Guide to the Human Genome
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Search of human proteins with 13540582

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
         (464 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ...   954   0.0  
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo...   561   e-160
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo...   561   e-160
gi|7657152 hect domain and RLD 3 [Homo sapiens]                       122   5e-28
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]            120   2e-27
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]            120   2e-27
gi|61563742 hect domain and RLD 6 [Homo sapiens]                      105   9e-23
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]   102   7e-22
gi|4557445 regulator of chromosome condensation and BTB domain c...   100   2e-21
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ...    93   6e-19
gi|126032348 hect domain and RLD 2 [Homo sapiens]                      90   4e-18
gi|110825982 hect domain and RLD 5 [Homo sapiens]                      90   5e-18
gi|114796646 regulator of chromosome condensation 1 isoform b [H...    87   2e-17
gi|114796644 regulator of chromosome condensation 1 isoform a [H...    87   2e-17
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom...    87   2e-17
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]     87   2e-17
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]     87   2e-17
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]     87   2e-17
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo...    84   4e-16
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    84   4e-16
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]     82   8e-16
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]      82   8e-16
gi|6912330 deafness locus associated putative guanine nucleotide...    80   3e-15
gi|222136641 NIMA-related kinase 9 [Homo sapiens]                      71   2e-12
gi|30039692 NIMA-related kinase 8 [Homo sapiens]                       64   4e-10
gi|63054860 RCC1 domain containing 1 [Homo sapiens]                    62   1e-09
gi|63054858 RCC1 domain containing 1 [Homo sapiens]                    62   1e-09
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]       59   1e-08
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ...    54   3e-07
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s...    53   7e-07

>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
           sapiens]
          Length = 464

 Score =  954 bits (2466), Expect = 0.0
 Identities = 464/464 (100%), Positives = 464/464 (100%)

Query: 1   MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADR 60
           MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADR
Sbjct: 1   MALVALVAGARLGRRLSGPGLGRGHWTAARRSRSRREAAEAEAEVPVVQYVGERAARADR 60

Query: 61  VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120
           VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL
Sbjct: 61  VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120

Query: 121 LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS 180
           LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS
Sbjct: 121 LSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVS 180

Query: 181 CGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQD 240
           CGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQD
Sbjct: 181 CGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQD 240

Query: 241 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 300
           HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA
Sbjct: 241 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 300

Query: 301 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360
           DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW
Sbjct: 301 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360

Query: 361 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK 420
           GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK
Sbjct: 361 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK 420

Query: 421 NIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI 464
           NIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 421 NIRGCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAKSFI 464


>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
           sapiens]
          Length = 267

 Score =  561 bits (1445), Expect = e-160
 Identities = 266/267 (99%), Positives = 266/267 (99%)

Query: 198 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 257
           MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 1   MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60

Query: 258 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 317
           ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120

Query: 318 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 377
           VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180

Query: 378 EMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
           EMIPPTLFGLTEFNPEIQVSRIRCGLS FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240

Query: 438 WRVTMPGEPVDVACGVDHMVTLAKSFI 464
           WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 63/206 (30%), Positives = 93/206 (45%), Gaps = 26/206 (12%)

Query: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVV 233
           +V+QV+CG+ HSL LTD+  V+S G  + GQ G  +    I S   ++    D  G  V+
Sbjct: 34  QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTG--LGHYNITSSPTKLG--GDLAGVNVI 89

Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS-----PTKLGGDLAGVNVIQV 288
           QVA   D  L ++  G ++  GWG      L   ++T S     P  L     G  V Q 
Sbjct: 90  QVATYGDCCLAVSADGGLF--GWGNSEYLQLA--SVTDSTQVNVPRCLHFSGVG-KVRQA 144

Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--------HFSGVGKVRQ 340
           A  G  C  ++ +G +F WG   Y  L    +  +  VP  +         F+   +V +
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201

Query: 341 AACGGTGCAVLNGEGHVFVWGYGILG 366
             CG +  A L  +G +FVWG  I G
Sbjct: 202 IRCGLSRFAALTNKGELFVWGKNIRG 227



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 19/140 (13%)

Query: 108 KISSAACG-YGFTLLSSKTADVTKVWGMG-LNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165
           K+  AACG  G  +L+ +      VWG G L K   L               ++ P+   
Sbjct: 140 KVRQAACGGTGCAVLNGEGH--VFVWGYGILGKGPNL--------VESAVPEMIPPTLFG 189

Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225
           L    P E +V ++ CG +    LT++  +F  G N  G  G   +E++ +    RV   
Sbjct: 190 LTEFNP-EIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF--PWRV--- 243

Query: 226 QDFDGQVVQVACGQDHSLFL 245
               G+ V VACG DH + L
Sbjct: 244 -TMPGEPVDVACGVDHMVTL 262


>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
           sapiens]
          Length = 267

 Score =  561 bits (1445), Expect = e-160
 Identities = 266/267 (99%), Positives = 266/267 (99%)

Query: 198 MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 257
           MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG
Sbjct: 1   MGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWG 60

Query: 258 ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 317
           ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS
Sbjct: 61  ADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLAS 120

Query: 318 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 377
           VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP
Sbjct: 121 VTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVP 180

Query: 378 EMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
           EMIPPTLFGLTEFNPEIQVSRIRCGLS FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP
Sbjct: 181 EMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 240

Query: 438 WRVTMPGEPVDVACGVDHMVTLAKSFI 464
           WRVTMPGEPVDVACGVDHMVTLAKSFI
Sbjct: 241 WRVTMPGEPVDVACGVDHMVTLAKSFI 267



 Score = 58.9 bits (141), Expect = 9e-09
 Identities = 63/206 (30%), Positives = 93/206 (45%), Gaps = 26/206 (12%)

Query: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVV 233
           +V+QV+CG+ HSL LTD+  V+S G  + GQ G  +    I S   ++    D  G  V+
Sbjct: 34  QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTG--LGHYNITSSPTKLG--GDLAGVNVI 89

Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS-----PTKLGGDLAGVNVIQV 288
           QVA   D  L ++  G ++  GWG      L   ++T S     P  L     G  V Q 
Sbjct: 90  QVATYGDCCLAVSADGGLF--GWGNSEYLQLA--SVTDSTQVNVPRCLHFSGVG-KVRQA 144

Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--------HFSGVGKVRQ 340
           A  G  C  ++ +G +F WG   Y  L    +  +  VP  +         F+   +V +
Sbjct: 145 ACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 201

Query: 341 AACGGTGCAVLNGEGHVFVWGYGILG 366
             CG +  A L  +G +FVWG  I G
Sbjct: 202 IRCGLSRFAALTNKGELFVWGKNIRG 227



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 40/140 (28%), Positives = 60/140 (42%), Gaps = 19/140 (13%)

Query: 108 KISSAACG-YGFTLLSSKTADVTKVWGMG-LNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165
           K+  AACG  G  +L+ +      VWG G L K   L               ++ P+   
Sbjct: 140 KVRQAACGGTGCAVLNGEGH--VFVWGYGILGKGPNL--------VESAVPEMIPPTLFG 189

Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225
           L    P E +V ++ CG +    LT++  +F  G N  G  G   +E++ +    RV   
Sbjct: 190 LTEFNP-EIQVSRIRCGLSRFAALTNKGELFVWGKNIRGCLGIGRLEDQYF--PWRV--- 243

Query: 226 QDFDGQVVQVACGQDHSLFL 245
               G+ V VACG DH + L
Sbjct: 244 -TMPGEPVDVACGVDHMVTL 262


>gi|7657152 hect domain and RLD 3 [Homo sapiens]
          Length = 1050

 Score =  122 bits (307), Expect = 5e-28
 Identities = 83/239 (34%), Positives = 118/239 (49%), Gaps = 16/239 (6%)

Query: 229 DGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288
           D  V +VACG +HS+FL + GEVY+CG    GQ  LGH    + P ++G  LA  ++I V
Sbjct: 33  DRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQ--LGHEREGNKPEQIGA-LADQHIIHV 89

Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGC 348
           A      LA+S  G LF WG     QL  +T    V VPR +       + Q +CG   C
Sbjct: 90  ACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHC 149

Query: 349 AVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSH 405
             L  +G  F WG   +G LG G      A P+ +  +L G       I ++++  G +H
Sbjct: 150 LALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRV-RSLEG-------IPLAQVAAGGAH 201

Query: 406 FAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM--PGEPVDVACGVDHMVTLAKS 462
             AL+  G +F WG N  G LG+   +D+  P  V +    + V ++CG +H   L KS
Sbjct: 202 SFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKS 260



 Score =  112 bits (281), Expect = 5e-25
 Identities = 98/328 (29%), Positives = 152/328 (46%), Gaps = 34/328 (10%)

Query: 106 DQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165
           D+ +   ACG   ++   +  +V   +  GLN   QLG  R             +P  + 
Sbjct: 33  DRSVKEVACGGNHSVFLLEDGEV---YTCGLNTKGQLGHEREGN----------KPEQIG 79

Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRM 225
              D+     ++ V+CG +HSL L+DR  +FS G  S GQ G    E+ +      V R+
Sbjct: 80  ALADQ----HIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSV-----AVPRL 130

Query: 226 -QDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLG-HYNITSSPTKLGGDLAG 282
            Q  + Q ++QV+CG  H L L   G+ ++ G  + GQ GLG  +   +SP ++   L G
Sbjct: 131 IQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRV-RSLEG 189

Query: 283 VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342
           + + QVA  G    A+S  G +FGWG +   QL  ++D      P  +      KV   +
Sbjct: 190 IPLAQVAAGGAHSFALSLSGAVFGWGMNNAGQL-GLSDEKDRESPCHVKLLRTQKVVYIS 248

Query: 343 CGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 402
           CG    AVL   G VF +G G  G+  +  +S   E+ P  +  L       +V++I CG
Sbjct: 249 CGEEHTAVLTKSGGVFTFGAGSCGQLGH--DSMNDEVNPRRVLELM----GSEVTQIACG 302

Query: 403 LSH-FAALTNKGELFVWGKNIRGCLGIG 429
             H  A + + G ++ +G   RG LG G
Sbjct: 303 RQHTLAFVPSSGLIYAFGCGARGQLGTG 330



 Score = 80.9 bits (198), Expect = 2e-15
 Identities = 68/218 (31%), Positives = 100/218 (45%), Gaps = 34/218 (15%)

Query: 62  FVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLL 121
           F WG +  G LG+     PS     R      R ++ +P    L Q  +  A  +  +L 
Sbjct: 159 FTWGKNSHGQLGLGK-EFPSQASPQRV-----RSLEGIP----LAQVAAGGAHSFALSLS 208

Query: 122 SSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSC 181
            +       V+G G+N   QLG     KD+          SP  + L R Q  +V+ +SC
Sbjct: 209 GA-------VFGWGMNNAGQLGLS-DEKDRE---------SPCHVKLLRTQ--KVVYISC 249

Query: 182 GRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDH 241
           G  H+ VLT   GVF+ G  S GQ G   + +E+     RV  ++    +V Q+ACG+ H
Sbjct: 250 GEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEV--NPRRV--LELMGSEVTQIACGRQH 305

Query: 242 SL-FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGG 278
           +L F+   G +Y+ G GA GQ G GH      P+ + G
Sbjct: 306 TLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKG 343



 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 39/137 (28%), Positives = 58/137 (42%), Gaps = 11/137 (8%)

Query: 327 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFG 386
           P+   F     V++ ACGG     L  +G V+  G    G+  +  E   PE I      
Sbjct: 25  PQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGAL--- 81

Query: 387 LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEP 446
                 +  +  + CG SH  AL+++G+LF WG    G LG+   ED     R+      
Sbjct: 82  -----ADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQ 136

Query: 447 ---VDVACGVDHMVTLA 460
              + V+CG  H + LA
Sbjct: 137 QTILQVSCGNWHCLALA 153



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 32/111 (28%), Positives = 47/111 (42%), Gaps = 24/111 (21%)

Query: 360 WGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419
           WGY  LG+ P +  +    +  P + G   F  +  V  + CG +H   L   GE++  G
Sbjct: 4   WGYWSLGQ-PGISTNLQGIVAEPQVCG---FISDRSVKEVACGGNHSVFLLEDGEVYTCG 59

Query: 420 KNIRGCLG----------IGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLA 460
            N +G LG          IG L DQ+           + VACG  H + L+
Sbjct: 60  LNTKGQLGHEREGNKPEQIGALADQHI----------IHVACGESHSLALS 100


>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
          Length = 1049

 Score =  120 bits (302), Expect = 2e-27
 Identities = 106/348 (30%), Positives = 154/348 (44%), Gaps = 28/348 (8%)

Query: 105 LDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPV 164
           +++++    CG   T+      D   V+  G N   QLG  +SRK          +P  V
Sbjct: 32  INKRVRDVGCGLRHTVF---VLDDGTVYTCGCNDLGQLGHEKSRK----------KPEQV 78

Query: 165 SLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHR 224
            + LD      ++ VSCG AH+L L D+  V++ G +S GQ G  V   E       +  
Sbjct: 79  -VALDAQN---IVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL-VGSEECIRVPRNIKS 133

Query: 225 MQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284
           + D   Q+VQVACG  HSL L+   EV+  G    GQ GLG      +  +L   L G+ 
Sbjct: 134 LSDI--QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIP 191

Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
            +QVA  G     ++  G +FGWG +++ QL  + D     VP  L      K+    CG
Sbjct: 192 FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GLNDENDRYVPNLLKSLRSQKIVYICCG 250

Query: 345 GTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLS 404
               A L  EG VF +G G  G G     S   E+ P  +F L        V+ I CG  
Sbjct: 251 EDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHEINPRKVFELM----GSIVTEIACGRQ 304

Query: 405 HFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVAC 451
           H +A + + G ++ +G    G LG G   ++  P+ V     P +  C
Sbjct: 305 HTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQC 352



 Score =  108 bits (269), Expect = 1e-23
 Identities = 86/270 (31%), Positives = 126/270 (46%), Gaps = 22/270 (8%)

Query: 199 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 256
           GN S+GQ G   ++ EI  E     R  DF  + +V  V CG  H++F+ D G VY+CG 
Sbjct: 5   GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 257 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 316
              GQ  LGH      P ++   L   N++ V+      LA++  G ++ WG     QL 
Sbjct: 61  NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117

Query: 317 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 373
            V     + VPR +      ++ Q ACG      L+    VF WG   YG LG G +  +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177

Query: 374 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLED 433
              P+++  +L G+    P +QV+    G +H   LT  G +F WG+N  G LG+    D
Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229

Query: 434 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 461
           +Y P   +     + V + CG DH   L K
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 40/228 (17%)

Query: 56  ARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACG 115
           ++A  VF WG +  G LG+ +     + P      +  + +  +P+     Q  +  A  
Sbjct: 153 SKASEVFCWGQNKYGQLGLGTDCKKQTSP------QLLKSLLGIPFM----QVAAGGAHS 202

Query: 116 YGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETR 175
           +  TL  +       ++G G NK  QLG +    D+   Y        V   L   +  +
Sbjct: 203 FVLTLSGA-------IFGWGRNKFGQLGLN----DENDRY--------VPNLLKSLRSQK 243

Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD--GQVV 233
           ++ + CG  H+  LT   GVF+ G   YGQ G         S SH ++  + F+  G +V
Sbjct: 244 IVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN-------STSHEINPRKVFELMGSIV 296

Query: 234 -QVACGQDH-SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279
            ++ACG+ H S F+   G +YS G G +GQ G G  +   SP  + G+
Sbjct: 297 TEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGN 344


>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
          Length = 1057

 Score =  120 bits (302), Expect = 2e-27
 Identities = 106/348 (30%), Positives = 154/348 (44%), Gaps = 28/348 (8%)

Query: 105 LDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPV 164
           +++++    CG   T+      D   V+  G N   QLG  +SRK          +P  V
Sbjct: 32  INKRVRDVGCGLRHTVF---VLDDGTVYTCGCNDLGQLGHEKSRK----------KPEQV 78

Query: 165 SLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHR 224
            + LD      ++ VSCG AH+L L D+  V++ G +S GQ G  V   E       +  
Sbjct: 79  -VALDAQN---IVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGL-VGSEECIRVPRNIKS 133

Query: 225 MQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284
           + D   Q+VQVACG  HSL L+   EV+  G    GQ GLG      +  +L   L G+ 
Sbjct: 134 LSDI--QIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIP 191

Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
            +QVA  G     ++  G +FGWG +++ QL  + D     VP  L      K+    CG
Sbjct: 192 FMQVAAGGAHSFVLTLSGAIFGWGRNKFGQL-GLNDENDRYVPNLLKSLRSQKIVYICCG 250

Query: 345 GTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLS 404
               A L  EG VF +G G  G G     S   E+ P  +F L        V+ I CG  
Sbjct: 251 EDHTAALTKEGGVFTFGAG--GYGQLGHNSTSHEINPRKVFELM----GSIVTEIACGRQ 304

Query: 405 HFAA-LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPVDVAC 451
           H +A + + G ++ +G    G LG G   ++  P+ V     P +  C
Sbjct: 305 HTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQC 352



 Score =  108 bits (269), Expect = 1e-23
 Identities = 86/270 (31%), Positives = 126/270 (46%), Gaps = 22/270 (8%)

Query: 199 GNNSYGQCGRKVVENEIYSESHRVHRMQDF--DGQVVQVACGQDHSLFLTDKGEVYSCGW 256
           GN S+GQ G   ++ EI  E     R  DF  + +V  V CG  H++F+ D G VY+CG 
Sbjct: 5   GNASFGQLGLGGIDEEIVLEP----RKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGC 60

Query: 257 GADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA 316
              GQ  LGH      P ++   L   N++ V+      LA++  G ++ WG     QL 
Sbjct: 61  NDLGQ--LGHEKSRKKPEQVVA-LDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117

Query: 317 SVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVE 373
            V     + VPR +      ++ Q ACG      L+    VF WG   YG LG G +  +
Sbjct: 118 LVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKK 177

Query: 374 SAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLED 433
              P+++  +L G+    P +QV+    G +H   LT  G +F WG+N  G LG+    D
Sbjct: 178 QTSPQLL-KSLLGI----PFMQVA---AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDEND 229

Query: 434 QYFP--WRVTMPGEPVDVACGVDHMVTLAK 461
           +Y P   +     + V + CG DH   L K
Sbjct: 230 RYVPNLLKSLRSQKIVYICCGEDHTAALTK 259



 Score = 73.2 bits (178), Expect = 5e-13
 Identities = 62/228 (27%), Positives = 101/228 (44%), Gaps = 40/228 (17%)

Query: 56  ARADRVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACG 115
           ++A  VF WG +  G LG+ +     + P      +  + +  +P+     Q  +  A  
Sbjct: 153 SKASEVFCWGQNKYGQLGLGTDCKKQTSP------QLLKSLLGIPFM----QVAAGGAHS 202

Query: 116 YGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETR 175
           +  TL  +       ++G G NK  QLG +    D+   Y        V   L   +  +
Sbjct: 203 FVLTLSGA-------IFGWGRNKFGQLGLN----DENDRY--------VPNLLKSLRSQK 243

Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD--GQVV 233
           ++ + CG  H+  LT   GVF+ G   YGQ G         S SH ++  + F+  G +V
Sbjct: 244 IVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHN-------STSHEINPRKVFELMGSIV 296

Query: 234 -QVACGQDH-SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279
            ++ACG+ H S F+   G +YS G G +GQ G G  +   SP  + G+
Sbjct: 297 TEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGN 344


>gi|61563742 hect domain and RLD 6 [Homo sapiens]
          Length = 1022

 Score =  105 bits (262), Expect = 9e-23
 Identities = 85/283 (30%), Positives = 130/283 (45%), Gaps = 12/283 (4%)

Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ- 234
           +LQ + G  HSL+L     V S G+NS GQ GR+  +     E      +Q  +  +V  
Sbjct: 25  LLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEP-----IQALETLIVDL 79

Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294
           V+CG++HSL +  KG V++ G G++GQ G+G +   S   K    L  + +IQV+     
Sbjct: 80  VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139

Query: 295 CLAVSADGGLFGWGNSEYLQLASVTD-STQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
            LA+S D  +F WG + + QL    +  +Q +  R     G+  + Q A GG     L+ 
Sbjct: 140 SLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGI-PLAQVAAGGAHSFALSL 198

Query: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413
            G  F WG    G+      +   +   P   G  +    + V  I CG +H A LT  G
Sbjct: 199 CGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALK---NLGVVYISCGDAHTAVLTQDG 255

Query: 414 ELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVDVACGVDH 455
           ++F +G N  G LG     ++  P  V  + G    + CG  H
Sbjct: 256 KVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCGSYH 298



 Score = 63.9 bits (154), Expect = 3e-10
 Identities = 94/348 (27%), Positives = 143/348 (41%), Gaps = 47/348 (13%)

Query: 26  WTAARRSRSRREAAEAEAEVPVVQYVGERAARA----DRVFVWGFSFSGALGVPSFVVPS 81
           W A  R   RR  A +     +    GER +       RV   G +  G LG        
Sbjct: 5   WGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLG-------- 56

Query: 82  SGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQ 141
                R GA+  R   P P +      +   +CG   +L       V   WG G   + Q
Sbjct: 57  -----RRGAQ--RGELPEPIQALETLIVDLVSCGKEHSLAVCHKGRVF-AWGAG--SEGQ 106

Query: 142 LGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNN 201
           LG    +       E    P  +    D     +++QVSCG  HSL L+    VFS G N
Sbjct: 107 LGIGEFK-------EISFTPKKIMTLND----IKIIQVSCGHYHSLALSKDSQVFSWGKN 155

Query: 202 SYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADG 260
           S+GQ G   +  E  S++    R++  +G  + QVA G  HS  L+  G  +  G  + G
Sbjct: 156 SHGQLG---LGKEFPSQA-SPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAG 211

Query: 261 QTGLGHYNI---TSSPTKLGGDLAGVNVIQVATYGDCCLAV-SADGGLFGWGNSEYLQLA 316
           Q  L   N+   ++ P  +G  L  + V+ ++  GD   AV + DG +F +G++   QL 
Sbjct: 212 QLALSGRNVPVQSNKPLSVGA-LKNLGVVYISC-GDAHTAVLTQDGKVFTFGDNRSGQL- 268

Query: 317 SVTDSTQVNVPRCLHFSGVGKVRQAACGG-TGCAVLNGEGHVFVWGYG 363
             + + +   P+ +     G V Q  CG     A ++  G V  +G+G
Sbjct: 269 GYSPTPEKRGPQLVERID-GLVSQIDCGSYHTLAYVHTTGQVVSFGHG 315


>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
          Length = 4861

 Score =  102 bits (254), Expect = 7e-22
 Identities = 81/273 (29%), Positives = 132/273 (48%), Gaps = 26/273 (9%)

Query: 177  LQVSCGR-AHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQ 234
            L  SCG   HS+ LT+   VFS G+  YG+ G    + +      R  +++   G+ VVQ
Sbjct: 4084 LVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQ-----RRPRQIEALQGEEVVQ 4138

Query: 235  VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294
            ++CG  HS  +T  G++++ G G  G+ GLG+ +    P ++   L G  + QVA   + 
Sbjct: 4139 MSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTA-LEGYQIGQVACGLNH 4197

Query: 295  CLAVSADGGL-FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
             LAVSADG + + +G+ +Y +L     + + +  +     G+G +++ ACG      L  
Sbjct: 4198 TLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIG-IKKVACGTQFSVALTK 4256

Query: 354  EGHVFVWGYGIL-----GKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAA 408
            +GHV+ +G   L     G+  N      P+ IP  L G+        +  +  G  H  A
Sbjct: 4257 DGHVYTFGQDRLIGLPEGRARNHNR---PQQIP-VLAGVI-------IEDVAVGAEHTLA 4305

Query: 409  LTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT 441
            L + G+++ WG N  G LG+G       P  VT
Sbjct: 4306 LASNGDVYAWGSNSEGQLGLGHTNHVREPTLVT 4338



 Score = 94.7 bits (234), Expect = 2e-19
 Identities = 85/307 (27%), Positives = 143/307 (46%), Gaps = 22/307 (7%)

Query: 164  VSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVH 223
            V +P   P  ++  QV CG+  + V+     V + G  SYG+ G+    ++       + 
Sbjct: 4017 VMVPAAAPSFSQAQQVICGQNCTFVIQANGTVLACGEGSYGRLGQG--NSDDLHVLTVIS 4074

Query: 224  RMQDFDGQVVQVACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAG 282
             +Q F    +  +CG D HS+ LT+ GEV+S G G  G+ G G+ +    P ++   L G
Sbjct: 4075 ALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEA-LQG 4133

Query: 283  VNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAA 342
              V+Q++        V++DG LF +GN +Y +L     S +    R     G  ++ Q A
Sbjct: 4134 EEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGY-QIGQVA 4192

Query: 343  CGGTGCAVLNGEGHVFVWG-----YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVS 397
            CG      ++ +G + VW      YG LG G +  +S+ P+ I   L G       I + 
Sbjct: 4193 CGLNHTLAVSADGSM-VWAFGDGDYGKLGLGNSTAKSS-PQKI-DVLCG-------IGIK 4242

Query: 398  RIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV--DVACGVDH 455
            ++ CG     ALT  G ++ +G++    L  GR  +   P ++ +    +  DVA G +H
Sbjct: 4243 KVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEH 4302

Query: 456  MVTLAKS 462
             + LA +
Sbjct: 4303 TLALASN 4309



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 75/244 (30%), Positives = 112/244 (45%), Gaps = 21/244 (8%)

Query: 172  QETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ 231
            Q   V+Q+SCG  HS V+T    +F+ GN  YG+ G     N+   E  RV  ++ +  Q
Sbjct: 4132 QGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPE--RVTALEGY--Q 4187

Query: 232  VVQVACGQDHSLFLTDKGE-VYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290
            + QVACG +H+L ++  G  V++ G G  G+ GLG+    SSP K+   L G+ + +VA 
Sbjct: 4188 IGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKI-DVLCGIGIKKVAC 4246

Query: 291  YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAV 350
                 +A++ DG ++ +G    + L     +   N P+ +       +   A G      
Sbjct: 4247 GTQFSVALTKDGHVYTFGQDRLIGLPE-GRARNHNRPQQIPVLAGVIIEDVAVGAEHTLA 4305

Query: 351  LNGEGHVFVWG---YGILGKG-PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHF 406
            L   G V+ WG    G LG G  N V        P  + GL   N    V +I  G  H 
Sbjct: 4306 LASNGDVYAWGSNSEGQLGLGHTNHVRE------PTLVTGLQGKN----VRQISAGRCHS 4355

Query: 407  AALT 410
            AA T
Sbjct: 4356 AAWT 4359



 Score = 78.2 bits (191), Expect = 1e-14
 Identities = 72/250 (28%), Positives = 112/250 (44%), Gaps = 23/250 (9%)

Query: 185 HSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ-VACGQDHSL 243
           H+L  T    VFS G+  YG+ G      + Y +  +        G+VV  V+ G  HS 
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQ----GPLQGKVVVCVSAGYRHSA 524

Query: 244 FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGG 303
            +T+ GE+Y+ G G  G+ G G  N  + PT L  D++  NV +V+      +A+S DG 
Sbjct: 525 AVTEDGELYTWGEGDFGRLGHGDSNSRNIPT-LVKDIS--NVGEVSCGSSHTIALSKDGR 581

Query: 304 L---FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360
               FG G++  L      D+ +V  P+ +       +R+   G      L   G V+ W
Sbjct: 582 TVWSFGGGDNGKLGHG---DTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAW 638

Query: 361 GYGI-LGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419
           G G  LG G +   +  P++I        E     ++  +  G SH  AL++  E++ WG
Sbjct: 639 GCGACLGCGSSEATALRPKLI--------EELAATRIVDVSIGDSHCLALSHDNEVYAWG 690

Query: 420 KNIRGCLGIG 429
            N  G  G G
Sbjct: 691 NNSMGQCGQG 700



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 69/260 (26%), Positives = 113/260 (43%), Gaps = 23/260 (8%)

Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE-----IYSESHRVHRMQDFDGQVV 233
           +  G+  + V++    V + G  SYG+ G     N+     +  E HR  +        V
Sbjct: 408 IEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKK-------V 460

Query: 234 QVACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292
             + G D H+L  T +GEV+S G G  G+ G G+ +    P  + G L G  V+ V+   
Sbjct: 461 SSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGY 520

Query: 293 DCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLN 352
               AV+ DG L+ WG  ++ +L    DS   N+P  +    +  V + +CG +    L+
Sbjct: 521 RHSAAVTEDGELYTWGEGDFGRLGH-GDSNSRNIPTLV--KDISNVGEVSCGSSHTIALS 577

Query: 353 GEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412
            +G   VW +G  G    L       +  P +    E    + + ++  G     ALT+ 
Sbjct: 578 KDGRT-VWSFG-GGDNGKLGHGDTNRVYKPKVI---EALQGMFIRKVCAGSQSSLALTST 632

Query: 413 GELFVWGKNIRGCLGIGRLE 432
           G+++ WG     CLG G  E
Sbjct: 633 GQVYAWG--CGACLGCGSSE 650



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 45/160 (28%), Positives = 77/160 (48%), Gaps = 15/160 (9%)

Query: 174 TRVLQVSCGRAHSLVLT-DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHR---MQDFD 229
           + V +VSCG +H++ L+ D   V+S G    G+ G        + +++RV++   ++   
Sbjct: 561 SNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLG--------HGDTNRVYKPKVIEALQ 612

Query: 230 GQVVQVAC-GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288
           G  ++  C G   SL LT  G+VY+  WG     G G    T+   KL  +LA   ++ V
Sbjct: 613 GMFIRKVCAGSQSSLALTSTGQVYA--WGCGACLGCGSSEATALRPKLIEELAATRIVDV 670

Query: 289 ATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 328
           +     CLA+S D  ++ WGN+   Q      +  +  P+
Sbjct: 671 SIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPK 710



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 74/267 (27%), Positives = 108/267 (40%), Gaps = 38/267 (14%)

Query: 210  VVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNI 269
            V E+E+         +   D Q++  A  +     L  K +VY  G G  GQ      N+
Sbjct: 3958 VPEDELVFLMDNSKWINGMDEQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNV 4017

Query: 270  TSSPTKLGGDLAGVNVIQVATYGDCCLAVSADG----------GLFGWGNSEYLQLASVT 319
                       A     QV    +C   + A+G          G  G GNS+ L + +V 
Sbjct: 4018 MVPAAAPSFSQAQ----QVICGQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVI 4073

Query: 320  DSTQVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESA 375
             + Q  V   L  S         CG  G ++ L   G VF WG   YG LG G N     
Sbjct: 4074 SALQGFVVTQLVTS---------CGSDGHSMALTESGEVFSWGDGDYGKLGHG-NSDRQR 4123

Query: 376  VPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQY 435
             P  I        E     +V ++ CG  H A +T+ G+LF +G    G LG+G   ++ 
Sbjct: 4124 RPRQI--------EALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKK 4175

Query: 436  FPWRVT-MPGEPV-DVACGVDHMVTLA 460
             P RVT + G  +  VACG++H + ++
Sbjct: 4176 LPERVTALEGYQIGQVACGLNHTLAVS 4202



 Score = 66.6 bits (161), Expect = 4e-11
 Identities = 63/218 (28%), Positives = 85/218 (38%), Gaps = 18/218 (8%)

Query: 250 EVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGN 309
           EVY  G  +  Q   G       P KL    +    I+   Y  C   +S DG +   G 
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQP-KLAPSFSDAQTIEAGQY--CTFVISTDGSVRACGK 429

Query: 310 SEYLQLASVTDSTQVNVPRCLHFS---GVGKVRQAACGGTGCAVLNGEGHVFVWG---YG 363
             Y +L  + DS   +  + L F     + KV  +            EG VF WG   YG
Sbjct: 430 GSYGRLG-LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYG 488

Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
            LG G N      P++I   L G         V  +  G  H AA+T  GEL+ WG+   
Sbjct: 489 KLGHG-NSSTQKYPKLIQGPLQGKV-------VVCVSAGYRHSAAVTEDGELYTWGEGDF 540

Query: 424 GCLGIGRLEDQYFPWRVTMPGEPVDVACGVDHMVTLAK 461
           G LG G    +  P  V       +V+CG  H + L+K
Sbjct: 541 GRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIALSK 578



 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 59/195 (30%), Positives = 87/195 (44%), Gaps = 36/195 (18%)

Query: 108  KISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLP 167
            +I   ACG   TL  S  AD + VW  G     +LG   S    +               
Sbjct: 4187 QIGQVACGLNHTLAVS--ADGSMVWAFGDGDYGKLGLGNSTAKSS--------------- 4229

Query: 168  LDRPQETRVL------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESH- 220
               PQ+  VL      +V+CG   S+ LT    V++ G +      R +   E  + +H 
Sbjct: 4230 ---PQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQD------RLIGLPEGRARNHN 4280

Query: 221  RVHRMQDFDGQVVQ-VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279
            R  ++    G +++ VA G +H+L L   G+VY+ G  ++GQ GLGH N    PT + G 
Sbjct: 4281 RPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTG- 4339

Query: 280  LAGVNVIQVATYGDC 294
            L G NV Q++  G C
Sbjct: 4340 LQGKNVRQISA-GRC 4353



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 48/203 (23%), Positives = 83/203 (40%), Gaps = 21/203 (10%)

Query: 99  VPYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYV 158
           +P  ++    +   +CG   T+  SK  D   VW  G   + +LG      D  R Y+  
Sbjct: 553 IPTLVKDISNVGEVSCGSSHTIALSK--DGRTVWSFGGGDNGKLG----HGDTNRVYKPK 606

Query: 159 LEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSE 218
           +        ++  Q   + +V  G   SL LT    V++ G  +   CG         + 
Sbjct: 607 V--------IEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSE------AT 652

Query: 219 SHRVHRMQDFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
           + R   +++    ++V V+ G  H L L+   EVY+ G  + GQ G G+     +  K  
Sbjct: 653 ALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKV 712

Query: 278 GDLAGVNVIQVATYGDCCLAVSA 300
             L G+ + Q++      LA +A
Sbjct: 713 SGLDGIAIQQISAGTSHSLAWTA 735


>gi|4557445 regulator of chromosome condensation and BTB domain
           containing protein 2 [Homo sapiens]
          Length = 551

 Score =  100 bits (250), Expect = 2e-21
 Identities = 80/259 (30%), Positives = 119/259 (45%), Gaps = 20/259 (7%)

Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREG-VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQ 226
           LD     ++  +S G    +VL   EG VF+ G+N+Y Q G     + +       H   
Sbjct: 92  LDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVP----CHIST 147

Query: 227 DFDG-QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNV 285
           +    QV++VACG  HSL LT  GEV++ G+   GQ G G       P ++ G L    V
Sbjct: 148 NLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVV 207

Query: 286 IQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGG 345
           + +A    CC+AV   G ++ WG +   QL       Q    R     G+ +V++ ACG 
Sbjct: 208 VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGI-RVQRVACGY 266

Query: 346 TGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCG 402
               VL  EG V+ WG   YG LG G N    + P  +        E +  I+++   C 
Sbjct: 267 AHTLVLTDEGQVYAWGANSYGQLGTG-NKSNQSYPTPV------TVEKDRIIEIA--ACH 317

Query: 403 LSH-FAALTNKGELFVWGK 420
            +H  AA T  G +++WG+
Sbjct: 318 STHTSAAKTQGGHVYMWGQ 336



 Score = 99.4 bits (246), Expect = 6e-21
 Identities = 83/283 (29%), Positives = 135/283 (47%), Gaps = 29/283 (10%)

Query: 172 QETRVLQVSC--GRAHSLVL--TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227
           +E ++++ +C  G A + VL  T  + +F +G N  G  G   V++ I        R+  
Sbjct: 40  EELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQSTI-----EPRRLDS 94

Query: 228 FDGQVVQVAC----GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283
            +G+  ++AC       H +  T +GEV++ G  A  Q G G  N    P  +  +L+  
Sbjct: 95  LNGK--KIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNK 152

Query: 284 NVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR----CLHFSGVGKVR 339
            VI+VA      L +++DG +F WG +   Q+ S +   Q  +PR    CL    V  + 
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQP-IPRRVTGCLQNKVVVTI- 210

Query: 340 QAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRI 399
             ACG   C  +   G V+VWGY   G G   + ++  +  P  +  L      I+V R+
Sbjct: 211 --ACGQMCCMAVVDTGEVYVWGYN--GNGQLGLGNSGNQPTPCRVAALQG----IRVQRV 262

Query: 400 RCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 442
            CG +H   LT++G+++ WG N  G LG G   +Q +P  VT+
Sbjct: 263 ACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTV 305



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 43/154 (27%), Positives = 66/154 (42%), Gaps = 39/154 (25%)

Query: 61  VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQ--KISSAACGYGF 118
           V+VWG++ +G LG     + +SG             QP P R+   Q  ++   ACGY  
Sbjct: 226 VYVWGYNGNGQLG-----LGNSGN------------QPTPCRVAALQGIRVQRVACGYAH 268

Query: 119 TLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQ 178
           TL+     D  +V+  G N   QLG   +     + Y     P+PV++  DR  E     
Sbjct: 269 TLV---LTDEGQVYAWGANSYGQLG---TGNKSNQSY-----PTPVTVEKDRIIEI---- 313

Query: 179 VSCGRAHSLVLTDREGVFSMGNNSYGQC-GRKVV 211
            +C   H+     + G   M    +GQC G+ V+
Sbjct: 314 AACHSTHTSAAKTQGGHVYM----WGQCRGQSVI 343


>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
           (POZ) domain containing protein 1 [Homo sapiens]
          Length = 531

 Score = 92.8 bits (229), Expect = 6e-19
 Identities = 81/289 (28%), Positives = 133/289 (46%), Gaps = 29/289 (10%)

Query: 171 PQETRVLQVSC----GRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQ 226
           PQE   ++ +C      + +L +TD + VF  G N     G    ++ +  +     +++
Sbjct: 15  PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPK-----KLE 69

Query: 227 DFDGQVVQ-VACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284
              G+ ++ ++ G   H L  T+ G VY+ G     Q G G  N   +P ++  +L    
Sbjct: 70  GLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQ 129

Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQV---NVPRCLHFSGVGKVRQA 341
           V++VA      +A++ADG +F WG +   Q+ S + + Q     V  CLH   + +V   
Sbjct: 130 VVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGI 186

Query: 342 ACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 398
           ACG T    +   G V+ WGY   G LG G N       ++ P  +  L      + V++
Sbjct: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-----GNQLTPVRVAAL----HSVCVNQ 237

Query: 399 IRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV 447
           I CG +H  ALT++G L+ WG N  G LG G   +   P  + +  E V
Sbjct: 238 IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERV 286



 Score = 57.4 bits (137), Expect = 3e-08
 Identities = 45/159 (28%), Positives = 67/159 (42%), Gaps = 13/159 (8%)

Query: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
           RV+ ++CG+  S+ + D   V+  G N  GQ G     N++     RV  +      V Q
Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPV--RVAALHSVC--VNQ 237

Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294
           + CG  H+L LTD+G +Y+ G    GQ G G+ N   SP  +  +   V  I        
Sbjct: 238 IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHT 297

Query: 295 CLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 333
             A +  G ++ WG               V +P   HFS
Sbjct: 298 SAAKTQGGHVYMWGQCR---------GQSVILPHLTHFS 327


>gi|126032348 hect domain and RLD 2 [Homo sapiens]
          Length = 4834

 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 88/289 (30%), Positives = 125/289 (43%), Gaps = 28/289 (9%)

Query: 179  VSCGRAHSLVLTDREGVFSMGNNSYGQCG---RKVVENEIYSESHRVHRMQDFDGQVVQV 235
            V  G  H+  LT    VFS G    G+ G   R   +     E+ +  R++D       +
Sbjct: 3052 VHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRD-------I 3104

Query: 236  ACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVA--TYGD 293
            ACG  HS  LT  GE+Y+ G G  G+ G G  N T    K+   L G  VIQVA  +   
Sbjct: 3105 ACGSSHSAALTSSGELYTWGLGEYGRLGHGD-NTTQLKPKMVKVLLGHRVIQVACGSRDA 3163

Query: 294  CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
              LA++ +G +F WG+ ++ +L     S   N+P+ +       V Q  CG      L  
Sbjct: 3164 QTLALTDEGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTK 3222

Query: 354  EGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410
             G V+ WG   Y  LG G     S V    P  + GL       ++  +  G  H  A+T
Sbjct: 3223 SGVVWTWGKGDYFRLGHG-----SDVHVRKPQVVEGLR----GKKIVHVAVGALHCLAVT 3273

Query: 411  NKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPVD-VACGVDHMV 457
            + G+++ WG N  G  G G       P  V  + G+ +  VACG  H V
Sbjct: 3274 DSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSV 3322



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 82/290 (28%), Positives = 123/290 (42%), Gaps = 40/290 (13%)

Query: 130  KVWGMGLNKDSQLG-FHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLV 188
            KV+  G   D +LG F R   DK R  E +             +  R+  ++CG +HS  
Sbjct: 3067 KVFSWGEGDDGKLGHFSRMNCDKPRLIEAL-------------KTKRIRDIACGSSHSAA 3113

Query: 189  LTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV---HRMQDFDGQVVQVACG--QDHSL 243
            LT    +++ G   YG+ G      ++  +  +V   HR       V+QVACG     +L
Sbjct: 3114 LTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHR-------VIQVACGSRDAQTL 3166

Query: 244  FLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGG 303
             LTD+G V+S G G  G+ G G     + P  +   L G  V Q+       LA++  G 
Sbjct: 3167 ALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNI-ERLNGQGVCQIECGAQFSLALTKSGV 3225

Query: 304  LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG-- 361
            ++ WG  +Y +L   +D   V  P+ +      K+   A G   C  +   G V+ WG  
Sbjct: 3226 VWTWGKGDYFRLGHGSD-VHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDN 3284

Query: 362  -YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALT 410
             +G  G G   V         PTL    E     +++R+ CG SH  A T
Sbjct: 3285 DHGQQGNGTTTVNR------KPTLVQGLEGQ---KITRVACGSSHSVAWT 3325



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 83/304 (27%), Positives = 124/304 (40%), Gaps = 48/304 (15%)

Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNS--------YGQCGRKVVENEIYSESHRVHRMQD 227
           V Q++C     L+L+    V++   NS         G   R +V+   +S+ H       
Sbjct: 453 VTQIACAEKRFLILSRNGRVYTQAYNSDTLAPQLVQGLASRNIVKIAAHSDGH------- 505

Query: 228 FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP---TKLGGDLAGVN 284
                        H L L   GEVYS G G  G+ G G       P   +   G  AG +
Sbjct: 506 -------------HYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKH 552

Query: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACG 344
           V+ +A       A++A+G L+ WG   Y +L   +   +          G+ KV   ACG
Sbjct: 553 VVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGL-KVIDVACG 611

Query: 345 GTGCAVL--NGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRI 399
                 L     G V+ WG   YG LG+G +      P++I        E   ++ V ++
Sbjct: 612 SGDAQTLAVTENGQVWSWGDGDYGKLGRGGS-DGCKTPKLI--------EKLQDLDVVKV 662

Query: 400 RCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 457
           RCG     ALT  G+++ WGK     LG G  E   +P  +  + G+ V DVA G  H +
Sbjct: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCL 722

Query: 458 TLAK 461
            L +
Sbjct: 723 ALTE 726



 Score = 86.3 bits (212), Expect = 5e-17
 Identities = 83/283 (29%), Positives = 127/283 (44%), Gaps = 25/283 (8%)

Query: 190  TDREGVFSMGNNSYGQCGR-KVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDK 248
            T R  VF  G N   Q G  K  + ++ S S  +  +      VVQVA G      +T +
Sbjct: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALN-----VVQVAGGSKSLFAVTVE 3010

Query: 249  GEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY--GDCCLAVSADGGLFG 306
            G+VY+CG   +G+ GLG  + T    +    L+   V +VA +  G    A++ DG +F 
Sbjct: 3011 GKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFS 3070

Query: 307  WGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YG 363
            WG  +  +L   +     + PR +      ++R  ACG +  A L   G ++ WG   YG
Sbjct: 3071 WGEGDDGKLGHFS-RMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYG 3129

Query: 364  ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGL--SHFAALTNKGELFVWGKN 421
             LG G N  +   P+M+   L          +V ++ CG   +   ALT++G +F WG  
Sbjct: 3130 RLGHGDNTTQ-LKPKMVKVLL--------GHRVIQVACGSRDAQTLALTDEGLVFSWGDG 3180

Query: 422  IRGCLGIGRLEDQYFPWRV-TMPGEPV-DVACGVDHMVTLAKS 462
              G LG G  E    P  +  + G+ V  + CG    + L KS
Sbjct: 3181 DFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKS 3223



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 69/250 (27%), Positives = 112/250 (44%), Gaps = 20/250 (8%)

Query: 167  PLDRPQETR------VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESH 220
            P DRP+         V+ V+ G AHS  +T    +++ G   YG+ G    E+++  +  
Sbjct: 4078 PCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQL--KPK 4135

Query: 221  RVHRMQDFDGQVVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGG 278
             V  +Q    +VV +ACG     +L LTD   V+S G G  G+ G G  +    P K+  
Sbjct: 4136 LVEALQGH--RVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKI-D 4192

Query: 279  DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 338
             L G+ V++V       +A++  G ++ WG  +Y +L   +D   V  PR +      KV
Sbjct: 4193 SLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDD-HVRRPRQVQGLQGKKV 4251

Query: 339  RQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 398
               A G   C     +G V+ WG    G+  +   +A+     P L    +     +V+R
Sbjct: 4252 IAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQR---PRLVAALQGK---KVNR 4305

Query: 399  IRCGLSHFAA 408
            + CG +H  A
Sbjct: 4306 VACGSAHTLA 4315



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 56/204 (27%), Positives = 96/204 (47%), Gaps = 8/204 (3%)

Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSES 219
           EP  +S    +     V+ ++CG  +S  +T    +++ G  +YG+ G    E+E  +  
Sbjct: 537 EPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDE--AIP 594

Query: 220 HRVHRMQDFDGQVVQVACGQD--HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
             V  ++    +V+ VACG     +L +T+ G+V+S G G  G+ G G  +   +P KL 
Sbjct: 595 MLVAGLKGL--KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTP-KLI 651

Query: 278 GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGK 337
             L  ++V++V       +A++ DG ++ WG  +  +L   T+   V  P+ L      K
Sbjct: 652 EKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEE-HVRYPKLLEGLQGKK 710

Query: 338 VRQAACGGTGCAVLNGEGHVFVWG 361
           V   A G T C  L  +  V  WG
Sbjct: 711 VIDVAAGSTHCLALTEDSEVHSWG 734



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 49/142 (34%), Positives = 73/142 (51%), Gaps = 7/142 (4%)

Query: 175 RVLQVSCGR--AHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQV 232
           +V+ V+CG   A +L +T+   V+S G+  YG+ GR   +         + ++QD D  V
Sbjct: 604 KVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDG--CKTPKLIEKLQDLD--V 659

Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292
           V+V CG   S+ LT  G+VYS G G + + G G       P  L G L G  VI VA   
Sbjct: 660 VKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEG-LQGKKVIDVAAGS 718

Query: 293 DCCLAVSADGGLFGWGNSEYLQ 314
             CLA++ D  +  WG+++  Q
Sbjct: 719 THCLALTEDSEVHSWGSNDQCQ 740



 Score = 72.8 bits (177), Expect = 6e-13
 Identities = 85/290 (29%), Positives = 124/290 (42%), Gaps = 20/290 (6%)

Query: 179  VSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQVAC 237
            V+ G  H L L+    V+S G    G+ G     N    +  RV  ++   G +VV VA 
Sbjct: 4044 VNSGGKHCLALSSEGEVYSWGEAEDGKLGHG---NRSPCDRPRV--IESLRGIEVVDVAA 4098

Query: 238  GQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDC-C 295
            G  HS  +T  G++Y+ G G  G+ G         P KL   L G  V+ +A   GD   
Sbjct: 4099 GGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKP-KLVEALQGHRVVDIACGSGDAQT 4157

Query: 296  LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLH-FSGVGKVRQAACGGTGCAVLNGE 354
            L ++ D  ++ WG+ +Y +L     S    VP  +   +G+G V+   CG      L   
Sbjct: 4158 LCLTDDDTVWSWGDGDYGKLGR-GGSDGCKVPMKIDSLTGLGVVK-VECGSQFSVALTKS 4215

Query: 355  GHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGE 414
            G V+ WG G   +  +  +  V    P  + GL       +V  I  G  H    T  GE
Sbjct: 4216 GAVYTWGKGDYHRLGHGSDDHVRR--PRQVQGLQGK----KVIAIATGSLHCVCCTEDGE 4269

Query: 415  LFVWGKNIRGCLGIGRLEDQYFPWRV-TMPGEPVD-VACGVDHMVTLAKS 462
            ++ WG N  G LG G       P  V  + G+ V+ VACG  H +  + S
Sbjct: 4270 VYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWSTS 4319



 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 72/244 (29%), Positives = 107/244 (43%), Gaps = 20/244 (8%)

Query: 185 HSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-----VVQVACGQ 239
           H L L     V+S G    G+ G     + +  E  +V  +  F G+     VV +ACG 
Sbjct: 506 HYLALAATGEVYSWGCGDGGRLGHG---DTVPLEEPKV--ISAFSGKQAGKHVVHIACGS 560

Query: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT-YGDC-CLA 297
            +S  +T +GE+Y+ G G  G+ G G     + P  + G L G+ VI VA   GD   LA
Sbjct: 561 TYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAG-LKGLKVIDVACGSGDAQTLA 619

Query: 298 VSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHV 357
           V+ +G ++ WG+ +Y +L     S     P+ +       V +  CG      L  +G V
Sbjct: 620 VTENGQVWSWGDGDYGKLGR-GGSDGCKTPKLIEKLQDLDVVKVRCGSQFSIALTKDGQV 678

Query: 358 FVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFV 417
           + WG G   +  +  E  V    P  L GL       +V  +  G +H  ALT   E+  
Sbjct: 679 YSWGKGDNQRLGHGTEEHV--RYPKLLEGLQGK----KVIDVAAGSTHCLALTEDSEVHS 732

Query: 418 WGKN 421
           WG N
Sbjct: 733 WGSN 736



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 77/255 (30%), Positives = 110/255 (43%), Gaps = 21/255 (8%)

Query: 214  EIYSESHRVHRMQDFDGQVVQVACGQ--DHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271
            ++  ESH + + +  D Q+VQ    +  D +L     G +Y  G    GQ G        
Sbjct: 3916 DVLHESHDIFKREQ-DEQLVQWMNRRPDDWTLSAGGSGTIYGWGHNHRGQLGGIEGAKVK 3974

Query: 272  SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLH 331
             PT     LA +  +Q+        AV+ADG L+  G     +L  +  +  V+ P  L 
Sbjct: 3975 VPTPCEA-LATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGRLG-IGGTESVSTPTLLE 4032

Query: 332  FSGVGKVRQAAC--GGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFG 386
                  +++ A   GG  C  L+ EG V+ WG    G LG G N      P +I  +L G
Sbjct: 4033 SIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHG-NRSPCDRPRVIE-SLRG 4090

Query: 387  LTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV-TMPG- 444
                   I+V  +  G +H A +T  G+L+ WGK   G LG    EDQ  P  V  + G 
Sbjct: 4091 -------IEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGH 4143

Query: 445  EPVDVACGVDHMVTL 459
              VD+ACG     TL
Sbjct: 4144 RVVDIACGSGDAQTL 4158



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 54/185 (29%), Positives = 78/185 (42%), Gaps = 24/185 (12%)

Query: 108  KISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLP 167
            ++   ACG G       T D T VW  G     +LG  R   D  +          V + 
Sbjct: 4144 RVVDIACGSGDAQTLCLTDDDT-VWSWGDGDYGKLG--RGGSDGCK----------VPMK 4190

Query: 168  LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESH--RVHRM 225
            +D      V++V CG   S+ LT    V++ G   Y + G         S+ H  R  ++
Sbjct: 4191 IDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHG-------SDDHVRRPRQV 4243

Query: 226  QDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284
            Q   G+ V+ +A G  H +  T+ GEVY+ G   +GQ G G  N    P +L   L G  
Sbjct: 4244 QGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRP-RLVAALQGKK 4302

Query: 285  VIQVA 289
            V +VA
Sbjct: 4303 VNRVA 4307



 Score = 31.6 bits (70), Expect = 1.6
 Identities = 29/100 (29%), Positives = 42/100 (42%), Gaps = 15/100 (15%)

Query: 106 DQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVS 165
           D  +    CG  F++  +K   V   WG G N+  +LG            E+V  P    
Sbjct: 656 DLDVVKVRCGSQFSIALTKDGQVYS-WGKGDNQ--RLGHGTE--------EHVRYPKL-- 702

Query: 166 LPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQ 205
             L+  Q  +V+ V+ G  H L LT+   V S G+N   Q
Sbjct: 703 --LEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSNDQCQ 740


>gi|110825982 hect domain and RLD 5 [Homo sapiens]
          Length = 1024

 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 66/231 (28%), Positives = 113/231 (48%), Gaps = 10/231 (4%)

Query: 209 KVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYN 268
           K  E + YS  H        + +++Q+ CG  HSL L+  GE+++ G    GQ G+G   
Sbjct: 117 KPFEYDNYSMKHLRFESILQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKF 176

Query: 269 ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPR 328
            +++  ++   LAGV + Q++      +A+S  G ++ WG +E  QL  +  +   + P 
Sbjct: 177 PSTTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQL-GLGHTESKDDPS 235

Query: 329 CLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGL 387
            +      KV   ACGG+  A+L  +G +F +G G  G+ G N  ++ +   +   L G 
Sbjct: 236 LIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVG- 294

Query: 388 TEFNPEIQVSRIRCGLSH-FAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
                  +V++I CG  H  A +++ G++F +G    G LG G   DQ  P
Sbjct: 295 ------YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMP 339



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 63/195 (32%), Positives = 96/195 (49%), Gaps = 10/195 (5%)

Query: 172 QETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG- 230
           QE +++Q++CG  HSL L+    +F+ G N +GQ G        +  +     ++   G 
Sbjct: 136 QEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLG----VGRKFPSTTTPQIVEHLAGV 191

Query: 231 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVAT 290
            + Q++ G+ HS+ L+  G +YS G    GQ GLGH      P+ + G L    V  VA 
Sbjct: 192 PLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG-LDNQKVEFVAC 250

Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVG-KVRQAACG-GTGC 348
            G     ++ DG LF +G  ++ QL    +STQ  +  CL    VG +V Q ACG     
Sbjct: 251 GGSHSALLTQDGLLFTFGAGKHGQLGH--NSTQNELRPCLVAELVGYRVTQIACGRWHTL 308

Query: 349 AVLNGEGHVFVWGYG 363
           A ++  G VF +G G
Sbjct: 309 AYVSDLGKVFSFGSG 323



 Score = 62.0 bits (149), Expect = 1e-09
 Identities = 59/217 (27%), Positives = 98/217 (45%), Gaps = 46/217 (21%)

Query: 56  ARADRVFVWGFSFSGALGV----PSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISS 111
           ++   +F WG +  G LGV    PS   P          +    +  VP        ++ 
Sbjct: 154 SKGGELFAWGQNLHGQLGVGRKFPSTTTP----------QIVEHLAGVP--------LAQ 195

Query: 112 AACGYGFTLLSSKTADVTKVWGMGLNKDSQLGF-HRSRKDKTRGYEYVLEPSPVSLPLDR 170
            + G   ++  S + +   ++  G N+  QLG  H   KD         +PS +    + 
Sbjct: 196 ISAGEAHSMALSMSGN---IYSWGKNECGQLGLGHTESKD---------DPSLI----EG 239

Query: 171 PQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG 230
               +V  V+CG +HS +LT    +F+ G   +GQ G    +NE+     R   + +  G
Sbjct: 240 LDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNEL-----RPCLVAELVG 294

Query: 231 -QVVQVACGQDHSL-FLTDKGEVYSCGWGADGQTGLG 265
            +V Q+ACG+ H+L +++D G+V+S G G DGQ G G
Sbjct: 295 YRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNG 331


>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
           sapiens]
          Length = 438

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)

Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
           P  + + + +  A  G   T+  SK+    +V+  G N +  LG    R     G E V 
Sbjct: 77  PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 128

Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
            P  V L      + +V+QVS G +H+  LTD   VF  G+  ++ G  G  ++E     
Sbjct: 129 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 176

Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
           +   V      D  VV+VA G DH + LT  G++Y+ G G  GQ G       +   + G
Sbjct: 177 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 236

Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
                          G    V             A+S +G ++G+G S Y QL +    +
Sbjct: 237 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 296

Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
                    F    K      GG    V ++ EG  +  G   YG LG G    E ++P 
Sbjct: 297 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 356

Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
           +I               VS + CG S   A+T  G +F WG      LG G+ ED + P 
Sbjct: 357 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 405

Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
            V M G+ ++      V+ G  H V L K
Sbjct: 406 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 433



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 20/63 (31%), Positives = 32/63 (50%), Gaps = 1/63 (1%)

Query: 401 CGLSHFAALTNKGELFVWGKNIRGCLGIG-RLEDQYFPWRVTMPGEPVDVACGVDHMVTL 459
           C +SH +  T  G +   G+   G LG+G  + ++  P  V++P + V    G  H V L
Sbjct: 40  CQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVVQAEAGGMHTVCL 99

Query: 460 AKS 462
           +KS
Sbjct: 100 SKS 102


>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
           sapiens]
          Length = 452

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)

Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
           P  + + + +  A  G   T+  SK+    +V+  G N +  LG    R     G E V 
Sbjct: 91  PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 142

Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
            P  V L      + +V+QVS G +H+  LTD   VF  G+  ++ G  G  ++E     
Sbjct: 143 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 190

Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
           +   V      D  VV+VA G DH + LT  G++Y+ G G  GQ G       +   + G
Sbjct: 191 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 250

Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
                          G    V             A+S +G ++G+G S Y QL +    +
Sbjct: 251 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 310

Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
                    F    K      GG    V ++ EG  +  G   YG LG G    E ++P 
Sbjct: 311 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 370

Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
           +I               VS + CG S   A+T  G +F WG      LG G+ ED + P 
Sbjct: 371 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 419

Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
            V M G+ ++      V+ G  H V L K
Sbjct: 420 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 447


>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
           sapiens]
          Length = 421

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)

Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
           P  + + + +  A  G   T+  SK+    +V+  G N +  LG    R     G E V 
Sbjct: 60  PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111

Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
            P  V L      + +V+QVS G +H+  LTD   VF  G+  ++ G  G  ++E     
Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159

Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
           +   V      D  VV+VA G DH + LT  G++Y+ G G  GQ G       +   + G
Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219

Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
                          G    V             A+S +G ++G+G S Y QL +    +
Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279

Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
                    F    K      GG    V ++ EG  +  G   YG LG G    E ++P 
Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339

Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
           +I               VS + CG S   A+T  G +F WG      LG G+ ED + P 
Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388

Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
            V M G+ ++      V+ G  H V L K
Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416


>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)

Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
           P  + + + +  A  G   T+  SK+    +V+  G N +  LG    R     G E V 
Sbjct: 60  PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111

Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
            P  V L      + +V+QVS G +H+  LTD   VF  G+  ++ G  G  ++E     
Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159

Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
           +   V      D  VV+VA G DH + LT  G++Y+ G G  GQ G       +   + G
Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219

Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
                          G    V             A+S +G ++G+G S Y QL +    +
Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279

Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
                    F    K      GG    V ++ EG  +  G   YG LG G    E ++P 
Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339

Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
           +I               VS + CG S   A+T  G +F WG      LG G+ ED + P 
Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388

Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
            V M G+ ++      V+ G  H V L K
Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416


>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)

Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
           P  + + + +  A  G   T+  SK+    +V+  G N +  LG    R     G E V 
Sbjct: 60  PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111

Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
            P  V L      + +V+QVS G +H+  LTD   VF  G+  ++ G  G  ++E     
Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159

Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
           +   V      D  VV+VA G DH + LT  G++Y+ G G  GQ G       +   + G
Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219

Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
                          G    V             A+S +G ++G+G S Y QL +    +
Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279

Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
                    F    K      GG    V ++ EG  +  G   YG LG G    E ++P 
Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339

Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
           +I               VS + CG S   A+T  G +F WG      LG G+ ED + P 
Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388

Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
            V M G+ ++      V+ G  H V L K
Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416


>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
          Length = 421

 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 105/389 (26%), Positives = 154/389 (39%), Gaps = 59/389 (15%)

Query: 100 PYRLELDQKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVL 159
           P  + + + +  A  G   T+  SK+    +V+  G N +  LG    R     G E V 
Sbjct: 60  PALVSIPEDVVQAEAGGMHTVCLSKSG---QVYSFGCNDEGALG----RDTSVEGSEMV- 111

Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGN--NSYGQCGRKVVENEIYS 217
            P  V L      + +V+QVS G +H+  LTD   VF  G+  ++ G  G  ++E     
Sbjct: 112 -PGKVEL------QEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIG--LLEP---M 159

Query: 218 ESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLG 277
           +   V      D  VV+VA G DH + LT  G++Y+ G G  GQ G       +   + G
Sbjct: 160 KKSMVPVQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQG 219

Query: 278 ---------------GDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDST 322
                          G    V             A+S +G ++G+G S Y QL +    +
Sbjct: 220 LERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTES 279

Query: 323 QVNVPRCLHFSGVGKVRQAACGGTGCAV-LNGEGHVFVWG---YGILGKGPNLVESAVPE 378
                    F    K      GG    V ++ EG  +  G   YG LG G    E ++P 
Sbjct: 280 CFIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPT 339

Query: 379 MIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPW 438
           +I               VS + CG S   A+T  G +F WG      LG G+ ED + P 
Sbjct: 340 LISRLP----------AVSSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSP- 388

Query: 439 RVTMPGEPVD------VACGVDHMVTLAK 461
            V M G+ ++      V+ G  H V L K
Sbjct: 389 -VEMMGKQLENRVVLSVSSGGQHTVLLVK 416


>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
           sapiens]
          Length = 815

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 88/342 (25%), Positives = 146/342 (42%), Gaps = 72/342 (21%)

Query: 177 LQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVA 236
           + +SCG  HS V+T    ++  G+N++GQ G  +      S+   V  ++    +V   A
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAA 93

Query: 237 CGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCL 296
           CG++H+L  T+ G VY+ G   +GQ GLG     ++   +    +   + Q++   +   
Sbjct: 94  CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSA 153

Query: 297 AVSADGGLFGWGNSEYLQL-----ASVTDSTQVNVPRCLHFSGVG--------------- 336
           A++ DG LF WG++   Q+     ++V    QV + + + +   G               
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213

Query: 337 ------------------------------KVRQAACGGTGCAVLNGEGHVFVWG---YG 363
                                         KV Q ACGG    VL  E  V+ +G   +G
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272

Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
            LG G  L E++ P++I        E   +  +S I CG +H A +T+ G ++ +G    
Sbjct: 273 QLGLGTFLFETSEPKVI--------ENIRDQTISYISCGENHTALITDIGLMYTFGDGRH 324

Query: 424 GCLGIGRLEDQYFPWRVTMPGEPVD-----VACGVDHMVTLA 460
           G LG+G LE+    +  T+    +      VACG  HMV  A
Sbjct: 325 GKLGLG-LENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 22/240 (9%)

Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292
           V ++CG +HS  +T   ++Y  G    GQ GLG  +  S PT +         +++A  G
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKA--LKPEKVKLAACG 95

Query: 293 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 349
                VS +GG     G  N   L L    +    +V     F+   K++Q + G    A
Sbjct: 96  RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153

Query: 350 VLNGEGHVFVWGYGILGKG--PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFA 407
            L  +G +F+WG    G+    N+    VP+ +       T   P   VS I CG  H A
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203

Query: 408 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 464
            +T  GEL+V+G+   G LG+    L +   P  V+ +P + + VACG +H V L ++ +
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 59/243 (24%), Positives = 109/243 (44%), Gaps = 39/243 (16%)

Query: 60  RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119
           R+F+WG +  G +G+ +                      VP ++ + + +S  +CGY  +
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVC-----------------VPQQVTIGKPVSWISCGYYHS 202

Query: 120 LLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQV 179
              +   ++   +  G  ++ +LG         R  + V E     +P       +V+QV
Sbjct: 203 AFVTTDGEL---YVFGEPENGKLGLPNQLLGNHRTPQLVSE-----IP------EKVIQV 248

Query: 180 SCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
           +CG  H++VLT+   V++ G   +GQ G      E  SE   +  ++D    +  ++CG+
Sbjct: 249 ACGGEHTVVLTEN-AVYTFGLGQFGQLGLGTFLFET-SEPKVIENIRD--QTISYISCGE 304

Query: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS--PTKLGGDLAGVNVIQVATYGDCCLA 297
           +H+  +TD G +Y+ G G  G+ GLG  N T+   PT     L    ++++   G C + 
Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLR--FIVKLVACGGCHMV 362

Query: 298 VSA 300
           V A
Sbjct: 363 VFA 365


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 83.6 bits (205), Expect = 4e-16
 Identities = 88/342 (25%), Positives = 146/342 (42%), Gaps = 72/342 (21%)

Query: 177 LQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVA 236
           + +SCG  HS V+T    ++  G+N++GQ G  +      S+   V  ++    +V   A
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLG--LGSKSAISKPTCVKALKP--EKVKLAA 93

Query: 237 CGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCL 296
           CG++H+L  T+ G VY+ G   +GQ GLG     ++   +    +   + Q++   +   
Sbjct: 94  CGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSA 153

Query: 297 AVSADGGLFGWGNSEYLQL-----ASVTDSTQVNVPRCLHFSGVG--------------- 336
           A++ DG LF WG++   Q+     ++V    QV + + + +   G               
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYV 213

Query: 337 ------------------------------KVRQAACGGTGCAVLNGEGHVFVWG---YG 363
                                         KV Q ACGG    VL  E  V+ +G   +G
Sbjct: 214 FGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-ENAVYTFGLGQFG 272

Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
            LG G  L E++ P++I        E   +  +S I CG +H A +T+ G ++ +G    
Sbjct: 273 QLGLGTFLFETSEPKVI--------ENIRDQTISYISCGENHTALITDIGLMYTFGDGRH 324

Query: 424 GCLGIGRLEDQYFPWRVTMPGEPVD-----VACGVDHMVTLA 460
           G LG+G LE+    +  T+    +      VACG  HMV  A
Sbjct: 325 GKLGLG-LENFTNHFIPTLCSNFLRFIVKLVACGGCHMVVFA 365



 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 70/240 (29%), Positives = 109/240 (45%), Gaps = 22/240 (9%)

Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYG 292
           V ++CG +HS  +T   ++Y  G    GQ GLG  +  S PT +         +++A  G
Sbjct: 38  VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKA--LKPEKVKLAACG 95

Query: 293 DCCLAVSADGG---LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCA 349
                VS +GG     G  N   L L    +    +V     F+   K++Q + G    A
Sbjct: 96  RNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHV--ISFFTSEHKIKQLSAGSNTSA 153

Query: 350 VLNGEGHVFVWGYGILGKG--PNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFA 407
            L  +G +F+WG    G+    N+    VP+ +       T   P   VS I CG  H A
Sbjct: 154 ALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV-------TIGKP---VSWISCGYYHSA 203

Query: 408 ALTNKGELFVWGKNIRGCLGIGR--LEDQYFPWRVT-MPGEPVDVACGVDHMVTLAKSFI 464
            +T  GEL+V+G+   G LG+    L +   P  V+ +P + + VACG +H V L ++ +
Sbjct: 204 FVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLTENAV 263



 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 59/243 (24%), Positives = 109/243 (44%), Gaps = 39/243 (16%)

Query: 60  RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119
           R+F+WG +  G +G+ +                      VP ++ + + +S  +CGY  +
Sbjct: 160 RLFMWGDNSEGQIGLKNVSNVC-----------------VPQQVTIGKPVSWISCGYYHS 202

Query: 120 LLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQV 179
              +   ++   +  G  ++ +LG         R  + V E     +P       +V+QV
Sbjct: 203 AFVTTDGEL---YVFGEPENGKLGLPNQLLGNHRTPQLVSE-----IP------EKVIQV 248

Query: 180 SCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQ 239
           +CG  H++VLT+   V++ G   +GQ G      E  SE   +  ++D    +  ++CG+
Sbjct: 249 ACGGEHTVVLTEN-AVYTFGLGQFGQLGLGTFLFET-SEPKVIENIRD--QTISYISCGE 304

Query: 240 DHSLFLTDKGEVYSCGWGADGQTGLGHYNITSS--PTKLGGDLAGVNVIQVATYGDCCLA 297
           +H+  +TD G +Y+ G G  G+ GLG  N T+   PT     L    ++++   G C + 
Sbjct: 305 NHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLR--FIVKLVACGGCHMV 362

Query: 298 VSA 300
           V A
Sbjct: 363 VFA 365


>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 77/272 (28%), Positives = 124/272 (45%), Gaps = 43/272 (15%)

Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ---- 231
           V+  SC  AHSL++T    ++S G N  GQ G        + ++ RV   +  +G     
Sbjct: 153 VVSGSCA-AHSLLITTEGKLWSWGRNEKGQLG--------HGDTKRVEAPRLIEGLSHEV 203

Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVAT 290
           +V  ACG++H+L LT+ G V++ G    GQ GLG+  +   SP ++  +  G  + ++A 
Sbjct: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261

Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN-----------VPR----CLHFSGV 335
             +  + +   G L+ +G  EY QL   +D   +            VPR     +  +  
Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321

Query: 336 GK--------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGL 387
           G+        VR  ACG     VL+ +  VF WG+G  G+   L  +   + + P L  L
Sbjct: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKL 378

Query: 388 TEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419
            +F P    S+I  G +   A++  G LF WG
Sbjct: 379 FDF-PGRGASQIYAGYTCSFAVSEVGGLFFWG 409



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 84/306 (27%), Positives = 126/306 (41%), Gaps = 52/306 (16%)

Query: 109 ISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPL 168
           I SAACG   TL  ++T     V+  G NK  QLG          G +    PSP  +  
Sbjct: 204 IVSAACGRNHTLALTETG---SVFAFGENKMGQLGL---------GNQTDAVPSPAQIMY 251

Query: 169 DRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV------ 222
           +    T+   ++CG   S+++  +  ++S G   YGQ G    + +  + + R+      
Sbjct: 252 NGQPITK---MACGAEFSMIMDCKGNLYSFGCPEYGQLGHN-SDGKFIARAQRIEYDCEL 307

Query: 223 --HRMQDF-----DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY 267
              R+  F     DGQ++         VACG +H+L L  +  V+S G+G  G+ G    
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367

Query: 268 NITSSP--TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325
                P   KL  D  G    Q+     C  AVS  GGLF WG       A+ T      
Sbjct: 368 KDEMVPRLVKL-FDFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTM 419

Query: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIP 381
            P+ +      ++R  ACG +   V   E  +  WG    +G LG G +  +S+      
Sbjct: 420 YPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEV 478

Query: 382 PTLFGL 387
            TL G+
Sbjct: 479 KTLDGI 484



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 57/224 (25%), Positives = 98/224 (43%), Gaps = 21/224 (9%)

Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 291
           VV  +C   HSL +T +G+++S G    GQ G G      +P  + G L+   ++  A  
Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210

Query: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 351
            +  LA++  G +F +G ++  QL     +  V  P  + ++G   + + ACG     ++
Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269

Query: 352 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 393
           + +G+++ +G   YG LG   +               LV   V   I  T  G     P 
Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329

Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
           + V  + CG +H   L ++  +F WG    G LG    +D+  P
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 55/217 (25%), Positives = 99/217 (45%), Gaps = 27/217 (12%)

Query: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRG----YEYVLEPS 162
           Q I+  ACG  F+++     ++   +  G  +  QLG +   K   R     Y+  L P 
Sbjct: 254 QPITKMACGAEFSMIMDCKGNL---YSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPR 310

Query: 163 PVSLPLDRPQETRVL--------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE 214
            V++ +++ ++ ++L         V+CG  H+LVL  ++ VFS G   YG+ G    ++E
Sbjct: 311 RVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE 370

Query: 215 IYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 273
           +     R+ ++ DF G+   Q+  G   S  +++ G ++   WGA   +       ++  
Sbjct: 371 MVP---RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFF--WGATNTS-----RESTMY 420

Query: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310
            K   DL G  +  +A  G   + V+AD     WG S
Sbjct: 421 PKAVQDLCGWRIRSLAC-GKSSIIVAADESTISWGPS 456



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)

Query: 278 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 334
           G LAGV V  V + G C    L ++ +G L+ WG +E  QL    D+ +V  PR +    
Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200

Query: 335 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 393
              +  AACG      L   G VF +G   +G+ G      AVP   P  +     +N +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254

Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 440
             ++++ CG      +  KG L+ +G    G LG       I R +      +  P RV 
Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313

Query: 441 -----TMPGE--PV------DVACGVDHMVTL 459
                T  G+  PV      DVACG +H + L
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345


>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
          Length = 522

 Score = 82.4 bits (202), Expect = 8e-16
 Identities = 77/272 (28%), Positives = 124/272 (45%), Gaps = 43/272 (15%)

Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ---- 231
           V+  SC  AHSL++T    ++S G N  GQ G        + ++ RV   +  +G     
Sbjct: 153 VVSGSCA-AHSLLITTEGKLWSWGRNEKGQLG--------HGDTKRVEAPRLIEGLSHEV 203

Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY-NITSSPTKLGGDLAGVNVIQVAT 290
           +V  ACG++H+L LT+ G V++ G    GQ GLG+  +   SP ++  +  G  + ++A 
Sbjct: 204 IVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261

Query: 291 YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN-----------VPR----CLHFSGV 335
             +  + +   G L+ +G  EY QL   +D   +            VPR     +  +  
Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321

Query: 336 GK--------VRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGL 387
           G+        VR  ACG     VL+ +  VF WG+G  G+   L  +   + + P L  L
Sbjct: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGR---LGHAEQKDEMVPRLVKL 378

Query: 388 TEFNPEIQVSRIRCGLSHFAALTNKGELFVWG 419
            +F P    S+I  G +   A++  G LF WG
Sbjct: 379 FDF-PGRGASQIYAGYTCSFAVSEVGGLFFWG 409



 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 84/306 (27%), Positives = 126/306 (41%), Gaps = 52/306 (16%)

Query: 109 ISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPL 168
           I SAACG   TL  ++T     V+  G NK  QLG          G +    PSP  +  
Sbjct: 204 IVSAACGRNHTLALTETG---SVFAFGENKMGQLGL---------GNQTDAVPSPAQIMY 251

Query: 169 DRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV------ 222
           +    T+   ++CG   S+++  +  ++S G   YGQ G    + +  + + R+      
Sbjct: 252 NGQPITK---MACGAEFSMIMDCKGNLYSFGCPEYGQLGHN-SDGKFIARAQRIEYDCEL 307

Query: 223 --HRMQDF-----DGQVV--------QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHY 267
              R+  F     DGQ++         VACG +H+L L  +  V+S G+G  G+ G    
Sbjct: 308 VPRRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQ 367

Query: 268 NITSSP--TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVN 325
                P   KL  D  G    Q+     C  AVS  GGLF WG       A+ T      
Sbjct: 368 KDEMVPRLVKL-FDFPGRGASQIYAGYTCSFAVSEVGGLFFWG-------ATNTSRESTM 419

Query: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG----YGILGKGPNLVESAVPEMIP 381
            P+ +      ++R  ACG +   V   E  +  WG    +G LG G +  +S+      
Sbjct: 420 YPKAVQDLCGWRIRSLACGKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEV 478

Query: 382 PTLFGL 387
            TL G+
Sbjct: 479 KTLDGI 484



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 57/224 (25%), Positives = 98/224 (43%), Gaps = 21/224 (9%)

Query: 232 VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATY 291
           VV  +C   HSL +T +G+++S G    GQ G G      +P  + G L+   ++  A  
Sbjct: 153 VVSGSCAA-HSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEG-LSHEVIVSAACG 210

Query: 292 GDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVL 351
            +  LA++  G +F +G ++  QL     +  V  P  + ++G   + + ACG     ++
Sbjct: 211 RNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQ-PITKMACGAEFSMIM 269

Query: 352 NGEGHVFVWG---YGILGKGPN---------------LVESAVPEMIPPTLFGLTEFNPE 393
           + +G+++ +G   YG LG   +               LV   V   I  T  G     P 
Sbjct: 270 DCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329

Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
           + V  + CG +H   L ++  +F WG    G LG    +D+  P
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVP 373



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 55/217 (25%), Positives = 99/217 (45%), Gaps = 27/217 (12%)

Query: 107 QKISSAACGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRG----YEYVLEPS 162
           Q I+  ACG  F+++     ++   +  G  +  QLG +   K   R     Y+  L P 
Sbjct: 254 QPITKMACGAEFSMIMDCKGNL---YSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPR 310

Query: 163 PVSLPLDRPQETRVL--------QVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENE 214
            V++ +++ ++ ++L         V+CG  H+LVL  ++ VFS G   YG+ G    ++E
Sbjct: 311 RVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDE 370

Query: 215 IYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP 273
           +     R+ ++ DF G+   Q+  G   S  +++ G ++   WGA   +       ++  
Sbjct: 371 MVP---RLVKLFDFPGRGASQIYAGYTCSFAVSEVGGLFF--WGATNTS-----RESTMY 420

Query: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310
            K   DL G  +  +A  G   + V+AD     WG S
Sbjct: 421 PKAVQDLCGWRIRSLAC-GKSSIIVAADESTISWGPS 456



 Score = 50.1 bits (118), Expect = 4e-06
 Identities = 62/212 (29%), Positives = 90/212 (42%), Gaps = 39/212 (18%)

Query: 278 GDLAGVNVIQVATYGDCC---LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSG 334
           G LAGV V  V + G C    L ++ +G L+ WG +E  QL    D+ +V  PR +    
Sbjct: 143 GCLAGVRVRTVVS-GSCAAHSLLITTEGKLWSWGRNEKGQLGH-GDTKRVEAPRLIEGLS 200

Query: 335 VGKVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPE 393
              +  AACG      L   G VF +G   +G+ G      AVP   P  +     +N +
Sbjct: 201 HEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPS--PAQIM----YNGQ 254

Query: 394 IQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLG-------IGRLED-----QYFPWRV- 440
             ++++ CG      +  KG L+ +G    G LG       I R +      +  P RV 
Sbjct: 255 -PITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVA 313

Query: 441 -----TMPGE--PV------DVACGVDHMVTL 459
                T  G+  PV      DVACG +H + L
Sbjct: 314 IFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345


>gi|6912330 deafness locus associated putative guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 458

 Score = 80.5 bits (197), Expect = 3e-15
 Identities = 99/362 (27%), Positives = 145/362 (40%), Gaps = 63/362 (17%)

Query: 131 VWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLT 190
           ++  G N   QLG            E VL P  ++   D  +   V +++ G  HS V+T
Sbjct: 17  LFAWGANSYGQLGLGHK--------EDVLLPQQLN---DFCKPRSVRRITGGGGHSAVVT 65

Query: 191 DREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGE 250
           D   +F  G N  GQ G    E+  Y    +      F   + QVACG D ++ LT+ G+
Sbjct: 66  DGGDLFVCGLNKDGQLGLGHTEDIPYFTPCK----SLFGCPIQQVACGWDFTIMLTENGQ 121

Query: 251 VYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNS 310
           V SCG  + GQ G+ H            +L    V+ +A      +A +A G +F WG  
Sbjct: 122 VLSCGSNSFGQLGVPH-GPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGTG 180

Query: 311 EYLQLASVTDSTQVNVPRCLHFSGVGKVR-------QAAC---GGTGCAVLNGEGHVFVW 360
               LAS            L F+     R       +A C   G    A L   G V+VW
Sbjct: 181 ----LASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVW 236

Query: 361 GYGILGKGPNLVESA---VPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFV 417
           G    G+  N  E+A   VP+ I    F         +V+ I  G +H  A T  G++F 
Sbjct: 237 GSNKHGQLAN--EAAFLPVPQKIEAHCF------QNEKVTAIWSGWTHLVAQTETGKMFT 288

Query: 418 WGKNIRGCLGIGRLEDQYFPWRV--------------TMPGEP------VDVACGVDHMV 457
           WG+   G L  GR  + Y  W++              +MP  P       +V+CG +H +
Sbjct: 289 WGRADYGQL--GRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNL 346

Query: 458 TL 459
            +
Sbjct: 347 AI 348



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 97/374 (25%), Positives = 149/374 (39%), Gaps = 67/374 (17%)

Query: 122 SSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETRVLQVSC 181
           S+   D   ++  GLNKD QLG   +            E  P   P        + QV+C
Sbjct: 61  SAVVTDGGDLFVCGLNKDGQLGLGHT------------EDIPYFTPCKSLFGCPIQQVAC 108

Query: 182 GRAHSLVLTDREGVFSMGNNSYGQCG------RKVVENEIYSESHRVHRMQDFDGQVVQV 235
           G   +++LT+   V S G+NS+GQ G      R VV   I  E H+         +VV +
Sbjct: 109 GWDFTIMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAI--ELHK--------EKVVCI 158

Query: 236 ACGQDHSLFLTDKGEVYSCGWG--------ADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 287
           A G  H++  T  G V+  G G          GQT L  +     P+++ G L     + 
Sbjct: 159 AAGLRHAVAATASGIVFQWGTGLASCGRRLCPGQT-LPLFFTAKEPSRVTG-LENSKAMC 216

Query: 288 VATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCL--HFSGVGKVRQAACGG 345
           V    D   +++  G ++ WG++++ QLA+  ++  + VP+ +  H     KV     G 
Sbjct: 217 VLAGSDHSASLTDAGEVYVWGSNKHGQLAN--EAAFLPVPQKIEAHCFQNEKVTAIWSGW 274

Query: 346 TGCAVLNGEGHVFVWG---YGILGKGPNLVE-------------SAVPEMIPPTLFGLTE 389
           T        G +F WG   YG LG+     E             S  P  +P +   LT 
Sbjct: 275 THLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLT- 333

Query: 390 FNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--TMPGEPV 447
                  + + CG  H  A+   G  + WG N  G  G G   + + P  V   +    +
Sbjct: 334 -----GATEVSCGSEHNLAIIG-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGL 387

Query: 448 DVACGVDHMVTLAK 461
            V CG  H + L +
Sbjct: 388 LVGCGAGHSLALCQ 401


>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
          Length = 979

 Score = 71.2 bits (173), Expect = 2e-12
 Identities = 60/271 (22%), Positives = 112/271 (41%), Gaps = 47/271 (17%)

Query: 60  RVFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFT 119
           +++ +G  + G +GV     P               ++P+     L   +   +CG    
Sbjct: 446 QLYAFGSDYYGCMGVDKVAGPEV-------------LEPMQLNFFLSNPVEQVSCGDNHV 492

Query: 120 LLSSKTADVTKVWGMG----LNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQETR 175
           ++ ++  +V   WG G    L  DS+  ++  +K                  +D P+   
Sbjct: 493 VVLTRNKEVYS-WGCGEYGRLGLDSEEDYYTPQK------------------VDVPKALI 533

Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYG-----QCGRKVVENEIYSE-----SHRVHRM 225
           ++ V CG   + +LT    V + G N +      QC   ++ +E Y E     S  + + 
Sbjct: 534 IVAVQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQ 593

Query: 226 QDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNV 285
             F  ++  +A G+ H+  + ++G + + G    GQ G+G+Y        LGG L G  V
Sbjct: 594 LSFY-KIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQV 652

Query: 286 IQVATYGDCCLAVSADGGLFGWGNSEYLQLA 316
           I+V+   +  +A + D  +F WGN    +LA
Sbjct: 653 IRVSCGDEFTIAATDDNHIFAWGNGGNGRLA 683



 Score = 67.0 bits (162), Expect = 3e-11
 Identities = 70/276 (25%), Positives = 114/276 (41%), Gaps = 26/276 (9%)

Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227
           +++ Q   + QVSCG   ++ +TD   +++ G++ YG  G   V      E  +++    
Sbjct: 420 VEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFF-- 477

Query: 228 FDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQ 287
               V QV+CG +H + LT   EVYS G G  G+ GL       +P K+    A + ++ 
Sbjct: 478 LSNPVEQVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI-IVA 536

Query: 288 VATYGDCCLAVSADGGLFGWGNSEYLQL-------ASVTDSTQVNVPRCLHFS-----GV 335
           V    D    ++  G +   G +E+ +L         +       VP    F+       
Sbjct: 537 VQCGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSF 596

Query: 336 GKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPTLFGLTEFNP 392
            K+R  A G T  A ++  G +  +G    G LG G N  +     ++   L G      
Sbjct: 597 YKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG-NYKKRLGINLLGGPLGGK----- 650

Query: 393 EIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGI 428
             QV R+ CG     A T+   +F WG    G L +
Sbjct: 651 --QVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684



 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 58/202 (28%), Positives = 87/202 (43%), Gaps = 18/202 (8%)

Query: 271 SSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSE-----YLQLASVTDSTQVN 325
           S+P KL    +G +  QV         V+ +  L+ W N +     + QL    D     
Sbjct: 357 STPQKLDVIKSGCSARQVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGH-GDKASYR 415

Query: 326 VPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPP 382
            P+ +       +RQ +CG      +  EG ++ +G   YG +G    + + A PE++ P
Sbjct: 416 QPKHVEKLQGKAIRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMG----VDKVAGPEVLEP 471

Query: 383 TLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTM 442
                   NP  QVS   CG +H   LT   E++ WG    G LG+   ED Y P +V +
Sbjct: 472 MQLNFFLSNPVEQVS---CGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDV 528

Query: 443 PGEPVDVA--CGVDHMVTLAKS 462
           P   + VA  CG D    L +S
Sbjct: 529 PKALIIVAVQCGCDGTFLLTQS 550



 Score = 62.4 bits (150), Expect = 8e-10
 Identities = 74/274 (27%), Positives = 121/274 (44%), Gaps = 36/274 (13%)

Query: 178 QVSCGRAHSLVLTDREGVFSM-----GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQV 232
           QV  G  H  V+T  + +++      G   +GQ G    +   Y +   V ++Q   G+ 
Sbjct: 373 QVCAGNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHG--DKASYRQPKHVEKLQ---GKA 427

Query: 233 V-QVACGQDHSLFLTDKGEVYSCG---WGADGQTGLGHYNITSSPTKLGGDLAGVNVIQV 288
           + QV+CG D ++ +TD+G++Y+ G   +G  G   +    +   P +L   L+  N ++ 
Sbjct: 428 IRQVSCGDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVL-EPMQLNFFLS--NPVEQ 484

Query: 289 ATYGDCCLAV-SADGGLFGWGNSEY--LQLASVTD---STQVNVPRCLHFSGVGKVRQAA 342
            + GD  + V + +  ++ WG  EY  L L S  D     +V+VP+ L    V       
Sbjct: 485 VSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAV------Q 538

Query: 343 CGGTGCAVLNGEGHVFVWGYGILGK-GPN------LVESAVPEMIPPTLFGLTEFNPEIQ 395
           CG  G  +L   G V   G     K G N      +   A  E+   T F L +     +
Sbjct: 539 CGCDGTFLLTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYK 598

Query: 396 VSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIG 429
           +  I  G +H AA+  +G L  +G N  G LG+G
Sbjct: 599 IRTIAPGKTHTAAIDERGRLLTFGCNKCGQLGVG 632



 Score = 46.2 bits (108), Expect = 6e-05
 Identities = 49/214 (22%), Positives = 89/214 (41%), Gaps = 32/214 (14%)

Query: 57  RADRVFVWGFSFSGALGVPS---FVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAA 113
           R   V+ WG    G LG+ S   +  P     P+A                    I +  
Sbjct: 497 RNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI------------------IVAVQ 538

Query: 114 CGYGFTLLSSKTADVTKVWGMGLNKDSQLGFHRSRKDKTRGYEYVLEPSPVSLPLDRPQE 173
           CG   T L +++    KV   GLN+ ++LG ++          Y   P   S  L +   
Sbjct: 539 CGCDGTFLLTQSG---KVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLS 595

Query: 174 T-RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-- 230
             ++  ++ G+ H+  + +R  + + G N  GQ G   V N  Y +   ++ +    G  
Sbjct: 596 FYKIRTIAPGKTHTAAIDERGRLLTFGCNKCGQLG---VGN--YKKRLGINLLGGPLGGK 650

Query: 231 QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGL 264
           QV++V+CG + ++  TD   +++ G G +G+  +
Sbjct: 651 QVIRVSCGDEFTIAATDDNHIFAWGNGGNGRLAM 684


>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
          Length = 692

 Score = 63.5 bits (153), Expect = 4e-10
 Identities = 56/209 (26%), Positives = 87/209 (41%), Gaps = 26/209 (12%)

Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFD-GQVVQ 234
           ++QV+CG +H L L+    +F+ G    G+ G          ESH   +      GQ  Q
Sbjct: 445 MVQVACGASHVLALSTERELFAWGRGDSGRLGLGT------RESHSCPQQVPMPPGQEAQ 498

Query: 235 -VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSP------------TKLGG--- 278
            V CG D S+ LT  G+  +CG     + GL H ++   P            T LG    
Sbjct: 499 RVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPL 558

Query: 279 DLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKV 338
           D   +  I + T      AV+A G  + +G++++ QL + T        +     G+ K+
Sbjct: 559 DQEPLLSIDLGTAHSA--AVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGI-KM 615

Query: 339 RQAACGGTGCAVLNGEGHVFVWGYGILGK 367
              ACG      +  E  V+ WG G  G+
Sbjct: 616 AMVACGDAFTVAIGAESEVYSWGKGARGR 644



 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 76/312 (24%), Positives = 126/312 (40%), Gaps = 35/312 (11%)

Query: 160 EPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSES 219
           +P  +S  L+      +  V+CG   +  LTDR  + + G+ S G  G   + +   S+ 
Sbjct: 377 QPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTD--ISQP 434

Query: 220 HRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGD 279
             V  +  ++  +VQVACG  H L L+ + E+++ G G  G+ GLG     S P ++   
Sbjct: 435 TIVEALLGYE--MVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP 492

Query: 280 LAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLA------SVTDSTQVNVPRCLHFS 333
             G    +V    D  + ++  G     G++ + +L                V   L F+
Sbjct: 493 -PGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551

Query: 334 GVGK-------VRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESAVPEMIPPT 383
            +G        +     G    A +   G  + +G   +G LG        A     P  
Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRA-----PCK 606

Query: 384 LFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRV--- 440
           + GL      I+++ + CG +   A+  + E++ WGK  RG LG  R ED   P  V   
Sbjct: 607 VQGL----EGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLG-RRDEDAGLPRPVQLD 661

Query: 441 -TMPGEPVDVAC 451
            T P     V+C
Sbjct: 662 ETHPYTVTSVSC 673



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 56/198 (28%), Positives = 80/198 (40%), Gaps = 22/198 (11%)

Query: 274 TKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGW-------GNSEYLQLASVTDSTQVNV 326
           T L   +    V+QVA        V+  G L  W       G    L  A      Q  +
Sbjct: 323 TPLRLPMLNTEVVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLPGAVEQPQPQF-I 381

Query: 327 PRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG---ILGKGPNLVESAVPEMIPPT 383
            R L       ++  ACG    A L   G +  +G G    LG G +L + + P ++   
Sbjct: 382 SRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHG-SLTDISQPTIVEAL 440

Query: 384 LFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMP 443
           L          ++ ++ CG SH  AL+ + ELF WG+   G LG+G  E    P +V MP
Sbjct: 441 L--------GYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMP 492

Query: 444 --GEPVDVACGVDHMVTL 459
              E   V CG+D  + L
Sbjct: 493 PGQEAQRVVCGIDSSMIL 510



 Score = 51.6 bits (122), Expect = 1e-06
 Identities = 63/222 (28%), Positives = 94/222 (42%), Gaps = 29/222 (13%)

Query: 224 RMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGW-----GADGQTGLGHYNITSSPTKLGG 278
           R+   + +VVQVA G+     +T  G +    W     GA G + L        P  +  
Sbjct: 326 RLPMLNTEVVQVAAGRTQKAGVTRSGRLIL--WEAPPLGAGGGSLLPGAVEQPQPQFISR 383

Query: 279 DL---AGVNVIQVATYGDCCLAVSADGGL---FGWGNSEYLQLASVTDSTQVNVPRCLHF 332
            L   +GV +  VA  GD   A   D G+   FG G++  L   S+TD +Q  +   L  
Sbjct: 384 FLEGQSGVTIKHVAC-GDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEAL-- 440

Query: 333 SGVG-KVRQAACGGTGCAVLNGEGHVFVWGYGILGK-GPNLVES-AVPEMIPPTLFGLTE 389
             +G ++ Q ACG +    L+ E  +F WG G  G+ G    ES + P+ +P        
Sbjct: 441 --LGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVP-------- 490

Query: 390 FNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRL 431
             P  +  R+ CG+     LT  G+    G N    LG+  L
Sbjct: 491 MPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHL 532



 Score = 50.8 bits (120), Expect = 3e-06
 Identities = 52/209 (24%), Positives = 88/209 (42%), Gaps = 32/209 (15%)

Query: 61  VFVWGFSFSGALGVPSFVVPSSGPGPRAGARPRRRIQPVPYRLELDQKISSAACGYGFTL 120
           +F WG   SG LG+          G R      +++   P      Q+     CG   ++
Sbjct: 464 LFAWGRGDSGRLGL----------GTRESHSCPQQVPMPP-----GQEAQRVVCGIDSSM 508

Query: 121 LSSKTADVTKVWGMGLNKDSQLGF-HRSRKDKTRGYEYVLEPSPVSL----PLDRPQETR 175
           + +           G N+ ++LG  H S  ++   ++ V E    +L    PLD+     
Sbjct: 509 ILTVPGQAL---ACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEP--- 562

Query: 176 VLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDG-QVVQ 234
           +L +  G AHS  +T     ++ G+N +GQ G           S    ++Q  +G ++  
Sbjct: 563 LLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG-----SRAPCKVQGLEGIKMAM 617

Query: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTG 263
           VACG   ++ +  + EVYS G GA G+ G
Sbjct: 618 VACGDAFTVAIGAESEVYSWGKGARGRLG 646


>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 24/212 (11%)

Query: 157 YVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIY 216
           YV   +P   PL    E R  Q+  G  H+L+L     VFS G   +GQ G   +E E+ 
Sbjct: 143 YVSPRAPFYRPL--APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199

Query: 217 SESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL 276
            E   +  +Q     + +VA G  HS+ +++ G++Y  GW   GQ  L   N+       
Sbjct: 200 -EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED---- 252

Query: 277 GGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGV 335
                G  V + AT   +    V   GG      + ++ +           P  L     
Sbjct: 253 -----GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP--------FPALLDLPMG 299

Query: 336 GKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
               +A+CG    AV+   G ++ WG+G  G+
Sbjct: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 59/194 (30%), Positives = 79/194 (40%), Gaps = 22/194 (11%)

Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 293
           Q+  G +H+L L   G+V+S G G  GQ G G       P  L   L G+ + +VA  G 
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220

Query: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
             + VS  G ++ WG +E  QLA  T        R L   G    R+A         LN 
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265

Query: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413
           +G       G     P    +  P    P L  L   +  ++ S   CG  H A +T  G
Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319

Query: 414 ELFVWGKNIRGCLG 427
           EL+ WG    G LG
Sbjct: 320 ELYTWGWGKYGQLG 333



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)

Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271
           V+ +CG  H+  +T  GE+Y+ GWG  GQ  LGH + TS
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 3/89 (3%)

Query: 163 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 222
           P    LD P  +  ++ SCG  H+ V+T    +++ G   YGQ G +  +        RV
Sbjct: 289 PFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE--DTTSLDRPRRV 346

Query: 223 HRMQDFDGQVVQVACGQDHS-LFLTDKGE 250
               D   QV  V CG  ++ ++  +KG+
Sbjct: 347 EYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 16/46 (34%), Positives = 23/46 (50%)

Query: 392 PEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
           PE++  ++  G  H   L   G++F WG    G LG G LE +  P
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201


>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
          Length = 376

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 55/212 (25%), Positives = 86/212 (40%), Gaps = 24/212 (11%)

Query: 157 YVLEPSPVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIY 216
           YV   +P   PL    E R  Q+  G  H+L+L     VFS G   +GQ G   +E E+ 
Sbjct: 143 YVSPRAPFYRPL--APELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL- 199

Query: 217 SESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKL 276
            E   +  +Q     + +VA G  HS+ +++ G++Y  GW   GQ  L   N+       
Sbjct: 200 -EPRLLEALQGL--VMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAED---- 252

Query: 277 GGDLAGVNVIQVAT-YGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGV 335
                G  V + AT   +    V   GG      + ++ +           P  L     
Sbjct: 253 -----GETVAREATELNEDGSQVKRTGGAEDGAPAPFIAVQP--------FPALLDLPMG 299

Query: 336 GKVRQAACGGTGCAVLNGEGHVFVWGYGILGK 367
               +A+CG    AV+   G ++ WG+G  G+
Sbjct: 300 SDAVKASCGSRHTAVVTRTGELYTWGWGKYGQ 331



 Score = 57.0 bits (136), Expect = 4e-08
 Identities = 59/194 (30%), Positives = 79/194 (40%), Gaps = 22/194 (11%)

Query: 234 QVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGD 293
           Q+  G +H+L L   G+V+S G G  GQ G G       P  L   L G+ + +VA  G 
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEA-LQGLVMAEVAAGGW 220

Query: 294 CCLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
             + VS  G ++ WG +E  QLA  T        R L   G    R+A         LN 
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPT--------RNLAEDGETVAREAT-------ELNE 265

Query: 354 EGHVFVWGYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKG 413
           +G       G     P    +  P    P L  L   +  ++ S   CG  H A +T  G
Sbjct: 266 DGSQVKRTGGAEDGAPAPFIAVQPF---PALLDLPMGSDAVKAS---CGSRHTAVVTRTG 319

Query: 414 ELFVWGKNIRGCLG 427
           EL+ WG    G LG
Sbjct: 320 ELYTWGWGKYGQLG 333



 Score = 38.9 bits (89), Expect = 0.010
 Identities = 18/39 (46%), Positives = 25/39 (64%), Gaps = 2/39 (5%)

Query: 233 VQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITS 271
           V+ +CG  H+  +T  GE+Y+ GWG  GQ  LGH + TS
Sbjct: 303 VKASCGSRHTAVVTRTGELYTWGWGKYGQ--LGHEDTTS 339



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 25/89 (28%), Positives = 41/89 (46%), Gaps = 3/89 (3%)

Query: 163 PVSLPLDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRV 222
           P    LD P  +  ++ SCG  H+ V+T    +++ G   YGQ G +  +        RV
Sbjct: 289 PFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE--DTTSLDRPRRV 346

Query: 223 HRMQDFDGQVVQVACGQDHS-LFLTDKGE 250
               D   QV  V CG  ++ ++  +KG+
Sbjct: 347 EYFVDKQLQVKAVTCGPWNTYVYAVEKGK 375



 Score = 34.3 bits (77), Expect = 0.25
 Identities = 16/46 (34%), Positives = 23/46 (50%)

Query: 392 PEIQVSRIRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFP 437
           PE++  ++  G  H   L   G++F WG    G LG G LE +  P
Sbjct: 156 PELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEP 201


>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
          Length = 1353

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 47/171 (27%), Positives = 76/171 (44%), Gaps = 10/171 (5%)

Query: 190 TDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKG 249
           TD   V++ G+N+    G     ++ + E   +         + QV   + HS+FL+ KG
Sbjct: 139 TDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGI--YIKQVVLCKFHSVFLSQKG 196

Query: 250 EVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGN 309
           +VY+CG G  G+ G G       P  + G L G N  QVA   D  + ++ DG ++ +G 
Sbjct: 197 QVYTCGHGPGGRLGHGDEQTCLVPRLVEG-LNGHNCSQVAAAKDHTVVLTEDGCVYTFGL 255

Query: 310 SEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360
           + + QL  +   +  NVPR +         +   G T   V  G  H  +W
Sbjct: 256 NIFHQLGIIPPPSSCNVPRQIQ-------AKYLKGRTIIGVAAGRFHTVLW 299


>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
           sapiens]
          Length = 596

 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 53/194 (27%), Positives = 80/194 (41%), Gaps = 30/194 (15%)

Query: 195 VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYS 253
           VFS G+  +G+ GR   E       +    ++  +GQ V Q+ CG    L LT  G V++
Sbjct: 25  VFSWGDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 79

Query: 254 CGWGADGQTGLGHYNITS--SPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSE 311
             WG      LGH +      P  + G L G  ++ VA     CLAV   G ++ WG+++
Sbjct: 80  --WGKGDYFRLGHRSDVHVRKPQVVEG-LRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 136

Query: 312 YLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNL 371
           + Q  + T +T    P  +      K+   ACG +         H   W           
Sbjct: 137 HGQQGNGT-TTVNRKPTLVQGLEGQKIMCVACGSS---------HSVAW---------TT 177

Query: 372 VESAVPEMIPPTLF 385
           V+ A P +  P LF
Sbjct: 178 VDVATPSVHEPVLF 191



 Score = 50.4 bits (119), Expect = 3e-06
 Identities = 39/126 (30%), Positives = 58/126 (46%), Gaps = 13/126 (10%)

Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227
           ++R     V Q+ CG    L LT    V++ G   Y + G +       S+ H V + Q 
Sbjct: 50  IERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHR-------SDVH-VRKPQV 101

Query: 228 FDG----QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283
            +G    ++V VA G  H L + D G+VY+ G    GQ G G   +   PT + G L G 
Sbjct: 102 VEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQG-LEGQ 160

Query: 284 NVIQVA 289
            ++ VA
Sbjct: 161 KIMCVA 166



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 41/156 (26%), Positives = 64/156 (41%), Gaps = 9/156 (5%)

Query: 304 LFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYG 363
           +F WG+ ++ +L     S   N+P+ +       V Q  CG      L   G V+ WG G
Sbjct: 25  VFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83

Query: 364 ILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGKNIR 423
              +  +   S V    P  + GL       ++  +  G  H  A+ + G+++ WG N  
Sbjct: 84  DYFRLGH--RSDVHVRKPQVVEGLRGK----KIVHVAVGAQHCLAVMDSGQVYAWGDNDH 137

Query: 424 GCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 457
           G  G G       P  V  + G+ +  VACG  H V
Sbjct: 138 GQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSV 173



 Score = 29.6 bits (65), Expect = 6.1
 Identities = 24/68 (35%), Positives = 28/68 (41%), Gaps = 8/68 (11%)

Query: 354 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412
           E  VF WG G  GK G    E      IP  +  L        V +I CG     ALT  
Sbjct: 22  ESLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 74

Query: 413 GELFVWGK 420
           G ++ WGK
Sbjct: 75  GVVWTWGK 82


>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
           sapiens]
          Length = 1102

 Score = 52.8 bits (125), Expect = 7e-07
 Identities = 50/193 (25%), Positives = 80/193 (41%), Gaps = 28/193 (14%)

Query: 195 VFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQ-VVQVACGQDHSLFLTDKGEVYS 253
           VFS G+  +G+ GR   E       +    ++  +GQ V Q+ CG    L LT  G V++
Sbjct: 727 VFSWGDGDFGKLGRGGSEG-----CNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWT 781

Query: 254 CGWGADGQTGLGHYN-ITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEY 312
             WG      LGH + +     ++   L G  ++ VA     CLAV   G ++ WG++++
Sbjct: 782 --WGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDH 839

Query: 313 LQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWGYGILGKGPNLV 372
            Q  + T +T    P  +      K+   ACG +         H   W           +
Sbjct: 840 GQQGNGT-TTVNRKPMLVQGLEGQKIMCVACGSS---------HSVAW---------TTM 880

Query: 373 ESAVPEMIPPTLF 385
           + A P +  P LF
Sbjct: 881 DVATPSVHEPVLF 893



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 38/126 (30%), Positives = 58/126 (46%), Gaps = 13/126 (10%)

Query: 168 LDRPQETRVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQD 227
           ++R     V Q+ CG    L LT    V++ G   Y + G +       S+ H V ++Q 
Sbjct: 752 IERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHR-------SDVH-VRKLQV 803

Query: 228 FDG----QVVQVACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGV 283
            +G    ++V VA G  H L + D G+VY+ G    GQ G G   +   P  + G L G 
Sbjct: 804 VEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQG-LEGQ 862

Query: 284 NVIQVA 289
            ++ VA
Sbjct: 863 KIMCVA 868



 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 41/159 (25%), Positives = 66/159 (41%), Gaps = 10/159 (6%)

Query: 302 GGL-FGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 360
           GGL F WG+ ++ +L     S   N+P+ +       V Q  CG      L   G V+ W
Sbjct: 724 GGLVFSWGDGDFGKLGR-GGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTW 782

Query: 361 GYGILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNKGELFVWGK 420
           G G   +  +  +  V ++       + E     ++  +  G  H  A+ + G+++ WG 
Sbjct: 783 GKGDYFRLGHRSDVHVRKL------QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGD 836

Query: 421 NIRGCLGIGRLEDQYFPWRVT-MPGEPV-DVACGVDHMV 457
           N  G  G G       P  V  + G+ +  VACG  H V
Sbjct: 837 NDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSV 875



 Score = 30.4 bits (67), Expect = 3.6
 Identities = 50/188 (26%), Positives = 64/188 (34%), Gaps = 30/188 (15%)

Query: 247 DKGEVYSCGWGADGQTGLGHYN--------ITSSPTKLGGDLAGV--NVIQVATYGDCC- 295
           D+GE  + G  ADG     +YN           +P    G  A     +     +GD C 
Sbjct: 613 DEGE--AAGAAADGVAAYSNYNNGHRKFLATAQNPADEPGPGAPAPQELGAAGKHGDLCE 670

Query: 296 --LAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNG 353
             L  SA G    W +        +     V       +   GKV       T C +   
Sbjct: 671 VSLTSSAQGEAT-WPHPVLFHFGEIIQDKSVGN---WEYISTGKVSDNYALLTKCEM--- 723

Query: 354 EGHVFVWGYGILGK-GPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSHFAALTNK 412
            G VF WG G  GK G    E      IP  +  L        V +I CG     ALT  
Sbjct: 724 GGLVFSWGDGDFGKLGRGGSEGC---NIPQNIERLNGQG----VCQIECGAQFLLALTKS 776

Query: 413 GELFVWGK 420
           G ++ WGK
Sbjct: 777 GVVWTWGK 784


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,802,236
Number of Sequences: 37866
Number of extensions: 897931
Number of successful extensions: 3050
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 38
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2450
Number of HSP's gapped (non-prelim): 189
length of query: 464
length of database: 18,247,518
effective HSP length: 106
effective length of query: 358
effective length of database: 14,233,722
effective search space: 5095672476
effective search space used: 5095672476
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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