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Search of human proteins with 57242759
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
(531 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 1100 0.0
gi|4557445 regulator of chromosome condensation and BTB domain c... 791 0.0
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 152 6e-37
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 152 6e-37
gi|7657152 hect domain and RLD 3 [Homo sapiens] 147 2e-35
gi|126032348 hect domain and RLD 2 [Homo sapiens] 145 9e-35
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 140 4e-33
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 131 1e-30
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 131 1e-30
gi|110825982 hect domain and RLD 5 [Homo sapiens] 127 2e-29
gi|61563742 hect domain and RLD 6 [Homo sapiens] 125 1e-28
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 113 4e-25
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 113 4e-25
gi|6912330 deafness locus associated putative guanine nucleotide... 103 5e-22
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 102 9e-22
gi|222136641 NIMA-related kinase 9 [Homo sapiens] 99 1e-20
gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo ... 93 7e-19
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 89 8e-18
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 89 8e-18
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 89 8e-18
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 89 8e-18
gi|114796640 regulator of chromosome condensation 1 [Homo sapiens] 89 8e-18
gi|114796648 regulator of chromosome condensation 1 [Homo sapiens] 89 8e-18
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 86 8e-17
gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo... 86 8e-17
gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo... 86 8e-17
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 86 1e-16
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 84 3e-16
gi|209364523 alsin isoform 2 [Homo sapiens] 82 9e-16
gi|40316935 alsin isoform 1 [Homo sapiens] 82 9e-16
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 1100 bits (2844), Expect = 0.0
Identities = 531/531 (100%), Positives = 531/531 (100%)
Query: 1 MVDVGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ 60
MVDVGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ
Sbjct: 1 MVDVGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ 60
Query: 61 STLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQ 120
STLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQ
Sbjct: 61 STLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQ 120
Query: 121 VCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHI 180
VCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHI
Sbjct: 121 VCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHI 180
Query: 181 KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVC 240
KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVC
Sbjct: 181 KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVC 240
Query: 241 GYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAA 300
GYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAA
Sbjct: 241 GYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAA 300
Query: 301 KTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESL 360
KTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESL
Sbjct: 301 KTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESL 360
Query: 361 KKEFDSPETADLKFRIDGKYIHVHKAVLKIRCEHFRSMFQSYWNEDMKEVIEIDQFSYPV 420
KKEFDSPETADLKFRIDGKYIHVHKAVLKIRCEHFRSMFQSYWNEDMKEVIEIDQFSYPV
Sbjct: 361 KKEFDSPETADLKFRIDGKYIHVHKAVLKIRCEHFRSMFQSYWNEDMKEVIEIDQFSYPV 420
Query: 421 YRAFLQYLYTDTVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRGITVENAFSLFSAAV 480
YRAFLQYLYTDTVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRGITVENAFSLFSAAV
Sbjct: 421 YRAFLQYLYTDTVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRGITVENAFSLFSAAV 480
Query: 481 RYDAEDLEEFCFKFCINHLTEVTQTAAFWQMDGPLLKEFIAKASKCGAFKN 531
RYDAEDLEEFCFKFCINHLTEVTQTAAFWQMDGPLLKEFIAKASKCGAFKN
Sbjct: 481 RYDAEDLEEFCFKFCINHLTEVTQTAAFWQMDGPLLKEFIAKASKCGAFKN 531
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 791 bits (2043), Expect = 0.0
Identities = 374/531 (70%), Positives = 439/531 (82%), Gaps = 4/531 (0%)
Query: 1 MVDVGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ 60
M+DVGKWPIF+L S +E+ IR+ACVFG++ +E LY T NDE+FV G N CLG GD Q
Sbjct: 25 MLDVGKWPIFSLCSEEELQLIRQACVFGSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQ 84
Query: 61 STLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQ 120
ST+ P++L+ L GKKI LSYGSGPH++L+T +G V+ WGHN YSQLGNGTTN G+ P
Sbjct: 85 STIEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCH 144
Query: 121 VCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHI 180
+ TNL KQV+EVACGS+HS+ L +DGEVFAWGYNN GQVGSGST NQP PR+VT CL
Sbjct: 145 ISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQN 204
Query: 181 KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVC 240
K VV IACGQ MAV+D GEVY WGYNGNGQLGLGN+GNQ TP RVAAL + V ++ C
Sbjct: 205 KVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVAC 264
Query: 241 GYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAA 300
GYAHTL LTDEG +YAWGAN+YGQLGTGNK+N P + VEK+R++EIAACHS HTSAA
Sbjct: 265 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAACHSTHTSAA 324
Query: 301 KTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESL 360
KTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAV+WRLLSVE +D LTVAESL
Sbjct: 325 KTQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVTWRLLSVEPDDHLTVAESL 384
Query: 361 KKEFDSPETADLKFRIDGKYIHVHKAVLKIRCEHFRSMFQSYWNEDMKEVIEIDQFSYPV 420
K+EFD+P+TADLKF +DGKYI+ HK +LKIRCEHFRS + NED +++E+ +FSYPV
Sbjct: 385 KREFDNPDTADLKFLVDGKYIYAHKVLLKIRCEHFRSSLED--NED--DIVEMSEFSYPV 440
Query: 421 YRAFLQYLYTDTVDLPPEDAIGLLDLATSYCENRLKKLCQHIIKRGITVENAFSLFSAAV 480
YRAFL+YLYTD++ L PE+A+GLLDLAT Y ENRLKKLCQ IK+GI ENA +L SAAV
Sbjct: 441 YRAFLEYLYTDSISLSPEEAVGLLDLATFYRENRLKKLCQQTIKQGICEENAIALLSAAV 500
Query: 481 RYDAEDLEEFCFKFCINHLTEVTQTAAFWQMDGPLLKEFIAKASKCGAFKN 531
+YDA+DLEEFCF+FCINHLT VTQT+ F +MD LLK FI+KAS+ GAFKN
Sbjct: 501 KYDAQDLEEFCFRFCINHLTVVTQTSGFAEMDHDLLKNFISKASRVGAFKN 551
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 152 bits (385), Expect = 6e-37
Identities = 93/284 (32%), Positives = 144/284 (50%), Gaps = 3/284 (1%)
Query: 28 GTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHV 87
G ++V D+ V+ G N LG +S P+++ L + I ++S G H
Sbjct: 40 GCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVALDAQNIVAVSCGEA-HT 96
Query: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADG 147
L + G VYAWG + QLG + + I + +L Q+V+VACG +HS+AL+
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKAS 156
Query: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207
EVF WG N GQ+G G+ + T ++ L + +A G S + +G ++GWG
Sbjct: 157 EVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216
Query: 208 NGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267
N GQLGL + ++ P + +L S + I CG HT ALT EG ++ +GA YGQLG
Sbjct: 217 NKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276
Query: 268 GNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
+ ++ ++P + +V AC HTSA G +Y +G
Sbjct: 277 NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320
Score = 134 bits (336), Expect = 3e-31
Identities = 83/266 (31%), Positives = 134/266 (50%), Gaps = 6/266 (2%)
Query: 15 PQEIASIRKACVFGTSASEA--LYVTDNDEVFVFGLNYSNCLG-TGDNQSTLVPKKLEGL 71
P+++ ++ + S EA L + D +V+ +GL+ LG G + VP+ ++ L
Sbjct: 75 PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
Query: 72 CGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVV 131
+I ++ G H L ++ V+ WG N Y QLG GT + Q+ +LL +
Sbjct: 135 SDIQIVQVACGYY-HSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFM 193
Query: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQT 191
+VA G HS L G +F WG N GQ+G ++ P + + L +++V I CG+
Sbjct: 194 QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKS-LRSQKIVYICCGED 252
Query: 192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALT-D 250
+ A+ G V+ +G G GQLG + +++ P +V L V +I CG HT A
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPS 312
Query: 251 EGLLYAWGANTYGQLGTGNKNNLLSP 276
G +Y++G GQLGTG+ +N SP
Sbjct: 313 SGRIYSFGLGGNGQLGTGSTSNRKSP 338
Score = 116 bits (291), Expect = 4e-26
Identities = 64/216 (29%), Positives = 110/216 (50%), Gaps = 5/216 (2%)
Query: 99 WGHNGYSQLGNGTTNQGIAPVQVCTNLLI-KQVVEVACGSHHSMALAADGEVFAWGYNNC 157
WG+ + QLG G ++ I ++ I K+V +V CG H++ + DG V+ G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 158 GQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGL-G 216
GQ+G + +P + L + +V ++CG+ ++A+ D G+VY WG + +GQLGL G
Sbjct: 64 GQLGHEKSRKKP---EQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 217 NNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSP 276
+ P + +L + + Q+ CGY H+LAL+ ++ WG N YGQLG G +
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 277 AHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312
++ + + S T G ++ WG+
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216
Score = 110 bits (274), Expect = 4e-24
Identities = 73/216 (33%), Positives = 110/216 (50%), Gaps = 9/216 (4%)
Query: 14 SPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG-DNQSTLVPKKLEGLC 72
S +I ++ AC + S L ++ EVF +G N LG G D + P+ L+ L
Sbjct: 133 SLSDIQIVQVACGYYHS----LALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL 188
Query: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE 132
G ++ G G H + T G ++ WG N + QLG N P + +L +++V
Sbjct: 189 GIPFMQVAAG-GAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP-NLLKSLRSQKIVY 246
Query: 133 VACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACG-QT 191
+ CG H+ AL +G VF +G GQ+G ST+++ PRKV + V IACG Q
Sbjct: 247 ICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMG-SIVTEIACGRQH 305
Query: 192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRV 227
+S V +G +Y +G GNGQLG G+ N+ +P V
Sbjct: 306 TSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTV 341
Score = 38.5 bits (88), Expect = 0.015
Identities = 24/88 (27%), Positives = 37/88 (42%)
Query: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
+T VF FG LG + P+K+ L G + ++ G G +
Sbjct: 257 LTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRI 316
Query: 97 YAWGHNGYSQLGNGTTNQGIAPVQVCTN 124
Y++G G QLG G+T+ +P V N
Sbjct: 317 YSFGLGGNGQLGTGSTSNRKSPFTVKGN 344
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 152 bits (385), Expect = 6e-37
Identities = 93/284 (32%), Positives = 144/284 (50%), Gaps = 3/284 (1%)
Query: 28 GTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHV 87
G ++V D+ V+ G N LG +S P+++ L + I ++S G H
Sbjct: 40 GCGLRHTVFVLDDGTVYTCGCNDLGQLG--HEKSRKKPEQVVALDAQNIVAVSCGEA-HT 96
Query: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADG 147
L + G VYAWG + QLG + + I + +L Q+V+VACG +HS+AL+
Sbjct: 97 LALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKAS 156
Query: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207
EVF WG N GQ+G G+ + T ++ L + +A G S + +G ++GWG
Sbjct: 157 EVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216
Query: 208 NGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267
N GQLGL + ++ P + +L S + I CG HT ALT EG ++ +GA YGQLG
Sbjct: 217 NKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGH 276
Query: 268 GNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
+ ++ ++P + +V AC HTSA G +Y +G
Sbjct: 277 NSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFG 320
Score = 134 bits (336), Expect = 3e-31
Identities = 83/266 (31%), Positives = 134/266 (50%), Gaps = 6/266 (2%)
Query: 15 PQEIASIRKACVFGTSASEA--LYVTDNDEVFVFGLNYSNCLG-TGDNQSTLVPKKLEGL 71
P+++ ++ + S EA L + D +V+ +GL+ LG G + VP+ ++ L
Sbjct: 75 PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
Query: 72 CGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVV 131
+I ++ G H L ++ V+ WG N Y QLG GT + Q+ +LL +
Sbjct: 135 SDIQIVQVACGYY-HSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFM 193
Query: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQT 191
+VA G HS L G +F WG N GQ+G ++ P + + L +++V I CG+
Sbjct: 194 QVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKS-LRSQKIVYICCGED 252
Query: 192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALT-D 250
+ A+ G V+ +G G GQLG + +++ P +V L V +I CG HT A
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPS 312
Query: 251 EGLLYAWGANTYGQLGTGNKNNLLSP 276
G +Y++G GQLGTG+ +N SP
Sbjct: 313 SGRIYSFGLGGNGQLGTGSTSNRKSP 338
Score = 116 bits (291), Expect = 4e-26
Identities = 64/216 (29%), Positives = 110/216 (50%), Gaps = 5/216 (2%)
Query: 99 WGHNGYSQLGNGTTNQGIAPVQVCTNLLI-KQVVEVACGSHHSMALAADGEVFAWGYNNC 157
WG+ + QLG G ++ I ++ I K+V +V CG H++ + DG V+ G N+
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 158 GQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGL-G 216
GQ+G + +P + L + +V ++CG+ ++A+ D G+VY WG + +GQLGL G
Sbjct: 64 GQLGHEKSRKKP---EQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVG 120
Query: 217 NNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSP 276
+ P + +L + + Q+ CGY H+LAL+ ++ WG N YGQLG G +
Sbjct: 121 SEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS 180
Query: 277 AHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312
++ + + S T G ++ WG+
Sbjct: 181 PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGR 216
Score = 110 bits (274), Expect = 4e-24
Identities = 73/216 (33%), Positives = 110/216 (50%), Gaps = 9/216 (4%)
Query: 14 SPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG-DNQSTLVPKKLEGLC 72
S +I ++ AC + S L ++ EVF +G N LG G D + P+ L+ L
Sbjct: 133 SLSDIQIVQVACGYYHS----LALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL 188
Query: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE 132
G ++ G G H + T G ++ WG N + QLG N P + +L +++V
Sbjct: 189 GIPFMQVAAG-GAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP-NLLKSLRSQKIVY 246
Query: 133 VACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACG-QT 191
+ CG H+ AL +G VF +G GQ+G ST+++ PRKV + V IACG Q
Sbjct: 247 ICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMG-SIVTEIACGRQH 305
Query: 192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRV 227
+S V +G +Y +G GNGQLG G+ N+ +P V
Sbjct: 306 TSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTV 341
Score = 38.5 bits (88), Expect = 0.015
Identities = 24/88 (27%), Positives = 37/88 (42%)
Query: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
+T VF FG LG + P+K+ L G + ++ G G +
Sbjct: 257 LTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRI 316
Query: 97 YAWGHNGYSQLGNGTTNQGIAPVQVCTN 124
Y++G G QLG G+T+ +P V N
Sbjct: 317 YSFGLGGNGQLGTGSTSNRKSPFTVKGN 344
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 147 bits (371), Expect = 2e-35
Identities = 92/287 (32%), Positives = 152/287 (52%), Gaps = 6/287 (2%)
Query: 32 SEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLST 91
+ ++++ ++ EV+ GLN LG + P+++ L + I ++ G H L +
Sbjct: 44 NHSVFLLEDGEVYTCGLNTKGQLG--HEREGNKPEQIGALADQHIIHVACGES-HSLALS 100
Query: 92 EDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFA 151
+ G +++WG QLG TT +A ++ L + +++V+CG+ H +ALAADG+ F
Sbjct: 101 DRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFT 160
Query: 152 WGYNNCGQVGSGST-ANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGN 210
WG N+ GQ+G G +Q +P++V + I + +A G S A+ +G V+GWG N
Sbjct: 161 WGKNSHGQLGLGKEFPSQASPQRVRSLEGIP-LAQVAAGGAHSFALSLSGAVFGWGMNNA 219
Query: 211 GQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNK 270
GQLGL + ++ +P V L + V I CG HT LT G ++ +GA + GQLG +
Sbjct: 220 GQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSM 279
Query: 271 NNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG-QCRGQ 316
N+ ++P ++ V AC HT A G +Y +G RGQ
Sbjct: 280 NDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQ 326
Score = 142 bits (357), Expect = 1e-33
Identities = 81/246 (32%), Positives = 137/246 (55%), Gaps = 10/246 (4%)
Query: 71 LCG----KKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126
+CG + +K ++ G G H + EDG VY G N QLG+ +G P Q+ L
Sbjct: 27 VCGFISDRSVKEVACG-GNHSVFLLEDGEVYTCGLNTKGQLGH--EREGNKPEQIGA-LA 82
Query: 127 IKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGI 186
+ ++ VACG HS+AL+ G++F+WG + GQ+G +T + ++ L+ + ++ +
Sbjct: 83 DQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQV 142
Query: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHSVCVNQIVCGYAHT 245
+CG +A+ +G+ + WG N +GQLGLG +Q +P RV +L + + Q+ G AH+
Sbjct: 143 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHS 202
Query: 246 LALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGG 305
AL+ G ++ WG N GQLG ++ + SP H+ + + + V +C HT A T+ G
Sbjct: 203 FALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHT-AVLTKSG 261
Query: 306 HVYMWG 311
V+ +G
Sbjct: 262 GVFTFG 267
Score = 135 bits (340), Expect = 9e-32
Identities = 88/269 (32%), Positives = 136/269 (50%), Gaps = 6/269 (2%)
Query: 15 PQEIASIRKACVFGTSASEA--LYVTDNDEVFVFGLNYSNCLGTGDNQ-STLVPKKLEGL 71
P++I ++ + + E+ L ++D ++F +G LG + S VP+ ++ L
Sbjct: 75 PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKL 134
Query: 72 CGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVV 131
+ I +S G+ H L DG + WG N + QLG G A Q +L +
Sbjct: 135 NQQTILQVSCGNW-HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLA 193
Query: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQT 191
+VA G HS AL+ G VF WG NN GQ+G ++ +P V L ++VV I+CG+
Sbjct: 194 QVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHV-KLLRTQKVVYISCGEE 252
Query: 192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALT-D 250
+ + +G V+ +G GQLG + +++ P RV L V QI CG HTLA
Sbjct: 253 HTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPS 312
Query: 251 EGLLYAWGANTYGQLGTGNKNNLLSPAHI 279
GL+YA+G GQLGTG+ N+ P+ +
Sbjct: 313 SGLIYAFGCGARGQLGTGHTCNVKCPSPV 341
Score = 125 bits (314), Expect = 1e-28
Identities = 76/216 (35%), Positives = 114/216 (52%), Gaps = 7/216 (3%)
Query: 99 WGHNGYSQLGNGTTNQGI-APVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNC 157
WG+ Q G T QGI A QVC + + V EVACG +HS+ L DGEV+ G N
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 158 GQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGN 217
GQ+G N+P + L + ++ +ACG++ S+A+ D G+++ WG +GQLGL
Sbjct: 64 GQLGHEREGNKP---EQIGALADQHIIHVACGESHSLALSDRGQLFSWGAGSDGQLGLMT 120
Query: 218 NGNQL-TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNK-NNLLS 275
+ + P + L+ + Q+ CG H LAL +G + WG N++GQLG G + + S
Sbjct: 121 TEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQAS 180
Query: 276 PAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
P + + + A AH S A + G V+ WG
Sbjct: 181 PQRVRSLEGIPLAQVAAGGAH-SFALSLSGAVFGWG 215
Score = 37.7 bits (86), Expect = 0.026
Identities = 26/101 (25%), Positives = 42/101 (41%), Gaps = 2/101 (1%)
Query: 14 SPQEIASIRKACVFGTSASE--ALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGL 71
SP + +R V S E +T + VF FG LG + P+++ L
Sbjct: 232 SPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLEL 291
Query: 72 CGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTT 112
G ++ ++ G + G++YA+G QLG G T
Sbjct: 292 MGSEVTQIACGRQHTLAFVPSSGLIYAFGCGARGQLGTGHT 332
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 145 bits (366), Expect = 9e-35
Identities = 103/283 (36%), Positives = 141/283 (49%), Gaps = 15/283 (5%)
Query: 38 TDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVY 97
T +VFV+GLN + LG VP E L + ++ GS + T +G VY
Sbjct: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGS-KSLFAVTVEGKVY 3014
Query: 98 AWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE---VACGSHHSMALAADGEVFAWGY 154
A G +LG G ++ G P+ L VV+ V G H+ AL DG+VF+WG
Sbjct: 3015 ACGEATNGRLGLGISS-GTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGE 3073
Query: 155 NNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLG 214
+ G++G S N PR + L KR+ IACG + S A+ +GE+Y WG G+LG
Sbjct: 3074 GDDGKLGHFSRMNCDKPRLI-EALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLG 3132
Query: 215 LGNNGNQLTPVRVAALHSVCVNQIVCGY--AHTLALTDEGLLYAWGANTYGQLGTGNKNN 272
G+N QL P V L V Q+ CG A TLALTDEGL+++WG +G+LG G
Sbjct: 3133 HGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEG 3192
Query: 273 LLSPAHIMVEKERVVEIAACH---SAHTSAAKTQGGHVYMWGQ 312
P +I ER+ C A S A T+ G V+ WG+
Sbjct: 3193 CNIPQNI----ERLNGQGVCQIECGAQFSLALTKSGVVWTWGK 3231
Score = 141 bits (356), Expect = 1e-33
Identities = 87/266 (32%), Positives = 142/266 (53%), Gaps = 13/266 (4%)
Query: 59 NQSTLVPKKLEGLCGKKI-KSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIA 117
N TL P+ ++GL + I K ++ G H L G VY+WG +LG+G T
Sbjct: 478 NSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEE 537
Query: 118 PVQVCT---NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKV 174
P + K VV +ACGS +S A+ A+GE++ WG N G++G GS+ ++ P V
Sbjct: 538 PKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLV 597
Query: 175 TNCLHIKRVVGIACGQ--TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHS 232
+K V+ +ACG ++AV +NG+V+ WG G+LG G + TP + L
Sbjct: 598 AGLKGLK-VIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQD 656
Query: 233 VCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIM-VEKERVVEIAA 291
+ V ++ CG ++ALT +G +Y+WG +LG G + ++ P + ++ ++V+++AA
Sbjct: 657 LDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAA 716
Query: 292 CHSAHTSAAKTQGGHVYMWG---QCR 314
S H A T+ V+ WG QC+
Sbjct: 717 -GSTH-CLALTEDSEVHSWGSNDQCQ 740
Score = 139 bits (349), Expect = 8e-33
Identities = 90/300 (30%), Positives = 150/300 (50%), Gaps = 9/300 (3%)
Query: 16 QEIASIRKACVFGTSASEALY-VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGK 74
+ +A++R + G + L+ VT + +++ G LG G +S P LE +
Sbjct: 3980 EALATLRPVQLIG--GEQTLFAVTADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHV 4037
Query: 75 KIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEV 133
IK ++ SG H L + +G VY+WG +LG+G + P +V +L +VV+V
Sbjct: 4038 FIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRP-RVIESLRGIEVVDV 4096
Query: 134 ACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQ--T 191
A G HS + A G+++ WG G++G + +Q P K+ L RVV IACG
Sbjct: 4097 AAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKP-KLVEALQGHRVVDIACGSGDA 4155
Query: 192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
++ + D+ V+ WG G+LG G + P+++ +L + V ++ CG ++ALT
Sbjct: 4156 QTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKS 4215
Query: 252 GLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
G +Y WG Y +LG G+ +++ P + + + V A S H T+ G VY WG
Sbjct: 4216 GAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCC-TEDGEVYTWG 4274
Score = 136 bits (343), Expect = 4e-32
Identities = 89/286 (31%), Positives = 146/286 (51%), Gaps = 10/286 (3%)
Query: 32 SEALY-VTDNDEVFVFGLNYSNCLGTGDNQSTL-VPKKLEGLCGKKIKSLS-YGSGPHVL 88
S++L+ VT +V+ G + LG G + T+ +P+++ L +K ++ + G H
Sbjct: 3001 SKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHAT 3060
Query: 89 LSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGE 148
T DG V++WG +LG+ + P ++ L K++ ++ACGS HS AL + GE
Sbjct: 3061 ALTVDGKVFSWGEGDDGKLGHFSRMNCDKP-RLIEALKTKRIRDIACGSSHSAALTSSGE 3119
Query: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQ--TSSMAVLDNGEVYGWG 206
++ WG G++G G Q P+ V L RV+ +ACG ++A+ D G V+ WG
Sbjct: 3120 LYTWGLGEYGRLGHGDNTTQLKPKMVKVLLG-HRVIQVACGSRDAQTLALTDEGLVFSWG 3178
Query: 207 YNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266
G+LG G + P + L+ V QI CG +LALT G+++ WG Y +LG
Sbjct: 3179 DGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWTWGKGDYFRLG 3238
Query: 267 TGNKNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
G+ ++ P + + +++V +A A A T G VY WG
Sbjct: 3239 HGSDVHVRKPQVVEGLRGKKIVHVAV--GALHCLAVTDSGQVYAWG 3282
Score = 132 bits (332), Expect = 8e-31
Identities = 89/294 (30%), Positives = 141/294 (47%), Gaps = 6/294 (2%)
Query: 11 TLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG 70
TLL + I+K V + L ++ EV+ +G LG G+ P+ +E
Sbjct: 4029 TLLESIQHVFIKKVAV-NSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIES 4087
Query: 71 LCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQV 130
L G ++ ++ G G H T G +Y WG Y +LG+ + + P ++ L +V
Sbjct: 4088 LRGIEVVDVAAG-GAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKP-KLVEALQGHRV 4145
Query: 131 VEVACGSH--HSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIAC 188
V++ACGS ++ L D V++WG + G++G G + P K+ + + VV + C
Sbjct: 4146 VDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLG-VVKVEC 4204
Query: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLAL 248
G S+A+ +G VY WG +LG G++ + P +V L V I G H +
Sbjct: 4205 GSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCC 4264
Query: 249 TDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKT 302
T++G +Y WG N GQLG G N + P + + + V AC SAHT A T
Sbjct: 4265 TEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSAHTLAWST 4318
Score = 129 bits (323), Expect = 9e-30
Identities = 89/298 (29%), Positives = 144/298 (48%), Gaps = 9/298 (3%)
Query: 11 TLLSPQEIASIR----KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPK 66
T+ P++I ++ K + A +T + +VF +G LG + P+
Sbjct: 3032 TVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPR 3091
Query: 67 KLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126
+E L K+I+ ++ GS H T G +Y WG Y +LG+G + P V LL
Sbjct: 3092 LIEALKTKRIRDIACGSS-HSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKV-LL 3149
Query: 127 IKQVVEVACGSH--HSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVV 184
+V++VACGS ++AL +G VF+WG + G++G G + P+ + L+ + V
Sbjct: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVC 3208
Query: 185 GIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAH 244
I CG S+A+ +G V+ WG +LG G++ + P V L + + G H
Sbjct: 3209 QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALH 3268
Query: 245 TLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKT 302
LA+TD G +YAWG N +GQ G G P + + + + AC S+H+ A T
Sbjct: 3269 CLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTT 3326
Score = 113 bits (283), Expect = 4e-25
Identities = 69/220 (31%), Positives = 105/220 (47%), Gaps = 3/220 (1%)
Query: 94 GVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG 153
G +Y WGHN QLG G + C L + V++ G A+ ADG+++A G
Sbjct: 3952 GTIYGWGHNHRGQLG-GIEGAKVKVPTPCEALATLRPVQLIGGEQTLFAVTADGKLYATG 4010
Query: 154 YNNCGQVGSGSTANQPTPRKVTNCLHI-KRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQ 212
Y G++G G T + TP + + H+ + V + G +A+ GEVY WG +G+
Sbjct: 4011 YGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGK 4070
Query: 213 LGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNN 272
LG GN P + +L + V + G AH+ +T G LY WG YG+LG + +
Sbjct: 4071 LGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSED 4130
Query: 273 LLSPAHI-MVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
L P + ++ RVV+IA + T V+ WG
Sbjct: 4131 QLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWG 4170
Score = 113 bits (282), Expect = 5e-25
Identities = 71/225 (31%), Positives = 114/225 (50%), Gaps = 9/225 (4%)
Query: 42 EVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKK----IKSLSYGSGPHVLLSTEDGVVY 97
EV+ +G LG GD PK + GK+ + ++ GS + T +G +Y
Sbjct: 515 EVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGS-TYSAAITAEGELY 573
Query: 98 AWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA--DGEVFAWGYN 155
WG Y +LG+G++ P+ V L +V++VACGS + LA +G+V++WG
Sbjct: 574 TWGRGNYGRLGHGSSEDEAIPMLV-AGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG 632
Query: 156 NCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGL 215
+ G++G G + TP K+ L VV + CG S+A+ +G+VY WG N +LG
Sbjct: 633 DYGKLGRGGSDGCKTP-KLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGH 691
Query: 216 GNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGAN 260
G + P + L V + G H LALT++ +++WG+N
Sbjct: 692 GTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSN 736
Score = 111 bits (278), Expect = 1e-24
Identities = 77/246 (31%), Positives = 118/246 (47%), Gaps = 7/246 (2%)
Query: 69 EGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIK 128
+G G I+ + G + T+ V+ WG N QLG G I L
Sbjct: 2937 KGNSGSLIRKKAAGLESAATIRTK---VFVWGLNDKDQLG-GLKGSKIKVPSFSETLSAL 2992
Query: 129 QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSG-STANQPTPRKVTNCL-HIKRVVGI 186
VV+VA GS A+ +G+V+A G G++G G S+ P PR++T ++ + V +
Sbjct: 2993 NVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAV 3052
Query: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTL 246
G + A+ +G+V+ WG +G+LG + N P + AL + + I CG +H+
Sbjct: 3053 HSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSA 3112
Query: 247 ALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV-EKERVVEIAACHSAHTSAAKTQGG 305
ALT G LY WG YG+LG G+ L P + V RV+++A + A T G
Sbjct: 3113 ALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDEG 3172
Query: 306 HVYMWG 311
V+ WG
Sbjct: 3173 LVFSWG 3178
Score = 99.4 bits (246), Expect = 7e-21
Identities = 77/279 (27%), Positives = 119/279 (42%), Gaps = 60/279 (21%)
Query: 96 VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFA---- 151
V WG G+ N I P+Q C L V ++AC + L+ +G V+
Sbjct: 425 VIGWGLIGWKYYANV-----IGPIQ-CEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN 478
Query: 152 ----------------------------------------WGYNNCGQVGSGSTANQPTP 171
WG + G++G G T P
Sbjct: 479 SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEP 538
Query: 172 RKV---TNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVA 228
+ + + K VV IACG T S A+ GE+Y WG G+LG G++ ++ P+ VA
Sbjct: 539 KVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVA 598
Query: 229 ALHSVCVNQIVCGY--AHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERV 286
L + V + CG A TLA+T+ G +++WG YG+LG G + +P ++EK +
Sbjct: 599 GLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPK--LIEKLQD 656
Query: 287 VEIAACH-SAHTSAAKTQGGHVYMWGQCRGQSVILPHLT 324
+++ + S A T+ G VY WG +G + L H T
Sbjct: 657 LDVVKVRCGSQFSIALTKDGQVYSWG--KGDNQRLGHGT 693
Score = 94.7 bits (234), Expect = 2e-19
Identities = 57/181 (31%), Positives = 96/181 (53%), Gaps = 12/181 (6%)
Query: 140 SMALAADGEVFAWGYNNCGQVG--SGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVL 197
+++ G ++ WG+N+ GQ+G G+ PTP + L +++G G+ + AV
Sbjct: 3945 TLSAGGSGTIYGWGHNHRGQLGGIEGAKVKVPTPCEALATLRPVQLIG---GEQTLFAVT 4001
Query: 198 DNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIV--CGYAHTLALTDEGLLY 255
+G++Y GY G+LG+G + TP + ++ V + ++ G H LAL+ EG +Y
Sbjct: 4002 ADGKLYATGYGAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVY 4061
Query: 256 AWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEI--AACHSAHTSAAKTQGGHVYMWGQC 313
+WG G+LG GN++ P ++E R +E+ A AH SA T G +Y WG+
Sbjct: 4062 SWGEAEDGKLGHGNRSPCDRPR--VIESLRGIEVVDVAAGGAH-SACVTAAGDLYTWGKG 4118
Query: 314 R 314
R
Sbjct: 4119 R 4119
Score = 87.8 bits (216), Expect = 2e-17
Identities = 58/168 (34%), Positives = 85/168 (50%), Gaps = 3/168 (1%)
Query: 28 GTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHV 87
G+ ++ L VT+N +V+ +G LG G + PK +E L + + GS +
Sbjct: 611 GSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKVRCGSQFSI 670
Query: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADG 147
L T+DG VY+WG +LG+GT P ++ L K+V++VA GS H +AL D
Sbjct: 671 AL-TKDGQVYSWGKGDNQRLGHGTEEHVRYP-KLLEGLQGKKVIDVAAGSTHCLALTEDS 728
Query: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMA 195
EV +WG N+ Q +P P + L K +VGIACG S A
Sbjct: 729 EVHSWGSNDQCQHFDTLRVTKPEPAALPG-LDTKHIVGIACGPAQSFA 775
Score = 41.2 bits (95), Expect = 0.002
Identities = 31/112 (27%), Positives = 46/112 (41%), Gaps = 16/112 (14%)
Query: 201 EVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGAN 260
EV GWG +G N + P++ L ++ V QI C L L+ G +Y N
Sbjct: 424 EVIGWGL-----IGWKYYANVIGPIQCEGLANLGVTQIACAEKRFLILSRNGRVYTQAYN 478
Query: 261 TYGQLGTGNKNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
++ L+P + + +V+IAA H A G VY WG
Sbjct: 479 ----------SDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWG 520
Score = 36.2 bits (82), Expect = 0.077
Identities = 25/81 (30%), Positives = 37/81 (45%), Gaps = 2/81 (2%)
Query: 15 PQEIASIR--KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72
PQ + +R K A L VTD+ +V+ +G N G G P ++GL
Sbjct: 3248 PQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLE 3307
Query: 73 GKKIKSLSYGSGPHVLLSTED 93
G+KI ++ GS V +T D
Sbjct: 3308 GQKITRVACGSSHSVAWTTVD 3328
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 140 bits (352), Expect = 4e-33
Identities = 90/274 (32%), Positives = 155/274 (56%), Gaps = 7/274 (2%)
Query: 30 SASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLL 89
S ++ +T++ EVF +G LG G++ P+++E L G+++ +S G H +
Sbjct: 4090 SDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGF-KHSAV 4148
Query: 90 STEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGE- 148
T DG ++ +G+ Y +LG G T+ P +V T L Q+ +VACG +H++A++ADG
Sbjct: 4149 VTSDGKLFTFGNGDYGRLGLGNTSNKKLPERV-TALEGYQIGQVACGLNHTLAVSADGSM 4207
Query: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208
V+A+G + G++G G++ + +P+K+ I + +ACG S+A+ +G VY +G +
Sbjct: 4208 VWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIG-IKKVACGTQFSVALTKDGHVYTFGQD 4266
Query: 209 GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268
L G N P ++ L V + + G HTLAL G +YAWG+N+ GQLG G
Sbjct: 4267 RLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLG 4326
Query: 269 NKNNLLSPAHIM-VEKERVVEIAA--CHSAHTSA 299
+ N++ P + ++ + V +I+A CHSA +A
Sbjct: 4327 HTNHVREPTLVTGLQGKNVRQISAGRCHSAAWTA 4360
Score = 136 bits (343), Expect = 4e-32
Identities = 89/289 (30%), Positives = 147/289 (50%), Gaps = 6/289 (2%)
Query: 40 NDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSL--SYGSGPHVLLSTEDGVVY 97
N V G LG G++ V + L G + L S GS H + TE G V+
Sbjct: 4045 NGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 4104
Query: 98 AWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNC 157
+WG Y +LG+G +++ P Q+ L ++VV+++CG HS + +DG++F +G +
Sbjct: 4105 SWGDGDYGKLGHGNSDRQRRPRQI-EALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY 4163
Query: 158 GQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGE-VYGWGYNGNGQLGLG 216
G++G G+T+N+ P +VT L ++ +ACG ++AV +G V+ +G G+LGLG
Sbjct: 4164 GRLGLGNTSNKKLPERVT-ALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLG 4222
Query: 217 NNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSP 276
N+ + +P ++ L + + ++ CG ++ALT +G +Y +G + L G N P
Sbjct: 4223 NSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRP 4282
Query: 277 AHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVILPHLTH 325
I V ++E A + HT A G VY WG + L H H
Sbjct: 4283 QQIPVLAGVIIEDVAVGAEHT-LALASNGDVYAWGSNSEGQLGLGHTNH 4330
Score = 129 bits (324), Expect = 7e-30
Identities = 86/282 (30%), Positives = 145/282 (51%), Gaps = 9/282 (3%)
Query: 33 EALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTE 92
+A V++ EV+V+G N S+ L G + L PK +++ G ++ST
Sbjct: 364 DAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSF--SDAQTIEAGQYCTFVIST- 420
Query: 93 DGVVYAWGHNGYSQLGNGTTNQG--IAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVF 150
DG V A G Y +LG G +N + + + IK+V H++A +GEVF
Sbjct: 421 DGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVF 480
Query: 151 AWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGN 210
+WG + G++G G+++ Q P+ + L K VV ++ G S AV ++GE+Y WG
Sbjct: 481 SWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDF 540
Query: 211 GQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEG-LLYAWGANTYGQLGTGN 269
G+LG G++ ++ P V + + V ++ CG +HT+AL+ +G ++++G G+LG G+
Sbjct: 541 GRLGHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGD 598
Query: 270 KNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
N + P I + + C + +S A T G VY WG
Sbjct: 599 TNRVYKPKVIEALQGMFIR-KVCAGSQSSLALTSTGQVYAWG 639
Score = 123 bits (308), Expect = 5e-28
Identities = 87/253 (34%), Positives = 128/253 (50%), Gaps = 10/253 (3%)
Query: 20 SIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG-LCGKKIKS 78
SI+K S L T EVF +G LG G++ + PK ++G L GK +
Sbjct: 456 SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVC 515
Query: 79 LSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSH 138
+S G H TEDG +Y WG + +LG+G +N P V I V EV+CGS
Sbjct: 516 VSAGYR-HSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKD---ISNVGEVSCGSS 571
Query: 139 HSMALAADGE-VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVL 197
H++AL+ DG V+++G + G++G G T N+ KV L + + G SS+A+
Sbjct: 572 HTIALSKDGRTVWSFGGGDNGKLGHGDT-NRVYKPKVIEALQGMFIRKVCAGSQSSLALT 630
Query: 198 DNGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYA 256
G+VY WG LG G++ L P + L + + + G +H LAL+ + +YA
Sbjct: 631 STGQVYAWGC--GACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYA 688
Query: 257 WGANTYGQLGTGN 269
WG N+ GQ G GN
Sbjct: 689 WGNNSMGQCGQGN 701
Score = 121 bits (303), Expect = 2e-27
Identities = 80/259 (30%), Positives = 125/259 (48%), Gaps = 6/259 (2%)
Query: 54 LGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN 113
LG +NQSTL E K S S GS H L T +G V++WG Y +LG+G ++
Sbjct: 437 LGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKLGHGNSS 496
Query: 114 QGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRK 173
P + L K VV V+ G HS A+ DGE++ WG + G++G G + ++ P
Sbjct: 497 TQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTL 556
Query: 174 VTNCLHIKRVVGIACGQTSSMAVLDNGE-VYGWGYNGNGQLGLGNNGNQLTPVRVAALHS 232
V + I V ++CG + ++A+ +G V+ +G NG+LG G+ P + AL
Sbjct: 557 VKD---ISNVGEVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQG 613
Query: 233 VCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAAC 292
+ + ++ G +LALT G +YAWG G+ L + R+V+++
Sbjct: 614 MFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIG 673
Query: 293 HSAHTSAAKTQGGHVYMWG 311
S A + VY WG
Sbjct: 674 DS--HCLALSHDNEVYAWG 690
Score = 108 bits (271), Expect = 9e-24
Identities = 67/216 (31%), Positives = 114/216 (52%), Gaps = 10/216 (4%)
Query: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
VT++ E++ +G LG GD+ S +P ++ + + +S GS + LS + V
Sbjct: 526 VTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDI--SNVGEVSCGSSHTIALSKDGRTV 583
Query: 97 YAWGHNGYSQLGNGTTNQGIAP--VQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGY 154
+++G +LG+G TN+ P ++ + I++V GS S+AL + G+V+AWG
Sbjct: 584 WSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKV---CAGSQSSLALTSTGQVYAWGC 640
Query: 155 NNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLG 214
C +G GS+ K+ L R+V ++ G + +A+ + EVY WG N GQ G
Sbjct: 641 GAC--LGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCG 698
Query: 215 LGNNGNQLT-PVRVAALHSVCVNQIVCGYAHTLALT 249
GN+ +T P +V+ L + + QI G +H+LA T
Sbjct: 699 QGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLAWT 734
Score = 105 bits (261), Expect = 1e-22
Identities = 66/228 (28%), Positives = 104/228 (45%), Gaps = 26/228 (11%)
Query: 96 VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYN 155
VY WG + QL N + Q +V CG + + + A+G V A G
Sbjct: 3999 VYLWGAGRHGQLAEAGRNVMVPAAAPS----FSQAQQVICGQNCTFVIQANGTVLACGEG 4054
Query: 156 NCGQVGSGSTANQPTPRKVTNCLHIKRVVGI-----------ACGQTS-SMAVLDNGEVY 203
+ G++G G++ + LH+ V+ +CG SMA+ ++GEV+
Sbjct: 4055 SYGRLGQGNSDD----------LHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVF 4104
Query: 204 GWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYG 263
WG G+LG GN+ Q P ++ AL V Q+ CG+ H+ +T +G L+ +G YG
Sbjct: 4105 SWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDYG 4164
Query: 264 QLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
+LG GN +N P + + + AC HT A G V+ +G
Sbjct: 4165 RLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFG 4212
Score = 75.1 bits (183), Expect = 1e-13
Identities = 48/168 (28%), Positives = 76/168 (45%), Gaps = 6/168 (3%)
Query: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207
EV+ WG N+ Q+ G+ P+ + + I GQ + + +G V G
Sbjct: 373 EVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQT---IEAGQYCTFVISTDGSVRACGK 429
Query: 208 NGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYA---HTLALTDEGLLYAWGANTYGQ 264
G+LGLG++ NQ T ++ + ++ HTLA T EG +++WG YG+
Sbjct: 430 GSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGK 489
Query: 265 LGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312
LG GN + P I + V + SAA T+ G +Y WG+
Sbjct: 490 LGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGE 537
Score = 66.6 bits (161), Expect = 5e-11
Identities = 48/141 (34%), Positives = 71/141 (50%), Gaps = 10/141 (7%)
Query: 21 IRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQST-LVPKKLEGLCGKKIKSL 79
IRK C G+ +S AL T +V+ +G CLG G +++T L PK +E L +I +
Sbjct: 616 IRKVCA-GSQSSLAL--TSTGQVYAWGCGA--CLGCGSSEATALRPKLIEELAATRIVDV 670
Query: 80 SYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHH 139
S G H L + D VYAWG+N Q G G + I + + L + +++ G+ H
Sbjct: 671 SIGDS-HCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSH 729
Query: 140 SM---ALAADGEVFAWGYNNC 157
S+ AL D +V AW C
Sbjct: 730 SLAWTALPRDRQVVAWHRPYC 750
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 131 bits (330), Expect = 1e-30
Identities = 96/281 (34%), Positives = 143/281 (50%), Gaps = 10/281 (3%)
Query: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
VT N+++++FG N LG G + P ++ L +K+K + G H L+STE G V
Sbjct: 50 VTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-HTLVSTEGGNV 108
Query: 97 YAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNN 156
YA G N QLG G T + + ++ +++ GS+ S AL DG +F WG N+
Sbjct: 109 YATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNS 168
Query: 157 CGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLG 216
GQ+G + +N P++VT K V I+CG S V +GE+Y +G NG+LGL
Sbjct: 169 EGQIGLKNVSNVCVPQQVTIG---KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
Query: 217 NN--GNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGN-KNNL 273
N GN TP V+ + + Q+ CG HT+ LT E +Y +G +GQLG G
Sbjct: 226 NQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFET 283
Query: 274 LSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCR 314
P I +++ + +C HT A T G +Y +G R
Sbjct: 284 SEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGR 323
Score = 106 bits (264), Expect = 6e-23
Identities = 69/230 (30%), Positives = 114/230 (49%), Gaps = 8/230 (3%)
Query: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVA-CGSHHSMALA 144
H + T + +Y +G N + QLG G+ + P C L + V++A CG +H++
Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPT--CVKALKPEKVKLAACGRNHTLVST 103
Query: 145 ADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204
G V+A G NN GQ+G G T + T ++ ++ ++ G +S A+ ++G ++
Sbjct: 104 EGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFM 163
Query: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQ 264
WG N GQ+GL N N P +V V+ I CGY H+ +T +G LY +G G+
Sbjct: 164 WGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGK 221
Query: 265 LGTGNK--NNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312
LG N+ N +P + E+V+++ AC HT + + GQ
Sbjct: 222 LGLPNQLLGNHRTPQLVSEIPEKVIQV-ACGGEHTVVLTENAVYTFGLGQ 270
Score = 95.9 bits (237), Expect = 8e-20
Identities = 61/193 (31%), Positives = 100/193 (51%), Gaps = 5/193 (2%)
Query: 131 VEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQ 190
V ++CG HS + + +++ +G NN GQ+G GS + P V L ++V ACG+
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV-KALKPEKVKLAACGR 96
Query: 191 TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSV-CVNQIVCGYAHTLALT 249
++ + G VY G N GQLGLG+ + T ++ S + Q+ G + ALT
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
Query: 250 DEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYM 309
++G L+ WG N+ GQ+G N +N+ P + + K V +C H SA T G +Y+
Sbjct: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP--VSWISCGYYH-SAFVTTDGELYV 213
Query: 310 WGQCRGQSVILPH 322
+G+ + LP+
Sbjct: 214 FGEPENGKLGLPN 226
Score = 85.1 bits (209), Expect = 1e-16
Identities = 61/191 (31%), Positives = 88/191 (46%), Gaps = 8/191 (4%)
Query: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYA 243
V ++CG S V N ++Y +G N GQLGLG+ P V AL V CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 244 HTLALTDEGLLYAWGANTYGQLGTGN--KNNLLSPAHIMVEKERVVEIAACHSAHTSAAK 301
HTL T+ G +YA G N GQLG G+ + N + ++ +++A ++TSAA
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSA--GSNTSAAL 155
Query: 302 TQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESLK 361
T+ G ++MWG + L ++++ V P VSW H F+T L
Sbjct: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKP-VSWISCGYYHSAFVTTDGEL- 211
Query: 362 KEFDSPETADL 372
F PE L
Sbjct: 212 YVFGEPENGKL 222
Score = 79.0 bits (193), Expect = 1e-14
Identities = 58/219 (26%), Positives = 104/219 (47%), Gaps = 8/219 (3%)
Query: 28 GTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHV 87
G++ S AL T++ +F++G N +G + + VP+++ GK + +S G H
Sbjct: 148 GSNTSAAL--TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYY-HS 202
Query: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADG 147
T DG +Y +G +LG G + + ++V++VACG H++ L +
Sbjct: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-EN 261
Query: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207
V+ +G GQ+G G+ + + KV + + + I+CG+ + + D G +Y +G
Sbjct: 262 AVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGD 321
Query: 208 NGNGQLGLG--NNGNQLTPVRVAALHSVCVNQIVCGYAH 244
+G+LGLG N N P + V + CG H
Sbjct: 322 GRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
Score = 51.6 bits (122), Expect = 2e-06
Identities = 41/135 (30%), Positives = 61/135 (45%), Gaps = 5/135 (3%)
Query: 14 SPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ-STLVPKKLEGLC 72
+PQ ++ I + + E V + V+ FGL LG G T PK +E +
Sbjct: 234 TPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
Query: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN--QGIAPVQVCTNLLIKQV 130
+ I +S G H L T+ G++Y +G + +LG G N P +C+N L V
Sbjct: 294 DQTISYISCGEN-HTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPT-LCSNFLRFIV 351
Query: 131 VEVACGSHHSMALAA 145
VACG H + AA
Sbjct: 352 KLVACGGCHMVVFAA 366
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/198 (23%), Positives = 84/198 (42%), Gaps = 24/198 (12%)
Query: 4 VGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLG-------- 55
+G + + PQ++ + + +VT + E++VFG + LG
Sbjct: 172 IGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGN 231
Query: 56 --TGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN 113
T S + K ++ CG G H ++ TE+ VY +G + QLG GT
Sbjct: 232 HRTPQLVSEIPEKVIQVACG----------GEHTVVLTEN-AVYTFGLGQFGQLGLGTFL 280
Query: 114 QGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSG--STANQPTP 171
+ +V N+ + + ++CG +H+ + G ++ +G G++G G + N P
Sbjct: 281 FETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIP 340
Query: 172 RKVTNCLHIKRVVGIACG 189
+N L V +ACG
Sbjct: 341 TLCSNFLRF-IVKLVACG 357
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 131 bits (330), Expect = 1e-30
Identities = 96/281 (34%), Positives = 143/281 (50%), Gaps = 10/281 (3%)
Query: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
VT N+++++FG N LG G + P ++ L +K+K + G H L+STE G V
Sbjct: 50 VTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN-HTLVSTEGGNV 108
Query: 97 YAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNN 156
YA G N QLG G T + + ++ +++ GS+ S AL DG +F WG N+
Sbjct: 109 YATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNS 168
Query: 157 CGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLG 216
GQ+G + +N P++VT K V I+CG S V +GE+Y +G NG+LGL
Sbjct: 169 EGQIGLKNVSNVCVPQQVTIG---KPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP 225
Query: 217 NN--GNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGN-KNNL 273
N GN TP V+ + + Q+ CG HT+ LT E +Y +G +GQLG G
Sbjct: 226 NQLLGNHRTPQLVSEIPEKVI-QVACGGEHTVVLT-ENAVYTFGLGQFGQLGLGTFLFET 283
Query: 274 LSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCR 314
P I +++ + +C HT A T G +Y +G R
Sbjct: 284 SEPKVIENIRDQTISYISCGENHT-ALITDIGLMYTFGDGR 323
Score = 106 bits (264), Expect = 6e-23
Identities = 69/230 (30%), Positives = 114/230 (49%), Gaps = 8/230 (3%)
Query: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVA-CGSHHSMALA 144
H + T + +Y +G N + QLG G+ + P C L + V++A CG +H++
Sbjct: 46 HSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPT--CVKALKPEKVKLAACGRNHTLVST 103
Query: 145 ADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204
G V+A G NN GQ+G G T + T ++ ++ ++ G +S A+ ++G ++
Sbjct: 104 EGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALTEDGRLFM 163
Query: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQ 264
WG N GQ+GL N N P +V V+ I CGY H+ +T +G LY +G G+
Sbjct: 164 WGDNSEGQIGLKNVSNVCVPQQVTI--GKPVSWISCGYYHSAFVTTDGELYVFGEPENGK 221
Query: 265 LGTGNK--NNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312
LG N+ N +P + E+V+++ AC HT + + GQ
Sbjct: 222 LGLPNQLLGNHRTPQLVSEIPEKVIQV-ACGGEHTVVLTENAVYTFGLGQ 270
Score = 95.9 bits (237), Expect = 8e-20
Identities = 61/193 (31%), Positives = 100/193 (51%), Gaps = 5/193 (2%)
Query: 131 VEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQ 190
V ++CG HS + + +++ +G NN GQ+G GS + P V L ++V ACG+
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCV-KALKPEKVKLAACGR 96
Query: 191 TSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSV-CVNQIVCGYAHTLALT 249
++ + G VY G N GQLGLG+ + T ++ S + Q+ G + ALT
Sbjct: 97 NHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAALT 156
Query: 250 DEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYM 309
++G L+ WG N+ GQ+G N +N+ P + + K V +C H SA T G +Y+
Sbjct: 157 EDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKP--VSWISCGYYH-SAFVTTDGELYV 213
Query: 310 WGQCRGQSVILPH 322
+G+ + LP+
Sbjct: 214 FGEPENGKLGLPN 226
Score = 85.1 bits (209), Expect = 1e-16
Identities = 61/191 (31%), Positives = 88/191 (46%), Gaps = 8/191 (4%)
Query: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYA 243
V ++CG S V N ++Y +G N GQLGLG+ P V AL V CG
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 244 HTLALTDEGLLYAWGANTYGQLGTGN--KNNLLSPAHIMVEKERVVEIAACHSAHTSAAK 301
HTL T+ G +YA G N GQLG G+ + N + ++ +++A ++TSAA
Sbjct: 98 HTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSA--GSNTSAAL 155
Query: 302 TQGGHVYMWGQCRGQSVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDFLTVAESLK 361
T+ G ++MWG + L ++++ V P VSW H F+T L
Sbjct: 156 TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQV--TIGKP-VSWISCGYYHSAFVTTDGEL- 211
Query: 362 KEFDSPETADL 372
F PE L
Sbjct: 212 YVFGEPENGKL 222
Score = 79.0 bits (193), Expect = 1e-14
Identities = 58/219 (26%), Positives = 104/219 (47%), Gaps = 8/219 (3%)
Query: 28 GTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHV 87
G++ S AL T++ +F++G N +G + + VP+++ GK + +S G H
Sbjct: 148 GSNTSAAL--TEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVT--IGKPVSWISCGYY-HS 202
Query: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADG 147
T DG +Y +G +LG G + + ++V++VACG H++ L +
Sbjct: 203 AFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTVVLT-EN 261
Query: 148 EVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207
V+ +G GQ+G G+ + + KV + + + I+CG+ + + D G +Y +G
Sbjct: 262 AVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGD 321
Query: 208 NGNGQLGLG--NNGNQLTPVRVAALHSVCVNQIVCGYAH 244
+G+LGLG N N P + V + CG H
Sbjct: 322 GRHGKLGLGLENFTNHFIPTLCSNFLRFIVKLVACGGCH 360
Score = 51.6 bits (122), Expect = 2e-06
Identities = 41/135 (30%), Positives = 61/135 (45%), Gaps = 5/135 (3%)
Query: 14 SPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ-STLVPKKLEGLC 72
+PQ ++ I + + E V + V+ FGL LG G T PK +E +
Sbjct: 234 TPQLVSEIPEKVIQVACGGEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIR 293
Query: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN--QGIAPVQVCTNLLIKQV 130
+ I +S G H L T+ G++Y +G + +LG G N P +C+N L V
Sbjct: 294 DQTISYISCGEN-HTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPT-LCSNFLRFIV 351
Query: 131 VEVACGSHHSMALAA 145
VACG H + AA
Sbjct: 352 KLVACGGCHMVVFAA 366
Score = 48.5 bits (114), Expect = 1e-05
Identities = 46/198 (23%), Positives = 84/198 (42%), Gaps = 24/198 (12%)
Query: 4 VGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLG-------- 55
+G + + PQ++ + + +VT + E++VFG + LG
Sbjct: 172 IGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGN 231
Query: 56 --TGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN 113
T S + K ++ CG G H ++ TE+ VY +G + QLG GT
Sbjct: 232 HRTPQLVSEIPEKVIQVACG----------GEHTVVLTEN-AVYTFGLGQFGQLGLGTFL 280
Query: 114 QGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSG--STANQPTP 171
+ +V N+ + + ++CG +H+ + G ++ +G G++G G + N P
Sbjct: 281 FETSEPKVIENIRDQTISYISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIP 340
Query: 172 RKVTNCLHIKRVVGIACG 189
+N L V +ACG
Sbjct: 341 TLCSNFLRF-IVKLVACG 357
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 127 bits (320), Expect = 2e-29
Identities = 76/240 (31%), Positives = 127/240 (52%), Gaps = 6/240 (2%)
Query: 74 KKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEV 133
KKI ++ G H L ++ G ++AWG N + QLG G Q+ +L + ++
Sbjct: 138 KKIIQITCGDY-HSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQI 196
Query: 134 ACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSS 193
+ G HSMAL+ G +++WG N CGQ+G G T ++ P + L ++V +ACG + S
Sbjct: 197 SAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEG-LDNQKVEFVACGGSHS 255
Query: 194 MAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLA-LTDEG 252
+ +G ++ +G +GQLG + N+L P VA L V QI CG HTLA ++D G
Sbjct: 256 ALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLG 315
Query: 253 LLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGH--VYMW 310
++++G+ GQLG G + L P + V +++ + H++ GG+ + +W
Sbjct: 316 KVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLES-HTSEKELIMIAGGNQSILLW 374
Score = 123 bits (309), Expect = 4e-28
Identities = 78/241 (32%), Positives = 125/241 (51%), Gaps = 15/241 (6%)
Query: 73 GKKIKSLSYGSGP-HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVV 131
GK +K S G H+L+ + DG + + N + ++ + L K+++
Sbjct: 94 GKNMKIHSVDQGAEHMLILSSDGKPFEYD------------NYSMKHLRFESILQEKKII 141
Query: 132 EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQT 191
++ CG +HS+AL+ GE+FAWG N GQ+G G T ++ L + I+ G+
Sbjct: 142 QITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEA 201
Query: 192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
SMA+ +G +Y WG N GQLGLG+ ++ P + L + V + CG +H+ LT +
Sbjct: 202 HSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVACGGSHSALLTQD 261
Query: 252 GLLYAWGANTYGQLGTGNKNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMW 310
GLL+ +GA +GQLG + N L P + + RV +I AC HT A + G V+ +
Sbjct: 262 GLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQI-ACGRWHTLAYVSDLGKVFSF 320
Query: 311 G 311
G
Sbjct: 321 G 321
Score = 99.8 bits (247), Expect = 6e-21
Identities = 71/196 (36%), Positives = 100/196 (51%), Gaps = 5/196 (2%)
Query: 34 ALYVTDNDEVFVFGLNYSNCLGTGDN-QSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTE 92
+L ++ E+F +G N LG G ST P+ +E L G + +S G + LS
Sbjct: 150 SLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMS 209
Query: 93 DGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAW 152
G +Y+WG N QLG G T P + L ++V VACG HS L DG +F +
Sbjct: 210 -GNIYSWGKNECGQLGLGHTESKDDP-SLIEGLDNQKVEFVACGGSHSALLTQDGLLFTF 267
Query: 153 GYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMA-VLDNGEVYGWGYNGNG 211
G GQ+G ST N+ P V + RV IACG+ ++A V D G+V+ +G +G
Sbjct: 268 GAGKHGQLGHNSTQNELRPCLVAELVGY-RVTQIACGRWHTLAYVSDLGKVFSFGSGKDG 326
Query: 212 QLGLGNNGNQLTPVRV 227
QLG G +QL P+ V
Sbjct: 327 QLGNGGTRDQLMPLPV 342
Score = 84.3 bits (207), Expect = 2e-16
Identities = 57/181 (31%), Positives = 101/181 (55%), Gaps = 9/181 (4%)
Query: 6 KWPIFTLLSPQEIASIRKACVFGTSASEA--LYVTDNDEVFVFGLNYSNCLGTGDNQSTL 63
K+P T +PQ + + + SA EA + ++ + ++ +G N LG G +S
Sbjct: 175 KFPSTT--TPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKD 232
Query: 64 VPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCT 123
P +EGL +K++ ++ G G H L T+DG+++ +G + QLG+ +T + P V
Sbjct: 233 DPSLIEGLDNQKVEFVACG-GSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLV-A 290
Query: 124 NLLIKQVVEVACGSHHSMALAAD-GEVFAWGYNNCGQVGSGSTANQ--PTPRKVTNCLHI 180
L+ +V ++ACG H++A +D G+VF++G GQ+G+G T +Q P P KV++ +
Sbjct: 291 ELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEEL 350
Query: 181 K 181
K
Sbjct: 351 K 351
Score = 29.3 bits (64), Expect = 9.4
Identities = 23/95 (24%), Positives = 42/95 (44%), Gaps = 10/95 (10%)
Query: 36 YVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLL---STE 92
YV+D +VF FG LG G + L+P ++ +++K S+ S +++ +
Sbjct: 310 YVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQ 369
Query: 93 DGVVYAWGHNGY-------SQLGNGTTNQGIAPVQ 120
+++ N Y L GT + IA V+
Sbjct: 370 SILLWIKKENSYVNLKRTIPTLNEGTVKRWIADVE 404
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 125 bits (314), Expect = 1e-28
Identities = 86/265 (32%), Positives = 132/265 (49%), Gaps = 13/265 (4%)
Query: 57 GDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGI 116
G + L ++ G G ++ + G +LL T V+ + G N QLG +G
Sbjct: 6 GADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVL-SCGDNSRGQLGRRGAQRGE 64
Query: 117 AP--VQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQP-TPRK 173
P +Q L++ V +CG HS+A+ G VFAWG + GQ+G G TP+K
Sbjct: 65 LPEPIQALETLIVDLV---SCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKK 121
Query: 174 VTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-GNQLTPVRVAALHS 232
+ IK ++ ++CG S+A+ + +V+ WG N +GQLGLG +Q +P RV +L
Sbjct: 122 IMTLNDIK-IIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEG 180
Query: 233 VCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKN---NLLSPAHIMVEKERVVEI 289
+ + Q+ G AH+ AL+ G + WG+N+ GQL +N P + K V
Sbjct: 181 IPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVY 240
Query: 290 AACHSAHTSAAKTQGGHVYMWGQCR 314
+C AHT A TQ G V+ +G R
Sbjct: 241 ISCGDAHT-AVLTQDGKVFTFGDNR 264
Score = 120 bits (301), Expect = 3e-27
Identities = 93/284 (32%), Positives = 138/284 (48%), Gaps = 11/284 (3%)
Query: 34 ALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTED 93
+L + N V G N LG Q +P+ ++ L + +S G H L
Sbjct: 35 SLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGK-EHSLAVCHK 93
Query: 94 GVVYAWGHNGYSQLGNGTTNQ-GIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAW 152
G V+AWG QLG G + P ++ T IK +++V+CG +HS+AL+ D +VF+W
Sbjct: 94 GRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIK-IIQVSCGHYHSLALSKDSQVFSW 152
Query: 153 GYNNCGQVGSGST-ANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNG 211
G N+ GQ+G G +Q +P++V + I + +A G S A+ G +GWG N G
Sbjct: 153 GKNSHGQLGLGKEFPSQASPQRVRSLEGIP-LAQVAAGGAHSFALSLCGTSFGWGSNSAG 211
Query: 212 QLGLGNNGNQLT---PVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268
QL L + P+ V AL ++ V I CG AHT LT +G ++ +G N GQLG
Sbjct: 212 QLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYS 271
Query: 269 NKNNLLSPAHIMVEK-ERVVEIAACHSAHTSAAKTQGGHVYMWG 311
P +VE+ + +V C S HT A G V +G
Sbjct: 272 PTPEKRGPQ--LVERIDGLVSQIDCGSYHTLAYVHTTGQVVSFG 313
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 113 bits (283), Expect = 4e-25
Identities = 79/274 (28%), Positives = 136/274 (49%), Gaps = 30/274 (10%)
Query: 65 PKKLEGLCGKKIKSLSYGS-GPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCT 123
P + L G +++++ GS H LL T +G +++WG N QLG+G T + AP ++
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAP-RLIE 197
Query: 124 NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQ-PTPRKVTNCLHIKR 182
L + +V ACG +H++AL G VFA+G N GQ+G G+ + P+P ++ + +
Sbjct: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM--YNGQP 255
Query: 183 VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGN------------QLTPVRVAA- 229
+ +ACG SM + G +Y +G GQLG ++G +L P RVA
Sbjct: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 230 -----------LHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAH 278
+ +V V + CG HTL L + +++WG YG+LG + + + P
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
Query: 279 IMVEKERVVEIAACHSAHT-SAAKTQGGHVYMWG 311
+ + + ++ +T S A ++ G ++ WG
Sbjct: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
Score = 106 bits (264), Expect = 6e-23
Identities = 76/277 (27%), Positives = 130/277 (46%), Gaps = 30/277 (10%)
Query: 18 IASIR-KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKI 76
+A +R + V G+ A+ +L +T +++ +G N LG GD + P+ +EGL + I
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI 204
Query: 77 KSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGI-APVQVCTNLLIKQVVEVAC 135
S + G H L TE G V+A+G N QLG G + +P Q+ N + + ++AC
Sbjct: 205 VSAACGRN-HTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261
Query: 136 GSHHSMALAADGEVFAWGYNNCGQVGSGSTAN------------QPTPRKVT-------- 175
G+ SM + G ++++G GQ+G S + PR+V
Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
Query: 176 -NCLHIKRVV--GIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTP--VRVAAL 230
L + VV +ACG ++ + V+ WG+ G G+LG +++ P V++
Sbjct: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDF 381
Query: 231 HSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267
+QI GY + A+++ G L+ WGA + T
Sbjct: 382 PGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST 418
Score = 77.0 bits (188), Expect = 4e-14
Identities = 69/264 (26%), Positives = 118/264 (44%), Gaps = 35/264 (13%)
Query: 32 SEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC-GKKIKSLSYGSGPHVLLS 90
+ L +T+ VF FG N LG G NQ+ VP + + G+ I ++ G+ +++
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLG-NQTDAVPSPAQIMYNGQPITKMACGAEFSMIMD 270
Query: 91 TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTN---------------------LLIKQ 129
+ G +Y++G Y QLG+ + + IA Q L +
Sbjct: 271 CK-GNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
Query: 130 VV--EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVG-I 186
VV +VACG++H++ L + VF+WG+ G++G ++ PR V R I
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQI 389
Query: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTL 246
G T S AV + G ++ WG + + + P V L + + CG + +
Sbjct: 390 YAGYTCSFAVSEVGGLFFWGATNT------SRESTMYPKAVQDLCGWRIRSLACGKSSII 443
Query: 247 ALTDEGLLYAWGAN-TYGQLGTGN 269
DE + +WG + T+G+LG G+
Sbjct: 444 VAADESTI-SWGPSPTFGELGYGD 466
Score = 38.5 bits (88), Expect = 0.015
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 10/92 (10%)
Query: 60 QSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN-GYSQLGNG----TTNQ 114
+ST+ PK ++ LCG +I+SL+ G ++ + E + +WG + + +LG G ++
Sbjct: 416 ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI--SWGPSPTFGELGYGDHKPKSST 473
Query: 115 GIAPVQVCTNLLIKQVVEVACGSHHSMALAAD 146
V+ + +Q VA G HS+ +A D
Sbjct: 474 AAQEVKTLDGIFSEQ---VAMGYSHSLVIARD 502
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 113 bits (283), Expect = 4e-25
Identities = 79/274 (28%), Positives = 136/274 (49%), Gaps = 30/274 (10%)
Query: 65 PKKLEGLCGKKIKSLSYGS-GPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCT 123
P + L G +++++ GS H LL T +G +++WG N QLG+G T + AP ++
Sbjct: 139 PHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAP-RLIE 197
Query: 124 NLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQ-PTPRKVTNCLHIKR 182
L + +V ACG +H++AL G VFA+G N GQ+G G+ + P+P ++ + +
Sbjct: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIM--YNGQP 255
Query: 183 VVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGN------------QLTPVRVAA- 229
+ +ACG SM + G +Y +G GQLG ++G +L P RVA
Sbjct: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 230 -----------LHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAH 278
+ +V V + CG HTL L + +++WG YG+LG + + + P
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
Query: 279 IMVEKERVVEIAACHSAHT-SAAKTQGGHVYMWG 311
+ + + ++ +T S A ++ G ++ WG
Sbjct: 376 VKLFDFPGRGASQIYAGYTCSFAVSEVGGLFFWG 409
Score = 106 bits (264), Expect = 6e-23
Identities = 76/277 (27%), Positives = 130/277 (46%), Gaps = 30/277 (10%)
Query: 18 IASIR-KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKI 76
+A +R + V G+ A+ +L +T +++ +G N LG GD + P+ +EGL + I
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHEVI 204
Query: 77 KSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGI-APVQVCTNLLIKQVVEVAC 135
S + G H L TE G V+A+G N QLG G + +P Q+ N + + ++AC
Sbjct: 205 VSAACGRN-HTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN--GQPITKMAC 261
Query: 136 GSHHSMALAADGEVFAWGYNNCGQVGSGSTAN------------QPTPRKVT-------- 175
G+ SM + G ++++G GQ+G S + PR+V
Sbjct: 262 GAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKD 321
Query: 176 -NCLHIKRVV--GIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTP--VRVAAL 230
L + VV +ACG ++ + V+ WG+ G G+LG +++ P V++
Sbjct: 322 GQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDF 381
Query: 231 HSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGT 267
+QI GY + A+++ G L+ WGA + T
Sbjct: 382 PGRGASQIYAGYTCSFAVSEVGGLFFWGATNTSREST 418
Score = 77.0 bits (188), Expect = 4e-14
Identities = 69/264 (26%), Positives = 118/264 (44%), Gaps = 35/264 (13%)
Query: 32 SEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC-GKKIKSLSYGSGPHVLLS 90
+ L +T+ VF FG N LG G NQ+ VP + + G+ I ++ G+ +++
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLG-NQTDAVPSPAQIMYNGQPITKMACGAEFSMIMD 270
Query: 91 TEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTN---------------------LLIKQ 129
+ G +Y++G Y QLG+ + + IA Q L +
Sbjct: 271 CK-GNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIEKTKDGQILPVPN 329
Query: 130 VV--EVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVG-I 186
VV +VACG++H++ L + VF+WG+ G++G ++ PR V R I
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQI 389
Query: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTL 246
G T S AV + G ++ WG + + + P V L + + CG + +
Sbjct: 390 YAGYTCSFAVSEVGGLFFWGATNT------SRESTMYPKAVQDLCGWRIRSLACGKSSII 443
Query: 247 ALTDEGLLYAWGAN-TYGQLGTGN 269
DE + +WG + T+G+LG G+
Sbjct: 444 VAADESTI-SWGPSPTFGELGYGD 466
Score = 38.5 bits (88), Expect = 0.015
Identities = 26/92 (28%), Positives = 48/92 (52%), Gaps = 10/92 (10%)
Query: 60 QSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN-GYSQLGNG----TTNQ 114
+ST+ PK ++ LCG +I+SL+ G ++ + E + +WG + + +LG G ++
Sbjct: 416 ESTMYPKAVQDLCGWRIRSLACGKSSIIVAADESTI--SWGPSPTFGELGYGDHKPKSST 473
Query: 115 GIAPVQVCTNLLIKQVVEVACGSHHSMALAAD 146
V+ + +Q VA G HS+ +A D
Sbjct: 474 AAQEVKTLDGIFSEQ---VAMGYSHSLVIARD 502
>gi|6912330 deafness locus associated putative guanine nucleotide
exchange factor [Homo sapiens]
Length = 458
Score = 103 bits (256), Expect = 5e-22
Identities = 87/298 (29%), Positives = 136/298 (45%), Gaps = 27/298 (9%)
Query: 30 SASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLL 89
SASEA +F +G N LG G + L+P++L C + G G H +
Sbjct: 6 SASEAAPAAA--ALFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAV 63
Query: 90 STEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEV 149
T+ G ++ G N QLG G T + I C +L + +VACG ++ L +G+V
Sbjct: 64 VTDGGDLFVCGLNKDGQLGLGHT-EDIPYFTPCKSLFGCPIQQVACGWDFTIMLTENGQV 122
Query: 150 FAWGYNNCGQVGSGSTANQ-PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208
+ G N+ GQ+G + P+ + LH ++VV IA G ++A +G V+ WG
Sbjct: 123 LSCGSNSFGQLGVPHGPRRCVVPQAIE--LHKEKVVCIAAGLRHAVAATASGIVFQWG-- 178
Query: 209 GNGQLGLGNNGNQL-------------TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLY 255
GL + G +L P RV L + ++ G H+ +LTD G +Y
Sbjct: 179 ----TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVY 234
Query: 256 AWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTS-AAKTQGGHVYMWGQ 312
WG+N +GQL L P I + ++ A S T A+T+ G ++ WG+
Sbjct: 235 VWGSNKHGQL-ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGR 291
Score = 94.7 bits (234), Expect = 2e-19
Identities = 91/308 (29%), Positives = 130/308 (42%), Gaps = 47/308 (15%)
Query: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
VTD ++FV GLN LG G + + L G I+ ++ G ++L TE+G V
Sbjct: 64 VTDGGDLFVCGLNKDGQLGLGHTEDIPYFTPCKSLFGCPIQQVACGWDFTIML-TENGQV 122
Query: 97 YAWGHNGYSQLG--NGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGY 154
+ G N + QLG +G V L ++VV +A G H++A A G VF WG
Sbjct: 123 LSCGSNSFGQLGVPHGPRR---CVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGT 179
Query: 155 N--NCGQ-VGSGSTA----NQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGY 207
+CG+ + G T P +VT L + + + G S ++ D GEVY WG
Sbjct: 180 GLASCGRRLCPGQTLPLFFTAKEPSRVTG-LENSKAMCVLAGSDHSASLTDAGEVYVWGS 238
Query: 208 NGNGQLGLGNNGNQLTPV----RVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYG 263
N +GQL N PV + V I G+ H +A T+ G ++ WG YG
Sbjct: 239 NKHGQLA---NEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYG 295
Query: 264 QLG--------------------TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQ 303
QLG + N++ S H + V +C S H A
Sbjct: 296 QLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEV----SCGSEHNLA--II 349
Query: 304 GGHVYMWG 311
GG Y WG
Sbjct: 350 GGVCYSWG 357
Score = 92.0 bits (227), Expect = 1e-18
Identities = 73/245 (29%), Positives = 107/245 (43%), Gaps = 28/245 (11%)
Query: 96 VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYN 155
++AWG N Y QLG G + P Q+ + V + G HS + G++F G N
Sbjct: 17 LFAWGANSYGQLGLGHKEDVLLPQQLNDFCKPRSVRRITGGGGHSAVVTDGGDLFVCGLN 76
Query: 156 NCGQVGSGSTANQP--TPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQL 213
GQ+G G T + P TP K I++V ACG ++ + +NG+V G N GQL
Sbjct: 77 KDGQLGLGHTEDIPYFTPCKSLFGCPIQQV---ACGWDFTIMLTENGQVLSCGSNSFGQL 133
Query: 214 GLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNL 273
G+ + + + LH V I G H +A T G+++ WG G +
Sbjct: 134 GVPHGPRRCVVPQAIELHKEKVVCIAAGLRHAVAATASGIVFQWGT------GLASCGRR 187
Query: 274 LSPAHIM------VEKERVVEI----AACHSAHT--SAAKTQGGHVYMW-----GQCRGQ 316
L P + E RV + A C A + SA+ T G VY+W GQ +
Sbjct: 188 LCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDAGEVYVWGSNKHGQLANE 247
Query: 317 SVILP 321
+ LP
Sbjct: 248 AAFLP 252
Score = 87.8 bits (216), Expect = 2e-17
Identities = 77/290 (26%), Positives = 128/290 (44%), Gaps = 30/290 (10%)
Query: 35 LYVTDNDEVFVFGLNYSNCLGTGDN-QSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTED 93
+ +T+N +V G N LG + +VP+ +E L +K+ ++ G H + +T
Sbjct: 114 IMLTENGQVLSCGSNSFGQLGVPHGPRRCVVPQAIE-LHKEKVVCIAAGLR-HAVAATAS 171
Query: 94 GVVYAWGHNGYSQLGNGTTNQGIAPV-------QVCTNLLIKQVVEVACGSHHSMALAAD 146
G+V+ WG G + G P+ T L + + V GS HS +L
Sbjct: 172 GIVFQWG-TGLASCGRRLCPGQTLPLFFTAKEPSRVTGLENSKAMCVLAGSDHSASLTDA 230
Query: 147 GEVFAWGYNNCGQVGSGSTANQPTPRKV-TNCLHIKRVVGIACGQTSSMAVLDNGEVYGW 205
GEV+ WG N GQ+ + A P P+K+ +C ++V I G T +A + G+++ W
Sbjct: 231 GEVYVWGSNKHGQL-ANEAAFLPVPQKIEAHCFQNEKVTAIWSGWTHLVAQTETGKMFTW 289
Query: 206 GYNGNGQLG----------LGNNGNQLTPVR-----VAALHSVC-VNQIVCGYAHTLALT 249
G GQLG L + L R ++ H + ++ CG H LA+
Sbjct: 290 GRADYGQLGRKLETYEGWKLEKQDSFLPCSRPPNSMPSSPHCLTGATEVSCGSEHNLAII 349
Query: 250 DEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSA 299
G+ Y+WG N +G G G + N+ +P + + C + H+ A
Sbjct: 350 G-GVCYSWGWNEHGMCGDGTEANVWAPKPVQALLSSSGLLVGCGAGHSLA 398
Score = 70.1 bits (170), Expect = 5e-12
Identities = 55/200 (27%), Positives = 84/200 (42%), Gaps = 19/200 (9%)
Query: 65 PKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTN 124
P ++ GL K + GS H T+ G VY WG N + QL N +
Sbjct: 203 PSRVTGLENSKAMCVLAGSD-HSASLTDAGEVYVWGSNKHGQLANEAAFLPVPQKIEAHC 261
Query: 125 LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVG---------------SGSTANQP 169
++V + G H +A G++F WG + GQ+G S ++P
Sbjct: 262 FQNEKVTAIWSGWTHLVAQTETGKMFTWGRADYGQLGRKLETYEGWKLEKQDSFLPCSRP 321
Query: 170 TPRKVTNCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVA 228
P + + H + ++CG ++A++ G Y WG+N +G G G N P V
Sbjct: 322 -PNSMPSSPHCLTGATEVSCGSEHNLAII-GGVCYSWGWNEHGMCGDGTEANVWAPKPVQ 379
Query: 229 ALHSVCVNQIVCGYAHTLAL 248
AL S + CG H+LAL
Sbjct: 380 ALLSSSGLLVGCGAGHSLAL 399
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 102 bits (254), Expect = 9e-22
Identities = 75/273 (27%), Positives = 122/273 (44%), Gaps = 19/273 (6%)
Query: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVV 96
+TD + FG + CLG G P +E L G ++ ++ G+ HVL + + +
Sbjct: 406 LTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGAS-HVLALSTEREL 464
Query: 97 YAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNN 156
+AWG +LG GT P QV ++ V CG SM L G+ A G N
Sbjct: 465 FAWGRGDSGRLGLGTRESHSCPQQVPMPPG-QEAQRVVCGIDSSMILTVPGQALACGSNR 523
Query: 157 CGQVGSG--STANQPTP-RKVTNCLHI----------KRVVGIACGQTSSMAVLDNGEVY 203
++G S +P P ++V L + ++ I G S AV +G+ Y
Sbjct: 524 FNKLGLDHLSLGEEPVPHQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCY 583
Query: 204 GWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYG 263
+G N +GQLG P +V L + + + CG A T+A+ E +Y+WG G
Sbjct: 584 TFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARG 643
Query: 264 QLGTGNKNNLLSPAHIMVEKER---VVEIAACH 293
+LG +++ L P + +++ V ++ CH
Sbjct: 644 RLGRRDEDAGL-PRPVQLDETHPYTVTSVSCCH 675
Score = 99.0 bits (245), Expect = 1e-20
Identities = 80/269 (29%), Positives = 127/269 (47%), Gaps = 22/269 (8%)
Query: 60 QSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPV 119
Q + + LEG G IK ++ G L T+ G++ +G LG+G+ I+
Sbjct: 377 QPQFISRFLEGQSGVTIKHVACGDFFTACL-TDRGIIMTFGSGSNGCLGHGSLTD-ISQP 434
Query: 120 QVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNC-- 177
+ LL ++V+VACG+ H +AL+ + E+FAWG + G++G G+ + P++V
Sbjct: 435 TIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPG 494
Query: 178 LHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPV---------RVA 228
+RVV CG SSM + G+ G N +LGL + PV
Sbjct: 495 QEAQRVV---CGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVEEALSFT 551
Query: 229 ALHSVCVNQ-----IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEK 283
L S ++Q I G AH+ A+T G Y +G+N +GQLGT + +P + +
Sbjct: 552 LLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLE 611
Query: 284 ERVVEIAACHSAHTSAAKTQGGHVYMWGQ 312
+ + AC A T A + VY WG+
Sbjct: 612 GIKMAMVACGDAFTVAIGAE-SEVYSWGK 639
Score = 82.8 bits (203), Expect = 7e-16
Identities = 73/269 (27%), Positives = 122/269 (45%), Gaps = 26/269 (9%)
Query: 1 MVDVGKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQ 60
+ D+ + I L E+ + AC AS L ++ E+F +G S LG G +
Sbjct: 428 LTDISQPTIVEALLGYEMVQV--AC----GASHVLALSTERELFAWGRGDSGRLGLGTRE 481
Query: 61 STLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPV- 119
S P+++ G++ + + G ++L T G A G N +++LG + G PV
Sbjct: 482 SHSCPQQVPMPPGQEAQRVVCGIDSSMIL-TVPGQALACGSNRFNKLGLDHLSLGEEPVP 540
Query: 120 --QVCTNLLI----------KQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTAN 167
QV L + ++ + G+ HS A+ A G+ + +G N GQ+G+ +
Sbjct: 541 HQQVEEALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG 600
Query: 168 QPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQL-TPVR 226
P KV IK + +ACG ++A+ EVY WG G+LG + L PV+
Sbjct: 601 SRAPCKVQGLEGIKMAM-VACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPVQ 659
Query: 227 VAALHSVCVNQIVCGYAHTL----ALTDE 251
+ H V + C + +TL ++TDE
Sbjct: 660 LDETHPYTVTSVSCCHGNTLLAVRSVTDE 688
Score = 77.8 bits (190), Expect = 2e-14
Identities = 68/236 (28%), Positives = 101/236 (42%), Gaps = 23/236 (9%)
Query: 96 VYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYN 155
VYAWG G GT P+++ +L +VV+VA G + G + W
Sbjct: 314 VYAWGG------GLGT------PLRL--PMLNTEVVQVAAGRTQKAGVTRSGRLILWEAP 359
Query: 156 NCGQVGSGS----TANQPTPRKVTNCLHIKRVVGI---ACGQTSSMAVLDNGEVYGWGYN 208
G G GS QP P+ ++ L + V I ACG + + D G + +G
Sbjct: 360 PLG-AGGGSLLPGAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSG 418
Query: 209 GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268
NG LG G+ + P V AL + Q+ CG +H LAL+ E L+AWG G+LG G
Sbjct: 419 SNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGLG 478
Query: 269 NKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVILPHLT 324
+ + P + + + + C +S T G G R + L HL+
Sbjct: 479 TRESHSCPQQVPMPPGQEAQRVVC-GIDSSMILTVPGQALACGSNRFNKLGLDHLS 533
>gi|222136641 NIMA-related kinase 9 [Homo sapiens]
Length = 979
Score = 98.6 bits (244), Expect = 1e-20
Identities = 89/317 (28%), Positives = 143/317 (45%), Gaps = 36/317 (11%)
Query: 20 SIRKACVFGTSASEALYVTDNDEVFVF-----GLNYSNCLGTGDNQSTLVPKKLEGLCGK 74
S R+ C T + VT E++ + G LG GD S PK +E L GK
Sbjct: 370 SARQVCAGNTHFA---VVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEKLQGK 426
Query: 75 KIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTN--QGIAPVQVCTNLLIKQVVE 132
I+ +S G V + T++G +YA+G + Y +G + + P+Q+ N + VE
Sbjct: 427 AIRQVSCGDDFTVCV-TDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQL--NFFLSNPVE 483
Query: 133 -VACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQT 191
V+CG +H + L + EV++WG G++G S + TP+KV + +V + CG
Sbjct: 484 QVSCGDNHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKV-DVPKALIIVAVQCGCD 542
Query: 192 SSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVC---------------VN 236
+ + +G+V G N +LGL + + + A H V +
Sbjct: 543 GTFLLTQSGKVLACGLNEFNKLGLNQCMSGI--INHEAYHEVPYTTSFTLAKQLSFYKIR 600
Query: 237 QIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI--MVEKERVVEIAACHS 294
I G HT A+ + G L +G N GQLG GN L + + ++V+ + +C
Sbjct: 601 TIAPGKTHTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRV-SCGD 659
Query: 295 AHTSAAKTQGGHVYMWG 311
T AA T H++ WG
Sbjct: 660 EFTIAA-TDDNHIFAWG 675
Score = 87.8 bits (216), Expect = 2e-17
Identities = 70/245 (28%), Positives = 112/245 (45%), Gaps = 19/245 (7%)
Query: 37 VTDNDEVFVFGLNYSNCLGTGD--NQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDG 94
VTD +++ FG +Y C+G L P +L ++ +S G HV++ T +
Sbjct: 441 VTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDN-HVVVLTRNK 499
Query: 95 VVYAWGHNGYSQLGNGTTNQGIAPVQV-CTNLLIKQVVEVACGSHHSMALAADGEVFAWG 153
VY+WG Y +LG + P +V LI +V V CG + L G+V A G
Sbjct: 500 EVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALI--IVAVQCGCDGTFLLTQSGKVLACG 557
Query: 154 YNNCGQVG-----SGSTANQP-------TPRKVTNCLHIKRVVGIACGQTSSMAVLDNGE 201
N ++G SG ++ T + L ++ IA G+T + A+ + G
Sbjct: 558 LNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTHTAAIDERGR 617
Query: 202 VYGWGYNGNGQLGLGNNGNQL-TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGAN 260
+ +G N GQLG+GN +L + L V ++ CG T+A TD+ ++AWG
Sbjct: 618 LLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDDNHIFAWGNG 677
Query: 261 TYGQL 265
G+L
Sbjct: 678 GNGRL 682
Score = 83.2 bits (204), Expect = 5e-16
Identities = 61/245 (24%), Positives = 104/245 (42%), Gaps = 21/245 (8%)
Query: 74 KKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEV 133
K+ +S + P ++++ VY WG + G + QVC
Sbjct: 327 KRPRSSTVTEAPIAVVTSRTSEVYVWGGGKSTPQKLDVIKSGCSARQVCA---------- 376
Query: 134 ACGSHHSMALAADGEVFAW-----GYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIAC 188
G+ H + + E++ W G GQ+G G A+ P+ V L K + ++C
Sbjct: 377 --GNTHFAVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHVEK-LQGKAIRQVSC 433
Query: 189 GQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQ--LTPVRVAALHSVCVNQIVCGYAHTL 246
G ++ V D G++Y +G + G +G+ L P+++ S V Q+ CG H +
Sbjct: 434 GDDFTVCVTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVV 493
Query: 247 ALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGH 306
LT +Y+WG YG+LG ++ + +P + V K ++ C T TQ G
Sbjct: 494 VLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL-TQSGK 552
Query: 307 VYMWG 311
V G
Sbjct: 553 VLACG 557
Score = 75.9 bits (185), Expect = 9e-14
Identities = 63/245 (25%), Positives = 107/245 (43%), Gaps = 21/245 (8%)
Query: 29 TSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGL-CGKKIKSLSYGSGPHV 87
T A A+ + EV+V+G S P+KL+ + G + + G+ H
Sbjct: 335 TEAPIAVVTSRTSEVYVWGGGKST------------PQKLDVIKSGCSARQVCAGN-THF 381
Query: 88 LLSTEDGVVYAW-----GHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMA 142
+ T + +Y W G + QLG+G P V L K + +V+CG ++
Sbjct: 382 AVVTVEKELYTWVNMQGGTKLHGQLGHGDKASYRQPKHV-EKLQGKAIRQVSCGDDFTVC 440
Query: 143 LAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT-NCLHIKRVVGIACGQTSSMAVLDNGE 201
+ +G+++A+G + G +G A + N V ++CG + + N E
Sbjct: 441 VTDEGQLYAFGSDYYGCMGVDKVAGPEVLEPMQLNFFLSNPVEQVSCGDNHVVVLTRNKE 500
Query: 202 VYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANT 261
VY WG G+LGL + + TP +V ++ + + CG T LT G + A G N
Sbjct: 501 VYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLLTQSGKVLACGLNE 560
Query: 262 YGQLG 266
+ +LG
Sbjct: 561 FNKLG 565
Score = 71.6 bits (174), Expect = 2e-12
Identities = 49/196 (25%), Positives = 87/196 (44%), Gaps = 13/196 (6%)
Query: 32 SEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLST 91
+ + +T N EV+ +G LG + P+K++ I ++ G LL T
Sbjct: 490 NHVVVLTRNKEVYSWGCGEYGRLGLDSEEDYYTPQKVDVPKALIIVAVQCGCDGTFLL-T 548
Query: 92 EDGVVYAWGHNGYSQLGNGTTNQGI------------APVQVCTNLLIKQVVEVACGSHH 139
+ G V A G N +++LG GI + L ++ +A G H
Sbjct: 549 QSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGKTH 608
Query: 140 SMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDN 199
+ A+ G + +G N CGQ+G G+ + + L K+V+ ++CG ++A D+
Sbjct: 609 TAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAATDD 668
Query: 200 GEVYGWGYNGNGQLGL 215
++ WG GNG+L +
Sbjct: 669 NHIFAWGNGGNGRLAM 684
Score = 47.4 bits (111), Expect = 3e-05
Identities = 41/149 (27%), Positives = 63/149 (42%), Gaps = 19/149 (12%)
Query: 37 VTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKL-------------EGLCGKKIKSLSYGS 83
+T + +V GLN N LG S ++ + + L KI++++ G
Sbjct: 547 LTQSGKVLACGLNEFNKLGLNQCMSGIINHEAYHEVPYTTSFTLAKQLSFYKIRTIAPGK 606
Query: 84 GPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMAL 143
H E G + +G N QLG G + + + L KQV+ V+CG ++A
Sbjct: 607 -THTAAIDERGRLLTFGCNKCGQLGVGNYKKRLGINLLGGPLGGKQVIRVSCGDEFTIAA 665
Query: 144 AADGEVFAWGYNNCGQVGSGSTANQPTPR 172
D +FAWG G+G A PT R
Sbjct: 666 TDDNHIFAWGNG-----GNGRLAMTPTER 689
>gi|13540582 Williams-Beuren syndrome chromosome region 16 [Homo
sapiens]
Length = 464
Score = 92.8 bits (229), Expect = 7e-19
Identities = 81/289 (28%), Positives = 133/289 (46%), Gaps = 29/289 (10%)
Query: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPK-----KLE 69
PQE ++ +C + +L +TD + VF G N G ++ + + +++
Sbjct: 171 PQETRVLQVSC----GRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQ 226
Query: 70 GLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQ 129
G+ ++ ++ G H L T+ G VY+ G Q G G N +P ++ +L
Sbjct: 227 DFDGQVVQ-VACGQD-HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVN 284
Query: 130 VVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGI 186
V++VA +A++ADG +F WG + Q+ S + + Q V CLH + +V
Sbjct: 285 VIQVATYGDCCLAVSADGGLFGWGNSEYLQLASVTDSTQV---NVPRCLHFSGVGKVRQA 341
Query: 187 ACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNN-----GNQLTPVRVAAL----HSVCVNQ 237
ACG T + G V+ WGY G LG G N ++ P + L + V++
Sbjct: 342 ACGGTGCAVLNGEGHVFVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSR 398
Query: 238 IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERV 286
I CG +H ALT++G L+ WG N G LG G + P + + E V
Sbjct: 399 IRCGLSHFAALTNKGELFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV 447
Score = 57.4 bits (137), Expect = 3e-08
Identities = 45/159 (28%), Positives = 67/159 (42%), Gaps = 13/159 (8%)
Query: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPV--RVAALHSVC--VNQ 237
RV+ ++CG+ S+ + D V+ G N GQ G N++ RV + V Q
Sbjct: 175 RVLQVSCGRAHSLVLTDREGVFSMGNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQ 234
Query: 238 IVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAHT 297
+ CG H+L LTD+G +Y+ G GQ G G+ N SP + + V I
Sbjct: 235 VACGQDHSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDC 294
Query: 298 SAAKTQGGHVYMWGQCR---------GQSVILPHLTHFS 327
A + G ++ WG V +P HFS
Sbjct: 295 CLAVSADGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFS 333
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 89.4 bits (220), Expect = 8e-18
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%)
Query: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71
P ++ K S +TD+ VF++G N G + ++VP +++
Sbjct: 129 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 186
Query: 72 CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123
+ + SG H+++ T DG +Y G QLG N QG+ + V
Sbjct: 187 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 244
Query: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
+++K + + CG++ + A++ +G V+ +G +N Q+G+ T + P+ +T
Sbjct: 245 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 304
Query: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233
+ + K VG + GQ ++ + G+ Y G G+LGLG + + P ++ L +V
Sbjct: 305 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 364
Query: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291
+ + CG + A+T +G ++AWG T QLGTG + SP +M + + RVV +
Sbjct: 365 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 422
Query: 292 CHSAHT 297
HT
Sbjct: 423 SGGQHT 428
Score = 70.5 bits (171), Expect = 4e-12
Identities = 70/243 (28%), Positives = 114/243 (46%), Gaps = 29/243 (11%)
Query: 90 STEDGVVYAWGHNGYSQLGNG-TTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGE 148
STE G+V G QLG G + P V + + VV+ G H++ L+ G+
Sbjct: 48 STEPGLVLTLGQGDVGQLGLGENVMERKKPALVS---IPEDVVQAEAGGMHTVCLSKSGQ 104
Query: 149 VFAWGYNNCGQVGSGST--ANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWG 206
V+++G N+ G +G ++ ++ P KV ++VV ++ G + + A+ D+G V+ WG
Sbjct: 105 VYSFGCNDEGALGRDTSVEGSEMVPGKVE---LQEKVVQVSAGDSHTAALTDDGRVFLWG 161
Query: 207 --YNGNGQLG-LGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYG 263
+ NG +G L + PV+V V V ++ G H + LT +G LY G G
Sbjct: 162 SFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVASGNDHLVMLTADGDLYTLGCGEQG 219
Query: 264 QLGT-----GNK------NNLLSPAHIMVE----KERVVEIAACHSAHTSAAKTQGGHVY 308
QLG N+ LL P +M++ + V A A+ + A + GHVY
Sbjct: 220 QLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVY 279
Query: 309 MWG 311
+G
Sbjct: 280 GFG 282
Score = 69.7 bits (169), Expect = 6e-12
Identities = 63/215 (29%), Positives = 96/215 (44%), Gaps = 23/215 (10%)
Query: 84 GPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMAL 143
G H + ++ G VY++G N LG T+ +G V L ++VV+V+ G H+ AL
Sbjct: 93 GMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAAL 151
Query: 144 AADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRVVGIACGQTSSMAVLDNG 200
DG VF WG +N G +G + P +V L + VV +A G + + +G
Sbjct: 152 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-VVKVASGNDHLVMLTADG 208
Query: 201 EVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV-----AALHSVCVNQIVCGYAH 244
++Y G GQLG N G + L P V + V CG
Sbjct: 209 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYF 268
Query: 245 TLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279
T A++ EG +Y +G + Y QLGT + P ++
Sbjct: 269 TFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 303
Score = 55.5 bits (132), Expect = 1e-07
Identities = 49/157 (31%), Positives = 77/157 (49%), Gaps = 9/157 (5%)
Query: 169 PTPRKV--TNCLHIKRVVGIACGQTSSMA-VLDNGEVYGWGYNGNGQLGLGNNGNQLTPV 225
P +KV T +RV G Q S + + G V G GQLGLG N +
Sbjct: 18 PKSKKVKDTRAAASRRVPGARSCQVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 77
Query: 226 RVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG--TGNKNNLLSPAHIMVEK 283
+ ++ V Q G HT+ L+ G +Y++G N G LG T + + + P + ++
Sbjct: 78 ALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ- 135
Query: 284 ERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQSVIL 320
E+VV+++A S HT AA T G V++WG R + ++
Sbjct: 136 EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNNGVI 170
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 89.4 bits (220), Expect = 8e-18
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%)
Query: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71
P ++ K S +TD+ VF++G N G + ++VP +++
Sbjct: 143 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 200
Query: 72 CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123
+ + SG H+++ T DG +Y G QLG N QG+ + V
Sbjct: 201 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 258
Query: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
+++K + + CG++ + A++ +G V+ +G +N Q+G+ T + P+ +T
Sbjct: 259 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 318
Query: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233
+ + K VG + GQ ++ + G+ Y G G+LGLG + + P ++ L +V
Sbjct: 319 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 378
Query: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291
+ + CG + A+T +G ++AWG T QLGTG + SP +M + + RVV +
Sbjct: 379 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 436
Query: 292 CHSAHT 297
HT
Sbjct: 437 SGGQHT 442
Score = 73.2 bits (178), Expect = 6e-13
Identities = 74/267 (27%), Positives = 120/267 (44%), Gaps = 29/267 (10%)
Query: 66 KKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNG-TTNQGIAPVQVCTN 124
+ +G CG H STE G+V G QLG G + P V
Sbjct: 38 RSCQGACGPSPPDQKTRPVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALVS-- 95
Query: 125 LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGST--ANQPTPRKVTNCLHIKR 182
+ + VV+ G H++ L+ G+V+++G N+ G +G ++ ++ P KV ++
Sbjct: 96 -IPEDVVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVE---LQEK 151
Query: 183 VVGIACGQTSSMAVLDNGEVYGWG--YNGNGQLG-LGNNGNQLTPVRVAALHSVCVNQIV 239
VV ++ G + + A+ D+G V+ WG + NG +G L + PV+V V V ++
Sbjct: 152 VVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQL--DVPVVKVA 209
Query: 240 CGYAHTLALTDEGLLYAWGANTYGQLGT-----GNK------NNLLSPAHIMVE----KE 284
G H + LT +G LY G GQLG N+ LL P +M++ +
Sbjct: 210 SGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRG 269
Query: 285 RVVEIAACHSAHTSAAKTQGGHVYMWG 311
V A A+ + A + GHVY +G
Sbjct: 270 HVRFQDAFCGAYFTFAISHEGHVYGFG 296
Score = 69.7 bits (169), Expect = 6e-12
Identities = 63/215 (29%), Positives = 96/215 (44%), Gaps = 23/215 (10%)
Query: 84 GPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMAL 143
G H + ++ G VY++G N LG T+ +G V L ++VV+V+ G H+ AL
Sbjct: 107 GMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDSHTAAL 165
Query: 144 AADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRVVGIACGQTSSMAVLDNG 200
DG VF WG +N G +G + P +V L + VV +A G + + +G
Sbjct: 166 TDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-VVKVASGNDHLVMLTADG 222
Query: 201 EVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV-----AALHSVCVNQIVCGYAH 244
++Y G GQLG N G + L P V + V CG
Sbjct: 223 DLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYF 282
Query: 245 TLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279
T A++ EG +Y +G + Y QLGT + P ++
Sbjct: 283 TFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 317
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/123 (32%), Positives = 64/123 (52%), Gaps = 6/123 (4%)
Query: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259
G V G GQLGLG N + + ++ V Q G HT+ L+ G +Y++G
Sbjct: 66 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGC 124
Query: 260 NTYGQLG--TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQS 317
N G LG T + + + P + ++ E+VV+++A S HT AA T G V++WG R +
Sbjct: 125 NDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNN 181
Query: 318 VIL 320
++
Sbjct: 182 GVI 184
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 89.4 bits (220), Expect = 8e-18
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%)
Query: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71
P ++ K S +TD+ VF++G N G + ++VP +++
Sbjct: 112 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 169
Query: 72 CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123
+ + SG H+++ T DG +Y G QLG N QG+ + V
Sbjct: 170 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
+++K + + CG++ + A++ +G V+ +G +N Q+G+ T + P+ +T
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
Query: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233
+ + K VG + GQ ++ + G+ Y G G+LGLG + + P ++ L +V
Sbjct: 288 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 347
Query: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291
+ + CG + A+T +G ++AWG T QLGTG + SP +M + + RVV +
Sbjct: 348 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 405
Query: 292 CHSAHT 297
HT
Sbjct: 406 SGGQHT 411
Score = 70.9 bits (172), Expect = 3e-12
Identities = 78/292 (26%), Positives = 122/292 (41%), Gaps = 31/292 (10%)
Query: 13 LSPQEIASIRKACVFGTSASEALYV------TDNDEVFVFGLNYSNCLGTGDNQSTLVPK 66
+SP+ IA R S+ + V T+ V G LG G+N
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60
Query: 67 KLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126
L + +++ + G H + ++ G VY++G N LG T+ +G V L
Sbjct: 61 ALVSIPEDVVQAEA--GGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ 118
Query: 127 IKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRV 183
++VV+V+ G H+ AL DG VF WG +N G +G + P +V L + V
Sbjct: 119 -EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-V 174
Query: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV----- 227
V +A G + + +G++Y G GQLG N G + L P V
Sbjct: 175 VKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSR 234
Query: 228 AALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279
+ V CG T A++ EG +Y +G + Y QLGT + P ++
Sbjct: 235 GSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 286
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/123 (32%), Positives = 64/123 (52%), Gaps = 6/123 (4%)
Query: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259
G V G GQLGLG N + + ++ V Q G HT+ L+ G +Y++G
Sbjct: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGC 93
Query: 260 NTYGQLG--TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQS 317
N G LG T + + + P + ++ E+VV+++A S HT AA T G V++WG R +
Sbjct: 94 NDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNN 150
Query: 318 VIL 320
++
Sbjct: 151 GVI 153
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 89.4 bits (220), Expect = 8e-18
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%)
Query: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71
P ++ K S +TD+ VF++G N G + ++VP +++
Sbjct: 112 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 169
Query: 72 CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123
+ + SG H+++ T DG +Y G QLG N QG+ + V
Sbjct: 170 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
+++K + + CG++ + A++ +G V+ +G +N Q+G+ T + P+ +T
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
Query: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233
+ + K VG + GQ ++ + G+ Y G G+LGLG + + P ++ L +V
Sbjct: 288 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 347
Query: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291
+ + CG + A+T +G ++AWG T QLGTG + SP +M + + RVV +
Sbjct: 348 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 405
Query: 292 CHSAHT 297
HT
Sbjct: 406 SGGQHT 411
Score = 70.9 bits (172), Expect = 3e-12
Identities = 78/292 (26%), Positives = 122/292 (41%), Gaps = 31/292 (10%)
Query: 13 LSPQEIASIRKACVFGTSASEALYV------TDNDEVFVFGLNYSNCLGTGDNQSTLVPK 66
+SP+ IA R S+ + V T+ V G LG G+N
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60
Query: 67 KLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126
L + +++ + G H + ++ G VY++G N LG T+ +G V L
Sbjct: 61 ALVSIPEDVVQAEA--GGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ 118
Query: 127 IKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRV 183
++VV+V+ G H+ AL DG VF WG +N G +G + P +V L + V
Sbjct: 119 -EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-V 174
Query: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV----- 227
V +A G + + +G++Y G GQLG N G + L P V
Sbjct: 175 VKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSR 234
Query: 228 AALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279
+ V CG T A++ EG +Y +G + Y QLGT + P ++
Sbjct: 235 GSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 286
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/123 (32%), Positives = 64/123 (52%), Gaps = 6/123 (4%)
Query: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259
G V G GQLGLG N + + ++ V Q G HT+ L+ G +Y++G
Sbjct: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGC 93
Query: 260 NTYGQLG--TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQS 317
N G LG T + + + P + ++ E+VV+++A S HT AA T G V++WG R +
Sbjct: 94 NDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNN 150
Query: 318 VIL 320
++
Sbjct: 151 GVI 153
>gi|114796640 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 89.4 bits (220), Expect = 8e-18
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%)
Query: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71
P ++ K S +TD+ VF++G N G + ++VP +++
Sbjct: 112 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 169
Query: 72 CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123
+ + SG H+++ T DG +Y G QLG N QG+ + V
Sbjct: 170 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
+++K + + CG++ + A++ +G V+ +G +N Q+G+ T + P+ +T
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
Query: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233
+ + K VG + GQ ++ + G+ Y G G+LGLG + + P ++ L +V
Sbjct: 288 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 347
Query: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291
+ + CG + A+T +G ++AWG T QLGTG + SP +M + + RVV +
Sbjct: 348 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 405
Query: 292 CHSAHT 297
HT
Sbjct: 406 SGGQHT 411
Score = 70.9 bits (172), Expect = 3e-12
Identities = 78/292 (26%), Positives = 122/292 (41%), Gaps = 31/292 (10%)
Query: 13 LSPQEIASIRKACVFGTSASEALYV------TDNDEVFVFGLNYSNCLGTGDNQSTLVPK 66
+SP+ IA R S+ + V T+ V G LG G+N
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60
Query: 67 KLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126
L + +++ + G H + ++ G VY++G N LG T+ +G V L
Sbjct: 61 ALVSIPEDVVQAEA--GGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ 118
Query: 127 IKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRV 183
++VV+V+ G H+ AL DG VF WG +N G +G + P +V L + V
Sbjct: 119 -EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-V 174
Query: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV----- 227
V +A G + + +G++Y G GQLG N G + L P V
Sbjct: 175 VKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSR 234
Query: 228 AALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279
+ V CG T A++ EG +Y +G + Y QLGT + P ++
Sbjct: 235 GSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 286
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/123 (32%), Positives = 64/123 (52%), Gaps = 6/123 (4%)
Query: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259
G V G GQLGLG N + + ++ V Q G HT+ L+ G +Y++G
Sbjct: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGC 93
Query: 260 NTYGQLG--TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQS 317
N G LG T + + + P + ++ E+VV+++A S HT AA T G V++WG R +
Sbjct: 94 NDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNN 150
Query: 318 VIL 320
++
Sbjct: 151 GVI 153
>gi|114796648 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 89.4 bits (220), Expect = 8e-18
Identities = 78/306 (25%), Positives = 142/306 (46%), Gaps = 29/306 (9%)
Query: 15 PQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTG---DNQSTLVPKKLEGL 71
P ++ K S +TD+ VF++G N G + ++VP +++
Sbjct: 112 PGKVELQEKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ-- 169
Query: 72 CGKKIKSLSYGSG-PHVLLSTEDGVVYAWGHNGYSQLG-------NGTTNQGIAPVQVCT 123
+ + SG H+++ T DG +Y G QLG N QG+ + V
Sbjct: 170 --LDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPK 227
Query: 124 NLLIK--------QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
+++K + + CG++ + A++ +G V+ +G +N Q+G+ T + P+ +T
Sbjct: 228 CVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNLT 287
Query: 176 NCLH-IKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVAALHSV 233
+ + K VG + GQ ++ + G+ Y G G+LGLG + + P ++ L +V
Sbjct: 288 SFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAV 347
Query: 234 CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVE--KERVVEIAA 291
+ + CG + A+T +G ++AWG T QLGTG + SP +M + + RVV +
Sbjct: 348 --SSVACGASVGYAVTKDGRVFAWGMGTNYQLGTGQDEDAWSPVEMMGKQLENRVVLSVS 405
Query: 292 CHSAHT 297
HT
Sbjct: 406 SGGQHT 411
Score = 70.9 bits (172), Expect = 3e-12
Identities = 78/292 (26%), Positives = 122/292 (41%), Gaps = 31/292 (10%)
Query: 13 LSPQEIASIRKACVFGTSASEALYV------TDNDEVFVFGLNYSNCLGTGDNQSTLVPK 66
+SP+ IA R S+ + V T+ V G LG G+N
Sbjct: 1 MSPKRIAKRRSPPADAIPKSKKVKVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKP 60
Query: 67 KLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLL 126
L + +++ + G H + ++ G VY++G N LG T+ +G V L
Sbjct: 61 ALVSIPEDVVQAEA--GGMHTVCLSKSGQVYSFGCNDEGALGRDTSVEGSEMVPGKVELQ 118
Query: 127 IKQVVEVACGSHHSMALAADGEVFAWG--YNNCGQVGSGSTANQP-TPRKVTNCLHIKRV 183
++VV+V+ G H+ AL DG VF WG +N G +G + P +V L + V
Sbjct: 119 -EKVVQVSAGDSHTAALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQ--LDVP-V 174
Query: 184 VGIACGQTSSMAVLDNGEVYGWGYNGNGQLG-----LGNNGNQ------LTPVRV----- 227
V +A G + + +G++Y G GQLG N G + L P V
Sbjct: 175 VKVASGNDHLVMLTADGDLYTLGCGEQGQLGRVPELFANRGGRQGLERLLVPKCVMLKSR 234
Query: 228 AALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI 279
+ V CG T A++ EG +Y +G + Y QLGT + P ++
Sbjct: 235 GSRGHVRFQDAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESCFIPQNL 286
Score = 53.5 bits (127), Expect = 5e-07
Identities = 40/123 (32%), Positives = 64/123 (52%), Gaps = 6/123 (4%)
Query: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259
G V G GQLGLG N + + ++ V Q G HT+ L+ G +Y++G
Sbjct: 35 GLVLTLGQGDVGQLGLGENVMERKKPALVSIPEDVV-QAEAGGMHTVCLSKSGQVYSFGC 93
Query: 260 NTYGQLG--TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKTQGGHVYMWGQCRGQS 317
N G LG T + + + P + ++ E+VV+++A S HT AA T G V++WG R +
Sbjct: 94 NDEGALGRDTSVEGSEMVPGKVELQ-EKVVQVSAGDS-HT-AALTDDGRVFLWGSFRDNN 150
Query: 318 VIL 320
++
Sbjct: 151 GVI 153
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 85.9 bits (211), Expect = 8e-17
Identities = 49/156 (31%), Positives = 81/156 (51%), Gaps = 2/156 (1%)
Query: 94 GVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG 153
G+V++WG + +LG G ++G Q L + V ++ CG+ +AL G V+ WG
Sbjct: 675 GLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 733
Query: 154 YNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQL 213
+ ++G S + P +V L K++V +A G +AV+D+G+VY WG N +GQ
Sbjct: 734 KGDYFRLGHRSDVHVRKP-QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 792
Query: 214 GLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALT 249
G G P+ V L + + CG +H++A T
Sbjct: 793 GNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 828
Score = 82.8 bits (203), Expect = 7e-16
Identities = 50/153 (32%), Positives = 85/153 (55%), Gaps = 3/153 (1%)
Query: 43 VFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN 102
VF +G LG G ++ +P+ +E L G+ + + G+ +L T+ GVV+ WG
Sbjct: 677 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA-QFLLALTKSGVVWTWGKG 735
Query: 103 GYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGS 162
Y +LG+ ++ + QV L K++V VA G+ H +A+ G+V+AWG N+ GQ G+
Sbjct: 736 DYFRLGH-RSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 794
Query: 163 GSTANQPTPRKVTNCLHIKRVVGIACGQTSSMA 195
G+T P V L ++++ +ACG + S+A
Sbjct: 795 GTTTVNRKPMLVQG-LEGQKIMCVACGSSHSVA 826
Score = 74.3 bits (181), Expect = 3e-13
Identities = 46/156 (29%), Positives = 74/156 (47%), Gaps = 1/156 (0%)
Query: 147 GEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWG 206
G VF+WG + G++G G + P+ + L+ + V I CG +A+ +G V+ WG
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFLLALTKSGVVWTWG 733
Query: 207 YNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266
+LG ++ + P V L + + G H LA+ D G +YAWG N +GQ G
Sbjct: 734 KGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 793
Query: 267 TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKT 302
G P + + + + AC S+H+ A T
Sbjct: 794 NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTT 829
Score = 64.7 bits (156), Expect = 2e-10
Identities = 46/130 (35%), Positives = 66/130 (50%), Gaps = 4/130 (3%)
Query: 15 PQEIASI--RKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72
PQ I + + C A L +T + V+ +G LG + P+ +EGL
Sbjct: 699 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLR 758
Query: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE 132
GKKI ++ G+ H L + G VYAWG N + Q GNGTT P+ V L ++++
Sbjct: 759 GKKIVHVAVGA-QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLV-QGLEGQKIMC 816
Query: 133 VACGSHHSMA 142
VACGS HS+A
Sbjct: 817 VACGSSHSVA 826
Score = 56.6 bits (135), Expect = 5e-08
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 3/113 (2%)
Query: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259
G V+ WG G+LG G + P + L+ V QI CG LALT G+++ WG
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 734
Query: 260 NTYGQLGTGNKNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Y +LG + ++ P + + +++V +A A A G VY WG
Sbjct: 735 GDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAV--GAQHCLAVMDSGQVYAWG 785
Score = 34.7 bits (78), Expect = 0.22
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 15 PQEIASIR--KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72
PQ + +R K A L V D+ +V+ +G N G G P ++GL
Sbjct: 751 PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLE 810
Query: 73 GKKIKSLSYGSGPHVLLSTED 93
G+KI ++ GS V +T D
Sbjct: 811 GQKIMCVACGSSHSVAWTTMD 831
>gi|169171160 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 85.9 bits (211), Expect = 8e-17
Identities = 66/213 (30%), Positives = 99/213 (46%), Gaps = 18/213 (8%)
Query: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145
H L T+ G VY+ G Q G G N +P ++ +L V++VA +A++A
Sbjct: 44 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 103
Query: 146 DGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGIACGQTSSMAVLDNGEV 202
DG +F WG + Q+ S + + Q V CLH + +V ACG T + G V
Sbjct: 104 DGGLFGWGNSEYLQLASVTDSTQV---NVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHV 160
Query: 203 YGWGYNGNGQLGLGNN-----GNQLTPVRVAAL----HSVCVNQIVCGYAHTLALTDEGL 253
+ WGY G LG G N ++ P + L + V++I CG + ALT++G
Sbjct: 161 FVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGE 217
Query: 254 LYAWGANTYGQLGTGNKNNLLSPAHIMVEKERV 286
L+ WG N G LG G + P + + E V
Sbjct: 218 LFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV 250
Score = 77.0 bits (188), Expect = 4e-14
Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 15/224 (6%)
Query: 34 ALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG-LCGKKIKSLSYGSGPHVLLSTE 92
+L++TD EV+ G G G T P KL G L G + ++ G L +
Sbjct: 45 SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVA-TYGDCCLAVSA 103
Query: 93 DGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAW 152
DG ++ WG++ Y QL + T + + + + +V + ACG L +G VF W
Sbjct: 104 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 163
Query: 153 GYNNCGQVGSGSTANQ--------PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204
GY G +G G + PT +T +V I CG + A+ + GE++
Sbjct: 164 GY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFV 220
Query: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLAL 248
WG N G LG+G +Q P RV + CG H + L
Sbjct: 221 WGKNIRGCLGIGRLEDQYFPWRVTMPGEPV--DVACGVDHMVTL 262
Score = 73.2 bits (178), Expect = 6e-13
Identities = 64/225 (28%), Positives = 95/225 (42%), Gaps = 15/225 (6%)
Query: 100 GHNGYSQLGNGTTNQGIAPVQVCTNLLIK---QVVEVACGSHHSMALAADGEVFAWGYNN 156
G+N Y Q G I + + QVV+VACG HS+ L GEV++ G+
Sbjct: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
Query: 157 CGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLG 216
GQ G G +P K+ L V+ +A +AV +G ++GWG + QL
Sbjct: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASV 121
Query: 217 NNGNQLTPVRVAALHSV-CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG-NKNNLL 274
+ Q+ R V V Q CG L EG ++ WG YG LG G N
Sbjct: 122 TDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESA 178
Query: 275 SPAHI------MVEKERVVEIAACHSAHTS-AAKTQGGHVYMWGQ 312
P I + E ++++ + AA T G +++WG+
Sbjct: 179 VPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
>gi|169170558 PREDICTED: RCC1-like G exchanging factor-like [Homo
sapiens]
Length = 267
Score = 85.9 bits (211), Expect = 8e-17
Identities = 66/213 (30%), Positives = 99/213 (46%), Gaps = 18/213 (8%)
Query: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145
H L T+ G VY+ G Q G G N +P ++ +L V++VA +A++A
Sbjct: 44 HSLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSA 103
Query: 146 DGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLH---IKRVVGIACGQTSSMAVLDNGEV 202
DG +F WG + Q+ S + + Q V CLH + +V ACG T + G V
Sbjct: 104 DGGLFGWGNSEYLQLASVTDSTQV---NVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHV 160
Query: 203 YGWGYNGNGQLGLGNN-----GNQLTPVRVAAL----HSVCVNQIVCGYAHTLALTDEGL 253
+ WGY G LG G N ++ P + L + V++I CG + ALT++G
Sbjct: 161 FVWGY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGE 217
Query: 254 LYAWGANTYGQLGTGNKNNLLSPAHIMVEKERV 286
L+ WG N G LG G + P + + E V
Sbjct: 218 LFVWGKNIRGCLGIGRLEDQYFPWRVTMPGEPV 250
Score = 77.0 bits (188), Expect = 4e-14
Identities = 64/224 (28%), Positives = 97/224 (43%), Gaps = 15/224 (6%)
Query: 34 ALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEG-LCGKKIKSLSYGSGPHVLLSTE 92
+L++TD EV+ G G G T P KL G L G + ++ G L +
Sbjct: 45 SLFLTDKGEVYSCGWGADGQTGLGHYNITSSPTKLGGDLAGVNVIQVA-TYGDCCLAVSA 103
Query: 93 DGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAW 152
DG ++ WG++ Y QL + T + + + + +V + ACG L +G VF W
Sbjct: 104 DGGLFGWGNSEYLQLASVTDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVW 163
Query: 153 GYNNCGQVGSGSTANQ--------PTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYG 204
GY G +G G + PT +T +V I CG + A+ + GE++
Sbjct: 164 GY---GILGKGPNLVESAVPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFV 220
Query: 205 WGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLAL 248
WG N G LG+G +Q P RV + CG H + L
Sbjct: 221 WGKNIRGCLGIGRLEDQYFPWRVTMPGEPV--DVACGVDHMVTL 262
Score = 73.2 bits (178), Expect = 6e-13
Identities = 64/225 (28%), Positives = 95/225 (42%), Gaps = 15/225 (6%)
Query: 100 GHNGYSQLGNGTTNQGIAPVQVCTNLLIK---QVVEVACGSHHSMALAADGEVFAWGYNN 156
G+N Y Q G I + + QVV+VACG HS+ L GEV++ G+
Sbjct: 2 GNNSYGQCGRKVVENEIYSESHRVHRMQDFDGQVVQVACGQDHSLFLTDKGEVYSCGWGA 61
Query: 157 CGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLG 216
GQ G G +P K+ L V+ +A +AV +G ++GWG + QL
Sbjct: 62 DGQTGLGHYNITSSPTKLGGDLAGVNVIQVATYGDCCLAVSADGGLFGWGNSEYLQLASV 121
Query: 217 NNGNQLTPVRVAALHSV-CVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG-NKNNLL 274
+ Q+ R V V Q CG L EG ++ WG YG LG G N
Sbjct: 122 TDSTQVNVPRCLHFSGVGKVRQAACGGTGCAVLNGEGHVFVWG---YGILGKGPNLVESA 178
Query: 275 SPAHI------MVEKERVVEIAACHSAHTS-AAKTQGGHVYMWGQ 312
P I + E ++++ + AA T G +++WG+
Sbjct: 179 VPEMIPPTLFGLTEFNPEIQVSRIRCGLSRFAALTNKGELFVWGK 223
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 85.5 bits (210), Expect = 1e-16
Identities = 50/161 (31%), Positives = 82/161 (50%), Gaps = 2/161 (1%)
Query: 89 LSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGE 148
LS + +V++WG + +LG G ++G Q L + V ++ CG+ +AL G
Sbjct: 18 LSGYESLVFSWGDGDFGKLGRG-GSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGV 76
Query: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208
V+ WG + ++G S + P +V L K++V +A G +AV+D+G+VY WG N
Sbjct: 77 VWTWGKGDYFRLGHRSDVHVRKP-QVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDN 135
Query: 209 GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALT 249
+GQ G G P V L + + CG +H++A T
Sbjct: 136 DHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 82.8 bits (203), Expect = 7e-16
Identities = 50/153 (32%), Positives = 85/153 (55%), Gaps = 3/153 (1%)
Query: 43 VFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN 102
VF +G LG G ++ +P+ +E L G+ + + G+ +L T+ GVV+ WG
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA-QFLLALTKSGVVWTWGKG 83
Query: 103 GYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGS 162
Y +LG+ ++ + QV L K++V VA G+ H +A+ G+V+AWG N+ GQ G+
Sbjct: 84 DYFRLGH-RSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 142
Query: 163 GSTANQPTPRKVTNCLHIKRVVGIACGQTSSMA 195
G+T P V L ++++ +ACG + S+A
Sbjct: 143 GTTTVNRKPTLVQG-LEGQKIMCVACGSSHSVA 174
Score = 73.6 bits (179), Expect = 4e-13
Identities = 45/154 (29%), Positives = 73/154 (47%), Gaps = 1/154 (0%)
Query: 149 VFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYN 208
VF+WG + G++G G + P+ + L+ + V I CG +A+ +G V+ WG
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFLLALTKSGVVWTWGKG 83
Query: 209 GNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTG 268
+LG ++ + P V L + + G H LA+ D G +YAWG N +GQ G G
Sbjct: 84 DYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNG 143
Query: 269 NKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKT 302
P + + + + AC S+H+ A T
Sbjct: 144 TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTT 177
Score = 64.3 bits (155), Expect = 3e-10
Identities = 46/130 (35%), Positives = 65/130 (50%), Gaps = 4/130 (3%)
Query: 15 PQEIASI--RKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72
PQ I + + C A L +T + V+ +G LG + P+ +EGL
Sbjct: 47 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGLR 106
Query: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE 132
GKKI ++ G+ H L + G VYAWG N + Q GNGTT P V L ++++
Sbjct: 107 GKKIVHVAVGA-QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLV-QGLEGQKIMC 164
Query: 133 VACGSHHSMA 142
VACGS HS+A
Sbjct: 165 VACGSSHSVA 174
Score = 55.5 bits (132), Expect = 1e-07
Identities = 34/111 (30%), Positives = 52/111 (46%), Gaps = 3/111 (2%)
Query: 202 VYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANT 261
V+ WG G+LG G + P + L+ V QI CG LALT G+++ WG
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
Query: 262 YGQLGTGNKNNLLSPAHIM-VEKERVVEIAACHSAHTSAAKTQGGHVYMWG 311
Y +LG + ++ P + + +++V +A A A G VY WG
Sbjct: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAV--GAQHCLAVMDSGQVYAWG 133
Score = 34.7 bits (78), Expect = 0.22
Identities = 24/81 (29%), Positives = 36/81 (44%), Gaps = 2/81 (2%)
Query: 15 PQEIASIR--KACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72
PQ + +R K A L V D+ +V+ +G N G G P ++GL
Sbjct: 99 PQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLE 158
Query: 73 GKKIKSLSYGSGPHVLLSTED 93
G+KI ++ GS V +T D
Sbjct: 159 GQKIMCVACGSSHSVAWTTVD 179
Score = 33.1 bits (74), Expect = 0.65
Identities = 20/65 (30%), Positives = 30/65 (46%), Gaps = 7/65 (10%)
Query: 251 EGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACH---SAHTSAAKTQGGHV 307
E L+++WG +G+LG G P +I ER+ C A A T+ G V
Sbjct: 22 ESLVFSWGDGDFGKLGRGGSEGCNIPQNI----ERLNGQGVCQIECGAQFLLALTKSGVV 77
Query: 308 YMWGQ 312
+ WG+
Sbjct: 78 WTWGK 82
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 84.0 bits (206), Expect = 3e-16
Identities = 50/153 (32%), Positives = 86/153 (56%), Gaps = 3/153 (1%)
Query: 43 VFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHN 102
VF +G LG G ++ +P+ +E L G+ + + G+ +L T+ GVV+ WG
Sbjct: 727 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGA-QFLLALTKSGVVWTWGKG 785
Query: 103 GYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGS 162
Y +LG+ ++ + +QV L K++V VA G+ H +A+ G+V+AWG N+ GQ G+
Sbjct: 786 DYFRLGH-RSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGN 844
Query: 163 GSTANQPTPRKVTNCLHIKRVVGIACGQTSSMA 195
G+T P V L ++++ +ACG + S+A
Sbjct: 845 GTTTVNRKPMLVQG-LEGQKIMCVACGSSHSVA 876
Score = 82.8 bits (203), Expect = 7e-16
Identities = 48/156 (30%), Positives = 80/156 (51%), Gaps = 2/156 (1%)
Query: 94 GVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWG 153
G+V++WG + +LG G + +G Q L + V ++ CG+ +AL G V+ WG
Sbjct: 725 GLVFSWGDGDFGKLGRGGS-EGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWG 783
Query: 154 YNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQL 213
+ ++G S + +V L K++V +A G +AV+D+G+VY WG N +GQ
Sbjct: 784 KGDYFRLGHRSDVHV-RKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQ 842
Query: 214 GLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALT 249
G G P+ V L + + CG +H++A T
Sbjct: 843 GNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 878
Score = 70.5 bits (171), Expect = 4e-12
Identities = 45/156 (28%), Positives = 73/156 (46%), Gaps = 1/156 (0%)
Query: 147 GEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVLDNGEVYGWG 206
G VF+WG + G++G G + P+ + L+ + V I CG +A+ +G V+ WG
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVCQIECGAQFLLALTKSGVVWTWG 783
Query: 207 YNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266
+LG ++ + V L + + G H LA+ D G +YAWG N +GQ G
Sbjct: 784 KGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQG 843
Query: 267 TGNKNNLLSPAHIMVEKERVVEIAACHSAHTSAAKT 302
G P + + + + AC S+H+ A T
Sbjct: 844 NGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWTT 879
Score = 60.8 bits (146), Expect = 3e-09
Identities = 45/130 (34%), Positives = 65/130 (50%), Gaps = 4/130 (3%)
Query: 15 PQEIASI--RKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLC 72
PQ I + + C A L +T + V+ +G LG + + +EGL
Sbjct: 749 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGLR 808
Query: 73 GKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVE 132
GKKI ++ G+ H L + G VYAWG N + Q GNGTT P+ V L ++++
Sbjct: 809 GKKIVHVAVGA-QHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLV-QGLEGQKIMC 866
Query: 133 VACGSHHSMA 142
VACGS HS+A
Sbjct: 867 VACGSSHSVA 876
Score = 53.1 bits (126), Expect = 6e-07
Identities = 37/119 (31%), Positives = 50/119 (42%), Gaps = 15/119 (12%)
Query: 200 GEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGA 259
G V+ WG G+LG G + P + L+ V QI CG LALT G+++ WG
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGK 784
Query: 260 NTYGQLGTGNKNNLLSPAHIMVEKERVVE-------IAACHSAHTSAAKTQGGHVYMWG 311
Y +LG + + V K +VVE + A A G VY WG
Sbjct: 785 GDYFRLG--------HRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWG 835
Score = 33.1 bits (74), Expect = 0.65
Identities = 21/72 (29%), Positives = 32/72 (44%)
Query: 22 RKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQSTLVPKKLEGLCGKKIKSLSY 81
+K A L V D+ +V+ +G N G G P ++GL G+KI ++
Sbjct: 810 KKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVAC 869
Query: 82 GSGPHVLLSTED 93
GS V +T D
Sbjct: 870 GSSHSVAWTTMD 881
>gi|209364523 alsin isoform 2 [Homo sapiens]
Length = 396
Score = 82.4 bits (202), Expect = 9e-16
Identities = 64/200 (32%), Positives = 97/200 (48%), Gaps = 27/200 (13%)
Query: 63 LVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVC 122
+ P++L G GK + + G H +L TEDG VY++G T PV++C
Sbjct: 30 ITPERLPGWGGKTVLQAALGV-KHGVLLTEDGEVYSFG----------TLPWRSGPVEIC 78
Query: 123 T------NLLIKQ-VVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
N L+ Q V+ VA GS HS A+ +G + WG N+ GQ + P P V+
Sbjct: 79 PSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
Query: 176 ------NCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVA 228
+ L R++ +ACG+ ++A+ + E++ WG QLGL +T P +V
Sbjct: 139 IADSEASPLLAVRILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVE 196
Query: 229 ALHSVCVNQIVCGYAHTLAL 248
L V Q+ CG H+LAL
Sbjct: 197 HLAGRVVLQVACGAFHSLAL 216
Score = 72.0 bits (175), Expect = 1e-12
Identities = 56/186 (30%), Positives = 86/186 (46%), Gaps = 25/186 (13%)
Query: 128 KQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIA 187
K V++ A G H + L DGEV+++G SG P+ + N L + V+ +A
Sbjct: 41 KTVLQAALGVKHGVLLTEDGEVYSFGTLPWR---SGPVEICPSSPILENALVGQYVITVA 97
Query: 188 CGQTSSMAVLDNGEVYGWGYNGNGQLGLGN-------NGNQLTPVRVAALHSVCVNQIVC 240
G S AV DNG Y WG N GQ + N N + + L +V + Q+ C
Sbjct: 98 TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
Query: 241 GYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIA-------ACH 293
G HTLAL+ ++AW GTG + L++ A + + ++V +A AC
Sbjct: 158 GEEHTLALSISREIWAW--------GTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACG 209
Query: 294 SAHTSA 299
+ H+ A
Sbjct: 210 AFHSLA 215
Score = 55.8 bits (133), Expect = 9e-08
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 13/135 (9%)
Query: 71 LCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAP----VQVCTN-- 124
L G+ + +++ GS H T++GV Y WG N Q NQ P V + +
Sbjct: 88 LVGQYVITVATGSF-HSGAVTDNGVAYMWGENSAGQCA--VANQQYVPEPNPVSIADSEA 144
Query: 125 --LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKR 182
LL +++++ACG H++AL+ E++AWG C Q+G +TA T + L +
Sbjct: 145 SPLLAVRILQLACGEEHTLALSISREIWAWG-TGC-QLGLITTAFPVTKPQKVEHLAGRV 202
Query: 183 VVGIACGQTSSMAVL 197
V+ +ACG S+A++
Sbjct: 203 VLQVACGAFHSLALV 217
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/141 (25%), Positives = 63/141 (44%), Gaps = 16/141 (11%)
Query: 181 KRVVGIACGQTSSMAVLDNGEVYGWGYNG--NGQLGLGNNGNQLTPVRVAALHSVCVNQI 238
K V+ A G + + ++GEVY +G +G + + + +P+ AL V +
Sbjct: 41 KTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS----SPILENALVGQYVITV 96
Query: 239 VCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKE--------RVVEIA 290
G H+ A+TD G+ Y WG N+ GQ N+ + P + + R++++
Sbjct: 97 ATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQL- 155
Query: 291 ACHSAHTSAAKTQGGHVYMWG 311
AC HT A ++ WG
Sbjct: 156 ACGEEHTLALSI-SREIWAWG 175
Score = 36.6 bits (83), Expect = 0.059
Identities = 38/150 (25%), Positives = 65/150 (43%), Gaps = 17/150 (11%)
Query: 222 LTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV 281
+TP R+ V Q G H + LT++G +Y ++G L + + P+ ++
Sbjct: 30 ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVY-----SFGTLPWRSGPVEICPSSPIL 84
Query: 282 EKERVVE--IAACHSAHTSAAKTQGGHVYMWGQ-CRGQSVI-----LPHLTHFSCTDDVF 333
E V + I + S A T G YMWG+ GQ + +P S D
Sbjct: 85 ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSE- 143
Query: 334 ACFATPAVSWRLLSVEHEDFLTVAESLKKE 363
A+P ++ R+L + + T+A S+ +E
Sbjct: 144 ---ASPLLAVRILQLACGEEHTLALSISRE 170
>gi|40316935 alsin isoform 1 [Homo sapiens]
Length = 1657
Score = 82.4 bits (202), Expect = 9e-16
Identities = 64/200 (32%), Positives = 97/200 (48%), Gaps = 27/200 (13%)
Query: 63 LVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVC 122
+ P++L G GK + + G H +L TEDG VY++G T PV++C
Sbjct: 30 ITPERLPGWGGKTVLQAALGV-KHGVLLTEDGEVYSFG----------TLPWRSGPVEIC 78
Query: 123 T------NLLIKQ-VVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
N L+ Q V+ VA GS HS A+ +G + WG N+ GQ + P P V+
Sbjct: 79 PSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
Query: 176 ------NCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVA 228
+ L R++ +ACG+ ++A+ + E++ WG QLGL +T P +V
Sbjct: 139 IADSEASPLLAVRILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVE 196
Query: 229 ALHSVCVNQIVCGYAHTLAL 248
L V Q+ CG H+LAL
Sbjct: 197 HLAGRVVLQVACGAFHSLAL 216
Score = 72.0 bits (175), Expect = 1e-12
Identities = 56/186 (30%), Positives = 86/186 (46%), Gaps = 25/186 (13%)
Query: 128 KQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIA 187
K V++ A G H + L DGEV+++G SG P+ + N L + V+ +A
Sbjct: 41 KTVLQAALGVKHGVLLTEDGEVYSFGTLPWR---SGPVEICPSSPILENALVGQYVITVA 97
Query: 188 CGQTSSMAVLDNGEVYGWGYNGNGQLGLGN-------NGNQLTPVRVAALHSVCVNQIVC 240
G S AV DNG Y WG N GQ + N N + + L +V + Q+ C
Sbjct: 98 TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
Query: 241 GYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIA-------ACH 293
G HTLAL+ ++AW GTG + L++ A + + ++V +A AC
Sbjct: 158 GEEHTLALSISREIWAW--------GTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACG 209
Query: 294 SAHTSA 299
+ H+ A
Sbjct: 210 AFHSLA 215
Score = 62.0 bits (149), Expect = 1e-09
Identities = 50/183 (27%), Positives = 84/183 (45%), Gaps = 13/183 (7%)
Query: 80 SYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLI-KQVVEVACGSH 138
+Y LL + V+ WG QLG+G + P+ C L K+V+ + G +
Sbjct: 512 TYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPL--CVKCLDGKEVIHLEAGGY 569
Query: 139 HSMALAADGEVFAWGYNNCGQVG-SGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVL 197
HS+AL A +V++WG N GQ+G S P K+++ V IA G+ S+ ++
Sbjct: 570 HSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISS---ENGVWSIAAGRDYSLFLV 626
Query: 198 DNGEVY-GWGYNGNGQLGLG-----NNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
D + G Y+G G N+ TPV ++ ++++ G LAL D+
Sbjct: 627 DTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDK 686
Query: 252 GLL 254
++
Sbjct: 687 NIM 689
Score = 57.4 bits (137), Expect = 3e-08
Identities = 36/104 (34%), Positives = 55/104 (52%), Gaps = 4/104 (3%)
Query: 167 NQPTPRKVTNCLHIK-RVVGIA---CGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQL 222
+Q +PR + +K R V + G+ ++ EV+ WG GQLG G+ +L
Sbjct: 489 SQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRL 548
Query: 223 TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266
P+ V L V + G H+LALT + +Y+WG+NT+GQLG
Sbjct: 549 QPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLG 592
Score = 55.8 bits (133), Expect = 9e-08
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 13/135 (9%)
Query: 71 LCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAP----VQVCTN-- 124
L G+ + +++ GS H T++GV Y WG N Q NQ P V + +
Sbjct: 88 LVGQYVITVATGSF-HSGAVTDNGVAYMWGENSAGQCA--VANQQYVPEPNPVSIADSEA 144
Query: 125 --LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKR 182
LL +++++ACG H++AL+ E++AWG C Q+G +TA T + L +
Sbjct: 145 SPLLAVRILQLACGEEHTLALSISREIWAWG-TGC-QLGLITTAFPVTKPQKVEHLAGRV 202
Query: 183 VVGIACGQTSSMAVL 197
V+ +ACG S+A++
Sbjct: 203 VLQVACGAFHSLALV 217
Score = 45.4 bits (106), Expect = 1e-04
Identities = 36/141 (25%), Positives = 63/141 (44%), Gaps = 16/141 (11%)
Query: 181 KRVVGIACGQTSSMAVLDNGEVYGWGYNG--NGQLGLGNNGNQLTPVRVAALHSVCVNQI 238
K V+ A G + + ++GEVY +G +G + + + +P+ AL V +
Sbjct: 41 KTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS----SPILENALVGQYVITV 96
Query: 239 VCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKE--------RVVEIA 290
G H+ A+TD G+ Y WG N+ GQ N+ + P + + R++++
Sbjct: 97 ATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQL- 155
Query: 291 ACHSAHTSAAKTQGGHVYMWG 311
AC HT A ++ WG
Sbjct: 156 ACGEEHTLALSI-SREIWAWG 175
Score = 36.6 bits (83), Expect = 0.059
Identities = 38/150 (25%), Positives = 65/150 (43%), Gaps = 17/150 (11%)
Query: 222 LTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV 281
+TP R+ V Q G H + LT++G +Y ++G L + + P+ ++
Sbjct: 30 ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVY-----SFGTLPWRSGPVEICPSSPIL 84
Query: 282 EKERVVE--IAACHSAHTSAAKTQGGHVYMWGQ-CRGQSVI-----LPHLTHFSCTDDVF 333
E V + I + S A T G YMWG+ GQ + +P S D
Sbjct: 85 ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSE- 143
Query: 334 ACFATPAVSWRLLSVEHEDFLTVAESLKKE 363
A+P ++ R+L + + T+A S+ +E
Sbjct: 144 ---ASPLLAVRILQLACGEEHTLALSISRE 170
Score = 33.1 bits (74), Expect = 0.65
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 21/177 (11%)
Query: 190 QTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTP--VRVAA---LHSVCVNQIVCGYAH 244
++SS+ + E G G+ +L L +Q++P +R AA +V + G A
Sbjct: 463 KSSSLVDIREEETEG----GSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEAD 518
Query: 245 TLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI-MVEKERVVEIAACHSAHTSAAKTQ 303
L + ++ WG GQLG G+ L P + ++ + V+ + A + S A T
Sbjct: 519 ALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEA--GGYHSLALTA 576
Query: 304 GGHVYMWG-QCRGQ------SVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDF 353
VY WG GQ +P L S + V++ A + L V+ EDF
Sbjct: 577 KSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSENGVWSIAA--GRDYSLFLVDTEDF 631
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,481,924
Number of Sequences: 37866
Number of extensions: 892978
Number of successful extensions: 2539
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 1642
Number of HSP's gapped (non-prelim): 359
length of query: 531
length of database: 18,247,518
effective HSP length: 107
effective length of query: 424
effective length of database: 14,195,856
effective search space: 6019042944
effective search space used: 6019042944
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.