Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 5729858
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
(1464 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5729858 nuclear receptor coactivator 2 [Homo sapiens] 2945 0.0
gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens] 1012 0.0
gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens] 1009 0.0
gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens] 587 e-167
gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens] 587 e-167
gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens] 587 e-167
gi|4758010 clock [Homo sapiens] 90 2e-17
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ... 84 1e-15
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ... 77 9e-14
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ... 77 9e-14
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ... 77 9e-14
gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2 ... 75 4e-13
gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1 [... 75 4e-13
gi|21614542 single-minded homolog 1 [Homo sapiens] 75 4e-13
gi|22027471 neuronal PAS domain protein 2 [Homo sapiens] 75 6e-13
gi|40254439 endothelial PAS domain protein 1 [Homo sapiens] 72 3e-12
gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c ... 69 3e-11
gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a ... 69 3e-11
gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens] 68 6e-11
gi|4827004 single-minded homolog 2 long isoform [Homo sapiens] 68 6e-11
gi|194239684 single-minded homolog 2 short isoform [Homo sapiens] 68 6e-11
gi|4502003 aryl hydrocarbon receptor [Homo sapiens] 68 7e-11
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ... 64 8e-10
gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens] 64 1e-09
gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b ... 64 1e-09
gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Ho... 61 7e-09
gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens] 60 2e-08
gi|22027482 neuronal PAS domain protein 1 [Homo sapiens] 59 3e-08
gi|30795242 aryl hydrocarbon receptor nuclear translocator isofo... 57 2e-07
gi|30795240 aryl hydrocarbon receptor nuclear translocator isofo... 56 2e-07
>gi|5729858 nuclear receptor coactivator 2 [Homo sapiens]
Length = 1464
Score = 2945 bits (7634), Expect = 0.0
Identities = 1464/1464 (100%), Positives = 1464/1464 (100%)
Query: 1 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI 60
MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI
Sbjct: 1 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI 60
Query: 61 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML 120
DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML
Sbjct: 61 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML 120
Query: 121 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI 180
EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI
Sbjct: 121 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI 180
Query: 181 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE 240
VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE
Sbjct: 181 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE 240
Query: 241 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV 300
EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV
Sbjct: 241 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV 300
Query: 301 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT 360
RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT
Sbjct: 301 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT 360
Query: 361 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS 420
TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS
Sbjct: 361 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS 420
Query: 421 SNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPG 480
SNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPG
Sbjct: 421 SNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQSSPGMNPG 480
Query: 481 QPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQAL 540
QPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQAL
Sbjct: 481 QPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNALQAL 540
Query: 541 SEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQA 600
SEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQA
Sbjct: 541 SEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGEPSEGTTGQA 600
Query: 601 ESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASS 660
ESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASS
Sbjct: 601 ESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSDQMEPSPLASS 660
Query: 661 LSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESS 720
LSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESS
Sbjct: 661 LSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSPVDLAKLTAEATGKDLSQESS 720
Query: 721 STAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTK 780
STAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTK
Sbjct: 721 STAPGSEVTIKQEPVSPKKKENALLRYLLDKDDTKDIGLPEITPKLERLDSKTDPASNTK 780
Query: 781 LIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAII 840
LIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAII
Sbjct: 781 LIAMKTEKEEMSFEPGDQPGSELDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAII 840
Query: 841 NDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAG 900
NDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAG
Sbjct: 841 NDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQLGRLLPNQNLPLDITLQSPTGAG 900
Query: 901 PFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSA 960
PFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSA
Sbjct: 901 PFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSA 960
Query: 961 VRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGG 1020
VRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGG
Sbjct: 961 VRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGG 1020
Query: 1021 PQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALL 1080
PQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALL
Sbjct: 1021 PQYSQQQAPPNQTAPWPESILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALL 1080
Query: 1081 DQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQ 1140
DQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQ
Sbjct: 1081 DQLYLALRNFDGLEEIDRALGIPELVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQ 1140
Query: 1141 AQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQ 1200
AQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQ
Sbjct: 1141 AQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQ 1200
Query: 1201 QNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQ 1260
QNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQ
Sbjct: 1201 QNRQPLMNQISNVSNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQ 1260
Query: 1261 RTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATT 1320
RTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATT
Sbjct: 1261 RTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATT 1320
Query: 1321 PQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQAN 1380
PQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQAN
Sbjct: 1321 PQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQAN 1380
Query: 1381 TSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGG 1440
TSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGG
Sbjct: 1381 TSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGG 1440
Query: 1441 NLFPNQLPGMDMIKQEGDTTRKYC 1464
NLFPNQLPGMDMIKQEGDTTRKYC
Sbjct: 1441 NLFPNQLPGMDMIKQEGDTTRKYC 1464
>gi|32307124 nuclear receptor coactivator 3 isoform b [Homo sapiens]
Length = 1420
Score = 1012 bits (2617), Expect = 0.0
Identities = 643/1508 (42%), Positives = 884/1508 (58%), Gaps = 168/1508 (11%)
Query: 1 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI 60
MSG+GEN DP +++RKRK D G + EKR REQE+KYIEELAELI AN +DI
Sbjct: 1 MSGLGENL-DPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDI 59
Query: 61 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML 120
DNFN KPDKCAILKETV+QIRQIKEQ K + N D+VQK+DVSSTGQGVIDKD+LGP++L
Sbjct: 60 DNFNVKPDKCAILKETVRQIRQIKEQGKTIS-NDDDVQKADVSSTGQGVIDKDSLGPLLL 118
Query: 121 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI 180
+ALDGF FVVN +GN+VFVSENVTQYL+Y QE+L+N SVY+ILH D +F+KNL PKS
Sbjct: 119 QALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL-PKST 177
Query: 181 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE 240
VNG SW+ E R+ SHTFNCRML+K D E+ + + E Q+YETMQCFA+SQP+++ E
Sbjct: 178 VNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMME 237
Query: 241 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV 300
EGEDLQSC+ICVARR+ ER + ESF TR DL GK+ ++DT+++R++M+PG+ED++
Sbjct: 238 EGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDII 297
Query: 301 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT 360
RRCIQ+F + ++G+S S KRH+ E G A + +YRFSL+DGT+V AQTKSKL R+
Sbjct: 298 RRCIQRFFSLNDGQSWS-QKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPV 356
Query: 361 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS 420
TN+ +S H L REQN NP+ GQ + P+ +S+ S +P Q + +
Sbjct: 357 TNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGG----MSMSPNQGLQMP 412
Query: 421 SNINFPINGPKEQMGMPMGRFGGSGGMNHVS---GMQA-TTPQGSNYALKMNSPSQSSPG 476
S+ + + P M R+GGS + ++ GMQ+ ++ Q +NY L M+SP SPG
Sbjct: 413 SSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPG 472
Query: 477 MNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNA 536
+ P Q M+SPR+R GSP+I QFSP +HSP+ +TGN HS+++SSL+A
Sbjct: 473 LAPNQQNIMISPRNR------GSPKIASHQFSPVAGVHSPMASSGNTGN-HSFSSSSLSA 525
Query: 537 LQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGE--PSE 594
LQA+SEG G SL S+L+SP K L NSP NMN SK+ + DSK G Y + P E
Sbjct: 526 LQAISEGVGTSLLSTLSSPGPK---LDNSP-NMNITQPSKVSNQDSKSPLGFYCDQNPVE 581
Query: 595 GTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSD---- 650
+ Q+ S H +++ S E A+ Q +SKG KLLQLLT SD
Sbjct: 582 SSMCQSNSRDHLSDKESKES-------SVEGAENQRGPLESKGHKKLLQLLTCSSDDRGH 634
Query: 651 -QMEPSPLASSL----------SDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSS 699
+ SPL SS S + ++G + + + HG+ L+EKH+ILH+LLQ+ +S
Sbjct: 635 SSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNS 694
Query: 700 PVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKE-NALLRYLLDKDDTKDIG 758
P ++AK+TAEATGKD SS T+ G +KQE +SPKKKE NALLRYLLD+DD D
Sbjct: 695 PAEVAKITAEATGKD---TSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDAL 751
Query: 759 LPEITPKLERLDSKTDPASNTKLIAMKTEKE-EMSFEPGDQPGSELDNLEEILDDLQNSQ 817
E+ P++E +D+K +++ + + EK+ ++ E ++ +LDNL+ IL DL +S
Sbjct: 752 SKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSD 811
Query: 818 LPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQ 877
+ G+ G+ KQ + G L+ SQS
Sbjct: 812 FYNNSISSN-GSHLGT--KQQVFQ---------------GTNSLGLKSSQS--------- 844
Query: 878 LGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIP-QPGMMGNQGMIGNQGNLGNSS 936
+ + P N ++L SP G PP++N S + ++P QP + GN M+ +Q N G+S
Sbjct: 845 VQSIRPPYNRA--VSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSM 902
Query: 937 TGMIGNSASRPTMPSGEWA-PQSSAVRVTCAATTS----------AMNRPVQGGMIRNPA 985
G N T SG+W P S A R+ + S ++ RP GG I
Sbjct: 903 GGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSI---- 958
Query: 986 ASIPMRPSSQPGQRQTL--QSQVMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPI 1043
++P+R +S PG R L Q Q++ + P E+ M MG Y Q A NQ WP+ +L +
Sbjct: 959 PTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYG-QAAASNQLGSWPDGMLSM 1017
Query: 1044 DQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFD--GLEEIDRALG 1101
+Q S +QNR +S DDL+ P E SDE ALLDQL+ L N D GLEEIDRALG
Sbjct: 1018 EQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALG 1077
Query: 1102 IPELVSQSQAVDPEQ--FSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTM 1159
IPELV+Q QA++P+Q F Q++ +M++QKA ++ Q Y +Q QG FH
Sbjct: 1078 IPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQG--------GFHLQ 1129
Query: 1160 GQRPSYATLRMQ-------PRPGLRPTGLVQ----NQPNQLRLQLQHRLQAQ----QNRQ 1204
GQ PS+ ++ Q P G+ P + N P QLR+QLQ RLQ Q Q+RQ
Sbjct: 1130 GQSPSFNSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQ 1189
Query: 1205 PLMNQISN-VSNVNLTLRPGV-PTQAPINAQMLAQRQREILNQHLR-------------- 1248
L ++ N + +RP + P Q +NAQM+AQR RE+L+ H R
Sbjct: 1190 ALELKMENPTAGGAAVMRPMMQPQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQQQQQ 1249
Query: 1249 -----QRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPP 1303
Q+Q QQQQ QQ+ + Q + P++ A M ++ P +PQA QQFP+ P
Sbjct: 1250 QQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQFPYQP 1309
Query: 1304 NYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQGNMGG 1363
NYG+ QQPDP F ++P + +MS RM +Q+PMMQ QA YQ+ S++ GW GN+
Sbjct: 1310 NYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQS-SEMKGWPSGNLAR 1368
Query: 1364 NSMFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSVPTSG 1423
NS FSQQ F Q N ++YS M MN +G + ++ +P SG
Sbjct: 1369 NSSFSQQ---QFAHQGNPAVYS---------------MVHMNGSSGHMGQMNMNPMPMSG 1410
Query: 1424 LSSMGPEQ 1431
+ MGP+Q
Sbjct: 1411 M-PMGPDQ 1417
>gi|32307126 nuclear receptor coactivator 3 isoform a [Homo sapiens]
Length = 1424
Score = 1009 bits (2608), Expect = 0.0
Identities = 642/1512 (42%), Positives = 883/1512 (58%), Gaps = 172/1512 (11%)
Query: 1 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI 60
MSG+GEN DP +++RKRK D G + EKR REQE+KYIEELAELI AN +DI
Sbjct: 1 MSGLGENL-DPLASDSRKRKLPCDTPGQGLTCSGEKRRREQESKYIEELAELISANLSDI 59
Query: 61 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML 120
DNFN KPDKCAILKETV+QIRQIKEQ K + N D+VQK+DVSSTGQGVIDKD+LGP++L
Sbjct: 60 DNFNVKPDKCAILKETVRQIRQIKEQGKTIS-NDDDVQKADVSSTGQGVIDKDSLGPLLL 118
Query: 121 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI 180
+ALDGF FVVN +GN+VFVSENVTQYL+Y QE+L+N SVY+ILH D +F+KNL PKS
Sbjct: 119 QALDGFLFVVNRDGNIVFVSENVTQYLQYKQEDLVNTSVYNILHEEDRKDFLKNL-PKST 177
Query: 181 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIKE 240
VNG SW+ E R+ SHTFNCRML+K D E+ + + E Q+YETMQCFA+SQP+++ E
Sbjct: 178 VNGVSWTNETQRQKSHTFNCRMLMKTPHDILEDINASPEMRQRYETMQCFALSQPRAMME 237
Query: 241 EGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLV 300
EGEDLQSC+ICVARR+ ER + ESF TR DL GK+ ++DT+++R++M+PG+ED++
Sbjct: 238 EGEDLQSCMICVARRITTGERTFPSNPESFITRHDLSGKVVNIDTNSLRSSMRPGFEDII 297
Query: 301 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT 360
RRCIQ+F + ++G+S S KRH+ E G A + +YRFSL+DGT+V AQTKSKL R+
Sbjct: 298 RRCIQRFFSLNDGQSWS-QKRHYQEAYLNGHAETPVYRFSLADGTIVTAQTKSKLFRNPV 356
Query: 361 TNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDMTLS 420
TN+ +S H L REQN NP+ GQ + P+ +S+ S +P Q + +
Sbjct: 357 TNDRHGFVSTHFLQREQNGYRPNPNPVGQGIRPPMAGCNSSVGG----MSMSPNQGLQMP 412
Query: 421 SNINFPINGPKEQMGMPMGRFGGSGGMNHVS---GMQA-TTPQGSNYALKMNSPSQSSPG 476
S+ + + P M R+GGS + ++ GMQ+ ++ Q +NY L M+SP SPG
Sbjct: 413 SSRAYGLADPSTTGQMSGARYGGSSNIASLTPGPGMQSPSSYQNNNYGLNMSSPPHGSPG 472
Query: 477 MNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSPAGSLHSPVGVCSSTGNSHSYTNSSLNA 536
+ P Q M+SPR+R GSP+I QFSP +HSP+ +TGN HS+++SSL+A
Sbjct: 473 LAPNQQNIMISPRNR------GSPKIASHQFSPVAGVHSPMASSGNTGN-HSFSSSSLSA 525
Query: 537 LQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSKDCFGLYGE--PSE 594
LQA+SEG G SL S+L+SP K L NSP NMN SK+ + DSK G Y + P E
Sbjct: 526 LQAISEGVGTSLLSTLSSPGPK---LDNSP-NMNITQPSKVSNQDSKSPLGFYCDQNPVE 581
Query: 595 GTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQLLTTKSD---- 650
+ Q+ S H +++ S E A+ Q +SKG KLLQLLT SD
Sbjct: 582 SSMCQSNSRDHLSDKESKES-------SVEGAENQRGPLESKGHKKLLQLLTCSSDDRGH 634
Query: 651 -QMEPSPLASSL----------SDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSS 699
+ SPL SS S + ++G + + + HG+ L+EKH+ILH+LLQ+ +S
Sbjct: 635 SSLTNSPLDSSCKESSVSVTSPSGVSSSTSGGVSSTSNMHGSLLQEKHRILHKLLQNGNS 694
Query: 700 PVDLAKLTAEATGKDLSQESSSTAPGSEVTIKQEPVSPKKKE-NALLRYLLDKDDTKDIG 758
P ++AK+TAEATGKD SS T+ G +KQE +SPKKKE NALLRYLLD+DD D
Sbjct: 695 PAEVAKITAEATGKD---TSSITSCGDGNVVKQEQLSPKKKENNALLRYLLDRDDPSDAL 751
Query: 759 LPEITPKLERLDSKTDPASNTKLIAMKTEKE-EMSFEPGDQPGSELDNLEEILDDLQNSQ 817
E+ P++E +D+K +++ + + EK+ ++ E ++ +LDNL+ IL DL +S
Sbjct: 752 SKELQPQVEGVDNKMSQCTSSTIPSSSQEKDPKIKTETSEEGSGDLDNLDAILGDLTSSD 811
Query: 818 LPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTPVGAQKTALRISQSTFNNPRPGQ 877
+ G+ G+ KQ + G L+ SQS
Sbjct: 812 FYNNSISSN-GSHLGT--KQQVFQ---------------GTNSLGLKSSQS--------- 844
Query: 878 LGRLLPNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIP-QPGMMGNQGMIGNQGNLGNSS 936
+ + P N ++L SP G PP++N S + ++P QP + GN M+ +Q N G+S
Sbjct: 845 VQSIRPPYNRA--VSLDSPVSVGSSPPVKNISAFPMLPKQPMLGGNPRMMDSQENYGSSM 902
Query: 937 TGMIGNSASRPTMPSGEWA-PQSSAVRVTCAATTS----------AMNRPVQGGMIRNPA 985
G N T SG+W P S A R+ + S ++ RP GG I
Sbjct: 903 GGPNRNVTVTQTPSSGDWGLPNSKAGRMEPMNSNSMGRPGGDYNTSLPRPALGGSI---- 958
Query: 986 ASIPMRPSSQPGQRQTL--QSQVMNIGPSELEMNMGGPQYSQQQAPPNQTAPWPESILPI 1043
++P+R +S PG R L Q Q++ + P E+ M MG Y Q A NQ WP+ +L +
Sbjct: 959 PTLPLRSNSIPGARPVLQQQQQMLQMRPGEIPMGMGANPYG-QAAASNQLGSWPDGMLSM 1017
Query: 1044 DQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFD--GLEEIDRALG 1101
+Q S +QNR +S DDL+ P E SDE ALLDQL+ L N D GLEEIDRALG
Sbjct: 1018 EQVSHGTQNRPLLRNSLDDLVGPPSNLEGQSDERALLDQLHTLLSNTDATGLEEIDRALG 1077
Query: 1102 IPELVSQSQAVDPEQ--FSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTM 1159
IPELV+Q QA++P+Q F Q++ +M++QKA ++ Q Y +Q QG FH
Sbjct: 1078 IPELVNQGQALEPKQDAFQGQEAAVMMDQKAGLYGQTYPAQGPPMQG--------GFHLQ 1129
Query: 1160 GQRPSYATLRMQ-------PRPGLRPTGLVQ----NQPNQLRLQLQHRLQAQ----QNRQ 1204
GQ PS+ ++ Q P G+ P + N P QLR+QLQ RLQ Q Q+RQ
Sbjct: 1130 GQSPSFNSMMNQMNQQGNFPLQGMHPRANIMRPRTNTPKQLRMQLQQRLQGQQFLNQSRQ 1189
Query: 1205 PLMNQISN-VSNVNLTLRPGVPTQAP-----INAQMLAQRQREILNQHLR---------- 1248
L ++ N + +RP + Q +NAQM+AQR RE+L+ H R
Sbjct: 1190 ALELKMENPTAGGAAVMRPMMQPQVSSQQGFLNAQMVAQRSRELLSHHFRQQRVAMMMQQ 1249
Query: 1249 ---------QRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQF 1299
Q+Q QQQQ QQ+ + Q + P++ A M ++ P +PQA QQF
Sbjct: 1250 QQQQQQQQQQQQQQQQQQQQQQQQQQQTQAFSPPPNVTASPSMDGLLAGPTMPQAPPQQF 1309
Query: 1300 PFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDINGWAQG 1359
P+ PNYG+ QQPDP F ++P + +MS RM +Q+PMMQ QA YQ+ S++ GW G
Sbjct: 1310 PYQPNYGMGQQPDPAFGRVSSPPNAMMSSRMGPSQNPMMQHPQAASIYQS-SEMKGWPSG 1368
Query: 1360 NMGGNSMFSQQSPPHFGQQANTSMYSNNMNINVSMATNTGGMSSMNQMTGQISMTSVTSV 1419
N+ NS FSQQ F Q N ++YS M MN +G + ++ +
Sbjct: 1369 NLARNSSFSQQ---QFAHQGNPAVYS---------------MVHMNGSSGHMGQMNMNPM 1410
Query: 1420 PTSGLSSMGPEQ 1431
P SG+ MGP+Q
Sbjct: 1411 PMSGM-PMGPDQ 1421
>gi|22538457 nuclear receptor coactivator 1 isoform 2 [Homo sapiens]
Length = 1399
Score = 587 bits (1514), Expect = e-167
Identities = 376/891 (42%), Positives = 521/891 (58%), Gaps = 66/891 (7%)
Query: 1 MSGMGENTSDPSRAETRKRKECP-DQLGPSPKRNTEKRNREQENKYIEELAELIFANFND 59
MSG+G+++SDP+ ++ KRK P D L S TEKR REQENKY+EELAEL+ AN +D
Sbjct: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASS----TEKRRREQENKYLEELAELLSANISD 56
Query: 60 IDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMM 119
ID+ + KPDKC ILK+TV QI+ +K E+ + D+VQKSD+SS+ QGVI+K++LGP++
Sbjct: 57 IDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLL 116
Query: 120 LEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKS 179
LEALDGFFFVVN EG +VFVSENVT YL YNQEELMN SVYSILHVGDH EFVKNLLPKS
Sbjct: 117 LEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKS 176
Query: 180 IVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIK 239
+VNG W E RRNSHTFNCRML+ P PD E G +NQEA Q+YE MQCF VSQPKSI+
Sbjct: 177 LVNGVPWPQEATRRNSHTFNCRMLIHP-PD--EPGTENQEACQRYEVMQCFTVSQPKSIQ 233
Query: 240 EEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDL 299
E+GED QSCLIC+ARR+P P + ESF T+QD GKI S+DTS++RAA + GWEDL
Sbjct: 234 EDGEDFQSCLICIARRLP--RPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
Query: 300 VRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQ 359
VR+CI F Q +G SYA++ EV+ +G A S YRF L+DGT+++A TK KL Q
Sbjct: 292 VRKCIYAFF-QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQ 350
Query: 360 TTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPI--SSNSPAHQALCSGN--PGQ 415
+ + ++ +H++ RE + D +NP S SPAH S P
Sbjct: 351 SPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSN 410
Query: 416 DMTLSSNINFP-----INGPKEQMGMPMGRFGGSGGMNHVSGMQ----ATTPQGSNYALK 466
+S+ IN + G FG S G V+ + + Q SN +L
Sbjct: 411 SNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLN 470
Query: 467 MNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSP-AGSLHSPVGVCSS--T 523
+N+ G++ Q +SPR +++ G+A PR+P + F P +L SPVG+ SS
Sbjct: 471 LNNSPMEGTGISLAQ---FMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACN 527
Query: 524 GNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSK 583
N+ SY+N + +LQ ++EG S+G S +SP L+ + QNSP +N P +K S D+K
Sbjct: 528 NNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQP-AKAESKDNK 586
Query: 584 DCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQ 643
+ + E + ++ ND +DG S+ S+ KL+Q
Sbjct: 587 EIASILNEMIQSDNSSSDGKPLDSGLLHNND---------RLSDGDSKY--SQTSHKLVQ 635
Query: 644 LLTTKSD-QMEPSPLASSLSD-------TNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQ 695
LLTT ++ Q+ + + +S D +N S S GS + +SL E+HKILHRLLQ
Sbjct: 636 LLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQ 695
Query: 696 DSSSPVDLAKLTAEATGKDLSQESSSTA--PGSEVTIKQEPVSPKKKE---NALLRYLLD 750
+ SP D+ L+ E KD + S S +IK E + KKKE + LLRYLLD
Sbjct: 696 E-GSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLD 754
Query: 751 KDD-----TKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDN 805
KD+ T ++ L ++ K+E+ + + DP + K EE+ E Q ++LD
Sbjct: 755 KDEKDLRSTPNLSLDDVKVKVEKKE-QMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQ 813
Query: 806 LEEILDDLQN-SQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTP 855
+++L L+ +QLP L R G+V I ++++ + +++ P
Sbjct: 814 FDQLLPTLEKAAQLPGLCETDRMD---GAVTSVTIKSEILPASLQSATARP 861
Score = 226 bits (576), Expect = 1e-58
Identities = 283/1082 (26%), Positives = 446/1082 (41%), Gaps = 214/1082 (19%)
Query: 521 SSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSL 580
+++G S N S+N ++S HGV+ S+L S NM +++ S
Sbjct: 377 TNSGMSIPRVNPSVNP--SISPAHGVARSSTLPP----------SNSNMVSTRINRQQSS 424
Query: 581 DSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTK 640
D S+G+ G C PG Q N SS+ ++ L++S +
Sbjct: 425 DLHSSSHSNSSNSQGSFG-----CSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGT 479
Query: 641 LLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSP 700
+ L S + + + S L+ + S P + ST + + + + S S
Sbjct: 480 GISLAQFMSPRRQ---VTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNR-SYSN 535
Query: 701 VDLAKLTAEATGKDLSQESSSTAP--------GSEVTIKQEPVSPKKKEN----ALLRYL 748
+ + L G + S S+++P S + +P + K+N ++L +
Sbjct: 536 IPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEM 595
Query: 749 LDKDDTK------DIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSE 802
+ D++ D GL +L DSK S+ KL+ + T E D S
Sbjct: 596 IQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSH-KLVQLLTTTAEQQLRHADIDTSC 654
Query: 803 LDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQ---------LTAE---- 849
D L NS + P + + ++ I++ L+Q L+ E
Sbjct: 655 KDVLS--CTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKK 712
Query: 850 NSPVTPV-------GAQKTALRISQSTFNNPRPGQLGRLLPNQ---------NLPLDITL 893
+S T V G L + S + QL R L ++ NL LD
Sbjct: 713 DSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVK 772
Query: 894 QSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGE 953
P + P P + + +L +P+ E
Sbjct: 773 VKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQ----------LLPTLE 822
Query: 954 WAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSE 1013
A Q + T + + ++ ++ S RP+S+ + L+ +
Sbjct: 823 KAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEA------- 875
Query: 1014 LEMNMGGPQYSQQQAPPNQTAPWPES-ILPIDQASFASQNRQPFGSSPDDLLCPHPAAES 1072
++ G P Q PW + + I+Q+ Q S D+LLCP E
Sbjct: 876 IDNQFGQPGTGDQ-------IPWTNNTVTAINQSK---SEDQCISSQLDELLCPPTTVEG 925
Query: 1073 PSDEGALLDQL--YLALRNFDGLEEIDRALGIPELVSQSQAVD--PEQFSSQDSN--IML 1126
+DE ALL+QL +L+ ++ L E+DRALGI +LV Q +D E+F Q + +++
Sbjct: 926 RNDEKALLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVLSERFPPQQATPPLIM 984
Query: 1127 EQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRP---------GLR 1177
E++ ++ Q Y+S + A + P + Q+PS T+ +Q P G++
Sbjct: 985 EERPNLYSQPYSSPSPTAN-----LPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQ 1039
Query: 1178 PTGLVQNQP---NQLRLQLQHRLQAQQ-----NRQPLMNQISNVSNVNLTLRPG----VP 1225
P + P NQLRLQLQ RLQ QQ NRQ ++NQ + + V + +R G +
Sbjct: 1040 PRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQIT 1099
Query: 1226 TQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQ--GLNMTPSMVAPSGMP 1283
Q P+NAQMLAQRQRE+ +Q RQRQ+ QQQ R ++MR Q G N+ PS SG+P
Sbjct: 1100 PQPPLNAQMLAQRQRELYSQQHRQRQLIQQQ----RAMLMRQQSFGNNLPPS----SGLP 1151
Query: 1284 ATMSNPRIPQANAQQFPFPPNYGISQQPDP--------------------------GFTG 1317
M NPR+PQ QQFP+PPNYG + P G TG
Sbjct: 1152 VQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTG 1211
Query: 1318 --------ATTPQ---------------------SPLMSPRMAHTQSP-------MMQQS 1341
PQ +P +SP + P ++QQ+
Sbjct: 1212 NIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
Query: 1342 QANPAYQAPSDINGWAQGNMGGNSMFSQ--QSPPHFGQQANTSMYSNNMNINVSMATNTG 1399
YQ+P D+ W QG +G N++FSQ Q+ P A +Y NNM+I VSMA
Sbjct: 1272 PPASGYQSP-DMKAWQQGAIGNNNVFSQAVQNQP---TPAQPGVY-NNMSITVSMAGGNT 1326
Query: 1400 GMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDT 1459
+ +MN M Q+ M +S+ G++++ PEQ+NDPALR L+ NQL D++K E D
Sbjct: 1327 NVQNMNPMMAQMQM---SSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADG 1383
Query: 1460 TR 1461
T+
Sbjct: 1384 TQ 1385
>gi|22538459 nuclear receptor coactivator 1 isoform 3 [Homo sapiens]
Length = 1440
Score = 587 bits (1514), Expect = e-167
Identities = 376/891 (42%), Positives = 521/891 (58%), Gaps = 66/891 (7%)
Query: 1 MSGMGENTSDPSRAETRKRKECP-DQLGPSPKRNTEKRNREQENKYIEELAELIFANFND 59
MSG+G+++SDP+ ++ KRK P D L S TEKR REQENKY+EELAEL+ AN +D
Sbjct: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASS----TEKRRREQENKYLEELAELLSANISD 56
Query: 60 IDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMM 119
ID+ + KPDKC ILK+TV QI+ +K E+ + D+VQKSD+SS+ QGVI+K++LGP++
Sbjct: 57 IDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLL 116
Query: 120 LEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKS 179
LEALDGFFFVVN EG +VFVSENVT YL YNQEELMN SVYSILHVGDH EFVKNLLPKS
Sbjct: 117 LEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKS 176
Query: 180 IVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIK 239
+VNG W E RRNSHTFNCRML+ P PD E G +NQEA Q+YE MQCF VSQPKSI+
Sbjct: 177 LVNGVPWPQEATRRNSHTFNCRMLIHP-PD--EPGTENQEACQRYEVMQCFTVSQPKSIQ 233
Query: 240 EEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDL 299
E+GED QSCLIC+ARR+P P + ESF T+QD GKI S+DTS++RAA + GWEDL
Sbjct: 234 EDGEDFQSCLICIARRLP--RPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
Query: 300 VRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQ 359
VR+CI F Q +G SYA++ EV+ +G A S YRF L+DGT+++A TK KL Q
Sbjct: 292 VRKCIYAFF-QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQ 350
Query: 360 TTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPI--SSNSPAHQALCSGN--PGQ 415
+ + ++ +H++ RE + D +NP S SPAH S P
Sbjct: 351 SPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSN 410
Query: 416 DMTLSSNINFP-----INGPKEQMGMPMGRFGGSGGMNHVSGMQ----ATTPQGSNYALK 466
+S+ IN + G FG S G V+ + + Q SN +L
Sbjct: 411 SNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLN 470
Query: 467 MNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSP-AGSLHSPVGVCSS--T 523
+N+ G++ Q +SPR +++ G+A PR+P + F P +L SPVG+ SS
Sbjct: 471 LNNSPMEGTGISLAQ---FMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACN 527
Query: 524 GNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSK 583
N+ SY+N + +LQ ++EG S+G S +SP L+ + QNSP +N P +K S D+K
Sbjct: 528 NNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQP-AKAESKDNK 586
Query: 584 DCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQ 643
+ + E + ++ ND +DG S+ S+ KL+Q
Sbjct: 587 EIASILNEMIQSDNSSSDGKPLDSGLLHNND---------RLSDGDSKY--SQTSHKLVQ 635
Query: 644 LLTTKSD-QMEPSPLASSLSD-------TNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQ 695
LLTT ++ Q+ + + +S D +N S S GS + +SL E+HKILHRLLQ
Sbjct: 636 LLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQ 695
Query: 696 DSSSPVDLAKLTAEATGKDLSQESSSTA--PGSEVTIKQEPVSPKKKE---NALLRYLLD 750
+ SP D+ L+ E KD + S S +IK E + KKKE + LLRYLLD
Sbjct: 696 E-GSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLD 754
Query: 751 KDD-----TKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDN 805
KD+ T ++ L ++ K+E+ + + DP + K EE+ E Q ++LD
Sbjct: 755 KDEKDLRSTPNLSLDDVKVKVEKKE-QMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQ 813
Query: 806 LEEILDDLQN-SQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTP 855
+++L L+ +QLP L R G+V I ++++ + +++ P
Sbjct: 814 FDQLLPTLEKAAQLPGLCETDRMD---GAVTSVTIKSEILPASLQSATARP 861
Score = 226 bits (576), Expect = 1e-58
Identities = 283/1082 (26%), Positives = 446/1082 (41%), Gaps = 214/1082 (19%)
Query: 521 SSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSL 580
+++G S N S+N ++S HGV+ S+L S NM +++ S
Sbjct: 377 TNSGMSIPRVNPSVNP--SISPAHGVARSSTLPP----------SNSNMVSTRINRQQSS 424
Query: 581 DSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTK 640
D S+G+ G C PG Q N SS+ ++ L++S +
Sbjct: 425 DLHSSSHSNSSNSQGSFG-----CSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGT 479
Query: 641 LLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSP 700
+ L S + + + S L+ + S P + ST + + + + S S
Sbjct: 480 GISLAQFMSPRRQ---VTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNR-SYSN 535
Query: 701 VDLAKLTAEATGKDLSQESSSTAP--------GSEVTIKQEPVSPKKKEN----ALLRYL 748
+ + L G + S S+++P S + +P + K+N ++L +
Sbjct: 536 IPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEM 595
Query: 749 LDKDDTK------DIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSE 802
+ D++ D GL +L DSK S+ KL+ + T E D S
Sbjct: 596 IQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSH-KLVQLLTTTAEQQLRHADIDTSC 654
Query: 803 LDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQ---------LTAE---- 849
D L NS + P + + ++ I++ L+Q L+ E
Sbjct: 655 KDVLS--CTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKK 712
Query: 850 NSPVTPV-------GAQKTALRISQSTFNNPRPGQLGRLLPNQ---------NLPLDITL 893
+S T V G L + S + QL R L ++ NL LD
Sbjct: 713 DSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVK 772
Query: 894 QSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGE 953
P + P P + + +L +P+ E
Sbjct: 773 VKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQ----------LLPTLE 822
Query: 954 WAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSE 1013
A Q + T + + ++ ++ S RP+S+ + L+ +
Sbjct: 823 KAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEA------- 875
Query: 1014 LEMNMGGPQYSQQQAPPNQTAPWPES-ILPIDQASFASQNRQPFGSSPDDLLCPHPAAES 1072
++ G P Q PW + + I+Q+ Q S D+LLCP E
Sbjct: 876 IDNQFGQPGTGDQ-------IPWTNNTVTAINQSK---SEDQCISSQLDELLCPPTTVEG 925
Query: 1073 PSDEGALLDQL--YLALRNFDGLEEIDRALGIPELVSQSQAVD--PEQFSSQDSN--IML 1126
+DE ALL+QL +L+ ++ L E+DRALGI +LV Q +D E+F Q + +++
Sbjct: 926 RNDEKALLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVLSERFPPQQATPPLIM 984
Query: 1127 EQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRP---------GLR 1177
E++ ++ Q Y+S + A + P + Q+PS T+ +Q P G++
Sbjct: 985 EERPNLYSQPYSSPSPTAN-----LPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQ 1039
Query: 1178 PTGLVQNQP---NQLRLQLQHRLQAQQ-----NRQPLMNQISNVSNVNLTLRPG----VP 1225
P + P NQLRLQLQ RLQ QQ NRQ ++NQ + + V + +R G +
Sbjct: 1040 PRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQIT 1099
Query: 1226 TQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQ--GLNMTPSMVAPSGMP 1283
Q P+NAQMLAQRQRE+ +Q RQRQ+ QQQ R ++MR Q G N+ PS SG+P
Sbjct: 1100 PQPPLNAQMLAQRQRELYSQQHRQRQLIQQQ----RAMLMRQQSFGNNLPPS----SGLP 1151
Query: 1284 ATMSNPRIPQANAQQFPFPPNYGISQQPDP--------------------------GFTG 1317
M NPR+PQ QQFP+PPNYG + P G TG
Sbjct: 1152 VQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTG 1211
Query: 1318 --------ATTPQ---------------------SPLMSPRMAHTQSP-------MMQQS 1341
PQ +P +SP + P ++QQ+
Sbjct: 1212 NIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
Query: 1342 QANPAYQAPSDINGWAQGNMGGNSMFSQ--QSPPHFGQQANTSMYSNNMNINVSMATNTG 1399
YQ+P D+ W QG +G N++FSQ Q+ P A +Y NNM+I VSMA
Sbjct: 1272 PPASGYQSP-DMKAWQQGAIGNNNVFSQAVQNQP---TPAQPGVY-NNMSITVSMAGGNT 1326
Query: 1400 GMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDT 1459
+ +MN M Q+ M +S+ G++++ PEQ+NDPALR L+ NQL D++K E D
Sbjct: 1327 NVQNMNPMMAQMQM---SSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADG 1383
Query: 1460 TR 1461
T+
Sbjct: 1384 TQ 1385
>gi|22538455 nuclear receptor coactivator 1 isoform 1 [Homo sapiens]
Length = 1441
Score = 587 bits (1514), Expect = e-167
Identities = 376/891 (42%), Positives = 521/891 (58%), Gaps = 66/891 (7%)
Query: 1 MSGMGENTSDPSRAETRKRKECP-DQLGPSPKRNTEKRNREQENKYIEELAELIFANFND 59
MSG+G+++SDP+ ++ KRK P D L S TEKR REQENKY+EELAEL+ AN +D
Sbjct: 1 MSGLGDSSSDPANPDSHKRKGSPCDTLASS----TEKRRREQENKYLEELAELLSANISD 56
Query: 60 IDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMM 119
ID+ + KPDKC ILK+TV QI+ +K E+ + D+VQKSD+SS+ QGVI+K++LGP++
Sbjct: 57 IDSLSVKPDKCKILKKTVDQIQLMKRMEQEKSTTDDDVQKSDISSSSQGVIEKESLGPLL 116
Query: 120 LEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKS 179
LEALDGFFFVVN EG +VFVSENVT YL YNQEELMN SVYSILHVGDH EFVKNLLPKS
Sbjct: 117 LEALDGFFFVVNCEGRIVFVSENVTSYLGYNQEELMNTSVYSILHVGDHAEFVKNLLPKS 176
Query: 180 IVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFAVSQPKSIK 239
+VNG W E RRNSHTFNCRML+ P PD E G +NQEA Q+YE MQCF VSQPKSI+
Sbjct: 177 LVNGVPWPQEATRRNSHTFNCRMLIHP-PD--EPGTENQEACQRYEVMQCFTVSQPKSIQ 233
Query: 240 EEGEDLQSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDL 299
E+GED QSCLIC+ARR+P P + ESF T+QD GKI S+DTS++RAA + GWEDL
Sbjct: 234 EDGEDFQSCLICIARRLP--RPPAITGVESFMTKQDTTGKIISIDTSSLRAAGRTGWEDL 291
Query: 300 VRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQ 359
VR+CI F Q +G SYA++ EV+ +G A S YRF L+DGT+++A TK KL Q
Sbjct: 292 VRKCIYAFF-QPQGREPSYARQLFQEVMTRGTASSPSYRFILNDGTMLSAHTKCKLCYPQ 350
Query: 360 TTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPI--SSNSPAHQALCSGN--PGQ 415
+ + ++ +H++ RE + D +NP S SPAH S P
Sbjct: 351 SPDMQPFIMGIHIIDREHSGLSPQDDTNSGMSIPRVNPSVNPSISPAHGVARSSTLPPSN 410
Query: 416 DMTLSSNINFP-----INGPKEQMGMPMGRFGGSGGMNHVSGMQ----ATTPQGSNYALK 466
+S+ IN + G FG S G V+ + + Q SN +L
Sbjct: 411 SNMVSTRINRQQSSDLHSSSHSNSSNSQGSFGCSPGSQIVANVALNQGQASSQSSNPSLN 470
Query: 467 MNSPSQSSPGMNPGQPTSMLSPRHRMSPGVAGSPRIPPSQFSP-AGSLHSPVGVCSS--T 523
+N+ G++ Q +SPR +++ G+A PR+P + F P +L SPVG+ SS
Sbjct: 471 LNNSPMEGTGISLAQ---FMSPRRQVTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACN 527
Query: 524 GNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSLDSK 583
N+ SY+N + +LQ ++EG S+G S +SP L+ + QNSP +N P +K S D+K
Sbjct: 528 NNNRSYSNIPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQP-AKAESKDNK 586
Query: 584 DCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTKLLQ 643
+ + E + ++ ND +DG S+ S+ KL+Q
Sbjct: 587 EIASILNEMIQSDNSSSDGKPLDSGLLHNND---------RLSDGDSKY--SQTSHKLVQ 635
Query: 644 LLTTKSD-QMEPSPLASSLSD-------TNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQ 695
LLTT ++ Q+ + + +S D +N S S GS + +SL E+HKILHRLLQ
Sbjct: 636 LLTTTAEQQLRHADIDTSCKDVLSCTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQ 695
Query: 696 DSSSPVDLAKLTAEATGKDLSQESSSTA--PGSEVTIKQEPVSPKKKE---NALLRYLLD 750
+ SP D+ L+ E KD + S S +IK E + KKKE + LLRYLLD
Sbjct: 696 E-GSPSDITTLSVEPDKKDSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLD 754
Query: 751 KDD-----TKDIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSELDN 805
KD+ T ++ L ++ K+E+ + + DP + K EE+ E Q ++LD
Sbjct: 755 KDEKDLRSTPNLSLDDVKVKVEKKE-QMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQ 813
Query: 806 LEEILDDLQN-SQLPQLFPDTRPGAPAGSVDKQAIINDLMQLTAENSPVTP 855
+++L L+ +QLP L R G+V I ++++ + +++ P
Sbjct: 814 FDQLLPTLEKAAQLPGLCETDRMD---GAVTSVTIKSEILPASLQSATARP 861
Score = 226 bits (577), Expect = 1e-58
Identities = 283/1083 (26%), Positives = 447/1083 (41%), Gaps = 214/1083 (19%)
Query: 521 SSTGNSHSYTNSSLNALQALSEGHGVSLGSSLASPDLKMGNLQNSPVNMNPPPLSKMGSL 580
+++G S N S+N ++S HGV+ S+L S NM +++ S
Sbjct: 377 TNSGMSIPRVNPSVNP--SISPAHGVARSSTLPP----------SNSNMVSTRINRQQSS 424
Query: 581 DSKDCFGLYGEPSEGTTGQAESSCHPGEQKETNDPNLPPAVSSERADGQSRLHDSKGQTK 640
D S+G+ G C PG Q N SS+ ++ L++S +
Sbjct: 425 DLHSSSHSNSSNSQGSFG-----CSPGSQIVANVALNQGQASSQSSNPSLNLNNSPMEGT 479
Query: 641 LLQLLTTKSDQMEPSPLASSLSDTNKDSTGSLPGSGSTHGTSLKEKHKILHRLLQDSSSP 700
+ L S + + + S L+ + S P + ST + + + + S S
Sbjct: 480 GISLAQFMSPRRQ---VTSGLATRPRMPNNSFPPNISTLSSPVGMTSSACNNNNR-SYSN 535
Query: 701 VDLAKLTAEATGKDLSQESSSTAP--------GSEVTIKQEPVSPKKKEN----ALLRYL 748
+ + L G + S S+++P S + +P + K+N ++L +
Sbjct: 536 IPVTSLQGMNEGPNNSVGFSASSPVLRQMSSQNSPSRLNIQPAKAESKDNKEIASILNEM 595
Query: 749 LDKDDTK------DIGLPEITPKLERLDSKTDPASNTKLIAMKTEKEEMSFEPGDQPGSE 802
+ D++ D GL +L DSK S+ KL+ + T E D S
Sbjct: 596 IQSDNSSSDGKPLDSGLLHNNDRLSDGDSKYSQTSH-KLVQLLTTTAEQQLRHADIDTSC 654
Query: 803 LDNLEEILDDLQNSQLPQLFPDTRPGAPAGSVDKQAIINDLMQ---------LTAE---- 849
D L NS + P + + ++ I++ L+Q L+ E
Sbjct: 655 KDVLS--CTGTSNSASANSSGGSCPSSHSSLTERHKILHRLLQEGSPSDITTLSVEPDKK 712
Query: 850 NSPVTPV-------GAQKTALRISQSTFNNPRPGQLGRLLPNQ---------NLPLDITL 893
+S T V G L + S + QL R L ++ NL LD
Sbjct: 713 DSASTSVSVTGQVQGNSSIKLELDASKKKESKDHQLLRYLLDKDEKDLRSTPNLSLDDVK 772
Query: 894 QSPTGAGPFPPIRNSSPYSVIPQPGMMGNQGMIGNQGNLGNSSTGMIGNSASRPTMPSGE 953
P + P P + + +L +P+ E
Sbjct: 773 VKVEKKEQMDPCNTNPTPMTKPTPEEIKLEAQSQFTADLDQFDQ----------LLPTLE 822
Query: 954 WAPQSSAVRVTCAATTSAMNRPVQGGMIRNPAASIPMRPSSQPGQRQTLQSQVMNIGPSE 1013
A Q + T + + ++ ++ S RP+S+ + L+ +
Sbjct: 823 KAAQLPGLCETDRMDGAVTSVTIKSEILPASLQSATARPTSRLNRLPELELEA------- 875
Query: 1014 LEMNMGGPQYSQQQAPPNQTAPWPES-ILPIDQASFASQNRQPFGSSPDDLLCPHPAAES 1072
++ G P Q PW + + I+Q+ Q S D+LLCP E
Sbjct: 876 IDNQFGQPGTGDQ-------IPWTNNTVTAINQSK---SEDQCISSQLDELLCPPTTVEG 925
Query: 1073 PSDEGALLDQL--YLALRNFDGLEEIDRALGIPELVSQSQAVD--PEQFSSQDSN--IML 1126
+DE ALL+QL +L+ ++ L E+DRALGI +LV Q +D E+F Q + +++
Sbjct: 926 RNDEKALLEQLVSFLSGKDETELAELDRALGIDKLV-QGGGLDVLSERFPPQQATPPLIM 984
Query: 1127 EQKAPVFPQQYASQAQMAQGSYSPMQDPNFHTMGQRPSYATLRMQPRP---------GLR 1177
E++ ++ Q Y+S + A + P + Q+PS T+ +Q P G++
Sbjct: 985 EERPNLYSQPYSSPSPTAN-----LPSPFQGMVRQKPSLGTMPVQVTPPRGAFSPGMGMQ 1039
Query: 1178 PTGLVQNQP---NQLRLQLQHRLQAQQ-----NRQPLMNQISNVSNVNLTLRPG----VP 1225
P + P NQLRLQLQ RLQ QQ NRQ ++NQ + + V + +R G +
Sbjct: 1040 PRQTLNRPPAAPNQLRLQLQQRLQGQQQLIHQNRQAILNQFAATAPVGINMRSGMQQQIT 1099
Query: 1226 TQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQ--GLNMTPSMVAPSGMP 1283
Q P+NAQMLAQRQRE+ +Q RQRQ+ QQQ R ++MR Q G N+ PS SG+P
Sbjct: 1100 PQPPLNAQMLAQRQRELYSQQHRQRQLIQQQ----RAMLMRQQSFGNNLPPS----SGLP 1151
Query: 1284 ATMSNPRIPQANAQQFPFPPNYGISQQPDP--------------------------GFTG 1317
M NPR+PQ QQFP+PPNYG + P G TG
Sbjct: 1152 VQMGNPRLPQGAPQQFPYPPNYGTNPGTPPASTSPFSQLAANPEASLANRNSMVSRGMTG 1211
Query: 1318 --------ATTPQ---------------------SPLMSPRMAHTQSP-------MMQQS 1341
PQ +P +SP + P ++QQ+
Sbjct: 1212 NIGGQFGTGINPQMQQNVFQYPGAGMVPQGEANFAPSLSPGSSMVPMPIPPPQSSLLQQT 1271
Query: 1342 QANPAYQAPSDINGWAQGNMGGNSMFSQ--QSPPHFGQQANTSMYSNNMNINVSMATNTG 1399
YQ+P D+ W QG +G N++FSQ Q+ P A +Y NNM+I VSMA
Sbjct: 1272 PPASGYQSP-DMKAWQQGAIGNNNVFSQAVQNQP---TPAQPGVY-NNMSITVSMAGGNT 1326
Query: 1400 GMSSMNQMTGQISMTSVTSVPTSGLSSMGPEQVNDPALRGGNLFPNQLPGMDMIKQEGDT 1459
+ +MN M Q+ M +S+ G++++ PEQ+NDPALR L+ NQL D++K E D
Sbjct: 1327 NVQNMNPMMAQMQM---SSLQMPGMNTVCPEQINDPALRHTGLYCNQLSSTDLLKTEADG 1383
Query: 1460 TRK 1462
T++
Sbjct: 1384 TQQ 1386
>gi|4758010 clock [Homo sapiens]
Length = 846
Score = 89.7 bits (221), Expect = 2e-17
Identities = 85/354 (24%), Positives = 162/354 (45%), Gaps = 32/354 (9%)
Query: 31 KRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAA 90
+ +EK+ R+Q N I+EL ++ N K DK +L++++ +R K +E A
Sbjct: 39 RNKSEKKRRDQFNVLIKELGSMLPGNAR-------KMDKSTVLQKSIDFLR--KHKEITA 89
Query: 91 AANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYN 150
++ E+++ D T + + +MLEALDGFF + +G++++VSE+VT L +
Sbjct: 90 QSDASEIRQ-DWKPT---FLSNEEFTQLMLEALDGFFLAIMTDGSIIYVSESVTSLLEHL 145
Query: 151 QEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPR-RNSHTFNCRMLVKPLPD 209
+L+++S+++ + G+H+E K +L ++ S + E + +N F C ML +
Sbjct: 146 PSDLVDQSIFNFIPEGEHSEVYK-ILSTHLLESDSLTPEYLKSKNQLEFCCHMLRGTIDP 204
Query: 210 SEEEGHDNQEAHQKYETMQCFAVSQ--------PKSIKEEGEDLQSCLICVARRVP---M 258
E ++ + ++++ + S ++ + ED + C + R +
Sbjct: 205 KEPSTYEYVKFIGNFKSLNSVSSSAHNGFEGTIQRTHRPSYED-RVCFVATVRLATPQFI 263
Query: 259 KER-PVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVS 317
KE V +E FT+R L+ K LD RA G+ + H + +
Sbjct: 264 KEMCTVEEPNEEFTSRHSLEWKFLFLD---HRAPPIIGYLPFEVLGTSGYDYYHVDDLEN 320
Query: 318 YAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLH 371
AK H H +++ G S YRF + QT + Q + P+ ++ H
Sbjct: 321 LAKCHEH-LMQYGKGKSCYYRFLTKGQQWIWLQTHYYITYHQWNSRPEFIVCTH 373
>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
[Homo sapiens]
Length = 636
Score = 83.6 bits (205), Expect = 1e-15
Identities = 96/416 (23%), Positives = 169/416 (40%), Gaps = 61/416 (14%)
Query: 34 TEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAAAN 93
TEKR R++ N IEEL+ +I + K DK +L+ V+ +R +K +
Sbjct: 115 TEKRRRDKMNNLIEELSAMI----PQCNPMARKLDKLTVLRMAVQHLRSLKGLTNSYVG- 169
Query: 94 IDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLE-GNVVFVSENVTQYLRYNQE 152
S+ + + L ++L+ +GF FVV E G ++FVS++V++ L Y+Q
Sbjct: 170 ---------SNYRPSFLQDNELRHLILKTAEGFLFVVGCERGKILFVSKSVSKILNYDQA 220
Query: 153 ELMNKSVYSILHVGDHTEFVKNLLPKSIVNG-----GSWSGEPPRRNSH----------- 196
L +S++ LH D + VK L ++ + +G N H
Sbjct: 221 SLTGQSLFDFLHPKDVAK-VKEQLSSFDISPREKLIDAKTGLQVHSNLHAGRTRVYSGSR 279
Query: 197 -TFNCRMLVKPLPDSEEEG---HDNQEAHQKYETMQC--FAVSQPKSIKEEGEDLQS--- 247
+F CR+ + EE G + ++ H+K+ T+ C + S P +I E+ S
Sbjct: 280 RSFFCRIKSCKISVKEEHGCLPNSKKKEHRKFYTIHCTGYLRSWPPNIVGMEEERNSKKD 339
Query: 248 -----CLICVARR----VPMKERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWED 298
CL+ + R VP + F TR + GK +D E
Sbjct: 340 NSNFTCLVAIGRLQPYIVPQNSGEINVKPTEFITRFAVNGKFVYVDQRATAILGYLPQEL 399
Query: 299 LVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRS 358
L C + F H+ + + +H + + + Y+F DG+ V +++ +
Sbjct: 400 LGTSCYEYF---HQDDHNNLTDKHKAVLQSKEKILTDSYKFRAKDGSFVTLKSQWFSFTN 456
Query: 359 QTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPG 414
T E + ++S+ N V+ G+ P + SS + Q+ C PG
Sbjct: 457 PWTKELEYIVSV-------NTLVLGHSEPGEASFLPCSSQSSEESSRQS-CMSVPG 504
>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
isoform b [Homo sapiens]
Length = 582
Score = 77.4 bits (189), Expect = 9e-14
Identities = 117/518 (22%), Positives = 195/518 (37%), Gaps = 95/518 (18%)
Query: 35 EKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKA-AAAN 93
EKR R++ N +I+ELA L+ + + K DK +L+ V+ ++ ++ AN
Sbjct: 38 EKRRRDKMNSFIDELASLV----PTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEAN 93
Query: 94 IDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLE-GNVVFVSENVTQYLRYNQE 152
SD D L ++L A DGF FVV + G ++FVSE+V + L Y+Q
Sbjct: 94 YKPTFLSD-----------DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQN 142
Query: 153 ELMNKSVYSILHVGDHTEFVKNL-------------------LPKSIVNGGSWSGEPPRR 193
+L+ +S++ LH D + + L + I G S RR
Sbjct: 143 DLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARR 202
Query: 194 NSHTFNCRMLV-KPLPDSEEEGHDNQEAHQKYETMQC------FAVSQPKSIKEEGEDLQ 246
+F CRM +P E++ + + +K C + S P + ED +
Sbjct: 203 ---SFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 259
Query: 247 --------SCLICVARR----VPMK-ERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMK 293
SCL+ + R VP + S + +R + GK +D
Sbjct: 260 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY 319
Query: 294 PGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLR-QGLAFSQIYRFSLSDGTLVAAQTK 352
E L C + FH + + + H +VL+ + + Y+F + DG+ + +++
Sbjct: 320 LPQELLGTSCYEYFHQ----DDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSR 375
Query: 353 SKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGN 412
+ T E + ++S N V+ N + P L +
Sbjct: 376 WFSFMNPWTKEVEYIVS-------TNTVVL------------ANVLEGGDPTFPQLTASP 416
Query: 413 PGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQ 472
D L S P G+P G G+G + + + ++ S
Sbjct: 417 HSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIH------RIRGSSP 470
Query: 473 SSPGMNPGQPTSMLSPRHRMSPG-----VAGSPRIPPS 505
SS G +P TS P SPG G+P IP S
Sbjct: 471 SSCGSSPLNITS-TPPPDASSPGGKKILNGGTPDIPSS 507
>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 77.4 bits (189), Expect = 9e-14
Identities = 117/518 (22%), Positives = 195/518 (37%), Gaps = 95/518 (18%)
Query: 35 EKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKA-AAAN 93
EKR R++ N +I+ELA L+ + + K DK +L+ V+ ++ ++ AN
Sbjct: 81 EKRRRDKMNSFIDELASLV----PTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEAN 136
Query: 94 IDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLE-GNVVFVSENVTQYLRYNQE 152
SD D L ++L A DGF FVV + G ++FVSE+V + L Y+Q
Sbjct: 137 YKPTFLSD-----------DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQN 185
Query: 153 ELMNKSVYSILHVGDHTEFVKNL-------------------LPKSIVNGGSWSGEPPRR 193
+L+ +S++ LH D + + L + I G S RR
Sbjct: 186 DLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARR 245
Query: 194 NSHTFNCRMLV-KPLPDSEEEGHDNQEAHQKYETMQC------FAVSQPKSIKEEGEDLQ 246
+F CRM +P E++ + + +K C + S P + ED +
Sbjct: 246 ---SFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 302
Query: 247 --------SCLICVARR----VPMK-ERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMK 293
SCL+ + R VP + S + +R + GK +D
Sbjct: 303 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY 362
Query: 294 PGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLR-QGLAFSQIYRFSLSDGTLVAAQTK 352
E L C + FH + + + H +VL+ + + Y+F + DG+ + +++
Sbjct: 363 LPQELLGTSCYEYFHQ----DDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSR 418
Query: 353 SKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGN 412
+ T E + ++S N V+ N + P L +
Sbjct: 419 WFSFMNPWTKEVEYIVS-------TNTVVL------------ANVLEGGDPTFPQLTASP 459
Query: 413 PGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQ 472
D L S P G+P G G+G + + + ++ S
Sbjct: 460 HSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIH------RIRGSSP 513
Query: 473 SSPGMNPGQPTSMLSPRHRMSPG-----VAGSPRIPPS 505
SS G +P TS P SPG G+P IP S
Sbjct: 514 SSCGSSPLNITS-TPPPDASSPGGKKILNGGTPDIPSS 550
>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
isoform a [Homo sapiens]
Length = 625
Score = 77.4 bits (189), Expect = 9e-14
Identities = 117/518 (22%), Positives = 195/518 (37%), Gaps = 95/518 (18%)
Query: 35 EKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKA-AAAN 93
EKR R++ N +I+ELA L+ + + K DK +L+ V+ ++ ++ AN
Sbjct: 81 EKRRRDKMNSFIDELASLV----PTCNAMSRKLDKLTVLRMAVQHMKTLRGATNPYTEAN 136
Query: 94 IDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLE-GNVVFVSENVTQYLRYNQE 152
SD D L ++L A DGF FVV + G ++FVSE+V + L Y+Q
Sbjct: 137 YKPTFLSD-----------DELKHLILRAADGFLFVVGCDRGKILFVSESVFKILNYSQN 185
Query: 153 ELMNKSVYSILHVGDHTEFVKNL-------------------LPKSIVNGGSWSGEPPRR 193
+L+ +S++ LH D + + L + I G S RR
Sbjct: 186 DLIGQSLFDYLHPKDIAKVKEQLSSSDTAPRERLIDAKTGLPVKTDITPGPSRLCSGARR 245
Query: 194 NSHTFNCRMLV-KPLPDSEEEGHDNQEAHQKYETMQC------FAVSQPKSIKEEGEDLQ 246
+F CRM +P E++ + + +K C + S P + ED +
Sbjct: 246 ---SFFCRMKCNRPSVKVEDKDFPSTCSKKKDRKSFCTIHSTGYLKSWPPTKMGLDEDNE 302
Query: 247 --------SCLICVARR----VPMK-ERPVLPSSESFTTRQDLQGKITSLDTSTMRAAMK 293
SCL+ + R VP + S + +R + GK +D
Sbjct: 303 PDNEGCNLSCLVAIGRLHSHVVPQPVNGEIRVKSMEYVSRHAIDGKFVFVDQRATAILAY 362
Query: 294 PGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLR-QGLAFSQIYRFSLSDGTLVAAQTK 352
E L C + FH + + + H +VL+ + + Y+F + DG+ + +++
Sbjct: 363 LPQELLGTSCYEYFHQ----DDIGHLAECHRQVLQTREKITTNCYKFKIKDGSFITLRSR 418
Query: 353 SKLIRSQTTNEPQLVISLHMLHREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGN 412
+ T E + ++S N V+ N + P L +
Sbjct: 419 WFSFMNPWTKEVEYIVS-------TNTVVL------------ANVLEGGDPTFPQLTASP 459
Query: 413 PGQDMTLSSNINFPINGPKEQMGMPMGRFGGSGGMNHVSGMQATTPQGSNYALKMNSPSQ 472
D L S P G+P G G+G + + + ++ S
Sbjct: 460 HSMDSMLPSGEGGPKRTHPTVPGIPGGTRAGAGKIGRMIAEEIMEIH------RIRGSSP 513
Query: 473 SSPGMNPGQPTSMLSPRHRMSPG-----VAGSPRIPPS 505
SS G +P TS P SPG G+P IP S
Sbjct: 514 SSCGSSPLNITS-TPPPDASSPGGKKILNGGTPDIPSS 550
>gi|31077211 hypoxia-inducible factor 1, alpha subunit isoform 2
[Homo sapiens]
Length = 735
Score = 75.5 bits (184), Expect = 4e-13
Identities = 84/405 (20%), Positives = 172/405 (42%), Gaps = 63/405 (15%)
Query: 1 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI 60
M G G +D + + +RKE R+ + R +E++ ELA + N
Sbjct: 1 MEGAG-GANDKKKISSERRKE--------KSRDAARSRRSKESEVFYELAHQLPLPHNVS 51
Query: 61 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML 120
+ DK ++++ T+ +R +++ A +I++ K+ ++ L
Sbjct: 52 SHL----DKASVMRLTISYLR-VRKLLDAGDLDIEDDMKAQMNC-------------FYL 93
Query: 121 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI 180
+ALDGF V+ +G+++++S+NV +Y+ Q EL SV+ H DH E + L +
Sbjct: 94 KALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR-- 151
Query: 181 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFA--------V 232
NG G+ + +F RM G ++ + C
Sbjct: 152 -NGLVKKGK-EQNTQRSFFLRMKC----TLTSRGRTMNIKSATWKVLHCTGHIHVYDTNS 205
Query: 233 SQPKSIKEEGEDLQSCLICVARRVPMKERPVLP-SSESFTTRQDLQGKITSLDTS-TMRA 290
+QP+ ++ +CL+ + +P +P S++F +R L K + D T
Sbjct: 206 NQPQCGYKKPP--MTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELM 263
Query: 291 AMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQ 350
+P E+L+ R I +++ + + ++ + HH++ +G + YR G V +
Sbjct: 264 GYEP--EELLGRSIYEYYHALDSDHLT---KTHHDMFTKGQVTTGQYRMLAKRGGYVWVE 318
Query: 351 TKSKLIRSQTTNEPQLVISLH-----------MLHREQNVCVMNP 384
T++ +I + ++PQ ++ ++ + +Q CV+ P
Sbjct: 319 TQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKP 363
>gi|4504385 hypoxia-inducible factor 1, alpha subunit isoform 1
[Homo sapiens]
Length = 826
Score = 75.5 bits (184), Expect = 4e-13
Identities = 84/405 (20%), Positives = 172/405 (42%), Gaps = 63/405 (15%)
Query: 1 MSGMGENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDI 60
M G G +D + + +RKE R+ + R +E++ ELA + N
Sbjct: 1 MEGAG-GANDKKKISSERRKE--------KSRDAARSRRSKESEVFYELAHQLPLPHNVS 51
Query: 61 DNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMML 120
+ DK ++++ T+ +R +++ A +I++ K+ ++ L
Sbjct: 52 SHL----DKASVMRLTISYLR-VRKLLDAGDLDIEDDMKAQMNC-------------FYL 93
Query: 121 EALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSI 180
+ALDGF V+ +G+++++S+NV +Y+ Q EL SV+ H DH E + L +
Sbjct: 94 KALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHR-- 151
Query: 181 VNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFA--------V 232
NG G+ + +F RM G ++ + C
Sbjct: 152 -NGLVKKGK-EQNTQRSFFLRMKC----TLTSRGRTMNIKSATWKVLHCTGHIHVYDTNS 205
Query: 233 SQPKSIKEEGEDLQSCLICVARRVPMKERPVLP-SSESFTTRQDLQGKITSLDTS-TMRA 290
+QP+ ++ +CL+ + +P +P S++F +R L K + D T
Sbjct: 206 NQPQCGYKKPP--MTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELM 263
Query: 291 AMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQ 350
+P E+L+ R I +++ + + ++ + HH++ +G + YR G V +
Sbjct: 264 GYEP--EELLGRSIYEYYHALDSDHLT---KTHHDMFTKGQVTTGQYRMLAKRGGYVWVE 318
Query: 351 TKSKLIRSQTTNEPQLVISLH-----------MLHREQNVCVMNP 384
T++ +I + ++PQ ++ ++ + +Q CV+ P
Sbjct: 319 TQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKP 363
>gi|21614542 single-minded homolog 1 [Homo sapiens]
Length = 766
Score = 75.5 bits (184), Expect = 4e-13
Identities = 88/391 (22%), Positives = 158/391 (40%), Gaps = 43/391 (10%)
Query: 32 RNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIR-QIKEQEKAA 90
+N + RE+EN ELA+L+ + DK +I++ T ++ ++ E
Sbjct: 6 KNAARTRREKENSEFYELAKLLPLP----SAITSQLDKASIIRLTTSYLKMRVVFPEGLG 61
Query: 91 AANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYN 150
A + S + + G+ LG +L+ LDGF FVV +G ++++SE + +L +
Sbjct: 62 EAWGHSSRTSPLDNVGR------ELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLS 115
Query: 151 QEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDS 210
Q EL S+Y +H DH E L + R+ +L K
Sbjct: 116 QVELTGNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGL 175
Query: 211 EEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSC-----LICVARRVPMKE-RPVL 264
G Y+ + C + + + C L+ V +P +
Sbjct: 176 TCGG---------YKVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIK 226
Query: 265 PSSESFTTRQDLQGKITSLDTSTMRAAMKPGWE--DLVRRCIQKFHAQHEGESVSYAKRH 322
S F R L K+ LD+ R A G+E DL+ + + +H H G + +
Sbjct: 227 LHSNMFMFRASLDMKLIFLDS---RVAELTGYEPQDLIEKTL--YHHVH-GCDTFHLRCA 280
Query: 323 HHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHREQNVCVM 382
HH +L +G ++ YRF G V Q+ + ++ + ++ P ++S+ N +
Sbjct: 281 HHLLLVKGQVTTKYYRFLAKHGGWVWVQSYATIVHNSRSSRPHCIVSV-------NYVLT 333
Query: 383 NPDLTGQTMGKPLNPISSNSPAHQALCSGNP 413
+ + G + L+ IS++ PA S P
Sbjct: 334 DTEYKGLQLS--LDQISASKPAFSYTSSSTP 362
>gi|22027471 neuronal PAS domain protein 2 [Homo sapiens]
Length = 824
Score = 74.7 bits (182), Expect = 6e-13
Identities = 77/359 (21%), Positives = 150/359 (41%), Gaps = 28/359 (7%)
Query: 24 DQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQI 83
D+ + + +EK+ R+Q N I+EL+ ++ N K DK +L++ + ++
Sbjct: 7 DRAKRASRNKSEKKRRDQFNVLIKELSSMLPGNTR-------KMDKTTVLEKVIGFLQ-- 57
Query: 84 KEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNVVFVSENV 143
K E +A I ++Q+ S + + +MLEALDGF V +G++++VS+++
Sbjct: 58 KHNEVSAQTEICDIQQDWKPS----FLSNEEFTQLMLEALDGFIIAVTTDGSIIYVSDSI 113
Query: 144 TQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRML 203
T L + ++M++++ + L +H+E K L +V + F C +L
Sbjct: 114 TPLLGHLPSDVMDQNLLNFLPEQEHSEVYKILSSHMLVTDSPSPEYLKSDSDLEFYCHLL 173
Query: 204 VKPLPDSEEEGHD------NQEAHQKYETMQC----FAVSQPKSIKEEGEDLQSCLICVA 253
L E ++ N ++ + C +S+P + E + +A
Sbjct: 174 RGSLNPKEFPTYEYIKFVGNFRSYNNVPSPSCNGFDNTLSRPCRVPLGKEVCFIATVRLA 233
Query: 254 RRVPMKERPVLPSS-ESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHE 312
+KE ++ E FT+R L+ K LD +E L +H
Sbjct: 234 TPQFLKEMCIVDEPLEEFTSRHSLEWKFLFLDHRAPPIIGYLPFEVLGTSGYDYYHI--- 290
Query: 313 GESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLH 371
+ + R H +++ G S YRF + QT + Q ++P+ ++ H
Sbjct: 291 -DDLELLARCHQHLMQFGKGKSCCYRFLTKGQQWIWLQTHYYITYHQWNSKPEFIVCTH 348
>gi|40254439 endothelial PAS domain protein 1 [Homo sapiens]
Length = 870
Score = 72.4 bits (176), Expect = 3e-12
Identities = 87/396 (21%), Positives = 165/396 (41%), Gaps = 47/396 (11%)
Query: 10 DPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDK 69
+ R+ + +RKE R+ + R +E + ELA + + + DK
Sbjct: 6 EKKRSSSERRKE--------KSRDAARCRRSKETEVFYELAHELPLPHSVSSHL----DK 53
Query: 70 CAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFV 129
+I++ + +R K + N E + + + L+AL+GF V
Sbjct: 54 ASIMRLAISFLRTHKLLSSVCSENESEAEADQ------------QMDNLYLKALEGFIAV 101
Query: 130 VNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGE 189
V +G+++F+SEN+++++ Q EL S++ H DH E +NL K+ GS G+
Sbjct: 102 VTQDGDMIFLSENISKFMGLTQVELTGHSIFDFTHPCDHEEIRENLSLKN----GSGFGK 157
Query: 190 PPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCFA-------VSQPKSIKEEG 242
+ S + M +K + G ++ + C S+
Sbjct: 158 KSKDMSTERDFFMRMKCTVTN--RGRTVNLKSATWKVLHCTGQVKVYNNCPPHNSLCGYK 215
Query: 243 EDLQSCLICVARRVPMKERPVLP-SSESFTTRQDLQGKITSLDTS-TMRAAMKPGWEDLV 300
E L SCLI + + +P S++F +R + K T D T P E+L+
Sbjct: 216 EPLLSCLIIMCEPIQHPSHMDIPLDSKTFLSRHSMDMKFTYCDDRITELIGYHP--EELL 273
Query: 301 RRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQT 360
R +F+ + E+++ + H + +G S YR G V +T+ +I +
Sbjct: 274 GRSAYEFYHALDSENMT---KSHQNLCTKGQVVSGQYRMLAKHGGYVWLETQGTVIYNPR 330
Query: 361 TNEPQLVISLH--MLHREQNVCVMNPDLTGQTMGKP 394
+PQ ++ ++ + E+N V + D T +++ KP
Sbjct: 331 NLQPQCIMCVNYVLSEIEKNDVVFSMDQT-ESLFKP 365
>gi|90421311 hypoxia inducible factor 3, alpha subunit isoform c
[Homo sapiens]
Length = 669
Score = 69.3 bits (168), Expect = 3e-11
Identities = 93/415 (22%), Positives = 170/415 (40%), Gaps = 54/415 (13%)
Query: 18 KRKECPDQLGPSPKRNTEKRNREQENKYIEELAELI-FANFNDIDNFNFKPDKCAILKET 76
+R +L R+ + R QE + + +LA + FA + DK +I++ T
Sbjct: 6 QRARSTTELRKEKSRDAARSRRSQETEVLYQLAHTLPFAR-----GVSAHLDKASIMRLT 60
Query: 77 VKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLEGNV 136
+ +R AA ++V G G DA L+AL+GF V+ EG++
Sbjct: 61 ISYLRM---HRLCAAGEWNQV--------GAGGEPLDAC---YLKALEGFVMVLTAEGDM 106
Query: 137 VFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSH 196
++SENV+++L +Q EL+ S++ +H D E L P+ ++ R
Sbjct: 107 AYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTER---- 162
Query: 197 TFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCF---------AVSQPKSIKEEGEDLQS 247
F+ RM G ++ + C A + P + LQ
Sbjct: 163 CFSLRM----KSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSEPPLQ- 217
Query: 248 CLICVARRVPMKERPVLPSSE-SFTTRQDLQGKITSLDTSTMRAAMKPGW--EDLVRRCI 304
CL+ + +P P +F +R L K T D R A G+ +DL+
Sbjct: 218 CLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDD---RIAEVAGYSPDDLIGCSA 274
Query: 305 QKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEP 364
++ + ++VS + H +L +G A + YRF G + QT++ ++ +
Sbjct: 275 YEYIHALDSDAVS---KSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGGRGPQS 331
Query: 365 QLVISLHML--HREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDM 417
+ ++ +H L E+ V++ + T Q + PI +P+ + + NPG +
Sbjct: 332 ESIVCVHFLISQVEETGVVLSLEQTEQHSRR---PIQRGAPSQKD--TPNPGDSL 381
>gi|23065535 hypoxia inducible factor 3, alpha subunit isoform a
[Homo sapiens]
Length = 667
Score = 68.9 bits (167), Expect = 3e-11
Identities = 96/420 (22%), Positives = 172/420 (40%), Gaps = 62/420 (14%)
Query: 13 RAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELI-FANFNDIDNFNFKPDKCA 71
R+ T RKE R+ + R QE + + +LA + FA + DK +
Sbjct: 7 RSTTELRKE--------KSRDAARSRRSQETEVLYQLAHTLPFAR-----GVSAHLDKAS 53
Query: 72 ILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVN 131
I++ T+ +R AA ++V G G DA L+AL+GF V+
Sbjct: 54 IMRLTISYLRM---HRLCAAGEWNQV--------GAGGEPLDAC---YLKALEGFVMVLT 99
Query: 132 LEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPP 191
EG++ ++SENV+++L +Q EL+ S++ +H D E L P+ ++
Sbjct: 100 AEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQDALTPQQTLSRRKVEAPTE 159
Query: 192 RRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCF---------AVSQPKSIKEEG 242
R F+ RM G ++ + C A + P +
Sbjct: 160 R----CFSLRM----KSTLTSRGRTLNLKAATWKVLNCSGHMRAYKPPAQTSPAGSPDSE 211
Query: 243 EDLQSCLICVARRVPMKERPVLPSSE-SFTTRQDLQGKITSLDTSTMRAAMKPGW--EDL 299
LQ CL+ + +P P +F +R L K T D R A G+ +DL
Sbjct: 212 PPLQ-CLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTYCDD---RIAEVAGYSPDDL 267
Query: 300 VRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQ 359
+ ++ + ++VS + H +L +G A + YRF G + QT++ ++
Sbjct: 268 IGCSAYEYIHALDSDAVS---KSIHTLLSKGQAVTGQYRFLARSGGYLWTQTQATVVSGG 324
Query: 360 TTNEPQLVISLHML--HREQNVCVMNPDLTGQTMGKPLNPISSNSPAHQALCSGNPGQDM 417
+ + ++ +H L E+ V++ + T Q + PI +P+ + + NPG +
Sbjct: 325 RGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRR---PIQRGAPSQKD--TPNPGDSL 379
>gi|115430245 arylhydrocarbon receptor repressor [Homo sapiens]
Length = 719
Score = 68.2 bits (165), Expect = 6e-11
Identities = 49/185 (26%), Positives = 90/185 (48%), Gaps = 26/185 (14%)
Query: 17 RKRKECPDQLGPS---PKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAIL 73
RKR+ + P+ K N KR+R++ N ++ LA L+ + I K DK ++L
Sbjct: 16 RKRRRPLQKQRPAVGAEKSNPSKRHRDRLNAELDHLASLLPFPPDIIS----KLDKLSVL 71
Query: 74 KETVKQIRQ------IKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFF 127
+ +V +R ++EQ A G V++ G ++LE+L+GF
Sbjct: 72 RLSVSYLRVKSFFQVVQEQSSRQPAAGAPSPGDSCPLAGSAVLE----GRLLLESLNGFA 127
Query: 128 FVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWS 187
VV+ EG + + S + YL ++Q ++M++++Y +HV D +F + L W+
Sbjct: 128 LVVSAEGTIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQL---------HWA 178
Query: 188 GEPPR 192
+PP+
Sbjct: 179 MDPPQ 183
>gi|4827004 single-minded homolog 2 long isoform [Homo sapiens]
Length = 667
Score = 68.2 bits (165), Expect = 6e-11
Identities = 82/355 (23%), Positives = 146/355 (41%), Gaps = 36/355 (10%)
Query: 32 RNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAA 91
+N K RE+EN ELA+L+ + DK +I++ T + K A
Sbjct: 6 KNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYL-------KMRA 54
Query: 92 ANIDEVQKSDVSSTGQGVIDKDA--LGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRY 149
+ + + + G +D A LG +L+ LDGF FVV +G ++++SE + +L
Sbjct: 55 VFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGL 114
Query: 150 NQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPD 209
+Q EL S+Y +H DH E L ++ R+ +L K
Sbjct: 115 SQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAG 174
Query: 210 SEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSC-----LICVARRVPMKE-RPV 263
G Y+ + C + + + SC L+ V + +P +
Sbjct: 175 LTCSG---------YKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEI 225
Query: 264 LPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWE--DLVRRCIQKFHAQHEGESVSYAKR 321
S F R L K+ LD+ R G+E DL+ + + +H H G V + +
Sbjct: 226 KLYSNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTL--YHHVH-GCDVFHLRY 279
Query: 322 HHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHRE 376
HH +L +G ++ YR G V Q+ + ++ + ++ P ++S++ + E
Sbjct: 280 AHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTE 334
>gi|194239684 single-minded homolog 2 short isoform [Homo sapiens]
Length = 570
Score = 68.2 bits (165), Expect = 6e-11
Identities = 82/355 (23%), Positives = 146/355 (41%), Gaps = 36/355 (10%)
Query: 32 RNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQIRQIKEQEKAAA 91
+N K RE+EN ELA+L+ + DK +I++ T + K A
Sbjct: 6 KNAAKTRREKENGEFYELAKLLPLP----SAITSQLDKASIIRLTTSYL-------KMRA 54
Query: 92 ANIDEVQKSDVSSTGQGVIDKDA--LGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRY 149
+ + + + G +D A LG +L+ LDGF FVV +G ++++SE + +L
Sbjct: 55 VFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGL 114
Query: 150 NQEELMNKSVYSILHVGDHTEFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPD 209
+Q EL S+Y +H DH E L ++ R+ +L K
Sbjct: 115 SQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAG 174
Query: 210 SEEEGHDNQEAHQKYETMQCFAVSQPKSIKEEGEDLQSC-----LICVARRVPMKE-RPV 263
G Y+ + C + + + SC L+ V + +P +
Sbjct: 175 LTCSG---------YKVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEI 225
Query: 264 LPSSESFTTRQDLQGKITSLDTSTMRAAMKPGWE--DLVRRCIQKFHAQHEGESVSYAKR 321
S F R L K+ LD+ R G+E DL+ + + +H H G V + +
Sbjct: 226 KLYSNMFMFRASLDLKLIFLDS---RVTEVTGYEPQDLIEKTL--YHHVH-GCDVFHLRY 279
Query: 322 HHHEVLRQGLAFSQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVISLHMLHRE 376
HH +L +G ++ YR G V Q+ + ++ + ++ P ++S++ + E
Sbjct: 280 AHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTE 334
>gi|4502003 aryl hydrocarbon receptor [Homo sapiens]
Length = 848
Score = 67.8 bits (164), Expect = 7e-11
Identities = 73/295 (24%), Positives = 123/295 (41%), Gaps = 64/295 (21%)
Query: 4 MGENTSDPSRAETRKRKECPDQLGPSP----KRNTEKRNREQENKYIEELAELIFANFND 59
M ++++ + A ++RK + P P K N KR+R++ N ++ LA L+ D
Sbjct: 1 MNSSSANITYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFP-QD 59
Query: 60 IDNFNFKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDAL---- 115
+ N K DK ++L+ +V +R A + D KS + G + A
Sbjct: 60 VIN---KLDKLSVLRLSVSYLR--------AKSFFDVALKSSPTERNGGQDNCRAANFRE 108
Query: 116 ------GPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHT 169
G +L+AL+GF VV + V + S + YL + Q +++++SVY ++H D
Sbjct: 109 GLNLQEGEFLLQALNGFVLVVTTDALVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRA 168
Query: 170 EFVKNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQC 229
EF + L W+ P + E G +EA +T+ C
Sbjct: 169 EFQRQL---------HWALNPSQ-----------------CTESGQGIEEATGLPQTVVC 202
Query: 230 FAVSQPKSIKEEGEDL-QSCLICVARRVPMKERPVLPSSESFTTRQDLQGKITSL 283
+ P I E L + C IC + R +L +S F + QGK+ L
Sbjct: 203 Y---NPDQIPPENSPLMERCFIC-------RLRCLLDNSSGFLA-MNFQGKLKYL 246
>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
sapiens]
Length = 5537
Score = 64.3 bits (155), Expect = 8e-10
Identities = 133/580 (22%), Positives = 196/580 (33%), Gaps = 130/580 (22%)
Query: 875 PGQLGRLL---PNQNLPLDITLQSPTGAGPFPPIRNSSPYSVIPQ----PGMMG----NQ 923
P Q RLL P Q LP LQ P G PP + + P PG G N
Sbjct: 3621 PSQSPRLLTKLPGQLLP-GHGLQPPQG----PPGGQAGGLRLTPGGMALPGQPGGPFLNT 3675
Query: 924 GMIGNQGNLGNSSTGMIGNSASRPTMPSGEWAPQSSAVRVTCAATTSAMNRPVQGGMIRN 983
+ Q + G + PSG + P + A+R + R +Q R
Sbjct: 3676 ALAQQQQQQHSGGAGSLAG-------PSGGFFPGNLALRSLGPDSRLLQERQLQLQQQRM 3728
Query: 984 PAASIPMRPSSQPGQRQTLQSQVMNIGPSELEMNMGGPQYSQQQAPPNQT----APWPES 1039
A + Q Q+Q L QV Q QQQ P QT P P+
Sbjct: 3729 QLAQKLQQQQQQQQQQQHLLGQV-------------AIQQQQQQGPGVQTNQALGPKPQG 3775
Query: 1040 ILPIDQASFASQNRQPFGSSPDDLLCPHPAAESPSDEGALLDQLYLALRNFDGLEEIDRA 1099
++P SS LL + + P +L +A+ ++ A
Sbjct: 3776 LMP--------------PSSHQGLLVQQLSPQPPQGPQGMLGPAQVAVLQ----QQHPGA 3817
Query: 1100 LGIPE------LVSQSQAVDPEQFSSQDSNIMLEQKAPVFPQQYASQAQMAQGSYSPMQD 1153
LG P+ L++QS+ + Q + Q +M + QQ Q Q QGS + +
Sbjct: 3818 LG-PQGPHRQVLMTQSRVLSSPQLAQQGQGLMGHRLVTAQQQQQQQQHQQ-QGSMAGLS- 3874
Query: 1154 PNFHTMGQRPSYATLRMQPRPGLRPTGLVQNQPNQLRLQLQHRLQAQQNRQPLMNQISNV 1213
H S++ QP+ +P G +Q Q +LQ Q +LQ QQ +Q + Q +
Sbjct: 3875 ---HLQQSLMSHSG---QPKLSAQPMGSLQQLQQQQQLQQQQQLQQQQQQQ--LQQQQQL 3926
Query: 1214 SNVNLTLRPGVPTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMT 1273
L + Q Q Q+Q + Q L+Q+Q QQQQ QQ+ + LN +
Sbjct: 3927 QQQQLQQQ-----QQQQQLQQQQQQQLQQQQQQLQQQQQQQQQQFQQQQQQQQMGLLNQS 3981
Query: 1274 PSMVAP--SGMPATMSNPRIPQANAQQFPFPPNYG----------------ISQQPDPG- 1314
++++P P +P Q F P G +S + G
Sbjct: 3982 RTLLSPQQQQQQQVALGPGMPAKPLQHFSSPGALGPTLLLTGKEQNTVDPAVSSEATEGP 4041
Query: 1315 -------FTGATTPQS------------------------PLMSPRMAHTQSPMMQQSQA 1343
TTP+S P P Q P+ Q
Sbjct: 4042 STHQGGPLAIGTTPESMATEPGEVKPSLSGDSQLLLVQPQPQPQPSSLQLQPPLRLPGQQ 4101
Query: 1344 NPAYQAPSDINGWAQGNMGGNSMFSQQSPPHFGQQANTSM 1383
G + G +G S S PH Q + S+
Sbjct: 4102 QQQVSLLHTAGGGSHGQLGSGSSSEASSVPHLLAQPSVSL 4141
Score = 39.7 bits (91), Expect = 0.022
Identities = 36/139 (25%), Positives = 56/139 (40%), Gaps = 8/139 (5%)
Query: 1235 LAQRQREILNQHLRQRQMHQQQQVQQRTLMMRGQGLNMTPSMVAPSG-MPATMSNPRIPQ 1293
L+Q + E Q R R++ +QQ+Q+ TL + V P G A S+P Q
Sbjct: 2672 LSQTELEKQRQRQRLRELLIRQQIQRNTLRQEKETAAAAAGAVGPPGSWGAEPSSPAFEQ 2731
Query: 1294 ANAQQFPFPPNYGISQQPDPGFTGATTPQSPLMSPRMAHTQSPMMQQSQANPAYQAPSDI 1353
+ Q PF Q G P S L P + P + P PS +
Sbjct: 2732 LSRGQTPF-----AGTQDKSSLVG--LPPSKLSGPILGPGSFPSDDRLSRPPPPATPSSM 2784
Query: 1354 NGWAQGNMGGNSMFSQQSP 1372
+ ++ +GG+ F Q++P
Sbjct: 2785 DVNSRQLVGGSQAFYQRAP 2803
Score = 34.7 bits (78), Expect = 0.69
Identities = 63/270 (23%), Positives = 95/270 (35%), Gaps = 34/270 (12%)
Query: 1108 QSQAVDPEQFS---SQDSNIMLEQKAPVFPQQYASQAQ--MAQGSYSPMQDPNFHTMG-- 1160
+S A +P + S DS ++L Q P PQ + Q Q + Q HT G
Sbjct: 4056 ESMATEPGEVKPSLSGDSQLLLVQPQPQ-PQPSSLQLQPPLRLPGQQQQQVSLLHTAGGG 4114
Query: 1161 -----------QRPSYATLRMQPRPGL--RPTGLVQNQPNQLRLQLQHRLQAQQNRQPLM 1207
+ S L QP L +P + QN + L+ +Q QP
Sbjct: 4115 SHGQLGSGSSSEASSVPHLLAQPSVSLGDQPGSMTQNLLGPQQPMLERPMQNNTGPQPPK 4174
Query: 1208 NQISNVSNVNLTLRPGV---PTQAPINAQMLAQRQREILNQHLRQRQMHQQQQVQQRTLM 1264
S L PGV PT + AQ+ + +HL +Q Q Q + + +
Sbjct: 4175 PGPVLQSGQGL---PGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQL 4231
Query: 1265 MRGQGLNMTPSMVAPSGMPATMSNPRIPQANAQQFPFPPNYGISQQPDPGFTGATTPQSP 1324
+ Q + TP P + + Q FP P G Q+ G PQ P
Sbjct: 4232 QQSQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFP-GPQTGPLQELGAG----PRPQGP 4286
Query: 1325 --LMSPRMAHTQSPMMQQSQANPAYQAPSD 1352
L +P A + P++ P +P +
Sbjct: 4287 PRLPAPPGALSTGPVLGPVHPTPPPSSPQE 4316
>gi|11545847 neuronal PAS domain protein 3 isoform 1 [Homo sapiens]
Length = 901
Score = 63.5 bits (153), Expect = 1e-09
Identities = 80/398 (20%), Positives = 150/398 (37%), Gaps = 49/398 (12%)
Query: 11 PSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKC 70
PS + R+E L R+ + R +EN ELA+L+ DK
Sbjct: 6 PSFQQDPSRRERLQALRKEKSRDAARSRRGKENFEFYELAKLLPLPAAITSQL----DKA 61
Query: 71 AILKETVKQIRQ------------IKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPM 118
+I++ T+ ++ ++ + ++ Q+ S + + LG
Sbjct: 62 SIIRLTISYLKMRDFANQGDPPWNLRMEGPPPNTSVKGAQRRRSPSALAIEVFEAHLGSH 121
Query: 119 MLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKNL--- 175
+L++LDGF F +N EG +++SE V+ YL +Q EL SV+ +H GDH E + L
Sbjct: 122 ILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQLGMK 181
Query: 176 LPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEE--GHDNQEAHQKYETMQCFAVS 233
LP + E ++ + + +P+ + DN + M+
Sbjct: 182 LPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKSTLTK 241
Query: 234 QPKSIKEEGEDLQSCLICVARRVPMKERPVLPSS-----------------------ESF 270
+ IK G + + RV + +PS F
Sbjct: 242 RGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRIDCHMF 301
Query: 271 TTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQG 330
TR ++ I + + + +RC HA E V + H ++L +G
Sbjct: 302 VTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHA----EDVEGIRHSHLDLLNKG 357
Query: 331 LAFSQIYRFSLSDGTLVAAQTKSKL-IRSQTTNEPQLV 367
++ YR+ +G + Q+ + + I ++ NE ++
Sbjct: 358 QCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNII 395
>gi|90421316 hypoxia inducible factor 3, alpha subunit isoform b
[Homo sapiens]
Length = 613
Score = 63.5 bits (153), Expect = 1e-09
Identities = 72/319 (22%), Positives = 134/319 (42%), Gaps = 34/319 (10%)
Query: 113 DALGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFV 172
+ L L+AL+GF V+ EG++ ++SENV+++L +Q EL+ S++ +H D E
Sbjct: 27 EPLDACYLKALEGFVMVLTAEGDMAYLSENVSKHLGLSQLELIGHSIFDFIHPCDQEELQ 86
Query: 173 KNLLPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEEGHDNQEAHQKYETMQCF-- 230
L P+ ++ R F+ RM G ++ + C
Sbjct: 87 DALTPQQTLSRRKVEAPTER----CFSLRM----KSTLTSRGRTLNLKAATWKVLNCSGH 138
Query: 231 -------AVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSSE-SFTTRQDLQGKITS 282
A + P + LQ CL+ + +P P +F +R L K T
Sbjct: 139 MRAYKPPAQTSPAGSPDSEPPLQ-CLVLICEAIPHPGSLEPPLGRGAFLSRHSLDMKFTY 197
Query: 283 LDTSTMRAAMKPGW--EDLVRRCIQKFHAQHEGESVSYAKRHHHEVLRQGLAFSQIYRFS 340
D R A G+ +DL+ ++ + ++VS + H +L +G A + YRF
Sbjct: 198 CDD---RIAEVAGYSPDDLIGCSAYEYIHALDSDAVS---KSIHTLLSKGQAVTGQYRFL 251
Query: 341 LSDGTLVAAQTKSKLIRSQTTNEPQLVISLHML--HREQNVCVMNPDLTGQTMGKPLNPI 398
G + QT++ ++ + + ++ +H L E+ V++ + T Q + PI
Sbjct: 252 ARSGGYLWTQTQATVVSGGRGPQSESIVCVHFLISQVEETGVVLSLEQTEQHSRR---PI 308
Query: 399 SSNSPAHQALCSGNPGQDM 417
+P+ + + NPG +
Sbjct: 309 QRGAPSQKD--TPNPGDSL 325
>gi|68303555 aryl hydrocarbon receptor nuclear translocator 2 [Homo
sapiens]
Length = 717
Score = 61.2 bits (147), Expect = 7e-09
Identities = 128/597 (21%), Positives = 225/597 (37%), Gaps = 113/597 (18%)
Query: 21 ECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCAILKETVKQI 80
E P + E+R R + +YI EL++++ KPDK IL+ V +
Sbjct: 58 EGPSKFSRENHSEIERRRRNKMTQYITELSDMV----PTCSALARKPDKLTILRMAVSHM 113
Query: 81 RQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVNLE-GNVVFV 139
+ ++ KS + + + L ++LEA DGF FVV E G V++V
Sbjct: 114 KSMRGTGN----------KSTDGAYKPSFLTEQELKHLILEAADGFLFVVAAETGRVIYV 163
Query: 140 SENVTQYLRYNQEELMNKSVYSILHVGD--------------HTEFVKNLLPKSIVNGGS 185
S++VT L Q E ++Y +H D T + +L ++ G
Sbjct: 164 SDSVTPVLNQPQSEWFGSTLYEQVHPDDVEKLREQLCTSENSMTGRILDLKTGTVKKEGQ 223
Query: 186 WSGEPPRRNS-HTFNCRMLVKPLP---------DSEEEGHDN-----QEAHQKYETMQC- 229
S S +F CRM P + + N +E +Y + C
Sbjct: 224 QSSMRMCMGSRRSFICRMRCGNAPLDHLPLNRITTMRKRFRNGLGPVKEGEAQYAVVHCT 283
Query: 230 --------FAVSQPKSIKEEGEDLQSCLICVARRVPMKERPV------LPSSESFTTRQD 275
++ P+ + G+ + CL+ + R+ + PV + F +R +
Sbjct: 284 GYIKAWPPAGMTIPEEDADVGQGSKYCLVAIG-RLQVTSSPVCMDMNGMSVPTEFLSRHN 342
Query: 276 LQGKITSLDTSTMRA-AMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEVLR-QGLAF 333
G IT +D + +P +DL+ + I +F E S+ + +V++ +G
Sbjct: 343 SDGIITFVDPRCISVIGYQP--QDLLGKDILEF---CHPEDQSHLRESFQQVVKLKGQVL 397
Query: 334 SQIYRFSLSDGTLVAAQTKSKLIRSQTTNEPQLVI----SLHMLHREQ------------ 377
S +YRF + + +T S ++ ++E + +I ++ L ++Q
Sbjct: 398 SVMYRFRTKNREWMLIRTSSFTFQNPYSDEIEYIICTNTNVKQLQQQQAELEVHQRDGLS 457
Query: 378 -----NVCVMNPDLTGQTMGKPLNPISS-----NSPAHQALCSGNPGQDMTLSSNINFPI 427
V V N GK + + P + +G + + S+ +
Sbjct: 458 SYDLSQVPVPNLPAGVHEAGKSVEKADAIFSQERDPRFAEMFAGISASEKKMMSSASAAG 517
Query: 428 NGPKEQMG--MPMGRFGG--SGGMNHVSG---MQATTPQGSNYALKMNSPSQSSPGMN-- 478
G P G G S + HV G +Q+++ G N + +QS
Sbjct: 518 TQQIYSQGSPFPSGHSGKAFSSSVVHVPGVNDIQSSSSTGQNMSQISRQLNQSQVAWTGS 577
Query: 479 ----PGQPTSMLSPRHRMSP-GVAGSPRIP--PSQFSPAGSLHSPVGVCSSTGNSHS 528
PGQ S + + SP G+ S P PS +SP L SP S +GN++S
Sbjct: 578 RPPFPGQQIPSQSSKTQSSPFGIGTSHTYPADPSSYSP---LSSP-ATSSPSGNAYS 630
>gi|41281831 neuronal PAS domain protein 3 isoform 2 [Homo sapiens]
Length = 920
Score = 60.1 bits (144), Expect = 2e-08
Identities = 61/282 (21%), Positives = 110/282 (39%), Gaps = 33/282 (11%)
Query: 115 LGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKN 174
LG +L++LDGF F +N EG +++SE V+ YL +Q EL SV+ +H GDH E +
Sbjct: 137 LGSHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVELTGSSVFDYVHPGDHVEMAEQ 196
Query: 175 L---LPKSIVNGGSWSGEPPRRNSHTFNCRMLVKPLPDSEEE--GHDNQEAHQKYETMQC 229
L LP + E ++ + + +P+ + DN + M+
Sbjct: 197 LGMKLPPGRGLLSQGTAEDGASSASSSSQSETPEPVESTSPSLLTTDNTLERSFFIRMKS 256
Query: 230 FAVSQPKSIKEEGEDLQSCLICVARRVPMKERPVLPSS---------------------- 267
+ IK G + + RV + +PS
Sbjct: 257 TLTKRGVHIKSSGYKVIHITGRLRLRVSLSHGRTVPSQIMGLVVVAHALPPPTINEVRID 316
Query: 268 -ESFTTRQDLQGKITSLDTSTMRAAMKPGWEDLVRRCIQKFHAQHEGESVSYAKRHHHEV 326
F TR ++ I + + + +RC HA E V + H ++
Sbjct: 317 CHMFVTRVNMDLNIIYCENRISDYMDLTPVDIVGKRCYHFIHA----EDVEGIRHSHLDL 372
Query: 327 LRQGLAFSQIYRFSLSDGTLVAAQTKSKL-IRSQTTNEPQLV 367
L +G ++ YR+ +G + Q+ + + I ++ NE ++
Sbjct: 373 LNKGQCVTKYYRWMQKNGGYIWIQSSATIAINAKNANEKNII 414
>gi|22027482 neuronal PAS domain protein 1 [Homo sapiens]
Length = 590
Score = 58.9 bits (141), Expect = 3e-08
Identities = 26/61 (42%), Positives = 41/61 (67%)
Query: 115 LGPMMLEALDGFFFVVNLEGNVVFVSENVTQYLRYNQEELMNKSVYSILHVGDHTEFVKN 174
LG +L++LDGF F +N EG +++SE V+ YL +Q E+ SV+ +H GDH+E ++
Sbjct: 138 LGGHILQSLDGFVFALNQEGKFLYISETVSIYLGLSQVEMTGSSVFDYIHPGDHSEVLEQ 197
Query: 175 L 175
L
Sbjct: 198 L 198
>gi|30795242 aryl hydrocarbon receptor nuclear translocator isoform
3 [Homo sapiens]
Length = 774
Score = 56.6 bits (135), Expect = 2e-07
Identities = 44/164 (26%), Positives = 74/164 (45%), Gaps = 15/164 (9%)
Query: 5 GENTSDPSRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFN 64
GE S R + + ++ E+R R + YI EL++++
Sbjct: 53 GEGNSKFLRCDDDQMSNDKERFARENHSEIERRRRNKMTAYITELSDMV----PTCSALA 108
Query: 65 FKPDKCAILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALD 124
KPDK IL+ V ++ ++ + +D S + D++ L ++LEA D
Sbjct: 109 RKPDKLTILRMAVSHMKSLRGTGNTS---------TDGSYKPSFLTDQE-LKHLILEAAD 158
Query: 125 GFFFVVNLE-GNVVFVSENVTQYLRYNQEELMNKSVYSILHVGD 167
GF F+V+ E G VV+VS++VT L Q E ++Y +H D
Sbjct: 159 GFLFIVSCETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDD 202
>gi|30795240 aryl hydrocarbon receptor nuclear translocator isoform
2 [Homo sapiens]
Length = 328
Score = 56.2 bits (134), Expect = 2e-07
Identities = 42/157 (26%), Positives = 74/157 (47%), Gaps = 15/157 (9%)
Query: 12 SRAETRKRKECPDQLGPSPKRNTEKRNREQENKYIEELAELIFANFNDIDNFNFKPDKCA 71
+R++ + ++L E+R R + YI EL++++ KPDK
Sbjct: 75 ARSDDEQSSADKERLARENHSEIERRRRNKMTAYITELSDMV----PTCSALARKPDKLT 130
Query: 72 ILKETVKQIRQIKEQEKAAAANIDEVQKSDVSSTGQGVIDKDALGPMMLEALDGFFFVVN 131
IL+ V ++ ++ + +D S + D++ L ++LEA DGF F+V+
Sbjct: 131 ILRMAVSHMKSLRGTGNTS---------TDGSYKPSFLTDQE-LKHLILEAADGFLFIVS 180
Query: 132 LE-GNVVFVSENVTQYLRYNQEELMNKSVYSILHVGD 167
E G VV+VS++VT L Q E ++Y +H D
Sbjct: 181 CETGRVVYVSDSVTPVLNQPQSEWFGSTLYDQVHPDD 217
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.310 0.127 0.365
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 63,646,481
Number of Sequences: 37866
Number of extensions: 3445958
Number of successful extensions: 14698
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 53
Number of HSP's successfully gapped in prelim test: 460
Number of HSP's that attempted gapping in prelim test: 11937
Number of HSP's gapped (non-prelim): 2287
length of query: 1464
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1349
effective length of database: 13,892,928
effective search space: 18741559872
effective search space used: 18741559872
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.