Search of human proteins with 61966761

Search of human proteins with 61966761

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
         (334 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|61966761 leucine rich repeat containing 26 [Homo sapiens]          679   0.0  
gi|52353306 leucine rich repeat containing 55 [Homo sapiens]          126   3e-29
gi|239752702 PREDICTED: leucine rich repeat containing 38, parti...   123   2e-28
gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo ...   122   6e-28
gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo ...   122   6e-28
gi|188528675 slit homolog 1 [Homo sapiens]                            120   2e-27
gi|229089140 leucine rich repeat containing 24 [Homo sapiens]         116   2e-26
gi|194306623 immunoglobulin superfamily containing leucine-rich ...   115   7e-26
gi|194306621 immunoglobulin superfamily containing leucine-rich ...   115   7e-26
gi|39930401 immunoglobulin superfamily containing leucine-rich r...   115   7e-26
gi|194306618 immunoglobulin superfamily containing leucine-rich ...   115   7e-26
gi|84781739 leucine-rich repeats and transmembrane domains 2 [Ho...   109   4e-24
gi|11321571 slit homolog 3 [Homo sapiens]                             106   3e-23
gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]      106   3e-23
gi|4759146 slit homolog 2 [Homo sapiens]                              105   6e-23
gi|194440719 chondroadherin-like [Homo sapiens]                       103   3e-22
gi|76880480 hypothetical protein LOC9865 [Homo sapiens]               102   5e-22
gi|41582239 immunoglobulin superfamily containing leucine-rich r...   101   1e-21
gi|5031809 immunoglobulin superfamily containing leucine-rich re...   101   1e-21
gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]           98   9e-21
gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]           98   9e-21
gi|225579152 insulin-like growth factor binding protein, acid la...    97   2e-20
gi|13194201 reticulon 4 receptor precursor [Homo sapiens]              97   2e-20
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]                 97   3e-20
gi|10190722 leucine-rich repeats and transmembrane domains 1 [Ho...    97   3e-20
gi|194018474 leucine rich repeat containing 52 [Homo sapiens]          96   4e-20
gi|4826772 insulin-like growth factor binding protein, acid labi...    95   8e-20
gi|88702793 slit-like 2 [Homo sapiens]                                 95   8e-20
gi|4758460 glycoprotein V (platelet) [Homo sapiens]                    93   4e-19
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo...    93   4e-19

>gi|61966761 leucine rich repeat containing 26 [Homo sapiens]
          Length = 334

 Score =  679 bits (1751), Expect = 0.0
 Identities = 334/334 (100%), Positives = 334/334 (100%)

Query: 1   MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSAL 60
           MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSAL
Sbjct: 1   MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSAL 60

Query: 61  SLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGA 120
           SLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGA
Sbjct: 61  SLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGA 120

Query: 121 LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELA 180
           LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELA
Sbjct: 121 LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELA 180

Query: 181 ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240
           ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS
Sbjct: 181 ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240

Query: 241 PLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTA 300
           PLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTA
Sbjct: 241 PLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTA 300

Query: 301 ALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA 334
           ALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA
Sbjct: 301 ALRPPRPPDPNPDPDPHGCASPADPGSPAAAAQA 334


>gi|52353306 leucine rich repeat containing 55 [Homo sapiens]
          Length = 341

 Score =  126 bits (316), Expect = 3e-29
 Identities = 95/296 (32%), Positives = 131/296 (44%), Gaps = 19/296 (6%)

Query: 3   GPSWSR------PRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLAS 56
           G +W++      P P +LL+ LL            A    S     CP +CTC    +  
Sbjct: 45  GDTWAQLPWPGPPHPAMLLISLL----------LAAGLMHSDAGTSCPVLCTC-RNQVVD 93

Query: 57  CSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFW 116
           CS+  L +VPP L +  R L L HNR+ A+PPG       LQ LDL  N L  +    F 
Sbjct: 94  CSSQRLFSVPPDLPMDTRNLSLAHNRITAVPPGYLTCYMELQVLDLHNNSLMELPRGLFL 153

Query: 117 GLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNR-LARLEPAALGALPLLRSLSLQ 175
               L  LDLS N    +    F     L ++ L+ N  L R+ P A   L  LR L L 
Sbjct: 154 HAKRLAHLDLSYNNFSHVPADMFQEAHGLVHIDLSHNPWLRRVHPQAFQGLMQLRDLDLS 213

Query: 176 DNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLR-RHPLPASEAETVLCVWP 234
              LA L+   L  LP L  L + GNPW CGC + PL  WLR R     ++++   C  P
Sbjct: 214 YGGLAFLSLEALEGLPGLVTLQIGGNPWVCGCTMEPLLKWLRNRIQRCTADSQLAECRGP 273

Query: 235 GRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTAC 290
             +  +PL + ++ +F  C   L L D   +  +G    + S+A+   LG     C
Sbjct: 274 PEVEGAPLFSLTEESFKACHLTLTLDDYLFIAFVGFVVSIASVATNFLLGITANCC 329


>gi|239752702 PREDICTED: leucine rich repeat containing 38, partial
           [Homo sapiens]
          Length = 254

 Score =  123 bits (309), Expect = 2e-28
 Identities = 82/231 (35%), Positives = 109/231 (47%), Gaps = 3/231 (1%)

Query: 57  CSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFW 116
           C    LP+VP    L +R LL+  NR++ +P   F   G L  LD R N L S+    F 
Sbjct: 2   CRDRGLPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFS 61

Query: 117 GLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQD 176
           G   L  LDLS N L  L  G F     L  LSLA N L  +   A   L  L+ L L D
Sbjct: 62  GSAKLVFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELND 121

Query: 177 NELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH--PLPASEAETVLCVWP 234
           N L +L+   L  LPAL +L L GNPW C C    L +W++ +   LP    + + C  P
Sbjct: 122 NNLRSLSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKG-LDEIQCSLP 180

Query: 235 GRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGS 285
                  L   S+A+FS C   L+L DL ++   G A  + ++ S   L +
Sbjct: 181 MESRRISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLAT 231


>gi|239747236 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  122 bits (305), Expect = 6e-28
 Identities = 81/226 (35%), Positives = 108/226 (47%), Gaps = 3/226 (1%)

Query: 62  LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121
           LP+VP    L +R LL+  NR++ +P   F   G L  LD R N L S+    F G   L
Sbjct: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220

Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAA 181
             LDLS N L  L  G F     L  LSLA N L  +   A   L  L+ L L DN L +
Sbjct: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280

Query: 182 LAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH--PLPASEAETVLCVWPGRLTL 239
           L+   L  LPAL +L L GNPW C C    L +W++ +   LP    + + C  P     
Sbjct: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKG-LDEIQCSLPMESRR 339

Query: 240 SPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGS 285
             L   S+A+FS C   L+L DL ++   G A  + ++ S   L +
Sbjct: 340 ISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLAT 385


>gi|239741057 PREDICTED: leucine rich repeat containing 38 [Homo
           sapiens]
          Length = 408

 Score =  122 bits (305), Expect = 6e-28
 Identities = 81/226 (35%), Positives = 108/226 (47%), Gaps = 3/226 (1%)

Query: 62  LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121
           LP+VP    L +R LL+  NR++ +P   F   G L  LD R N L S+    F G   L
Sbjct: 161 LPSVPDPFPLDVRKLLVAGNRIQRIPEDFFIFYGDLVYLDFRNNSLRSLEEGTFSGSAKL 220

Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAA 181
             LDLS N L  L  G F     L  LSLA N L  +   A   L  L+ L L DN L +
Sbjct: 221 VFLDLSYNNLTQLGAGAFRSAGRLVKLSLANNNLVGVHEDAFETLESLQVLELNDNNLRS 280

Query: 182 LAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH--PLPASEAETVLCVWPGRLTL 239
           L+   L  LPAL +L L GNPW C C    L +W++ +   LP    + + C  P     
Sbjct: 281 LSVAALAALPALRSLRLDGNPWLCDCDFAHLFSWIQENASKLPKG-LDEIQCSLPMESRR 339

Query: 240 SPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGS 285
             L   S+A+FS C   L+L DL ++   G A  + ++ S   L +
Sbjct: 340 ISLRELSEASFSECRFSLSLTDLCIIIFSGVAVSIAAIISSFFLAT 385


>gi|188528675 slit homolog 1 [Homo sapiens]
          Length = 1534

 Score =  120 bits (301), Expect = 2e-27
 Identities = 75/211 (35%), Positives = 109/211 (51%), Gaps = 4/211 (1%)

Query: 27  QVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRAL 86
           Q  A   P+ +L +  CP +CTC   G+  C    L A+P  L   +  + L+ N ++++
Sbjct: 266 QGEAGRVPTCTLSSGSCPAMCTC-SNGIVDCRGKGLTAIPANLPETMTEIRLELNGIKSI 324

Query: 87  PPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALR 146
           PPGAF+    L+R+DL  N +  +   AF GL +L  L L  N++  L  G F  L  L+
Sbjct: 325 PPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQ 384

Query: 147 NLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCG 206
            L L  N++  + P A   L  L  LSL DN++ +LA G    L A+  LHL  NP+ C 
Sbjct: 385 LLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICD 444

Query: 207 CALRPLCAWLRRHPLPASEAETVLCVWPGRL 237
           C L+ L  +LR +P+  S A    C  P RL
Sbjct: 445 CNLKWLADFLRTNPIETSGAR---CASPRRL 472



 Score =  102 bits (253), Expect = 6e-22
 Identities = 67/208 (32%), Positives = 99/208 (47%), Gaps = 7/208 (3%)

Query: 43  CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPP-GAFAGAGALQRLD 101
           CP  C C    +  CS+L L  +P  +      L L++N +  L   G F     L++++
Sbjct: 513 CPHKCRC-EANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKIN 571

Query: 102 LRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPA 161
           L  N +  +   AF G  ++  L L+ANQLE++  G F  L  LR L L  NR++ +   
Sbjct: 572 LSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHND 631

Query: 162 ALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPL 221
           +   L  +R LSL DN++  ++PG    L +L  L+L  NP+ C C L  L  WLR+  +
Sbjct: 632 SFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKI 691

Query: 222 PASEAETVLCVWPGRLTLSPL--TAFSD 247
                    C  P  L   PL   AF D
Sbjct: 692 VTGNPR---CQNPDFLRQIPLQDVAFPD 716



 Score = 94.4 bits (233), Expect = 1e-19
 Identities = 91/316 (28%), Positives = 119/316 (37%), Gaps = 44/316 (13%)

Query: 3   GPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSL 62
           G S    RP L LLL  + W               LGA  CP +CTC  G    C    L
Sbjct: 8   GSSAGPVRPELWLLLWAAAW--------------RLGASACPALCTCT-GTTVDCHGTGL 52

Query: 63  PAVPPGLSL------------------------RLRALLLDHNRVRALPPGAFAGAGALQ 98
            A+P  +                          +LR L L  N++ A+  GAF     L+
Sbjct: 53  QAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELE 112

Query: 99  RLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARL 158
           RL L  N LH +    F    AL  LDLS N ++A+    F     L+NL L  N+++ +
Sbjct: 113 RLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCI 172

Query: 159 EPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR 218
           E  A  AL  L  L+L +N +  +       +P L    L  N   C C L  L  WLR+
Sbjct: 173 EEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQ 232

Query: 219 HPLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLG--PASFLVS 276
            P      +   C  P  L    +     + FS   Q  A R      + G  PA    S
Sbjct: 233 RPTIGLFTQ---CSGPASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCS 289

Query: 277 LASCLALGSGLTACRA 292
                  G GLTA  A
Sbjct: 290 NGIVDCRGKGLTAIPA 305



 Score = 79.0 bits (193), Expect = 6e-15
 Identities = 55/182 (30%), Positives = 82/182 (45%), Gaps = 26/182 (14%)

Query: 36  GSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAG 95
           G L  P CP+ C C+   +  CS   L A+P G+   +  L LD N+   +P       G
Sbjct: 727 GCLPRPQCPQECACLDT-VVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVP-------G 778

Query: 96  ALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRL 155
            L                       LQL+DLS N++ +L+  +F  +  L  L L+ N L
Sbjct: 779 QLSTFKY------------------LQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820

Query: 156 ARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAW 215
             + P A   L  LR LSL  N+++ L  G+   + +L  L +  NP  C C LR L +W
Sbjct: 821 QCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSW 880

Query: 216 LR 217
           ++
Sbjct: 881 VK 882


>gi|229089140 leucine rich repeat containing 24 [Homo sapiens]
          Length = 513

 Score =  116 bits (291), Expect = 2e-26
 Identities = 95/288 (32%), Positives = 119/288 (41%), Gaps = 43/288 (14%)

Query: 8   RPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPP 67
           R   LL LLLLL P                L A  CP  C C       C AL L  VP 
Sbjct: 4   RAPALLPLLLLLLP----------------LRAAGCPAACRCY-SATVECGALRLRVVPL 46

Query: 68  GLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS 127
           G+    + L L  N +  L PGA A   AL+RL L  N L ++   AF     L  L L+
Sbjct: 47  GIPPGTQTLFLQDNNIARLEPGALAPLAALRRLYLHNNSLRALEAGAFRAQPRLLELALT 106

Query: 128 ANQLEALAPGTFAPLRALRNLSLAGNRLARL------------------------EPAAL 163
           +N+L  L  G F  L  LR L LAGN+LARL                        E  AL
Sbjct: 107 SNRLRGLRSGAFVGLAQLRVLYLAGNQLARLLDFTFLHLPRLQELHLQENSIELLEDQAL 166

Query: 164 GALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR--HPL 221
             L  L  L L  N+L  ++   L  L +L  L L  NPW C CAL  L AW++     L
Sbjct: 167 AGLSSLALLDLSRNQLGTISREALQPLASLQVLRLTENPWRCDCALHWLGAWIKEGGQRL 226

Query: 222 PASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLG 269
             S    ++C  P RL L  L   S ++       + ++ L +   LG
Sbjct: 227 LTSRDRKIMCAEPPRLALQSLLDVSHSSLICIPPSVHVQPLELTANLG 274


>gi|194306623 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  115 bits (287), Expect = 7e-26
 Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 12/224 (5%)

Query: 22  WPVWAQVSATASPSGSLGAPDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLL 78
           W VWA +    S         CPE C CV       A C+   L  VP GL   +  L L
Sbjct: 8   WLVWALLGVAGS---------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSL 58

Query: 79  DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138
             N++  L  GAFA    +  L L  N + +V   A   L  L+ LDLS N + +     
Sbjct: 59  SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118

Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198
              L AL+ L +  NRL  L   ALGALP LRSL + +N L  LAPG    L AL  L L
Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178

Query: 199 RGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242
             NP+ CGC L  L AW     +   E +++ C  P  L   P+
Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV 222


>gi|194306621 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  115 bits (287), Expect = 7e-26
 Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 12/224 (5%)

Query: 22  WPVWAQVSATASPSGSLGAPDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLL 78
           W VWA +    S         CPE C CV       A C+   L  VP GL   +  L L
Sbjct: 8   WLVWALLGVAGS---------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSL 58

Query: 79  DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138
             N++  L  GAFA    +  L L  N + +V   A   L  L+ LDLS N + +     
Sbjct: 59  SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118

Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198
              L AL+ L +  NRL  L   ALGALP LRSL + +N L  LAPG    L AL  L L
Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178

Query: 199 RGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242
             NP+ CGC L  L AW     +   E +++ C  P  L   P+
Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV 222


>gi|39930401 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  115 bits (287), Expect = 7e-26
 Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 12/224 (5%)

Query: 22  WPVWAQVSATASPSGSLGAPDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLL 78
           W VWA +    S         CPE C CV       A C+   L  VP GL   +  L L
Sbjct: 8   WLVWALLGVAGS---------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSL 58

Query: 79  DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138
             N++  L  GAFA    +  L L  N + +V   A   L  L+ LDLS N + +     
Sbjct: 59  SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118

Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198
              L AL+ L +  NRL  L   ALGALP LRSL + +N L  LAPG    L AL  L L
Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178

Query: 199 RGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242
             NP+ CGC L  L AW     +   E +++ C  P  L   P+
Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV 222


>gi|194306618 immunoglobulin superfamily containing leucine-rich
           repeat 2 [Homo sapiens]
          Length = 745

 Score =  115 bits (287), Expect = 7e-26
 Identities = 81/224 (36%), Positives = 102/224 (45%), Gaps = 12/224 (5%)

Query: 22  WPVWAQVSATASPSGSLGAPDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLL 78
           W VWA +    S         CPE C CV       A C+   L  VP GL   +  L L
Sbjct: 8   WLVWALLGVAGS---------CPEPCACVDKYAHQFADCAYKELREVPEGLPANVTTLSL 58

Query: 79  DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138
             N++  L  GAFA    +  L L  N + +V   A   L  L+ LDLS N + +     
Sbjct: 59  SANKITVLRRGAFADVTQVTSLWLAHNEVRTVEPGALAVLSQLKNLDLSHNFISSFPWSD 118

Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198
              L AL+ L +  NRL  L   ALGALP LRSL + +N L  LAPG    L AL  L L
Sbjct: 119 LRNLSALQLLKMNHNRLGSLPRDALGALPDLRSLRINNNRLRTLAPGTFDALSALSHLQL 178

Query: 199 RGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242
             NP+ CGC L  L AW     +   E +++ C  P  L   P+
Sbjct: 179 YHNPFHCGCGLVWLQAWAASTRVSLPEPDSIACASPPALQGVPV 222


>gi|84781739 leucine-rich repeats and transmembrane domains 2 [Homo
           sapiens]
          Length = 370

 Score =  109 bits (272), Expect = 4e-24
 Identities = 75/216 (34%), Positives = 94/216 (43%), Gaps = 1/216 (0%)

Query: 41  PDCPEVCTCVPGGL-ASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQR 99
           P CP  C C    L   CS L L  VPP +    R LLL +N++ ALP  AFA   +LQR
Sbjct: 37  PTCPFSCKCDSRSLEVDCSGLGLTTVPPDVPAATRTLLLLNNKLSALPSWAFANLSSLQR 96

Query: 100 LDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLE 159
           LDL  N L  +    F  L  L  L L  N +  L          LR+L L+ N LA+L 
Sbjct: 97  LDLSNNFLDRLPRSIFGDLTNLTELQLRNNSIRTLDRDLLRHSPLLRHLDLSINGLAQLP 156

Query: 160 PAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRH 219
           P     L  LRSLSL+ N L  L       L  L  L +  NPW C C LR    W+   
Sbjct: 157 PGLFDGLLALRSLSLRSNRLQNLDRLTFEPLANLQLLQVGDNPWECDCNLREFKHWMEWF 216

Query: 220 PLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQ 255
                  + + C  P  L    +       F++C+Q
Sbjct: 217 SYRGGRLDQLACTLPKELRGKDMRMVPMEMFNYCSQ 252


>gi|11321571 slit homolog 3 [Homo sapiens]
          Length = 1523

 Score =  106 bits (265), Expect = 3e-23
 Identities = 68/217 (31%), Positives = 105/217 (48%), Gaps = 4/217 (1%)

Query: 34  PSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAG 93
           PS +  +  CP  CTC    +  C    L  +P  L   +  + L+ N ++A+P GAF  
Sbjct: 271 PSCNANSISCPSPCTC-SNNIVDCRGKGLMEIPANLPEGIVEIRLEQNSIKAIPAGAFTQ 329

Query: 94  AGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGN 153
              L+R+D+ +N +  +   AF GL +L  L L  N++  +A G F  L +L+ L L  N
Sbjct: 330 YKKLKRIDISKNQISDIAPDAFQGLKSLTSLVLYGNKITEIAKGLFDGLVSLQLLLLNAN 389

Query: 154 RLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLC 213
           ++  L       L  L  LSL DN+L  ++ GL   L ++  LHL  NP+ C C L+ L 
Sbjct: 390 KINCLRVNTFQDLQNLNLLSLYDNKLQTISKGLFAPLQSIQTLHLAQNPFVCDCHLKWLA 449

Query: 214 AWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAF 250
            +L+ +P+  S A    C  P RL    ++      F
Sbjct: 450 DYLQDNPIETSGAR---CSSPRRLANKRISQIKSKKF 483



 Score = 91.7 bits (226), Expect = 8e-19
 Identities = 59/177 (33%), Positives = 83/177 (46%), Gaps = 2/177 (1%)

Query: 43  CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPP-GAFAGAGALQRLD 101
           CPE C C  G +  CS   L  +P  L   +  L L+ N V  L   G F     L++++
Sbjct: 505 CPEKCRC-EGTIVDCSNQKLVRIPSHLPEYVTDLRLNDNEVSVLEATGIFKKLPNLRKIN 563

Query: 102 LRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPA 161
           L  N +  V   AF G  ++Q L L+ NQLE +    F  L  L+ L L  N +  +   
Sbjct: 564 LSNNKIKEVREGAFDGAASVQELMLTGNQLETVHGRVFRGLSGLKTLMLRSNLIGCVSND 623

Query: 162 ALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR 218
               L  +R LSL DN +  + PG    L +L  ++L  NP+ C C L  L  WLR+
Sbjct: 624 TFAGLSSVRLLSLYDNRITTITPGAFTTLVSLSTINLLSNPFNCNCHLAWLGKWLRK 680



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 67/232 (28%), Positives = 95/232 (40%), Gaps = 28/232 (12%)

Query: 30  ATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLR----------------- 72
           A AS      A  CP  CTC    +  C  L L AVP G+                    
Sbjct: 21  ALASVLSGPPAVACPTKCTCSAASV-DCHGLGLRAVPRGIPRNAERLDLDRNNITRITKM 79

Query: 73  -------LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLD 125
                  LR L L+ N+V  +  GAF     L+RL L +N L  +    F     L  LD
Sbjct: 80  DFAGLKNLRVLHLEDNQVSVIERGAFQDLKQLERLRLNKNKLQVLPELLFQSTPKLTRLD 139

Query: 126 LSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPG 185
           LS NQ++ +    F  +  ++NL L  N ++ +E  A  AL  L  L+L +N ++ +   
Sbjct: 140 LSENQIQGIPRKAFRGITDVKNLQLDNNHISCIEDGAFRALRDLEILTLNNNNISRILVT 199

Query: 186 LLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRL 237
               +P +  L L  N   C C L  L  WLR+     +  +  LC+ P  L
Sbjct: 200 SFNHMPKIRTLRLHSNHLYCDCHLAWLSDWLRQR---RTVGQFTLCMAPVHL 248



 Score = 76.3 bits (186), Expect = 4e-14
 Identities = 55/178 (30%), Positives = 80/178 (44%), Gaps = 26/178 (14%)

Query: 40  APDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQR 99
           +P CPE CTC+   +  CS   L A+P G+   +  L L+ N + A+P            
Sbjct: 722 SPRCPEQCTCMET-VVRCSNKGLRALPRGMPKDVTELYLEGNHLTAVP------------ 768

Query: 100 LDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLE 159
                        R    L  L L+DLS N +  L   TF+ +  L  L L+ NRL  + 
Sbjct: 769 -------------RELSALRHLTLIDLSNNSISMLTNYTFSNMSHLSTLILSYNRLRCIP 815

Query: 160 PAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLR 217
             A   L  LR L+L  N+++++  G    L +L  L L  NP  C C+LR L  W++
Sbjct: 816 VHAFNGLRSLRVLTLHGNDISSVPEGSFNDLTSLSHLALGTNPLHCDCSLRWLSEWVK 873


>gi|38490688 immunoglobulin superfamily, member 10 [Homo sapiens]
          Length = 2623

 Score =  106 bits (265), Expect = 3e-23
 Identities = 80/273 (29%), Positives = 119/273 (43%), Gaps = 46/273 (16%)

Query: 25  WAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVR 84
           +A +   A+P G      CP  C C       C+   L ++P  +   +  + L +N + 
Sbjct: 15  FAVICLVATPGGKA----CPRRCACYMPTEVHCTFRYLTSIPDSIPPNVERINLGYNSLV 70

Query: 85  ALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRA 144
            L    F+G   L+ L L  NG+H++  + F  L ALQ+L +S N++  L   TF  LR+
Sbjct: 71  RLMETDFSGLTKLELLMLHSNGIHTIPDKTFSDLQALQVLKMSYNKVRKLQKDTFYGLRS 130

Query: 145 LRNLS------------------------LAGNRLARLEPAALGALPLL--------RSL 172
           L  L                         L GN+L +L P    +L  L        + L
Sbjct: 131 LTRLHMDHNNIEFINPEVFYGLNFLRLVHLEGNQLTKLHPDTFVSLSYLQIFKISFIKFL 190

Query: 173 SLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHP---------LPA 223
            L DN L +L   ++  +P LD+L+L GNPW C C L+ L  W++  P          P+
Sbjct: 191 YLSDNFLTSLPQEMVSYMPDLDSLYLHGNPWTCDCHLKWLSDWIQEKPDVIKCKKDRSPS 250

Query: 224 SEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQP 256
           S  +  LC+ P      PL   S AAF  CA+P
Sbjct: 251 SAQQCPLCMNPRTSKGKPLAMVSAAAF-QCAKP 282


>gi|4759146 slit homolog 2 [Homo sapiens]
          Length = 1529

 Score =  105 bits (262), Expect = 6e-23
 Identities = 66/195 (33%), Positives = 95/195 (48%), Gaps = 4/195 (2%)

Query: 43  CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDL 102
           CP  CTC    +  C    L  +P  L   +  + L+ N ++ +PPGAF+    L+R+DL
Sbjct: 273 CPAACTC-SNNIVDCRGKGLTEIPTNLPETITEIRLEQNTIKVIPPGAFSPYKKLRRIDL 331

Query: 103 RENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAA 162
             N +  +   AF GL +L  L L  N++  L    F  L +L+ L L  N++  L   A
Sbjct: 332 SNNQISELAPDAFQGLRSLNSLVLYGNKITELPKSLFEGLFSLQLLLLNANKINCLRVDA 391

Query: 163 LGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLP 222
              L  L  LSL DN+L  +A G    L A+  +HL  NP+ C C L+ L  +L  +P+ 
Sbjct: 392 FQDLHNLNLLSLYDNKLQTIAKGTFSPLRAIQTMHLAQNPFICDCHLKWLADYLHTNPIE 451

Query: 223 ASEAETVLCVWPGRL 237
            S A    C  P RL
Sbjct: 452 TSGAR---CTSPRRL 463



 Score = 86.3 bits (212), Expect = 4e-17
 Identities = 55/177 (31%), Positives = 84/177 (47%), Gaps = 2/177 (1%)

Query: 43  CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPP-GAFAGAGALQRLD 101
           CPE C C  G    CS   L  +P  +      L L++N    L   G F     L++++
Sbjct: 506 CPEKCRC-EGTTVDCSNQKLNKIPEHIPQYTAELRLNNNEFTVLEATGIFKKLPQLRKIN 564

Query: 102 LRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPA 161
              N +  +   AF G   +  + L++N+LE +    F  L +L+ L L  NR+  +   
Sbjct: 565 FSNNKITDIEEGAFEGASGVNEILLTSNRLENVQHKMFKGLESLKTLMLRSNRITCVGND 624

Query: 162 ALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRR 218
           +   L  +R LSL DN++  +APG    L +L  L+L  NP+ C C L  L  WLR+
Sbjct: 625 SFIGLSSVRLLSLYDNQITTVAPGAFDTLHSLSTLNLLANPFNCNCYLAWLGEWLRK 681



 Score = 83.6 bits (205), Expect = 2e-16
 Identities = 62/202 (30%), Positives = 85/202 (42%), Gaps = 25/202 (12%)

Query: 43  CPEVCTCVPGGLASCSALSLPAVPPGL-----------------------SLR-LRALLL 78
           CP  C+C  G    C  L+L +VP  +                        LR LR L L
Sbjct: 28  CPAQCSC-SGSTVDCHGLALRSVPRNIPRNTERLDLNGNNITRITKTDFAGLRHLRVLQL 86

Query: 79  DHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGT 138
             N++  +  GAF     L+RL L  N L       F G   L  LDLS NQ++A+    
Sbjct: 87  MENKISTIERGAFQDLKELERLRLNRNHLQLFPELLFLGTAKLYRLDLSENQIQAIPRKA 146

Query: 139 FAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHL 198
           F     ++NL L  N+++ +E  A  AL  L  L+L +N +  L+      +P L    L
Sbjct: 147 FRGAVDIKNLQLDYNQISCIEDGAFRALRDLEVLTLNNNNITRLSVASFNHMPKLRTFRL 206

Query: 199 RGNPWGCGCALRPLCAWLRRHP 220
             N   C C L  L  WLR+ P
Sbjct: 207 HSNNLYCDCHLAWLSDWLRQRP 228



 Score = 67.4 bits (163), Expect = 2e-11
 Identities = 59/221 (26%), Positives = 90/221 (40%), Gaps = 30/221 (13%)

Query: 43  CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDL 102
           CP  CTC+   +  CS   L  +P G+   +  L LD N+   L P   +    L  +DL
Sbjct: 727 CPTECTCLDT-VVRCSNKGLKVLPKGIPRDVTELYLDGNQF-TLVPKELSNYKHLTLIDL 784

Query: 103 RENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAA 162
             N + ++  ++F  +  L  L LS N+L  + P TF  L++LR LSL G          
Sbjct: 785 SNNRISTLSNQSFSNMTQLLTLILSYNRLRCIPPRTFDGLKSLRLLSLHG---------- 834

Query: 163 LGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLP 222
                         N+++ +  G    L AL  L +  NP  C C ++ L  W++     
Sbjct: 835 --------------NDISVVPEGAFNDLSALSHLAIGANPLYCDCNMQWLSDWVKSE--- 877

Query: 223 ASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDLA 263
             E     C  PG +    L       F+ C  P+ +  LA
Sbjct: 878 YKEPGIARCAGPGEMADKLLLTTPSKKFT-CQGPVDVNILA 917


>gi|194440719 chondroadherin-like [Homo sapiens]
          Length = 762

 Score =  103 bits (256), Expect = 3e-22
 Identities = 93/282 (32%), Positives = 122/282 (43%), Gaps = 17/282 (6%)

Query: 34  PSGSLGAPDCPEVCTCVPGGL-ASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFA 92
           P        CP  C CVP    +SC    L AVP G     + L L  N   ++P  AF 
Sbjct: 387 PGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGFPSDTQLLDLRRNHFPSVPRAAFP 446

Query: 93  GAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAG 152
           G G L  L L+  G+  +   A  GLG L  L LS NQL  L+         L  L L  
Sbjct: 447 GLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEGAPRLGYLYLER 506

Query: 153 NRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN---PWGCGCAL 209
           NR  ++  AAL ALP L SL LQDN +  LAPG LGR  AL  ++L GN       G AL
Sbjct: 507 NRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLG-AL 565

Query: 210 RPLCAWLRRH-------PLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQPLALRDL 262
            P     + H        +P    E +  +   +L+ +PL A  D AF    QP+  R L
Sbjct: 566 GPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAF----QPVG-RSL 620

Query: 263 AVVYTLGPASFLVSLASCLALGSGLTACRARRRRLRTAALRP 304
             ++        +   +   LG GL +   ++ +LR     P
Sbjct: 621 QHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALP 662



 Score = 93.2 bits (230), Expect = 3e-19
 Identities = 97/288 (33%), Positives = 118/288 (40%), Gaps = 46/288 (15%)

Query: 1   MRGPSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGL-ASCSA 59
           M GP  S   PL+L LL+L             +P+    A  CP+ C C       +C  
Sbjct: 1   MEGPRSSTHVPLVLPLLVL----------LLLAPARQAAAQRCPQACICDNSRRHVACRY 50

Query: 60  LSLPAVP---PGLSLRLRA---------------------LLLDHNRVRALPPGAFAGAG 95
            +L  VP   P L+ RL                       L L H  V  +  GAF G G
Sbjct: 51  QNLTEVPDAIPELTQRLDLQGNLLKVIPAAAFQGVPHLTHLDLRHCEVELVAEGAFRGLG 110

Query: 96  ALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRL 155
            L  L+L  N L  +   A  GLG+L+ L+L  N LE L PGTF  L AL  L+LA N L
Sbjct: 111 RLLLLNLASNHLRELPQEALDGLGSLRRLELEGNALEELRPGTFGALGALATLNLAHNAL 170

Query: 156 ARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN-----PWGCGCALR 210
             L   A   L  +R L L  N L+ LAP  L  LPAL  L L  N     P       R
Sbjct: 171 VYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGPVLSQAR 230

Query: 211 PLCAW-LRRHPLPASEAETVLCVWPGRLTL----SPLTAFSDAAFSHC 253
            L    L  +PL  +  E  L + PG   L      L A    AF+HC
Sbjct: 231 GLARLELGHNPLTYAGEEDGLAL-PGLRELLLDGGALQALGPRAFAHC 277



 Score = 85.9 bits (211), Expect = 5e-17
 Identities = 70/191 (36%), Positives = 85/191 (44%), Gaps = 6/191 (3%)

Query: 54  LASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVR 113
           LA  + + LPA+     LR+R L L HN +  L P A AG  AL+RL L  N L ++   
Sbjct: 165 LAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLHHNELQALPGP 224

Query: 114 AFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLS 173
                  L  L+L  N L          L  LR L L G  L  L P A    P L +L 
Sbjct: 225 VLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAFAHCPRLHTLD 284

Query: 174 LQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVW 233
           L+ N+L  L P  L     L  L L+GNP  CGC  RPL  WL R  + +  A    C  
Sbjct: 285 LRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRSDGA----CQG 338

Query: 234 PGRLTLSPLTA 244
           P RL    L A
Sbjct: 339 PRRLRGEALDA 349



 Score = 84.0 bits (206), Expect = 2e-16
 Identities = 61/151 (40%), Positives = 79/151 (52%), Gaps = 4/151 (2%)

Query: 68  GLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS 127
           G +  LR + L  NR+  +  GA   A  L++L L  N L  V   A  GL AL  L LS
Sbjct: 542 GRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLS 601

Query: 128 ANQLEALAPGTFAPL-RALRNLSLAGNRLARLEPAALGAL-PLLRSLSLQDNELAALAPG 185
            N L AL  G F P+ R+L++L L  + L ++ P A   L P L+SL LQ N+L AL   
Sbjct: 602 GNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPA- 660

Query: 186 LLGRLPALDALHLRGNPWGCGCALRPLCAWL 216
            L  L  L+ + L  NP+ C C L PL  WL
Sbjct: 661 -LPSLSQLELIDLSSNPFHCDCQLLPLHRWL 690


>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
          Length = 811

 Score =  102 bits (254), Expect = 5e-22
 Identities = 61/144 (42%), Positives = 77/144 (53%)

Query: 73  LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132
           L +L+L  N ++ L P  F     L  L LR N L  +   AFWGL AL+ L L  N+L 
Sbjct: 231 LSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLS 290

Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192
            L      PL +L  L L+GN L+ L PA  G L  LR LSL++N L+AL+  +    PA
Sbjct: 291 QLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPA 350

Query: 193 LDALHLRGNPWGCGCALRPLCAWL 216
           L  L L GN W C C LR L  W+
Sbjct: 351 LYRLDLDGNGWTCDCRLRGLKRWM 374



 Score = 86.7 bits (213), Expect = 3e-17
 Identities = 63/168 (37%), Positives = 78/168 (46%), Gaps = 4/168 (2%)

Query: 38  LGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLR----LRALLLDHNRVRALPPGAFAG 93
           L  P CPE C C       C+   L  VP   SL     +    L  N +  +    F  
Sbjct: 22  LAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHR 81

Query: 94  AGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGN 153
            G L+RLDL+ N + S+H + F  L  L+ L L  N L+ALAPGT APLR LR L   GN
Sbjct: 82  LGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGN 141

Query: 154 RLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201
            ++RL   +   L  L  L L  N L AL   +   L  L  LHL  N
Sbjct: 142 EISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESN 189


>gi|41582239 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  101 bits (251), Expect = 1e-21
 Identities = 71/207 (34%), Positives = 92/207 (44%), Gaps = 3/207 (1%)

Query: 40  APDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGA 96
           A  CPE C C       +A C+   L +VPPG    +  L L  NR+  LP GAF     
Sbjct: 16  AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPL 75

Query: 97  LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLA 156
           LQ L L  N + +V   A   L  L+ LDLS N +   A      L AL+ L +  N L 
Sbjct: 76  LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELT 135

Query: 157 RLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWL 216
            +   A  +L  LRSL L  N L  LA G    L AL  L +  NP+ C C +  L  W 
Sbjct: 136 FIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWA 195

Query: 217 RRHPLPASEAETVLCVWPGRLTLSPLT 243
               +   E + + C  P  L  +PL+
Sbjct: 196 LTTAVSIPEQDNIACTSPHVLKGTPLS 222


>gi|5031809 immunoglobulin superfamily containing leucine-rich
           repeat [Homo sapiens]
          Length = 428

 Score =  101 bits (251), Expect = 1e-21
 Identities = 71/207 (34%), Positives = 92/207 (44%), Gaps = 3/207 (1%)

Query: 40  APDCPEVCTCVPG---GLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGA 96
           A  CPE C C       +A C+   L +VPPG    +  L L  NR+  LP GAF     
Sbjct: 16  AQACPEPCDCGEKYGFQIADCAYRDLESVPPGFPANVTTLSLSANRLPGLPEGAFREVPL 75

Query: 97  LQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLA 156
           LQ L L  N + +V   A   L  L+ LDLS N +   A      L AL+ L +  N L 
Sbjct: 76  LQSLWLAHNEIRTVAAGALASLSHLKSLDLSHNLISDFAWSDLHNLSALQLLKMDSNELT 135

Query: 157 RLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWL 216
            +   A  +L  LRSL L  N L  LA G    L AL  L +  NP+ C C +  L  W 
Sbjct: 136 FIPRDAFRSLRALRSLQLNHNRLHTLAEGTFTPLTALSHLQINENPFDCTCGIVWLKTWA 195

Query: 217 RRHPLPASEAETVLCVWPGRLTLSPLT 243
               +   E + + C  P  L  +PL+
Sbjct: 196 LTTAVSIPEQDNIACTSPHVLKGTPLS 222


>gi|113423021 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score = 98.2 bits (243), Expect = 9e-21
 Identities = 79/194 (40%), Positives = 92/194 (47%), Gaps = 15/194 (7%)

Query: 73  LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS----- 127
           L AL L HN +  +  GAF G  +L  LDL  N L ++   AF GL AL+ L L+     
Sbjct: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351

Query: 128 -ANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL 186
               L A      APL  LR L LAGN L+RL PAAL  L  L  L ++ N LA L P  
Sbjct: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNALAGLDPDE 410

Query: 187 L------GRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240
           L      G LP    L L  NP  CGCA RPL AWLR       ++  + C  P  L   
Sbjct: 411 LRALERDGGLPG-PRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDR 469

Query: 241 PLTAFSDAAFSHCA 254
           PL    D A   CA
Sbjct: 470 PLLDL-DGARLRCA 482



 Score = 37.0 bits (84), Expect = 0.025
 Identities = 29/73 (39%), Positives = 33/73 (45%), Gaps = 7/73 (9%)

Query: 135 APGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALD 194
           A G   PL  L  L L  N +  +E  A   LP L +L L  N L AL  G    LPAL 
Sbjct: 284 AAGVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALR 341

Query: 195 ALHL-----RGNP 202
           +L L     RG P
Sbjct: 342 SLQLNHALVRGGP 354



 Score = 35.8 bits (81), Expect = 0.055
 Identities = 32/96 (33%), Positives = 40/96 (41%), Gaps = 13/96 (13%)

Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGA------------L 166
           G  +LL   A+  E   P    P  A RNL++ G  L  L  AA               L
Sbjct: 231 GGPKLLLRCASGAELRQPPRDVPPDA-RNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRL 289

Query: 167 PLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNP 202
           PLL +L L  N +  +  G    LP+L AL L  NP
Sbjct: 290 PLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325


>gi|113422497 PREDICTED: similar to hCG1820409 [Homo sapiens]
          Length = 578

 Score = 98.2 bits (243), Expect = 9e-21
 Identities = 79/194 (40%), Positives = 92/194 (47%), Gaps = 15/194 (7%)

Query: 73  LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLS----- 127
           L AL L HN +  +  GAF G  +L  LDL  N L ++   AF GL AL+ L L+     
Sbjct: 292 LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALRSLQLNHALVR 351

Query: 128 -ANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL 186
               L A      APL  LR L LAGN L+RL PAAL  L  L  L ++ N LA L P  
Sbjct: 352 GGPALLAALDAALAPLAELRLLGLAGNALSRLPPAAL-RLARLEQLDVRLNALAGLDPDE 410

Query: 187 L------GRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240
           L      G LP    L L  NP  CGCA RPL AWLR       ++  + C  P  L   
Sbjct: 411 LRALERDGGLPG-PRLLLADNPLRCGCAARPLLAWLRNATERVPDSRRLRCAAPRALLDR 469

Query: 241 PLTAFSDAAFSHCA 254
           PL    D A   CA
Sbjct: 470 PLLDL-DGARLRCA 482



 Score = 37.0 bits (84), Expect = 0.025
 Identities = 29/73 (39%), Positives = 33/73 (45%), Gaps = 7/73 (9%)

Query: 135 APGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALD 194
           A G   PL  L  L L  N +  +E  A   LP L +L L  N L AL  G    LPAL 
Sbjct: 284 AAGVRLPL--LSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNPLRALGGGAFRGLPALR 341

Query: 195 ALHL-----RGNP 202
           +L L     RG P
Sbjct: 342 SLQLNHALVRGGP 354



 Score = 35.8 bits (81), Expect = 0.055
 Identities = 32/96 (33%), Positives = 40/96 (41%), Gaps = 13/96 (13%)

Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGA------------L 166
           G  +LL   A+  E   P    P  A RNL++ G  L  L  AA               L
Sbjct: 231 GGPKLLLRCASGAELRQPPRDVPPDA-RNLTIVGANLTVLRAAAFAGGDGDGDQAAGVRL 289

Query: 167 PLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNP 202
           PLL +L L  N +  +  G    LP+L AL L  NP
Sbjct: 290 PLLSALRLTHNHIEVVEDGAFDGLPSLAALDLSHNP 325


>gi|225579152 insulin-like growth factor binding protein, acid
           labile subunit isoform 1 precursor [Homo sapiens]
          Length = 643

 Score = 97.4 bits (241), Expect = 2e-20
 Identities = 76/206 (36%), Positives = 97/206 (47%), Gaps = 8/206 (3%)

Query: 4   PSWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLG---APDCPEVCTCVPGGLAS---- 56
           P  S P   L L LLL  W      S   +  G+ G    P CP  C C     A     
Sbjct: 37  PQASPPAGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSV 96

Query: 57  -CSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAF 115
            CS+ +L  +P G+    +AL LD N + ++PP AF    +L  L+L+   L S+  +A 
Sbjct: 97  FCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQAL 156

Query: 116 WGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQ 175
            GL  L  L L  NQL +LA GTFA   AL +L L+ NRL+RLE      L  L  L+L 
Sbjct: 157 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 216

Query: 176 DNELAALAPGLLGRLPALDALHLRGN 201
            N LA L       L +L  L L GN
Sbjct: 217 WNSLAVLPDAAFRGLGSLRELVLAGN 242



 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 71/219 (32%), Positives = 96/219 (43%), Gaps = 37/219 (16%)

Query: 72  RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131
           +L +L L+ + +  + P  F G   L+RL L++NGL  +  ++ WGL  L  LDL++NQL
Sbjct: 425 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 484

Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL---LG 188
             L    F  L  L  L L+ NRLA L   ALG L     L +  N L AL   L   LG
Sbjct: 485 THLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 544

Query: 189 RL-----------------PALDALHLRGNPWGCGCALRPLCAWLRRHPL---------- 221
           RL                 P L+ L L GNPW CGC L+ L  +  ++P           
Sbjct: 545 RLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAIC 604

Query: 222 -------PASEAETVLCVWPGRLTLSPLTAFSDAAFSHC 253
                  PA     + C  P  +    L   S+A F+ C
Sbjct: 605 EGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 56/142 (39%), Positives = 71/142 (50%), Gaps = 4/142 (2%)

Query: 64  AVPPGLSLR----LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLG 119
           AV P  + R    LR L+L  NR+  L P  F+G   L+ LDL  N L ++    F  L 
Sbjct: 221 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 280

Query: 120 ALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNEL 179
            LQ L L  N + A+APG F  L+ALR L L+ NR+A L       L  LR L L  N +
Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340

Query: 180 AALAPGLLGRLPALDALHLRGN 201
           A+L P     L  L+ L L  N
Sbjct: 341 ASLRPRTFKDLHFLEELQLGHN 362



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 52/129 (40%), Positives = 69/129 (53%)

Query: 73  LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132
           L +L L +NR+  L  G F G G+L  L+L  N L  +   AF GLG+L+ L L+ N+L 
Sbjct: 186 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 245

Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192
            L P  F+ L  LR L L+ N L  ++      LP L+ L L  N +AA+APG    L A
Sbjct: 246 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 305

Query: 193 LDALHLRGN 201
           L  L L  N
Sbjct: 306 LRWLDLSHN 314



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 48/130 (36%), Positives = 67/130 (51%)

Query: 72  RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131
           RL+ L LD N + A+ PGAF G  AL+ LDL  N +  +    F GL  L++L LS N +
Sbjct: 281 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 340

Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLP 191
            +L P TF  L  L  L L  NR+ +L   +   L  L  L+L  N+L  +  G    L 
Sbjct: 341 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 400

Query: 192 ALDALHLRGN 201
            +  ++L GN
Sbjct: 401 NVAVMNLSGN 410



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 48/135 (35%), Positives = 66/135 (48%), Gaps = 1/135 (0%)

Query: 67  PGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDL 126
           PGL L LR L L HN + +L P  F     L+ L L  N +  +  R+F GLG L++L L
Sbjct: 325 PGL-LGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTL 383

Query: 127 SANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL 186
             NQL+ +  G F  L  +  ++L+GN L  L       L  L SL L+ + L  + P  
Sbjct: 384 DHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 443

Query: 187 LGRLPALDALHLRGN 201
              L  L  L L+ N
Sbjct: 444 FTGLSGLRRLFLKDN 458



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 49/129 (37%), Positives = 61/129 (47%)

Query: 73  LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132
           L  L L HNR+R L   +F G G L+ L L  N L  V   AF GL  + +++LS N L 
Sbjct: 354 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR 413

Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192
            L    F  L  L +L L G+ L R+ P     L  LR L L+DN L  +    L  L  
Sbjct: 414 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 473

Query: 193 LDALHLRGN 201
           L  L L  N
Sbjct: 474 LLELDLTSN 482



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 53/139 (38%), Positives = 67/139 (48%), Gaps = 1/139 (0%)

Query: 63  PAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQ 122
           PA+  GL+  LR L L  N +RA+    F     LQ+L L  N + +V   AF GL AL+
Sbjct: 249 PALFSGLA-ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 307

Query: 123 LLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAAL 182
            LDLS N++  L   TF  L  LR L L+ N +A L P     L  L  L L  N +  L
Sbjct: 308 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 367

Query: 183 APGLLGRLPALDALHLRGN 201
           A      L  L+ L L  N
Sbjct: 368 AERSFEGLGQLEVLTLDHN 386



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 47/117 (40%), Positives = 57/117 (48%), Gaps = 4/117 (3%)

Query: 76  LLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALA 135
           L L  N +  LP  AF G G+L+ L L  N L  +    F GL  L+ LDLS N L A+ 
Sbjct: 213 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 272

Query: 136 PGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALA----PGLLG 188
              F  L  L+ L L  N +A + P A   L  LR L L  N +A L     PGLLG
Sbjct: 273 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG 329



 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 50/146 (34%), Positives = 69/146 (47%), Gaps = 3/146 (2%)

Query: 62  LPAVPPGLSLRLRALL---LDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGL 118
           + AV PG  L L+AL    L HNRV  L    F G   L+ L L  N + S+  R F  L
Sbjct: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 351

Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNE 178
             L+ L L  N++  LA  +F  L  L  L+L  N+L  ++  A   L  +  ++L  N 
Sbjct: 352 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411

Query: 179 LAALAPGLLGRLPALDALHLRGNPWG 204
           L  L   +   L  L +LHL G+  G
Sbjct: 412 LRNLPEQVFRGLGKLHSLHLEGSCLG 437



 Score = 33.5 bits (75), Expect = 0.27
 Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 9/89 (10%)

Query: 62  LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121
           LPA   G   R   L + HNR+ ALP    A  G L+ L LR N L +   +       L
Sbjct: 511 LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGL 566

Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSL 150
           + L L  N  +        PL+ALR+ +L
Sbjct: 567 ERLWLEGNPWDC-----GCPLKALRDFAL 590


>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
          Length = 473

 Score = 97.1 bits (240), Expect = 2e-20
 Identities = 73/192 (38%), Positives = 92/192 (47%), Gaps = 4/192 (2%)

Query: 63  PAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQ 122
           PA   GL  RL  L LD   ++ L PG F G  ALQ L L++N L ++    F  LG L 
Sbjct: 123 PATFHGLG-RLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLT 181

Query: 123 LLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAAL 182
            L L  N++ ++    F  L +L  L L  NR+A + P A   L  L +L L  N L+AL
Sbjct: 182 HLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSAL 241

Query: 183 APGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPL 242
               L  L AL  L L  NPW C C  RPL AWL++    +SE   V C  P RL    L
Sbjct: 242 PTEALAPLRALQYLRLNDNPWVCDCRARPLWAWLQKFRGSSSE---VPCSLPQRLAGRDL 298

Query: 243 TAFSDAAFSHCA 254
              +      CA
Sbjct: 299 KRLAANDLQGCA 310



 Score = 85.5 bits (210), Expect = 6e-17
 Identities = 66/186 (35%), Positives = 79/186 (42%), Gaps = 11/186 (5%)

Query: 19  LSPWPVWAQVSATASPSGSLGAPDCPEVCTCV--PGGLASCSALSLPAVPPGLSLRLRAL 76
           L  W +W Q    A+P        CP  C C   P    SC    L AVP G+    + +
Sbjct: 11  LLAWVLWLQAWQVAAP--------CPGACVCYNEPKVTTSCPQQGLQAVPVGIPAASQRI 62

Query: 77  LLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSAN-QLEALA 135
            L  NR+  +P  +F     L  L L  N L  +   AF GL  L+ LDLS N QL ++ 
Sbjct: 63  FLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVD 122

Query: 136 PGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDA 195
           P TF  L  L  L L    L  L P     L  L+ L LQDN L AL       L  L  
Sbjct: 123 PATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTH 182

Query: 196 LHLRGN 201
           L L GN
Sbjct: 183 LFLHGN 188


>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
          Length = 420

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 68/182 (37%), Positives = 88/182 (48%), Gaps = 3/182 (1%)

Query: 72  RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131
           RL++L L   ++ +LP   F G  +LQ L L+EN L  +    F  L  L  L L  N+L
Sbjct: 132 RLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANLSHLFLHGNRL 191

Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLP 191
             L    F  L +L  L L GNRL  +  AA   L  L  L L +N LA+L    L  LP
Sbjct: 192 RLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLASLPGEALADLP 251

Query: 192 ALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAFS 251
           +L+ L L  NPW C C  RPL AW +R  + +S+   V C  P       L A  +A F 
Sbjct: 252 SLEFLRLNANPWACDCRARPLWAWFQRARVSSSD---VTCATPPERQGRDLRALREADFQ 308

Query: 252 HC 253
            C
Sbjct: 309 AC 310


>gi|10190722 leucine-rich repeats and transmembrane domains 1 [Homo
           sapiens]
          Length = 345

 Score = 96.7 bits (239), Expect = 3e-20
 Identities = 68/216 (31%), Positives = 96/216 (44%), Gaps = 3/216 (1%)

Query: 43  CPEVCTCVPG-GLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLD 101
           CP+ C C        CS   L  +P  L  + R L L  N++  LP  AF     L  L+
Sbjct: 21  CPDKCYCQSSTNFVDCSQQGLAEIPSHLPPQTRTLHLQDNQIHHLPAFAFRSVPWLMTLN 80

Query: 102 LRENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPA 161
           L  N L ++   AF GL  LQ+L+L+ N L +L    F  L  LR L L+ N ++ L P 
Sbjct: 81  LSNNSLSNLAPGAFHGLQHLQVLNLTQNSLLSLESRLFHSLPQLRELDLSSNNISHL-PT 139

Query: 162 ALGAL-PLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHP 220
           +LG     L  L++Q N+L  L   LL  +P++  L L+ N W C C L  L  WL +  
Sbjct: 140 SLGETWENLTILAVQQNQLQQLDRALLESMPSVRLLLLKDNLWKCNCHLLGLKLWLEKFV 199

Query: 221 LPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQP 256
                 + ++C  P       L       +  C  P
Sbjct: 200 YKGGLTDGIICESPDTWKGKDLLRIPHELYQPCPLP 235


>gi|194018474 leucine rich repeat containing 52 [Homo sapiens]
          Length = 313

 Score = 95.9 bits (237), Expect = 4e-20
 Identities = 77/269 (28%), Positives = 107/269 (39%), Gaps = 5/269 (1%)

Query: 17  LLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGLSLRLRAL 76
           L   P P W   S      G +    CP  C C    +  C+   L   P  + L  R L
Sbjct: 3   LASGPGPGWLLFSFGM---GLVSGSKCPNNCLCQAQEVI-CTGKQLTEYPLDIPLNTRRL 58

Query: 77  LLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALAP 136
            L+ NR+ +LP         L  LD + N +  V    F G+  L  LDLS+N L +++P
Sbjct: 59  FLNENRITSLPAMHLGLLSDLVYLDCQNNRIREVMDYTFIGVFKLIYLDLSSNNLTSISP 118

Query: 137 GTFAPLRALRNLSLAGN-RLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDA 195
            TF+ L  L  L++A N  L  L          LR L L++  L  L    L  L  L+ 
Sbjct: 119 FTFSVLSNLVQLNIANNPHLLSLHKFTFANTTSLRYLDLRNTGLQTLDSAALYHLTTLET 178

Query: 196 LHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLSPLTAFSDAAFSHCAQ 255
           L L GNPW C C+      +L    +  S+     CV P  LT  P+T   +     C  
Sbjct: 179 LFLSGNPWKCNCSFLDFAIFLIVFHMDPSDDLNATCVEPTELTGWPITRVGNPLRYMCIT 238

Query: 256 PLALRDLAVVYTLGPASFLVSLASCLALG 284
            L  +D   +  +G   F     +    G
Sbjct: 239 HLDHKDYIFLLLIGFCIFAAGTVAAWLTG 267


>gi|4826772 insulin-like growth factor binding protein, acid labile
           subunit isoform 2 precursor [Homo sapiens]
          Length = 605

 Score = 95.1 bits (235), Expect = 8e-20
 Identities = 73/197 (37%), Positives = 94/197 (47%), Gaps = 8/197 (4%)

Query: 13  LLLLLLLSPWPVWAQVSATASPSGSLG---APDCPEVCTCVPGGLAS-----CSALSLPA 64
           L L LLL  W      S   +  G+ G    P CP  C C     A      CS+ +L  
Sbjct: 8   LALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTR 67

Query: 65  VPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLL 124
           +P G+    +AL LD N + ++PP AF    +L  L+L+   L S+  +A  GL  L  L
Sbjct: 68  LPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHL 127

Query: 125 DLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAP 184
            L  NQL +LA GTFA   AL +L L+ NRL+RLE      L  L  L+L  N LA L  
Sbjct: 128 HLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPD 187

Query: 185 GLLGRLPALDALHLRGN 201
                L +L  L L GN
Sbjct: 188 AAFRGLGSLRELVLAGN 204



 Score = 92.0 bits (227), Expect = 6e-19
 Identities = 71/219 (32%), Positives = 96/219 (43%), Gaps = 37/219 (16%)

Query: 72  RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131
           +L +L L+ + +  + P  F G   L+RL L++NGL  +  ++ WGL  L  LDL++NQL
Sbjct: 387 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 446

Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL---LG 188
             L    F  L  L  L L+ NRLA L   ALG L     L +  N L AL   L   LG
Sbjct: 447 THLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLG 506

Query: 189 RL-----------------PALDALHLRGNPWGCGCALRPLCAWLRRHPL---------- 221
           RL                 P L+ L L GNPW CGC L+ L  +  ++P           
Sbjct: 507 RLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAIC 566

Query: 222 -------PASEAETVLCVWPGRLTLSPLTAFSDAAFSHC 253
                  PA     + C  P  +    L   S+A F+ C
Sbjct: 567 EGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 605



 Score = 77.4 bits (189), Expect = 2e-14
 Identities = 56/142 (39%), Positives = 71/142 (50%), Gaps = 4/142 (2%)

Query: 64  AVPPGLSLR----LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLG 119
           AV P  + R    LR L+L  NR+  L P  F+G   L+ LDL  N L ++    F  L 
Sbjct: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242

Query: 120 ALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNEL 179
            LQ L L  N + A+APG F  L+ALR L L+ NR+A L       L  LR L L  N +
Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302

Query: 180 AALAPGLLGRLPALDALHLRGN 201
           A+L P     L  L+ L L  N
Sbjct: 303 ASLRPRTFKDLHFLEELQLGHN 324



 Score = 74.3 bits (181), Expect = 1e-13
 Identities = 52/129 (40%), Positives = 69/129 (53%)

Query: 73  LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132
           L +L L +NR+  L  G F G G+L  L+L  N L  +   AF GLG+L+ L L+ N+L 
Sbjct: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207

Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192
            L P  F+ L  LR L L+ N L  ++      LP L+ L L  N +AA+APG    L A
Sbjct: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 267

Query: 193 LDALHLRGN 201
           L  L L  N
Sbjct: 268 LRWLDLSHN 276



 Score = 73.9 bits (180), Expect = 2e-13
 Identities = 48/130 (36%), Positives = 67/130 (51%)

Query: 72  RLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQL 131
           RL+ L LD N + A+ PGAF G  AL+ LDL  N +  +    F GL  L++L LS N +
Sbjct: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302

Query: 132 EALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLP 191
            +L P TF  L  L  L L  NR+ +L   +   L  L  L+L  N+L  +  G    L 
Sbjct: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362

Query: 192 ALDALHLRGN 201
            +  ++L GN
Sbjct: 363 NVAVMNLSGN 372



 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 48/135 (35%), Positives = 66/135 (48%), Gaps = 1/135 (0%)

Query: 67  PGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDL 126
           PGL L LR L L HN + +L P  F     L+ L L  N +  +  R+F GLG L++L L
Sbjct: 287 PGL-LGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTL 345

Query: 127 SANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGL 186
             NQL+ +  G F  L  +  ++L+GN L  L       L  L SL L+ + L  + P  
Sbjct: 346 DHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 405

Query: 187 LGRLPALDALHLRGN 201
              L  L  L L+ N
Sbjct: 406 FTGLSGLRRLFLKDN 420



 Score = 69.3 bits (168), Expect = 4e-12
 Identities = 49/129 (37%), Positives = 61/129 (47%)

Query: 73  LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132
           L  L L HNR+R L   +F G G L+ L L  N L  V   AF GL  + +++LS N L 
Sbjct: 316 LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLR 375

Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192
            L    F  L  L +L L G+ L R+ P     L  LR L L+DN L  +    L  L  
Sbjct: 376 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 435

Query: 193 LDALHLRGN 201
           L  L L  N
Sbjct: 436 LLELDLTSN 444



 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 53/139 (38%), Positives = 67/139 (48%), Gaps = 1/139 (0%)

Query: 63  PAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQ 122
           PA+  GL+  LR L L  N +RA+    F     LQ+L L  N + +V   AF GL AL+
Sbjct: 211 PALFSGLA-ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 269

Query: 123 LLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAAL 182
            LDLS N++  L   TF  L  LR L L+ N +A L P     L  L  L L  N +  L
Sbjct: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 329

Query: 183 APGLLGRLPALDALHLRGN 201
           A      L  L+ L L  N
Sbjct: 330 AERSFEGLGQLEVLTLDHN 348



 Score = 66.2 bits (160), Expect = 4e-11
 Identities = 47/117 (40%), Positives = 57/117 (48%), Gaps = 4/117 (3%)

Query: 76  LLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLEALA 135
           L L  N +  LP  AF G G+L+ L L  N L  +    F GL  L+ LDLS N L A+ 
Sbjct: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234

Query: 136 PGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALA----PGLLG 188
              F  L  L+ L L  N +A + P A   L  LR L L  N +A L     PGLLG
Sbjct: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG 291



 Score = 62.0 bits (149), Expect = 7e-10
 Identities = 50/146 (34%), Positives = 69/146 (47%), Gaps = 3/146 (2%)

Query: 62  LPAVPPGLSLRLRALL---LDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGL 118
           + AV PG  L L+AL    L HNRV  L    F G   L+ L L  N + S+  R F  L
Sbjct: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313

Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNE 178
             L+ L L  N++  LA  +F  L  L  L+L  N+L  ++  A   L  +  ++L  N 
Sbjct: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373

Query: 179 LAALAPGLLGRLPALDALHLRGNPWG 204
           L  L   +   L  L +LHL G+  G
Sbjct: 374 LRNLPEQVFRGLGKLHSLHLEGSCLG 399



 Score = 33.5 bits (75), Expect = 0.27
 Identities = 30/89 (33%), Positives = 40/89 (44%), Gaps = 9/89 (10%)

Query: 62  LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121
           LPA   G   R   L + HNR+ ALP    A  G L+ L LR N L +   +       L
Sbjct: 473 LPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGL 528

Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSL 150
           + L L  N  +        PL+ALR+ +L
Sbjct: 529 ERLWLEGNPWDC-----GCPLKALRDFAL 552


>gi|88702793 slit-like 2 [Homo sapiens]
          Length = 673

 Score = 95.1 bits (235), Expect = 8e-20
 Identities = 71/188 (37%), Positives = 86/188 (45%), Gaps = 16/188 (8%)

Query: 11  PLLL-LLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLASCSALSLPAVPPGL 69
           PLLL LLLLL+  P               G   CP  C C       C+A     VP  +
Sbjct: 6   PLLLPLLLLLALGP---------------GVQGCPSGCQCSQPQTVFCTARQGTTVPRDV 50

Query: 70  SLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSAN 129
                 L +  N +  L  G+FAG   LQ LDL +N + S+    F  L  L  LDL+AN
Sbjct: 51  PPDTVGLYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTAN 110

Query: 130 QLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGR 189
           +L  +   TF  LR L  L L  NR+  ++P A   L  L  L LQDNEL AL P  L R
Sbjct: 111 RLHEITNETFRGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPPLRLPR 170

Query: 190 LPALDALH 197
           L  LD  H
Sbjct: 171 LLLLDLSH 178



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 90/265 (33%), Positives = 108/265 (40%), Gaps = 22/265 (8%)

Query: 62  LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGAL 121
           L A+PP    RL  L L HN + AL PG    A  ++ L L   GL  +    F  L  L
Sbjct: 160 LRALPPLRLPRLLLLDLSHNSLLALEPGILDTAN-VEALRLAGLGLQQLDEGLFSRLRNL 218

Query: 122 QLLDLSANQLEALAPGTFAPLRALRNLSLAGN-RLARLEPAALGALPLLRSLSLQDNELA 180
             LD+S NQLE + P     LR L  L LAGN R+A+L P  L  L  L+ L + +  L 
Sbjct: 219 HDLDVSDNQLERVPP-VIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSNLSLQ 277

Query: 181 ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWP----GR 236
           AL   L G  P L  L    NP+ C C L     W+R   +  +  E   C +P    GR
Sbjct: 278 ALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCHFPPKNAGR 337

Query: 237 LTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSGLTACRARRRR 296
           L L       D A   C    A    A V T  P      +    AL S L         
Sbjct: 338 LLLE-----LDYADFGCP---ATTTTATVPTTRPV-----VREPTALSSSLAPTWLSPTE 384

Query: 297 LRTAALRPP--RPPDPNPDPDPHGC 319
             T A  PP   PP   P P P  C
Sbjct: 385 PATEAPSPPSTAPPTVGPVPQPQDC 409


>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
          Length = 560

 Score = 92.8 bits (229), Expect = 4e-19
 Identities = 68/184 (36%), Positives = 85/184 (46%), Gaps = 1/184 (0%)

Query: 62  LPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENG-LHSVHVRAFWGLGA 120
           LP V  G    L+ L L+  ++R LP  AF     L+ L +  +  L ++   AF GLG 
Sbjct: 281 LPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGE 340

Query: 121 LQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELA 180
           LQ+L L +N L AL  G    L  LR +SL  NRL  L  A    L  L S+ L  N+L 
Sbjct: 341 LQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLE 400

Query: 181 ALAPGLLGRLPALDALHLRGNPWGCGCALRPLCAWLRRHPLPASEAETVLCVWPGRLTLS 240
            L   + G LP L  + L  N W C C L P   WLR+H       E   C  PG     
Sbjct: 401 TLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGL 460

Query: 241 PLTA 244
           PL A
Sbjct: 461 PLWA 464



 Score = 75.5 bits (184), Expect = 6e-14
 Identities = 72/214 (33%), Positives = 89/214 (41%), Gaps = 28/214 (13%)

Query: 73  LRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQLE 132
           L  L LDHN +R +    F     LQ L L +N L  +    F  L  L+LLDLS N L 
Sbjct: 124 LEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLT 183

Query: 133 ALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPA 192
            L  G       L  L L  NRL  L+   L +L  L  L    N + ++APG   RLP 
Sbjct: 184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPN 243

Query: 193 LDALHLRGNPWGCGCALRPLCAWLRRHPL--------PASEAETVLC--------VWPGR 236
           L +L L  N      A  P   +L  H L        P +E   VL         +W  R
Sbjct: 244 LSSLTLSRN----HLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR 299

Query: 237 LTLSPLTAFSDAAFSHCAQPLALRDLAVVYTLGP 270
             L  L A   AAF + ++   LR L V  TL P
Sbjct: 300 TQLRTLPA---AAFRNLSR---LRYLGV--TLSP 325



 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 51/143 (35%), Positives = 65/143 (45%), Gaps = 3/143 (2%)

Query: 62  LPAVPPGLS---LRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGL 118
           + AV PG     ++L+ L L  N++  LP         L++L L  N L  +    F  L
Sbjct: 86  ISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKL 145

Query: 119 GALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNE 178
             LQ L L+ NQL+ L    F  L  L+ L L+GN L  L    LGA   L  L L  N 
Sbjct: 146 VNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNR 205

Query: 179 LAALAPGLLGRLPALDALHLRGN 201
           L +L  GLL  L AL  L    N
Sbjct: 206 LVSLDSGLLNSLGALTELQFHRN 228



 Score = 60.5 bits (145), Expect = 2e-09
 Identities = 51/159 (32%), Positives = 68/159 (42%), Gaps = 23/159 (14%)

Query: 43  CPEVCTCVPGGLASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDL 102
           CP  C CV    A CS         G   R+ AL L  N    L  G   G G LQ    
Sbjct: 21  CPPACKCVFRDAAQCSG--------GDVARISALGLPTNLTHILLFGM--GRGVLQS--- 67

Query: 103 RENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAA 162
                     ++F G+  LQ L +S + + A+APGTF+ L  L+ L L+ N++  L  A 
Sbjct: 68  ----------QSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGAL 117

Query: 163 LGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGN 201
           L  + LL  L L  N L  +   +  +L  L  L L  N
Sbjct: 118 LDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQN 156



 Score = 57.8 bits (138), Expect = 1e-08
 Identities = 74/241 (30%), Positives = 100/241 (41%), Gaps = 23/241 (9%)

Query: 71  LRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQLLDLSANQ 130
           + L+ L L+ N++  LP   F     L+ LDL  N L  +          L+ L L +N+
Sbjct: 146 VNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNR 205

Query: 131 LEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRL 190
           L +L  G    L AL  L    N +  + P A   LP L SL+L  N LA L   L    
Sbjct: 206 LVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHS 265

Query: 191 PALDALHLRGNP--------WGCGCALRPLCAWLRR---HPLPASEAETVLCVWPGRLTL 239
             L  L L  NP        +G    L+ L  WL R     LPA+    +  +    +TL
Sbjct: 266 HNLTLLTLFENPLAELPGVLFGEMGGLQEL--WLNRTQLRTLPAAAFRNLSRLRYLGVTL 323

Query: 240 SP-LTAFSDAAFSHCAQPLALRDLAVVYTLGPASFLVSLASCLALGSG-LTACRARRRRL 297
           SP L+A    AF    Q L    +  +++ G    L +L   L  G G L     RR RL
Sbjct: 324 SPRLSALPQGAF----QGLGELQVLALHSNG----LTALPDGLLRGLGKLRQVSLRRNRL 375

Query: 298 R 298
           R
Sbjct: 376 R 376



 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 48/152 (31%), Positives = 61/152 (40%), Gaps = 3/152 (1%)

Query: 54  LASCSALSLPAVPPGL---SLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSV 110
           L   S  +L  +P GL     +L  LLL  NR+ +L  G     GAL  L    N + S+
Sbjct: 174 LLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSI 233

Query: 111 HVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLR 170
              AF  L  L  L LS N L  L    F     L  L+L  N LA L     G +  L+
Sbjct: 234 APGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQ 293

Query: 171 SLSLQDNELAALAPGLLGRLPALDALHLRGNP 202
            L L   +L  L       L  L  L +  +P
Sbjct: 294 ELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSP 325


>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
           sapiens]
          Length = 593

 Score = 92.8 bits (229), Expect = 4e-19
 Identities = 72/195 (36%), Positives = 87/195 (44%), Gaps = 18/195 (9%)

Query: 5   SWSRPRPLLLLLLLLSPWPVWAQVSATASPSGSLGAPDCPEVCTCVPGGLAS-CSALSLP 63
           +W    PLL LLLL               P GS G+  CP VC C     A  C    L 
Sbjct: 10  AWPPWPPLLFLLLL---------------PGGSGGS--CPAVCDCTSQPQAVLCGHRQLE 52

Query: 64  AVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLRENGLHSVHVRAFWGLGALQL 123
           AVP GL L    L L  NR+  L  G  +    LQ LDL  N L ++   AF GL +L  
Sbjct: 53  AVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLT 112

Query: 124 LDLSANQLEALAPGTFAPLRALRNLSLAGNRLARLEPAALGALPLLRSLSLQDNELAALA 183
           L L  N+L  + PG F+ L AL  L L  N++      A G L  L+ L + DN L  +A
Sbjct: 113 LRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVA 172

Query: 184 PGLLGRLPALDALHL 198
           PG    L  L  L L
Sbjct: 173 PGAFAGLAKLSTLTL 187



 Score = 63.2 bits (152), Expect = 3e-10
 Identities = 57/190 (30%), Positives = 78/190 (41%), Gaps = 30/190 (15%)

Query: 54  LASCSALSLPAVPPGLSLRLRALLLDHNRVRALPPGAFAGAGALQRLDLR---------- 103
           L++   L+L  +P  ++LRLR L      +  LP GA  G G L+ L++           
Sbjct: 192 LSTVPGLALARLPALVALRLREL-----DIGRLPAGALRGLGQLKELEIHLWPSLEALDP 246

Query: 104 --------------ENGLHSVHVRAFWGLGALQLLDLSANQLEALAPGTFAPLRALRNLS 149
                            L SV  +A + L  L++LDLS N + A+     +PL  L+ L 
Sbjct: 247 GSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELR 306

Query: 150 LAGNRLARLEPAALGALPLLRSLSLQDNELAALAPGLLGRLPALDALHLRGNPWGCGCAL 209
           L+G  L  +   A   L     L + DN L  L          L  L L GNP  C C L
Sbjct: 307 LSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPLTCDCRL 366

Query: 210 RPLCAWLRRH 219
             L   LRRH
Sbjct: 367 LWLLR-LRRH 375


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.137    0.444 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,604,603
Number of Sequences: 37866
Number of extensions: 946262
Number of successful extensions: 9181
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 247
Number of HSP's successfully gapped in prelim test: 182
Number of HSP's that attempted gapping in prelim test: 6927
Number of HSP's gapped (non-prelim): 1412
length of query: 334
length of database: 18,247,518
effective HSP length: 103
effective length of query: 231
effective length of database: 14,347,320
effective search space: 3314230920
effective search space used: 3314230920
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.