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Search of human proteins with 52630447
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
(552 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52630447 palmitoylated membrane protein 2 [Homo sapiens] 1100 0.0
gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens] 779 0.0
gi|186700629 calcium/calmodulin-dependent serine protein kinase ... 417 e-116
gi|186700627 calcium/calmodulin-dependent serine protein kinase ... 409 e-114
gi|186972120 calcium/calmodulin-dependent serine protein kinase ... 401 e-111
gi|111154074 palmitoylated membrane protein 7 [Homo sapiens] 353 2e-97
gi|4505237 palmitoylated membrane protein 1 [Homo sapiens] 348 6e-96
gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens] 340 2e-93
gi|21536464 palmitoylated membrane protein 3 [Homo sapiens] 296 3e-80
gi|218156338 chapsyn-110 isoform 1 [Homo sapiens] 178 1e-44
gi|91199538 chapsyn-110 isoform 2 [Homo sapiens] 178 1e-44
gi|218156340 chapsyn-110 isoform 3 [Homo sapiens] 172 5e-43
gi|119943106 synapse-associated protein 102 isoform a [Homo sapi... 171 2e-42
gi|119943108 synapse-associated protein 102 isoform b [Homo sapi... 166 4e-41
gi|218156270 chapsyn-110 isoform 4 [Homo sapiens] 166 5e-41
gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens] 165 9e-41
gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens] 162 1e-39
gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens] 152 8e-37
gi|4557529 post-synaptic density protein 95 isoform 1 [Homo sapi... 148 1e-35
gi|192447426 post-synaptic density protein 95 isoform 2 [Homo sa... 148 1e-35
gi|226874833 guanylate kinase 1 isoform b [Homo sapiens] 109 7e-24
gi|226874831 guanylate kinase 1 isoform a [Homo sapiens] 109 7e-24
gi|4504221 guanylate kinase 1 isoform b [Homo sapiens] 109 7e-24
gi|10092691 tight junction protein 3 [Homo sapiens] 59 1e-08
gi|42518065 tight junction protein 2 (zona occludens 2) isoform ... 53 8e-07
gi|42518070 tight junction protein 2 (zona occludens 2) isoform ... 53 8e-07
gi|21389483 leucine-rich repeats and guanylate kinase domain con... 52 2e-06
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 50 5e-06
gi|155969695 membrane-associated guanylate kinase-related 3 iso... 50 5e-06
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 49 2e-05
>gi|52630447 palmitoylated membrane protein 2 [Homo sapiens]
Length = 552
Score = 1100 bits (2844), Expect = 0.0
Identities = 552/552 (100%), Positives = 552/552 (100%)
Query: 1 MPVAATNSETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKL 60
MPVAATNSETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKL
Sbjct: 1 MPVAATNSETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKL 60
Query: 61 EAVRDNNLELVQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYETPPP 120
EAVRDNNLELVQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYETPPP
Sbjct: 61 EAVRDNNLELVQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYETPPP 120
Query: 121 SPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLH 180
SPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLH
Sbjct: 121 SPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLH 180
Query: 181 VGDIIKEVNGQPVGSDPRALQELLRNASGSVILKILPSYQEPHLPRQVFVKCHFDYDPAR 240
VGDIIKEVNGQPVGSDPRALQELLRNASGSVILKILPSYQEPHLPRQVFVKCHFDYDPAR
Sbjct: 181 VGDIIKEVNGQPVGSDPRALQELLRNASGSVILKILPSYQEPHLPRQVFVKCHFDYDPAR 240
Query: 241 DSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSAGLIPSQLLEEKRKAFVKRDL 300
DSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSAGLIPSQLLEEKRKAFVKRDL
Sbjct: 241 DSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSAGLIPSQLLEEKRKAFVKRDL 300
Query: 301 ELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQG 360
ELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQG
Sbjct: 301 ELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQG 360
Query: 361 VGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHG 420
VGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHG
Sbjct: 361 VGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHG 420
Query: 421 EYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMN 480
EYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMN
Sbjct: 421 EYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMN 480
Query: 481 RAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLR 540
RAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLR
Sbjct: 481 RAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLR 540
Query: 541 TEPQWVPVSWVY 552
TEPQWVPVSWVY
Sbjct: 541 TEPQWVPVSWVY 552
>gi|21361598 membrane protein, palmitoylated 6 [Homo sapiens]
Length = 540
Score = 779 bits (2011), Expect = 0.0
Identities = 377/543 (69%), Positives = 464/543 (85%), Gaps = 5/543 (0%)
Query: 12 MQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKLEAVRDNNLELV 71
MQQVL+NL LPS+TGA E+DLIFL+GIME+PIV+SLAKAHERLE++KLEAV DNNLELV
Sbjct: 1 MQQVLENLTELPSSTGAEEIDLIFLKGIMENPIVKSLAKAHERLEDSKLEAVSDNNLELV 60
Query: 72 QEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYETPPPSPGLD-PTFSN 130
EIL D+ + AEL IL+EPHFQSLLE HD VASK Y++PP SP ++ + +N
Sbjct: 61 NEILEDITPLINVDENVAELVGILKEPHFQSLLEAHDIVASKCYDSPPSSPEMNNSSINN 120
Query: 131 QPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNG 190
Q +P DA+R++GI K AGE LGVTFRVE +LVIARILHGGM+ +QGLLHVGDIIKEVNG
Sbjct: 121 QLLPVDAIRILGIHKRAGEPLGVTFRVENNDLVIARILHGGMIDRQGLLHVGDIIKEVNG 180
Query: 191 QPVGSDPRALQELLRNASGSVILKILPSYQEPHLPRQVFVKCHFDYDPARDSLIPCKEAG 250
VG++P+ LQELL+N SGSV LKILPSY++ P+QVFVKCHFDY+P D+LIPCKEAG
Sbjct: 181 HEVGNNPKELQELLKNISGSVTLKILPSYRDTITPQQVFVKCHFDYNPYNDNLIPCKEAG 240
Query: 251 LRFNAGDLLQIVNQDDANWWQACHV-EGGSAGLIPSQLLEEKRKAFVKRDLELTPNSGTL 309
L+F+ G++LQIVN++D NWWQA HV EGGSAGLIPSQ LEEKRKAFV+RD + NSG
Sbjct: 241 LKFSKGEILQIVNREDPNWWQASHVKEGGSAGLIPSQFLEEKRKAFVRRDWD---NSGPF 297
Query: 310 CGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNK 369
CG++S KKKK+MMYLTT+NAEFDRHE+ IYEEVA+MPPF+RKTLVLIGAQGVGRRSLKN+
Sbjct: 298 CGTISSKKKKKMMYLTTRNAEFDRHEIQIYEEVAKMPPFQRKTLVLIGAQGVGRRSLKNR 357
Query: 370 LIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGT 429
I+ +P R+GTTVP+TSR+P++ E++GQ Y FVSR EMEAD++AG+YLEHGEYEGNLYGT
Sbjct: 358 FIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGKYLEHGEYEGNLYGT 417
Query: 430 RIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGIS 489
+IDSI VV G+ C+LDVNPQA+KVLRT+EF+PYVVFI AP+ ETLRAM++A +++GI+
Sbjct: 418 KIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETLRAMHKAVVDAGIT 477
Query: 490 TKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVS 549
TK LT++DL++TV+ES+RIQR Y HYFDL ++N NL++ F +LQTA+EKLR EPQWVP+S
Sbjct: 478 TKLLTDSDLKKTVDESARIQRAYNHYFDLIIINDNLDKAFEKLQTAIEKLRMEPQWVPIS 537
Query: 550 WVY 552
WVY
Sbjct: 538 WVY 540
>gi|186700629 calcium/calmodulin-dependent serine protein kinase
isoform 3 [Homo sapiens]
Length = 897
Score = 417 bits (1072), Expect = e-116
Identities = 238/579 (41%), Positives = 347/579 (59%), Gaps = 52/579 (8%)
Query: 8 SETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKLEAVRDNN 67
S A+ QVLD+L + + T +E DL FL + + + +L ++++ +R+
Sbjct: 337 SSGAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPP 396
Query: 68 LELVQ---EILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYE------TP 118
+ VQ E+L +++ E + A EL IL +PHF +LL+THD VA + Y TP
Sbjct: 397 SDAVQRAKEVLEEISCYPENND-AKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTP 455
Query: 119 PPSP----GLDPTFSNQPVPPD---AVRMVGIRKTAGEHLGVTFRV-EGGELVIARILHG 170
PP+ G P +N + + VR+V +K E +G+T ++ E ++ARI+HG
Sbjct: 456 PPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHG 515
Query: 171 GMVAQQGLLHVGDIIKEVNGQPVGSDP-RALQELLRNASGSVILKILPSYQEPH-----L 224
GM+ +QG LHVGD I+E+NG V + LQ++LR GS+ KI+PSY+ L
Sbjct: 516 GMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDL 575
Query: 225 P-------RQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQAC--HV 275
P RQ++V+ F+YDPA+D LIPCKEAG+RF GD++QI+++DD NWWQ +
Sbjct: 576 PSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENS 635
Query: 276 EGGSAGLIPSQLLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMM--YLTTKNAEFDR 333
+ G+AGLIPS L+E R A + +E T + GKKKK+ YL NA FD+
Sbjct: 636 KNGTAGLIPSPELQEWRVACIA--MEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQ 693
Query: 334 HELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSE 393
+L+ YEEV ++P F+RKTLVL+GA GVGRR +KN LI PDR+ +P+T+R PK E
Sbjct: 694 LDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDE 753
Query: 394 REGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAV 453
G+ Y FVS +M D+ YLE+G +E +YGT++++IR + G + +LDV PQA+
Sbjct: 754 ENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQAL 813
Query: 454 KVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYG 513
KVLRTAEF P+VVFI AP + G++ + L+R +ES +QR Y
Sbjct: 814 KVLRTAEFAPFVVFIAAP-----------TITPGLN----EDESLQRLQKESDILQRTYA 858
Query: 514 HYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 552
HYFDL ++N+ ++ T R L+ A+E + T PQWVPVSWVY
Sbjct: 859 HYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 897
>gi|186700627 calcium/calmodulin-dependent serine protein kinase
isoform 2 [Homo sapiens]
Length = 898
Score = 409 bits (1051), Expect = e-114
Identities = 236/579 (40%), Positives = 345/579 (59%), Gaps = 57/579 (9%)
Query: 8 SETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKLEAVRDNN 67
+E A+ QVLD+L + + T +E DL FL + + + +L ++++ +R+
Sbjct: 343 AERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPP 402
Query: 68 LELVQ---EILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYE------TP 118
+ VQ E+L +++ E + A EL IL +PHF +LL+THD VA + Y TP
Sbjct: 403 SDAVQRAKEVLEEISCYPENND-AKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTP 461
Query: 119 PPSP----GLDPTFSNQPVPPD---AVRMVGIRKTAGEHLGVTFRV-EGGELVIARILHG 170
PP+ G P +N + + VR+V +K E +G+T ++ E ++ARI+HG
Sbjct: 462 PPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHG 521
Query: 171 GMVAQQGLLHVGDIIKEVNGQPVGSDP-RALQELLRNASGSVILKILPSYQEPH-----L 224
GM+ +QG LHVGD I+E+NG V + LQ++LR GS+ KI+PSY+ L
Sbjct: 522 GMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCEDL 581
Query: 225 P-------RQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQAC--HV 275
P RQ++V+ F+YDPA+D LIPCKEAG+RF GD++QI+++DD NWWQ +
Sbjct: 582 PSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENS 641
Query: 276 EGGSAGLIPSQLLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMM--YLTTKNAEFDR 333
+ G+AGLIPS L+E R A + +E T + GKKKK+ YL NA+
Sbjct: 642 KNGTAGLIPSPELQEWRVACIA--MEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAD--- 696
Query: 334 HELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSE 393
L+ YEEV ++P F+RKTLVL+GA GVGRR +KN LI PDR+ +P+T+R PK E
Sbjct: 697 --LVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDE 754
Query: 394 REGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAV 453
G+ Y FVS +M D+ YLE+G +E +YGT++++IR + G + +LDV PQA+
Sbjct: 755 ENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQAL 814
Query: 454 KVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYG 513
KVLRTAEF P+VVFI AP + G++ + L+R +ES +QR Y
Sbjct: 815 KVLRTAEFAPFVVFIAAP-----------TITPGLN----EDESLQRLQKESDILQRTYA 859
Query: 514 HYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 552
HYFDL ++N+ ++ T R L+ A+E + T PQWVPVSWVY
Sbjct: 860 HYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 898
>gi|186972120 calcium/calmodulin-dependent serine protein kinase
isoform 1 [Homo sapiens]
Length = 921
Score = 401 bits (1030), Expect = e-111
Identities = 238/602 (39%), Positives = 346/602 (57%), Gaps = 80/602 (13%)
Query: 8 SETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERLEETKLEAVRDNN 67
+E A+ QVLD+L + + T +E DL FL + + + +L ++++ +R+
Sbjct: 343 AERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPP 402
Query: 68 LELVQ---EILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYE------TP 118
+ VQ E+L +++ E + A EL IL +PHF +LL+THD VA + Y TP
Sbjct: 403 SDAVQRAKEVLEEISCYPENND-AKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTP 461
Query: 119 PPSP----GLDPTFSNQPVPPD---AVRMVGIRKTAGEHLGVTFRV-EGGELVIARILHG 170
PP+ G P +N + + VR+V +K E +G+T ++ E ++ARI+HG
Sbjct: 462 PPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHG 521
Query: 171 GMVAQQGLLHVGDIIKEVNGQPVGSDP-RALQELLRNASGSVILKILPSY---------- 219
GM+ +QG LHVGD I+E+NG V + LQ++LR GS+ KI+PSY
Sbjct: 522 GMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERD 581
Query: 220 ------QEP------------HLP-------RQVFVKCHFDYDPARDSLIPCKEAGLRFN 254
Q P LP RQ++V+ F+YDPA+D LIPCKEAG+RF
Sbjct: 582 SPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFR 641
Query: 255 AGDLLQIVNQDDANWWQAC--HVEGGSAGLIPSQLLEEKRKAFVKRDLELTPNSGTLCGS 312
GD++QI+++DD NWWQ + + G+AGLIPS L+E R A + +E T +
Sbjct: 642 VGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIA--MEKTKQEQQASCT 699
Query: 313 LSGKKKKRMM--YLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKL 370
GKKKK+ YL NA+ L+ YEEV ++P F+RKTLVL+GA GVGRR +KN L
Sbjct: 700 WFGKKKKQYKDKYLAKHNAD-----LVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTL 754
Query: 371 IMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTR 430
I PDR+ +P+T+R PK E G+ Y FVS +M D+ YLE+G +E +YGT+
Sbjct: 755 ITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTK 814
Query: 431 IDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGIST 490
+++IR + G + +LDV PQA+KVLRTAEF P+VVFI AP + G++
Sbjct: 815 LETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAP-----------TITPGLN- 862
Query: 491 KQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSW 550
+ L+R +ES +QR Y HYFDL ++N+ ++ T R L+ A+E + T PQWVPVSW
Sbjct: 863 ---EDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSW 919
Query: 551 VY 552
VY
Sbjct: 920 VY 921
>gi|111154074 palmitoylated membrane protein 7 [Homo sapiens]
Length = 576
Score = 353 bits (906), Expect = 2e-97
Identities = 214/585 (36%), Positives = 327/585 (55%), Gaps = 43/585 (7%)
Query: 1 MPVAATNS--ETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERL--- 55
MP +T S +T + ++L L + ++ DL FL + + SL K HE+L
Sbjct: 1 MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYY 60
Query: 56 EETKLEAVRDNNLELVQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTY 115
E+ + L ++ +L + +S EL +L +P+ ++LL HD+VA K Y
Sbjct: 61 EKQSPVPILHGAAALADDLAEELQN-KPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNY 119
Query: 116 ETPPPSPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEG--GELVIARILHGGMV 173
+ P L P + D+V+++ + K E LG T + + G +++ARI+ GG
Sbjct: 120 D-----PVLPPMPEDIDDEEDSVKIIRLVKNR-EPLGATIKKDEQTGAIIVARIMRGGAA 173
Query: 174 AQQGLLHVGDIIKEVNGQPVGSD-PRALQELLRNASGSVILKILPSYQE--PHLPRQVFV 230
+ GL+HVGD ++EVNG PV P + ++L + G++ KI+P +E P ++F+
Sbjct: 174 DRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFI 233
Query: 231 KCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGS--AGLIPSQLL 288
K FDY+P D IPCKEAGL F GD+LQI++QDDA WWQA H + AGLIPS+
Sbjct: 234 KALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHF 293
Query: 289 EEKRKAFVKRDLELTP-------NSG---TLCGSLSGKKKKRMMYLTTKNAEFDRHELLI 338
+E+R A + ++ + P +SG + S KK + MY K+ ++D ++
Sbjct: 294 QERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPT 353
Query: 339 YEEVARMPPFRRKT------LVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDS 392
YEEV P+RR+T +VL+G GVG LK KL++ D YG TVP+T+R +
Sbjct: 354 YEEVT---PYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQ 410
Query: 393 EREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQA 452
E +G Y F+S+ E DV+ +++E+GEY+ N YGT IDS+R V+A KVC+LDV P
Sbjct: 411 ESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHT 470
Query: 453 VKVLRTAEFVPYVVFIEAPDFETLRAMNR-----AALESGISTKQLTEADLRRTVEESSR 507
VK LRT EF PYV+FI+ P E LR + ++ + + K TE D + ++ +
Sbjct: 471 VKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQI 530
Query: 508 IQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 552
++ YGH FD ++N +L F EL+T +KL TE WVPVSW++
Sbjct: 531 MESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWLH 575
>gi|4505237 palmitoylated membrane protein 1 [Homo sapiens]
Length = 466
Score = 348 bits (894), Expect = 6e-96
Identities = 189/468 (40%), Positives = 282/468 (60%), Gaps = 30/468 (6%)
Query: 91 LAHILQE-PHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKTAGE 149
L H+LQ+ +++ ++V Y P+PG Q V VR++ K E
Sbjct: 23 LEHLLQKRSRPEAVSHPLNTVTEDMYTNGSPAPGSPAQVKGQEVRK--VRLIQFEKVTEE 80
Query: 150 HLGVTFRV-EGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGSDP-RALQELLRNA 207
+G+T ++ E +ARILHGGM+ +QG LHVGD I E+NG V + LQ+ ++
Sbjct: 81 PMGITLKLNEKQSCTVARILHGGMIHRQGSLHVGDEILEINGTNVTNHSVDQLQKAMKET 140
Query: 208 SGSVILKILPSYQEPHLPRQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDA 267
G + LK++P+ Q Q+F++ FDYDP +D+LIPCKEAGL+F GD++QI+N+DD+
Sbjct: 141 KGMISLKVIPNQQSRLPALQMFMRAQFDYDPKKDNLIPCKEAGLKFATGDIIQIINKDDS 200
Query: 268 NWWQACHVEGGS---AGLIPSQLLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMMYL 324
NWWQ VEG S AGLIPS L+E R A + + P+ C KKK + YL
Sbjct: 201 NWWQG-RVEGSSKESAGLIPSPELQEWRVASMAQS---APSEAPSCSPFGKKKKYKDKYL 256
Query: 325 TTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPY 384
++ FD+ +++ YEEV R+P F+RKTLVLIGA GVGR +KN L+ +P+++ VPY
Sbjct: 257 AKHSSIFDQLDVVSYEEVVRLPAFKRKTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPY 316
Query: 385 TSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVC 444
T+R P+ SE +G+ Y F+S EM ++ A +LE G Y+GN++GT+ +++ + K+
Sbjct: 317 TTRPPRKSEEDGKEYHFISTEEMTRNISANEFLEFGSYQGNMFGTKFETVHQIHKQNKIA 376
Query: 445 VLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEE 504
+LD+ PQ +K++RTAE P++VFI D T TEA L++ ++
Sbjct: 377 ILDIEPQTLKIVRTAELSPFIVFIAPTDQGT-----------------QTEA-LQQLQKD 418
Query: 505 SSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWVY 552
S I+ Y HYFDL LVN+ ++ T ++LQ A ++ + PQWVPVSWVY
Sbjct: 419 SEAIRSQYAHYFDLSLVNNGVDETLKKLQEAFDQACSSPQWVPVSWVY 466
>gi|38570142 membrane protein, palmitoylated 5 [Homo sapiens]
Length = 675
Score = 340 bits (873), Expect = 2e-93
Identities = 186/495 (37%), Positives = 291/495 (58%), Gaps = 27/495 (5%)
Query: 71 VQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSN 130
VQ +L+ + H Q TA +L PH Q+LL HD VA + + P +
Sbjct: 193 VQTVLKPVHHKEGQELTA-----LLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIG 247
Query: 131 QPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNG 190
Q + V++V I K LG T R E ++I+RI+ GG + GLLH GD + E+NG
Sbjct: 248 Q-YGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEING 306
Query: 191 QPV-GSDPRALQELLRNASGSVILKILPSYQEPHLPRQ---VFVKCHFDYDPARDSLIPC 246
+ G D + +LL + G++ ++PS Q P + + VK HFDYDP+ D +PC
Sbjct: 307 IEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPC 366
Query: 247 KEAGLRFNAGDLLQIVNQDDANWWQACHVEGGS-----AGLIPSQLLEEKRKAF---VKR 298
+E GL F GD+L +++Q+D NWWQA + EG AGL+P + +++R+A ++
Sbjct: 367 RELGLSFQKGDILHVISQEDPNWWQA-YREGDEDNQPLAGLVPGKSFQQQREAMKQTIEE 425
Query: 299 DLELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVA--RMPPFRRKTLVLI 356
D E + C + KK+K+++Y KN ++D E+L YEE++ P R++ ++LI
Sbjct: 426 DKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILI 485
Query: 357 GAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRY 416
G Q G+ L+ +L+ + DR+ + VP+T+R +D E G+ Y FVSR EAD+ AG++
Sbjct: 486 GPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKF 545
Query: 417 LEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETL 476
+EHGE+E NLYGT IDS+R V+ +GK+C+L + Q++K LR ++ PY++FI P E L
Sbjct: 546 IEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERL 605
Query: 477 RAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAM 536
RA+ A E K +LR +E++ +++ GHYFD +VNS+L++ ++EL +
Sbjct: 606 RAL--LAKEG----KNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLI 659
Query: 537 EKLRTEPQWVPVSWV 551
KL TEPQWVP +W+
Sbjct: 660 NKLDTEPQWVPSTWL 674
>gi|21536464 palmitoylated membrane protein 3 [Homo sapiens]
Length = 585
Score = 296 bits (759), Expect = 3e-80
Identities = 203/603 (33%), Positives = 312/603 (51%), Gaps = 71/603 (11%)
Query: 1 MPVAATNSETAMQQVLDNLGSLPSATGAAELDLIFLRGIMESPIVRSLAKAHERL---EE 57
MPV + +S + + L L S + ++ FLR + + L K HE+L E
Sbjct: 1 MPVLSEDS--GLHETLALLTSQLRPDSNHKEEMGFLRDVFSEKSLSYLMKIHEKLRYYER 58
Query: 58 TKLEAVRDNNLELVQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYET 117
V + + L ++++ +L A S EL +L PH +++L HD+VA K ++
Sbjct: 59 QSPTPVLHSAVALAEDVMEEL-QAASVHSDERELLQLLSTPHLRAVLMVHDTVAQKNFDP 117
Query: 118 --PPPSPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVE--GGELVIARILHGGMV 173
PP +D F + V VR+V + E LG T R + G +V+ARI+ GG
Sbjct: 118 VLPPLPDNIDEDFDEESVK--IVRLVKNK----EPLGATIRRDEHSGAVVVARIMRGGAA 171
Query: 174 AQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRNASGSVILKILPSYQEPHLPRQ--VFV 230
+ GL+HVGD ++EVNG V P + ++L + GS+ LKI+P+ QE ++ VF+
Sbjct: 172 DRSGLVHVGDELREVNGIAVLHKRPDEISQILAQSQGSITLKIIPATQEEDRLKESKVFM 231
Query: 231 KCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGS--AGLIPSQLL 288
+ F Y+P D IPC+EAGL F +L++V+QDD WWQA V + AGLIPS+
Sbjct: 232 RALFHYNPREDRAIPCQEAGLPFQRRQVLEVVSQDDPTWWQAKRVGDTNLRAGLIPSKGF 291
Query: 289 EEKRKAFVKR-------------------DLELTPNSGTLCGS----------------L 313
+E+R ++ + D E G L G L
Sbjct: 292 QERRLSYRRAAGTLPSPQSLRKPPYDQPCDKETCDCEGYLKGHYVAGLRRSFRLGCRERL 351
Query: 314 SGKKKKRMMYLTTKNAEFDRHELLIYEEVAR---MPPFRRKTLVLIGAQGVGRRSLKNKL 370
G ++ +M ++ + ELL YEEVAR P R + +VLIG+ G LK K+
Sbjct: 352 GGSQEGKM------SSGAESPELLTYEEVARYQHQPGERPRLVVLIGSLGARLHELKQKV 405
Query: 371 IMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTR 430
+ +P +G VP+T+R K E+EG Y FVS+ EAD+ ++LEHGEY+ NLYGT
Sbjct: 406 VAENPQHFGVAVPHTTRPRKSHEKEGVEYHFVSKQAFEADLHHNKFLEHGEYKENLYGTS 465
Query: 431 IDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRA--MNRAALESGI 488
+++I+ V+A KVC++DV P+A+K LRT+EF PY++F++ E + M+ A +
Sbjct: 466 LEAIQAVMAKNKVCLVDVEPEALKQLRTSEFKPYIIFVKPAIQEKRKTPPMSPACED--- 522
Query: 489 STKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPV 548
T + + ++ I R YGH D LV +L+ + +L+ +EKL + WVPV
Sbjct: 523 -TAAPFDEQQQEMAASAAFIDRHYGHLVDAVLVKEDLQGAYSQLKVVLEKLSKDTHWVPV 581
Query: 549 SWV 551
SWV
Sbjct: 582 SWV 584
>gi|218156338 chapsyn-110 isoform 1 [Homo sapiens]
Length = 975
Score = 178 bits (452), Expect = 1e-44
Identities = 131/453 (28%), Positives = 215/453 (47%), Gaps = 74/453 (16%)
Query: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRN 206
G+ F + GGE + ++ IL GG G L GD I VNG + G+ L+
Sbjct: 535 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 594
Query: 207 ASGSVILKILPSYQ------------------------------EPHLPRQVFVKCHFDY 236
A +V I+ YQ + R ++V+ FDY
Sbjct: 595 AGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDY 652
Query: 237 DPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHV--EGGSA--GLIPSQLLEEKR 292
D ++DS +P + GL F GD+L ++N D WWQA V EG S G+IPS+ E++
Sbjct: 653 DKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERK 710
Query: 293 KAFVKRDLELTPNSGTLC--GSLSGKKKKRMMYLTT----KNAEFDRHE----------- 335
+ + ++ G + GS + K+KK ++ KN E E
Sbjct: 711 ERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDL 770
Query: 336 LLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSERE 395
+L YE V R + ++++G + + + LI PD++G+ VP+T+R +D E +
Sbjct: 771 ILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVD 827
Query: 396 GQGYSFV-SRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVK 454
G+ Y FV SR +ME D++ +++E G+Y NLYGT + S+R V GK C+LDV+ A+K
Sbjct: 828 GRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIK 887
Query: 455 VLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGH 514
L+ A+ P +FI+ E L MN K+LTE ++T + + ++++ +G
Sbjct: 888 RLQVAQLYPIAIFIKPRSLEPLMEMN----------KRLTEEQAKKTYDRAIKLEQEFGE 937
Query: 515 YFDLCLVNSNLERTFRELQTAMEKLRTEPQWVP 547
YF + LE + + + +E+ W+P
Sbjct: 938 YFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 970
>gi|91199538 chapsyn-110 isoform 2 [Homo sapiens]
Length = 870
Score = 178 bits (452), Expect = 1e-44
Identities = 131/453 (28%), Positives = 215/453 (47%), Gaps = 74/453 (16%)
Query: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRN 206
G+ F + GGE + ++ IL GG G L GD I VNG + G+ L+
Sbjct: 430 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELQRGDQILSVNGIDLRGASHEQAAAALKG 489
Query: 207 ASGSVILKILPSYQ------------------------------EPHLPRQVFVKCHFDY 236
A +V I+ YQ + R ++V+ FDY
Sbjct: 490 AGQTVT--IIAQYQPEDYARFEAKIHDLREQMMNHSMSSGSGSLRTNQKRSLYVRAMFDY 547
Query: 237 DPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHV--EGGSA--GLIPSQLLEEKR 292
D ++DS +P + GL F GD+L ++N D WWQA V EG S G+IPS+ E++
Sbjct: 548 DKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMGVIPSKRRVERK 605
Query: 293 KAFVKRDLELTPNSGTLC--GSLSGKKKKRMMYLTT----KNAEFDRHE----------- 335
+ + ++ G + GS + K+KK ++ KN E E
Sbjct: 606 ERARLKTVKFNAKPGVIDSKGSFNDKRKKSFIFSRKFPFYKNKEQSEQETSDPERGQEDL 665
Query: 336 LLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSERE 395
+L YE V R + ++++G + + + LI PD++G+ VP+T+R +D E +
Sbjct: 666 ILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVD 722
Query: 396 GQGYSFV-SRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVK 454
G+ Y FV SR +ME D++ +++E G+Y NLYGT + S+R V GK C+LDV+ A+K
Sbjct: 723 GRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIK 782
Query: 455 VLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGH 514
L+ A+ P +FI+ E L MN K+LTE ++T + + ++++ +G
Sbjct: 783 RLQVAQLYPIAIFIKPRSLEPLMEMN----------KRLTEEQAKKTYDRAIKLEQEFGE 832
Query: 515 YFDLCLVNSNLERTFRELQTAMEKLRTEPQWVP 547
YF + LE + + + +E+ W+P
Sbjct: 833 YFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 865
>gi|218156340 chapsyn-110 isoform 3 [Homo sapiens]
Length = 749
Score = 172 bits (437), Expect = 5e-43
Identities = 143/524 (27%), Positives = 230/524 (43%), Gaps = 86/524 (16%)
Query: 90 ELAHILQEPHFQSLLETHDSVASKTYETPPPSPG-LDPTFSNQPVPPD------------ 136
++ H P LL ++ PP SPG P + V D
Sbjct: 241 DITHSYSPPMENHLLSGNNGTLEYKTSLPPISPGRYSPIPKHMLVDDDYTSHSQHSTATR 300
Query: 137 --------AVRMVGIRKTAGEHLGVT---FRVEGGE----LVIARILHGGMVAQQGLLHV 181
AV + G + H G T F + GGE + ++ IL GG G L
Sbjct: 301 QPSMTLQRAVSLEGEPRKVVLHKGSTGLGFNIVGGEDGEGIFVSFILAGGPADLSGELQR 360
Query: 182 GDIIKEVNGQPV-GSDPRALQELLRNASGSVILKILPSYQ-------------------- 220
GD I VNG + G+ L+ A +V I+ YQ
Sbjct: 361 GDQILSVNGIDLRGASHEQAAAALKGAGQTVT--IIAQYQPEDYARFEAKIHDLREQMMN 418
Query: 221 ----------EPHLPRQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWW 270
+ R ++V+ FDYD ++DS +P + GL F GD+L ++N D WW
Sbjct: 419 HSMSSGSGSLRTNQKRSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWW 476
Query: 271 QACHV--EGGSA--GLIPSQLLEEKRKAFVKRDLELTPNSGTLC--GSLSGKKKKRMMYL 324
QA V EG S G+IPS+ E+++ + ++ G + G + G
Sbjct: 477 QARRVMLEGDSEEMGVIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGY--- 533
Query: 325 TTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPY 384
TK +L YE V R + ++++G + + + LI PD++G+ VP+
Sbjct: 534 GTKTLRGQEDLILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPH 590
Query: 385 TSRRPKDSEREGQGYSFV-SRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKV 443
T+R +D E +G+ Y FV SR +ME D++ +++E G+Y NLYGT + S+R V GK
Sbjct: 591 TTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKH 650
Query: 444 CVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVE 503
C+LDV+ A+K L+ A+ P +FI+ E L MN K+LTE ++T +
Sbjct: 651 CILDVSGNAIKRLQVAQLYPIAIFIKPRSLEPLMEMN----------KRLTEEQAKKTYD 700
Query: 504 ESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVP 547
+ ++++ +G YF + LE + + + +E+ W+P
Sbjct: 701 RAIKLEQEFGEYFTAIVQGDTLEDIYNQCKLVIEEQSGPFIWIP 744
>gi|119943106 synapse-associated protein 102 isoform a [Homo
sapiens]
Length = 817
Score = 171 bits (433), Expect = 2e-42
Identities = 126/440 (28%), Positives = 208/440 (47%), Gaps = 66/440 (15%)
Query: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNG---------QPVGSDPR 198
G+ F + GGE + ++ IL GG G L GD I VNG Q + R
Sbjct: 395 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKR 454
Query: 199 A------------------------LQELLRNASGSVILKILPSYQEPHLPRQVFVKCHF 234
A L+E + N+S S L + ++ R ++V+ F
Sbjct: 455 AGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK----RSLYVRALF 510
Query: 235 DYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQAC----HVEGGSAGLIPSQLLEE 290
DYD RDS +P + GL F+ GD+L ++N D WWQA H E G+IPS+ E
Sbjct: 511 DYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVE 568
Query: 291 KRKAFVKRDLELTPNSGTLCGS--LSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPF 348
K++ + ++ +G + + G Y KN + +L YE V R
Sbjct: 569 KKERARLKTVKFHARTGMIESNRDFPGLSDD---YYGAKNLKGQEDAILSYEPVTRQEIH 625
Query: 349 RRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFV-SRGEM 407
+ ++++G + + + LI P ++G+ VP+T+R +D+E +GQ Y FV SR +M
Sbjct: 626 YARPVIILGPM---KDRVNDDLISEFPHKFGSCVPHTTRPRRDNEVDGQDYHFVVSREQM 682
Query: 408 EADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVF 467
E D++ +++E G++ NLYGT I S+R V GK C+LDV+ A+K L+ A+ P +F
Sbjct: 683 EKDIQDNKFIEAGQFNDNLYGTSIQSVRAVAERGKHCILDVSGNAIKRLQQAQLYPIAIF 742
Query: 468 IEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLER 527
I+ E L MNR + T + +++ ++++ +G YF + +LE
Sbjct: 743 IKPKSIEALMEMNR----------RQTYEQANKIYDKAMKLEQEFGEYFTAIVQGDSLEE 792
Query: 528 TFRELQTAMEKLRTEPQWVP 547
+ +++ +E WVP
Sbjct: 793 IYNKIKQIIEDQSGHYIWVP 812
Score = 31.6 bits (70), Expect = 2.0
Identities = 26/94 (27%), Positives = 42/94 (44%), Gaps = 16/94 (17%)
Query: 134 PPDAVRMVGIRKTAGEHLGVTFRVEGG----------ELVIARILHGGMVAQQGLLHVGD 183
PP+ + V + K G+ F + GG + I +I+ GG + G L +GD
Sbjct: 220 PPETIMEVNLLKGPK---GLGFSIAGGIGNQHIPGDNSIYITKIIEGGAAQKDGRLQIGD 276
Query: 184 IIKEVNGQPVGSDPRALQEL--LRNASGSVILKI 215
+ VN + D R + + L+N S V LK+
Sbjct: 277 RLLAVNNTNL-QDVRHEEAVASLKNTSDMVYLKV 309
>gi|119943108 synapse-associated protein 102 isoform b [Homo
sapiens]
Length = 512
Score = 166 bits (421), Expect = 4e-41
Identities = 126/469 (26%), Positives = 214/469 (45%), Gaps = 92/469 (19%)
Query: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNG---------QPVGSDPR 198
G+ F + GGE + ++ IL GG G L GD I VNG Q + R
Sbjct: 58 GLGFNIVGGEDGEGIFVSFILAGGPADLSGELRRGDRILSVNGVNLRNATHEQAAAALKR 117
Query: 199 A------------------------LQELLRNASGSVILKILPSYQEPHLPRQVFVKCHF 234
A L+E + N+S S L + ++ R ++V+ F
Sbjct: 118 AGQSVTIVAQYRPEEYSRFESKIHDLREQMMNSSMSSGSGSLRTSEK----RSLYVRALF 173
Query: 235 DYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQAC----HVEGGSAGLIPSQLLEE 290
DYD RDS +P + GL F+ GD+L ++N D WWQA H E G+IPS+ E
Sbjct: 174 DYDRTRDSCLPSQ--GLSFSYGDILHVINASDDEWWQARLVTPHGESEQIGVIPSKKRVE 231
Query: 291 KRKAFVKRDLELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHE--------------- 335
K++ + ++ +G + + S K K++ + ++ F + +
Sbjct: 232 KKERARLKTVKFHARTGMIESNRSIKTKRKKSFRLSRKFPFYKSKENMAQESSIQEQGVT 291
Query: 336 ----------------LLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYG 379
+L YE V R + ++++G + + + LI P ++G
Sbjct: 292 SNTSDSESSSKGQEDAILSYEPVTRQEIHYARPVIILGPM---KDRVNDDLISEFPHKFG 348
Query: 380 TTVPYTSRRPKDSEREGQGYSFV-SRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVV 438
+ VP+T+R +D+E +GQ Y FV SR +ME D++ +++E G++ NLYGT I S+R V
Sbjct: 349 SCVPHTTRPRRDNEVDGQDYHFVVSREQMEKDIQDNKFIEAGQFNDNLYGTSIQSVRAVA 408
Query: 439 AAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADL 498
GK C+LDV+ A+K L+ A+ P +FI+ E L MNR + T
Sbjct: 409 ERGKHCILDVSGNAIKRLQQAQLYPIAIFIKPKSIEALMEMNR----------RQTYEQA 458
Query: 499 RRTVEESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVP 547
+ +++ ++++ +G YF + +LE + +++ +E WVP
Sbjct: 459 NKIYDKAMKLEQEFGEYFTAIVQGDSLEEIYNKIKQIIEDQSGHYIWVP 507
>gi|218156270 chapsyn-110 isoform 4 [Homo sapiens]
Length = 334
Score = 166 bits (420), Expect = 5e-41
Identities = 102/329 (31%), Positives = 172/329 (52%), Gaps = 25/329 (7%)
Query: 226 RQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHV--EGGSA--G 281
R ++V+ FDYD ++DS +P + GL F GD+L ++N D WWQA V EG S G
Sbjct: 19 RSLYVRAMFDYDKSKDSGLPSQ--GLSFKYGDILHVINASDDEWWQARRVMLEGDSEEMG 76
Query: 282 LIPSQLLEEKRKAFVKRDLELTPNSGTLC--GSLSGKKKKRMMYLTTKNAEFDRHELLIY 339
+IPS+ E+++ + ++ G + G + G TK +L Y
Sbjct: 77 VIPSKRRVERKERARLKTVKFNAKPGVIDSKGDIPGLGDDGY---GTKTLRGQEDLILSY 133
Query: 340 EEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGY 399
E V R + ++++G + + + LI PD++G+ VP+T+R +D E +G+ Y
Sbjct: 134 EPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDY 190
Query: 400 SFV-SRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRT 458
FV SR +ME D++ +++E G+Y NLYGT + S+R V GK C+LDV+ A+K L+
Sbjct: 191 HFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCILDVSGNAIKRLQV 250
Query: 459 AEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDL 518
A+ P +FI+ E L MN K+LTE ++T + + ++++ +G YF
Sbjct: 251 AQLYPIAIFIKPRSLEPLMEMN----------KRLTEEQAKKTYDRAIKLEQEFGEYFTA 300
Query: 519 CLVNSNLERTFRELQTAMEKLRTEPQWVP 547
+ LE + + + +E+ W+P
Sbjct: 301 IVQGDTLEDIYNQCKLVIEEQSGPFIWIP 329
>gi|148539628 discs, large homolog 1 isoform 1 [Homo sapiens]
Length = 904
Score = 165 bits (418), Expect = 9e-41
Identities = 122/442 (27%), Positives = 207/442 (46%), Gaps = 63/442 (14%)
Query: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRN 206
G+ F + GGE + I+ IL GG G L GD I VN + + L+N
Sbjct: 475 GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKN 534
Query: 207 ASGSVILKILPSYQEPHLPR------------------------------QVFVKCHFDY 236
A +V I+ Y+ R ++V+ FDY
Sbjct: 535 AGQAVT--IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDY 592
Query: 237 DPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHV----EGGSAGLIPSQLLEEKR 292
D +DS +P + GL F GD+L ++N D WWQA V E G+IPS+ EK+
Sbjct: 593 DKTKDSGLPSQ--GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKK 650
Query: 293 KAFVKRDLEL---TPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHE---LLIYEEVARMP 346
+ + ++ T + G + + K K + + + R + +L YE V +
Sbjct: 651 ERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQE 710
Query: 347 PFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFV-SRG 405
+ ++++G + + + LI PD++G+ VP+T+R +D E +G+ Y FV SR
Sbjct: 711 VNYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSRE 767
Query: 406 EMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYV 465
+ME D++ +++E G+Y +LYGT + S+R V GK C+LDV+ A+K L+ A+ P
Sbjct: 768 QMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPIS 827
Query: 466 VFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNL 525
+FI+ E + MN K+LTE R+T E + ++++ + +F + L
Sbjct: 828 IFIKPKSMENIMEMN----------KRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTL 877
Query: 526 ERTFRELQTAMEKLRTEPQWVP 547
E + +++ +E+ WVP
Sbjct: 878 EDIYNQVKQIIEEQSGSYIWVP 899
>gi|148539578 discs, large homolog 1 isoform 2 [Homo sapiens]
Length = 926
Score = 162 bits (409), Expect = 1e-39
Identities = 123/464 (26%), Positives = 209/464 (45%), Gaps = 85/464 (18%)
Query: 152 GVTFRVEGGE----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLRN 206
G+ F + GGE + I+ IL GG G L GD I VN + + L+N
Sbjct: 475 GLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKN 534
Query: 207 ASGSVILKILPSYQEPHLPR------------------------------QVFVKCHFDY 236
A +V I+ Y+ R ++V+ FDY
Sbjct: 535 AGQAVT--IVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDY 592
Query: 237 DPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHV----EGGSAGLIPSQLLEEKR 292
D +DS +P + GL F GD+L ++N D WWQA V E G+IPS+ EK+
Sbjct: 593 DKTKDSGLPSQ--GLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKK 650
Query: 293 KAFVKRDLELTPNSGTLCGSLSGKKKKRMM-----------YLTTKNAEFDRHE------ 335
+ + ++ + S + K+KK + + ++ D+H
Sbjct: 651 ERARLKTVKFNSKTRDKGQSFNDKRKKNLFSRKFPFYKNKDQSEQETSDADQHVTSNASD 710
Query: 336 -----------LLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPY 384
+L YE V + + ++++G + + + LI PD++G+ VP+
Sbjct: 711 SESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPM---KDRINDDLISEFPDKFGSCVPH 767
Query: 385 TSRRPKDSEREGQGYSFV-SRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKV 443
T+R +D E +G+ Y FV SR +ME D++ +++E G+Y +LYGT + S+R V GK
Sbjct: 768 TTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKH 827
Query: 444 CVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVE 503
C+LDV+ A+K L+ A+ P +FI+ E + MN K+LTE R+T E
Sbjct: 828 CILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMN----------KRLTEEQARKTFE 877
Query: 504 ESSRIQRGYGHYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVP 547
+ ++++ + +F + LE + +++ +E+ WVP
Sbjct: 878 RAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVP 921
>gi|14780902 membrane protein, palmitoylated 4 [Homo sapiens]
Length = 637
Score = 152 bits (384), Expect = 8e-37
Identities = 105/302 (34%), Positives = 169/302 (55%), Gaps = 18/302 (5%)
Query: 5 ATNSETAMQQVLDNLGSLPSATGAAELD-LIFLRGIMESPIVRSLAKAHERLEE---TKL 60
ATN + + Q+L + S + +++ + L ++ SP +++L K ++ L+E KL
Sbjct: 21 ATNPQNGLSQILRLVLQELSLFYSRDVNGVCLLYDLLHSPWLQALLKIYDCLQEFKEKKL 80
Query: 61 EAVRDNNLELVQEILRDLAHVAEQSSTAAELAHILQEPHFQSLLETHDSVASKTYETPPP 120
+ L E++ +L S EL +LQ PHF++LL HD++A K +E
Sbjct: 81 VPATPHAQVLSYEVV-ELLRETPTSPEIQELRQMLQAPHFKALLSAHDTIAQKDFE---- 135
Query: 121 SPGLDPTFSNQPVPPDAVRMVGIRKTAGEHLGVTFRVEG--GELVIARILHGGMVAQQGL 178
P L P N P +A+R+V + K + LG T + G++++ARI+HGG+ + GL
Sbjct: 136 -PLLPPLPDNIPESEEAMRIVCLVKNQ-QPLGATIKRHEMTGDILVARIIHGGLAERSGL 193
Query: 179 LHVGDIIKEVNGQPV-GSDPRALQELLRNASGSVILKILPSYQEPHLPRQ-VFVKCHFDY 236
L+ GD + EVNG V G DP + +L + G+++ K++P P +Q V+V+ +Y
Sbjct: 194 LYAGDKLVEVNGVSVEGLDPEQVIHILAMSRGTIMFKVVPVSDPPVNSQQMVYVRAMTEY 253
Query: 237 DPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGS--AGLIPS-QLLEEKRK 293
P D IPC +AGL F GD+LQIV+Q+DA WWQA + + AGL+PS LL+ K++
Sbjct: 254 WPQEDPDIPCMDAGLPFQKGDILQIVDQNDALWWQARKISDPATCAGLVPSNHLLKRKQR 313
Query: 294 AF 295
F
Sbjct: 314 EF 315
Score = 152 bits (384), Expect = 8e-37
Identities = 75/218 (34%), Positives = 129/218 (59%), Gaps = 5/218 (2%)
Query: 339 YEEVARM---PPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSERE 395
YEEV R P + + +VL+G GVG L+ +LI ++P + + VP+T+R K E
Sbjct: 413 YEEVVRYQRRPSDKYRLIVLMGPSGVGVNELRRQLIEFNPSHFQSAVPHTTRTKKSYEMN 472
Query: 396 GQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKV 455
G+ Y +VS+ E + + R LE+GEY+G+LYGT +D+++ V+ GK+CV+D+ PQ ++
Sbjct: 473 GREYHYVSKETFENLIYSHRMLEYGEYKGHLYGTSVDAVQTVLVEGKICVMDLEPQDIQG 532
Query: 456 LRTAEFVPYVVFIEAPDFETLR--AMNRAALESGISTKQLTEADLRRTVEESSRIQRGYG 513
+RT E PYV+FI+ + ++ N + + + DL+ + R++ +G
Sbjct: 533 VRTHELKPYVIFIKPSNMRCMKQSRKNAKVITDYYVDMKFKDEDLQEMENLAQRMETQFG 592
Query: 514 HYFDLCLVNSNLERTFRELQTAMEKLRTEPQWVPVSWV 551
+FD +VN +L +L +A++K + EPQWVP +W+
Sbjct: 593 QFFDHVIVNDSLHDACAQLLSAIQKAQEEPQWVPATWI 630
>gi|4557529 post-synaptic density protein 95 isoform 1 [Homo
sapiens]
Length = 767
Score = 148 bits (373), Expect = 1e-35
Identities = 128/502 (25%), Positives = 213/502 (42%), Gaps = 84/502 (16%)
Query: 87 TAAELAHILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKT 146
T + H+ E S L T A SP + +P + R+V R +
Sbjct: 304 TTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGS 363
Query: 147 AGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPV--GSDPRA----- 199
G + +G + I+ IL GG G L GD I VNG + S +A
Sbjct: 364 TGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALK 423
Query: 200 --------------------------LQELLRNAS---GSVILKILPSYQEPHLPRQVFV 230
L+E L N+S G+ L+ P R ++
Sbjct: 424 NAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK-------RGFYI 476
Query: 231 KCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSA----GLIPSQ 286
+ FDYD +D + RF GD+L +++ D WWQA V S G IPS+
Sbjct: 477 RALFDYDKTKDCGFLSQALSFRF--GDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSK 534
Query: 287 LLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMP 346
E+R E + GS SG + + +L YE V +M
Sbjct: 535 RRVERR--------EWSRLKAKDWGSSSGSQGRE-------------DSVLSYETVTQME 573
Query: 347 PFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVS-RG 405
+ ++++G + + L+ PD++G+ VP+T+R ++ E +G+ Y FVS R
Sbjct: 574 VHYARPIIILGPT---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSRE 630
Query: 406 EMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYV 465
+ME D++A +++E G+Y +LYGT + S+R V GK C+LDV+ AV+ L+ A P
Sbjct: 631 KMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIA 690
Query: 466 VFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNL 525
+FI E + +N K++TE R+ + ++++++ + F + +
Sbjct: 691 IFIRPRSLENVLEIN----------KRITEEQARKAFDRATKLEQEFTECFSAIVEGDSF 740
Query: 526 ERTFRELQTAMEKLRTEPQWVP 547
E + +++ +E L WVP
Sbjct: 741 EEIYHKVKRVIEDLSGPYIWVP 762
Score = 31.6 bits (70), Expect = 2.0
Identities = 47/170 (27%), Positives = 63/170 (37%), Gaps = 41/170 (24%)
Query: 88 AAELAHILQEPHFQSLLETHDSVASKTYE----------TPP--PSPGLDPTFSNQP--- 132
A L +L FQ+LL+ D + E TPP SP P +N P
Sbjct: 23 APPLLTVLHSDLFQALLDILDYYEASLSESQKYRYQDEDTPPLEHSPAHLPNQANSPPVI 82
Query: 133 VPPDAVRMVG----IRKTAGE-----------HLGVTFRVEGG----------ELVIARI 167
V D + G + T GE + G+ F + GG + I +I
Sbjct: 83 VNTDTLEAPGYELQVNGTEGEMEYEEITLERGNSGLGFSIAGGTDNPHIGDDPSIFITKI 142
Query: 168 LHGGMVAQQGLLHVGDIIKEVNGQPVGS-DPRALQELLRNASGSVILKIL 216
+ GG AQ G L V D I VN V A E L+ A V L ++
Sbjct: 143 IPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEAGSIVRLYVM 192
>gi|192447426 post-synaptic density protein 95 isoform 2 [Homo
sapiens]
Length = 721
Score = 148 bits (373), Expect = 1e-35
Identities = 128/502 (25%), Positives = 213/502 (42%), Gaps = 84/502 (16%)
Query: 87 TAAELAHILQEPHFQSLLETHDSVASKTYETPPPSPGLDPTFSNQPVPPDAVRMVGIRKT 146
T + H+ E S L T A SP + +P + R+V R +
Sbjct: 258 TTSYSQHLDNEISHSSYLGTDYPTAMTPTSPRRYSPVAKDLLGEEDIPREPRRIVIHRGS 317
Query: 147 AGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNGQPV--GSDPRA----- 199
G + +G + I+ IL GG G L GD I VNG + S +A
Sbjct: 318 TGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDQILSVNGVDLRNASHEQAAIALK 377
Query: 200 --------------------------LQELLRNAS---GSVILKILPSYQEPHLPRQVFV 230
L+E L N+S G+ L+ P R ++
Sbjct: 378 NAGQTVTIIAQYKPEEYSRFEAKIHDLREQLMNSSLGSGTASLRSNPK-------RGFYI 430
Query: 231 KCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQDDANWWQACHVEGGSA----GLIPSQ 286
+ FDYD +D + RF GD+L +++ D WWQA V S G IPS+
Sbjct: 431 RALFDYDKTKDCGFLSQALSFRF--GDVLHVIDASDEEWWQARRVHSDSETDDIGFIPSK 488
Query: 287 LLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMP 346
E+R E + GS SG + + +L YE V +M
Sbjct: 489 RRVERR--------EWSRLKAKDWGSSSGSQGRE-------------DSVLSYETVTQME 527
Query: 347 PFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVS-RG 405
+ ++++G + + L+ PD++G+ VP+T+R ++ E +G+ Y FVS R
Sbjct: 528 VHYARPIIILGPT---KDRANDDLLSEFPDKFGSCVPHTTRPKREYEIDGRDYHFVSSRE 584
Query: 406 EMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYV 465
+ME D++A +++E G+Y +LYGT + S+R V GK C+LDV+ AV+ L+ A P
Sbjct: 585 KMEKDIQAHKFIEAGQYNSHLYGTSVQSVREVAEQGKHCILDVSANAVRRLQAAHLHPIA 644
Query: 466 VFIEAPDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNL 525
+FI E + +N K++TE R+ + ++++++ + F + +
Sbjct: 645 IFIRPRSLENVLEIN----------KRITEEQARKAFDRATKLEQEFTECFSAIVEGDSF 694
Query: 526 ERTFRELQTAMEKLRTEPQWVP 547
E + +++ +E L WVP
Sbjct: 695 EEIYHKVKRVIEDLSGPYIWVP 716
Score = 30.4 bits (67), Expect = 4.4
Identities = 38/129 (29%), Positives = 51/129 (39%), Gaps = 28/129 (21%)
Query: 116 ETPP--PSPGLDPTFSNQP---VPPDAVRMVG-IRKTAGE-----------HLGVTFRVE 158
+TPP SP P +N P V D + G + T GE + G+ F +
Sbjct: 18 DTPPLEHSPAHLPNQANSPPVIVNTDTLEAPGYVNGTEGEMEYEEITLERGNSGLGFSIA 77
Query: 159 GG----------ELVIARILHGGMVAQQGLLHVGDIIKEVNGQPVGS-DPRALQELLRNA 207
GG + I +I+ GG AQ G L V D I VN V A E L+ A
Sbjct: 78 GGTDNPHIGDDPSIFITKIIPGGAAAQDGRLRVNDSILFVNEVDVREVTHSAAVEALKEA 137
Query: 208 SGSVILKIL 216
V L ++
Sbjct: 138 GSIVRLYVM 146
>gi|226874833 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 109 bits (272), Expect = 7e-24
Identities = 57/192 (29%), Positives = 103/192 (53%), Gaps = 13/192 (6%)
Query: 351 KTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEAD 410
+ +VL G G G+ +L +L+ +G +V +T+R P+ E G+ Y FV+R M+ D
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 411 VRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEA 470
+ AG ++EH E+ GNLYGT +++ V A ++CVLDV+ Q V+ ++ + P + ++
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 471 PDF----ETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLE 526
P + LR N ES + +AD+ + E FD+ ++N +L+
Sbjct: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPG---------LFDVVIINDSLD 175
Query: 527 RTFRELQTAMEK 538
+ + EL+ A+ +
Sbjct: 176 QAYAELKEALSE 187
>gi|226874831 guanylate kinase 1 isoform a [Homo sapiens]
Length = 218
Score = 109 bits (272), Expect = 7e-24
Identities = 57/192 (29%), Positives = 103/192 (53%), Gaps = 13/192 (6%)
Query: 351 KTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEAD 410
+ +VL G G G+ +L +L+ +G +V +T+R P+ E G+ Y FV+R M+ D
Sbjct: 26 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 85
Query: 411 VRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEA 470
+ AG ++EH E+ GNLYGT +++ V A ++CVLDV+ Q V+ ++ + P + ++
Sbjct: 86 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 145
Query: 471 PDF----ETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLE 526
P + LR N ES + +AD+ + E FD+ ++N +L+
Sbjct: 146 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPG---------LFDVVIINDSLD 196
Query: 527 RTFRELQTAMEK 538
+ + EL+ A+ +
Sbjct: 197 QAYAELKEALSE 208
>gi|4504221 guanylate kinase 1 isoform b [Homo sapiens]
Length = 197
Score = 109 bits (272), Expect = 7e-24
Identities = 57/192 (29%), Positives = 103/192 (53%), Gaps = 13/192 (6%)
Query: 351 KTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEAD 410
+ +VL G G G+ +L +L+ +G +V +T+R P+ E G+ Y FV+R M+ D
Sbjct: 5 RPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRD 64
Query: 411 VRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEA 470
+ AG ++EH E+ GNLYGT +++ V A ++CVLDV+ Q V+ ++ + P + ++
Sbjct: 65 IAAGDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQP 124
Query: 471 PDF----ETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLE 526
P + LR N ES + +AD+ + E FD+ ++N +L+
Sbjct: 125 PSLHVLEQRLRQRNTETEESLVKRLAAAQADMESSKEPG---------LFDVVIINDSLD 175
Query: 527 RTFRELQTAMEK 538
+ + EL+ A+ +
Sbjct: 176 QAYAELKEALSE 187
>gi|10092691 tight junction protein 3 [Homo sapiens]
Length = 952
Score = 58.9 bits (141), Expect = 1e-08
Identities = 86/437 (19%), Positives = 163/437 (37%), Gaps = 85/437 (19%)
Query: 143 IRKTAGEHLGVTFRVEGGE---LVIARILHGGMVAQQGLLHVGDIIKEVNGQP------- 192
+R G+ +G+ R+ GG + ++ + G QG+ GD I +VN P
Sbjct: 417 VRFLKGKSIGL--RLAGGNDVGIFVSGVQAGSPADGQGIQE-GDQILQVNDVPFQNLTRE 473
Query: 193 ------VGSDPRALQELLRNASGSVILKILPSYQEPHLPRQVFVKCHFDYDPARDSLIPC 246
+G P EL+ + K++ S + +++ HF+ +P+ S
Sbjct: 474 EAVQFLLGLPPGEEMELVTQRKQDIFWKMVQS----RVGDSFYIRTHFELEPSPPS---- 525
Query: 247 KEAGLRFNAGDLLQIVNQDDANWWQACHVEGG--------------SAGLIPSQLLEEKR 292
GL F GD+ +++ Q+ H GG G+IP+Q E+
Sbjct: 526 ---GLGFTRGDVFHVLDTLHPGPGQS-HARGGHWLAVRMGRDLREQERGIIPNQSRAEQL 581
Query: 293 KAFVKRDLELTPNSGTLCGSLSGKKKKRMMYL---TTKNAEFDRHELLIYEEVARMPPFR 349
+ + G+ GS + + R+ L K + R +L R PP+
Sbjct: 582 ASLEAAQRAVGVGPGSSAGSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYE 641
Query: 350 RKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEA 409
R L S K +++ P T+ P E VSR + +
Sbjct: 642 RVVL--------REASFKRPVVILGPVADIAMQKLTAEMPDQFEIA----ETVSRTDSPS 689
Query: 410 DVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIE 469
+ ++D++R + K +LDV P A++ L ++ P VVF
Sbjct: 690 KI-----------------IKLDTVRVIAEKDKHALLDVTPSAIERLNYVQYYPIVVFFI 732
Query: 470 APDFETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCL-VNSNLERT 528
L+A+ + + + RR ++ ++++ H F + +N +
Sbjct: 733 PESRPALKALRQWLAPA-------SRRSTRRLYAQAQKLRKHSSHLFTATIPLNGTSDTW 785
Query: 529 FRELQTAMEKLRTEPQW 545
++EL+ + + +T P W
Sbjct: 786 YQELKAIIREQQTRPIW 802
Score = 32.7 bits (73), Expect = 0.89
Identities = 25/89 (28%), Positives = 42/89 (47%), Gaps = 8/89 (8%)
Query: 131 QPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEVNG 190
Q V V+ V +++ E GV G ++ I I G+ A+ L GD+I ++NG
Sbjct: 205 QDVQMKPVKSVLVKRRDSEEFGVKL---GSQIFIKHITDSGLAARHRGLQEGDLILQING 261
Query: 191 QPVGSDPRALQE---LLRNASGSVILKIL 216
V S +L + L+ + G + L +L
Sbjct: 262 --VSSQNLSLNDTRRLIEKSEGKLSLLVL 288
>gi|42518065 tight junction protein 2 (zona occludens 2) isoform 2
[Homo sapiens]
Length = 1043
Score = 52.8 bits (125), Expect = 8e-07
Identities = 95/466 (20%), Positives = 179/466 (38%), Gaps = 97/466 (20%)
Query: 116 ETPPPSPGLDPTFSNQPVPPDAV------RMVGIRKTAGEHLGVTFRVEGGE---LVIAR 166
+ P P P P +P P D +MV +K G+ +G+ R+ GG + +A
Sbjct: 482 DPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKK--GDSVGL--RLAGGNDVGIFVAG 537
Query: 167 ILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPR--ALQELLRNASGSVILKILPSYQEPHL 224
I G Q+GL GD I +VN Q R A+ LL G ++ + S + +
Sbjct: 538 IQEGTSAEQEGLQE-GDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYR 596
Query: 225 P-------RQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQ----DDANWWQAC 273
F++ HF+ + L F G++ ++V+ NW
Sbjct: 597 DILACGRGDSFFIRSHFECEKETPQ-------SLAFTRGEVFRVVDTLYDGKLGNWLAVR 649
Query: 274 HVEGGSAGLIPSQLLEEKRKAFVKRDLELTPNSGT------LCGSLSGKKK------KRM 321
GLIP++ E+ + + N+G + G SG KK + +
Sbjct: 650 IGNELEKGLIPNKSRAEQMASVQNAQRD---NAGDRADFWRMRGQRSGVKKNLRKSREDL 706
Query: 322 MYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTT 381
+ + + +F +E ++ E F+R ++ + L N+L PD + T
Sbjct: 707 TAVVSVSTKFPAYERVLLREAG----FKRPVVLFGPIADIAMEKLANEL----PDWFQTA 758
Query: 382 VPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAG 441
PKD+ E S G + R++++R ++
Sbjct: 759 ----KTEPKDAGSEK------STGVV----------------------RLNTVRQIIEQD 786
Query: 442 KVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRT 501
K +LDV P+AV +L ++ P V+F + ++ M + + R+
Sbjct: 787 KHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQ-------RLNPTSNKSSRKL 839
Query: 502 VEESSRIQRGYGHYFDLCL-VNSNLERTFRELQTAMEKLRTEPQWV 546
++++++++ H F + +NS + F L+ ++ + E WV
Sbjct: 840 FDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 34.3 bits (77), Expect = 0.31
Identities = 27/105 (25%), Positives = 45/105 (42%), Gaps = 12/105 (11%)
Query: 119 PPSPGLDPTFSNQPVP-----PDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMV 173
P S + S P P P + ++ ++ A E G+ G ++ + + G+
Sbjct: 282 PRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRL---GSQIFVKEMTRTGLA 338
Query: 174 AQQGLLHVGDIIKEVNGQPVG----SDPRALQELLRNASGSVILK 214
+ G LH GDII ++NG +D R L E R V+L+
Sbjct: 339 TKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
>gi|42518070 tight junction protein 2 (zona occludens 2) isoform 1
[Homo sapiens]
Length = 1190
Score = 52.8 bits (125), Expect = 8e-07
Identities = 95/466 (20%), Positives = 179/466 (38%), Gaps = 97/466 (20%)
Query: 116 ETPPPSPGLDPTFSNQPVPPDAV------RMVGIRKTAGEHLGVTFRVEGGE---LVIAR 166
+ P P P P +P P D +MV +K G+ +G+ R+ GG + +A
Sbjct: 482 DPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKK--GDSVGL--RLAGGNDVGIFVAG 537
Query: 167 ILHGGMVAQQGLLHVGDIIKEVNGQPVGSDPR--ALQELLRNASGSVILKILPSYQEPHL 224
I G Q+GL GD I +VN Q R A+ LL G ++ + S + +
Sbjct: 538 IQEGTSAEQEGLQE-GDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQSRADVYR 596
Query: 225 P-------RQVFVKCHFDYDPARDSLIPCKEAGLRFNAGDLLQIVNQ----DDANWWQAC 273
F++ HF+ + L F G++ ++V+ NW
Sbjct: 597 DILACGRGDSFFIRSHFECEKETPQ-------SLAFTRGEVFRVVDTLYDGKLGNWLAVR 649
Query: 274 HVEGGSAGLIPSQLLEEKRKAFVKRDLELTPNSGT------LCGSLSGKKK------KRM 321
GLIP++ E+ + + N+G + G SG KK + +
Sbjct: 650 IGNELEKGLIPNKSRAEQMASVQNAQRD---NAGDRADFWRMRGQRSGVKKNLRKSREDL 706
Query: 322 MYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQGVGRRSLKNKLIMWDPDRYGTT 381
+ + + +F +E ++ E F+R ++ + L N+L PD + T
Sbjct: 707 TAVVSVSTKFPAYERVLLREAG----FKRPVVLFGPIADIAMEKLANEL----PDWFQTA 758
Query: 382 VPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAG 441
PKD+ E S G + R++++R ++
Sbjct: 759 ----KTEPKDAGSEK------STGVV----------------------RLNTVRQIIEQD 786
Query: 442 KVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDFETLRAMNRAALESGISTKQLTEADLRRT 501
K +LDV P+AV +L ++ P V+F + ++ M + + R+
Sbjct: 787 KHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGVKTMRQ-------RLNPTSNKSSRKL 839
Query: 502 VEESSRIQRGYGHYFDLCL-VNSNLERTFRELQTAMEKLRTEPQWV 546
++++++++ H F + +NS + F L+ ++ + E WV
Sbjct: 840 FDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQGEAVWV 885
Score = 34.3 bits (77), Expect = 0.31
Identities = 27/105 (25%), Positives = 45/105 (42%), Gaps = 12/105 (11%)
Query: 119 PPSPGLDPTFSNQPVP-----PDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMV 173
P S + S P P P + ++ ++ A E G+ G ++ + + G+
Sbjct: 282 PRSRSREHPHSRSPSPEPRGRPGPIGVLLMKSRANEEYGLRL---GSQIFVKEMTRTGLA 338
Query: 174 AQQGLLHVGDIIKEVNGQPVG----SDPRALQELLRNASGSVILK 214
+ G LH GDII ++NG +D R L E R V+L+
Sbjct: 339 TKDGNLHEGDIILKINGTVTENMSLTDARKLIEKSRGKLQLVVLR 383
>gi|21389483 leucine-rich repeats and guanylate kinase domain
containing [Homo sapiens]
Length = 825
Score = 51.6 bits (122), Expect = 2e-06
Identities = 38/180 (21%), Positives = 80/180 (44%), Gaps = 4/180 (2%)
Query: 353 LVLIGAQGVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVR 412
L+L G + G+R L ++L + +T+R P E + Y F+S+ + V
Sbjct: 417 LILAGPEACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQDVFDEMVN 476
Query: 413 AGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPD 472
G+++ Y + YG D++ G+ G + + + V+ L+ + F P + + +
Sbjct: 477 MGKFILTFSYGNHKYGLNRDTVEGIARDGLASCIHMEIEGVRSLKYSYFEPRYILVVPMN 536
Query: 473 FETLRAMNRAALESGISTKQLTEADLRRTVEESSRIQRGYGHYFDLCLVNSNLERTFREL 532
E R G+ ++ E + R V+ +I + + YFD + +L+ +++L
Sbjct: 537 KEKYEGYLR---RKGLFSRAEIEFAVSR-VDLYIKINQNFPGYFDEVINADDLDVAYQKL 592
>gi|218505835 membrane-associated guanylate kinase-related 3
isoform 1 [Homo sapiens]
Length = 1481
Score = 50.1 bits (118), Expect = 5e-06
Identities = 23/52 (44%), Positives = 32/52 (61%)
Query: 378 YGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGT 429
Y T+P T+R P+D E G Y+F+S + +A +G LE G Y+GN YGT
Sbjct: 139 YLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGT 190
Score = 38.1 bits (87), Expect = 0.021
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 6/72 (8%)
Query: 152 GVTFRVEGGE-----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLR 205
G F + GG+ L I R+ G + G +HVGD I E+NG+P G EL++
Sbjct: 1030 GFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Query: 206 NASGSVILKILP 217
V+L + P
Sbjct: 1090 AGGNKVLLLLRP 1101
Score = 30.4 bits (67), Expect = 4.4
Identities = 16/48 (33%), Positives = 25/48 (52%), Gaps = 5/48 (10%)
Query: 151 LGVTFRVEGGE-----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV 193
+G F + GG+ L + +L G AQ G + GD+I ++NG V
Sbjct: 418 MGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV 465
Score = 30.0 bits (66), Expect = 5.8
Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 164 IARILHGGMVAQQGLLHVGDIIKEVNGQP-VGSDPRALQELLRNASGSVILKILPSYQEP 222
I R++ G + G L VGD I VNGQ V + +L+++A +V L ++ + +E
Sbjct: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI-AEEEH 940
Query: 223 HLP 225
H P
Sbjct: 941 HGP 943
>gi|155969695 membrane-associated guanylate kinase-related 3
isoform 2 [Homo sapiens]
Length = 1125
Score = 50.1 bits (118), Expect = 5e-06
Identities = 23/52 (44%), Positives = 32/52 (61%)
Query: 378 YGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGT 429
Y T+P T+R P+D E G Y+F+S + +A +G LE G Y+GN YGT
Sbjct: 139 YLRTIPCTTRAPRDGEVPGVDYNFISVEQFKALEESGALLESGTYDGNFYGT 190
Score = 38.1 bits (87), Expect = 0.021
Identities = 24/72 (33%), Positives = 35/72 (48%), Gaps = 6/72 (8%)
Query: 152 GVTFRVEGGE-----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV-GSDPRALQELLR 205
G F + GG+ L I R+ G + G +HVGD I E+NG+P G EL++
Sbjct: 1030 GFGFSLRGGKEYNMGLFILRLAEDGPAIKDGRIHVGDQIVEINGEPTQGITHTRAIELIQ 1089
Query: 206 NASGSVILKILP 217
V+L + P
Sbjct: 1090 AGGNKVLLLLRP 1101
Score = 30.4 bits (67), Expect = 4.4
Identities = 16/48 (33%), Positives = 25/48 (52%), Gaps = 5/48 (10%)
Query: 151 LGVTFRVEGGE-----LVIARILHGGMVAQQGLLHVGDIIKEVNGQPV 193
+G F + GG+ L + +L G AQ G + GD+I ++NG V
Sbjct: 418 MGFGFTIIGGDRPDEFLQVKNVLKDGPAAQDGKIAPGDVIVDINGNCV 465
Score = 30.0 bits (66), Expect = 5.8
Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 2/63 (3%)
Query: 164 IARILHGGMVAQQGLLHVGDIIKEVNGQP-VGSDPRALQELLRNASGSVILKILPSYQEP 222
I R++ G + G L VGD I VNGQ V + +L+++A +V L ++ + +E
Sbjct: 882 IGRVIEGSPADRCGKLKVGDHISAVNGQSIVELSHDNIVQLIKDAGVTVTLTVI-AEEEH 940
Query: 223 HLP 225
H P
Sbjct: 941 HGP 943
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 48.5 bits (114), Expect = 2e-05
Identities = 92/453 (20%), Positives = 181/453 (39%), Gaps = 81/453 (17%)
Query: 120 PSPGLDPTFSNQP-VPPDAVRMVGIRKTAGEHLGVTFRVEGGE---LVIARILHGGMVAQ 175
PS G+ P +++ + ++++V RK G+ +G+ R+ GG + +A +L A+
Sbjct: 403 PSDGVLPNSTHEDGILRPSMKLVKFRK--GDSVGL--RLAGGNDVGIFVAGVLEDSPAAK 458
Query: 176 QGLLHVGDIIKEVNGQPVGSDPRA-----LQELLRNASGSVILK----ILPSYQEPHLPR 226
+GL GD I VN + R L +L + +++ + + E +
Sbjct: 459 EGL-EEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGD 517
Query: 227 QVFVKCHFDYDPARDSLIPCKEA--GLRFNAGDLLQIVN---QDDANWWQACHVEGGSAG 281
+++ HF+Y+ KE+ GL FN G++ ++V+ W A + G +
Sbjct: 518 SFYIRTHFEYE---------KESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRI-GKNHK 567
Query: 282 LIPSQLLEEKRKAFVKRDLELTPNSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEE 341
+ ++ K +A ++ T T G + + R + + +N R +L
Sbjct: 568 EVERGIIPNKNRAEQLASVQYTLPK-TAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPV 626
Query: 342 VARMPPFRRKTLVLIGAQ------GVGRRSLKNKLIMWDPDRYGTTVPYTSRRPKDSERE 395
+ P + R L G G + KL +PD Y P+D+ +
Sbjct: 627 QTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIY----QIAKSEPRDAGTD 682
Query: 396 GQGYSFVSRGEMEADVRAGRYLEHGEYEGNLYGTRIDSIRGVVAAGKVCVLDVNPQAVKV 455
+ + R+ +I+ ++ K +LDV P AV
Sbjct: 683 QRSSGII---------------------------RLHTIKQIIDQDKHALLDVTPNAVDR 715
Query: 456 LRTAEFVPYVVFIEAPDFETLRAMN-RAALESGISTKQLTEADLRRTVEESSRIQRGYGH 514
L A++ P VVF+ + ++ M R ES S ++L E S ++++ H
Sbjct: 716 LNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKL--------YERSHKLRKNNHH 767
Query: 515 YFDLCL-VNSNLERTFRELQTAMEKLRTEPQWV 546
F + +NS + + L+ A+++ + + WV
Sbjct: 768 LFTTTINLNSMNDGWYGALKEAIQQQQNQLVWV 800
Score = 29.6 bits (65), Expect = 7.5
Identities = 17/62 (27%), Positives = 29/62 (46%), Gaps = 5/62 (8%)
Query: 129 SNQPVPPDAVRMVGIRKTAGEHLGVTFRVEGGELVIARILHGGMVAQQGLLHVGDIIKEV 188
S+QP P V +V RK E G+ + + I + A+ G + GD++ ++
Sbjct: 178 SSQPAKPTKVTLVKSRKN--EEYGLRL---ASHIFVKEISQDSLAARDGNIQEGDVVLKI 232
Query: 189 NG 190
NG
Sbjct: 233 NG 234
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.135 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,089,184
Number of Sequences: 37866
Number of extensions: 979296
Number of successful extensions: 3910
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 3592
Number of HSP's gapped (non-prelim): 349
length of query: 552
length of database: 18,247,518
effective HSP length: 107
effective length of query: 445
effective length of database: 14,195,856
effective search space: 6317155920
effective search space used: 6317155920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.