BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo sapiens] (464 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 954 0.0 gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 561 e-160 gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 561 e-160 gi|7657152 hect domain and RLD 3 [Homo sapiens] 122 5e-28 gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 120 2e-27 gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 120 2e-27 gi|61563742 hect domain and RLD 6 [Homo sapiens] 105 9e-23 gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 102 7e-22 gi|4557445 regulator of chromosome condensation and BTB domain c... 100 2e-21 gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 93 6e-19 gi|126032348 hect domain and RLD 2 [Homo sapiens] 90 4e-18 gi|110825982 hect domain and RLD 5 [Homo sapiens] 90 5e-18 gi|114796646 regulator of chromosome condensation 1 isoform b [H... 87 2e-17 gi|114796644 regulator of chromosome condensation 1 isoform a [H... 87 2e-17 gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 87 2e-17 gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 87 2e-17 gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 87 2e-17 gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 87 2e-17 gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 84 4e-16 gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 84 4e-16 gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 82 8e-16 gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 82 8e-16 gi|6912330 deafness locus associated putative guanine nucleotide... 80 3e-15 gi|222136641 NIMA-related kinase 9 [Homo sapiens] 71 2e-12 gi|30039692 NIMA-related kinase 8 [Homo sapiens] 64 4e-10 gi|63054860 RCC1 domain containing 1 [Homo sapiens] 62 1e-09 gi|63054858 RCC1 domain containing 1 [Homo sapiens] 62 1e-09 gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens] 59 1e-08 gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 54 3e-07 gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 53 7e-07 >gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo sapiens] Length = 464 Score = 954 bits (2466), Expect = 0.0 Identities = 464/464 (100%), Positives = 464/464 (100%) Query: 1 MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADR 60 MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADR Sbjct: 1 MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADR 60 Query: 61 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL Sbjct: 61 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120 Query: 121 LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS 180 LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS Sbjct: 121 LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS 180 Query: 181 CGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQD 240 CGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQD Sbjct: 181 CGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQD 240 Query: 241 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 300 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA Sbjct: 241 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 300 Query: 301 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW Sbjct: 301 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360 Query: 361 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK 420 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK Sbjct: 361 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK 420 Query: 421 NIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI 464 NIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI Sbjct: 421 NIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI 464 >gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo sapiens] Length = 267 Score = 561 bits (1445), Expect = e-160 Identities = 266/267 (99%), Positives = 266/267 (99%) Query: 198 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 257 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG Sbjct: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60 Query: 258 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 317 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120 Query: 318 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 377 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180 Query: 378 EMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437 EMIPPTLFGLTEFNPEIQVSRIRCGLS FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240 Query: 438 WRVTMPGEPVDVACGVDHMVTLAKSFI 464 WRVTMPGEPVDVACGVDHMVTLAKSFI Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267 Score = 58.9 bits (141), Expect = 9e-09 Identities = 63/206 (30%), Positives = 93/206 (45%), Gaps = 26/206 (12%) Query: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVV 233 +V+QV+CG+ HSL LTD+ V+S G + GQ G + I S ++ D G V+ Sbjct: 34 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTG--LGHYNITSSPTKLG--GDLAGVNVI 89 Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS-----PTKLGGDLAGVNVIQV 288 QVA D L ++ G ++ GWG L ++T S P L G V Q Sbjct: 90 QVATYGDCCLAVSADGGLF--GWGNSEYLQLA--SVTDSTQVNVPRCLHFSGVG-KVRQA 144 Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--------HFSGVGKVRQ 340 A G C ++ +G +F WG Y L + + VP + F+ +V + Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201 Query: 341 AACGGTGCAVLNGEGHVFVWGYGILG 366 CG + A L +G +FVWG I G Sbjct: 202 IRCGLSRFAALTNKGELFVWGKNIRG 227 Score = 34.7 bits (78), Expect = 0.19 Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 19/140 (13%) Query: 108 KISSAACG-YGFTLLSSKTADVTKVWGMG-LNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165 K+ AACG G +L+ + VWG G L K L ++ P+ Sbjct: 140 KVRQAACGGTGCAVLNGEGH--VFVWGYGILGKGPNL--------VESAVPEMIPPTLFG 189 Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225 L P E +V ++ CG + LT++ +F G N G G +E++ + RV Sbjct: 190 LTEFNP-EIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF--PWRV--- 243 Query: 226 QDFDGQVVQVACGQDHSLFL 245 G+ V VACG DH + L Sbjct: 244 -TMPGEPVDVACGVDHMVTL 262 >gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo sapiens] Length = 267 Score = 561 bits (1445), Expect = e-160 Identities = 266/267 (99%), Positives = 266/267 (99%) Query: 198 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 257 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG Sbjct: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60 Query: 258 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 317 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120 Query: 318 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 377 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180 Query: 378 EMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437 EMIPPTLFGLTEFNPEIQVSRIRCGLS FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240 Query: 438 WRVTMPGEPVDVACGVDHMVTLAKSFI 464 WRVTMPGEPVDVACGVDHMVTLAKSFI Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267 Score = 58.9 bits (141), Expect = 9e-09 Identities = 63/206 (30%), Positives = 93/206 (45%), Gaps = 26/206 (12%) Query: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVV 233 +V+QV+CG+ HSL LTD+ V+S G + GQ G + I S ++ D G V+ Sbjct: 34 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTG--LGHYNITSSPTKLG--GDLAGVNVI 89 Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS-----PTKLGGDLAGVNVIQV 288 QVA D L ++ G ++ GWG L ++T S P L G V Q Sbjct: 90 QVATYGDCCLAVSADGGLF--GWGNSEYLQLA--SVTDSTQVNVPRCLHFSGVG-KVRQA 144 Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--------HFSGVGKVRQ 340 A G C ++ +G +F WG Y L + + VP + F+ +V + Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201 Query: 341 AACGGTGCAVLNGEGHVFVWGYGILG 366 CG + A L +G +FVWG I G Sbjct: 202 IRCGLSRFAALTNKGELFVWGKNIRG 227 Score = 34.7 bits (78), Expect = 0.19 Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 19/140 (13%) Query: 108 KISSAACG-YGFTLLSSKTADVTKVWGMG-LNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165 K+ AACG G +L+ + VWG G L K L ++ P+ Sbjct: 140 KVRQAACGGTGCAVLNGEGH--VFVWGYGILGKGPNL--------VESAVPEMIPPTLFG 189 Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225 L P E +V ++ CG + LT++ +F G N G G +E++ + RV Sbjct: 190 LTEFNP-EIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF--PWRV--- 243 Query: 226 QDFDGQVVQVACGQDHSLFL 245 G+ V VACG DH + L Sbjct: 244 -TMPGEPVDVACGVDHMVTL 262 >gi|7657152 hect domain and RLD 3 [Homo sapiens] Length = 1050 Score = 122 bits (307), Expect = 5e-28 Identities = 83/239 (34%), Positives = 118/239 (49%), Gaps = 16/239 (6%) Query: 229 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288 D V +VACG +HS+FL + GEVY+CG GQ LGH + P ++G LA ++I V Sbjct: 33 DRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQ--LGHEREGNKPEQIGA-LADQHIIHV 89 Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 348 A LA+S G LF WG QL +T V VPR + + Q +CG C Sbjct: 90 ACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHC 149 Query: 349 AVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSH 405 L +G F WG +G LG G A P+ + +L G I ++++ G +H Sbjct: 150 LALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRV-RSLEG-------IPLAQVAAGGAH 201 Query: 406 FAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM--PGEPVDVACGVDHMVTLAKS 462 AL+ G +F WG N G LG+ +D+ P V + + V ++CG +H L KS Sbjct: 202 SFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKS 260 Score = 112 bits (281), Expect = 5e-25 Identities = 98/328 (29%), Positives = 152/328 (46%), Gaps = 34/328 (10%) Query: 106 DQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165 D+ + ACG ++ + +V + GLN QLG R +P + Sbjct: 33 DRSVKEVACGGNHSVFLLEDGEV---YTCGLNTKGQLGHEREGN----------KPEQIG 79 Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225 D+ ++ V+CG +HSL L+DR +FS G S GQ G E+ + V R+ Sbjct: 80 ALADQ----HIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSV-----AVPRL 130 Query: 226 -QDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLG-HYNITSSPTKLGGDLAG 282 Q + Q ++QV+CG H L L G+ ++ G + GQ GLG + +SP ++ L G Sbjct: 131 IQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRV-RSLEG 189 Query: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342 + + QVA G A+S G +FGWG + QL ++D P + KV + Sbjct: 190 IPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQL-GLSDEKDRESPCHVKLLRTQKVVYIS 248 Query: 343 CGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 402 CG AVL G VF +G G G+ + +S E+ P + L +V++I CG Sbjct: 249 CGEEHTAVLTKSGGVFTFGAGSCGQLGH--DSMNDEVNPRRVLELM----GSEVTQIACG 302 Query: 403 LSH-FAALTNKGELFVWGKNIRGCLGIG 429 H A + + G ++ +G RG LG G Sbjct: 303 RQHTLAFVPSSGLIYAFGCGARGQLGTG 330 Score = 80.9 bits (198), Expect = 2e-15 Identities = 68/218 (31%), Positives = 100/218 (45%), Gaps = 34/218 (15%) Query: 62 FVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLL 121 F WG + G LG+ PS R R ++ +P L Q + A + +L Sbjct: 159 FTWGKNSHGQLGLGK-EFPSQASPQRV-----RSLEGIP----LAQVAAGGAHSFALSLS 208 Query: 122 SSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSC 181 + V+G G+N QLG KD+ SP + L R Q +V+ +SC Sbjct: 209 GA-------VFGWGMNNAGQLGLS-DEKDRE---------SPCHVKLLRTQ--KVVYISC 249 Query: 182 GRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDH 241 G H+ VLT GVF+ G S GQ G + +E+ RV ++ +V Q+ACG+ H Sbjct: 250 GEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEV--NPRRV--LELMGSEVTQIACGRQH 305 Query: 242 SL-FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGG 278 +L F+ G +Y+ G GA GQ G GH P+ + G Sbjct: 306 TLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343 Score = 52.8 bits (125), Expect = 7e-07 Identities = 39/137 (28%), Positives = 58/137 (42%), Gaps = 11/137 (8%) Query: 327 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFG 386 P+ F V++ ACGG L +G V+ G G+ + E PE I Sbjct: 25 PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL--- 81 Query: 387 LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP 446 + + + CG SH AL+++G+LF WG G LG+ ED R+ Sbjct: 82 -----ADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQ 136 Query: 447 ---VDVACGVDHMVTLA 460 + V+CG H + LA Sbjct: 137 QTILQVSCGNWHCLALA 153 Score = 41.2 bits (95), Expect = 0.002 Identities = 32/111 (28%), Positives = 47/111 (42%), Gaps = 24/111 (21%) Query: 360 WGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419 WGY LG+ P + + + P + G F + V + CG +H L GE++ G Sbjct: 4 WGYWSLGQ-PGISTNLQGIVAEPQVCG---FISDRSVKEVACGGNHSVFLLEDGEVYTCG 59 Query: 420 KNIRGCLG----------IGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLA 460 N +G LG IG L DQ+ + VACG H + L+ Sbjct: 60 LNTKGQLGHEREGNKPEQIGALADQHI----------IHVACGESHSLALS 100 >gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] Length = 1049 Score = 120 bits (302), Expect = 2e-27 Identities = 106/348 (30%), Positives = 154/348 (44%), Gaps = 28/348 (8%) Query: 105 LDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPV 164 +++++ CG T+ D V+ G N QLG +SRK +P V Sbjct: 32 INKRVRDVGCGLRHTVF---VLDDGTVYTCGCNDLGQLGHEKSRK----------KPEQV 78 Query: 165 SLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHR 224 + LD ++ VSCG AH+L L D+ V++ G +S GQ G V E + Sbjct: 79 -VALDAQN---IVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL-VGSEECIRVPRNIKS 133 Query: 225 MQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284 + D Q+VQVACG HSL L+ EV+ G GQ GLG + +L L G+ Sbjct: 134 LSDI--QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIP 191 Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344 +QVA G ++ G +FGWG +++ QL + D VP L K+ CG Sbjct: 192 FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GLNDENDRYVPNLLKSLRSQKIVYICCG 250 Query: 345 GTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLS 404 A L EG VF +G G G G S E+ P +F L V+ I CG Sbjct: 251 EDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHEINPRKVFELM----GSIVTEIACGRQ 304 Query: 405 HFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVAC 451 H +A + + G ++ +G G LG G ++ P+ V P + C Sbjct: 305 HTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQC 352 Score = 108 bits (269), Expect = 1e-23 Identities = 86/270 (31%), Positives = 126/270 (46%), Gaps = 22/270 (8%) Query: 199 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 256 GN S+GQ G ++ EI E R DF + +V V CG H++F+ D G VY+CG Sbjct: 5 GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60 Query: 257 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 316 GQ LGH P ++ L N++ V+ LA++ G ++ WG QL Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117 Query: 317 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 373 V + VPR + ++ Q ACG L+ VF WG YG LG G + + Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177 Query: 374 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLED 433 P+++ +L G+ P +QV+ G +H LT G +F WG+N G LG+ D Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229 Query: 434 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 461 +Y P + + V + CG DH L K Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259 Score = 73.2 bits (178), Expect = 5e-13 Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 40/228 (17%) Query: 56 ARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACG 115 ++A VF WG + G LG+ + + P + + + +P+ Q + A Sbjct: 153 SKASEVFCWGQNKYGQLGLGTDCKKQTSP------QLLKSLLGIPFM----QVAAGGAHS 202 Query: 116 YGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETR 175 + TL + ++G G NK QLG + D+ Y V L + + Sbjct: 203 FVLTLSGA-------IFGWGRNKFGQLGLN----DENDRY--------VPNLLKSLRSQK 243 Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD--GQVV 233 ++ + CG H+ LT GVF+ G YGQ G S SH ++ + F+ G +V Sbjct: 244 IVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN-------STSHEINPRKVFELMGSIV 296 Query: 234 -QVACGQDH-SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279 ++ACG+ H S F+ G +YS G G +GQ G G + SP + G+ Sbjct: 297 TEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGN 344 >gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] Length = 1057 Score = 120 bits (302), Expect = 2e-27 Identities = 106/348 (30%), Positives = 154/348 (44%), Gaps = 28/348 (8%) Query: 105 LDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPV 164 +++++ CG T+ D V+ G N QLG +SRK +P V Sbjct: 32 INKRVRDVGCGLRHTVF---VLDDGTVYTCGCNDLGQLGHEKSRK----------KPEQV 78 Query: 165 SLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHR 224 + LD ++ VSCG AH+L L D+ V++ G +S GQ G V E + Sbjct: 79 -VALDAQN---IVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL-VGSEECIRVPRNIKS 133 Query: 225 MQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284 + D Q+VQVACG HSL L+ EV+ G GQ GLG + +L L G+ Sbjct: 134 LSDI--QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIP 191 Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344 +QVA G ++ G +FGWG +++ QL + D VP L K+ CG Sbjct: 192 FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GLNDENDRYVPNLLKSLRSQKIVYICCG 250 Query: 345 GTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLS 404 A L EG VF +G G G G S E+ P +F L V+ I CG Sbjct: 251 EDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHEINPRKVFELM----GSIVTEIACGRQ 304 Query: 405 HFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVAC 451 H +A + + G ++ +G G LG G ++ P+ V P + C Sbjct: 305 HTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQC 352 Score = 108 bits (269), Expect = 1e-23 Identities = 86/270 (31%), Positives = 126/270 (46%), Gaps = 22/270 (8%) Query: 199 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 256 GN S+GQ G ++ EI E R DF + +V V CG H++F+ D G VY+CG Sbjct: 5 GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60 Query: 257 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 316 GQ LGH P ++ L N++ V+ LA++ G ++ WG QL Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117 Query: 317 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 373 V + VPR + ++ Q ACG L+ VF WG YG LG G + + Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177 Query: 374 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLED 433 P+++ +L G+ P +QV+ G +H LT G +F WG+N G LG+ D Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229 Query: 434 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 461 +Y P + + V + CG DH L K Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259 Score = 73.2 bits (178), Expect = 5e-13 Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 40/228 (17%) Query: 56 ARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACG 115 ++A VF WG + G LG+ + + P + + + +P+ Q + A Sbjct: 153 SKASEVFCWGQNKYGQLGLGTDCKKQTSP------QLLKSLLGIPFM----QVAAGGAHS 202 Query: 116 YGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETR 175 + TL + ++G G NK QLG + D+ Y V L + + Sbjct: 203 FVLTLSGA-------IFGWGRNKFGQLGLN----DENDRY--------VPNLLKSLRSQK 243 Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD--GQVV 233 ++ + CG H+ LT GVF+ G YGQ G S SH ++ + F+ G +V Sbjct: 244 IVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN-------STSHEINPRKVFELMGSIV 296 Query: 234 -QVACGQDH-SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279 ++ACG+ H S F+ G +YS G G +GQ G G + SP + G+ Sbjct: 297 TEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGN 344 >gi|61563742 hect domain and RLD 6 [Homo sapiens] Length = 1022 Score = 105 bits (262), Expect = 9e-23 Identities = 85/283 (30%), Positives = 130/283 (45%), Gaps = 12/283 (4%) Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ- 234 +LQ + G HSL+L V S G+NS GQ GR+ + E +Q + +V Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEP-----IQALETLIVDL 79 Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294 V+CG++HSL + KG V++ G G++GQ G+G + S K L + +IQV+ Sbjct: 80 VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139 Query: 295 CLAVSADGGLFGWGNSEYLQLASVTD-STQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353 LA+S D +F WG + + QL + +Q + R G+ + Q A GG L+ Sbjct: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGI-PLAQVAAGGAHSFALSL 198 Query: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413 G F WG G+ + + P G + + V I CG +H A LT G Sbjct: 199 CGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALK---NLGVVYISCGDAHTAVLTQDG 255 Query: 414 ELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVDVACGVDH 455 ++F +G N G LG ++ P V + G + CG H Sbjct: 256 KVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYH 298 Score = 63.9 bits (154), Expect = 3e-10 Identities = 94/348 (27%), Positives = 143/348 (41%), Gaps = 47/348 (13%) Query: 26 WTAARRSRSRREAAEAEAEVPVVQYVGERAARA----DRVFVWGFSFSGALGVPSFVVPS 81 W A R RR A + + GER + RV G + G LG Sbjct: 5 WGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLG-------- 56 Query: 82 SGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQ 141 R GA+ R P P + + +CG +L V WG G + Q Sbjct: 57 -----RRGAQ--RGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVF-AWGAG--SEGQ 106 Query: 142 LGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNN 201 LG + E P + D +++QVSCG HSL L+ VFS G N Sbjct: 107 LGIGEFK-------EISFTPKKIMTLND----IKIIQVSCGHYHSLALSKDSQVFSWGKN 155 Query: 202 SYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADG 260 S+GQ G + E S++ R++ +G + QVA G HS L+ G + G + G Sbjct: 156 SHGQLG---LGKEFPSQA-SPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAG 211 Query: 261 QTGLGHYNI---TSSPTKLGGDLAGVNVIQVATYGDCCLAV-SADGGLFGWGNSEYLQLA 316 Q L N+ ++ P +G L + V+ ++ GD AV + DG +F +G++ QL Sbjct: 212 QLALSGRNVPVQSNKPLSVGA-LKNLGVVYISC-GDAHTAVLTQDGKVFTFGDNRSGQL- 268 Query: 317 SVTDSTQVNVPRCLHFSGVGKVRQAACGG-TGCAVLNGEGHVFVWGYG 363 + + + P+ + G V Q CG A ++ G V +G+G Sbjct: 269 GYSPTPEKRGPQLVERID-GLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315 >gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] Length = 4861 Score = 102 bits (254), Expect = 7e-22 Identities = 81/273 (29%), Positives = 132/273 (48%), Gaps = 26/273 (9%) Query: 177 LQVSCGR-AHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQ 234 L SCG HS+ LT+ VFS G+ YG+ G + + R +++ G+ VVQ Sbjct: 4084 LVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQ-----RRPRQIEALQGEEVVQ 4138 Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294 ++CG HS +T G++++ G G G+ GLG+ + P ++ L G + QVA + Sbjct: 4139 MSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNH 4197 Query: 295 CLAVSADGGL-FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353 LAVSADG + + +G+ +Y +L + + + + G+G +++ ACG L Sbjct: 4198 TLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIG-IKKVACGTQFSVALTK 4256 Query: 354 EGHVFVWGYGIL-----GKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAA 408 +GHV+ +G L G+ N P+ IP L G+ + + G H A Sbjct: 4257 DGHVYTFGQDRLIGLPEGRARNHNR---PQQIP-VLAGVI-------IEDVAVGAEHTLA 4305 Query: 409 LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 441 L + G+++ WG N G LG+G P VT Sbjct: 4306 LASNGDVYAWGSNSEGQLGLGHTNHVREPTLVT 4338 Score = 94.7 bits (234), Expect = 2e-19 Identities = 85/307 (27%), Positives = 143/307 (46%), Gaps = 22/307 (7%) Query: 164 VSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVH 223 V +P P ++ QV CG+ + V+ V + G SYG+ G+ ++ + Sbjct: 4017 VMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQG--NSDDLHVLTVIS 4074 Query: 224 RMQDFDGQVVQVACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAG 282 +Q F + +CG D HS+ LT+ GEV+S G G G+ G G+ + P ++ L G Sbjct: 4075 ALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEA-LQG 4133 Query: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342 V+Q++ V++DG LF +GN +Y +L S + R G ++ Q A Sbjct: 4134 EEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGY-QIGQVA 4192 Query: 343 CGGTGCAVLNGEGHVFVWG-----YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVS 397 CG ++ +G + VW YG LG G + +S+ P+ I L G I + Sbjct: 4193 CGLNHTLAVSADGSM-VWAFGDGDYGKLGLGNSTAKSS-PQKI-DVLCG-------IGIK 4242 Query: 398 RIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV--DVACGVDH 455 ++ CG ALT G ++ +G++ L GR + P ++ + + DVA G +H Sbjct: 4243 KVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEH 4302 Query: 456 MVTLAKS 462 + LA + Sbjct: 4303 TLALASN 4309 Score = 79.7 bits (195), Expect = 5e-15 Identities = 75/244 (30%), Positives = 112/244 (45%), Gaps = 21/244 (8%) Query: 172 QETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ 231 Q V+Q+SCG HS V+T +F+ GN YG+ G N+ E RV ++ + Q Sbjct: 4132 QGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPE--RVTALEGY--Q 4187 Query: 232 VVQVACGQDHSLFLTDKGE-VYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290 + QVACG +H+L ++ G V++ G G G+ GLG+ SSP K+ L G+ + +VA Sbjct: 4188 IGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKI-DVLCGIGIKKVAC 4246 Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAV 350 +A++ DG ++ +G + L + N P+ + + A G Sbjct: 4247 GTQFSVALTKDGHVYTFGQDRLIGLPE-GRARNHNRPQQIPVLAGVIIEDVAVGAEHTLA 4305 Query: 351 LNGEGHVFVWG---YGILGKG-PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHF 406 L G V+ WG G LG G N V P + GL N V +I G H Sbjct: 4306 LASNGDVYAWGSNSEGQLGLGHTNHVRE------PTLVTGLQGKN----VRQISAGRCHS 4355 Query: 407 AALT 410 AA T Sbjct: 4356 AAWT 4359 Score = 78.2 bits (191), Expect = 1e-14 Identities = 72/250 (28%), Positives = 112/250 (44%), Gaps = 23/250 (9%) Query: 185 HSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ-VACGQDHSL 243 H+L T VFS G+ YG+ G + Y + + G+VV V+ G HS Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQ----GPLQGKVVVCVSAGYRHSA 524 Query: 244 FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGG 303 +T+ GE+Y+ G G G+ G G N + PT L D++ NV +V+ +A+S DG Sbjct: 525 AVTEDGELYTWGEGDFGRLGHGDSNSRNIPT-LVKDIS--NVGEVSCGSSHTIALSKDGR 581 Query: 304 L---FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360 FG G++ L D+ +V P+ + +R+ G L G V+ W Sbjct: 582 TVWSFGGGDNGKLGHG---DTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638 Query: 361 GYGI-LGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419 G G LG G + + P++I E ++ + G SH AL++ E++ WG Sbjct: 639 GCGACLGCGSSEATALRPKLI--------EELAATRIVDVSIGDSHCLALSHDNEVYAWG 690 Query: 420 KNIRGCLGIG 429 N G G G Sbjct: 691 NNSMGQCGQG 700 Score = 74.7 bits (182), Expect = 2e-13 Identities = 69/260 (26%), Positives = 113/260 (43%), Gaps = 23/260 (8%) Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE-----IYSESHRVHRMQDFDGQVV 233 + G+ + V++ V + G SYG+ G N+ + E HR + V Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKK-------V 460 Query: 234 QVACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292 + G D H+L T +GEV+S G G G+ G G+ + P + G L G V+ V+ Sbjct: 461 SSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGY 520 Query: 293 DCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLN 352 AV+ DG L+ WG ++ +L DS N+P + + V + +CG + L+ Sbjct: 521 RHSAAVTEDGELYTWGEGDFGRLGH-GDSNSRNIPTLV--KDISNVGEVSCGSSHTIALS 577 Query: 353 GEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412 +G VW +G G L + P + E + + ++ G ALT+ Sbjct: 578 KDGRT-VWSFG-GGDNGKLGHGDTNRVYKPKVI---EALQGMFIRKVCAGSQSSLALTST 632 Query: 413 GELFVWGKNIRGCLGIGRLE 432 G+++ WG CLG G E Sbjct: 633 GQVYAWG--CGACLGCGSSE 650 Score = 68.6 bits (166), Expect = 1e-11 Identities = 45/160 (28%), Positives = 77/160 (48%), Gaps = 15/160 (9%) Query: 174 TRVLQVSCGRAHSLVLT-DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHR---MQDFD 229 + V +VSCG +H++ L+ D V+S G G+ G + +++RV++ ++ Sbjct: 561 SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLG--------HGDTNRVYKPKVIEALQ 612 Query: 230 GQVVQVAC-GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288 G ++ C G SL LT G+VY+ WG G G T+ KL +LA ++ V Sbjct: 613 GMFIRKVCAGSQSSLALTSTGQVYA--WGCGACLGCGSSEATALRPKLIEELAATRIVDV 670 Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 328 + CLA+S D ++ WGN+ Q + + P+ Sbjct: 671 SIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPK 710 Score = 67.4 bits (163), Expect = 3e-11 Identities = 74/267 (27%), Positives = 108/267 (40%), Gaps = 38/267 (14%) Query: 210 VVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNI 269 V E+E+ + D Q++ A + L K +VY G G GQ N+ Sbjct: 3958 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNV 4017 Query: 270 TSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG----------GLFGWGNSEYLQLASVT 319 A QV +C + A+G G G GNS+ L + +V Sbjct: 4018 MVPAAAPSFSQAQ----QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 4073 Query: 320 DSTQVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESA 375 + Q V L S CG G ++ L G VF WG YG LG G N Sbjct: 4074 SALQGFVVTQLVTS---------CGSDGHSMALTESGEVFSWGDGDYGKLGHG-NSDRQR 4123 Query: 376 VPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQY 435 P I E +V ++ CG H A +T+ G+LF +G G LG+G ++ Sbjct: 4124 RPRQI--------EALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 4175 Query: 436 FPWRVT-MPGEPV-DVACGVDHMVTLA 460 P RVT + G + VACG++H + ++ Sbjct: 4176 LPERVTALEGYQIGQVACGLNHTLAVS 4202 Score = 66.6 bits (161), Expect = 4e-11 Identities = 63/218 (28%), Positives = 85/218 (38%), Gaps = 18/218 (8%) Query: 250 EVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGN 309 EVY G + Q G P KL + I+ Y C +S DG + G Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQP-KLAPSFSDAQTIEAGQY--CTFVISTDGSVRACGK 429 Query: 310 SEYLQLASVTDSTQVNVPRCLHFS---GVGKVRQAACGGTGCAVLNGEGHVFVWG---YG 363 Y +L + DS + + L F + KV + EG VF WG YG Sbjct: 430 GSYGRLG-LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYG 488 Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423 LG G N P++I L G V + G H AA+T GEL+ WG+ Sbjct: 489 KLGHG-NSSTQKYPKLIQGPLQGKV-------VVCVSAGYRHSAAVTEDGELYTWGEGDF 540 Query: 424 GCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAK 461 G LG G + P V +V+CG H + L+K Sbjct: 541 GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSK 578 Score = 63.5 bits (153), Expect = 4e-10 Identities = 59/195 (30%), Positives = 87/195 (44%), Gaps = 36/195 (18%) Query: 108 KISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLP 167 +I ACG TL S AD + VW G +LG S + Sbjct: 4187 QIGQVACGLNHTLAVS--ADGSMVWAFGDGDYGKLGLGNSTAKSS--------------- 4229 Query: 168 LDRPQETRVL------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESH- 220 PQ+ VL +V+CG S+ LT V++ G + R + E + +H Sbjct: 4230 ---PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQD------RLIGLPEGRARNHN 4280 Query: 221 RVHRMQDFDGQVVQ-VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279 R ++ G +++ VA G +H+L L G+VY+ G ++GQ GLGH N PT + G Sbjct: 4281 RPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG- 4339 Query: 280 LAGVNVIQVATYGDC 294 L G NV Q++ G C Sbjct: 4340 LQGKNVRQISA-GRC 4353 Score = 43.5 bits (101), Expect = 4e-04 Identities = 48/203 (23%), Positives = 83/203 (40%), Gaps = 21/203 (10%) Query: 99 VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158 +P ++ + +CG T+ SK D VW G + +LG D R Y+ Sbjct: 553 IPTLVKDISNVGEVSCGSSHTIALSK--DGRTVWSFGGGDNGKLG----HGDTNRVYKPK 606 Query: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218 + ++ Q + +V G SL LT V++ G + CG + Sbjct: 607 V--------IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSE------AT 652 Query: 219 SHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277 + R +++ ++V V+ G H L L+ EVY+ G + GQ G G+ + K Sbjct: 653 ALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKV 712 Query: 278 GDLAGVNVIQVATYGDCCLAVSA 300 L G+ + Q++ LA +A Sbjct: 713 SGLDGIAIQQISAGTSHSLAWTA 735 >gi|4557445 regulator of chromosome condensation and BTB domain containing protein 2 [Homo sapiens] Length = 551 Score = 100 bits (250), Expect = 2e-21 Identities = 80/259 (30%), Positives = 119/259 (45%), Gaps = 20/259 (7%) Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREG-VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQ 226 LD ++ +S G +VL EG VF+ G+N+Y Q G + + H Sbjct: 92 LDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVP----CHIST 147 Query: 227 DFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNV 285 + QV++VACG HSL LT GEV++ G+ GQ G G P ++ G L V Sbjct: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV 207 Query: 286 IQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGG 345 + +A CC+AV G ++ WG + QL Q R G+ +V++ ACG Sbjct: 208 VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGI-RVQRVACGY 266 Query: 346 TGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 402 VL EG V+ WG YG LG G N + P + E + I+++ C Sbjct: 267 AHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPV------TVEKDRIIEIA--ACH 317 Query: 403 LSH-FAALTNKGELFVWGK 420 +H AA T G +++WG+ Sbjct: 318 STHTSAAKTQGGHVYMWGQ 336 Score = 99.4 bits (246), Expect = 6e-21 Identities = 83/283 (29%), Positives = 135/283 (47%), Gaps = 29/283 (10%) Query: 172 QETRVLQVSC--GRAHSLVL--TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227 +E ++++ +C G A + VL T + +F +G N G G V++ I R+ Sbjct: 40 EELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI-----EPRRLDS 94 Query: 228 FDGQVVQVAC----GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283 +G+ ++AC H + T +GEV++ G A Q G G N P + +L+ Sbjct: 95 LNGK--KIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNK 152 Query: 284 NVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR----CLHFSGVGKVR 339 VI+VA L +++DG +F WG + Q+ S + Q +PR CL V + Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQP-IPRRVTGCLQNKVVVTI- 210 Query: 340 QAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRI 399 ACG C + G V+VWGY G G + ++ + P + L I+V R+ Sbjct: 211 --ACGQMCCMAVVDTGEVYVWGYN--GNGQLGLGNSGNQPTPCRVAALQG----IRVQRV 262 Query: 400 RCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 442 CG +H LT++G+++ WG N G LG G +Q +P VT+ Sbjct: 263 ACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV 305 Score = 39.3 bits (90), Expect = 0.008 Identities = 43/154 (27%), Positives = 66/154 (42%), Gaps = 39/154 (25%) Query: 61 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQ--KISSAACGYGF 118 V+VWG++ +G LG + +SG QP P R+ Q ++ ACGY Sbjct: 226 VYVWGYNGNGQLG-----LGNSGN------------QPTPCRVAALQGIRVQRVACGYAH 268 Query: 119 TLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQ 178 TL+ D +V+ G N QLG + + Y P+PV++ DR E Sbjct: 269 TLV---LTDEGQVYAWGANSYGQLG---TGNKSNQSY-----PTPVTVEKDRIIEI---- 313 Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQC-GRKVV 211 +C H+ + G M +GQC G+ V+ Sbjct: 314 AACHSTHTSAAKTQGGHVYM----WGQCRGQSVI 343 >gi|57242759 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1 [Homo sapiens] Length = 531 Score = 92.8 bits (229), Expect = 6e-19 Identities = 81/289 (28%), Positives = 133/289 (46%), Gaps = 29/289 (10%) Query: 171 PQETRVLQVSC----GRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQ 226 PQE ++ +C + +L +TD + VF G N G ++ + + +++ Sbjct: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPK-----KLE 69 Query: 227 DFDGQVVQ-VACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284 G+ ++ ++ G H L T+ G VY+ G Q G G N +P ++ +L Sbjct: 70 GLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQ 129 Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQV---NVPRCLHFSGVGKVRQA 341 V++VA +A++ADG +F WG + Q+ S + + Q V CLH + +V Sbjct: 130 VVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGI 186 Query: 342 ACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 398 ACG T + G V+ WGY G LG G N ++ P + L + V++ Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-----GNQLTPVRVAAL----HSVCVNQ 237 Query: 399 IRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV 447 I CG +H ALT++G L+ WG N G LG G + P + + E V Sbjct: 238 IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERV 286 Score = 57.4 bits (137), Expect = 3e-08 Identities = 45/159 (28%), Positives = 67/159 (42%), Gaps = 13/159 (8%) Query: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234 RV+ ++CG+ S+ + D V+ G N GQ G N++ RV + V Q Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPV--RVAALHSVC--VNQ 237 Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294 + CG H+L LTD+G +Y+ G GQ G G+ N SP + + V I Sbjct: 238 IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHT 297 Query: 295 CLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 333 A + G ++ WG V +P HFS Sbjct: 298 SAAKTQGGHVYMWGQCR---------GQSVILPHLTHFS 327 >gi|126032348 hect domain and RLD 2 [Homo sapiens] Length = 4834 Score = 90.1 bits (222), Expect = 4e-18 Identities = 88/289 (30%), Positives = 125/289 (43%), Gaps = 28/289 (9%) Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQCG---RKVVENEIYSESHRVHRMQDFDGQVVQV 235 V G H+ LT VFS G G+ G R + E+ + R++D + Sbjct: 3052 VHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRD-------I 3104 Query: 236 ACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVA--TYGD 293 ACG HS LT GE+Y+ G G G+ G G N T K+ L G VIQVA + Sbjct: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGD-NTTQLKPKMVKVLLGHRVIQVACGSRDA 3163 Query: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353 LA++ +G +F WG+ ++ +L S N+P+ + V Q CG L Sbjct: 3164 QTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTK 3222 Query: 354 EGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410 G V+ WG Y LG G S V P + GL ++ + G H A+T Sbjct: 3223 SGVVWTWGKGDYFRLGHG-----SDVHVRKPQVVEGLR----GKKIVHVAVGALHCLAVT 3273 Query: 411 NKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPVD-VACGVDHMV 457 + G+++ WG N G G G P V + G+ + VACG H V Sbjct: 3274 DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3322 Score = 88.2 bits (217), Expect = 1e-17 Identities = 82/290 (28%), Positives = 123/290 (42%), Gaps = 40/290 (13%) Query: 130 KVWGMGLNKDSQLG-FHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLV 188 KV+ G D +LG F R DK R E + + R+ ++CG +HS Sbjct: 3067 KVFSWGEGDDGKLGHFSRMNCDKPRLIEAL-------------KTKRIRDIACGSSHSAA 3113 Query: 189 LTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV---HRMQDFDGQVVQVACG--QDHSL 243 LT +++ G YG+ G ++ + +V HR V+QVACG +L Sbjct: 3114 LTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHR-------VIQVACGSRDAQTL 3166 Query: 244 FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGG 303 LTD+G V+S G G G+ G G + P + L G V Q+ LA++ G Sbjct: 3167 ALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNI-ERLNGQGVCQIECGAQFSLALTKSGV 3225 Query: 304 LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG-- 361 ++ WG +Y +L +D V P+ + K+ A G C + G V+ WG Sbjct: 3226 VWTWGKGDYFRLGHGSD-VHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDN 3284 Query: 362 -YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410 +G G G V PTL E +++R+ CG SH A T Sbjct: 3285 DHGQQGNGTTTVNR------KPTLVQGLEGQ---KITRVACGSSHSVAWT 3325 Score = 87.4 bits (215), Expect = 2e-17 Identities = 83/304 (27%), Positives = 124/304 (40%), Gaps = 48/304 (15%) Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNS--------YGQCGRKVVENEIYSESHRVHRMQD 227 V Q++C L+L+ V++ NS G R +V+ +S+ H Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLVQGLASRNIVKIAAHSDGH------- 505 Query: 228 FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP---TKLGGDLAGVN 284 H L L GEVYS G G G+ G G P + G AG + Sbjct: 506 -------------HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKH 552 Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344 V+ +A A++A+G L+ WG Y +L + + G+ KV ACG Sbjct: 553 VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACG 611 Query: 345 GTGCAVL--NGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRI 399 L G V+ WG YG LG+G + P++I E ++ V ++ Sbjct: 612 SGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLI--------EKLQDLDVVKV 662 Query: 400 RCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 457 RCG ALT G+++ WGK LG G E +P + + G+ V DVA G H + Sbjct: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCL 722 Query: 458 TLAK 461 L + Sbjct: 723 ALTE 726 Score = 86.3 bits (212), Expect = 5e-17 Identities = 83/283 (29%), Positives = 127/283 (44%), Gaps = 25/283 (8%) Query: 190 TDREGVFSMGNNSYGQCGR-KVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDK 248 T R VF G N Q G K + ++ S S + + VVQVA G +T + Sbjct: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-----VVQVAGGSKSLFAVTVE 3010 Query: 249 GEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY--GDCCLAVSADGGLFG 306 G+VY+CG +G+ GLG + T + L+ V +VA + G A++ DG +F Sbjct: 3011 GKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFS 3070 Query: 307 WGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YG 363 WG + +L + + PR + ++R ACG + A L G ++ WG YG Sbjct: 3071 WGEGDDGKLGHFS-RMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG 3129 Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGL--SHFAALTNKGELFVWGKN 421 LG G N + P+M+ L +V ++ CG + ALT++G +F WG Sbjct: 3130 RLGHGDNTTQ-LKPKMVKVLL--------GHRVIQVACGSRDAQTLALTDEGLVFSWGDG 3180 Query: 422 IRGCLGIGRLEDQYFPWRV-TMPGEPV-DVACGVDHMVTLAKS 462 G LG G E P + + G+ V + CG + L KS Sbjct: 3181 DFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKS 3223 Score = 80.5 bits (197), Expect = 3e-15 Identities = 69/250 (27%), Positives = 112/250 (44%), Gaps = 20/250 (8%) Query: 167 PLDRPQETR------VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESH 220 P DRP+ V+ V+ G AHS +T +++ G YG+ G E+++ + Sbjct: 4078 PCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQL--KPK 4135 Query: 221 RVHRMQDFDGQVVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGG 278 V +Q +VV +ACG +L LTD V+S G G G+ G G + P K+ Sbjct: 4136 LVEALQGH--RVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKI-D 4192 Query: 279 DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 338 L G+ V++V +A++ G ++ WG +Y +L +D V PR + KV Sbjct: 4193 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDD-HVRRPRQVQGLQGKKV 4251 Query: 339 RQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 398 A G C +G V+ WG G+ + +A+ P L + +V+R Sbjct: 4252 IAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR---PRLVAALQGK---KVNR 4305 Query: 399 IRCGLSHFAA 408 + CG +H A Sbjct: 4306 VACGSAHTLA 4315 Score = 75.5 bits (184), Expect = 1e-13 Identities = 56/204 (27%), Positives = 96/204 (47%), Gaps = 8/204 (3%) Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSES 219 EP +S + V+ ++CG +S +T +++ G +YG+ G E+E + Sbjct: 537 EPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE--AIP 594 Query: 220 HRVHRMQDFDGQVVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277 V ++ +V+ VACG +L +T+ G+V+S G G G+ G G + +P KL Sbjct: 595 MLVAGLKGL--KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTP-KLI 651 Query: 278 GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGK 337 L ++V++V +A++ DG ++ WG + +L T+ V P+ L K Sbjct: 652 EKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEE-HVRYPKLLEGLQGKK 710 Query: 338 VRQAACGGTGCAVLNGEGHVFVWG 361 V A G T C L + V WG Sbjct: 711 VIDVAAGSTHCLALTEDSEVHSWG 734 Score = 72.8 bits (177), Expect = 6e-13 Identities = 49/142 (34%), Positives = 73/142 (51%), Gaps = 7/142 (4%) Query: 175 RVLQVSCGR--AHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQV 232 +V+ V+CG A +L +T+ V+S G+ YG+ GR + + ++QD D V Sbjct: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--CKTPKLIEKLQDLD--V 659 Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292 V+V CG S+ LT G+VYS G G + + G G P L G L G VI VA Sbjct: 660 VKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG-LQGKKVIDVAAGS 718 Query: 293 DCCLAVSADGGLFGWGNSEYLQ 314 CLA++ D + WG+++ Q Sbjct: 719 THCLALTEDSEVHSWGSNDQCQ 740 Score = 72.8 bits (177), Expect = 6e-13 Identities = 85/290 (29%), Positives = 124/290 (42%), Gaps = 20/290 (6%) Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVAC 237 V+ G H L L+ V+S G G+ G N + RV ++ G +VV VA Sbjct: 4044 VNSGGKHCLALSSEGEVYSWGEAEDGKLGHG---NRSPCDRPRV--IESLRGIEVVDVAA 4098 Query: 238 GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDC-C 295 G HS +T G++Y+ G G G+ G P KL L G V+ +A GD Sbjct: 4099 GGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKP-KLVEALQGHRVVDIACGSGDAQT 4157 Query: 296 LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLH-FSGVGKVRQAACGGTGCAVLNGE 354 L ++ D ++ WG+ +Y +L S VP + +G+G V+ CG L Sbjct: 4158 LCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDSLTGLGVVK-VECGSQFSVALTKS 4215 Query: 355 GHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGE 414 G V+ WG G + + + V P + GL +V I G H T GE Sbjct: 4216 GAVYTWGKGDYHRLGHGSDDHVRR--PRQVQGLQGK----KVIAIATGSLHCVCCTEDGE 4269 Query: 415 LFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGVDHMVTLAKS 462 ++ WG N G LG G P V + G+ V+ VACG H + + S Sbjct: 4270 VYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4319 Score = 71.6 bits (174), Expect = 1e-12 Identities = 72/244 (29%), Positives = 107/244 (43%), Gaps = 20/244 (8%) Query: 185 HSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-----VVQVACGQ 239 H L L V+S G G+ G + + E +V + F G+ VV +ACG Sbjct: 506 HYLALAATGEVYSWGCGDGGRLGHG---DTVPLEEPKV--ISAFSGKQAGKHVVHIACGS 560 Query: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDC-CLA 297 +S +T +GE+Y+ G G G+ G G + P + G L G+ VI VA GD LA Sbjct: 561 TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAG-LKGLKVIDVACGSGDAQTLA 619 Query: 298 VSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHV 357 V+ +G ++ WG+ +Y +L S P+ + V + CG L +G V Sbjct: 620 VTENGQVWSWGDGDYGKLGR-GGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQV 678 Query: 358 FVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFV 417 + WG G + + E V P L GL +V + G +H ALT E+ Sbjct: 679 YSWGKGDNQRLGHGTEEHV--RYPKLLEGLQGK----KVIDVAAGSTHCLALTEDSEVHS 732 Query: 418 WGKN 421 WG N Sbjct: 733 WGSN 736 Score = 65.9 bits (159), Expect = 8e-11 Identities = 77/255 (30%), Positives = 110/255 (43%), Gaps = 21/255 (8%) Query: 214 EIYSESHRVHRMQDFDGQVVQVACGQ--DHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271 ++ ESH + + + D Q+VQ + D +L G +Y G GQ G Sbjct: 3916 DVLHESHDIFKREQ-DEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVK 3974 Query: 272 SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLH 331 PT LA + +Q+ AV+ADG L+ G +L + + V+ P L Sbjct: 3975 VPTPCEA-LATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLG-IGGTESVSTPTLLE 4032 Query: 332 FSGVGKVRQAAC--GGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFG 386 +++ A GG C L+ EG V+ WG G LG G N P +I +L G Sbjct: 4033 SIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHG-NRSPCDRPRVIE-SLRG 4090 Query: 387 LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPG- 444 I+V + G +H A +T G+L+ WGK G LG EDQ P V + G Sbjct: 4091 -------IEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH 4143 Query: 445 EPVDVACGVDHMVTL 459 VD+ACG TL Sbjct: 4144 RVVDIACGSGDAQTL 4158 Score = 55.1 bits (131), Expect = 1e-07 Identities = 54/185 (29%), Positives = 78/185 (42%), Gaps = 24/185 (12%) Query: 108 KISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLP 167 ++ ACG G T D T VW G +LG R D + V + Sbjct: 4144 RVVDIACGSGDAQTLCLTDDDT-VWSWGDGDYGKLG--RGGSDGCK----------VPMK 4190 Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESH--RVHRM 225 +D V++V CG S+ LT V++ G Y + G S+ H R ++ Sbjct: 4191 IDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG-------SDDHVRRPRQV 4243 Query: 226 QDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284 Q G+ V+ +A G H + T+ GEVY+ G +GQ G G N P +L L G Sbjct: 4244 QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRP-RLVAALQGKK 4302 Query: 285 VIQVA 289 V +VA Sbjct: 4303 VNRVA 4307 Score = 31.6 bits (70), Expect = 1.6 Identities = 29/100 (29%), Positives = 42/100 (42%), Gaps = 15/100 (15%) Query: 106 DQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165 D + CG F++ +K V WG G N+ +LG E+V P Sbjct: 656 DLDVVKVRCGSQFSIALTKDGQVYS-WGKGDNQ--RLGHGTE--------EHVRYPKL-- 702 Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQ 205 L+ Q +V+ V+ G H L LT+ V S G+N Q Sbjct: 703 --LEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740 >gi|110825982 hect domain and RLD 5 [Homo sapiens] Length = 1024 Score = 89.7 bits (221), Expect = 5e-18 Identities = 66/231 (28%), Positives = 113/231 (48%), Gaps = 10/231 (4%) Query: 209 KVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN 268 K E + YS H + +++Q+ CG HSL L+ GE+++ G GQ G+G Sbjct: 117 KPFEYDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKF 176 Query: 269 ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 328 +++ ++ LAGV + Q++ +A+S G ++ WG +E QL + + + P Sbjct: 177 PSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQL-GLGHTESKDDPS 235 Query: 329 CLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGL 387 + KV ACGG+ A+L +G +F +G G G+ G N ++ + + L G Sbjct: 236 LIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVG- 294 Query: 388 TEFNPEIQVSRIRCGLSH-FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437 +V++I CG H A +++ G++F +G G LG G DQ P Sbjct: 295 ------YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMP 339 Score = 78.6 bits (192), Expect = 1e-14 Identities = 63/195 (32%), Positives = 96/195 (49%), Gaps = 10/195 (5%) Query: 172 QETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG- 230 QE +++Q++CG HSL L+ +F+ G N +GQ G + + ++ G Sbjct: 136 QEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLG----VGRKFPSTTTPQIVEHLAGV 191 Query: 231 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290 + Q++ G+ HS+ L+ G +YS G GQ GLGH P+ + G L V VA Sbjct: 192 PLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG-LDNQKVEFVAC 250 Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVG-KVRQAACG-GTGC 348 G ++ DG LF +G ++ QL +STQ + CL VG +V Q ACG Sbjct: 251 GGSHSALLTQDGLLFTFGAGKHGQLGH--NSTQNELRPCLVAELVGYRVTQIACGRWHTL 308 Query: 349 AVLNGEGHVFVWGYG 363 A ++ G VF +G G Sbjct: 309 AYVSDLGKVFSFGSG 323 Score = 62.0 bits (149), Expect = 1e-09 Identities = 59/217 (27%), Positives = 98/217 (45%), Gaps = 46/217 (21%) Query: 56 ARADRVFVWGFSFSGALGV----PSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISS 111 ++ +F WG + G LGV PS P + + VP ++ Sbjct: 154 SKGGELFAWGQNLHGQLGVGRKFPSTTTP----------QIVEHLAGVP--------LAQ 195 Query: 112 AACGYGFTLLSSKTADVTKVWGMGLNKDSQLGF-HRSRKDKTRGYEYVLEPSPVSLPLDR 170 + G ++ S + + ++ G N+ QLG H KD +PS + + Sbjct: 196 ISAGEAHSMALSMSGN---IYSWGKNECGQLGLGHTESKD---------DPSLI----EG 239 Query: 171 PQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG 230 +V V+CG +HS +LT +F+ G +GQ G +NE+ R + + G Sbjct: 240 LDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNEL-----RPCLVAELVG 294 Query: 231 -QVVQVACGQDHSL-FLTDKGEVYSCGWGADGQTGLG 265 +V Q+ACG+ H+L +++D G+V+S G G DGQ G G Sbjct: 295 YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331 >gi|114796646 regulator of chromosome condensation 1 isoform b [Homo sapiens] Length = 438 Score = 87.4 bits (215), Expect = 2e-17 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%) Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159 P + + + + A G T+ SK+ +V+ G N + LG R G E V Sbjct: 77 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 128 Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217 P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E Sbjct: 129 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 176 Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277 + V D VV+VA G DH + LT G++Y+ G G GQ G + + G Sbjct: 177 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 236 Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322 G V A+S +G ++G+G S Y QL + + Sbjct: 237 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 296 Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378 F K GG V ++ EG + G YG LG G E ++P Sbjct: 297 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 356 Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438 +I VS + CG S A+T G +F WG LG G+ ED + P Sbjct: 357 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 405 Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461 V M G+ ++ V+ G H V L K Sbjct: 406 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 433 Score = 30.4 bits (67), Expect = 3.6 Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 1/63 (1%) Query: 401 CGLSHFAALTNKGELFVWGKNIRGCLGIG-RLEDQYFPWRVTMPGEPVDVACGVDHMVTL 459 C +SH + T G + G+ G LG+G + ++ P V++P + V G H V L Sbjct: 40 CQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCL 99 Query: 460 AKS 462 +KS Sbjct: 100 SKS 102 >gi|114796644 regulator of chromosome condensation 1 isoform a [Homo sapiens] Length = 452 Score = 87.4 bits (215), Expect = 2e-17 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%) Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159 P + + + + A G T+ SK+ +V+ G N + LG R G E V Sbjct: 91 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 142 Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217 P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E Sbjct: 143 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 190 Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277 + V D VV+VA G DH + LT G++Y+ G G GQ G + + G Sbjct: 191 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 250 Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322 G V A+S +G ++G+G S Y QL + + Sbjct: 251 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 310 Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378 F K GG V ++ EG + G YG LG G E ++P Sbjct: 311 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 370 Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438 +I VS + CG S A+T G +F WG LG G+ ED + P Sbjct: 371 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 419 Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461 V M G+ ++ V+ G H V L K Sbjct: 420 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 447 >gi|4502801 regulator of chromosome condensation 1 isoform c [Homo sapiens] Length = 421 Score = 87.4 bits (215), Expect = 2e-17 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%) Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159 P + + + + A G T+ SK+ +V+ G N + LG R G E V Sbjct: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111 Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217 P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159 Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277 + V D VV+VA G DH + LT G++Y+ G G GQ G + + G Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219 Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322 G V A+S +G ++G+G S Y QL + + Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279 Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378 F K GG V ++ EG + G YG LG G E ++P Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339 Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438 +I VS + CG S A+T G +F WG LG G+ ED + P Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388 Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461 V M G+ ++ V+ G H V L K Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416 >gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] Length = 421 Score = 87.4 bits (215), Expect = 2e-17 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%) Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159 P + + + + A G T+ SK+ +V+ G N + LG R G E V Sbjct: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111 Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217 P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159 Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277 + V D VV+VA G DH + LT G++Y+ G G GQ G + + G Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219 Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322 G V A+S +G ++G+G S Y QL + + Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279 Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378 F K GG V ++ EG + G YG LG G E ++P Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339 Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438 +I VS + CG S A+T G +F WG LG G+ ED + P Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388 Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461 V M G+ ++ V+ G H V L K Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416 >gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] Length = 421 Score = 87.4 bits (215), Expect = 2e-17 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%) Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159 P + + + + A G T+ SK+ +V+ G N + LG R G E V Sbjct: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111 Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217 P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159 Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277 + V D VV+VA G DH + LT G++Y+ G G GQ G + + G Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219 Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322 G V A+S +G ++G+G S Y QL + + Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279 Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378 F K GG V ++ EG + G YG LG G E ++P Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339 Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438 +I VS + CG S A+T G +F WG LG G+ ED + P Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388 Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461 V M G+ ++ V+ G H V L K Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416 >gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] Length = 421 Score = 87.4 bits (215), Expect = 2e-17 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%) Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159 P + + + + A G T+ SK+ +V+ G N + LG R G E V Sbjct: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111 Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217 P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159 Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277 + V D VV+VA G DH + LT G++Y+ G G GQ G + + G Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219 Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322 G V A+S +G ++G+G S Y QL + + Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279 Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378 F K GG V ++ EG + G YG LG G E ++P Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339 Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438 +I VS + CG S A+T G +F WG LG G+ ED + P Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388 Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461 V M G+ ++ V+ G H V L K Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416 >gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo sapiens] Length = 815 Score = 83.6 bits (205), Expect = 4e-16 Identities = 88/342 (25%), Positives = 146/342 (42%), Gaps = 72/342 (21%) Query: 177 LQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVA 236 + +SCG HS V+T ++ G+N++GQ G + S+ V ++ +V A Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAA 93 Query: 237 CGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCL 296 CG++H+L T+ G VY+ G +GQ GLG ++ + + + Q++ + Sbjct: 94 CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSA 153 Query: 297 AVSADGGLFGWGNSEYLQL-----ASVTDSTQVNVPRCLHFSGVG--------------- 336 A++ DG LF WG++ Q+ ++V QV + + + + G Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213 Query: 337 ------------------------------KVRQAACGGTGCAVLNGEGHVFVWG---YG 363 KV Q ACGG VL E V+ +G +G Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272 Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423 LG G L E++ P++I E + +S I CG +H A +T+ G ++ +G Sbjct: 273 QLGLGTFLFETSEPKVI--------ENIRDQTISYISCGENHTALITDIGLMYTFGDGRH 324 Query: 424 GCLGIGRLEDQYFPWRVTMPGEPVD-----VACGVDHMVTLA 460 G LG+G LE+ + T+ + VACG HMV A Sbjct: 325 GKLGLG-LENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365 Score = 80.5 bits (197), Expect = 3e-15 Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 22/240 (9%) Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292 V ++CG +HS +T ++Y G GQ GLG + S PT + +++A G Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKA--LKPEKVKLAACG 95 Query: 293 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 349 VS +GG G N L L + +V F+ K++Q + G A Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153 Query: 350 VLNGEGHVFVWGYGILGKG--PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFA 407 L +G +F+WG G+ N+ VP+ + T P VS I CG H A Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203 Query: 408 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 464 +T GEL+V+G+ G LG+ L + P V+ +P + + VACG +H V L ++ + Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263 Score = 63.2 bits (152), Expect = 5e-10 Identities = 59/243 (24%), Positives = 109/243 (44%), Gaps = 39/243 (16%) Query: 60 RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119 R+F+WG + G +G+ + VP ++ + + +S +CGY + Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVC-----------------VPQQVTIGKPVSWISCGYYHS 202 Query: 120 LLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQV 179 + ++ + G ++ +LG R + V E +P +V+QV Sbjct: 203 AFVTTDGEL---YVFGEPENGKLGLPNQLLGNHRTPQLVSE-----IP------EKVIQV 248 Query: 180 SCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239 +CG H++VLT+ V++ G +GQ G E SE + ++D + ++CG+ Sbjct: 249 ACGGEHTVVLTEN-AVYTFGLGQFGQLGLGTFLFET-SEPKVIENIRD--QTISYISCGE 304 Query: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS--PTKLGGDLAGVNVIQVATYGDCCLA 297 +H+ +TD G +Y+ G G G+ GLG N T+ PT L ++++ G C + Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLR--FIVKLVACGGCHMV 362 Query: 298 VSA 300 V A Sbjct: 363 VFA 365 >gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo sapiens] Length = 1152 Score = 83.6 bits (205), Expect = 4e-16 Identities = 88/342 (25%), Positives = 146/342 (42%), Gaps = 72/342 (21%) Query: 177 LQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVA 236 + +SCG HS V+T ++ G+N++GQ G + S+ V ++ +V A Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAA 93 Query: 237 CGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCL 296 CG++H+L T+ G VY+ G +GQ GLG ++ + + + Q++ + Sbjct: 94 CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSA 153 Query: 297 AVSADGGLFGWGNSEYLQL-----ASVTDSTQVNVPRCLHFSGVG--------------- 336 A++ DG LF WG++ Q+ ++V QV + + + + G Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213 Query: 337 ------------------------------KVRQAACGGTGCAVLNGEGHVFVWG---YG 363 KV Q ACGG VL E V+ +G +G Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272 Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423 LG G L E++ P++I E + +S I CG +H A +T+ G ++ +G Sbjct: 273 QLGLGTFLFETSEPKVI--------ENIRDQTISYISCGENHTALITDIGLMYTFGDGRH 324 Query: 424 GCLGIGRLEDQYFPWRVTMPGEPVD-----VACGVDHMVTLA 460 G LG+G LE+ + T+ + VACG HMV A Sbjct: 325 GKLGLG-LENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365 Score = 80.5 bits (197), Expect = 3e-15 Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 22/240 (9%) Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292 V ++CG +HS +T ++Y G GQ GLG + S PT + +++A G Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKA--LKPEKVKLAACG 95 Query: 293 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 349 VS +GG G N L L + +V F+ K++Q + G A Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153 Query: 350 VLNGEGHVFVWGYGILGKG--PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFA 407 L +G +F+WG G+ N+ VP+ + T P VS I CG H A Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203 Query: 408 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 464 +T GEL+V+G+ G LG+ L + P V+ +P + + VACG +H V L ++ + Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263 Score = 63.2 bits (152), Expect = 5e-10 Identities = 59/243 (24%), Positives = 109/243 (44%), Gaps = 39/243 (16%) Query: 60 RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119 R+F+WG + G +G+ + VP ++ + + +S +CGY + Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVC-----------------VPQQVTIGKPVSWISCGYYHS 202 Query: 120 LLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQV 179 + ++ + G ++ +LG R + V E +P +V+QV Sbjct: 203 AFVTTDGEL---YVFGEPENGKLGLPNQLLGNHRTPQLVSE-----IP------EKVIQV 248 Query: 180 SCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239 +CG H++VLT+ V++ G +GQ G E SE + ++D + ++CG+ Sbjct: 249 ACGGEHTVVLTEN-AVYTFGLGQFGQLGLGTFLFET-SEPKVIENIRD--QTISYISCGE 304 Query: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS--PTKLGGDLAGVNVIQVATYGDCCLA 297 +H+ +TD G +Y+ G G G+ GLG N T+ PT L ++++ G C + Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLR--FIVKLVACGGCHMV 362 Query: 298 VSA 300 V A Sbjct: 363 VFA 365 >gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] Length = 522 Score = 82.4 bits (202), Expect = 8e-16 Identities = 77/272 (28%), Positives = 124/272 (45%), Gaps = 43/272 (15%) Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ---- 231 V+ SC AHSL++T ++S G N GQ G + ++ RV + +G Sbjct: 153 VVSGSCA-AHSLLITTEGKLWSWGRNEKGQLG--------HGDTKRVEAPRLIEGLSHEV 203 Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVAT 290 +V ACG++H+L LT+ G V++ G GQ GLG+ + SP ++ + G + ++A Sbjct: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261 Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN-----------VPR----CLHFSGV 335 + + + G L+ +G EY QL +D + VPR + + Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321 Query: 336 GK--------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGL 387 G+ VR ACG VL+ + VF WG+G G+ L + + + P L L Sbjct: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKL 378 Query: 388 TEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419 +F P S+I G + A++ G LF WG Sbjct: 379 FDF-PGRGASQIYAGYTCSFAVSEVGGLFFWG 409 Score = 79.3 bits (194), Expect = 7e-15 Identities = 84/306 (27%), Positives = 126/306 (41%), Gaps = 52/306 (16%) Query: 109 ISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPL 168 I SAACG TL ++T V+ G NK QLG G + PSP + Sbjct: 204 IVSAACGRNHTLALTETG---SVFAFGENKMGQLGL---------GNQTDAVPSPAQIMY 251 Query: 169 DRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV------ 222 + T+ ++CG S+++ + ++S G YGQ G + + + + R+ Sbjct: 252 NGQPITK---MACGAEFSMIMDCKGNLYSFGCPEYGQLGHN-SDGKFIARAQRIEYDCEL 307 Query: 223 --HRMQDF-----DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY 267 R+ F DGQ++ VACG +H+L L + V+S G+G G+ G Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367 Query: 268 NITSSP--TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325 P KL D G Q+ C AVS GGLF WG A+ T Sbjct: 368 KDEMVPRLVKL-FDFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTM 419 Query: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIP 381 P+ + ++R ACG + V E + WG +G LG G + +S+ Sbjct: 420 YPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEV 478 Query: 382 PTLFGL 387 TL G+ Sbjct: 479 KTLDGI 484 Score = 65.5 bits (158), Expect = 1e-10 Identities = 57/224 (25%), Positives = 98/224 (43%), Gaps = 21/224 (9%) Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 291 VV +C HSL +T +G+++S G GQ G G +P + G L+ ++ A Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210 Query: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 351 + LA++ G +F +G ++ QL + V P + ++G + + ACG ++ Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269 Query: 352 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 393 + +G+++ +G YG LG + LV V I T G P Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329 Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437 + V + CG +H L ++ +F WG G LG +D+ P Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373 Score = 57.8 bits (138), Expect = 2e-08 Identities = 55/217 (25%), Positives = 99/217 (45%), Gaps = 27/217 (12%) Query: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRG----YEYVLEPS 162 Q I+ ACG F+++ ++ + G + QLG + K R Y+ L P Sbjct: 254 QPITKMACGAEFSMIMDCKGNL---YSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPR 310 Query: 163 PVSLPLDRPQETRVL--------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE 214 V++ +++ ++ ++L V+CG H+LVL ++ VFS G YG+ G ++E Sbjct: 311 RVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE 370 Query: 215 IYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 273 + R+ ++ DF G+ Q+ G S +++ G ++ WGA + ++ Sbjct: 371 MVP---RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFF--WGATNTS-----RESTMY 420 Query: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310 K DL G + +A G + V+AD WG S Sbjct: 421 PKAVQDLCGWRIRSLAC-GKSSIIVAADESTISWGPS 456 Score = 50.1 bits (118), Expect = 4e-06 Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%) Query: 278 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 334 G LAGV V V + G C L ++ +G L+ WG +E QL D+ +V PR + Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200 Query: 335 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 393 + AACG L G VF +G +G+ G AVP P + +N + Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254 Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 440 ++++ CG + KG L+ +G G LG I R + + P RV Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313 Query: 441 -----TMPGE--PV------DVACGVDHMVTL 459 T G+ PV DVACG +H + L Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345 >gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] Length = 522 Score = 82.4 bits (202), Expect = 8e-16 Identities = 77/272 (28%), Positives = 124/272 (45%), Gaps = 43/272 (15%) Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ---- 231 V+ SC AHSL++T ++S G N GQ G + ++ RV + +G Sbjct: 153 VVSGSCA-AHSLLITTEGKLWSWGRNEKGQLG--------HGDTKRVEAPRLIEGLSHEV 203 Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVAT 290 +V ACG++H+L LT+ G V++ G GQ GLG+ + SP ++ + G + ++A Sbjct: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261 Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN-----------VPR----CLHFSGV 335 + + + G L+ +G EY QL +D + VPR + + Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321 Query: 336 GK--------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGL 387 G+ VR ACG VL+ + VF WG+G G+ L + + + P L L Sbjct: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKL 378 Query: 388 TEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419 +F P S+I G + A++ G LF WG Sbjct: 379 FDF-PGRGASQIYAGYTCSFAVSEVGGLFFWG 409 Score = 79.3 bits (194), Expect = 7e-15 Identities = 84/306 (27%), Positives = 126/306 (41%), Gaps = 52/306 (16%) Query: 109 ISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPL 168 I SAACG TL ++T V+ G NK QLG G + PSP + Sbjct: 204 IVSAACGRNHTLALTETG---SVFAFGENKMGQLGL---------GNQTDAVPSPAQIMY 251 Query: 169 DRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV------ 222 + T+ ++CG S+++ + ++S G YGQ G + + + + R+ Sbjct: 252 NGQPITK---MACGAEFSMIMDCKGNLYSFGCPEYGQLGHN-SDGKFIARAQRIEYDCEL 307 Query: 223 --HRMQDF-----DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY 267 R+ F DGQ++ VACG +H+L L + V+S G+G G+ G Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367 Query: 268 NITSSP--TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325 P KL D G Q+ C AVS GGLF WG A+ T Sbjct: 368 KDEMVPRLVKL-FDFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTM 419 Query: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIP 381 P+ + ++R ACG + V E + WG +G LG G + +S+ Sbjct: 420 YPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEV 478 Query: 382 PTLFGL 387 TL G+ Sbjct: 479 KTLDGI 484 Score = 65.5 bits (158), Expect = 1e-10 Identities = 57/224 (25%), Positives = 98/224 (43%), Gaps = 21/224 (9%) Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 291 VV +C HSL +T +G+++S G GQ G G +P + G L+ ++ A Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210 Query: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 351 + LA++ G +F +G ++ QL + V P + ++G + + ACG ++ Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269 Query: 352 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 393 + +G+++ +G YG LG + LV V I T G P Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329 Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437 + V + CG +H L ++ +F WG G LG +D+ P Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373 Score = 57.8 bits (138), Expect = 2e-08 Identities = 55/217 (25%), Positives = 99/217 (45%), Gaps = 27/217 (12%) Query: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRG----YEYVLEPS 162 Q I+ ACG F+++ ++ + G + QLG + K R Y+ L P Sbjct: 254 QPITKMACGAEFSMIMDCKGNL---YSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPR 310 Query: 163 PVSLPLDRPQETRVL--------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE 214 V++ +++ ++ ++L V+CG H+LVL ++ VFS G YG+ G ++E Sbjct: 311 RVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE 370 Query: 215 IYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 273 + R+ ++ DF G+ Q+ G S +++ G ++ WGA + ++ Sbjct: 371 MVP---RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFF--WGATNTS-----RESTMY 420 Query: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310 K DL G + +A G + V+AD WG S Sbjct: 421 PKAVQDLCGWRIRSLAC-GKSSIIVAADESTISWGPS 456 Score = 50.1 bits (118), Expect = 4e-06 Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%) Query: 278 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 334 G LAGV V V + G C L ++ +G L+ WG +E QL D+ +V PR + Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200 Query: 335 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 393 + AACG L G VF +G +G+ G AVP P + +N + Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254 Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 440 ++++ CG + KG L+ +G G LG I R + + P RV Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313 Query: 441 -----TMPGE--PV------DVACGVDHMVTL 459 T G+ PV DVACG +H + L Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345 >gi|6912330 deafness locus associated putative guanine nucleotide exchange factor [Homo sapiens] Length = 458 Score = 80.5 bits (197), Expect = 3e-15 Identities = 99/362 (27%), Positives = 145/362 (40%), Gaps = 63/362 (17%) Query: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190 ++ G N QLG E VL P ++ D + V +++ G HS V+T Sbjct: 17 LFAWGANSYGQLGLGHK--------EDVLLPQQLN---DFCKPRSVRRITGGGGHSAVVT 65 Query: 191 DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGE 250 D +F G N GQ G E+ Y + F + QVACG D ++ LT+ G+ Sbjct: 66 DGGDLFVCGLNKDGQLGLGHTEDIPYFTPCK----SLFGCPIQQVACGWDFTIMLTENGQ 121 Query: 251 VYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310 V SCG + GQ G+ H +L V+ +A +A +A G +F WG Sbjct: 122 VLSCGSNSFGQLGVPH-GPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG 180 Query: 311 EYLQLASVTDSTQVNVPRCLHFSGVGKVR-------QAAC---GGTGCAVLNGEGHVFVW 360 LAS L F+ R +A C G A L G V+VW Sbjct: 181 ----LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVW 236 Query: 361 GYGILGKGPNLVESA---VPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFV 417 G G+ N E+A VP+ I F +V+ I G +H A T G++F Sbjct: 237 GSNKHGQLAN--EAAFLPVPQKIEAHCF------QNEKVTAIWSGWTHLVAQTETGKMFT 288 Query: 418 WGKNIRGCLGIGRLEDQYFPWRV--------------TMPGEP------VDVACGVDHMV 457 WG+ G L GR + Y W++ +MP P +V+CG +H + Sbjct: 289 WGRADYGQL--GRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNL 346 Query: 458 TL 459 + Sbjct: 347 AI 348 Score = 74.7 bits (182), Expect = 2e-13 Identities = 97/374 (25%), Positives = 149/374 (39%), Gaps = 67/374 (17%) Query: 122 SSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSC 181 S+ D ++ GLNKD QLG + E P P + QV+C Sbjct: 61 SAVVTDGGDLFVCGLNKDGQLGLGHT------------EDIPYFTPCKSLFGCPIQQVAC 108 Query: 182 GRAHSLVLTDREGVFSMGNNSYGQCG------RKVVENEIYSESHRVHRMQDFDGQVVQV 235 G +++LT+ V S G+NS+GQ G R VV I E H+ +VV + Sbjct: 109 GWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAI--ELHK--------EKVVCI 158 Query: 236 ACGQDHSLFLTDKGEVYSCGWG--------ADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 287 A G H++ T G V+ G G GQT L + P+++ G L + Sbjct: 159 AAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQT-LPLFFTAKEPSRVTG-LENSKAMC 216 Query: 288 VATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--HFSGVGKVRQAACGG 345 V D +++ G ++ WG++++ QLA+ ++ + VP+ + H KV G Sbjct: 217 VLAGSDHSASLTDAGEVYVWGSNKHGQLAN--EAAFLPVPQKIEAHCFQNEKVTAIWSGW 274 Query: 346 TGCAVLNGEGHVFVWG---YGILGKGPNLVE-------------SAVPEMIPPTLFGLTE 389 T G +F WG YG LG+ E S P +P + LT Sbjct: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLT- 333 Query: 390 FNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--TMPGEPV 447 + + CG H A+ G + WG N G G G + + P V + + Sbjct: 334 -----GATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGL 387 Query: 448 DVACGVDHMVTLAK 461 V CG H + L + Sbjct: 388 LVGCGAGHSLALCQ 401 >gi|222136641 NIMA-related kinase 9 [Homo sapiens] Length = 979 Score = 71.2 bits (173), Expect = 2e-12 Identities = 60/271 (22%), Positives = 112/271 (41%), Gaps = 47/271 (17%) Query: 60 RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119 +++ +G + G +GV P ++P+ L + +CG Sbjct: 446 QLYAFGSDYYGCMGVDKVAGPEV-------------LEPMQLNFFLSNPVEQVSCGDNHV 492 Query: 120 LLSSKTADVTKVWGMG----LNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETR 175 ++ ++ +V WG G L DS+ ++ +K +D P+ Sbjct: 493 VVLTRNKEVYS-WGCGEYGRLGLDSEEDYYTPQK------------------VDVPKALI 533 Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYG-----QCGRKVVENEIYSE-----SHRVHRM 225 ++ V CG + +LT V + G N + QC ++ +E Y E S + + Sbjct: 534 IVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQ 593 Query: 226 QDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNV 285 F ++ +A G+ H+ + ++G + + G GQ G+G+Y LGG L G V Sbjct: 594 LSFY-KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQV 652 Query: 286 IQVATYGDCCLAVSADGGLFGWGNSEYLQLA 316 I+V+ + +A + D +F WGN +LA Sbjct: 653 IRVSCGDEFTIAATDDNHIFAWGNGGNGRLA 683 Score = 67.0 bits (162), Expect = 3e-11 Identities = 70/276 (25%), Positives = 114/276 (41%), Gaps = 26/276 (9%) Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227 +++ Q + QVSCG ++ +TD +++ G++ YG G V E +++ Sbjct: 420 VEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF-- 477 Query: 228 FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 287 V QV+CG +H + LT EVYS G G G+ GL +P K+ A + ++ Sbjct: 478 LSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI-IVA 536 Query: 288 VATYGDCCLAVSADGGLFGWGNSEYLQL-------ASVTDSTQVNVPRCLHFS-----GV 335 V D ++ G + G +E+ +L + VP F+ Sbjct: 537 VQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSF 596 Query: 336 GKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNP 392 K+R A G T A ++ G + +G G LG G N + ++ L G Sbjct: 597 YKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG-NYKKRLGINLLGGPLGGK----- 650 Query: 393 EIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGI 428 QV R+ CG A T+ +F WG G L + Sbjct: 651 --QVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684 Score = 65.9 bits (159), Expect = 8e-11 Identities = 58/202 (28%), Positives = 87/202 (43%), Gaps = 18/202 (8%) Query: 271 SSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSE-----YLQLASVTDSTQVN 325 S+P KL +G + QV V+ + L+ W N + + QL D Sbjct: 357 STPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYR 415 Query: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPP 382 P+ + +RQ +CG + EG ++ +G YG +G + + A PE++ P Sbjct: 416 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMG----VDKVAGPEVLEP 471 Query: 383 TLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 442 NP QVS CG +H LT E++ WG G LG+ ED Y P +V + Sbjct: 472 MQLNFFLSNPVEQVS---CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDV 528 Query: 443 PGEPVDVA--CGVDHMVTLAKS 462 P + VA CG D L +S Sbjct: 529 PKALIIVAVQCGCDGTFLLTQS 550 Score = 62.4 bits (150), Expect = 8e-10 Identities = 74/274 (27%), Positives = 121/274 (44%), Gaps = 36/274 (13%) Query: 178 QVSCGRAHSLVLTDREGVFSM-----GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQV 232 QV G H V+T + +++ G +GQ G + Y + V ++Q G+ Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHG--DKASYRQPKHVEKLQ---GKA 427 Query: 233 V-QVACGQDHSLFLTDKGEVYSCG---WGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288 + QV+CG D ++ +TD+G++Y+ G +G G + + P +L L+ N ++ Sbjct: 428 IRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVL-EPMQLNFFLS--NPVEQ 484 Query: 289 ATYGDCCLAV-SADGGLFGWGNSEY--LQLASVTD---STQVNVPRCLHFSGVGKVRQAA 342 + GD + V + + ++ WG EY L L S D +V+VP+ L V Sbjct: 485 VSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAV------Q 538 Query: 343 CGGTGCAVLNGEGHVFVWGYGILGK-GPN------LVESAVPEMIPPTLFGLTEFNPEIQ 395 CG G +L G V G K G N + A E+ T F L + + Sbjct: 539 CGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYK 598 Query: 396 VSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIG 429 + I G +H AA+ +G L +G N G LG+G Sbjct: 599 IRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG 632 Score = 46.2 bits (108), Expect = 6e-05 Identities = 49/214 (22%), Positives = 89/214 (41%), Gaps = 32/214 (14%) Query: 57 RADRVFVWGFSFSGALGVPS---FVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAA 113 R V+ WG G LG+ S + P P+A I + Sbjct: 497 RNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI------------------IVAVQ 538 Query: 114 CGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQE 173 CG T L +++ KV GLN+ ++LG ++ Y P S L + Sbjct: 539 CGCDGTFLLTQSG---KVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLS 595 Query: 174 T-RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-- 230 ++ ++ G+ H+ + +R + + G N GQ G V N Y + ++ + G Sbjct: 596 FYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG---VGN--YKKRLGINLLGGPLGGK 650 Query: 231 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGL 264 QV++V+CG + ++ TD +++ G G +G+ + Sbjct: 651 QVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684 >gi|30039692 NIMA-related kinase 8 [Homo sapiens] Length = 692 Score = 63.5 bits (153), Expect = 4e-10 Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 26/209 (12%) Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD-GQVVQ 234 ++QV+CG +H L L+ +F+ G G+ G ESH + GQ Q Sbjct: 445 MVQVACGASHVLALSTERELFAWGRGDSGRLGLGT------RESHSCPQQVPMPPGQEAQ 498 Query: 235 -VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP------------TKLGG--- 278 V CG D S+ LT G+ +CG + GL H ++ P T LG Sbjct: 499 RVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPL 558 Query: 279 DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 338 D + I + T AV+A G + +G++++ QL + T + G+ K+ Sbjct: 559 DQEPLLSIDLGTAHSA--AVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGI-KM 615 Query: 339 RQAACGGTGCAVLNGEGHVFVWGYGILGK 367 ACG + E V+ WG G G+ Sbjct: 616 AMVACGDAFTVAIGAESEVYSWGKGARGR 644 Score = 60.5 bits (145), Expect = 3e-09 Identities = 76/312 (24%), Positives = 126/312 (40%), Gaps = 35/312 (11%) Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSES 219 +P +S L+ + V+CG + LTDR + + G+ S G G + + S+ Sbjct: 377 QPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTD--ISQP 434 Query: 220 HRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279 V + ++ +VQVACG H L L+ + E+++ G G G+ GLG S P ++ Sbjct: 435 TIVEALLGYE--MVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP 492 Query: 280 LAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA------SVTDSTQVNVPRCLHFS 333 G +V D + ++ G G++ + +L V L F+ Sbjct: 493 -PGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551 Query: 334 GVGK-------VRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPT 383 +G + G A + G + +G +G LG A P Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-----PCK 606 Query: 384 LFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--- 440 + GL I+++ + CG + A+ + E++ WGK RG LG R ED P V Sbjct: 607 VQGL----EGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLG-RRDEDAGLPRPVQLD 661 Query: 441 -TMPGEPVDVAC 451 T P V+C Sbjct: 662 ETHPYTVTSVSC 673 Score = 60.1 bits (144), Expect = 4e-09 Identities = 56/198 (28%), Positives = 80/198 (40%), Gaps = 22/198 (11%) Query: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW-------GNSEYLQLASVTDSTQVNV 326 T L + V+QVA V+ G L W G L A Q + Sbjct: 323 TPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQF-I 381 Query: 327 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG---ILGKGPNLVESAVPEMIPPT 383 R L ++ ACG A L G + +G G LG G +L + + P ++ Sbjct: 382 SRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHG-SLTDISQPTIVEAL 440 Query: 384 LFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMP 443 L ++ ++ CG SH AL+ + ELF WG+ G LG+G E P +V MP Sbjct: 441 L--------GYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP 492 Query: 444 --GEPVDVACGVDHMVTL 459 E V CG+D + L Sbjct: 493 PGQEAQRVVCGIDSSMIL 510 Score = 51.6 bits (122), Expect = 1e-06 Identities = 63/222 (28%), Positives = 94/222 (42%), Gaps = 29/222 (13%) Query: 224 RMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGW-----GADGQTGLGHYNITSSPTKLGG 278 R+ + +VVQVA G+ +T G + W GA G + L P + Sbjct: 326 RLPMLNTEVVQVAAGRTQKAGVTRSGRLIL--WEAPPLGAGGGSLLPGAVEQPQPQFISR 383 Query: 279 DL---AGVNVIQVATYGDCCLAVSADGGL---FGWGNSEYLQLASVTDSTQVNVPRCLHF 332 L +GV + VA GD A D G+ FG G++ L S+TD +Q + L Sbjct: 384 FLEGQSGVTIKHVAC-GDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEAL-- 440 Query: 333 SGVG-KVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVES-AVPEMIPPTLFGLTE 389 +G ++ Q ACG + L+ E +F WG G G+ G ES + P+ +P Sbjct: 441 --LGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVP-------- 490 Query: 390 FNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRL 431 P + R+ CG+ LT G+ G N LG+ L Sbjct: 491 MPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHL 532 Score = 50.8 bits (120), Expect = 3e-06 Identities = 52/209 (24%), Positives = 88/209 (42%), Gaps = 32/209 (15%) Query: 61 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120 +F WG SG LG+ G R +++ P Q+ CG ++ Sbjct: 464 LFAWGRGDSGRLGL----------GTRESHSCPQQVPMPP-----GQEAQRVVCGIDSSM 508 Query: 121 LSSKTADVTKVWGMGLNKDSQLGF-HRSRKDKTRGYEYVLEPSPVSL----PLDRPQETR 175 + + G N+ ++LG H S ++ ++ V E +L PLD+ Sbjct: 509 ILTVPGQAL---ACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP--- 562 Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQ 234 +L + G AHS +T ++ G+N +GQ G S ++Q +G ++ Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG-----SRAPCKVQGLEGIKMAM 617 Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTG 263 VACG ++ + + EVYS G GA G+ G Sbjct: 618 VACGDAFTVAIGAESEVYSWGKGARGRLG 646 >gi|63054860 RCC1 domain containing 1 [Homo sapiens] Length = 376 Score = 61.6 bits (148), Expect = 1e-09 Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 24/212 (11%) Query: 157 YVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIY 216 YV +P PL E R Q+ G H+L+L VFS G +GQ G +E E+ Sbjct: 143 YVSPRAPFYRPL--APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199 Query: 217 SESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL 276 E + +Q + +VA G HS+ +++ G++Y GW GQ L N+ Sbjct: 200 -EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED---- 252 Query: 277 GGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGV 335 G V + AT + V GG + ++ + P L Sbjct: 253 -----GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP--------FPALLDLPMG 299 Query: 336 GKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367 +A+CG AV+ G ++ WG+G G+ Sbjct: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331 Score = 57.0 bits (136), Expect = 4e-08 Identities = 59/194 (30%), Positives = 79/194 (40%), Gaps = 22/194 (11%) Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 293 Q+ G +H+L L G+V+S G G GQ G G P L L G+ + +VA G Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220 Query: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353 + VS G ++ WG +E QLA T R L G R+A LN Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265 Query: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413 +G G P + P P L L + ++ S CG H A +T G Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319 Query: 414 ELFVWGKNIRGCLG 427 EL+ WG G LG Sbjct: 320 ELYTWGWGKYGQLG 333 Score = 38.9 bits (89), Expect = 0.010 Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%) Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271 V+ +CG H+ +T GE+Y+ GWG GQ LGH + TS Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339 Score = 38.5 bits (88), Expect = 0.013 Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 3/89 (3%) Query: 163 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 222 P LD P + ++ SCG H+ V+T +++ G YGQ G + + RV Sbjct: 289 PFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE--DTTSLDRPRRV 346 Query: 223 HRMQDFDGQVVQVACGQDHS-LFLTDKGE 250 D QV V CG ++ ++ +KG+ Sbjct: 347 EYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375 Score = 34.3 bits (77), Expect = 0.25 Identities = 16/46 (34%), Positives = 23/46 (50%) Query: 392 PEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437 PE++ ++ G H L G++F WG G LG G LE + P Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201 >gi|63054858 RCC1 domain containing 1 [Homo sapiens] Length = 376 Score = 61.6 bits (148), Expect = 1e-09 Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 24/212 (11%) Query: 157 YVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIY 216 YV +P PL E R Q+ G H+L+L VFS G +GQ G +E E+ Sbjct: 143 YVSPRAPFYRPL--APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199 Query: 217 SESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL 276 E + +Q + +VA G HS+ +++ G++Y GW GQ L N+ Sbjct: 200 -EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED---- 252 Query: 277 GGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGV 335 G V + AT + V GG + ++ + P L Sbjct: 253 -----GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP--------FPALLDLPMG 299 Query: 336 GKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367 +A+CG AV+ G ++ WG+G G+ Sbjct: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331 Score = 57.0 bits (136), Expect = 4e-08 Identities = 59/194 (30%), Positives = 79/194 (40%), Gaps = 22/194 (11%) Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 293 Q+ G +H+L L G+V+S G G GQ G G P L L G+ + +VA G Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220 Query: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353 + VS G ++ WG +E QLA T R L G R+A LN Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265 Query: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413 +G G P + P P L L + ++ S CG H A +T G Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319 Query: 414 ELFVWGKNIRGCLG 427 EL+ WG G LG Sbjct: 320 ELYTWGWGKYGQLG 333 Score = 38.9 bits (89), Expect = 0.010 Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%) Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271 V+ +CG H+ +T GE+Y+ GWG GQ LGH + TS Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339 Score = 38.5 bits (88), Expect = 0.013 Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 3/89 (3%) Query: 163 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 222 P LD P + ++ SCG H+ V+T +++ G YGQ G + + RV Sbjct: 289 PFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE--DTTSLDRPRRV 346 Query: 223 HRMQDFDGQVVQVACGQDHS-LFLTDKGE 250 D QV V CG ++ ++ +KG+ Sbjct: 347 EYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375 Score = 34.3 bits (77), Expect = 0.25 Identities = 16/46 (34%), Positives = 23/46 (50%) Query: 392 PEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437 PE++ ++ G H L G++F WG G LG G LE + P Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201 >gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens] Length = 1353 Score = 58.5 bits (140), Expect = 1e-08 Identities = 47/171 (27%), Positives = 76/171 (44%), Gaps = 10/171 (5%) Query: 190 TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKG 249 TD V++ G+N+ G ++ + E + + QV + HS+FL+ KG Sbjct: 139 TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGI--YIKQVVLCKFHSVFLSQKG 196 Query: 250 EVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGN 309 +VY+CG G G+ G G P + G L G N QVA D + ++ DG ++ +G Sbjct: 197 QVYTCGHGPGGRLGHGDEQTCLVPRLVEG-LNGHNCSQVAAAKDHTVVLTEDGCVYTFGL 255 Query: 310 SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360 + + QL + + NVPR + + G T V G H +W Sbjct: 256 NIFHQLGIIPPPSSCNVPRQIQ-------AKYLKGRTIIGVAAGRFHTVLW 299 >gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo sapiens] Length = 596 Score = 53.9 bits (128), Expect = 3e-07 Identities = 53/194 (27%), Positives = 80/194 (41%), Gaps = 30/194 (15%) Query: 195 VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYS 253 VFS G+ +G+ GR E + ++ +GQ V Q+ CG L LT G V++ Sbjct: 25 VFSWGDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 79 Query: 254 CGWGADGQTGLGHYNITS--SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSE 311 WG LGH + P + G L G ++ VA CLAV G ++ WG+++ Sbjct: 80 --WGKGDYFRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 136 Query: 312 YLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNL 371 + Q + T +T P + K+ ACG + H W Sbjct: 137 HGQQGNGT-TTVNRKPTLVQGLEGQKIMCVACGSS---------HSVAW---------TT 177 Query: 372 VESAVPEMIPPTLF 385 V+ A P + P LF Sbjct: 178 VDVATPSVHEPVLF 191 Score = 50.4 bits (119), Expect = 3e-06 Identities = 39/126 (30%), Positives = 58/126 (46%), Gaps = 13/126 (10%) Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227 ++R V Q+ CG L LT V++ G Y + G + S+ H V + Q Sbjct: 50 IERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHR-------SDVH-VRKPQV 101 Query: 228 FDG----QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283 +G ++V VA G H L + D G+VY+ G GQ G G + PT + G L G Sbjct: 102 VEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG-LEGQ 160 Query: 284 NVIQVA 289 ++ VA Sbjct: 161 KIMCVA 166 Score = 43.5 bits (101), Expect = 4e-04 Identities = 41/156 (26%), Positives = 64/156 (41%), Gaps = 9/156 (5%) Query: 304 LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG 363 +F WG+ ++ +L S N+P+ + V Q CG L G V+ WG G Sbjct: 25 VFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83 Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423 + + S V P + GL ++ + G H A+ + G+++ WG N Sbjct: 84 DYFRLGH--RSDVHVRKPQVVEGLRGK----KIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137 Query: 424 GCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 457 G G G P V + G+ + VACG H V Sbjct: 138 GQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSV 173 Score = 29.6 bits (65), Expect = 6.1 Identities = 24/68 (35%), Positives = 28/68 (41%), Gaps = 8/68 (11%) Query: 354 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412 E VF WG G GK G E IP + L V +I CG ALT Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 74 Query: 413 GELFVWGK 420 G ++ WGK Sbjct: 75 GVVWTWGK 82 >gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo sapiens] Length = 1102 Score = 52.8 bits (125), Expect = 7e-07 Identities = 50/193 (25%), Positives = 80/193 (41%), Gaps = 28/193 (14%) Query: 195 VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYS 253 VFS G+ +G+ GR E + ++ +GQ V Q+ CG L LT G V++ Sbjct: 727 VFSWGDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 781 Query: 254 CGWGADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEY 312 WG LGH + + ++ L G ++ VA CLAV G ++ WG++++ Sbjct: 782 --WGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 839 Query: 313 LQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLV 372 Q + T +T P + K+ ACG + H W + Sbjct: 840 GQQGNGT-TTVNRKPMLVQGLEGQKIMCVACGSS---------HSVAW---------TTM 880 Query: 373 ESAVPEMIPPTLF 385 + A P + P LF Sbjct: 881 DVATPSVHEPVLF 893 Score = 49.7 bits (117), Expect = 6e-06 Identities = 38/126 (30%), Positives = 58/126 (46%), Gaps = 13/126 (10%) Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227 ++R V Q+ CG L LT V++ G Y + G + S+ H V ++Q Sbjct: 752 IERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHR-------SDVH-VRKLQV 803 Query: 228 FDG----QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283 +G ++V VA G H L + D G+VY+ G GQ G G + P + G L G Sbjct: 804 VEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQG-LEGQ 862 Query: 284 NVIQVA 289 ++ VA Sbjct: 863 KIMCVA 868 Score = 43.1 bits (100), Expect = 5e-04 Identities = 41/159 (25%), Positives = 66/159 (41%), Gaps = 10/159 (6%) Query: 302 GGL-FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360 GGL F WG+ ++ +L S N+P+ + V Q CG L G V+ W Sbjct: 724 GGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 782 Query: 361 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK 420 G G + + + V ++ + E ++ + G H A+ + G+++ WG Sbjct: 783 GKGDYFRLGHRSDVHVRKL------QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGD 836 Query: 421 NIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 457 N G G G P V + G+ + VACG H V Sbjct: 837 NDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSV 875 Score = 30.4 bits (67), Expect = 3.6 Identities = 50/188 (26%), Positives = 64/188 (34%), Gaps = 30/188 (15%) Query: 247 DKGEVYSCGWGADGQTGLGHYN--------ITSSPTKLGGDLAGV--NVIQVATYGDCC- 295 D+GE + G ADG +YN +P G A + +GD C Sbjct: 613 DEGE--AAGAAADGVAAYSNYNNGHRKFLATAQNPADEPGPGAPAPQELGAAGKHGDLCE 670 Query: 296 --LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353 L SA G W + + V + GKV T C + Sbjct: 671 VSLTSSAQGEAT-WPHPVLFHFGEIIQDKSVGN---WEYISTGKVSDNYALLTKCEM--- 723 Query: 354 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412 G VF WG G GK G E IP + L V +I CG ALT Sbjct: 724 GGLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 776 Query: 413 GELFVWGK 420 G ++ WGK Sbjct: 777 GVVWTWGK 784 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.320 0.138 0.432 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 18,802,236 Number of Sequences: 37866 Number of extensions: 897931 Number of successful extensions: 3050 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 38 Number of HSP's successfully gapped in prelim test: 12 Number of HSP's that attempted gapping in prelim test: 2450 Number of HSP's gapped (non-prelim): 189 length of query: 464 length of database: 18,247,518 effective HSP length: 106 effective length of query: 358 effective length of database: 14,233,722 effective search space: 5095672476 effective search space used: 5095672476 T: 11 A: 40 X1: 16 ( 7.4 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.8 bits) S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.