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Search of human proteins with 5803221
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
(943 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 1880 0.0
gi|32189425 WD repeat domain 69 [Homo sapiens] 111 4e-24
gi|19913369 transducin beta-like 3 [Homo sapiens] 107 7e-23
gi|13376840 WD repeat domain 61 [Homo sapiens] 104 4e-22
gi|32483361 apoptotic peptidase activating factor 1 isoform d [H... 103 8e-22
gi|4502123 apoptotic peptidase activating factor 1 isoform b [Ho... 103 8e-22
gi|48928050 F-box and WD repeat domain containing 11 isoform C [... 99 2e-20
gi|48928048 F-box and WD repeat domain containing 11 isoform A [... 99 2e-20
gi|48928046 F-box and WD repeat domain containing 11 isoform B [... 99 2e-20
gi|23199987 WD repeat domain 5B [Homo sapiens] 97 9e-20
gi|4502477 beta-transducin repeat containing protein isoform 2 [... 96 2e-19
gi|16117783 beta-transducin repeat containing protein isoform 1 ... 96 2e-19
gi|32483359 apoptotic peptidase activating factor 1 isoform c [H... 96 2e-19
gi|7108333 apoptotic peptidase activating factor 1 isoform a [Ho... 96 2e-19
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 94 8e-19
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 93 1e-18
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 93 1e-18
gi|113865883 WD repeat domain 38 [Homo sapiens] 93 1e-18
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 92 2e-18
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 92 2e-18
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 92 2e-18
gi|16554629 WD repeat domain 5 [Homo sapiens] 91 7e-18
gi|16554627 WD repeat domain 5 [Homo sapiens] 91 7e-18
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 89 1e-17
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 88 4e-17
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 87 6e-17
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 87 1e-16
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 86 2e-16
gi|4757988 WD repeat domain 39 [Homo sapiens] 86 2e-16
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 84 5e-16
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 1880 bits (4870), Expect = 0.0
Identities = 943/943 (100%), Positives = 943/943 (100%)
Query: 1 MGLTKQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILI 60
MGLTKQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILI
Sbjct: 1 MGLTKQYLRYVASAVFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILI 60
Query: 61 LQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGG 120
LQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGG
Sbjct: 61 LQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGG 120
Query: 121 RLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT 180
RLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT
Sbjct: 121 RLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT 180
Query: 181 QHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDPKKIKGS 240
QHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDPKKIKGS
Sbjct: 181 QHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDPKKIKGS 240
Query: 241 SPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHGTD 300
SPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHGTD
Sbjct: 241 SPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHGTD 300
Query: 301 SVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIK 360
SVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIK
Sbjct: 301 SVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTNIK 360
Query: 361 TSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRT 420
TSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRT
Sbjct: 361 TSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRT 420
Query: 421 LSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQL 480
LSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQL
Sbjct: 421 LSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQL 480
Query: 481 YDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSV 540
YDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSV
Sbjct: 481 YDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSV 540
Query: 541 KQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIS 600
KQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIS
Sbjct: 541 KQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIS 600
Query: 601 HDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW 660
HDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW
Sbjct: 601 HDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW 660
Query: 661 DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMERE 720
DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMERE
Sbjct: 661 DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMERE 720
Query: 721 AEYEESVAKEDQPAVPGETQGDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAI 780
AEYEESVAKEDQPAVPGETQGDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAI
Sbjct: 721 AEYEESVAKEDQPAVPGETQGDSYFTGKKTIETVKAAERIMEAIELYREETAKMKEHKAI 780
Query: 781 CKAAGKEVPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFN 840
CKAAGKEVPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFN
Sbjct: 781 CKAAGKEVPLPSNPILMAYGSISPSAYVLEIFKGIKSSELEESLLVLPFSYVPDILKLFN 840
Query: 841 EFIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMA 900
EFIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMA
Sbjct: 841 EFIQLGSDVELICRCLFFLLRIHFGQITSNQMLVPVIEKLRETTISKVSQVRDVIGFNMA 900
Query: 901 GLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT 943
GLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT
Sbjct: 901 GLDYLKRECEAKSEVMFFADATSHLEEKKRKRKKREKLILTLT 943
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 111 bits (277), Expect = 4e-24
Identities = 76/298 (25%), Positives = 136/298 (45%), Gaps = 17/298 (5%)
Query: 410 TIGGHRSDVRTLSFSS---DNIAVLSAAADSIKIWNRSTLQCIRTMTCEYA--LCSFFVP 464
T+ GHR+ V ++F++ D IA + + K+W+ T +C T A +C F P
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIAT-GSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNP 187
Query: 465 GDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
V G+ +L+D+ +G + T+ H + S+S + +TG D +V WD
Sbjct: 188 QSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Query: 525 FELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFF 584
+ T +++++ ++ S++ + L+ +D T K++ K
Sbjct: 248 AD-------TGRKVNILIGHCAEISS----ASFNWDCSLILTGSMDKTCKLWDATNGKCV 296
Query: 585 LSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPK 644
+L GH ++ + G LIAT SAD +I+ C L H+ + + F P+
Sbjct: 297 ATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNPQ 356
Query: 645 SHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
+ T D + WDA + +Q LEGH EI+ A + G+ V++ S D + R+W
Sbjct: 357 GNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 96.7 bits (239), Expect = 9e-20
Identities = 66/270 (24%), Positives = 124/270 (45%), Gaps = 18/270 (6%)
Query: 439 KIWNRSTLQCIRTM----TCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDA 494
K+W+ ++ + + T+ YA+ +F P ++ G+ +L+ + +G T
Sbjct: 117 KLWDTASGEELNTLEGHRNVVYAI-AFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRG 175
Query: 495 HDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQ-LDEDVL 553
H + +S +P TG D + K WD + + ++ TL+ +++
Sbjct: 176 HTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQ------------NGEEVYTLRGHSAEII 223
Query: 554 CVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADR 613
+S++ + + D TV ++ DT + L GH + + D +LI TGS D+
Sbjct: 224 SLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDK 283
Query: 614 NVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEG 673
K+W G C +L HDD ++ F L TA D + + A + I LEG
Sbjct: 284 TCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEG 343
Query: 674 HHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
H EI ++ +P G+++++ S DK+ R+W+
Sbjct: 344 HEGEISKISFNPQGNHLLTGSSDKTARIWD 373
Score = 95.9 bits (237), Expect = 2e-19
Identities = 57/219 (26%), Positives = 102/219 (46%), Gaps = 12/219 (5%)
Query: 488 LLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQ 547
L + + AH L +++L+ F+TG D++ K WD ++ N+ + +V
Sbjct: 84 LFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNV------- 136
Query: 548 LDEDVLCVSYS-PNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALI 606
V ++++ P +A D T K++ V+T K + + GH ++C+ + L+
Sbjct: 137 ----VYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLV 192
Query: 607 ATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFE 666
ATGS D K+W + G+ +L H ++ L F T DH + WDAD
Sbjct: 193 ATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGR 252
Query: 667 HIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705
+ L GH EI + + +++ S DK+ +LW+ T
Sbjct: 253 KVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDAT 291
Score = 95.9 bits (237), Expect = 2e-19
Identities = 62/246 (25%), Positives = 107/246 (43%), Gaps = 12/246 (4%)
Query: 470 VIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLS-PDQRGFVTGGADKSVKFWDFELV 528
+ G+ +L+D ASG L T++ H +++++ + P TG DK+ K W E
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
Query: 529 KDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLY 588
K ++ + + +++C+S++P L+A +D T K++ + + +L
Sbjct: 168 KCYHTFRGHTA-----------EIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Query: 589 GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLF 648
GH +I + + G I TGS D V +W D G L H + F L
Sbjct: 217 GHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLI 276
Query: 649 FTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREP 708
T D K WDA + + TL GH EI +G + ++S D + R++
Sbjct: 277 LTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRK 336
Query: 709 LILEEE 714
I + E
Sbjct: 337 CIAKLE 342
Score = 89.7 bits (221), Expect = 1e-17
Identities = 50/172 (29%), Positives = 85/172 (49%), Gaps = 1/172 (0%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLC-PSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHK 107
+WD GE++ L+G + V + +P G +A G D + +++S+ +G+ TF GH
Sbjct: 118 LWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHT 177
Query: 108 AAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTS 167
A I L ++ +A+GS DT +WD+ N +Y L+GH I F + ++T
Sbjct: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITG 237
Query: 168 GKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
D V WD DT ++GH E+ + ++TG+ D ++WD
Sbjct: 238 SFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWD 289
Score = 87.8 bits (216), Expect = 4e-17
Identities = 63/233 (27%), Positives = 101/233 (43%), Gaps = 13/233 (5%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+W + G+ +G E+ CL +P +A G D + +++ + +GE T GH A
Sbjct: 161 LWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSA 220
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSG 168
I +L ++ G R+ +GS D ++VWD + L GH I+ A F + +L++T
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTGS 280
Query: 169 KDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIED 228
D K WD C T+ GH E+ K + T ++D R++ A + I
Sbjct: 281 MDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAK 340
Query: 229 PE--EPDPKKIK----------GSSPGIQDTLEAEDG-AFETDEAPEDRILSC 268
E E + KI GSS +A+ G + E D I SC
Sbjct: 341 LEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSC 393
Score = 79.7 bits (195), Expect = 1e-14
Identities = 52/209 (24%), Positives = 93/209 (44%), Gaps = 13/209 (6%)
Query: 22 QKGNIVFVTLRGEKGRYVAVP-----------ACEH-VFIWDLRKGEKILILQGLKQEVT 69
Q G V+ TLRG +++ + +H V +WD G K+ IL G E++
Sbjct: 207 QNGEEVY-TLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEIS 265
Query: 70 CLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDT 129
+ D + G D + +++ +G+ T GH I +D G +A+ S D
Sbjct: 266 SASFNWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADG 325
Query: 130 DIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVG 189
++ + +L+GH+ I++ F + N L+T D + WD T C + + G
Sbjct: 326 TARIFSAATRKCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEG 385
Query: 190 HRTEVWGLVLLSEEKRLITGASDSELRVW 218
H E++ + +ITG+ D+ R+W
Sbjct: 386 HTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 68.6 bits (166), Expect = 3e-11
Identities = 41/153 (26%), Positives = 68/153 (44%), Gaps = 1/153 (0%)
Query: 68 VTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQ-LGGRLASGS 126
+T + + G G D + +++ SGE T GH+ + + ++ G ++A+GS
Sbjct: 95 LTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGS 154
Query: 127 KDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKT 186
D +W V + +GH I F + L+ T DT K WD+ T
Sbjct: 155 FDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYT 214
Query: 187 MVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
+ GH E+ L + R+ITG+ D + VWD
Sbjct: 215 LRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Score = 63.5 bits (153), Expect = 9e-10
Identities = 41/167 (24%), Positives = 64/167 (38%), Gaps = 43/167 (25%)
Query: 580 TLKFFLSLYGHKLPVICMDISHDGALIATGSADR-------------------------- 613
T F L H LP+ + ++ G+ TGS DR
Sbjct: 81 TFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAI 140
Query: 614 -----------------NVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHK 656
K+W ++ G C+ + H ++ L F P+S L T D
Sbjct: 141 AFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTT 200
Query: 657 IKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
K WD E + TL GH EI L+ + SGD +++ S D ++ +W+
Sbjct: 201 AKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD 247
Score = 57.8 bits (138), Expect = 5e-08
Identities = 36/144 (25%), Positives = 62/144 (43%), Gaps = 7/144 (4%)
Query: 90 RIFSLLSGEGNVTF------NGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLY 143
R+ L N TF H +T + ++ G +GS D +WD + L
Sbjct: 69 RLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELN 128
Query: 144 RLKGHKDAITQALFLREKNLLVTSGK-DTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSE 202
L+GH++ + F + +G D K W ++T C+ T GH E+ L +
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQ 188
Query: 203 EKRLITGASDSELRVWDIAYLQEI 226
+ TG+ D+ ++WDI +E+
Sbjct: 189 STLVATGSMDTTAKLWDIQNGEEV 212
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 107 bits (266), Expect = 7e-23
Identities = 64/225 (28%), Positives = 108/225 (48%), Gaps = 10/225 (4%)
Query: 512 VTGGADKSVKFWDFE--LVKDENSTQKRLSVKQTRTLQL--DEDVLCVSYSPNQKLLAVS 567
VTG D +VK W L+ + + Q +T Q D+D+ V+ +PN KLLA
Sbjct: 438 VTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATG 497
Query: 568 LLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHK 627
D T K++ + + GH+ + C+ S ++AT SAD +K+W L C K
Sbjct: 498 SQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLK 557
Query: 628 SLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSG 687
+ HD SV+ + FV + ++G D +K W E ++TL+ H ++W L S
Sbjct: 558 TFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLD 617
Query: 688 DYVVSSSHDKSLRLWERTREPLILEEEREMEREAEYEESVAKEDQ 732
D+ ++ + D + LW+ + E + E +A EE V ++ +
Sbjct: 618 DHALTGASDSRVILWKD------VTEAEQAEEQARQEEQVVRQQE 656
Score = 84.0 bits (206), Expect = 6e-16
Identities = 43/174 (24%), Positives = 91/174 (52%), Gaps = 1/174 (0%)
Query: 66 QEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASG 125
+++ + +P+ LA G +D + ++++L + F+GH+ + +++ + LA+
Sbjct: 480 KDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATA 539
Query: 126 SKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFK 185
S D I +W + + S L +GH ++ + F+ L++SG D +VK W + C +
Sbjct: 540 SADGTIKLWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVR 599
Query: 186 TMVGHRTEVWGLVLLSEEKRLITGASDSELRVW-DIAYLQEIEDPEEPDPKKIK 238
T+ H +VWGL + +TGASDS + +W D+ ++ E+ + + ++
Sbjct: 600 TLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAEQAEEQARQEEQVVR 653
Score = 75.9 bits (185), Expect = 2e-13
Identities = 131/617 (21%), Positives = 216/617 (35%), Gaps = 99/617 (16%)
Query: 60 ILQGLKQE----VTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG---HKAAITT 112
+L+ L+QE +T SPD L ++ + EG+VT H A + T
Sbjct: 57 VLRSLEQEDQEDITAFDLSPDNEVLVTASR--ALLLAQWAWQEGSVTRLWKAIHTAPVAT 114
Query: 113 LKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLRE--KNLLVTSGKD 170
+ +D LA+G D + VWD++ G + +G + F + + LL +S D
Sbjct: 115 MAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLLLFSSATD 174
Query: 171 TMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIED-- 228
++ W L + C + H + V L ++ +++ D +WD+ Q
Sbjct: 175 AAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVP 234
Query: 229 -----------PEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMRE 277
PEEP ++ SPG+ + G EA + C +
Sbjct: 235 VFESVEAAVLLPEEP-VSQLGVKSPGLYFLTAGDQGTLRVWEAASGQ---CVYTQAQPPG 290
Query: 278 GRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGE 337
+ + + T ++ D L L+ +AR G
Sbjct: 291 PGQELTHCTLAHTAGVVLTATADHNLLLY-----------------EARSLRLQKQFAGY 333
Query: 338 EEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSP----HGELKAVFLLQNNLVELYS 393
E EV L E V S +K F+L S HG V L ++
Sbjct: 334 SE--EVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLAL--DVFRKGW 389
Query: 394 LNPSLPTPQPVRTSRITI----------GGHRSDVRTLSFS--SDNIAVLSAAADSIKIW 441
L S Q VR R+ GH V T+ S ++ V + ++K+W
Sbjct: 390 LFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLW 449
Query: 442 -------NRST--------LQCIRTMTCEYALCS--FFVPGDRQVVIGTKTGKLQLYDLA 484
+++T LQ T C + P D+ + G++ +L+ L
Sbjct: 450 PLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALP 509
Query: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFW---DFELVKDENSTQKRLSVK 541
LL H LW + SP + T AD ++K W DF +K
Sbjct: 510 QCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGH------- 562
Query: 542 QTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISH 601
D VL V++ L S D VK++ + + +L H+ V + S
Sbjct: 563 -------DASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSR 615
Query: 602 DGALIATGSADRNVKIW 618
TG++D V +W
Sbjct: 616 LDDHALTGASDSRVILW 632
Score = 66.2 bits (160), Expect = 1e-10
Identities = 106/519 (20%), Positives = 195/519 (37%), Gaps = 63/519 (12%)
Query: 73 PSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDII 132
P P L L D +IR++SL H +A+T+L + G + S +D I
Sbjct: 161 PDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICI 220
Query: 133 VWDVINESGLYRLKGHKDAITQALFLREKNL-----------LVTSGKDTMVKWWDLDTQ 181
+WD + R +++ A+ L E+ + +T+G ++ W+ +
Sbjct: 221 IWD-LQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASG 279
Query: 182 HCFKTMV---GHRTEVWGLVLLSEEKRLITGASDSELRVWDI----------AYLQEIED 228
C T G E+ L ++T +D L +++ Y +E+ D
Sbjct: 280 QCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSEEVLD 339
Query: 229 PEEPDPKK----IKGSSPGIQDTLEAEDGAFETDEAPEDRILSC---RKAGSIMREGRDR 281
P+ + +SP ++ E + A + D +L+ RK +D+
Sbjct: 340 VRFLGPEDSHVVVASNSPCLK-VFELQTSACQILHGHTDIVLALDVFRKGWLFASCAKDQ 398
Query: 282 VVNL-AVDKTGRILACHG----TDSVLELFCILSKKE--IQKKMDKKMKK-ARKKAKLHS 333
V + ++K G+++ T SV + C K+ + D +K KA L
Sbjct: 399 SVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSK 458
Query: 334 SKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYS 393
+ + P + + Q + N A S K L Q L+ ++S
Sbjct: 459 NTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWALPQCQLLGVFS 518
Query: 394 LNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTM 452
GHR + + FS + + +A+AD +IK+W C++T
Sbjct: 519 -------------------GHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTF 559
Query: 453 TCEYA--LCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRG 510
A L FV Q++ G ++L+ + + + T+DAH+ +W + S
Sbjct: 560 EGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDH 619
Query: 511 FVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLD 549
+TG +D V W ++ Q R + R +LD
Sbjct: 620 ALTGASDSRVILWKDVTEAEQAEEQARQEEQVVRQQELD 658
Score = 58.9 bits (141), Expect = 2e-08
Identities = 74/334 (22%), Positives = 138/334 (41%), Gaps = 48/334 (14%)
Query: 405 RTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKI-WNRSTLQCIRTMTC-EYALCSFF 462
R+ + H S V +L+FS+D +LS+ D I I W+ + Q RT+ E +
Sbjct: 185 RSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVL 244
Query: 463 VPGDRQVVIGTKT-----------GKLQLYDLASGNLLETIDAHDGA---LWSMSLSPDQ 508
+P + +G K+ G L++++ ASG + T G L +L+
Sbjct: 245 LPEEPVSQLGVKSPGLYFLTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTA 304
Query: 509 RGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSY-SPNQKLLAVS 567
+T AD ++ ++ ++ Q + E+VL V + P + V+
Sbjct: 305 GVVLTATADHNLLLYEARSLR-----------LQKQFAGYSEEVLDVRFLGPEDSHVVVA 353
Query: 568 LLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGD--- 624
+K+F + T + L+GH V+ +D+ G L A+ + D++V+IW ++
Sbjct: 354 SNSPCLKVFELQTSACQI-LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVM 412
Query: 625 CHKSLFAHDDSVMYLQFVP-KSHLFFTAGKDHKIKQWDADK---------------FEHI 668
C H SV + K T +D +K W K +
Sbjct: 413 CVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQ 472
Query: 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
T H ++I +A++P+ + + S D++ +LW
Sbjct: 473 TTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLW 506
Score = 51.2 bits (121), Expect = 4e-06
Identities = 49/242 (20%), Positives = 97/242 (40%), Gaps = 27/242 (11%)
Query: 477 KLQLYDLASGNLLETIDAHDGA-LWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQ 535
++ + ++ASG +L +++ D + + LSPD VT + W ++ E S
Sbjct: 46 RVNILEVASGAVLRSLEQEDQEDITAFDLSPDNEVLVTASRALLLAQWAWQ----EGSVT 101
Query: 536 KRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLP-- 593
+ T V +++ P LLA D V+++ D ++ + + + P
Sbjct: 102 RLWKAIHTAP------VATMAFDPTSTLLATGGCDGAVRVW--DIVRHYGTHHFRGSPGV 153
Query: 594 --VICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTA 651
++ L+ + + D +++W L C L AH +V L F H ++
Sbjct: 154 VHLVAFHPDPTRLLLFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSS 213
Query: 652 GKDHKIKQWDADKFEHIQTLEGH----------HQEIWCLAVSPSGDYVVSSSHDKSLRL 701
G+D WD + +T+ + + L V G Y +++ +LR+
Sbjct: 214 GRDKICIIWDLQSCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRV 273
Query: 702 WE 703
WE
Sbjct: 274 WE 275
Score = 50.4 bits (119), Expect = 8e-06
Identities = 31/128 (24%), Positives = 59/128 (46%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+W L + + + + G ++ + C+ SP LA DG+I++++L TF GH A
Sbjct: 505 LWALPQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQDFSCLKTFEGHDA 564
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSG 168
++ + + G +L S D + +W + N + L H+D + R + +T
Sbjct: 565 SVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHEDKVWGLHCSRLDDHALTGA 624
Query: 169 KDTMVKWW 176
D+ V W
Sbjct: 625 SDSRVILW 632
Score = 47.0 bits (110), Expect = 8e-05
Identities = 57/313 (18%), Positives = 121/313 (38%), Gaps = 33/313 (10%)
Query: 414 HRSDVRTLSFSSDNIAVLSAAAD-SIKIWN---RSTLQCIRTMTCEYALCSFFVPGDRQV 469
H + V T++F + + + D ++++W+ R L +F R +
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDIVRHYGTHHFRGSPGVVHLVAFHPDPTRLL 167
Query: 470 VIGTKT-GKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELV 528
+ + T ++++ L + L + AH A+ S++ S D ++ G DK WD +
Sbjct: 168 LFSSATDAAIRVWSLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWDLQ-- 225
Query: 529 KDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVD---TLKFFL 585
S + TRT+ + E V P + + + + + TL+ +
Sbjct: 226 ----------SCQATRTVPVFESVEAAVLLPEEPVSQLGVKSPGLYFLTAGDQGTLRVWE 275
Query: 586 SLYGHKL-----------PVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDD 634
+ G + + ++H ++ T +AD N+ ++ K + +
Sbjct: 276 AASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEARSLRLQKQFAGYSE 335
Query: 635 SVMYLQFV-PKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSS 693
V+ ++F+ P+ A +K ++ Q L GH + L V G S
Sbjct: 336 EVLDVRFLGPEDSHVVVASNSPCLKVFELQT-SACQILHGHTDIVLALDVFRKGWLFASC 394
Query: 694 SHDKSLRLWERTR 706
+ D+S+R+W +
Sbjct: 395 AKDQSVRIWRMNK 407
Score = 32.3 bits (72), Expect = 2.1
Identities = 18/92 (19%), Positives = 41/92 (44%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+W L+ + +G V + G L DG ++++++ + E T + H+
Sbjct: 547 LWALQDFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNNECVRTLDAHED 606
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINES 140
+ L +L +G+ D+ +I+W + E+
Sbjct: 607 KVWGLHCSRLDDHALTGASDSRVILWKDVTEA 638
>gi|13376840 WD repeat domain 61 [Homo sapiens]
Length = 305
Score = 104 bits (259), Expect = 4e-22
Identities = 60/226 (26%), Positives = 107/226 (47%), Gaps = 11/226 (4%)
Query: 478 LQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKR 537
++L+DL +G +++IDA W+++ SPD + TG V + E K E S R
Sbjct: 88 IRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTR 147
Query: 538 LSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICM 597
+ +L ++YSP+ K LA +D + IF + T K +L GH +P+ +
Sbjct: 148 -----------GKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSL 196
Query: 598 DISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKI 657
S D L+ T S D +KI+ + + +L H V+ + F P F ++ D +
Sbjct: 197 TFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSV 256
Query: 658 KQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
K WD + T H ++W + + +G +VS D+ + +++
Sbjct: 257 KVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 91.3 bits (225), Expect = 4e-18
Identities = 50/175 (28%), Positives = 87/175 (49%)
Query: 46 HVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNG 105
H+ +WDL G++I + + L SPD +LA G G + IF + SG+ + +
Sbjct: 87 HIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDT 146
Query: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
I ++ Y G LASG+ D I ++D+ L+ L+GH I F + LLV
Sbjct: 147 RGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLV 206
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
T+ D +K +D+ + T+ GH + V + ++ ++ +SD ++VWD+
Sbjct: 207 TASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
Score = 85.9 bits (211), Expect = 2e-16
Identities = 50/173 (28%), Positives = 82/173 (47%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V I+ + G+K L + + + SPDG +LA G DG I IF + +G+ T GH
Sbjct: 130 VNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGH 189
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
I +L + L + S D I ++DV + + L GH + F + V+
Sbjct: 190 AMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVS 249
Query: 167 SGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
S D VK WD+ T+ C T H+ +VWG+ ++++ D E+ ++D
Sbjct: 250 SSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 72.8 bits (177), Expect = 1e-12
Identities = 56/255 (21%), Positives = 114/255 (44%), Gaps = 14/255 (5%)
Query: 410 TIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTMTCEY--ALCSFFVPGD 466
++ GH+ V ++ S S++ D+ I++W+ + I+++ A F P
Sbjct: 59 SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDS 118
Query: 467 RQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFE 526
+ + GT GK+ ++ + SG ++D + S++ SPD + +G D + +D
Sbjct: 119 QYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDI- 177
Query: 527 LVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLS 586
+T K L + + + +++SP+ +LL + D +KI+ V +
Sbjct: 178 ------ATGKLLHTLEGHAM----PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGT 227
Query: 587 LYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSH 646
L GH V+ + D + S+D++VK+W + C + F H D V +++
Sbjct: 228 LSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGS 287
Query: 647 LFFTAGKDHKIKQWD 661
+ G D +I +D
Sbjct: 288 KIVSVGDDQEIHIYD 302
Score = 64.3 bits (155), Expect = 5e-10
Identities = 56/223 (25%), Positives = 97/223 (43%), Gaps = 15/223 (6%)
Query: 486 GNLLETIDAHDGALWSMSLSPDQRG----FVTGGADKSVKFWDFELVKDEN-STQKRLSV 540
G L + AHD A+WS++ +++ VTG D VK W + +DE Q L
Sbjct: 6 GILFKQEQAHDDAIWSVAWGTNKKENSETVVTGSLDDLVKVWKW---RDERLDLQWSLEG 62
Query: 541 KQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDIS 600
Q V+ V S + A S LD ++++ ++ K S+ + + S
Sbjct: 63 HQL-------GVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
Query: 601 HDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW 660
D +ATG+ V I+G++ G SL ++ + + P + D I +
Sbjct: 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIF 175
Query: 661 DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
D + + TLEGH I L SP +V++S D +++++
Sbjct: 176 DIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
Score = 33.5 bits (75), Expect = 0.96
Identities = 38/171 (22%), Positives = 64/171 (37%), Gaps = 50/171 (29%)
Query: 15 VFGVIGSQK-------GNIVFVTLRGEKGRYVAVPACEHVF-IWDLRKGEKILILQGLKQ 66
+FGV +K G + G+Y+A A + + I+D+ G+ + L+G
Sbjct: 132 IFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAM 191
Query: 67 EVTCLCPSPDGLHLAVGYEDGSIRIFSL--------LSGEG----NV------------- 101
+ L SPD L +DG I+I+ + LSG NV
Sbjct: 192 PIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSS 251
Query: 102 -----------------TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWD 135
TF H+ + +KY+ G ++ S D +I ++D
Sbjct: 252 SDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Score = 33.1 bits (74), Expect = 1.3
Identities = 20/101 (19%), Positives = 43/101 (42%), Gaps = 2/101 (1%)
Query: 122 LASGSKDTDIIVWDVINE--SGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLD 179
+ +GS D + VW +E + L+GH+ + + +S D ++ WDL+
Sbjct: 35 VVTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLE 94
Query: 180 TQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
K++ + W L + + L TG ++ ++ +
Sbjct: 95 NGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGV 135
>gi|32483361 apoptotic peptidase activating factor 1 isoform d [Homo
sapiens]
Length = 1205
Score = 103 bits (257), Expect = 8e-22
Identities = 135/650 (20%), Positives = 245/650 (37%), Gaps = 123/650 (18%)
Query: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
C S DG +A D ++++F +GE + H+ + + +A+ S D +
Sbjct: 622 CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKV 681
Query: 132 IVWDVINESGLYRLKGHKDAITQALFLREKN--LLVTSGKDTMVKWWDLDTQHCFKTMVG 189
+W+ + ++ H + + F + LL T D +K WDL+ + C TM G
Sbjct: 682 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 741
Query: 190 HRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQE------------IEDPEEPDPKKI 237
H V ++K L + ++D L++WD E +EDP+E +
Sbjct: 742 HTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIV 801
Query: 238 K---GSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRIL 294
K S+ G + + A++ F + ++ CR G +
Sbjct: 802 KCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCR---------------------GHLS 840
Query: 295 ACHGTDSVLELFCILSKKEIQK-KMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEI 353
HG + L+ + Q ++ + K + A + + + E V + D I
Sbjct: 841 WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 900
Query: 354 QRVTNIK---------TSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPV 404
+R+ I T A++ L SPH + A F +N +E+ L +
Sbjct: 901 RRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIA-FGDENGAIEILEL-----VNNRI 952
Query: 405 RTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTMTCEYALCSFFV 463
SR H+ V + F++D ++S++ D+ I++WN +CI + + F +
Sbjct: 953 FQSRFQ---HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL 1009
Query: 464 PGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFW 523
+ +++ + G ++++++ +GN + H G + S +S D F + ADK+ K W
Sbjct: 1010 LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Query: 524 DFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKF 583
F+L+ L L E
Sbjct: 1070 SFDLL-----------------LPLHE--------------------------------- 1079
Query: 584 FLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGD--------CHKSLFAHDDS 635
L GH V C S D L+ATG + ++IW + G+ + H
Sbjct: 1080 ---LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1136
Query: 636 VMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSP 685
V L F P + +AG IK W+ E QT + + + VSP
Sbjct: 1137 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1184
Score = 73.2 bits (178), Expect = 1e-12
Identities = 47/170 (27%), Positives = 85/170 (50%), Gaps = 13/170 (7%)
Query: 495 HDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLC 554
H A++ S D + + GADK+++ + E + +K L +K +++VLC
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAE------TGEKLLEIKAH-----EDEVLC 662
Query: 555 VSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDG--ALIATGSAD 612
++S + + +A +D VKI+ T + + H V C ++ L+ATGS+D
Sbjct: 663 CAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSD 722
Query: 613 RNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDA 662
+K+W L+ +C ++F H +SV + +F P L + D +K WDA
Sbjct: 723 CFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 772
Score = 72.8 bits (177), Expect = 1e-12
Identities = 46/151 (30%), Positives = 71/151 (47%), Gaps = 2/151 (1%)
Query: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVK 616
+S + + +A D T+++F +T + L + H+ V+C S D IAT S D+ VK
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 617 IWGLDFGDCHKSLFAHDDSVMYLQFVPKSH--LFFTAGKDHKIKQWDADKFEHIQTLEGH 674
IW G+ + H + V F SH L T D +K WD ++ E T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705
+ SP + S S D +L+LW+ T
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Score = 72.0 bits (175), Expect = 2e-12
Identities = 65/245 (26%), Positives = 105/245 (42%), Gaps = 35/245 (14%)
Query: 478 LQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDF---ELVK--DEN 532
LQ++ +G L I AH+ + + S D R T DK VK W+ ELV DE+
Sbjct: 639 LQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEH 698
Query: 533 STQKRLSVKQTRTLQLDEDVLCVSY--SPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590
S E V C + S + LLA DC +K++ ++ + +++GH
Sbjct: 699 S----------------EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAH------DDSVMYLQFVPK 644
V S D L+A+ SAD +K+W + KS+ +D ++ + K
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVK 802
Query: 645 SHLFFTAGK------DHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698
+ G +KI W+ D + GH + + SP G ++SS D++
Sbjct: 803 CCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 862
Query: 699 LRLWE 703
+RLWE
Sbjct: 863 IRLWE 867
Score = 68.6 bits (166), Expect = 3e-11
Identities = 97/480 (20%), Positives = 192/480 (40%), Gaps = 71/480 (14%)
Query: 274 IMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHS 333
++R D V + + G+ +A G D L++F K E +K+ + KA + L
Sbjct: 610 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVF----KAETGEKLLEI--KAHEDEVLCC 663
Query: 334 SKGEEE--------DPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQ 385
+ ++ D +V + S+ E+ T + S ++ +S H L A
Sbjct: 664 AFSTDDRFIATCSVDKKVKIWNSMTGELVH-TYDEHSEQVNCCHFTNSSHHLLLATGS-S 721
Query: 386 NNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRS 444
+ ++L+ LN + R T+ GH + V FS D+ + S +AD ++K+W+ +
Sbjct: 722 DCFLKLWDLNQ--------KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Query: 445 TLQCIRTMTCEYAL----------------CSFFVPGDRQVVIGTKTGKLQLYDLASGNL 488
+ +++ + CS+ G R +++ K K+ L++ S +
Sbjct: 774 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGAR-IMVAAKN-KIFLWNTDSRSK 831
Query: 489 LETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFW---------------DFELVKDENS 533
+ H + + SPD F+T D++++ W + ++V EN
Sbjct: 832 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE 891
Query: 534 TQ-------KRLSVKQTRTLQLD----EDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLK 582
+RL + RT Q+D V C SP+ + +A + ++I + +
Sbjct: 892 VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 951
Query: 583 FFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFV 642
F S + HK V + + D + + S D +++W C L H ++V + +
Sbjct: 952 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLL 1010
Query: 643 PKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
S L + D +K W+ + H + +S S+S DK+ ++W
Sbjct: 1011 KNSRL-LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Score = 60.5 bits (145), Expect = 7e-09
Identities = 47/190 (24%), Positives = 87/190 (45%), Gaps = 2/190 (1%)
Query: 39 VAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGE 98
V V A +H+ L G I + +V+C C SP ++A G E+G+I I L++
Sbjct: 892 VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 951
Query: 99 GNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFL 158
+ HK + +++ L S S D +I VW+ + ++ L+GH++ + L
Sbjct: 952 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL 1010
Query: 159 REKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
+ LL S D VK W++ T + K V H+ V + + + + ++D ++W
Sbjct: 1011 KNSRLLSWS-FDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1069
Query: 219 DIAYLQEIED 228
L + +
Sbjct: 1070 SFDLLLPLHE 1079
Score = 53.5 bits (127), Expect = 9e-07
Identities = 101/554 (18%), Positives = 197/554 (35%), Gaps = 112/554 (20%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
++ GEK+L ++ + EV C S D +A D ++I++ ++GE T++ H
Sbjct: 641 VFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 700
Query: 109 AITTLKYDQLGGRL--ASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+ + L A+GS D + +WD+ + + GH +++ F + LL +
Sbjct: 701 QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLAS 760
Query: 167 SGKDTMVKWWDL-------------------DTQHCFKTMV------------------- 188
D +K WD D Q + +V
Sbjct: 761 CSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK 820
Query: 189 ----------------GHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEP 232
GH + V G++ + +T + D +R+W+
Sbjct: 821 IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE------------- 867
Query: 233 DPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRI----LSCRKAGSIMREGRDRVVNLAVD 288
K K S+ ++ ++ E D I L + G I +V +
Sbjct: 868 TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLS 927
Query: 289 KTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMS 348
+ +A + +E+ +++ + Q + KK H +E ++ S
Sbjct: 928 PHLQYIAFGDENGAIEILELVNNRIFQSRFQ------HKKTVWHIQFTADEKTLIS---S 978
Query: 349 LQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSR 408
D +V N + I + +K LL+N+ + +S + + V+
Sbjct: 979 SDDAEIQVWNWQLDKCI----FLRGHQETVKDFRLLKNSRLLSWSFDGT------VKVWN 1028
Query: 409 ITIGGHRSD-------VRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYAL-- 458
I G D V + S D S +AD + KIW+ L + +
Sbjct: 1029 IITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1088
Query: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLL--------ETIDAHDGALWSMSLSPDQRG 510
CS F + G G+++++++++G LL E H G + + SPD +
Sbjct: 1089 CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKM 1148
Query: 511 FVTGGADKSVKFWD 524
++ G +K+W+
Sbjct: 1149 LISAGG--YIKWWN 1160
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/88 (21%), Positives = 39/88 (44%)
Query: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVV 691
H D+V + F + G D ++ + A+ E + ++ H E+ C A S ++
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 692 SSSHDKSLRLWERTREPLILEEEREMER 719
+ S DK +++W L+ + E+
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQ 701
Score = 39.7 bits (91), Expect = 0.013
Identities = 26/132 (19%), Positives = 60/132 (45%), Gaps = 4/132 (3%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V+ W L +K + L+G ++ V + L+ + DG+++++++++G F H
Sbjct: 986 VWNWQL---DKCIFLRGHQETVKDFRLLKNSRLLSWSF-DGTVKVWNIITGNKEKDFVCH 1041
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+ + + + +S S D +W L+ L+GH + + F + LL T
Sbjct: 1042 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1101
Query: 167 SGKDTMVKWWDL 178
+ ++ W++
Sbjct: 1102 GDDNGEIRIWNV 1113
Score = 32.3 bits (72), Expect = 2.1
Identities = 18/97 (18%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Query: 128 DTDIIVWDVINESGLYRL-----KGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQH 182
D ++ + IN+ + L + H DA+ A F + + + G D ++ + +T
Sbjct: 589 DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 648
Query: 183 CFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
+ H EV ++++ + T + D ++++W+
Sbjct: 649 KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWN 685
Score = 31.2 bits (69), Expect = 4.8
Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 10/112 (8%)
Query: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLY--------RLKGHKDAITQAL 156
GH + + LA+G + +I +W+V N L+ H +T
Sbjct: 1082 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1141
Query: 157 FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLIT 208
F + +L+++G +KWW++ T +T + T + + + + K +T
Sbjct: 1142 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1191
>gi|4502123 apoptotic peptidase activating factor 1 isoform b [Homo
sapiens]
Length = 1194
Score = 103 bits (257), Expect = 8e-22
Identities = 135/650 (20%), Positives = 245/650 (37%), Gaps = 123/650 (18%)
Query: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
C S DG +A D ++++F +GE + H+ + + +A+ S D +
Sbjct: 611 CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKV 670
Query: 132 IVWDVINESGLYRLKGHKDAITQALFLREKN--LLVTSGKDTMVKWWDLDTQHCFKTMVG 189
+W+ + ++ H + + F + LL T D +K WDL+ + C TM G
Sbjct: 671 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 730
Query: 190 HRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQE------------IEDPEEPDPKKI 237
H V ++K L + ++D L++WD E +EDP+E +
Sbjct: 731 HTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIV 790
Query: 238 K---GSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRIL 294
K S+ G + + A++ F + ++ CR G +
Sbjct: 791 KCCSWSADGARIMVAAKNKIFLWNTDSRSKVADCR---------------------GHLS 829
Query: 295 ACHGTDSVLELFCILSKKEIQK-KMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEI 353
HG + L+ + Q ++ + K + A + + + E V + D I
Sbjct: 830 WVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHI 889
Query: 354 QRVTNIK---------TSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPV 404
+R+ I T A++ L SPH + A F +N +E+ L +
Sbjct: 890 RRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIA-FGDENGAIEILEL-----VNNRI 941
Query: 405 RTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTMTCEYALCSFFV 463
SR H+ V + F++D ++S++ D+ I++WN +CI + + F +
Sbjct: 942 FQSRFQ---HKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRL 998
Query: 464 PGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFW 523
+ +++ + G ++++++ +GN + H G + S +S D F + ADK+ K W
Sbjct: 999 LKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1058
Query: 524 DFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKF 583
F+L+ L L E
Sbjct: 1059 SFDLL-----------------LPLHE--------------------------------- 1068
Query: 584 FLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGD--------CHKSLFAHDDS 635
L GH V C S D L+ATG + ++IW + G+ + H
Sbjct: 1069 ---LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGW 1125
Query: 636 VMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSP 685
V L F P + +AG IK W+ E QT + + + VSP
Sbjct: 1126 VTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSP 1173
Score = 73.2 bits (178), Expect = 1e-12
Identities = 47/170 (27%), Positives = 85/170 (50%), Gaps = 13/170 (7%)
Query: 495 HDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLC 554
H A++ S D + + GADK+++ + E + +K L +K +++VLC
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAE------TGEKLLEIKAH-----EDEVLC 651
Query: 555 VSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDG--ALIATGSAD 612
++S + + +A +D VKI+ T + + H V C ++ L+ATGS+D
Sbjct: 652 CAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSD 711
Query: 613 RNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDA 662
+K+W L+ +C ++F H +SV + +F P L + D +K WDA
Sbjct: 712 CFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDA 761
Score = 72.8 bits (177), Expect = 1e-12
Identities = 46/151 (30%), Positives = 71/151 (47%), Gaps = 2/151 (1%)
Query: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVK 616
+S + + +A D T+++F +T + L + H+ V+C S D IAT S D+ VK
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 617 IWGLDFGDCHKSLFAHDDSVMYLQFVPKSH--LFFTAGKDHKIKQWDADKFEHIQTLEGH 674
IW G+ + H + V F SH L T D +K WD ++ E T+ GH
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705
+ SP + S S D +L+LW+ T
Sbjct: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Score = 72.0 bits (175), Expect = 2e-12
Identities = 65/245 (26%), Positives = 105/245 (42%), Gaps = 35/245 (14%)
Query: 478 LQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDF---ELVK--DEN 532
LQ++ +G L I AH+ + + S D R T DK VK W+ ELV DE+
Sbjct: 628 LQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEH 687
Query: 533 STQKRLSVKQTRTLQLDEDVLCVSY--SPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590
S E V C + S + LLA DC +K++ ++ + +++GH
Sbjct: 688 S----------------EQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAH------DDSVMYLQFVPK 644
V S D L+A+ SAD +K+W + KS+ +D ++ + K
Sbjct: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVK 791
Query: 645 SHLFFTAGK------DHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698
+ G +KI W+ D + GH + + SP G ++SS D++
Sbjct: 792 CCSWSADGARIMVAAKNKIFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 851
Query: 699 LRLWE 703
+RLWE
Sbjct: 852 IRLWE 856
Score = 68.6 bits (166), Expect = 3e-11
Identities = 97/480 (20%), Positives = 192/480 (40%), Gaps = 71/480 (14%)
Query: 274 IMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHS 333
++R D V + + G+ +A G D L++F K E +K+ + KA + L
Sbjct: 599 VVRPHTDAVYHACFSEDGQRIASCGADKTLQVF----KAETGEKLLEI--KAHEDEVLCC 652
Query: 334 SKGEEE--------DPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQ 385
+ ++ D +V + S+ E+ T + S ++ +S H L A
Sbjct: 653 AFSTDDRFIATCSVDKKVKIWNSMTGELVH-TYDEHSEQVNCCHFTNSSHHLLLATGS-S 710
Query: 386 NNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRS 444
+ ++L+ LN + R T+ GH + V FS D+ + S +AD ++K+W+ +
Sbjct: 711 DCFLKLWDLNQ--------KECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Query: 445 TLQCIRTMTCEYAL----------------CSFFVPGDRQVVIGTKTGKLQLYDLASGNL 488
+ +++ + CS+ G R +++ K K+ L++ S +
Sbjct: 763 SANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGAR-IMVAAKN-KIFLWNTDSRSK 820
Query: 489 LETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFW---------------DFELVKDENS 533
+ H + + SPD F+T D++++ W + ++V EN
Sbjct: 821 VADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENE 880
Query: 534 TQ-------KRLSVKQTRTLQLD----EDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLK 582
+RL + RT Q+D V C SP+ + +A + ++I + +
Sbjct: 881 VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 940
Query: 583 FFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFV 642
F S + HK V + + D + + S D +++W C L H ++V + +
Sbjct: 941 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKC-IFLRGHQETVKDFRLL 999
Query: 643 PKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
S L + D +K W+ + H + +S S+S DK+ ++W
Sbjct: 1000 KNSRL-LSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1058
Score = 60.5 bits (145), Expect = 7e-09
Identities = 47/190 (24%), Positives = 87/190 (45%), Gaps = 2/190 (1%)
Query: 39 VAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGE 98
V V A +H+ L G I + +V+C C SP ++A G E+G+I I L++
Sbjct: 881 VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 940
Query: 99 GNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFL 158
+ HK + +++ L S S D +I VW+ + ++ L+GH++ + L
Sbjct: 941 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL 999
Query: 159 REKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
+ LL S D VK W++ T + K V H+ V + + + + ++D ++W
Sbjct: 1000 KNSRLLSWS-FDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1058
Query: 219 DIAYLQEIED 228
L + +
Sbjct: 1059 SFDLLLPLHE 1068
Score = 53.5 bits (127), Expect = 9e-07
Identities = 101/554 (18%), Positives = 197/554 (35%), Gaps = 112/554 (20%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
++ GEK+L ++ + EV C S D +A D ++I++ ++GE T++ H
Sbjct: 630 VFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 689
Query: 109 AITTLKYDQLGGRL--ASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+ + L A+GS D + +WD+ + + GH +++ F + LL +
Sbjct: 690 QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLAS 749
Query: 167 SGKDTMVKWWDL-------------------DTQHCFKTMV------------------- 188
D +K WD D Q + +V
Sbjct: 750 CSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK 809
Query: 189 ----------------GHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEP 232
GH + V G++ + +T + D +R+W+
Sbjct: 810 IFLWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWE------------- 856
Query: 233 DPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRI----LSCRKAGSIMREGRDRVVNLAVD 288
K K S+ ++ ++ E D I L + G I +V +
Sbjct: 857 TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLS 916
Query: 289 KTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMS 348
+ +A + +E+ +++ + Q + KK H +E ++ S
Sbjct: 917 PHLQYIAFGDENGAIEILELVNNRIFQSRFQ------HKKTVWHIQFTADEKTLIS---S 967
Query: 349 LQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSR 408
D +V N + I + +K LL+N+ + +S + + V+
Sbjct: 968 SDDAEIQVWNWQLDKCI----FLRGHQETVKDFRLLKNSRLLSWSFDGT------VKVWN 1017
Query: 409 ITIGGHRSD-------VRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYAL-- 458
I G D V + S D S +AD + KIW+ L + +
Sbjct: 1018 IITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVR 1077
Query: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLL--------ETIDAHDGALWSMSLSPDQRG 510
CS F + G G+++++++++G LL E H G + + SPD +
Sbjct: 1078 CSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKM 1137
Query: 511 FVTGGADKSVKFWD 524
++ G +K+W+
Sbjct: 1138 LISAGG--YIKWWN 1149
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/88 (21%), Positives = 39/88 (44%)
Query: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVV 691
H D+V + F + G D ++ + A+ E + ++ H E+ C A S ++
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 692 SSSHDKSLRLWERTREPLILEEEREMER 719
+ S DK +++W L+ + E+
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQ 690
Score = 39.7 bits (91), Expect = 0.013
Identities = 26/132 (19%), Positives = 60/132 (45%), Gaps = 4/132 (3%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V+ W L +K + L+G ++ V + L+ + DG+++++++++G F H
Sbjct: 975 VWNWQL---DKCIFLRGHQETVKDFRLLKNSRLLSWSF-DGTVKVWNIITGNKEKDFVCH 1030
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+ + + + +S S D +W L+ L+GH + + F + LL T
Sbjct: 1031 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1090
Query: 167 SGKDTMVKWWDL 178
+ ++ W++
Sbjct: 1091 GDDNGEIRIWNV 1102
Score = 32.3 bits (72), Expect = 2.1
Identities = 18/97 (18%), Positives = 44/97 (45%), Gaps = 5/97 (5%)
Query: 128 DTDIIVWDVINESGLYRL-----KGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQH 182
D ++ + IN+ + L + H DA+ A F + + + G D ++ + +T
Sbjct: 578 DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 637
Query: 183 CFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
+ H EV ++++ + T + D ++++W+
Sbjct: 638 KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWN 674
Score = 31.2 bits (69), Expect = 4.8
Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 10/112 (8%)
Query: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLY--------RLKGHKDAITQAL 156
GH + + LA+G + +I +W+V N L+ H +T
Sbjct: 1071 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1130
Query: 157 FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLIT 208
F + +L+++G +KWW++ T +T + T + + + + K +T
Sbjct: 1131 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1180
>gi|48928050 F-box and WD repeat domain containing 11 isoform C
[Homo sapiens]
Length = 542
Score = 99.0 bits (245), Expect = 2e-20
Identities = 72/299 (24%), Positives = 140/299 (46%), Gaps = 28/299 (9%)
Query: 426 DNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484
D+ ++S D SIKIW++++L+C++ +T +R +V G+ ++++D+
Sbjct: 249 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 308
Query: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544
+G +L T+ H+ A+ + S VT D+S+ WD D T +R+ V
Sbjct: 309 TGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATD--ITLRRVLVGHRA 364
Query: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604
+ + + + K + + D T+K++ T +F +L GHK + C+ +
Sbjct: 365 AVNVVDF--------DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQ--YRDR 414
Query: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
L+ +GS+D +++W ++ G C + L H++ V ++F K + D KIK WD
Sbjct: 415 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQA 472
Query: 665 FEH---------IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714
++TL H ++ L ++SSSHD ++ +W+ P + E
Sbjct: 473 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWDFLNVPPSAQNE 529
Score = 74.3 bits (181), Expect = 5e-13
Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 16/190 (8%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
IWD E + +L G V CL D + G D ++R++ + +GE T H
Sbjct: 264 IWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNE 321
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR---LKGHKDAITQALFLREKNLLV 165
A+ L++ G + + SKD I VWD+ + + + L GH+ A+ F + +V
Sbjct: 322 AVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 377
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRL-ITGASDSELRVWDI---A 221
++ D +K W T +T+ GH+ G+ L RL ++G+SD+ +R+WDI A
Sbjct: 378 SASGDRTIKVWSTSTCEFVRTLNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDIECGA 434
Query: 222 YLQEIEDPEE 231
L+ +E EE
Sbjct: 435 CLRVLEGHEE 444
Score = 72.4 bits (176), Expect = 2e-12
Identities = 46/154 (29%), Positives = 84/154 (54%), Gaps = 11/154 (7%)
Query: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611
V C+ Y ++K+++ L D ++KI+ +L+ L GH V+C+ +D +I TGS+
Sbjct: 243 VYCLQYD-DEKIIS-GLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSS 298
Query: 612 DRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHI--- 668
D V++W ++ G+ +L H+++V++L+F + L T KD I WD I
Sbjct: 299 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLR 356
Query: 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
+ L GH + V Y+VS+S D+++++W
Sbjct: 357 RVLVGHRAAV--NVVDFDDKYIVSASGDRTIKVW 388
Score = 68.9 bits (167), Expect = 2e-11
Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 22/203 (10%)
Query: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKL 563
L D ++G D S+K WD ++ + L V T VLC+ Y ++++
Sbjct: 246 LQYDDEKIISGLRDNSIKIWD-------KTSLECLKVLTGHT----GSVLCLQY--DERV 292
Query: 564 LAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFG 623
+ D TV+++ V+T + +L H V+ + S+ L+ T S DR++ +W +
Sbjct: 293 IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASA 350
Query: 624 ---DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWC 680
+ L H +V + F K +A D IK W E ++TL GH + I C
Sbjct: 351 TDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC 408
Query: 681 LAVSPSGDYVVSSSHDKSLRLWE 703
L VVS S D ++RLW+
Sbjct: 409 LQYRDR--LVVSGSSDNTIRLWD 429
Score = 68.9 bits (167), Expect = 2e-11
Identities = 56/190 (29%), Positives = 92/190 (48%), Gaps = 16/190 (8%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-- 104
V +WD+ GE + L + V L S +GL + +D SI ++ + S ++T
Sbjct: 302 VRVWDVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTCS-KDRSIAVWDMASAT-DITLRRV 358
Query: 105 --GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
GH+AA+ + +D + S S D I VW + L GHK I L R++
Sbjct: 359 LVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA-CLQYRDR- 414
Query: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAY 222
L+V+ D ++ WD++ C + + GH V + + KR+++GA D +++VWD
Sbjct: 415 LVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWD--- 469
Query: 223 LQEIEDPEEP 232
LQ DP P
Sbjct: 470 LQAALDPRAP 479
Score = 63.2 bits (152), Expect = 1e-09
Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 9/150 (6%)
Query: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
C D + G D SI+I+ S E GH ++ L+YD+ + +GS D+ +
Sbjct: 245 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTV 302
Query: 132 IVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF---KTMV 188
VWDV L L H +A+ F L+VT KD + WD+ + + +V
Sbjct: 303 RVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLRRVLV 360
Query: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVW 218
GHR V V+ ++K +++ + D ++VW
Sbjct: 361 GHRAAV--NVVDFDDKYIVSASGDRTIKVW 388
Score = 52.8 bits (125), Expect = 2e-06
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 6/114 (5%)
Query: 113 LKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTM 172
L+YD ++ SG +D I +WD + L L GH ++ + ++ ++VT D+
Sbjct: 246 LQYDD--EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDST 301
Query: 173 VKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI 226
V+ WD++T T++ H V L L ++T + D + VWD+A +I
Sbjct: 302 VRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDI 353
>gi|48928048 F-box and WD repeat domain containing 11 isoform A
[Homo sapiens]
Length = 508
Score = 99.0 bits (245), Expect = 2e-20
Identities = 72/299 (24%), Positives = 140/299 (46%), Gaps = 28/299 (9%)
Query: 426 DNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484
D+ ++S D SIKIW++++L+C++ +T +R +V G+ ++++D+
Sbjct: 215 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 274
Query: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544
+G +L T+ H+ A+ + S VT D+S+ WD D T +R+ V
Sbjct: 275 TGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATD--ITLRRVLVGHRA 330
Query: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604
+ + + + K + + D T+K++ T +F +L GHK + C+ +
Sbjct: 331 AVNVVDF--------DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQ--YRDR 380
Query: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
L+ +GS+D +++W ++ G C + L H++ V ++F K + D KIK WD
Sbjct: 381 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQA 438
Query: 665 FEH---------IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714
++TL H ++ L ++SSSHD ++ +W+ P + E
Sbjct: 439 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWDFLNVPPSAQNE 495
Score = 74.3 bits (181), Expect = 5e-13
Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 16/190 (8%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
IWD E + +L G V CL D + G D ++R++ + +GE T H
Sbjct: 230 IWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNE 287
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR---LKGHKDAITQALFLREKNLLV 165
A+ L++ G + + SKD I VWD+ + + + L GH+ A+ F + +V
Sbjct: 288 AVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 343
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRL-ITGASDSELRVWDI---A 221
++ D +K W T +T+ GH+ G+ L RL ++G+SD+ +R+WDI A
Sbjct: 344 SASGDRTIKVWSTSTCEFVRTLNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDIECGA 400
Query: 222 YLQEIEDPEE 231
L+ +E EE
Sbjct: 401 CLRVLEGHEE 410
Score = 72.4 bits (176), Expect = 2e-12
Identities = 46/154 (29%), Positives = 84/154 (54%), Gaps = 11/154 (7%)
Query: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611
V C+ Y ++K+++ L D ++KI+ +L+ L GH V+C+ +D +I TGS+
Sbjct: 209 VYCLQYD-DEKIIS-GLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSS 264
Query: 612 DRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHI--- 668
D V++W ++ G+ +L H+++V++L+F + L T KD I WD I
Sbjct: 265 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLR 322
Query: 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
+ L GH + V Y+VS+S D+++++W
Sbjct: 323 RVLVGHRAAV--NVVDFDDKYIVSASGDRTIKVW 354
Score = 68.9 bits (167), Expect = 2e-11
Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 22/203 (10%)
Query: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKL 563
L D ++G D S+K WD ++ + L V T VLC+ Y ++++
Sbjct: 212 LQYDDEKIISGLRDNSIKIWD-------KTSLECLKVLTGHT----GSVLCLQY--DERV 258
Query: 564 LAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFG 623
+ D TV+++ V+T + +L H V+ + S+ L+ T S DR++ +W +
Sbjct: 259 IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASA 316
Query: 624 ---DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWC 680
+ L H +V + F K +A D IK W E ++TL GH + I C
Sbjct: 317 TDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC 374
Query: 681 LAVSPSGDYVVSSSHDKSLRLWE 703
L VVS S D ++RLW+
Sbjct: 375 LQYRDR--LVVSGSSDNTIRLWD 395
Score = 68.9 bits (167), Expect = 2e-11
Identities = 56/190 (29%), Positives = 92/190 (48%), Gaps = 16/190 (8%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-- 104
V +WD+ GE + L + V L S +GL + +D SI ++ + S ++T
Sbjct: 268 VRVWDVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTCS-KDRSIAVWDMASAT-DITLRRV 324
Query: 105 --GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
GH+AA+ + +D + S S D I VW + L GHK I L R++
Sbjct: 325 LVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA-CLQYRDR- 380
Query: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAY 222
L+V+ D ++ WD++ C + + GH V + + KR+++GA D +++VWD
Sbjct: 381 LVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWD--- 435
Query: 223 LQEIEDPEEP 232
LQ DP P
Sbjct: 436 LQAALDPRAP 445
Score = 63.2 bits (152), Expect = 1e-09
Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 9/150 (6%)
Query: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
C D + G D SI+I+ S E GH ++ L+YD+ + +GS D+ +
Sbjct: 211 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTV 268
Query: 132 IVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF---KTMV 188
VWDV L L H +A+ F L+VT KD + WD+ + + +V
Sbjct: 269 RVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLRRVLV 326
Query: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVW 218
GHR V V+ ++K +++ + D ++VW
Sbjct: 327 GHRAAV--NVVDFDDKYIVSASGDRTIKVW 354
Score = 52.8 bits (125), Expect = 2e-06
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 6/114 (5%)
Query: 113 LKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTM 172
L+YD ++ SG +D I +WD + L L GH ++ + ++ ++VT D+
Sbjct: 212 LQYDD--EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDST 267
Query: 173 VKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI 226
V+ WD++T T++ H V L L ++T + D + VWD+A +I
Sbjct: 268 VRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDI 319
>gi|48928046 F-box and WD repeat domain containing 11 isoform B
[Homo sapiens]
Length = 529
Score = 99.0 bits (245), Expect = 2e-20
Identities = 72/299 (24%), Positives = 140/299 (46%), Gaps = 28/299 (9%)
Query: 426 DNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484
D+ ++S D SIKIW++++L+C++ +T +R +V G+ ++++D+
Sbjct: 236 DDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDERVIVTGSSDSTVRVWDVN 295
Query: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544
+G +L T+ H+ A+ + S VT D+S+ WD D T +R+ V
Sbjct: 296 TGEVLNTLIHHNEAVLHLRFSNGL--MVTCSKDRSIAVWDMASATD--ITLRRVLVGHRA 351
Query: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604
+ + + + K + + D T+K++ T +F +L GHK + C+ +
Sbjct: 352 AVNVVDF--------DDKYIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIACLQ--YRDR 401
Query: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
L+ +GS+D +++W ++ G C + L H++ V ++F K + D KIK WD
Sbjct: 402 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLQA 459
Query: 665 FEH---------IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEE 714
++TL H ++ L ++SSSHD ++ +W+ P + E
Sbjct: 460 ALDPRAPASTLCLRTLVEHSGRVFRLQFDEF--QIISSSHDDTILIWDFLNVPPSAQNE 516
Score = 74.3 bits (181), Expect = 5e-13
Identities = 56/190 (29%), Positives = 93/190 (48%), Gaps = 16/190 (8%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
IWD E + +L G V CL D + G D ++R++ + +GE T H
Sbjct: 251 IWDKTSLECLKVLTGHTGSVLCL--QYDERVIVTGSSDSTVRVWDVNTGEVLNTLIHHNE 308
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR---LKGHKDAITQALFLREKNLLV 165
A+ L++ G + + SKD I VWD+ + + + L GH+ A+ F + +V
Sbjct: 309 AVLHLRFS--NGLMVTCSKDRSIAVWDMASATDITLRRVLVGHRAAVNVVDF--DDKYIV 364
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRL-ITGASDSELRVWDI---A 221
++ D +K W T +T+ GH+ G+ L RL ++G+SD+ +R+WDI A
Sbjct: 365 SASGDRTIKVWSTSTCEFVRTLNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDIECGA 421
Query: 222 YLQEIEDPEE 231
L+ +E EE
Sbjct: 422 CLRVLEGHEE 431
Score = 72.4 bits (176), Expect = 2e-12
Identities = 46/154 (29%), Positives = 84/154 (54%), Gaps = 11/154 (7%)
Query: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611
V C+ Y ++K+++ L D ++KI+ +L+ L GH V+C+ +D +I TGS+
Sbjct: 230 VYCLQYD-DEKIIS-GLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQ--YDERVIVTGSS 285
Query: 612 DRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHI--- 668
D V++W ++ G+ +L H+++V++L+F + L T KD I WD I
Sbjct: 286 DSTVRVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLR 343
Query: 669 QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
+ L GH + V Y+VS+S D+++++W
Sbjct: 344 RVLVGHRAAV--NVVDFDDKYIVSASGDRTIKVW 375
Score = 68.9 bits (167), Expect = 2e-11
Identities = 56/203 (27%), Positives = 92/203 (45%), Gaps = 22/203 (10%)
Query: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKL 563
L D ++G D S+K WD ++ + L V T VLC+ Y ++++
Sbjct: 233 LQYDDEKIISGLRDNSIKIWD-------KTSLECLKVLTGHT----GSVLCLQY--DERV 279
Query: 564 LAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFG 623
+ D TV+++ V+T + +L H V+ + S+ L+ T S DR++ +W +
Sbjct: 280 IVTGSSDSTVRVWDVNTGEVLNTLIHHNEAVLHLRFSN--GLMVTCSKDRSIAVWDMASA 337
Query: 624 ---DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWC 680
+ L H +V + F K +A D IK W E ++TL GH + I C
Sbjct: 338 TDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIAC 395
Query: 681 LAVSPSGDYVVSSSHDKSLRLWE 703
L VVS S D ++RLW+
Sbjct: 396 LQYRDR--LVVSGSSDNTIRLWD 416
Score = 68.9 bits (167), Expect = 2e-11
Identities = 56/190 (29%), Positives = 92/190 (48%), Gaps = 16/190 (8%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-- 104
V +WD+ GE + L + V L S +GL + +D SI ++ + S ++T
Sbjct: 289 VRVWDVNTGEVLNTLIHHNEAVLHLRFS-NGLMVTCS-KDRSIAVWDMASAT-DITLRRV 345
Query: 105 --GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
GH+AA+ + +D + S S D I VW + L GHK I L R++
Sbjct: 346 LVGHRAAVNVVDFDDK--YIVSASGDRTIKVWSTSTCEFVRTLNGHKRGIA-CLQYRDR- 401
Query: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAY 222
L+V+ D ++ WD++ C + + GH V + + KR+++GA D +++VWD
Sbjct: 402 LVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWD--- 456
Query: 223 LQEIEDPEEP 232
LQ DP P
Sbjct: 457 LQAALDPRAP 466
Score = 63.2 bits (152), Expect = 1e-09
Identities = 43/150 (28%), Positives = 71/150 (47%), Gaps = 9/150 (6%)
Query: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
C D + G D SI+I+ S E GH ++ L+YD+ + +GS D+ +
Sbjct: 232 CLQYDDEKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQYDE--RVIVTGSSDSTV 289
Query: 132 IVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF---KTMV 188
VWDV L L H +A+ F L+VT KD + WD+ + + +V
Sbjct: 290 RVWDVNTGEVLNTLIHHNEAVLHLRF--SNGLMVTCSKDRSIAVWDMASATDITLRRVLV 347
Query: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVW 218
GHR V V+ ++K +++ + D ++VW
Sbjct: 348 GHRAAV--NVVDFDDKYIVSASGDRTIKVW 375
Score = 52.8 bits (125), Expect = 2e-06
Identities = 32/114 (28%), Positives = 57/114 (50%), Gaps = 6/114 (5%)
Query: 113 LKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTM 172
L+YD ++ SG +D I +WD + L L GH ++ + ++ ++VT D+
Sbjct: 233 LQYDD--EKIISGLRDNSIKIWDKTSLECLKVLTGHTGSVLCLQY--DERVIVTGSSDST 288
Query: 173 VKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI 226
V+ WD++T T++ H V L L ++T + D + VWD+A +I
Sbjct: 289 VRVWDVNTGEVLNTLIHHNEAV--LHLRFSNGLMVTCSKDRSIAVWDMASATDI 340
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 96.7 bits (239), Expect = 9e-20
Identities = 69/252 (27%), Positives = 116/252 (46%), Gaps = 18/252 (7%)
Query: 462 FVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVK 521
F P + + + ++ G +T+ H+ + ++ S D V+ DK++K
Sbjct: 49 FSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLK 108
Query: 522 FWDFELVKDENSTQKRLSVKQTRTLQLDED-VLCVSYSPNQKLLAVSLLDCTVKIFYVDT 580
WD S K +TL+ + V C +++P L+ D TVKI+ V T
Sbjct: 109 LWDVR------------SGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
Query: 581 LKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDS-VMYL 639
K +L H PV + + G+LI +GS D +IW G C K+L D+ V ++
Sbjct: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 640 QFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPS---GDYVVSSSHD 696
+F P TA D+ +K WD + ++T GH E +C+ + S G ++VS S D
Sbjct: 217 KFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSED 276
Query: 697 KSLRLWE-RTRE 707
+ +W +T+E
Sbjct: 277 NLVYIWNLQTKE 288
Score = 87.4 bits (215), Expect = 6e-17
Identities = 66/261 (25%), Positives = 123/261 (47%), Gaps = 22/261 (8%)
Query: 410 TIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMT--CEYALCSFFVPGD 466
T+ GH ++ +++SSD+ ++SA+ D ++K+W+ + +C++T+ Y C F P
Sbjct: 78 TLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPS 137
Query: 467 RQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFE 526
++ G+ ++++++ +G L+T+ AH + ++ + V+G D + WD
Sbjct: 138 NLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWD-- 195
Query: 527 LVKDENSTQKRLSVKQTRTLQLDED--VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFF 584
S + +TL D++ V V +SPN K + + LD T+K++ +
Sbjct: 196 ----------AASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCL 245
Query: 585 LSLYGHKLPVICMDISHD---GALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQF 641
+ GHK C+ + G I +GS D V IW L + + L H D V+
Sbjct: 246 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAAC 305
Query: 642 VPKSHLFFTAG--KDHKIKQW 660
P +L +A D IK W
Sbjct: 306 HPTENLIASAALENDKTIKLW 326
Score = 85.1 bits (209), Expect = 3e-16
Identities = 59/217 (27%), Positives = 104/217 (47%), Gaps = 12/217 (5%)
Query: 491 TIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDE 550
T+ H A+ S+ SP+ + AD+ + W K E + L++ +
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGH-------NLEISD 88
Query: 551 DVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGS 610
V++S + L + D T+K++ V + K +L GH V C + + LI +GS
Sbjct: 89 ----VAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGS 144
Query: 611 ADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQT 670
D VKIW + G C K+L AH D V + F L + D + WDA + ++T
Sbjct: 145 FDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKT 204
Query: 671 L-EGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTR 706
L + + + + SP+G Y+++++ D +L+LW+ +R
Sbjct: 205 LVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSR 241
Score = 80.9 bits (198), Expect = 5e-15
Identities = 54/186 (29%), Positives = 84/186 (45%), Gaps = 3/186 (1%)
Query: 61 LQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGG 120
L G + V+ + SP+G LA D I I+ G+ T GH I+ + +
Sbjct: 37 LVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSS 96
Query: 121 RLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT 180
RL S S D + +WDV + L LKGH + + F NL+++ D VK W++ T
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKT 156
Query: 181 QHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIA---YLQEIEDPEEPDPKKI 237
C KT+ H V + +++G+ D R+WD A L+ + D + P +
Sbjct: 157 GKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFV 216
Query: 238 KGSSPG 243
K S G
Sbjct: 217 KFSPNG 222
Score = 71.6 bits (174), Expect = 3e-12
Identities = 45/186 (24%), Positives = 83/186 (44%), Gaps = 2/186 (1%)
Query: 36 GRYVAVPACEH-VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSL 94
G ++A + + + IW G+ L G E++ + S D L +D +++++ +
Sbjct: 53 GEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSASDDKTLKLWDV 112
Query: 95 LSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQ 154
SG+ T GH + ++ + SGS D + +W+V L L H D ++
Sbjct: 113 RSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSA 172
Query: 155 ALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEE-KRLITGASDS 213
F +L+V+ D + + WD + C KT+V V S K ++T D+
Sbjct: 173 VHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDN 232
Query: 214 ELRVWD 219
L++WD
Sbjct: 233 TLKLWD 238
Score = 68.9 bits (167), Expect = 2e-11
Identities = 43/196 (21%), Positives = 90/196 (45%), Gaps = 4/196 (2%)
Query: 29 VTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGS 88
V + R V+ + + +WD+R G+ + L+G V C +P + G D +
Sbjct: 89 VAWSSDSSRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDET 148
Query: 89 IRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL-KG 147
++I+ + +G+ T + H ++ + ++ G + SGS D +WD + L L
Sbjct: 149 VKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDD 208
Query: 148 HKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTE---VWGLVLLSEEK 204
++ F ++T+ D +K WD C KT GH+ E ++ ++ K
Sbjct: 209 DNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGK 268
Query: 205 RLITGASDSELRVWDI 220
+++G+ D+ + +W++
Sbjct: 269 WIVSGSEDNLVYIWNL 284
Score = 66.2 bits (160), Expect = 1e-10
Identities = 34/119 (28%), Positives = 60/119 (50%)
Query: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREK 161
T GH A++++K+ G LAS S D II+W + L GH I+ + +
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDS 95
Query: 162 NLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
+ LV++ D +K WD+ + C KT+ GH V+ +I+G+ D +++W++
Sbjct: 96 SRLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEV 154
Score = 48.5 bits (114), Expect = 3e-05
Identities = 31/134 (23%), Positives = 65/134 (48%), Gaps = 6/134 (4%)
Query: 49 IWDLRKGEKI-LILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHK 107
IWD G+ + ++ V+ + SP+G ++ D +++++ G T+ GHK
Sbjct: 193 IWDAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHK 252
Query: 108 AAITTL--KYDQLGGR-LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLL 164
+ + GG+ + SGS+D + +W++ + + +L+GH D + A +NL+
Sbjct: 253 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLI 312
Query: 165 VTSG--KDTMVKWW 176
++ D +K W
Sbjct: 313 ASAALENDKTIKLW 326
Score = 48.1 bits (113), Expect = 4e-05
Identities = 39/180 (21%), Positives = 76/180 (42%), Gaps = 6/180 (3%)
Query: 45 EHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTF- 103
E V IW+++ G+ + L V+ + + G + G DG RI+ SG+ T
Sbjct: 147 ETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLV 206
Query: 104 NGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKD---AITQALFLRE 160
+ ++ +K+ G + + + D + +WD L GHK+ I +
Sbjct: 207 DDDNPPVSFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTG 266
Query: 161 KNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGA--SDSELRVW 218
+V+ +D +V W+L T+ + + GH V E + + A +D +++W
Sbjct: 267 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
>gi|4502477 beta-transducin repeat containing protein isoform 2
[Homo sapiens]
Length = 569
Score = 95.9 bits (237), Expect = 2e-19
Identities = 70/293 (23%), Positives = 138/293 (47%), Gaps = 28/293 (9%)
Query: 426 DNIAVLSAAADS-IKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484
D+ ++S D+ IKIW+++TL+C R +T +R ++ G+ ++++D+
Sbjct: 276 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVN 335
Query: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544
+G +L T+ H A+ + + VT D+S+ WD + + T +R+ V
Sbjct: 336 TGEMLNTLIHHCEAVLHLRFNNGM--MVTCSKDRSIAVWD--MASPTDITLRRVLVGHRA 391
Query: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604
+ + + + K + + D T+K++ T +F +L GHK + C+ +
Sbjct: 392 AVNVVDF--------DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQ--YRDR 441
Query: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
L+ +GS+D +++W ++ G C + L H++ V ++F K + D KIK WD
Sbjct: 442 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLVA 499
Query: 665 FEH---------IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREP 708
++TL H ++ L +VSSSHD ++ +W+ +P
Sbjct: 500 ALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIWDFLNDP 550
Score = 72.8 bits (177), Expect = 1e-12
Identities = 48/159 (30%), Positives = 86/159 (54%), Gaps = 11/159 (6%)
Query: 547 QLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALI 606
+ + V C+ Y +QK+++ L D T+KI+ +TL+ L GH V+C+ +D +I
Sbjct: 265 ETSKGVYCLQYD-DQKIVS-GLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ--YDERVI 320
Query: 607 ATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFE 666
TGS+D V++W ++ G+ +L H ++V++L+F + + T KD I WD
Sbjct: 321 ITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPT 378
Query: 667 HI---QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
I + L GH + V Y+VS+S D+++++W
Sbjct: 379 DITLRRVLVGHRAAV--NVVDFDDKYIVSASGDRTIKVW 415
Score = 72.4 bits (176), Expect = 2e-12
Identities = 57/190 (30%), Positives = 94/190 (49%), Gaps = 16/190 (8%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
IWD E IL G V CL D + G D ++R++ + +GE T H
Sbjct: 291 IWDKNTLECKRILTGHTGSVLCL--QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCE 348
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR---LKGHKDAITQALFLREKNLLV 165
A+ L+++ G + + SKD I VWD+ + + + L GH+ A+ F + +V
Sbjct: 349 AVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIV 404
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRL-ITGASDSELRVWDI---A 221
++ D +K W+ T +T+ GH+ G+ L RL ++G+SD+ +R+WDI A
Sbjct: 405 SASGDRTIKVWNTSTCEFVRTLNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDIECGA 461
Query: 222 YLQEIEDPEE 231
L+ +E EE
Sbjct: 462 CLRVLEGHEE 471
Score = 67.0 bits (162), Expect = 8e-11
Identities = 55/204 (26%), Positives = 96/204 (47%), Gaps = 24/204 (11%)
Query: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQ-KRLSVKQTRTLQLDEDVLCVSYSPNQK 562
L D + V+G D ++K W D+N+ + KR+ T + VLC+ Y +++
Sbjct: 273 LQYDDQKIVSGLRDNTIKIW------DKNTLECKRILTGHTGS------VLCLQY--DER 318
Query: 563 LLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDF 622
++ D TV+++ V+T + +L H V + + + ++ T S DR++ +W +
Sbjct: 319 VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMAS 376
Query: 623 G---DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIW 679
+ L H +V + F K +A D IK W+ E ++TL GH + I
Sbjct: 377 PTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA 434
Query: 680 CLAVSPSGDYVVSSSHDKSLRLWE 703
CL VVS S D ++RLW+
Sbjct: 435 CLQYRDR--LVVSGSSDNTIRLWD 456
Score = 63.2 bits (152), Expect = 1e-09
Identities = 49/178 (27%), Positives = 89/178 (50%), Gaps = 13/178 (7%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-- 104
V +WD+ GE + L + V L + +G+ + +D SI ++ + S ++T
Sbjct: 329 VRVWDVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTCS-KDRSIAVWDMASPT-DITLRRV 385
Query: 105 --GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
GH+AA+ + +D + S S D I VW+ + L GHK I L R++
Sbjct: 386 LVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA-CLQYRDR- 441
Query: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
L+V+ D ++ WD++ C + + GH V + + KR+++GA D +++VWD+
Sbjct: 442 LVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDL 497
Score = 59.3 bits (142), Expect = 2e-08
Identities = 40/151 (26%), Positives = 72/151 (47%), Gaps = 9/151 (5%)
Query: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
C D + G D +I+I+ + E GH ++ L+YD+ + +GS D+ +
Sbjct: 272 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE--RVIITGSSDSTV 329
Query: 132 IVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF---KTMV 188
VWDV L L H +A+ F ++VT KD + WD+ + + +V
Sbjct: 330 RVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLV 387
Query: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
GHR V V+ ++K +++ + D ++VW+
Sbjct: 388 GHRAAV--NVVDFDDKYIVSASGDRTIKVWN 416
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/57 (40%), Positives = 36/57 (63%), Gaps = 2/57 (3%)
Query: 164 LVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
+V+ +D +K WD +T C + + GH V L L +E+ +ITG+SDS +RVWD+
Sbjct: 280 IVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDV 334
Score = 39.3 bits (90), Expect = 0.017
Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+W+ E + L G K+ + CL D L ++ G D +IR++ + G GH+
Sbjct: 414 VWNTSTCEFVRTLNGHKRGIACL-QYRDRLVVS-GSSDNTIRLWDIECGACLRVLEGHEE 471
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVI 137
+ +++D R+ SG+ D I VWD++
Sbjct: 472 LVRCIRFDNK--RIVSGAYDGKIKVWDLV 498
>gi|16117783 beta-transducin repeat containing protein isoform 1
[Homo sapiens]
Length = 605
Score = 95.9 bits (237), Expect = 2e-19
Identities = 70/293 (23%), Positives = 138/293 (47%), Gaps = 28/293 (9%)
Query: 426 DNIAVLSAAADS-IKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLA 484
D+ ++S D+ IKIW+++TL+C R +T +R ++ G+ ++++D+
Sbjct: 312 DDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDERVIITGSSDSTVRVWDVN 371
Query: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544
+G +L T+ H A+ + + VT D+S+ WD + + T +R+ V
Sbjct: 372 TGEMLNTLIHHCEAVLHLRFNNGM--MVTCSKDRSIAVWD--MASPTDITLRRVLVGHRA 427
Query: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604
+ + + + K + + D T+K++ T +F +L GHK + C+ +
Sbjct: 428 AVNVVDF--------DDKYIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIACLQ--YRDR 477
Query: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
L+ +GS+D +++W ++ G C + L H++ V ++F K + D KIK WD
Sbjct: 478 LVVSGSSDNTIRLWDIECGACLRVLEGHEELVRCIRFDNKR--IVSGAYDGKIKVWDLVA 535
Query: 665 FEH---------IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREP 708
++TL H ++ L +VSSSHD ++ +W+ +P
Sbjct: 536 ALDPRAPAGTLCLRTLVEHSGRVFRLQFDEF--QIVSSSHDDTILIWDFLNDP 586
Score = 72.8 bits (177), Expect = 1e-12
Identities = 48/159 (30%), Positives = 86/159 (54%), Gaps = 11/159 (6%)
Query: 547 QLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALI 606
+ + V C+ Y +QK+++ L D T+KI+ +TL+ L GH V+C+ +D +I
Sbjct: 301 ETSKGVYCLQYD-DQKIVS-GLRDNTIKIWDKNTLECKRILTGHTGSVLCLQ--YDERVI 356
Query: 607 ATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFE 666
TGS+D V++W ++ G+ +L H ++V++L+F + + T KD I WD
Sbjct: 357 ITGSSDSTVRVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPT 414
Query: 667 HI---QTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
I + L GH + V Y+VS+S D+++++W
Sbjct: 415 DITLRRVLVGHRAAV--NVVDFDDKYIVSASGDRTIKVW 451
Score = 72.4 bits (176), Expect = 2e-12
Identities = 57/190 (30%), Positives = 94/190 (49%), Gaps = 16/190 (8%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
IWD E IL G V CL D + G D ++R++ + +GE T H
Sbjct: 327 IWDKNTLECKRILTGHTGSVLCL--QYDERVIITGSSDSTVRVWDVNTGEMLNTLIHHCE 384
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR---LKGHKDAITQALFLREKNLLV 165
A+ L+++ G + + SKD I VWD+ + + + L GH+ A+ F + +V
Sbjct: 385 AVLHLRFN--NGMMVTCSKDRSIAVWDMASPTDITLRRVLVGHRAAVNVVDF--DDKYIV 440
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRL-ITGASDSELRVWDI---A 221
++ D +K W+ T +T+ GH+ G+ L RL ++G+SD+ +R+WDI A
Sbjct: 441 SASGDRTIKVWNTSTCEFVRTLNGHKR---GIACLQYRDRLVVSGSSDNTIRLWDIECGA 497
Query: 222 YLQEIEDPEE 231
L+ +E EE
Sbjct: 498 CLRVLEGHEE 507
Score = 67.0 bits (162), Expect = 8e-11
Identities = 55/204 (26%), Positives = 96/204 (47%), Gaps = 24/204 (11%)
Query: 504 LSPDQRGFVTGGADKSVKFWDFELVKDENSTQ-KRLSVKQTRTLQLDEDVLCVSYSPNQK 562
L D + V+G D ++K W D+N+ + KR+ T + VLC+ Y +++
Sbjct: 309 LQYDDQKIVSGLRDNTIKIW------DKNTLECKRILTGHTGS------VLCLQY--DER 354
Query: 563 LLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDF 622
++ D TV+++ V+T + +L H V + + + ++ T S DR++ +W +
Sbjct: 355 VIITGSSDSTVRVWDVNTGEMLNTLIHHCEAV--LHLRFNNGMMVTCSKDRSIAVWDMAS 412
Query: 623 G---DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIW 679
+ L H +V + F K +A D IK W+ E ++TL GH + I
Sbjct: 413 PTDITLRRVLVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA 470
Query: 680 CLAVSPSGDYVVSSSHDKSLRLWE 703
CL VVS S D ++RLW+
Sbjct: 471 CLQYRDR--LVVSGSSDNTIRLWD 492
Score = 63.2 bits (152), Expect = 1e-09
Identities = 49/178 (27%), Positives = 89/178 (50%), Gaps = 13/178 (7%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-- 104
V +WD+ GE + L + V L + +G+ + +D SI ++ + S ++T
Sbjct: 365 VRVWDVNTGEMLNTLIHHCEAVLHLRFN-NGMMVTCS-KDRSIAVWDMASPT-DITLRRV 421
Query: 105 --GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
GH+AA+ + +D + S S D I VW+ + L GHK I L R++
Sbjct: 422 LVGHRAAVNVVDFDDK--YIVSASGDRTIKVWNTSTCEFVRTLNGHKRGIA-CLQYRDR- 477
Query: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
L+V+ D ++ WD++ C + + GH V + + KR+++GA D +++VWD+
Sbjct: 478 LVVSGSSDNTIRLWDIECGACLRVLEGHEELV--RCIRFDNKRIVSGAYDGKIKVWDL 533
Score = 59.3 bits (142), Expect = 2e-08
Identities = 40/151 (26%), Positives = 72/151 (47%), Gaps = 9/151 (5%)
Query: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
C D + G D +I+I+ + E GH ++ L+YD+ + +GS D+ +
Sbjct: 308 CLQYDDQKIVSGLRDNTIKIWDKNTLECKRILTGHTGSVLCLQYDE--RVIITGSSDSTV 365
Query: 132 IVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF---KTMV 188
VWDV L L H +A+ F ++VT KD + WD+ + + +V
Sbjct: 366 RVWDVNTGEMLNTLIHHCEAVLHLRF--NNGMMVTCSKDRSIAVWDMASPTDITLRRVLV 423
Query: 189 GHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
GHR V V+ ++K +++ + D ++VW+
Sbjct: 424 GHRAAV--NVVDFDDKYIVSASGDRTIKVWN 452
Score = 48.9 bits (115), Expect = 2e-05
Identities = 23/57 (40%), Positives = 36/57 (63%), Gaps = 2/57 (3%)
Query: 164 LVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
+V+ +D +K WD +T C + + GH V L L +E+ +ITG+SDS +RVWD+
Sbjct: 316 IVSGLRDNTIKIWDKNTLECKRILTGHTGSV--LCLQYDERVIITGSSDSTVRVWDV 370
Score = 39.3 bits (90), Expect = 0.017
Identities = 25/89 (28%), Positives = 45/89 (50%), Gaps = 4/89 (4%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+W+ E + L G K+ + CL D L ++ G D +IR++ + G GH+
Sbjct: 450 VWNTSTCEFVRTLNGHKRGIACL-QYRDRLVVS-GSSDNTIRLWDIECGACLRVLEGHEE 507
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVI 137
+ +++D R+ SG+ D I VWD++
Sbjct: 508 LVRCIRFDNK--RIVSGAYDGKIKVWDLV 534
>gi|32483359 apoptotic peptidase activating factor 1 isoform c [Homo
sapiens]
Length = 1248
Score = 95.9 bits (237), Expect = 2e-19
Identities = 136/672 (20%), Positives = 250/672 (37%), Gaps = 124/672 (18%)
Query: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
C S DG +A D ++++F +GE + H+ + + +A+ S D +
Sbjct: 622 CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKV 681
Query: 132 IVWDVINESGLYRLKGHKDAITQALFLREKN--LLVTSGKDTMVKWWDLDTQHCFKTMVG 189
+W+ + ++ H + + F + LL T D +K WDL+ + C TM G
Sbjct: 682 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 741
Query: 190 HRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQE------------IEDPEEPDPKKI 237
H V ++K L + ++D L++WD E +EDP+E +
Sbjct: 742 HTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIV 801
Query: 238 K---GSSPGIQDTLEAEDGAF----------------------ETDEAPEDRILSCRKAG 272
K S+ G + + A++ F D +P++ + +
Sbjct: 802 KCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ 861
Query: 273 SIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQK-KMDKKMKKARKKAKL 331
+ + D G + HG + L+ + Q ++ + K + A +
Sbjct: 862 YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM 921
Query: 332 HSSKGEEEDPEVNVEMSLQDEIQRVTNIK---------TSAKIKSFDLIHSPHGELKAVF 382
+ + E V + D I+R+ I T A++ L SPH + A F
Sbjct: 922 LKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIA-F 978
Query: 383 LLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIW 441
+N +E+ L + SR H+ V + F++D ++S++ D+ I++W
Sbjct: 979 GDENGAIEILEL-----VNNRIFQSRFQ---HKKTVWHIQFTADEKTLISSSDDAEIQVW 1030
Query: 442 NRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWS 501
N +CI + + F + + +++ + G ++++++ +GN + H G + S
Sbjct: 1031 NWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS 1090
Query: 502 MSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQ 561
+S D F + ADK+ K W F+L+ L L E
Sbjct: 1091 CDISHDATKFSSTSADKTAKIWSFDLL-----------------LPLHE----------- 1122
Query: 562 KLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLD 621
L GH V C S D L+ATG + ++IW +
Sbjct: 1123 -------------------------LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1157
Query: 622 FGD--------CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEG 673
G+ + H V L F P + +AG IK W+ E QT
Sbjct: 1158 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYT 1215
Query: 674 HHQEIWCLAVSP 685
+ + + VSP
Sbjct: 1216 NGTNLKKIHVSP 1227
Score = 85.9 bits (211), Expect = 2e-16
Identities = 137/657 (20%), Positives = 235/657 (35%), Gaps = 144/657 (21%)
Query: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
H A+ + + G R+AS D + V+ L +K H+D + F + +
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEV--WGLVLLSEEKRLITGASDSELRVWDIAYL 223
T D VK W+ T T H +V S L TG+SD L++WD+
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL--- 730
Query: 224 QEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVV 283
+ K+ + + G +++ +P+D++L+ A
Sbjct: 731 ---------NQKECRNTMFGHTNSVN------HCRFSPDDKLLASCSA------------ 763
Query: 284 NLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEV 343
D L+L+ S E K K + + +ED EV
Sbjct: 764 ----------------DGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEV 799
Query: 344 NVEMSLQDEIQRVTNIKTSAKIKSFDL--------IHSPHGEL-----------KAVFLL 384
V+ + KI FD+ IH+ H AV L
Sbjct: 800 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 859
Query: 385 QNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNR 443
VEL++ + R+ GH S V + FS D + L+++ D +I++W
Sbjct: 860 SQYCVELWNTDS--------RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 911
Query: 444 S--------------------------------TLQCI--RTMTCEY-----ALCSFFVP 464
LQ I RT +Y C P
Sbjct: 912 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 971
Query: 465 GDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
+ + G + G +++ +L + + ++ H +W + + D++ ++ D ++ W+
Sbjct: 972 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1031
Query: 525 FELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFF 584
++L K + +VK R L+ N +LL+ S D TVK++ + T
Sbjct: 1032 WQLDKCIFLRGHQETVKDFRLLK------------NSRLLSWS-FDGTVKVWNIITGNKE 1078
Query: 585 LSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPK 644
H+ V+ DISHD ++ SAD+ KIW D L H+ V F
Sbjct: 1079 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1138
Query: 645 SHLFFTAGKDHKIKQWDADKFEHIQ-----TLEG---HHQEIWCLAVSPSGDYVVSS 693
S L T + +I+ W+ E + + EG H + L SP G ++S+
Sbjct: 1139 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1195
Score = 85.1 bits (209), Expect = 3e-16
Identities = 77/320 (24%), Positives = 138/320 (43%), Gaps = 39/320 (12%)
Query: 407 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTC--EYALCSFFV 463
SR+ + H V FS D + S AD +++++ T + + + + LC F
Sbjct: 607 SRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFS 666
Query: 464 PGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFV--TGGADKSVK 521
DR + + K+++++ +G L+ T D H + + + TG +D +K
Sbjct: 667 TDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 726
Query: 522 FWDFELVKDENSTQKRL-SVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIF---- 576
WD + N+ SV R +SP+ KLLA D T+K++
Sbjct: 727 LWDLNQKECRNTMFGHTNSVNHCR------------FSPDDKLLASCSADGTLKLWDATS 774
Query: 577 -----YVDTLKFFLSLYGHK----LPVICMDISHDGALIATGSADR----NVKIWGLDFG 623
++ +FFL+L + + V C S DGA I + ++ ++ GL G
Sbjct: 775 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGL-LG 833
Query: 624 DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 683
+ H H ++ Y F P++HL A + ++ W+ D + GH + +
Sbjct: 834 EIHTG---HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMF 890
Query: 684 SPSGDYVVSSSHDKSLRLWE 703
SP G ++SS D+++RLWE
Sbjct: 891 SPDGSSFLTSSDDQTIRLWE 910
Score = 72.8 bits (177), Expect = 1e-12
Identities = 46/151 (30%), Positives = 71/151 (47%), Gaps = 2/151 (1%)
Query: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVK 616
+S + + +A D T+++F +T + L + H+ V+C S D IAT S D+ VK
Sbjct: 623 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 682
Query: 617 IWGLDFGDCHKSLFAHDDSVMYLQFVPKSH--LFFTAGKDHKIKQWDADKFEHIQTLEGH 674
IW G+ + H + V F SH L T D +K WD ++ E T+ GH
Sbjct: 683 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 742
Query: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705
+ SP + S S D +L+LW+ T
Sbjct: 743 TNSVNHCRFSPDDKLLASCSADGTLKLWDAT 773
Score = 64.7 bits (156), Expect = 4e-10
Identities = 117/612 (19%), Positives = 229/612 (37%), Gaps = 67/612 (10%)
Query: 128 DTDIIVWDVINESGLYRL-----KGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQH 182
D ++ + IN+ + L + H DA+ A F + + + G D ++ + +T
Sbjct: 589 DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 648
Query: 183 CFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI----EDPEEPDPKKIK 238
+ H EV ++++ + T + D ++++W+ + + E E+ +
Sbjct: 649 KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT 708
Query: 239 GSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHG 298
SS + + D + + L+ ++ + M + V + ++LA
Sbjct: 709 NSSHHLLLATGSSDCFLKLWD------LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCS 762
Query: 299 TDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTN 358
D L+L+ S E K K + + +ED EV V+
Sbjct: 763 ADGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 814
Query: 359 IKTSAKIKSFDL--------IHSPHGEL-----------KAVFLLQNNLVELYSLNPSLP 399
+ KI FD+ IH+ H AV L VEL++ +
Sbjct: 815 VAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDS--- 871
Query: 400 TPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYAL 458
R+ GH S V + FS D + L+++ D +I++W + + + +
Sbjct: 872 -----RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEV 926
Query: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518
F + V+ +LQL + +G + +A LSP + G +
Sbjct: 927 DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCC---CLSPHLQYIAFGDENG 983
Query: 519 SVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV 578
+++ ELV + Q R K+T V + ++ ++K L S D ++++
Sbjct: 984 AIEI--LELVNNR-IFQSRFQHKKT--------VWHIQFTADEKTLISSSDDAEIQVWNW 1032
Query: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
K L GH+ V + + L++ S D VK+W + G+ K H +V+
Sbjct: 1033 QLDKCIF-LRGHQETVKDFRLLKNSRLLSW-SFDGTVKVWNIITGNKEKDFVCHQGTVLS 1090
Query: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698
+ F + D K W D + L GH+ + C A S + + +
Sbjct: 1091 CDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGE 1150
Query: 699 LRLWERTREPLI 710
+R+W + L+
Sbjct: 1151 IRIWNVSNGELL 1162
Score = 60.5 bits (145), Expect = 7e-09
Identities = 47/190 (24%), Positives = 87/190 (45%), Gaps = 2/190 (1%)
Query: 39 VAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGE 98
V V A +H+ L G I + +V+C C SP ++A G E+G+I I L++
Sbjct: 935 VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 994
Query: 99 GNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFL 158
+ HK + +++ L S S D +I VW+ + ++ L+GH++ + L
Sbjct: 995 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL 1053
Query: 159 REKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
+ LL S D VK W++ T + K V H+ V + + + + ++D ++W
Sbjct: 1054 KNSRLLSWS-FDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1112
Query: 219 DIAYLQEIED 228
L + +
Sbjct: 1113 SFDLLLPLHE 1122
Score = 54.7 bits (130), Expect = 4e-07
Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 2/131 (1%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
++ GEK+L ++ + EV C S D +A D ++I++ ++GE T++ H
Sbjct: 641 VFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 700
Query: 109 AITTLKYDQLGGR--LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+ + LA+GS D + +WD+ + + GH +++ F + LL +
Sbjct: 701 QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLAS 760
Query: 167 SGKDTMVKWWD 177
D +K WD
Sbjct: 761 CSADGTLKLWD 771
Score = 46.2 bits (108), Expect = 1e-04
Identities = 96/512 (18%), Positives = 187/512 (36%), Gaps = 71/512 (13%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN---- 104
+WDL + E + G V SPD LA DG+++++ S + N
Sbjct: 727 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 786
Query: 105 ---------GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLK-GHKDAITQ 154
+ + + G R+ +K+ I ++D+ L + GH I
Sbjct: 787 FLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQY 845
Query: 155 ALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSE 214
F + +L V + V+ W+ D++ GH + V G++ + +T + D
Sbjct: 846 CDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 905
Query: 215 LRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRI----LSCRK 270
+R+W+ K K S+ ++ ++ E D I L +
Sbjct: 906 IRLWE-------------TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGR 952
Query: 271 AGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAK 330
G I +V + + +A + +E+ +++ + Q + KK
Sbjct: 953 TGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ------HKKTV 1006
Query: 331 LHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVE 390
H +E ++ S D +V N + I + +K LL+N+ +
Sbjct: 1007 WHIQFTADEKTLIS---SSDDAEIQVWNWQLDKCI----FLRGHQETVKDFRLLKNSRLL 1059
Query: 391 LYSLNPSLPTPQPVRTSRITIGGHRSD-------VRTLSFSSDNIAVLSAAAD-SIKIWN 442
+S + + V+ I G D V + S D S +AD + KIW+
Sbjct: 1060 SWSFDGT------VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1113
Query: 443 RSTLQCIRTMTCEYAL--CSFFVPGDRQVVIGTKTGKLQLYDLASGNLL--------ETI 492
L + + CS F + G G+++++++++G LL E
Sbjct: 1114 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1173
Query: 493 DAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
H G + + SPD + ++ G +K+W+
Sbjct: 1174 ATHGGWVTDLCFSPDGKMLISAGG--YIKWWN 1203
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/88 (21%), Positives = 39/88 (44%)
Query: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVV 691
H D+V + F + G D ++ + A+ E + ++ H E+ C A S ++
Sbjct: 614 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 673
Query: 692 SSSHDKSLRLWERTREPLILEEEREMER 719
+ S DK +++W L+ + E+
Sbjct: 674 TCSVDKKVKIWNSMTGELVHTYDEHSEQ 701
Score = 39.7 bits (91), Expect = 0.013
Identities = 26/132 (19%), Positives = 60/132 (45%), Gaps = 4/132 (3%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V+ W L +K + L+G ++ V + L+ + DG+++++++++G F H
Sbjct: 1029 VWNWQL---DKCIFLRGHQETVKDFRLLKNSRLLSWSF-DGTVKVWNIITGNKEKDFVCH 1084
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+ + + + +S S D +W L+ L+GH + + F + LL T
Sbjct: 1085 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1144
Query: 167 SGKDTMVKWWDL 178
+ ++ W++
Sbjct: 1145 GDDNGEIRIWNV 1156
Score = 31.2 bits (69), Expect = 4.8
Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 10/112 (8%)
Query: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLY--------RLKGHKDAITQAL 156
GH + + LA+G + +I +W+V N L+ H +T
Sbjct: 1125 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1184
Query: 157 FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLIT 208
F + +L+++G +KWW++ T +T + T + + + + K +T
Sbjct: 1185 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1234
>gi|7108333 apoptotic peptidase activating factor 1 isoform a [Homo
sapiens]
Length = 1237
Score = 95.9 bits (237), Expect = 2e-19
Identities = 136/672 (20%), Positives = 250/672 (37%), Gaps = 124/672 (18%)
Query: 72 CPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDI 131
C S DG +A D ++++F +GE + H+ + + +A+ S D +
Sbjct: 611 CFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKV 670
Query: 132 IVWDVINESGLYRLKGHKDAITQALFLREKN--LLVTSGKDTMVKWWDLDTQHCFKTMVG 189
+W+ + ++ H + + F + LL T D +K WDL+ + C TM G
Sbjct: 671 KIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFG 730
Query: 190 HRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQE------------IEDPEEPDPKKI 237
H V ++K L + ++D L++WD E +EDP+E +
Sbjct: 731 HTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIV 790
Query: 238 K---GSSPGIQDTLEAEDGAF----------------------ETDEAPEDRILSCRKAG 272
K S+ G + + A++ F D +P++ + +
Sbjct: 791 KCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQ 850
Query: 273 SIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQK-KMDKKMKKARKKAKL 331
+ + D G + HG + L+ + Q ++ + K + A +
Sbjct: 851 YCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVM 910
Query: 332 HSSKGEEEDPEVNVEMSLQDEIQRVTNIK---------TSAKIKSFDLIHSPHGELKAVF 382
+ + E V + D I+R+ I T A++ L SPH + A F
Sbjct: 911 LKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCL--SPHLQYIA-F 967
Query: 383 LLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIW 441
+N +E+ L + SR H+ V + F++D ++S++ D+ I++W
Sbjct: 968 GDENGAIEILEL-----VNNRIFQSRFQ---HKKTVWHIQFTADEKTLISSSDDAEIQVW 1019
Query: 442 NRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWS 501
N +CI + + F + + +++ + G ++++++ +GN + H G + S
Sbjct: 1020 NWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLS 1079
Query: 502 MSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQ 561
+S D F + ADK+ K W F+L+ L L E
Sbjct: 1080 CDISHDATKFSSTSADKTAKIWSFDLL-----------------LPLHE----------- 1111
Query: 562 KLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLD 621
L GH V C S D L+ATG + ++IW +
Sbjct: 1112 -------------------------LRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVS 1146
Query: 622 FGD--------CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEG 673
G+ + H V L F P + +AG IK W+ E QT
Sbjct: 1147 NGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAG--GYIKWWNVVTGESSQTFYT 1204
Query: 674 HHQEIWCLAVSP 685
+ + + VSP
Sbjct: 1205 NGTNLKKIHVSP 1216
Score = 85.9 bits (211), Expect = 2e-16
Identities = 137/657 (20%), Positives = 235/657 (35%), Gaps = 144/657 (21%)
Query: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
H A+ + + G R+AS D + V+ L +K H+D + F + +
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEV--WGLVLLSEEKRLITGASDSELRVWDIAYL 223
T D VK W+ T T H +V S L TG+SD L++WD+
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDL--- 719
Query: 224 QEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVV 283
+ K+ + + G +++ +P+D++L+ A
Sbjct: 720 ---------NQKECRNTMFGHTNSVN------HCRFSPDDKLLASCSA------------ 752
Query: 284 NLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEV 343
D L+L+ S E K K + + +ED EV
Sbjct: 753 ----------------DGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEV 788
Query: 344 NVEMSLQDEIQRVTNIKTSAKIKSFDL--------IHSPHGEL-----------KAVFLL 384
V+ + KI FD+ IH+ H AV L
Sbjct: 789 IVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVAL 848
Query: 385 QNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNR 443
VEL++ + R+ GH S V + FS D + L+++ D +I++W
Sbjct: 849 SQYCVELWNTDS--------RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWET 900
Query: 444 S--------------------------------TLQCI--RTMTCEY-----ALCSFFVP 464
LQ I RT +Y C P
Sbjct: 901 KKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSP 960
Query: 465 GDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
+ + G + G +++ +L + + ++ H +W + + D++ ++ D ++ W+
Sbjct: 961 HLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWN 1020
Query: 525 FELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFF 584
++L K + +VK R L+ N +LL+ S D TVK++ + T
Sbjct: 1021 WQLDKCIFLRGHQETVKDFRLLK------------NSRLLSWS-FDGTVKVWNIITGNKE 1067
Query: 585 LSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPK 644
H+ V+ DISHD ++ SAD+ KIW D L H+ V F
Sbjct: 1068 KDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVD 1127
Query: 645 SHLFFTAGKDHKIKQWDADKFEHIQ-----TLEG---HHQEIWCLAVSPSGDYVVSS 693
S L T + +I+ W+ E + + EG H + L SP G ++S+
Sbjct: 1128 STLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISA 1184
Score = 85.1 bits (209), Expect = 3e-16
Identities = 77/320 (24%), Positives = 138/320 (43%), Gaps = 39/320 (12%)
Query: 407 SRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTC--EYALCSFFV 463
SR+ + H V FS D + S AD +++++ T + + + + LC F
Sbjct: 596 SRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFS 655
Query: 464 PGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFV--TGGADKSVK 521
DR + + K+++++ +G L+ T D H + + + TG +D +K
Sbjct: 656 TDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLK 715
Query: 522 FWDFELVKDENSTQKRL-SVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIF---- 576
WD + N+ SV R +SP+ KLLA D T+K++
Sbjct: 716 LWDLNQKECRNTMFGHTNSVNHCR------------FSPDDKLLASCSADGTLKLWDATS 763
Query: 577 -----YVDTLKFFLSLYGHK----LPVICMDISHDGALIATGSADR----NVKIWGLDFG 623
++ +FFL+L + + V C S DGA I + ++ ++ GL G
Sbjct: 764 ANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGL-LG 822
Query: 624 DCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 683
+ H H ++ Y F P++HL A + ++ W+ D + GH + +
Sbjct: 823 EIHTG---HHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMF 879
Query: 684 SPSGDYVVSSSHDKSLRLWE 703
SP G ++SS D+++RLWE
Sbjct: 880 SPDGSSFLTSSDDQTIRLWE 899
Score = 72.8 bits (177), Expect = 1e-12
Identities = 46/151 (30%), Positives = 71/151 (47%), Gaps = 2/151 (1%)
Query: 557 YSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVK 616
+S + + +A D T+++F +T + L + H+ V+C S D IAT S D+ VK
Sbjct: 612 FSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVK 671
Query: 617 IWGLDFGDCHKSLFAHDDSVMYLQFVPKSH--LFFTAGKDHKIKQWDADKFEHIQTLEGH 674
IW G+ + H + V F SH L T D +K WD ++ E T+ GH
Sbjct: 672 IWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGH 731
Query: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705
+ SP + S S D +L+LW+ T
Sbjct: 732 TNSVNHCRFSPDDKLLASCSADGTLKLWDAT 762
Score = 64.7 bits (156), Expect = 4e-10
Identities = 117/612 (19%), Positives = 229/612 (37%), Gaps = 67/612 (10%)
Query: 128 DTDIIVWDVINESGLYRL-----KGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQH 182
D ++ + IN+ + L + H DA+ A F + + + G D ++ + +T
Sbjct: 578 DNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGE 637
Query: 183 CFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI----EDPEEPDPKKIK 238
+ H EV ++++ + T + D ++++W+ + + E E+ +
Sbjct: 638 KLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFT 697
Query: 239 GSSPGIQDTLEAEDGAFETDEAPEDRILSCRKAGSIMREGRDRVVNLAVDKTGRILACHG 298
SS + + D + + L+ ++ + M + V + ++LA
Sbjct: 698 NSSHHLLLATGSSDCFLKLWD------LNQKECRNTMFGHTNSVNHCRFSPDDKLLASCS 751
Query: 299 TDSVLELFCILSKKEIQKKMDKKMKKARKKAKLHSSKGEEEDPEVNVEMSLQDEIQRVTN 358
D L+L+ S E K K + + +ED EV V+
Sbjct: 752 ADGTLKLWDATSANE--------RKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIM 803
Query: 359 IKTSAKIKSFDL--------IHSPHGEL-----------KAVFLLQNNLVELYSLNPSLP 399
+ KI FD+ IH+ H AV L VEL++ +
Sbjct: 804 VAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDS--- 860
Query: 400 TPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYAL 458
R+ GH S V + FS D + L+++ D +I++W + + + +
Sbjct: 861 -----RSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEV 915
Query: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518
F + V+ +LQL + +G + +A LSP + G +
Sbjct: 916 DVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCC---CLSPHLQYIAFGDENG 972
Query: 519 SVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV 578
+++ ELV + Q R K+T V + ++ ++K L S D ++++
Sbjct: 973 AIEI--LELVNNR-IFQSRFQHKKT--------VWHIQFTADEKTLISSSDDAEIQVWNW 1021
Query: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
K L GH+ V + + L++ S D VK+W + G+ K H +V+
Sbjct: 1022 QLDKCIF-LRGHQETVKDFRLLKNSRLLSW-SFDGTVKVWNIITGNKEKDFVCHQGTVLS 1079
Query: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698
+ F + D K W D + L GH+ + C A S + + +
Sbjct: 1080 CDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGE 1139
Query: 699 LRLWERTREPLI 710
+R+W + L+
Sbjct: 1140 IRIWNVSNGELL 1151
Score = 60.5 bits (145), Expect = 7e-09
Identities = 47/190 (24%), Positives = 87/190 (45%), Gaps = 2/190 (1%)
Query: 39 VAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGE 98
V V A +H+ L G I + +V+C C SP ++A G E+G+I I L++
Sbjct: 924 VMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNR 983
Query: 99 GNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFL 158
+ HK + +++ L S S D +I VW+ + ++ L+GH++ + L
Sbjct: 984 IFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIF-LRGHQETVKDFRLL 1042
Query: 159 REKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
+ LL S D VK W++ T + K V H+ V + + + + ++D ++W
Sbjct: 1043 KNSRLLSWS-FDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIW 1101
Query: 219 DIAYLQEIED 228
L + +
Sbjct: 1102 SFDLLLPLHE 1111
Score = 54.7 bits (130), Expect = 4e-07
Identities = 32/131 (24%), Positives = 61/131 (46%), Gaps = 2/131 (1%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
++ GEK+L ++ + EV C S D +A D ++I++ ++GE T++ H
Sbjct: 630 VFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSE 689
Query: 109 AITTLKYDQLGGR--LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+ + LA+GS D + +WD+ + + GH +++ F + LL +
Sbjct: 690 QVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLAS 749
Query: 167 SGKDTMVKWWD 177
D +K WD
Sbjct: 750 CSADGTLKLWD 760
Score = 46.2 bits (108), Expect = 1e-04
Identities = 96/512 (18%), Positives = 187/512 (36%), Gaps = 71/512 (13%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN---- 104
+WDL + E + G V SPD LA DG+++++ S + N
Sbjct: 716 LWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQF 775
Query: 105 ---------GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLK-GHKDAITQ 154
+ + + G R+ +K+ I ++D+ L + GH I
Sbjct: 776 FLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNK-IFLFDIHTSGLLGEIHTGHHSTIQY 834
Query: 155 ALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSE 214
F + +L V + V+ W+ D++ GH + V G++ + +T + D
Sbjct: 835 CDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQT 894
Query: 215 LRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAEDGAFETDEAPEDRI----LSCRK 270
+R+W+ K K S+ ++ ++ E D I L +
Sbjct: 895 IRLWE-------------TKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGR 941
Query: 271 AGSIMREGRDRVVNLAVDKTGRILACHGTDSVLELFCILSKKEIQKKMDKKMKKARKKAK 330
G I +V + + +A + +E+ +++ + Q + KK
Sbjct: 942 TGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQ------HKKTV 995
Query: 331 LHSSKGEEEDPEVNVEMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVE 390
H +E ++ S D +V N + I + +K LL+N+ +
Sbjct: 996 WHIQFTADEKTLIS---SSDDAEIQVWNWQLDKCI----FLRGHQETVKDFRLLKNSRLL 1048
Query: 391 LYSLNPSLPTPQPVRTSRITIGGHRSD-------VRTLSFSSDNIAVLSAAAD-SIKIWN 442
+S + + V+ I G D V + S D S +AD + KIW+
Sbjct: 1049 SWSFDGT------VKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWS 1102
Query: 443 RSTLQCIRTMTCEYAL--CSFFVPGDRQVVIGTKTGKLQLYDLASGNLL--------ETI 492
L + + CS F + G G+++++++++G LL E
Sbjct: 1103 FDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGA 1162
Query: 493 DAHDGALWSMSLSPDQRGFVTGGADKSVKFWD 524
H G + + SPD + ++ G +K+W+
Sbjct: 1163 ATHGGWVTDLCFSPDGKMLISAGG--YIKWWN 1192
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/88 (21%), Positives = 39/88 (44%)
Query: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVV 691
H D+V + F + G D ++ + A+ E + ++ H E+ C A S ++
Sbjct: 603 HTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIA 662
Query: 692 SSSHDKSLRLWERTREPLILEEEREMER 719
+ S DK +++W L+ + E+
Sbjct: 663 TCSVDKKVKIWNSMTGELVHTYDEHSEQ 690
Score = 39.7 bits (91), Expect = 0.013
Identities = 26/132 (19%), Positives = 60/132 (45%), Gaps = 4/132 (3%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V+ W L +K + L+G ++ V + L+ + DG+++++++++G F H
Sbjct: 1018 VWNWQL---DKCIFLRGHQETVKDFRLLKNSRLLSWSF-DGTVKVWNIITGNKEKDFVCH 1073
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+ + + + +S S D +W L+ L+GH + + F + LL T
Sbjct: 1074 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLAT 1133
Query: 167 SGKDTMVKWWDL 178
+ ++ W++
Sbjct: 1134 GDDNGEIRIWNV 1145
Score = 31.2 bits (69), Expect = 4.8
Identities = 23/112 (20%), Positives = 47/112 (41%), Gaps = 10/112 (8%)
Query: 105 GHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLY--------RLKGHKDAITQAL 156
GH + + LA+G + +I +W+V N L+ H +T
Sbjct: 1114 GHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLC 1173
Query: 157 FLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLIT 208
F + +L+++G +KWW++ T +T + T + + + + K +T
Sbjct: 1174 FSPDGKMLISAG--GYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVT 1223
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 93.6 bits (231), Expect = 8e-19
Identities = 69/239 (28%), Positives = 109/239 (45%), Gaps = 9/239 (3%)
Query: 19 IGSQKGNIVFVTLRGEKGRYVAVPACE-HVFIWDLRKGEKILILQGLKQEVTCLCPSPDG 77
I + N+ + L GR +A + V +W + K I+ L G V + +
Sbjct: 16 IVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPE 75
Query: 78 LHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVI 137
+ G + GSIR++ L + + T GHKA I +L + G +ASGS+DT+I +WD+
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIR 135
Query: 138 NESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGL 197
+ ++R +GH A+ F + L ++ D VK WDL GH V +
Sbjct: 136 RKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVV 195
Query: 198 VLLSEEKRLITGASDSELRVWDIAYLQEIEDPE-EPDPKKIKGSSP-------GIQDTL 248
E L +G+SD +R WD+ Q + E EP P + +P G QD+L
Sbjct: 196 EFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQDSL 254
Score = 85.5 bits (210), Expect = 2e-16
Identities = 59/243 (24%), Positives = 103/243 (42%), Gaps = 16/243 (6%)
Query: 467 RQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFE 526
R + G ++ L+ + N + ++ H + S+ L+ + V G S++ WD E
Sbjct: 34 RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLE 93
Query: 527 LVKDENSTQKRLSVKQTRTLQLDEDVLC-VSYSPNQKLLAVSLLDCTVKIFYVDTLKFFL 585
+ K RTL + +C + + P + +A D +K++ +
Sbjct: 94 ------------AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVF 141
Query: 586 SLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKS 645
GH V C+ S DG +A+ + D VK+W L G H V ++F P
Sbjct: 142 RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNE 201
Query: 646 HLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRL--WE 703
+L + D I+ WD +KF+ + +EG + + +P G + S D SLR+ WE
Sbjct: 202 YLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWE 260
Query: 704 RTR 706
R
Sbjct: 261 PER 263
Score = 82.4 bits (202), Expect = 2e-15
Identities = 42/151 (27%), Positives = 75/151 (49%)
Query: 562 KLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLD 621
+LLA DC V ++ ++ +SL GH PV + ++ LI GS ++++W L+
Sbjct: 34 RLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLE 93
Query: 622 FGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCL 681
++L H ++ L F P + +D IK WD + + GH Q + CL
Sbjct: 94 AAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCL 153
Query: 682 AVSPSGDYVVSSSHDKSLRLWERTREPLILE 712
SP G ++ S++ D +++LW+ T ++ E
Sbjct: 154 RFSPDGKWLASAADDHTVKLWDLTAGKMMSE 184
Score = 76.3 bits (186), Expect = 1e-13
Identities = 51/216 (23%), Positives = 88/216 (40%), Gaps = 12/216 (5%)
Query: 489 LETIDAHDGALWSMSLSPDQ-RGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQ 547
L+ I AH + S+ L R TGG D V W S S ++ L
Sbjct: 13 LQEIVAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLN 72
Query: 548 LDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIA 607
E+++ +++++ ++ K +L GHK + +D G +A
Sbjct: 73 TPEELIVAGSQSG-----------SIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVA 121
Query: 608 TGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEH 667
+GS D N+K+W + C H +V L+F P +A DH +K WD +
Sbjct: 122 SGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKM 181
Query: 668 IQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
+ GH + + P+ + S S D+++R W+
Sbjct: 182 MSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWD 217
Score = 64.7 bits (156), Expect = 4e-10
Identities = 32/105 (30%), Positives = 52/105 (49%)
Query: 603 GALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDA 662
G L+ATG D V +W ++ +C SL H V ++ L + I+ WD
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDL 92
Query: 663 DKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTRE 707
+ + ++TL GH I L P G++V S S D +++LW+ R+
Sbjct: 93 EAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRK 137
Score = 61.6 bits (148), Expect = 3e-09
Identities = 50/220 (22%), Positives = 101/220 (45%), Gaps = 15/220 (6%)
Query: 409 ITIGGHRSDVRTLSFSS-DNIAVLSAAADSIKIWNRSTLQCIRTMTCEYA-LCSF-FVPG 465
+++ GH S V ++ ++ + + V + + SI++W+ + +RT+ A +CS F P
Sbjct: 57 MSLTGHTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPY 116
Query: 466 DRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDF 525
V G++ ++L+D+ + H A+ + SPD + + D +VK WD
Sbjct: 117 GEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDL 176
Query: 526 ELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFL 585
+ K +S T V V + PN+ LLA D T++ + ++ +
Sbjct: 177 -------TAGKMMSEFPGHT----GPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVS 225
Query: 586 SLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDC 625
+ G PV + + DG + +G D +++++G + C
Sbjct: 226 CIEGEPGPVRSVLFNPDGCCLYSGCQD-SLRVYGWEPERC 264
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 93.2 bits (230), Expect = 1e-18
Identities = 68/243 (27%), Positives = 105/243 (43%), Gaps = 11/243 (4%)
Query: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518
C F +Q+ G+ L ++ + + H A+ ++ SP +G DK
Sbjct: 24 CVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDK 83
Query: 519 SVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV 578
+V+ W VK E ST R R++ D Q + S D TVK++
Sbjct: 84 TVRIW-VPNVKGE-STVFRAHTATVRSVHFCSD--------GQSFVTASD-DKTVKVWAT 132
Query: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
KF SL H V C S DG LI + S D+ VK+W +C S H V Y
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192
Query: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698
+ F P AG D+ +K WD +Q + H + L+ PSG+Y++++S D +
Sbjct: 193 VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
Query: 699 LRL 701
L++
Sbjct: 253 LKI 255
Score = 86.3 bits (212), Expect = 1e-16
Identities = 47/154 (30%), Positives = 77/154 (50%)
Query: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611
V CV +S N K LA +D + ++++ GHK V C++ S G L+A+GS
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 612 DRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTL 671
D+ V+IW + AH +V + F F TA D +K W + + + +L
Sbjct: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
Query: 672 EGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705
H + C SP G +VS+S DK+++LW+++
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Score = 83.6 bits (205), Expect = 8e-16
Identities = 70/294 (23%), Positives = 117/294 (39%), Gaps = 14/294 (4%)
Query: 413 GHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTMTC--EYALCSFFVPGDRQV 469
GHR V + FS + + S + DS + +W+ T + C F P +
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 470 VIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVK 529
G++ ++++ AH + S+ D + FVT DK+VK W K
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
Query: 530 DENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYG 589
S + ++ V C +SP+ +L+ + D TVK++ + + S
Sbjct: 137 FLFSLSQHINW-----------VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 185
Query: 590 HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFF 649
H V +D G IA D VK+W + + H +V L F P +
Sbjct: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 245
Query: 650 TAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
TA D +K D + + TL GH +A S +G+Y S D+ + +W+
Sbjct: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 71.2 bits (173), Expect = 4e-12
Identities = 50/212 (23%), Positives = 94/212 (44%), Gaps = 14/212 (6%)
Query: 414 HRSDVRTLSFSSDNIAVLSAAAD-SIKIW--NRSTLQCIRTMTCEYALCSFFVPGDRQVV 470
H + VR++ F SD + ++A+ D ++K+W +R + + C+ F P R +V
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIV 161
Query: 471 IGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKD 530
+ ++L+D +S + + H G + + P G D +VK WD
Sbjct: 162 SASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR---- 217
Query: 531 ENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590
T + L Q + ++ +S+ P+ L + D T+KI + + +L+GH
Sbjct: 218 ---THRLLQHYQLHSAAVNG----LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270
Query: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDF 622
+ P + S G A+G +D V +W +F
Sbjct: 271 QGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302
Score = 70.5 bits (171), Expect = 7e-12
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 2/175 (1%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIF-SLLSGEGNVTFNG 105
+ +W ++ + G K VTC+ SP G LA G D ++RI+ + GE V F
Sbjct: 43 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV-FRA 101
Query: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
H A + ++ + G + S D + VW + L+ L H + + A F + L+V
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIV 161
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
++ D VK WD ++ C + H V + + D+ ++VWD+
Sbjct: 162 SASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Score = 67.0 bits (162), Expect = 8e-11
Identities = 35/116 (30%), Positives = 59/116 (50%)
Query: 103 FNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
F GH+ A+T + + +LASGS D+ ++VW + +S YR GHKDA+T F +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
LL + +D V+ W + + H V + S+ + +T + D ++VW
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Score = 63.2 bits (152), Expect = 1e-09
Identities = 47/161 (29%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 62 QGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGR 121
+G + VTC+ S + LA G D + ++ + F GHK A+T + + G
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 122 LASGSKDTDIIVW--DVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLD 179
LASGS+D + +W +V ES ++R H + F + VT+ D VK W
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
Query: 180 TQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSE-LRVWD 219
Q ++ H V S + RLI ASD + +++WD
Sbjct: 134 RQKFLFSLSQHINWV-RCAKFSPDGRLIVSASDDKTVKLWD 173
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/199 (23%), Positives = 81/199 (40%), Gaps = 2/199 (1%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V +W + + + L V C SPDG + +D +++++ S E ++ H
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH 186
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+T + + G +A+ D + VWDV L + H A+ F N L+T
Sbjct: 187 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 167 SGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW--DIAYLQ 224
+ D+ +K DL T+ GH+ + + +G SD ++ VW + +
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 306
Query: 225 EIEDPEEPDPKKIKGSSPG 243
E + P P SS G
Sbjct: 307 HGEVTKVPRPPATLASSMG 325
Score = 53.9 bits (128), Expect = 7e-07
Identities = 28/122 (22%), Positives = 53/122 (43%)
Query: 589 GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLF 648
GH+ V C+D S + +A+GS D + +W + H D+V + F P HL
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 649 FTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREP 708
+ +D ++ W + H + + G V++S DK++++W R+
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
Query: 709 LI 710
+
Sbjct: 137 FL 138
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 93.2 bits (230), Expect = 1e-18
Identities = 68/243 (27%), Positives = 105/243 (43%), Gaps = 11/243 (4%)
Query: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518
C F +Q+ G+ L ++ + + H A+ ++ SP +G DK
Sbjct: 24 CVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDK 83
Query: 519 SVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV 578
+V+ W VK E ST R R++ D Q + S D TVK++
Sbjct: 84 TVRIW-VPNVKGE-STVFRAHTATVRSVHFCSD--------GQSFVTASD-DKTVKVWAT 132
Query: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
KF SL H V C S DG LI + S D+ VK+W +C S H V Y
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTY 192
Query: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698
+ F P AG D+ +K WD +Q + H + L+ PSG+Y++++S D +
Sbjct: 193 VDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDST 252
Query: 699 LRL 701
L++
Sbjct: 253 LKI 255
Score = 86.3 bits (212), Expect = 1e-16
Identities = 47/154 (30%), Positives = 77/154 (50%)
Query: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611
V CV +S N K LA +D + ++++ GHK V C++ S G L+A+GS
Sbjct: 22 VTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSR 81
Query: 612 DRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTL 671
D+ V+IW + AH +V + F F TA D +K W + + + +L
Sbjct: 82 DKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSL 141
Query: 672 EGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705
H + C SP G +VS+S DK+++LW+++
Sbjct: 142 SQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 175
Score = 83.6 bits (205), Expect = 8e-16
Identities = 70/294 (23%), Positives = 117/294 (39%), Gaps = 14/294 (4%)
Query: 413 GHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTMTC--EYALCSFFVPGDRQV 469
GHR V + FS + + S + DS + +W+ T + C F P +
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 470 VIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVK 529
G++ ++++ AH + S+ D + FVT DK+VK W K
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
Query: 530 DENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYG 589
S + ++ V C +SP+ +L+ + D TVK++ + + S
Sbjct: 137 FLFSLSQHINW-----------VRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCE 185
Query: 590 HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFF 649
H V +D G IA D VK+W + + H +V L F P +
Sbjct: 186 HGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLI 245
Query: 650 TAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
TA D +K D + + TL GH +A S +G+Y S D+ + +W+
Sbjct: 246 TASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 71.2 bits (173), Expect = 4e-12
Identities = 50/212 (23%), Positives = 94/212 (44%), Gaps = 14/212 (6%)
Query: 414 HRSDVRTLSFSSDNIAVLSAAAD-SIKIW--NRSTLQCIRTMTCEYALCSFFVPGDRQVV 470
H + VR++ F SD + ++A+ D ++K+W +R + + C+ F P R +V
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIV 161
Query: 471 IGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKD 530
+ ++L+D +S + + H G + + P G D +VK WD
Sbjct: 162 SASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR---- 217
Query: 531 ENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590
T + L Q + ++ +S+ P+ L + D T+KI + + +L+GH
Sbjct: 218 ---THRLLQHYQLHSAAVNG----LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 270
Query: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDF 622
+ P + S G A+G +D V +W +F
Sbjct: 271 QGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 302
Score = 70.5 bits (171), Expect = 7e-12
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 2/175 (1%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIF-SLLSGEGNVTFNG 105
+ +W ++ + G K VTC+ SP G LA G D ++RI+ + GE V F
Sbjct: 43 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV-FRA 101
Query: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
H A + ++ + G + S D + VW + L+ L H + + A F + L+V
Sbjct: 102 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIV 161
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
++ D VK WD ++ C + H V + + D+ ++VWD+
Sbjct: 162 SASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216
Score = 67.0 bits (162), Expect = 8e-11
Identities = 35/116 (30%), Positives = 59/116 (50%)
Query: 103 FNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
F GH+ A+T + + +LASGS D+ ++VW + +S YR GHKDA+T F +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
LL + +D V+ W + + H V + S+ + +T + D ++VW
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Score = 63.2 bits (152), Expect = 1e-09
Identities = 47/161 (29%), Positives = 74/161 (45%), Gaps = 6/161 (3%)
Query: 62 QGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGR 121
+G + VTC+ S + LA G D + ++ + F GHK A+T + + G
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHL 75
Query: 122 LASGSKDTDIIVW--DVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLD 179
LASGS+D + +W +V ES ++R H + F + VT+ D VK W
Sbjct: 76 LASGSRDKTVRIWVPNVKGESTVFR--AHTATVRSVHFCSDGQSFVTASDDKTVKVWATH 133
Query: 180 TQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSE-LRVWD 219
Q ++ H V S + RLI ASD + +++WD
Sbjct: 134 RQKFLFSLSQHINWV-RCAKFSPDGRLIVSASDDKTVKLWD 173
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/199 (23%), Positives = 81/199 (40%), Gaps = 2/199 (1%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V +W + + + L V C SPDG + +D +++++ S E ++ H
Sbjct: 127 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH 186
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+T + + G +A+ D + VWDV L + H A+ F N L+T
Sbjct: 187 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 246
Query: 167 SGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW--DIAYLQ 224
+ D+ +K DL T+ GH+ + + +G SD ++ VW + +
Sbjct: 247 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 306
Query: 225 EIEDPEEPDPKKIKGSSPG 243
E + P P SS G
Sbjct: 307 HGEVTKVPRPPATLASSMG 325
Score = 53.9 bits (128), Expect = 7e-07
Identities = 28/122 (22%), Positives = 53/122 (43%)
Query: 589 GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLF 648
GH+ V C+D S + +A+GS D + +W + H D+V + F P HL
Sbjct: 17 GHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLL 76
Query: 649 FTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREP 708
+ +D ++ W + H + + G V++S DK++++W R+
Sbjct: 77 ASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQK 136
Query: 709 LI 710
+
Sbjct: 137 FL 138
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 93.2 bits (230), Expect = 1e-18
Identities = 82/318 (25%), Positives = 135/318 (42%), Gaps = 19/318 (5%)
Query: 394 LNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTM 452
+N +P VR + G H +V + +FS D +L+ + D + W + Q + +
Sbjct: 1 MNSGVPATLAVRRVKF-FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL 59
Query: 453 TCEYALCSF--FVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRG 510
F F P + ++L+D+A L + H ++ ++S SPD R
Sbjct: 60 GGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQ 119
Query: 511 FVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLD 570
+GG DK V WD + + RL V ++Q + +SP LA D
Sbjct: 120 LASGGWDKRVMLWDVQ-----SGQMLRLLVGHRDSIQSSD------FSPTVNCLATGSWD 168
Query: 571 CTVKIFYVDTLKFFLS---LYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHK 627
TV I+ + + +S L GH + C+ S G L+A+GS D+ + IW
Sbjct: 169 STVHIWDLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLI 227
Query: 628 SLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSG 687
L H V + F P +AG +K WD + + ++TL+G A +P G
Sbjct: 228 QLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDG 287
Query: 688 DYVVSSSHDKSLRLWERT 705
+VS + D++ R RT
Sbjct: 288 KILVSGAADQTRRQISRT 305
Score = 89.0 bits (219), Expect = 2e-17
Identities = 67/229 (29%), Positives = 98/229 (42%), Gaps = 31/229 (13%)
Query: 495 HDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQL------ 548
H G + S + SPD + +TG D V W+ TR+ QL
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWE------------------TRSGQLLWRLGG 61
Query: 549 -DEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIA 607
V +SP+ L A + DCTV+++ V K L GH+ V + S D +A
Sbjct: 62 HTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLA 121
Query: 608 TGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWD----AD 663
+G D+ V +W + G + L H DS+ F P + T D + WD
Sbjct: 122 SGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTP 181
Query: 664 KFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILE 712
H Q LEGH I CL S SG + S S DK++ +W+ T L+++
Sbjct: 182 AVSH-QALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQ 228
Score = 78.6 bits (192), Expect = 3e-14
Identities = 53/175 (30%), Positives = 81/175 (46%), Gaps = 4/175 (2%)
Query: 45 EHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSL---LSGEGNV 101
+ V +WD++ G+ + +L G + + SP LA G D ++ I+ L +
Sbjct: 127 KRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQ 186
Query: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREK 161
GH A I+ L Y G LASGS D I +W S L +LKGH + F ++
Sbjct: 187 ALEGHSANISCLCYSA-SGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
Query: 162 NLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELR 216
L ++G MVK WD +T C +T+ G + K L++GA+D R
Sbjct: 246 LWLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Score = 78.2 bits (191), Expect = 3e-14
Identities = 46/154 (29%), Positives = 68/154 (44%)
Query: 67 EVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGS 126
EV SPDG L G EDG + + SG+ GH + ++ G AS S
Sbjct: 23 EVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82
Query: 127 KDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKT 186
D + +WDV L LKGH+ ++ F + L + G D V WD+ + +
Sbjct: 83 CDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRL 142
Query: 187 MVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
+VGHR + L TG+ DS + +WD+
Sbjct: 143 LVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDL 176
Score = 67.8 bits (164), Expect = 5e-11
Identities = 47/175 (26%), Positives = 79/175 (45%), Gaps = 4/175 (2%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V+ W+ R G+ + L G V SPDG A D ++R++ + + GH
Sbjct: 45 VYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGH 104
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+ ++ T+ + +LASG D +++WDV + L L GH+D+I + F N L T
Sbjct: 105 QRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLAT 164
Query: 167 SGKDTMVKWWDL---DTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
D+ V WDL + + GH + + S L +G+ D + +W
Sbjct: 165 GSWDSTVHIWDLRMVTPAVSHQALEGHSANI-SCLCYSASGLLASGSWDKTIHIW 218
Score = 57.8 bits (138), Expect = 5e-08
Identities = 28/118 (23%), Positives = 55/118 (46%)
Query: 103 FNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
F H + + + G L +GS+D + W+ + L+RL GH + F + +
Sbjct: 17 FGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGH 76
Query: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
L ++ D V+ WD+ C + + GH+ V + + ++L +G D + +WD+
Sbjct: 77 LFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Score = 38.1 bits (87), Expect = 0.039
Identities = 25/96 (26%), Positives = 40/96 (41%), Gaps = 11/96 (11%)
Query: 611 ADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQT 670
A R VK +G G+ + S F+ P + T +D + W+ + +
Sbjct: 10 AVRRVKFFGQHGGEVNSSAFS-----------PDGQMLLTGSEDGCVYGWETRSGQLLWR 58
Query: 671 LEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTR 706
L GH + SP G S+S D ++RLW+ R
Sbjct: 59 LGGHTGPVKFCRFSPDGHLFASASCDCTVRLWDVAR 94
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 92.4 bits (228), Expect = 2e-18
Identities = 83/361 (22%), Positives = 160/361 (44%), Gaps = 36/361 (9%)
Query: 346 EMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVR 405
E ++ I +IK IK IHSP K+ ++ Q+ ++ L +P+ ++
Sbjct: 205 EKCKEEGIDEPLHIKRRKVIKP-GFIHSPW---KSAYIRQHR-IDTNWRRGELKSPKVLK 259
Query: 406 TSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPG 465
GH V T N V + +++K+W+ T +C+RT+
Sbjct: 260 -------GHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR 312
Query: 466 DRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDF 525
D ++ G+ L++++ +G + T+ H + M L ++ V+G D +++ WD
Sbjct: 313 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDI 370
Query: 526 ELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFL 585
E T + L V V CV Y + + + D VK++ +T
Sbjct: 371 E-------TGQCLHVLMGHVAA----VRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 417
Query: 586 SLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKS 645
+L GH V + DG + +GS D ++++W ++ G+C +L H ++ K
Sbjct: 418 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KD 473
Query: 646 HLFFTAGKDHKIKQWDADKFEHIQTLEG---HHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
++ + D +K WD + +QTL+G H + CL + ++V++SS D +++LW
Sbjct: 474 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 531
Query: 703 E 703
+
Sbjct: 532 D 532
Score = 89.7 bits (221), Expect = 1e-17
Identities = 58/190 (30%), Positives = 101/190 (53%), Gaps = 19/190 (10%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLH---LAVGYEDGSIRIFSLLSGEGNVTFNG 105
+W+ GE I L G V C+ LH + G D ++R++ + +G+ G
Sbjct: 327 VWNAETGECIHTLYGHTSTVRCM-----HLHEKRVVSGSRDATLRVWDIETGQCLHVLMG 381
Query: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
H AA+ ++YD G R+ SG+ D + VWD E+ L+ L+GH + + F + V
Sbjct: 382 HVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHV 436
Query: 166 TSGK-DTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI---A 221
SG DT ++ WD++T +C T+ GH++ G+ L ++ L++G +DS +++WDI
Sbjct: 437 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQ 494
Query: 222 YLQEIEDPEE 231
LQ ++ P +
Sbjct: 495 CLQTLQGPNK 504
Score = 86.7 bits (213), Expect = 1e-16
Identities = 72/265 (27%), Positives = 124/265 (46%), Gaps = 23/265 (8%)
Query: 410 TIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQV 469
T+ GH V + S DNI + + ++K+WN T +CI T+ + +++V
Sbjct: 298 TLVGHTGGVWS-SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRV 356
Query: 470 VIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVK 529
V G++ L+++D+ +G L + H A+ + D R V+G D VK WD E
Sbjct: 357 VSGSRDATLRVWDIETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETET 414
Query: 530 DENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYG 589
++ Q + +LQ D + VS S LD +++++ V+T +L G
Sbjct: 415 CLHTLQGH--TNRVYSLQFD-GIHVVSGS----------LDTSIRVWDVETGNCIHTLTG 461
Query: 590 HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFA---HDDSVMYLQFVPKSH 646
H+ M++ + ++ +G+AD VKIW + G C ++L H +V LQF +
Sbjct: 462 HQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF--NKN 517
Query: 647 LFFTAGKDHKIKQWDADKFEHIQTL 671
T+ D +K WD E I+ L
Sbjct: 518 FVITSSDDGTVKLWDLKTGEFIRNL 542
Score = 82.8 bits (203), Expect = 1e-15
Identities = 51/173 (29%), Positives = 90/173 (52%), Gaps = 7/173 (4%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+WD+ G+ + +L G V C+ DG + G D ++++ + T GH
Sbjct: 367 VWDIETGQCLHVLMGHVAAVRCV--QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN 424
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSG 168
+ +L++D G + SGS DT I VWDV + ++ L GH+ ++T + L++ N+LV+
Sbjct: 425 RVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-SLTSGMELKD-NILVSGN 480
Query: 169 KDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKR-LITGASDSELRVWDI 220
D+ VK WD+ T C +T+ G + L K +IT + D +++WD+
Sbjct: 481 ADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 533
Score = 71.2 bits (173), Expect = 4e-12
Identities = 40/138 (28%), Positives = 73/138 (52%), Gaps = 6/138 (4%)
Query: 83 GYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGL 142
G D ++++++ +GE T GH + + + + R+ SGS+D + VWD+ L
Sbjct: 319 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQCL 376
Query: 143 YRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSE 202
+ L GH A+ + + +V+ D MVK WD +T+ C T+ GH V+ L +
Sbjct: 377 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--D 432
Query: 203 EKRLITGASDSELRVWDI 220
+++G+ D+ +RVWD+
Sbjct: 433 GIHVVSGSLDTSIRVWDV 450
Score = 67.4 bits (163), Expect = 6e-11
Identities = 37/111 (33%), Positives = 59/111 (53%), Gaps = 6/111 (5%)
Query: 110 ITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGK 169
IT L++ G R+ SGS D + VW + L L GH + + N++++
Sbjct: 266 ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGST 321
Query: 170 DTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
D +K W+ +T C T+ GH + V + L EKR+++G+ D+ LRVWDI
Sbjct: 322 DRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDI 370
Score = 64.7 bits (156), Expect = 4e-10
Identities = 51/169 (30%), Positives = 79/169 (46%), Gaps = 10/169 (5%)
Query: 24 GNIVFVTLRGEKGRYVAVPACEH-VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAV 82
G++ V GR V A + V +WD + LQG V L DG+H+
Sbjct: 381 GHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSL--QFDGIHVVS 438
Query: 83 GYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGL 142
G D SIR++ + +G T GH++ + ++ L SG+ D+ + +WD+ L
Sbjct: 439 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNADSTVKIWDIKTGQCL 496
Query: 143 YRLKG---HKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMV 188
L+G H+ A+T F KN ++TS D VK WDL T + +V
Sbjct: 497 QTLQGPNKHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNLV 543
Score = 61.6 bits (148), Expect = 3e-09
Identities = 43/174 (24%), Positives = 83/174 (47%), Gaps = 10/174 (5%)
Query: 536 KRLSVKQTRTLQLDED--VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLP 593
+R +K + L+ +D + C+ + N+ + D T+K++ T K +L GH
Sbjct: 248 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSD--DNTLKVWSAVTGKCLRTLVGHTGG 305
Query: 594 VICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGK 653
V + + +I +GS DR +K+W + G+C +L+ H +V + K + +
Sbjct: 306 VWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSR 361
Query: 654 DHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTRE 707
D ++ WD + + + L GH + C V G VVS ++D +++W+ E
Sbjct: 362 DATLRVWDIETGQCLHVLMGHVAAVRC--VQYDGRRVVSGAYDFMVKVWDPETE 413
Score = 46.6 bits (109), Expect = 1e-04
Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 145 LKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEK 204
LKGH D + L N +V+ D +K W T C +T+VGH VW + +
Sbjct: 258 LKGHDDHVITCLQFCG-NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDN 314
Query: 205 RLITGASDSELRVWD 219
+I+G++D L+VW+
Sbjct: 315 IIISGSTDRTLKVWN 329
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 92.4 bits (228), Expect = 2e-18
Identities = 83/361 (22%), Positives = 160/361 (44%), Gaps = 36/361 (9%)
Query: 346 EMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVR 405
E ++ I +IK IK IHSP K+ ++ Q+ ++ L +P+ ++
Sbjct: 323 EKCKEEGIDEPLHIKRRKVIKP-GFIHSPW---KSAYIRQHR-IDTNWRRGELKSPKVLK 377
Query: 406 TSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPG 465
GH V T N V + +++K+W+ T +C+RT+
Sbjct: 378 -------GHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR 430
Query: 466 DRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDF 525
D ++ G+ L++++ +G + T+ H + M L ++ V+G D +++ WD
Sbjct: 431 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDI 488
Query: 526 ELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFL 585
E T + L V V CV Y + + + D VK++ +T
Sbjct: 489 E-------TGQCLHVLMGHVAA----VRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 535
Query: 586 SLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKS 645
+L GH V + DG + +GS D ++++W ++ G+C +L H ++ K
Sbjct: 536 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KD 591
Query: 646 HLFFTAGKDHKIKQWDADKFEHIQTLEG---HHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
++ + D +K WD + +QTL+G H + CL + ++V++SS D +++LW
Sbjct: 592 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 649
Query: 703 E 703
+
Sbjct: 650 D 650
Score = 89.7 bits (221), Expect = 1e-17
Identities = 58/190 (30%), Positives = 101/190 (53%), Gaps = 19/190 (10%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLH---LAVGYEDGSIRIFSLLSGEGNVTFNG 105
+W+ GE I L G V C+ LH + G D ++R++ + +G+ G
Sbjct: 445 VWNAETGECIHTLYGHTSTVRCM-----HLHEKRVVSGSRDATLRVWDIETGQCLHVLMG 499
Query: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
H AA+ ++YD G R+ SG+ D + VWD E+ L+ L+GH + + F + V
Sbjct: 500 HVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHV 554
Query: 166 TSGK-DTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI---A 221
SG DT ++ WD++T +C T+ GH++ G+ L ++ L++G +DS +++WDI
Sbjct: 555 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQ 612
Query: 222 YLQEIEDPEE 231
LQ ++ P +
Sbjct: 613 CLQTLQGPNK 622
Score = 86.7 bits (213), Expect = 1e-16
Identities = 72/265 (27%), Positives = 124/265 (46%), Gaps = 23/265 (8%)
Query: 410 TIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQV 469
T+ GH V + S DNI + + ++K+WN T +CI T+ + +++V
Sbjct: 416 TLVGHTGGVWS-SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRV 474
Query: 470 VIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVK 529
V G++ L+++D+ +G L + H A+ + D R V+G D VK WD E
Sbjct: 475 VSGSRDATLRVWDIETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETET 532
Query: 530 DENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYG 589
++ Q + +LQ D + VS S LD +++++ V+T +L G
Sbjct: 533 CLHTLQGH--TNRVYSLQFD-GIHVVSGS----------LDTSIRVWDVETGNCIHTLTG 579
Query: 590 HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFA---HDDSVMYLQFVPKSH 646
H+ M++ + ++ +G+AD VKIW + G C ++L H +V LQF +
Sbjct: 580 HQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF--NKN 635
Query: 647 LFFTAGKDHKIKQWDADKFEHIQTL 671
T+ D +K WD E I+ L
Sbjct: 636 FVITSSDDGTVKLWDLKTGEFIRNL 660
Score = 82.8 bits (203), Expect = 1e-15
Identities = 51/173 (29%), Positives = 90/173 (52%), Gaps = 7/173 (4%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+WD+ G+ + +L G V C+ DG + G D ++++ + T GH
Sbjct: 485 VWDIETGQCLHVLMGHVAAVRCV--QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN 542
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSG 168
+ +L++D G + SGS DT I VWDV + ++ L GH+ ++T + L++ N+LV+
Sbjct: 543 RVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-SLTSGMELKD-NILVSGN 598
Query: 169 KDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKR-LITGASDSELRVWDI 220
D+ VK WD+ T C +T+ G + L K +IT + D +++WD+
Sbjct: 599 ADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 651
Score = 71.2 bits (173), Expect = 4e-12
Identities = 40/138 (28%), Positives = 73/138 (52%), Gaps = 6/138 (4%)
Query: 83 GYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGL 142
G D ++++++ +GE T GH + + + + R+ SGS+D + VWD+ L
Sbjct: 437 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQCL 494
Query: 143 YRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSE 202
+ L GH A+ + + +V+ D MVK WD +T+ C T+ GH V+ L +
Sbjct: 495 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--D 550
Query: 203 EKRLITGASDSELRVWDI 220
+++G+ D+ +RVWD+
Sbjct: 551 GIHVVSGSLDTSIRVWDV 568
Score = 67.4 bits (163), Expect = 6e-11
Identities = 37/111 (33%), Positives = 59/111 (53%), Gaps = 6/111 (5%)
Query: 110 ITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGK 169
IT L++ G R+ SGS D + VW + L L GH + + N++++
Sbjct: 384 ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGST 439
Query: 170 DTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
D +K W+ +T C T+ GH + V + L EKR+++G+ D+ LRVWDI
Sbjct: 440 DRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDI 488
Score = 64.7 bits (156), Expect = 4e-10
Identities = 51/169 (30%), Positives = 79/169 (46%), Gaps = 10/169 (5%)
Query: 24 GNIVFVTLRGEKGRYVAVPACEH-VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAV 82
G++ V GR V A + V +WD + LQG V L DG+H+
Sbjct: 499 GHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSL--QFDGIHVVS 556
Query: 83 GYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGL 142
G D SIR++ + +G T GH++ + ++ L SG+ D+ + +WD+ L
Sbjct: 557 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNADSTVKIWDIKTGQCL 614
Query: 143 YRLKG---HKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMV 188
L+G H+ A+T F KN ++TS D VK WDL T + +V
Sbjct: 615 QTLQGPNKHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNLV 661
Score = 61.6 bits (148), Expect = 3e-09
Identities = 43/174 (24%), Positives = 83/174 (47%), Gaps = 10/174 (5%)
Query: 536 KRLSVKQTRTLQLDED--VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLP 593
+R +K + L+ +D + C+ + N+ + D T+K++ T K +L GH
Sbjct: 366 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSD--DNTLKVWSAVTGKCLRTLVGHTGG 423
Query: 594 VICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGK 653
V + + +I +GS DR +K+W + G+C +L+ H +V + K + +
Sbjct: 424 VWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSR 479
Query: 654 DHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTRE 707
D ++ WD + + + L GH + C V G VVS ++D +++W+ E
Sbjct: 480 DATLRVWDIETGQCLHVLMGHVAAVRC--VQYDGRRVVSGAYDFMVKVWDPETE 531
Score = 46.6 bits (109), Expect = 1e-04
Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 145 LKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEK 204
LKGH D + L N +V+ D +K W T C +T+VGH VW + +
Sbjct: 376 LKGHDDHVITCLQFCG-NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDN 432
Query: 205 RLITGASDSELRVWD 219
+I+G++D L+VW+
Sbjct: 433 IIISGSTDRTLKVWN 447
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 92.4 bits (228), Expect = 2e-18
Identities = 83/361 (22%), Positives = 160/361 (44%), Gaps = 36/361 (9%)
Query: 346 EMSLQDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSLNPSLPTPQPVR 405
E ++ I +IK IK IHSP K+ ++ Q+ ++ L +P+ ++
Sbjct: 243 EKCKEEGIDEPLHIKRRKVIKP-GFIHSPW---KSAYIRQHR-IDTNWRRGELKSPKVLK 297
Query: 406 TSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPG 465
GH V T N V + +++K+W+ T +C+RT+
Sbjct: 298 -------GHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMR 350
Query: 466 DRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDF 525
D ++ G+ L++++ +G + T+ H + M L ++ V+G D +++ WD
Sbjct: 351 DNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDI 408
Query: 526 ELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFL 585
E T + L V V CV Y + + + D VK++ +T
Sbjct: 409 E-------TGQCLHVLMGHVAA----VRCVQY--DGRRVVSGAYDFMVKVWDPETETCLH 455
Query: 586 SLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKS 645
+L GH V + DG + +GS D ++++W ++ G+C +L H ++ K
Sbjct: 456 TLQGHTNRV--YSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KD 511
Query: 646 HLFFTAGKDHKIKQWDADKFEHIQTLEG---HHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
++ + D +K WD + +QTL+G H + CL + ++V++SS D +++LW
Sbjct: 512 NILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNK--NFVITSSDDGTVKLW 569
Query: 703 E 703
+
Sbjct: 570 D 570
Score = 89.7 bits (221), Expect = 1e-17
Identities = 58/190 (30%), Positives = 101/190 (53%), Gaps = 19/190 (10%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLH---LAVGYEDGSIRIFSLLSGEGNVTFNG 105
+W+ GE I L G V C+ LH + G D ++R++ + +G+ G
Sbjct: 365 VWNAETGECIHTLYGHTSTVRCM-----HLHEKRVVSGSRDATLRVWDIETGQCLHVLMG 419
Query: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
H AA+ ++YD G R+ SG+ D + VWD E+ L+ L+GH + + F + V
Sbjct: 420 HVAAVRCVQYD--GRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF---DGIHV 474
Query: 166 TSGK-DTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI---A 221
SG DT ++ WD++T +C T+ GH++ G+ L ++ L++G +DS +++WDI
Sbjct: 475 VSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMEL--KDNILVSGNADSTVKIWDIKTGQ 532
Query: 222 YLQEIEDPEE 231
LQ ++ P +
Sbjct: 533 CLQTLQGPNK 542
Score = 86.7 bits (213), Expect = 1e-16
Identities = 72/265 (27%), Positives = 124/265 (46%), Gaps = 23/265 (8%)
Query: 410 TIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQV 469
T+ GH V + S DNI + + ++K+WN T +CI T+ + +++V
Sbjct: 336 TLVGHTGGVWS-SQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRV 394
Query: 470 VIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVK 529
V G++ L+++D+ +G L + H A+ + D R V+G D VK WD E
Sbjct: 395 VSGSRDATLRVWDIETGQCLHVLMGHVAAV--RCVQYDGRRVVSGAYDFMVKVWDPETET 452
Query: 530 DENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYG 589
++ Q + +LQ D + VS S LD +++++ V+T +L G
Sbjct: 453 CLHTLQGH--TNRVYSLQFD-GIHVVSGS----------LDTSIRVWDVETGNCIHTLTG 499
Query: 590 HKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFA---HDDSVMYLQFVPKSH 646
H+ M++ + ++ +G+AD VKIW + G C ++L H +V LQF +
Sbjct: 500 HQSLTSGMELKDN--ILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQF--NKN 555
Query: 647 LFFTAGKDHKIKQWDADKFEHIQTL 671
T+ D +K WD E I+ L
Sbjct: 556 FVITSSDDGTVKLWDLKTGEFIRNL 580
Score = 82.8 bits (203), Expect = 1e-15
Identities = 51/173 (29%), Positives = 90/173 (52%), Gaps = 7/173 (4%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+WD+ G+ + +L G V C+ DG + G D ++++ + T GH
Sbjct: 405 VWDIETGQCLHVLMGHVAAVRCV--QYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTN 462
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSG 168
+ +L++D G + SGS DT I VWDV + ++ L GH+ ++T + L++ N+LV+
Sbjct: 463 RVYSLQFD--GIHVVSGSLDTSIRVWDVETGNCIHTLTGHQ-SLTSGMELKD-NILVSGN 518
Query: 169 KDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKR-LITGASDSELRVWDI 220
D+ VK WD+ T C +T+ G + L K +IT + D +++WD+
Sbjct: 519 ADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDL 571
Score = 71.2 bits (173), Expect = 4e-12
Identities = 40/138 (28%), Positives = 73/138 (52%), Gaps = 6/138 (4%)
Query: 83 GYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGL 142
G D ++++++ +GE T GH + + + + R+ SGS+D + VWD+ L
Sbjct: 357 GSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEK--RVVSGSRDATLRVWDIETGQCL 414
Query: 143 YRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSE 202
+ L GH A+ + + +V+ D MVK WD +T+ C T+ GH V+ L +
Sbjct: 415 HVLMGHVAAVRCVQY--DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--D 470
Query: 203 EKRLITGASDSELRVWDI 220
+++G+ D+ +RVWD+
Sbjct: 471 GIHVVSGSLDTSIRVWDV 488
Score = 67.4 bits (163), Expect = 6e-11
Identities = 37/111 (33%), Positives = 59/111 (53%), Gaps = 6/111 (5%)
Query: 110 ITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGK 169
IT L++ G R+ SGS D + VW + L L GH + + N++++
Sbjct: 304 ITCLQF--CGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDNIIISGST 359
Query: 170 DTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
D +K W+ +T C T+ GH + V + L EKR+++G+ D+ LRVWDI
Sbjct: 360 DRTLKVWNAETGECIHTLYGHTSTVRCMHL--HEKRVVSGSRDATLRVWDI 408
Score = 64.7 bits (156), Expect = 4e-10
Identities = 51/169 (30%), Positives = 79/169 (46%), Gaps = 10/169 (5%)
Query: 24 GNIVFVTLRGEKGRYVAVPACEH-VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAV 82
G++ V GR V A + V +WD + LQG V L DG+H+
Sbjct: 419 GHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSL--QFDGIHVVS 476
Query: 83 GYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGL 142
G D SIR++ + +G T GH++ + ++ L SG+ D+ + +WD+ L
Sbjct: 477 GSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKD--NILVSGNADSTVKIWDIKTGQCL 534
Query: 143 YRLKG---HKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMV 188
L+G H+ A+T F KN ++TS D VK WDL T + +V
Sbjct: 535 QTLQGPNKHQSAVTCLQF--NKNFVITSSDDGTVKLWDLKTGEFIRNLV 581
Score = 61.6 bits (148), Expect = 3e-09
Identities = 43/174 (24%), Positives = 83/174 (47%), Gaps = 10/174 (5%)
Query: 536 KRLSVKQTRTLQLDED--VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLP 593
+R +K + L+ +D + C+ + N+ + D T+K++ T K +L GH
Sbjct: 286 RRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSD--DNTLKVWSAVTGKCLRTLVGHTGG 343
Query: 594 VICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGK 653
V + + +I +GS DR +K+W + G+C +L+ H +V + K + +
Sbjct: 344 VWSSQMRDN--IIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKR--VVSGSR 399
Query: 654 DHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTRE 707
D ++ WD + + + L GH + C V G VVS ++D +++W+ E
Sbjct: 400 DATLRVWDIETGQCLHVLMGHVAAVRC--VQYDGRRVVSGAYDFMVKVWDPETE 451
Score = 46.6 bits (109), Expect = 1e-04
Identities = 25/75 (33%), Positives = 39/75 (52%), Gaps = 3/75 (4%)
Query: 145 LKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEK 204
LKGH D + L N +V+ D +K W T C +T+VGH VW + +
Sbjct: 296 LKGHDDHVITCLQFCG-NRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDN 352
Query: 205 RLITGASDSELRVWD 219
+I+G++D L+VW+
Sbjct: 353 IIISGSTDRTLKVWN 367
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 90.5 bits (223), Expect = 7e-18
Identities = 60/218 (27%), Positives = 106/218 (48%), Gaps = 14/218 (6%)
Query: 491 TIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQ-KRLSVKQTRTLQLD 549
T+ H A+ S+ SP+ + ADK +K W K E + +L +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD------- 92
Query: 550 EDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATG 609
V++S + LL + D T+KI+ V + K +L GH V C + + LI +G
Sbjct: 93 -----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 610 SADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQ 669
S D +V+IW + G C K+L AH D V + F L ++ D + WD + ++
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 670 TL-EGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTR 706
TL + + + + SP+G Y+++++ D +L+LW+ ++
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Score = 90.1 bits (222), Expect = 9e-18
Identities = 76/322 (23%), Positives = 148/322 (45%), Gaps = 23/322 (7%)
Query: 393 SLNPSLPTP-QPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIR 450
S S PTP +P + T+ GH V ++ FS + + S++AD IKIW + +
Sbjct: 22 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK 81
Query: 451 TMTC-EYALCSFFVPGDRQVVIGTKTGK-LQLYDLASGNLLETIDAHDGALWSMSLSPDQ 508
T++ + + D +++ K L+++D++SG L+T+ H ++ + +P
Sbjct: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141
Query: 509 RGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDED-VLCVSYSPNQKLLAVS 567
V+G D+SV+ WD + + K +TL D V V ++ + L+ S
Sbjct: 142 NLIVSGSFDESVRIWDVK------------TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189
Query: 568 LLDCTVKIFYVDTLKFFLSLY-GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCH 626
D +I+ + + +L PV + S +G I + D +K+W G C
Sbjct: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249
Query: 627 KSLFAHDDS--VMYLQFVPKSHLFFTAG-KDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 683
K+ H + ++ F + +G +D+ + W+ E +Q L+GH + A
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309
Query: 684 SPSGDYVVSSS--HDKSLRLWE 703
P+ + + S++ +DK+++LW+
Sbjct: 310 HPTENIIASAALENDKTIKLWK 331
Score = 84.7 bits (208), Expect = 4e-16
Identities = 54/186 (29%), Positives = 87/186 (46%), Gaps = 3/186 (1%)
Query: 61 LQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGG 120
L G + V+ + SP+G LA D I+I+ G+ T +GHK I+ + +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 121 RLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT 180
L S S D + +WDV + L LKGH + + F + NL+V+ D V+ WD+ T
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 181 QHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIA---YLQEIEDPEEPDPKKI 237
C KT+ H V + + +++ + D R+WD A L+ + D + P +
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 238 KGSSPG 243
K S G
Sbjct: 221 KFSPNG 226
Score = 74.7 bits (182), Expect = 4e-13
Identities = 36/119 (30%), Positives = 62/119 (52%)
Query: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREK 161
T GH A++++K+ G LAS S D I +W + + GHK I+ + +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 162 NLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
NLLV++ D +K WD+ + C KT+ GH V+ + +++G+ D +R+WD+
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Score = 74.3 bits (181), Expect = 5e-13
Identities = 47/186 (25%), Positives = 86/186 (46%), Gaps = 2/186 (1%)
Query: 36 GRYVAVPACEHVF-IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSL 94
G ++A + + + IW G+ + G K ++ + S D L +D +++I+ +
Sbjct: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Query: 95 LSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQ 154
SG+ T GH + ++ + SGS D + +WDV L L H D ++
Sbjct: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 155 ALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGAS-DS 213
F R+ +L+V+S D + + WD + C KT++ V S + I A+ D+
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236
Query: 214 ELRVWD 219
L++WD
Sbjct: 237 TLKLWD 242
Score = 64.3 bits (155), Expect = 5e-10
Identities = 40/176 (22%), Positives = 80/176 (45%), Gaps = 4/176 (2%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
IWD+ G+ + L+G V C +P + G D S+RI+ + +G+ T H
Sbjct: 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL-KGHKDAITQALFLREKNLLVTS 167
++ + +++ G + S S D +WD + L L ++ F ++ +
Sbjct: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232
Query: 168 GKDTMVKWWDLDTQHCFKTMVGHRTE---VWGLVLLSEEKRLITGASDSELRVWDI 220
D +K WD C KT GH+ E ++ ++ K +++G+ D+ + +W++
Sbjct: 233 TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 51.6 bits (122), Expect = 3e-06
Identities = 44/196 (22%), Positives = 87/196 (44%), Gaps = 10/196 (5%)
Query: 385 QNNLVELYSLNPSLPTPQPVRTSRI--TIGGHRSDVRTLSFSSDNIAVLSAAADSI-KIW 441
Q+NL+ S + S+ V+T + T+ H V + F+ D ++S++ D + +IW
Sbjct: 140 QSNLIVSGSFDESVRI-WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 442 NRSTLQCIRTMTCE-YALCSF--FVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGA 498
+ ++ QC++T+ + SF F P + ++ T L+L+D + G L+T H
Sbjct: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258
Query: 499 LWSMSLSPDQRG---FVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCV 555
+ + + G V+G D V W+ + + Q V + E+++
Sbjct: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
Query: 556 SYSPNQKLLAVSLLDC 571
+ N K + + DC
Sbjct: 319 AALENDKTIKLWKSDC 334
Score = 50.1 bits (118), Expect = 1e-05
Identities = 40/180 (22%), Positives = 76/180 (42%), Gaps = 6/180 (3%)
Query: 45 EHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTF- 103
E V IWD++ G+ + L V+ + + DG + DG RI+ SG+ T
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 104 NGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKD---AITQALFLRE 160
+ ++ +K+ G + + + D + +WD L GHK+ I +
Sbjct: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG 270
Query: 161 KNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGA--SDSELRVW 218
+V+ +D +V W+L T+ + + GH V E + + A +D +++W
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 48.5 bits (114), Expect = 3e-05
Identities = 30/137 (21%), Positives = 66/137 (48%), Gaps = 6/137 (4%)
Query: 49 IWDLRKGEKI-LILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHK 107
IWD G+ + ++ V+ + SP+G ++ D +++++ G+ T+ GHK
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 108 AAITTL--KYDQLGGR-LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLL 164
+ + GG+ + SGS+D + +W++ + + +L+GH D + +N++
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316
Query: 165 VTSG--KDTMVKWWDLD 179
++ D +K W D
Sbjct: 317 ASAALENDKTIKLWKSD 333
Score = 44.7 bits (104), Expect = 4e-04
Identities = 20/79 (25%), Positives = 38/79 (48%)
Query: 143 YRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSE 202
+ L GH A++ F L +S D ++K W KT+ GH+ + + S+
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 203 EKRLITGASDSELRVWDIA 221
L++ + D L++WD++
Sbjct: 99 SNLLVSASDDKTLKIWDVS 117
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 90.5 bits (223), Expect = 7e-18
Identities = 60/218 (27%), Positives = 106/218 (48%), Gaps = 14/218 (6%)
Query: 491 TIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQ-KRLSVKQTRTLQLD 549
T+ H A+ S+ SP+ + ADK +K W K E + +L +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISD------- 92
Query: 550 EDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATG 609
V++S + LL + D T+KI+ V + K +L GH V C + + LI +G
Sbjct: 93 -----VAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSG 147
Query: 610 SADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQ 669
S D +V+IW + G C K+L AH D V + F L ++ D + WD + ++
Sbjct: 148 SFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLK 207
Query: 670 TL-EGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTR 706
TL + + + + SP+G Y+++++ D +L+LW+ ++
Sbjct: 208 TLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSK 245
Score = 90.1 bits (222), Expect = 9e-18
Identities = 76/322 (23%), Positives = 148/322 (45%), Gaps = 23/322 (7%)
Query: 393 SLNPSLPTP-QPVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIR 450
S S PTP +P + T+ GH V ++ FS + + S++AD IKIW + +
Sbjct: 22 SATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEK 81
Query: 451 TMTC-EYALCSFFVPGDRQVVIGTKTGK-LQLYDLASGNLLETIDAHDGALWSMSLSPDQ 508
T++ + + D +++ K L+++D++SG L+T+ H ++ + +P
Sbjct: 82 TISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQS 141
Query: 509 RGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDED-VLCVSYSPNQKLLAVS 567
V+G D+SV+ WD + + K +TL D V V ++ + L+ S
Sbjct: 142 NLIVSGSFDESVRIWDVK------------TGKCLKTLPAHSDPVSAVHFNRDGSLIVSS 189
Query: 568 LLDCTVKIFYVDTLKFFLSLY-GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCH 626
D +I+ + + +L PV + S +G I + D +K+W G C
Sbjct: 190 SYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCL 249
Query: 627 KSLFAHDDS--VMYLQFVPKSHLFFTAG-KDHKIKQWDADKFEHIQTLEGHHQEIWCLAV 683
K+ H + ++ F + +G +D+ + W+ E +Q L+GH + A
Sbjct: 250 KTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTAC 309
Query: 684 SPSGDYVVSSS--HDKSLRLWE 703
P+ + + S++ +DK+++LW+
Sbjct: 310 HPTENIIASAALENDKTIKLWK 331
Score = 84.7 bits (208), Expect = 4e-16
Identities = 54/186 (29%), Positives = 87/186 (46%), Gaps = 3/186 (1%)
Query: 61 LQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGG 120
L G + V+ + SP+G LA D I+I+ G+ T +GHK I+ + +
Sbjct: 41 LAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN 100
Query: 121 RLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDT 180
L S S D + +WDV + L LKGH + + F + NL+V+ D V+ WD+ T
Sbjct: 101 LLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKT 160
Query: 181 QHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIA---YLQEIEDPEEPDPKKI 237
C KT+ H V + + +++ + D R+WD A L+ + D + P +
Sbjct: 161 GKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFV 220
Query: 238 KGSSPG 243
K S G
Sbjct: 221 KFSPNG 226
Score = 74.7 bits (182), Expect = 4e-13
Identities = 36/119 (30%), Positives = 62/119 (52%)
Query: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREK 161
T GH A++++K+ G LAS S D I +W + + GHK I+ + +
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDS 99
Query: 162 NLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
NLLV++ D +K WD+ + C KT+ GH V+ + +++G+ D +R+WD+
Sbjct: 100 NLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDV 158
Score = 74.3 bits (181), Expect = 5e-13
Identities = 47/186 (25%), Positives = 86/186 (46%), Gaps = 2/186 (1%)
Query: 36 GRYVAVPACEHVF-IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSL 94
G ++A + + + IW G+ + G K ++ + S D L +D +++I+ +
Sbjct: 57 GEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSASDDKTLKIWDV 116
Query: 95 LSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQ 154
SG+ T GH + ++ + SGS D + +WDV L L H D ++
Sbjct: 117 SSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSA 176
Query: 155 ALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGAS-DS 213
F R+ +L+V+S D + + WD + C KT++ V S + I A+ D+
Sbjct: 177 VHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDN 236
Query: 214 ELRVWD 219
L++WD
Sbjct: 237 TLKLWD 242
Score = 64.3 bits (155), Expect = 5e-10
Identities = 40/176 (22%), Positives = 80/176 (45%), Gaps = 4/176 (2%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
IWD+ G+ + L+G V C +P + G D S+RI+ + +G+ T H
Sbjct: 113 IWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD 172
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRL-KGHKDAITQALFLREKNLLVTS 167
++ + +++ G + S S D +WD + L L ++ F ++ +
Sbjct: 173 PVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAA 232
Query: 168 GKDTMVKWWDLDTQHCFKTMVGHRTE---VWGLVLLSEEKRLITGASDSELRVWDI 220
D +K WD C KT GH+ E ++ ++ K +++G+ D+ + +W++
Sbjct: 233 TLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNL 288
Score = 51.6 bits (122), Expect = 3e-06
Identities = 44/196 (22%), Positives = 87/196 (44%), Gaps = 10/196 (5%)
Query: 385 QNNLVELYSLNPSLPTPQPVRTSRI--TIGGHRSDVRTLSFSSDNIAVLSAAADSI-KIW 441
Q+NL+ S + S+ V+T + T+ H V + F+ D ++S++ D + +IW
Sbjct: 140 QSNLIVSGSFDESVRI-WDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Query: 442 NRSTLQCIRTMTCE-YALCSF--FVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGA 498
+ ++ QC++T+ + SF F P + ++ T L+L+D + G L+T H
Sbjct: 199 DTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNE 258
Query: 499 LWSMSLSPDQRG---FVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCV 555
+ + + G V+G D V W+ + + Q V + E+++
Sbjct: 259 KYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIAS 318
Query: 556 SYSPNQKLLAVSLLDC 571
+ N K + + DC
Sbjct: 319 AALENDKTIKLWKSDC 334
Score = 50.1 bits (118), Expect = 1e-05
Identities = 40/180 (22%), Positives = 76/180 (42%), Gaps = 6/180 (3%)
Query: 45 EHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTF- 103
E V IWD++ G+ + L V+ + + DG + DG RI+ SG+ T
Sbjct: 151 ESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLI 210
Query: 104 NGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKD---AITQALFLRE 160
+ ++ +K+ G + + + D + +WD L GHK+ I +
Sbjct: 211 DDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHKNEKYCIFANFSVTG 270
Query: 161 KNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGA--SDSELRVW 218
+V+ +D +V W+L T+ + + GH V E + + A +D +++W
Sbjct: 271 GKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALENDKTIKLW 330
Score = 48.5 bits (114), Expect = 3e-05
Identities = 30/137 (21%), Positives = 66/137 (48%), Gaps = 6/137 (4%)
Query: 49 IWDLRKGEKI-LILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHK 107
IWD G+ + ++ V+ + SP+G ++ D +++++ G+ T+ GHK
Sbjct: 197 IWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTGHK 256
Query: 108 AAITTL--KYDQLGGR-LASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLL 164
+ + GG+ + SGS+D + +W++ + + +L+GH D + +N++
Sbjct: 257 NEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316
Query: 165 VTSG--KDTMVKWWDLD 179
++ D +K W D
Sbjct: 317 ASAALENDKTIKLWKSD 333
Score = 44.7 bits (104), Expect = 4e-04
Identities = 20/79 (25%), Positives = 38/79 (48%)
Query: 143 YRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSE 202
+ L GH A++ F L +S D ++K W KT+ GH+ + + S+
Sbjct: 39 FTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSD 98
Query: 203 EKRLITGASDSELRVWDIA 221
L++ + D L++WD++
Sbjct: 99 SNLLVSASDDKTLKIWDVS 117
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 89.4 bits (220), Expect = 1e-17
Identities = 63/207 (30%), Positives = 93/207 (44%), Gaps = 11/207 (5%)
Query: 495 HDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLC 554
H A+ ++ SP +G DK+V+ W VK E ST R R++ D
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGE-STVFRAHTATVRSVHFCSD--- 76
Query: 555 VSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRN 614
Q + S D TVK++ KF SL H V C S DG LI + S D+
Sbjct: 77 -----GQSFVTASD-DKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKT 130
Query: 615 VKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGH 674
VK+W +C S H V Y+ F P AG D+ +K WD +Q + H
Sbjct: 131 VKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLH 190
Query: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRL 701
+ L+ PSG+Y++++S D +L++
Sbjct: 191 SAAVNGLSFHPSGNYLITASSDSTLKI 217
Score = 75.9 bits (185), Expect = 2e-13
Identities = 59/245 (24%), Positives = 98/245 (40%), Gaps = 11/245 (4%)
Query: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518
C F P + G++ ++++ AH + S+ D + FVT DK
Sbjct: 28 CVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDK 87
Query: 519 SVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV 578
+VK W K S + ++ V C +SP+ +L+ + D TVK++
Sbjct: 88 TVKVWATHRQKFLFSLSQHINW-----------VRCAKFSPDGRLIVSASDDKTVKLWDK 136
Query: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
+ + S H V +D G IA D VK+W + + H +V
Sbjct: 137 SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNG 196
Query: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698
L F P + TA D +K D + + TL GH +A S +G+Y S D+
Sbjct: 197 LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQ 256
Query: 699 LRLWE 703
+ +W+
Sbjct: 257 VMVWK 261
Score = 73.9 bits (180), Expect = 6e-13
Identities = 38/117 (32%), Positives = 61/117 (52%)
Query: 589 GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLF 648
GHK V C++ S G L+A+GS D+ V+IW + AH +V + F F
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSF 80
Query: 649 FTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERT 705
TA D +K W + + + +L H + C SP G +VS+S DK+++LW+++
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 137
Score = 71.2 bits (173), Expect = 4e-12
Identities = 50/212 (23%), Positives = 94/212 (44%), Gaps = 14/212 (6%)
Query: 414 HRSDVRTLSFSSDNIAVLSAAAD-SIKIW--NRSTLQCIRTMTCEYALCSFFVPGDRQVV 470
H + VR++ F SD + ++A+ D ++K+W +R + + C+ F P R +V
Sbjct: 64 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIV 123
Query: 471 IGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKD 530
+ ++L+D +S + + H G + + P G D +VK WD
Sbjct: 124 SASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVR---- 179
Query: 531 ENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGH 590
T + L Q + ++ +S+ P+ L + D T+KI + + +L+GH
Sbjct: 180 ---THRLLQHYQLHSAAVNG----LSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH 232
Query: 591 KLPVICMDISHDGALIATGSADRNVKIWGLDF 622
+ P + S G A+G +D V +W +F
Sbjct: 233 QGPATTVAFSRTGEYFASGGSDEQVMVWKSNF 264
Score = 70.5 bits (171), Expect = 7e-12
Identities = 45/175 (25%), Positives = 78/175 (44%), Gaps = 2/175 (1%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIF-SLLSGEGNVTFNG 105
+ +W ++ + G K VTC+ SP G LA G D ++RI+ + GE V F
Sbjct: 5 LMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTV-FRA 63
Query: 106 HKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLV 165
H A + ++ + G + S D + VW + L+ L H + + A F + L+V
Sbjct: 64 HTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIV 123
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
++ D VK WD ++ C + H V + + D+ ++VWD+
Sbjct: 124 SASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 178
Score = 58.9 bits (141), Expect = 2e-08
Identities = 46/199 (23%), Positives = 81/199 (40%), Gaps = 2/199 (1%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V +W + + + L V C SPDG + +D +++++ S E ++ H
Sbjct: 89 VKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEH 148
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVT 166
+T + + G +A+ D + VWDV L + H A+ F N L+T
Sbjct: 149 GGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLIT 208
Query: 167 SGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW--DIAYLQ 224
+ D+ +K DL T+ GH+ + + +G SD ++ VW + +
Sbjct: 209 ASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWKSNFDIVD 268
Query: 225 EIEDPEEPDPKKIKGSSPG 243
E + P P SS G
Sbjct: 269 HGEVTKVPRPPATLASSMG 287
Score = 55.1 bits (131), Expect = 3e-07
Identities = 56/257 (21%), Positives = 98/257 (38%), Gaps = 20/257 (7%)
Query: 413 GHRSDVRTLSFSSDNIAVLSAAAD-SIKIW-----NRSTLQCIRTMTCEYALCSFFVPGD 466
GH+ V ++FS + S + D +++IW ST+ T T F
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSV---HFCSDG 77
Query: 467 RQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFE 526
+ V + ++++ L ++ H + SPD R V+ DK+VK WD
Sbjct: 78 QSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKS 137
Query: 527 LVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLS 586
+ +S + V V + P+ +A + +D TVK++ V T +
Sbjct: 138 SRECVHSYCEHGGF-----------VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH 186
Query: 587 LYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSH 646
H V + G + T S+D +KI L G +L H + F
Sbjct: 187 YQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGE 246
Query: 647 LFFTAGKDHKIKQWDAD 663
F + G D ++ W ++
Sbjct: 247 YFASGGSDEQVMVWKSN 263
Score = 49.3 bits (116), Expect = 2e-05
Identities = 25/91 (27%), Positives = 44/91 (48%)
Query: 128 DTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTM 187
D+ ++VW + +S YR GHKDA+T F +LL + +D V+ W + +
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVF 61
Query: 188 VGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
H V + S+ + +T + D ++VW
Sbjct: 62 RAHTATVRSVHFCSDGQSFVTASDDKTVKVW 92
Score = 37.7 bits (86), Expect = 0.051
Identities = 17/79 (21%), Positives = 34/79 (43%)
Query: 632 HDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVV 691
H D+V + F P HL + +D ++ W + H + + G V
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFV 81
Query: 692 SSSHDKSLRLWERTREPLI 710
++S DK++++W R+ +
Sbjct: 82 TASDDKTVKVWATHRQKFL 100
Score = 35.4 bits (80), Expect = 0.25
Identities = 15/49 (30%), Positives = 22/49 (44%)
Query: 654 DHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLW 702
D + W GH + C+ SPSG + S S DK++R+W
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW 50
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 87.8 bits (216), Expect = 4e-17
Identities = 83/331 (25%), Positives = 149/331 (45%), Gaps = 34/331 (10%)
Query: 411 IGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMT----CEYALCSFFVPG 465
+ GH V T F D+ +LS + D ++K+W+ +R CS + G
Sbjct: 98 LSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECS--ITG 155
Query: 466 DRQVVIGTKTGK-LQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTG-GADKSVKFW 523
D VI K ++ +DL +G LL + +D + S SPD + V+G D +
Sbjct: 156 DSSRVIAASYDKTVRAWDLETGKLLWKV-RYDTFIVSCKFSPDGKYVVSGFDVDHGICIM 214
Query: 524 DFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKF 583
D E + +T + TR++ C +Q++ +VSL C +KI+ V +
Sbjct: 215 DAENI----TTVSVIKDHHTRSI-----TSCCFDPDSQRVASVSLDRC-IKIWDVTSQAT 264
Query: 584 FLSLY-GHKLPVICMDISHDGALIATGSADRNVKIWGLDFGD------CHKSLFAHDDSV 636
L++ H + + G + T S D+N+KIW + G+ C + H+ SV
Sbjct: 265 LLTITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGACVTLMQGHEGSV 324
Query: 637 MYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHD 696
F S + G D + WD + +L+GH+ + +A+S + +++S+S D
Sbjct: 325 SSCHFARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKD 384
Query: 697 KSLRLWERTREPLILEEEREMEREAEYEESV 727
+++RLW +EE E+ +Y+++V
Sbjct: 385 RTMRLWN-------IEEIDEIPLVIKYKKAV 408
Score = 64.3 bits (155), Expect = 5e-10
Identities = 41/170 (24%), Positives = 83/170 (48%), Gaps = 11/170 (6%)
Query: 66 QEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFN-GHKAAITTLKYDQLGGRLAS 124
+ +T C PD +A D I+I+ + S +T H AI+ + G L +
Sbjct: 231 RSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLLTITKAHSNAISNCCFTFSGHFLCT 290
Query: 125 GSKDTDIIVWDVINESGLYR--------LKGHKDAITQALFLREKNLLVTSGKDTMVKWW 176
S D ++ +W+V +G +R ++GH+ +++ F R+ + L++ G D V W
Sbjct: 291 SSWDKNLKIWNV--HTGEFRNCGACVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIW 348
Query: 177 DLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEI 226
D+ + ++ GH V + + + +K +++ + D +R+W+I + EI
Sbjct: 349 DVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMRLWNIEEIDEI 398
Score = 35.8 bits (81), Expect = 0.19
Identities = 19/78 (24%), Positives = 40/78 (51%), Gaps = 1/78 (1%)
Query: 104 NGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGH-KDAITQALFLREKN 162
+GH+ A++T + +L SGS D + +WD ++ S + + K + + + +
Sbjct: 99 SGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVECSITGDSS 158
Query: 163 LLVTSGKDTMVKWWDLDT 180
++ + D V+ WDL+T
Sbjct: 159 RVIAASYDKTVRAWDLET 176
Score = 31.6 bits (70), Expect = 3.6
Identities = 23/99 (23%), Positives = 42/99 (42%), Gaps = 16/99 (16%)
Query: 132 IVW---DVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWD-------LDTQ 181
++W D +++ L GH+ A++ F + L++ D VK WD D +
Sbjct: 82 LIWGDQDPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFE 141
Query: 182 HCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
H K V + + + R+I + D +R WD+
Sbjct: 142 HRPKAPVVECS------ITGDSSRVIAASYDKTVRAWDL 174
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 87.4 bits (215), Expect = 6e-17
Identities = 40/118 (33%), Positives = 67/118 (56%)
Query: 586 SLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKS 645
+L GH+ PV + +++ + S D +K+W + GD ++L H DSV + F
Sbjct: 103 ALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSG 162
Query: 646 HLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
L + D IK WD FE I+T+ GH + +A+ P+GD++VS+S DK++++WE
Sbjct: 163 KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Score = 84.7 bits (208), Expect = 4e-16
Identities = 79/330 (23%), Positives = 139/330 (42%), Gaps = 46/330 (13%)
Query: 403 PVRTSRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRTM---TCEYAL 458
P + + GHRS V + F ++SA+ D+ IK+W+ T RT+ T
Sbjct: 96 PRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQD 155
Query: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518
SF G + + + ++L+D + T+ HD + S+++ P+ V+ DK
Sbjct: 156 ISFDHSG-KLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDK 214
Query: 519 SVKFWDFEL---VKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQK--LLAVSLLDCTV 573
++K W+ + VK T R V+ R PNQ L+A D TV
Sbjct: 215 TIKMWEVQTGYCVK--TFTGHREWVRMVR--------------PNQDGTLIASCSNDQTV 258
Query: 574 KIFYVDTLKFFLSLYGHKLPVICMDISHD--------------------GALIATGSADR 613
+++ V T + L H+ V C+ + + G + +GS D+
Sbjct: 259 RVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDK 318
Query: 614 NVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEG 673
+K+W + G C +L HD+ V + F + D ++ WD ++TL
Sbjct: 319 TIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNA 378
Query: 674 HHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
H + L + YVV+ S D+++++WE
Sbjct: 379 HEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 80.9 bits (198), Expect = 5e-15
Identities = 53/220 (24%), Positives = 100/220 (45%), Gaps = 11/220 (5%)
Query: 555 VSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRN 614
V + P ++ + D T+K++ +T F +L GH V + H G L+A+ SAD
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMT 173
Query: 615 VKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGH 674
+K+W +C +++ HD +V + +P +A +D IK W+ ++T GH
Sbjct: 174 IKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGH 233
Query: 675 HQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEEREMEREAEYEESVAKEDQPA 734
+ + + + G + S S+D+++R+W + +E + E E V + A
Sbjct: 234 REWVRMVRPNQDGTLIASCSNDQTVRVW--------VVATKECKAELREHEHVVECISWA 285
Query: 735 VPGETQGDSYFTGKKTIETVKAAERIMEAIELYREETAKM 774
S TG +T ++ K ++ R++T KM
Sbjct: 286 PESSYSSISEATGSETKKSGKPGPFLLSG---SRDKTIKM 322
Score = 80.1 bits (196), Expect = 9e-15
Identities = 50/191 (26%), Positives = 87/191 (45%), Gaps = 20/191 (10%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+WD + E I + G V+ + P+G H+ D +I+++ + +G TF GH+
Sbjct: 176 LWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHRE 235
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN------ 162
+ ++ +Q G +AS S D + VW V + L+ H+ + + E +
Sbjct: 236 WVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISE 295
Query: 163 --------------LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLIT 208
L++ +D +K WD+ T C T+VGH V G++ S K +++
Sbjct: 296 ATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILS 355
Query: 209 GASDSELRVWD 219
A D LRVWD
Sbjct: 356 CADDKTLRVWD 366
Score = 76.3 bits (186), Expect = 1e-13
Identities = 49/173 (28%), Positives = 83/173 (47%), Gaps = 3/173 (1%)
Query: 50 WDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAA 109
W R EK L G + VT + P + ED +I+++ +G+ T GH +
Sbjct: 94 WIPRPPEKYA-LSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDS 152
Query: 110 ITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGK 169
+ + +D G LAS S D I +WD + + GH ++ + + +V++ +
Sbjct: 153 VQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASR 212
Query: 170 DTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGAS-DSELRVWDIA 221
D +K W++ T +C KT GHR V +V +++ LI S D +RVW +A
Sbjct: 213 DKTIKMWEVQTGYCVKTFTGHREWV-RMVRPNQDGTLIASCSNDQTVRVWVVA 264
Score = 67.4 bits (163), Expect = 6e-11
Identities = 47/215 (21%), Positives = 88/215 (40%), Gaps = 20/215 (9%)
Query: 25 NIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGY 84
N+ V + V+ + + +W+++ G + G ++ V + P+ DG +A
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 85 EDGSIRIFSLLSGEGNVTFNGHKAAIT--------------------TLKYDQLGGRLAS 124
D ++R++ + + E H+ + T K + G L S
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 125 GSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCF 184
GS+D I +WDV L L GH + + LF +++ D ++ WD + C
Sbjct: 314 GSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCM 373
Query: 185 KTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
KT+ H V L ++TG+ D ++VW+
Sbjct: 374 KTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
Score = 49.3 bits (116), Expect = 2e-05
Identities = 41/193 (21%), Positives = 79/193 (40%), Gaps = 20/193 (10%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+WD G+ L+G V + G LA D +I+++ E T +GH
Sbjct: 134 VWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDH 193
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSG 168
++++ G + S S+D I +W+V + GH++ + ++ L+ +
Sbjct: 194 NVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCS 253
Query: 169 KDTMVKWWDLDTQHCFKTMVGHRTEV----W---------GLVLLSEEKR-------LIT 208
D V+ W + T+ C + H V W SE K+ L++
Sbjct: 254 NDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLS 313
Query: 209 GASDSELRVWDIA 221
G+ D +++WD++
Sbjct: 314 GSRDKTIKMWDVS 326
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 86.7 bits (213), Expect = 1e-16
Identities = 69/245 (28%), Positives = 103/245 (42%), Gaps = 13/245 (5%)
Query: 459 CSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADK 518
C PG++ V G+ ++++DLASG L ++ H + + +S + G DK
Sbjct: 209 CIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDK 268
Query: 519 SVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV 578
VK WD E K LS V + P +L D T +I+ V
Sbjct: 269 QVKCWDLEYNKVIRHYHGHLSA-----------VYGLDLHPTIDVLVTCSRDSTARIWDV 317
Query: 579 DTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMY 638
T +L GH V + I TGS D +++W L G +L H SV
Sbjct: 318 RTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSVRA 377
Query: 639 LQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKS 698
+ P+ H F +G IKQW IQ L GH+ I L V+ G +VS + + +
Sbjct: 378 VVLHPR-HYTFASGSPDNIKQWKFPDGSFIQNLSGHNAIINTLTVNSDG-VLVSGADNGT 435
Query: 699 LRLWE 703
+ LW+
Sbjct: 436 MHLWD 440
Score = 70.9 bits (172), Expect = 5e-12
Identities = 38/122 (31%), Positives = 62/122 (50%)
Query: 582 KFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQF 641
K + + GH V C+ + TGSADR +KIW L G SL H +V +
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
Query: 642 VPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRL 701
+S F+ G+D ++K WD + + I+ GH ++ L + P+ D +V+ S D + R+
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARI 314
Query: 702 WE 703
W+
Sbjct: 315 WD 316
Score = 68.9 bits (167), Expect = 2e-11
Identities = 38/152 (25%), Positives = 67/152 (44%)
Query: 552 VLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSA 611
V C++ P + D T+KI+ + + K LSL GH V + +S + +
Sbjct: 207 VRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGE 266
Query: 612 DRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTL 671
D+ VK W L++ + H +V L P + T +D + WD + TL
Sbjct: 267 DKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTL 326
Query: 672 EGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
GH + + + +++ SHD ++RLW+
Sbjct: 327 SGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358
Score = 63.9 bits (154), Expect = 7e-10
Identities = 49/215 (22%), Positives = 94/215 (43%), Gaps = 4/215 (1%)
Query: 15 VFGVIGSQKGNIVFVTLRGEKGRYVAVPACEHVFIWDLRKGEKILILQGLKQEVTCLCPS 74
++ VI G + + + +V A + IWDL G+ L L G V + S
Sbjct: 196 LYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVS 255
Query: 75 PDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVW 134
+L ED ++ + L + ++GH +A+ L L + S+D+ +W
Sbjct: 256 TRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIW 315
Query: 135 DVINESGLYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEV 194
DV ++ ++ L GH +A+ + ++T DT ++ WDL T+ H+ V
Sbjct: 316 DVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTLTNHKKSV 375
Query: 195 WGLVLLSEEKRLITGASDSELRVW---DIAYLQEI 226
+VL +G+ D+ ++ W D +++Q +
Sbjct: 376 RAVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNL 409
Score = 41.2 bits (95), Expect = 0.005
Identities = 42/216 (19%), Positives = 92/216 (42%), Gaps = 25/216 (11%)
Query: 336 GEEEDPEVNVEMSL-QDEIQRVTNIKTSAKIKSFDLIHSPHGELKAVFLLQNNLVELYSL 394
G + P ++V ++ +D R+ +++T A + H+ G AV ++ E +
Sbjct: 293 GLDLHPTIDVLVTCSRDSTARIWDVRTKASV------HTLSGHTNAVATVRCQAAEPQII 346
Query: 395 NPSLPTPQPV-----RTSRITIGGHRSDVRTLSFSSDNIAVLSAAADSIKIWNRSTLQCI 449
S T + +R+T+ H+ VR + + S + D+IK W I
Sbjct: 347 TGSHDTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPDNIKQWKFPDGSFI 406
Query: 450 RTMTCEYALC-SFFVPGDRQVVIGTKTGKLQLYDLASGNLLETIDA--------HDGALW 500
+ ++ A+ + V D +V G G + L+D +G + + A + ++
Sbjct: 407 QNLSGHNAIINTLTVNSDGVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIF 466
Query: 501 SMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQK 536
+ + + +T ADK++K + +D+ +T++
Sbjct: 467 ACAFDQSESRLLTAEADKTIKVYR----EDDTATEE 498
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 85.5 bits (210), Expect = 2e-16
Identities = 78/312 (25%), Positives = 128/312 (41%), Gaps = 35/312 (11%)
Query: 407 SRITIGGHRSDVRTLSFSSDNIAVLSAAADS-IKIWNRSTLQCIRT--------MTCEYA 457
+R T+ GH + + + +++D+ ++SA+ D + +W+ T + MTC YA
Sbjct: 47 TRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYA 106
Query: 458 LCSFFVPGDRQVVIGTKTGKLQLYDLAS--GNLLET--IDAHDGALWSMSLSPDQRGFVT 513
P V G +Y+L S GN+ + + AH G L S D VT
Sbjct: 107 ------PSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYL-SCCRFLDDNNIVT 159
Query: 514 GGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDEDVLCVSYSPNQKLLAVSLLDCTV 573
D + WD E QK + V T D + ++ SP+ L D +
Sbjct: 160 SSGDTTCALWDIE-----TGQQKTVFVGHTG------DCMSLAVSPDFNLFISGACDASA 208
Query: 574 KIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGLDFGDCHKSLFAHD 633
K++ V + GH+ + + +G I TGS D + +++ L D F+H+
Sbjct: 209 KLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLR-ADQELICFSHE 267
Query: 634 D---SVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPSGDYV 690
+ + F L F D WD+ K E + L GH + CL V+ G V
Sbjct: 268 SIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAV 327
Query: 691 VSSSHDKSLRLW 702
+ S D L++W
Sbjct: 328 ATGSWDSFLKIW 339
Score = 62.8 bits (151), Expect = 1e-09
Identities = 49/217 (22%), Positives = 85/217 (39%), Gaps = 16/217 (7%)
Query: 491 TIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTLQLDE 550
T+ H +++M + D + V+ D + WD ++ R S
Sbjct: 50 TLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSW---------- 99
Query: 551 DVLCVSYSPNQKLLAVSLLDCTVKIFYVDT----LKFFLSLYGHKLPVICMDISHDGALI 606
V+ +Y+P+ +A LD I+ + + +K L H + C D ++
Sbjct: 100 -VMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYLSCCRFLDDNNIV 158
Query: 607 ATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFE 666
T S D +W ++ G H M L P +LF + D K WD +
Sbjct: 159 -TSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGT 217
Query: 667 HIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
QT GH +I + P+G+ + + S D S RL++
Sbjct: 218 CRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFD 254
Score = 62.4 bits (150), Expect = 2e-09
Identities = 41/184 (22%), Positives = 75/184 (40%), Gaps = 5/184 (2%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVT---- 102
+ +WD K+ + V +P G +A G D I++L S EGNV
Sbjct: 79 LIVWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRE 138
Query: 103 FNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKN 162
+ H ++ ++ + + S DT +WD+ GH + N
Sbjct: 139 LSAHTGYLSCCRFLD-DNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFN 197
Query: 163 LLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAY 222
L ++ D K WD+ C +T GH +++ + + + TG+ D+ R++D+
Sbjct: 198 LFISGACDASAKLWDVREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRA 257
Query: 223 LQEI 226
QE+
Sbjct: 258 DQEL 261
Score = 55.8 bits (133), Expect = 2e-07
Identities = 42/174 (24%), Positives = 72/174 (41%), Gaps = 4/174 (2%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+WD+ G++ + G + L SPD G D S +++ + G TF GH++
Sbjct: 168 LWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWDVREGTCRQTFTGHES 227
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKD---AITQALFLREKNLLV 165
I + + G + +GS D ++D+ + L H+ IT F LL
Sbjct: 228 DINAICFFPNGEAICTGSDDASCRLFDLRADQELICF-SHESIICGITSVAFSLSGRLLF 286
Query: 166 TSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWD 219
D WD + GH V L + ++ + TG+ DS L++W+
Sbjct: 287 AGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFLKIWN 340
Score = 50.1 bits (118), Expect = 1e-05
Identities = 40/191 (20%), Positives = 80/191 (41%), Gaps = 14/191 (7%)
Query: 43 ACEHVFIWDLRKGEKIL---------ILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFS 93
AC V + +L G +++ L+G ++ + + D L +DG + ++
Sbjct: 24 ACADVTLAELVSGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWD 83
Query: 94 LLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR----LKGHK 149
+ + + T Y G +A G D ++++ + G + L H
Sbjct: 84 SYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHT 143
Query: 150 DAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITG 209
++ FL + N++ +SG DT WD++T VGH + L + + I+G
Sbjct: 144 GYLSCCRFLDDNNIVTSSG-DTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISG 202
Query: 210 ASDSELRVWDI 220
A D+ ++WD+
Sbjct: 203 ACDASAKLWDV 213
Score = 37.0 bits (84), Expect = 0.087
Identities = 26/124 (20%), Positives = 50/124 (40%), Gaps = 5/124 (4%)
Query: 406 TSRITIGGHRSDVRTLSFSSDNIAVLSAAAD-SIKIWNRSTLQCIRTMTCEYALCSF--- 461
T R T GH SD+ + F + A+ + + D S ++++ Q + + E +C
Sbjct: 217 TCRQTFTGHESDINAICFFPNGEAICTGSDDASCRLFDLRADQELICFSHESIICGITSV 276
Query: 462 -FVPGDRQVVIGTKTGKLQLYDLASGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSV 520
F R + G ++D + + HD + + ++ D TG D +
Sbjct: 277 AFSLSGRLLFAGYDDFNCNVWDSMKSERVGILSGHDNRVSCLGVTADGMAVATGSWDSFL 336
Query: 521 KFWD 524
K W+
Sbjct: 337 KIWN 340
Score = 30.8 bits (68), Expect = 6.2
Identities = 18/97 (18%), Positives = 38/97 (39%)
Query: 627 KSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQEIWCLAVSPS 686
++L H + + + S L +A +D K+ WD+ + + + A +PS
Sbjct: 49 RTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIPLRSSWVMTCAYAPS 108
Query: 687 GDYVVSSSHDKSLRLWERTREPLILEEEREMEREAEY 723
G++V D ++ ++ RE+ Y
Sbjct: 109 GNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGY 145
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 85.5 bits (210), Expect = 2e-16
Identities = 65/225 (28%), Positives = 106/225 (47%), Gaps = 16/225 (7%)
Query: 488 LLETIDAH-DGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTL 546
LL + AH D W ++ +P + G D+ ++ W E D + LS RT+
Sbjct: 7 LLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTE--GDSWICKSVLSEGHQRTV 64
Query: 547 QLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV--DTLKFFLSLYGHKLPVICMDISHDGA 604
+ V++SP LA + D T I+ D + +L GH+ V + + G
Sbjct: 65 RK------VAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
Query: 605 LIATGSADRNVKIWGLDFGD---CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW- 660
L+AT S D++V +W +D D C L +H V ++ + P L +A D +K +
Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
Query: 661 -DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWER 704
+ D + TLEGH +W LA PSG + S S D+++R+W +
Sbjct: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQ 223
Score = 59.7 bits (143), Expect = 1e-08
Identities = 41/122 (33%), Positives = 65/122 (53%), Gaps = 14/122 (11%)
Query: 603 GALIATGSADRNVKIWGLDFGDCH--KSLFA--HDDSVMYLQFVPKSHLFFTAGKDHKIK 658
G L+A+ DR ++IWG + GD KS+ + H +V + + P + +A D
Sbjct: 28 GTLLASCGGDRRIRIWGTE-GDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTC 86
Query: 659 QW--DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEERE 716
W + D FE + TLEGH E+ +A +PSG+ + + S DKS+ +WE ++EE E
Sbjct: 87 IWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE-------VDEEDE 139
Query: 717 ME 718
E
Sbjct: 140 YE 141
Score = 56.6 bits (135), Expect = 1e-07
Identities = 42/169 (24%), Positives = 77/169 (45%), Gaps = 7/169 (4%)
Query: 57 KILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGN--VTFNGHKAAITTLK 114
K ++ +G ++ V + SP G +LA D + I+ + T GH+ + ++
Sbjct: 53 KSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVA 112
Query: 115 YDQLGGRLASGSKDTDIIVWDVINESG---LYRLKGHKDAITQALFLREKNLLVTSGKDT 171
+ G LA+ S+D + VW+V E + L H + ++ + LL ++ D
Sbjct: 113 WAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDD 172
Query: 172 MVKWW--DLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
VK + + D C T+ GH + VW L +RL + + D +R+W
Sbjct: 173 TVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Score = 52.4 bits (124), Expect = 2e-06
Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 589 GHKLPVICMDISHDGALIATGSADRNVKIW--GLDFGDCHKSLFAHDDSVMYLQFVPKSH 646
GH+ V + S G +A+ S D IW D +C +L H++ V + + P +
Sbjct: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
Query: 647 LFFTAGKDHKIKQWDADK---FEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
L T +D + W+ D+ +E + L H Q++ + PS + + S+S+D +++L+
Sbjct: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
Query: 704 RTRE 707
+
Sbjct: 179 EEED 182
Score = 37.7 bits (86), Expect = 0.051
Identities = 29/120 (24%), Positives = 49/120 (40%), Gaps = 5/120 (4%)
Query: 113 LKYDQLGGRLASGSKDTDIIVWDVINESGLYRL---KGHKDAITQALFLREKNLLVTSGK 169
L ++ G LAS D I +W +S + + +GH+ + + + N L ++
Sbjct: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
Query: 170 DTMVKWW--DLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIE 227
D W + D C T+ GH EV + L T + D + VW++ E E
Sbjct: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
Score = 34.7 bits (78), Expect = 0.43
Identities = 22/93 (23%), Positives = 46/93 (49%), Gaps = 5/93 (5%)
Query: 47 VFIWDLRKGEK---ILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGN--V 101
V++W++ + ++ + +L Q+V + P LA D +++++ +
Sbjct: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
Query: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVW 134
T GH++ + +L +D G RLAS S D + +W
Sbjct: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 84.3 bits (207), Expect = 5e-16
Identities = 55/219 (25%), Positives = 91/219 (41%), Gaps = 11/219 (5%)
Query: 485 SGNLLETIDAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTR 544
+G ++ + H G ++S D G ++ D S+++WD S + +
Sbjct: 331 AGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDL------GSFTNTVLYQGHA 384
Query: 545 TLQLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGA 604
D D+ SP A D T +++ D GH V C+ +
Sbjct: 385 YPVWDLDI-----SPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSN 439
Query: 605 LIATGSADRNVKIWGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADK 664
+ATGS D+ V++W G+ + H V+ L F P +AG+D ++K WD
Sbjct: 440 YLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS 499
Query: 665 FEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
+ L GH I L SP + S+S D S+R+W+
Sbjct: 500 GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWD 538
Score = 77.0 bits (188), Expect = 8e-14
Identities = 40/149 (26%), Positives = 72/149 (48%)
Query: 49 IWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKA 108
+W + + I G +V C+ P+ +LA G D ++R++S G F GH+
Sbjct: 410 LWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRG 469
Query: 109 AITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSG 168
+ +L + G LAS +D + +WD+ + + L+GH D IT F + L+ ++
Sbjct: 470 PVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASAS 529
Query: 169 KDTMVKWWDLDTQHCFKTMVGHRTEVWGL 197
D V+ WD+ +C G +E+ G+
Sbjct: 530 MDNSVRVWDIRNTYCSAPADGSSSELVGV 558
Score = 76.6 bits (187), Expect = 1e-13
Identities = 45/171 (26%), Positives = 76/171 (44%)
Query: 50 WDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAA 109
WDL ++ QG V L SP L+ A G D + R++S + GH A
Sbjct: 369 WDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLAD 428
Query: 110 ITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYRLKGHKDAITQALFLREKNLLVTSGK 169
+ +K+ LA+GS D + +W + + GH+ + F L ++G+
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
Query: 170 DTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDI 220
D +K WDL + +K + GH + L + + + + D+ +RVWDI
Sbjct: 489 DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 59.3 bits (142), Expect = 2e-08
Identities = 39/137 (28%), Positives = 51/137 (37%)
Query: 85 EDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIVWDVINESGLYR 144
ED SIR + L S V + GH + L ASGS D +W L
Sbjct: 362 EDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRI 421
Query: 145 LKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHRTEVWGLVLLSEEK 204
GH + F N L T D V+ W + + GHR V L K
Sbjct: 422 YAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGK 481
Query: 205 RLITGASDSELRVWDIA 221
L + D L++WD+A
Sbjct: 482 YLASAGEDQRLKLWDLA 498
Score = 57.0 bits (136), Expect = 8e-08
Identities = 30/92 (32%), Positives = 47/92 (51%)
Query: 47 VFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGH 106
V +W ++G + + G + V L SP+G +LA ED ++++ L SG GH
Sbjct: 450 VRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGH 509
Query: 107 KAAITTLKYDQLGGRLASGSKDTDIIVWDVIN 138
IT+L + G +AS S D + VWD+ N
Sbjct: 510 TDNITSLTFSPDSGLIASASMDNSVRVWDIRN 541
Score = 55.8 bits (133), Expect = 2e-07
Identities = 42/149 (28%), Positives = 65/149 (43%), Gaps = 10/149 (6%)
Query: 558 SPNQKLLAVSLLDCTVKIFYVDTLKFFLSLYGHKLPVICMDISHDGALIATGSADRNVKI 617
SP+ KLLA + +K++ + + K L H++ V + ++ D L D N
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKK--LKSEPHQVDVSRIHLACD-ILEEEDDEDDNA-- 331
Query: 618 WGLDFGDCHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQWDADKFEHIQTLEGHHQE 677
G K L H V +F+ S + +D I+ WD F + +GH
Sbjct: 332 -----GTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYP 386
Query: 678 IWCLAVSPSGDYVVSSSHDKSLRLWERTR 706
+W L +SP Y S SHD++ RLW R
Sbjct: 387 VWDLDISPYSLYFASGSHDRTARLWSFDR 415
Score = 53.5 bits (127), Expect = 9e-07
Identities = 57/279 (20%), Positives = 109/279 (39%), Gaps = 47/279 (16%)
Query: 373 SPHGELKAVFLLQNNLVELYSLNPSLPTPQPVRTSRITIGGHRSDVRTLSFSSDNIAVLS 432
SP +L A N+ ++L+SL R+ ++ H+ DV + + D +
Sbjct: 277 SPDSKLLAAGF-DNSCIKLWSL----------RSKKLKSEPHQVDVSRIHLACDILEEED 325
Query: 433 AAADSIKIWNRSTLQCIRTMTCEYALCSFFVPGDRQVVIGTKTGKLQLYDLASGNLLETI 492
D N T I C + F+ ++ ++ ++ +DL S
Sbjct: 326 DEDD-----NAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLY 380
Query: 493 DAHDGALWSMSLSPDQRGFVTGGADKSVKFWDFE-------------------------- 526
H +W + +SP F +G D++ + W F+
Sbjct: 381 QGHAYPVWDLDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNY 440
Query: 527 -LVKDENSTQKRLSVKQTRTLQLDED----VLCVSYSPNQKLLAVSLLDCTVKIFYVDTL 581
+ T + S +Q +++L VL +++SPN K LA + D +K++ + +
Sbjct: 441 LATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASG 500
Query: 582 KFFLSLYGHKLPVICMDISHDGALIATGSADRNVKIWGL 620
+ L GH + + S D LIA+ S D +V++W +
Sbjct: 501 TLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Score = 47.0 bits (110), Expect = 8e-05
Identities = 53/244 (21%), Positives = 99/244 (40%), Gaps = 28/244 (11%)
Query: 74 SPDGLHLAVGYEDGSIRIFSLLSGEGNVTFNGHKAAITTLKYDQLGGRLASGSKDTDIIV 133
SPD LA G+++ I+++SL S + + H+ ++ + L + D D
Sbjct: 277 SPDSKLLAAGFDNSCIKLWSLRSKK--LKSEPHQVDVSRI---HLACDILEEEDDED--- 328
Query: 134 WDVINESG--LYRLKGHKDAITQALFLREKNLLVTSGKDTMVKWWDLDTQHCFKTMVGHR 191
+ +G + L+GH + FL + + L++ +D +++WDL + GH
Sbjct: 329 ----DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHA 384
Query: 192 TEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIEDPEEPDPKKIKGSSPGIQDTLEAE 251
VW L + +G+ D R+W + P +I D ++
Sbjct: 385 YPVWDLDISPYSLYFASGSHDRTARLWSF---------DRTYPLRIYAGHLADVDCVKFH 435
Query: 252 DGAFETDEAPED---RILSCRKAGSI--MREGRDRVVNLAVDKTGRILACHGTDSVLELF 306
+ D R+ S ++ S+ R V++LA G+ LA G D L+L+
Sbjct: 436 PNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLW 495
Query: 307 CILS 310
+ S
Sbjct: 496 DLAS 499
Score = 31.2 bits (69), Expect = 4.8
Identities = 21/89 (23%), Positives = 41/89 (46%), Gaps = 1/89 (1%)
Query: 36 GRYVAVPA-CEHVFIWDLRKGEKILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSL 94
G+Y+A + + +WDL G L+G +T L SPD +A D S+R++ +
Sbjct: 480 GKYLASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDI 539
Query: 95 LSGEGNVTFNGHKAAITTLKYDQLGGRLA 123
+ + +G + + + Q+ L+
Sbjct: 540 RNTYCSAPADGSSSELVGVYTGQMSNVLS 568
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 35,113,712
Number of Sequences: 37866
Number of extensions: 1600519
Number of successful extensions: 11771
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 231
Number of HSP's successfully gapped in prelim test: 129
Number of HSP's that attempted gapping in prelim test: 6695
Number of HSP's gapped (non-prelim): 2978
length of query: 943
length of database: 18,247,518
effective HSP length: 112
effective length of query: 831
effective length of database: 14,006,526
effective search space: 11639423106
effective search space used: 11639423106
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.