + + +H++ V + E P LPR +P+ + G ++ R
Sbjct: 92 GSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQ 151
Query: 68 VDPTLREQQLQQELLALK------------QQQQLQKQLLFAEFQKQH--DHLTRQHEVQ 113
L ++L++E + + ++++L+++ L E Q++ + L RQ ++
Sbjct: 152 RQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLE 211
Query: 114 LQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEK 173
Q+ L++Q+ + +++QE +R + LE++RQ E++RQE+LE+++LE + R +
Sbjct: 212 RQERLERQERL--DRERQERQERERLERLERERQ-ERERQEQLEREQLEWE----RERRI 264
Query: 174 SKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLP-QHPKCWGAHHASLDQSSPPQ--- 229
S +A AS E L +L S PG S P + P G L PP
Sbjct: 265 SSAAAPASVETPLNS---VLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPP 321
Query: 230 ---------SGPPGTPPSYKLPLPGP 246
PPG PP LP GP
Sbjct: 322 GPAQASVALPPPPGPPPPPPLPSTGP 347
Score = 39.3 bits (90), Expect = 0.021
Identities = 58/242 (23%), Positives = 99/242 (40%), Gaps = 34/242 (14%)
Query: 470 SPLVTGERVATSMRTVGKLPRHRPL--SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQK- 526
S ++ V S T LPR ++ Q+ P + + ++ + +QQ Q+ LE+++
Sbjct: 102 SAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERL 161
Query: 527 ----------------QQQLQLGKILTKTGELPRQPTTHPEETE-EELTEQQEVLLGEGA 569
+++L+ ++ + E RQ E E +E E+QE L +
Sbjct: 162 ERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQER 221
Query: 570 LTMPREGSTESESTQEDLEEEDEEDDGEE--EEDCIQVKDEEGESGAEEGPDLEEP---- 623
L R+ E E E LE E +E + +E E + ++ + E S A +E P
Sbjct: 222 LDRERQERQERERL-ERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSV 280
Query: 624 ----GAGYKKLFSDAQPLQ-PLQ--VYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQ 676
A L + +QP + P Q + PL+ P G Q+S A P PP
Sbjct: 281 LGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPP 340
Query: 677 PV 678
P+
Sbjct: 341 PL 342
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 62.8 bits (151), Expect = 2e-09
Identities = 66/266 (24%), Positives = 118/266 (44%), Gaps = 42/266 (15%)
Query: 13 GREPSLEILPRTSLHSIPV--TVEVKPVLPRA---MPSSMGGGGGGSPSPVELRGALVGS 67
G + + +H++ V + E P LPR +P+ + G ++ R
Sbjct: 92 GSKEDANVFASAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQ 151
Query: 68 VDPTLREQQLQQELLALK------------QQQQLQKQLLFAEFQKQH--DHLTRQHEVQ 113
L ++L++E + + ++++L+++ L E Q++ + L RQ ++
Sbjct: 152 RQKELERERLERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLE 211
Query: 114 LQKHLKQQQEMLAAKQQQEMLAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEK 173
Q+ L++Q+ + +++QE +R + LE++RQ E++RQE+LE+++LE + R +
Sbjct: 212 RQERLERQERL--DRERQERQERERLERLERERQ-ERERQEQLEREQLEWE----RERRI 264
Query: 174 SKESAIASTEVKLRLQEFLLSKSKEPTPGGLNHSLP-QHPKCWGAHHASLDQSSPPQ--- 229
S +A AS E L +L S PG S P + P G L PP
Sbjct: 265 SSAAAPASVETPLNS---VLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPP 321
Query: 230 ---------SGPPGTPPSYKLPLPGP 246
PPG PP LP GP
Sbjct: 322 GPAQASVALPPPPGPPPPPPLPSTGP 347
Score = 39.3 bits (90), Expect = 0.021
Identities = 58/242 (23%), Positives = 99/242 (40%), Gaps = 34/242 (14%)
Query: 470 SPLVTGERVATSMRTVGKLPRHRPL--SRTQSSPLPQSPQALQQLVMQQQHQQFLEKQK- 526
S ++ V S T LPR ++ Q+ P + + ++ + +QQ Q+ LE+++
Sbjct: 102 SAMMHALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERL 161
Query: 527 ----------------QQQLQLGKILTKTGELPRQPTTHPEETE-EELTEQQEVLLGEGA 569
+++L+ ++ + E RQ E E +E E+QE L +
Sbjct: 162 ERERMERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQER 221
Query: 570 LTMPREGSTESESTQEDLEEEDEEDDGEE--EEDCIQVKDEEGESGAEEGPDLEEP---- 623
L R+ E E E LE E +E + +E E + ++ + E S A +E P
Sbjct: 222 LDRERQERQERERL-ERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLNSV 280
Query: 624 ----GAGYKKLFSDAQPLQ-PLQ--VYQAPLSLATVPHQALGRTQSSPAAPGGMKSPPDQ 676
A L + +QP + P Q + PL+ P G Q+S A P PP
Sbjct: 281 LGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPPPPPLPPGPAQASVALPPPPGPPPPP 340
Query: 677 PV 678
P+
Sbjct: 341 PL 342
>gi|33286444 mastermind-like 2 [Homo sapiens]
Length = 1156
Score = 62.8 bits (151), Expect = 2e-09
Identities = 44/166 (26%), Positives = 90/166 (54%), Gaps = 11/166 (6%)
Query: 70 PTLREQQLQQELLALKQQQQLQKQLLFAEFQKQHDHLTRQHEVQLQKHLKQQQEMLAAKQ 129
P++ Q + LL QQQQ Q+Q + Q+Q +Q + Q Q+ +QQQ ++A+Q
Sbjct: 572 PSVLPSQNKPSLLHYTQQQQQQQQ---QQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQ 628
Query: 130 QQEM---LAAKRQQELEQQRQREQQRQEELEKQRLEQQLLILRNKEKSKESAIASTEVKL 186
QQ+ ++A++QQ+ +QQ+Q++QQ+Q++ ++Q +QQ + + + + + L
Sbjct: 629 QQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQ--QQQQPSSQPAQSLPSQPLLRSPLPL 686
Query: 187 RLQEFLLSKSKEPTPGGLNHSLPQHPKCWGAHHASLDQSSPPQSGP 232
+ Q+ LL + + G+ + + Q + H+ + Q++ P P
Sbjct: 687 Q-QKLLLQQMQNQPIAGMGYQVSQQQR--QDQHSVVGQNTGPSPSP 729
Score = 35.8 bits (81), Expect = 0.23
Identities = 32/175 (18%), Positives = 62/175 (35%), Gaps = 17/175 (9%)
Query: 501 PLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEELTEQ 560
P P L QQQ QQ +Q+QQQ Q +Q ++ +++ +Q
Sbjct: 576 PSQNKPSLLHYTQQQQQQQQ---QQQQQQQQ------------QQQQQQQQQQQQQQQQQ 620
Query: 561 QEVLLGEGALTMPREGSTESESTQEDLEEEDEEDDGEEEEDCIQVKDEEGESGAEEGPDL 620
Q + + S + + Q+ +++ ++ ++++ Q + P L
Sbjct: 621 QSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQQQPSSQPAQSLPSQPLL 680
Query: 621 EEPGAGYKKLFSDAQPLQPL--QVYQAPLSLATVPHQALGRTQSSPAAPGGMKSP 673
P +KL QP+ YQ H +G+ +P +P
Sbjct: 681 RSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGPSPSPNPCSNP 735
Score = 33.5 bits (75), Expect = 1.2
Identities = 25/84 (29%), Positives = 37/84 (44%), Gaps = 8/84 (9%)
Query: 489 PRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQ-------FLEKQKQQQLQLGKILTKTGE 541
P +P S PL +SP LQQ ++ QQ Q + Q+Q+Q Q + TG
Sbjct: 666 PSSQPAQSLPSQPLLRSPLPLQQKLLLQQMQNQPIAGMGYQVSQQQRQDQHSVVGQNTGP 725
Query: 542 LPR-QPTTHPEETEEELTEQQEVL 564
P P ++P + QQ +L
Sbjct: 726 SPSPNPCSNPNTGSGYMNSQQSLL 749
Score = 32.3 bits (72), Expect = 2.6
Identities = 19/78 (24%), Positives = 35/78 (44%)
Query: 498 QSSPLPQSPQALQQLVMQQQHQQFLEKQKQQQLQLGKILTKTGELPRQPTTHPEETEEEL 557
Q Q Q QQ QQQ Q + Q+QQQ Q + + +Q ++ +++
Sbjct: 600 QQQQQQQQQQQQQQQQQQQQQQSSISAQQQQQQQSSISAQQQQQQQQQQQQQQQQQQQQQ 659
Query: 558 TEQQEVLLGEGALTMPRE 575
+QQ+ + A ++P +
Sbjct: 660 QQQQQQPSSQPAQSLPSQ 677
Score = 31.6 bits (70), Expect = 4.4
Identities = 22/94 (23%), Positives = 39/94 (41%)
Query: 469 QSPLVTGERVATSMRTVGKLPRHRPLSRTQSSPLPQSPQALQQLVMQQQHQQFLEKQKQQ 528
Q P V + S+ + + + + Q Q Q QQ QQQ QQ +QQ
Sbjct: 570 QMPSVLPSQNKPSLLHYTQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQSSISAQQQ 629
Query: 529 QLQLGKILTKTGELPRQPTTHPEETEEELTEQQE 562
Q Q I + + +Q ++ +++ +QQ+
Sbjct: 630 QQQQSSISAQQQQQQQQQQQQQQQQQQQQQQQQQ 663
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.129 0.371
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 49,355,704
Number of Sequences: 37866
Number of extensions: 2737291
Number of successful extensions: 45575
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 717
Number of HSP's successfully gapped in prelim test: 1089
Number of HSP's that attempted gapping in prelim test: 17385
Number of HSP's gapped (non-prelim): 13771
length of query: 1123
length of database: 18,247,518
effective HSP length: 113
effective length of query: 1010
effective length of database: 13,968,660
effective search space: 14108346600
effective search space used: 14108346600
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.