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Search of human proteins with 13540549
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|13540549 potassium voltage-gated channel, subfamily H,
member 6 isoform 1 [Homo sapiens]
(994 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|13540549 potassium voltage-gated channel, subfamily H, member... 2026 0.0
gi|27886651 potassium voltage-gated channel, subfamily H, member... 1779 0.0
gi|4557729 voltage-gated potassium channel, subfamily H, member ... 944 0.0
gi|27886653 potassium voltage-gated channel, subfamily H, member... 918 0.0
gi|26051273 voltage-gated potassium channel, subfamily H, member... 891 0.0
gi|26051271 voltage-gated potassium channel, subfamily H, member... 803 0.0
gi|27886665 potassium voltage-gated channel, subfamily H, member... 674 0.0
gi|27886667 potassium voltage-gated channel, subfamily H, member... 598 e-171
gi|6912446 potassium voltage-gated channel, subfamily H, member ... 593 e-169
gi|4504831 potassium voltage-gated channel, subfamily H, member ... 553 e-157
gi|27437001 potassium voltage-gated channel, subfamily H, member... 543 e-154
gi|22024390 potassium voltage-gated channel, subfamily H, member... 538 e-153
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re... 536 e-152
gi|27886648 potassium voltage-gated channel, subfamily H, member... 482 e-136
gi|27886646 potassium voltage-gated channel, subfamily H, member... 478 e-135
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p... 186 1e-46
gi|156071470 hyperpolarization activated cyclic nucleotide-gated... 180 5e-45
gi|116325989 hyperpolarization activated cyclic nucleotide-gated... 177 4e-44
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ... 174 4e-43
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [... 162 1e-39
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho... 162 1e-39
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [... 157 6e-38
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H... 157 6e-38
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens] 149 1e-35
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens] 137 5e-32
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H... 94 8e-19
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens] 89 3e-17
gi|205361107 potassium channel, subfamily K, member 17 isoform 2... 43 0.002
gi|17025230 potassium channel, subfamily K, member 17 isoform 1 ... 43 0.002
gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [H... 40 0.008
>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
isoform 1 [Homo sapiens]
Length = 994
Score = 2026 bits (5249), Expect = 0.0
Identities = 994/994 (100%), Positives = 994/994 (100%)
Query: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM
Sbjct: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
Query: 61 QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG
Sbjct: 61 QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
Query: 121 AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ 180
AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ
Sbjct: 121 AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ 180
Query: 181 IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ 240
IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ
Sbjct: 181 IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ 240
Query: 241 APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL 300
APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL
Sbjct: 241 APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL 300
Query: 301 TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI 360
TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI
Sbjct: 301 TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI 360
Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY 420
FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY 420
Query: 421 AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFG 480
AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFG
Sbjct: 421 AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFG 480
Query: 481 NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ 540
NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ
Sbjct: 481 NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ 540
Query: 541 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK 600
IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK
Sbjct: 541 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK 600
Query: 601 GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP 660
GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP
Sbjct: 601 GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP 660
Query: 661 VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG 720
VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG
Sbjct: 661 VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG 720
Query: 721 LHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHP 780
LHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHP
Sbjct: 721 LHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHP 780
Query: 781 DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV 840
DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV
Sbjct: 781 DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV 840
Query: 841 SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS 900
SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS
Sbjct: 841 SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS 900
Query: 901 YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG 960
YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG
Sbjct: 901 YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG 960
Query: 961 PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH 994
PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH
Sbjct: 961 PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH 994
>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
isoform 2 [Homo sapiens]
Length = 905
Score = 1779 bits (4607), Expect = 0.0
Identities = 901/994 (90%), Positives = 902/994 (90%), Gaps = 89/994 (8%)
Query: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM
Sbjct: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
Query: 61 QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG
Sbjct: 61 QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
Query: 121 AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ 180
AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ
Sbjct: 121 AVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQ 180
Query: 181 IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ 240
IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ
Sbjct: 181 IPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQ 240
Query: 241 APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL 300
APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL
Sbjct: 241 APRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPL 300
Query: 301 TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI 360
TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI
Sbjct: 301 TVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLI 360
Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY 420
FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH------- 413
Query: 421 AIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFG 480
WL + SLTSVGFG
Sbjct: 414 ---------------WLACI-------------------------------CSLTSVGFG 427
Query: 481 NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ 540
NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ
Sbjct: 428 NVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQ 487
Query: 541 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK 600
IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK
Sbjct: 488 IPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGK 547
Query: 601 GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP 660
GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP
Sbjct: 548 GCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEP 607
Query: 661 VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG 720
VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG
Sbjct: 608 VSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGG 667
Query: 721 LHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYSLLGPGSQNSMGAGPCAPGHP 780
LHSSPRQAPGSQDHQGFFLSDNQS
Sbjct: 668 LHSSPRQAPGSQDHQGFFLSDNQS------------------------------------ 691
Query: 781 DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV 840
DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV
Sbjct: 692 DAAPPLSISDASGLWPELLQEMPPRHSPQSPQEDPDCWPLKLGSRLEQLQAQMNRLESRV 751
Query: 841 SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS 900
SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS
Sbjct: 752 SSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPS 811
Query: 901 YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG 960
YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG
Sbjct: 812 YGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICG 871
Query: 961 PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH 994
PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH
Sbjct: 872 PCFSSLPEHLGSVPKQLDFQRHGSDPGFAGSWGH 905
>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
isoform a [Homo sapiens]
Length = 1159
Score = 944 bits (2441), Expect = 0.0
Identities = 537/888 (60%), Positives = 608/888 (68%), Gaps = 129/888 (14%)
Query: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233
+YRTIS+IPQ TLNFV+ + +S T++ EIIAP K+ ERT NVTEKVTQVLSLGADV
Sbjct: 326 RYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP-KIKERTHNVTEKVTQVLSLGADV 384
Query: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA- 292
LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLL + +E
Sbjct: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
Query: 293 CSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVA 352
C Y C PL VVDLIVDIMF+VDI+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVA
Sbjct: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
Query: 353 AIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412
AIPFDLLIF +GS+E LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA
Sbjct: 505 AIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 561
Query: 413 HWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFS 472
HWLACIWYAIGN+E+P+++ +IGWL +LG Q+GK YN S GPS++DKYVTALYFTFS
Sbjct: 562 HWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSG-LGGPSIKDKYVTALYFTFS 620
Query: 473 SLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 532
SLTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV
Sbjct: 621 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 680
Query: 533 KEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHC 592
+EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC
Sbjct: 681 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 740
Query: 593 PAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILG 652
F GA KGCLRALA+KFKTTHAPPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILG
Sbjct: 741 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
Query: 653 KNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTF 712
KNDIFGEP++L+A+PGKS+ DVRALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TF
Sbjct: 801 KNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITF 860
Query: 713 NLRDAAGGLHSSPRQAPGSQDHQGFF---------------LSDNQSGSPHELGP----- 752
NLRD + +PGS + +G F Q G LGP
Sbjct: 861 NLRDT-----NMIPGSPGSTELEGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGA 915
Query: 753 -------------QFPSKGYSL------LGPGSQNS-----MGAGPCAPGHPDAAPPL-- 786
+ PS G S GPG +S + P PG P PL
Sbjct: 916 GPSSRGRPGGPWGESPSSGPSSPESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLME 975
Query: 787 -----------------SISDASGLWPE----LLQEMPPRHSP-----QSPQEDPDCWPL 820
+S+ W + QE+P +P P P P
Sbjct: 976 DCEKSSDTCNPLSGAFSGVSNIFSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPR 1035
Query: 821 -KLGSRLEQLQAQMNRLESRVSSDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIAS 879
+ SRL+ LQ Q+NRLE+R+S+D++ +LQLLQ+ M L PA + A
Sbjct: 1036 GDVESRLDALQRQLNRLETRLSADMATVLQLLQRQM-------TLVPPAYS-------AV 1081
Query: 880 ETTSPGPRLPQGFLPPAQTPSYGDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPE 939
T PGP LP + P+ LD S + + L P + + E
Sbjct: 1082 TTPGPGPTSTSPLLPVSPLPTL-TLDSLSQVSQ----------FMACEELPPGAPELPQE 1130
Query: 940 GLWPPLASPLHPLEVQGLICGPCFSSLPEHLGSVPKQLDFQRHGSDPG 987
G P L SLP LG++ Q RHGSDPG
Sbjct: 1131 G-------PTRRL------------SLPGQLGALTSQ-PLHRHGSDPG 1158
Score = 224 bits (570), Expect = 4e-58
Identities = 106/130 (81%), Positives = 117/130 (90%)
Query: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
MPVRRGHVAPQNT+LDTIIRKFEGQSRKF+IANA++ENCA+IYCNDGFCEL GYSR EVM
Sbjct: 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
Query: 61 QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
Q+PCTCDFL GP T A +++AQALLGAEE KV+I +YRKD S F CLVDVVPVKNEDG
Sbjct: 61 QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
Query: 121 AVIMFILNFE 130
AVIMFILNFE
Sbjct: 121 AVIMFILNFE 130
>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
isoform 1 [Homo sapiens]
Length = 1196
Score = 918 bits (2373), Expect = 0.0
Identities = 450/542 (83%), Positives = 492/542 (90%)
Query: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233
KY TI++IPQ TLNF E EK SS + + I KV +RT NVTEKVTQVLSLGADV
Sbjct: 325 KYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADV 384
Query: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGAC 293
LPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL+D++E +R C
Sbjct: 385 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 444
Query: 294 SYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAA 353
Y+CSPL VVDLIVDIMF++DI+INFRTTYVN N+EVVS P +IA+HYFKGWFLIDMVAA
Sbjct: 445 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 504
Query: 354 IPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH 413
IPFDLLIF +GSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAH
Sbjct: 505 IPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAH 564
Query: 414 WLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSS 473
WLACIWYAIGNVERPYL KIGWLDSLG Q+GKRYN SD +SGPS++DKYVTALYFTFSS
Sbjct: 565 WLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSS 624
Query: 474 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 533
LTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH QMLRVK
Sbjct: 625 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVK 684
Query: 534 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 593
EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN VLKGFPECLQADICLHL++ LLQ+C
Sbjct: 685 EFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCK 744
Query: 594 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 653
AF GA KGCLRALA+KFKTTHAPPGDTLVH GDVL+ LYF+SRGSIEIL+DD+VVAILGK
Sbjct: 745 AFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGK 804
Query: 654 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 713
NDIFGE V L+A+PGKS+ADVRALTYCDLHKIQR DLLEVLDMYP F++ F + LE+TFN
Sbjct: 805 NDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFN 864
Query: 714 LR 715
LR
Sbjct: 865 LR 866
Score = 194 bits (492), Expect = 5e-49
Identities = 85/130 (65%), Positives = 111/130 (85%)
Query: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
MPVRRGHVAPQNT+L TIIRKFEGQ++KF+IANA+++NCAIIYCNDGFCE+ G+SR +VM
Sbjct: 1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60
Query: 61 QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
Q+PCTCDFL GP T ++++AQALLG+EE KV++ YY K+ S+F C ++PVKN++G
Sbjct: 61 QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
Query: 121 AVIMFILNFE 130
+MFI+NFE
Sbjct: 121 VAMMFIINFE 130
>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
isoform c [Homo sapiens]
Length = 819
Score = 891 bits (2302), Expect = 0.0
Identities = 512/866 (59%), Positives = 580/866 (66%), Gaps = 129/866 (14%)
Query: 197 RSSSTTEIEIIAPHKVVERTQNVTEKVTQ-VLSLGADVLPEYKLQAPRIHRWTILHYSPF 255
++S T + A V R ++ V Q VLSLGADVLPEYKLQAPRIHRWTILHYSPF
Sbjct: 7 KASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPF 66
Query: 256 KAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA-CSYTCSPLTVVDLIVDIMFVVD 314
KAVWDWLILLLVIYTAVFTPYSAAFLL + +E C Y C PL VVDLIVDIMF+VD
Sbjct: 67 KAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVD 126
Query: 315 IVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGL 374
I+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVAAIPFDLLIF +GS+E LIGL
Sbjct: 127 ILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSGSEE---LIGL 183
Query: 375 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKI 434
LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGN+E+P+++ +I
Sbjct: 184 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 243
Query: 435 GWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSI 494
GWL +LG Q+GK YN S GPS++DKYVTALYFTFSSLTSVGFGNVSPNTNSEK+FSI
Sbjct: 244 GWLHNLGDQIGKPYNSSG-LGGPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSI 302
Query: 495 CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQ 554
CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV+EFIRFHQIPNPLRQRLEEYFQ
Sbjct: 303 CVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQ 362
Query: 555 HAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTH 614
HAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC F GA KGCLRALA+KFKTTH
Sbjct: 363 HAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKFKTTH 422
Query: 615 APPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADV 674
APPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILGKNDIFGEP++L+A+PGKS+ DV
Sbjct: 423 APPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKSNGDV 482
Query: 675 RALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFNLRDAAGGLHSSPRQAPGSQDH 734
RALTYCDLHKI R DLLEVLDMYP F++ FWS LE+TFNLRD + +PGS +
Sbjct: 483 RALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLRDT-----NMIPGSPGSTEL 537
Query: 735 QGFF---------------LSDNQSGSPHELGP------------------QFPSKGYSL 761
+G F Q G LGP + PS G S
Sbjct: 538 EGGFSRQRKRKLSFRRRTDKDTEQPGEVSALGPGRAGAGPSSRGRPGGPWGESPSSGPSS 597
Query: 762 ------LGPGSQNS-----MGAGPCAPGHPDAAPPL-------------------SISDA 791
GPG +S + P PG P PL +S+
Sbjct: 598 PESSEDEGPGRSSSPLRLVPFSSPRPPGEPPGGEPLMEDCEKSSDTCNPLSGAFSGVSNI 657
Query: 792 SGLWPE----LLQEMPPRHSP-----QSPQEDPDCWPL-KLGSRLEQLQAQMNRLESRVS 841
W + QE+P +P P P P + SRL+ LQ Q+NRLE+R+S
Sbjct: 658 FSFWGDSRGRQYQELPRCPAPTPSLLNIPLSSPGRRPRGDVESRLDALQRQLNRLETRLS 717
Query: 842 SDLSRILQLLQKPMPQGHASYILEAPASNDLALVPIASETTSPGPRLPQGFLPPAQTPSY 901
+D++ +LQLLQ+ M L PA + A T PGP LP + P+
Sbjct: 718 ADMATVLQLLQRQM-------TLVPPAYS-------AVTTPGPGPTSTSPLLPVSPLPTL 763
Query: 902 GDLDDCSPKHRNSSPRMPHLAVATDKTLAPSSEQEQPEGLWPPLASPLHPLEVQGLICGP 961
LD S + + L P + + EG P L
Sbjct: 764 -TLDSLSQVSQ----------FMACEELPPGAPELPQEG-------PTRRL--------- 796
Query: 962 CFSSLPEHLGSVPKQLDFQRHGSDPG 987
SLP LG++ Q RHGSDPG
Sbjct: 797 ---SLPGQLGALTSQ-PLHRHGSDPG 818
>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
isoform b [Homo sapiens]
Length = 888
Score = 803 bits (2074), Expect = 0.0
Identities = 402/480 (83%), Positives = 434/480 (90%), Gaps = 6/480 (1%)
Query: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233
+YRTIS+IPQ TLNFV+ + +S T++ EIIAP K+ ERT NVTEKVTQVLSLGADV
Sbjct: 326 RYRTISKIPQITLNFVDLKGDPFLASPTSDREIIAP-KIKERTHNVTEKVTQVLSLGADV 384
Query: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGA- 292
LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLL + +E
Sbjct: 385 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATE 444
Query: 293 CSYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVA 352
C Y C PL VVDLIVDIMF+VDI+INFRTTYVN N+EVVSHP RIAVHYFKGWFLIDMVA
Sbjct: 445 CGYACQPLAVVDLIVDIMFIVDILINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVA 504
Query: 353 AIPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412
AIPFDLLIF +GS+E LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA
Sbjct: 505 AIPFDLLIFGSGSEE---LIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 561
Query: 413 HWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFS 472
HWLACIWYAIGN+E+P+++ +IGWL +LG Q+GK YN S GPS++DKYVTALYFTFS
Sbjct: 562 HWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSG-LGGPSIKDKYVTALYFTFS 620
Query: 473 SLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 532
SLTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV
Sbjct: 621 SLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRV 680
Query: 533 KEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHC 592
+EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL+R+LLQHC
Sbjct: 681 REFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHC 740
Query: 593 PAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILG 652
F GA KGCLRALA+KFKTTHAPPGDTLVH GD+L+ LYFISRGSIEILR DVVVAILG
Sbjct: 741 KPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILG 800
Score = 224 bits (570), Expect = 4e-58
Identities = 106/130 (81%), Positives = 117/130 (90%)
Query: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
MPVRRGHVAPQNT+LDTIIRKFEGQSRKF+IANA++ENCA+IYCNDGFCEL GYSR EVM
Sbjct: 1 MPVRRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVM 60
Query: 61 QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
Q+PCTCDFL GP T A +++AQALLGAEE KV+I +YRKD S F CLVDVVPVKNEDG
Sbjct: 61 QRPCTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDG 120
Query: 121 AVIMFILNFE 130
AVIMFILNFE
Sbjct: 121 AVIMFILNFE 130
>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
isoform 2 [Homo sapiens]
Length = 732
Score = 674 bits (1738), Expect = 0.0
Identities = 331/395 (83%), Positives = 358/395 (90%)
Query: 174 KYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADV 233
KY TI++IPQ TLNF E EK SS + + I KV +RT NVTEKVTQVLSLGADV
Sbjct: 318 KYSTINKIPQLTLNFSEVKTEKKNSSPPSSDKTIIAPKVKDRTHNVTEKVTQVLSLGADV 377
Query: 234 LPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGAC 293
LPEYKLQ PRI+++TILHYSPFKAVWDWLILLLVIYTA+FTPYSAAFLL+D++E +R C
Sbjct: 378 LPEYKLQTPRINKFTILHYSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRREC 437
Query: 294 SYTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAA 353
Y+CSPL VVDLIVDIMF++DI+INFRTTYVN N+EVVS P +IA+HYFKGWFLIDMVAA
Sbjct: 438 GYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAA 497
Query: 354 IPFDLLIFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAH 413
IPFDLLIF +GSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVL LLMC FALIAH
Sbjct: 498 IPFDLLIFGSGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLMLLMCIFALIAH 557
Query: 414 WLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSS 473
WLACIWYAIGNVERPYL KIGWLDSLG Q+GKRYN SD +SGPS++DKYVTALYFTFSS
Sbjct: 558 WLACIWYAIGNVERPYLTDKIGWLDSLGQQIGKRYNDSDSSSGPSIKDKYVTALYFTFSS 617
Query: 474 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 533
LTSVGFGNVSPNTNSEK+FSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYH QMLRVK
Sbjct: 618 LTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVK 677
Query: 534 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAV 568
EFIRFHQIPNPLRQRLEEYFQHAW+YTNGIDMN V
Sbjct: 678 EFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMV 712
Score = 194 bits (492), Expect = 5e-49
Identities = 85/130 (65%), Positives = 111/130 (85%)
Query: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVM 60
MPVRRGHVAPQNT+L TIIRKFEGQ++KF+IANA+++NCAIIYCNDGFCE+ G+SR +VM
Sbjct: 1 MPVRRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVM 60
Query: 61 QQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDG 120
Q+PCTCDFL GP T ++++AQALLG+EE KV++ YY K+ S+F C ++PVKN++G
Sbjct: 61 QKPCTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEG 120
Query: 121 AVIMFILNFE 130
+MFI+NFE
Sbjct: 121 VAMMFIINFE 130
>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
[Homo sapiens]
Length = 1107
Score = 598 bits (1543), Expect = e-171
Identities = 312/722 (43%), Positives = 456/722 (63%), Gaps = 53/722 (7%)
Query: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQM-ENCAIIYCNDGFCELFGYSRVEV 59
MPV +G +APQNT+LDTI +F+G F++ANAQ+ + I+YC+DGFCEL G++R EV
Sbjct: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEV 60
Query: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
MQ+ C+C FL G T + ++ ++L E K +I++Y+K+ S F CL+D+VP+KNE
Sbjct: 61 MQKSCSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEK 120
Query: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
G V++F+ +F+D+ K + + + GR + T
Sbjct: 121 GDVVLFLASFKDITDTKVKITPEDKKEDKVK--------------------GRSRAGT-- 158
Query: 180 QIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKL 239
+ + R S + I+ H ++R + K+ + + PEYK+
Sbjct: 159 ------------HFDSARRRSRAVLYHISGH--LQRREKNKLKINNNVFVDKPAFPEYKV 204
Query: 240 QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSP 299
+ ++ +LH+S FKA WDWLILL Y AV PY+ F+ +D + R
Sbjct: 205 SDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRST------- 257
Query: 300 LTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL 359
TV D+ V+I+F++DI++NFRTTYV+ + +V+ R I +HY WF+ID++AA+PFDLL
Sbjct: 258 -TVSDIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHYVTTWFIIDLIAALPFDLL 316
Query: 360 IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIW 419
+ +L+ LLKT RLLRL+R+ +KLDRYS++ VL LLM FAL+AHW+ACIW
Sbjct: 317 Y--AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIVLTLLMSMFALLAHWMACIW 374
Query: 420 YAIGNVERP---YLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTS 476
Y IG +ER L+ ++GWL LG +L Y G++ GPS++ Y+ ALYFT SSLTS
Sbjct: 375 YVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAALYFTLSSLTS 434
Query: 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 536
VGFGNVS NT++EK+FSIC MLIG+LM+A +FGNV+AIIQR+YS + YHT+ +K+FI
Sbjct: 435 VGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHTRTKDLKDFI 494
Query: 537 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 596
R H +P L+QR+ EYFQ WS NGID N +LK FP+ L++DI +HL++ +LQ F
Sbjct: 495 RVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKEILQ-LSLFE 553
Query: 597 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDI 656
A +GCLR+L++ KT+ PG+ L+ GD L +YF+ GS+E+L+D +V+AILGK D+
Sbjct: 554 CASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMVLAILGKGDL 613
Query: 657 FGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKL--EVTFNL 714
G +S+ Q K++ADV+ALTYCDL I L EVLD+YP +A F + ++T+NL
Sbjct: 614 IGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVEDIQHDLTYNL 673
Query: 715 RD 716
R+
Sbjct: 674 RE 675
>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
[Homo sapiens]
Length = 1017
Score = 593 bits (1529), Expect = e-169
Identities = 362/845 (42%), Positives = 489/845 (57%), Gaps = 79/845 (9%)
Query: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQ-MENCAIIYCNDGFCELFGYSRVEV 59
MPV +G +APQNT+LDTI +F+G FL+ANAQ I+YC+DGFCEL GY R EV
Sbjct: 1 MPVMKGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEV 60
Query: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
MQ+ C+C FL GP T A+ RL +AL G +E + +I +YRKD S+F CL+D++P+KNE
Sbjct: 61 MQKTCSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEM 120
Query: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
G V++F+ +F+D+ Q G PG GP GRG +
Sbjct: 121 GEVVLFLFSFKDITQ-------------------------SGSPG-LGPQGGRGDSNHEN 154
Query: 180 QIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKL 239
+ + + R S T + + H R Q + V V PEYK+
Sbjct: 155 SLGR---RGATWKFRSARRRSRTVLHRLTGH-FGRRGQGGMKANNNVFEPKPSV-PEYKV 209
Query: 240 QAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSP 299
+ R +LHYS KA+WD LILL Y AV PY+ F S D++ T
Sbjct: 210 ASVGGSRCLLLHYSVSKAIWDGLILLATFYVAVTVPYNVCF--SGDDDT-----PITSRH 262
Query: 300 LTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL 359
V D+ V+++F++DI++NFRTTYV+ + +V+S PR I +HY WF ID++AA+PFDLL
Sbjct: 263 TLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIGLHYLATWFFIDLIAALPFDLL 322
Query: 360 -IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI 418
IF T+L+ LLKT RLLRL+R+ +KL+RYS+ A VL LLM FAL+AHW+ACI
Sbjct: 323 YIFNI---TVTSLVHLLKTVRLLRLLRLLQKLERYSQCSAVVLTLLMSVFALLAHWMACI 379
Query: 419 WYAIGNVERPY---LEHKIGWLDSLGVQLGKRY-NGSDPASGPSVQDKYVTALYFTFSSL 474
WY IG E L IGWL LG +L Y NGS GPS + Y+ ALYFT SSL
Sbjct: 380 WYVIGRREMEANDPLLWDIGWLHELGKRLEVPYVNGS--VGGPSRRSAYIAALYFTLSSL 437
Query: 475 TSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKE 534
TSVGFGNV NT++EK+FSIC MLIG+LM+A +FGNV+AIIQR+YS + YH++M +K+
Sbjct: 438 TSVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKD 497
Query: 535 FIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPA 594
FIR H++P PL+QR+ EYFQ W+ +GID N +L+ FP+ L+ADI +HL+R +LQ P
Sbjct: 498 FIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREILQ-LPL 556
Query: 595 FSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKN 654
F A +GCLRAL++ KT+ PG+ L+ GD L Y++ GS+E+LRD++V+AILGK
Sbjct: 557 FGAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKG 616
Query: 655 DIFGEPV-------SLHAQPG---KSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESF 704
D+ G + L A P K+SADV+ALTYC L ++ L EVL +YP + +F
Sbjct: 617 DLIGADIPEPGQEPGLGADPNFVLKTSADVKALTYCGLQQLSSRGLAEVLRLYPEYGAAF 676
Query: 705 WSKL--EVTFNLRDAA--GGLHSSPRQAPGSQDHQGFFLSDNQSGSPHELGPQFPSKGYS 760
+ L ++TFNLR + GL R SQ S + P S
Sbjct: 677 RAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLP------------S 724
Query: 761 LLGPGSQNSMGAGPCAPGHPDAAPPLSISDASGLWPELL-QEMPPRHS-PQSPQEDPDCW 818
+ S G GP P P P LS + G LL +E+PP + SP P
Sbjct: 725 ITEAESGAEPGGGP-RPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLS 783
Query: 819 PLKLG 823
P G
Sbjct: 784 PALAG 788
>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
isoform 2 [Homo sapiens]
Length = 962
Score = 553 bits (1424), Expect = e-157
Identities = 297/724 (41%), Positives = 438/724 (60%), Gaps = 67/724 (9%)
Query: 4 RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63
RRG VAPQNT+L+ I+R+ F++ NAQ+ + I+Y NDGFC+L GY R EVMQ+
Sbjct: 7 RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
Query: 64 CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123
TC F+ G T + ++ Q E +IL Y+K+ + V + P++NE V+
Sbjct: 65 STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
Query: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183
+F+ F D+ S G GK+
Sbjct: 125 LFLCTFSDITAFKQPIEDDSCK-------------------------GWGKFA------- 152
Query: 184 FTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTE--KVTQVLSLGADVLPEYKLQA 241
L + +SS ++ +AP V++ +NV + ++ +VL LG+D+LP+YK +A
Sbjct: 153 --------RLTRALTSSRGVLQQLAPS--VQKGENVHKHSRLAEVLQLGSDILPQYKQEA 202
Query: 242 PRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLT 301
P+ ILHY FK WDW+IL+L YTA+ PY+ +F ++R+ ++
Sbjct: 203 PKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSF------KTRQNNVAWL----- 251
Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-I 360
VVD IVD++F+VDIV+NF TT+V EV+S P+ I ++Y K WF+ID+++ +P+D++
Sbjct: 252 VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINA 311
Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY 420
F + ++L LK RLLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACIWY
Sbjct: 312 FENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWY 371
Query: 421 AIGNVERPYLEHKI----GWLDSLGVQLGKRY--NGSDPAS---GPSVQDKYVTALYFTF 471
+IG+ E + K WL L + +G Y NGS GPS Y+++LYFT
Sbjct: 372 SIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTM 431
Query: 472 SSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLR 531
+SLTSVGFGN++P+T+ EK+F++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH +
Sbjct: 432 TSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNS 491
Query: 532 VKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQH 591
V++F++ +Q+P L +R+ +Y WS + GID VL+ P+ ++ADIC+HL+R + +
Sbjct: 492 VRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKE 551
Query: 592 CPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAIL 651
PAF A GCLRALA++F+T H PGD + H G+ + +L F+ GS+E+++DD VVAIL
Sbjct: 552 HPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAIL 611
Query: 652 GKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVT 711
GK D+FG+ A +S A+VRALTYCDLH I+R L +VL+ Y AF+ SF L +T
Sbjct: 612 GKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILT 671
Query: 712 FNLR 715
+NLR
Sbjct: 672 YNLR 675
>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
isoform 1 [Homo sapiens]
Length = 989
Score = 543 bits (1398), Expect = e-154
Identities = 298/751 (39%), Positives = 438/751 (58%), Gaps = 94/751 (12%)
Query: 4 RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63
RRG VAPQNT+L+ I+R+ F++ NAQ+ + I+Y NDGFC+L GY R EVMQ+
Sbjct: 7 RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
Query: 64 CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123
TC F+ G T + ++ Q E +IL Y+K+ + V + P++NE V+
Sbjct: 65 STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
Query: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183
+F+ F D+ S G GK+
Sbjct: 125 LFLCTFSDITAFKQPIEDDSCK-------------------------GWGKFA------- 152
Query: 184 FTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTE--KVTQVLSLGADVLPEYKLQA 241
L + +SS ++ +AP V++ +NV + ++ +VL LG+D+LP+YK +A
Sbjct: 153 --------RLTRALTSSRGVLQQLAPS--VQKGENVHKHSRLAEVLQLGSDILPQYKQEA 202
Query: 242 PRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLT 301
P+ ILHY FK WDW+IL+L YTA+ PY+ +F ++R+ ++
Sbjct: 203 PKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSF------KTRQNNVAW-----L 251
Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIF 361
VVD IVD++F+VDIV+NF TT+V EV+S P+ I ++Y K WF+ID+++ +P+D++
Sbjct: 252 VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINA 311
Query: 362 RTGSDETTTLIG----------------------------LLKTARLLRLVRVARKLDRY 393
DE + +G LK RLLRL RVARKLD Y
Sbjct: 312 FENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLRLGRVARKLDHY 371
Query: 394 SEYGAAVLFLLMCTFALIAHWLACIWYAIGNVERPYLEHKI----GWLDSLGVQLGKRY- 448
EYGAAVL LL+C F L AHW+ACIWY+IG+ E + K WL L + +G Y
Sbjct: 372 IEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQ 431
Query: 449 -NGSDPA---SGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMY 504
NGS GPS Y+++LYFT +SLTSVGFGN++P+T+ EK+F++ +M+IGSL+Y
Sbjct: 432 FNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLY 491
Query: 505 ASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGID 564
A+IFGNV+ I Q++Y+ T RYH + V++F++ +Q+P L +R+ +Y WS + GID
Sbjct: 492 ATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGID 551
Query: 565 MNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHL 624
VL+ P+ ++ADIC+HL+R + + PAF A GCLRALA++F+T H PGD + H
Sbjct: 552 TEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHA 611
Query: 625 GDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHK 684
G+ + +L F+ GS+E+++DD VVAILGK D+FG+ A +S A+VRALTYCDLH
Sbjct: 612 GESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHV 671
Query: 685 IQRADLLEVLDMYPAFAESFWSKLEVTFNLR 715
I+R L +VL+ Y AF+ SF L +T+NLR
Sbjct: 672 IKRDALQKVLEFYTAFSHSFSRNLILTYNLR 702
>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
isoform 1 [Homo sapiens]
Length = 988
Score = 538 bits (1387), Expect = e-153
Identities = 286/722 (39%), Positives = 426/722 (59%), Gaps = 65/722 (9%)
Query: 4 RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63
+RG VAPQNT+L+ I+R+ S FL+ NAQ+ + ++Y NDGFC+L GY R +VMQ+
Sbjct: 5 KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62
Query: 64 CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123
TC F+ G T + ++ Q E ++L Y+K+ + + + P++NE V+
Sbjct: 63 STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
Query: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183
+F+ F+D+ S
Sbjct: 123 LFLCTFKDITLFKQPIEDDS---------------------------------------- 142
Query: 184 FTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAP 242
T + +F L + ++S + ++ + P E + ++ +VL LG+D+LP+YK +AP
Sbjct: 143 -TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYKQEAP 200
Query: 243 RIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTV 302
+ ILHY FK WDW+IL+L YTA+ PY+ +F + + V
Sbjct: 201 KTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA-----------WLV 249
Query: 303 VDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-IF 361
+D +VD++F+VDIV+NF TT+V EV+S P+ I ++Y K WF+ID+++ +P+D++ F
Sbjct: 250 LDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAF 309
Query: 362 RTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYA 421
+ ++L LK RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+
Sbjct: 310 ENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYS 369
Query: 422 IGNVER-PYLEHKI---GWLDSLGVQLGKRYNGSDPAS----GPSVQDKYVTALYFTFSS 473
IG+ E + + I WL L + +G Y + A GPS YV++LYFT +S
Sbjct: 370 IGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTS 429
Query: 474 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 533
LT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH + V+
Sbjct: 430 LTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVR 489
Query: 534 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 593
+F++ +Q+P L +R+ +Y WS + GID VL P+ ++ADIC+HL+R + P
Sbjct: 490 DFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHP 549
Query: 594 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAILGK 653
AF A GCLRALAV+F+T H PGD + H G+ + L F+ GS+E+++DD VVAILGK
Sbjct: 550 AFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAILGK 609
Query: 654 NDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVTFN 713
D+FG+ + A+VRALTYCDLH I+R LL+VLD Y AFA SF L +T N
Sbjct: 610 GDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLTLTCN 669
Query: 714 LR 715
LR
Sbjct: 670 LR 671
>gi|38569493 potassium voltage-gated channel, subfamily H
(eag-related), member 3 [Homo sapiens]
Length = 1083
Score = 536 bits (1382), Expect = e-152
Identities = 323/853 (37%), Positives = 464/853 (54%), Gaps = 93/853 (10%)
Query: 1 MPVRRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENC-AIIYCNDGFCELFGYSRVEV 59
MP RG +APQNT+LDTI +F+G F++ NAQ+ ++YC+DGFC+L G+SR EV
Sbjct: 1 MPAMRGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEV 60
Query: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
MQ+ C C FL GP+T ++ +AL +E K +++ YRK F CL+DV+P+KNE
Sbjct: 61 MQRGCACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEK 120
Query: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPG----PGTGRGKY 175
G V +F+++ +D+++ + GGP G GR +Y
Sbjct: 121 GEVALFLVSHKDISETKNR-------------------------GGPDRWKETGGGRRRY 155
Query: 176 -RTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVL 234
R S+ FN + RS + + ++ H +++ K+ + + L
Sbjct: 156 GRARSK---------GFNANRRRSRAV--LYHLSGH--LQKQPKGKHKLNKGVFGEKPNL 202
Query: 235 PEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACS 294
PEYK+ A R + +LH +A WD ILL +Y AV PYS + + + RG
Sbjct: 203 PEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVTVPYSVCVSTAREPSAARG--- 259
Query: 295 YTCSPLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAI 354
P +V DL V+++F++DIV+NFRTT+V+ + +VV P+ I +HY WFL+D++AA+
Sbjct: 260 ----PPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLHYVTTWFLLDVIAAL 315
Query: 355 PFDLLIFRTGSDETTTLIG--LLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIA 412
PFDLL + + G LLKT RLLRL+R+ +LDRYS+Y A VL LLM FAL+A
Sbjct: 316 PFDLL----HAFKVNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYSAVVLTLLMAVFALLA 371
Query: 413 HWLACIWYAIGNVERPYLEHK---IGWLDSLGVQLGKRY--------------------- 448
HW+AC+W+ IG E E + IGWL L +L Y
Sbjct: 372 HWVACVWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSS 431
Query: 449 ------NGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSL 502
G + GPS++ Y+T+LYF SSLTSVGFGNVS NT++EK+FSIC MLIG+L
Sbjct: 432 SSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGAL 491
Query: 503 MYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNG 562
M+A +FGNV+AIIQR+Y+ YH++ ++++IR H+IP PL+QR+ EYFQ W+ NG
Sbjct: 492 MHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNG 551
Query: 563 IDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLV 622
ID +L+ P+ L+ADI +HLH+ +LQ P F A +GCLRAL++ + PG+ L+
Sbjct: 552 IDTTELLQSLPDELRADIAMHLHKEVLQ-LPLFEAASRGCLRALSLALRPAFCTPGEYLI 610
Query: 623 HLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDL 682
H GD L LYF+ GS+E+L+ V+AILGK D+ G + Q K++ADV+ LTYC L
Sbjct: 611 HQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQVVKANADVKGLTYCVL 670
Query: 683 HKIQRADLLEVLDMYPAFAESFWSKL--EVTFNLRDAAGGLHSSPRQAPGSQDHQGFFLS 740
+Q A L + L +YP FA F L E+++NL G G
Sbjct: 671 QCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNLGAGGGSAEVDTSSLSGDNTLMSTLEE 730
Query: 741 DNQSGSPHELGPQFPSKGYS--LLGPGSQNSMGAGP-CAPGHPDAAPPLSISDASGLWPE 797
G P+ S LL PG +S A +P P L G
Sbjct: 731 KETDGEQGPTVSPAPADEPSSPLLSPGCTSSSSAAKLLSPRRTAPRPRLGGRGRPGRAGA 790
Query: 798 LLQEMPPRHSPQS 810
L E P P++
Sbjct: 791 LKAEAGPSAPPRA 803
>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
isoform 2 [Homo sapiens]
Length = 624
Score = 482 bits (1241), Expect = e-136
Identities = 258/666 (38%), Positives = 386/666 (57%), Gaps = 63/666 (9%)
Query: 60 MQQPCTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNED 119
MQ+ TC F+ G T + ++ Q E ++L Y+K+ + + + P++NE
Sbjct: 1 MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60
Query: 120 GAVIMFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTIS 179
V++F+ F+D+ S
Sbjct: 61 EKVVLFLCTFKDITLFKQPIEDDS------------------------------------ 84
Query: 180 QIPQFTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYK 238
T + +F L + ++S + ++ + P E + ++ +VL LG+D+LP+YK
Sbjct: 85 -----TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYK 138
Query: 239 LQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCS 298
+AP+ ILHY FK WDW+IL+L YTA+ PY+ +F + +
Sbjct: 139 QEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA---------- 188
Query: 299 PLTVVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDL 358
V+D +VD++F+VDIV+NF TT+V EV+S P+ I ++Y K WF+ID+++ +P+D+
Sbjct: 189 -WLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDI 247
Query: 359 L-IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLAC 417
+ F + ++L LK RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLAC
Sbjct: 248 INAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLAC 307
Query: 418 IWYAIGNVER-PYLEHKI---GWLDSLGVQLGKRYNGSDPAS----GPSVQDKYVTALYF 469
IWY+IG+ E + + I WL L + +G Y + A GPS YV++LYF
Sbjct: 308 IWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYF 367
Query: 470 TFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQM 529
T +SLT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH +
Sbjct: 368 TMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEML 427
Query: 530 LRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALL 589
V++F++ +Q+P L +R+ +Y WS + GID VL P+ ++ADIC+HL+R +
Sbjct: 428 NNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVF 487
Query: 590 QHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVA 649
PAF A GCLRALAV+F+T H PGD + H G+ + L F+ GS+E+++DD VVA
Sbjct: 488 NEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVA 547
Query: 650 ILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLE 709
ILGK D+FG+ + A+VRALTYCDLH I+R LL+VLD Y AFA SF L
Sbjct: 548 ILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFANSFSRNLT 607
Query: 710 VTFNLR 715
+T NLR
Sbjct: 608 LTCNLR 613
>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
isoform 3 [Homo sapiens]
Length = 611
Score = 478 bits (1231), Expect = e-135
Identities = 252/658 (38%), Positives = 385/658 (58%), Gaps = 65/658 (9%)
Query: 4 RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63
+RG VAPQNT+L+ I+R+ S FL+ NAQ+ + ++Y NDGFC+L GY R +VMQ+
Sbjct: 5 KRGLVAPQNTFLENIVRRSSESS--FLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQKS 62
Query: 64 CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123
TC F+ G T + ++ Q E ++L Y+K+ + + + P++NE V+
Sbjct: 63 STCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEKVV 122
Query: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183
+F+ F+D+ S
Sbjct: 123 LFLCTFKDITLFKQPIEDDS---------------------------------------- 142
Query: 184 FTLNFVEF-NLEKHRSSSTTEIEIIAPHKVVERTQNVTEKVTQVLSLGADVLPEYKLQAP 242
T + +F L + ++S + ++ + P E + ++ +VL LG+D+LP+YK +AP
Sbjct: 143 -TKGWTKFARLTRALTNSRSVLQQLTPMNKTEVVHKHS-RLAEVLQLGSDILPQYKQEAP 200
Query: 243 RIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTV 302
+ ILHY FK WDW+IL+L YTA+ PY+ +F + + V
Sbjct: 201 KTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA-----------WLV 249
Query: 303 VDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-IF 361
+D +VD++F+VDIV+NF TT+V EV+S P+ I ++Y K WF+ID+++ +P+D++ F
Sbjct: 250 LDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYDIINAF 309
Query: 362 RTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYA 421
+ ++L LK RLLRL RVARKLD Y EYGAAVL LL+C F L+AHWLACIWY+
Sbjct: 310 ENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLVAHWLACIWYS 369
Query: 422 IGNVER-PYLEHKI---GWLDSLGVQLGKRYNGSDPAS----GPSVQDKYVTALYFTFSS 473
IG+ E + + I WL L + +G Y + A GPS YV++LYFT +S
Sbjct: 370 IGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTSAGIWEGGPSKDSLYVSSLYFTMTS 429
Query: 474 LTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVK 533
LT++GFGN++P T+ EK+FS+ +M++GSL+YA+IFGNV+ I Q++Y+ T RYH + V+
Sbjct: 430 LTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANTNRYHEMLNNVR 489
Query: 534 EFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCP 593
+F++ +Q+P L +R+ +Y WS + GID VL P+ ++ADIC+HL+R + P
Sbjct: 490 DFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICVHLNRKVFNEHP 549
Query: 594 AFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAIL 651
AF A GCLRALAV+F+T H PGD + H G+ + L F+ GS+E+++DD VVAIL
Sbjct: 550 AFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVIQDDEVVAIL 607
>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
potassium channel 4 [Homo sapiens]
Length = 1203
Score = 186 bits (471), Expect = 1e-46
Identities = 132/480 (27%), Positives = 223/480 (46%), Gaps = 51/480 (10%)
Query: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306
W I YS F+ WD +LLL++ + P F +DE+ +P V +++
Sbjct: 253 WIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFF---KDENT--------TPWIVFNVV 301
Query: 307 VDIMFVVDIVINFRT-TYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363
D F++D+V+NFRT V N E++ P+RI + Y K WF++D +++IP D LI T
Sbjct: 302 SDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVET 361
Query: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR-----YSEYGAAVLFL-L 404
D T ++ LL+ RL RL+R + + Y A V + L
Sbjct: 362 RIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNL 421
Query: 405 MCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYV 464
+ L+ HW C+ + + P L+ + D V + N S +Y
Sbjct: 422 IGMMLLLCHWDGCLQFLV-----PMLQD---FPDDCWVSINNMVNNS-------WGKQYS 466
Query: 465 TALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 524
AL+ S + +G+G +P S+ ++ M++G+ YA G+ +A+IQ L S +
Sbjct: 467 YALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQ 526
Query: 525 YHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 584
Y + +V++++ FH++P RQR+ +Y++H + D ++L E L+ +I
Sbjct: 527 YQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRYQ-GKMFDEESILGELSEPLREEIINFN 585
Query: 585 HRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRD 644
R L+ P F+ A + ++ K + PGD ++ G + +YFI G + +L
Sbjct: 586 CRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTK 645
Query: 645 DVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESF 704
L FGE L G+ +A VRA TYC L+ + + EVL+ YP +F
Sbjct: 646 GNKETKLADGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 703
>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
potassium channel 2 [Homo sapiens]
Length = 889
Score = 180 bits (457), Expect = 5e-45
Identities = 128/482 (26%), Positives = 222/482 (46%), Gaps = 55/482 (11%)
Query: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306
W I YS F+ WD+ +LL ++ + P F +DE T +P V +++
Sbjct: 202 WIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFF---KDE--------TTAPWIVFNVV 250
Query: 307 VDIMFVVDIVINFRTTYV-NTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363
D F++D+V+NFRT V N E++ P +I Y + WF++D V++IP D LI
Sbjct: 251 SDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDYIFLIVEK 310
Query: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR--YSEYGAAVLFLLMCTF 408
G D T ++ LL+ RL RL+R + + + Y A + +C
Sbjct: 311 GIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVMRICNL 370
Query: 409 A----LIAHWLACIWYAIGNVERPYLEH--KIGWLDSLGVQLGKRYNGSDPASGPSVQDK 462
L+ HW C+ + + P L+ + W+ G+ S +
Sbjct: 371 ISMMLLLCHWDGCLQFLV-----PMLQDFPRNCWVSINGMV------------NHSWSEL 413
Query: 463 YVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 522
Y AL+ S + +G+G +P + ++ ++ M++G+ YA G+ +A+IQ L S
Sbjct: 414 YSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 473
Query: 523 ARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICL 582
+Y + +V++++ FH++P RQ++ +Y++H + D +++L L+ +I
Sbjct: 474 RQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRYQ-GKMFDEDSILGELNGPLREEIVN 532
Query: 583 HLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEIL 642
R L+ P F+ A + A+ K K PGD ++ G + +YFI G + +L
Sbjct: 533 FNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVL 592
Query: 643 RDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAE 702
L FGE L G+ +A VRA TYC L+ + + EVL+ YP
Sbjct: 593 TKGNKEMKLSDGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRR 650
Query: 703 SF 704
+F
Sbjct: 651 AF 652
>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
potassium channel 1 [Homo sapiens]
Length = 890
Score = 177 bits (449), Expect = 4e-44
Identities = 127/480 (26%), Positives = 223/480 (46%), Gaps = 51/480 (10%)
Query: 247 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLI 306
W I YS F+ WD ++L++++ V P F T +P + ++
Sbjct: 133 WIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQ-----------TTTPWIIFNVA 181
Query: 307 VDIMFVVDIVINFRTTYVNTND-EVVSHPRRIAVHYFKGWFLIDMVAAIPFD--LLIFRT 363
D +F++D+++NFRT VN + E++ P+ I ++Y K WF++D +++IP D LI
Sbjct: 182 SDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDYIFLIVEK 241
Query: 364 GSDET-------------TTLIGLLKTARLLRLVRVARKLDR-----YSEYGAAV-LFLL 404
G D T ++ LL+ RL RL+R + + Y A V +F L
Sbjct: 242 GMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNL 301
Query: 405 MCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYV 464
+ L+ HW C+ + + P L+ + V L + N S +Y
Sbjct: 302 IGMMLLLCHWDGCLQFLV-----PLLQD---FPPDCWVSLNEMVNDS-------WGKQYS 346
Query: 465 TALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTAR 524
AL+ S + +G+G +P + S+ ++ M++G+ YA G+ +A+IQ L S +
Sbjct: 347 YALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGHATALIQSLDSSRRQ 406
Query: 525 YHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHL 584
Y + +V++++ FH++P +RQ++ +Y++H + D +L + L+ +I
Sbjct: 407 YQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQ-GKIFDEENILNELNDPLREEIVNFN 465
Query: 585 HRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRD 644
R L+ P F+ A + A+ K + PGD ++ G V +YFI G ++
Sbjct: 466 CRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKMYFIQHGVAGVITK 525
Query: 645 DVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESF 704
L FGE L G+ +A VRA TYC L+ + + EVL+ YP +F
Sbjct: 526 SSKEMKLTDGSYFGEICLL--TKGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAF 583
>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
Length = 774
Score = 174 bits (441), Expect = 4e-43
Identities = 148/565 (26%), Positives = 245/565 (43%), Gaps = 88/565 (15%)
Query: 165 GPGPGTG-RGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKV 223
GP P +G K R + + Q T+N +F+L + HK VE Q
Sbjct: 35 GPIPKSGPEPKRRHLGTLLQPTVN--KFSLR-----------VFGSHKAVEIEQE----- 76
Query: 224 TQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLS 283
+V S GA W I YS F+ WD ++LLL++ + P F
Sbjct: 77 -RVKSAGA---------------WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE 120
Query: 284 DQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRT-TYVNTNDEVVSHPRRIAVHYF 342
+ P V +++ D F++D+V+NFRT V E++ PR I Y
Sbjct: 121 ENSP-----------PWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYL 169
Query: 343 KGWFLIDMVAAIPFDLL-------------IFRTGSD----ETTTLIGLLKTARLLRLVR 385
+ WFL+D++++IP D + +++T T ++ LL+ RL RL+R
Sbjct: 170 RTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIR 229
Query: 386 VARKLDR-----YSEYGAAV-LFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDS 439
+ + Y A V +F L+ L+ HW C+ + + P L+ +
Sbjct: 230 YIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLV-----PMLQD---FPPD 281
Query: 440 LGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLI 499
V + N S +Y AL+ S + +G+G +P + ++ M++
Sbjct: 282 CWVSINHMVNHSWGR-------QYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIV 334
Query: 500 GSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSY 559
G+ YA G+ +A+IQ L S +Y + +V++++ FH++P RQR+ EY++H +
Sbjct: 335 GATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ- 393
Query: 560 TNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGD 619
D ++L E L+ +I R L+ H P F+ A + A+ K + PGD
Sbjct: 394 GKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGD 453
Query: 620 TLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTY 679
+V G V +YFI G + +L L FGE L G+ +A VRA TY
Sbjct: 454 LVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLL--TRGRRTASVRADTY 511
Query: 680 CDLHKIQRADLLEVLDMYPAFAESF 704
C L+ + VL+ +P +F
Sbjct: 512 CRLYSLSVDHFNAVLEEFPMMRRAF 536
>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
[Homo sapiens]
Length = 676
Score = 162 bits (410), Expect = 1e-39
Identities = 114/408 (27%), Positives = 202/408 (49%), Gaps = 31/408 (7%)
Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360
V+D D+++V+D+++ RT ++ +VS R+ HY F +D+++ +P DL
Sbjct: 187 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 245
Query: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416
+ G++ LLK +RL Y G VL++L +I HW A
Sbjct: 246 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 300
Query: 417 CIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTS 476
CI++AI IG+ G N S P G + KY+ +LY++ +LT+
Sbjct: 301 CIYFAISKF--------IGF----GTDSWVYPNISIPEHG-RLSRKYIYSLYWSTLTLTT 347
Query: 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 536
+G P + E +F + L+G L++A+I GNV ++I + + A + ++ +K+++
Sbjct: 348 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 406
Query: 537 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 596
+F ++ L R+ +F + W+ +D VLK P+ L+A+I +++H L+ F
Sbjct: 407 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 466
Query: 597 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKN 654
G L L +K + T PGD + GD+ +Y I+ G + ++ DD V +L
Sbjct: 467 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 526
Query: 655 DIFGEPVSLHAQPGKS----SADVRALTYCDLHKIQRADLLEVLDMYP 698
FGE L+ + KS +A++R++ Y DL + + DL+E L YP
Sbjct: 527 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 574
>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
sapiens]
Length = 694
Score = 162 bits (410), Expect = 1e-39
Identities = 114/408 (27%), Positives = 202/408 (49%), Gaps = 31/408 (7%)
Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHY-FKGWFLIDMVAAIPFDLLI 360
V+D D+++V+D+++ RT ++ +VS R+ HY F +D+++ +P DL
Sbjct: 205 VLDYSADVLYVLDVLVRARTGFLEQG-LMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAY 263
Query: 361 FRTGSDETTTLIG-LLKTARLLRLVRVARKLDRYSEY---GAAVLFLLMCTFALIAHWLA 416
+ G++ LLK +RL Y G VL++L +I HW A
Sbjct: 264 LKVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYIL-----IIIHWNA 318
Query: 417 CIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTS 476
CI++AI IG+ G N S P G + KY+ +LY++ +LT+
Sbjct: 319 CIYFAISKF--------IGF----GTDSWVYPNISIPEHG-RLSRKYIYSLYWSTLTLTT 365
Query: 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 536
+G P + E +F + L+G L++A+I GNV ++I + + A + ++ +K+++
Sbjct: 366 IG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQYM 424
Query: 537 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 596
+F ++ L R+ +F + W+ +D VLK P+ L+A+I +++H L+ F
Sbjct: 425 QFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIFQ 484
Query: 597 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKN 654
G L L +K + T PGD + GD+ +Y I+ G + ++ DD V +L
Sbjct: 485 DCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSDG 544
Query: 655 DIFGEPVSLHAQPGKS----SADVRALTYCDLHKIQRADLLEVLDMYP 698
FGE L+ + KS +A++R++ Y DL + + DL+E L YP
Sbjct: 545 SYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYP 592
>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
[Homo sapiens]
Length = 759
Score = 157 bits (396), Expect = 6e-38
Identities = 117/447 (26%), Positives = 216/447 (48%), Gaps = 32/447 (7%)
Query: 259 WDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVIN 318
W + I L V+Y A F DE + Y ++D + DI++++D+ +
Sbjct: 237 WLFCITLPVMYNWTMVIARACF-----DELQSDYLEYWL----ILDYVSDIVYLIDMFVR 287
Query: 319 FRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTA 378
RT Y+ V + I + F +D+++ IP DLL F+ G + I L +
Sbjct: 288 TRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE--IRLNRLL 345
Query: 379 RLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWL 437
R R+ ++ + + Y + L+ +I HW AC++Y+I IG+
Sbjct: 346 RFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA--------IGFG 397
Query: 438 DSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVM 497
+ V + +DP G + KYV +LY++ +LT++G P +SE VF +
Sbjct: 398 NDTWVYP----DINDPEFGRLAR-KYVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVVVDF 451
Query: 498 LIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 557
LIG L++A+I GN+ ++I + + A + ++ +K+++ F + + +R+ ++F + W
Sbjct: 452 LIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLW 511
Query: 558 SYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPP 617
+ +D VLK P+ L+A+I +++H L+ F+ G L L +K + P
Sbjct: 512 TNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSP 571
Query: 618 GDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPGKS----S 671
GD + GD+ +Y I G + ++ DD V +L FGE L+ + K+ +
Sbjct: 572 GDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRT 631
Query: 672 ADVRALTYCDLHKIQRADLLEVLDMYP 698
A+++++ Y DL + + DL+E L YP
Sbjct: 632 ANIKSIGYSDLFCLSKDDLMEALTEYP 658
>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
sapiens]
Length = 690
Score = 157 bits (396), Expect = 6e-38
Identities = 117/447 (26%), Positives = 216/447 (48%), Gaps = 32/447 (7%)
Query: 259 WDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVIN 318
W + I L V+Y A F DE + Y ++D + DI++++D+ +
Sbjct: 168 WLFCITLPVMYNWTMVIARACF-----DELQSDYLEYWL----ILDYVSDIVYLIDMFVR 218
Query: 319 FRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLLIFRTGSDETTTLIGLLKTA 378
RT Y+ V + I + F +D+++ IP DLL F+ G + I L +
Sbjct: 219 TRTGYLEQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWNYPE--IRLNRLL 276
Query: 379 RLLRLVRVARKLDRYSEYGAAV-LFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWL 437
R R+ ++ + + Y + L+ +I HW AC++Y+I IG+
Sbjct: 277 RFSRMFEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKA--------IGFG 328
Query: 438 DSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVM 497
+ V + +DP G + KYV +LY++ +LT++G P +SE VF +
Sbjct: 329 NDTWVYP----DINDPEFGRLAR-KYVYSLYWSTLTLTTIG-ETPPPVRDSEYVFVVVDF 382
Query: 498 LIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 557
LIG L++A+I GN+ ++I + + A + ++ +K+++ F + + +R+ ++F + W
Sbjct: 383 LIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWFDYLW 442
Query: 558 SYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPP 617
+ +D VLK P+ L+A+I +++H L+ F+ G L L +K + P
Sbjct: 443 TNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQVYSP 502
Query: 618 GDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGKNDIFGEPVSLHAQPGKS----S 671
GD + GD+ +Y I G + ++ DD V +L FGE L+ + K+ +
Sbjct: 503 GDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAGNRRT 562
Query: 672 ADVRALTYCDLHKIQRADLLEVLDMYP 698
A+++++ Y DL + + DL+E L YP
Sbjct: 563 ANIKSIGYSDLFCLSKDDLMEALTEYP 589
>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
Length = 664
Score = 149 bits (377), Expect = 1e-35
Identities = 111/413 (26%), Positives = 197/413 (47%), Gaps = 41/413 (9%)
Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLI 360
V+D + D++++ D+ I RT ++ +V +++ +Y F +D+ + IP DL+
Sbjct: 177 VLDYVSDVVYIADLFIRLRTGFLEQG-LLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIY 235
Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYS---------EYGAAVLFLLMCTFALI 411
F ++ RLL R+ DR VL++L+ I
Sbjct: 236 FAVDIHSPE-----VRFNRLLHFARMFEFFDRTETRTNYPNIFRISNLVLYILV-----I 285
Query: 412 AHWLACIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTF 471
HW ACI+YAI IG+ GV N +DP G ++ Y+ LY++
Sbjct: 286 IHWNACIYYAISK--------SIGF----GVDTWVYPNITDPEYGYLARE-YIYCLYWST 332
Query: 472 SSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLR 531
+LT++G P + E +F I LIG L++A+I GNV ++I + + A + ++
Sbjct: 333 LTLTTIG-ETPPPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDA 391
Query: 532 VKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQH 591
VK +++F ++ + ++ +F + W+ +D +LK P L+A+I +++H + L+
Sbjct: 392 VKHYMQFRKVSKGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKK 451
Query: 592 CPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--A 649
F G L L +K + PGD + GD+ +Y I G + ++ DD V A
Sbjct: 452 VRIFHDCEAGLLVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYA 511
Query: 650 ILGKNDIFGEPVSLHAQPGK----SSADVRALTYCDLHKIQRADLLEVLDMYP 698
+L FGE L+ + K +A++R+L Y DL + + DL+E + YP
Sbjct: 512 LLSAGSCFGEISILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYP 564
>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
Length = 575
Score = 137 bits (345), Expect = 5e-32
Identities = 102/409 (24%), Positives = 193/409 (47%), Gaps = 33/409 (8%)
Query: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLI 360
V+D D+++++D+V+ F T ++ VV R I+ Y + W F +D+ + +P D++
Sbjct: 71 VLDYTSDLLYLLDMVVRFHTGFLEQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVVY 129
Query: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEY----GAAVLFLLMCTFALIAHWLA 416
R G T L+ R LR R+ DR A + LM ++ HW +
Sbjct: 130 VRLGPHTPT-----LRLNRFLRAPRLFEAFDRTETRTAYPNAFRIAKLMLYIFVVIHWNS 184
Query: 417 CIWYAIGNVERPYLEH-KIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLT 475
C+++A+ YL + W+ Q G ++ +Y+ + YF+ LT
Sbjct: 185 CLYFALSR----YLGFGRDAWVYPDPAQPGFE----------RLRRQYLYSFYFSTLILT 230
Query: 476 SVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEF 535
+VG P E +F + L+ + +A+I G++S++I + + A ++ VK++
Sbjct: 231 TVG-DTPPPAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKY 289
Query: 536 IRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAF 595
++ + L +R+ +++QH + A+L+ PE L+A++ + +H + L F
Sbjct: 290 MKLQHVNRKLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIF 349
Query: 596 SGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVV--AILGK 653
L L +K + PG+ + GD+ +Y I G + ++ DD + A+LG
Sbjct: 350 QNCEASLLEELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGA 409
Query: 654 NDIFGEPVSLHAQPGKS----SADVRALTYCDLHKIQRADLLEVLDMYP 698
FGE ++ + S +A++++L Y DL + + DL EVL YP
Sbjct: 410 GLYFGEISIINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYP 458
>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
sapiens]
Length = 1251
Score = 93.6 bits (231), Expect = 8e-19
Identities = 83/407 (20%), Positives = 185/407 (45%), Gaps = 39/407 (9%)
Query: 302 VVDLIVDIMFVVDI-VINFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLL 359
++D + D+++ +DI V R +V D +++ + + +Y K F +D+++ +P D L
Sbjct: 693 LMDYLCDLIYFLDITVFQTRLQFVRGGD-IITDKKDMRNNYLKSRRFKMDLLSLLPLDFL 751
Query: 360 IFRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWL---A 416
+ G L+ L + + + +L+ S A ++ ++ T A + + L +
Sbjct: 752 YLKVG---VNPLLRLPRCLKYMAFFEFNSRLE--SILSKAYVYRVIRTTAYLLYSLHLNS 806
Query: 417 CIWYAIGNVERPYLEHKIGWLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTS 476
C++Y + H W+ Y+G V + Y+ YF +L +
Sbjct: 807 CLYYWASAYQGLGSTH---WV----------YDG--------VGNSYIRCYYFAVKTLIT 845
Query: 477 VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFI 536
+G G P T E VF + G ++ + G + ++ +G Y + M +++
Sbjct: 846 IG-GLPDPKTLFEIVFQLLNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYM 904
Query: 537 RFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFS 596
F++IP ++ R++ ++++ W +D + ++ P+ ++ D+ + ++ ++ F
Sbjct: 905 NFYKIPKSVQNRVKTWYEYTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQ 964
Query: 597 GAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEIL---RDDVVVAILGK 653
G + + + + ++ P D + G++ +Y I G +++L V+ L
Sbjct: 965 GCDRQMIFDMLKRLRSVVYLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKA 1024
Query: 654 NDIFGEPVSLHAQPG--KSSADVRALTYCDLHKIQRADLLEVLDMYP 698
+FGE +SL A G + +A+V A + +L + + DL E+L YP
Sbjct: 1025 GSVFGE-ISLLAVGGGNRRTANVVAHGFTNLFILDKKDLNEILVHYP 1070
>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
Length = 809
Score = 88.6 bits (218), Expect = 3e-17
Identities = 96/453 (21%), Positives = 185/453 (40%), Gaps = 56/453 (12%)
Query: 261 WLILLLVIYT--AVFTPYSAAFLLSDQDESRRGACSYTCSPLTVVDLIVDIMFVVDIV-I 317
WL+L+ + Y F P F D + D+I DI+++ D++ I
Sbjct: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWL---------IADIICDIIYLYDMLFI 271
Query: 318 NFRTTYVNTNDEVVSHPRRIAVHYFKGW-FLIDMVAAIPFDLLIFRTGSDETTTLIGLLK 376
R +V D +V + HY F +D+ + IPFD+ G + +LK
Sbjct: 272 QPRLQFVRGGDIIVDS-NELRKHYRTSTKFQLDVASIIPFDICYLFFGFNPMFRANRMLK 330
Query: 377 TARLLRLVRVARKLDRYSEYGAAVLFLLMCT---FALIAHWLACIWYAIGNVERPYLEHK 433
+ A ++ ++ T I H AC++Y N E
Sbjct: 331 YTSFFEFNHHLESI-----MDKAYIYRVIRTTGYLLFILHINACVYYWASNYEG------ 379
Query: 434 IG---WLDSLGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 490
IG W+ Y+G ++Y+ Y+ +L ++G G P T E
Sbjct: 380 IGTTRWV----------YDGEG--------NEYLRCYYWAVRTLITIG-GLPEPQTLFEI 420
Query: 491 VFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLE 550
VF + G +++S+ G + +I + + M ++ + IP +++R+
Sbjct: 421 VFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVR 480
Query: 551 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKF 610
++++ W +D + +LK P +Q + + ++ +++ F G + + ++
Sbjct: 481 TWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRL 540
Query: 611 KTTHAPPGDTLVHLGDVLSTLYFISRGSIEIL---RDDVVVAILGKNDIFGEPVSLHAQP 667
K+ PGD + G++ +Y I G +++L V+ L +FGE +SL A
Sbjct: 541 KSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGE-ISLLAAG 599
Query: 668 G--KSSADVRALTYCDLHKIQRADLLEVLDMYP 698
G + +A+V A + +L + + L E+L YP
Sbjct: 600 GGNRRTANVVAHGFANLLTLDKKTLQEILVHYP 632
>gi|205361107 potassium channel, subfamily K, member 17 isoform 2
[Homo sapiens]
Length = 271
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/84 (28%), Positives = 49/84 (58%), Gaps = 3/84 (3%)
Query: 437 LDSLGVQLGKRY-NGSDPASGPSVQDKY--VTALYFTFSSLTSVGFGNVSPNTNSEKVFS 493
LDSL + + Y NG+ S + ++ V + +F+ S++T++G+GN+SPNT + ++F
Sbjct: 74 LDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFC 133
Query: 494 ICVMLIGSLMYASIFGNVSAIIQR 517
I L+G + + + ++Q+
Sbjct: 134 IFFALVGIPLNLVVLNRLGHLMQQ 157
>gi|17025230 potassium channel, subfamily K, member 17 isoform 1
[Homo sapiens]
Length = 332
Score = 42.7 bits (99), Expect = 0.002
Identities = 24/84 (28%), Positives = 49/84 (58%), Gaps = 3/84 (3%)
Query: 437 LDSLGVQLGKRY-NGSDPASGPSVQDKY--VTALYFTFSSLTSVGFGNVSPNTNSEKVFS 493
LDSL + + Y NG+ S + ++ V + +F+ S++T++G+GN+SPNT + ++F
Sbjct: 74 LDSLIRDVVQAYKNGASLLSNTTSMGRWELVGSFFFSVSTITTIGYGNLSPNTMAARLFC 133
Query: 494 ICVMLIGSLMYASIFGNVSAIIQR 517
I L+G + + + ++Q+
Sbjct: 134 IFFALVGIPLNLVVLNRLGHLMQQ 157
>gi|148612818 protein kinase, cGMP-dependent, type I isoform 1 [Homo
sapiens]
Length = 671
Score = 40.4 bits (93), Expect = 0.008
Identities = 24/77 (31%), Positives = 37/77 (48%), Gaps = 6/77 (7%)
Query: 589 LQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDD--- 645
L+ P F + L LA + TH G+ ++ G T + IS+G++ + R+D
Sbjct: 216 LKSVPTFQSLPEEILSKLADVLEETHYENGEYIIRQGARGDTFFIISKGTVNVTREDSPS 275
Query: 646 ---VVVAILGKNDIFGE 659
V + LGK D FGE
Sbjct: 276 EDPVFLRTLGKGDWFGE 292
Score = 31.6 bits (70), Expect = 3.9
Identities = 13/44 (29%), Positives = 25/44 (56%)
Query: 621 LVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLH 664
++ GDV S +Y + G +E+ ++ V + +G +FGE L+
Sbjct: 130 IIKEGDVGSLVYVMEDGKVEVTKEGVKLCTMGPGKVFGELAILY 173
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.423
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,827,227
Number of Sequences: 37866
Number of extensions: 2116250
Number of successful extensions: 10510
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 68
Number of HSP's successfully gapped in prelim test: 202
Number of HSP's that attempted gapping in prelim test: 9758
Number of HSP's gapped (non-prelim): 947
length of query: 994
length of database: 18,247,518
effective HSP length: 112
effective length of query: 882
effective length of database: 14,006,526
effective search space: 12353755932
effective search space used: 12353755932
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.