Guide to the Human Genome
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Search of human proteins with 54144625

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|54144625 numb homolog isoform 1 [Homo sapiens]
         (651 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|54144625 numb homolog isoform 1 [Homo sapiens]                    1323   0.0  
gi|20070356 numb homolog isoform 3 [Homo sapiens]                    1291   0.0  
gi|54144627 numb homolog isoform 2 [Homo sapiens]                    1202   0.0  
gi|54144629 numb homolog isoform 4 [Homo sapiens]                    1170   0.0  
gi|10863899 numb homolog (Drosophila)-like [Homo sapiens]             566   e-161
gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Hom...    84   5e-16
gi|132626790 low density lipoprotein receptor adaptor protein 1 ...    74   3e-13
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             57   5e-08
gi|50511947 cajalin 2 isoform b [Homo sapiens]                         57   7e-08
gi|50511945 cajalin 2 isoform a [Homo sapiens]                         57   7e-08
gi|10047134 cajalin 2 isoform c [Homo sapiens]                         57   7e-08
gi|33350928 disabled homolog 1 [Homo sapiens]                          55   2e-07
gi|140161500 ankyrin repeat and sterile alpha motif domain conta...    54   3e-07
gi|239743232 PREDICTED: hypothetical protein XP_002342775 [Homo ...    51   4e-06
gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein i...    50   7e-06
gi|26051278 nuclear pore membrane protein 121 [Homo sapiens]           50   7e-06
gi|19111150 angiomotin isoform 2 [Homo sapiens]                        49   1e-05
gi|166064029 angiomotin isoform 1 [Homo sapiens]                       49   1e-05
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         48   2e-05
gi|148491082 disabled homolog 2 [Homo sapiens]                         47   4e-05
gi|150378545 POM121 membrane glycoprotein (rat)-like [Homo sapiens]    47   6e-05
gi|21327715 transcription elongation regulator 1 isoform 1 [Homo...    46   9e-05
gi|91208420 bassoon protein [Homo sapiens]                             45   2e-04
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   44   5e-04
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   44   5e-04
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   44   5e-04
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    44   5e-04
gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    44   5e-04
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    44   5e-04
gi|91208418 transcription elongation regulator 1 isoform 2 [Homo...    44   5e-04

>gi|54144625 numb homolog isoform 1 [Homo sapiens]
          Length = 651

 Score = 1323 bits (3425), Expect = 0.0
 Identities = 651/651 (100%), Positives = 651/651 (100%)

Query: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED 60
           MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED
Sbjct: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED 60

Query: 61  AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD 120
           AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD
Sbjct: 61  AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD 120

Query: 121 RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA 180
           RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA
Sbjct: 121 RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA 180

Query: 181 TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS 240
           TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS
Sbjct: 181 TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS 240

Query: 241 SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE 300
           SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE
Sbjct: 241 SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE 300

Query: 301 LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ 360
           LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ
Sbjct: 301 LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ 360

Query: 361 SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS 420
           SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS
Sbjct: 361 SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS 420

Query: 421 SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS 480
           SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS
Sbjct: 421 SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS 480

Query: 481 PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG 540
           PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG
Sbjct: 481 PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG 540

Query: 541 TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA 600
           TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA
Sbjct: 541 TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA 600

Query: 601 DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 651
           DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
Sbjct: 601 DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 651


>gi|20070356 numb homolog isoform 3 [Homo sapiens]
          Length = 640

 Score = 1291 bits (3342), Expect = 0.0
 Identities = 640/651 (98%), Positives = 640/651 (98%), Gaps = 11/651 (1%)

Query: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED 60
           MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED
Sbjct: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED 60

Query: 61  AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD 120
           AVKRLKA           TGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD
Sbjct: 61  AVKRLKA-----------TGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD 109

Query: 121 RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA 180
           RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA
Sbjct: 110 RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA 169

Query: 181 TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS 240
           TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS
Sbjct: 170 TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS 229

Query: 241 SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE 300
           SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE
Sbjct: 230 SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE 289

Query: 301 LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ 360
           LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ
Sbjct: 290 LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ 349

Query: 361 SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS 420
           SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS
Sbjct: 350 SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS 409

Query: 421 SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS 480
           SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS
Sbjct: 410 SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS 469

Query: 481 PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG 540
           PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG
Sbjct: 470 PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG 529

Query: 541 TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA 600
           TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA
Sbjct: 530 TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA 589

Query: 601 DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 651
           DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
Sbjct: 590 DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 640


>gi|54144627 numb homolog isoform 2 [Homo sapiens]
          Length = 603

 Score = 1202 bits (3111), Expect = 0.0
 Identities = 603/651 (92%), Positives = 603/651 (92%), Gaps = 48/651 (7%)

Query: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED 60
           MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED
Sbjct: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED 60

Query: 61  AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD 120
           AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD
Sbjct: 61  AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD 120

Query: 121 RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA 180
           RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA
Sbjct: 121 RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA 180

Query: 181 TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS 240
           TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS
Sbjct: 181 TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS 240

Query: 241 SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE 300
           SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE
Sbjct: 241 SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE 300

Query: 301 LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ 360
           LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ
Sbjct: 301 LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ 360

Query: 361 SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS 420
           SPTFQ                                                GTEWGQS
Sbjct: 361 SPTFQ------------------------------------------------GTEWGQS 372

Query: 421 SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS 480
           SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS
Sbjct: 373 SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS 432

Query: 481 PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG 540
           PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG
Sbjct: 433 PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG 492

Query: 541 TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA 600
           TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA
Sbjct: 493 TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA 552

Query: 601 DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 651
           DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
Sbjct: 553 DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 603


>gi|54144629 numb homolog isoform 4 [Homo sapiens]
          Length = 592

 Score = 1170 bits (3028), Expect = 0.0
 Identities = 592/651 (90%), Positives = 592/651 (90%), Gaps = 59/651 (9%)

Query: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED 60
           MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED
Sbjct: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED 60

Query: 61  AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD 120
           AVKRLKA           TGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD
Sbjct: 61  AVKRLKA-----------TGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD 109

Query: 121 RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA 180
           RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA
Sbjct: 110 RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA 169

Query: 181 TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS 240
           TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS
Sbjct: 170 TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS 229

Query: 241 SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE 300
           SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE
Sbjct: 230 SPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLRINE 289

Query: 301 LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ 360
           LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ
Sbjct: 290 LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQ 349

Query: 361 SPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQS 420
           SPTFQ                                                GTEWGQS
Sbjct: 350 SPTFQ------------------------------------------------GTEWGQS 361

Query: 421 SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS 480
           SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS
Sbjct: 362 SGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPAS 421

Query: 481 PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG 540
           PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG
Sbjct: 422 PFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFG 481

Query: 541 TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA 600
           TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA
Sbjct: 482 TAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDGRLASA 541

Query: 601 DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 651
           DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL
Sbjct: 542 DRHTEVPTGTCPVDPFEAQWAALENKSKQRTNPSPTNPFSSDLQKTFEIEL 592


>gi|10863899 numb homolog (Drosophila)-like [Homo sapiens]
          Length = 609

 Score =  566 bits (1458), Expect = e-161
 Identities = 350/683 (51%), Positives = 405/683 (59%), Gaps = 147/683 (21%)

Query: 1   MNKLRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICED 60
           MNKLRQS RR+K  YVPEASRPHQWQ DE+ VR G CSFPV+YLGHVEV+ESRGMH+CED
Sbjct: 42  MNKLRQSLRRRKPAYVPEASRPHQWQADEDAVRKGTCSFPVRYLGHVEVEESRGMHVCED 101

Query: 61  AVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPD 120
           AVK+LKA            G+K+VK+VLWVSADGLRVVD+KTKDL+VDQTIEKVSFCAPD
Sbjct: 102 AVKKLKA-----------MGRKSVKSVLWVSADGLRVVDDKTKDLLVDQTIEKVSFCAPD 150

Query: 121 RNFDRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTA 180
           RN D+AFSYICRDGTTRRWICHCF+A+KD+GERLSHAVGCAFAACLERKQ+REKECGVTA
Sbjct: 151 RNLDKAFSYICRDGTTRRWICHCFLALKDSGERLSHAVGCAFAACLERKQRREKECGVTA 210

Query: 181 TFDASRTTFTREGSFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPS 240
            FDASRT+F REGSFR++     AERE       D KKAE        +VAPG   P   
Sbjct: 211 AFDASRTSFAREGSFRLSGGGRPAERE-----APDKKKAEA---AAAPTVAPGPAQPGHV 262

Query: 241 SPTSPTSDATTSLEMNNP-------HAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQ 293
           SPT  T+      E   P        AIPRRHAP+EQL RQGSFRGFPALSQK SPFKRQ
Sbjct: 263 SPTPATTSPGEKGEAGTPVAAGTTAAAIPRRHAPLEQLVRQGSFRGFPALSQKNSPFKRQ 322

Query: 294 LSLRINELPSTMQRKTDFPIKNAVPEVE----GEAESISSLCSQITNAFSTPEDPFSSAP 349
           LSLR+NELPST+QR+TDF +K  VPE+E    G+++SI++LC+QI+++F++   P   AP
Sbjct: 323 LSLRLNELPSTLQRRTDFQVKGTVPEMEPPGAGDSDSINALCTQISSSFASAGAP---AP 379

Query: 350 MTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIA 409
              P T            GT SA+   + P   A  P                       
Sbjct: 380 GPPPAT-----------TGT-SAWGEPSVPPAAAFQP----------------------- 404

Query: 410 ATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQ------------ 457
                                 GH+RTPSEA+RWLEEVS+  +AQQ Q            
Sbjct: 405 ----------------------GHKRTPSEAERWLEEVSQVAKAQQQQQQQQQQQQQQQQ 442

Query: 458 -----ASAAP---LQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQ 509
                AS AP   + P LQP P       A+P Q   FL          P +QP FVPA 
Sbjct: 443 QQQQAASVAPVPTMPPALQPFPAPVGPFDAAPAQVAVFLPP--------PHMQPPFVPA- 493

Query: 510 SYPVANGMPY-PAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEAS 568
            YP   G+ Y P P VPVVGITPSQMVAN F +A   Q   P  +  L +   FP     
Sbjct: 494 -YP---GLGYPPMPRVPVVGITPSQMVANAFCSAAQLQ---PQPATLLGKAGAFPPPAIP 546

Query: 569 SATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALENKSK 628
           SA  S     P    NG+                    P     +DPFEAQWAALE K+ 
Sbjct: 547 SAPGSQARPRP----NGAPW-------------PPEPAPAPAPELDPFEAQWAALEGKA- 588

Query: 629 QRTNPSPTNPFSSDLQKTFEIEL 651
             T   P+NPFS DLQKTFEIEL
Sbjct: 589 --TVEKPSNPFSGDLQKTFEIEL 609


>gi|7705318 GULP, engulfment adaptor PTB domain containing 1 [Homo
           sapiens]
          Length = 304

 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 63/264 (23%), Positives = 125/264 (47%), Gaps = 31/264 (11%)

Query: 4   LRQSFRRKKDVYVPEASRPHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVK 63
           + ++F RKKD           W    E +      +  K+LG  EV++ +G  +  DAV+
Sbjct: 1   MNRAFSRKKD---------KTWMHTPEALSKHFIPYNAKFLGSTEVEQPKGTEVVRDAVR 51

Query: 64  RLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNF 123
           +LK  R   K      G+K  K  L +S  G+++++ KTK++  +  + ++SFCA D+  
Sbjct: 52  KLKFARHIKKS----EGQKIPKVELQISIYGVKILEPKTKEVQHNCQLHRISFCADDKTD 107

Query: 124 DRAFSYICRDGTTRRWICHCFMAVKDTGERLSHAVGCAFAACLERKQKREKECGVTATFD 183
            R F++IC+D  + + +C+ F + K   E ++  +G AF    +   ++  E G      
Sbjct: 108 KRIFTFICKDSESNKHLCYVFDSEK-CAEEITLTIGQAF----DLAYRKFLESG------ 156

Query: 184 ASRTTFTREGSFRVTTATEQAERE--EIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSS 241
             +   TR+    +    +  E E  E+  ++QD +    +++ +    AP   + +P S
Sbjct: 157 -GKDVETRKQIAGLQKRIQDLETENMELKNKVQDLE----NQLRITQVSAPPAGSMTPKS 211

Query: 242 PTSPTSDATTSLEMNNPHAIPRRH 265
           P++   D      +++  ++P R+
Sbjct: 212 PSTDIFDMIPFSPISHQSSMPTRN 235


>gi|132626790 low density lipoprotein receptor adaptor protein 1
           [Homo sapiens]
          Length = 308

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 63/243 (25%), Positives = 103/243 (42%), Gaps = 35/243 (14%)

Query: 22  PHQWQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGK 81
           P  W    E +  G   F +KYLG   V++ +G  +   A+KR+ A  K        +GK
Sbjct: 32  PENWTDTRETLLEGML-FSLKYLGMTLVEQPKGEELSAAAIKRIVATAK-------ASGK 83

Query: 82  KAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWIC 141
           K  K  L VS  G+ + D  T  LI + +I ++S+C  D+  D+ F+YI +    +   C
Sbjct: 84  KLQKVTLKVSPRGIILTDNLTNQLIENVSIYRISYCTADKMHDKVFAYIAQSQHNQSLEC 143

Query: 142 HCFMAVK-DTGERLSHAVGCAFAACLE--RKQKREKECGVTATFDASRTTFTREGSFRVT 198
           H F+  K    + ++  V  AF    E  +  K EKE          R   ++EG     
Sbjct: 144 HAFLCTKRKMAQAVTLTVAQAFKVAFEFWQVSKEEKE---------KRDKASQEGG---- 190

Query: 199 TATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNP 258
                    +++   QD   +    +  G+ +    TA +P S  S  ++ T   E+  P
Sbjct: 191 ---------DVLGARQDCTPSLKSLVATGNLLDLEETAKAPLSTVS--ANTTNMDEVPRP 239

Query: 259 HAI 261
            A+
Sbjct: 240 QAL 242


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 57.0 bits (136), Expect = 5e-08
 Identities = 80/352 (22%), Positives = 126/352 (35%), Gaps = 38/352 (10%)

Query: 231  APGNTAPSPSSPTSPTSDATTSLEMNNPHA-IPRRHAPIEQLARQGSFRGFPALSQKMSP 289
            +P    P+P  PTSP +   T  E  +P A +P    P    A        P   +  SP
Sbjct: 1041 SPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAA------AVPTPEEPTSP 1094

Query: 290  FKRQLSLRINELPSTMQRKTDFPIKNA--VPEVEGEAESISSLCSQITNAFSTPEDPFSS 347
                 +      P+      + P   A  VP  E  A   +++ +    AF  P  P   
Sbjct: 1095 AAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPE 1154

Query: 348  APMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTA--LAPVAMPVRETNPWAHAPDAAN 405
               +  V V  P+     A    +       PA +A   A VA     T+P A  P  A 
Sbjct: 1155 ESASAAVAVPTPEESASPAAAVPT-------PAESASFAAVVATLEEPTSPAASVPTPAA 1207

Query: 406  -----KEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQ-QPQAS 459
                 +E  +  +     +   + +  +       +P+ A   LEE + S  A   P+  
Sbjct: 1208 MVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPEEL 1267

Query: 460  AAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPY 519
            ++P   V  P       +PASP    + L     P   VP  + A +PA S P       
Sbjct: 1268 SSPAASVPTP------EEPASPAAAVSNLEEPASPAAAVPTPEVAAIPAASVPTPE---- 1317

Query: 520  PAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSAT 571
              P +P   + P + V+ + G      +AH    P  + ++  P  E +S+T
Sbjct: 1318 -VPAIPAAAVPPMEEVSPI-GVPFLGVSAHTDSVP--ISEEGTPVLEEASST 1365



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 76/310 (24%), Positives = 107/310 (34%), Gaps = 36/310 (11%)

Query: 340  TPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRE--TNPW 397
            T ED     P+T   TV AP+ P       D+A   ++ P   A    A+P  E  T+P 
Sbjct: 965  TEEDGTPEGPVTPATTVHAPEEP-------DTAAVRVSTPEEPASPAAAVPTPEEPTSPA 1017

Query: 398  AHAPDAAN-KEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRA--- 453
            A  P        AA     E   S  AA P         +P+ A    EE +    A   
Sbjct: 1018 AAVPTPEEPTSPAAAVPPPEEPTSPAAAVP---TPEEPTSPAAAVPTPEEPTSPAAAVPT 1074

Query: 454  -QQPQASAAPLQPVLQPPPPTAI----SQPASPFQGNAFLTSQPVPVGVVPALQPAFVPA 508
             ++P + AA +    +P  P A      +P SP            P   VP  +    PA
Sbjct: 1075 PEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPA 1134

Query: 509  QSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEAS 568
             + P      +PAP VP    + S  VA             P +S S       P   AS
Sbjct: 1135 AAVPTPEEPAFPAPAVPTPEESASAAVA----------VPTPEESASPAAAVPTPAESAS 1184

Query: 569  SATTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALENKSK 628
             A      + P       AA        +A+ +  T  P  + P     A  AA  +  +
Sbjct: 1185 FAAVVATLEEP----TSPAASVPTPAAMVATLEEFTS-PAASVPTSEEPASLAAAVSNPE 1239

Query: 629  QRTNPSPTNP 638
            + T+P+   P
Sbjct: 1240 EPTSPAAAVP 1249


>gi|50511947 cajalin 2 isoform b [Homo sapiens]
          Length = 510

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 38/129 (29%), Positives = 59/129 (45%), Gaps = 5/129 (3%)

Query: 19  ASRPHQ-WQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFG 77
           AS P Q WQ   E +    C +   YLG + + E RG    +DA  +++A  +       
Sbjct: 291 ASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKST---- 346

Query: 78  KTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTR 137
           +  KK    +L VS  G++ +D   K++I +  I  +S  A D      F+YI +D  + 
Sbjct: 347 EQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSN 406

Query: 138 RWICHCFMA 146
              CH F A
Sbjct: 407 HHYCHVFTA 415


>gi|50511945 cajalin 2 isoform a [Homo sapiens]
          Length = 1248

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 38/129 (29%), Positives = 59/129 (45%), Gaps = 5/129 (3%)

Query: 19   ASRPHQ-WQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFG 77
            AS P Q WQ   E +    C +   YLG + + E RG    +DA  +++A  +       
Sbjct: 1041 ASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKST---- 1096

Query: 78   KTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTR 137
            +  KK    +L VS  G++ +D   K++I +  I  +S  A D      F+YI +D  + 
Sbjct: 1097 EQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSN 1156

Query: 138  RWICHCFMA 146
               CH F A
Sbjct: 1157 HHYCHVFTA 1165


>gi|10047134 cajalin 2 isoform c [Homo sapiens]
          Length = 414

 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 38/129 (29%), Positives = 59/129 (45%), Gaps = 5/129 (3%)

Query: 19  ASRPHQ-WQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFG 77
           AS P Q WQ   E +    C +   YLG + + E RG    +DA  +++A  +       
Sbjct: 207 ASTPVQYWQHHPEKLIFQSCDYKAFYLGSMLIKELRGTESTQDACAKMRANCQKST---- 262

Query: 78  KTGKKAVKAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTR 137
           +  KK    +L VS  G++ +D   K++I +  I  +S  A D      F+YI +D  + 
Sbjct: 263 EQMKKVPTIILSVSYKGVKFIDATNKNIIAEHEIRNISCAAQDPEDLSTFAYITKDLKSN 322

Query: 138 RWICHCFMA 146
              CH F A
Sbjct: 323 HHYCHVFTA 331


>gi|33350928 disabled homolog 1 [Homo sapiens]
          Length = 555

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 46/149 (30%), Positives = 71/149 (47%), Gaps = 18/149 (12%)

Query: 30  EGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLW 89
           EGVR     +  K +G  EV  +RG  +C+D++ +LK       G   K G+   K  L 
Sbjct: 38  EGVR-----YKAKLIGIDEVSAARGDKLCQDSMMKLKG---VVAGARSK-GEHKQKIFLT 88

Query: 90  VSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYIC-RDGTTRRWICHCFMAVK 148
           +S  G+++ DEKT  L     + ++S+ A D    RAF Y+C ++G       H F+A+K
Sbjct: 89  ISFGGIKIFDEKTGALQHHHAVHEISYIAKDITDHRAFGYVCGKEGN------HRFVAIK 142

Query: 149 --DTGERLSHAVGCAFAACLERKQKREKE 175
                E +   +   F    E KQ+ E E
Sbjct: 143 TAQAAEPVILDLRDLFQLIYELKQREELE 171


>gi|140161500 ankyrin repeat and sterile alpha motif domain containing
            1 [Homo sapiens]
          Length = 1134

 Score = 54.3 bits (129), Expect = 3e-07
 Identities = 31/123 (25%), Positives = 53/123 (43%), Gaps = 8/123 (6%)

Query: 25   WQTDEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAV 84
            WQ   E +    C +   YLG + + + RG    +DA  +++   +  K        K  
Sbjct: 928  WQHQPEKLIFESCGYEANYLGSMLIKDLRGTESTQDACAKMRKSTEHMK--------KIP 979

Query: 85   KAVLWVSADGLRVVDEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYICRDGTTRRWICHCF 144
              +L ++  G++ +D   K++I +  I  +S  A D      F+YI +D  T    CH F
Sbjct: 980  TIILSITYKGVKFIDASNKNVIAEHEIRNISCAAQDPEDLCTFAYITKDLQTSHHYCHVF 1039

Query: 145  MAV 147
              V
Sbjct: 1040 STV 1042


>gi|239743232 PREDICTED: hypothetical protein XP_002342775 [Homo
           sapiens]
          Length = 834

 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 86/372 (23%), Positives = 129/372 (34%), Gaps = 56/372 (15%)

Query: 224 IVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPAL 283
           ++   S+ P     +P  PT      T     + P   P++           S    PA 
Sbjct: 248 LIPAPSMVPATDTKAP--PTLQAETTTKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAA 305

Query: 284 SQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPED 343
           S     FK      I   P   +++   P     P V   A S SSL +  +    T + 
Sbjct: 306 SSASPMFKP-----IFTAPPKSEKEGPTP---PGPSVSATAPSSSSLPTTTSTTAPTFQP 357

Query: 344 PFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDA 403
            FSS  M  P +V  P +P F+   T +       P  T LA     V      + + D+
Sbjct: 358 VFSS--MGPPASVPLP-APFFKQTTTPATAPTTTAPLFTGLASATSAVAPITSASPSTDS 414

Query: 404 ANK--------EIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQ 455
           A+K         ++++   T    ++ A+ P LF A      + A  +   +    +  +
Sbjct: 415 ASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQ----ASAASFTPAMGSIFQFGK 470

Query: 456 PQA-----SAAPLQPVLQPPPPTAISQPASPFQG--NAFLTSQPV--------------P 494
           P A     +       L    PTA S  A+ F G  +   TS P               P
Sbjct: 471 PPALPTTTTVTTFSQSLPTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTP 530

Query: 495 VGVVPALQPAFVPAQSYPVANGMPYPA--------PNVPVVGITPSQMVANVFGTAGHPQ 546
              +P    A  P  SYP AN  P PA        P      +TPS   +  FG +  P 
Sbjct: 531 TFNIPFGSSAKSPLPSYPGAN--PQPAFGAAEGQPPGAAKPALTPSFGSSFTFGNSAAPA 588

Query: 547 AAHPHQSPSLVR 558
           AA     PS+++
Sbjct: 589 AAPTPAPPSMIK 600


>gi|31317301 nitric oxide synthase 1 (neuronal) adaptor protein
           isoform 1 [Homo sapiens]
          Length = 506

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 65/269 (24%), Positives = 112/269 (41%), Gaps = 46/269 (17%)

Query: 28  DEEGVRTGKCSFPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAV 87
           +E+  + G C F  KY+G ++V           A++R++ E      F  K  KK  K  
Sbjct: 22  NEDAFQHGIC-FEAKYVGSLDVPRPNSRVEIVAAMRRIRYE------FKAKNIKKK-KVS 73

Query: 88  LWVSADGLRVVDEKTKDLIVDQTIE----------------KVSFCAPDRNFDRAFSYIC 131
           + VS DG++V+ +K K L++ Q  E                ++ + + D    + FSYI 
Sbjct: 74  IMVSVDGVKVILKKKKKLLLLQKKEWTWDESKMLVMQDPIYRIFYVSHDSQDLKIFSYIA 133

Query: 132 RDGTTRRWICHCFMAVKDT-GERLSHAVGCAFAAC----LERKQKR-------EKECGVT 179
           RDG +  + C+ F + K +   R+   VG AF  C    L+  Q+        E E    
Sbjct: 134 RDGASNIFRCNVFKSKKKSQAMRIVRTVGQAFEVCHKLSLQHTQQNADGQEDGESERNSN 193

Query: 180 ATFDASRTTFTREGSFRVTTAT-EQAEREEIM-----KQMQDAKKAETDKIVVGSSVAPG 233
           ++ D  R      G+ R +TAT E+ + + +        + +  +  TD   VG      
Sbjct: 194 SSGDPGRQL---TGAERASTATAEETDIDAVEVPLPGNDVLEFSRGVTDLDAVGKE-GGS 249

Query: 234 NTAPSPSSPTSPTSDATTSLEMNNPHAIP 262
           +T    S P  P   A+  + + +  + P
Sbjct: 250 HTGSKVSHPQEPMLTASPRMLLPSSSSKP 278


>gi|26051278 nuclear pore membrane protein 121 [Homo sapiens]
          Length = 984

 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 82/368 (22%), Positives = 126/368 (34%), Gaps = 48/368 (13%)

Query: 224 IVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPAL 283
           ++   S+ P     +P  PT     AT     + P   P++           S    PA 
Sbjct: 399 LIPAPSMVPATDTKAP--PTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAA 456

Query: 284 SQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPED 343
           S     FK      I   P   +++   P     P V   A S SSL +  +    T + 
Sbjct: 457 SSAPPMFKP-----IFTAPPKSEKEGPTP---PGPSVTATAPSSSSLPTTTSTTAPTFQP 508

Query: 344 PFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDA 403
            FSS  M  P +V  P +P F+   T +       P  T LA     V      + + D+
Sbjct: 509 VFSS--MGPPASVPLP-APFFKQTTTPATAPTTTAPLFTGLASATSAVAPITSASPSTDS 565

Query: 404 ANK--------EIAATCSGTEWGQSSGAASPGLFQAGHRRTPS----------------- 438
           A+K         ++++   T    ++ A+ P LF A      S                 
Sbjct: 566 ASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPPAL 625

Query: 439 EADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVV 498
                +   S+S+    P A+++            A S PA+  Q     ++   P   +
Sbjct: 626 PTTTTVTTFSQSLHTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTPTFNI 685

Query: 499 PALQPAFVPAQSYPVANGMPYPA--------PNVPVVGITPSQMVANVFGTAGHPQAAHP 550
           P    A  P  SYP AN  P PA        P      + PS   +  FG +  P AA  
Sbjct: 686 PFGSSAKSPLPSYPGAN--PQPAFGAAEGQPPGAAKPALAPSFGSSFTFGNSAAPAAAPT 743

Query: 551 HQSPSLVR 558
              PS+++
Sbjct: 744 PAPPSMIK 751



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 75/365 (20%), Positives = 123/365 (33%), Gaps = 54/365 (14%)

Query: 232 PGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFK 291
           P  TA +PSS + PT+ +TT              AP  Q     S  G PA     +PF 
Sbjct: 483 PSVTATAPSSSSLPTTTSTT--------------APTFQPVF--SSMGPPASVPLPAPFF 526

Query: 292 RQLSLRINELPSTMQRKTDF--------PIKNAVPEVEGEAESISSLCSQITNAFSTPED 343
           +Q +       +T    T          PI +A P  +  ++          ++ S    
Sbjct: 527 KQTTTPATAPTTTAPLFTGLASATSAVAPITSASPSTDSASKPAFGFGINSVSSSSVSTT 586

Query: 344 PFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAH-APD 402
             ++   ++P    APQ+          +     KP      P    V   +   H A  
Sbjct: 587 TSTATAASQPFLFGAPQASAASFTPAMGSIFQFGKPP---ALPTTTTVTTFSQSLHTAVP 643

Query: 403 AANKEIAATCSGTEWGQSSGAASPGLFQA-----GHRRTPSEADRWLEEVSKSVRAQQPQ 457
            A    AA  SG  +G +   ++P           +  TP+  +      +KS     P 
Sbjct: 644 TATSSSAADFSG--FGSTLATSAPATSSQPTLTFSNTSTPT-FNIPFGSSAKSPLPSYPG 700

Query: 458 ASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQ---------PVPVGVVPALQPAFVPA 508
           A+  P     +  PP A     +P  G++F             P P  ++  + PA+VP 
Sbjct: 701 ANPQPAFGAAEGQPPGAAKPALAPSFGSSFTFGNSAAPAAAPTPAPPSMIKVV-PAYVPT 759

Query: 509 QSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEAS 568
             +P+  G  + A  +        +  A+ FG     Q A    +       T   + A+
Sbjct: 760 PIHPIFGGATHSAFGL--------KATASAFGAPASSQPAFGGSTAVFFGAATSSGFGAT 811

Query: 569 SATTS 573
           + T S
Sbjct: 812 TQTAS 816


>gi|19111150 angiomotin isoform 2 [Homo sapiens]
          Length = 675

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 93/396 (23%), Positives = 144/396 (36%), Gaps = 59/396 (14%)

Query: 154 LSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQM 213
           +SH+   ++   LE + ++E+E        A++     EG  + T   +  E++ ++K +
Sbjct: 302 ISHSPNTSYDTALEARIQKEEE----EILMANKRCLDMEGRIK-TLHAQIIEKDAMIKVL 356

Query: 214 QDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLAR 273
           Q   + E  K    S + P  +  S S+  S                          L+ 
Sbjct: 357 QQRSRKEPSKTEQLSCMRPAKSLMSISNAGSGL------------------------LSH 392

Query: 274 QGSFRGFPALSQKMSPFKRQLSLRI---NELPSTMQRKTDFPIKNAVPEVEGEAESISSL 330
             +  G P + +K      + SL I    +  +     T  P+  + P +   +++ S  
Sbjct: 393 SSTLTGSPIMEEKRDDKSWKGSLGILLGGDYRAEYVPSTPSPVPPSTPLLSAHSKTGSRD 452

Query: 331 CSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHT---ALAPV 387
           CS  T   +      + AP++ P  V A          T +A    A    T   A APV
Sbjct: 453 CSTQTERGTESNKTAAVAPISVPAPVAAA--------ATAAAITATAATITTTMVAAAPV 504

Query: 388 AMPVRETNPWAHAPDAANKEI-AATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEE 446
           A+        A AP  A     AA  S    GQ   AAS     A     PS A     +
Sbjct: 505 AVAAAAAPAAAAAPSPATAAATAAAVSPAAAGQIPAAASVASAAAV---APSAAAAAAVQ 561

Query: 447 VSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFV 506
           V+       P A A    P L P P  A +Q ++P Q  A  TS P  V   PA  P   
Sbjct: 562 VA-------PAAPAPVPAPALVPVPAPAAAQASAPAQTQA-PTSAPA-VAPTPAPTPTPA 612

Query: 507 PAQSYPVANGMPYPAP---NVPVVGITPSQMVANVF 539
            AQ+   A+    P P   ++P +   P +    VF
Sbjct: 613 VAQAEVPASPATGPGPHRLSIPSLTCNPDKTDGPVF 648


>gi|166064029 angiomotin isoform 1 [Homo sapiens]
          Length = 1084

 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 93/396 (23%), Positives = 144/396 (36%), Gaps = 59/396 (14%)

Query: 154  LSHAVGCAFAACLERKQKREKECGVTATFDASRTTFTREGSFRVTTATEQAEREEIMKQM 213
            +SH+   ++   LE + ++E+E        A++     EG  + T   +  E++ ++K +
Sbjct: 711  ISHSPNTSYDTALEARIQKEEE----EILMANKRCLDMEGRIK-TLHAQIIEKDAMIKVL 765

Query: 214  QDAKKAETDKIVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLAR 273
            Q   + E  K    S + P  +  S S+  S                          L+ 
Sbjct: 766  QQRSRKEPSKTEQLSCMRPAKSLMSISNAGSGL------------------------LSH 801

Query: 274  QGSFRGFPALSQKMSPFKRQLSLRI---NELPSTMQRKTDFPIKNAVPEVEGEAESISSL 330
              +  G P + +K      + SL I    +  +     T  P+  + P +   +++ S  
Sbjct: 802  SSTLTGSPIMEEKRDDKSWKGSLGILLGGDYRAEYVPSTPSPVPPSTPLLSAHSKTGSRD 861

Query: 331  CSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHT---ALAPV 387
            CS  T   +      + AP++ P  V A          T +A    A    T   A APV
Sbjct: 862  CSTQTERGTESNKTAAVAPISVPAPVAAA--------ATAAAITATAATITTTMVAAAPV 913

Query: 388  AMPVRETNPWAHAPDAANKEI-AATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEE 446
            A+        A AP  A     AA  S    GQ   AAS     A     PS A     +
Sbjct: 914  AVAAAAAPAAAAAPSPATAAATAAAVSPAAAGQIPAAASVASAAAV---APSAAAAAAVQ 970

Query: 447  VSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFV 506
            V+       P A A    P L P P  A +Q ++P Q  A  TS P  V   PA  P   
Sbjct: 971  VA-------PAAPAPVPAPALVPVPAPAAAQASAPAQTQA-PTSAPA-VAPTPAPTPTPA 1021

Query: 507  PAQSYPVANGMPYPAP---NVPVVGITPSQMVANVF 539
             AQ+   A+    P P   ++P +   P +    VF
Sbjct: 1022 VAQAEVPASPATGPGPHRLSIPSLTCNPDKTDGPVF 1057


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 48.1 bits (113), Expect = 2e-05
 Identities = 89/382 (23%), Positives = 129/382 (33%), Gaps = 63/382 (16%)

Query: 238  SPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLR 297
            SPS   S ++     L +++P      H P        S    P  S   SP    +S+ 
Sbjct: 1380 SPSPEVSASAPGAAPLTISSP-----LHVPSSLPGPASSPMPIPNSSPLASPVSSTVSVP 1434

Query: 298  INE-----LPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTK 352
            ++      +P+T+      P+   +P           + + +T + S P    S  P   
Sbjct: 1435 LSSSLPISVPTTLPAPASAPL--TIP-----------ISAPLTVSASGPALLTSVTPPLA 1481

Query: 353  PVTVVAPQSPTFQANGTDSAFHVLA-----KPAHTALAPVAMPVRETNPWAHAPDAANKE 407
            PV   AP  P+   +G   +   L       P+ ++      P+      +H P   N  
Sbjct: 1482 PVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAPTSSHVP-GLNST 1540

Query: 408  IAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVL 467
            +A  CS      +S  ASP  F +     P++A       S S      QA A PL P+ 
Sbjct: 1541 VAPACSPV-LVPASALASP--FPSAPNPAPAQASLLAPASSAS------QALATPLAPMA 1591

Query: 468  QPPPPTAISQPASPFQGNAFLTSQPVPVGV-------VPALQPAFVPAQSYPVANGMPYP 520
             P        PA P      L   P    V       VP + P+  P  S   A+ +P P
Sbjct: 1592 APQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTSLASASPVPAP 1651

Query: 521  AP-----------NVPVVGITPS----QMVANVFGTAGHPQAAHPHQSPSLVR---QQTF 562
             P             PV    PS    Q +A     A     + P Q+ SL     Q  F
Sbjct: 1652 TPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGPF 1711

Query: 563  PHYEASSATTSPFFKPPAQHLN 584
            P    S    S     PAQ L+
Sbjct: 1712 PTQTLSLTPASSLVPTPAQTLS 1733



 Score = 33.1 bits (74), Expect = 0.82
 Identities = 46/187 (24%), Positives = 73/187 (39%), Gaps = 19/187 (10%)

Query: 374  HVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQSSGAASP------G 427
            H++++PAH AL     P     P +  P +      A  +G     ++    P      G
Sbjct: 1249 HLISQPAHVALIQAVAPTPGPTPVSVLPSSTPSTTPAP-TGLSLPLAANQVPPTMVNNTG 1307

Query: 428  LFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAF 487
            + +   R+ P +    L  V     A +P +S  P   VL P P     +  +P  G A 
Sbjct: 1308 VVKIVVRQAPRDG---LTPVPPLAPAPRPPSSGLP--AVLNPRPTLTPGRLPTPTLGTA- 1361

Query: 488  LTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTAGHPQA 547
                P P  V P L+   V + S  V+   P  A   P+   +P  + +++ G A  P  
Sbjct: 1362 RAPMPTPTLVRPLLK--LVHSPSPEVSASAPGAA---PLTISSPLHVPSSLPGPASSPMP 1416

Query: 548  AHPHQSP 554
              P+ SP
Sbjct: 1417 I-PNSSP 1422


>gi|148491082 disabled homolog 2 [Homo sapiens]
          Length = 770

 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 32/116 (27%), Positives = 61/116 (52%), Gaps = 12/116 (10%)

Query: 39  FPVKYLGHVEVDESRGMHICEDAVKRLKAERKFFKGFFGKTGKKAVKAVLWVSADGLRVV 98
           +  K +G  +V ++RG  + +D++ +LK      +      G+   +  + +S  G++++
Sbjct: 50  YKAKLIGIDDVPDARGDKMSQDSMMKLKGMAAAGRS----QGQHKQRIWVNISLSGIKII 105

Query: 99  DEKTKDLIVDQTIEKVSFCAPDRNFDRAFSYIC-RDGTTRRWICHCFMAVKDTGER 153
           DEKT  +  +  + K+SF A D   +RAF Y+C  +G       H F A+K TG++
Sbjct: 106 DEKTGVIEHEHPVNKISFIARDVTDNRAFGYVCGGEGQ------HQFFAIK-TGQQ 154


>gi|150378545 POM121 membrane glycoprotein (rat)-like [Homo sapiens]
          Length = 987

 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 90/382 (23%), Positives = 131/382 (34%), Gaps = 67/382 (17%)

Query: 224 IVVGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPAL 283
           ++   S+ P     +P  PT     AT     + P   P++           S    PA 
Sbjct: 399 LIPAPSMVPATDTKAP--PTLQAETATKPQATSAPSPAPKQSFLFGTQNTSPSSPAAPAA 456

Query: 284 SQKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPED 343
           S     FK      I   P   +++   P     P V   A S SSL +  +    T + 
Sbjct: 457 SSASPMFKP-----IFTAPPKSEKEGPTP---PGPSVTATAPSSSSLPTTTSTTAPTFQP 508

Query: 344 PFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDA 403
            FSS  M  P +V  P +P F+   T +       P  T LA     V      + + D+
Sbjct: 509 VFSS--MGPPASVPLP-APFFKQTTTPATAPTTTAPLFTGLASATSAVAPITSASPSTDS 565

Query: 404 ANK--------EIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQ 455
           A+K         ++++   T    ++ A+ P LF A      + A  +   +    +  +
Sbjct: 566 ASKPAFGFGINSVSSSSVSTTTSTATAASQPFLFGAPQ----ASAASFTPAMGSIFQFGK 621

Query: 456 PQA-----SAAPLQPVLQPPPPTAISQPASPFQG--NAFLTSQPV--------------P 494
           P A     +       L    PTA S  A+ F G  +   TS P               P
Sbjct: 622 PPALPTTTTVTTFSQSLPTAVPTATSSSAADFSGFGSTLATSAPATSSQPTLTFSNTSTP 681

Query: 495 VGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGTA--GHPQAAHPHQ 552
              +P    A  P  SYP AN  P PA                 FG A    P AA P  
Sbjct: 682 TFNIPFGSSAKSPLPSYPGAN--PQPA-----------------FGAAEGQPPGAAKPAL 722

Query: 553 SPSLVRQQTFPHYEASSATTSP 574
           +PS     TF +  A +  T+P
Sbjct: 723 TPSFGSSFTFGNSAAPAPATAP 744


>gi|21327715 transcription elongation regulator 1 isoform 1 [Homo
           sapiens]
          Length = 1098

 Score = 46.2 bits (108), Expect = 9e-05
 Identities = 36/107 (33%), Positives = 46/107 (42%), Gaps = 13/107 (12%)

Query: 435 RTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVP 494
           +TPS A   +   + +V    P  +A P+Q V QP P T    PA P        S P P
Sbjct: 304 QTPSSA---VSVATPTVSVSTPAPTATPVQTVPQPHPQTL--PPAVPH-------SVPQP 351

Query: 495 VGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGT 541
              +PA  P  VP    P+  GMP P P V ++ I     V  V  T
Sbjct: 352 TTAIPAFPPVMVPPFRVPLP-GMPIPLPGVAMMQIVSCPYVKTVATT 397



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 26/91 (28%), Positives = 37/91 (40%), Gaps = 17/91 (18%)

Query: 453 AQQPQASAAPLQPVLQPPPPTAISQ-----PASPFQGNAF---LTSQPVPVGVVPALQPA 504
           A  P A      P+++PPPP  + +     P  PF    F   +   P P G+ P + P 
Sbjct: 33  APPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPP 92

Query: 505 FV--------PAQSYPVANGMPYPAPNVPVV 527
            +        P  S P   GM +P P +P V
Sbjct: 93  HLQRPPFMPPPMSSMPPPPGMMFP-PGMPPV 122


>gi|91208420 bassoon protein [Homo sapiens]
          Length = 3926

 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 45/180 (25%), Positives = 66/180 (36%), Gaps = 11/180 (6%)

Query: 456  PQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVAN 515
            P    A  QP  QPP P   +    P Q        P   G      PAF P  SYP   
Sbjct: 3045 PSGPTAFQQPRFQPPAPQYSAGSGGPTQNGFPAHQAPTYPGPSTYPAPAFPPGASYPAEP 3104

Query: 516  GMPYP---APNVPVVGITPSQMV-ANVFGTAGHPQA--AHPHQSPSLVRQQTFP-HYEAS 568
            G+P      P     G TP     + +F      +A    P Q+     +Q  P +YE  
Sbjct: 3105 GLPNQQAFRPTGHYAGQTPMPTTQSTLFPVPADSRAPLQKPRQTSLADLEQKVPTNYEVI 3164

Query: 569  SATTSPFFKPPAQ-HLNGSAAFNGVDDGRLASADR---HTEVPTGTCPVDPFEAQWAALE 624
            ++   P    P++   +G A  +G + G++    R      V     P  P ++ + +LE
Sbjct: 3165 ASPVVPMSSAPSETSYSGPAVSSGYEQGKVPEVPRAGDRGSVSQSPAPTYPSDSHYTSLE 3224



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 63/221 (28%), Positives = 76/221 (34%), Gaps = 46/221 (20%)

Query: 344  PFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDA 403
            PFS  P T   T VAP        G    +   A PA +  +P   P    + + H+P  
Sbjct: 1373 PFSQGPGTPATTAVAPCPA-----GLPRGYMTPASPAGSERSP--SPSSTAHSYGHSPTT 1425

Query: 404  ANKEIAATCSGTEWGQSSGAASPGLFQAGH--RRTPSEADRWLEEVSKSVRAQQPQASAA 461
            AN       S TE       A  GL  AG   R  P  A        +  RA    AS++
Sbjct: 1426 ANYG-----SQTE---DLPQAPSGLAAAGRAAREKPLSASDGEGGTPQPSRAYSYFASSS 1477

Query: 462  P-LQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYP 520
            P L P      PT       P     F T  P P            PA   P + G P  
Sbjct: 1478 PPLSPSSPSESPTFSPGKMGPRATAEFSTQTPSPA-----------PASDMPRSPGAP-- 1524

Query: 521  APNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQT 561
                     TPS MVA   GT    Q  H   +P LV Q++
Sbjct: 1525 ---------TPSPMVAQ--GT----QTPHRPSTPRLVWQES 1550


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 94/464 (20%), Positives = 150/464 (32%), Gaps = 78/464 (16%)

Query: 179 TATFDASRTTFTREG-SFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAP 237
           T+T    +TT  +E  S   T+A + A   +++ +     KAET      ++  P  T P
Sbjct: 162 TSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK--PTPKAET------TTKGPALTTP 213

Query: 238 SPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLR 297
              +PT+P   A+T+ +   P  I                +  P   ++ +P   + +  
Sbjct: 214 KEPTPTTPKEPASTTPKEPTPTTI----------------KSAPTTPKEPAPTTTKSAPT 257

Query: 298 INELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVV 357
             + P+    K   P     P+      +     +   +A +TP++P  + P     T  
Sbjct: 258 TPKEPAPTTTKEPAP---TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 314

Query: 358 APQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAAN--KEIAATCSGT 415
              +PT     T +      +PA T   P     +E  P A    A    KE A T    
Sbjct: 315 KEPAPTTPKEPTPTT---PKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE 371

Query: 416 EWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAI 475
               ++   SP         TP E                P  + +      +P P T  
Sbjct: 372 PAPTTTKEPSP--------TTPKEP--------------APTTTKSAPTTTKEPAPTTTK 409

Query: 476 SQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMV 535
           S P +P + +   T +P P            P +  P     P P         TP +  
Sbjct: 410 SAPTTPKEPSPTTTKEPAPT----------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 459

Query: 536 ANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDG 595
                T   P    P +      ++T P        T+P      + L  +         
Sbjct: 460 PT---TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTP------EKLAPTTPEKPAPTT 510

Query: 596 RLASADRHTEVPTGTCPVDPF-EAQWAALENKSKQRTNPSPTNP 638
               A    E PT T P +P      AA  N  K+   P+PT P
Sbjct: 511 PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE---PAPTTP 551



 Score = 36.6 bits (83), Expect = 0.075
 Identities = 78/365 (21%), Positives = 123/365 (33%), Gaps = 47/365 (12%)

Query: 232 PGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSP-F 290
           P  T P   +PT+P   A T+L+   P   P++ AP ++LA   +       S K +P  
Sbjct: 631 PAPTTPKEPAPTTPKGTAPTTLKEPAP-TTPKKPAP-KELAPTTTKGPTSTTSDKPAPTT 688

Query: 291 KRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPED--PFSSA 348
            ++ +    + P+    K   P     P       S  +   + T    +P++  P  SA
Sbjct: 689 PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 748

Query: 349 PMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEI 408
             T      +P+ P      T +A     KP  T  A      R+         AA K  
Sbjct: 749 EPTPKALENSPKEPGVPTTKTPAA----TKPEMTTTAKDKTTERDLRTTPETTTAAPKMT 804

Query: 409 AATCSGTEWGQSS---------------------------GAASPGLFQAGHRRTPSEAD 441
             T + TE    S                              +P +       T +E  
Sbjct: 805 KETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIM 864

Query: 442 RWLEEVSK-SVRAQQPQASA-APLQPVLQPPPPTAISQPASPFQGNAFLTSQPVP---VG 496
              EE +K   RA   +A+   P +P   P  PT+  +P +  +     T+ P P     
Sbjct: 865 NKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTS 923

Query: 497 VVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITP-SQMVANVFGTAGH----PQAAHPH 551
            +P L P    A++       P   PN  +V + P S+      G   H    P    P 
Sbjct: 924 TMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPE 983

Query: 552 QSPSL 556
            +P +
Sbjct: 984 VTPDM 988


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 94/464 (20%), Positives = 150/464 (32%), Gaps = 78/464 (16%)

Query: 179 TATFDASRTTFTREG-SFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAP 237
           T+T    +TT  +E  S   T+A + A   +++ +     KAET      ++  P  T P
Sbjct: 203 TSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK--PTPKAET------TTKGPALTTP 254

Query: 238 SPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLR 297
              +PT+P   A+T+ +   P  I                +  P   ++ +P   + +  
Sbjct: 255 KEPTPTTPKEPASTTPKEPTPTTI----------------KSAPTTPKEPAPTTTKSAPT 298

Query: 298 INELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVV 357
             + P+    K   P     P+      +     +   +A +TP++P  + P     T  
Sbjct: 299 TPKEPAPTTTKEPAP---TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 355

Query: 358 APQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAAN--KEIAATCSGT 415
              +PT     T +      +PA T   P     +E  P A    A    KE A T    
Sbjct: 356 KEPAPTTPKEPTPTT---PKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE 412

Query: 416 EWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAI 475
               ++   SP         TP E                P  + +      +P P T  
Sbjct: 413 PAPTTTKEPSP--------TTPKEP--------------APTTTKSAPTTTKEPAPTTTK 450

Query: 476 SQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMV 535
           S P +P + +   T +P P            P +  P     P P         TP +  
Sbjct: 451 SAPTTPKEPSPTTTKEPAPT----------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 500

Query: 536 ANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDG 595
                T   P    P +      ++T P        T+P      + L  +         
Sbjct: 501 PT---TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTP------EKLAPTTPEKPAPTT 551

Query: 596 RLASADRHTEVPTGTCPVDPF-EAQWAALENKSKQRTNPSPTNP 638
               A    E PT T P +P      AA  N  K+   P+PT P
Sbjct: 552 PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE---PAPTTP 592



 Score = 36.6 bits (83), Expect = 0.075
 Identities = 78/365 (21%), Positives = 123/365 (33%), Gaps = 47/365 (12%)

Query: 232  PGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSP-F 290
            P  T P   +PT+P   A T+L+   P   P++ AP ++LA   +       S K +P  
Sbjct: 672  PAPTTPKEPAPTTPKGTAPTTLKEPAP-TTPKKPAP-KELAPTTTKGPTSTTSDKPAPTT 729

Query: 291  KRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPED--PFSSA 348
             ++ +    + P+    K   P     P       S  +   + T    +P++  P  SA
Sbjct: 730  PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 789

Query: 349  PMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEI 408
              T      +P+ P      T +A     KP  T  A      R+         AA K  
Sbjct: 790  EPTPKALENSPKEPGVPTTKTPAA----TKPEMTTTAKDKTTERDLRTTPETTTAAPKMT 845

Query: 409  AATCSGTEWGQSS---------------------------GAASPGLFQAGHRRTPSEAD 441
              T + TE    S                              +P +       T +E  
Sbjct: 846  KETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIM 905

Query: 442  RWLEEVSK-SVRAQQPQASA-APLQPVLQPPPPTAISQPASPFQGNAFLTSQPVP---VG 496
               EE +K   RA   +A+   P +P   P  PT+  +P +  +     T+ P P     
Sbjct: 906  NKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTS 964

Query: 497  VVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITP-SQMVANVFGTAGH----PQAAHPH 551
             +P L P    A++       P   PN  +V + P S+      G   H    P    P 
Sbjct: 965  TMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPE 1024

Query: 552  QSPSL 556
             +P +
Sbjct: 1025 VTPDM 1029


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 94/464 (20%), Positives = 150/464 (32%), Gaps = 78/464 (16%)

Query: 179 TATFDASRTTFTREG-SFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAP 237
           T+T    +TT  +E  S   T+A + A   +++ +     KAET      ++  P  T P
Sbjct: 255 TSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK--PTPKAET------TTKGPALTTP 306

Query: 238 SPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLR 297
              +PT+P   A+T+ +   P  I                +  P   ++ +P   + +  
Sbjct: 307 KEPTPTTPKEPASTTPKEPTPTTI----------------KSAPTTPKEPAPTTTKSAPT 350

Query: 298 INELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVV 357
             + P+    K   P     P+      +     +   +A +TP++P  + P     T  
Sbjct: 351 TPKEPAPTTTKEPAP---TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 407

Query: 358 APQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAAN--KEIAATCSGT 415
              +PT     T +      +PA T   P     +E  P A    A    KE A T    
Sbjct: 408 KEPAPTTPKEPTPTT---PKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE 464

Query: 416 EWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAI 475
               ++   SP         TP E                P  + +      +P P T  
Sbjct: 465 PAPTTTKEPSP--------TTPKEP--------------APTTTKSAPTTTKEPAPTTTK 502

Query: 476 SQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMV 535
           S P +P + +   T +P P            P +  P     P P         TP +  
Sbjct: 503 SAPTTPKEPSPTTTKEPAPT----------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 552

Query: 536 ANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDG 595
                T   P    P +      ++T P        T+P      + L  +         
Sbjct: 553 PT---TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTP------EKLAPTTPEKPAPTT 603

Query: 596 RLASADRHTEVPTGTCPVDPF-EAQWAALENKSKQRTNPSPTNP 638
               A    E PT T P +P      AA  N  K+   P+PT P
Sbjct: 604 PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE---PAPTTP 644



 Score = 36.6 bits (83), Expect = 0.075
 Identities = 78/365 (21%), Positives = 123/365 (33%), Gaps = 47/365 (12%)

Query: 232  PGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSP-F 290
            P  T P   +PT+P   A T+L+   P   P++ AP ++LA   +       S K +P  
Sbjct: 724  PAPTTPKEPAPTTPKGTAPTTLKEPAP-TTPKKPAP-KELAPTTTKGPTSTTSDKPAPTT 781

Query: 291  KRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPED--PFSSA 348
             ++ +    + P+    K   P     P       S  +   + T    +P++  P  SA
Sbjct: 782  PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 841

Query: 349  PMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEI 408
              T      +P+ P      T +A     KP  T  A      R+         AA K  
Sbjct: 842  EPTPKALENSPKEPGVPTTKTPAA----TKPEMTTTAKDKTTERDLRTTPETTTAAPKMT 897

Query: 409  AATCSGTEWGQSS---------------------------GAASPGLFQAGHRRTPSEAD 441
              T + TE    S                              +P +       T +E  
Sbjct: 898  KETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIM 957

Query: 442  RWLEEVSK-SVRAQQPQASA-APLQPVLQPPPPTAISQPASPFQGNAFLTSQPVP---VG 496
               EE +K   RA   +A+   P +P   P  PT+  +P +  +     T+ P P     
Sbjct: 958  NKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTS 1016

Query: 497  VVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITP-SQMVANVFGTAGH----PQAAHPH 551
             +P L P    A++       P   PN  +V + P S+      G   H    P    P 
Sbjct: 1017 TMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPE 1076

Query: 552  QSPSL 556
             +P +
Sbjct: 1077 VTPDM 1081


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 94/464 (20%), Positives = 150/464 (32%), Gaps = 78/464 (16%)

Query: 179 TATFDASRTTFTREG-SFRVTTATEQAEREEIMKQMQDAKKAETDKIVVGSSVAPGNTAP 237
           T+T    +TT  +E  S   T+A + A   +++ +     KAET      ++  P  T P
Sbjct: 296 TSTDGKEKTTSAKETQSIEKTSAKDLAPTSKVLAK--PTPKAET------TTKGPALTTP 347

Query: 238 SPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPFKRQLSLR 297
              +PT+P   A+T+ +   P  I                +  P   ++ +P   + +  
Sbjct: 348 KEPTPTTPKEPASTTPKEPTPTTI----------------KSAPTTPKEPAPTTTKSAPT 391

Query: 298 INELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVV 357
             + P+    K   P     P+      +     +   +A +TP++P  + P     T  
Sbjct: 392 TPKEPAPTTTKEPAP---TTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTP 448

Query: 358 APQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAAN--KEIAATCSGT 415
              +PT     T +      +PA T   P     +E  P A    A    KE A T    
Sbjct: 449 KEPAPTTPKEPTPTT---PKEPAPTTKEPAPTTPKEPAPTAPKKPAPTTPKEPAPTTPKE 505

Query: 416 EWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAI 475
               ++   SP         TP E                P  + +      +P P T  
Sbjct: 506 PAPTTTKEPSP--------TTPKEP--------------APTTTKSAPTTTKEPAPTTTK 543

Query: 476 SQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMV 535
           S P +P + +   T +P P            P +  P     P P         TP +  
Sbjct: 544 SAPTTPKEPSPTTTKEPAPT----------TPKEPAPTTPKKPAPTTPKEPAPTTPKEPA 593

Query: 536 ANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFFKPPAQHLNGSAAFNGVDDG 595
                T   P    P +      ++T P        T+P      + L  +         
Sbjct: 594 PT---TTKKPAPTTPKEPAPTTPKETAPTTPKKLTPTTP------EKLAPTTPEKPAPTT 644

Query: 596 RLASADRHTEVPTGTCPVDPF-EAQWAALENKSKQRTNPSPTNP 638
               A    E PT T P +P      AA  N  K+   P+PT P
Sbjct: 645 PEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKE---PAPTTP 685



 Score = 36.6 bits (83), Expect = 0.075
 Identities = 78/365 (21%), Positives = 123/365 (33%), Gaps = 47/365 (12%)

Query: 232  PGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSP-F 290
            P  T P   +PT+P   A T+L+   P   P++ AP ++LA   +       S K +P  
Sbjct: 765  PAPTTPKEPAPTTPKGTAPTTLKEPAP-TTPKKPAP-KELAPTTTKGPTSTTSDKPAPTT 822

Query: 291  KRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPED--PFSSA 348
             ++ +    + P+    K   P     P       S  +   + T    +P++  P  SA
Sbjct: 823  PKETAPTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA 882

Query: 349  PMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANKEI 408
              T      +P+ P      T +A     KP  T  A      R+         AA K  
Sbjct: 883  EPTPKALENSPKEPGVPTTKTPAA----TKPEMTTTAKDKTTERDLRTTPETTTAAPKMT 938

Query: 409  AATCSGTEWGQSS---------------------------GAASPGLFQAGHRRTPSEAD 441
              T + TE    S                              +P +       T +E  
Sbjct: 939  KETATTTEKTTESKITATTTQVTSTTTQDTTPFKITTLKTTTLAPKVTTTKKTITTTEIM 998

Query: 442  RWLEEVSK-SVRAQQPQASA-APLQPVLQPPPPTAISQPASPFQGNAFLTSQPVP---VG 496
               EE +K   RA   +A+   P +P   P  PT+  +P +  +     T+ P P     
Sbjct: 999  NKPEETAKPKDRATNSKATTPKPQKPTKAPKKPTSTKKPKTMPRVRKPKTT-PTPRKMTS 1057

Query: 497  VVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITP-SQMVANVFGTAGH----PQAAHPH 551
             +P L P    A++       P   PN  +V + P S+      G   H    P    P 
Sbjct: 1058 TMPELNPTSRIAEAMLQTTTRPNQTPNSKLVEVNPKSEDAGGAEGETPHMLLRPHVFMPE 1117

Query: 552  QSPSL 556
             +P +
Sbjct: 1118 VTPDM 1122


>gi|239757130 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 855

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 88/345 (25%), Positives = 118/345 (34%), Gaps = 67/345 (19%)

Query: 226 VGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQG-SFRGFPALS 284
           V S+     T PSP++   P++     L+     ++     P+   AR G S RG P   
Sbjct: 209 VSSASEHSTTEPSPAARRRPSAGG--GLQRPASRSLSSSATPLSSPARSGPSARGTPRAP 266

Query: 285 QKMSPFKRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAFSTPEDP 344
              S  K +       L +    +   P K+A P +                       P
Sbjct: 267 AHPSQPKPK------GLQALRPPQVTPPRKDAAPAL----------------------GP 298

Query: 345 FSSAPMTKPVTVVAPQS---PTFQANGTDSAFHV-LAKPAHTAL-APVAMPVRETNPWAH 399
            SS+P+  P    A QS   PT  A    S+    LA P   A  +P A P  +T P   
Sbjct: 299 LSSSPLATPSPSAALQSQAPPTLPATPHSSSLTCQLATPLPLAPPSPSAPPSLQTLP--- 355

Query: 400 APDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQAS 459
           +P A     A T  G          SP L QA H   PS            +    PQA 
Sbjct: 356 SPPATPPSQATTSLG----------SPTL-QATHSFLPSPP-------LSPLATPPPQAP 397

Query: 460 AAPLQPVLQPPP---------PTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQS 510
            A   P LQ PP         P A   P +P      L   P      P +Q  F P  S
Sbjct: 398 PALALPPLQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPAS 457

Query: 511 YPVANGMPYPAPNVPVVGITPSQMVANVFGTAG-HPQAAHPHQSP 554
            PV+     P+   P +   P Q+  +   +    P A  P Q+P
Sbjct: 458 PPVSPSATPPSQAPPSLAAPPLQVPPSPPASPPMSPSATPPPQAP 502



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 89/376 (23%), Positives = 128/376 (34%), Gaps = 39/376 (10%)

Query: 233 GNTAPSPSSPTSPTSDATTSLE--MNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPF 290
           G  A  P   T P  DA  +L    ++P A P   A ++  A   +    P  S      
Sbjct: 276 GLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSAALQSQAPP-TLPATPHSSSLTCQL 334

Query: 291 KRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNAF--STPEDPFSSA 348
              L L     PS        P   A P  +    S+ S   Q T++F  S P  P ++ 
Sbjct: 335 ATPLPLAPPS-PSAPPSLQTLPSPPATPPSQATT-SLGSPTLQATHSFLPSPPLSPLATP 392

Query: 349 PMTKPVTVVAP--QSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAANK 406
           P   P  +  P  Q+P              + PA   L+P+A P  +  P A A      
Sbjct: 393 PPQAPPALALPPLQAPP-------------SPPASPPLSPLATPSPQA-PNALAVHLLQA 438

Query: 407 EIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPV 466
             +   S       S  ASP +  +     PS+A   L      V    P   A+P    
Sbjct: 439 PFSPPPSPPVQAPFSPPASPPVSPSA--TPPSQAPPSLAAPPLQV---PPSPPASPPMSP 493

Query: 467 LQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPY-PAPNVP 525
              PPP A    A+P    A    Q  P    P LQ    P  S+P     P+ P+ ++P
Sbjct: 494 SATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPASFP--GQAPFSPSASLP 551

Query: 526 VVGI-TPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSATTSPFF-------K 577
           +  + TP      V           P  SP+L   +  P     ++ + P          
Sbjct: 552 MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRRPPTPGPDTSVSGPRLTLALAPGP 611

Query: 578 PPAQHLNGSAAFNGVD 593
           PP    + S+  +G D
Sbjct: 612 PPPPSRSPSSTLSGPD 627


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 98/401 (24%), Positives = 136/401 (33%), Gaps = 57/401 (14%)

Query: 231 APGNTAPS--PSSPTSPTSDATTSLE----MNNPHAI--PRRHAPIEQLARQG----SFR 278
           +P  T PS  P S T+P   A  SL+    +  PH++  P   AP   LA       +  
Sbjct: 359 SPPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSL 418

Query: 279 GFPALSQK-----MSPFKRQLSLRINELPST-------MQRKTDFPIKNAVPEVEGEAES 326
           G P L        MSP + Q SL     P++       +Q     P   + P     + +
Sbjct: 419 GSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPA--SPPLQTSLSPA 476

Query: 327 ISSLCSQITN---------AFSTPEDPFSSA---PMTKPVTVVAPQSPTFQANGTDSAFH 374
           +S L S +T          A  +P+ P SS    P+    ++  P   T  A+ T     
Sbjct: 477 VSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLE 536

Query: 375 VLAK----PAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQSSGA----ASP 426
            L      P  TA AP+  P  ET P              T    E   S       A P
Sbjct: 537 NLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPP 596

Query: 427 GLFQAGHRRTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPP-----PTAISQPASP 481
            L     +  PS     L  ++       P  +  PLQ    PP      P A   P +P
Sbjct: 597 ALASPPLQGLPSPP---LSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQAP 653

Query: 482 FQGNAFLTSQPVPVGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITPSQMVANVFGT 541
                 L   P      P +Q  F P  S PV+     P+   P +   P Q+  +   +
Sbjct: 654 NALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPPSPPAS 713

Query: 542 AG-HPQAAHPHQSPSLVRQQTF--PHYEASSATTSPFFKPP 579
               P A  P Q+P  +       P    +S   SP   PP
Sbjct: 714 PPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPP 754



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 83/391 (21%), Positives = 140/391 (35%), Gaps = 75/391 (19%)

Query: 226 VGSSVAPGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQG-SFRGFPALS 284
           V S+     T PSP++   P++     L+     ++     P+   AR G S RG P   
Sbjct: 209 VSSASEHSTTEPSPAARRRPSAGG--GLQRPASRSLSSSATPLSSPARSGPSARGTPRAP 266

Query: 285 Q----------------KMSPFKRQLSLRINEL---------PSTMQRKTDFPIKNAVPE 319
                            +++P ++  +  +  L         PS  + +   P  NA   
Sbjct: 267 AHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATP 326

Query: 320 VEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKP 379
           +         L + +  A  +P  P S   +  P     P +P  QA  + +   + A P
Sbjct: 327 LPATLPPSPPLATPLPLAPPSPSAPPSLQTLPSP-----PATPPSQAPPSMTTPPMQAPP 381

Query: 380 AHTALAPVAMPVRETNPWAHAPDA--ANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTP 437
           +   + P+ +P   T+P   AP +  A   + AT   T  G  +  A+        R+T 
Sbjct: 382 SLQTIPPIQVPHSLTSPSLQAPPSPLALSSLQAT---TSLGSPTLQATHSFLTMSPRQTQ 438

Query: 438 SEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGV 497
           +           S+ +    AS  P  P LQ P    +S PASP          P+   +
Sbjct: 439 A-----------SLTSPSRPASTPPDSPPLQAP----LSLPASP----------PLQTSL 473

Query: 498 VPALQPAFVPAQSYPV--ANGMPYPAPNVPVVGI------TPSQMVANVFGTAGHPQAAH 549
            PA+ P   P   +P+   + +   +P  P+  +      T S +      T        
Sbjct: 474 SPAVSPLSSPLTIHPLQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTP 533

Query: 550 PHQS-PSLVRQQTFPHYEASSATTSPFFKPP 579
           P ++ PSL      P   AS+  T+P  + P
Sbjct: 534 PLENLPSLAPP---PLQTASAPLTTPHLETP 561



 Score = 34.7 bits (78), Expect = 0.28
 Identities = 73/303 (24%), Positives = 107/303 (35%), Gaps = 34/303 (11%)

Query: 231 APGNTAPSPSSPTSPTSDATTSLEMNNPHAIPRRHAPIEQLARQGSFRGFPALSQKMSPF 290
           AP      PS  T+P  +  +S+    P A P   +P          +G P  S  +SP 
Sbjct: 565 APCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASP--------PLQGLP--SPPLSPL 614

Query: 291 -----KRQLSLRINELPSTMQRKTDFPIKNAVPEVEGEAESISSLCSQITNA-FSTPEDP 344
                +    L +  L +        P+    P      ++ ++L   +  A FS P  P
Sbjct: 615 ATPPPQAPPXLALPPLQAPPSPPASPPLS---PLATPSPQAPNALAVHLLQAPFSPPPSP 671

Query: 345 FSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLAKPAHTALAPVAMPVRETNPWAHAPDAA 404
              AP + P +     S T  +    S   + A P     +P A P    +P A  P  A
Sbjct: 672 PVQAPFSPPASPPVSPSATPPSQAPPS---LAAPPLQVPPSPPASP--PMSPSATPPPQA 726

Query: 405 NKEIAATCSGTEWGQSSGAASPGLFQAGHR--RTPSEADRWLEEVSKSVRAQQPQASAA- 461
              +AA          S  ASP +  +     R P        +V  S  A  P +  A 
Sbjct: 727 PPPLAAPPLQVP---PSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAK 783

Query: 462 -PLQ--PVLQPPPPTAISQPASPFQGNA-FLTSQPVPVGVVPALQPAFVPAQSYPVANGM 517
            P Q  P L  PP  A+  P + F G A F  S  +P+  +    P   P  + P+    
Sbjct: 784 PPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVP 843

Query: 518 PYP 520
           P P
Sbjct: 844 PSP 846



 Score = 34.3 bits (77), Expect = 0.37
 Identities = 56/253 (22%), Positives = 91/253 (35%), Gaps = 12/253 (4%)

Query: 393 ETNPWAHAPDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTPSEADRWLEEVSKSVR 452
           E +P A    +A   +    S +    ++  +SP       R TP       +   K ++
Sbjct: 219 EPSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQ 278

Query: 453 AQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGVVPALQPAFVPAQSYP 512
           A +P     P +       P + S  A+P          P P      L PA +P  S P
Sbjct: 279 ALRPPQVTPPRKDAAPALGPLSSSPLATPSPSGTKARPVPPPDNAATPL-PATLPP-SPP 336

Query: 513 VANGMPY--PAPNVPVVGITPSQMVANVFGTAGHPQAAHPHQSPSLVRQQTFPHYEASSA 570
           +A  +P   P+P+ P    T     A     A       P Q+P  +  QT P  +   +
Sbjct: 337 LATPLPLAPPSPSAPPSLQTLPSPPATPPSQAPPSMTTPPMQAPPSL--QTIPPIQVPHS 394

Query: 571 TTSPFFKPPAQHLNGSAAFNGVDDGRLASADRHTEVPTGTCPVDPFEAQWAALENKSKQR 630
            TSP  + P   L  S+       G       H+ +      + P + Q A+L + S+  
Sbjct: 395 LTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFL-----TMSPRQTQ-ASLTSPSRPA 448

Query: 631 TNPSPTNPFSSDL 643
           + P  + P  + L
Sbjct: 449 STPPDSPPLQAPL 461



 Score = 33.9 bits (76), Expect = 0.48
 Identities = 50/205 (24%), Positives = 73/205 (35%), Gaps = 24/205 (11%)

Query: 318 PEVEGEAESISSLCSQITNAFSTPEDPFSSAPMTKPVTVVAPQSPTFQANGTDSAFHVLA 377
           P  EG  +S+SS      +  ST E   S A   +P      Q P   +    S+   L+
Sbjct: 200 PPTEGPRKSVSS-----ASEHSTTEP--SPAARRRPSAGGGLQRPA--SRSLSSSATPLS 250

Query: 378 KPAHTALAPVAMPVRETNPWAHAPDAANKEIAATCSGTEWGQSSGAASPGLFQAGHRRTP 437
            PA +  +    P    +P    P       A         +   A + G   +    TP
Sbjct: 251 SPARSGPSARGTPRAPAHPSQPKPKGLQ---ALRPPQVTPPRKDAAPALGPLSSSPLATP 307

Query: 438 SEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVPVGV 497
           S +       +K+     P  +A PL   L P PP A   P +P   +A  + Q +P   
Sbjct: 308 SPSG------TKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLP--- 358

Query: 498 VPALQPAFVPAQSYPVANGMPYPAP 522
                PA  P+Q+ P     P  AP
Sbjct: 359 ---SPPATPPSQAPPSMTTPPMQAP 380


>gi|91208418 transcription elongation regulator 1 isoform 2 [Homo
           sapiens]
          Length = 1077

 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 34/97 (35%), Positives = 44/97 (45%), Gaps = 14/97 (14%)

Query: 435 RTPSEADRWLEEVSKSVRAQQPQASAAPLQPVLQPPPPTAISQPASPFQGNAFLTSQPVP 494
           +TPS A   +   + +V    P  +A P+Q V QP P T    PA P        S P P
Sbjct: 304 QTPSSA---VSVATPTVSVSTPAPTATPVQTVPQPHPQTL--PPAVPH-------SVPQP 351

Query: 495 VGVVPALQPAFVPAQSYPVANGMPYPAPNVPVVGITP 531
              +PA  P  VP    P+  GMP P P V + G+ P
Sbjct: 352 TTAIPAFPPVMVPPFRVPLP-GMPIPLPGV-LPGMAP 386



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 26/91 (28%), Positives = 37/91 (40%), Gaps = 17/91 (18%)

Query: 453 AQQPQASAAPLQPVLQPPPPTAISQ-----PASPFQGNAF---LTSQPVPVGVVPALQPA 504
           A  P A      P+++PPPP  + +     P  PF    F   +   P P G+ P + P 
Sbjct: 33  APPPNAVMRGPPPLMRPPPPFGMMRGPPPPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPP 92

Query: 505 FV--------PAQSYPVANGMPYPAPNVPVV 527
            +        P  S P   GM +P P +P V
Sbjct: 93  HLQRPPFMPPPMSSMPPPPGMMFP-PGMPPV 122


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.315    0.128    0.385 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 27,923,418
Number of Sequences: 37866
Number of extensions: 1477886
Number of successful extensions: 10417
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 48
Number of HSP's successfully gapped in prelim test: 522
Number of HSP's that attempted gapping in prelim test: 8444
Number of HSP's gapped (non-prelim): 1984
length of query: 651
length of database: 18,247,518
effective HSP length: 109
effective length of query: 542
effective length of database: 14,120,124
effective search space: 7653107208
effective search space used: 7653107208
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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