Guide to the Human Genome
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Search of human proteins with 51242945

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
         (780 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|51242945 striatin, calmodulin binding protein [Homo sapiens]      1564   0.0  
gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]             998   0.0  
gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]             783   0.0  
gi|89886480 zinedin isoform 2 [Homo sapiens]                          707   0.0  
gi|89886477 zinedin isoform 1 [Homo sapiens]                          707   0.0  
gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens]          119   8e-27
gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens]          119   8e-27
gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens]          117   4e-26
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]    84   5e-16
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]             83   1e-15
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]             83   1e-15
gi|148536855 coatomer protein complex, subunit alpha isoform 1 [...    80   7e-15
gi|148536853 coatomer protein complex, subunit alpha isoform 2 [...    80   7e-15
gi|4557741 platelet-activating factor acetylhydrolase, isoform I...    79   2e-14
gi|32189425 WD repeat domain 69 [Homo sapiens]                         79   2e-14
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s...    76   1e-13
gi|5174447 guanine nucleotide binding protein (G protein), beta ...    76   1e-13
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [...    74   7e-13
gi|26665869 WD repeat domain 51B [Homo sapiens]                        74   7e-13
gi|21071067 TBP-associated factor 5 [Homo sapiens]                     72   2e-12
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]          72   2e-12
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]          72   2e-12
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]          72   2e-12
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]            72   2e-12
gi|16554629 WD repeat domain 5 [Homo sapiens]                          72   3e-12
gi|16554627 WD repeat domain 5 [Homo sapiens]                          72   3e-12
gi|21536371 telomerase-associated protein 1 [Homo sapiens]             70   6e-12
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]     70   6e-12
gi|62234461 Notchless gene homolog isoform a [Homo sapiens]            70   7e-12
gi|13376840 WD repeat domain 61 [Homo sapiens]                         69   1e-11

>gi|51242945 striatin, calmodulin binding protein [Homo sapiens]
          Length = 780

 Score = 1564 bits (4049), Expect = 0.0
 Identities = 780/780 (100%), Positives = 780/780 (100%)

Query: 1   MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEW 60
           MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEW
Sbjct: 1   MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEW 60

Query: 61  ARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLK 120
           ARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLK
Sbjct: 61  ARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLK 120

Query: 121 YGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS 180
           YGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS
Sbjct: 121 YGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS 180

Query: 181 KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA 240
           KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA
Sbjct: 181 KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA 240

Query: 241 AADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNE 300
           AADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNE
Sbjct: 241 AADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNE 300

Query: 301 SRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN 360
           SRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN
Sbjct: 301 SRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN 360

Query: 361 LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE 420
           LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE
Sbjct: 361 LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE 420

Query: 421 LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT 480
           LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT
Sbjct: 421 LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT 480

Query: 481 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI 540
           ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI
Sbjct: 481 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI 540

Query: 541 QGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE 600
           QGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE
Sbjct: 541 QGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE 600

Query: 601 VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT 660
           VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT
Sbjct: 601 VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT 660

Query: 661 ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY 720
           ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY
Sbjct: 661 ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY 720

Query: 721 LMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV 780
           LMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV
Sbjct: 721 LMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV 780


>gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens]
          Length = 797

 Score =  998 bits (2580), Expect = 0.0
 Identities = 505/787 (64%), Positives = 616/787 (78%), Gaps = 18/787 (2%)

Query: 3   EQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWAR 62
           +Q GPG     +  G G A G GP A +  AG  A    +   QY++PGILH++QHEWAR
Sbjct: 20  QQQGPGGNLGLSPGGNGAAGGGGPPA-SEGAGPAAGPELSRPQQYTIPGILHYIQHEWAR 78

Query: 63  FEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 122
           FE+ERA WEVERAELQA+IAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG
Sbjct: 79  FEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 138

Query: 123 TELNQGDMKPPSYDSDEGNETEVQPQ-QNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSK 181
           TELNQGD+K P+++S+E  +TE     QNSQL WKQGRQLLRQYLQEVGYTDTILDV+S+
Sbjct: 139 TELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQ 198

Query: 182 RVRALLGFS-SDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA 240
           RVR+LLG S S+     + KN + ++NG E+  ++   I +S    S  VL+ F FLE+A
Sbjct: 199 RVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS----SGDVLETFNFLENA 254

Query: 241 AADFSDEDEDDDV-----DGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSE 295
             D SDEDE++D+     +G++K  ++   I  +    D  +D DT+EALKEFDFLVT+E
Sbjct: 255 --DDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAE 312

Query: 296 EGDN--ESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSK 353
           +G+   E+RS+GDGT+W+K+D     E W+VDQG+I+KLKEQYKKERKGKKGVKR NR+K
Sbjct: 313 DGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTK 372

Query: 354 LQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGA 413
           L DM+A+L D DELP +   + + SR +S+R+ +HE  RA+E E +TFP   GKSFIMG+
Sbjct: 373 LYDMIADLGD-DELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGS 431

Query: 414 DEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHP 473
           D+ L S LGLG+LA LTV N+AD  +YD+  NKDA RKTWNPK+TLRSHFDG+RALAFHP
Sbjct: 432 DDVLLSVLGLGDLADLTVTNDAD-YSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHP 490

Query: 474 IEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYS 533
           +EPVL+TASEDHTLK+WNLQKT PAKKS SLDVEPIYTFRAH GPVL + +SSNGEQC+S
Sbjct: 491 VEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFS 550

Query: 534 GGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTL 593
           GG D  IQ WN  +P++DPYD+Y+P+VL G L+GHTDAVWGLAYS    +LLSCSADGT+
Sbjct: 551 GGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTV 610

Query: 594 RLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTL 653
           RLWN  E  P +  +N  K+ GIP SVD +  DP+HMV SF+ G   I+++ET Q ++ L
Sbjct: 611 RLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVIL 670

Query: 654 ESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLA 713
            S VD+   S+  INRV+SHPTLP++ITAHEDRHIKF+DN TGK+IHSMVAHL+AVTSLA
Sbjct: 671 SSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLA 730

Query: 714 VDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGAD 773
           VDPNG+YLMSGSHDCSIRLWNL+SKTC+QE TAHRKK +ESI+DVAFH SK YIASAGAD
Sbjct: 731 VDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGAD 790

Query: 774 ALAKVFV 780
           ALAKVFV
Sbjct: 791 ALAKVFV 797


>gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens]
          Length = 713

 Score =  783 bits (2021), Expect = 0.0
 Identities = 422/780 (54%), Positives = 519/780 (66%), Gaps = 88/780 (11%)

Query: 3   EQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWAR 62
           +Q GPG     +  G G A G GP A +  AG  A    +   QY++PGILH++QHEWAR
Sbjct: 20  QQQGPGGNLGLSPGGNGAAGGGGPPA-SEGAGPAAGPELSRPQQYTIPGILHYIQHEWAR 78

Query: 63  FEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 122
           FE+ERA WEVERAELQA+IAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG
Sbjct: 79  FEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 138

Query: 123 TELNQGDMKPPSYDSDEGNETEVQPQ-QNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSK 181
           TELNQGD+K P+++S+E  +TE     QNSQL WKQGRQLLRQYLQEVGYT         
Sbjct: 139 TELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYT--------- 189

Query: 182 RVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAA 241
                                D++++     V+    ++ SE   S    +  + L    
Sbjct: 190 ---------------------DTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGG- 227

Query: 242 ADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNES 301
                  E     G+E                     R + + L+ F+FL  +++ D + 
Sbjct: 228 -------ESPKQKGQEIK-------------------RSSGDVLETFNFLENADDSDED- 260

Query: 302 RSAGDGTDWEKEDQCL-MPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN 360
                    E+ D    +PE          K K +  K + G +G+   + +   D    
Sbjct: 261 ---------EENDMIEGIPEG---------KDKHRMNKHKIGNEGLAA-DLTDDPDTEEA 301

Query: 361 LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE 420
           L++ D L + +   G+    SS        +  +  E +TFP   GKSFIMG+D+ L S 
Sbjct: 302 LKEFDFLVTAEDGEGAGEARSSG-------DGTEWAEPITFPSGGGKSFIMGSDDVLLSV 354

Query: 421 LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT 480
           LGLG+LA LTV N+AD  +YD+  NKDA RKTWNPK+TLRSHFDG+RALAFHP+EPVL+T
Sbjct: 355 LGLGDLADLTVTNDAD-YSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVT 413

Query: 481 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI 540
           ASEDHTLK+WNLQKT PAKKS SLDVEPIYTFRAH GPVL + +SSNGEQC+SGG D  I
Sbjct: 414 ASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATI 473

Query: 541 QGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE 600
           Q WN  +P++DPYD+Y+P+VL G L+GHTDAVWGLAYS    +LLSCSADGT+RLWN  E
Sbjct: 474 QWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQE 533

Query: 601 VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT 660
             P +  +N  K+ GIP SVD +  DP+HMV SF+ G   I+++ET Q ++ L S VD+ 
Sbjct: 534 KLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSG 593

Query: 661 ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY 720
             S+  INRV+SHPTLP++ITAHEDRHIKF+DN TGK+IHSMVAHL+AVTSLAVDPNG+Y
Sbjct: 594 LQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIY 653

Query: 721 LMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV 780
           LMSGSHDCSIRLWNL+SKTC+QE TAHRKK +ESI+DVAFH SK YIASAGADALAKVFV
Sbjct: 654 LMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713


>gi|89886480 zinedin isoform 2 [Homo sapiens]
          Length = 760

 Score =  707 bits (1826), Expect = 0.0
 Identities = 397/795 (49%), Positives = 502/795 (63%), Gaps = 77/795 (9%)

Query: 5   AGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFE 64
           AGPG   +   P +  A G GP  +    G G+    A     SLPGILHF+QHEWARFE
Sbjct: 24  AGPGP--TGAAPVSAPAPGPGPAGKGGGGG-GSPGPTAGPEPLSLPGILHFIQHEWARFE 80

Query: 65  VERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTE 124
            E+A+WE ERAELQAQ+AFLQGERKGQENLK DLVRRIKMLEYALKQERAKYHKLK+GT+
Sbjct: 81  AEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTD 140

Query: 125 LNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVR 184
           LNQG+ K    +       E    +NS L+WK+GRQLLRQYL+EVGYTDTILD++SKRVR
Sbjct: 141 LNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVR 200

Query: 185 ALLGFSSDVTDREDDKN---------------QDSVVNGTEAEVKETAMIAKSELTDSAS 229
           +LLG S ++    +                  +  +V   E ++K  A     +     S
Sbjct: 201 SLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGS 260

Query: 230 VLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFD 289
           VL    FL++   + SDED++ D    +K  +   +      + D  E+ D+++A+ EFD
Sbjct: 261 VLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320

Query: 290 FLVTSEEGD---NESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGV 346
           FL + E+G+   +  R   DG+  E E +                               
Sbjct: 321 FLGSGEDGEGAPDPRRCTVDGSPHELESR------------------------------- 349

Query: 347 KRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSG 406
               R KLQ +LA+LRDVD LP   P V  P  P + +   HE +             S 
Sbjct: 350 ----RVKLQGILADLRDVDGLP---PKVTGPP-PGTPQPRPHEGSFG----------FSS 391

Query: 407 KSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGI 466
             FIM  D     E+ LG+LA LTV N+ D L+ D++++KDA +KTWNPKFTLRSH+DGI
Sbjct: 392 DVFIM--DTIGGGEVSLGDLADLTVTNDND-LSCDLSDSKDAFKKTWNPKFTLRSHYDGI 448

Query: 467 RALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSS 526
           R+LAFH  +  L+TASED TLK+WNLQK   AKK+ +LDVEPI+ FRAH+GPVL V M S
Sbjct: 449 RSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGS 508

Query: 527 NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLS 586
           N E CYSGG D  I  W   + ++DPYD YDPSVL   L GH DAVWGLA+S   QRL S
Sbjct: 509 NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLAS 568

Query: 587 CSADGTLRLWNTTEVAPA-LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME 645
           CSADGT+R+W+ +  +PA L  F    E G+P SV   S++P+H+VASF  G T +++ME
Sbjct: 569 CSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDME 628

Query: 646 TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAH 705
               +LTLES     ++   QIN+V+SHP  P++ITAH+DR I+F DN TGK +HSMVAH
Sbjct: 629 VGSALLTLESR---GSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAH 685

Query: 706 LEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKC 765
           L+AVT LAVDPNG +LMSGSHDCS+RLW+L++KTC+QE TAHRKK EE+IH VA HPSK 
Sbjct: 686 LDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKA 745

Query: 766 YIASAGADALAKVFV 780
            IASAGADALAKVFV
Sbjct: 746 LIASAGADALAKVFV 760


>gi|89886477 zinedin isoform 1 [Homo sapiens]
          Length = 753

 Score =  707 bits (1826), Expect = 0.0
 Identities = 394/795 (49%), Positives = 499/795 (62%), Gaps = 84/795 (10%)

Query: 5   AGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFE 64
           AGPG   +   P +  A G GP  +    G G+    A     SLPGILHF+QHEWARFE
Sbjct: 24  AGPGP--TGAAPVSAPAPGPGPAGKGGGGG-GSPGPTAGPEPLSLPGILHFIQHEWARFE 80

Query: 65  VERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTE 124
            E+A+WE ERAELQAQ+AFLQGERKGQENLK DLVRRIKMLEYALKQERAKYHKLK+GT+
Sbjct: 81  AEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTD 140

Query: 125 LNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVR 184
           LNQG+ K    +       E    +NS L+WK+GRQLLRQYL+EVGYTDTILD++SKRVR
Sbjct: 141 LNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVR 200

Query: 185 ALLGFSSDVTDREDDKN---------------QDSVVNGTEAEVKETAMIAKSELTDSAS 229
           +LLG S ++    +                  +  +V   E ++K  A     +     S
Sbjct: 201 SLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGS 260

Query: 230 VLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFD 289
           VL    FL++   + SDED++ D    +K  +   +      + D  E+ D+++A+ EFD
Sbjct: 261 VLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320

Query: 290 FLVTSEEGD---NESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGV 346
           FL + E+G+   +  R   DG+  E E +                               
Sbjct: 321 FLGSGEDGEGAPDPRRCTVDGSPHELESR------------------------------- 349

Query: 347 KRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSG 406
               R KLQ +LA+LRDVD LP   P V  P   +    P  ++                
Sbjct: 350 ----RVKLQGILADLRDVDGLP---PKVTGPPPGTPQPRPHEDV---------------- 386

Query: 407 KSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGI 466
             FIM  D     E+ LG+LA LTV N+ D L+ D++++KDA +KTWNPKFTLRSH+DGI
Sbjct: 387 --FIM--DTIGGGEVSLGDLADLTVTNDND-LSCDLSDSKDAFKKTWNPKFTLRSHYDGI 441

Query: 467 RALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSS 526
           R+LAFH  +  L+TASED TLK+WNLQK   AKK+ +LDVEPI+ FRAH+GPVL V M S
Sbjct: 442 RSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGS 501

Query: 527 NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLS 586
           N E CYSGG D  I  W   + ++DPYD YDPSVL   L GH DAVWGLA+S   QRL S
Sbjct: 502 NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLAS 561

Query: 587 CSADGTLRLWNTTEVAPA-LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME 645
           CSADGT+R+W+ +  +PA L  F    E G+P SV   S++P+H+VASF  G T +++ME
Sbjct: 562 CSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDME 621

Query: 646 TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAH 705
               +LTLES     ++   QIN+V+SHP  P++ITAH+DR I+F DN TGK +HSMVAH
Sbjct: 622 VGSALLTLESR---GSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAH 678

Query: 706 LEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKC 765
           L+AVT LAVDPNG +LMSGSHDCS+RLW+L++KTC+QE TAHRKK EE+IH VA HPSK 
Sbjct: 679 LDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKA 738

Query: 766 YIASAGADALAKVFV 780
            IASAGADALAKVFV
Sbjct: 739 LIASAGADALAKVFV 753


>gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens]
          Length = 127

 Score =  119 bits (299), Expect = 8e-27
 Identities = 61/79 (77%), Positives = 66/79 (83%), Gaps = 1/79 (1%)

Query: 60  WARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKL 119
           W   EV+ AQ   +    +AQIAFLQGERK QENLKKDLVR+IKMLEYALKQ+RAKYHKL
Sbjct: 10  WETGEVQ-AQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYHKL 68

Query: 120 KYGTELNQGDMKPPSYDSD 138
           KYG ELNQGDMKPPSYDSD
Sbjct: 69  KYGRELNQGDMKPPSYDSD 87


>gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens]
          Length = 127

 Score =  119 bits (299), Expect = 8e-27
 Identities = 61/79 (77%), Positives = 66/79 (83%), Gaps = 1/79 (1%)

Query: 60  WARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKL 119
           W   EV+ AQ   +    +AQIAFLQGERK QENLKKDLVR+IKMLEYALKQ+RAKYHKL
Sbjct: 10  WETGEVQ-AQSATKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYHKL 68

Query: 120 KYGTELNQGDMKPPSYDSD 138
           KYG ELNQGDMKPPSYDSD
Sbjct: 69  KYGRELNQGDMKPPSYDSD 87


>gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens]
          Length = 127

 Score =  117 bits (293), Expect = 4e-26
 Identities = 60/79 (75%), Positives = 65/79 (82%), Gaps = 1/79 (1%)

Query: 60  WARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKL 119
           W   EV+ AQ   +    +AQIAFLQGERK QENLKKDLVR+IKMLEYALKQ+RAKYHKL
Sbjct: 10  WETGEVQ-AQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYHKL 68

Query: 120 KYGTELNQGDMKPPSYDSD 138
           KYG ELNQGDMKPP YDSD
Sbjct: 69  KYGRELNQGDMKPPIYDSD 87


>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
          Length = 357

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 71/278 (25%), Positives = 114/278 (41%), Gaps = 29/278 (10%)

Query: 508 PIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLG 567
           PI     H+G V C     NG    S G D LI  WN         D+Y        L G
Sbjct: 58  PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD----CDNY------ATLKG 107

Query: 568 HTDAVWGLAYSAAHQRLLSCSADGTLRLWN--TTEVAPALSVFNDTKELGIPASVDLVSS 625
           H+ AV  L Y+     L S S D T+ +W+  T E    L           PA       
Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR-----R 162

Query: 626 DPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHED 685
            P  +      G   ++++  +  I T ++          Q+  V  + T    I+   D
Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTY--------QVLAVTFNDTSDQIISGGID 214

Query: 686 RHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLE----SKTCI 741
             IK +D    KL ++M  H ++VT L++   G YL+S + D ++R+W++      + C+
Sbjct: 215 NDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCV 274

Query: 742 QEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
           + F  +   FE+++   ++ P    IA+  AD    V+
Sbjct: 275 KIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 29/137 (21%), Positives = 63/137 (45%), Gaps = 14/137 (10%)

Query: 457 FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHK 516
           +T+R H D +  L+       L++ + D+T+++W+++  AP ++   +    ++ F  + 
Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN- 287

Query: 517 GPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLA 576
             +L    S +G +  +G  D  +  W+TT+  I              L GH  ++  +A
Sbjct: 288 --LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRI-----------LYKLPGHAGSINEVA 334

Query: 577 YSAAHQRLLSCSADGTL 593
           +      ++S S+D  L
Sbjct: 335 FHPDEPIIISASSDKRL 351



 Score = 35.8 bits (81), Expect = 0.16
 Identities = 16/37 (43%), Positives = 22/37 (59%)

Query: 457 FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQ 493
           + L  H   I  +AFHP EP++I+AS D  L M  +Q
Sbjct: 321 YKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357


>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
          Length = 359

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 66/283 (23%), Positives = 123/283 (43%), Gaps = 30/283 (10%)

Query: 496 APAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS 555
           AP  +  SL+      F+ H+  V CV  S N +Q  SG  D  +  W+           
Sbjct: 3   APCAEDPSLERH----FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK--------- 49

Query: 556 YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELG 615
             P        GH DAV  + +S +   L S S D T+R+W    V    +VF       
Sbjct: 50  --PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFR--AHTA 104

Query: 616 IPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPT 675
              SV   S   S + AS  K    ++    Q+ + +L  +++    +          P 
Sbjct: 105 TVRSVHFCSDGQSFVTASDDKT-VKVWATHRQKFLFSLSQHINWVRCAKFS-------PD 156

Query: 676 LPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL 735
             + ++A +D+ +K +D ++ + +HS   H   VT +   P+G  + +   D ++++W++
Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216

Query: 736 ESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKV 778
            +   +Q +  H      +++ ++FHPS  Y+ +A +D+  K+
Sbjct: 217 RTHRLLQHYQLH----SAAVNGLSFHPSGNYLITASSDSTLKI 255



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 72/324 (22%), Positives = 124/324 (38%), Gaps = 45/324 (13%)

Query: 460 RSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPV 519
           + H D +  + F      L + S D  L +W+++  + A           Y F  HK  V
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA-----------YRFTGHKDAV 64

Query: 520 LCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSA 579
            CV  S +G    SG  D  ++ W    PN+      + +V R     HT  V  + + +
Sbjct: 65  TCVNFSPSGHLLASGSRDKTVRIWV---PNVKG----ESTVFRA----HTATVRSVHFCS 113

Query: 580 AHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYT 639
             Q  ++ S D T+++W T       S+      +                 A FS    
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV---------------RCAKFSPDGR 158

Query: 640 SIFNMETQQRILTLESNVDTTANSSCQ----INRVISHPTLPISITAHEDRHIKFYDNNT 695
            I +    + +   + +     +S C+    +  V  HP+      A  D  +K +D  T
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218

Query: 696 GKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESI 755
            +L+     H  AV  L+  P+G YL++ S D ++++ +L     +     H    +   
Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPA 274

Query: 756 HDVAFHPSKCYIASAGADALAKVF 779
             VAF  +  Y AS G+D    V+
Sbjct: 275 TTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 60/227 (26%), Positives = 105/227 (46%), Gaps = 24/227 (10%)

Query: 557 DPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGI 616
           DPS+ R    GH DAV  + +S   ++L S S D  L +W+   + P    +  T   G 
Sbjct: 8   DPSLERH-FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWH---MKPQSRAYRFT---GH 60

Query: 617 PASVDLVSSDPS-HMVASFSKGYTS---IFNMETQQRILTLESNVDTTANSSCQINRVIS 672
             +V  V+  PS H++AS S+  T    + N++ +  +    +    + +  C   +   
Sbjct: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CSDGQSF- 118

Query: 673 HPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRL 732
                  +TA +D+ +K +  +  K + S+  H+  V      P+G  ++S S D +++L
Sbjct: 119 -------VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKL 171

Query: 733 WNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
           W+  S+ C+  +  H       +  V FHPS   IA+AG D   KV+
Sbjct: 172 WDKSSRECVHSYCEH----GGFVTYVDFHPSGTCIAAAGMDNTVKVW 214



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 64/296 (21%), Positives = 115/296 (38%), Gaps = 38/296 (12%)

Query: 443 ANNKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAP 497
           + + D+    W+ K     +    H D +  + F P   +L + S D T+++W      P
Sbjct: 36  SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VP 90

Query: 498 AKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYD 557
             K  S        FRAH   V  V   S+G+   +   D  ++ W T            
Sbjct: 91  NVKGEST------VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF------- 137

Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIP 617
                  L  H + V    +S   + ++S S D T++LW+ +       V +  +  G  
Sbjct: 138 ----LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE---CVHSYCEHGGFV 190

Query: 618 ASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLP 677
             VD   S    + A+       ++++ T + +   + +       S  +N +  HP+  
Sbjct: 191 TYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLH-------SAAVNGLSFHPSGN 242

Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLW 733
             ITA  D  +K  D   G+L++++  H    T++A    G Y  SG  D  + +W
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 38/123 (30%), Positives = 54/123 (43%), Gaps = 14/123 (11%)

Query: 462 HFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLC 521
           H   +  L+FHP    LITAS D TLK+ +L           ++   +YT   H+GP   
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDL-----------MEGRLLYTLHGHQGPATT 276

Query: 522 VVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAH 581
           V  S  GE   SGG+D  +  W +   N D  D  + + +  P      ++  L  S   
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKS---NFDIVDHGEVTKVPRPPATLASSMGNLTVSILE 333

Query: 582 QRL 584
           QRL
Sbjct: 334 QRL 336


>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
          Length = 407

 Score = 82.8 bits (203), Expect = 1e-15
 Identities = 66/283 (23%), Positives = 123/283 (43%), Gaps = 30/283 (10%)

Query: 496 APAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS 555
           AP  +  SL+      F+ H+  V CV  S N +Q  SG  D  +  W+           
Sbjct: 3   APCAEDPSLERH----FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK--------- 49

Query: 556 YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELG 615
             P        GH DAV  + +S +   L S S D T+R+W    V    +VF       
Sbjct: 50  --PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFR--AHTA 104

Query: 616 IPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPT 675
              SV   S   S + AS  K    ++    Q+ + +L  +++    +          P 
Sbjct: 105 TVRSVHFCSDGQSFVTASDDKT-VKVWATHRQKFLFSLSQHINWVRCAKFS-------PD 156

Query: 676 LPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL 735
             + ++A +D+ +K +D ++ + +HS   H   VT +   P+G  + +   D ++++W++
Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216

Query: 736 ESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKV 778
            +   +Q +  H      +++ ++FHPS  Y+ +A +D+  K+
Sbjct: 217 RTHRLLQHYQLH----SAAVNGLSFHPSGNYLITASSDSTLKI 255



 Score = 68.9 bits (167), Expect = 2e-11
 Identities = 72/324 (22%), Positives = 124/324 (38%), Gaps = 45/324 (13%)

Query: 460 RSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPV 519
           + H D +  + F      L + S D  L +W+++  + A           Y F  HK  V
Sbjct: 16  KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA-----------YRFTGHKDAV 64

Query: 520 LCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSA 579
            CV  S +G    SG  D  ++ W    PN+      + +V R     HT  V  + + +
Sbjct: 65  TCVNFSPSGHLLASGSRDKTVRIWV---PNVKG----ESTVFRA----HTATVRSVHFCS 113

Query: 580 AHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYT 639
             Q  ++ S D T+++W T       S+      +                 A FS    
Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV---------------RCAKFSPDGR 158

Query: 640 SIFNMETQQRILTLESNVDTTANSSCQ----INRVISHPTLPISITAHEDRHIKFYDNNT 695
            I +    + +   + +     +S C+    +  V  HP+      A  D  +K +D  T
Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218

Query: 696 GKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESI 755
            +L+     H  AV  L+  P+G YL++ S D ++++ +L     +     H    +   
Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPA 274

Query: 756 HDVAFHPSKCYIASAGADALAKVF 779
             VAF  +  Y AS G+D    V+
Sbjct: 275 TTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 60/227 (26%), Positives = 105/227 (46%), Gaps = 24/227 (10%)

Query: 557 DPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGI 616
           DPS+ R    GH DAV  + +S   ++L S S D  L +W+   + P    +  T   G 
Sbjct: 8   DPSLERH-FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWH---MKPQSRAYRFT---GH 60

Query: 617 PASVDLVSSDPS-HMVASFSKGYTS---IFNMETQQRILTLESNVDTTANSSCQINRVIS 672
             +V  V+  PS H++AS S+  T    + N++ +  +    +    + +  C   +   
Sbjct: 61  KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CSDGQSF- 118

Query: 673 HPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRL 732
                  +TA +D+ +K +  +  K + S+  H+  V      P+G  ++S S D +++L
Sbjct: 119 -------VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKL 171

Query: 733 WNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
           W+  S+ C+  +  H       +  V FHPS   IA+AG D   KV+
Sbjct: 172 WDKSSRECVHSYCEH----GGFVTYVDFHPSGTCIAAAGMDNTVKVW 214



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 64/296 (21%), Positives = 115/296 (38%), Gaps = 38/296 (12%)

Query: 443 ANNKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAP 497
           + + D+    W+ K     +    H D +  + F P   +L + S D T+++W      P
Sbjct: 36  SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VP 90

Query: 498 AKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYD 557
             K  S        FRAH   V  V   S+G+   +   D  ++ W T            
Sbjct: 91  NVKGEST------VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF------- 137

Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIP 617
                  L  H + V    +S   + ++S S D T++LW+ +       V +  +  G  
Sbjct: 138 ----LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE---CVHSYCEHGGFV 190

Query: 618 ASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLP 677
             VD   S    + A+       ++++ T + +   + +       S  +N +  HP+  
Sbjct: 191 TYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLH-------SAAVNGLSFHPSGN 242

Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLW 733
             ITA  D  +K  D   G+L++++  H    T++A    G Y  SG  D  + +W
Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298



 Score = 53.1 bits (126), Expect = 9e-07
 Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 11/90 (12%)

Query: 462 HFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLC 521
           H   +  L+FHP    LITAS D TLK+ +L           ++   +YT   H+GP   
Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDL-----------MEGRLLYTLHGHQGPATT 276

Query: 522 VVMSSNGEQCYSGGTDGLIQGWNTTNPNID 551
           V  S  GE   SGG+D  +  W +    +D
Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKSNFDIVD 306


>gi|148536855 coatomer protein complex, subunit alpha isoform 1
           [Homo sapiens]
          Length = 1233

 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 79/338 (23%), Positives = 136/338 (40%), Gaps = 56/338 (16%)

Query: 466 IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMS 525
           ++ L+FHP  P ++T+  +  +++W+ +      K           F  H GPV  +   
Sbjct: 12  VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60

Query: 526 SNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLL 585
                  SGG D  I+ WN           Y        LLGH D +    +   +  +L
Sbjct: 61  KQQPLFVSGGDDYKIKVWN-----------YKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109

Query: 586 SCSADGTLRLWNTTEVAPALSV-----------FNDTKELGIPASVDLVSSDPSHMVASF 634
           S S D T+R+WN         +           F+ T++L + AS+D   +     ++  
Sbjct: 110 SASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLD--QTVRVWDISGL 167

Query: 635 SKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVIS-----------HPTLPISITAH 683
            K   S   +E+  R +T    VD    +   +  V+            HPT+P+ ++  
Sbjct: 168 RKKNLSPGAVESDVRGIT---GVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGA 224

Query: 684 EDRHIKFYDNNTGKL--IHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCI 741
           +DR +K +  N  K   + +   H   V+     P    ++S S D SIR+W++  +T +
Sbjct: 225 DDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGV 284

Query: 742 QEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
           Q F     +F      +A HP+   + +AG D    VF
Sbjct: 285 QTFRRDHDRF----WVLAAHPN-LNLFAAGHDGGMIVF 317



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 65/317 (20%), Positives = 111/317 (35%), Gaps = 85/317 (26%)

Query: 442 IANNKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTA 496
           ++   D   K WN K     FTL  H D IR   FH   P +++AS+D T+++WN Q   
Sbjct: 67  VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126

Query: 497 PAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTT---NPNIDP- 552
                       +     H   V+C       +   S   D  ++ W+ +     N+ P 
Sbjct: 127 -----------CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175

Query: 553 -YDSYDPSVLRGPLLGHTDAV---------WGLAYSAAHQR---LLSCSADGTLRLWNTT 599
             +S    +    L G TDAV          G+ ++A H     ++S + D  +++W   
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235

Query: 600 EVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDT 659
           E                                  SK +                  VDT
Sbjct: 236 E----------------------------------SKAW-----------------EVDT 244

Query: 660 TANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGL 719
                  ++  + HP   + ++  ED+ I+ +D +    + +     +    LA  PN L
Sbjct: 245 CRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPN-L 303

Query: 720 YLMSGSHDCSIRLWNLE 736
            L +  HD  + ++ LE
Sbjct: 304 NLFAAGHDGGMIVFKLE 320



 Score = 37.4 bits (85), Expect = 0.054
 Identities = 27/116 (23%), Positives = 46/116 (39%), Gaps = 4/116 (3%)

Query: 664 SCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMS 723
           S ++  +  HP  P  +T+  +  I+ +D     LI     H   V  +         +S
Sbjct: 9   SARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVS 68

Query: 724 GSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
           G  D  I++WN + + C+     H     + I    FH    +I SA  D   +V+
Sbjct: 69  GGDDYKIKVWNYKLRRCLFTLLGHL----DYIRTTFFHHEYPWILSASDDQTIRVW 120


>gi|148536853 coatomer protein complex, subunit alpha isoform 2
           [Homo sapiens]
          Length = 1224

 Score = 80.1 bits (196), Expect = 7e-15
 Identities = 79/338 (23%), Positives = 136/338 (40%), Gaps = 56/338 (16%)

Query: 466 IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMS 525
           ++ L+FHP  P ++T+  +  +++W+ +      K           F  H GPV  +   
Sbjct: 12  VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60

Query: 526 SNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLL 585
                  SGG D  I+ WN           Y        LLGH D +    +   +  +L
Sbjct: 61  KQQPLFVSGGDDYKIKVWN-----------YKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109

Query: 586 SCSADGTLRLWNTTEVAPALSV-----------FNDTKELGIPASVDLVSSDPSHMVASF 634
           S S D T+R+WN         +           F+ T++L + AS+D   +     ++  
Sbjct: 110 SASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLD--QTVRVWDISGL 167

Query: 635 SKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVIS-----------HPTLPISITAH 683
            K   S   +E+  R +T    VD    +   +  V+            HPT+P+ ++  
Sbjct: 168 RKKNLSPGAVESDVRGIT---GVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGA 224

Query: 684 EDRHIKFYDNNTGKL--IHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCI 741
           +DR +K +  N  K   + +   H   V+     P    ++S S D SIR+W++  +T +
Sbjct: 225 DDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGV 284

Query: 742 QEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
           Q F     +F      +A HP+   + +AG D    VF
Sbjct: 285 QTFRRDHDRF----WVLAAHPN-LNLFAAGHDGGMIVF 317



 Score = 50.1 bits (118), Expect = 8e-06
 Identities = 65/317 (20%), Positives = 111/317 (35%), Gaps = 85/317 (26%)

Query: 442 IANNKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTA 496
           ++   D   K WN K     FTL  H D IR   FH   P +++AS+D T+++WN Q   
Sbjct: 67  VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126

Query: 497 PAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTT---NPNIDP- 552
                       +     H   V+C       +   S   D  ++ W+ +     N+ P 
Sbjct: 127 -----------CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175

Query: 553 -YDSYDPSVLRGPLLGHTDAV---------WGLAYSAAHQR---LLSCSADGTLRLWNTT 599
             +S    +    L G TDAV          G+ ++A H     ++S + D  +++W   
Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235

Query: 600 EVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDT 659
           E                                  SK +                  VDT
Sbjct: 236 E----------------------------------SKAW-----------------EVDT 244

Query: 660 TANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGL 719
                  ++  + HP   + ++  ED+ I+ +D +    + +     +    LA  PN L
Sbjct: 245 CRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPN-L 303

Query: 720 YLMSGSHDCSIRLWNLE 736
            L +  HD  + ++ LE
Sbjct: 304 NLFAAGHDGGMIVFKLE 320



 Score = 37.4 bits (85), Expect = 0.054
 Identities = 27/116 (23%), Positives = 46/116 (39%), Gaps = 4/116 (3%)

Query: 664 SCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMS 723
           S ++  +  HP  P  +T+  +  I+ +D     LI     H   V  +         +S
Sbjct: 9   SARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVS 68

Query: 724 GSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
           G  D  I++WN + + C+     H     + I    FH    +I SA  D   +V+
Sbjct: 69  GGDDYKIKVWNYKLRRCLFTLLGHL----DYIRTTFFHHEYPWILSASDDQTIRVW 120


>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
           alpha subunit [Homo sapiens]
          Length = 410

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 78/348 (22%), Positives = 144/348 (41%), Gaps = 51/348 (14%)

Query: 451 KTWNP----KFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDV 506
           K W P    K+ L  H   +  + FHP+  V+++ASED T+K+W+ +         + D 
Sbjct: 92  KEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYE---------TGDF 142

Query: 507 EPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLL 566
           E   T + H   V  +    +G+   S   D  I+ W          D      +R  + 
Sbjct: 143 E--RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW----------DFQGFECIR-TMH 189

Query: 567 GHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLV-SS 625
           GH   V  +A       ++S S D T+++W   +    +  F   +E      V +V  +
Sbjct: 190 GHDHNVSSVAIMPNGDHIVSASRDKTIKMWE-VQTGYCVKTFTGHREW-----VRMVRPN 243

Query: 626 DPSHMVASFSKGYT----SIFNMETQQRILTLESNVDTTA----NSSCQINRVISHPTL- 676
               ++AS S   T     +   E +  +   E  V+  +    +S   I+      T  
Sbjct: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKK 303

Query: 677 -----PISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIR 731
                P  ++   D+ IK +D +TG  + ++V H   V  +     G +++S + D ++R
Sbjct: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363

Query: 732 LWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
           +W+ ++K C++   AH    E  +  + FH +  Y+ +   D   KV+
Sbjct: 364 VWDYKNKRCMKTLNAH----EHFVTSLDFHKTAPYVVTGSVDQTVKVW 407


>gi|32189425 WD repeat domain 69 [Homo sapiens]
          Length = 415

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 61/277 (22%), Positives = 120/277 (43%), Gaps = 35/277 (12%)

Query: 458 TLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKG 517
           T R H   I  L+F+P   ++ T S D T K+W++Q             E +YT R H  
Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG-----------EEVYTLRGHSA 220

Query: 518 PVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAY 577
            ++ +  +++G++  +G  D  +  W+            D       L+GH   +   ++
Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDA-----------DTGRKVNILIGHCAEISSASF 269

Query: 578 SAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSK- 636
           +     +L+ S D T +LW+ T      ++     E+     +D        ++A+ S  
Sbjct: 270 NWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI-----LDSCFDYTGKLIATASAD 324

Query: 637 GYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTG 696
           G   IF+  T++ I  LE +         +I+++  +P     +T   D+  + +D  TG
Sbjct: 325 GTARIFSAATRKCIAKLEGHEG-------EISKISFNPQGNHLLTGSSDKTARIWDAQTG 377

Query: 697 KLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLW 733
           + +  +  H + + S A +  G  +++GS D + R+W
Sbjct: 378 QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414



 Score = 67.4 bits (163), Expect = 5e-11
 Identities = 65/305 (21%), Positives = 138/305 (45%), Gaps = 31/305 (10%)

Query: 478 LITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTD 537
           L+TAS    +K+   +      ++++         +AH  P+  V ++ +G    +G  D
Sbjct: 54  LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYD 113

Query: 538 GLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAH-QRLLSCSADGTLRLW 596
              + W+T +                 L GH + V+ +A++  +  ++ + S D T +LW
Sbjct: 114 RTCKLWDTASGEE-----------LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162

Query: 597 NTTEVAPALSVFNDTKELGIPASVDLVSSDP-SHMVASFSKGYTS-IFNMETQQRILTLE 654
           +  E       F      G  A +  +S +P S +VA+ S   T+ +++++  + + TL 
Sbjct: 163 SV-ETGKCYHTFR-----GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216

Query: 655 SNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAV 714
            +       S +I  +  + +    IT   D  +  +D +TG+ ++ ++ H   ++S + 
Sbjct: 217 GH-------SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASF 269

Query: 715 DPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADA 774
           + +   +++GS D + +LW+  +  C+   T H    ++ I D  F  +   IA+A AD 
Sbjct: 270 NWDCSLILTGSMDKTCKLWDATNGKCVATLTGH----DDEILDSCFDYTGKLIATASADG 325

Query: 775 LAKVF 779
            A++F
Sbjct: 326 TARIF 330



 Score = 66.6 bits (161), Expect = 8e-11
 Identities = 62/323 (19%), Positives = 131/323 (40%), Gaps = 38/323 (11%)

Query: 458 TLRSHFDGIRALAFH-PIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHK 516
           TL  H + + A+AF+ P    + T S D T K+W+++             +  +TFR H 
Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG-----------KCYHTFRGHT 177

Query: 517 GPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLA 576
             ++C+  +       +G  D   + W+  N      + Y        L GH+  +  L+
Sbjct: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE----EVYT-------LRGHSAEIISLS 226

Query: 577 YSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSK 636
           ++ +  R+++ S D T+ +W+         +     E+   +     + D S ++     
Sbjct: 227 FNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS----FNWDCSLILTGSMD 282

Query: 637 GYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTG 696
               +++    + + TL  + D   +S           T  +  TA  D   + +   T 
Sbjct: 283 KTCKLWDATNGKCVATLTGHDDEILDSCFDY-------TGKLIATASADGTARIFSAATR 335

Query: 697 KLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIH 756
           K I  +  H   ++ ++ +P G +L++GS D + R+W+ ++  C+Q    H     + I 
Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGH----TDEIF 391

Query: 757 DVAFHPSKCYIASAGADALAKVF 779
             AF+     + +   D   +++
Sbjct: 392 SCAFNYKGNIVITGSKDNTCRIW 414



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 72/398 (18%), Positives = 157/398 (39%), Gaps = 51/398 (12%)

Query: 387 EHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNK 446
           +H   +   ++ L   PS+  S       AL  E+   E   L  A+  + +   I   +
Sbjct: 21  KHGELKTKSIDLLDLGPSTDVS-------ALVEEIQKAE--PLLTASRTEQVKLLIQRLQ 71

Query: 447 DALRKTWNPKF----TLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKST 502
           + L +  N  F     L++H   +  +A +      IT S D T K+W+           
Sbjct: 72  EKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD----------- 120

Query: 503 SLDVEPIYTFRAHKGPVLCVVMSS-NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVL 561
           +   E + T   H+  V  +  ++  G++  +G  D   + W           S +    
Sbjct: 121 TASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW-----------SVETGKC 169

Query: 562 RGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVD 621
                GHT  +  L+++     + + S D T +LW+        ++   + E+    S+ 
Sbjct: 170 YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEI---ISLS 226

Query: 622 LVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISIT 681
             +S    +  SF      +++ +T +++  L  +    +++S   +         + +T
Sbjct: 227 FNTSGDRIITGSFDHTVV-VWDADTGRKVNILIGHCAEISSASFNWD-------CSLILT 278

Query: 682 AHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCI 741
              D+  K +D   GK + ++  H + +     D  G  + + S D + R+++  ++ CI
Sbjct: 279 GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCI 338

Query: 742 QEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
            +   H    E  I  ++F+P   ++ +  +D  A+++
Sbjct: 339 AKLEGH----EGEISKISFNPQGNHLLTGSSDKTARIW 372



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 50/229 (21%), Positives = 90/229 (39%), Gaps = 37/229 (16%)

Query: 447 DALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKS 501
           D   K W+ +     +TLR H   I +L+F+     +IT S DHT+ +W+    A   + 
Sbjct: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD----ADTGRK 253

Query: 502 TSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVL 561
            ++ +        H   +     + +     +G  D   + W+ TN              
Sbjct: 254 VNILI-------GHCAEISSASFNWDCSLILTGSMDKTCKLWDATN-----------GKC 295

Query: 562 RGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVD 621
              L GH D +    +    + + + SADGT R+++      A +     K  G    + 
Sbjct: 296 VATLTGHDDEILDSCFDYTGKLIATASADGTARIFS------AATRKCIAKLEGHEGEIS 349

Query: 622 LVSSDP--SHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQIN 668
            +S +P  +H++   S     I++ +T Q +  LE + D     SC  N
Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEI--FSCAFN 396


>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
           sapiens]
          Length = 514

 Score = 76.3 bits (186), Expect = 1e-13
 Identities = 83/378 (21%), Positives = 146/378 (38%), Gaps = 61/378 (16%)

Query: 428 GLTVANEADSLTYDIANNKDALRKTW-------NPKFTLRSHFDGIRALAFHPIEPVLIT 480
           G   AN  ++  + IANN   + +         N    LR H   +   A++P+  +L +
Sbjct: 127 GENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLAS 186

Query: 481 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKG--------PVLCVVMSSNGEQCY 532
            S D T ++WNL     ++ STS   + +      +G         V  +  +S G    
Sbjct: 187 GSGDSTARIWNL-----SENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLA 241

Query: 533 SGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGT 592
           +G  DG  + W T + N           L   L  H   ++ L ++     +LS   D T
Sbjct: 242 TGSYDGFARIW-TKDGN-----------LASTLGQHKGPIFALKWNKKGNFILSAGVDKT 289

Query: 593 LRLWNT-TEVAPALSVFNDTKELGIP-ASVDLVSSDPSHMVASFSKGYTSIFNMETQQRI 650
             +W+  T  A     F+    L +   S +  +S  + M     K              
Sbjct: 290 TIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCK-------------- 335

Query: 651 LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVT 710
           L  +  + T    + ++N +   PT  +  +  +D  +K +       +H + AH + + 
Sbjct: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395

Query: 711 SLAVDPNG---------LYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFH 761
           ++   P G         L L S S D ++RLW+++   CI   T H    +E ++ VAF 
Sbjct: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKH----QEPVYSVAFS 451

Query: 762 PSKCYIASAGADALAKVF 779
           P   Y+AS   D    ++
Sbjct: 452 PDGRYLASGSFDKCVHIW 469


>gi|5174447 guanine nucleotide binding protein (G protein), beta
           polypeptide 2-like 1 [Homo sapiens]
          Length = 317

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 71/287 (24%), Positives = 127/287 (44%), Gaps = 28/287 (9%)

Query: 458 TLRSHFDGIRALAFHPIEP-VLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHK 516
           TL+ H   +  +A  P  P ++++AS D T+ MW L      +  T+  + P    R H 
Sbjct: 10  TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL-----TRDETNYGI-PQRALRGHS 63

Query: 517 GPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLA 576
             V  VV+SS+G+   SG  DG ++ W+ T                   +GHT  V  +A
Sbjct: 64  HFVSDVVISSDGQFALSGSWDGTLRLWDLTT-----------GTTTRRFVGHTKDVLSVA 112

Query: 577 YSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSK 636
           +S+ +++++S S D T++LWNT  V           E          SS+P  +   + K
Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172

Query: 637 GYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTG 696
               ++N+        L++N       +  +N V   P   +  +  +D     +D N G
Sbjct: 173 -LVKVWNLAN----CKLKTN---HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224

Query: 697 KLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQE 743
           K ++++    + + +L   PN  +L + +   SI++W+LE K  + E
Sbjct: 225 KHLYTLDGG-DIINALCFSPNRYWLCAATGP-SIKIWDLEGKIIVDE 269



 Score = 46.6 bits (109), Expect = 9e-05
 Identities = 54/222 (24%), Positives = 82/222 (36%), Gaps = 54/222 (24%)

Query: 561 LRGPLLGHTDAVWGLAYSAAH-QRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPAS 619
           LRG L GH   V  +A +      +LS S D T+ +W  T          D    GIP  
Sbjct: 7   LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR---------DETNYGIP-- 55

Query: 620 VDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPIS 679
                                       QR L   S+          ++ V+       +
Sbjct: 56  ----------------------------QRALRGHSHF---------VSDVVISSDGQFA 78

Query: 680 ITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKT 739
           ++   D  ++ +D  TG      V H + V S+A   +   ++SGS D +I+LWN     
Sbjct: 79  LSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG-- 136

Query: 740 CIQEFTAHRKKFEESIHDVAFHP--SKCYIASAGADALAKVF 779
            + ++T   +   E +  V F P  S   I S G D L KV+
Sbjct: 137 -VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177


>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
           [Homo sapiens]
          Length = 514

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 82/338 (24%), Positives = 137/338 (40%), Gaps = 49/338 (14%)

Query: 453 WNPKFTL----RSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEP 508
           W+P + L      H   +R +A  P     +T S D T+K+W+L   A  K   SL    
Sbjct: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL---ASGKLKLSL---- 242

Query: 509 IYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTT-NPNIDPYDSYDPSVLRGPLLG 567
                 H   V  V++S+     +S G D  ++ W+   N  I  Y             G
Sbjct: 243 ----TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYH------------G 286

Query: 568 HTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDP 627
           H  AV+GL        L++CS D T R+W+    A   ++   T  +   A+V   +++P
Sbjct: 287 HLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV---ATVRCQAAEP 343

Query: 628 SHMVASFSKGYTSIFNMETQQRILTLESNVD--TTANSSCQINRVISHPTLPISITAHED 685
             +  S           +T  R+  L +     T  N    +  V+ HP      +   D
Sbjct: 344 QIITGSH----------DTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD 393

Query: 686 RHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFT 745
            +IK +    G  I ++  H   + +L V+ +G+ L+SG+ + ++ LW+  +    Q   
Sbjct: 394 -NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRVH 451

Query: 746 AHRK----KFEESIHDVAFHPSKCYIASAGADALAKVF 779
           A  +      E  I   AF  S+  + +A AD   KV+
Sbjct: 452 AAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489



 Score = 37.4 bits (85), Expect = 0.054
 Identities = 25/110 (22%), Positives = 43/110 (39%), Gaps = 16/110 (14%)

Query: 440 YDIANNKDALRKTWNPKFT-----LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQK 494
           Y  +  +D   K W+ ++         H   +  L  HP   VL+T S D T ++W+++ 
Sbjct: 260 YLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRT 319

Query: 495 TAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWN 544
            A            ++T   H   V  V   +   Q  +G  D  I+ W+
Sbjct: 320 KA-----------SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358



 Score = 37.0 bits (84), Expect = 0.070
 Identities = 39/158 (24%), Positives = 66/158 (41%), Gaps = 29/158 (18%)

Query: 445 NKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAK 499
           ++D+  + W+ +      TL  H + +  +     EP +IT S D T+++W+L     A 
Sbjct: 307 SRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL----VAG 362

Query: 500 KSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPS 559
           K+         T   HK  V  VV+        SG  D           NI  +   D S
Sbjct: 363 KTR-------VTLTNHKKSVRAVVLHPRHYTFASGSPD-----------NIKQWKFPDGS 404

Query: 560 VLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 597
            ++  L GH   +  L  + +   L+S + +GT+ LW+
Sbjct: 405 FIQN-LSGHNAIINTLTVN-SDGVLVSGADNGTMHLWD 440


>gi|26665869 WD repeat domain 51B [Homo sapiens]
          Length = 478

 Score = 73.6 bits (179), Expect = 7e-13
 Identities = 80/329 (24%), Positives = 132/329 (40%), Gaps = 50/329 (15%)

Query: 447 DALRKTWNPKFTLRS-----HFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKS 501
           D     WN K   R+     H D + ++ F P   +L +AS D T+++W      P K+ 
Sbjct: 39  DTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW-----IPDKRG 93

Query: 502 TSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVL 561
              +      F+AH  PV  V  S++G+   +   D  I+ W+           Y    L
Sbjct: 94  KFSE------FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM----------YRQRFL 137

Query: 562 RGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVD 621
              L  HT  V    +S   + ++SCS D T+++W+TT       V N +  +G    VD
Sbjct: 138 YS-LYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ---CVNNFSDSVGFANFVD 193

Query: 622 LVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANS----SCQINRVISHPTLP 677
                       F+   T I +  + Q +   +  V+         S  +N +  HP+  
Sbjct: 194 ------------FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241

Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLW--NL 735
             ITA  D  +K  D   G+LI+++  H   V +++    G    SG  D  + LW  N 
Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF 301

Query: 736 ESKTC--IQEFTAHRKKFEESIHDVAFHP 762
           +   C  + +    R  F+   H +  +P
Sbjct: 302 DELHCKGLTKRNLKRLHFDSPPHLLDIYP 330



 Score = 73.2 bits (178), Expect = 9e-13
 Identities = 56/268 (20%), Positives = 112/268 (41%), Gaps = 28/268 (10%)

Query: 512 FRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDA 571
           F+ HK  +  + +S NG+Q  +   D  +  WN           + P       +GH D 
Sbjct: 14  FKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-----------FKPHARAYRYVGHKDV 62

Query: 572 VWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPA-SVDLVSSDPSHM 630
           V  + +S     L S S D T+RLW    +      F++ K    P  SVD  S+D   +
Sbjct: 63  VTSVQFSPHGNLLASASRDRTVRLW----IPDKRGKFSEFKAHTAPVRSVDF-SADGQFL 117

Query: 631 VASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKF 690
             +       +++M  Q+ + +L  +      +          P   + ++  ED+ IK 
Sbjct: 118 ATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFS-------PDGRLIVSCSEDKTIKI 170

Query: 691 YDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKK 750
           +D    + +++    +     +  +P+G  + S   D ++++W++     +Q +  H   
Sbjct: 171 WDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVH--- 227

Query: 751 FEESIHDVAFHPSKCYIASAGADALAKV 778
               ++ ++FHPS  Y+ +A +D   K+
Sbjct: 228 -SGGVNCISFHPSGNYLITASSDGTLKI 254



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 28/99 (28%), Positives = 44/99 (44%), Gaps = 4/99 (4%)

Query: 681 TAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTC 740
           TA  D  +  ++       +  V H + VTS+   P+G  L S S D ++RLW  + +  
Sbjct: 35  TASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGK 94

Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
             EF AH       +  V F     ++A+A  D   KV+
Sbjct: 95  FSEFKAH----TAPVRSVDFSADGQFLATASEDKSIKVW 129



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 4/76 (5%)

Query: 705 HLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSK 764
           H  A+TSL + PNG  L + S D  + LWN +       +  H+    + +  V F P  
Sbjct: 17  HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK----DVVTSVQFSPHG 72

Query: 765 CYIASAGADALAKVFV 780
             +ASA  D   ++++
Sbjct: 73  NLLASASRDRTVRLWI 88


>gi|21071067 TBP-associated factor 5 [Homo sapiens]
          Length = 800

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 52/219 (23%), Positives = 90/219 (41%), Gaps = 30/219 (13%)

Query: 440 YDIANNKDALRKTW-----NPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQK 494
           Y ++   D + + W      P      H   +    FHP    + T S D T+++W++  
Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV-- 656

Query: 495 TAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYD 554
                    L+   +  F  HKGP+  +  S NG    +G TDG +  W+  +       
Sbjct: 657 ---------LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH------- 700

Query: 555 SYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKEL 614
                ++ G L GHTD V  L +S   + L S S D T+RLW+  +    L   + T   
Sbjct: 701 ----GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTAT 756

Query: 615 GIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTL 653
           G    ++L  +    ++ ++    T + ++   +R L L
Sbjct: 757 G---HINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVL 792



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 42/183 (22%), Positives = 70/183 (38%), Gaps = 11/183 (6%)

Query: 565 LLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVS 624
           L GH+  V+G ++S     LLS S DGT+RLW+       +      K    P      S
Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY----KGHNYPVWDTQFS 594

Query: 625 SDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHE 684
               + V+        ++  +  Q +     ++         +N    HP      T   
Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL-------ADVNCTRFHPNSNYVATGSA 647

Query: 685 DRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEF 744
           DR ++ +D   G  +     H   + SL   PNG +L +G+ D  + LW++     + E 
Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707

Query: 745 TAH 747
             H
Sbjct: 708 KGH 710



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 81/364 (22%), Positives = 126/364 (34%), Gaps = 49/364 (13%)

Query: 377 PSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGAD--EALESELGLGELAGLTVANE 434
           P+ P  +R+P  E+  +D+++ +     + K   +G D   ++     L    GLT  + 
Sbjct: 419 PNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDV 478

Query: 435 ADSLTYDIANNKDALRKTWN--PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNL 492
            D  +       D+  + W+  PK  LRS             +  LI    D  L+    
Sbjct: 479 TDDSSLIAGGFADSTVRVWSVTPK-KLRS--------VKQASDLSLIDKESDDVLERIMD 529

Query: 493 QKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDP 552
           +KTA   K              H GPV     S +     S   DG ++ W         
Sbjct: 530 EKTASELK----------ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW--------- 570

Query: 553 YDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTK 612
             S           GH   VW   +S      +S   D   RLW T    P L +F    
Sbjct: 571 --SLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQP-LRIF---- 623

Query: 613 ELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRIL-TLESN-VDTTANSSCQINRV 670
             G  A V+     P+         Y +  + +   R+   L  N V         I+ +
Sbjct: 624 -AGHLADVNCTRFHPN-------SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL 675

Query: 671 ISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSI 730
              P      T   D  +  +D   G ++  +  H + V SL    +G  L SGS D ++
Sbjct: 676 TFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTV 735

Query: 731 RLWN 734
           RLW+
Sbjct: 736 RLWD 739



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 25/91 (27%), Positives = 43/91 (47%), Gaps = 4/91 (4%)

Query: 689 KFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHR 748
           +  D  T   +  +  H   V   +  P+  YL+S S D ++RLW+L++ TC+  +  H 
Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH- 584

Query: 749 KKFEESIHDVAFHPSKCYIASAGADALAKVF 779
                 + D  F P   Y  S G D +A+++
Sbjct: 585 ---NYPVWDTQFSPYGYYFVSGGHDRVARLW 612



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 24/94 (25%), Positives = 46/94 (48%), Gaps = 4/94 (4%)

Query: 680 ITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKT 739
           ++   DR  + +  +  + +     HL  V      PN  Y+ +GS D ++RLW++ +  
Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660

Query: 740 CIQEFTAHRKKFEESIHDVAFHPSKCYIASAGAD 773
           C++ FT H+      IH + F P+  ++A+   D
Sbjct: 661 CVRIFTGHK----GPIHSLTFSPNGRFLATGATD 690



 Score = 43.5 bits (101), Expect = 8e-04
 Identities = 24/100 (24%), Positives = 43/100 (43%), Gaps = 4/100 (4%)

Query: 680 ITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKT 739
           +++ ED  ++ +   T   +     H   V      P G Y +SG HD   RLW  +   
Sbjct: 559 LSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ 618

Query: 740 CIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
            ++ F  H       ++   FHP+  Y+A+  AD   +++
Sbjct: 619 PLRIFAGHL----ADVNCTRFHPNSNYVATGSADRTVRLW 654


>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 73/339 (21%), Positives = 129/339 (38%), Gaps = 52/339 (15%)

Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP 518
           LR H   +   A++P+  +L + S D T ++WNL + +    ST L +        H  P
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREGGHDVP 235

Query: 519 ----VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWG 574
               V  +  ++NG    +G  DG  + W             +   L   L  H   ++ 
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 283

Query: 575 LAYSAAHQRLLSCSADGTLRLWNT-TEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633
           L ++     +LS   D T  +W+  T  A     F+    L +                 
Sbjct: 284 LKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--------------- 328

Query: 634 FSKGYTSIFNMETQQRI----LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIK 689
             +  T+  +  T   I    L  +  V T    + ++N +   P+  +  +  +D  +K
Sbjct: 329 --QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK 386

Query: 690 FYDNNTGKLIHSMVAHLEAVTSLAVDPNG---------LYLMSGSHDCSIRLWNLESKTC 740
            +       IH + AH + + ++   P G         + L S S D ++RLW++E   C
Sbjct: 387 IWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 446

Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
               T H    +E ++ VAF P   Y+AS   D    ++
Sbjct: 447 THTLTKH----QEPVYSVAFSPDGKYLASGSFDKCVHIW 481



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 57/274 (20%), Positives = 107/274 (39%), Gaps = 56/274 (20%)

Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE----VAPALSVFNDTKE 613
           PS     L GH   V+  A++     L S S D T R+WN  E     +  L + +  +E
Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229

Query: 614 LG--IPASVDLVSSD----------------------PSHMVASFSKGYTSIFNMETQQR 649
            G  +P++ D+ S D                        ++ ++  +    IF ++  ++
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 289

Query: 650 -ILTLESNVDTT-------ANSSCQINRVISHPTLPIS-------ITAHEDRHIKFYDNN 694
               L + VD T          + Q     S P L +         +   D  I      
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 349

Query: 695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEES 754
             + + +   H   V ++  DP+G+ L S S D ++++W+++ + CI +  AH K+    
Sbjct: 350 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKE---- 405

Query: 755 IHDVAFHP---------SKCYIASAGADALAKVF 779
           I+ + + P         S   +ASA  D+  +++
Sbjct: 406 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439


>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
          Length = 526

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 73/339 (21%), Positives = 129/339 (38%), Gaps = 52/339 (15%)

Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP 518
           LR H   +   A++P+  +L + S D T ++WNL + +    ST L +        H  P
Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREGGHDVP 235

Query: 519 ----VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWG 574
               V  +  ++NG    +G  DG  + W             +   L   L  H   ++ 
Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 283

Query: 575 LAYSAAHQRLLSCSADGTLRLWNT-TEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633
           L ++     +LS   D T  +W+  T  A     F+    L +                 
Sbjct: 284 LKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--------------- 328

Query: 634 FSKGYTSIFNMETQQRI----LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIK 689
             +  T+  +  T   I    L  +  V T    + ++N +   P+  +  +  +D  +K
Sbjct: 329 --QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK 386

Query: 690 FYDNNTGKLIHSMVAHLEAVTSLAVDPNG---------LYLMSGSHDCSIRLWNLESKTC 740
            +       IH + AH + + ++   P G         + L S S D ++RLW++E   C
Sbjct: 387 IWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 446

Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
               T H    +E ++ VAF P   Y+AS   D    ++
Sbjct: 447 THTLTKH----QEPVYSVAFSPDGKYLASGSFDKCVHIW 481



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 57/274 (20%), Positives = 107/274 (39%), Gaps = 56/274 (20%)

Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE----VAPALSVFNDTKE 613
           PS     L GH   V+  A++     L S S D T R+WN  E     +  L + +  +E
Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229

Query: 614 LG--IPASVDLVSSD----------------------PSHMVASFSKGYTSIFNMETQQR 649
            G  +P++ D+ S D                        ++ ++  +    IF ++  ++
Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 289

Query: 650 -ILTLESNVDTT-------ANSSCQINRVISHPTLPIS-------ITAHEDRHIKFYDNN 694
               L + VD T          + Q     S P L +         +   D  I      
Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 349

Query: 695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEES 754
             + + +   H   V ++  DP+G+ L S S D ++++W+++ + CI +  AH K+    
Sbjct: 350 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKE---- 405

Query: 755 IHDVAFHP---------SKCYIASAGADALAKVF 779
           I+ + + P         S   +ASA  D+  +++
Sbjct: 406 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439


>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 73/339 (21%), Positives = 129/339 (38%), Gaps = 52/339 (15%)

Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP 518
           LR H   +   A++P+  +L + S D T ++WNL + +    ST L +        H  P
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREGGHDVP 286

Query: 519 ----VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWG 574
               V  +  ++NG    +G  DG  + W             +   L   L  H   ++ 
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 334

Query: 575 LAYSAAHQRLLSCSADGTLRLWNT-TEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633
           L ++     +LS   D T  +W+  T  A     F+    L +                 
Sbjct: 335 LKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--------------- 379

Query: 634 FSKGYTSIFNMETQQRI----LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIK 689
             +  T+  +  T   I    L  +  V T    + ++N +   P+  +  +  +D  +K
Sbjct: 380 --QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK 437

Query: 690 FYDNNTGKLIHSMVAHLEAVTSLAVDPNG---------LYLMSGSHDCSIRLWNLESKTC 740
            +       IH + AH + + ++   P G         + L S S D ++RLW++E   C
Sbjct: 438 IWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 497

Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
               T H    +E ++ VAF P   Y+AS   D    ++
Sbjct: 498 THTLTKH----QEPVYSVAFSPDGKYLASGSFDKCVHIW 532



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 57/274 (20%), Positives = 107/274 (39%), Gaps = 56/274 (20%)

Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE----VAPALSVFNDTKE 613
           PS     L GH   V+  A++     L S S D T R+WN  E     +  L + +  +E
Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280

Query: 614 LG--IPASVDLVSSD----------------------PSHMVASFSKGYTSIFNMETQQR 649
            G  +P++ D+ S D                        ++ ++  +    IF ++  ++
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 340

Query: 650 -ILTLESNVDTT-------ANSSCQINRVISHPTLPIS-------ITAHEDRHIKFYDNN 694
               L + VD T          + Q     S P L +         +   D  I      
Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 400

Query: 695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEES 754
             + + +   H   V ++  DP+G+ L S S D ++++W+++ + CI +  AH K+    
Sbjct: 401 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKE---- 456

Query: 755 IHDVAFHP---------SKCYIASAGADALAKVF 779
           I+ + + P         S   +ASA  D+  +++
Sbjct: 457 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490


>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
          Length = 577

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 73/339 (21%), Positives = 129/339 (38%), Gaps = 52/339 (15%)

Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP 518
           LR H   +   A++P+  +L + S D T ++WNL + +    ST L +        H  P
Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREGGHDVP 286

Query: 519 ----VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWG 574
               V  +  ++NG    +G  DG  + W             +   L   L  H   ++ 
Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 334

Query: 575 LAYSAAHQRLLSCSADGTLRLWNT-TEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633
           L ++     +LS   D T  +W+  T  A     F+    L +                 
Sbjct: 335 LKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--------------- 379

Query: 634 FSKGYTSIFNMETQQRI----LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIK 689
             +  T+  +  T   I    L  +  V T    + ++N +   P+  +  +  +D  +K
Sbjct: 380 --QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK 437

Query: 690 FYDNNTGKLIHSMVAHLEAVTSLAVDPNG---------LYLMSGSHDCSIRLWNLESKTC 740
            +       IH + AH + + ++   P G         + L S S D ++RLW++E   C
Sbjct: 438 IWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 497

Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
               T H    +E ++ VAF P   Y+AS   D    ++
Sbjct: 498 THTLTKH----QEPVYSVAFSPDGKYLASGSFDKCVHIW 532



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 57/274 (20%), Positives = 107/274 (39%), Gaps = 56/274 (20%)

Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE----VAPALSVFNDTKE 613
           PS     L GH   V+  A++     L S S D T R+WN  E     +  L + +  +E
Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280

Query: 614 LG--IPASVDLVSSD----------------------PSHMVASFSKGYTSIFNMETQQR 649
            G  +P++ D+ S D                        ++ ++  +    IF ++  ++
Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 340

Query: 650 -ILTLESNVDTT-------ANSSCQINRVISHPTLPIS-------ITAHEDRHIKFYDNN 694
               L + VD T          + Q     S P L +         +   D  I      
Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 400

Query: 695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEES 754
             + + +   H   V ++  DP+G+ L S S D ++++W+++ + CI +  AH K+    
Sbjct: 401 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKE---- 456

Query: 755 IHDVAFHP---------SKCYIASAGADALAKVF 779
           I+ + + P         S   +ASA  D+  +++
Sbjct: 457 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490


>gi|16554629 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 73/323 (22%), Positives = 136/323 (42%), Gaps = 43/323 (13%)

Query: 456 KFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAH 515
           KFTL  H   + ++ F P    L ++S D  +K+W            + D +   T   H
Sbjct: 38  KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFEKTISGH 86

Query: 516 KGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGL 575
           K  +  V  SS+     S   D  ++ W+ ++                 L GH++ V+  
Sbjct: 87  KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC-----------LKTLKGHSNYVFCC 135

Query: 576 AYSAAHQRLLSCSADGTLRLWN--TTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633
            ++     ++S S D ++R+W+  T +    L   +D      P S    + D S +V+S
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD------PVSAVHFNRDGSLIVSS 189

Query: 634 FSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDN 693
              G   I++  + Q + TL   +D   + +  ++ V   P     + A  D  +K +D 
Sbjct: 190 SYDGLCRIWDTASGQCLKTL---ID---DDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 694 NTGKLIHSMVAHLEAVTSLAVD---PNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKK 750
           + GK + +   H      +  +     G +++SGS D  + +WNL++K  +Q+   H   
Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH--- 300

Query: 751 FEESIHDVAFHPSKCYIASAGAD 773
             + +   A HP++  IASA  +
Sbjct: 301 -TDVVISTACHPTENIIASAALE 322



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 63/263 (23%), Positives = 118/263 (44%), Gaps = 31/263 (11%)

Query: 495 TAPAKKSTSLDVEPIY----TFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNI 550
           ++ A +S    V+P Y    T   H   V  V  S NGE   S   D LI+ W       
Sbjct: 20  SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----- 74

Query: 551 DPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFND 610
             YD      + G  LG +D  W    S+    L+S S D TL++W+ +     L     
Sbjct: 75  --YDGKFEKTISGHKLGISDVAW----SSDSNLLVSASDDKTLKIWDVSS-GKCLKTLK- 126

Query: 611 TKELGIPASVDLVSSDP-SHMVASFSKGYT-SIFNMETQQRILTLESNVDTTANSSCQIN 668
               G    V   + +P S+++ S S   +  I++++T + + TL ++ D    S+   N
Sbjct: 127 ----GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV--SAVHFN 180

Query: 669 RVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEA-VTSLAVDPNGLYLMSGSHD 727
           R  S     + +++  D   + +D  +G+ + +++      V+ +   PNG Y+++ + D
Sbjct: 181 RDGS-----LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD 235

Query: 728 CSIRLWNLESKTCIQEFTAHRKK 750
            +++LW+     C++ +T H+ +
Sbjct: 236 NTLKLWDYSKGKCLKTYTGHKNE 258



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 56/222 (25%), Positives = 105/222 (47%), Gaps = 20/222 (9%)

Query: 561 LRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASV 620
           L+  L GHT AV  + +S   + L S SAD  +++W   +     ++     +LGI    
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH--KLGIS--- 91

Query: 621 DLVSSDPSHMVASFSKGYT-SIFNMETQQRILTLE--SNVDTTANSSCQINRVISHPTLP 677
           D+  S  S+++ S S   T  I+++ + + + TL+  SN     N + Q N ++S     
Sbjct: 92  DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS----- 146

Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737
                  D  ++ +D  TGK + ++ AH + V+++  + +G  ++S S+D   R+W+  S
Sbjct: 147 ----GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202

Query: 738 KTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
             C++            +  V F P+  YI +A  D   K++
Sbjct: 203 GQCLKTLI---DDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241


>gi|16554627 WD repeat domain 5 [Homo sapiens]
          Length = 334

 Score = 71.6 bits (174), Expect = 3e-12
 Identities = 73/323 (22%), Positives = 136/323 (42%), Gaps = 43/323 (13%)

Query: 456 KFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAH 515
           KFTL  H   + ++ F P    L ++S D  +K+W            + D +   T   H
Sbjct: 38  KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFEKTISGH 86

Query: 516 KGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGL 575
           K  +  V  SS+     S   D  ++ W+ ++                 L GH++ V+  
Sbjct: 87  KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC-----------LKTLKGHSNYVFCC 135

Query: 576 AYSAAHQRLLSCSADGTLRLWN--TTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633
            ++     ++S S D ++R+W+  T +    L   +D      P S    + D S +V+S
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD------PVSAVHFNRDGSLIVSS 189

Query: 634 FSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDN 693
              G   I++  + Q + TL   +D   + +  ++ V   P     + A  D  +K +D 
Sbjct: 190 SYDGLCRIWDTASGQCLKTL---ID---DDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243

Query: 694 NTGKLIHSMVAHLEAVTSLAVD---PNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKK 750
           + GK + +   H      +  +     G +++SGS D  + +WNL++K  +Q+   H   
Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH--- 300

Query: 751 FEESIHDVAFHPSKCYIASAGAD 773
             + +   A HP++  IASA  +
Sbjct: 301 -TDVVISTACHPTENIIASAALE 322



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 63/263 (23%), Positives = 118/263 (44%), Gaps = 31/263 (11%)

Query: 495 TAPAKKSTSLDVEPIY----TFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNI 550
           ++ A +S    V+P Y    T   H   V  V  S NGE   S   D LI+ W       
Sbjct: 20  SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----- 74

Query: 551 DPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFND 610
             YD      + G  LG +D  W    S+    L+S S D TL++W+ +     L     
Sbjct: 75  --YDGKFEKTISGHKLGISDVAW----SSDSNLLVSASDDKTLKIWDVSS-GKCLKTLK- 126

Query: 611 TKELGIPASVDLVSSDP-SHMVASFSKGYT-SIFNMETQQRILTLESNVDTTANSSCQIN 668
               G    V   + +P S+++ S S   +  I++++T + + TL ++ D    S+   N
Sbjct: 127 ----GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV--SAVHFN 180

Query: 669 RVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEA-VTSLAVDPNGLYLMSGSHD 727
           R  S     + +++  D   + +D  +G+ + +++      V+ +   PNG Y+++ + D
Sbjct: 181 RDGS-----LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD 235

Query: 728 CSIRLWNLESKTCIQEFTAHRKK 750
            +++LW+     C++ +T H+ +
Sbjct: 236 NTLKLWDYSKGKCLKTYTGHKNE 258



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 56/222 (25%), Positives = 105/222 (47%), Gaps = 20/222 (9%)

Query: 561 LRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASV 620
           L+  L GHT AV  + +S   + L S SAD  +++W   +     ++     +LGI    
Sbjct: 37  LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH--KLGIS--- 91

Query: 621 DLVSSDPSHMVASFSKGYT-SIFNMETQQRILTLE--SNVDTTANSSCQINRVISHPTLP 677
           D+  S  S+++ S S   T  I+++ + + + TL+  SN     N + Q N ++S     
Sbjct: 92  DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS----- 146

Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737
                  D  ++ +D  TGK + ++ AH + V+++  + +G  ++S S+D   R+W+  S
Sbjct: 147 ----GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202

Query: 738 KTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
             C++            +  V F P+  YI +A  D   K++
Sbjct: 203 GQCLKTLI---DDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241


>gi|21536371 telomerase-associated protein 1 [Homo sapiens]
          Length = 2627

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 67/277 (24%), Positives = 120/277 (43%), Gaps = 22/277 (7%)

Query: 475  EPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYT-FRAHKGPVLCVVMSSNGEQCYS 533
            + +L +ASED T+++W  Q      K+      P  T  R H+GPV C   S++G    +
Sbjct: 2022 QELLASASEDFTVQLWPRQLLTRPHKAEDF---PCGTELRGHEGPVSCCSFSTDGGSLAT 2078

Query: 534  GGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTL 593
            GG D  +  W+   P         P ++      H D V G A++     L+SCS+DG++
Sbjct: 2079 GGRDRSLLCWDVRTPK-------TPVLIHSFPACHRDWVTGCAWT-KDNLLISCSSDGSV 2130

Query: 594  RLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTL 653
             LW+  E    L  F     LG  ++V  V++   H+V+    G   +++ +  +     
Sbjct: 2131 GLWD-PESGQRLGQF-----LGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIP 2184

Query: 654  ESNVDTTANSSCQINRVISHP-TLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSL 712
              +   +  ++    R    P +  + +T   D   + +        H+++ H   V + 
Sbjct: 2185 AHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAA 2244

Query: 713  AVDPNGLYLMSGSHDCSIRLWNLESK---TCIQEFTA 746
            AV      +++ S D S+RLW +  +   TCI   +A
Sbjct: 2245 AVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA 2281



 Score = 36.6 bits (83), Expect = 0.092
 Identities = 35/149 (23%), Positives = 61/149 (40%), Gaps = 22/149 (14%)

Query: 353  KLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMG 412
            +L   L +   V  + +++  V S SR  + ++ +H+      VE  + P  SG   I  
Sbjct: 2140 RLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQ-----GVELTSIPAHSGP--ISH 2192

Query: 413  ADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKF-----TLRSHFDGIR 467
               A+E             A +  S    +    D   + W+P       TL  H   +R
Sbjct: 2193 CAAAMEPR----------AAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVR 2242

Query: 468  ALAFHPIEPVLITASEDHTLKMWNLQKTA 496
            A A      +++TASED ++++W + K A
Sbjct: 2243 AAAVSETSGLMLTASEDGSVRLWQVPKEA 2271



 Score = 35.0 bits (79), Expect = 0.27
 Identities = 71/323 (21%), Positives = 108/323 (33%), Gaps = 91/323 (28%)

Query: 461  SHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYT--------- 511
            +H   + A  F      L+TA ED  +++W+     P     SL + P  +         
Sbjct: 1882 AHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941

Query: 512  ----FRAHKGPVLCVVMSSNGEQ------------------CYSGGTDGLIQGWNTTNPN 549
                +RA    +  +   S G Q                    SG  DG +QGW     +
Sbjct: 1942 VAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECS 2001

Query: 550  IDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFN 609
            +     +  S  + P+LG          + + + L S S D T++LW      P   +  
Sbjct: 2002 LQ--SLWLLSRFQKPVLG---------LATSQELLASASEDFTVQLW------PRQLLTR 2044

Query: 610  DTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINR 669
              K    P   +L   +      SFS    S+                            
Sbjct: 2045 PHKAEDFPCGTELRGHEGPVSCCSFSTDGGSL---------------------------- 2076

Query: 670  VISHPTLPISITAHEDRHIKFYDNNTGK---LIHSMVA-HLEAVTSLAVDPNGLYLMSGS 725
                       T   DR +  +D  T K   LIHS  A H + VT  A   + L L+S S
Sbjct: 2077 ----------ATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCS 2125

Query: 726  HDCSIRLWNLESKTCIQEFTAHR 748
             D S+ LW+ ES   + +F  H+
Sbjct: 2126 SDGSVGLWDPESGQRLGQFLGHQ 2148


>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
          Length = 589

 Score = 70.5 bits (171), Expect = 6e-12
 Identities = 75/308 (24%), Positives = 115/308 (37%), Gaps = 49/308 (15%)

Query: 473 PIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCY 532
           P   +L    ++  +K+W+L+      +   +DV  I+        + C ++    ++  
Sbjct: 278 PDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIH--------LACDILEEEDDEDD 329

Query: 533 SGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGT 592
           + GT+  I                        L GH   V+   + A    LLSCS D +
Sbjct: 330 NAGTEMKI------------------------LRGHCGPVYSTRFLADSSGLLSCSEDMS 365

Query: 593 LRLWNTTEVAPALSVFNDTKELGIPASV-DLVSSDPSHMVASFSKGYTSIFNMETQQRIL 651
           +R W+        S  N     G    V DL  S  S   AS S   T+   + +  R  
Sbjct: 366 IRYWDLG------SFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTA--RLWSFDRTY 417

Query: 652 TLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTS 711
            L       A+  C    V  HP      T   D+ ++ +    G  +     H   V S
Sbjct: 418 PLRIYAGHLADVDC----VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLS 473

Query: 712 LAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAG 771
           LA  PNG YL S   D  ++LW+L S T  +E   H     ++I  + F P    IASA 
Sbjct: 474 LAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGH----TDNITSLTFSPDSGLIASAS 529

Query: 772 ADALAKVF 779
            D   +V+
Sbjct: 530 MDNSVRVW 537



 Score = 64.3 bits (155), Expect = 4e-10
 Identities = 46/173 (26%), Positives = 71/173 (41%), Gaps = 30/173 (17%)

Query: 440 YDIANNKDALRKTWN-----PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQK 494
           Y  + + D   + W+     P      H   +  + FHP    L T S D T+++W+ Q+
Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457

Query: 495 TAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYD 554
                         +  F  H+GPVL +  S NG+   S G D  ++ W+  +       
Sbjct: 458 G-----------NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS------- 499

Query: 555 SYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLW---NTTEVAPA 604
                 L   L GHTD +  L +S     + S S D ++R+W   NT   APA
Sbjct: 500 ----GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPA 548



 Score = 37.7 bits (86), Expect = 0.041
 Identities = 20/56 (35%), Positives = 36/56 (64%), Gaps = 4/56 (7%)

Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKT---APAKKSTSLDVEPIYT 511
           LR H D I +L F P   ++ +AS D+++++W+++ T   APA  S+S ++  +YT
Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSS-ELVGVYT 560


>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
          Length = 485

 Score = 70.1 bits (170), Expect = 7e-12
 Identities = 87/393 (22%), Positives = 146/393 (37%), Gaps = 89/393 (22%)

Query: 458 TLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKG 517
           +L  H + + ++AF P    L + S D T++ W+L    P            +T + H+ 
Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPH-----------FTCKGHRH 157

Query: 518 PVLCVVMSSNGEQCYSGGTDGLIQGWNTT--------------------------NPNID 551
            VL +  S +G +  SG  +G I  W+ +                          NP   
Sbjct: 158 WVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECR 217

Query: 552 --PYDSYDPSV---------LRGPLLGHTDAV----WG---LAYSA----------AHQR 583
                S D SV             L GHT +V    WG   L YSA          AH  
Sbjct: 218 YVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDG 277

Query: 584 LLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFN 643
           +L  +  G     NT  ++   ++     E   PA   +   D    +    +   S +N
Sbjct: 278 VLCRTLQGHGHWVNTMALSTDYALRTGAFE---PAEASVNPQDLQGSLQELKERALSRYN 334

Query: 644 METQQRILTLESNVDT-----------------TANSSCQINRVISHPTLPISITAHEDR 686
           +   Q    L S  D                         IN+V+  P   I  +A  D+
Sbjct: 335 LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDK 394

Query: 687 HIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTA 746
            IK +D  TGK + S+  H+ AV  +A   +   L+SGS D ++++W+++++    +   
Sbjct: 395 SIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG 454

Query: 747 HRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779
           H     + ++ V + P    +AS G D   +++
Sbjct: 455 H----ADEVYAVDWSPDGQRVASGGKDKCLRIW 483


>gi|13376840 WD repeat domain 61 [Homo sapiens]
          Length = 305

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 69/296 (23%), Positives = 130/296 (43%), Gaps = 35/296 (11%)

Query: 478 LITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTD 537
           ++T S D  +K+W         +   LD++  ++   H+  V+ V +S       S   D
Sbjct: 35  VVTGSLDDLVKVWKW-------RDERLDLQ--WSLEGHQLGVVSVDISHTLPIAASSSLD 85

Query: 538 GLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 597
             I+ W+  N           S+  GP+    DA W LA+S   Q L + +  G + ++ 
Sbjct: 86  AHIRLWDLEN------GKQIKSIDAGPV----DA-WTLAFSPDSQYLATGTHVGKVNIFG 134

Query: 598 TTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNV 657
                   S+  DT+   I +     S D  ++ +    G  +IF++ T + + TLE + 
Sbjct: 135 VESGKKEYSL--DTRGKFILSIA--YSPDGKYLASGAIDGIINIFDIATGKLLHTLEGH- 189

Query: 658 DTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPN 717
                 +  I  +   P   + +TA +D +IK YD     L  ++  H   V ++A  P+
Sbjct: 190 ------AMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPD 243

Query: 718 GLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGAD 773
             + +S S D S+++W++ ++TC+  F  H    ++ +  V ++ +   I S G D
Sbjct: 244 DTHFVSSSSDKSVKVWDVGTRTCVHTFFDH----QDQVWGVKYNGNGSKIVSVGDD 295



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 33/141 (23%), Positives = 58/141 (41%), Gaps = 24/141 (17%)

Query: 458 TLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKG 517
           TL  H   IR+L F P   +L+TAS+D  +K++++Q    A            T   H  
Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAG-----------TLSGHAS 233

Query: 518 PVLCVVMSSNGEQCYSGGTDGLIQGWNT-TNPNIDPYDSYDPSVLRGPLLGHTDAVWGLA 576
            VL V    +     S  +D  ++ W+  T   +  +              H D VWG+ 
Sbjct: 234 WVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF------------FDHQDQVWGVK 281

Query: 577 YSAAHQRLLSCSADGTLRLWN 597
           Y+    +++S   D  + +++
Sbjct: 282 YNGNGSKIVSVGDDQEIHIYD 302


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.130    0.375 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,314,394
Number of Sequences: 37866
Number of extensions: 1411282
Number of successful extensions: 8209
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 220
Number of HSP's successfully gapped in prelim test: 241
Number of HSP's that attempted gapping in prelim test: 5624
Number of HSP's gapped (non-prelim): 1877
length of query: 780
length of database: 18,247,518
effective HSP length: 110
effective length of query: 670
effective length of database: 14,082,258
effective search space: 9435112860
effective search space used: 9435112860
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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