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Search of human proteins with 13540582
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
(464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 954 0.0
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 561 e-160
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 561 e-160
gi|7657152 hect domain and RLD 3 [Homo sapiens] 122 5e-28
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 120 2e-27
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 120 2e-27
gi|61563742 hect domain and RLD 6 [Homo sapiens] 105 9e-23
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 102 7e-22
gi|4557445 regulator of chromosome condensation and BTB domain c... 100 2e-21
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 93 6e-19
gi|126032348 hect domain and RLD 2 [Homo sapiens] 90 4e-18
gi|110825982 hect domain and RLD 5 [Homo sapiens] 90 5e-18
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 87 2e-17
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 87 2e-17
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 87 2e-17
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 87 2e-17
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 87 2e-17
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 87 2e-17
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 84 4e-16
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 84 4e-16
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 82 8e-16
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 82 8e-16
gi|6912330 deafness locus associated putative guanine nucleotide... 80 3e-15
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 71 2e-12
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 64 4e-10
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 62 1e-09
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 62 1e-09
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens] 59 1e-08
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 54 3e-07
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 53 7e-07
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 954 bits (2466), Expect = 0.0
Identities = 464/464 (100%), Positives = 464/464 (100%)
Query: 1 MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADR 60
MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADR
Sbjct: 1 MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADR 60
Query: 61 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120
VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL
Sbjct: 61 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120
Query: 121 LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS 180
LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS
Sbjct: 121 LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS 180
Query: 181 CGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQD 240
CGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQD
Sbjct: 181 CGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQD 240
Query: 241 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 300
HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA
Sbjct: 241 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 300
Query: 301 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360
DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW
Sbjct: 301 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360
Query: 361 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK 420
GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK
Sbjct: 361 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK 420
Query: 421 NIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI 464
NIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 421 NIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI 464
>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 561 bits (1445), Expect = e-160
Identities = 266/267 (99%), Positives = 266/267 (99%)
Query: 198 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 257
MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 258 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 317
ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 318 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 377
VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
Query: 378 EMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
EMIPPTLFGLTEFNPEIQVSRIRCGLS FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
Query: 438 WRVTMPGEPVDVACGVDHMVTLAKSFI 464
WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
Score = 58.9 bits (141), Expect = 9e-09
Identities = 63/206 (30%), Positives = 93/206 (45%), Gaps = 26/206 (12%)
Query: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVV 233
+V+QV+CG+ HSL LTD+ V+S G + GQ G + I S ++ D G V+
Sbjct: 34 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTG--LGHYNITSSPTKLG--GDLAGVNVI 89
Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS-----PTKLGGDLAGVNVIQV 288
QVA D L ++ G ++ GWG L ++T S P L G V Q
Sbjct: 90 QVATYGDCCLAVSADGGLF--GWGNSEYLQLA--SVTDSTQVNVPRCLHFSGVG-KVRQA 144
Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--------HFSGVGKVRQ 340
A G C ++ +G +F WG Y L + + VP + F+ +V +
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201
Query: 341 AACGGTGCAVLNGEGHVFVWGYGILG 366
CG + A L +G +FVWG I G
Sbjct: 202 IRCGLSRFAALTNKGELFVWGKNIRG 227
Score = 34.7 bits (78), Expect = 0.19
Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 19/140 (13%)
Query: 108 KISSAACG-YGFTLLSSKTADVTKVWGMG-LNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165
K+ AACG G +L+ + VWG G L K L ++ P+
Sbjct: 140 KVRQAACGGTGCAVLNGEGH--VFVWGYGILGKGPNL--------VESAVPEMIPPTLFG 189
Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225
L P E +V ++ CG + LT++ +F G N G G +E++ + RV
Sbjct: 190 LTEFNP-EIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF--PWRV--- 243
Query: 226 QDFDGQVVQVACGQDHSLFL 245
G+ V VACG DH + L
Sbjct: 244 -TMPGEPVDVACGVDHMVTL 262
>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 561 bits (1445), Expect = e-160
Identities = 266/267 (99%), Positives = 266/267 (99%)
Query: 198 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 257
MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 1 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60
Query: 258 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 317
ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 61 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120
Query: 318 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 377
VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180
Query: 378 EMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
EMIPPTLFGLTEFNPEIQVSRIRCGLS FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240
Query: 438 WRVTMPGEPVDVACGVDHMVTLAKSFI 464
WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267
Score = 58.9 bits (141), Expect = 9e-09
Identities = 63/206 (30%), Positives = 93/206 (45%), Gaps = 26/206 (12%)
Query: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVV 233
+V+QV+CG+ HSL LTD+ V+S G + GQ G + I S ++ D G V+
Sbjct: 34 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTG--LGHYNITSSPTKLG--GDLAGVNVI 89
Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS-----PTKLGGDLAGVNVIQV 288
QVA D L ++ G ++ GWG L ++T S P L G V Q
Sbjct: 90 QVATYGDCCLAVSADGGLF--GWGNSEYLQLA--SVTDSTQVNVPRCLHFSGVG-KVRQA 144
Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--------HFSGVGKVRQ 340
A G C ++ +G +F WG Y L + + VP + F+ +V +
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201
Query: 341 AACGGTGCAVLNGEGHVFVWGYGILG 366
CG + A L +G +FVWG I G
Sbjct: 202 IRCGLSRFAALTNKGELFVWGKNIRG 227
Score = 34.7 bits (78), Expect = 0.19
Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 19/140 (13%)
Query: 108 KISSAACG-YGFTLLSSKTADVTKVWGMG-LNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165
K+ AACG G +L+ + VWG G L K L ++ P+
Sbjct: 140 KVRQAACGGTGCAVLNGEGH--VFVWGYGILGKGPNL--------VESAVPEMIPPTLFG 189
Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225
L P E +V ++ CG + LT++ +F G N G G +E++ + RV
Sbjct: 190 LTEFNP-EIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF--PWRV--- 243
Query: 226 QDFDGQVVQVACGQDHSLFL 245
G+ V VACG DH + L
Sbjct: 244 -TMPGEPVDVACGVDHMVTL 262
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 122 bits (307), Expect = 5e-28
Identities = 83/239 (34%), Positives = 118/239 (49%), Gaps = 16/239 (6%)
Query: 229 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288
D V +VACG +HS+FL + GEVY+CG GQ LGH + P ++G LA ++I V
Sbjct: 33 DRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQ--LGHEREGNKPEQIGA-LADQHIIHV 89
Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 348
A LA+S G LF WG QL +T V VPR + + Q +CG C
Sbjct: 90 ACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHC 149
Query: 349 AVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSH 405
L +G F WG +G LG G A P+ + +L G I ++++ G +H
Sbjct: 150 LALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRV-RSLEG-------IPLAQVAAGGAH 201
Query: 406 FAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM--PGEPVDVACGVDHMVTLAKS 462
AL+ G +F WG N G LG+ +D+ P V + + V ++CG +H L KS
Sbjct: 202 SFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKS 260
Score = 112 bits (281), Expect = 5e-25
Identities = 98/328 (29%), Positives = 152/328 (46%), Gaps = 34/328 (10%)
Query: 106 DQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165
D+ + ACG ++ + +V + GLN QLG R +P +
Sbjct: 33 DRSVKEVACGGNHSVFLLEDGEV---YTCGLNTKGQLGHEREGN----------KPEQIG 79
Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225
D+ ++ V+CG +HSL L+DR +FS G S GQ G E+ + V R+
Sbjct: 80 ALADQ----HIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSV-----AVPRL 130
Query: 226 -QDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLG-HYNITSSPTKLGGDLAG 282
Q + Q ++QV+CG H L L G+ ++ G + GQ GLG + +SP ++ L G
Sbjct: 131 IQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRV-RSLEG 189
Query: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342
+ + QVA G A+S G +FGWG + QL ++D P + KV +
Sbjct: 190 IPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQL-GLSDEKDRESPCHVKLLRTQKVVYIS 248
Query: 343 CGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 402
CG AVL G VF +G G G+ + +S E+ P + L +V++I CG
Sbjct: 249 CGEEHTAVLTKSGGVFTFGAGSCGQLGH--DSMNDEVNPRRVLELM----GSEVTQIACG 302
Query: 403 LSH-FAALTNKGELFVWGKNIRGCLGIG 429
H A + + G ++ +G RG LG G
Sbjct: 303 RQHTLAFVPSSGLIYAFGCGARGQLGTG 330
Score = 80.9 bits (198), Expect = 2e-15
Identities = 68/218 (31%), Positives = 100/218 (45%), Gaps = 34/218 (15%)
Query: 62 FVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLL 121
F WG + G LG+ PS R R ++ +P L Q + A + +L
Sbjct: 159 FTWGKNSHGQLGLGK-EFPSQASPQRV-----RSLEGIP----LAQVAAGGAHSFALSLS 208
Query: 122 SSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSC 181
+ V+G G+N QLG KD+ SP + L R Q +V+ +SC
Sbjct: 209 GA-------VFGWGMNNAGQLGLS-DEKDRE---------SPCHVKLLRTQ--KVVYISC 249
Query: 182 GRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDH 241
G H+ VLT GVF+ G S GQ G + +E+ RV ++ +V Q+ACG+ H
Sbjct: 250 GEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEV--NPRRV--LELMGSEVTQIACGRQH 305
Query: 242 SL-FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGG 278
+L F+ G +Y+ G GA GQ G GH P+ + G
Sbjct: 306 TLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343
Score = 52.8 bits (125), Expect = 7e-07
Identities = 39/137 (28%), Positives = 58/137 (42%), Gaps = 11/137 (8%)
Query: 327 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFG 386
P+ F V++ ACGG L +G V+ G G+ + E PE I
Sbjct: 25 PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL--- 81
Query: 387 LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP 446
+ + + CG SH AL+++G+LF WG G LG+ ED R+
Sbjct: 82 -----ADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQ 136
Query: 447 ---VDVACGVDHMVTLA 460
+ V+CG H + LA
Sbjct: 137 QTILQVSCGNWHCLALA 153
Score = 41.2 bits (95), Expect = 0.002
Identities = 32/111 (28%), Positives = 47/111 (42%), Gaps = 24/111 (21%)
Query: 360 WGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419
WGY LG+ P + + + P + G F + V + CG +H L GE++ G
Sbjct: 4 WGYWSLGQ-PGISTNLQGIVAEPQVCG---FISDRSVKEVACGGNHSVFLLEDGEVYTCG 59
Query: 420 KNIRGCLG----------IGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLA 460
N +G LG IG L DQ+ + VACG H + L+
Sbjct: 60 LNTKGQLGHEREGNKPEQIGALADQHI----------IHVACGESHSLALS 100
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 120 bits (302), Expect = 2e-27
Identities = 106/348 (30%), Positives = 154/348 (44%), Gaps = 28/348 (8%)
Query: 105 LDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPV 164
+++++ CG T+ D V+ G N QLG +SRK +P V
Sbjct: 32 INKRVRDVGCGLRHTVF---VLDDGTVYTCGCNDLGQLGHEKSRK----------KPEQV 78
Query: 165 SLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHR 224
+ LD ++ VSCG AH+L L D+ V++ G +S GQ G V E +
Sbjct: 79 -VALDAQN---IVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL-VGSEECIRVPRNIKS 133
Query: 225 MQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284
+ D Q+VQVACG HSL L+ EV+ G GQ GLG + +L L G+
Sbjct: 134 LSDI--QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIP 191
Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
+QVA G ++ G +FGWG +++ QL + D VP L K+ CG
Sbjct: 192 FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GLNDENDRYVPNLLKSLRSQKIVYICCG 250
Query: 345 GTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLS 404
A L EG VF +G G G G S E+ P +F L V+ I CG
Sbjct: 251 EDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHEINPRKVFELM----GSIVTEIACGRQ 304
Query: 405 HFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVAC 451
H +A + + G ++ +G G LG G ++ P+ V P + C
Sbjct: 305 HTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQC 352
Score = 108 bits (269), Expect = 1e-23
Identities = 86/270 (31%), Positives = 126/270 (46%), Gaps = 22/270 (8%)
Query: 199 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 256
GN S+GQ G ++ EI E R DF + +V V CG H++F+ D G VY+CG
Sbjct: 5 GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 257 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 316
GQ LGH P ++ L N++ V+ LA++ G ++ WG QL
Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Query: 317 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 373
V + VPR + ++ Q ACG L+ VF WG YG LG G + +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177
Query: 374 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLED 433
P+++ +L G+ P +QV+ G +H LT G +F WG+N G LG+ D
Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229
Query: 434 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 461
+Y P + + V + CG DH L K
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259
Score = 73.2 bits (178), Expect = 5e-13
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 40/228 (17%)
Query: 56 ARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACG 115
++A VF WG + G LG+ + + P + + + +P+ Q + A
Sbjct: 153 SKASEVFCWGQNKYGQLGLGTDCKKQTSP------QLLKSLLGIPFM----QVAAGGAHS 202
Query: 116 YGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETR 175
+ TL + ++G G NK QLG + D+ Y V L + +
Sbjct: 203 FVLTLSGA-------IFGWGRNKFGQLGLN----DENDRY--------VPNLLKSLRSQK 243
Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD--GQVV 233
++ + CG H+ LT GVF+ G YGQ G S SH ++ + F+ G +V
Sbjct: 244 IVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN-------STSHEINPRKVFELMGSIV 296
Query: 234 -QVACGQDH-SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279
++ACG+ H S F+ G +YS G G +GQ G G + SP + G+
Sbjct: 297 TEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGN 344
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 120 bits (302), Expect = 2e-27
Identities = 106/348 (30%), Positives = 154/348 (44%), Gaps = 28/348 (8%)
Query: 105 LDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPV 164
+++++ CG T+ D V+ G N QLG +SRK +P V
Sbjct: 32 INKRVRDVGCGLRHTVF---VLDDGTVYTCGCNDLGQLGHEKSRK----------KPEQV 78
Query: 165 SLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHR 224
+ LD ++ VSCG AH+L L D+ V++ G +S GQ G V E +
Sbjct: 79 -VALDAQN---IVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL-VGSEECIRVPRNIKS 133
Query: 225 MQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284
+ D Q+VQVACG HSL L+ EV+ G GQ GLG + +L L G+
Sbjct: 134 LSDI--QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIP 191
Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
+QVA G ++ G +FGWG +++ QL + D VP L K+ CG
Sbjct: 192 FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GLNDENDRYVPNLLKSLRSQKIVYICCG 250
Query: 345 GTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLS 404
A L EG VF +G G G G S E+ P +F L V+ I CG
Sbjct: 251 EDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHEINPRKVFELM----GSIVTEIACGRQ 304
Query: 405 HFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVAC 451
H +A + + G ++ +G G LG G ++ P+ V P + C
Sbjct: 305 HTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQC 352
Score = 108 bits (269), Expect = 1e-23
Identities = 86/270 (31%), Positives = 126/270 (46%), Gaps = 22/270 (8%)
Query: 199 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 256
GN S+GQ G ++ EI E R DF + +V V CG H++F+ D G VY+CG
Sbjct: 5 GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60
Query: 257 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 316
GQ LGH P ++ L N++ V+ LA++ G ++ WG QL
Sbjct: 61 NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Query: 317 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 373
V + VPR + ++ Q ACG L+ VF WG YG LG G + +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177
Query: 374 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLED 433
P+++ +L G+ P +QV+ G +H LT G +F WG+N G LG+ D
Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229
Query: 434 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 461
+Y P + + V + CG DH L K
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259
Score = 73.2 bits (178), Expect = 5e-13
Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 40/228 (17%)
Query: 56 ARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACG 115
++A VF WG + G LG+ + + P + + + +P+ Q + A
Sbjct: 153 SKASEVFCWGQNKYGQLGLGTDCKKQTSP------QLLKSLLGIPFM----QVAAGGAHS 202
Query: 116 YGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETR 175
+ TL + ++G G NK QLG + D+ Y V L + +
Sbjct: 203 FVLTLSGA-------IFGWGRNKFGQLGLN----DENDRY--------VPNLLKSLRSQK 243
Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD--GQVV 233
++ + CG H+ LT GVF+ G YGQ G S SH ++ + F+ G +V
Sbjct: 244 IVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN-------STSHEINPRKVFELMGSIV 296
Query: 234 -QVACGQDH-SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279
++ACG+ H S F+ G +YS G G +GQ G G + SP + G+
Sbjct: 297 TEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGN 344
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 105 bits (262), Expect = 9e-23
Identities = 85/283 (30%), Positives = 130/283 (45%), Gaps = 12/283 (4%)
Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ- 234
+LQ + G HSL+L V S G+NS GQ GR+ + E +Q + +V
Sbjct: 25 LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEP-----IQALETLIVDL 79
Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294
V+CG++HSL + KG V++ G G++GQ G+G + S K L + +IQV+
Sbjct: 80 VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
Query: 295 CLAVSADGGLFGWGNSEYLQLASVTD-STQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
LA+S D +F WG + + QL + +Q + R G+ + Q A GG L+
Sbjct: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGI-PLAQVAAGGAHSFALSL 198
Query: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413
G F WG G+ + + P G + + V I CG +H A LT G
Sbjct: 199 CGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALK---NLGVVYISCGDAHTAVLTQDG 255
Query: 414 ELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVDVACGVDH 455
++F +G N G LG ++ P V + G + CG H
Sbjct: 256 KVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYH 298
Score = 63.9 bits (154), Expect = 3e-10
Identities = 94/348 (27%), Positives = 143/348 (41%), Gaps = 47/348 (13%)
Query: 26 WTAARRSRSRREAAEAEAEVPVVQYVGERAARA----DRVFVWGFSFSGALGVPSFVVPS 81
W A R RR A + + GER + RV G + G LG
Sbjct: 5 WGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLG-------- 56
Query: 82 SGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQ 141
R GA+ R P P + + +CG +L V WG G + Q
Sbjct: 57 -----RRGAQ--RGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVF-AWGAG--SEGQ 106
Query: 142 LGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNN 201
LG + E P + D +++QVSCG HSL L+ VFS G N
Sbjct: 107 LGIGEFK-------EISFTPKKIMTLND----IKIIQVSCGHYHSLALSKDSQVFSWGKN 155
Query: 202 SYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADG 260
S+GQ G + E S++ R++ +G + QVA G HS L+ G + G + G
Sbjct: 156 SHGQLG---LGKEFPSQA-SPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAG 211
Query: 261 QTGLGHYNI---TSSPTKLGGDLAGVNVIQVATYGDCCLAV-SADGGLFGWGNSEYLQLA 316
Q L N+ ++ P +G L + V+ ++ GD AV + DG +F +G++ QL
Sbjct: 212 QLALSGRNVPVQSNKPLSVGA-LKNLGVVYISC-GDAHTAVLTQDGKVFTFGDNRSGQL- 268
Query: 317 SVTDSTQVNVPRCLHFSGVGKVRQAACGG-TGCAVLNGEGHVFVWGYG 363
+ + + P+ + G V Q CG A ++ G V +G+G
Sbjct: 269 GYSPTPEKRGPQLVERID-GLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 102 bits (254), Expect = 7e-22
Identities = 81/273 (29%), Positives = 132/273 (48%), Gaps = 26/273 (9%)
Query: 177 LQVSCGR-AHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQ 234
L SCG HS+ LT+ VFS G+ YG+ G + + R +++ G+ VVQ
Sbjct: 4084 LVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQ-----RRPRQIEALQGEEVVQ 4138
Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294
++CG HS +T G++++ G G G+ GLG+ + P ++ L G + QVA +
Sbjct: 4139 MSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNH 4197
Query: 295 CLAVSADGGL-FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
LAVSADG + + +G+ +Y +L + + + + G+G +++ ACG L
Sbjct: 4198 TLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIG-IKKVACGTQFSVALTK 4256
Query: 354 EGHVFVWGYGIL-----GKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAA 408
+GHV+ +G L G+ N P+ IP L G+ + + G H A
Sbjct: 4257 DGHVYTFGQDRLIGLPEGRARNHNR---PQQIP-VLAGVI-------IEDVAVGAEHTLA 4305
Query: 409 LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 441
L + G+++ WG N G LG+G P VT
Sbjct: 4306 LASNGDVYAWGSNSEGQLGLGHTNHVREPTLVT 4338
Score = 94.7 bits (234), Expect = 2e-19
Identities = 85/307 (27%), Positives = 143/307 (46%), Gaps = 22/307 (7%)
Query: 164 VSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVH 223
V +P P ++ QV CG+ + V+ V + G SYG+ G+ ++ +
Sbjct: 4017 VMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQG--NSDDLHVLTVIS 4074
Query: 224 RMQDFDGQVVQVACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAG 282
+Q F + +CG D HS+ LT+ GEV+S G G G+ G G+ + P ++ L G
Sbjct: 4075 ALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEA-LQG 4133
Query: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342
V+Q++ V++DG LF +GN +Y +L S + R G ++ Q A
Sbjct: 4134 EEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGY-QIGQVA 4192
Query: 343 CGGTGCAVLNGEGHVFVWG-----YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVS 397
CG ++ +G + VW YG LG G + +S+ P+ I L G I +
Sbjct: 4193 CGLNHTLAVSADGSM-VWAFGDGDYGKLGLGNSTAKSS-PQKI-DVLCG-------IGIK 4242
Query: 398 RIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV--DVACGVDH 455
++ CG ALT G ++ +G++ L GR + P ++ + + DVA G +H
Sbjct: 4243 KVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEH 4302
Query: 456 MVTLAKS 462
+ LA +
Sbjct: 4303 TLALASN 4309
Score = 79.7 bits (195), Expect = 5e-15
Identities = 75/244 (30%), Positives = 112/244 (45%), Gaps = 21/244 (8%)
Query: 172 QETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ 231
Q V+Q+SCG HS V+T +F+ GN YG+ G N+ E RV ++ + Q
Sbjct: 4132 QGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPE--RVTALEGY--Q 4187
Query: 232 VVQVACGQDHSLFLTDKGE-VYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290
+ QVACG +H+L ++ G V++ G G G+ GLG+ SSP K+ L G+ + +VA
Sbjct: 4188 IGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKI-DVLCGIGIKKVAC 4246
Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAV 350
+A++ DG ++ +G + L + N P+ + + A G
Sbjct: 4247 GTQFSVALTKDGHVYTFGQDRLIGLPE-GRARNHNRPQQIPVLAGVIIEDVAVGAEHTLA 4305
Query: 351 LNGEGHVFVWG---YGILGKG-PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHF 406
L G V+ WG G LG G N V P + GL N V +I G H
Sbjct: 4306 LASNGDVYAWGSNSEGQLGLGHTNHVRE------PTLVTGLQGKN----VRQISAGRCHS 4355
Query: 407 AALT 410
AA T
Sbjct: 4356 AAWT 4359
Score = 78.2 bits (191), Expect = 1e-14
Identities = 72/250 (28%), Positives = 112/250 (44%), Gaps = 23/250 (9%)
Query: 185 HSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ-VACGQDHSL 243
H+L T VFS G+ YG+ G + Y + + G+VV V+ G HS
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQ----GPLQGKVVVCVSAGYRHSA 524
Query: 244 FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGG 303
+T+ GE+Y+ G G G+ G G N + PT L D++ NV +V+ +A+S DG
Sbjct: 525 AVTEDGELYTWGEGDFGRLGHGDSNSRNIPT-LVKDIS--NVGEVSCGSSHTIALSKDGR 581
Query: 304 L---FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360
FG G++ L D+ +V P+ + +R+ G L G V+ W
Sbjct: 582 TVWSFGGGDNGKLGHG---DTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638
Query: 361 GYGI-LGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419
G G LG G + + P++I E ++ + G SH AL++ E++ WG
Sbjct: 639 GCGACLGCGSSEATALRPKLI--------EELAATRIVDVSIGDSHCLALSHDNEVYAWG 690
Query: 420 KNIRGCLGIG 429
N G G G
Sbjct: 691 NNSMGQCGQG 700
Score = 74.7 bits (182), Expect = 2e-13
Identities = 69/260 (26%), Positives = 113/260 (43%), Gaps = 23/260 (8%)
Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE-----IYSESHRVHRMQDFDGQVV 233
+ G+ + V++ V + G SYG+ G N+ + E HR + V
Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKK-------V 460
Query: 234 QVACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292
+ G D H+L T +GEV+S G G G+ G G+ + P + G L G V+ V+
Sbjct: 461 SSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGY 520
Query: 293 DCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLN 352
AV+ DG L+ WG ++ +L DS N+P + + V + +CG + L+
Sbjct: 521 RHSAAVTEDGELYTWGEGDFGRLGH-GDSNSRNIPTLV--KDISNVGEVSCGSSHTIALS 577
Query: 353 GEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412
+G VW +G G L + P + E + + ++ G ALT+
Sbjct: 578 KDGRT-VWSFG-GGDNGKLGHGDTNRVYKPKVI---EALQGMFIRKVCAGSQSSLALTST 632
Query: 413 GELFVWGKNIRGCLGIGRLE 432
G+++ WG CLG G E
Sbjct: 633 GQVYAWG--CGACLGCGSSE 650
Score = 68.6 bits (166), Expect = 1e-11
Identities = 45/160 (28%), Positives = 77/160 (48%), Gaps = 15/160 (9%)
Query: 174 TRVLQVSCGRAHSLVLT-DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHR---MQDFD 229
+ V +VSCG +H++ L+ D V+S G G+ G + +++RV++ ++
Sbjct: 561 SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLG--------HGDTNRVYKPKVIEALQ 612
Query: 230 GQVVQVAC-GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288
G ++ C G SL LT G+VY+ WG G G T+ KL +LA ++ V
Sbjct: 613 GMFIRKVCAGSQSSLALTSTGQVYA--WGCGACLGCGSSEATALRPKLIEELAATRIVDV 670
Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 328
+ CLA+S D ++ WGN+ Q + + P+
Sbjct: 671 SIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPK 710
Score = 67.4 bits (163), Expect = 3e-11
Identities = 74/267 (27%), Positives = 108/267 (40%), Gaps = 38/267 (14%)
Query: 210 VVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNI 269
V E+E+ + D Q++ A + L K +VY G G GQ N+
Sbjct: 3958 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNV 4017
Query: 270 TSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG----------GLFGWGNSEYLQLASVT 319
A QV +C + A+G G G GNS+ L + +V
Sbjct: 4018 MVPAAAPSFSQAQ----QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 4073
Query: 320 DSTQVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESA 375
+ Q V L S CG G ++ L G VF WG YG LG G N
Sbjct: 4074 SALQGFVVTQLVTS---------CGSDGHSMALTESGEVFSWGDGDYGKLGHG-NSDRQR 4123
Query: 376 VPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQY 435
P I E +V ++ CG H A +T+ G+LF +G G LG+G ++
Sbjct: 4124 RPRQI--------EALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 4175
Query: 436 FPWRVT-MPGEPV-DVACGVDHMVTLA 460
P RVT + G + VACG++H + ++
Sbjct: 4176 LPERVTALEGYQIGQVACGLNHTLAVS 4202
Score = 66.6 bits (161), Expect = 4e-11
Identities = 63/218 (28%), Positives = 85/218 (38%), Gaps = 18/218 (8%)
Query: 250 EVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGN 309
EVY G + Q G P KL + I+ Y C +S DG + G
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQP-KLAPSFSDAQTIEAGQY--CTFVISTDGSVRACGK 429
Query: 310 SEYLQLASVTDSTQVNVPRCLHFS---GVGKVRQAACGGTGCAVLNGEGHVFVWG---YG 363
Y +L + DS + + L F + KV + EG VF WG YG
Sbjct: 430 GSYGRLG-LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYG 488
Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
LG G N P++I L G V + G H AA+T GEL+ WG+
Sbjct: 489 KLGHG-NSSTQKYPKLIQGPLQGKV-------VVCVSAGYRHSAAVTEDGELYTWGEGDF 540
Query: 424 GCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAK 461
G LG G + P V +V+CG H + L+K
Sbjct: 541 GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSK 578
Score = 63.5 bits (153), Expect = 4e-10
Identities = 59/195 (30%), Positives = 87/195 (44%), Gaps = 36/195 (18%)
Query: 108 KISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLP 167
+I ACG TL S AD + VW G +LG S +
Sbjct: 4187 QIGQVACGLNHTLAVS--ADGSMVWAFGDGDYGKLGLGNSTAKSS--------------- 4229
Query: 168 LDRPQETRVL------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESH- 220
PQ+ VL +V+CG S+ LT V++ G + R + E + +H
Sbjct: 4230 ---PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQD------RLIGLPEGRARNHN 4280
Query: 221 RVHRMQDFDGQVVQ-VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279
R ++ G +++ VA G +H+L L G+VY+ G ++GQ GLGH N PT + G
Sbjct: 4281 RPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG- 4339
Query: 280 LAGVNVIQVATYGDC 294
L G NV Q++ G C
Sbjct: 4340 LQGKNVRQISA-GRC 4353
Score = 43.5 bits (101), Expect = 4e-04
Identities = 48/203 (23%), Positives = 83/203 (40%), Gaps = 21/203 (10%)
Query: 99 VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158
+P ++ + +CG T+ SK D VW G + +LG D R Y+
Sbjct: 553 IPTLVKDISNVGEVSCGSSHTIALSK--DGRTVWSFGGGDNGKLG----HGDTNRVYKPK 606
Query: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218
+ ++ Q + +V G SL LT V++ G + CG +
Sbjct: 607 V--------IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSE------AT 652
Query: 219 SHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
+ R +++ ++V V+ G H L L+ EVY+ G + GQ G G+ + K
Sbjct: 653 ALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKV 712
Query: 278 GDLAGVNVIQVATYGDCCLAVSA 300
L G+ + Q++ LA +A
Sbjct: 713 SGLDGIAIQQISAGTSHSLAWTA 735
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 100 bits (250), Expect = 2e-21
Identities = 80/259 (30%), Positives = 119/259 (45%), Gaps = 20/259 (7%)
Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREG-VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQ 226
LD ++ +S G +VL EG VF+ G+N+Y Q G + + H
Sbjct: 92 LDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVP----CHIST 147
Query: 227 DFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNV 285
+ QV++VACG HSL LT GEV++ G+ GQ G G P ++ G L V
Sbjct: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV 207
Query: 286 IQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGG 345
+ +A CC+AV G ++ WG + QL Q R G+ +V++ ACG
Sbjct: 208 VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGI-RVQRVACGY 266
Query: 346 TGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 402
VL EG V+ WG YG LG G N + P + E + I+++ C
Sbjct: 267 AHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPV------TVEKDRIIEIA--ACH 317
Query: 403 LSH-FAALTNKGELFVWGK 420
+H AA T G +++WG+
Sbjct: 318 STHTSAAKTQGGHVYMWGQ 336
Score = 99.4 bits (246), Expect = 6e-21
Identities = 83/283 (29%), Positives = 135/283 (47%), Gaps = 29/283 (10%)
Query: 172 QETRVLQVSC--GRAHSLVL--TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227
+E ++++ +C G A + VL T + +F +G N G G V++ I R+
Sbjct: 40 EELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI-----EPRRLDS 94
Query: 228 FDGQVVQVAC----GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283
+G+ ++AC H + T +GEV++ G A Q G G N P + +L+
Sbjct: 95 LNGK--KIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNK 152
Query: 284 NVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR----CLHFSGVGKVR 339
VI+VA L +++DG +F WG + Q+ S + Q +PR CL V +
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQP-IPRRVTGCLQNKVVVTI- 210
Query: 340 QAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRI 399
ACG C + G V+VWGY G G + ++ + P + L I+V R+
Sbjct: 211 --ACGQMCCMAVVDTGEVYVWGYN--GNGQLGLGNSGNQPTPCRVAALQG----IRVQRV 262
Query: 400 RCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 442
CG +H LT++G+++ WG N G LG G +Q +P VT+
Sbjct: 263 ACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV 305
Score = 39.3 bits (90), Expect = 0.008
Identities = 43/154 (27%), Positives = 66/154 (42%), Gaps = 39/154 (25%)
Query: 61 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQ--KISSAACGYGF 118
V+VWG++ +G LG + +SG QP P R+ Q ++ ACGY
Sbjct: 226 VYVWGYNGNGQLG-----LGNSGN------------QPTPCRVAALQGIRVQRVACGYAH 268
Query: 119 TLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQ 178
TL+ D +V+ G N QLG + + Y P+PV++ DR E
Sbjct: 269 TLV---LTDEGQVYAWGANSYGQLG---TGNKSNQSY-----PTPVTVEKDRIIEI---- 313
Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQC-GRKVV 211
+C H+ + G M +GQC G+ V+
Sbjct: 314 AACHSTHTSAAKTQGGHVYM----WGQCRGQSVI 343
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 92.8 bits (229), Expect = 6e-19
Identities = 81/289 (28%), Positives = 133/289 (46%), Gaps = 29/289 (10%)
Query: 171 PQETRVLQVSC----GRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQ 226
PQE ++ +C + +L +TD + VF G N G ++ + + +++
Sbjct: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPK-----KLE 69
Query: 227 DFDGQVVQ-VACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284
G+ ++ ++ G H L T+ G VY+ G Q G G N +P ++ +L
Sbjct: 70 GLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQ 129
Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQV---NVPRCLHFSGVGKVRQA 341
V++VA +A++ADG +F WG + Q+ S + + Q V CLH + +V
Sbjct: 130 VVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGI 186
Query: 342 ACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 398
ACG T + G V+ WGY G LG G N ++ P + L + V++
Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-----GNQLTPVRVAAL----HSVCVNQ 237
Query: 399 IRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV 447
I CG +H ALT++G L+ WG N G LG G + P + + E V
Sbjct: 238 IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERV 286
Score = 57.4 bits (137), Expect = 3e-08
Identities = 45/159 (28%), Positives = 67/159 (42%), Gaps = 13/159 (8%)
Query: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
RV+ ++CG+ S+ + D V+ G N GQ G N++ RV + V Q
Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPV--RVAALHSVC--VNQ 237
Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294
+ CG H+L LTD+G +Y+ G GQ G G+ N SP + + V I
Sbjct: 238 IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHT 297
Query: 295 CLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 333
A + G ++ WG V +P HFS
Sbjct: 298 SAAKTQGGHVYMWGQCR---------GQSVILPHLTHFS 327
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 90.1 bits (222), Expect = 4e-18
Identities = 88/289 (30%), Positives = 125/289 (43%), Gaps = 28/289 (9%)
Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQCG---RKVVENEIYSESHRVHRMQDFDGQVVQV 235
V G H+ LT VFS G G+ G R + E+ + R++D +
Sbjct: 3052 VHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRD-------I 3104
Query: 236 ACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVA--TYGD 293
ACG HS LT GE+Y+ G G G+ G G N T K+ L G VIQVA +
Sbjct: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGD-NTTQLKPKMVKVLLGHRVIQVACGSRDA 3163
Query: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
LA++ +G +F WG+ ++ +L S N+P+ + V Q CG L
Sbjct: 3164 QTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTK 3222
Query: 354 EGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410
G V+ WG Y LG G S V P + GL ++ + G H A+T
Sbjct: 3223 SGVVWTWGKGDYFRLGHG-----SDVHVRKPQVVEGLR----GKKIVHVAVGALHCLAVT 3273
Query: 411 NKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPVD-VACGVDHMV 457
+ G+++ WG N G G G P V + G+ + VACG H V
Sbjct: 3274 DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3322
Score = 88.2 bits (217), Expect = 1e-17
Identities = 82/290 (28%), Positives = 123/290 (42%), Gaps = 40/290 (13%)
Query: 130 KVWGMGLNKDSQLG-FHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLV 188
KV+ G D +LG F R DK R E + + R+ ++CG +HS
Sbjct: 3067 KVFSWGEGDDGKLGHFSRMNCDKPRLIEAL-------------KTKRIRDIACGSSHSAA 3113
Query: 189 LTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV---HRMQDFDGQVVQVACG--QDHSL 243
LT +++ G YG+ G ++ + +V HR V+QVACG +L
Sbjct: 3114 LTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHR-------VIQVACGSRDAQTL 3166
Query: 244 FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGG 303
LTD+G V+S G G G+ G G + P + L G V Q+ LA++ G
Sbjct: 3167 ALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNI-ERLNGQGVCQIECGAQFSLALTKSGV 3225
Query: 304 LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG-- 361
++ WG +Y +L +D V P+ + K+ A G C + G V+ WG
Sbjct: 3226 VWTWGKGDYFRLGHGSD-VHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDN 3284
Query: 362 -YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410
+G G G V PTL E +++R+ CG SH A T
Sbjct: 3285 DHGQQGNGTTTVNR------KPTLVQGLEGQ---KITRVACGSSHSVAWT 3325
Score = 87.4 bits (215), Expect = 2e-17
Identities = 83/304 (27%), Positives = 124/304 (40%), Gaps = 48/304 (15%)
Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNS--------YGQCGRKVVENEIYSESHRVHRMQD 227
V Q++C L+L+ V++ NS G R +V+ +S+ H
Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLVQGLASRNIVKIAAHSDGH------- 505
Query: 228 FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP---TKLGGDLAGVN 284
H L L GEVYS G G G+ G G P + G AG +
Sbjct: 506 -------------HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKH 552
Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
V+ +A A++A+G L+ WG Y +L + + G+ KV ACG
Sbjct: 553 VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACG 611
Query: 345 GTGCAVL--NGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRI 399
L G V+ WG YG LG+G + P++I E ++ V ++
Sbjct: 612 SGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLI--------EKLQDLDVVKV 662
Query: 400 RCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 457
RCG ALT G+++ WGK LG G E +P + + G+ V DVA G H +
Sbjct: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCL 722
Query: 458 TLAK 461
L +
Sbjct: 723 ALTE 726
Score = 86.3 bits (212), Expect = 5e-17
Identities = 83/283 (29%), Positives = 127/283 (44%), Gaps = 25/283 (8%)
Query: 190 TDREGVFSMGNNSYGQCGR-KVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDK 248
T R VF G N Q G K + ++ S S + + VVQVA G +T +
Sbjct: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-----VVQVAGGSKSLFAVTVE 3010
Query: 249 GEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY--GDCCLAVSADGGLFG 306
G+VY+CG +G+ GLG + T + L+ V +VA + G A++ DG +F
Sbjct: 3011 GKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFS 3070
Query: 307 WGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YG 363
WG + +L + + PR + ++R ACG + A L G ++ WG YG
Sbjct: 3071 WGEGDDGKLGHFS-RMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG 3129
Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGL--SHFAALTNKGELFVWGKN 421
LG G N + P+M+ L +V ++ CG + ALT++G +F WG
Sbjct: 3130 RLGHGDNTTQ-LKPKMVKVLL--------GHRVIQVACGSRDAQTLALTDEGLVFSWGDG 3180
Query: 422 IRGCLGIGRLEDQYFPWRV-TMPGEPV-DVACGVDHMVTLAKS 462
G LG G E P + + G+ V + CG + L KS
Sbjct: 3181 DFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKS 3223
Score = 80.5 bits (197), Expect = 3e-15
Identities = 69/250 (27%), Positives = 112/250 (44%), Gaps = 20/250 (8%)
Query: 167 PLDRPQETR------VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESH 220
P DRP+ V+ V+ G AHS +T +++ G YG+ G E+++ +
Sbjct: 4078 PCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQL--KPK 4135
Query: 221 RVHRMQDFDGQVVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGG 278
V +Q +VV +ACG +L LTD V+S G G G+ G G + P K+
Sbjct: 4136 LVEALQGH--RVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKI-D 4192
Query: 279 DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 338
L G+ V++V +A++ G ++ WG +Y +L +D V PR + KV
Sbjct: 4193 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDD-HVRRPRQVQGLQGKKV 4251
Query: 339 RQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 398
A G C +G V+ WG G+ + +A+ P L + +V+R
Sbjct: 4252 IAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR---PRLVAALQGK---KVNR 4305
Query: 399 IRCGLSHFAA 408
+ CG +H A
Sbjct: 4306 VACGSAHTLA 4315
Score = 75.5 bits (184), Expect = 1e-13
Identities = 56/204 (27%), Positives = 96/204 (47%), Gaps = 8/204 (3%)
Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSES 219
EP +S + V+ ++CG +S +T +++ G +YG+ G E+E +
Sbjct: 537 EPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE--AIP 594
Query: 220 HRVHRMQDFDGQVVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
V ++ +V+ VACG +L +T+ G+V+S G G G+ G G + +P KL
Sbjct: 595 MLVAGLKGL--KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTP-KLI 651
Query: 278 GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGK 337
L ++V++V +A++ DG ++ WG + +L T+ V P+ L K
Sbjct: 652 EKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEE-HVRYPKLLEGLQGKK 710
Query: 338 VRQAACGGTGCAVLNGEGHVFVWG 361
V A G T C L + V WG
Sbjct: 711 VIDVAAGSTHCLALTEDSEVHSWG 734
Score = 72.8 bits (177), Expect = 6e-13
Identities = 49/142 (34%), Positives = 73/142 (51%), Gaps = 7/142 (4%)
Query: 175 RVLQVSCGR--AHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQV 232
+V+ V+CG A +L +T+ V+S G+ YG+ GR + + ++QD D V
Sbjct: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--CKTPKLIEKLQDLD--V 659
Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292
V+V CG S+ LT G+VYS G G + + G G P L G L G VI VA
Sbjct: 660 VKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG-LQGKKVIDVAAGS 718
Query: 293 DCCLAVSADGGLFGWGNSEYLQ 314
CLA++ D + WG+++ Q
Sbjct: 719 THCLALTEDSEVHSWGSNDQCQ 740
Score = 72.8 bits (177), Expect = 6e-13
Identities = 85/290 (29%), Positives = 124/290 (42%), Gaps = 20/290 (6%)
Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVAC 237
V+ G H L L+ V+S G G+ G N + RV ++ G +VV VA
Sbjct: 4044 VNSGGKHCLALSSEGEVYSWGEAEDGKLGHG---NRSPCDRPRV--IESLRGIEVVDVAA 4098
Query: 238 GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDC-C 295
G HS +T G++Y+ G G G+ G P KL L G V+ +A GD
Sbjct: 4099 GGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKP-KLVEALQGHRVVDIACGSGDAQT 4157
Query: 296 LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLH-FSGVGKVRQAACGGTGCAVLNGE 354
L ++ D ++ WG+ +Y +L S VP + +G+G V+ CG L
Sbjct: 4158 LCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDSLTGLGVVK-VECGSQFSVALTKS 4215
Query: 355 GHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGE 414
G V+ WG G + + + V P + GL +V I G H T GE
Sbjct: 4216 GAVYTWGKGDYHRLGHGSDDHVRR--PRQVQGLQGK----KVIAIATGSLHCVCCTEDGE 4269
Query: 415 LFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGVDHMVTLAKS 462
++ WG N G LG G P V + G+ V+ VACG H + + S
Sbjct: 4270 VYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4319
Score = 71.6 bits (174), Expect = 1e-12
Identities = 72/244 (29%), Positives = 107/244 (43%), Gaps = 20/244 (8%)
Query: 185 HSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-----VVQVACGQ 239
H L L V+S G G+ G + + E +V + F G+ VV +ACG
Sbjct: 506 HYLALAATGEVYSWGCGDGGRLGHG---DTVPLEEPKV--ISAFSGKQAGKHVVHIACGS 560
Query: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDC-CLA 297
+S +T +GE+Y+ G G G+ G G + P + G L G+ VI VA GD LA
Sbjct: 561 TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAG-LKGLKVIDVACGSGDAQTLA 619
Query: 298 VSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHV 357
V+ +G ++ WG+ +Y +L S P+ + V + CG L +G V
Sbjct: 620 VTENGQVWSWGDGDYGKLGR-GGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQV 678
Query: 358 FVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFV 417
+ WG G + + E V P L GL +V + G +H ALT E+
Sbjct: 679 YSWGKGDNQRLGHGTEEHV--RYPKLLEGLQGK----KVIDVAAGSTHCLALTEDSEVHS 732
Query: 418 WGKN 421
WG N
Sbjct: 733 WGSN 736
Score = 65.9 bits (159), Expect = 8e-11
Identities = 77/255 (30%), Positives = 110/255 (43%), Gaps = 21/255 (8%)
Query: 214 EIYSESHRVHRMQDFDGQVVQVACGQ--DHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271
++ ESH + + + D Q+VQ + D +L G +Y G GQ G
Sbjct: 3916 DVLHESHDIFKREQ-DEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVK 3974
Query: 272 SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLH 331
PT LA + +Q+ AV+ADG L+ G +L + + V+ P L
Sbjct: 3975 VPTPCEA-LATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLG-IGGTESVSTPTLLE 4032
Query: 332 FSGVGKVRQAAC--GGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFG 386
+++ A GG C L+ EG V+ WG G LG G N P +I +L G
Sbjct: 4033 SIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHG-NRSPCDRPRVIE-SLRG 4090
Query: 387 LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPG- 444
I+V + G +H A +T G+L+ WGK G LG EDQ P V + G
Sbjct: 4091 -------IEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH 4143
Query: 445 EPVDVACGVDHMVTL 459
VD+ACG TL
Sbjct: 4144 RVVDIACGSGDAQTL 4158
Score = 55.1 bits (131), Expect = 1e-07
Identities = 54/185 (29%), Positives = 78/185 (42%), Gaps = 24/185 (12%)
Query: 108 KISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLP 167
++ ACG G T D T VW G +LG R D + V +
Sbjct: 4144 RVVDIACGSGDAQTLCLTDDDT-VWSWGDGDYGKLG--RGGSDGCK----------VPMK 4190
Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESH--RVHRM 225
+D V++V CG S+ LT V++ G Y + G S+ H R ++
Sbjct: 4191 IDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG-------SDDHVRRPRQV 4243
Query: 226 QDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284
Q G+ V+ +A G H + T+ GEVY+ G +GQ G G N P +L L G
Sbjct: 4244 QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRP-RLVAALQGKK 4302
Query: 285 VIQVA 289
V +VA
Sbjct: 4303 VNRVA 4307
Score = 31.6 bits (70), Expect = 1.6
Identities = 29/100 (29%), Positives = 42/100 (42%), Gaps = 15/100 (15%)
Query: 106 DQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165
D + CG F++ +K V WG G N+ +LG E+V P
Sbjct: 656 DLDVVKVRCGSQFSIALTKDGQVYS-WGKGDNQ--RLGHGTE--------EHVRYPKL-- 702
Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQ 205
L+ Q +V+ V+ G H L LT+ V S G+N Q
Sbjct: 703 --LEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 89.7 bits (221), Expect = 5e-18
Identities = 66/231 (28%), Positives = 113/231 (48%), Gaps = 10/231 (4%)
Query: 209 KVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN 268
K E + YS H + +++Q+ CG HSL L+ GE+++ G GQ G+G
Sbjct: 117 KPFEYDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKF 176
Query: 269 ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 328
+++ ++ LAGV + Q++ +A+S G ++ WG +E QL + + + P
Sbjct: 177 PSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQL-GLGHTESKDDPS 235
Query: 329 CLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGL 387
+ KV ACGG+ A+L +G +F +G G G+ G N ++ + + L G
Sbjct: 236 LIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVG- 294
Query: 388 TEFNPEIQVSRIRCGLSH-FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
+V++I CG H A +++ G++F +G G LG G DQ P
Sbjct: 295 ------YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMP 339
Score = 78.6 bits (192), Expect = 1e-14
Identities = 63/195 (32%), Positives = 96/195 (49%), Gaps = 10/195 (5%)
Query: 172 QETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG- 230
QE +++Q++CG HSL L+ +F+ G N +GQ G + + ++ G
Sbjct: 136 QEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLG----VGRKFPSTTTPQIVEHLAGV 191
Query: 231 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290
+ Q++ G+ HS+ L+ G +YS G GQ GLGH P+ + G L V VA
Sbjct: 192 PLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG-LDNQKVEFVAC 250
Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVG-KVRQAACG-GTGC 348
G ++ DG LF +G ++ QL +STQ + CL VG +V Q ACG
Sbjct: 251 GGSHSALLTQDGLLFTFGAGKHGQLGH--NSTQNELRPCLVAELVGYRVTQIACGRWHTL 308
Query: 349 AVLNGEGHVFVWGYG 363
A ++ G VF +G G
Sbjct: 309 AYVSDLGKVFSFGSG 323
Score = 62.0 bits (149), Expect = 1e-09
Identities = 59/217 (27%), Positives = 98/217 (45%), Gaps = 46/217 (21%)
Query: 56 ARADRVFVWGFSFSGALGV----PSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISS 111
++ +F WG + G LGV PS P + + VP ++
Sbjct: 154 SKGGELFAWGQNLHGQLGVGRKFPSTTTP----------QIVEHLAGVP--------LAQ 195
Query: 112 AACGYGFTLLSSKTADVTKVWGMGLNKDSQLGF-HRSRKDKTRGYEYVLEPSPVSLPLDR 170
+ G ++ S + + ++ G N+ QLG H KD +PS + +
Sbjct: 196 ISAGEAHSMALSMSGN---IYSWGKNECGQLGLGHTESKD---------DPSLI----EG 239
Query: 171 PQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG 230
+V V+CG +HS +LT +F+ G +GQ G +NE+ R + + G
Sbjct: 240 LDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNEL-----RPCLVAELVG 294
Query: 231 -QVVQVACGQDHSL-FLTDKGEVYSCGWGADGQTGLG 265
+V Q+ACG+ H+L +++D G+V+S G G DGQ G G
Sbjct: 295 YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 87.4 bits (215), Expect = 2e-17
Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)
Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
P + + + + A G T+ SK+ +V+ G N + LG R G E V
Sbjct: 77 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 128
Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E
Sbjct: 129 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 176
Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
+ V D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 177 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 236
Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
G V A+S +G ++G+G S Y QL + +
Sbjct: 237 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 296
Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
F K GG V ++ EG + G YG LG G E ++P
Sbjct: 297 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 356
Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
+I VS + CG S A+T G +F WG LG G+ ED + P
Sbjct: 357 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 405
Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
V M G+ ++ V+ G H V L K
Sbjct: 406 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 433
Score = 30.4 bits (67), Expect = 3.6
Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 1/63 (1%)
Query: 401 CGLSHFAALTNKGELFVWGKNIRGCLGIG-RLEDQYFPWRVTMPGEPVDVACGVDHMVTL 459
C +SH + T G + G+ G LG+G + ++ P V++P + V G H V L
Sbjct: 40 CQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCL 99
Query: 460 AKS 462
+KS
Sbjct: 100 SKS 102
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 87.4 bits (215), Expect = 2e-17
Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)
Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
P + + + + A G T+ SK+ +V+ G N + LG R G E V
Sbjct: 91 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 142
Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E
Sbjct: 143 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 190
Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
+ V D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 191 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 250
Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
G V A+S +G ++G+G S Y QL + +
Sbjct: 251 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 310
Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
F K GG V ++ EG + G YG LG G E ++P
Sbjct: 311 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 370
Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
+I VS + CG S A+T G +F WG LG G+ ED + P
Sbjct: 371 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 419
Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
V M G+ ++ V+ G H V L K
Sbjct: 420 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 447
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 87.4 bits (215), Expect = 2e-17
Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)
Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
P + + + + A G T+ SK+ +V+ G N + LG R G E V
Sbjct: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111
Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E
Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159
Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
+ V D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219
Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
G V A+S +G ++G+G S Y QL + +
Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279
Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
F K GG V ++ EG + G YG LG G E ++P
Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339
Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
+I VS + CG S A+T G +F WG LG G+ ED + P
Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388
Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
V M G+ ++ V+ G H V L K
Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 87.4 bits (215), Expect = 2e-17
Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)
Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
P + + + + A G T+ SK+ +V+ G N + LG R G E V
Sbjct: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111
Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E
Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159
Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
+ V D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219
Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
G V A+S +G ++G+G S Y QL + +
Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279
Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
F K GG V ++ EG + G YG LG G E ++P
Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339
Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
+I VS + CG S A+T G +F WG LG G+ ED + P
Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388
Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
V M G+ ++ V+ G H V L K
Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 87.4 bits (215), Expect = 2e-17
Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)
Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
P + + + + A G T+ SK+ +V+ G N + LG R G E V
Sbjct: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111
Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E
Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159
Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
+ V D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219
Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
G V A+S +G ++G+G S Y QL + +
Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279
Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
F K GG V ++ EG + G YG LG G E ++P
Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339
Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
+I VS + CG S A+T G +F WG LG G+ ED + P
Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388
Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
V M G+ ++ V+ G H V L K
Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 87.4 bits (215), Expect = 2e-17
Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)
Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
P + + + + A G T+ SK+ +V+ G N + LG R G E V
Sbjct: 60 PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111
Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
P V L + +V+QVS G +H+ LTD VF G+ ++ G G ++E
Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159
Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
+ V D VV+VA G DH + LT G++Y+ G G GQ G + + G
Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219
Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
G V A+S +G ++G+G S Y QL + +
Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279
Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
F K GG V ++ EG + G YG LG G E ++P
Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339
Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
+I VS + CG S A+T G +F WG LG G+ ED + P
Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388
Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
V M G+ ++ V+ G H V L K
Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 83.6 bits (205), Expect = 4e-16
Identities = 88/342 (25%), Positives = 146/342 (42%), Gaps = 72/342 (21%)
Query: 177 LQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVA 236
+ +SCG HS V+T ++ G+N++GQ G + S+ V ++ +V A
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAA 93
Query: 237 CGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCL 296
CG++H+L T+ G VY+ G +GQ GLG ++ + + + Q++ +
Sbjct: 94 CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSA 153
Query: 297 AVSADGGLFGWGNSEYLQL-----ASVTDSTQVNVPRCLHFSGVG--------------- 336
A++ DG LF WG++ Q+ ++V QV + + + + G
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 337 ------------------------------KVRQAACGGTGCAVLNGEGHVFVWG---YG 363
KV Q ACGG VL E V+ +G +G
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272
Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
LG G L E++ P++I E + +S I CG +H A +T+ G ++ +G
Sbjct: 273 QLGLGTFLFETSEPKVI--------ENIRDQTISYISCGENHTALITDIGLMYTFGDGRH 324
Query: 424 GCLGIGRLEDQYFPWRVTMPGEPVD-----VACGVDHMVTLA 460
G LG+G LE+ + T+ + VACG HMV A
Sbjct: 325 GKLGLG-LENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365
Score = 80.5 bits (197), Expect = 3e-15
Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 22/240 (9%)
Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292
V ++CG +HS +T ++Y G GQ GLG + S PT + +++A G
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKA--LKPEKVKLAACG 95
Query: 293 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 349
VS +GG G N L L + +V F+ K++Q + G A
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153
Query: 350 VLNGEGHVFVWGYGILGKG--PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFA 407
L +G +F+WG G+ N+ VP+ + T P VS I CG H A
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203
Query: 408 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 464
+T GEL+V+G+ G LG+ L + P V+ +P + + VACG +H V L ++ +
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263
Score = 63.2 bits (152), Expect = 5e-10
Identities = 59/243 (24%), Positives = 109/243 (44%), Gaps = 39/243 (16%)
Query: 60 RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119
R+F+WG + G +G+ + VP ++ + + +S +CGY +
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVC-----------------VPQQVTIGKPVSWISCGYYHS 202
Query: 120 LLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQV 179
+ ++ + G ++ +LG R + V E +P +V+QV
Sbjct: 203 AFVTTDGEL---YVFGEPENGKLGLPNQLLGNHRTPQLVSE-----IP------EKVIQV 248
Query: 180 SCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
+CG H++VLT+ V++ G +GQ G E SE + ++D + ++CG+
Sbjct: 249 ACGGEHTVVLTEN-AVYTFGLGQFGQLGLGTFLFET-SEPKVIENIRD--QTISYISCGE 304
Query: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS--PTKLGGDLAGVNVIQVATYGDCCLA 297
+H+ +TD G +Y+ G G G+ GLG N T+ PT L ++++ G C +
Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLR--FIVKLVACGGCHMV 362
Query: 298 VSA 300
V A
Sbjct: 363 VFA 365
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 83.6 bits (205), Expect = 4e-16
Identities = 88/342 (25%), Positives = 146/342 (42%), Gaps = 72/342 (21%)
Query: 177 LQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVA 236
+ +SCG HS V+T ++ G+N++GQ G + S+ V ++ +V A
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAA 93
Query: 237 CGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCL 296
CG++H+L T+ G VY+ G +GQ GLG ++ + + + Q++ +
Sbjct: 94 CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSA 153
Query: 297 AVSADGGLFGWGNSEYLQL-----ASVTDSTQVNVPRCLHFSGVG--------------- 336
A++ DG LF WG++ Q+ ++V QV + + + + G
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213
Query: 337 ------------------------------KVRQAACGGTGCAVLNGEGHVFVWG---YG 363
KV Q ACGG VL E V+ +G +G
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272
Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
LG G L E++ P++I E + +S I CG +H A +T+ G ++ +G
Sbjct: 273 QLGLGTFLFETSEPKVI--------ENIRDQTISYISCGENHTALITDIGLMYTFGDGRH 324
Query: 424 GCLGIGRLEDQYFPWRVTMPGEPVD-----VACGVDHMVTLA 460
G LG+G LE+ + T+ + VACG HMV A
Sbjct: 325 GKLGLG-LENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365
Score = 80.5 bits (197), Expect = 3e-15
Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 22/240 (9%)
Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292
V ++CG +HS +T ++Y G GQ GLG + S PT + +++A G
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKA--LKPEKVKLAACG 95
Query: 293 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 349
VS +GG G N L L + +V F+ K++Q + G A
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153
Query: 350 VLNGEGHVFVWGYGILGKG--PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFA 407
L +G +F+WG G+ N+ VP+ + T P VS I CG H A
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203
Query: 408 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 464
+T GEL+V+G+ G LG+ L + P V+ +P + + VACG +H V L ++ +
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263
Score = 63.2 bits (152), Expect = 5e-10
Identities = 59/243 (24%), Positives = 109/243 (44%), Gaps = 39/243 (16%)
Query: 60 RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119
R+F+WG + G +G+ + VP ++ + + +S +CGY +
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVC-----------------VPQQVTIGKPVSWISCGYYHS 202
Query: 120 LLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQV 179
+ ++ + G ++ +LG R + V E +P +V+QV
Sbjct: 203 AFVTTDGEL---YVFGEPENGKLGLPNQLLGNHRTPQLVSE-----IP------EKVIQV 248
Query: 180 SCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
+CG H++VLT+ V++ G +GQ G E SE + ++D + ++CG+
Sbjct: 249 ACGGEHTVVLTEN-AVYTFGLGQFGQLGLGTFLFET-SEPKVIENIRD--QTISYISCGE 304
Query: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS--PTKLGGDLAGVNVIQVATYGDCCLA 297
+H+ +TD G +Y+ G G G+ GLG N T+ PT L ++++ G C +
Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLR--FIVKLVACGGCHMV 362
Query: 298 VSA 300
V A
Sbjct: 363 VFA 365
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 82.4 bits (202), Expect = 8e-16
Identities = 77/272 (28%), Positives = 124/272 (45%), Gaps = 43/272 (15%)
Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ---- 231
V+ SC AHSL++T ++S G N GQ G + ++ RV + +G
Sbjct: 153 VVSGSCA-AHSLLITTEGKLWSWGRNEKGQLG--------HGDTKRVEAPRLIEGLSHEV 203
Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVAT 290
+V ACG++H+L LT+ G V++ G GQ GLG+ + SP ++ + G + ++A
Sbjct: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261
Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN-----------VPR----CLHFSGV 335
+ + + G L+ +G EY QL +D + VPR + +
Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
Query: 336 GK--------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGL 387
G+ VR ACG VL+ + VF WG+G G+ L + + + P L L
Sbjct: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKL 378
Query: 388 TEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419
+F P S+I G + A++ G LF WG
Sbjct: 379 FDF-PGRGASQIYAGYTCSFAVSEVGGLFFWG 409
Score = 79.3 bits (194), Expect = 7e-15
Identities = 84/306 (27%), Positives = 126/306 (41%), Gaps = 52/306 (16%)
Query: 109 ISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPL 168
I SAACG TL ++T V+ G NK QLG G + PSP +
Sbjct: 204 IVSAACGRNHTLALTETG---SVFAFGENKMGQLGL---------GNQTDAVPSPAQIMY 251
Query: 169 DRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV------ 222
+ T+ ++CG S+++ + ++S G YGQ G + + + + R+
Sbjct: 252 NGQPITK---MACGAEFSMIMDCKGNLYSFGCPEYGQLGHN-SDGKFIARAQRIEYDCEL 307
Query: 223 --HRMQDF-----DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY 267
R+ F DGQ++ VACG +H+L L + V+S G+G G+ G
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
Query: 268 NITSSP--TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325
P KL D G Q+ C AVS GGLF WG A+ T
Sbjct: 368 KDEMVPRLVKL-FDFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTM 419
Query: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIP 381
P+ + ++R ACG + V E + WG +G LG G + +S+
Sbjct: 420 YPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEV 478
Query: 382 PTLFGL 387
TL G+
Sbjct: 479 KTLDGI 484
Score = 65.5 bits (158), Expect = 1e-10
Identities = 57/224 (25%), Positives = 98/224 (43%), Gaps = 21/224 (9%)
Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 291
VV +C HSL +T +G+++S G GQ G G +P + G L+ ++ A
Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210
Query: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 351
+ LA++ G +F +G ++ QL + V P + ++G + + ACG ++
Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269
Query: 352 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 393
+ +G+++ +G YG LG + LV V I T G P
Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
+ V + CG +H L ++ +F WG G LG +D+ P
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/217 (25%), Positives = 99/217 (45%), Gaps = 27/217 (12%)
Query: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRG----YEYVLEPS 162
Q I+ ACG F+++ ++ + G + QLG + K R Y+ L P
Sbjct: 254 QPITKMACGAEFSMIMDCKGNL---YSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPR 310
Query: 163 PVSLPLDRPQETRVL--------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE 214
V++ +++ ++ ++L V+CG H+LVL ++ VFS G YG+ G ++E
Sbjct: 311 RVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE 370
Query: 215 IYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 273
+ R+ ++ DF G+ Q+ G S +++ G ++ WGA + ++
Sbjct: 371 MVP---RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFF--WGATNTS-----RESTMY 420
Query: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310
K DL G + +A G + V+AD WG S
Sbjct: 421 PKAVQDLCGWRIRSLAC-GKSSIIVAADESTISWGPS 456
Score = 50.1 bits (118), Expect = 4e-06
Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)
Query: 278 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 334
G LAGV V V + G C L ++ +G L+ WG +E QL D+ +V PR +
Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200
Query: 335 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 393
+ AACG L G VF +G +G+ G AVP P + +N +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254
Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 440
++++ CG + KG L+ +G G LG I R + + P RV
Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313
Query: 441 -----TMPGE--PV------DVACGVDHMVTL 459
T G+ PV DVACG +H + L
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 82.4 bits (202), Expect = 8e-16
Identities = 77/272 (28%), Positives = 124/272 (45%), Gaps = 43/272 (15%)
Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ---- 231
V+ SC AHSL++T ++S G N GQ G + ++ RV + +G
Sbjct: 153 VVSGSCA-AHSLLITTEGKLWSWGRNEKGQLG--------HGDTKRVEAPRLIEGLSHEV 203
Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVAT 290
+V ACG++H+L LT+ G V++ G GQ GLG+ + SP ++ + G + ++A
Sbjct: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261
Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN-----------VPR----CLHFSGV 335
+ + + G L+ +G EY QL +D + VPR + +
Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
Query: 336 GK--------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGL 387
G+ VR ACG VL+ + VF WG+G G+ L + + + P L L
Sbjct: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKL 378
Query: 388 TEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419
+F P S+I G + A++ G LF WG
Sbjct: 379 FDF-PGRGASQIYAGYTCSFAVSEVGGLFFWG 409
Score = 79.3 bits (194), Expect = 7e-15
Identities = 84/306 (27%), Positives = 126/306 (41%), Gaps = 52/306 (16%)
Query: 109 ISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPL 168
I SAACG TL ++T V+ G NK QLG G + PSP +
Sbjct: 204 IVSAACGRNHTLALTETG---SVFAFGENKMGQLGL---------GNQTDAVPSPAQIMY 251
Query: 169 DRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV------ 222
+ T+ ++CG S+++ + ++S G YGQ G + + + + R+
Sbjct: 252 NGQPITK---MACGAEFSMIMDCKGNLYSFGCPEYGQLGHN-SDGKFIARAQRIEYDCEL 307
Query: 223 --HRMQDF-----DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY 267
R+ F DGQ++ VACG +H+L L + V+S G+G G+ G
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367
Query: 268 NITSSP--TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325
P KL D G Q+ C AVS GGLF WG A+ T
Sbjct: 368 KDEMVPRLVKL-FDFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTM 419
Query: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIP 381
P+ + ++R ACG + V E + WG +G LG G + +S+
Sbjct: 420 YPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEV 478
Query: 382 PTLFGL 387
TL G+
Sbjct: 479 KTLDGI 484
Score = 65.5 bits (158), Expect = 1e-10
Identities = 57/224 (25%), Positives = 98/224 (43%), Gaps = 21/224 (9%)
Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 291
VV +C HSL +T +G+++S G GQ G G +P + G L+ ++ A
Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210
Query: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 351
+ LA++ G +F +G ++ QL + V P + ++G + + ACG ++
Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269
Query: 352 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 393
+ +G+++ +G YG LG + LV V I T G P
Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
+ V + CG +H L ++ +F WG G LG +D+ P
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373
Score = 57.8 bits (138), Expect = 2e-08
Identities = 55/217 (25%), Positives = 99/217 (45%), Gaps = 27/217 (12%)
Query: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRG----YEYVLEPS 162
Q I+ ACG F+++ ++ + G + QLG + K R Y+ L P
Sbjct: 254 QPITKMACGAEFSMIMDCKGNL---YSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPR 310
Query: 163 PVSLPLDRPQETRVL--------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE 214
V++ +++ ++ ++L V+CG H+LVL ++ VFS G YG+ G ++E
Sbjct: 311 RVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE 370
Query: 215 IYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 273
+ R+ ++ DF G+ Q+ G S +++ G ++ WGA + ++
Sbjct: 371 MVP---RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFF--WGATNTS-----RESTMY 420
Query: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310
K DL G + +A G + V+AD WG S
Sbjct: 421 PKAVQDLCGWRIRSLAC-GKSSIIVAADESTISWGPS 456
Score = 50.1 bits (118), Expect = 4e-06
Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)
Query: 278 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 334
G LAGV V V + G C L ++ +G L+ WG +E QL D+ +V PR +
Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200
Query: 335 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 393
+ AACG L G VF +G +G+ G AVP P + +N +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254
Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 440
++++ CG + KG L+ +G G LG I R + + P RV
Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313
Query: 441 -----TMPGE--PV------DVACGVDHMVTL 459
T G+ PV DVACG +H + L
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 80.5 bits (197), Expect = 3e-15
Identities = 99/362 (27%), Positives = 145/362 (40%), Gaps = 63/362 (17%)
Query: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190
++ G N QLG E VL P ++ D + V +++ G HS V+T
Sbjct: 17 LFAWGANSYGQLGLGHK--------EDVLLPQQLN---DFCKPRSVRRITGGGGHSAVVT 65
Query: 191 DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGE 250
D +F G N GQ G E+ Y + F + QVACG D ++ LT+ G+
Sbjct: 66 DGGDLFVCGLNKDGQLGLGHTEDIPYFTPCK----SLFGCPIQQVACGWDFTIMLTENGQ 121
Query: 251 VYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310
V SCG + GQ G+ H +L V+ +A +A +A G +F WG
Sbjct: 122 VLSCGSNSFGQLGVPH-GPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG 180
Query: 311 EYLQLASVTDSTQVNVPRCLHFSGVGKVR-------QAAC---GGTGCAVLNGEGHVFVW 360
LAS L F+ R +A C G A L G V+VW
Sbjct: 181 ----LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVW 236
Query: 361 GYGILGKGPNLVESA---VPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFV 417
G G+ N E+A VP+ I F +V+ I G +H A T G++F
Sbjct: 237 GSNKHGQLAN--EAAFLPVPQKIEAHCF------QNEKVTAIWSGWTHLVAQTETGKMFT 288
Query: 418 WGKNIRGCLGIGRLEDQYFPWRV--------------TMPGEP------VDVACGVDHMV 457
WG+ G L GR + Y W++ +MP P +V+CG +H +
Sbjct: 289 WGRADYGQL--GRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNL 346
Query: 458 TL 459
+
Sbjct: 347 AI 348
Score = 74.7 bits (182), Expect = 2e-13
Identities = 97/374 (25%), Positives = 149/374 (39%), Gaps = 67/374 (17%)
Query: 122 SSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSC 181
S+ D ++ GLNKD QLG + E P P + QV+C
Sbjct: 61 SAVVTDGGDLFVCGLNKDGQLGLGHT------------EDIPYFTPCKSLFGCPIQQVAC 108
Query: 182 GRAHSLVLTDREGVFSMGNNSYGQCG------RKVVENEIYSESHRVHRMQDFDGQVVQV 235
G +++LT+ V S G+NS+GQ G R VV I E H+ +VV +
Sbjct: 109 GWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAI--ELHK--------EKVVCI 158
Query: 236 ACGQDHSLFLTDKGEVYSCGWG--------ADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 287
A G H++ T G V+ G G GQT L + P+++ G L +
Sbjct: 159 AAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQT-LPLFFTAKEPSRVTG-LENSKAMC 216
Query: 288 VATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--HFSGVGKVRQAACGG 345
V D +++ G ++ WG++++ QLA+ ++ + VP+ + H KV G
Sbjct: 217 VLAGSDHSASLTDAGEVYVWGSNKHGQLAN--EAAFLPVPQKIEAHCFQNEKVTAIWSGW 274
Query: 346 TGCAVLNGEGHVFVWG---YGILGKGPNLVE-------------SAVPEMIPPTLFGLTE 389
T G +F WG YG LG+ E S P +P + LT
Sbjct: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLT- 333
Query: 390 FNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--TMPGEPV 447
+ + CG H A+ G + WG N G G G + + P V + +
Sbjct: 334 -----GATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGL 387
Query: 448 DVACGVDHMVTLAK 461
V CG H + L +
Sbjct: 388 LVGCGAGHSLALCQ 401
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 71.2 bits (173), Expect = 2e-12
Identities = 60/271 (22%), Positives = 112/271 (41%), Gaps = 47/271 (17%)
Query: 60 RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119
+++ +G + G +GV P ++P+ L + +CG
Sbjct: 446 QLYAFGSDYYGCMGVDKVAGPEV-------------LEPMQLNFFLSNPVEQVSCGDNHV 492
Query: 120 LLSSKTADVTKVWGMG----LNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETR 175
++ ++ +V WG G L DS+ ++ +K +D P+
Sbjct: 493 VVLTRNKEVYS-WGCGEYGRLGLDSEEDYYTPQK------------------VDVPKALI 533
Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYG-----QCGRKVVENEIYSE-----SHRVHRM 225
++ V CG + +LT V + G N + QC ++ +E Y E S + +
Sbjct: 534 IVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQ 593
Query: 226 QDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNV 285
F ++ +A G+ H+ + ++G + + G GQ G+G+Y LGG L G V
Sbjct: 594 LSFY-KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQV 652
Query: 286 IQVATYGDCCLAVSADGGLFGWGNSEYLQLA 316
I+V+ + +A + D +F WGN +LA
Sbjct: 653 IRVSCGDEFTIAATDDNHIFAWGNGGNGRLA 683
Score = 67.0 bits (162), Expect = 3e-11
Identities = 70/276 (25%), Positives = 114/276 (41%), Gaps = 26/276 (9%)
Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227
+++ Q + QVSCG ++ +TD +++ G++ YG G V E +++
Sbjct: 420 VEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF-- 477
Query: 228 FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 287
V QV+CG +H + LT EVYS G G G+ GL +P K+ A + ++
Sbjct: 478 LSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI-IVA 536
Query: 288 VATYGDCCLAVSADGGLFGWGNSEYLQL-------ASVTDSTQVNVPRCLHFS-----GV 335
V D ++ G + G +E+ +L + VP F+
Sbjct: 537 VQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSF 596
Query: 336 GKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNP 392
K+R A G T A ++ G + +G G LG G N + ++ L G
Sbjct: 597 YKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG-NYKKRLGINLLGGPLGGK----- 650
Query: 393 EIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGI 428
QV R+ CG A T+ +F WG G L +
Sbjct: 651 --QVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684
Score = 65.9 bits (159), Expect = 8e-11
Identities = 58/202 (28%), Positives = 87/202 (43%), Gaps = 18/202 (8%)
Query: 271 SSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSE-----YLQLASVTDSTQVN 325
S+P KL +G + QV V+ + L+ W N + + QL D
Sbjct: 357 STPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYR 415
Query: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPP 382
P+ + +RQ +CG + EG ++ +G YG +G + + A PE++ P
Sbjct: 416 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMG----VDKVAGPEVLEP 471
Query: 383 TLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 442
NP QVS CG +H LT E++ WG G LG+ ED Y P +V +
Sbjct: 472 MQLNFFLSNPVEQVS---CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDV 528
Query: 443 PGEPVDVA--CGVDHMVTLAKS 462
P + VA CG D L +S
Sbjct: 529 PKALIIVAVQCGCDGTFLLTQS 550
Score = 62.4 bits (150), Expect = 8e-10
Identities = 74/274 (27%), Positives = 121/274 (44%), Gaps = 36/274 (13%)
Query: 178 QVSCGRAHSLVLTDREGVFSM-----GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQV 232
QV G H V+T + +++ G +GQ G + Y + V ++Q G+
Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHG--DKASYRQPKHVEKLQ---GKA 427
Query: 233 V-QVACGQDHSLFLTDKGEVYSCG---WGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288
+ QV+CG D ++ +TD+G++Y+ G +G G + + P +L L+ N ++
Sbjct: 428 IRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVL-EPMQLNFFLS--NPVEQ 484
Query: 289 ATYGDCCLAV-SADGGLFGWGNSEY--LQLASVTD---STQVNVPRCLHFSGVGKVRQAA 342
+ GD + V + + ++ WG EY L L S D +V+VP+ L V
Sbjct: 485 VSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAV------Q 538
Query: 343 CGGTGCAVLNGEGHVFVWGYGILGK-GPN------LVESAVPEMIPPTLFGLTEFNPEIQ 395
CG G +L G V G K G N + A E+ T F L + +
Sbjct: 539 CGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYK 598
Query: 396 VSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIG 429
+ I G +H AA+ +G L +G N G LG+G
Sbjct: 599 IRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG 632
Score = 46.2 bits (108), Expect = 6e-05
Identities = 49/214 (22%), Positives = 89/214 (41%), Gaps = 32/214 (14%)
Query: 57 RADRVFVWGFSFSGALGVPS---FVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAA 113
R V+ WG G LG+ S + P P+A I +
Sbjct: 497 RNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI------------------IVAVQ 538
Query: 114 CGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQE 173
CG T L +++ KV GLN+ ++LG ++ Y P S L +
Sbjct: 539 CGCDGTFLLTQSG---KVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLS 595
Query: 174 T-RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-- 230
++ ++ G+ H+ + +R + + G N GQ G V N Y + ++ + G
Sbjct: 596 FYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG---VGN--YKKRLGINLLGGPLGGK 650
Query: 231 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGL 264
QV++V+CG + ++ TD +++ G G +G+ +
Sbjct: 651 QVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 63.5 bits (153), Expect = 4e-10
Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 26/209 (12%)
Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD-GQVVQ 234
++QV+CG +H L L+ +F+ G G+ G ESH + GQ Q
Sbjct: 445 MVQVACGASHVLALSTERELFAWGRGDSGRLGLGT------RESHSCPQQVPMPPGQEAQ 498
Query: 235 -VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP------------TKLGG--- 278
V CG D S+ LT G+ +CG + GL H ++ P T LG
Sbjct: 499 RVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPL 558
Query: 279 DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 338
D + I + T AV+A G + +G++++ QL + T + G+ K+
Sbjct: 559 DQEPLLSIDLGTAHSA--AVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGI-KM 615
Query: 339 RQAACGGTGCAVLNGEGHVFVWGYGILGK 367
ACG + E V+ WG G G+
Sbjct: 616 AMVACGDAFTVAIGAESEVYSWGKGARGR 644
Score = 60.5 bits (145), Expect = 3e-09
Identities = 76/312 (24%), Positives = 126/312 (40%), Gaps = 35/312 (11%)
Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSES 219
+P +S L+ + V+CG + LTDR + + G+ S G G + + S+
Sbjct: 377 QPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTD--ISQP 434
Query: 220 HRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279
V + ++ +VQVACG H L L+ + E+++ G G G+ GLG S P ++
Sbjct: 435 TIVEALLGYE--MVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP 492
Query: 280 LAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA------SVTDSTQVNVPRCLHFS 333
G +V D + ++ G G++ + +L V L F+
Sbjct: 493 -PGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551
Query: 334 GVGK-------VRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPT 383
+G + G A + G + +G +G LG A P
Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-----PCK 606
Query: 384 LFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--- 440
+ GL I+++ + CG + A+ + E++ WGK RG LG R ED P V
Sbjct: 607 VQGL----EGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLG-RRDEDAGLPRPVQLD 661
Query: 441 -TMPGEPVDVAC 451
T P V+C
Sbjct: 662 ETHPYTVTSVSC 673
Score = 60.1 bits (144), Expect = 4e-09
Identities = 56/198 (28%), Positives = 80/198 (40%), Gaps = 22/198 (11%)
Query: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW-------GNSEYLQLASVTDSTQVNV 326
T L + V+QVA V+ G L W G L A Q +
Sbjct: 323 TPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQF-I 381
Query: 327 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG---ILGKGPNLVESAVPEMIPPT 383
R L ++ ACG A L G + +G G LG G +L + + P ++
Sbjct: 382 SRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHG-SLTDISQPTIVEAL 440
Query: 384 LFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMP 443
L ++ ++ CG SH AL+ + ELF WG+ G LG+G E P +V MP
Sbjct: 441 L--------GYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP 492
Query: 444 --GEPVDVACGVDHMVTL 459
E V CG+D + L
Sbjct: 493 PGQEAQRVVCGIDSSMIL 510
Score = 51.6 bits (122), Expect = 1e-06
Identities = 63/222 (28%), Positives = 94/222 (42%), Gaps = 29/222 (13%)
Query: 224 RMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGW-----GADGQTGLGHYNITSSPTKLGG 278
R+ + +VVQVA G+ +T G + W GA G + L P +
Sbjct: 326 RLPMLNTEVVQVAAGRTQKAGVTRSGRLIL--WEAPPLGAGGGSLLPGAVEQPQPQFISR 383
Query: 279 DL---AGVNVIQVATYGDCCLAVSADGGL---FGWGNSEYLQLASVTDSTQVNVPRCLHF 332
L +GV + VA GD A D G+ FG G++ L S+TD +Q + L
Sbjct: 384 FLEGQSGVTIKHVAC-GDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEAL-- 440
Query: 333 SGVG-KVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVES-AVPEMIPPTLFGLTE 389
+G ++ Q ACG + L+ E +F WG G G+ G ES + P+ +P
Sbjct: 441 --LGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVP-------- 490
Query: 390 FNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRL 431
P + R+ CG+ LT G+ G N LG+ L
Sbjct: 491 MPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHL 532
Score = 50.8 bits (120), Expect = 3e-06
Identities = 52/209 (24%), Positives = 88/209 (42%), Gaps = 32/209 (15%)
Query: 61 VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120
+F WG SG LG+ G R +++ P Q+ CG ++
Sbjct: 464 LFAWGRGDSGRLGL----------GTRESHSCPQQVPMPP-----GQEAQRVVCGIDSSM 508
Query: 121 LSSKTADVTKVWGMGLNKDSQLGF-HRSRKDKTRGYEYVLEPSPVSL----PLDRPQETR 175
+ + G N+ ++LG H S ++ ++ V E +L PLD+
Sbjct: 509 ILTVPGQAL---ACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP--- 562
Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQ 234
+L + G AHS +T ++ G+N +GQ G S ++Q +G ++
Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG-----SRAPCKVQGLEGIKMAM 617
Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTG 263
VACG ++ + + EVYS G GA G+ G
Sbjct: 618 VACGDAFTVAIGAESEVYSWGKGARGRLG 646
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 61.6 bits (148), Expect = 1e-09
Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 24/212 (11%)
Query: 157 YVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIY 216
YV +P PL E R Q+ G H+L+L VFS G +GQ G +E E+
Sbjct: 143 YVSPRAPFYRPL--APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199
Query: 217 SESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL 276
E + +Q + +VA G HS+ +++ G++Y GW GQ L N+
Sbjct: 200 -EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED---- 252
Query: 277 GGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGV 335
G V + AT + V GG + ++ + P L
Sbjct: 253 -----GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP--------FPALLDLPMG 299
Query: 336 GKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
+A+CG AV+ G ++ WG+G G+
Sbjct: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331
Score = 57.0 bits (136), Expect = 4e-08
Identities = 59/194 (30%), Positives = 79/194 (40%), Gaps = 22/194 (11%)
Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 293
Q+ G +H+L L G+V+S G G GQ G G P L L G+ + +VA G
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220
Query: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
+ VS G ++ WG +E QLA T R L G R+A LN
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265
Query: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413
+G G P + P P L L + ++ S CG H A +T G
Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319
Query: 414 ELFVWGKNIRGCLG 427
EL+ WG G LG
Sbjct: 320 ELYTWGWGKYGQLG 333
Score = 38.9 bits (89), Expect = 0.010
Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271
V+ +CG H+ +T GE+Y+ GWG GQ LGH + TS
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339
Score = 38.5 bits (88), Expect = 0.013
Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 163 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 222
P LD P + ++ SCG H+ V+T +++ G YGQ G + + RV
Sbjct: 289 PFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE--DTTSLDRPRRV 346
Query: 223 HRMQDFDGQVVQVACGQDHS-LFLTDKGE 250
D QV V CG ++ ++ +KG+
Sbjct: 347 EYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
Score = 34.3 bits (77), Expect = 0.25
Identities = 16/46 (34%), Positives = 23/46 (50%)
Query: 392 PEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
PE++ ++ G H L G++F WG G LG G LE + P
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 61.6 bits (148), Expect = 1e-09
Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 24/212 (11%)
Query: 157 YVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIY 216
YV +P PL E R Q+ G H+L+L VFS G +GQ G +E E+
Sbjct: 143 YVSPRAPFYRPL--APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199
Query: 217 SESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL 276
E + +Q + +VA G HS+ +++ G++Y GW GQ L N+
Sbjct: 200 -EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED---- 252
Query: 277 GGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGV 335
G V + AT + V GG + ++ + P L
Sbjct: 253 -----GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP--------FPALLDLPMG 299
Query: 336 GKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
+A+CG AV+ G ++ WG+G G+
Sbjct: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331
Score = 57.0 bits (136), Expect = 4e-08
Identities = 59/194 (30%), Positives = 79/194 (40%), Gaps = 22/194 (11%)
Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 293
Q+ G +H+L L G+V+S G G GQ G G P L L G+ + +VA G
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220
Query: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
+ VS G ++ WG +E QLA T R L G R+A LN
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265
Query: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413
+G G P + P P L L + ++ S CG H A +T G
Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319
Query: 414 ELFVWGKNIRGCLG 427
EL+ WG G LG
Sbjct: 320 ELYTWGWGKYGQLG 333
Score = 38.9 bits (89), Expect = 0.010
Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)
Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271
V+ +CG H+ +T GE+Y+ GWG GQ LGH + TS
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339
Score = 38.5 bits (88), Expect = 0.013
Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 3/89 (3%)
Query: 163 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 222
P LD P + ++ SCG H+ V+T +++ G YGQ G + + RV
Sbjct: 289 PFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE--DTTSLDRPRRV 346
Query: 223 HRMQDFDGQVVQVACGQDHS-LFLTDKGE 250
D QV V CG ++ ++ +KG+
Sbjct: 347 EYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375
Score = 34.3 bits (77), Expect = 0.25
Identities = 16/46 (34%), Positives = 23/46 (50%)
Query: 392 PEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
PE++ ++ G H L G++F WG G LG G LE + P
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201
>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
Length = 1353
Score = 58.5 bits (140), Expect = 1e-08
Identities = 47/171 (27%), Positives = 76/171 (44%), Gaps = 10/171 (5%)
Query: 190 TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKG 249
TD V++ G+N+ G ++ + E + + QV + HS+FL+ KG
Sbjct: 139 TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGI--YIKQVVLCKFHSVFLSQKG 196
Query: 250 EVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGN 309
+VY+CG G G+ G G P + G L G N QVA D + ++ DG ++ +G
Sbjct: 197 QVYTCGHGPGGRLGHGDEQTCLVPRLVEG-LNGHNCSQVAAAKDHTVVLTEDGCVYTFGL 255
Query: 310 SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360
+ + QL + + NVPR + + G T V G H +W
Sbjct: 256 NIFHQLGIIPPPSSCNVPRQIQ-------AKYLKGRTIIGVAAGRFHTVLW 299
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 53.9 bits (128), Expect = 3e-07
Identities = 53/194 (27%), Positives = 80/194 (41%), Gaps = 30/194 (15%)
Query: 195 VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYS 253
VFS G+ +G+ GR E + ++ +GQ V Q+ CG L LT G V++
Sbjct: 25 VFSWGDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 79
Query: 254 CGWGADGQTGLGHYNITS--SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSE 311
WG LGH + P + G L G ++ VA CLAV G ++ WG+++
Sbjct: 80 --WGKGDYFRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 136
Query: 312 YLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNL 371
+ Q + T +T P + K+ ACG + H W
Sbjct: 137 HGQQGNGT-TTVNRKPTLVQGLEGQKIMCVACGSS---------HSVAW---------TT 177
Query: 372 VESAVPEMIPPTLF 385
V+ A P + P LF
Sbjct: 178 VDVATPSVHEPVLF 191
Score = 50.4 bits (119), Expect = 3e-06
Identities = 39/126 (30%), Positives = 58/126 (46%), Gaps = 13/126 (10%)
Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227
++R V Q+ CG L LT V++ G Y + G + S+ H V + Q
Sbjct: 50 IERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHR-------SDVH-VRKPQV 101
Query: 228 FDG----QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283
+G ++V VA G H L + D G+VY+ G GQ G G + PT + G L G
Sbjct: 102 VEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG-LEGQ 160
Query: 284 NVIQVA 289
++ VA
Sbjct: 161 KIMCVA 166
Score = 43.5 bits (101), Expect = 4e-04
Identities = 41/156 (26%), Positives = 64/156 (41%), Gaps = 9/156 (5%)
Query: 304 LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG 363
+F WG+ ++ +L S N+P+ + V Q CG L G V+ WG G
Sbjct: 25 VFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
+ + S V P + GL ++ + G H A+ + G+++ WG N
Sbjct: 84 DYFRLGH--RSDVHVRKPQVVEGLRGK----KIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137
Query: 424 GCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 457
G G G P V + G+ + VACG H V
Sbjct: 138 GQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSV 173
Score = 29.6 bits (65), Expect = 6.1
Identities = 24/68 (35%), Positives = 28/68 (41%), Gaps = 8/68 (11%)
Query: 354 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412
E VF WG G GK G E IP + L V +I CG ALT
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 74
Query: 413 GELFVWGK 420
G ++ WGK
Sbjct: 75 GVVWTWGK 82
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 52.8 bits (125), Expect = 7e-07
Identities = 50/193 (25%), Positives = 80/193 (41%), Gaps = 28/193 (14%)
Query: 195 VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYS 253
VFS G+ +G+ GR E + ++ +GQ V Q+ CG L LT G V++
Sbjct: 727 VFSWGDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 781
Query: 254 CGWGADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEY 312
WG LGH + + ++ L G ++ VA CLAV G ++ WG++++
Sbjct: 782 --WGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 839
Query: 313 LQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLV 372
Q + T +T P + K+ ACG + H W +
Sbjct: 840 GQQGNGT-TTVNRKPMLVQGLEGQKIMCVACGSS---------HSVAW---------TTM 880
Query: 373 ESAVPEMIPPTLF 385
+ A P + P LF
Sbjct: 881 DVATPSVHEPVLF 893
Score = 49.7 bits (117), Expect = 6e-06
Identities = 38/126 (30%), Positives = 58/126 (46%), Gaps = 13/126 (10%)
Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227
++R V Q+ CG L LT V++ G Y + G + S+ H V ++Q
Sbjct: 752 IERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHR-------SDVH-VRKLQV 803
Query: 228 FDG----QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283
+G ++V VA G H L + D G+VY+ G GQ G G + P + G L G
Sbjct: 804 VEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQG-LEGQ 862
Query: 284 NVIQVA 289
++ VA
Sbjct: 863 KIMCVA 868
Score = 43.1 bits (100), Expect = 5e-04
Identities = 41/159 (25%), Positives = 66/159 (41%), Gaps = 10/159 (6%)
Query: 302 GGL-FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360
GGL F WG+ ++ +L S N+P+ + V Q CG L G V+ W
Sbjct: 724 GGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 782
Query: 361 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK 420
G G + + + V ++ + E ++ + G H A+ + G+++ WG
Sbjct: 783 GKGDYFRLGHRSDVHVRKL------QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGD 836
Query: 421 NIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 457
N G G G P V + G+ + VACG H V
Sbjct: 837 NDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSV 875
Score = 30.4 bits (67), Expect = 3.6
Identities = 50/188 (26%), Positives = 64/188 (34%), Gaps = 30/188 (15%)
Query: 247 DKGEVYSCGWGADGQTGLGHYN--------ITSSPTKLGGDLAGV--NVIQVATYGDCC- 295
D+GE + G ADG +YN +P G A + +GD C
Sbjct: 613 DEGE--AAGAAADGVAAYSNYNNGHRKFLATAQNPADEPGPGAPAPQELGAAGKHGDLCE 670
Query: 296 --LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
L SA G W + + V + GKV T C +
Sbjct: 671 VSLTSSAQGEAT-WPHPVLFHFGEIIQDKSVGN---WEYISTGKVSDNYALLTKCEM--- 723
Query: 354 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412
G VF WG G GK G E IP + L V +I CG ALT
Sbjct: 724 GGLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 776
Query: 413 GELFVWGK 420
G ++ WGK
Sbjct: 777 GVVWTWGK 784
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.138 0.432
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,802,236
Number of Sequences: 37866
Number of extensions: 897931
Number of successful extensions: 3050
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2450
Number of HSP's gapped (non-prelim): 189
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.