BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|51242945 striatin, calmodulin binding protein [Homo sapiens] (780 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|51242945 striatin, calmodulin binding protein [Homo sapiens] 1564 0.0 gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] 998 0.0 gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] 783 0.0 gi|89886480 zinedin isoform 2 [Homo sapiens] 707 0.0 gi|89886477 zinedin isoform 1 [Homo sapiens] 707 0.0 gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens] 119 8e-27 gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens] 119 8e-27 gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens] 117 4e-26 gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 84 5e-16 gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 83 1e-15 gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 83 1e-15 gi|148536855 coatomer protein complex, subunit alpha isoform 1 [... 80 7e-15 gi|148536853 coatomer protein complex, subunit alpha isoform 2 [... 80 7e-15 gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 79 2e-14 gi|32189425 WD repeat domain 69 [Homo sapiens] 79 2e-14 gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 76 1e-13 gi|5174447 guanine nucleotide binding protein (G protein), beta ... 76 1e-13 gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 74 7e-13 gi|26665869 WD repeat domain 51B [Homo sapiens] 74 7e-13 gi|21071067 TBP-associated factor 5 [Homo sapiens] 72 2e-12 gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 72 2e-12 gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 72 2e-12 gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 72 2e-12 gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 72 2e-12 gi|16554629 WD repeat domain 5 [Homo sapiens] 72 3e-12 gi|16554627 WD repeat domain 5 [Homo sapiens] 72 3e-12 gi|21536371 telomerase-associated protein 1 [Homo sapiens] 70 6e-12 gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 70 6e-12 gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 70 7e-12 gi|13376840 WD repeat domain 61 [Homo sapiens] 69 1e-11 >gi|51242945 striatin, calmodulin binding protein [Homo sapiens] Length = 780 Score = 1564 bits (4049), Expect = 0.0 Identities = 780/780 (100%), Positives = 780/780 (100%) Query: 1 MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEW 60 MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEW Sbjct: 1 MDEQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEW 60 Query: 61 ARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLK 120 ARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLK Sbjct: 61 ARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLK 120 Query: 121 YGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS 180 YGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS Sbjct: 121 YGTELNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKS 180 Query: 181 KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA 240 KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA Sbjct: 181 KRVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA 240 Query: 241 AADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNE 300 AADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNE Sbjct: 241 AADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNE 300 Query: 301 SRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN 360 SRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN Sbjct: 301 SRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN 360 Query: 361 LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE 420 LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE Sbjct: 361 LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE 420 Query: 421 LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT 480 LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT Sbjct: 421 LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT 480 Query: 481 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI 540 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI Sbjct: 481 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI 540 Query: 541 QGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE 600 QGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE Sbjct: 541 QGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE 600 Query: 601 VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT 660 VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT Sbjct: 601 VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT 660 Query: 661 ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY 720 ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY Sbjct: 661 ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY 720 Query: 721 LMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV 780 LMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV Sbjct: 721 LMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV 780 >gi|142976686 nuclear autoantigen isoform 1 [Homo sapiens] Length = 797 Score = 998 bits (2580), Expect = 0.0 Identities = 505/787 (64%), Positives = 616/787 (78%), Gaps = 18/787 (2%) Query: 3 EQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWAR 62 +Q GPG + G G A G GP A + AG A + QY++PGILH++QHEWAR Sbjct: 20 QQQGPGGNLGLSPGGNGAAGGGGPPA-SEGAGPAAGPELSRPQQYTIPGILHYIQHEWAR 78 Query: 63 FEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 122 FE+ERA WEVERAELQA+IAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG Sbjct: 79 FEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 138 Query: 123 TELNQGDMKPPSYDSDEGNETEVQPQ-QNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSK 181 TELNQGD+K P+++S+E +TE QNSQL WKQGRQLLRQYLQEVGYTDTILDV+S+ Sbjct: 139 TELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYTDTILDVRSQ 198 Query: 182 RVRALLGFS-SDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESA 240 RVR+LLG S S+ + KN + ++NG E+ ++ I +S S VL+ F FLE+A Sbjct: 199 RVRSLLGLSNSEPNGSVETKNLEQILNGGESPKQKGQEIKRS----SGDVLETFNFLENA 254 Query: 241 AADFSDEDEDDDV-----DGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSE 295 D SDEDE++D+ +G++K ++ I + D +D DT+EALKEFDFLVT+E Sbjct: 255 --DDSDEDEENDMIEGIPEGKDKHRMNKHKIGNEGLAADLTDDPDTEEALKEFDFLVTAE 312 Query: 296 EGDN--ESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSK 353 +G+ E+RS+GDGT+W+K+D E W+VDQG+I+KLKEQYKKERKGKKGVKR NR+K Sbjct: 313 DGEGAGEARSSGDGTEWDKDDLSPTAEVWDVDQGLISKLKEQYKKERKGKKGVKRANRTK 372 Query: 354 LQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGA 413 L DM+A+L D DELP + + + SR +S+R+ +HE RA+E E +TFP GKSFIMG+ Sbjct: 373 LYDMIADLGD-DELPHIPSGIINQSRSASTRMTDHEGARAEEAEPITFPSGGGKSFIMGS 431 Query: 414 DEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHP 473 D+ L S LGLG+LA LTV N+AD +YD+ NKDA RKTWNPK+TLRSHFDG+RALAFHP Sbjct: 432 DDVLLSVLGLGDLADLTVTNDAD-YSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHP 490 Query: 474 IEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYS 533 +EPVL+TASEDHTLK+WNLQKT PAKKS SLDVEPIYTFRAH GPVL + +SSNGEQC+S Sbjct: 491 VEPVLVTASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFS 550 Query: 534 GGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTL 593 GG D IQ WN +P++DPYD+Y+P+VL G L+GHTDAVWGLAYS +LLSCSADGT+ Sbjct: 551 GGIDATIQWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTV 610 Query: 594 RLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTL 653 RLWN E P + +N K+ GIP SVD + DP+HMV SF+ G I+++ET Q ++ L Sbjct: 611 RLWNPQEKLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVIL 670 Query: 654 ESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLA 713 S VD+ S+ INRV+SHPTLP++ITAHEDRHIKF+DN TGK+IHSMVAHL+AVTSLA Sbjct: 671 SSQVDSGLQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLA 730 Query: 714 VDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGAD 773 VDPNG+YLMSGSHDCSIRLWNL+SKTC+QE TAHRKK +ESI+DVAFH SK YIASAGAD Sbjct: 731 VDPNGIYLMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGAD 790 Query: 774 ALAKVFV 780 ALAKVFV Sbjct: 791 ALAKVFV 797 >gi|142976675 nuclear autoantigen isoform 2 [Homo sapiens] Length = 713 Score = 783 bits (2021), Expect = 0.0 Identities = 422/780 (54%), Positives = 519/780 (66%), Gaps = 88/780 (11%) Query: 3 EQAGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWAR 62 +Q GPG + G G A G GP A + AG A + QY++PGILH++QHEWAR Sbjct: 20 QQQGPGGNLGLSPGGNGAAGGGGPPA-SEGAGPAAGPELSRPQQYTIPGILHYIQHEWAR 78 Query: 63 FEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 122 FE+ERA WEVERAELQA+IAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG Sbjct: 79 FEMERAHWEVERAELQARIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYG 138 Query: 123 TELNQGDMKPPSYDSDEGNETEVQPQ-QNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSK 181 TELNQGD+K P+++S+E +TE QNSQL WKQGRQLLRQYLQEVGYT Sbjct: 139 TELNQGDLKMPTFESEETKDTEAPTAPQNSQLTWKQGRQLLRQYLQEVGYT--------- 189 Query: 182 RVRALLGFSSDVTDREDDKNQDSVVNGTEAEVKETAMIAKSELTDSASVLDNFKFLESAA 241 D++++ V+ ++ SE S + + L Sbjct: 190 ---------------------DTILDVRSQRVRSLLGLSNSEPNGSVETKNLEQILNGG- 227 Query: 242 ADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFDFLVTSEEGDNES 301 E G+E R + + L+ F+FL +++ D + Sbjct: 228 -------ESPKQKGQEIK-------------------RSSGDVLETFNFLENADDSDED- 260 Query: 302 RSAGDGTDWEKEDQCL-MPEAWNVDQGVITKLKEQYKKERKGKKGVKRPNRSKLQDMLAN 360 E+ D +PE K K + K + G +G+ + + D Sbjct: 261 ---------EENDMIEGIPEG---------KDKHRMNKHKIGNEGLAA-DLTDDPDTEEA 301 Query: 361 LRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGADEALESE 420 L++ D L + + G+ SS + + E +TFP GKSFIMG+D+ L S Sbjct: 302 LKEFDFLVTAEDGEGAGEARSSG-------DGTEWAEPITFPSGGGKSFIMGSDDVLLSV 354 Query: 421 LGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGIRALAFHPIEPVLIT 480 LGLG+LA LTV N+AD +YD+ NKDA RKTWNPK+TLRSHFDG+RALAFHP+EPVL+T Sbjct: 355 LGLGDLADLTVTNDAD-YSYDLPANKDAFRKTWNPKYTLRSHFDGVRALAFHPVEPVLVT 413 Query: 481 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLI 540 ASEDHTLK+WNLQKT PAKKS SLDVEPIYTFRAH GPVL + +SSNGEQC+SGG D I Sbjct: 414 ASEDHTLKLWNLQKTVPAKKSASLDVEPIYTFRAHIGPVLSLAISSNGEQCFSGGIDATI 473 Query: 541 QGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE 600 Q WN +P++DPYD+Y+P+VL G L+GHTDAVWGLAYS +LLSCSADGT+RLWN E Sbjct: 474 QWWNMPSPSVDPYDTYEPNVLAGTLVGHTDAVWGLAYSGIKNQLLSCSADGTVRLWNPQE 533 Query: 601 VAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTT 660 P + +N K+ GIP SVD + DP+HMV SF+ G I+++ET Q ++ L S VD+ Sbjct: 534 KLPCICTYNGDKKHGIPTSVDFIGCDPAHMVTSFNTGSAVIYDLETSQSLVILSSQVDSG 593 Query: 661 ANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLY 720 S+ INRV+SHPTLP++ITAHEDRHIKF+DN TGK+IHSMVAHL+AVTSLAVDPNG+Y Sbjct: 594 LQSNNHINRVVSHPTLPVTITAHEDRHIKFFDNKTGKMIHSMVAHLDAVTSLAVDPNGIY 653 Query: 721 LMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVFV 780 LMSGSHDCSIRLWNL+SKTC+QE TAHRKK +ESI+DVAFH SK YIASAGADALAKVFV Sbjct: 654 LMSGSHDCSIRLWNLDSKTCVQEITAHRKKLDESIYDVAFHSSKAYIASAGADALAKVFV 713 >gi|89886480 zinedin isoform 2 [Homo sapiens] Length = 760 Score = 707 bits (1826), Expect = 0.0 Identities = 397/795 (49%), Positives = 502/795 (63%), Gaps = 77/795 (9%) Query: 5 AGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFE 64 AGPG + P + A G GP + G G+ A SLPGILHF+QHEWARFE Sbjct: 24 AGPGP--TGAAPVSAPAPGPGPAGKGGGGG-GSPGPTAGPEPLSLPGILHFIQHEWARFE 80 Query: 65 VERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTE 124 E+A+WE ERAELQAQ+AFLQGERKGQENLK DLVRRIKMLEYALKQERAKYHKLK+GT+ Sbjct: 81 AEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTD 140 Query: 125 LNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVR 184 LNQG+ K + E +NS L+WK+GRQLLRQYL+EVGYTDTILD++SKRVR Sbjct: 141 LNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVR 200 Query: 185 ALLGFSSDVTDREDDKN---------------QDSVVNGTEAEVKETAMIAKSELTDSAS 229 +LLG S ++ + + +V E ++K A + S Sbjct: 201 SLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGS 260 Query: 230 VLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFD 289 VL FL++ + SDED++ D +K + + + D E+ D+++A+ EFD Sbjct: 261 VLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320 Query: 290 FLVTSEEGD---NESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGV 346 FL + E+G+ + R DG+ E E + Sbjct: 321 FLGSGEDGEGAPDPRRCTVDGSPHELESR------------------------------- 349 Query: 347 KRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSG 406 R KLQ +LA+LRDVD LP P V P P + + HE + S Sbjct: 350 ----RVKLQGILADLRDVDGLP---PKVTGPP-PGTPQPRPHEGSFG----------FSS 391 Query: 407 KSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGI 466 FIM D E+ LG+LA LTV N+ D L+ D++++KDA +KTWNPKFTLRSH+DGI Sbjct: 392 DVFIM--DTIGGGEVSLGDLADLTVTNDND-LSCDLSDSKDAFKKTWNPKFTLRSHYDGI 448 Query: 467 RALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSS 526 R+LAFH + L+TASED TLK+WNLQK AKK+ +LDVEPI+ FRAH+GPVL V M S Sbjct: 449 RSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGS 508 Query: 527 NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLS 586 N E CYSGG D I W + ++DPYD YDPSVL L GH DAVWGLA+S QRL S Sbjct: 509 NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLAS 568 Query: 587 CSADGTLRLWNTTEVAPA-LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME 645 CSADGT+R+W+ + +PA L F E G+P SV S++P+H+VASF G T +++ME Sbjct: 569 CSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDME 628 Query: 646 TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAH 705 +LTLES ++ QIN+V+SHP P++ITAH+DR I+F DN TGK +HSMVAH Sbjct: 629 VGSALLTLESR---GSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAH 685 Query: 706 LEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKC 765 L+AVT LAVDPNG +LMSGSHDCS+RLW+L++KTC+QE TAHRKK EE+IH VA HPSK Sbjct: 686 LDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKA 745 Query: 766 YIASAGADALAKVFV 780 IASAGADALAKVFV Sbjct: 746 LIASAGADALAKVFV 760 >gi|89886477 zinedin isoform 1 [Homo sapiens] Length = 753 Score = 707 bits (1826), Expect = 0.0 Identities = 394/795 (49%), Positives = 499/795 (62%), Gaps = 84/795 (10%) Query: 5 AGPGVFFSNNHPGAGGAKGLGPLAEAAAAGDGAAAAGAARAQYSLPGILHFLQHEWARFE 64 AGPG + P + A G GP + G G+ A SLPGILHF+QHEWARFE Sbjct: 24 AGPGP--TGAAPVSAPAPGPGPAGKGGGGG-GSPGPTAGPEPLSLPGILHFIQHEWARFE 80 Query: 65 VERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKLKYGTE 124 E+A+WE ERAELQAQ+AFLQGERKGQENLK DLVRRIKMLEYALKQERAKYHKLK+GT+ Sbjct: 81 AEKARWEAERAELQAQVAFLQGERKGQENLKTDLVRRIKMLEYALKQERAKYHKLKFGTD 140 Query: 125 LNQGDMKPPSYDSDEGNETEVQPQQNSQLMWKQGRQLLRQYLQEVGYTDTILDVKSKRVR 184 LNQG+ K + E +NS L+WK+GRQLLRQYL+EVGYTDTILD++SKRVR Sbjct: 141 LNQGEKKADVSEQVSNGPVESVTLENSPLVWKEGRQLLRQYLEEVGYTDTILDMRSKRVR 200 Query: 185 ALLGFSSDVTDREDDKN---------------QDSVVNGTEAEVKETAMIAKSELTDSAS 229 +LLG S ++ + + +V E ++K A + S Sbjct: 201 SLLGRSLELNGAVEPSEGAPRAPPGPAGLSGGESLLVKQIEEQIKRNAAGKDGKERLGGS 260 Query: 230 VLDNFKFLESAAADFSDEDEDDDVDGREKSVIDTSTIVRKKALPDSGEDRDTKEALKEFD 289 VL FL++ + SDED++ D +K + + + D E+ D+++A+ EFD Sbjct: 261 VLGQIPFLQNCEDEDSDEDDELDSVQHKKQRVKLPSKALVPEMEDEDEEDDSEDAINEFD 320 Query: 290 FLVTSEEGD---NESRSAGDGTDWEKEDQCLMPEAWNVDQGVITKLKEQYKKERKGKKGV 346 FL + E+G+ + R DG+ E E + Sbjct: 321 FLGSGEDGEGAPDPRRCTVDGSPHELESR------------------------------- 349 Query: 347 KRPNRSKLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSG 406 R KLQ +LA+LRDVD LP P V P + P ++ Sbjct: 350 ----RVKLQGILADLRDVDGLP---PKVTGPPPGTPQPRPHEDV---------------- 386 Query: 407 KSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKFTLRSHFDGI 466 FIM D E+ LG+LA LTV N+ D L+ D++++KDA +KTWNPKFTLRSH+DGI Sbjct: 387 --FIM--DTIGGGEVSLGDLADLTVTNDND-LSCDLSDSKDAFKKTWNPKFTLRSHYDGI 441 Query: 467 RALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSS 526 R+LAFH + L+TASED TLK+WNLQK AKK+ +LDVEPI+ FRAH+GPVL V M S Sbjct: 442 RSLAFHHSQSALLTASEDGTLKLWNLQKAVTAKKNAALDVEPIHAFRAHRGPVLAVAMGS 501 Query: 527 NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLS 586 N E CYSGG D I W + ++DPYD YDPSVL L GH DAVWGLA+S QRL S Sbjct: 502 NSEYCYSGGADACIHSWKIPDLSMDPYDGYDPSVLSHVLEGHGDAVWGLAFSPTSQRLAS 561 Query: 587 CSADGTLRLWNTTEVAPA-LSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNME 645 CSADGT+R+W+ + +PA L F E G+P SV S++P+H+VASF G T +++ME Sbjct: 562 CSADGTVRIWDPSSSSPACLCTFPTASEHGVPTSVAFTSTEPAHIVASFRSGDTVLYDME 621 Query: 646 TQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAH 705 +LTLES ++ QIN+V+SHP P++ITAH+DR I+F DN TGK +HSMVAH Sbjct: 622 VGSALLTLESR---GSSGPTQINQVVSHPNQPLTITAHDDRGIRFLDNRTGKPVHSMVAH 678 Query: 706 LEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKC 765 L+AVT LAVDPNG +LMSGSHDCS+RLW+L++KTC+QE TAHRKK EE+IH VA HPSK Sbjct: 679 LDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDNKTCVQEITAHRKKHEEAIHAVACHPSKA 738 Query: 766 YIASAGADALAKVFV 780 IASAGADALAKVFV Sbjct: 739 LIASAGADALAKVFV 753 >gi|169206451 PREDICTED: similar to hCG1791648 [Homo sapiens] Length = 127 Score = 119 bits (299), Expect = 8e-27 Identities = 61/79 (77%), Positives = 66/79 (83%), Gaps = 1/79 (1%) Query: 60 WARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKL 119 W EV+ AQ + +AQIAFLQGERK QENLKKDLVR+IKMLEYALKQ+RAKYHKL Sbjct: 10 WETGEVQ-AQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYHKL 68 Query: 120 KYGTELNQGDMKPPSYDSD 138 KYG ELNQGDMKPPSYDSD Sbjct: 69 KYGRELNQGDMKPPSYDSD 87 >gi|169205907 PREDICTED: similar to hCG1791648 [Homo sapiens] Length = 127 Score = 119 bits (299), Expect = 8e-27 Identities = 61/79 (77%), Positives = 66/79 (83%), Gaps = 1/79 (1%) Query: 60 WARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKL 119 W EV+ AQ + +AQIAFLQGERK QENLKKDLVR+IKMLEYALKQ+RAKYHKL Sbjct: 10 WETGEVQ-AQSATKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYHKL 68 Query: 120 KYGTELNQGDMKPPSYDSD 138 KYG ELNQGDMKPPSYDSD Sbjct: 69 KYGRELNQGDMKPPSYDSD 87 >gi|169206069 PREDICTED: similar to hCG1791648 [Homo sapiens] Length = 127 Score = 117 bits (293), Expect = 4e-26 Identities = 60/79 (75%), Positives = 65/79 (82%), Gaps = 1/79 (1%) Query: 60 WARFEVERAQWEVERAELQAQIAFLQGERKGQENLKKDLVRRIKMLEYALKQERAKYHKL 119 W EV+ AQ + +AQIAFLQGERK QENLKKDLVR+IKMLEYALKQ+RAKYHKL Sbjct: 10 WETGEVQ-AQSAAKTPSCKAQIAFLQGERKDQENLKKDLVRKIKMLEYALKQKRAKYHKL 68 Query: 120 KYGTELNQGDMKPPSYDSD 138 KYG ELNQGDMKPP YDSD Sbjct: 69 KYGRELNQGDMKPPIYDSD 87 >gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] Length = 357 Score = 84.0 bits (206), Expect = 5e-16 Identities = 71/278 (25%), Positives = 114/278 (41%), Gaps = 29/278 (10%) Query: 508 PIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLG 567 PI H+G V C NG S G D LI WN D+Y L G Sbjct: 58 PIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGD----CDNY------ATLKG 107 Query: 568 HTDAVWGLAYSAAHQRLLSCSADGTLRLWN--TTEVAPALSVFNDTKELGIPASVDLVSS 625 H+ AV L Y+ L S S D T+ +W+ T E L PA Sbjct: 108 HSGAVMELHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPAR-----R 162 Query: 626 DPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHED 685 P + G ++++ + I T ++ Q+ V + T I+ D Sbjct: 163 GPQLVCTGSDDGTVKLWDIRKKAAIQTFQNTY--------QVLAVTFNDTSDQIISGGID 214 Query: 686 RHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLE----SKTCI 741 IK +D KL ++M H ++VT L++ G YL+S + D ++R+W++ + C+ Sbjct: 215 NDIKVWDLRQNKLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCV 274 Query: 742 QEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 + F + FE+++ ++ P IA+ AD V+ Sbjct: 275 KIFQGNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVW 312 Score = 44.3 bits (103), Expect = 4e-04 Identities = 29/137 (21%), Positives = 63/137 (45%), Gaps = 14/137 (10%) Query: 457 FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHK 516 +T+R H D + L+ L++ + D+T+++W+++ AP ++ + ++ F + Sbjct: 229 YTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIFQGNVHNFEKN- 287 Query: 517 GPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLA 576 +L S +G + +G D + W+TT+ I L GH ++ +A Sbjct: 288 --LLRCSWSPDGSKIAAGSADRFVYVWDTTSRRI-----------LYKLPGHAGSINEVA 334 Query: 577 YSAAHQRLLSCSADGTL 593 + ++S S+D L Sbjct: 335 FHPDEPIIISASSDKRL 351 Score = 35.8 bits (81), Expect = 0.16 Identities = 16/37 (43%), Positives = 22/37 (59%) Query: 457 FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQ 493 + L H I +AFHP EP++I+AS D L M +Q Sbjct: 321 YKLPGHAGSINEVAFHPDEPIIISASSDKRLYMGEIQ 357 >gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] Length = 359 Score = 82.8 bits (203), Expect = 1e-15 Identities = 66/283 (23%), Positives = 123/283 (43%), Gaps = 30/283 (10%) Query: 496 APAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS 555 AP + SL+ F+ H+ V CV S N +Q SG D + W+ Sbjct: 3 APCAEDPSLERH----FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK--------- 49 Query: 556 YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELG 615 P GH DAV + +S + L S S D T+R+W V +VF Sbjct: 50 --PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFR--AHTA 104 Query: 616 IPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPT 675 SV S S + AS K ++ Q+ + +L +++ + P Sbjct: 105 TVRSVHFCSDGQSFVTASDDKT-VKVWATHRQKFLFSLSQHINWVRCAKFS-------PD 156 Query: 676 LPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL 735 + ++A +D+ +K +D ++ + +HS H VT + P+G + + D ++++W++ Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216 Query: 736 ESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKV 778 + +Q + H +++ ++FHPS Y+ +A +D+ K+ Sbjct: 217 RTHRLLQHYQLH----SAAVNGLSFHPSGNYLITASSDSTLKI 255 Score = 68.9 bits (167), Expect = 2e-11 Identities = 72/324 (22%), Positives = 124/324 (38%), Gaps = 45/324 (13%) Query: 460 RSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPV 519 + H D + + F L + S D L +W+++ + A Y F HK V Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA-----------YRFTGHKDAV 64 Query: 520 LCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSA 579 CV S +G SG D ++ W PN+ + +V R HT V + + + Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWV---PNVKG----ESTVFRA----HTATVRSVHFCS 113 Query: 580 AHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYT 639 Q ++ S D T+++W T S+ + A FS Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV---------------RCAKFSPDGR 158 Query: 640 SIFNMETQQRILTLESNVDTTANSSCQ----INRVISHPTLPISITAHEDRHIKFYDNNT 695 I + + + + + +S C+ + V HP+ A D +K +D T Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218 Query: 696 GKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESI 755 +L+ H AV L+ P+G YL++ S D ++++ +L + H + Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPA 274 Query: 756 HDVAFHPSKCYIASAGADALAKVF 779 VAF + Y AS G+D V+ Sbjct: 275 TTVAFSRTGEYFASGGSDEQVMVW 298 Score = 68.2 bits (165), Expect = 3e-11 Identities = 60/227 (26%), Positives = 105/227 (46%), Gaps = 24/227 (10%) Query: 557 DPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGI 616 DPS+ R GH DAV + +S ++L S S D L +W+ + P + T G Sbjct: 8 DPSLERH-FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWH---MKPQSRAYRFT---GH 60 Query: 617 PASVDLVSSDPS-HMVASFSKGYTS---IFNMETQQRILTLESNVDTTANSSCQINRVIS 672 +V V+ PS H++AS S+ T + N++ + + + + + C + Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CSDGQSF- 118 Query: 673 HPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRL 732 +TA +D+ +K + + K + S+ H+ V P+G ++S S D +++L Sbjct: 119 -------VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKL 171 Query: 733 WNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 W+ S+ C+ + H + V FHPS IA+AG D KV+ Sbjct: 172 WDKSSRECVHSYCEH----GGFVTYVDFHPSGTCIAAAGMDNTVKVW 214 Score = 62.8 bits (151), Expect = 1e-09 Identities = 64/296 (21%), Positives = 115/296 (38%), Gaps = 38/296 (12%) Query: 443 ANNKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAP 497 + + D+ W+ K + H D + + F P +L + S D T+++W P Sbjct: 36 SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VP 90 Query: 498 AKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYD 557 K S FRAH V V S+G+ + D ++ W T Sbjct: 91 NVKGEST------VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF------- 137 Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIP 617 L H + V +S + ++S S D T++LW+ + V + + G Sbjct: 138 ----LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE---CVHSYCEHGGFV 190 Query: 618 ASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLP 677 VD S + A+ ++++ T + + + + S +N + HP+ Sbjct: 191 TYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLH-------SAAVNGLSFHPSGN 242 Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLW 733 ITA D +K D G+L++++ H T++A G Y SG D + +W Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298 Score = 55.8 bits (133), Expect = 1e-07 Identities = 38/123 (30%), Positives = 54/123 (43%), Gaps = 14/123 (11%) Query: 462 HFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLC 521 H + L+FHP LITAS D TLK+ +L ++ +YT H+GP Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDL-----------MEGRLLYTLHGHQGPATT 276 Query: 522 VVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAH 581 V S GE SGG+D + W + N D D + + + P ++ L S Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKS---NFDIVDHGEVTKVPRPPATLASSMGNLTVSILE 333 Query: 582 QRL 584 QRL Sbjct: 334 QRL 336 >gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] Length = 407 Score = 82.8 bits (203), Expect = 1e-15 Identities = 66/283 (23%), Positives = 123/283 (43%), Gaps = 30/283 (10%) Query: 496 APAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDS 555 AP + SL+ F+ H+ V CV S N +Q SG D + W+ Sbjct: 3 APCAEDPSLERH----FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMK--------- 49 Query: 556 YDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELG 615 P GH DAV + +S + L S S D T+R+W V +VF Sbjct: 50 --PQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTVFR--AHTA 104 Query: 616 IPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPT 675 SV S S + AS K ++ Q+ + +L +++ + P Sbjct: 105 TVRSVHFCSDGQSFVTASDDKT-VKVWATHRQKFLFSLSQHINWVRCAKFS-------PD 156 Query: 676 LPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNL 735 + ++A +D+ +K +D ++ + +HS H VT + P+G + + D ++++W++ Sbjct: 157 GRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDV 216 Query: 736 ESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKV 778 + +Q + H +++ ++FHPS Y+ +A +D+ K+ Sbjct: 217 RTHRLLQHYQLH----SAAVNGLSFHPSGNYLITASSDSTLKI 255 Score = 68.9 bits (167), Expect = 2e-11 Identities = 72/324 (22%), Positives = 124/324 (38%), Gaps = 45/324 (13%) Query: 460 RSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPV 519 + H D + + F L + S D L +W+++ + A Y F HK V Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRA-----------YRFTGHKDAV 64 Query: 520 LCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSA 579 CV S +G SG D ++ W PN+ + +V R HT V + + + Sbjct: 65 TCVNFSPSGHLLASGSRDKTVRIWV---PNVKG----ESTVFRA----HTATVRSVHFCS 113 Query: 580 AHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYT 639 Q ++ S D T+++W T S+ + A FS Sbjct: 114 DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWV---------------RCAKFSPDGR 158 Query: 640 SIFNMETQQRILTLESNVDTTANSSCQ----INRVISHPTLPISITAHEDRHIKFYDNNT 695 I + + + + + +S C+ + V HP+ A D +K +D T Sbjct: 159 LIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRT 218 Query: 696 GKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESI 755 +L+ H AV L+ P+G YL++ S D ++++ +L + H + Sbjct: 219 HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGH----QGPA 274 Query: 756 HDVAFHPSKCYIASAGADALAKVF 779 VAF + Y AS G+D V+ Sbjct: 275 TTVAFSRTGEYFASGGSDEQVMVW 298 Score = 68.2 bits (165), Expect = 3e-11 Identities = 60/227 (26%), Positives = 105/227 (46%), Gaps = 24/227 (10%) Query: 557 DPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGI 616 DPS+ R GH DAV + +S ++L S S D L +W+ + P + T G Sbjct: 8 DPSLERH-FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWH---MKPQSRAYRFT---GH 60 Query: 617 PASVDLVSSDPS-HMVASFSKGYTS---IFNMETQQRILTLESNVDTTANSSCQINRVIS 672 +V V+ PS H++AS S+ T + N++ + + + + + C + Sbjct: 61 KDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF-CSDGQSF- 118 Query: 673 HPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRL 732 +TA +D+ +K + + K + S+ H+ V P+G ++S S D +++L Sbjct: 119 -------VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKL 171 Query: 733 WNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 W+ S+ C+ + H + V FHPS IA+AG D KV+ Sbjct: 172 WDKSSRECVHSYCEH----GGFVTYVDFHPSGTCIAAAGMDNTVKVW 214 Score = 62.8 bits (151), Expect = 1e-09 Identities = 64/296 (21%), Positives = 115/296 (38%), Gaps = 38/296 (12%) Query: 443 ANNKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAP 497 + + D+ W+ K + H D + + F P +L + S D T+++W P Sbjct: 36 SGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-----VP 90 Query: 498 AKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYD 557 K S FRAH V V S+G+ + D ++ W T Sbjct: 91 NVKGEST------VFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKF------- 137 Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIP 617 L H + V +S + ++S S D T++LW+ + V + + G Sbjct: 138 ----LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE---CVHSYCEHGGFV 190 Query: 618 ASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLP 677 VD S + A+ ++++ T + + + + S +N + HP+ Sbjct: 191 TYVDFHPSGTC-IAAAGMDNTVKVWDVRTHRLLQHYQLH-------SAAVNGLSFHPSGN 242 Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLW 733 ITA D +K D G+L++++ H T++A G Y SG D + +W Sbjct: 243 YLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298 Score = 53.1 bits (126), Expect = 9e-07 Identities = 30/90 (33%), Positives = 42/90 (46%), Gaps = 11/90 (12%) Query: 462 HFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLC 521 H + L+FHP LITAS D TLK+ +L ++ +YT H+GP Sbjct: 228 HSAAVNGLSFHPSGNYLITASSDSTLKILDL-----------MEGRLLYTLHGHQGPATT 276 Query: 522 VVMSSNGEQCYSGGTDGLIQGWNTTNPNID 551 V S GE SGG+D + W + +D Sbjct: 277 VAFSRTGEYFASGGSDEQVMVWKSNFDIVD 306 >gi|148536855 coatomer protein complex, subunit alpha isoform 1 [Homo sapiens] Length = 1233 Score = 80.1 bits (196), Expect = 7e-15 Identities = 79/338 (23%), Positives = 136/338 (40%), Gaps = 56/338 (16%) Query: 466 IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMS 525 ++ L+FHP P ++T+ + +++W+ + K F H GPV + Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60 Query: 526 SNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLL 585 SGG D I+ WN Y LLGH D + + + +L Sbjct: 61 KQQPLFVSGGDDYKIKVWN-----------YKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109 Query: 586 SCSADGTLRLWNTTEVAPALSV-----------FNDTKELGIPASVDLVSSDPSHMVASF 634 S S D T+R+WN + F+ T++L + AS+D + ++ Sbjct: 110 SASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLD--QTVRVWDISGL 167 Query: 635 SKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVIS-----------HPTLPISITAH 683 K S +E+ R +T VD + + V+ HPT+P+ ++ Sbjct: 168 RKKNLSPGAVESDVRGIT---GVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGA 224 Query: 684 EDRHIKFYDNNTGKL--IHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCI 741 +DR +K + N K + + H V+ P ++S S D SIR+W++ +T + Sbjct: 225 DDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGV 284 Query: 742 QEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 Q F +F +A HP+ + +AG D VF Sbjct: 285 QTFRRDHDRF----WVLAAHPN-LNLFAAGHDGGMIVF 317 Score = 50.1 bits (118), Expect = 8e-06 Identities = 65/317 (20%), Positives = 111/317 (35%), Gaps = 85/317 (26%) Query: 442 IANNKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTA 496 ++ D K WN K FTL H D IR FH P +++AS+D T+++WN Q Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126 Query: 497 PAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTT---NPNIDP- 552 + H V+C + S D ++ W+ + N+ P Sbjct: 127 -----------CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175 Query: 553 -YDSYDPSVLRGPLLGHTDAV---------WGLAYSAAHQR---LLSCSADGTLRLWNTT 599 +S + L G TDAV G+ ++A H ++S + D +++W Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235 Query: 600 EVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDT 659 E SK + VDT Sbjct: 236 E----------------------------------SKAW-----------------EVDT 244 Query: 660 TANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGL 719 ++ + HP + ++ ED+ I+ +D + + + + LA PN L Sbjct: 245 CRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPN-L 303 Query: 720 YLMSGSHDCSIRLWNLE 736 L + HD + ++ LE Sbjct: 304 NLFAAGHDGGMIVFKLE 320 Score = 37.4 bits (85), Expect = 0.054 Identities = 27/116 (23%), Positives = 46/116 (39%), Gaps = 4/116 (3%) Query: 664 SCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMS 723 S ++ + HP P +T+ + I+ +D LI H V + +S Sbjct: 9 SARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVS 68 Query: 724 GSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 G D I++WN + + C+ H + I FH +I SA D +V+ Sbjct: 69 GGDDYKIKVWNYKLRRCLFTLLGHL----DYIRTTFFHHEYPWILSASDDQTIRVW 120 >gi|148536853 coatomer protein complex, subunit alpha isoform 2 [Homo sapiens] Length = 1224 Score = 80.1 bits (196), Expect = 7e-15 Identities = 79/338 (23%), Positives = 136/338 (40%), Gaps = 56/338 (16%) Query: 466 IRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMS 525 ++ L+FHP P ++T+ + +++W+ + K F H GPV + Sbjct: 12 VKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDK-----------FDEHDGPVRGIDFH 60 Query: 526 SNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLL 585 SGG D I+ WN Y LLGH D + + + +L Sbjct: 61 KQQPLFVSGGDDYKIKVWN-----------YKLRRCLFTLLGHLDYIRTTFFHHEYPWIL 109 Query: 586 SCSADGTLRLWNTTEVAPALSV-----------FNDTKELGIPASVDLVSSDPSHMVASF 634 S S D T+R+WN + F+ T++L + AS+D + ++ Sbjct: 110 SASDDQTIRVWNWQSRTCVCVLTGHNHYVMCAQFHPTEDLVVSASLD--QTVRVWDISGL 167 Query: 635 SKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVIS-----------HPTLPISITAH 683 K S +E+ R +T VD + + V+ HPT+P+ ++ Sbjct: 168 RKKNLSPGAVESDVRGIT---GVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGA 224 Query: 684 EDRHIKFYDNNTGKL--IHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCI 741 +DR +K + N K + + H V+ P ++S S D SIR+W++ +T + Sbjct: 225 DDRQVKIWRMNESKAWEVDTCRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGV 284 Query: 742 QEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 Q F +F +A HP+ + +AG D VF Sbjct: 285 QTFRRDHDRF----WVLAAHPN-LNLFAAGHDGGMIVF 317 Score = 50.1 bits (118), Expect = 8e-06 Identities = 65/317 (20%), Positives = 111/317 (35%), Gaps = 85/317 (26%) Query: 442 IANNKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTA 496 ++ D K WN K FTL H D IR FH P +++AS+D T+++WN Q Sbjct: 67 VSGGDDYKIKVWNYKLRRCLFTLLGHLDYIRTTFFHHEYPWILSASDDQTIRVWNWQSRT 126 Query: 497 PAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTT---NPNIDP- 552 + H V+C + S D ++ W+ + N+ P Sbjct: 127 -----------CVCVLTGHNHYVMCAQFHPTEDLVVSASLDQTVRVWDISGLRKKNLSPG 175 Query: 553 -YDSYDPSVLRGPLLGHTDAV---------WGLAYSAAHQR---LLSCSADGTLRLWNTT 599 +S + L G TDAV G+ ++A H ++S + D +++W Sbjct: 176 AVESDVRGITGVDLFGTTDAVVKHVLEGHDRGVNWAAFHPTMPLIVSGADDRQVKIWRMN 235 Query: 600 EVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDT 659 E SK + VDT Sbjct: 236 E----------------------------------SKAW-----------------EVDT 244 Query: 660 TANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGL 719 ++ + HP + ++ ED+ I+ +D + + + + LA PN L Sbjct: 245 CRGHYNNVSCAVFHPRQELILSNSEDKSIRVWDMSKRTGVQTFRRDHDRFWVLAAHPN-L 303 Query: 720 YLMSGSHDCSIRLWNLE 736 L + HD + ++ LE Sbjct: 304 NLFAAGHDGGMIVFKLE 320 Score = 37.4 bits (85), Expect = 0.054 Identities = 27/116 (23%), Positives = 46/116 (39%), Gaps = 4/116 (3%) Query: 664 SCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMS 723 S ++ + HP P +T+ + I+ +D LI H V + +S Sbjct: 9 SARVKGLSFHPKRPWILTSLHNGVIQLWDYRMCTLIDKFDEHDGPVRGIDFHKQQPLFVS 68 Query: 724 GSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 G D I++WN + + C+ H + I FH +I SA D +V+ Sbjct: 69 GGDDYKIKVWNYKLRRCLFTLLGHL----DYIRTTFFHHEYPWILSASDDQTIRVW 120 >gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib, alpha subunit [Homo sapiens] Length = 410 Score = 79.0 bits (193), Expect = 2e-14 Identities = 78/348 (22%), Positives = 144/348 (41%), Gaps = 51/348 (14%) Query: 451 KTWNP----KFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDV 506 K W P K+ L H + + FHP+ V+++ASED T+K+W+ + + D Sbjct: 92 KEWIPRPPEKYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYE---------TGDF 142 Query: 507 EPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLL 566 E T + H V + +G+ S D I+ W D +R + Sbjct: 143 E--RTLKGHTDSVQDISFDHSGKLLASCSADMTIKLW----------DFQGFECIR-TMH 189 Query: 567 GHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLV-SS 625 GH V +A ++S S D T+++W + + F +E V +V + Sbjct: 190 GHDHNVSSVAIMPNGDHIVSASRDKTIKMWE-VQTGYCVKTFTGHREW-----VRMVRPN 243 Query: 626 DPSHMVASFSKGYT----SIFNMETQQRILTLESNVDTTA----NSSCQINRVISHPTL- 676 ++AS S T + E + + E V+ + +S I+ T Sbjct: 244 QDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESSYSSISEATGSETKK 303 Query: 677 -----PISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIR 731 P ++ D+ IK +D +TG + ++V H V + G +++S + D ++R Sbjct: 304 SGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLR 363 Query: 732 LWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 +W+ ++K C++ AH E + + FH + Y+ + D KV+ Sbjct: 364 VWDYKNKRCMKTLNAH----EHFVTSLDFHKTAPYVVTGSVDQTVKVW 407 >gi|32189425 WD repeat domain 69 [Homo sapiens] Length = 415 Score = 79.0 bits (193), Expect = 2e-14 Identities = 61/277 (22%), Positives = 120/277 (43%), Gaps = 35/277 (12%) Query: 458 TLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKG 517 T R H I L+F+P ++ T S D T K+W++Q E +YT R H Sbjct: 172 TFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNG-----------EEVYTLRGHSA 220 Query: 518 PVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAY 577 ++ + +++G++ +G D + W+ D L+GH + ++ Sbjct: 221 EIISLSFNTSGDRIITGSFDHTVVVWDA-----------DTGRKVNILIGHCAEISSASF 269 Query: 578 SAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSK- 636 + +L+ S D T +LW+ T ++ E+ +D ++A+ S Sbjct: 270 NWDCSLILTGSMDKTCKLWDATNGKCVATLTGHDDEI-----LDSCFDYTGKLIATASAD 324 Query: 637 GYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTG 696 G IF+ T++ I LE + +I+++ +P +T D+ + +D TG Sbjct: 325 GTARIFSAATRKCIAKLEGHEG-------EISKISFNPQGNHLLTGSSDKTARIWDAQTG 377 Query: 697 KLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLW 733 + + + H + + S A + G +++GS D + R+W Sbjct: 378 QCLQVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414 Score = 67.4 bits (163), Expect = 5e-11 Identities = 65/305 (21%), Positives = 138/305 (45%), Gaps = 31/305 (10%) Query: 478 LITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTD 537 L+TAS +K+ + ++++ +AH P+ V ++ +G +G D Sbjct: 54 LLTASRTEQVKLLIQRLQEKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYD 113 Query: 538 GLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAH-QRLLSCSADGTLRLW 596 + W+T + L GH + V+ +A++ + ++ + S D T +LW Sbjct: 114 RTCKLWDTASGEE-----------LNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW 162 Query: 597 NTTEVAPALSVFNDTKELGIPASVDLVSSDP-SHMVASFSKGYTS-IFNMETQQRILTLE 654 + E F G A + +S +P S +VA+ S T+ +++++ + + TL Sbjct: 163 SV-ETGKCYHTFR-----GHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216 Query: 655 SNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAV 714 + S +I + + + IT D + +D +TG+ ++ ++ H ++S + Sbjct: 217 GH-------SAEIISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASF 269 Query: 715 DPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADA 774 + + +++GS D + +LW+ + C+ T H ++ I D F + IA+A AD Sbjct: 270 NWDCSLILTGSMDKTCKLWDATNGKCVATLTGH----DDEILDSCFDYTGKLIATASADG 325 Query: 775 LAKVF 779 A++F Sbjct: 326 TARIF 330 Score = 66.6 bits (161), Expect = 8e-11 Identities = 62/323 (19%), Positives = 131/323 (40%), Gaps = 38/323 (11%) Query: 458 TLRSHFDGIRALAFH-PIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHK 516 TL H + + A+AF+ P + T S D T K+W+++ + +TFR H Sbjct: 129 TLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG-----------KCYHTFRGHT 177 Query: 517 GPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLA 576 ++C+ + +G D + W+ N + Y L GH+ + L+ Sbjct: 178 AEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGE----EVYT-------LRGHSAEIISLS 226 Query: 577 YSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSK 636 ++ + R+++ S D T+ +W+ + E+ + + D S ++ Sbjct: 227 FNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSAS----FNWDCSLILTGSMD 282 Query: 637 GYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTG 696 +++ + + TL + D +S T + TA D + + T Sbjct: 283 KTCKLWDATNGKCVATLTGHDDEILDSCFDY-------TGKLIATASADGTARIFSAATR 335 Query: 697 KLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIH 756 K I + H ++ ++ +P G +L++GS D + R+W+ ++ C+Q H + I Sbjct: 336 KCIAKLEGHEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGH----TDEIF 391 Query: 757 DVAFHPSKCYIASAGADALAKVF 779 AF+ + + D +++ Sbjct: 392 SCAFNYKGNIVITGSKDNTCRIW 414 Score = 59.3 bits (142), Expect = 1e-08 Identities = 72/398 (18%), Positives = 157/398 (39%), Gaps = 51/398 (12%) Query: 387 EHEINRADEVEALTFPPSSGKSFIMGADEALESELGLGELAGLTVANEADSLTYDIANNK 446 +H + ++ L PS+ S AL E+ E L A+ + + I + Sbjct: 21 KHGELKTKSIDLLDLGPSTDVS-------ALVEEIQKAE--PLLTASRTEQVKLLIQRLQ 71 Query: 447 DALRKTWNPKF----TLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKST 502 + L + N F L++H + +A + IT S D T K+W+ Sbjct: 72 EKLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD----------- 120 Query: 503 SLDVEPIYTFRAHKGPVLCVVMSS-NGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVL 561 + E + T H+ V + ++ G++ +G D + W S + Sbjct: 121 TASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLW-----------SVETGKC 169 Query: 562 RGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVD 621 GHT + L+++ + + S D T +LW+ ++ + E+ S+ Sbjct: 170 YHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVYTLRGHSAEI---ISLS 226 Query: 622 LVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISIT 681 +S + SF +++ +T +++ L + +++S + + +T Sbjct: 227 FNTSGDRIITGSFDHTVV-VWDADTGRKVNILIGHCAEISSASFNWD-------CSLILT 278 Query: 682 AHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCI 741 D+ K +D GK + ++ H + + D G + + S D + R+++ ++ CI Sbjct: 279 GSMDKTCKLWDATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCI 338 Query: 742 QEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 + H E I ++F+P ++ + +D A+++ Sbjct: 339 AKLEGH----EGEISKISFNPQGNHLLTGSSDKTARIW 372 Score = 43.1 bits (100), Expect = 0.001 Identities = 50/229 (21%), Positives = 90/229 (39%), Gaps = 37/229 (16%) Query: 447 DALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKS 501 D K W+ + +TLR H I +L+F+ +IT S DHT+ +W+ A + Sbjct: 198 DTTAKLWDIQNGEEVYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVWD----ADTGRK 253 Query: 502 TSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVL 561 ++ + H + + + +G D + W+ TN Sbjct: 254 VNILI-------GHCAEISSASFNWDCSLILTGSMDKTCKLWDATN-----------GKC 295 Query: 562 RGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVD 621 L GH D + + + + + SADGT R+++ A + K G + Sbjct: 296 VATLTGHDDEILDSCFDYTGKLIATASADGTARIFS------AATRKCIAKLEGHEGEIS 349 Query: 622 LVSSDP--SHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQIN 668 +S +P +H++ S I++ +T Q + LE + D SC N Sbjct: 350 KISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEI--FSCAFN 396 >gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo sapiens] Length = 514 Score = 76.3 bits (186), Expect = 1e-13 Identities = 83/378 (21%), Positives = 146/378 (38%), Gaps = 61/378 (16%) Query: 428 GLTVANEADSLTYDIANNKDALRKTW-------NPKFTLRSHFDGIRALAFHPIEPVLIT 480 G AN ++ + IANN + + N LR H + A++P+ +L + Sbjct: 127 GENTANGEENGAHTIANNHTDMMEVDGDVEIPPNKAVVLRGHESEVFICAWNPVSDLLAS 186 Query: 481 ASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKG--------PVLCVVMSSNGEQCY 532 S D T ++WNL ++ STS + + +G V + +S G Sbjct: 187 GSGDSTARIWNL-----SENSTSGSTQLVLRHCIREGGQDVPSNKDVTSLDWNSEGTLLA 241 Query: 533 SGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGT 592 +G DG + W T + N L L H ++ L ++ +LS D T Sbjct: 242 TGSYDGFARIW-TKDGN-----------LASTLGQHKGPIFALKWNKKGNFILSAGVDKT 289 Query: 593 LRLWNT-TEVAPALSVFNDTKELGIP-ASVDLVSSDPSHMVASFSKGYTSIFNMETQQRI 650 +W+ T A F+ L + S + +S + M K Sbjct: 290 TIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCK-------------- 335 Query: 651 LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVT 710 L + + T + ++N + PT + + +D +K + +H + AH + + Sbjct: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDNCVHDLQAHNKEIY 395 Query: 711 SLAVDPNG---------LYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFH 761 ++ P G L L S S D ++RLW+++ CI T H +E ++ VAF Sbjct: 396 TIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKH----QEPVYSVAFS 451 Query: 762 PSKCYIASAGADALAKVF 779 P Y+AS D ++ Sbjct: 452 PDGRYLASGSFDKCVHIW 469 >gi|5174447 guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1 [Homo sapiens] Length = 317 Score = 75.9 bits (185), Expect = 1e-13 Identities = 71/287 (24%), Positives = 127/287 (44%), Gaps = 28/287 (9%) Query: 458 TLRSHFDGIRALAFHPIEP-VLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHK 516 TL+ H + +A P P ++++AS D T+ MW L + T+ + P R H Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKL-----TRDETNYGI-PQRALRGHS 63 Query: 517 GPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLA 576 V VV+SS+G+ SG DG ++ W+ T +GHT V +A Sbjct: 64 HFVSDVVISSDGQFALSGSWDGTLRLWDLTT-----------GTTTRRFVGHTKDVLSVA 112 Query: 577 YSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSK 636 +S+ +++++S S D T++LWNT V E SS+P + + K Sbjct: 113 FSSDNRQIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDK 172 Query: 637 GYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTG 696 ++N+ L++N + +N V P + + +D +D N G Sbjct: 173 -LVKVWNLAN----CKLKTN---HIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEG 224 Query: 697 KLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQE 743 K ++++ + + +L PN +L + + SI++W+LE K + E Sbjct: 225 KHLYTLDGG-DIINALCFSPNRYWLCAATGP-SIKIWDLEGKIIVDE 269 Score = 46.6 bits (109), Expect = 9e-05 Identities = 54/222 (24%), Positives = 82/222 (36%), Gaps = 54/222 (24%) Query: 561 LRGPLLGHTDAVWGLAYSAAH-QRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPAS 619 LRG L GH V +A + +LS S D T+ +W T D GIP Sbjct: 7 LRGTLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTR---------DETNYGIP-- 55 Query: 620 VDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPIS 679 QR L S+ ++ V+ + Sbjct: 56 ----------------------------QRALRGHSHF---------VSDVVISSDGQFA 78 Query: 680 ITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKT 739 ++ D ++ +D TG V H + V S+A + ++SGS D +I+LWN Sbjct: 79 LSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWNTLG-- 136 Query: 740 CIQEFTAHRKKFEESIHDVAFHP--SKCYIASAGADALAKVF 779 + ++T + E + V F P S I S G D L KV+ Sbjct: 137 -VCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVW 177 >gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [Homo sapiens] Length = 514 Score = 73.6 bits (179), Expect = 7e-13 Identities = 82/338 (24%), Positives = 137/338 (40%), Gaps = 49/338 (14%) Query: 453 WNPKFTL----RSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEP 508 W+P + L H +R +A P +T S D T+K+W+L A K SL Sbjct: 190 WHPPWKLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDL---ASGKLKLSL---- 242 Query: 509 IYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTT-NPNIDPYDSYDPSVLRGPLLG 567 H V V++S+ +S G D ++ W+ N I Y G Sbjct: 243 ----TGHISTVRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYH------------G 286 Query: 568 HTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDP 627 H AV+GL L++CS D T R+W+ A ++ T + A+V +++P Sbjct: 287 HLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLSGHTNAV---ATVRCQAAEP 343 Query: 628 SHMVASFSKGYTSIFNMETQQRILTLESNVD--TTANSSCQINRVISHPTLPISITAHED 685 + S +T R+ L + T N + V+ HP + D Sbjct: 344 QIITGSH----------DTTIRLWDLVAGKTRVTLTNHKKSVRAVVLHPRHYTFASGSPD 393 Query: 686 RHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFT 745 +IK + G I ++ H + +L V+ +G+ L+SG+ + ++ LW+ + Q Sbjct: 394 -NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGV-LVSGADNGTMHLWDWRTGYNFQRVH 451 Query: 746 AHRK----KFEESIHDVAFHPSKCYIASAGADALAKVF 779 A + E I AF S+ + +A AD KV+ Sbjct: 452 AAVQPGSLDSESGIFACAFDQSESRLLTAEADKTIKVY 489 Score = 37.4 bits (85), Expect = 0.054 Identities = 25/110 (22%), Positives = 43/110 (39%), Gaps = 16/110 (14%) Query: 440 YDIANNKDALRKTWNPKFT-----LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQK 494 Y + +D K W+ ++ H + L HP VL+T S D T ++W+++ Sbjct: 260 YLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRT 319 Query: 495 TAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWN 544 A ++T H V V + Q +G D I+ W+ Sbjct: 320 KA-----------SVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWD 358 Score = 37.0 bits (84), Expect = 0.070 Identities = 39/158 (24%), Positives = 66/158 (41%), Gaps = 29/158 (18%) Query: 445 NKDALRKTWNPK-----FTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAK 499 ++D+ + W+ + TL H + + + EP +IT S D T+++W+L A Sbjct: 307 SRDSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDL----VAG 362 Query: 500 KSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPS 559 K+ T HK V VV+ SG D NI + D S Sbjct: 363 KTR-------VTLTNHKKSVRAVVLHPRHYTFASGSPD-----------NIKQWKFPDGS 404 Query: 560 VLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 597 ++ L GH + L + + L+S + +GT+ LW+ Sbjct: 405 FIQN-LSGHNAIINTLTVN-SDGVLVSGADNGTMHLWD 440 >gi|26665869 WD repeat domain 51B [Homo sapiens] Length = 478 Score = 73.6 bits (179), Expect = 7e-13 Identities = 80/329 (24%), Positives = 132/329 (40%), Gaps = 50/329 (15%) Query: 447 DALRKTWNPKFTLRS-----HFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKS 501 D WN K R+ H D + ++ F P +L +AS D T+++W P K+ Sbjct: 39 DTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLW-----IPDKRG 93 Query: 502 TSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVL 561 + F+AH PV V S++G+ + D I+ W+ Y L Sbjct: 94 KFSE------FKAHTAPVRSVDFSADGQFLATASEDKSIKVWSM----------YRQRFL 137 Query: 562 RGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVD 621 L HT V +S + ++SCS D T+++W+TT V N + +G VD Sbjct: 138 YS-LYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQ---CVNNFSDSVGFANFVD 193 Query: 622 LVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANS----SCQINRVISHPTLP 677 F+ T I + + Q + + V+ S +N + HP+ Sbjct: 194 ------------FNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCISFHPSGN 241 Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLW--NL 735 ITA D +K D G+LI+++ H V +++ G SG D + LW N Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNF 301 Query: 736 ESKTC--IQEFTAHRKKFEESIHDVAFHP 762 + C + + R F+ H + +P Sbjct: 302 DELHCKGLTKRNLKRLHFDSPPHLLDIYP 330 Score = 73.2 bits (178), Expect = 9e-13 Identities = 56/268 (20%), Positives = 112/268 (41%), Gaps = 28/268 (10%) Query: 512 FRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDA 571 F+ HK + + +S NG+Q + D + WN + P +GH D Sbjct: 14 FKGHKAAITSLDLSPNGKQLATASWDTFLMLWN-----------FKPHARAYRYVGHKDV 62 Query: 572 VWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPA-SVDLVSSDPSHM 630 V + +S L S S D T+RLW + F++ K P SVD S+D + Sbjct: 63 VTSVQFSPHGNLLASASRDRTVRLW----IPDKRGKFSEFKAHTAPVRSVDF-SADGQFL 117 Query: 631 VASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKF 690 + +++M Q+ + +L + + P + ++ ED+ IK Sbjct: 118 ATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFS-------PDGRLIVSCSEDKTIKI 170 Query: 691 YDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKK 750 +D + +++ + + +P+G + S D ++++W++ +Q + H Sbjct: 171 WDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVH--- 227 Query: 751 FEESIHDVAFHPSKCYIASAGADALAKV 778 ++ ++FHPS Y+ +A +D K+ Sbjct: 228 -SGGVNCISFHPSGNYLITASSDGTLKI 254 Score = 43.5 bits (101), Expect = 8e-04 Identities = 28/99 (28%), Positives = 44/99 (44%), Gaps = 4/99 (4%) Query: 681 TAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTC 740 TA D + ++ + V H + VTS+ P+G L S S D ++RLW + + Sbjct: 35 TASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVRLWIPDKRGK 94 Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 EF AH + V F ++A+A D KV+ Sbjct: 95 FSEFKAH----TAPVRSVDFSADGQFLATASEDKSIKVW 129 Score = 41.6 bits (96), Expect = 0.003 Identities = 22/76 (28%), Positives = 36/76 (47%), Gaps = 4/76 (5%) Query: 705 HLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSK 764 H A+TSL + PNG L + S D + LWN + + H+ + + V F P Sbjct: 17 HKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHK----DVVTSVQFSPHG 72 Query: 765 CYIASAGADALAKVFV 780 +ASA D ++++ Sbjct: 73 NLLASASRDRTVRLWI 88 >gi|21071067 TBP-associated factor 5 [Homo sapiens] Length = 800 Score = 72.4 bits (176), Expect = 2e-12 Identities = 52/219 (23%), Positives = 90/219 (41%), Gaps = 30/219 (13%) Query: 440 YDIANNKDALRKTW-----NPKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQK 494 Y ++ D + + W P H + FHP + T S D T+++W++ Sbjct: 599 YFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDV-- 656 Query: 495 TAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYD 554 L+ + F HKGP+ + S NG +G TDG + W+ + Sbjct: 657 ---------LNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGH------- 700 Query: 555 SYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKEL 614 ++ G L GHTD V L +S + L S S D T+RLW+ + L + T Sbjct: 701 ----GLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWDAIKAFEDLETDDFTTAT 756 Query: 615 GIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTL 653 G ++L + ++ ++ T + ++ +R L L Sbjct: 757 G---HINLPENSQELLLGTYMTKSTPVVHLHFTRRNLVL 792 Score = 56.2 bits (134), Expect = 1e-07 Identities = 42/183 (22%), Positives = 70/183 (38%), Gaps = 11/183 (6%) Query: 565 LLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVS 624 L GH+ V+G ++S LLS S DGT+RLW+ + K P S Sbjct: 539 LYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGY----KGHNYPVWDTQFS 594 Query: 625 SDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHE 684 + V+ ++ + Q + ++ +N HP T Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHL-------ADVNCTRFHPNSNYVATGSA 647 Query: 685 DRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEF 744 DR ++ +D G + H + SL PNG +L +G+ D + LW++ + E Sbjct: 648 DRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGEL 707 Query: 745 TAH 747 H Sbjct: 708 KGH 710 Score = 52.0 bits (123), Expect = 2e-06 Identities = 81/364 (22%), Positives = 126/364 (34%), Gaps = 49/364 (13%) Query: 377 PSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMGAD--EALESELGLGELAGLTVANE 434 P+ P +R+P E+ +D+++ + + K +G D ++ L GLT + Sbjct: 419 PNAPPQNRIPLPELKDSDKLDKIMNMKETTKRVRLGPDCLPSICFYTFLNAYQGLTAVDV 478 Query: 435 ADSLTYDIANNKDALRKTWN--PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNL 492 D + D+ + W+ PK LRS + LI D L+ Sbjct: 479 TDDSSLIAGGFADSTVRVWSVTPK-KLRS--------VKQASDLSLIDKESDDVLERIMD 529 Query: 493 QKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDP 552 +KTA K H GPV S + S DG ++ W Sbjct: 530 EKTASELK----------ILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW--------- 570 Query: 553 YDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTK 612 S GH VW +S +S D RLW T P L +F Sbjct: 571 --SLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQP-LRIF---- 623 Query: 613 ELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRIL-TLESN-VDTTANSSCQINRV 670 G A V+ P+ Y + + + R+ L N V I+ + Sbjct: 624 -AGHLADVNCTRFHPN-------SNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSL 675 Query: 671 ISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSI 730 P T D + +D G ++ + H + V SL +G L SGS D ++ Sbjct: 676 TFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTV 735 Query: 731 RLWN 734 RLW+ Sbjct: 736 RLWD 739 Score = 48.5 bits (114), Expect = 2e-05 Identities = 25/91 (27%), Positives = 43/91 (47%), Gaps = 4/91 (4%) Query: 689 KFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHR 748 + D T + + H V + P+ YL+S S D ++RLW+L++ TC+ + H Sbjct: 526 RIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGH- 584 Query: 749 KKFEESIHDVAFHPSKCYIASAGADALAKVF 779 + D F P Y S G D +A+++ Sbjct: 585 ---NYPVWDTQFSPYGYYFVSGGHDRVARLW 612 Score = 48.5 bits (114), Expect = 2e-05 Identities = 24/94 (25%), Positives = 46/94 (48%), Gaps = 4/94 (4%) Query: 680 ITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKT 739 ++ DR + + + + + HL V PN Y+ +GS D ++RLW++ + Sbjct: 601 VSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN 660 Query: 740 CIQEFTAHRKKFEESIHDVAFHPSKCYIASAGAD 773 C++ FT H+ IH + F P+ ++A+ D Sbjct: 661 CVRIFTGHK----GPIHSLTFSPNGRFLATGATD 690 Score = 43.5 bits (101), Expect = 8e-04 Identities = 24/100 (24%), Positives = 43/100 (43%), Gaps = 4/100 (4%) Query: 680 ITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKT 739 +++ ED ++ + T + H V P G Y +SG HD RLW + Sbjct: 559 LSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQ 618 Query: 740 CIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 ++ F H ++ FHP+ Y+A+ AD +++ Sbjct: 619 PLRIFAGHL----ADVNCTRFHPNSNYVATGSADRTVRLW 654 >gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] Length = 526 Score = 72.4 bits (176), Expect = 2e-12 Identities = 73/339 (21%), Positives = 129/339 (38%), Gaps = 52/339 (15%) Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP 518 LR H + A++P+ +L + S D T ++WNL + + ST L + H P Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREGGHDVP 235 Query: 519 ----VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWG 574 V + ++NG +G DG + W + L L H ++ Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 283 Query: 575 LAYSAAHQRLLSCSADGTLRLWNT-TEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633 L ++ +LS D T +W+ T A F+ L + Sbjct: 284 LKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--------------- 328 Query: 634 FSKGYTSIFNMETQQRI----LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIK 689 + T+ + T I L + V T + ++N + P+ + + +D +K Sbjct: 329 --QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK 386 Query: 690 FYDNNTGKLIHSMVAHLEAVTSLAVDPNG---------LYLMSGSHDCSIRLWNLESKTC 740 + IH + AH + + ++ P G + L S S D ++RLW++E C Sbjct: 387 IWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 446 Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 T H +E ++ VAF P Y+AS D ++ Sbjct: 447 THTLTKH----QEPVYSVAFSPDGKYLASGSFDKCVHIW 481 Score = 45.4 bits (106), Expect = 2e-04 Identities = 57/274 (20%), Positives = 107/274 (39%), Gaps = 56/274 (20%) Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE----VAPALSVFNDTKE 613 PS L GH V+ A++ L S S D T R+WN E + L + + +E Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229 Query: 614 LG--IPASVDLVSSD----------------------PSHMVASFSKGYTSIFNMETQQR 649 G +P++ D+ S D ++ ++ + IF ++ ++ Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 289 Query: 650 -ILTLESNVDTT-------ANSSCQINRVISHPTLPIS-------ITAHEDRHIKFYDNN 694 L + VD T + Q S P L + + D I Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 349 Query: 695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEES 754 + + + H V ++ DP+G+ L S S D ++++W+++ + CI + AH K+ Sbjct: 350 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKE---- 405 Query: 755 IHDVAFHP---------SKCYIASAGADALAKVF 779 I+ + + P S +ASA D+ +++ Sbjct: 406 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439 >gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] Length = 526 Score = 72.4 bits (176), Expect = 2e-12 Identities = 73/339 (21%), Positives = 129/339 (38%), Gaps = 52/339 (15%) Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP 518 LR H + A++P+ +L + S D T ++WNL + + ST L + H P Sbjct: 177 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREGGHDVP 235 Query: 519 ----VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWG 574 V + ++NG +G DG + W + L L H ++ Sbjct: 236 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 283 Query: 575 LAYSAAHQRLLSCSADGTLRLWNT-TEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633 L ++ +LS D T +W+ T A F+ L + Sbjct: 284 LKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--------------- 328 Query: 634 FSKGYTSIFNMETQQRI----LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIK 689 + T+ + T I L + V T + ++N + P+ + + +D +K Sbjct: 329 --QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK 386 Query: 690 FYDNNTGKLIHSMVAHLEAVTSLAVDPNG---------LYLMSGSHDCSIRLWNLESKTC 740 + IH + AH + + ++ P G + L S S D ++RLW++E C Sbjct: 387 IWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 446 Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 T H +E ++ VAF P Y+AS D ++ Sbjct: 447 THTLTKH----QEPVYSVAFSPDGKYLASGSFDKCVHIW 481 Score = 45.4 bits (106), Expect = 2e-04 Identities = 57/274 (20%), Positives = 107/274 (39%), Gaps = 56/274 (20%) Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE----VAPALSVFNDTKE 613 PS L GH V+ A++ L S S D T R+WN E + L + + +E Sbjct: 170 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 229 Query: 614 LG--IPASVDLVSSD----------------------PSHMVASFSKGYTSIFNMETQQR 649 G +P++ D+ S D ++ ++ + IF ++ ++ Sbjct: 230 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 289 Query: 650 -ILTLESNVDTT-------ANSSCQINRVISHPTLPIS-------ITAHEDRHIKFYDNN 694 L + VD T + Q S P L + + D I Sbjct: 290 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 349 Query: 695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEES 754 + + + H V ++ DP+G+ L S S D ++++W+++ + CI + AH K+ Sbjct: 350 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKE---- 405 Query: 755 IHDVAFHP---------SKCYIASAGADALAKVF 779 I+ + + P S +ASA D+ +++ Sbjct: 406 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 439 >gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] Length = 577 Score = 72.4 bits (176), Expect = 2e-12 Identities = 73/339 (21%), Positives = 129/339 (38%), Gaps = 52/339 (15%) Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP 518 LR H + A++P+ +L + S D T ++WNL + + ST L + H P Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREGGHDVP 286 Query: 519 ----VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWG 574 V + ++NG +G DG + W + L L H ++ Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 334 Query: 575 LAYSAAHQRLLSCSADGTLRLWNT-TEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633 L ++ +LS D T +W+ T A F+ L + Sbjct: 335 LKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--------------- 379 Query: 634 FSKGYTSIFNMETQQRI----LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIK 689 + T+ + T I L + V T + ++N + P+ + + +D +K Sbjct: 380 --QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK 437 Query: 690 FYDNNTGKLIHSMVAHLEAVTSLAVDPNG---------LYLMSGSHDCSIRLWNLESKTC 740 + IH + AH + + ++ P G + L S S D ++RLW++E C Sbjct: 438 IWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 497 Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 T H +E ++ VAF P Y+AS D ++ Sbjct: 498 THTLTKH----QEPVYSVAFSPDGKYLASGSFDKCVHIW 532 Score = 45.4 bits (106), Expect = 2e-04 Identities = 57/274 (20%), Positives = 107/274 (39%), Gaps = 56/274 (20%) Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE----VAPALSVFNDTKE 613 PS L GH V+ A++ L S S D T R+WN E + L + + +E Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280 Query: 614 LG--IPASVDLVSSD----------------------PSHMVASFSKGYTSIFNMETQQR 649 G +P++ D+ S D ++ ++ + IF ++ ++ Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 340 Query: 650 -ILTLESNVDTT-------ANSSCQINRVISHPTLPIS-------ITAHEDRHIKFYDNN 694 L + VD T + Q S P L + + D I Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 400 Query: 695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEES 754 + + + H V ++ DP+G+ L S S D ++++W+++ + CI + AH K+ Sbjct: 401 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKE---- 456 Query: 755 IHDVAFHP---------SKCYIASAGADALAKVF 779 I+ + + P S +ASA D+ +++ Sbjct: 457 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490 >gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] Length = 577 Score = 72.4 bits (176), Expect = 2e-12 Identities = 73/339 (21%), Positives = 129/339 (38%), Gaps = 52/339 (15%) Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGP 518 LR H + A++P+ +L + S D T ++WNL + + ST L + H P Sbjct: 228 LRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGG-STQLVLRHCIREGGHDVP 286 Query: 519 ----VLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWG 574 V + ++NG +G DG + W + L L H ++ Sbjct: 287 SNKDVTSLDWNTNGTLLATGSYDGFARIWT------------EDGNLASTLGQHKGPIFA 334 Query: 575 LAYSAAHQRLLSCSADGTLRLWNT-TEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633 L ++ +LS D T +W+ T A F+ L + Sbjct: 335 LKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDW--------------- 379 Query: 634 FSKGYTSIFNMETQQRI----LTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIK 689 + T+ + T I L + V T + ++N + P+ + + +D +K Sbjct: 380 --QNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLK 437 Query: 690 FYDNNTGKLIHSMVAHLEAVTSLAVDPNG---------LYLMSGSHDCSIRLWNLESKTC 740 + IH + AH + + ++ P G + L S S D ++RLW++E C Sbjct: 438 IWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVC 497 Query: 741 IQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 T H +E ++ VAF P Y+AS D ++ Sbjct: 498 THTLTKH----QEPVYSVAFSPDGKYLASGSFDKCVHIW 532 Score = 45.4 bits (106), Expect = 2e-04 Identities = 57/274 (20%), Positives = 107/274 (39%), Gaps = 56/274 (20%) Query: 558 PSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTE----VAPALSVFNDTKE 613 PS L GH V+ A++ L S S D T R+WN E + L + + +E Sbjct: 221 PSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIRE 280 Query: 614 LG--IPASVDLVSSD----------------------PSHMVASFSKGYTSIFNMETQQR 649 G +P++ D+ S D ++ ++ + IF ++ ++ Sbjct: 281 GGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRK 340 Query: 650 -ILTLESNVDTT-------ANSSCQINRVISHPTLPIS-------ITAHEDRHIKFYDNN 694 L + VD T + Q S P L + + D I Sbjct: 341 GNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLG 400 Query: 695 TGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEES 754 + + + H V ++ DP+G+ L S S D ++++W+++ + CI + AH K+ Sbjct: 401 CDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKE---- 456 Query: 755 IHDVAFHP---------SKCYIASAGADALAKVF 779 I+ + + P S +ASA D+ +++ Sbjct: 457 IYTIKWSPTGPATSNPNSNIMLASASFDSTVRLW 490 >gi|16554629 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 71.6 bits (174), Expect = 3e-12 Identities = 73/323 (22%), Positives = 136/323 (42%), Gaps = 43/323 (13%) Query: 456 KFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAH 515 KFTL H + ++ F P L ++S D +K+W + D + T H Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFEKTISGH 86 Query: 516 KGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGL 575 K + V SS+ S D ++ W+ ++ L GH++ V+ Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC-----------LKTLKGHSNYVFCC 135 Query: 576 AYSAAHQRLLSCSADGTLRLWN--TTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633 ++ ++S S D ++R+W+ T + L +D P S + D S +V+S Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD------PVSAVHFNRDGSLIVSS 189 Query: 634 FSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDN 693 G I++ + Q + TL +D + + ++ V P + A D +K +D Sbjct: 190 SYDGLCRIWDTASGQCLKTL---ID---DDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243 Query: 694 NTGKLIHSMVAHLEAVTSLAVD---PNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKK 750 + GK + + H + + G +++SGS D + +WNL++K +Q+ H Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH--- 300 Query: 751 FEESIHDVAFHPSKCYIASAGAD 773 + + A HP++ IASA + Sbjct: 301 -TDVVISTACHPTENIIASAALE 322 Score = 62.8 bits (151), Expect = 1e-09 Identities = 63/263 (23%), Positives = 118/263 (44%), Gaps = 31/263 (11%) Query: 495 TAPAKKSTSLDVEPIY----TFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNI 550 ++ A +S V+P Y T H V V S NGE S D LI+ W Sbjct: 20 SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----- 74 Query: 551 DPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFND 610 YD + G LG +D W S+ L+S S D TL++W+ + L Sbjct: 75 --YDGKFEKTISGHKLGISDVAW----SSDSNLLVSASDDKTLKIWDVSS-GKCLKTLK- 126 Query: 611 TKELGIPASVDLVSSDP-SHMVASFSKGYT-SIFNMETQQRILTLESNVDTTANSSCQIN 668 G V + +P S+++ S S + I++++T + + TL ++ D S+ N Sbjct: 127 ----GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV--SAVHFN 180 Query: 669 RVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEA-VTSLAVDPNGLYLMSGSHD 727 R S + +++ D + +D +G+ + +++ V+ + PNG Y+++ + D Sbjct: 181 RDGS-----LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD 235 Query: 728 CSIRLWNLESKTCIQEFTAHRKK 750 +++LW+ C++ +T H+ + Sbjct: 236 NTLKLWDYSKGKCLKTYTGHKNE 258 Score = 62.4 bits (150), Expect = 2e-09 Identities = 56/222 (25%), Positives = 105/222 (47%), Gaps = 20/222 (9%) Query: 561 LRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASV 620 L+ L GHT AV + +S + L S SAD +++W + ++ +LGI Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH--KLGIS--- 91 Query: 621 DLVSSDPSHMVASFSKGYT-SIFNMETQQRILTLE--SNVDTTANSSCQINRVISHPTLP 677 D+ S S+++ S S T I+++ + + + TL+ SN N + Q N ++S Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS----- 146 Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737 D ++ +D TGK + ++ AH + V+++ + +G ++S S+D R+W+ S Sbjct: 147 ----GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 Query: 738 KTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 C++ + V F P+ YI +A D K++ Sbjct: 203 GQCLKTLI---DDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 >gi|16554627 WD repeat domain 5 [Homo sapiens] Length = 334 Score = 71.6 bits (174), Expect = 3e-12 Identities = 73/323 (22%), Positives = 136/323 (42%), Gaps = 43/323 (13%) Query: 456 KFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAH 515 KFTL H + ++ F P L ++S D +K+W + D + T H Sbjct: 38 KFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWG-----------AYDGKFEKTISGH 86 Query: 516 KGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGL 575 K + V SS+ S D ++ W+ ++ L GH++ V+ Sbjct: 87 KLGISDVAWSSDSNLLVSASDDKTLKIWDVSSGKC-----------LKTLKGHSNYVFCC 135 Query: 576 AYSAAHQRLLSCSADGTLRLWN--TTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVAS 633 ++ ++S S D ++R+W+ T + L +D P S + D S +V+S Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSD------PVSAVHFNRDGSLIVSS 189 Query: 634 FSKGYTSIFNMETQQRILTLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDN 693 G I++ + Q + TL +D + + ++ V P + A D +K +D Sbjct: 190 SYDGLCRIWDTASGQCLKTL---ID---DDNPPVSFVKFSPNGKYILAATLDNTLKLWDY 243 Query: 694 NTGKLIHSMVAHLEAVTSLAVD---PNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKK 750 + GK + + H + + G +++SGS D + +WNL++K +Q+ H Sbjct: 244 SKGKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGH--- 300 Query: 751 FEESIHDVAFHPSKCYIASAGAD 773 + + A HP++ IASA + Sbjct: 301 -TDVVISTACHPTENIIASAALE 322 Score = 62.8 bits (151), Expect = 1e-09 Identities = 63/263 (23%), Positives = 118/263 (44%), Gaps = 31/263 (11%) Query: 495 TAPAKKSTSLDVEPIY----TFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNI 550 ++ A +S V+P Y T H V V S NGE S D LI+ W Sbjct: 20 SSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA----- 74 Query: 551 DPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFND 610 YD + G LG +D W S+ L+S S D TL++W+ + L Sbjct: 75 --YDGKFEKTISGHKLGISDVAW----SSDSNLLVSASDDKTLKIWDVSS-GKCLKTLK- 126 Query: 611 TKELGIPASVDLVSSDP-SHMVASFSKGYT-SIFNMETQQRILTLESNVDTTANSSCQIN 668 G V + +P S+++ S S + I++++T + + TL ++ D S+ N Sbjct: 127 ----GHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPV--SAVHFN 180 Query: 669 RVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEA-VTSLAVDPNGLYLMSGSHD 727 R S + +++ D + +D +G+ + +++ V+ + PNG Y+++ + D Sbjct: 181 RDGS-----LIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLD 235 Query: 728 CSIRLWNLESKTCIQEFTAHRKK 750 +++LW+ C++ +T H+ + Sbjct: 236 NTLKLWDYSKGKCLKTYTGHKNE 258 Score = 62.4 bits (150), Expect = 2e-09 Identities = 56/222 (25%), Positives = 105/222 (47%), Gaps = 20/222 (9%) Query: 561 LRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASV 620 L+ L GHT AV + +S + L S SAD +++W + ++ +LGI Sbjct: 37 LKFTLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGH--KLGIS--- 91 Query: 621 DLVSSDPSHMVASFSKGYT-SIFNMETQQRILTLE--SNVDTTANSSCQINRVISHPTLP 677 D+ S S+++ S S T I+++ + + + TL+ SN N + Q N ++S Sbjct: 92 DVAWSSDSNLLVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVS----- 146 Query: 678 ISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLES 737 D ++ +D TGK + ++ AH + V+++ + +G ++S S+D R+W+ S Sbjct: 147 ----GSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTAS 202 Query: 738 KTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 C++ + V F P+ YI +A D K++ Sbjct: 203 GQCLKTLI---DDDNPPVSFVKFSPNGKYILAATLDNTLKLW 241 >gi|21536371 telomerase-associated protein 1 [Homo sapiens] Length = 2627 Score = 70.5 bits (171), Expect = 6e-12 Identities = 67/277 (24%), Positives = 120/277 (43%), Gaps = 22/277 (7%) Query: 475 EPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYT-FRAHKGPVLCVVMSSNGEQCYS 533 + +L +ASED T+++W Q K+ P T R H+GPV C S++G + Sbjct: 2022 QELLASASEDFTVQLWPRQLLTRPHKAEDF---PCGTELRGHEGPVSCCSFSTDGGSLAT 2078 Query: 534 GGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTL 593 GG D + W+ P P ++ H D V G A++ L+SCS+DG++ Sbjct: 2079 GGRDRSLLCWDVRTPK-------TPVLIHSFPACHRDWVTGCAWT-KDNLLISCSSDGSV 2130 Query: 594 RLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTL 653 LW+ E L F LG ++V V++ H+V+ G +++ + + Sbjct: 2131 GLWD-PESGQRLGQF-----LGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQGVELTSIP 2184 Query: 654 ESNVDTTANSSCQINRVISHP-TLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSL 712 + + ++ R P + + +T D + + H+++ H V + Sbjct: 2185 AHSGPISHCAAAMEPRAAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVRAA 2244 Query: 713 AVDPNGLYLMSGSHDCSIRLWNLESK---TCIQEFTA 746 AV +++ S D S+RLW + + TCI +A Sbjct: 2245 AVSETSGLMLTASEDGSVRLWQVPKEADDTCIPRSSA 2281 Score = 36.6 bits (83), Expect = 0.092 Identities = 35/149 (23%), Positives = 61/149 (40%), Gaps = 22/149 (14%) Query: 353 KLQDMLANLRDVDELPSLQPSVGSPSRPSSSRLPEHEINRADEVEALTFPPSSGKSFIMG 412 +L L + V + +++ V S SR + ++ +H+ VE + P SG I Sbjct: 2140 RLGQFLGHQSAVSAVAAVEEHVVSVSRDGTLKVWDHQ-----GVELTSIPAHSGP--ISH 2192 Query: 413 ADEALESELGLGELAGLTVANEADSLTYDIANNKDALRKTWNPKF-----TLRSHFDGIR 467 A+E A + S + D + W+P TL H +R Sbjct: 2193 CAAAMEPR----------AAGQPGSELLVVTVGLDGATRLWHPLLVCQTHTLLGHSGPVR 2242 Query: 468 ALAFHPIEPVLITASEDHTLKMWNLQKTA 496 A A +++TASED ++++W + K A Sbjct: 2243 AAAVSETSGLMLTASEDGSVRLWQVPKEA 2271 Score = 35.0 bits (79), Expect = 0.27 Identities = 71/323 (21%), Positives = 108/323 (33%), Gaps = 91/323 (28%) Query: 461 SHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYT--------- 511 +H + A F L+TA ED +++W+ P SL + P + Sbjct: 1882 AHHGFVAAALFLHAGCQLLTAGEDGKVQVWSGSLGRPRGHLGSLSLSPALSVALSPDGDR 1941 Query: 512 ----FRAHKGPVLCVVMSSNGEQ------------------CYSGGTDGLIQGWNTTNPN 549 +RA + + S G Q SG DG +QGW + Sbjct: 1942 VAVGYRADGIRIYKISSGSQGAQGQALDVAVSALAWLSPKVLVSGAEDGSLQGWALKECS 2001 Query: 550 IDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWNTTEVAPALSVFN 609 + + S + P+LG + + + L S S D T++LW P + Sbjct: 2002 LQ--SLWLLSRFQKPVLG---------LATSQELLASASEDFTVQLW------PRQLLTR 2044 Query: 610 DTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNVDTTANSSCQINR 669 K P +L + SFS S+ Sbjct: 2045 PHKAEDFPCGTELRGHEGPVSCCSFSTDGGSL---------------------------- 2076 Query: 670 VISHPTLPISITAHEDRHIKFYDNNTGK---LIHSMVA-HLEAVTSLAVDPNGLYLMSGS 725 T DR + +D T K LIHS A H + VT A + L L+S S Sbjct: 2077 ----------ATGGRDRSLLCWDVRTPKTPVLIHSFPACHRDWVTGCAWTKDNL-LISCS 2125 Query: 726 HDCSIRLWNLESKTCIQEFTAHR 748 D S+ LW+ ES + +F H+ Sbjct: 2126 SDGSVGLWDPESGQRLGQFLGHQ 2148 >gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] Length = 589 Score = 70.5 bits (171), Expect = 6e-12 Identities = 75/308 (24%), Positives = 115/308 (37%), Gaps = 49/308 (15%) Query: 473 PIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCY 532 P +L ++ +K+W+L+ + +DV I+ + C ++ ++ Sbjct: 278 PDSKLLAAGFDNSCIKLWSLRSKKLKSEPHQVDVSRIH--------LACDILEEEDDEDD 329 Query: 533 SGGTDGLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGT 592 + GT+ I L GH V+ + A LLSCS D + Sbjct: 330 NAGTEMKI------------------------LRGHCGPVYSTRFLADSSGLLSCSEDMS 365 Query: 593 LRLWNTTEVAPALSVFNDTKELGIPASV-DLVSSDPSHMVASFSKGYTSIFNMETQQRIL 651 +R W+ S N G V DL S S AS S T+ + + R Sbjct: 366 IRYWDLG------SFTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTA--RLWSFDRTY 417 Query: 652 TLESNVDTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTS 711 L A+ C V HP T D+ ++ + G + H V S Sbjct: 418 PLRIYAGHLADVDC----VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLS 473 Query: 712 LAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAG 771 LA PNG YL S D ++LW+L S T +E H ++I + F P IASA Sbjct: 474 LAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGH----TDNITSLTFSPDSGLIASAS 529 Query: 772 ADALAKVF 779 D +V+ Sbjct: 530 MDNSVRVW 537 Score = 64.3 bits (155), Expect = 4e-10 Identities = 46/173 (26%), Positives = 71/173 (41%), Gaps = 30/173 (17%) Query: 440 YDIANNKDALRKTWN-----PKFTLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQK 494 Y + + D + W+ P H + + FHP L T S D T+++W+ Q+ Sbjct: 398 YFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKTVRLWSAQQ 457 Query: 495 TAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTDGLIQGWNTTNPNIDPYD 554 + F H+GPVL + S NG+ S G D ++ W+ + Sbjct: 458 G-----------NSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLAS------- 499 Query: 555 SYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLW---NTTEVAPA 604 L L GHTD + L +S + S S D ++R+W NT APA Sbjct: 500 ----GTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPA 548 Score = 37.7 bits (86), Expect = 0.041 Identities = 20/56 (35%), Positives = 36/56 (64%), Gaps = 4/56 (7%) Query: 459 LRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKT---APAKKSTSLDVEPIYT 511 LR H D I +L F P ++ +AS D+++++W+++ T APA S+S ++ +YT Sbjct: 506 LRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNTYCSAPADGSSS-ELVGVYT 560 >gi|62234461 Notchless gene homolog isoform a [Homo sapiens] Length = 485 Score = 70.1 bits (170), Expect = 7e-12 Identities = 87/393 (22%), Positives = 146/393 (37%), Gaps = 89/393 (22%) Query: 458 TLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKG 517 +L H + + ++AF P L + S D T++ W+L P +T + H+ Sbjct: 109 SLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPH-----------FTCKGHRH 157 Query: 518 PVLCVVMSSNGEQCYSGGTDGLIQGWNTT--------------------------NPNID 551 VL + S +G + SG +G I W+ + NP Sbjct: 158 WVLSISWSPDGRKLASGCKNGQILLWDPSTGKQVGRTLAGHSKWITGLSWEPLHANPECR 217 Query: 552 --PYDSYDPSV---------LRGPLLGHTDAV----WG---LAYSA----------AHQR 583 S D SV L GHT +V WG L YSA AH Sbjct: 218 YVASSSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDG 277 Query: 584 LLSCSADGTLRLWNTTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFN 643 +L + G NT ++ ++ E PA + D + + S +N Sbjct: 278 VLCRTLQGHGHWVNTMALSTDYALRTGAFE---PAEASVNPQDLQGSLQELKERALSRYN 334 Query: 644 METQQRILTLESNVDT-----------------TANSSCQINRVISHPTLPISITAHEDR 686 + Q L S D IN+V+ P I +A D+ Sbjct: 335 LVRGQGPERLVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDK 394 Query: 687 HIKFYDNNTGKLIHSMVAHLEAVTSLAVDPNGLYLMSGSHDCSIRLWNLESKTCIQEFTA 746 IK +D TGK + S+ H+ AV +A + L+SGS D ++++W+++++ + Sbjct: 395 SIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG 454 Query: 747 HRKKFEESIHDVAFHPSKCYIASAGADALAKVF 779 H + ++ V + P +AS G D +++ Sbjct: 455 H----ADEVYAVDWSPDGQRVASGGKDKCLRIW 483 >gi|13376840 WD repeat domain 61 [Homo sapiens] Length = 305 Score = 69.3 bits (168), Expect = 1e-11 Identities = 69/296 (23%), Positives = 130/296 (43%), Gaps = 35/296 (11%) Query: 478 LITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKGPVLCVVMSSNGEQCYSGGTD 537 ++T S D +K+W + LD++ ++ H+ V+ V +S S D Sbjct: 35 VVTGSLDDLVKVWKW-------RDERLDLQ--WSLEGHQLGVVSVDISHTLPIAASSSLD 85 Query: 538 GLIQGWNTTNPNIDPYDSYDPSVLRGPLLGHTDAVWGLAYSAAHQRLLSCSADGTLRLWN 597 I+ W+ N S+ GP+ DA W LA+S Q L + + G + ++ Sbjct: 86 AHIRLWDLEN------GKQIKSIDAGPV----DA-WTLAFSPDSQYLATGTHVGKVNIFG 134 Query: 598 TTEVAPALSVFNDTKELGIPASVDLVSSDPSHMVASFSKGYTSIFNMETQQRILTLESNV 657 S+ DT+ I + S D ++ + G +IF++ T + + TLE + Sbjct: 135 VESGKKEYSL--DTRGKFILSIA--YSPDGKYLASGAIDGIINIFDIATGKLLHTLEGH- 189 Query: 658 DTTANSSCQINRVISHPTLPISITAHEDRHIKFYDNNTGKLIHSMVAHLEAVTSLAVDPN 717 + I + P + +TA +D +IK YD L ++ H V ++A P+ Sbjct: 190 ------AMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPD 243 Query: 718 GLYLMSGSHDCSIRLWNLESKTCIQEFTAHRKKFEESIHDVAFHPSKCYIASAGAD 773 + +S S D S+++W++ ++TC+ F H ++ + V ++ + I S G D Sbjct: 244 DTHFVSSSSDKSVKVWDVGTRTCVHTFFDH----QDQVWGVKYNGNGSKIVSVGDD 295 Score = 43.1 bits (100), Expect = 0.001 Identities = 33/141 (23%), Positives = 58/141 (41%), Gaps = 24/141 (17%) Query: 458 TLRSHFDGIRALAFHPIEPVLITASEDHTLKMWNLQKTAPAKKSTSLDVEPIYTFRAHKG 517 TL H IR+L F P +L+TAS+D +K++++Q A T H Sbjct: 185 TLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAG-----------TLSGHAS 233 Query: 518 PVLCVVMSSNGEQCYSGGTDGLIQGWNT-TNPNIDPYDSYDPSVLRGPLLGHTDAVWGLA 576 VL V + S +D ++ W+ T + + H D VWG+ Sbjct: 234 WVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTF------------FDHQDQVWGVK 281 Query: 577 YSAAHQRLLSCSADGTLRLWN 597 Y+ +++S D + +++ Sbjct: 282 YNGNGSKIVSVGDDQEIHIYD 302 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.313 0.130 0.375 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 30,314,394 Number of Sequences: 37866 Number of extensions: 1411282 Number of successful extensions: 8209 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 220 Number of HSP's successfully gapped in prelim test: 241 Number of HSP's that attempted gapping in prelim test: 5624 Number of HSP's gapped (non-prelim): 1877 length of query: 780 length of database: 18,247,518 effective HSP length: 110 effective length of query: 670 effective length of database: 14,082,258 effective search space: 9435112860 effective search space used: 9435112860 T: 11 A: 40 X1: 16 ( 7.2 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (21.9 bits) S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.