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Search of human proteins with 52630342
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|52630342 major histocompatibility complex, class I, C
precursor [Homo sapiens]
(366 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|52630342 major histocompatibility complex, class I, C precurs... 753 0.0
gi|17986001 major histocompatibility complex, class I, B precurs... 641 0.0
gi|24797067 major histocompatibility complex, class I, A precurs... 610 e-175
gi|4504415 major histocompatibility complex, class I, G precurso... 559 e-159
gi|62912479 major histocompatibility complex, class I, E precurs... 558 e-159
gi|149158702 major histocompatibility complex, class I, F isofor... 551 e-157
gi|149158698 major histocompatibility complex, class I, F isofor... 549 e-156
gi|89063265 PREDICTED: similar to MHC class I antigen [Homo sapi... 494 e-140
gi|149158700 major histocompatibility complex, class I, F isofor... 321 7e-88
gi|4504417 major histocompatibility complex, class I-related [Ho... 224 1e-58
gi|4504377 hemochromatosis protein isoform 1 precursor [Homo sap... 206 3e-53
gi|21040353 hemochromatosis protein isoform 9 precursor [Homo sa... 194 8e-50
gi|21040347 hemochromatosis protein isoform 6 precursor [Homo sa... 187 1e-47
gi|4502337 alpha-2-glycoprotein 1, zinc [Homo sapiens] 183 2e-46
gi|21040349 hemochromatosis protein isoform 7 precursor [Homo sa... 166 2e-41
gi|21040351 hemochromatosis protein isoform 8 precursor [Homo sa... 148 9e-36
gi|4557751 MHC class I polypeptide-related sequence A [Homo sapi... 143 3e-34
gi|209862839 Fc fragment of IgG, receptor, transporter, alpha [H... 141 1e-33
gi|4758346 Fc fragment of IgG, receptor, transporter, alpha [Hom... 141 1e-33
gi|167857788 MHC class I polypeptide-related sequence B [Homo sa... 138 7e-33
gi|21040355 hemochromatosis protein isoform 10 precursor [Homo s... 117 2e-26
gi|21040343 hemochromatosis protein isoform 4 precursor [Homo sa... 117 2e-26
gi|21040341 hemochromatosis protein isoform 3 precursor [Homo sa... 108 8e-24
gi|110618224 CD1A antigen precursor [Homo sapiens] 83 4e-16
gi|4502649 CD1D antigen precursor [Homo sapiens] 73 4e-13
gi|4502645 CD1B antigen precursor [Homo sapiens] 73 5e-13
gi|239758095 PREDICTED: similar to major histocompatibility comp... 70 4e-12
gi|239740749 PREDICTED: similar to major histocompatibility comp... 70 4e-12
gi|239740918 PREDICTED: similar to major histocompatibility comp... 69 5e-12
gi|4504399 major histocompatibility complex, class II, DM beta p... 67 2e-11
>gi|52630342 major histocompatibility complex, class I, C precursor
[Homo sapiens]
Length = 366
Score = 753 bits (1943), Expect = 0.0
Identities = 366/366 (100%), Positives = 366/366 (100%)
Query: 1 MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF 60
MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF
Sbjct: 1 MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF 60
Query: 61 DSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ 120
DSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ
Sbjct: 61 DSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ 120
Query: 121 RMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL 180
RMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL
Sbjct: 121 RMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL 180
Query: 181 RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT 240
RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT
Sbjct: 181 RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT 240
Query: 241 WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP 300
WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP
Sbjct: 241 WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP 300
Query: 301 SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDES 360
SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDES
Sbjct: 301 SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDES 360
Query: 361 LITCKA 366
LITCKA
Sbjct: 361 LITCKA 366
>gi|17986001 major histocompatibility complex, class I, B precursor
[Homo sapiens]
Length = 362
Score = 641 bits (1654), Expect = 0.0
Identities = 313/361 (86%), Positives = 331/361 (91%), Gaps = 1/361 (0%)
Query: 1 MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF 60
M VMAPR +LLLLS LALTETWA SHSMRYF T+VSRPGRGEPRFISVGYVDDTQFVRF
Sbjct: 1 MLVMAPRTVLLLLSAALALTETWAGSHSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRF 60
Query: 61 DSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ 120
DSDAASPR EPRAPW+EQEGPEYWDR TQ YK QAQ DR SLRNLRGYYNQSE GSHTLQ
Sbjct: 61 DSDAASPREEPRAPWIEQEGPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQ 120
Query: 121 RMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL 180
M GCD+GPDGRLLRG+DQ AYDGKDYIALNEDLRSWTAADTAAQITQRK EAAR AEQ
Sbjct: 121 SMYGCDVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWTAADTAAQITQRKWEAAREAEQR 180
Query: 181 RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT 240
RAYLEG CVEWLRRYLENGK+ L+RA+PPKTHVTHHP+SDHEATLRCWALGFYPAEITLT
Sbjct: 181 RAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITLT 240
Query: 241 WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP 300
WQRDGEDQTQDTELVETRPAGD TFQKWAAVVVPSG+EQRYTCH+QHEGL +PLTL WEP
Sbjct: 241 WQRDGEDQTQDTELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEP 300
Query: 301 SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDES 360
SSQ T+PI+GIVAGLAVL V+ V+GAVV A+MCRRKSSGGKGGS SQAACS+SAQGSD S
Sbjct: 301 SSQSTVPIVGIVAGLAVLAVV-VIGAVVAAVMCRRKSSGGKGGSYSQAACSDSAQGSDVS 359
Query: 361 L 361
L
Sbjct: 360 L 360
>gi|24797067 major histocompatibility complex, class I, A precursor
[Homo sapiens]
Length = 365
Score = 610 bits (1573), Expect = e-175
Identities = 298/365 (81%), Positives = 322/365 (88%), Gaps = 1/365 (0%)
Query: 1 MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF 60
M VMAPR LLLLLSG LALT+TWA SHSMRYF T+VSRPGRGEPRFI+VGYVDDTQFVRF
Sbjct: 1 MAVMAPRTLLLLLSGALALTQTWAGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRF 60
Query: 61 DSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ 120
DSDAAS R EPRAPW+EQEGPEYWD+ET+ K Q+Q DRV L LRGYYNQSE GSHT+Q
Sbjct: 61 DSDAASQRMEPRAPWIEQEGPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQ 120
Query: 121 RMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL 180
M GCD+G DGR LRGY Q AYDGKDYIALNEDLRSWTAAD AAQIT+RK EAA AEQL
Sbjct: 121 IMYGCDVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAAHEAEQL 180
Query: 181 RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT 240
RAYL+GTCVEWLRRYLENGKETLQR +PPKTH+THHP+SDHEATLRCWALGFYPAEITLT
Sbjct: 181 RAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITLT 240
Query: 241 WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP 300
WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSG+EQRYTCH+QHEGL +PLTL WE
Sbjct: 241 WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPKPLTLRWEL 300
Query: 301 SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSDES 360
SSQPTIPI+GI+AGL VL+ + GAVV A+M RRKSS KGGS +QAA S+SAQGSD S
Sbjct: 301 SSQPTIPIVGIIAGL-VLLGAVITGAVVAAVMWRRKSSDRKGGSYTQAASSDSAQGSDVS 359
Query: 361 LITCK 365
L CK
Sbjct: 360 LTACK 364
>gi|4504415 major histocompatibility complex, class I, G precursor
[Homo sapiens]
Length = 338
Score = 559 bits (1441), Expect = e-159
Identities = 271/338 (80%), Positives = 293/338 (86%), Gaps = 1/338 (0%)
Query: 1 MRVMAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRF 60
M VMAPR L LLLSG L LTETWA SHSMRYF AVSRPGRGEPRFI++GYVDDTQFVRF
Sbjct: 1 MVVMAPRTLFLLLSGALTLTETWAGSHSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRF 60
Query: 61 DSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQ 120
DSD+A PR EPRAPWVEQEGPEYW+ ET+ K AQ DR++L+ LRGYYNQSE SHTLQ
Sbjct: 61 DSDSACPRMEPRAPWVEQEGPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEASSHTLQ 120
Query: 121 RMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL 180
M GCDLG DGRLLRGY+Q AYDGKDY+ALNEDLRSWTAADTAAQI++RK EAA AEQ
Sbjct: 121 WMIGCDLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWTAADTAAQISKRKCEAANVAEQR 180
Query: 181 RAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLT 240
RAYLEGTCVEWL RYLENGKE LQRA+PPKTHVTHHP+ D+EATLRCWALGFYPAEI LT
Sbjct: 181 RAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIILT 240
Query: 241 WQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEP 300
WQRDGEDQTQD ELVETRPAGDGTFQKWAAVVVPSG+EQRYTCH+QHEGL EPL L W+
Sbjct: 241 WQRDGEDQTQDVELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPLMLRWKQ 300
Query: 301 SSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSS 338
SS PTIPIMGIVAGL VL + V GA V A++ R+KSS
Sbjct: 301 SSLPTIPIMGIVAGLVVLAAV-VTGAAVAAVLWRKKSS 337
>gi|62912479 major histocompatibility complex, class I, E precursor
[Homo sapiens]
Length = 358
Score = 558 bits (1437), Expect = e-159
Identities = 271/355 (76%), Positives = 303/355 (85%), Gaps = 1/355 (0%)
Query: 4 MAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSD 63
M LLLLLS LALT+TWA SHS++YF T+VSRPGRGEPRFISVGYVDDTQFVRFD+D
Sbjct: 1 MVDGTLLLLLSEALALTQTWAGSHSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDND 60
Query: 64 AASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMS 123
AASPR PRAPW+EQEG EYWDRET+ + AQ RV+LR LRGYYNQSE GSHTLQ M
Sbjct: 61 AASPRMVPRAPWMEQEGSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH 120
Query: 124 GCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAY 183
GC+LGPDGR LRGY+Q AYDGKDY+ LNEDLRSWTA DTAAQI+++K A AE RAY
Sbjct: 121 GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWTAVDTAAQISEQKSNDASEAEHQRAY 180
Query: 184 LEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQR 243
LE TCVEWL +YLE GKETL EPPKTHVTHHP+SDHEATLRCWALGFYPAEITLTWQ+
Sbjct: 181 LEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEITLTWQQ 240
Query: 244 DGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQ 303
DGE TQDTELVETRPAGDGTFQKWAAVVVPSG+EQRYTCH+QHEGL EP+TL W+P+SQ
Sbjct: 241 DGEGHTQDTELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEGLPEPVTLRWKPASQ 300
Query: 304 PTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGSD 358
PTIPI+GI+AGL VL+ V GAVV A++ R+KSSGGKGGS S+A S+SAQGS+
Sbjct: 301 PTIPIVGIIAGL-VLLGSVVSGAVVAAVIWRKKSSGGKGGSYSKAEWSDSAQGSE 354
>gi|149158702 major histocompatibility complex, class I, F isoform 1
precursor [Homo sapiens]
Length = 442
Score = 551 bits (1419), Expect = e-157
Identities = 271/354 (76%), Positives = 297/354 (83%), Gaps = 1/354 (0%)
Query: 4 MAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSD 63
MAPR+LLLLLSG LALT+TWA SHS+RYF TAVSRPGRGEPR+I+V YVDDTQF+RFDSD
Sbjct: 1 MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSD 60
Query: 64 AASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMS 123
AA PR EPR PWVEQEGP+YW+ T K AQ DRV+LRNL YNQSE GSHTLQ M+
Sbjct: 61 AAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMN 120
Query: 124 GCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAY 183
GCD+GPDGRLLRGY Q AYDGKDYI+LNEDLRSWTAADT AQITQR EA AE+ R Y
Sbjct: 121 GCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEEYAEEFRTY 180
Query: 184 LEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQR 243
LEG C+E LRRYLENGKETLQRA+PPK HV HHP+SDHEATLRCWALGFYPAEITLTWQR
Sbjct: 181 LEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEITLTWQR 240
Query: 244 DGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQ 303
DGE+QTQDTELVETRPAGDGTFQKWAAVVVP G+EQRYTCH+QHEGL +PL L WE S Q
Sbjct: 241 DGEEQTQDTELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLILRWEQSPQ 300
Query: 304 PTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAACSNSAQGS 357
PTIPI+GIVAGL VL + V GAVV A+M R+KSS GS SQAA + G+
Sbjct: 301 PTIPIVGIVAGLVVLGAV-VTGAVVAAVMWRKKSSDRNRGSYSQAAAYSVVSGN 353
>gi|149158698 major histocompatibility complex, class I, F isoform 2
precursor [Homo sapiens]
Length = 346
Score = 549 bits (1415), Expect = e-156
Identities = 270/346 (78%), Positives = 294/346 (84%), Gaps = 1/346 (0%)
Query: 4 MAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSD 63
MAPR+LLLLLSG LALT+TWA SHS+RYF TAVSRPGRGEPR+I+V YVDDTQF+RFDSD
Sbjct: 1 MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSD 60
Query: 64 AASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMS 123
AA PR EPR PWVEQEGP+YW+ T K AQ DRV+LRNL YNQSE GSHTLQ M+
Sbjct: 61 AAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMN 120
Query: 124 GCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAY 183
GCD+GPDGRLLRGY Q AYDGKDYI+LNEDLRSWTAADT AQITQR EA AE+ R Y
Sbjct: 121 GCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEEYAEEFRTY 180
Query: 184 LEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQR 243
LEG C+E LRRYLENGKETLQRA+PPK HV HHP+SDHEATLRCWALGFYPAEITLTWQR
Sbjct: 181 LEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEITLTWQR 240
Query: 244 DGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQ 303
DGE+QTQDTELVETRPAGDGTFQKWAAVVVP G+EQRYTCH+QHEGL +PL L WE S Q
Sbjct: 241 DGEEQTQDTELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEGLPQPLILRWEQSPQ 300
Query: 304 PTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAA 349
PTIPI+GIVAGL VL + V GAVV A+M R+KSS GS SQAA
Sbjct: 301 PTIPIVGIVAGLVVLGAV-VTGAVVAAVMWRKKSSDRNRGSYSQAA 345
>gi|89063265 PREDICTED: similar to MHC class I antigen [Homo
sapiens]
Length = 366
Score = 494 bits (1271), Expect = e-140
Identities = 241/327 (73%), Positives = 271/327 (82%), Gaps = 5/327 (1%)
Query: 26 SHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWD 85
SHS+RYF TAVSRPG GEPRFISVGYVDDTQFVRFDSD+A+PR EPRAPW+EQEGPEYWD
Sbjct: 39 SHSLRYFYTAVSRPGLGEPRFISVGYVDDTQFVRFDSDSANPREEPRAPWMEQEGPEYWD 98
Query: 86 RETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGK 145
+T+ K AQ+ RV L LRGYYNQSE GSHTLQ M GCD+GPDGR LRG+ Q AYDG+
Sbjct: 99 EQTRIVKDTAQSFRVGLNTLRGYYNQSEAGSHTLQLMYGCDVGPDGRFLRGFMQDAYDGR 158
Query: 146 DYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQR 205
DYIALNEDLRSWTAADTAAQIT+RK EAA AAE+ R YLEG CVE LRRYLE GK+ L R
Sbjct: 159 DYIALNEDLRSWTAADTAAQITKRKREAAGAAERQRNYLEGRCVEGLRRYLETGKDALLR 218
Query: 206 AEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTF 265
A+PPK HVTHHP+S+ E TLRCWALGFYP EI+LTWQR+GEDQTQD ELVETRP+GDGTF
Sbjct: 219 ADPPKAHVTHHPISEREVTLRCWALGFYPEEISLTWQREGEDQTQDMELVETRPSGDGTF 278
Query: 266 QKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLG 325
QKWAA+VVPSG+EQRYTC +QHEGLQEPLTL WEP Q + IMGI+ GL +LVV V G
Sbjct: 279 QKWAALVVPSGEEQRYTCRVQHEGLQEPLTLRWEP-PQTSFLIMGIIVGLVLLVVALVAG 337
Query: 326 AVVTAMMCRRKSSGGKGGSCSQAACSN 352
AV+ R+K SG +G S+ +C N
Sbjct: 338 AVI----WRKKRSGREGREGSEFSCHN 360
>gi|149158700 major histocompatibility complex, class I, F isoform 3
precursor [Homo sapiens]
Length = 254
Score = 321 bits (822), Expect = 7e-88
Identities = 158/204 (77%), Positives = 172/204 (84%)
Query: 4 MAPRALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSD 63
MAPR+LLLLLSG LALT+TWA SHS+RYF TAVSRPGRGEPR+I+V YVDDTQF+RFDSD
Sbjct: 1 MAPRSLLLLLSGALALTDTWAGSHSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSD 60
Query: 64 AASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMS 123
AA PR EPR PWVEQEGP+YW+ T K AQ DRV+LRNL YNQSE GSHTLQ M+
Sbjct: 61 AAIPRMEPREPWVEQEGPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMN 120
Query: 124 GCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQLRAY 183
GCD+GPDGRLLRGY Q AYDGKDYI+LNEDLRSWTAADT AQITQR EA AE+ R Y
Sbjct: 121 GCDMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTAADTVAQITQRFYEAEEYAEEFRTY 180
Query: 184 LEGTCVEWLRRYLENGKETLQRAE 207
LEG C+E LRRYLENGKETLQRAE
Sbjct: 181 LEGECLELLRRYLENGKETLQRAE 204
Score = 55.1 bits (131), Expect = 1e-07
Identities = 33/51 (64%), Positives = 37/51 (72%), Gaps = 1/51 (1%)
Query: 299 EPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGSCSQAA 349
E S QPTIPI+GIVAGL VL + V GAVV A+M R+KSS GS SQAA
Sbjct: 204 EQSPQPTIPIVGIVAGLVVLGAV-VTGAVVAAVMWRKKSSDRNRGSYSQAA 253
>gi|4504417 major histocompatibility complex, class I-related [Homo
sapiens]
Length = 341
Score = 224 bits (570), Expect = 1e-58
Identities = 135/326 (41%), Positives = 188/326 (57%), Gaps = 14/326 (4%)
Query: 8 ALLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASP 67
A LL L L + + + +HS+RYF VS P G P FISVGYVD +DS +
Sbjct: 6 AFLLPLIIVLMVKHSDSRTHSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDS--VTR 63
Query: 68 RGEPRAPWV-EQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCD 126
+ EPRAPW+ E P++W+R TQ + Q +V L+ L+ +YN S GSHT QRM GC+
Sbjct: 64 QKEPRAPWMAENLAPDHWERYTQLLRGWQQMFKVELKRLQRHYNHS--GSHTYQRMIGCE 121
Query: 127 LGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARAAEQL--RAYL 184
L DG G+ Q AYDG+D++ N+D SW A D A ++ EA + E L + +L
Sbjct: 122 LLEDGSTT-GFLQYAYDGQDFLIFNKDTLSWLAVDNVAHTIKQAWEANQH-ELLYQKNWL 179
Query: 185 EGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRD 244
E C+ WL+R+LE GK+TLQR EPP V L C A GFYP EI +TW ++
Sbjct: 180 EEECIAWLKRFLEYGKDTLQRTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKN 239
Query: 245 GEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQP 304
GE+ Q+ + + P+GDGT+Q WA++ + Y+CH++H G+ L + P
Sbjct: 240 GEEIVQEIDYGDILPSGDGTYQAWASIELDPQSSNLYSCHVEHCGVHMVLQV---PQESE 296
Query: 305 TIP-IMGIVAGLAVLV-VLAVLGAVV 328
TIP +M V+G VLV VLA +G +V
Sbjct: 297 TIPLVMKAVSGSIVLVIVLAGVGVLV 322
>gi|4504377 hemochromatosis protein isoform 1 precursor [Homo
sapiens]
Length = 348
Score = 206 bits (524), Expect = 3e-53
Identities = 129/346 (37%), Positives = 183/346 (52%), Gaps = 13/346 (3%)
Query: 4 MAPRA----LLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVR 59
M PRA LLL+L L SHS+ Y S G F ++GYVDD FV
Sbjct: 1 MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVF 60
Query: 60 FDSDAASPRGEPRAPWVEQE-GPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHT 118
+D + S R EPR PWV + W + +Q K V + +N S++ SHT
Sbjct: 61 YDHE--SRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKE-SHT 117
Query: 119 LQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARA-A 177
LQ + GC++ D GY + YDG+D++ D W AA+ A T+ + E + A
Sbjct: 118 LQVILGCEMQEDNST-EGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRA 176
Query: 178 EQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEI 237
Q RAYLE C L++ LE G+ L + PP VTHH S TLRC AL +YP I
Sbjct: 177 RQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSS-VTTLRCRALNYYPQNI 235
Query: 238 TLTWQRDGEDQ-TQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTL 296
T+ W +D + ++ E + P GDGT+Q W + VP G+EQRYTC ++H GL +PL +
Sbjct: 236 TMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIV 295
Query: 297 SWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKG 342
WEPS T+ ++G+++G+AV VV+ +G + + R+ S G G
Sbjct: 296 IWEPSPSGTL-VIGVISGIAVFVVILFIGILFIILRKRQGSRGAMG 340
>gi|21040353 hemochromatosis protein isoform 9 precursor [Homo
sapiens]
Length = 325
Score = 194 bits (494), Expect = 8e-50
Identities = 114/301 (37%), Positives = 166/301 (55%), Gaps = 9/301 (2%)
Query: 45 RFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQE-GPEYWDRETQKYKRQAQADRVSLR 103
R + +GYVDD FV +D + S R EPR PWV + W + +Q K V
Sbjct: 23 RLLPLGYVDDQLFVFYDHE--SRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFW 80
Query: 104 NLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTA 163
+ +N S++ SHTLQ + GC++ D GY + YDG+D++ D W AA+
Sbjct: 81 TIMENHNHSKE-SHTLQVILGCEMQEDNST-EGYWKYGYDGQDHLEFCPDTLDWRAAEPR 138
Query: 164 AQITQRKLEAARA-AEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHE 222
A T+ + E + A Q RAYLE C L++ LE G+ L + PP VTHH S
Sbjct: 139 AWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSS-V 197
Query: 223 ATLRCWALGFYPAEITLTWQRDGEDQ-TQDTELVETRPAGDGTFQKWAAVVVPSGQEQRY 281
TLRC AL +YP IT+ W +D + ++ E + P GDGT+Q W + VP G+EQRY
Sbjct: 198 TTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRY 257
Query: 282 TCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGK 341
TC ++H GL +PL + WEPS T+ ++G+++G+AV VV+ +G + + R+ S G
Sbjct: 258 TCQVEHPGLDQPLIVIWEPSPSGTL-VIGVISGIAVFVVILFIGILFIILRKRQGSRGAM 316
Query: 342 G 342
G
Sbjct: 317 G 317
>gi|21040347 hemochromatosis protein isoform 6 precursor [Homo
sapiens]
Length = 334
Score = 187 bits (476), Expect = 1e-47
Identities = 122/346 (35%), Positives = 176/346 (50%), Gaps = 27/346 (7%)
Query: 4 MAPRA----LLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVR 59
M PRA LLL+L L SHS+ Y S G F ++GYVDD FV
Sbjct: 1 MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVF 60
Query: 60 FDSDAASPRGEPRAPWVEQE-GPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHT 118
+D + S R EPR PWV + W + +Q K V + +N S++ SHT
Sbjct: 61 YDHE--SRRVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKE-SHT 117
Query: 119 LQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARA-A 177
LQ + GC++ D GY + YDG+D++ D W AA+ A T+ + E + A
Sbjct: 118 LQVILGCEMQEDNST-EGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHKIRA 176
Query: 178 EQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEI 237
Q RAYLE C L++ LE G+ L + TLRC AL +YP I
Sbjct: 177 RQNRAYLERDCPAQLQQLLELGRGVLDQ---------------QVTTLRCRALNYYPQNI 221
Query: 238 TLTWQRDGEDQ-TQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTL 296
T+ W +D + ++ E + P GDGT+Q W + VP G+EQRYTC ++H GL +PL +
Sbjct: 222 TMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIV 281
Query: 297 SWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKG 342
WEPS T+ ++G+++G+AV VV+ +G + + R+ S G G
Sbjct: 282 IWEPSPSGTL-VIGVISGIAVFVVILFIGILFIILRKRQGSRGAMG 326
>gi|4502337 alpha-2-glycoprotein 1, zinc [Homo sapiens]
Length = 298
Score = 183 bits (465), Expect = 2e-46
Identities = 107/294 (36%), Positives = 158/294 (53%), Gaps = 8/294 (2%)
Query: 10 LLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRG 69
LLLL G E +S+ Y T +S+ P F ++G ++D QF R++S +
Sbjct: 11 LLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSK--DRKS 68
Query: 70 EPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGP 129
+P W + EG E W +++Q K + +L+++ YYN S +GSH LQ GC++
Sbjct: 69 QPMGLWRQVEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDS-NGSHVLQGRFGCEI-E 126
Query: 130 DGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAARA-AEQLRAYLEGTC 188
+ R + + YDGKDYI N+++ +W D AAQIT++K EA ++ +AYLE C
Sbjct: 127 NNRSSGAFWKYYYDGKDYIEFNKEIPAWVPFDPAAQITKQKWEAEPVYVQRAKAYLEEEC 186
Query: 189 VEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQ 248
LR+YL+ K L R +PP VT H + L+C A FYP +I + W R GE
Sbjct: 187 PATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHWTRAGE-- 244
Query: 249 TQDTEL-VETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPS 301
Q+ EL + G+GT+Q W V VP Y+CH+QH L +PL + WE S
Sbjct: 245 VQEPELRGDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHSSLAQPLVVPWEAS 298
>gi|21040349 hemochromatosis protein isoform 7 precursor [Homo
sapiens]
Length = 260
Score = 166 bits (421), Expect = 2e-41
Identities = 91/229 (39%), Positives = 132/229 (57%), Gaps = 5/229 (2%)
Query: 116 SHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAAR 175
SHTLQ + GC++ D GY + YDG+D++ D W AA+ A T+ + E +
Sbjct: 27 SHTLQVILGCEMQEDNST-EGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHK 85
Query: 176 A-AEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYP 234
A Q RAYLE C L++ LE G+ L + PP VTHH S TLRC AL +YP
Sbjct: 86 IRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSS-VTTLRCRALNYYP 144
Query: 235 AEITLTWQRDGEDQ-TQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEP 293
IT+ W +D + ++ E + P GDGT+Q W + VP G+EQRYTC ++H GL +P
Sbjct: 145 QNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQP 204
Query: 294 LTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKG 342
L + WEPS T+ ++G+++G+AV VV+ +G + + R+ S G G
Sbjct: 205 LIVIWEPSPSGTL-VIGVISGIAVFVVILFIGILFIILRKRQGSRGAMG 252
>gi|21040351 hemochromatosis protein isoform 8 precursor [Homo
sapiens]
Length = 246
Score = 148 bits (373), Expect = 9e-36
Identities = 84/229 (36%), Positives = 125/229 (54%), Gaps = 19/229 (8%)
Query: 116 SHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAAR 175
SHTLQ + GC++ D GY + YDG+D++ D W AA+ A T+ + E +
Sbjct: 27 SHTLQVILGCEMQEDNST-EGYWKYGYDGQDHLEFCPDTLDWRAAEPRAWPTKLEWERHK 85
Query: 176 A-AEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYP 234
A Q RAYLE C L++ LE G+ L + TLRC AL +YP
Sbjct: 86 IRARQNRAYLERDCPAQLQQLLELGRGVLDQ---------------QVTTLRCRALNYYP 130
Query: 235 AEITLTWQRDGEDQ-TQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEP 293
IT+ W +D + ++ E + P GDGT+Q W + VP G+EQRYTC ++H GL +P
Sbjct: 131 QNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQP 190
Query: 294 LTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKG 342
L + WEPS T+ ++G+++G+AV VV+ +G + + R+ S G G
Sbjct: 191 LIVIWEPSPSGTL-VIGVISGIAVFVVILFIGILFIILRKRQGSRGAMG 238
>gi|4557751 MHC class I polypeptide-related sequence A [Homo
sapiens]
Length = 383
Score = 143 bits (360), Expect = 3e-34
Identities = 103/353 (29%), Positives = 171/353 (48%), Gaps = 37/353 (10%)
Query: 9 LLLLLSGGLALTETWACS--HSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAAS 66
+ LLL+G A + HS+RY T +S G + F++ ++D F+R D
Sbjct: 6 VFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC- 64
Query: 67 PRGEPRAPWVEQE-GPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGC 125
R +P+ W E G + WDRET+ + R++L +++ ++G H+LQ + C
Sbjct: 65 -RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIK----DQKEGLHSLQEIRVC 119
Query: 126 DLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTA-----ADTAAQITQRKL-EAARAAEQ 179
++ D R YDG+ +++ N + + WT A T A + L E A +
Sbjct: 120 EIHEDNST-RSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKT 178
Query: 180 LRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITL 239
+ C++ LRRYL++G L+R PP +VT S+ T+ C A GFYP ITL
Sbjct: 179 HYHAMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITL 237
Query: 240 TWQRDGEDQTQDT-ELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSW 298
+W++DG + DT + + P G+GT+Q W A + G+EQR+TC+M+H G S
Sbjct: 238 SWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSG-----NHST 292
Query: 299 EPSSQPTIPIM---------GIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKG 342
P + ++ VA A+ V++ + C++K+S +G
Sbjct: 293 HPVPSGKVLVLQSHWQTFHVSAVAAAAIFVII-----IFYVRCCKKKTSAAEG 340
>gi|209862839 Fc fragment of IgG, receptor, transporter, alpha [Homo
sapiens]
Length = 365
Score = 141 bits (355), Expect = 1e-33
Identities = 109/336 (32%), Positives = 167/336 (49%), Gaps = 27/336 (8%)
Query: 9 LLLLLSGGLALTETWACSH-SMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASP 67
LL LL G L A SH S+ Y TAVS P G P F G++ Q++ ++S
Sbjct: 14 LLFLLPGSLG-----AESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNS--LRG 66
Query: 68 RGEPRAPWV-EQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCD 126
EP WV E + YW++ET + + + + + L G G +TLQ + GC+
Sbjct: 67 EAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGG------KGPYTLQGLLGCE 120
Query: 127 LGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADT---AAQITQRKLEAARAAEQLRAY 183
LGPD + + A +G+++ +N DL+ T A I+QR + +AA + +
Sbjct: 121 LGPDNTSVPTA-KFALNGEEF--MNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTF 177
Query: 184 LEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQR 243
L +C LR +LE G+ L+ EPP + P S + L C A FYP E+ L + R
Sbjct: 178 LLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLR 237
Query: 244 DGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQ 303
+G T + P DG+F +++ V SG E Y C +QH GL +PL + E ++
Sbjct: 238 NG--LAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAK 295
Query: 304 PTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSG 339
++ ++GIV G+ +L AV G A++ RR SG
Sbjct: 296 SSVLVVGIVIGVLLLTAAAVGG----ALLWRRMRSG 327
>gi|4758346 Fc fragment of IgG, receptor, transporter, alpha [Homo
sapiens]
Length = 365
Score = 141 bits (355), Expect = 1e-33
Identities = 109/336 (32%), Positives = 167/336 (49%), Gaps = 27/336 (8%)
Query: 9 LLLLLSGGLALTETWACSH-SMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASP 67
LL LL G L A SH S+ Y TAVS P G P F G++ Q++ ++S
Sbjct: 14 LLFLLPGSLG-----AESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNS--LRG 66
Query: 68 RGEPRAPWV-EQEGPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCD 126
EP WV E + YW++ET + + + + + L G G +TLQ + GC+
Sbjct: 67 EAEPCGAWVWENQVSWYWEKETTDLRIKEKLFLEAFKALGG------KGPYTLQGLLGCE 120
Query: 127 LGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADT---AAQITQRKLEAARAAEQLRAY 183
LGPD + + A +G+++ +N DL+ T A I+QR + +AA + +
Sbjct: 121 LGPDNTSVPTA-KFALNGEEF--MNFDLKQGTWGGDWPEALAISQRWQQQDKAANKELTF 177
Query: 184 LEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQR 243
L +C LR +LE G+ L+ EPP + P S + L C A FYP E+ L + R
Sbjct: 178 LLFSCPHRLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLR 237
Query: 244 DGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQ 303
+G T + P DG+F +++ V SG E Y C +QH GL +PL + E ++
Sbjct: 238 NG--LAAGTGQGDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAGLAQPLRVELESPAK 295
Query: 304 PTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSG 339
++ ++GIV G+ +L AV G A++ RR SG
Sbjct: 296 SSVLVVGIVIGVLLLTAAAVGG----ALLWRRMRSG 327
>gi|167857788 MHC class I polypeptide-related sequence B [Homo
sapiens]
Length = 383
Score = 138 bits (348), Expect = 7e-33
Identities = 94/332 (28%), Positives = 163/332 (49%), Gaps = 33/332 (9%)
Query: 27 HSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAASPRGEPRAPWVEQE-GPEYWD 85
HS+RY +S+ G + F++ G++D F+R+D R +P+ W E G + WD
Sbjct: 26 HSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYDRQKR--RAKPQGQWAENVLGAKTWD 83
Query: 86 RETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGK 145
ET+ Q R +L +++ + G H+LQ + C++ D RG YDG+
Sbjct: 84 TETEDLTENGQDLRRTLTHIK----DQKGGLHSLQEIRVCEIHEDSST-RGSRHFYYDGE 138
Query: 146 DYIALNEDLRSWT------AADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENG 199
+++ N + + T A A +T E A + ++ C++ L+RYL++G
Sbjct: 139 LFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHYRAMQADCLQKLQRYLKSG 198
Query: 200 KETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQTQDT-ELVETR 258
++R PP +VT +S+ T+ C A FYP ITLTW++DG + +T + +
Sbjct: 199 V-AIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWRQDGVSLSHNTQQWGDVL 257
Query: 259 PAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQ--------EPLTLSWEPSSQPTIPIMG 310
P G+GT+Q W A + G+EQR+TC+M+H G + L L + + P +
Sbjct: 258 PDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKALVLQSQRTDFPYVS--- 314
Query: 311 IVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKG 342
A + V++ +L C++K+S +G
Sbjct: 315 --AAMPCFVIIIIL----CVPCCKKKTSAAEG 340
>gi|21040355 hemochromatosis protein isoform 10 precursor [Homo
sapiens]
Length = 168
Score = 117 bits (293), Expect = 2e-26
Identities = 57/136 (41%), Positives = 83/136 (61%), Gaps = 3/136 (2%)
Query: 208 PPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQ-TQDTELVETRPAGDGTFQ 266
PP VTHH S TLRC AL +YP IT+ W +D + ++ E + P GDGT+Q
Sbjct: 27 PPLVKVTHHVTSS-VTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQ 85
Query: 267 KWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGA 326
W + VP G+EQRYTC ++H GL +PL + WEPS T+ ++G+++G+AV VV+ +G
Sbjct: 86 GWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTL-VIGVISGIAVFVVILFIGI 144
Query: 327 VVTAMMCRRKSSGGKG 342
+ + R+ S G G
Sbjct: 145 LFIILRKRQGSRGAMG 160
>gi|21040343 hemochromatosis protein isoform 4 precursor [Homo
sapiens]
Length = 256
Score = 117 bits (293), Expect = 2e-26
Identities = 57/136 (41%), Positives = 83/136 (61%), Gaps = 3/136 (2%)
Query: 208 PPKTHVTHHPLSDHEATLRCWALGFYPAEITLTWQRDGEDQ-TQDTELVETRPAGDGTFQ 266
PP VTHH S TLRC AL +YP IT+ W +D + ++ E + P GDGT+Q
Sbjct: 115 PPLVKVTHHVTSS-VTTLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQ 173
Query: 267 KWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGA 326
W + VP G+EQRYTC ++H GL +PL + WEPS T+ ++G+++G+AV VV+ +G
Sbjct: 174 GWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSGTL-VIGVISGIAVFVVILFIGI 232
Query: 327 VVTAMMCRRKSSGGKG 342
+ + R+ S G G
Sbjct: 233 LFIILRKRQGSRGAMG 248
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/94 (37%), Positives = 44/94 (46%), Gaps = 7/94 (7%)
Query: 4 MAPRA----LLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVR 59
M PRA LLL+L L SHS+ Y S G F ++GYVDD FV
Sbjct: 1 MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVF 60
Query: 60 FDSDAASPRGEPRAPWVEQE-GPEYWDRETQKYK 92
+D + S R EPR PWV + W + +Q K
Sbjct: 61 YDHE--SRRVEPRTPWVSSRISSQMWLQLSQSLK 92
>gi|21040341 hemochromatosis protein isoform 3 precursor [Homo
sapiens]
Length = 242
Score = 108 bits (270), Expect = 8e-24
Identities = 50/120 (41%), Positives = 76/120 (63%), Gaps = 2/120 (1%)
Query: 224 TLRCWALGFYPAEITLTWQRDGEDQ-TQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYT 282
TLRC AL +YP IT+ W +D + ++ E + P GDGT+Q W + VP G+EQRYT
Sbjct: 116 TLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYT 175
Query: 283 CHMQHEGLQEPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKG 342
C ++H GL +PL + WEPS T+ ++G+++G+AV VV+ +G + + R+ S G G
Sbjct: 176 CQVEHPGLDQPLIVIWEPSPSGTL-VIGVISGIAVFVVILFIGILFIILRKRQGSRGAMG 234
Score = 48.1 bits (113), Expect = 1e-05
Identities = 35/94 (37%), Positives = 44/94 (46%), Gaps = 7/94 (7%)
Query: 4 MAPRA----LLLLLSGGLALTETWACSHSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVR 59
M PRA LLL+L L SHS+ Y S G F ++GYVDD FV
Sbjct: 1 MGPRARPALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVF 60
Query: 60 FDSDAASPRGEPRAPWVEQE-GPEYWDRETQKYK 92
+D + S R EPR PWV + W + +Q K
Sbjct: 61 YDHE--SRRVEPRTPWVSSRISSQMWLQLSQSLK 92
>gi|110618224 CD1A antigen precursor [Homo sapiens]
Length = 327
Score = 82.8 bits (203), Expect = 4e-16
Identities = 59/230 (25%), Positives = 105/230 (45%), Gaps = 11/230 (4%)
Query: 101 SLRNLRGYYNQSE-DGSHTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTA 159
S +R Y ++ + + +Q GC+L G++ + Q AY G D+++ + SW
Sbjct: 94 SFEGIRRYAHELQFEYPFEIQVTGGCELH-SGKVSGSFLQLAYQGSDFVSFQNN--SWLP 150
Query: 160 ADTAAQITQRKLEAARAAEQ----LRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTH 215
A + + + + L TC ++ L+ GK LQR P+ ++H
Sbjct: 151 YPVAGNMAKHFCKVLNQNQHENDITHNLLSDTCPRFILGLLDAGKAHLQRQVKPEAWLSH 210
Query: 216 HPL-SDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP 274
P L C GFYP + + W R GE + Q T+ + P+ DGT+ A + V
Sbjct: 211 GPSPGPGHLQLVCHVSGFYPKPVWVMWMR-GEQEQQGTQRGDILPSADGTWYLRATLEVA 269
Query: 275 SGQEQRYTCHMQHEGLQ-EPLTLSWEPSSQPTIPIMGIVAGLAVLVVLAV 323
+G+ +C ++H L+ + + L WE S I+ ++ L +L+ LA+
Sbjct: 270 AGEAADLSCRVKHSSLEGQDIVLYWEHHSSVGFIILAVIVPLLLLIGLAL 319
>gi|4502649 CD1D antigen precursor [Homo sapiens]
Length = 335
Score = 73.2 bits (178), Expect = 4e-13
Identities = 62/226 (27%), Positives = 101/226 (44%), Gaps = 15/226 (6%)
Query: 119 LQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAAR--- 175
LQ +GC++ P G + A+ GKD ++ SW A ++
Sbjct: 114 LQVSAGCEVHP-GNASNNFFHVAFQGKDILSFQGT--SWEPTQEAPLWVNLAIQVLNQDK 170
Query: 176 -AAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPL-SDHEATLRCWALGFY 233
E ++ L GTC +++ LE+GK L++ PK ++ P L C GFY
Sbjct: 171 WTRETVQWLLNGTCPQFVSGLLESGKSELKKQVKPKAWLSRGPSPGPGRLLLVCHVSGFY 230
Query: 234 PAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQ-E 292
P + + W R GE + Q T+ + P D T+ A + V +G+ +C ++H L+ +
Sbjct: 231 PKPVWVKWMR-GEQEQQGTQPGDILPNADETWYLRATLDVVAGEAAGLSCRVKHSSLEGQ 289
Query: 293 PLTLSWEPSSQPTIPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSS 338
+ L W S MG++A LAVL L L V +R++S
Sbjct: 290 DIVLYWGGS----YTSMGLIA-LAVLACLLFLLIVGFTSRFKRQTS 330
>gi|4502645 CD1B antigen precursor [Homo sapiens]
Length = 333
Score = 72.8 bits (177), Expect = 5e-13
Identities = 69/287 (24%), Positives = 128/287 (44%), Gaps = 26/287 (9%)
Query: 50 GYVDDTQFVRFDSDAASPRGEPRAPWVEQEGPEYWDRETQKYKRQAQADRVSLRNLRGYY 109
G++DD Q +DSD+ + A +++ W + K A+ + + + G+
Sbjct: 48 GWLDDLQIHGWDSDSGT------AIFLKP-----WSKGNFSDKEVAELEEIFRVYIFGFA 96
Query: 110 NQSEDGS--------HTLQRMSGCDLGPDGRLLRGYDQSAYDGKDYIALNED--LRSWTA 159
+ +D + +Q ++GC+L G ++ + + A G D++++ + S
Sbjct: 97 REVQDFAGDFQMKYPFEIQGIAGCELHSGGAIV-SFLRGALGGLDFLSVKNASCVPSPEG 155
Query: 160 ADTAAQITQRKLEAARAAEQLRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPL- 218
A + ++ E +R L TC +L L GK LQR P+ ++ P
Sbjct: 156 GSRAQKFCALIIQYQGIMETVRILLYETCPRYLLGVLNAGKADLQRQVKPEAWLSSGPSP 215
Query: 219 SDHEATLRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQE 278
L C GFYP + + W R GE + Q T+L + P + T+ A + V G+
Sbjct: 216 GPGRLQLVCHVSGFYPKPVWVMWMR-GEQEQQGTQLGDILPNANWTWYLRATLDVADGEA 274
Query: 279 QRYTCHMQHEGLQ-EPLTLSW-EPSSQPTIPIMGIVAGLAVLVVLAV 323
+C ++H L+ + + L W P+S +I + IV L +L+ LA+
Sbjct: 275 AGLSCRVKHSSLEGQDIILYWRNPTSIGSIVLAIIVPSLLLLLCLAL 321
>gi|239758095 PREDICTED: similar to major histocompatibility
complex, class II, DR beta 5 [Homo sapiens]
Length = 281
Score = 69.7 bits (169), Expect = 4e-12
Identities = 56/234 (23%), Positives = 99/234 (42%), Gaps = 26/234 (11%)
Query: 134 LRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAAR-------AAEQLRAYLEG 186
+R +S Y+ ++ + + D+ + A +T L AA E+ RA ++
Sbjct: 56 VRLVSRSIYNREEIVRFDSDVGEFRA------VTLLGLPAAEYWNSQKDILERKRAAVDR 109
Query: 187 TCVEWLRRYLENGKETLQRAEPPKTHVTHHPLS--DHEATLRCWALGFYPAEITLTWQRD 244
C Y + TLQR P ++ +H L C FYPA+I + W R+
Sbjct: 110 VC---RHNYQLELRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRN 166
Query: 245 GEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQP 304
G+++T GD TFQ + + + YTCH++H LQ P+T+ W S+
Sbjct: 167 GQEETAGVVSTPLIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSES 226
Query: 305 T-IPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGS-------CSQAAC 350
++ + G + ++ LG ++ + + GK G CS+ +C
Sbjct: 227 AQSKMLSGIGGFVLGLIFLGLGLIIHHRSQKGEEPQGKRGRWPVTQTLCSERSC 280
>gi|239740749 PREDICTED: similar to major histocompatibility
complex, class II, DR beta 5 [Homo sapiens]
Length = 281
Score = 69.7 bits (169), Expect = 4e-12
Identities = 56/234 (23%), Positives = 99/234 (42%), Gaps = 26/234 (11%)
Query: 134 LRGYDQSAYDGKDYIALNEDLRSWTAADTAAQITQRKLEAAR-------AAEQLRAYLEG 186
+R +S Y+ ++ + + D+ + A +T L AA E+ RA ++
Sbjct: 56 VRLVSRSIYNREEIVRFDSDVGEFRA------VTLLGLPAAEYWNSQKDILERKRAAVDR 109
Query: 187 TCVEWLRRYLENGKETLQRAEPPKTHVTHHPLS--DHEATLRCWALGFYPAEITLTWQRD 244
C Y + TLQR P ++ +H L C FYPA+I + W R+
Sbjct: 110 VC---RHNYQLELRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRN 166
Query: 245 GEDQTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQP 304
G+++T GD TFQ + + + YTCH++H LQ P+T+ W S+
Sbjct: 167 GQEETAGVVSTPLIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQSPITVEWRAQSES 226
Query: 305 T-IPIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGGS-------CSQAAC 350
++ + G + ++ LG ++ + + GK G CS+ +C
Sbjct: 227 AQSKMLSGIGGFVLGLIFLGLGLIIHHRSQKGEEPQGKRGRWPVTQTLCSERSC 280
>gi|239740918 PREDICTED: similar to major histocompatibility
complex, class II, DQ beta 1 isoform 1 [Homo sapiens]
Length = 281
Score = 69.3 bits (168), Expect = 5e-12
Identities = 55/227 (24%), Positives = 97/227 (42%), Gaps = 15/227 (6%)
Query: 134 LRGYDQSAYDGKDYIALNEDLRSWTAADT----AAQITQRKLEAARAAEQLRAYLEGTCV 189
+RG + Y+ ++Y + D+ + A AA+ + E E+ RA L+ C
Sbjct: 56 VRGVTRYIYNREEYARFDSDVGVYRAVTPLGPPAAEYWNSQKEVL---ERTRAELDTVC- 111
Query: 190 EWLRRYLENGKETLQRAEPPKTHVTHHPLS--DHEATLRCWALGFYPAEITLTWQRDGED 247
Y + TLQR P ++ +H L C FYPA+I + W R+ ++
Sbjct: 112 --RHNYQLELRTTLQRRVEPTVTISPSRTEALNHHNLLVCSVTDFYPAQIKVRWFRNDQE 169
Query: 248 QTQDTELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQPT-I 306
+T GD TFQ + + + YTCH++H LQ P+ + W S+
Sbjct: 170 ETTGVVSTPLIRNGDWTFQILVMLEMTPQRGDVYTCHVEHPSLQNPIIVEWRAQSESAQS 229
Query: 307 PIMGIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKGG--SCSQAACS 351
++ + G + ++ LG ++ + + GK G + +Q CS
Sbjct: 230 KMLSGIGGFVLGLIFLGLGLIIHHRSQKGEEPQGKRGRWAVTQTLCS 276
>gi|4504399 major histocompatibility complex, class II, DM beta
precursor [Homo sapiens]
Length = 263
Score = 67.4 bits (163), Expect = 2e-11
Identities = 36/122 (29%), Positives = 60/122 (49%), Gaps = 7/122 (5%)
Query: 205 RAEPPKTHVTHH-PLSDHEAT-LRCWALGFYPAEITLTWQRDGEDQTQDTELVET-RPAG 261
R PP V P + E L C+ GFYPAE+T+TW+++G+ + +T +P G
Sbjct: 111 RTRPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQPNG 170
Query: 262 DGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSWEPSSQP----TIPIMGIVAGLAV 317
D T+Q + + + YTC ++H G EP+ W P P + + + GL +
Sbjct: 171 DWTYQTLSHLALTPSYGDTYTCVVEHIGAPEPILRDWTPGLSPMQTLKVSVSAVTLGLGL 230
Query: 318 LV 319
++
Sbjct: 231 II 232
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.131 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,393,498
Number of Sequences: 37866
Number of extensions: 726089
Number of successful extensions: 2404
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 91
Number of HSP's successfully gapped in prelim test: 62
Number of HSP's that attempted gapping in prelim test: 2171
Number of HSP's gapped (non-prelim): 183
length of query: 366
length of database: 18,247,518
effective HSP length: 104
effective length of query: 262
effective length of database: 14,309,454
effective search space: 3749076948
effective search space used: 3749076948
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.