BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|134244587 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 [Homo sapiens] (353 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|134244587 endothelial differentiation, sphingolipid G-protein... 702 0.0 gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] 331 7e-91 gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] 297 8e-81 gi|13540517 endothelial differentiation, sphingolipid G-protein-... 280 2e-75 gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sa... 205 4e-53 gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] 198 7e-51 gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] 198 7e-51 gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] 189 4e-48 gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] 186 2e-47 gi|170671732 melanocortin 3 receptor [Homo sapiens] 127 1e-29 gi|4885325 G protein-coupled receptor 3 [Homo sapiens] 127 2e-29 gi|4885341 G protein-coupled receptor 6 [Homo sapiens] 126 3e-29 gi|4885295 G protein-coupled receptor 12 [Homo sapiens] 124 1e-28 gi|119508433 melanocortin 4 receptor [Homo sapiens] 111 1e-24 gi|5174535 melanocortin 5 receptor [Homo sapiens] 106 3e-23 gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens] 104 1e-22 gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22 gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22 gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22 gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22 gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] 103 2e-22 gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] 103 2e-22 gi|193083134 melanocortin 1 receptor [Homo sapiens] 99 7e-21 gi|5921992 adenosine A2a receptor [Homo sapiens] 97 2e-20 gi|4505127 melanocortin 2 receptor [Homo sapiens] 92 7e-19 gi|4501951 adenosine A2b receptor [Homo sapiens] 82 7e-16 gi|5174593 melatonin receptor 1A [Homo sapiens] 81 1e-15 gi|5174595 melatonin receptor 1B [Homo sapiens] 80 2e-15 gi|115305569 adenosine A1 receptor [Homo sapiens] 78 1e-14 gi|4501947 adenosine A1 receptor [Homo sapiens] 78 1e-14 >gi|134244587 endothelial differentiation, sphingolipid G-protein-coupled receptor, 5 [Homo sapiens] Length = 353 Score = 702 bits (1811), Expect = 0.0 Identities = 353/353 (100%), Positives = 353/353 (100%) Query: 1 MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR 60 MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR Sbjct: 1 MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVAR 60 Query: 61 NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV 120 NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV Sbjct: 61 NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASV 120 Query: 121 FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS 180 FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS Sbjct: 121 FSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACS 180 Query: 181 TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG 240 TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG Sbjct: 181 TVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLG 240 Query: 241 VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL 300 VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL Sbjct: 241 VFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVL 300 Query: 301 RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV 353 RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV Sbjct: 301 RPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV 353 >gi|13027636 sphingosine-1-phosphate receptor 1 [Homo sapiens] Length = 382 Score = 331 bits (848), Expect = 7e-91 Identities = 161/315 (51%), Positives = 220/315 (69%), Gaps = 12/315 (3%) Query: 3 SLYSEYLNPNKVQEHYNYT-KETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARN 61 S S+Y+N + + HYNYT K + + S ++ S +++CC I++EN+ VL+ + + Sbjct: 14 SSVSDYVNYDIIVRHYNYTGKLNISADKENSIKLTSVVFILICCFIILENIFVLLTIWKT 73 Query: 62 SKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVF 121 KFH MY F+GNLA SDLLAGVA+ AN LLSG+ T +LTP QWF REGS F+ LSASVF Sbjct: 74 KKFHRPMYYFIGNLALSDLLAGVAYTANLLLSGATTYKLTPAQWFLREGSMFVALSASVF 133 Query: 122 SLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACST 181 SLLAIAIER++ + K+KL+ + R+ LLI A W+ISL+LGGLPI+GWNC+ L +CST Sbjct: 134 SLLAIAIERYITMLKMKLHNGSNNFRLFLLISACWVISLILGGLPIMGWNCISALSSCST 193 Query: 182 VLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRS-----------SHADMAAPQTLA 230 VLPLY KHY+L T+F+++LL+IV LY RIY +VR+ S A ++ ++LA Sbjct: 194 VLPLYHKHYILFCTTVFTLLLLSIVILYCRIYSLVRTRSRRLTFRKNISKASRSSEKSLA 253 Query: 231 LLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTW 290 LLKTV IVL VFI CW P F +LLLD C V +C IL++A YF ++ LNS NP+IYT Sbjct: 254 LLKTVIIVLSVFIACWAPLFILLLLDVGCKVKTCDILFRAEYFLVLAVLNSGTNPIIYTL 313 Query: 291 RSRDLRREVLRPLQC 305 ++++RR +R + C Sbjct: 314 TNKEMRRAFIRIMSC 328 >gi|38788193 sphingosine-1-phosphate receptor 3 [Homo sapiens] Length = 378 Score = 297 bits (761), Expect = 8e-81 Identities = 160/336 (47%), Positives = 219/336 (65%), Gaps = 12/336 (3%) Query: 14 VQEHYNYTKETLETQETTSR--QVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLF 71 ++EHY Y + + S + + +++C IV+ENL+VLIA+ +N+KFH+ MY F Sbjct: 18 LREHYQYVGKLAGRLKEASEGSTLTTVLFLVICSFIVLENLMVLIAIWKNNKFHNRMYFF 77 Query: 72 LGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERH 131 +GNLA DLLAG+A+ N L+SG T L+P WF REGS F+ L AS SLLAIAIERH Sbjct: 78 IGNLALCDLLAGIAYKVNILMSGKKTFSLSPTVWFLREGSMFVALGASTCSLLAIAIERH 137 Query: 132 VAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYV 191 + + K++ Y ++K R+ LLIG WLI+ LG LPILGWNCL +L CST+LPLY+K Y+ Sbjct: 138 LTMIKMRPYDANKRHRVFLLIGMCWLIAFTLGALPILGWNCLHNLPDCSTILPLYSKKYI 197 Query: 192 LCVVTIFSIILLAIVALYVRIYCVVRSSHADMA----APQTLALLKTVTIVLGVFIVCWL 247 ++IF+ IL+ IV LY RIY +V+SS +A + +++ALL+TV IV+ VFI CW Sbjct: 198 AFCISIFTAILVTIVILYARIYFLVKSSSRKVANHNNSERSMALLRTVVIVVSVFIACWS 257 Query: 248 PAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWR 307 P F + L+D AC V +CPIL+KA +F ++ LNS +NPVIYT S+++RR R L C Sbjct: 258 PLFILFLIDVACRVQACPILFKAQWFIVLAVLNSAMNPVIYTLASKEMRRAFFR-LVC-- 314 Query: 308 PGVGVQGRRRGGTPGHHLL-PLRS-SSSLERGMHMP 341 V+GR +P L P RS SSS H P Sbjct: 315 -NCLVRGRGARASPIQPALDPSRSKSSSSNNSSHSP 349 >gi|13540517 endothelial differentiation, sphingolipid G-protein-coupled receptor, 8 [Homo sapiens] Length = 398 Score = 280 bits (715), Expect = 2e-75 Identities = 156/327 (47%), Positives = 204/327 (62%), Gaps = 21/327 (6%) Query: 6 SEYLNPNKVQE----HYNYTKETLETQETTSRQVASAFIVIL--CCAIVVENLLVLIAVA 59 S L P V E HYNYT + + + + +V L C IV+ENL VL+ + Sbjct: 3 SGLLRPAPVSEVIVLHYNYTGKLRGARYQPGAGLRADAVVCLAVCAFIVLENLAVLLVLG 62 Query: 60 RNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSAS 119 R+ +FH+ M+L LG+L SDLLAG A+ AN LLSG +TL+L+P WFAREG F+ L+AS Sbjct: 63 RHPRFHAPMFLLLGSLTLSDLLAGAAYAANILLSGPLTLKLSPALWFAREGGVFVALTAS 122 Query: 120 VFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEAC 179 V SLLAIA+ER + +A+ R L + A+W +SL+LG LP LGWNCLG L+AC Sbjct: 123 VLSLLAIALERSLTMARRGPAPVSSRGRTLAMAAAAWGVSLLLGLLPALGWNCLGRLDAC 182 Query: 180 STVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAA-------------- 225 STVLPLYAK YVL V F IL AI ALY RIYC VR++ + A Sbjct: 183 STVLPLYAKAYVLFCVLAFVGILAAICALYARIYCQVRANARRLPARPGTAGTTSTRARR 242 Query: 226 -PQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLN 284 P++LALL+T+++VL F+ CW P F +LLLD ACP +CP+L +A F ++ NSLLN Sbjct: 243 KPRSLALLRTLSVVLLAFVACWGPLFLLLLLDVACPARTCPVLLQADPFLGLAMANSLLN 302 Query: 285 PVIYTWRSRDLRREVLRPLQCWRPGVG 311 P+IYT +RDLR +LR + C R G Sbjct: 303 PIIYTLTNRDLRHALLRLVCCGRHSCG 329 >gi|4503459 sphingosine-1-phosphate receptor 4 precursor [Homo sapiens] Length = 384 Score = 205 bits (522), Expect = 4e-53 Identities = 117/280 (41%), Positives = 170/280 (60%), Gaps = 6/280 (2%) Query: 41 VILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRL 100 V C +V+ENLLVL A+ + + +Y L N+ SDLL G A++AN LLSG+ T RL Sbjct: 54 VAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRL 113 Query: 101 TPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAK-VKLYGSDKSCRMLLLIGASWLIS 159 P QWF REG F L+AS FSLL A ER + + V G+ K+ R+ IG WL++ Sbjct: 114 APAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLA 173 Query: 160 LVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSS 219 +LG LP+LGWNCL + CS++LPLY+K Y+L + IF+ +L I+ LY I+ +V++S Sbjct: 174 ALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQAS 233 Query: 220 HADMAAP----QTLALLKTVTIVLGVFIVCWLPAFSILLLD-YACPVHSCPILYKAHYFF 274 P + LLKTV ++L F+VCW P F +LL D + + + L + Sbjct: 234 GQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWIL 293 Query: 275 AVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQG 314 A++ LNS +NP+IY++RSR++ R VL L C +G++G Sbjct: 294 ALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRG 333 >gi|16950638 lysophosphatidic acid receptor 1 [Homo sapiens] Length = 364 Score = 198 bits (503), Expect = 7e-51 Identities = 107/321 (33%), Positives = 179/321 (55%), Gaps = 14/321 (4%) Query: 18 YNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAA 77 YN + + L T+ T ++ + +C I++ NLLV++A+ N +FH +Y + NLAA Sbjct: 34 YNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAA 93 Query: 78 SDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKV 137 +D AG+A+ +G T RLT W R+G +L+ASV +LLAIAIERH+ + ++ Sbjct: 94 ADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRM 153 Query: 138 KLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTI 197 +L+ + R++++I W +++V+G +P +GWNC+ +E CS + PLY+ Y++ Sbjct: 154 QLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIF 213 Query: 198 FSIILLAIVALYVRIYCVVRSSHADMAAPQT---------LALLKTVTIVLGVFIVCWLP 248 + + +V LY I+ VR M+ + ++LLKTV IVLG FI+CW P Sbjct: 214 NLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP 273 Query: 249 AFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWR- 307 +LLLD CP C +L +F ++ NS +NP+IY++R +++ + L C R Sbjct: 274 GLVLLLLDVCCP--QCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRS 331 Query: 308 --PGVGVQGRRRGGTPGHHLL 326 P +G R + +H + Sbjct: 332 ENPTGPTEGSDRSASSLNHTI 352 >gi|16950636 lysophosphatidic acid receptor 1 [Homo sapiens] Length = 364 Score = 198 bits (503), Expect = 7e-51 Identities = 107/321 (33%), Positives = 179/321 (55%), Gaps = 14/321 (4%) Query: 18 YNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAA 77 YN + + L T+ T ++ + +C I++ NLLV++A+ N +FH +Y + NLAA Sbjct: 34 YNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMANLAA 93 Query: 78 SDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKV 137 +D AG+A+ +G T RLT W R+G +L+ASV +LLAIAIERH+ + ++ Sbjct: 94 ADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRM 153 Query: 138 KLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTI 197 +L+ + R++++I W +++V+G +P +GWNC+ +E CS + PLY+ Y++ Sbjct: 154 QLHTRMSNRRVVVVIVVIWTMAIVMGAIPSVGWNCICDIENCSNMAPLYSDSYLVFWAIF 213 Query: 198 FSIILLAIVALYVRIYCVVRSSHADMAAPQT---------LALLKTVTIVLGVFIVCWLP 248 + + +V LY I+ VR M+ + ++LLKTV IVLG FI+CW P Sbjct: 214 NLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLGAFIICWTP 273 Query: 249 AFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWR- 307 +LLLD CP C +L +F ++ NS +NP+IY++R +++ + L C R Sbjct: 274 GLVLLLLDVCCP--QCDVLAYEKFFLLLAEFNSAMNPIIYSYRDKEMSATFRQILCCQRS 331 Query: 308 --PGVGVQGRRRGGTPGHHLL 326 P +G R + +H + Sbjct: 332 ENPTGPTEGSDRSASSLNHTI 352 >gi|7305013 lysophosphatidic acid receptor 2 [Homo sapiens] Length = 351 Score = 189 bits (479), Expect = 4e-48 Identities = 117/325 (36%), Positives = 174/325 (53%), Gaps = 16/325 (4%) Query: 18 YNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAA 77 YN + + L + V A + + +++ NLLV+ A+A N +FH +Y LGNLAA Sbjct: 17 YNNSGKELSSHWRPKDVVVVALGLTVSVLVLLTNLLVIAAIASNRRFHQPIYYLLGNLAA 76 Query: 78 SDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKV 137 +DL AGVA++ +G T RL+ WF R+G +L+ASV +LLAIA+ERH ++ V Sbjct: 77 ADLFAGVAYLFLMFHTGPRTARLSLEGWFLRQGLLDTSLTASVATLLAIAVERHRSVMAV 136 Query: 138 KLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTI 197 +L+ R+++LI W+ +L LG LP W+CL L+ CS + PL ++ Y+ Sbjct: 137 QLHSRLPRGRVVMLIVGVWVAALGLGLLPAHSWHCLCALDRCSRMAPLLSRSYLAVWALS 196 Query: 198 FSIILLAIVALYVRIYCVVRSSHADMA---------APQTLALLKTVTIVLGVFIVCWLP 248 ++ L +VA+Y RI+ VR MA TL+L+KTV I+LG F+VCW P Sbjct: 197 SLLVFLLMVAVYTRIFFYVRRRVQRMAEHVSCHPRYRETTLSLVKTVVIILGAFVVCWTP 256 Query: 249 AFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQC--- 305 +LLLD SC +L YF ++ NSL+N +Y+ R ++RR R L C Sbjct: 257 GQVVLLLD-GLGCESCNVLAVEKYFLLLAEANSLVNAAVYSCRDAEMRRTFRRLLCCACL 315 Query: 306 ---WRPGVGVQGRRRGGTPGHHLLP 327 R V +GG +LP Sbjct: 316 RQSTRESVHYTSSAQGGASTRIMLP 340 >gi|6912348 lysophosphatidic acid receptor 3 [Homo sapiens] Length = 353 Score = 186 bits (473), Expect = 2e-47 Identities = 99/294 (33%), Positives = 168/294 (57%), Gaps = 18/294 (6%) Query: 29 ETTSRQVASAFIVILCCA------IVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLA 82 +T + +++LC I N LV+ AV +N KFH Y L NLAA+D A Sbjct: 20 DTVDDWTGTKLVIVLCVGTFFCLFIFFSNSLVIAAVIKNRKFHFPFYYLLANLAAADFFA 79 Query: 83 GVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGS 142 G+A+V +G V+ LT +WF R+G +L+AS+ +LL IA+ERH++I +++++ + Sbjct: 80 GIAYVFLMFNTGPVSKTLTVNRWFLRQGLLDSSLTASLTNLLVIAVERHMSIMRMRVHSN 139 Query: 143 DKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIIL 202 R+ LLI W I++ +G +P LGWNCL ++ ACS++ P+Y++ Y++ + Sbjct: 140 LTKKRVTLLILLVWAIAIFMGAVPTLGWNCLCNISACSSLAPIYSRSYLVFWTVSNLMAF 199 Query: 203 LAIVALYVRIYCVVRSSHADMAAPQT----------LALLKTVTIVLGVFIVCWLPAFSI 252 L +V +Y+RIY V+ ++ +P T + L+KTV VLG F+VCW P + Sbjct: 200 LIMVVVYLRIYVYVKRK-TNVLSPHTSGSISRRRTPMKLMKTVMTVLGAFVVCWTPGLVV 258 Query: 253 LLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCW 306 LLLD C + + +F ++ LNS++NP+IY+++ D+ + + + C+ Sbjct: 259 LLLD-GLNCRQCGVQHVKRWFLLLALLNSVVNPIIYSYKDEDMYGTMKKMICCF 311 >gi|170671732 melanocortin 3 receptor [Homo sapiens] Length = 323 Score = 127 bits (320), Expect = 1e-29 Identities = 103/304 (33%), Positives = 153/304 (50%), Gaps = 51/304 (16%) Query: 32 SRQVASAFI--------VILCCAIV--VENLLVLIAVARNSKFHSAMYLFLGNLAASDLL 81 S Q +SAF V L IV +EN+LV++AV RN HS MY FL +LA +D+L Sbjct: 27 SNQSSSAFCEQVFIKPEVFLSLGIVSLLENILVILAVVRNGNLHSPMYFFLCSLAVADML 86 Query: 82 AGVAFVANTLLSGSV-TLRLTPVQWFAR------EGSAFITLSASVFSLLAIAIERHVAI 134 V+ T++ V + LT F + + I+L AS+ +LLAIA++R+V I Sbjct: 87 VSVSNALETIMIAIVHSDYLTFEDQFIQHMDNIFDSMICISLVASICNLLAIAVDRYVTI 146 Query: 135 AKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLY--AKHYVL 192 Y S + R L L + W C G C V +Y +K ++ Sbjct: 147 FYALRYHSIMTVRKALT-------------LIVAIWVCCG---VCGVVFIVYSESKMVIV 190 Query: 193 CVVTIFSIILLAIVALYVRIYCVVR--------SSHADMAAPQTLALLK---TVTIVLGV 241 C++T+F ++L + LYV ++ R AD APQ + +K T+TI+LGV Sbjct: 191 CLITMFFAMMLLMGTLYVHMFLFARLHVKRIAALPPADGVAPQQHSCMKGAVTITILLGV 250 Query: 242 FIVCWLPAFSILLLDYACPVHSCPILYKAHY--FFAVSTLNSLLNPVIYTWRSRDLR--- 296 FI CW P F L+L CP + I Y AH+ + + NS+++P+IY +RS +LR Sbjct: 251 FIFCWAPFFLHLVLIITCPTNPYCICYTAHFNTYLVLIMCNSVIDPLIYAFRSLELRNTF 310 Query: 297 REVL 300 RE+L Sbjct: 311 REIL 314 >gi|4885325 G protein-coupled receptor 3 [Homo sapiens] Length = 330 Score = 127 bits (318), Expect = 2e-29 Identities = 91/280 (32%), Positives = 140/280 (50%), Gaps = 35/280 (12%) Query: 38 AFIVILCCA---IVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFV---ANTL 91 A+ V+LC + + EN LV+ + F + M+L +G+LA +DLLAG+ V A Sbjct: 42 AWDVVLCISGTLVSCENALVVAIIVGTPAFRAPMFLLVGSLAVADLLAGLGLVLHFAAVF 101 Query: 92 LSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSC-RMLL 150 GS + L V G + +AS+ SLLAI ++R++++ Y S+ + R + Sbjct: 102 CIGSAEMSLVLV------GVLAMAFTASIGSLLAITVDRYLSLYNALTYYSETTVTRTYV 155 Query: 151 LIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSI--ILLAIVAL 208 ++ W +L LG LP+L WNCL L C V PL H V+ + F + I+L + A Sbjct: 156 MLALVWGGALGLGLLPVLAWNCLDGLTTCGVVYPLSKNHLVVLAIAFFMVFGIMLQLYAQ 215 Query: 209 YVRIYCVVRSSHADMAAPQTLAL-----------LKTVTIVLGVFIVCWLPAFSILLLDY 257 RI C HA A Q L + T+ +VLG F CWLP LL Sbjct: 216 ICRIVC----RHAQQIALQRHLLPASHYVATRKGIATLAVVLGAFAACWLPFTVYCLLGD 271 Query: 258 ACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRR 297 A HS P+ + +T NS++NP+IY +R++D+++ Sbjct: 272 A---HSPPLY--TYLTLLPATYNSMINPIIYAFRNQDVQK 306 >gi|4885341 G protein-coupled receptor 6 [Homo sapiens] Length = 362 Score = 126 bits (317), Expect = 3e-29 Identities = 97/277 (35%), Positives = 146/277 (52%), Gaps = 35/277 (12%) Query: 41 VILCCA---IVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTL---LSG 94 V+LC + I EN LV+ +A + M++ +G+LA +DLLAG + + + L Sbjct: 77 VLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLLAGCGLILHFVFQYLVP 136 Query: 95 SVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRML-LLIG 153 S T+ L V G + +ASV SLLAI ++R++++ Y S ++ + LL+ Sbjct: 137 SETVSLLTV------GFLVASFAASVSSLLAITVDRYLSLYNALTYYSRRTLLGVHLLLA 190 Query: 154 ASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIY 213 A+W +SL LG LP+LGWNCL ACS V PL H L F + + ++ LYVRI Sbjct: 191 ATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI-MLHLYVRI- 248 Query: 214 CVVRSSHAD--------MAAPQTLALLK---TVTIVLGVFIVCWLPAFSILLLDYACPV- 261 C V HA +A P A K T+ +VLG F WLP F+I C V Sbjct: 249 CQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLP-FAIY-----CVVG 302 Query: 262 -HSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRR 297 H P +Y + +T NS++NP+IY +R+++++R Sbjct: 303 SHEDPAVY-TYATLLPATYNSMINPIIYAFRNQEIQR 338 >gi|4885295 G protein-coupled receptor 12 [Homo sapiens] Length = 334 Score = 124 bits (311), Expect = 1e-28 Identities = 87/314 (27%), Positives = 154/314 (49%), Gaps = 29/314 (9%) Query: 1 MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCA---IVVENLLVLIA 57 + L +YL+ + + E V + + ++LC + I EN +V++ Sbjct: 9 LSGLPRDYLDAAAAENISAAVSSRVPAVEPEPELVVNPWDIVLCTSGTLISCENAIVVLI 68 Query: 58 VARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLS 117 + N + M+L +G+LA +DLLAG+ + N + + + T + G + S Sbjct: 69 IFHNPSLRAPMFLLIGSLALADLLAGIGLITNFVFAYLLQSEATKLVTI---GLIVASFS 125 Query: 118 ASVFSLLAIAIERHVAIAKVKLYGSDKSCRML-LLIGASWLISLVLGGLPILGWNCLGHL 176 ASV SLLAI ++R++++ Y S+++ +++ W S+ LG LP++GWNCL Sbjct: 126 ASVCSLLAITVDRYLSLYYALTYHSERTVTFTYVMLVMLWGTSICLGLLPVMGWNCLRDE 185 Query: 177 EACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQ--------- 227 CS V PL + + V+ F + ++ LY++I C + HA A Q Sbjct: 186 STCSVVRPLTKNNAAILSVS-FLFMFALMLQLYIQI-CKIVMRHAHQIALQHHFLATSHY 243 Query: 228 --TLALLKTVTIVLGVFIVCWLP-AFSILLLDYACP-VHSCPILYKAHYFFAVSTLNSLL 283 T + T+ I+LG F CW+P L+ DY P +++ L A Y NS++ Sbjct: 244 VTTRKGVSTLAIILGTFAACWMPFTLYSLIADYTYPSIYTYATLLPATY-------NSII 296 Query: 284 NPVIYTWRSRDLRR 297 NPVIY +R++++++ Sbjct: 297 NPVIYAFRNQEIQK 310 >gi|119508433 melanocortin 4 receptor [Homo sapiens] Length = 332 Score = 111 bits (277), Expect = 1e-24 Identities = 81/293 (27%), Positives = 148/293 (50%), Gaps = 33/293 (11%) Query: 35 VASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSG 94 V+ V L ++EN+LV++A+A+N HS MY F+ +LA +D+L V+ + T++ Sbjct: 46 VSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVIT 105 Query: 95 SVTLRLTPVQWFAREGSAFI------TLSASVFSLLAIAIERHVAIAKVKLYGSDKSC-R 147 + T Q F I +L AS+ SLL+IA++R+ I Y + + R Sbjct: 106 LLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKR 165 Query: 148 MLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVA 207 + ++I W V G L I+ + + ++C++T+F +L + + Sbjct: 166 VGIIISCIWAACTVSGILFIIYSD---------------SSAVIICLITMFFTMLALMAS 210 Query: 208 LYVRIYCVVRSSHADMAA-PQTLALLK--------TVTIVLGVFIVCWLPAFSILLLDYA 258 LYV ++ + R +A P T A+ + T+TI++GVF+VCW P F L+ + Sbjct: 211 LYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYIS 270 Query: 259 CPVHSCPILYKAHY--FFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPG 309 CP + + + +H+ + + NS+++P+IY RS++LR+ + C+ G Sbjct: 271 CPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLG 323 >gi|5174535 melanocortin 5 receptor [Homo sapiens] Length = 325 Score = 106 bits (265), Expect = 3e-23 Identities = 84/326 (25%), Positives = 156/326 (47%), Gaps = 40/326 (12%) Query: 3 SLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIV--VENLLVLIAVAR 60 S + +L+ N N + ++ + + + A V L ++ +EN+LV+ A+ + Sbjct: 4 SFHLHFLDLNLNATEGNLSGPNVKNKSSPCEDMGIAVEVFLTLGVISLLENILVIGAIVK 63 Query: 61 NSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLR-LTPVQWFAR------EGSAF 113 N HS MY F+ +LA +D+L ++ T+ + + L F R + Sbjct: 64 NKNLHSPMYFFVCSLAVADMLVSMSSAWETITIYLLNNKHLVIADAFVRHIDNVFDSMIC 123 Query: 114 ITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRML-LLIGASWLISLVLGGLPILGWNC 172 I++ AS+ SLLAIA++R+V I Y + R +I W C Sbjct: 124 ISVVASMCSLLAIAVDRYVTIFYALRYHHIMTARRSGAIIAGIWAF-------------C 170 Query: 173 LGHLEACSTVLPLYAK--HYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLA 230 G C V LY++ + +LC++++F +L +V+LY+ ++ + R+ +AA + Sbjct: 171 TG----CGIVFILYSESTYVILCLISMFFAMLFLLVSLYIHMFLLARTHVKRIAALPGAS 226 Query: 231 LLK---------TVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHY--FFAVSTL 279 + TVT++LGVF VCW P F L L +CP + + +H+ + + Sbjct: 227 SARQRTSMQGAVTVTMLLGVFTVCWAPFFLHLTLMLSCPQNLYCSRFMSHFNMYLILIMC 286 Query: 280 NSLLNPVIYTWRSRDLRREVLRPLQC 305 NS+++P+IY +RS+++R+ + C Sbjct: 287 NSVMDPLIYAFRSQEMRKTFKEIICC 312 >gi|4502929 cannabinoid receptor 2 (macrophage) [Homo sapiens] Length = 360 Score = 104 bits (260), Expect = 1e-22 Identities = 84/317 (26%), Positives = 146/317 (46%), Gaps = 27/317 (8%) Query: 14 VQEHYNYTKETLETQETTSRQVASA----FIVILCCAI----VVENLLVLIAVARNSKFH 65 V E N +K+ L++ + S + +LC + +EN+ VL + + + Sbjct: 6 VTEIANGSKDGLDSNPMKDYMILSGPQKTAVAVLCTLLGLLSALENVAVLYLILSSHQLR 65 Query: 66 -SAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLL 124 YLF+G+LA +D LA V F + + + + + GS +T +ASV SLL Sbjct: 66 RKPSYLFIGSLAGADFLASVVFACSFVNFHVFHGVDSKAVFLLKIGSVTMTFTASVGSLL 125 Query: 125 AIAIERHVAIAKVKLYGSDKSC-RMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVL 183 AI+R++ + Y + + R L+ +G W++S ++ LP++GW C CS + Sbjct: 126 LTAIDRYLCLRYPPSYKALLTRGRALVTLGIMWVLSALVSYLPLMGWTCCP--RPCSELF 183 Query: 184 PLYAKHYVLCVVTIFSIILLAIVALYVRI------YCVVRSSHADMAAP------QTLAL 231 PL Y+L + + + I+ Y + + S H D P + L Sbjct: 184 PLIPNDYLLSWLLFIAFLFSGIIYTYGHVLWKAHQHVASLSGHQDRQVPGMARMRLDVRL 243 Query: 232 LKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTL-NSLLNPVIYTW 290 KT+ +VL V ++CW P +++ A + + KA F ++ L NS++NPVIY Sbjct: 244 AKTLGLVLAVLLICWFPVLALMAHSLATTLSD--QVKKAFAFCSMLCLINSMVNPVIYAL 301 Query: 291 RSRDLRREVLRPLQCWR 307 RS ++R L W+ Sbjct: 302 RSGEIRSSAHHCLAHWK 318 >gi|237681179 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 103 bits (257), Expect = 2e-22 Identities = 84/295 (28%), Positives = 139/295 (47%), Gaps = 33/295 (11%) Query: 32 SRQVASAFIVI-LCCAIVVENLLVLIAVARNSKFHSA-MYLFLGNLAASDLLAGVAFVAN 89 S+Q+A A + + L V+ENLLVL + + Y F+G+LA +DLL V FV + Sbjct: 114 SQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYS 173 Query: 90 TLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSC-RM 148 + + + + + G + +ASV SL AI+R+++I + Y + + Sbjct: 174 FIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKA 233 Query: 149 LLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVAL 208 ++ W I++V+ LP+LGWNC CS + P + Y++ + + S++LL IV Sbjct: 234 VVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYA 293 Query: 209 YVRIYCVVRSSHADM-------------------------AAPQTLALLKTVTIVLGVFI 243 Y+ I S M A + L KT+ ++L V I Sbjct: 294 YMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLI 353 Query: 244 VCWLPAFSILLLDYACPVHSCPILYKAHYFFA--VSTLNSLLNPVIYTWRSRDLR 296 +CW P +I++ D ++ L K + F + LNS +NP+IY RS+DLR Sbjct: 354 ICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405 >gi|237681175 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 103 bits (257), Expect = 2e-22 Identities = 84/295 (28%), Positives = 139/295 (47%), Gaps = 33/295 (11%) Query: 32 SRQVASAFIVI-LCCAIVVENLLVLIAVARNSKFHSA-MYLFLGNLAASDLLAGVAFVAN 89 S+Q+A A + + L V+ENLLVL + + Y F+G+LA +DLL V FV + Sbjct: 114 SQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYS 173 Query: 90 TLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSC-RM 148 + + + + + G + +ASV SL AI+R+++I + Y + + Sbjct: 174 FIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKA 233 Query: 149 LLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVAL 208 ++ W I++V+ LP+LGWNC CS + P + Y++ + + S++LL IV Sbjct: 234 VVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYA 293 Query: 209 YVRIYCVVRSSHADM-------------------------AAPQTLALLKTVTIVLGVFI 243 Y+ I S M A + L KT+ ++L V I Sbjct: 294 YMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLI 353 Query: 244 VCWLPAFSILLLDYACPVHSCPILYKAHYFFA--VSTLNSLLNPVIYTWRSRDLR 296 +CW P +I++ D ++ L K + F + LNS +NP+IY RS+DLR Sbjct: 354 ICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405 >gi|237681173 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 103 bits (257), Expect = 2e-22 Identities = 84/295 (28%), Positives = 139/295 (47%), Gaps = 33/295 (11%) Query: 32 SRQVASAFIVI-LCCAIVVENLLVLIAVARNSKFHSA-MYLFLGNLAASDLLAGVAFVAN 89 S+Q+A A + + L V+ENLLVL + + Y F+G+LA +DLL V FV + Sbjct: 114 SQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYS 173 Query: 90 TLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSC-RM 148 + + + + + G + +ASV SL AI+R+++I + Y + + Sbjct: 174 FIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKA 233 Query: 149 LLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVAL 208 ++ W I++V+ LP+LGWNC CS + P + Y++ + + S++LL IV Sbjct: 234 VVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYA 293 Query: 209 YVRIYCVVRSSHADM-------------------------AAPQTLALLKTVTIVLGVFI 243 Y+ I S M A + L KT+ ++L V I Sbjct: 294 YMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLI 353 Query: 244 VCWLPAFSILLLDYACPVHSCPILYKAHYFFA--VSTLNSLLNPVIYTWRSRDLR 296 +CW P +I++ D ++ L K + F + LNS +NP+IY RS+DLR Sbjct: 354 ICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405 >gi|237681067 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 103 bits (257), Expect = 2e-22 Identities = 84/295 (28%), Positives = 139/295 (47%), Gaps = 33/295 (11%) Query: 32 SRQVASAFIVI-LCCAIVVENLLVLIAVARNSKFHSA-MYLFLGNLAASDLLAGVAFVAN 89 S+Q+A A + + L V+ENLLVL + + Y F+G+LA +DLL V FV + Sbjct: 114 SQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYS 173 Query: 90 TLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSC-RM 148 + + + + + G + +ASV SL AI+R+++I + Y + + Sbjct: 174 FIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKA 233 Query: 149 LLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVAL 208 ++ W I++V+ LP+LGWNC CS + P + Y++ + + S++LL IV Sbjct: 234 VVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYA 293 Query: 209 YVRIYCVVRSSHADM-------------------------AAPQTLALLKTVTIVLGVFI 243 Y+ I S M A + L KT+ ++L V I Sbjct: 294 YMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLI 353 Query: 244 VCWLPAFSILLLDYACPVHSCPILYKAHYFFA--VSTLNSLLNPVIYTWRSRDLR 296 +CW P +I++ D ++ L K + F + LNS +NP+IY RS+DLR Sbjct: 354 ICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405 >gi|38683844 cannabinoid receptor 1 isoform a [Homo sapiens] Length = 472 Score = 103 bits (257), Expect = 2e-22 Identities = 84/295 (28%), Positives = 139/295 (47%), Gaps = 33/295 (11%) Query: 32 SRQVASAFIVI-LCCAIVVENLLVLIAVARNSKFHSA-MYLFLGNLAASDLLAGVAFVAN 89 S+Q+A A + + L V+ENLLVL + + Y F+G+LA +DLL V FV + Sbjct: 114 SQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYS 173 Query: 90 TLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSC-RM 148 + + + + + G + +ASV SL AI+R+++I + Y + + Sbjct: 174 FIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKA 233 Query: 149 LLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVAL 208 ++ W I++V+ LP+LGWNC CS + P + Y++ + + S++LL IV Sbjct: 234 VVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYA 293 Query: 209 YVRIYCVVRSSHADM-------------------------AAPQTLALLKTVTIVLGVFI 243 Y+ I S M A + L KT+ ++L V I Sbjct: 294 YMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLI 353 Query: 244 VCWLPAFSILLLDYACPVHSCPILYKAHYFFA--VSTLNSLLNPVIYTWRSRDLR 296 +CW P +I++ D ++ L K + F + LNS +NP+IY RS+DLR Sbjct: 354 ICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 405 >gi|237681065 cannabinoid receptor 1 isoform b [Homo sapiens] Length = 439 Score = 103 bits (257), Expect = 2e-22 Identities = 84/295 (28%), Positives = 139/295 (47%), Gaps = 33/295 (11%) Query: 32 SRQVASAFIVI-LCCAIVVENLLVLIAVARNSKFHSA-MYLFLGNLAASDLLAGVAFVAN 89 S+Q+A A + + L V+ENLLVL + + Y F+G+LA +DLL V FV + Sbjct: 81 SQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYS 140 Query: 90 TLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSC-RM 148 + + + + + G + +ASV SL AI+R+++I + Y + + Sbjct: 141 FIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKA 200 Query: 149 LLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVAL 208 ++ W I++V+ LP+LGWNC CS + P + Y++ + + S++LL IV Sbjct: 201 VVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYA 260 Query: 209 YVRIYCVVRSSHADM-------------------------AAPQTLALLKTVTIVLGVFI 243 Y+ I S M A + L KT+ ++L V I Sbjct: 261 YMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLI 320 Query: 244 VCWLPAFSILLLDYACPVHSCPILYKAHYFFA--VSTLNSLLNPVIYTWRSRDLR 296 +CW P +I++ D ++ L K + F + LNS +NP+IY RS+DLR Sbjct: 321 ICWGPLLAIMVYDVFGKMNK---LIKTVFAFCSMLCLLNSTVNPIIYALRSKDLR 372 >gi|193083134 melanocortin 1 receptor [Homo sapiens] Length = 317 Score = 98.6 bits (244), Expect = 7e-21 Identities = 86/294 (29%), Positives = 136/294 (46%), Gaps = 41/294 (13%) Query: 35 VASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANT---- 90 ++ + L +VEN LV+ +A+N HS MY F+ LA SDLL + V T Sbjct: 40 ISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVIL 99 Query: 91 -LLSGSVTLRLTPVQWFAREGSAFITLSASVFSLL---AIAIERHVAIAKVKLYGSDKSC 146 L +G++ R +Q IT S+ + SL AIA++R+++I Y S + Sbjct: 100 LLEAGALVARAAVLQQLDNVIDV-ITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTL 158 Query: 147 -RMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKH--YVLCVVTIFSIILL 203 R + A W+ S+V ST+ Y H +LC+V F +L+ Sbjct: 159 PRARRAVAAIWVASVVF-----------------STLFIAYYDHVAVLLCLVVFFLAMLV 201 Query: 204 AIVALYVRIYC--------VVRSSHADMAAPQTLAL--LKTVTIVLGVFIVCWLPAFSIL 253 + LYV + + R Q L T+TI+LG+F +CW P F L Sbjct: 202 LMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHL 261 Query: 254 LLDYACPVH-SCPILYK-AHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQC 305 L CP H +C ++K + F A+ N++++P+IY + S++LRR + L C Sbjct: 262 TLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTC 315 >gi|5921992 adenosine A2a receptor [Homo sapiens] Length = 412 Score = 97.1 bits (240), Expect = 2e-20 Identities = 82/294 (27%), Positives = 135/294 (45%), Gaps = 50/294 (17%) Query: 48 VVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFV--ANTLLSGSVTLRLTPVQW 105 ++ N+LV AV NS + F+ +LAA+D+ GV + A T+ +G Sbjct: 21 ILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCA-------- 72 Query: 106 FAREGSAFITL------SASVFSLLAIAIERHVAIA-KVKLYGSDKSCRMLLLIGASWLI 158 A G FI +S+FSLLAIAI+R++AI ++ G R +I W++ Sbjct: 73 -ACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVL 131 Query: 159 SLVLGGLPILGWNCLG-------HLEACST---------VLPLYAKHYVLCVVTIFSIIL 202 S +G P+LGWN G H + C V+P+ Y + + L Sbjct: 132 SFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVL-VPL 190 Query: 203 LAIVALYVRIYCVVRSSHADMAAP------------QTLALLKTVTIVLGVFIVCWLPAF 250 L ++ +Y+RI+ R M + + + K++ I++G+F +CWLP Sbjct: 191 LLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLH 250 Query: 251 SILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLR---REVLR 301 I + CP S L+ + +S NS++NP IY +R R+ R R+++R Sbjct: 251 IINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIR 304 >gi|4505127 melanocortin 2 receptor [Homo sapiens] Length = 297 Score = 92.0 bits (227), Expect = 7e-19 Identities = 82/280 (29%), Positives = 135/280 (48%), Gaps = 43/280 (15%) Query: 48 VVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLR----LTPV 103 V+ENL+VL+AV +N + MY F+ +LA SD+L + + +L + LR L P Sbjct: 39 VLENLIVLLAVFKNKNLQAPMYFFICSLAISDMLGSLYKILENIL---IILRNMGYLKPR 95 Query: 104 QWFAREGSAFI------TLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWL 157 F I +L S+FSL IA +R++ I Y S + R +++ Sbjct: 96 GSFETTADDIIDSLFVLSLLGSIFSLSVIAADRYITIFHALRYHSIVTMRRTVVV----- 150 Query: 158 ISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVT---IFSIILLAIVALYVRIYC 214 L ++ C G + + + H+V V+T +F ++L+ I+ LYV ++ Sbjct: 151 -------LTVIWTFCTG-----TGITMVIFSHHVPTVITFTSLFPLMLVFILCLYVHMFL 198 Query: 215 VVRSSHADMAAPQTLALLK---TVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAH 271 + R SH + A +K T+TI+LGVFI CW P +LL CP + Y + Sbjct: 199 LAR-SHTRKISTLPRANMKGAITLTILLGVFIFCWAPFVLHVLLMTFCPSNPYCACYMS- 256 Query: 272 YFFAVSTL----NSLLNPVIYTWRSRDLRREVLRPLQCWR 307 F V+ + N++++P IY +RS +LR + + C R Sbjct: 257 -LFQVNGMLIMCNAVIDPFIYAFRSPELRDAFKKMIFCSR 295 >gi|4501951 adenosine A2b receptor [Homo sapiens] Length = 332 Score = 82.0 bits (201), Expect = 7e-16 Identities = 70/303 (23%), Positives = 136/303 (44%), Gaps = 38/303 (12%) Query: 25 LETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGV 84 LETQ+ + A +++ V N+LV AV + + FL +LAA+D+ G+ Sbjct: 3 LETQDA----LYVALELVIAALSVAGNVLVCAAVGTANTLQTPTNYFLVSLAAADVAVGL 58 Query: 85 AFVANTLLSGSVTLRLTPVQWFAREGSAFITL--SASVFSLLAIAIERHVAIAKVKLYGS 142 + + +++L + + F+ + +S+FSLLA+A++R++AI Y S Sbjct: 59 FAIPFAI---TISLGFCTDFYGCLFLACFVLVLTQSSIFSLLAVAVDRYLAICVPLRYKS 115 Query: 143 -DKSCRMLLLIGASWLISLVLGGLPILGWNCLGHL-------------EACSTVLPLYAK 188 R +I W+++ +G P LGWN E+C V L+ Sbjct: 116 LVTGTRARGVIAVLWVLAFGIGLTPFLGWNSKDSATNNCTEPWDGTTNESCCLVKCLFEN 175 Query: 189 HYVLCVVTIFSII------LLAIVALYVRIYCVV--------RSSHADMAAPQTLALLKT 234 + + F+ LL ++ +Y++I+ V H+ + + K+ Sbjct: 176 VVPMSYMVYFNFFGCVLPPLLIMLVIYIKIFLVACRQLQRTELMDHSRTTLQREIHAAKS 235 Query: 235 VTIVLGVFIVCWLPAFSILLLDYACPVHSC-PILYKAHYFFAVSTLNSLLNPVIYTWRSR 293 + +++G+F +CWLP ++ + P + + +S NS++NP++Y +R+R Sbjct: 236 LAMIVGIFALCWLPVHAVNCVTLFQPAQGKNKPKWAMNMAILLSHANSVVNPIVYAYRNR 295 Query: 294 DLR 296 D R Sbjct: 296 DFR 298 >gi|5174593 melatonin receptor 1A [Homo sapiens] Length = 350 Score = 81.3 bits (199), Expect = 1e-15 Identities = 82/291 (28%), Positives = 138/291 (47%), Gaps = 32/291 (10%) Query: 35 VASAFIVILCCAIVVE---NLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTL 91 +ASA +L IVV+ NLLV+++V RN K +A +F+ +LA +DL+ VA L Sbjct: 26 LASALACVLIFTIVVDILGNLLVILSVYRNKKLRNAGNIFVVSLAVADLV--VAIYPYPL 83 Query: 92 LSGSVTLRLTPVQWFAREGSAF---ITLSASVFSLLAIAIERHVAIAKV----KLYGSDK 144 + S+ + + + S F +++ S+F++ IAI R+ I KLY S Sbjct: 84 VLMSIFNNGWNLGYLHCQVSGFLMGLSVIGSIFNITGIAINRYCYICHSLKYDKLYSSKN 143 Query: 145 SCRMLLLIGASWLISLVLGGLPILGWNCLGH---LEACSTVLPLYAKHYVLCVVTIFSII 201 S +LLI WL++L LP L L + + +C+ + + + + VV F + Sbjct: 144 SLCYVLLI---WLLTLA-AVLPNLRAGTLQYDPRIYSCTFAQSVSSAYTIAVVVFHFLVP 199 Query: 202 LLAIVALYVRIYCV-------VRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILL 254 ++ ++ Y+RI+ + V+ PQ T+ +V +F +CW P I L Sbjct: 200 MIIVIFCYLRIWILVLQVRQRVKPDRKPKLKPQDFRNFVTMFVVFVLFAICWAPLNFIGL 259 Query: 255 LDYACPVHSCP----ILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLR 301 + P P L+ A Y+ A NS LN +IY +++ R+E R Sbjct: 260 AVASDPASMVPRIPEWLFVASYYMAY--FNSCLNAIIYGLLNQNFRKEYRR 308 >gi|5174595 melatonin receptor 1B [Homo sapiens] Length = 362 Score = 80.5 bits (197), Expect = 2e-15 Identities = 86/304 (28%), Positives = 144/304 (47%), Gaps = 30/304 (9%) Query: 37 SAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSV 96 SA +++ VV NLLV+++V RN K +A LFL +LA +DL+ VAF L+ ++ Sbjct: 44 SAVLIVTTAVDVVGNLLVILSVLRNRKLRNAGNLFLVSLALADLV--VAFYPYPLILVAI 101 Query: 97 TLRLTPVQWFAREGSAFI---TLSASVFSLLAIAIERHVAIAKVKLYGS-DKSCRMLLLI 152 + + SAF+ ++ SVF++ AIAI R+ I Y + L I Sbjct: 102 FYDGWALGEEHCKASAFVMGLSVIGSVFNITAIAINRYCYICHSMAYHRIYRRWHTPLHI 161 Query: 153 GASWLISLVLGGLPILGWNCLGHLE------ACSTVLPLYAKHYVLCVVTIFSIILLAIV 206 WL+++V +L +G LE +C T + + Y VV I ++ +A+V Sbjct: 162 CLIWLLTVV----ALLPNFFVGSLEYDPRIYSC-TFIQTASTQYTAAVVVIHFLLPIAVV 216 Query: 207 AL-YVRIYCVVRSSHADMAAPQTLALLK--------TVTIVLGVFIVCWLPAFSILLLDY 257 + Y+RI+ +V + A P++ LK T+ +V +F +CW P I L Sbjct: 217 SFCYLRIWVLVLQARR-KAKPESRLCLKPSDLRSFLTMFVVFVIFAICWAPLNCIGLAVA 275 Query: 258 ACPVHSCPILYKAHYF--FAVSTLNSLLNPVIYTWRSRDLRREVLR-PLQCWRPGVGVQG 314 P P + + + + ++ NS LN ++Y +++ RRE R L W P +Q Sbjct: 276 INPQEMAPQIPEGLFVTSYLLAYFNSCLNAIVYGLLNQNFRREYKRILLALWNPRHCIQD 335 Query: 315 RRRG 318 +G Sbjct: 336 ASKG 339 >gi|115305569 adenosine A1 receptor [Homo sapiens] Length = 326 Score = 77.8 bits (190), Expect = 1e-14 Identities = 69/294 (23%), Positives = 130/294 (44%), Gaps = 42/294 (14%) Query: 41 VILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRL 100 V++ V N+LV+ AV N A + F+ +LA +D+ G + +L + + Sbjct: 17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL-----INI 71 Query: 101 TPVQWFAR----EGSAFITLSASVFSLLAIAIERHVAIA---KVKLYGSDKSCRMLLLIG 153 P +F I +S+ +LLAIA++R++ + + K+ + + R + I Sbjct: 72 GPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPR--RAAVAIA 129 Query: 154 ASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLC----VVTIFSII-------- 201 W++S V+G P+ GWN L +E + + C V+++ ++ Sbjct: 130 GCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWV 189 Query: 202 ---LLAIVALYVRIYCVVRSS-----HADMAAPQ-----TLALLKTVTIVLGVFIVCWLP 248 LL +V +Y+ ++ ++R A PQ L + K++ ++L +F + WLP Sbjct: 190 LPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP 249 Query: 249 AFSILLLDYACP-VHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLR 301 + + CP H IL F NS +NP++Y +R + R L+ Sbjct: 250 LHILNCITLFCPSCHKPSILTYIAIFLTHG--NSAMNPIVYAFRIQKFRVTFLK 301 >gi|4501947 adenosine A1 receptor [Homo sapiens] Length = 326 Score = 77.8 bits (190), Expect = 1e-14 Identities = 69/294 (23%), Positives = 130/294 (44%), Gaps = 42/294 (14%) Query: 41 VILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRL 100 V++ V N+LV+ AV N A + F+ +LA +D+ G + +L + + Sbjct: 17 VLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAIL-----INI 71 Query: 101 TPVQWFAR----EGSAFITLSASVFSLLAIAIERHVAIA---KVKLYGSDKSCRMLLLIG 153 P +F I +S+ +LLAIA++R++ + + K+ + + R + I Sbjct: 72 GPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKMVVTPR--RAAVAIA 129 Query: 154 ASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLC----VVTIFSII-------- 201 W++S V+G P+ GWN L +E + + C V+++ ++ Sbjct: 130 GCWILSFVVGLTPMFGWNNLSAVERAWAANGSMGEPVIKCEFEKVISMEYMVYFNFFVWV 189 Query: 202 ---LLAIVALYVRIYCVVRSS-----HADMAAPQ-----TLALLKTVTIVLGVFIVCWLP 248 LL +V +Y+ ++ ++R A PQ L + K++ ++L +F + WLP Sbjct: 190 LPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLP 249 Query: 249 AFSILLLDYACP-VHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLR 301 + + CP H IL F NS +NP++Y +R + R L+ Sbjct: 250 LHILNCITLFCPSCHKPSILTYIAIFLTHG--NSAMNPIVYAFRIQKFRVTFLK 301 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.327 0.139 0.427 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 12,268,765 Number of Sequences: 37866 Number of extensions: 502194 Number of successful extensions: 3213 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 346 Number of HSP's successfully gapped in prelim test: 370 Number of HSP's that attempted gapping in prelim test: 2027 Number of HSP's gapped (non-prelim): 860 length of query: 353 length of database: 18,247,518 effective HSP length: 103 effective length of query: 250 effective length of database: 14,347,320 effective search space: 3586830000 effective search space used: 3586830000 T: 11 A: 40 X1: 15 ( 7.1 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 40 (21.7 bits) S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.