BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|61966761 leucine rich repeat containing 26 [Homo sapiens] (334 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|61966761 leucine rich repeat containing 26 [Homo sapiens] 679 0.0 gi|52353306 leucine rich repeat containing 55 [Homo sapiens] 126 3e-29 gi|239752702 PREDICTED: leucine rich repeat containing 38, parti... 123 2e-28 gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo ... 122 6e-28 gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo ... 122 6e-28 gi|188528675 slit homolog 1 [Homo sapiens] 120 2e-27 gi|229089140 leucine rich repeat containing 24 [Homo sapiens] 116 2e-26 gi|194306623 immunoglobulin superfamily containing leucine-rich ... 115 7e-26 gi|194306621 immunoglobulin superfamily containing leucine-rich ... 115 7e-26 gi|39930401 immunoglobulin superfamily containing leucine-rich r... 115 7e-26 gi|194306618 immunoglobulin superfamily containing leucine-rich ... 115 7e-26 gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho... 109 4e-24 gi|11321571 slit homolog 3 [Homo sapiens] 106 3e-23 gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] 106 3e-23 gi|4759146 slit homolog 2 [Homo sapiens] 105 6e-23 gi|194440719 chondroadherin-like [Homo sapiens] 103 3e-22 gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 102 5e-22 gi|41582239 immunoglobulin superfamily containing leucine-rich r... 101 1e-21 gi|5031809 immunoglobulin superfamily containing leucine-rich re... 101 1e-21 gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens] 98 9e-21 gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens] 98 9e-21 gi|225579152 insulin-like growth factor binding protein, acid la... 97 2e-20 gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 97 2e-20 gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 97 3e-20 gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho... 97 3e-20 gi|194018474 leucine rich repeat containing 52 [Homo sapiens] 96 4e-20 gi|4826772 insulin-like growth factor binding protein, acid labi... 95 8e-20 gi|88702793 slit-like 2 [Homo sapiens] 95 8e-20 gi|4758460 glycoprotein V (platelet) [Homo sapiens] 93 4e-19 gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 93 4e-19 >gi|61966761 leucine rich repeat containing 26 [Homo sapiens] Length = 334 Score = 679 bits (1751), Expect = 0.0 Identities = 334/334 (100%), Positives = 334/334 (100%) Query: 1 MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSAL 60 MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSAL Sbjct: 1 MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSAL 60 Query: 61 SLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGA 120 SLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGA Sbjct: 61 SLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGA 120 Query: 121 LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELA 180 LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELA Sbjct: 121 LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELA 180 Query: 181 ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240 ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS Sbjct: 181 ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240 Query: 241 PLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTA 300 PLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTA Sbjct: 241 PLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTA 300 Query: 301 ALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA 334 ALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA Sbjct: 301 ALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA 334 >gi|52353306 leucine rich repeat containing 55 [Homo sapiens] Length = 341 Score = 126 bits (316), Expect = 3e-29 Identities = 95/296 (32%), Positives = 131/296 (44%), Gaps = 19/296 (6%) Query: 3 GPSWSR------PRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLAS 56 G +W++ P P +LL+ LL A S CP +CTC + Sbjct: 45 GDTWAQLPWPGPPHPAMLLISLL----------LAAGLMHSDAGTSCPVLCTC-RNQVVD 93 Query: 57 CSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFW 116 CS+ L +VPP L + R L L HNR+ A+PPG LQ LDL N L + F Sbjct: 94 CSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFL 153 Query: 117 GLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNR-LARLEPAALGALPLLRSLSLQ 175 L LDLS N + F L ++ L+ N L R+ P A L LR L L Sbjct: 154 HAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLS 213 Query: 176 DNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLR-RHPLPASEAETVLCVWP 234 LA L+ L LP L L + GNPW CGC + PL WLR R ++++ C P Sbjct: 214 YGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGP 273 Query: 235 GRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTAC 290 + +PL + ++ +F C L L D + +G + S+A+ LG C Sbjct: 274 PEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCC 329 >gi|239752702 PREDICTED: leucine rich repeat containing 38, partial [Homo sapiens] Length = 254 Score = 123 bits (309), Expect = 2e-28 Identities = 82/231 (35%), Positives = 109/231 (47%), Gaps = 3/231 (1%) Query: 57 CSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFW 116 C LP+VP L +R LL+ NR++ +P F G L LD R N L S+ F Sbjct: 2 CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61 Query: 117 GLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQD 176 G L LDLS N L L G F L LSLA N L + A L L+ L L D Sbjct: 62 GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELND 121 Query: 177 NELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH--PLPASEAETVLCVWP 234 N L +L+ L LPAL +L L GNPW C C L +W++ + LP + + C P Sbjct: 122 NNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKG-LDEIQCSLP 180 Query: 235 GRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGS 285 L S+A+FS C L+L DL ++ G A + ++ S L + Sbjct: 181 MESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLAT 231 >gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo sapiens] Length = 408 Score = 122 bits (305), Expect = 6e-28 Identities = 81/226 (35%), Positives = 108/226 (47%), Gaps = 3/226 (1%) Query: 62 LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121 LP+VP L +R LL+ NR++ +P F G L LD R N L S+ F G L Sbjct: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220 Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAA 181 LDLS N L L G F L LSLA N L + A L L+ L L DN L + Sbjct: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280 Query: 182 LAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH--PLPASEAETVLCVWPGRLTL 239 L+ L LPAL +L L GNPW C C L +W++ + LP + + C P Sbjct: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKG-LDEIQCSLPMESRR 339 Query: 240 SPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGS 285 L S+A+FS C L+L DL ++ G A + ++ S L + Sbjct: 340 ISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLAT 385 >gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo sapiens] Length = 408 Score = 122 bits (305), Expect = 6e-28 Identities = 81/226 (35%), Positives = 108/226 (47%), Gaps = 3/226 (1%) Query: 62 LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121 LP+VP L +R LL+ NR++ +P F G L LD R N L S+ F G L Sbjct: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220 Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAA 181 LDLS N L L G F L LSLA N L + A L L+ L L DN L + Sbjct: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280 Query: 182 LAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH--PLPASEAETVLCVWPGRLTL 239 L+ L LPAL +L L GNPW C C L +W++ + LP + + C P Sbjct: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKG-LDEIQCSLPMESRR 339 Query: 240 SPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGS 285 L S+A+FS C L+L DL ++ G A + ++ S L + Sbjct: 340 ISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLAT 385 >gi|188528675 slit homolog 1 [Homo sapiens] Length = 1534 Score = 120 bits (301), Expect = 2e-27 Identities = 75/211 (35%), Positives = 109/211 (51%), Gaps = 4/211 (1%) Query: 27 QVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRAL 86 Q A P+ +L + CP +CTC G+ C L A+P L + + L+ N ++++ Sbjct: 266 QGEAGRVPTCTLSSGSCPAMCTC-SNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSI 324 Query: 87 PPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALR 146 PPGAF+ L+R+DL N + + AF GL +L L L N++ L G F L L+ Sbjct: 325 PPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQ 384 Query: 147 NLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCG 206 L L N++ + P A L L LSL DN++ +LA G L A+ LHL NP+ C Sbjct: 385 LLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICD 444 Query: 207 CALRPLCAWLRRHPLPASEAETVLCVWPGRL 237 C L+ L +LR +P+ S A C P RL Sbjct: 445 CNLKWLADFLRTNPIETSGAR---CASPRRL 472 Score = 102 bits (253), Expect = 6e-22 Identities = 67/208 (32%), Positives = 99/208 (47%), Gaps = 7/208 (3%) Query: 43 CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPP-GAFAGAGALQRLD 101 CP C C + CS+L L +P + L L++N + L G F L++++ Sbjct: 513 CPHKCRC-EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571 Query: 102 LRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPA 161 L N + + AF G ++ L L+ANQLE++ G F L LR L L NR++ + Sbjct: 572 LSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHND 631 Query: 162 ALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPL 221 + L +R LSL DN++ ++PG L +L L+L NP+ C C L L WLR+ + Sbjct: 632 SFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKI 691 Query: 222 PASEAETVLCVWPGRLTLSPL--TAFSD 247 C P L PL AF D Sbjct: 692 VTGNPR---CQNPDFLRQIPLQDVAFPD 716 Score = 94.4 bits (233), Expect = 1e-19 Identities = 91/316 (28%), Positives = 119/316 (37%), Gaps = 44/316 (13%) Query: 3 GPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSL 62 G S RP L LLL + W LGA CP +CTC G C L Sbjct: 8 GSSAGPVRPELWLLLWAAAW--------------RLGASACPALCTCT-GTTVDCHGTGL 52 Query: 63 PAVPPGLSL------------------------RLRALLLDHNRVRALPPGAFAGAGALQ 98 A+P + +LR L L N++ A+ GAF L+ Sbjct: 53 QAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELE 112 Query: 99 RLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARL 158 RL L N LH + F AL LDLS N ++A+ F L+NL L N+++ + Sbjct: 113 RLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCI 172 Query: 159 EPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR 218 E A AL L L+L +N + + +P L L N C C L L WLR+ Sbjct: 173 EEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ 232 Query: 219 HPLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLG--PASFLVS 276 P + C P L + + FS Q A R + G PA S Sbjct: 233 RPTIGLFTQ---CSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCS 289 Query: 277 LASCLALGSGLTACRA 292 G GLTA A Sbjct: 290 NGIVDCRGKGLTAIPA 305 Score = 79.0 bits (193), Expect = 6e-15 Identities = 55/182 (30%), Positives = 82/182 (45%), Gaps = 26/182 (14%) Query: 36 GSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAG 95 G L P CP+ C C+ + CS L A+P G+ + L LD N+ +P G Sbjct: 727 GCLPRPQCPQECACLDT-VVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVP-------G 778 Query: 96 ALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRL 155 L LQL+DLS N++ +L+ +F + L L L+ N L Sbjct: 779 QLSTFKY------------------LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820 Query: 156 ARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAW 215 + P A L LR LSL N+++ L G+ + +L L + NP C C LR L +W Sbjct: 821 QCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSW 880 Query: 216 LR 217 ++ Sbjct: 881 VK 882 >gi|229089140 leucine rich repeat containing 24 [Homo sapiens] Length = 513 Score = 116 bits (291), Expect = 2e-26 Identities = 95/288 (32%), Positives = 119/288 (41%), Gaps = 43/288 (14%) Query: 8 RPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPP 67 R LL LLLLL P L A CP C C C AL L VP Sbjct: 4 RAPALLPLLLLLLP----------------LRAAGCPAACRCY-SATVECGALRLRVVPL 46 Query: 68 GLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS 127 G+ + L L N + L PGA A AL+RL L N L ++ AF L L L+ Sbjct: 47 GIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALT 106 Query: 128 ANQLEALAPGTFAPLRALRNLSLAGNRLARL------------------------EPAAL 163 +N+L L G F L LR L LAGN+LARL E AL Sbjct: 107 SNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQAL 166 Query: 164 GALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR--HPL 221 L L L L N+L ++ L L +L L L NPW C CAL L AW++ L Sbjct: 167 AGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRL 226 Query: 222 PASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLG 269 S ++C P RL L L S ++ + ++ L + LG Sbjct: 227 LTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPLELTANLG 274 >gi|194306623 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 115 bits (287), Expect = 7e-26 Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 12/224 (5%) Query: 22 WPVWAQVSATASPSGSLGAPDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLL 78 W VWA + S CPE C CV A C+ L VP GL + L L Sbjct: 8 WLVWALLGVAGS---------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSL 58 Query: 79 DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138 N++ L GAFA + L L N + +V A L L+ LDLS N + + Sbjct: 59 SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118 Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198 L AL+ L + NRL L ALGALP LRSL + +N L LAPG L AL L L Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178 Query: 199 RGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242 NP+ CGC L L AW + E +++ C P L P+ Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV 222 >gi|194306621 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 115 bits (287), Expect = 7e-26 Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 12/224 (5%) Query: 22 WPVWAQVSATASPSGSLGAPDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLL 78 W VWA + S CPE C CV A C+ L VP GL + L L Sbjct: 8 WLVWALLGVAGS---------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSL 58 Query: 79 DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138 N++ L GAFA + L L N + +V A L L+ LDLS N + + Sbjct: 59 SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118 Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198 L AL+ L + NRL L ALGALP LRSL + +N L LAPG L AL L L Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178 Query: 199 RGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242 NP+ CGC L L AW + E +++ C P L P+ Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV 222 >gi|39930401 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 115 bits (287), Expect = 7e-26 Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 12/224 (5%) Query: 22 WPVWAQVSATASPSGSLGAPDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLL 78 W VWA + S CPE C CV A C+ L VP GL + L L Sbjct: 8 WLVWALLGVAGS---------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSL 58 Query: 79 DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138 N++ L GAFA + L L N + +V A L L+ LDLS N + + Sbjct: 59 SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118 Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198 L AL+ L + NRL L ALGALP LRSL + +N L LAPG L AL L L Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178 Query: 199 RGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242 NP+ CGC L L AW + E +++ C P L P+ Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV 222 >gi|194306618 immunoglobulin superfamily containing leucine-rich repeat 2 [Homo sapiens] Length = 745 Score = 115 bits (287), Expect = 7e-26 Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 12/224 (5%) Query: 22 WPVWAQVSATASPSGSLGAPDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLL 78 W VWA + S CPE C CV A C+ L VP GL + L L Sbjct: 8 WLVWALLGVAGS---------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSL 58 Query: 79 DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138 N++ L GAFA + L L N + +V A L L+ LDLS N + + Sbjct: 59 SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118 Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198 L AL+ L + NRL L ALGALP LRSL + +N L LAPG L AL L L Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178 Query: 199 RGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242 NP+ CGC L L AW + E +++ C P L P+ Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV 222 >gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo sapiens] Length = 370 Score = 109 bits (272), Expect = 4e-24 Identities = 75/216 (34%), Positives = 94/216 (43%), Gaps = 1/216 (0%) Query: 41 PDCPEVCTCVPGGL-ASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQR 99 P CP C C L CS L L VPP + R LLL +N++ ALP AFA +LQR Sbjct: 37 PTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQR 96 Query: 100 LDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLE 159 LDL N L + F L L L L N + L LR+L L+ N LA+L Sbjct: 97 LDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP 156 Query: 160 PAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH 219 P L LRSLSL+ N L L L L L + NPW C C LR W+ Sbjct: 157 PGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWF 216 Query: 220 PLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQ 255 + + C P L + F++C+Q Sbjct: 217 SYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQ 252 >gi|11321571 slit homolog 3 [Homo sapiens] Length = 1523 Score = 106 bits (265), Expect = 3e-23 Identities = 68/217 (31%), Positives = 105/217 (48%), Gaps = 4/217 (1%) Query: 34 PSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAG 93 PS + + CP CTC + C L +P L + + L+ N ++A+P GAF Sbjct: 271 PSCNANSISCPSPCTC-SNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQ 329 Query: 94 AGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGN 153 L+R+D+ +N + + AF GL +L L L N++ +A G F L +L+ L L N Sbjct: 330 YKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNAN 389 Query: 154 RLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLC 213 ++ L L L LSL DN+L ++ GL L ++ LHL NP+ C C L+ L Sbjct: 390 KINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLA 449 Query: 214 AWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAF 250 +L+ +P+ S A C P RL ++ F Sbjct: 450 DYLQDNPIETSGAR---CSSPRRLANKRISQIKSKKF 483 Score = 91.7 bits (226), Expect = 8e-19 Identities = 59/177 (33%), Positives = 83/177 (46%), Gaps = 2/177 (1%) Query: 43 CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPP-GAFAGAGALQRLD 101 CPE C C G + CS L +P L + L L+ N V L G F L++++ Sbjct: 505 CPEKCRC-EGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKIN 563 Query: 102 LRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPA 161 L N + V AF G ++Q L L+ NQLE + F L L+ L L N + + Sbjct: 564 LSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSND 623 Query: 162 ALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR 218 L +R LSL DN + + PG L +L ++L NP+ C C L L WLR+ Sbjct: 624 TFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK 680 Score = 83.6 bits (205), Expect = 2e-16 Identities = 67/232 (28%), Positives = 95/232 (40%), Gaps = 28/232 (12%) Query: 30 ATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLR----------------- 72 A AS A CP CTC + C L L AVP G+ Sbjct: 21 ALASVLSGPPAVACPTKCTCSAASV-DCHGLGLRAVPRGIPRNAERLDLDRNNITRITKM 79 Query: 73 -------LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLD 125 LR L L+ N+V + GAF L+RL L +N L + F L LD Sbjct: 80 DFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLD 139 Query: 126 LSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPG 185 LS NQ++ + F + ++NL L N ++ +E A AL L L+L +N ++ + Sbjct: 140 LSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVT 199 Query: 186 LLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRL 237 +P + L L N C C L L WLR+ + + LC+ P L Sbjct: 200 SFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR---RTVGQFTLCMAPVHL 248 Score = 76.3 bits (186), Expect = 4e-14 Identities = 55/178 (30%), Positives = 80/178 (44%), Gaps = 26/178 (14%) Query: 40 APDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQR 99 +P CPE CTC+ + CS L A+P G+ + L L+ N + A+P Sbjct: 722 SPRCPEQCTCMET-VVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVP------------ 768 Query: 100 LDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLE 159 R L L L+DLS N + L TF+ + L L L+ NRL + Sbjct: 769 -------------RELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIP 815 Query: 160 PAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLR 217 A L LR L+L N+++++ G L +L L L NP C C+LR L W++ Sbjct: 816 VHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK 873 >gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens] Length = 2623 Score = 106 bits (265), Expect = 3e-23 Identities = 80/273 (29%), Positives = 119/273 (43%), Gaps = 46/273 (16%) Query: 25 WAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVR 84 +A + A+P G CP C C C+ L ++P + + + L +N + Sbjct: 15 FAVICLVATPGGKA----CPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLV 70 Query: 85 ALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRA 144 L F+G L+ L L NG+H++ + F L ALQ+L +S N++ L TF LR+ Sbjct: 71 RLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRS 130 Query: 145 LRNLS------------------------LAGNRLARLEPAALGALPLL--------RSL 172 L L L GN+L +L P +L L + L Sbjct: 131 LTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFL 190 Query: 173 SLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHP---------LPA 223 L DN L +L ++ +P LD+L+L GNPW C C L+ L W++ P P+ Sbjct: 191 YLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPS 250 Query: 224 SEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQP 256 S + LC+ P PL S AAF CA+P Sbjct: 251 SAQQCPLCMNPRTSKGKPLAMVSAAAF-QCAKP 282 >gi|4759146 slit homolog 2 [Homo sapiens] Length = 1529 Score = 105 bits (262), Expect = 6e-23 Identities = 66/195 (33%), Positives = 95/195 (48%), Gaps = 4/195 (2%) Query: 43 CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDL 102 CP CTC + C L +P L + + L+ N ++ +PPGAF+ L+R+DL Sbjct: 273 CPAACTC-SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDL 331 Query: 103 RENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAA 162 N + + AF GL +L L L N++ L F L +L+ L L N++ L A Sbjct: 332 SNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDA 391 Query: 163 LGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLP 222 L L LSL DN+L +A G L A+ +HL NP+ C C L+ L +L +P+ Sbjct: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIE 451 Query: 223 ASEAETVLCVWPGRL 237 S A C P RL Sbjct: 452 TSGAR---CTSPRRL 463 Score = 86.3 bits (212), Expect = 4e-17 Identities = 55/177 (31%), Positives = 84/177 (47%), Gaps = 2/177 (1%) Query: 43 CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPP-GAFAGAGALQRLD 101 CPE C C G CS L +P + L L++N L G F L++++ Sbjct: 506 CPEKCRC-EGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKIN 564 Query: 102 LRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPA 161 N + + AF G + + L++N+LE + F L +L+ L L NR+ + Sbjct: 565 FSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGND 624 Query: 162 ALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR 218 + L +R LSL DN++ +APG L +L L+L NP+ C C L L WLR+ Sbjct: 625 SFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRK 681 Score = 83.6 bits (205), Expect = 2e-16 Identities = 62/202 (30%), Positives = 85/202 (42%), Gaps = 25/202 (12%) Query: 43 CPEVCTCVPGGLASCSALSLPAVPPGL-----------------------SLR-LRALLL 78 CP C+C G C L+L +VP + LR LR L L Sbjct: 28 CPAQCSC-SGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQL 86 Query: 79 DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138 N++ + GAF L+RL L N L F G L LDLS NQ++A+ Sbjct: 87 MENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKA 146 Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198 F ++NL L N+++ +E A AL L L+L +N + L+ +P L L Sbjct: 147 FRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRL 206 Query: 199 RGNPWGCGCALRPLCAWLRRHP 220 N C C L L WLR+ P Sbjct: 207 HSNNLYCDCHLAWLSDWLRQRP 228 Score = 67.4 bits (163), Expect = 2e-11 Identities = 59/221 (26%), Positives = 90/221 (40%), Gaps = 30/221 (13%) Query: 43 CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDL 102 CP CTC+ + CS L +P G+ + L LD N+ L P + L +DL Sbjct: 727 CPTECTCLDT-VVRCSNKGLKVLPKGIPRDVTELYLDGNQF-TLVPKELSNYKHLTLIDL 784 Query: 103 RENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAA 162 N + ++ ++F + L L LS N+L + P TF L++LR LSL G Sbjct: 785 SNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHG---------- 834 Query: 163 LGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLP 222 N+++ + G L AL L + NP C C ++ L W++ Sbjct: 835 --------------NDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE--- 877 Query: 223 ASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLA 263 E C PG + L F+ C P+ + LA Sbjct: 878 YKEPGIARCAGPGEMADKLLLTTPSKKFT-CQGPVDVNILA 917 >gi|194440719 chondroadherin-like [Homo sapiens] Length = 762 Score = 103 bits (256), Expect = 3e-22 Identities = 93/282 (32%), Positives = 122/282 (43%), Gaps = 17/282 (6%) Query: 34 PSGSLGAPDCPEVCTCVPGGL-ASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFA 92 P CP C CVP +SC L AVP G + L L N ++P AF Sbjct: 387 PGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFP 446 Query: 93 GAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAG 152 G G L L L+ G+ + A GLG L L LS NQL L+ L L L Sbjct: 447 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLER 506 Query: 153 NRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN---PWGCGCAL 209 NR ++ AAL ALP L SL LQDN + LAPG LGR AL ++L GN G AL Sbjct: 507 NRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLG-AL 565 Query: 210 RPLCAWLRRH-------PLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDL 262 P + H +P E + + +L+ +PL A D AF QP+ R L Sbjct: 566 GPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAF----QPVG-RSL 620 Query: 263 AVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTAALRP 304 ++ + + LG GL + ++ +LR P Sbjct: 621 QHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALP 662 Score = 93.2 bits (230), Expect = 3e-19 Identities = 97/288 (33%), Positives = 118/288 (40%), Gaps = 46/288 (15%) Query: 1 MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGL-ASCSA 59 M GP S PL+L LL+L +P+ A CP+ C C +C Sbjct: 1 MEGPRSSTHVPLVLPLLVL----------LLLAPARQAAAQRCPQACICDNSRRHVACRY 50 Query: 60 LSLPAVP---PGLSLRLRA---------------------LLLDHNRVRALPPGAFAGAG 95 +L VP P L+ RL L L H V + GAF G G Sbjct: 51 QNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLG 110 Query: 96 ALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRL 155 L L+L N L + A GLG+L+ L+L N LE L PGTF L AL L+LA N L Sbjct: 111 RLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNAL 170 Query: 156 ARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN-----PWGCGCALR 210 L A L +R L L N L+ LAP L LPAL L L N P R Sbjct: 171 VYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQAR 230 Query: 211 PLCAW-LRRHPLPASEAETVLCVWPGRLTL----SPLTAFSDAAFSHC 253 L L +PL + E L + PG L L A AF+HC Sbjct: 231 GLARLELGHNPLTYAGEEDGLAL-PGLRELLLDGGALQALGPRAFAHC 277 Score = 85.9 bits (211), Expect = 5e-17 Identities = 70/191 (36%), Positives = 85/191 (44%), Gaps = 6/191 (3%) Query: 54 LASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVR 113 LA + + LPA+ LR+R L L HN + L P A AG AL+RL L N L ++ Sbjct: 165 LAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGP 224 Query: 114 AFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLS 173 L L+L N L L LR L L G L L P A P L +L Sbjct: 225 VLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLD 284 Query: 174 LQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVW 233 L+ N+L L P L L L L+GNP CGC RPL WL R + + A C Sbjct: 285 LRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGA----CQG 338 Query: 234 PGRLTLSPLTA 244 P RL L A Sbjct: 339 PRRLRGEALDA 349 Score = 84.0 bits (206), Expect = 2e-16 Identities = 61/151 (40%), Positives = 79/151 (52%), Gaps = 4/151 (2%) Query: 68 GLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS 127 G + LR + L NR+ + GA A L++L L N L V A GL AL L LS Sbjct: 542 GRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLS 601 Query: 128 ANQLEALAPGTFAPL-RALRNLSLAGNRLARLEPAALGAL-PLLRSLSLQDNELAALAPG 185 N L AL G F P+ R+L++L L + L ++ P A L P L+SL LQ N+L AL Sbjct: 602 GNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA- 660 Query: 186 LLGRLPALDALHLRGNPWGCGCALRPLCAWL 216 L L L+ + L NP+ C C L PL WL Sbjct: 661 -LPSLSQLELIDLSSNPFHCDCQLLPLHRWL 690 >gi|76880480 hypothetical protein LOC9865 [Homo sapiens] Length = 811 Score = 102 bits (254), Expect = 5e-22 Identities = 61/144 (42%), Positives = 77/144 (53%) Query: 73 LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132 L +L+L N ++ L P F L L LR N L + AFWGL AL+ L L N+L Sbjct: 231 LSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLS 290 Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192 L PL +L L L+GN L+ L PA G L LR LSL++N L+AL+ + PA Sbjct: 291 QLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPA 350 Query: 193 LDALHLRGNPWGCGCALRPLCAWL 216 L L L GN W C C LR L W+ Sbjct: 351 LYRLDLDGNGWTCDCRLRGLKRWM 374 Score = 86.7 bits (213), Expect = 3e-17 Identities = 63/168 (37%), Positives = 78/168 (46%), Gaps = 4/168 (2%) Query: 38 LGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLR----LRALLLDHNRVRALPPGAFAG 93 L P CPE C C C+ L VP SL + L N + + F Sbjct: 22 LAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHR 81 Query: 94 AGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGN 153 G L+RLDL+ N + S+H + F L L+ L L N L+ALAPGT APLR LR L GN Sbjct: 82 LGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGN 141 Query: 154 RLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201 ++RL + L L L L N L AL + L L LHL N Sbjct: 142 EISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESN 189 >gi|41582239 immunoglobulin superfamily containing leucine-rich repeat [Homo sapiens] Length = 428 Score = 101 bits (251), Expect = 1e-21 Identities = 71/207 (34%), Positives = 92/207 (44%), Gaps = 3/207 (1%) Query: 40 APDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGA 96 A CPE C C +A C+ L +VPPG + L L NR+ LP GAF Sbjct: 16 AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPL 75 Query: 97 LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLA 156 LQ L L N + +V A L L+ LDLS N + A L AL+ L + N L Sbjct: 76 LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELT 135 Query: 157 RLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWL 216 + A +L LRSL L N L LA G L AL L + NP+ C C + L W Sbjct: 136 FIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWA 195 Query: 217 RRHPLPASEAETVLCVWPGRLTLSPLT 243 + E + + C P L +PL+ Sbjct: 196 LTTAVSIPEQDNIACTSPHVLKGTPLS 222 >gi|5031809 immunoglobulin superfamily containing leucine-rich repeat [Homo sapiens] Length = 428 Score = 101 bits (251), Expect = 1e-21 Identities = 71/207 (34%), Positives = 92/207 (44%), Gaps = 3/207 (1%) Query: 40 APDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGA 96 A CPE C C +A C+ L +VPPG + L L NR+ LP GAF Sbjct: 16 AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPL 75 Query: 97 LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLA 156 LQ L L N + +V A L L+ LDLS N + A L AL+ L + N L Sbjct: 76 LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELT 135 Query: 157 RLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWL 216 + A +L LRSL L N L LA G L AL L + NP+ C C + L W Sbjct: 136 FIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWA 195 Query: 217 RRHPLPASEAETVLCVWPGRLTLSPLT 243 + E + + C P L +PL+ Sbjct: 196 LTTAVSIPEQDNIACTSPHVLKGTPLS 222 >gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens] Length = 578 Score = 98.2 bits (243), Expect = 9e-21 Identities = 79/194 (40%), Positives = 92/194 (47%), Gaps = 15/194 (7%) Query: 73 LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS----- 127 L AL L HN + + GAF G +L LDL N L ++ AF GL AL+ L L+ Sbjct: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351 Query: 128 -ANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL 186 L A APL LR L LAGN L+RL PAAL L L L ++ N LA L P Sbjct: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNALAGLDPDE 410 Query: 187 L------GRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240 L G LP L L NP CGCA RPL AWLR ++ + C P L Sbjct: 411 LRALERDGGLPG-PRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDR 469 Query: 241 PLTAFSDAAFSHCA 254 PL D A CA Sbjct: 470 PLLDL-DGARLRCA 482 Score = 37.0 bits (84), Expect = 0.025 Identities = 29/73 (39%), Positives = 33/73 (45%), Gaps = 7/73 (9%) Query: 135 APGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALD 194 A G PL L L L N + +E A LP L +L L N L AL G LPAL Sbjct: 284 AAGVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALR 341 Query: 195 ALHL-----RGNP 202 +L L RG P Sbjct: 342 SLQLNHALVRGGP 354 Score = 35.8 bits (81), Expect = 0.055 Identities = 32/96 (33%), Positives = 40/96 (41%), Gaps = 13/96 (13%) Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGA------------L 166 G +LL A+ E P P A RNL++ G L L AA L Sbjct: 231 GGPKLLLRCASGAELRQPPRDVPPDA-RNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRL 289 Query: 167 PLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNP 202 PLL +L L N + + G LP+L AL L NP Sbjct: 290 PLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325 >gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens] Length = 578 Score = 98.2 bits (243), Expect = 9e-21 Identities = 79/194 (40%), Positives = 92/194 (47%), Gaps = 15/194 (7%) Query: 73 LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS----- 127 L AL L HN + + GAF G +L LDL N L ++ AF GL AL+ L L+ Sbjct: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351 Query: 128 -ANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL 186 L A APL LR L LAGN L+RL PAAL L L L ++ N LA L P Sbjct: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNALAGLDPDE 410 Query: 187 L------GRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240 L G LP L L NP CGCA RPL AWLR ++ + C P L Sbjct: 411 LRALERDGGLPG-PRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDR 469 Query: 241 PLTAFSDAAFSHCA 254 PL D A CA Sbjct: 470 PLLDL-DGARLRCA 482 Score = 37.0 bits (84), Expect = 0.025 Identities = 29/73 (39%), Positives = 33/73 (45%), Gaps = 7/73 (9%) Query: 135 APGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALD 194 A G PL L L L N + +E A LP L +L L N L AL G LPAL Sbjct: 284 AAGVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALR 341 Query: 195 ALHL-----RGNP 202 +L L RG P Sbjct: 342 SLQLNHALVRGGP 354 Score = 35.8 bits (81), Expect = 0.055 Identities = 32/96 (33%), Positives = 40/96 (41%), Gaps = 13/96 (13%) Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGA------------L 166 G +LL A+ E P P A RNL++ G L L AA L Sbjct: 231 GGPKLLLRCASGAELRQPPRDVPPDA-RNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRL 289 Query: 167 PLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNP 202 PLL +L L N + + G LP+L AL L NP Sbjct: 290 PLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325 >gi|225579152 insulin-like growth factor binding protein, acid labile subunit isoform 1 precursor [Homo sapiens] Length = 643 Score = 97.4 bits (241), Expect = 2e-20 Identities = 76/206 (36%), Positives = 97/206 (47%), Gaps = 8/206 (3%) Query: 4 PSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLG---APDCPEVCTCVPGGLAS---- 56 P S P L L LLL W S + G+ G P CP C C A Sbjct: 37 PQASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSV 96 Query: 57 -CSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAF 115 CS+ +L +P G+ +AL LD N + ++PP AF +L L+L+ L S+ +A Sbjct: 97 FCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQAL 156 Query: 116 WGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQ 175 GL L L L NQL +LA GTFA AL +L L+ NRL+RLE L L L+L Sbjct: 157 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 216 Query: 176 DNELAALAPGLLGRLPALDALHLRGN 201 N LA L L +L L L GN Sbjct: 217 WNSLAVLPDAAFRGLGSLRELVLAGN 242 Score = 92.0 bits (227), Expect = 6e-19 Identities = 71/219 (32%), Positives = 96/219 (43%), Gaps = 37/219 (16%) Query: 72 RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131 +L +L L+ + + + P F G L+RL L++NGL + ++ WGL L LDL++NQL Sbjct: 425 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 484 Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL---LG 188 L F L L L L+ NRLA L ALG L L + N L AL L LG Sbjct: 485 THLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 544 Query: 189 RL-----------------PALDALHLRGNPWGCGCALRPLCAWLRRHPL---------- 221 RL P L+ L L GNPW CGC L+ L + ++P Sbjct: 545 RLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAIC 604 Query: 222 -------PASEAETVLCVWPGRLTLSPLTAFSDAAFSHC 253 PA + C P + L S+A F+ C Sbjct: 605 EGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643 Score = 77.4 bits (189), Expect = 2e-14 Identities = 56/142 (39%), Positives = 71/142 (50%), Gaps = 4/142 (2%) Query: 64 AVPPGLSLR----LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLG 119 AV P + R LR L+L NR+ L P F+G L+ LDL N L ++ F L Sbjct: 221 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280 Query: 120 ALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNEL 179 LQ L L N + A+APG F L+ALR L L+ NR+A L L LR L L N + Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340 Query: 180 AALAPGLLGRLPALDALHLRGN 201 A+L P L L+ L L N Sbjct: 341 ASLRPRTFKDLHFLEELQLGHN 362 Score = 74.3 bits (181), Expect = 1e-13 Identities = 52/129 (40%), Positives = 69/129 (53%) Query: 73 LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132 L +L L +NR+ L G F G G+L L+L N L + AF GLG+L+ L L+ N+L Sbjct: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 245 Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192 L P F+ L LR L L+ N L ++ LP L+ L L N +AA+APG L A Sbjct: 246 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 305 Query: 193 LDALHLRGN 201 L L L N Sbjct: 306 LRWLDLSHN 314 Score = 73.9 bits (180), Expect = 2e-13 Identities = 48/130 (36%), Positives = 67/130 (51%) Query: 72 RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131 RL+ L LD N + A+ PGAF G AL+ LDL N + + F GL L++L LS N + Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340 Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLP 191 +L P TF L L L L NR+ +L + L L L+L N+L + G L Sbjct: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400 Query: 192 ALDALHLRGN 201 + ++L GN Sbjct: 401 NVAVMNLSGN 410 Score = 70.5 bits (171), Expect = 2e-12 Identities = 48/135 (35%), Positives = 66/135 (48%), Gaps = 1/135 (0%) Query: 67 PGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDL 126 PGL L LR L L HN + +L P F L+ L L N + + R+F GLG L++L L Sbjct: 325 PGL-LGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTL 383 Query: 127 SANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL 186 NQL+ + G F L + ++L+GN L L L L SL L+ + L + P Sbjct: 384 DHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 443 Query: 187 LGRLPALDALHLRGN 201 L L L L+ N Sbjct: 444 FTGLSGLRRLFLKDN 458 Score = 69.3 bits (168), Expect = 4e-12 Identities = 49/129 (37%), Positives = 61/129 (47%) Query: 73 LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132 L L L HNR+R L +F G G L+ L L N L V AF GL + +++LS N L Sbjct: 354 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR 413 Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192 L F L L +L L G+ L R+ P L LR L L+DN L + L L Sbjct: 414 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 473 Query: 193 LDALHLRGN 201 L L L N Sbjct: 474 LLELDLTSN 482 Score = 67.8 bits (164), Expect = 1e-11 Identities = 53/139 (38%), Positives = 67/139 (48%), Gaps = 1/139 (0%) Query: 63 PAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQ 122 PA+ GL+ LR L L N +RA+ F LQ+L L N + +V AF GL AL+ Sbjct: 249 PALFSGLA-ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 307 Query: 123 LLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAAL 182 LDLS N++ L TF L LR L L+ N +A L P L L L L N + L Sbjct: 308 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 367 Query: 183 APGLLGRLPALDALHLRGN 201 A L L+ L L N Sbjct: 368 AERSFEGLGQLEVLTLDHN 386 Score = 66.2 bits (160), Expect = 4e-11 Identities = 47/117 (40%), Positives = 57/117 (48%), Gaps = 4/117 (3%) Query: 76 LLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALA 135 L L N + LP AF G G+L+ L L N L + F GL L+ LDLS N L A+ Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272 Query: 136 PGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALA----PGLLG 188 F L L+ L L N +A + P A L LR L L N +A L PGLLG Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG 329 Score = 62.0 bits (149), Expect = 7e-10 Identities = 50/146 (34%), Positives = 69/146 (47%), Gaps = 3/146 (2%) Query: 62 LPAVPPGLSLRLRALL---LDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGL 118 + AV PG L L+AL L HNRV L F G L+ L L N + S+ R F L Sbjct: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 351 Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNE 178 L+ L L N++ LA +F L L L+L N+L ++ A L + ++L N Sbjct: 352 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411 Query: 179 LAALAPGLLGRLPALDALHLRGNPWG 204 L L + L L +LHL G+ G Sbjct: 412 LRNLPEQVFRGLGKLHSLHLEGSCLG 437 Score = 33.5 bits (75), Expect = 0.27 Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 9/89 (10%) Query: 62 LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121 LPA G R L + HNR+ ALP A G L+ L LR N L + + L Sbjct: 511 LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGL 566 Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSL 150 + L L N + PL+ALR+ +L Sbjct: 567 ERLWLEGNPWDC-----GCPLKALRDFAL 590 >gi|13194201 reticulon 4 receptor precursor [Homo sapiens] Length = 473 Score = 97.1 bits (240), Expect = 2e-20 Identities = 73/192 (38%), Positives = 92/192 (47%), Gaps = 4/192 (2%) Query: 63 PAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQ 122 PA GL RL L LD ++ L PG F G ALQ L L++N L ++ F LG L Sbjct: 123 PATFHGLG-RLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLT 181 Query: 123 LLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAAL 182 L L N++ ++ F L +L L L NR+A + P A L L +L L N L+AL Sbjct: 182 HLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSAL 241 Query: 183 APGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242 L L AL L L NPW C C RPL AWL++ +SE V C P RL L Sbjct: 242 PTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSE---VPCSLPQRLAGRDL 298 Query: 243 TAFSDAAFSHCA 254 + CA Sbjct: 299 KRLAANDLQGCA 310 Score = 85.5 bits (210), Expect = 6e-17 Identities = 66/186 (35%), Positives = 79/186 (42%), Gaps = 11/186 (5%) Query: 19 LSPWPVWAQVSATASPSGSLGAPDCPEVCTCV--PGGLASCSALSLPAVPPGLSLRLRAL 76 L W +W Q A+P CP C C P SC L AVP G+ + + Sbjct: 11 LLAWVLWLQAWQVAAP--------CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRI 62 Query: 77 LLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSAN-QLEALA 135 L NR+ +P +F L L L N L + AF GL L+ LDLS N QL ++ Sbjct: 63 FLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVD 122 Query: 136 PGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDA 195 P TF L L L L L L P L L+ L LQDN L AL L L Sbjct: 123 PATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTH 182 Query: 196 LHLRGN 201 L L GN Sbjct: 183 LFLHGN 188 >gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] Length = 420 Score = 96.7 bits (239), Expect = 3e-20 Identities = 68/182 (37%), Positives = 88/182 (48%), Gaps = 3/182 (1%) Query: 72 RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131 RL++L L ++ +LP F G +LQ L L+EN L + F L L L L N+L Sbjct: 132 RLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRL 191 Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLP 191 L F L +L L L GNRL + AA L L L L +N LA+L L LP Sbjct: 192 RLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLP 251 Query: 192 ALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAFS 251 +L+ L L NPW C C RPL AW +R + +S+ V C P L A +A F Sbjct: 252 SLEFLRLNANPWACDCRARPLWAWFQRARVSSSD---VTCATPPERQGRDLRALREADFQ 308 Query: 252 HC 253 C Sbjct: 309 AC 310 >gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo sapiens] Length = 345 Score = 96.7 bits (239), Expect = 3e-20 Identities = 68/216 (31%), Positives = 96/216 (44%), Gaps = 3/216 (1%) Query: 43 CPEVCTCVPG-GLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLD 101 CP+ C C CS L +P L + R L L N++ LP AF L L+ Sbjct: 21 CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80 Query: 102 LRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPA 161 L N L ++ AF GL LQ+L+L+ N L +L F L LR L L+ N ++ L P Sbjct: 81 LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHL-PT 139 Query: 162 ALGAL-PLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHP 220 +LG L L++Q N+L L LL +P++ L L+ N W C C L L WL + Sbjct: 140 SLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFV 199 Query: 221 LPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQP 256 + ++C P L + C P Sbjct: 200 YKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLP 235 >gi|194018474 leucine rich repeat containing 52 [Homo sapiens] Length = 313 Score = 95.9 bits (237), Expect = 4e-20 Identities = 77/269 (28%), Positives = 107/269 (39%), Gaps = 5/269 (1%) Query: 17 LLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRAL 76 L P P W S G + CP C C + C+ L P + L R L Sbjct: 3 LASGPGPGWLLFSFGM---GLVSGSKCPNNCLCQAQEVI-CTGKQLTEYPLDIPLNTRRL 58 Query: 77 LLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAP 136 L+ NR+ +LP L LD + N + V F G+ L LDLS+N L +++P Sbjct: 59 FLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISP 118 Query: 137 GTFAPLRALRNLSLAGN-RLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDA 195 TF+ L L L++A N L L LR L L++ L L L L L+ Sbjct: 119 FTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLET 178 Query: 196 LHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQ 255 L L GNPW C C+ +L + S+ CV P LT P+T + C Sbjct: 179 LFLSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCIT 238 Query: 256 PLALRDLAVVYTLGPASFLVSLASCLALG 284 L +D + +G F + G Sbjct: 239 HLDHKDYIFLLLIGFCIFAAGTVAAWLTG 267 >gi|4826772 insulin-like growth factor binding protein, acid labile subunit isoform 2 precursor [Homo sapiens] Length = 605 Score = 95.1 bits (235), Expect = 8e-20 Identities = 73/197 (37%), Positives = 94/197 (47%), Gaps = 8/197 (4%) Query: 13 LLLLLLLSPWPVWAQVSATASPSGSLG---APDCPEVCTCVPGGLAS-----CSALSLPA 64 L L LLL W S + G+ G P CP C C A CS+ +L Sbjct: 8 LALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTR 67 Query: 65 VPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLL 124 +P G+ +AL LD N + ++PP AF +L L+L+ L S+ +A GL L L Sbjct: 68 LPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHL 127 Query: 125 DLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAP 184 L NQL +LA GTFA AL +L L+ NRL+RLE L L L+L N LA L Sbjct: 128 HLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPD 187 Query: 185 GLLGRLPALDALHLRGN 201 L +L L L GN Sbjct: 188 AAFRGLGSLRELVLAGN 204 Score = 92.0 bits (227), Expect = 6e-19 Identities = 71/219 (32%), Positives = 96/219 (43%), Gaps = 37/219 (16%) Query: 72 RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131 +L +L L+ + + + P F G L+RL L++NGL + ++ WGL L LDL++NQL Sbjct: 387 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 446 Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL---LG 188 L F L L L L+ NRLA L ALG L L + N L AL L LG Sbjct: 447 THLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 506 Query: 189 RL-----------------PALDALHLRGNPWGCGCALRPLCAWLRRHPL---------- 221 RL P L+ L L GNPW CGC L+ L + ++P Sbjct: 507 RLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAIC 566 Query: 222 -------PASEAETVLCVWPGRLTLSPLTAFSDAAFSHC 253 PA + C P + L S+A F+ C Sbjct: 567 EGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 605 Score = 77.4 bits (189), Expect = 2e-14 Identities = 56/142 (39%), Positives = 71/142 (50%), Gaps = 4/142 (2%) Query: 64 AVPPGLSLR----LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLG 119 AV P + R LR L+L NR+ L P F+G L+ LDL N L ++ F L Sbjct: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242 Query: 120 ALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNEL 179 LQ L L N + A+APG F L+ALR L L+ NR+A L L LR L L N + Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302 Query: 180 AALAPGLLGRLPALDALHLRGN 201 A+L P L L+ L L N Sbjct: 303 ASLRPRTFKDLHFLEELQLGHN 324 Score = 74.3 bits (181), Expect = 1e-13 Identities = 52/129 (40%), Positives = 69/129 (53%) Query: 73 LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132 L +L L +NR+ L G F G G+L L+L N L + AF GLG+L+ L L+ N+L Sbjct: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207 Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192 L P F+ L LR L L+ N L ++ LP L+ L L N +AA+APG L A Sbjct: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 267 Query: 193 LDALHLRGN 201 L L L N Sbjct: 268 LRWLDLSHN 276 Score = 73.9 bits (180), Expect = 2e-13 Identities = 48/130 (36%), Positives = 67/130 (51%) Query: 72 RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131 RL+ L LD N + A+ PGAF G AL+ LDL N + + F GL L++L LS N + Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302 Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLP 191 +L P TF L L L L NR+ +L + L L L+L N+L + G L Sbjct: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362 Query: 192 ALDALHLRGN 201 + ++L GN Sbjct: 363 NVAVMNLSGN 372 Score = 70.5 bits (171), Expect = 2e-12 Identities = 48/135 (35%), Positives = 66/135 (48%), Gaps = 1/135 (0%) Query: 67 PGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDL 126 PGL L LR L L HN + +L P F L+ L L N + + R+F GLG L++L L Sbjct: 287 PGL-LGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTL 345 Query: 127 SANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL 186 NQL+ + G F L + ++L+GN L L L L SL L+ + L + P Sbjct: 346 DHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 405 Query: 187 LGRLPALDALHLRGN 201 L L L L+ N Sbjct: 406 FTGLSGLRRLFLKDN 420 Score = 69.3 bits (168), Expect = 4e-12 Identities = 49/129 (37%), Positives = 61/129 (47%) Query: 73 LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132 L L L HNR+R L +F G G L+ L L N L V AF GL + +++LS N L Sbjct: 316 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR 375 Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192 L F L L +L L G+ L R+ P L LR L L+DN L + L L Sbjct: 376 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 435 Query: 193 LDALHLRGN 201 L L L N Sbjct: 436 LLELDLTSN 444 Score = 67.8 bits (164), Expect = 1e-11 Identities = 53/139 (38%), Positives = 67/139 (48%), Gaps = 1/139 (0%) Query: 63 PAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQ 122 PA+ GL+ LR L L N +RA+ F LQ+L L N + +V AF GL AL+ Sbjct: 211 PALFSGLA-ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 269 Query: 123 LLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAAL 182 LDLS N++ L TF L LR L L+ N +A L P L L L L N + L Sbjct: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 329 Query: 183 APGLLGRLPALDALHLRGN 201 A L L+ L L N Sbjct: 330 AERSFEGLGQLEVLTLDHN 348 Score = 66.2 bits (160), Expect = 4e-11 Identities = 47/117 (40%), Positives = 57/117 (48%), Gaps = 4/117 (3%) Query: 76 LLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALA 135 L L N + LP AF G G+L+ L L N L + F GL L+ LDLS N L A+ Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234 Query: 136 PGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALA----PGLLG 188 F L L+ L L N +A + P A L LR L L N +A L PGLLG Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG 291 Score = 62.0 bits (149), Expect = 7e-10 Identities = 50/146 (34%), Positives = 69/146 (47%), Gaps = 3/146 (2%) Query: 62 LPAVPPGLSLRLRALL---LDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGL 118 + AV PG L L+AL L HNRV L F G L+ L L N + S+ R F L Sbjct: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313 Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNE 178 L+ L L N++ LA +F L L L+L N+L ++ A L + ++L N Sbjct: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373 Query: 179 LAALAPGLLGRLPALDALHLRGNPWG 204 L L + L L +LHL G+ G Sbjct: 374 LRNLPEQVFRGLGKLHSLHLEGSCLG 399 Score = 33.5 bits (75), Expect = 0.27 Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 9/89 (10%) Query: 62 LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121 LPA G R L + HNR+ ALP A G L+ L LR N L + + L Sbjct: 473 LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGL 528 Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSL 150 + L L N + PL+ALR+ +L Sbjct: 529 ERLWLEGNPWDC-----GCPLKALRDFAL 552 >gi|88702793 slit-like 2 [Homo sapiens] Length = 673 Score = 95.1 bits (235), Expect = 8e-20 Identities = 71/188 (37%), Positives = 86/188 (45%), Gaps = 16/188 (8%) Query: 11 PLLL-LLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGL 69 PLLL LLLLL+ P G CP C C C+A VP + Sbjct: 6 PLLLPLLLLLALGP---------------GVQGCPSGCQCSQPQTVFCTARQGTTVPRDV 50 Query: 70 SLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSAN 129 L + N + L G+FAG LQ LDL +N + S+ F L L LDL+AN Sbjct: 51 PPDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTAN 110 Query: 130 QLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGR 189 +L + TF LR L L L NR+ ++P A L L L LQDNEL AL P L R Sbjct: 111 RLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPR 170 Query: 190 LPALDALH 197 L LD H Sbjct: 171 LLLLDLSH 178 Score = 87.4 bits (215), Expect = 2e-17 Identities = 90/265 (33%), Positives = 108/265 (40%), Gaps = 22/265 (8%) Query: 62 LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121 L A+PP RL L L HN + AL PG A ++ L L GL + F L L Sbjct: 160 LRALPPLRLPRLLLLDLSHNSLLALEPGILDTAN-VEALRLAGLGLQQLDEGLFSRLRNL 218 Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSLAGN-RLARLEPAALGALPLLRSLSLQDNELA 180 LD+S NQLE + P LR L L LAGN R+A+L P L L L+ L + + L Sbjct: 219 HDLDVSDNQLERVPP-VIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQ 277 Query: 181 ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWP----GR 236 AL L G P L L NP+ C C L W+R + + E C +P GR Sbjct: 278 ALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGR 337 Query: 237 LTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRR 296 L L D A C A A V T P + AL S L Sbjct: 338 LLLE-----LDYADFGCP---ATTTTATVPTTRPV-----VREPTALSSSLAPTWLSPTE 384 Query: 297 LRTAALRPP--RPPDPNPDPDPHGC 319 T A PP PP P P P C Sbjct: 385 PATEAPSPPSTAPPTVGPVPQPQDC 409 >gi|4758460 glycoprotein V (platelet) [Homo sapiens] Length = 560 Score = 92.8 bits (229), Expect = 4e-19 Identities = 68/184 (36%), Positives = 85/184 (46%), Gaps = 1/184 (0%) Query: 62 LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENG-LHSVHVRAFWGLGA 120 LP V G L+ L L+ ++R LP AF L+ L + + L ++ AF GLG Sbjct: 281 LPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGE 340 Query: 121 LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELA 180 LQ+L L +N L AL G L LR +SL NRL L A L L S+ L N+L Sbjct: 341 LQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLE 400 Query: 181 ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240 L + G LP L + L N W C C L P WLR+H E C PG Sbjct: 401 TLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGL 460 Query: 241 PLTA 244 PL A Sbjct: 461 PLWA 464 Score = 75.5 bits (184), Expect = 6e-14 Identities = 72/214 (33%), Positives = 89/214 (41%), Gaps = 28/214 (13%) Query: 73 LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132 L L LDHN +R + F LQ L L +N L + F L L+LLDLS N L Sbjct: 124 LEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLT 183 Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192 L G L L L NRL L+ L +L L L N + ++APG RLP Sbjct: 184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPN 243 Query: 193 LDALHLRGNPWGCGCALRPLCAWLRRHPL--------PASEAETVLC--------VWPGR 236 L +L L N A P +L H L P +E VL +W R Sbjct: 244 LSSLTLSRN----HLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR 299 Query: 237 LTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGP 270 L L A AAF + ++ LR L V TL P Sbjct: 300 TQLRTLPA---AAFRNLSR---LRYLGV--TLSP 325 Score = 69.7 bits (169), Expect = 3e-12 Identities = 51/143 (35%), Positives = 65/143 (45%), Gaps = 3/143 (2%) Query: 62 LPAVPPGLS---LRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGL 118 + AV PG ++L+ L L N++ LP L++L L N L + F L Sbjct: 86 ISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKL 145 Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNE 178 LQ L L+ NQL+ L F L L+ L L+GN L L LGA L L L N Sbjct: 146 VNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNR 205 Query: 179 LAALAPGLLGRLPALDALHLRGN 201 L +L GLL L AL L N Sbjct: 206 LVSLDSGLLNSLGALTELQFHRN 228 Score = 60.5 bits (145), Expect = 2e-09 Identities = 51/159 (32%), Positives = 68/159 (42%), Gaps = 23/159 (14%) Query: 43 CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDL 102 CP C CV A CS G R+ AL L N L G G G LQ Sbjct: 21 CPPACKCVFRDAAQCSG--------GDVARISALGLPTNLTHILLFGM--GRGVLQS--- 67 Query: 103 RENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAA 162 ++F G+ LQ L +S + + A+APGTF+ L L+ L L+ N++ L A Sbjct: 68 ----------QSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGAL 117 Query: 163 LGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201 L + LL L L N L + + +L L L L N Sbjct: 118 LDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQN 156 Score = 57.8 bits (138), Expect = 1e-08 Identities = 74/241 (30%), Positives = 100/241 (41%), Gaps = 23/241 (9%) Query: 71 LRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQ 130 + L+ L L+ N++ LP F L+ LDL N L + L+ L L +N+ Sbjct: 146 VNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNR 205 Query: 131 LEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRL 190 L +L G L AL L N + + P A LP L SL+L N LA L L Sbjct: 206 LVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHS 265 Query: 191 PALDALHLRGNP--------WGCGCALRPLCAWLRR---HPLPASEAETVLCVWPGRLTL 239 L L L NP +G L+ L WL R LPA+ + + +TL Sbjct: 266 HNLTLLTLFENPLAELPGVLFGEMGGLQEL--WLNRTQLRTLPAAAFRNLSRLRYLGVTL 323 Query: 240 SP-LTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSG-LTACRARRRRL 297 SP L+A AF Q L + +++ G L +L L G G L RR RL Sbjct: 324 SPRLSALPQGAF----QGLGELQVLALHSNG----LTALPDGLLRGLGKLRQVSLRRNRL 375 Query: 298 R 298 R Sbjct: 376 R 376 Score = 51.2 bits (121), Expect = 1e-06 Identities = 48/152 (31%), Positives = 61/152 (40%), Gaps = 3/152 (1%) Query: 54 LASCSALSLPAVPPGL---SLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSV 110 L S +L +P GL +L LLL NR+ +L G GAL L N + S+ Sbjct: 174 LLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSI 233 Query: 111 HVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLR 170 AF L L L LS N L L F L L+L N LA L G + L+ Sbjct: 234 APGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQ 293 Query: 171 SLSLQDNELAALAPGLLGRLPALDALHLRGNP 202 L L +L L L L L + +P Sbjct: 294 ELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSP 325 >gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo sapiens] Length = 593 Score = 92.8 bits (229), Expect = 4e-19 Identities = 72/195 (36%), Positives = 87/195 (44%), Gaps = 18/195 (9%) Query: 5 SWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLAS-CSALSLP 63 +W PLL LLLL P GS G+ CP VC C A C L Sbjct: 10 AWPPWPPLLFLLLL---------------PGGSGGS--CPAVCDCTSQPQAVLCGHRQLE 52 Query: 64 AVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQL 123 AVP GL L L L NR+ L G + LQ LDL N L ++ AF GL +L Sbjct: 53 AVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLT 112 Query: 124 LDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALA 183 L L N+L + PG F+ L AL L L N++ A G L L+ L + DN L +A Sbjct: 113 LRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVA 172 Query: 184 PGLLGRLPALDALHL 198 PG L L L L Sbjct: 173 PGAFAGLAKLSTLTL 187 Score = 63.2 bits (152), Expect = 3e-10 Identities = 57/190 (30%), Positives = 78/190 (41%), Gaps = 30/190 (15%) Query: 54 LASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLR---------- 103 L++ L+L +P ++LRLR L + LP GA G G L+ L++ Sbjct: 192 LSTVPGLALARLPALVALRLREL-----DIGRLPAGALRGLGQLKELEIHLWPSLEALDP 246 Query: 104 --------------ENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLS 149 L SV +A + L L++LDLS N + A+ +PL L+ L Sbjct: 247 GSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELR 306 Query: 150 LAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCAL 209 L+G L + A L L + DN L L L L L GNP C C L Sbjct: 307 LSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRL 366 Query: 210 RPLCAWLRRH 219 L LRRH Sbjct: 367 LWLLR-LRRH 375 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.322 0.137 0.444 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 16,604,603 Number of Sequences: 37866 Number of extensions: 946262 Number of successful extensions: 9181 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 247 Number of HSP's successfully gapped in prelim test: 182 Number of HSP's that attempted gapping in prelim test: 6927 Number of HSP's gapped (non-prelim): 1412 length of query: 334 length of database: 18,247,518 effective HSP length: 103 effective length of query: 231 effective length of database: 14,347,320 effective search space: 3314230920 effective search space used: 3314230920 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.9 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.