Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 50980309
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein,
homolog [Homo sapiens]
(518 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog... 1033 0.0
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 109 5e-24
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 109 5e-24
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 105 1e-22
gi|16554629 WD repeat domain 5 [Homo sapiens] 103 5e-22
gi|16554627 WD repeat domain 5 [Homo sapiens] 103 5e-22
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 99 9e-21
gi|23199987 WD repeat domain 5B [Homo sapiens] 98 2e-20
gi|26665869 WD repeat domain 51B [Homo sapiens] 96 8e-20
gi|21071067 TBP-associated factor 5 [Homo sapiens] 90 6e-18
gi|32189425 WD repeat domain 69 [Homo sapiens] 89 7e-18
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 88 2e-17
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 84 3e-16
gi|113865883 WD repeat domain 38 [Homo sapiens] 84 4e-16
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 84 4e-16
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 81 3e-15
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 81 3e-15
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 79 8e-15
gi|102470001 PQQ repeat and WD repeat domain containing [Homo sa... 79 1e-14
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 78 2e-14
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 75 1e-13
gi|157266266 WD repeat domain 86 [Homo sapiens] 74 3e-13
gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [H... 73 5e-13
gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [H... 73 5e-13
gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [H... 73 5e-13
gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [H... 73 7e-13
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 70 4e-12
gi|4503513 eukaryotic translation initiation factor 3, subunit 2... 69 8e-12
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 69 1e-11
gi|5729852 guanine nucleotide-binding protein, beta-5 subunit is... 68 2e-11
>gi|50980309 UTP15, U3 small nucleolar ribonucleoprotein, homolog
[Homo sapiens]
Length = 518
Score = 1033 bits (2671), Expect = 0.0
Identities = 518/518 (100%), Positives = 518/518 (100%)
Query: 1 MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASS 60
MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASS
Sbjct: 1 MAGYKPVAIQTYPILGEKITQDTLYWNNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASS 60
Query: 61 RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEG 120
RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEG
Sbjct: 61 RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEG 120
Query: 121 HTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLF 180
HTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLF
Sbjct: 121 HTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLF 180
Query: 181 ITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQL 240
ITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQL
Sbjct: 181 ITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQL 240
Query: 241 LVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHE 300
LVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHE
Sbjct: 241 LVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHE 300
Query: 301 DETIVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKNYMKQRDDILINRPAKKH 360
DETIVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKNYMKQRDDILINRPAKKH
Sbjct: 301 DETIVVGMTNGILSVKHRKSEAKKESLPRRRRPAYRTFIKGKNYMKQRDDILINRPAKKH 360
Query: 361 LELYDRDLKHFRISKALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISH 420
LELYDRDLKHFRISKALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISH
Sbjct: 361 LELYDRDLKHFRISKALDRVLDPTCTIKTPEITVSIIKELNRRGVLANALAGRDEKEISH 420
Query: 421 VLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQREL 480
VLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQREL
Sbjct: 421 VLNFLIRNLSQPRFAPVLINAAEIIIDIYLPVIGQSPVVDKKFLLLQGLVEKEIDYQREL 480
Query: 481 LETLGMMDMLFATMRRKEGTSVLEHTSDGFPENKKIES 518
LETLGMMDMLFATMRRKEGTSVLEHTSDGFPENKKIES
Sbjct: 481 LETLGMMDMLFATMRRKEGTSVLEHTSDGFPENKKIES 518
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 109 bits (273), Expect = 5e-24
Identities = 78/250 (31%), Positives = 123/250 (49%), Gaps = 8/250 (3%)
Query: 40 AVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGS 99
AV+ VDFS + + S + ++ Q F+ KD C F G LL +GS
Sbjct: 21 AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGS 80
Query: 100 EDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILT 159
D V+++ + + F HT V +V F +D V+ +DD TVK+W K + +
Sbjct: 81 RDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS 140
Query: 160 FKEHSDYVRCGCASKLNPD--LFITGSYDHTVKMFDARTSESVLS-VEHGQPVESVLLFP 216
+H ++VRC +K +PD L ++ S D TVK++D + E V S EHG V V P
Sbjct: 141 LSQHINWVRC---AKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP 197
Query: 217 SGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVY 275
SG + +AG VKVWD ++ +LL + H V L SG L++ S D +K+
Sbjct: 198 SGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKIL 256
Query: 276 STTSYKVVHS 285
+++++
Sbjct: 257 DLMEGRLLYT 266
Score = 80.9 bits (198), Expect = 3e-15
Identities = 63/246 (25%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 76 FSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKY 135
F +D C F + + L +GS D + ++ + ++ +F GH AV V+F+ +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 136 HVVSGADDYTVKLWDIPNSK-EILTFKEHSDYVRC--GCASKLNPDLFITGSYDHTVKMF 192
+ SG+ D TV++W +PN K E F+ H+ VR C+ + F+T S D TVK++
Sbjct: 75 LLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCS---DGQSFVTASDDKTVKVW 130
Query: 193 DARTSESVLSV-EHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKT 250
+ + S+ +H V P G L+VSA + VK+WD + + S H
Sbjct: 131 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK-SSRECVHSYCEHGGF 189
Query: 251 VTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFD-YAASILSLALAHEDETIVVGMT 309
VT + SG + + +D VKV+ +++++ + ++A++ L+ ++ +
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 310 NGILSV 315
+ L +
Sbjct: 250 DSTLKI 255
Score = 75.1 bits (183), Expect = 1e-13
Identities = 62/203 (30%), Positives = 92/203 (45%), Gaps = 14/203 (6%)
Query: 116 RQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKL 175
R F+GH AV VDF+ + + SG+ D + +W + F H D V C S
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP- 71
Query: 176 NPDLFITGSYDHTVKMFDART-SESVLSVEHGQPVESVLLFPSGGLLVSAG-GRYVKVWD 233
+ L +GS D TV+++ ES + H V SV G V+A + VKVW
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 234 MLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF------- 286
+ + L SL H V C S G+ ++S S D+ VK++ +S + VHS+
Sbjct: 132 THR-QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV 190
Query: 287 ---DYAASILSLALAHEDETIVV 306
D+ S +A A D T+ V
Sbjct: 191 TYVDFHPSGTCIAAAGMDNTVKV 213
Score = 69.7 bits (169), Expect = 6e-12
Identities = 51/181 (28%), Positives = 87/181 (48%), Gaps = 5/181 (2%)
Query: 56 VTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRA 113
VTAS + ++ + Q+ + + S+ + CA F DGRL+V+ S+D V+L+D S R
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCAS 173
+ + H V VDF + + D TVK+WD+ + + ++ HS V G +
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN-GLSF 237
Query: 174 KLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGG--RYVKV 231
+ + IT S D T+K+ D + ++ Q + + F G ++GG V V
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Query: 232 W 232
W
Sbjct: 298 W 298
Score = 38.1 bits (87), Expect = 0.020
Identities = 24/111 (21%), Positives = 42/111 (37%)
Query: 39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAG 98
G V+ VDF P A + + ++ + ++ + +F G L+
Sbjct: 188 GFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITA 247
Query: 99 SEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLW 149
S D +++ D+ L GH TV F+ + SG D V +W
Sbjct: 248 SSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 109 bits (273), Expect = 5e-24
Identities = 78/250 (31%), Positives = 123/250 (49%), Gaps = 8/250 (3%)
Query: 40 AVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGS 99
AV+ VDFS + + S + ++ Q F+ KD C F G LL +GS
Sbjct: 21 AVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGS 80
Query: 100 EDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILT 159
D V+++ + + F HT V +V F +D V+ +DD TVK+W K + +
Sbjct: 81 RDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWATHRQKFLFS 140
Query: 160 FKEHSDYVRCGCASKLNPD--LFITGSYDHTVKMFDARTSESVLS-VEHGQPVESVLLFP 216
+H ++VRC +K +PD L ++ S D TVK++D + E V S EHG V V P
Sbjct: 141 LSQHINWVRC---AKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFVTYVDFHP 197
Query: 217 SGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVY 275
SG + +AG VKVWD ++ +LL + H V L SG L++ S D +K+
Sbjct: 198 SGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKIL 256
Query: 276 STTSYKVVHS 285
+++++
Sbjct: 257 DLMEGRLLYT 266
Score = 80.9 bits (198), Expect = 3e-15
Identities = 63/246 (25%), Positives = 119/246 (48%), Gaps = 11/246 (4%)
Query: 76 FSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKY 135
F +D C F + + L +GS D + ++ + ++ +F GH AV V+F+ +
Sbjct: 15 FKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGH 74
Query: 136 HVVSGADDYTVKLWDIPNSK-EILTFKEHSDYVRC--GCASKLNPDLFITGSYDHTVKMF 192
+ SG+ D TV++W +PN K E F+ H+ VR C+ + F+T S D TVK++
Sbjct: 75 LLASGSRDKTVRIW-VPNVKGESTVFRAHTATVRSVHFCS---DGQSFVTASDDKTVKVW 130
Query: 193 DARTSESVLSV-EHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKT 250
+ + S+ +H V P G L+VSA + VK+WD + + S H
Sbjct: 131 ATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDK-SSRECVHSYCEHGGF 189
Query: 251 VTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFD-YAASILSLALAHEDETIVVGMT 309
VT + SG + + +D VKV+ +++++ + ++A++ L+ ++ +
Sbjct: 190 VTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASS 249
Query: 310 NGILSV 315
+ L +
Sbjct: 250 DSTLKI 255
Score = 75.1 bits (183), Expect = 1e-13
Identities = 62/203 (30%), Positives = 92/203 (45%), Gaps = 14/203 (6%)
Query: 116 RQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKL 175
R F+GH AV VDF+ + + SG+ D + +W + F H D V C S
Sbjct: 13 RHFKGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSP- 71
Query: 176 NPDLFITGSYDHTVKMFDART-SESVLSVEHGQPVESVLLFPSGGLLVSAG-GRYVKVWD 233
+ L +GS D TV+++ ES + H V SV G V+A + VKVW
Sbjct: 72 SGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVWA 131
Query: 234 MLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF------- 286
+ + L SL H V C S G+ ++S S D+ VK++ +S + VHS+
Sbjct: 132 THR-QKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYCEHGGFV 190
Query: 287 ---DYAASILSLALAHEDETIVV 306
D+ S +A A D T+ V
Sbjct: 191 TYVDFHPSGTCIAAAGMDNTVKV 213
Score = 69.7 bits (169), Expect = 6e-12
Identities = 51/181 (28%), Positives = 87/181 (48%), Gaps = 5/181 (2%)
Query: 56 VTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRA 113
VTAS + ++ + Q+ + + S+ + CA F DGRL+V+ S+D V+L+D S R
Sbjct: 119 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 178
Query: 114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCAS 173
+ + H V VDF + + D TVK+WD+ + + ++ HS V G +
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN-GLSF 237
Query: 174 KLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGG--RYVKV 231
+ + IT S D T+K+ D + ++ Q + + F G ++GG V V
Sbjct: 238 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 297
Query: 232 W 232
W
Sbjct: 298 W 298
Score = 38.1 bits (87), Expect = 0.020
Identities = 24/111 (21%), Positives = 42/111 (37%)
Query: 39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAG 98
G V+ VDF P A + + ++ + ++ + +F G L+
Sbjct: 188 GFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITA 247
Query: 99 SEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLW 149
S D +++ D+ L GH TV F+ + SG D V +W
Sbjct: 248 SSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVW 298
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 105 bits (261), Expect = 1e-22
Identities = 70/214 (32%), Positives = 109/214 (50%), Gaps = 8/214 (3%)
Query: 76 FSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKY 135
F+ KD C F G LL +GS D V+++ + + F HT V +V F +D
Sbjct: 19 FTGHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHFCSDGQ 78
Query: 136 HVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPD--LFITGSYDHTVKMFD 193
V+ +DD TVK+W K + + +H ++VRC +K +PD L ++ S D TVK++D
Sbjct: 79 SFVTASDDKTVKVWATHRQKFLFSLSQHINWVRC---AKFSPDGRLIVSASDDKTVKLWD 135
Query: 194 ARTSESVLS-VEHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTV 251
+ E V S EHG V V PSG + +AG VKVWD ++ +LL + H V
Sbjct: 136 KSSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWD-VRTHRLLQHYQLHSAAV 194
Query: 252 TCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHS 285
L SG L++ S D +K+ +++++
Sbjct: 195 NGLSFHPSGNYLITASSDSTLKILDLMEGRLLYT 228
Score = 69.7 bits (169), Expect = 6e-12
Identities = 51/181 (28%), Positives = 87/181 (48%), Gaps = 5/181 (2%)
Query: 56 VTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRA 113
VTAS + ++ + Q+ + + S+ + CA F DGRL+V+ S+D V+L+D S R
Sbjct: 81 VTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRE 140
Query: 114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCAS 173
+ + H V VDF + + D TVK+WD+ + + ++ HS V G +
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQLHSAAVN-GLSF 199
Query: 174 KLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGG--RYVKV 231
+ + IT S D T+K+ D + ++ Q + + F G ++GG V V
Sbjct: 200 HPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMV 259
Query: 232 W 232
W
Sbjct: 260 W 260
Score = 68.9 bits (167), Expect = 1e-11
Identities = 56/221 (25%), Positives = 108/221 (48%), Gaps = 11/221 (4%)
Query: 101 DGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSK-EILT 159
D + ++ + ++ +F GH AV V+F+ + + SG+ D TV++W +PN K E
Sbjct: 2 DSCLMVWHMKPQSRAYRFTGHKDAVTCVNFSPSGHLLASGSRDKTVRIW-VPNVKGESTV 60
Query: 160 FKEHSDYVRC--GCASKLNPDLFITGSYDHTVKMFDARTSESVLSV-EHGQPVESVLLFP 216
F+ H+ VR C+ + F+T S D TVK++ + + S+ +H V P
Sbjct: 61 FRAHTATVRSVHFCS---DGQSFVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSP 117
Query: 217 SGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVY 275
G L+VSA + VK+WD + + S H VT + SG + + +D VKV+
Sbjct: 118 DGRLIVSASDDKTVKLWDK-SSRECVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW 176
Query: 276 STTSYKVVHSFD-YAASILSLALAHEDETIVVGMTNGILSV 315
+++++ + ++A++ L+ ++ ++ L +
Sbjct: 177 DVRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKI 217
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 103 bits (256), Expect = 5e-22
Identities = 75/274 (27%), Positives = 132/274 (48%), Gaps = 12/274 (4%)
Query: 40 AVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGS 99
AVS V FSP + + +A I I+G Y + KT S K + D LLV+ S
Sbjct: 47 AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS 106
Query: 100 EDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILT 159
+D ++++D+S L+ +GH+ V +F +VSG+ D +V++WD+ K + T
Sbjct: 107 DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKT 166
Query: 160 FKEHSDYVRCGCASKLNPD--LFITGSYDHTVKMFDARTSESVLSV--EHGQPVESVLLF 215
HSD V A N D L ++ SYD +++D + + + ++ + PV V
Sbjct: 167 LPAHSDPV---SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223
Query: 216 PSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSS---GQRLLSGSLDRK 271
P+G +++A +K+WD K G+ L + H C+ + S G+ ++SGS D
Sbjct: 224 PNGKYILAATLDNTLKLWDYSK-GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
Query: 272 VKVYSTTSYKVVHSFDYAASILSLALAHEDETIV 305
V +++ + ++V ++ H E I+
Sbjct: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/211 (25%), Positives = 99/211 (46%), Gaps = 45/211 (21%)
Query: 120 GHTKAVHTVDF------------------------------------------TADKYHV 137
GHTKAV +V F ++D +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 138 VSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTS 197
VS +DD T+K+WD+ + K + T K HS+YV C C +L ++GS+D +V+++D +T
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC-CNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 198 ESVLSV-EHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLC 255
+ + ++ H PV +V G L+VS+ ++WD G L + + + V+ +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 256 LSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF 286
S +G+ +L+ +LD +K++ + K + ++
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 103 bits (256), Expect = 5e-22
Identities = 75/274 (27%), Positives = 132/274 (48%), Gaps = 12/274 (4%)
Query: 40 AVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGS 99
AVS V FSP + + +A I I+G Y + KT S K + D LLV+ S
Sbjct: 47 AVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLLVSAS 106
Query: 100 EDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILT 159
+D ++++D+S L+ +GH+ V +F +VSG+ D +V++WD+ K + T
Sbjct: 107 DDKTLKIWDVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKT 166
Query: 160 FKEHSDYVRCGCASKLNPD--LFITGSYDHTVKMFDARTSESVLSV--EHGQPVESVLLF 215
HSD V A N D L ++ SYD +++D + + + ++ + PV V
Sbjct: 167 LPAHSDPV---SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKFS 223
Query: 216 PSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSS---GQRLLSGSLDRK 271
P+G +++A +K+WD K G+ L + H C+ + S G+ ++SGS D
Sbjct: 224 PNGKYILAATLDNTLKLWDYSK-GKCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNL 282
Query: 272 VKVYSTTSYKVVHSFDYAASILSLALAHEDETIV 305
V +++ + ++V ++ H E I+
Sbjct: 283 VYIWNLQTKEIVQKLQGHTDVVISTACHPTENII 316
Score = 78.2 bits (191), Expect = 2e-14
Identities = 53/211 (25%), Positives = 99/211 (46%), Gaps = 45/211 (21%)
Query: 120 GHTKAVHTVDF------------------------------------------TADKYHV 137
GHTKAV +V F ++D +
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSNLL 102
Query: 138 VSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTS 197
VS +DD T+K+WD+ + K + T K HS+YV C C +L ++GS+D +V+++D +T
Sbjct: 103 VSASDDKTLKIWDVSSGKCLKTLKGHSNYVFC-CNFNPQSNLIVSGSFDESVRIWDVKTG 161
Query: 198 ESVLSV-EHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLC 255
+ + ++ H PV +V G L+VS+ ++WD G L + + + V+ +
Sbjct: 162 KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVK 221
Query: 256 LSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF 286
S +G+ +L+ +LD +K++ + K + ++
Sbjct: 222 FSPNGKYILAATLDNTLKLWDYSKGKCLKTY 252
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 99.0 bits (245), Expect = 9e-21
Identities = 61/213 (28%), Positives = 104/213 (48%), Gaps = 3/213 (1%)
Query: 70 QEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAP-LRQFEGHTKAVHTV 128
Q PI S + YC F +G L + D + L+++ G +GH+ AV +
Sbjct: 56 QAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNVYGDCDNYATLKGHSGAVMEL 115
Query: 129 DFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHT 188
+ D + S + D TV +WD + + K H+ +V ++ P L TGS D T
Sbjct: 116 HYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVCTGSDDGT 175
Query: 189 VKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNH 247
VK++D R ++ + ++ V +V + ++S G +KVWD L+ +L +++ H
Sbjct: 176 VKLWDIRKKAAIQTFQNTYQVLAVTFNDTSDQIISGGIDNDIKVWD-LRQNKLTYTMRGH 234
Query: 248 HKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSY 280
+VT L LSS G LLS ++D V+V+ +
Sbjct: 235 ADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPF 267
Score = 35.8 bits (81), Expect = 0.097
Identities = 19/73 (26%), Positives = 37/73 (50%)
Query: 79 FKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVV 138
F+ ++ DG + AGS D V ++D + R L + GH +++ V F D+ ++
Sbjct: 284 FEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIII 343
Query: 139 SGADDYTVKLWDI 151
S + D + + +I
Sbjct: 344 SASSDKRLYMGEI 356
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 97.8 bits (242), Expect = 2e-20
Identities = 70/272 (25%), Positives = 129/272 (47%), Gaps = 8/272 (2%)
Query: 40 AVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGS 99
AVS V FSP + + +A I I+G Y + KT + D LV+ S
Sbjct: 43 AVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRLVSAS 102
Query: 100 EDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILT 159
+D ++L+D+ L+ +GH+ V +F ++SG+ D TVK+W++ K + T
Sbjct: 103 DDKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKT 162
Query: 160 FKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSV--EHGQPVESVLLFPS 217
HSD V + L ++GSYD +++DA + + + ++ + PV V P+
Sbjct: 163 LSAHSDPV-SAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFSPN 221
Query: 218 GGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSS---GQRLLSGSLDRKVK 273
G +++A +K+WD + G+ L + H C+ + S G+ ++SGS D V
Sbjct: 222 GKYILTATLDNTLKLWDYSR-GRCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVY 280
Query: 274 VYSTTSYKVVHSFDYAASILSLALAHEDETIV 305
+++ + ++V ++ A H E ++
Sbjct: 281 IWNLQTKEIVQKLQGHTDVVISAACHPTENLI 312
Score = 78.6 bits (192), Expect = 1e-14
Identities = 57/202 (28%), Positives = 96/202 (47%), Gaps = 49/202 (24%)
Query: 120 GHTKAVHTVDF------------------------------------------TADKYHV 137
GHT+AV +V F ++D +
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWSSDSSRL 98
Query: 138 VSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTS 197
VS +DD T+KLWD+ + K + T K HS+YV C C +L I+GS+D TVK+++ +T
Sbjct: 99 VSASDDKTLKLWDVRSGKCLKTLKGHSNYVFC-CNFNPPSNLIISGSFDETVKIWEVKTG 157
Query: 198 ESVLSVE-HGQPVESVLLFPSGGLLVSAGGRY---VKVWDMLKGGQLLVSLKNHHKTVTC 253
+ + ++ H PV +V SG L+VS G Y ++WD G L + + + V+
Sbjct: 158 KCLKTLSAHSDPVSAVHFNCSGSLIVS--GSYDGLCRIWDAASGQCLKTLVDDDNPPVSF 215
Query: 254 LCLSSSGQRLLSGSLDRKVKVY 275
+ S +G+ +L+ +LD +K++
Sbjct: 216 VKFSPNGKYILTATLDNTLKLW 237
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 95.9 bits (237), Expect = 8e-20
Identities = 64/250 (25%), Positives = 120/250 (48%), Gaps = 8/250 (3%)
Query: 40 AVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGS 99
A++ +D SP + + + ++ + KD F G LL + S
Sbjct: 20 AITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSPHGNLLASAS 79
Query: 100 EDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILT 159
D V+L+ R +F+ HT V +VDF+AD + + ++D ++K+W + + + +
Sbjct: 80 RDRTVRLWIPDKRGKFSEFKAHTAPVRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYS 139
Query: 160 FKEHSDYVRCGCASKLNPD--LFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLF-P 216
H+ +VRC +K +PD L ++ S D T+K++D + V + + + F P
Sbjct: 140 LYRHTHWVRC---AKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGFANFVDFNP 196
Query: 217 SGGLLVSAGG-RYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVY 275
SG + SAG + VKVWD ++ +LL + H V C+ SG L++ S D +K+
Sbjct: 197 SGTCIASAGSDQTVKVWD-VRVNKLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKIL 255
Query: 276 STTSYKVVHS 285
+++++
Sbjct: 256 DLLEGRLIYT 265
Score = 82.0 bits (201), Expect = 1e-15
Identities = 55/192 (28%), Positives = 91/192 (47%), Gaps = 3/192 (1%)
Query: 41 VSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSE 100
V VDFS + + I ++ Y Q + + R CA F DGRL+V+ SE
Sbjct: 105 VRSVDFSADGQFLATASEDKSIKVWSMYRQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSE 164
Query: 101 DGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTF 160
D ++++D + + + F + VDF + S D TVK+WD+ +K + +
Sbjct: 165 DKTIKIWDTTNKQCVNNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHY 224
Query: 161 KEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLLFPSGG 219
+ HS V C + + + IT S D T+K+ D + +++ H PV +V F GG
Sbjct: 225 QVHSGGVNC-ISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTV-SFSKGG 282
Query: 220 LLVSAGGRYVKV 231
L ++GG +V
Sbjct: 283 ELFASGGADTQV 294
Score = 66.6 bits (161), Expect = 5e-11
Identities = 56/204 (27%), Positives = 94/204 (46%), Gaps = 16/204 (7%)
Query: 116 RQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKL 175
R F+GH A+ ++D + + + + + D + LW+ + H D V S
Sbjct: 12 RYFKGHKAAITSLDLSPNGKQLATASWDTFLMLWNFKPHARAYRYVGHKDVVTSVQFSP- 70
Query: 176 NPDLFITGSYDHTVKMF--DARTSESVLSVEHGQPVESVLLFPSGGLLVSAG-GRYVKVW 232
+ +L + S D TV+++ D R S H PV SV G L +A + +KVW
Sbjct: 71 HGNLLASASRDRTVRLWIPDKRGKFSEFKA-HTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 233 DMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF------ 286
M + + L SL H V C S G+ ++S S D+ +K++ TT+ + V++F
Sbjct: 130 SMYRQ-RFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF 188
Query: 287 ----DYAASILSLALAHEDETIVV 306
D+ S +A A D+T+ V
Sbjct: 189 ANFVDFNPSGTCIASAGSDQTVKV 212
Score = 45.1 bits (105), Expect = 2e-04
Identities = 29/123 (23%), Positives = 49/123 (39%), Gaps = 5/123 (4%)
Query: 27 NNYKTPVQIKEFGAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCA 86
NN+ V F VDF+P + + + ++ + ++ + C
Sbjct: 180 NNFSDSVGFANF-----VDFNPSGTCIASAGSDQTVKVWDVRVNKLLQHYQVHSGGVNCI 234
Query: 87 TFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTV 146
+F G L+ S DG +++ D+ + +GHT V TV F+ SG D V
Sbjct: 235 SFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGGELFASGGADTQV 294
Query: 147 KLW 149
LW
Sbjct: 295 LLW 297
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 89.7 bits (221), Expect = 6e-18
Identities = 65/228 (28%), Positives = 110/228 (48%), Gaps = 7/228 (3%)
Query: 84 YCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADD 143
Y A+F D L++ SEDG V+L+ + L ++GH V F+ Y+ VSG D
Sbjct: 547 YGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHD 606
Query: 144 YTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESV-LS 202
+LW + + + F H V C N + TGS D TV+++D V +
Sbjct: 607 RVARLWATDHYQPLRIFAGHLADVNC-TRFHPNSNYVATGSADRTVRLWDVLNGNCVRIF 665
Query: 203 VEHGQPVESVLLFPSGGLLVSAG--GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSG 260
H P+ S+ P+G L + GR V +WD + G ++ LK H TV L S G
Sbjct: 666 TGHKGPIHSLTFSPNGRFLATGATDGR-VLLWD-IGHGLMVGELKGHTDTVCSLRFSRDG 723
Query: 261 QRLLSGSLDRKVKVY-STTSYKVVHSFDYAASILSLALAHEDETIVVG 307
+ L SGS+D V+++ + +++ + + D+ + + L + +++G
Sbjct: 724 EILASGSMDNTVRLWDAIKAFEDLETDDFTTATGHINLPENSQELLLG 771
Score = 68.2 bits (165), Expect = 2e-11
Identities = 39/147 (26%), Positives = 70/147 (47%), Gaps = 4/147 (2%)
Query: 51 PYNYAVTASSR---IHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLF 107
PY Y + ++ +P++ F+ C F + + GS D V+L+
Sbjct: 595 PYGYYFVSGGHDRVARLWATDHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLW 654
Query: 108 DISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYV 167
D+ +R F GH +H++ F+ + + +GA D V LWDI + + K H+D V
Sbjct: 655 DVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTV 714
Query: 168 RCGCASKLNPDLFITGSYDHTVKMFDA 194
C + ++ +GS D+TV+++DA
Sbjct: 715 -CSLRFSRDGEILASGSMDNTVRLWDA 740
Score = 59.3 bits (142), Expect = 8e-09
Identities = 33/103 (32%), Positives = 54/103 (52%), Gaps = 2/103 (1%)
Query: 50 PPYNYAVTASS--RIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLF 107
P NY T S+ + ++ + ++ F+ K + TF +GR L G+ DG V L+
Sbjct: 637 PNSNYVATGSADRTVRLWDVLNGNCVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
Query: 108 DISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
DI + + +GHT V ++ F+ D + SG+ D TV+LWD
Sbjct: 697 DIGHGLMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 44.7 bits (104), Expect = 2e-04
Identities = 47/174 (27%), Positives = 73/174 (41%), Gaps = 19/174 (10%)
Query: 115 LRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASK 174
L ++G T VD T D + G D TV++W + K++ + K+ SD
Sbjct: 467 LNAYQGLT----AVDVTDDSSLIAGGFADSTVRVWSV-TPKKLRSVKQASDL-------- 513
Query: 175 LNPDLFITGSYDHTVKMFDART-SESVLSVEHGQPVESVLLFPSGG-LLVSAGGRYVKVW 232
L S D ++ D +T SE + H PV P LL S+ V++W
Sbjct: 514 ---SLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDRNYLLSSSEDGTVRLW 570
Query: 233 DMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF 286
L+ LV K H+ V S G +SG DR ++++T Y+ + F
Sbjct: 571 S-LQTFTCLVGYKGHNYPVWDTQFSPYGYYFVSGGHDRVARLWATDHYQPLRIF 623
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 89.4 bits (220), Expect = 7e-18
Identities = 64/247 (25%), Positives = 106/247 (42%), Gaps = 15/247 (6%)
Query: 50 PPYNYAVTASSRIHIYGRY----------SQEPIKTFSRFKDTAYCATFRQD-GRLLVAG 98
P N A+ S I G Y S E + T ++ Y F G + G
Sbjct: 94 PLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATG 153
Query: 99 SEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIL 158
S D +L+ + F GHT + + F V +G+ D T KLWDI N +E+
Sbjct: 154 SFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEEVY 213
Query: 159 TFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESV-LSVEHGQPVESVLL-FP 216
T + HS + + + D ITGS+DHTV ++DA T V + + H + S +
Sbjct: 214 TLRGHSAEI-ISLSFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWD 272
Query: 217 SGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 276
+L + + K+WD G+ + +L H + C +G+ + + S D +++S
Sbjct: 273 CSLILTGSMDKTCKLWD-ATNGKCVATLTGHDDEILDSCFDYTGKLIATASADGTARIFS 331
Query: 277 TTSYKVV 283
+ K +
Sbjct: 332 AATRKCI 338
Score = 67.8 bits (164), Expect = 2e-11
Identities = 50/174 (28%), Positives = 84/174 (48%), Gaps = 6/174 (3%)
Query: 138 VSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTS 197
++G+ D T KLWD + +E+ T + H + V + D TGS+D T K++ T
Sbjct: 108 ITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETG 167
Query: 198 ESVLSVEHGQPVESVLL-FPSGGLLVSAGGR--YVKVWDMLKGGQLLVSLKNHHKTVTCL 254
+ + G E V L F LV+ G K+WD ++ G+ + +L+ H + L
Sbjct: 168 KCYHTFR-GHTAEIVCLSFNPQSTLVATGSMDTTAKLWD-IQNGEEVYTLRGHSAEIISL 225
Query: 255 CLSSSGQRLLSGSLDRKVKVY-STTSYKVVHSFDYAASILSLALAHEDETIVVG 307
++SG R+++GS D V V+ + T KV + A I S + + I+ G
Sbjct: 226 SFNTSGDRIITGSFDHTVVVWDADTGRKVNILIGHCAEISSASFNWDCSLILTG 279
Score = 62.0 bits (149), Expect = 1e-09
Identities = 30/120 (25%), Positives = 59/120 (49%), Gaps = 1/120 (0%)
Query: 73 IKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTA 132
+ T + D + F G+L+ S DG ++F + R + + EGH + + F
Sbjct: 296 VATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRKCIAKLEGHEGEISKISFNP 355
Query: 133 DKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMF 192
H+++G+ D T ++WD + + + H+D + CA ++ ITGS D+T +++
Sbjct: 356 QGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEI-FSCAFNYKGNIVITGSKDNTCRIW 414
Score = 31.6 bits (70), Expect = 1.8
Identities = 13/69 (18%), Positives = 32/69 (46%)
Query: 39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAG 98
G +SK+ F+PQ + ++ I+ + + ++ D + F G +++ G
Sbjct: 346 GEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNIVITG 405
Query: 99 SEDGGVQLF 107
S+D +++
Sbjct: 406 SKDNTCRIW 414
Score = 29.3 bits (64), Expect = 9.1
Identities = 14/44 (31%), Positives = 26/44 (59%)
Query: 244 LKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFD 287
LK H +T + L+ SG ++GS DR K++ T S + +++ +
Sbjct: 88 LKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLE 131
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 87.8 bits (216), Expect = 2e-17
Identities = 62/287 (21%), Positives = 130/287 (45%), Gaps = 7/287 (2%)
Query: 41 VSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSE 100
V VD P P+ A + + ++ +Q +KTF A F +V G++
Sbjct: 18 VKSVDLHPTEPWMLASLYNGSVCVWNHETQTLVKTFEVCDLPVRAAKFVARKNWVVTGAD 77
Query: 101 DGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEI-LT 159
D +++F+ + + FE H+ + + + +++ +DD +KLWD
Sbjct: 78 DMQIRVFNYNTLERVHMFEAHSDYIRCIAVHPTQPFILTSSDDMLIKLWDWDKKWSCSQV 137
Query: 160 FKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGG 219
F+ H+ YV + + + F + S D T+K++ +S ++E + + + + SGG
Sbjct: 138 FEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGG 197
Query: 220 ----LLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVY 275
L+ A R VK+WD + + +L+ H + V+C +++GS D V+++
Sbjct: 198 DKPYLISGADDRLVKIWD-YQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTVRIW 256
Query: 276 STTSYKVVHSFDYAAS-ILSLALAHEDETIVVGMTNGILSVKHRKSE 321
+++Y++ + +Y + +A + +G G + VK + E
Sbjct: 257 HSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSIIVKLGREE 303
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 84.0 bits (206), Expect = 3e-16
Identities = 61/196 (31%), Positives = 90/196 (45%), Gaps = 7/196 (3%)
Query: 85 CATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDY 144
C F D ++ V S D L+DI F GHT V ++ D VSGA D
Sbjct: 148 CCRFLDDNQI-VTSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDA 206
Query: 145 TVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE 204
+ KLWD+ TF H + C N + F TGS D T ++FD R + +++
Sbjct: 207 SAKLWDVREGMCRQTFTGHESDINAICFFP-NGNAFATGSDDATCRLFDLRADQELMTYS 265
Query: 205 HGQ---PVESVLLFPSGGLLVSAGGRY-VKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSG 260
H + SV SG LL++ + VWD LK + V L H V+CL ++ G
Sbjct: 266 HDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGV-LAGHDNRVSCLGVTDDG 324
Query: 261 QRLLSGSLDRKVKVYS 276
+ +GS D +K+++
Sbjct: 325 MAVATGSWDSFLKIWN 340
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 83.6 bits (205), Expect = 4e-16
Identities = 64/236 (27%), Positives = 112/236 (47%), Gaps = 11/236 (4%)
Query: 73 IKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTA 132
+K F + + F DG++L+ GSEDG V ++ L + GHT V F+
Sbjct: 14 VKFFGQHGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSP 73
Query: 133 DKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPD--LFITGSYDHTVK 190
D + S + D TV+LWD+ +K + K H V +PD +G +D V
Sbjct: 74 DGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVE---TVSFSPDSRQLASGGWDKRVM 130
Query: 191 MFDARTSESV-LSVEHGQPVESVLLFPSGGLLVSAG-GRYVKVWD--MLKGGQLLVSLKN 246
++D ++ + + L V H ++S P+ L + V +WD M+ +L+
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEG 190
Query: 247 HHKTVTCLCLSSSGQRLLSGSLDRKVKVYS-TTSYKVVHSFDYAASILSLALAHED 301
H ++CLC S+SG L SGS D+ + ++ TTS ++ + + S+A + ++
Sbjct: 191 HSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDE 245
Score = 81.3 bits (199), Expect = 2e-15
Identities = 63/225 (28%), Positives = 100/225 (44%), Gaps = 10/225 (4%)
Query: 88 FRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVK 147
F DG L + S D V+L+D++ LR +GH ++V TV F+ D + SG D V
Sbjct: 71 FSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVM 130
Query: 148 LWDIPNSKEILTFKEHSDYVRCGCASKLNP--DLFITGSYDHTVKMFDARTSESVLS--- 202
LWD+ + + + H D ++ +S +P + TGS+D TV ++D R +S
Sbjct: 131 LWDVQSGQMLRLLVGHRDSIQ---SSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQA 187
Query: 203 VEHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQ 261
+E S L + + GLL S + + +W LL+ LK H V + S
Sbjct: 188 LEGHSANISCLCYSASGLLASGSWDKTIHIWKPTT-SSLLIQLKGHVTWVKSIAFSPDEL 246
Query: 262 RLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVV 306
L S R VKV+ + K + + + D I+V
Sbjct: 247 WLASAGYSRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKILV 291
Score = 78.6 bits (192), Expect = 1e-14
Identities = 64/246 (26%), Positives = 110/246 (44%), Gaps = 8/246 (3%)
Query: 39 GAVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAG 98
G V FSP + + + ++ + ++ + + +F D R L +G
Sbjct: 64 GPVKFCRFSPDGHLFASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASG 123
Query: 99 SEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIL 158
D V L+D+ LR GH ++ + DF+ + +G+ D TV +WD+ +
Sbjct: 124 GWDKRVMLWDVQSGQMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAV 183
Query: 159 T---FKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLL 214
+ + HS + C C S L +GS+D T+ ++ TS ++ ++ H V+S+
Sbjct: 184 SHQALEGHSANISCLCYSA--SGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAF 241
Query: 215 FPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVK 273
P L SAG R VKVWD G+ L +LK + G+ L+SG+ D+ +
Sbjct: 242 SPDELWLASAGYSRMVKVWD-CNTGKCLETLKGVLDVAHTCAFTPDGKILVSGAADQTRR 300
Query: 274 VYSTTS 279
S TS
Sbjct: 301 QISRTS 306
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 83.6 bits (205), Expect = 4e-16
Identities = 58/194 (29%), Positives = 90/194 (46%), Gaps = 4/194 (2%)
Query: 84 YCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADD 143
Y F D L++ SED ++ +D+ ++GH V +D + + SG+ D
Sbjct: 346 YSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVWDLDISPYSLYFASGSHD 405
Query: 144 YTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESV-LS 202
T +LW + + + H V C N + TGS D TV+++ A+ SV L
Sbjct: 406 RTARLWSFDRTYPLRIYAGHLADVDC-VKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLF 464
Query: 203 VEHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQ 261
H PV S+ P+G L SAG + +K+WD L G L L+ H +T L S
Sbjct: 465 TGHRGPVLSLAFSPNGKYLASAGEDQRLKLWD-LASGTLYKELRGHTDNITSLTFSPDSG 523
Query: 262 RLLSGSLDRKVKVY 275
+ S S+D V+V+
Sbjct: 524 LIASASMDNSVRVW 537
Score = 53.5 bits (127), Expect = 4e-07
Identities = 35/156 (22%), Positives = 70/156 (44%), Gaps = 5/156 (3%)
Query: 44 VDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGG 103
+D SP Y + + ++ P++ ++ C F + L GS D
Sbjct: 390 LDISPYSLYFASGSHDRTARLWSFDRTYPLRIYAGHLADVDCVKFHPNSNYLATGSTDKT 449
Query: 104 VQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEH 163
V+L+ +R F GH V ++ F+ + ++ S +D +KLWD+ + + H
Sbjct: 450 VRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGEDQRLKLWDLASGTLYKELRGH 509
Query: 164 SDYVRCGCASKLNPD--LFITGSYDHTVKMFDARTS 197
+D + + +PD L + S D++V+++D R +
Sbjct: 510 TDNI---TSLTFSPDSGLIASASMDNSVRVWDIRNT 542
Score = 52.4 bits (124), Expect = 1e-06
Identities = 25/114 (21%), Positives = 53/114 (46%)
Query: 41 VSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSE 100
V V F P Y + + ++ ++ F+ + F +G+ L + E
Sbjct: 429 VDCVKFHPNSNYLATGSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAFSPNGKYLASAGE 488
Query: 101 DGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNS 154
D ++L+D++ ++ GHT + ++ F+ D + S + D +V++WDI N+
Sbjct: 489 DQRLKLWDLASGTLYKELRGHTDNITSLTFSPDSGLIASASMDNSVRVWDIRNT 542
Score = 31.6 bits (70), Expect = 1.8
Identities = 36/159 (22%), Positives = 63/159 (39%), Gaps = 10/159 (6%)
Query: 118 FEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNP 177
F + ++T + + D + +G D+ +KLW + SK++ + D R A +
Sbjct: 264 FYNTEQLLNTAEISPDSKLLAAGFDNSCIKLWSL-RSKKLKSEPHQVDVSRIHLACDI-- 320
Query: 178 DLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKG 237
+ + +A T +L G + L S GLL + ++ WD L
Sbjct: 321 ------LEEEDDEDDNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWD-LGS 373
Query: 238 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYS 276
V + H V L +S SGS DR +++S
Sbjct: 374 FTNTVLYQGHAYPVWDLDISPYSLYFASGSHDRTARLWS 412
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 80.9 bits (198), Expect = 3e-15
Identities = 63/240 (26%), Positives = 105/240 (43%), Gaps = 52/240 (21%)
Query: 91 DGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
DG+ ++GS DG ++L+D++ R+F GHTK V +V F++D +VSG+ D T+KLW+
Sbjct: 74 DGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLWN 133
Query: 151 -IPNSKEILTFKEHSDYVRC---------------------------GCASKLN------ 176
+ K + + HS++V C C K N
Sbjct: 134 TLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTG 193
Query: 177 --------PD--LFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGG 226
PD L +G D ++D + + +++ G + ++ P+ L +A G
Sbjct: 194 YLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG 253
Query: 227 RYVKVWDM--------LKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTT 278
+K+WD+ LK + S K T L S+ GQ L +G D V+V+ T
Sbjct: 254 PSIKIWDLEGKIIVDELKQEVISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVT 313
Score = 54.7 bits (130), Expect = 2e-07
Identities = 47/179 (26%), Positives = 80/179 (44%), Gaps = 7/179 (3%)
Query: 114 PLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCAS 173
P R GH+ V V ++D +SG+ D T++LWD+ F H+ V S
Sbjct: 55 PQRALRGHSHFVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFS 114
Query: 174 KLNPDLFITGSYDHTVKMFDAR--TSESVLSVEHGQPVESVLLFP--SGGLLVSAG-GRY 228
N + ++GS D T+K+++ +V H + V V P S ++VS G +
Sbjct: 115 SDNRQI-VSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKL 173
Query: 229 VKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFD 287
VKVW+ L +L + H + + +S G SG D + ++ K +++ D
Sbjct: 174 VKVWN-LANCKLKTNHIGHTGYLNTVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLD 231
Score = 43.1 bits (100), Expect = 6e-04
Identities = 31/126 (24%), Positives = 57/126 (45%), Gaps = 8/126 (6%)
Query: 159 TFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE------HGQPVESV 212
T K H+ +V + PD+ ++ S D T+ M+ E+ + H V V
Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDV 69
Query: 213 LLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRK 271
++ G +S +++WD L G H K V + SS ++++SGS D+
Sbjct: 70 VISSDGQFALSGSWDGTLRLWD-LTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKT 128
Query: 272 VKVYST 277
+K+++T
Sbjct: 129 IKLWNT 134
Score = 30.8 bits (68), Expect = 3.1
Identities = 17/65 (26%), Positives = 35/65 (53%), Gaps = 2/65 (3%)
Query: 87 TFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTV 146
T DG L +G +DG L+D++ L +G ++ + F+ ++Y + + A ++
Sbjct: 199 TVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCA-ATGPSI 256
Query: 147 KLWDI 151
K+WD+
Sbjct: 257 KIWDL 261
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 80.9 bits (198), Expect = 3e-15
Identities = 60/196 (30%), Positives = 93/196 (47%), Gaps = 7/196 (3%)
Query: 85 CATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDY 144
C F D +++ + S D L+DI F GH+ V ++ D VSGA D
Sbjct: 148 CCRFLDDNQIITS-SGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDA 206
Query: 145 TVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE 204
++KLWD+ +S TF H + A N F TGS D T ++FD R + +L
Sbjct: 207 SIKLWDVRDSMCRQTFIGHESDIN-AVAFFPNGYAFTTGSDDATCRLFDLRADQELLMYS 265
Query: 205 HGQ---PVESVLLFPSGGLLVSAGGRY-VKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSG 260
H + SV SG LL++ + +WD +KG + V L H V+CL ++ G
Sbjct: 266 HDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGV-LAGHDNRVSCLGVTDDG 324
Query: 261 QRLLSGSLDRKVKVYS 276
+ +GS D +K+++
Sbjct: 325 MAVATGSWDSFLKIWN 340
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 79.3 bits (194), Expect = 8e-15
Identities = 54/199 (27%), Positives = 92/199 (46%), Gaps = 8/199 (4%)
Query: 89 RQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKL 148
+ GRLL G +D V L+ I+ + GHT V +V + +V+G+ ++++
Sbjct: 30 KASGRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVRLNTPEELIVAGSQSGSIRV 89
Query: 149 WDIPNSKEILTFKEHSDYVRCGCASKLNP--DLFITGSYDHTVKMFDARTSESVLSVE-H 205
WD+ +K + T H + C+ +P + +GS D +K++D R V H
Sbjct: 90 WDLEAAKILRTLMGHKANI---CSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGH 146
Query: 206 GQPVESVLLFPSGGLLVSAGGRY-VKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLL 264
Q V + P G L SA + VK+WD L G+++ H V + + L
Sbjct: 147 SQAVRCLRFSPDGKWLASAADDHTVKLWD-LTAGKMMSEFPGHTGPVNVVEFHPNEYLLA 205
Query: 265 SGSLDRKVKVYSTTSYKVV 283
SGS DR ++ + ++VV
Sbjct: 206 SGSSDRTIRFWDLEKFQVV 224
Score = 78.2 bits (191), Expect = 2e-14
Identities = 56/186 (30%), Positives = 92/186 (49%), Gaps = 9/186 (4%)
Query: 94 LLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPN 153
L+VAGS+ G ++++D+ LR GH + ++DF V SG+ D +KLWDI
Sbjct: 77 LIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRR 136
Query: 154 SKEILTFKEHSDYVRCGCASKLNPD--LFITGSYDHTVKMFDARTSESVLSVE-HGQPVE 210
+ ++ HS VRC + +PD + + DHTVK++D + + H PV
Sbjct: 137 KGCVFRYRGHSQAVRC---LRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVN 193
Query: 211 SVLLFPSGGLLVS-AGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 269
V P+ LL S + R ++ WD+ K Q++ ++ V + + G L SG D
Sbjct: 194 VVEFHPNEYLLASGSSDRTIRFWDLEK-FQVVSCIEGEPGPVRSVLFNPDGCCLYSGCQD 252
Query: 270 RKVKVY 275
++VY
Sbjct: 253 -SLRVY 257
Score = 77.8 bits (190), Expect = 2e-14
Identities = 51/170 (30%), Positives = 83/170 (48%), Gaps = 2/170 (1%)
Query: 55 AVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAP 114
A + S I ++ + + ++T K F G + +GS+D ++L+DI +
Sbjct: 80 AGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGC 139
Query: 115 LRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASK 174
+ ++ GH++AV + F+ D + S ADD+TVKLWD+ K + F H+ V
Sbjct: 140 VFRYRGHSQAVRCLRFSPDGKWLASAADDHTVKLWDLTAGKMMSEFPGHTGPVNV-VEFH 198
Query: 175 LNPDLFITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLLFPSGGLLVS 223
N L +GS D T++ +D + V +E PV SVL P G L S
Sbjct: 199 PNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDGCCLYS 248
Score = 59.7 bits (143), Expect = 6e-09
Identities = 32/138 (23%), Positives = 66/138 (47%), Gaps = 3/138 (2%)
Query: 41 VSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSE 100
+ +DF P + + + + I ++ + + + C F DG+ L + ++
Sbjct: 108 ICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGHSQAVRCLRFSPDGKWLASAAD 167
Query: 101 DGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTF 160
D V+L+D++ + +F GHT V+ V+F ++Y + SG+ D T++ WD+ + +
Sbjct: 168 DHTVKLWDLTAGKMMSEFPGHTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCI 227
Query: 161 KEHSDYVRCGCASKLNPD 178
+ VR + NPD
Sbjct: 228 EGEPGPVR---SVLFNPD 242
Score = 35.4 bits (80), Expect = 0.13
Identities = 27/108 (25%), Positives = 53/108 (49%), Gaps = 4/108 (3%)
Query: 203 VEHGQPVESVLLFPSGGLLVSAGGR--YVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSG 260
V H V S++L + G L++ GG V +W + K ++SL H V + L++
Sbjct: 17 VAHASNVSSLVLGKASGRLLATGGDDCRVNLWSINK-PNCIMSLTGHTSPVESVRLNTPE 75
Query: 261 QRLLSGSLDRKVKVYSTTSYKVVHS-FDYAASILSLALAHEDETIVVG 307
+ +++GS ++V+ + K++ + + A+I SL E + G
Sbjct: 76 ELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDFHPYGEFVASG 123
>gi|102470001 PQQ repeat and WD repeat domain containing [Homo
sapiens]
Length = 472
Score = 79.0 bits (193), Expect = 1e-14
Identities = 66/241 (27%), Positives = 108/241 (44%), Gaps = 19/241 (7%)
Query: 69 SQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKA-VHT 127
S+ P K S + F D L++GS D V+L+D + +R FE KA V
Sbjct: 91 SKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAPVVE 150
Query: 128 VDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPD--LFITG-S 184
T D V++ + D TV+ WD+ K + + + V C K +PD ++G
Sbjct: 151 CSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSC----KFSPDGKYVVSGFD 206
Query: 185 YDHTVKMFDAR--TSESVLSVEHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLL 241
DH + + DA T+ SV+ H + + S P + S R +K+WD+ LL
Sbjct: 207 VDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTSQATLL 266
Query: 242 VSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHS--FDYAASILSLALAH 299
K H ++ C + SG L + S D+ +K+++ VH+ F + ++L H
Sbjct: 267 TITKAHSNAISNCCFTFSGHFLCTSSWDKNLKIWN------VHTGEFRNCGACVTLMQGH 320
Query: 300 E 300
E
Sbjct: 321 E 321
Score = 76.6 bits (187), Expect = 5e-14
Identities = 56/196 (28%), Positives = 88/196 (44%), Gaps = 11/196 (5%)
Query: 108 DISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYV 167
D + P + GH AV T F D ++SG+ D TVKLWD + + F+
Sbjct: 88 DPLSKIPFKILSGHEHAVSTCHFCVDDTKLLSGSYDCTVKLWDPVDGSVVRDFEHRPKAP 147
Query: 168 RCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGR 227
C+ + I SYD TV+ +D T + + V + + S P G +VS
Sbjct: 148 VVECSITGDSSRVIAASYDKTVRAWDLETGKLLWKVRYDTFIVSCKFSPDGKYVVSGFDV 207
Query: 228 YVKVWDMLKGGQLLVS-LKNHH-KTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHS 285
+ M VS +K+HH +++T C QR+ S SLDR +K++ TS
Sbjct: 208 DHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRCIKIWDVTS------ 261
Query: 286 FDYAASILSLALAHED 301
A++L++ AH +
Sbjct: 262 ---QATLLTITKAHSN 274
Score = 71.6 bits (174), Expect = 2e-12
Identities = 54/200 (27%), Positives = 97/200 (48%), Gaps = 13/200 (6%)
Query: 88 FRQDGRLLVAGSE-DGGVQLFDISGRAPLRQFEGH-TKAVHTVDFTADKYHVVSGADDYT 145
F DG+ +V+G + D G+ + D + + H T+++ + F D V S + D
Sbjct: 194 FSPDGKYVVSGFDVDHGICIMDAENITTVSVIKDHHTRSITSCCFDPDSQRVASVSLDRC 253
Query: 146 VKLWDIPNSKEILTF-KEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSE------ 198
+K+WD+ + +LT K HS+ + C + T S+D +K+++ T E
Sbjct: 254 IKIWDVTSQATLLTITKAHSNAI-SNCCFTFSGHFLCTSSWDKNLKIWNVHTGEFRNCGA 312
Query: 199 -SVLSVEHGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCL 256
L H V S L+S G R V +WD+ +G + L SLK H+ V + +
Sbjct: 313 CVTLMQGHEGSVSSCHFARDSSFLISGGFDRTVAIWDVAEGYRKL-SLKGHNDWVMDVAI 371
Query: 257 SSSGQRLLSGSLDRKVKVYS 276
S++ + +LS S DR +++++
Sbjct: 372 SNNKKWILSASKDRTMRLWN 391
Score = 38.5 bits (88), Expect = 0.015
Identities = 20/70 (28%), Positives = 36/70 (51%)
Query: 88 FRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVK 147
F +D L++G D V ++D++ +GH V V + +K ++S + D T++
Sbjct: 329 FARDSSFLISGGFDRTVAIWDVAEGYRKLSLKGHNDWVMDVAISNNKKWILSASKDRTMR 388
Query: 148 LWDIPNSKEI 157
LW+I EI
Sbjct: 389 LWNIEEIDEI 398
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit
[Homo sapiens]
Length = 340
Score = 77.8 bits (190), Expect = 2e-14
Identities = 60/196 (30%), Positives = 91/196 (46%), Gaps = 7/196 (3%)
Query: 85 CATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDY 144
C F D ++ V S D L+DI F GH+ V ++ + D VSGA D
Sbjct: 148 CCRFLDDSQI-VTSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDA 206
Query: 145 TVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE 204
+ KLWDI + +F H + + N F TGS D T ++FD R + +L
Sbjct: 207 SSKLWDIRDGMCRQSFTGHVSDIN-AVSFFPNGYAFATGSDDATCRLFDLRADQELLLYS 265
Query: 205 HGQ---PVESVLLFPSGGLLVSAGGRY-VKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSG 260
H + SV SG LL++ + VWD LKG + V L H V+CL ++ G
Sbjct: 266 HDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDTLKGDRAGV-LAGHDNRVSCLGVTDDG 324
Query: 261 QRLLSGSLDRKVKVYS 276
+ +GS D +++++
Sbjct: 325 MAVATGSWDSFLRIWN 340
Score = 59.3 bits (142), Expect = 8e-09
Identities = 54/232 (23%), Positives = 99/232 (42%), Gaps = 13/232 (5%)
Query: 55 AVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAP 114
+ + ++ I+ Y+ + + G + G D ++++ R
Sbjct: 72 SASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCAYAPSGNYVACGGLDNICSIYNLKTREG 131
Query: 115 ----LRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCG 170
R+ GHT + F D +V+ + D T LWDI +++ TF HS V
Sbjct: 132 NVRVSRELPGHTGYLSCCRFLDDS-QIVTSSGDTTCALWDIETAQQTTTFTGHSGDVM-- 188
Query: 171 CASKLNPDL--FITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLLFPSG-GLLVSAGG 226
+ L+PD+ F++G+ D + K++D R S H + +V FP+G +
Sbjct: 189 -SLSLSPDMRTFVSGACDASSKLWDIRDGMCRQSFTGHVSDINAVSFFPNGYAFATGSDD 247
Query: 227 RYVKVWDMLKGGQLLV-SLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYST 277
+++D+ +LL+ S N +T + S SG+ LL+G D V+ T
Sbjct: 248 ATCRLFDLRADQELLLYSHDNIICGITSVAFSKSGRLLLAGYDDFNCNVWDT 299
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 75.5 bits (184), Expect = 1e-13
Identities = 61/257 (23%), Positives = 112/257 (43%), Gaps = 24/257 (9%)
Query: 41 VSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSE 100
V++V F P + + + I ++ + + +T D+ +F G+LL + S
Sbjct: 111 VTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDHSGKLLASCSA 170
Query: 101 DGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTF 160
D ++L+D G +R GH V +V + H+VS + D T+K+W++ + TF
Sbjct: 171 DMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTGYCVKTF 230
Query: 161 KEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSV-EHGQPVESVLLFPSGG 219
H ++VR + L + S D TV+++ T E + EH VE + P
Sbjct: 231 TGHREWVRM-VRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVECISWAPESS 289
Query: 220 ---------------------LLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSS 258
LL + + +K+WD + G L++L H V + S
Sbjct: 290 YSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWD-VSTGMCLMTLVGHDNWVRGVLFHS 348
Query: 259 SGQRLLSGSLDRKVKVY 275
G+ +LS + D+ ++V+
Sbjct: 349 GGKFILSCADDKTLRVW 365
Score = 70.9 bits (172), Expect = 3e-12
Identities = 64/258 (24%), Positives = 114/258 (44%), Gaps = 24/258 (9%)
Query: 40 AVSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGS 99
+V + F + +A I ++ E I+T +G +V+ S
Sbjct: 152 SVQDISFDHSGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSAS 211
Query: 100 EDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILT 159
D ++++++ ++ F GH + V V D + S ++D TV++W + +
Sbjct: 212 RDKTIKMWEVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAE 271
Query: 160 FKEHSDYVRC----------------GCASKLN--PDLF-ITGSYDHTVKMFDARTSESV 200
+EH V C G +K + P F ++GS D T+KM+D T +
Sbjct: 272 LREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCL 331
Query: 201 LS-VEHGQPVESVLLFPSGG--LLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLS 257
++ V H V V LF SGG +L A + ++VWD K + + +L H VT L
Sbjct: 332 MTLVGHDNWVRGV-LFHSGGKFILSCADDKTLRVWD-YKNKRCMKTLNAHEHFVTSLDFH 389
Query: 258 SSGQRLLSGSLDRKVKVY 275
+ +++GS+D+ VKV+
Sbjct: 390 KTAPYVVTGSVDQTVKVW 407
Score = 59.3 bits (142), Expect = 8e-09
Identities = 39/135 (28%), Positives = 65/135 (48%), Gaps = 3/135 (2%)
Query: 63 HIYGRYSQEPIKTFSRFKDTAYCATFR--QDGRLLVAGSEDGGVQLFDISGRAPLRQFEG 120
H+ S P ++S + T + + G L++GS D ++++D+S L G
Sbjct: 277 HVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMWDVSTGMCLMTLVG 336
Query: 121 HTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLF 180
H V V F + ++S ADD T+++WD N + + T H +V K P
Sbjct: 337 HDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNKRCMKTLNAHEHFVTSLDFHKTAP-YV 395
Query: 181 ITGSYDHTVKMFDAR 195
+TGS D TVK+++ R
Sbjct: 396 VTGSVDQTVKVWECR 410
Score = 57.4 bits (137), Expect = 3e-08
Identities = 44/158 (27%), Positives = 79/158 (50%), Gaps = 4/158 (2%)
Query: 120 GHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDL 179
GH V V F +VS ++D T+K+WD T K H+D V+ + + L
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQ-DISFDHSGKL 164
Query: 180 FITGSYDHTVKMFDARTSESVLSVE-HGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKG 237
+ S D T+K++D + E + ++ H V SV + P+G +VSA + +K+W+ ++
Sbjct: 165 LASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE-VQT 223
Query: 238 GQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVY 275
G + + H + V + + G + S S D+ V+V+
Sbjct: 224 GYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 39.7 bits (91), Expect = 0.007
Identities = 27/95 (28%), Positives = 46/95 (48%), Gaps = 5/95 (5%)
Query: 205 HGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRL 263
H PV V+ P ++VSA +KVWD + G +LK H +V + SG+ L
Sbjct: 107 HRSPVTRVIFHPVFSVMVSASEDATIKVWDY-ETGDFERTLKGHTDSVQDISFDHSGKLL 165
Query: 264 LSGSLDRKVKVYSTTSY---KVVHSFDYAASILSL 295
S S D +K++ + + +H D+ S +++
Sbjct: 166 ASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAI 200
>gi|157266266 WD repeat domain 86 [Homo sapiens]
Length = 376
Score = 73.9 bits (180), Expect = 3e-13
Identities = 54/191 (28%), Positives = 90/191 (47%), Gaps = 6/191 (3%)
Query: 85 CATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDY 144
CA G LLV GS DG +++ ++ + GHT AV + + +G+ D
Sbjct: 156 CAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDA 215
Query: 145 TVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE 204
T++ WDI + +++ F+EH V C +L L +GS D TVK + A T E V +
Sbjct: 216 TIRAWDILSGEQLRVFREHRGSVIC---LELVNRLVYSGSADRTVKCWLADTGECVRTFT 272
Query: 205 HGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLL 264
+ S L + +G L +G + +D + G+L + H T C+ GQ L
Sbjct: 273 AHRRNVSALKYHAGTLFTGSGDACARAFD-AQSGELRRVFRGH--TFIINCIQVHGQVLY 329
Query: 265 SGSLDRKVKVY 275
+ S D ++++
Sbjct: 330 TASHDGALRLW 340
Score = 54.7 bits (130), Expect = 2e-07
Identities = 55/230 (23%), Positives = 96/230 (41%), Gaps = 31/230 (13%)
Query: 91 DGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
DG+ L+ GSEDG +L+ + +GH V + S D T++ WD
Sbjct: 26 DGQRLLTGSEDGTARLWSTADGQCCALLQGHESYVTFCQLEDEAAFTCSA--DCTIRRWD 83
Query: 151 IPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSES----------V 200
+ + + ++ H+ V + N LF + SYD T +++ + V
Sbjct: 84 VLTGQCLQVYRGHTSIVNRILVA--NNQLF-SSSYDRTARVWSVDKGQMSREFRGHRNCV 140
Query: 201 LSVEHGQPVESVLLFPS---------GGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKT 250
L++ + P + PS GGLLV+ KVW + G +L+ H
Sbjct: 141 LTLAYSAPWD----LPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGC-CHQTLRGHTGA 195
Query: 251 VTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF-DYAASILSLALAH 299
V CL L + G +GS D ++ + S + + F ++ S++ L L +
Sbjct: 196 VLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRVFREHRGSVICLELVN 245
Score = 52.8 bits (125), Expect = 8e-07
Identities = 47/218 (21%), Positives = 88/218 (40%), Gaps = 19/218 (8%)
Query: 111 GRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCG 170
G + LR H ++ + + D +++G++D T +LW + + + H YV
Sbjct: 4 GGSALRVCADHRGGINWLSLSPDGQRLLTGSEDGTARLWSTADGQCCALLQGHESYV--- 60
Query: 171 CASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGLLVSAGGRYVK 230
+L + T S D T++ +D T + + + + +L + L S+ R +
Sbjct: 61 TFCQLEDEAAFTCSADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQLFSSSYDRTAR 120
Query: 231 VWDMLKGGQLLVSLKNHHKTVTCLCLS--------------SSGQRLLSGSLDRKVKVYS 276
VW + K GQ+ + H V L S ++G L++GS D KV+
Sbjct: 121 VWSVDK-GQMSREFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQ 179
Query: 277 TTSYKVVHSF-DYAASILSLALAHEDETIVVGMTNGIL 313
S + + ++L L L T G T+ +
Sbjct: 180 VASGCCHQTLRGHTGAVLCLVLDTPGHTAFTGSTDATI 217
Score = 52.0 bits (123), Expect = 1e-06
Identities = 50/203 (24%), Positives = 87/203 (42%), Gaps = 20/203 (9%)
Query: 99 SEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEIL 158
S D ++ +D+ L+ + GHT V+ + ++ + S + D T ++W + +
Sbjct: 74 SADCTIRRWDVLTGQCLQVYRGHTSIVNRILVANNQ--LFSSSYDRTARVWSVDKGQMSR 131
Query: 159 TFKEHSDYV------------RCGCASKLNPD-LFITGSYDHTVKMFDARTS--ESVLSV 203
F+ H + V CA + L +TGS D T K++ + L
Sbjct: 132 EFRGHRNCVLTLAYSAPWDLPSTPCAEEAAAGGLLVTGSTDGTAKVWQVASGCCHQTLRG 191
Query: 204 EHGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRL 263
G + VL P + ++ WD+L G QL V + H +V CL L + + +
Sbjct: 192 HTGAVLCLVLDTPGHTAFTGSTDATIRAWDILSGEQLRV-FREHRGSVICLELVN--RLV 248
Query: 264 LSGSLDRKVKVYSTTSYKVVHSF 286
SGS DR VK + + + V +F
Sbjct: 249 YSGSADRTVKCWLADTGECVRTF 271
>gi|61743926 F-box and WD repeat domain containing 7 isoform 3 [Homo
sapiens]
Length = 589
Score = 73.2 bits (178), Expect = 5e-13
Identities = 46/157 (29%), Positives = 84/157 (53%), Gaps = 9/157 (5%)
Query: 91 DGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
DGR +V+G+ D V+++D L +GHT V+++ F D HVVSG+ D ++++WD
Sbjct: 392 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 449
Query: 151 IPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE---HGQ 207
+ I T H +L ++ ++G+ D TVK++D +T + + +++ Q
Sbjct: 450 VETGNCIHTLTGHQSLT---SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 506
Query: 208 PVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSL 244
+ L F ++ S+ VK+WD LK G+ + +L
Sbjct: 507 SAVTCLQFNKNFVITSSDDGTVKLWD-LKTGEFIRNL 542
Score = 67.8 bits (164), Expect = 2e-11
Identities = 68/263 (25%), Positives = 120/263 (45%), Gaps = 15/263 (5%)
Query: 92 GRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI 151
G +V+GS+D ++++ LR GHT V + + ++SG+ D T+K+W+
Sbjct: 273 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--IISGSTDRTLKVWNA 330
Query: 152 PNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVES 211
+ I T H+ VRC L+ ++GS D T++++D T + L V G V +
Sbjct: 331 ETGECIHTLYGHTSTVRC---MHLHEKRVVSGSRDATLRVWDIETGQ-CLHVLMGH-VAA 385
Query: 212 VLLFPSGGLLVSAGGR--YVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 269
V G V +G VKVWD + L +L+ H V L G ++SGSLD
Sbjct: 386 VRCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRV--YSLQFDGIHVVSGSLD 442
Query: 270 RKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKESL-- 327
++V+ + +H+ S+ S + +D +V G + + + K+ ++L
Sbjct: 443 TSIRVWDVETGNCIHTLTGHQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQG 501
Query: 328 PRRRRPAYRTFIKGKNYMKQRDD 350
P + + A KN++ D
Sbjct: 502 PNKHQSAVTCLQFNKNFVITSSD 524
Score = 30.8 bits (68), Expect = 3.1
Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 244 LKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF-DYAASILSLALAHEDE 302
LK H V CL G R++SGS D +KV+S + K + + + + S + D
Sbjct: 258 LKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDN 314
Query: 303 TIVVGMTNGILSV 315
I+ G T+ L V
Sbjct: 315 IIISGSTDRTLKV 327
>gi|16117781 F-box and WD repeat domain containing 7 isoform 1 [Homo
sapiens]
Length = 707
Score = 73.2 bits (178), Expect = 5e-13
Identities = 46/157 (29%), Positives = 84/157 (53%), Gaps = 9/157 (5%)
Query: 91 DGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
DGR +V+G+ D V+++D L +GHT V+++ F D HVVSG+ D ++++WD
Sbjct: 510 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 567
Query: 151 IPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE---HGQ 207
+ I T H +L ++ ++G+ D TVK++D +T + + +++ Q
Sbjct: 568 VETGNCIHTLTGHQSLT---SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 624
Query: 208 PVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSL 244
+ L F ++ S+ VK+WD LK G+ + +L
Sbjct: 625 SAVTCLQFNKNFVITSSDDGTVKLWD-LKTGEFIRNL 660
Score = 67.8 bits (164), Expect = 2e-11
Identities = 68/263 (25%), Positives = 120/263 (45%), Gaps = 15/263 (5%)
Query: 92 GRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI 151
G +V+GS+D ++++ LR GHT V + + ++SG+ D T+K+W+
Sbjct: 391 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--IISGSTDRTLKVWNA 448
Query: 152 PNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVES 211
+ I T H+ VRC L+ ++GS D T++++D T + L V G V +
Sbjct: 449 ETGECIHTLYGHTSTVRC---MHLHEKRVVSGSRDATLRVWDIETGQ-CLHVLMGH-VAA 503
Query: 212 VLLFPSGGLLVSAGGR--YVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 269
V G V +G VKVWD + L +L+ H V L G ++SGSLD
Sbjct: 504 VRCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRV--YSLQFDGIHVVSGSLD 560
Query: 270 RKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKESL-- 327
++V+ + +H+ S+ S + +D +V G + + + K+ ++L
Sbjct: 561 TSIRVWDVETGNCIHTLTGHQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQG 619
Query: 328 PRRRRPAYRTFIKGKNYMKQRDD 350
P + + A KN++ D
Sbjct: 620 PNKHQSAVTCLQFNKNFVITSSD 642
Score = 30.8 bits (68), Expect = 3.1
Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 244 LKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF-DYAASILSLALAHEDE 302
LK H V CL G R++SGS D +KV+S + K + + + + S + D
Sbjct: 376 LKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDN 432
Query: 303 TIVVGMTNGILSV 315
I+ G T+ L V
Sbjct: 433 IIISGSTDRTLKV 445
>gi|16117779 F-box and WD repeat domain containing 7 isoform 2 [Homo
sapiens]
Length = 627
Score = 73.2 bits (178), Expect = 5e-13
Identities = 46/157 (29%), Positives = 84/157 (53%), Gaps = 9/157 (5%)
Query: 91 DGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWD 150
DGR +V+G+ D V+++D L +GHT V+++ F D HVVSG+ D ++++WD
Sbjct: 430 DGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQF--DGIHVVSGSLDTSIRVWD 487
Query: 151 IPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE---HGQ 207
+ I T H +L ++ ++G+ D TVK++D +T + + +++ Q
Sbjct: 488 VETGNCIHTLTGHQSLT---SGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQ 544
Query: 208 PVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSL 244
+ L F ++ S+ VK+WD LK G+ + +L
Sbjct: 545 SAVTCLQFNKNFVITSSDDGTVKLWD-LKTGEFIRNL 580
Score = 67.8 bits (164), Expect = 2e-11
Identities = 68/263 (25%), Positives = 120/263 (45%), Gaps = 15/263 (5%)
Query: 92 GRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDI 151
G +V+GS+D ++++ LR GHT V + + ++SG+ D T+K+W+
Sbjct: 311 GNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNI--IISGSTDRTLKVWNA 368
Query: 152 PNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVEHGQPVES 211
+ I T H+ VRC L+ ++GS D T++++D T + L V G V +
Sbjct: 369 ETGECIHTLYGHTSTVRC---MHLHEKRVVSGSRDATLRVWDIETGQ-CLHVLMGH-VAA 423
Query: 212 VLLFPSGGLLVSAGGR--YVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLD 269
V G V +G VKVWD + L +L+ H V L G ++SGSLD
Sbjct: 424 VRCVQYDGRRVVSGAYDFMVKVWDP-ETETCLHTLQGHTNRV--YSLQFDGIHVVSGSLD 480
Query: 270 RKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGILSVKHRKSEAKKESL-- 327
++V+ + +H+ S+ S + +D +V G + + + K+ ++L
Sbjct: 481 TSIRVWDVETGNCIHTLTGHQSLTS-GMELKDNILVSGNADSTVKIWDIKTGQCLQTLQG 539
Query: 328 PRRRRPAYRTFIKGKNYMKQRDD 350
P + + A KN++ D
Sbjct: 540 PNKHQSAVTCLQFNKNFVITSSD 562
Score = 30.8 bits (68), Expect = 3.1
Identities = 23/73 (31%), Positives = 35/73 (47%), Gaps = 4/73 (5%)
Query: 244 LKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSF-DYAASILSLALAHEDE 302
LK H V CL G R++SGS D +KV+S + K + + + + S + D
Sbjct: 296 LKGHDDHVIT-CLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQM--RDN 352
Query: 303 TIVVGMTNGILSV 315
I+ G T+ L V
Sbjct: 353 IIISGSTDRTLKV 365
>gi|4504053 guanine nucleotide-binding protein, beta-3 subunit [Homo
sapiens]
Length = 340
Score = 72.8 bits (177), Expect = 7e-13
Identities = 55/196 (28%), Positives = 88/196 (44%), Gaps = 7/196 (3%)
Query: 85 CATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDY 144
C F D + V S D L+DI F GHT ++ + D +SGA D
Sbjct: 148 CCRFLDDNNI-VTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDA 206
Query: 145 TVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE 204
+ KLWD+ TF H + C N + TGS D + ++FD R + ++
Sbjct: 207 SAKLWDVREGTCRQTFTGHESDINAICFFP-NGEAICTGSDDASCRLFDLRADQELICFS 265
Query: 205 HGQ---PVESVLLFPSGGLLVSAGGRY-VKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSG 260
H + SV SG LL + + VWD +K ++ + L H V+CL +++ G
Sbjct: 266 HESIICGITSVAFSLSGRLLFAGYDDFNCNVWDSMKSERVGI-LSGHDNRVSCLGVTADG 324
Query: 261 QRLLSGSLDRKVKVYS 276
+ +GS D +K+++
Sbjct: 325 MAVATGSWDSFLKIWN 340
Score = 56.6 bits (135), Expect = 5e-08
Identities = 57/265 (21%), Positives = 105/265 (39%), Gaps = 22/265 (8%)
Query: 60 SRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFE 119
S + + GR +T Y + D +LLV+ S+DG + ++D +
Sbjct: 35 SGLEVVGRVQMRTRRTLRGHLAKIYAMHWATDSKLLVSASQDGKLIVWDSYTTNKVHAIP 94
Query: 120 GHTKAVHTVDFTADKYHVVSGADDYTVKLWDIP----NSKEILTFKEHSDYVRCGCASKL 175
+ V T + V G D ++++ N K H+ Y+ C L
Sbjct: 95 LRSSWVMTCAYAPSGNFVACGGLDNMCSIYNLKSREGNVKVSRELSAHTGYL--SCCRFL 152
Query: 176 NPDLFITGSYDHTVKMFDART-SESVLSVEHGQPVESVLLFPSGGLLVS-AGGRYVKVWD 233
+ + +T S D T ++D T + + V H S+ + P L +S A K+WD
Sbjct: 153 DDNNIVTSSGDTTCALWDIETGQQKTVFVGHTGDCMSLAVSPDFNLFISGACDASAKLWD 212
Query: 234 MLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASIL 293
++ G + H + +C +G+ + +GS D ++ FD A
Sbjct: 213 -VREGTCRQTFTGHESDINAICFFPNGEAICTGSDDASCRL-----------FDLRADQE 260
Query: 294 SLALAHEDETIVVGMTNGILSVKHR 318
+ +H E+I+ G+T+ S+ R
Sbjct: 261 LICFSH--ESIICGITSVAFSLSGR 283
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 70.5 bits (171), Expect = 4e-12
Identities = 74/312 (23%), Positives = 131/312 (41%), Gaps = 27/312 (8%)
Query: 30 KTPVQIK---EFGAVSKVD---FSPQPPYNYAVTASSRIHIYGRYSQEPIK--------T 75
K P Q+ +FG S V+ FSP Y + I ++ + + K
Sbjct: 200 KFPTQLSRHIKFGQKSHVECARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKYQAQDN 259
Query: 76 FSRFKDTAYCATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFE-GHTKAVHTVDFTADK 134
F D C F +D +L G++DG ++++ I LR+FE H+K V + F+ D
Sbjct: 260 FMMMDDAVLCMCFSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDS 319
Query: 135 YHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDA 194
++S + D T+++ + + K + F+ HS +V ++ + I+ S D TVK+++
Sbjct: 320 SQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQ-DGHYIISASSDGTVKIWNM 378
Query: 195 RTSE-----SVLSVEHGQ--PVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSL--- 244
+T+E L G V SV+L P R V M GQ++ S
Sbjct: 379 KTTECSNTFKSLGSTAGTDITVNSVILLPKNPEHFVVCNRSNTVVIMNMQGQIVRSFSSG 438
Query: 245 KNHHKTVTCLCLSSSGQRLLSGSLDRKVKVYSTTSYKVVHSFD-YAASILSLALAHEDET 303
K C LS G+ + D + +ST + K+ + + ++ +A
Sbjct: 439 KREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTLTVHEKDVIGIAHHPHQNL 498
Query: 304 IVVGMTNGILSV 315
I +G+L +
Sbjct: 499 IATYSEDGLLKL 510
Score = 43.9 bits (102), Expect = 4e-04
Identities = 37/169 (21%), Positives = 81/169 (47%), Gaps = 18/169 (10%)
Query: 166 YVRCGCASKLNPD--LFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSGGL--- 220
+V C ++ +PD +TGS D +++++ T + +++ Q ++ ++ L
Sbjct: 216 HVEC---ARFSPDGQYLVTGSVDGFIEVWNFTTGKIRKDLKY-QAQDNFMMMDDAVLCMC 271
Query: 221 ------LVSAGGR--YVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQRLLSGSLDRKV 272
+++ G + +KVW + G L + H K VTCL S ++LS S D+ +
Sbjct: 272 FSRDTEMLATGAQDGKIKVWKIQSGQCLRRFERAHSKGVTCLSFSKDSSQILSASFDQTI 331
Query: 273 KVYSTTSYKVVHSFDYAASILSLALAHED-ETIVVGMTNGILSVKHRKS 320
+++ S K + F +S ++ A +D I+ ++G + + + K+
Sbjct: 332 RIHGLKSGKTLKEFRGHSSFVNEATFTQDGHYIISASSDGTVKIWNMKT 380
>gi|4503513 eukaryotic translation initiation factor 3, subunit 2
beta, 36kDa [Homo sapiens]
Length = 325
Score = 69.3 bits (168), Expect = 8e-12
Identities = 56/230 (24%), Positives = 101/230 (43%), Gaps = 10/230 (4%)
Query: 88 FRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVK 147
+ ++G LL ++D V ++ L + GHT AV VD D HV++G+ D + +
Sbjct: 18 YNREGDLLFTVAKDPIVNVWYSVNGERLGTYMGHTGAVWCVDADWDTKHVLTGSADNSCR 77
Query: 148 LWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITG---SYDHTVKMFDARTSESVLSVE 204
LWD K++ K +S CG N +F T Y V FD R + + E
Sbjct: 78 LWDCETGKQLALLKTNSAVRTCGFDFGGNIIMFSTDKQMGYQCFVSFFDLRDPSQIDNNE 137
Query: 205 -------HGQPVESVLLFPSGGLLVSAGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLS 257
+ + S + P G +++ K G++LV++K H + + + LS
Sbjct: 138 PYMKIPCNDSKITSAVWGPLGECIIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLS 197
Query: 258 SSGQRLLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVG 307
++ S D K++ +T+ + +F + S AL+ + +V+G
Sbjct: 198 RDMTMFVTASKDNTAKLFDSTTLEHQKTFRTERPVNSAALSPNYDHVVLG 247
Score = 41.2 bits (95), Expect = 0.002
Identities = 24/91 (26%), Positives = 47/91 (51%), Gaps = 1/91 (1%)
Query: 137 VVSGADDYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDART 196
+++G + + + + + ++ KEHS + S+ + +F+T S D+T K+FD+ T
Sbjct: 161 IIAGHESGELNQYSAKSGEVLVNVKEHSRQINDIQLSR-DMTMFVTASKDNTAKLFDSTT 219
Query: 197 SESVLSVEHGQPVESVLLFPSGGLLVSAGGR 227
E + +PV S L P+ +V GG+
Sbjct: 220 LEHQKTFRTERPVNSAALSPNYDHVVLGGGQ 250
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis)
[Homo sapiens]
Length = 514
Score = 68.6 bits (166), Expect = 1e-11
Identities = 55/231 (23%), Positives = 100/231 (43%), Gaps = 5/231 (2%)
Query: 85 CATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDY 144
C + V GS D ++++D++ GH V V + ++ S +D
Sbjct: 209 CIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDK 268
Query: 145 TVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVLSVE 204
VK WD+ +K I + H V G D+ +T S D T +++D RT SV ++
Sbjct: 269 QVKCWDLEYNKVIRHYHGHLSAV-YGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLS 327
Query: 205 -HGQPVESVLLFPSGGLLVSAG-GRYVKVWDMLKGGQLLVSLKNHHKTVTCLCLSSSGQR 262
H V +V + +++ +++WD++ G+ V+L NH K+V + L
Sbjct: 328 GHTNAVATVRCQAAEPQIITGSHDTTIRLWDLV-AGKTRVTLTNHKKSVRAVVLHPRHYT 386
Query: 263 LLSGSLDRKVKVYSTTSYKVVHSFDYAASILSLALAHEDETIVVGMTNGIL 313
SGS D +K + + + +I++ + D +V G NG +
Sbjct: 387 FASGSPD-NIKQWKFPDGSFIQNLSGHNAIINTLTVNSDGVLVSGADNGTM 436
Score = 67.8 bits (164), Expect = 2e-11
Identities = 64/266 (24%), Positives = 110/266 (41%), Gaps = 18/266 (6%)
Query: 41 VSKVDFSPQPPYNYAVTASSRIHIYGRYSQEPIKTFSRFKDTAYCATFRQDGRLLVAGSE 100
V V S + PY ++ ++ + + I+ + Y +LV S
Sbjct: 249 VRGVIVSTRSPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSR 308
Query: 101 DGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTF 160
D +++D+ +A + GHT AV TV A + +++G+ D T++LWD+ K +T
Sbjct: 309 DSTARIWDVRTKASVHTLSGHTNAVATVRCQAAEPQIITGSHDTTIRLWDLVAGKTRVTL 368
Query: 161 KEHSDYVRCGCASKLNPD--LFITGSYDHTVKMFDARTSESVLSVEHGQPVESVLLFPSG 218
H VR A L+P F +GS D+ +K + + ++ + + L S
Sbjct: 369 TNHKKSVR---AVVLHPRHYTFASGSPDN-IKQWKFPDGSFIQNLSGHNAIINTLTVNSD 424
Query: 219 GLLVS-AGGRYVKVWDMLKGGQLL--------VSLKNHHKTVTCLCLSSSGQRLLSGSLD 269
G+LVS A + +WD G SL + C S RLL+ D
Sbjct: 425 GVLVSGADNGTMHLWDWRTGYNFQRVHAAVQPGSLDSESGIFAC-AFDQSESRLLTAEAD 483
Query: 270 RKVKVY--STTSYKVVHSFDYAASIL 293
+ +KVY T+ + H + I+
Sbjct: 484 KTIKVYREDDTATEETHPVSWKPEII 509
>gi|5729852 guanine nucleotide-binding protein, beta-5 subunit
isoform a [Homo sapiens]
Length = 353
Score = 68.2 bits (165), Expect = 2e-11
Identities = 58/200 (29%), Positives = 91/200 (45%), Gaps = 13/200 (6%)
Query: 85 CATFRQDGRLLVAGSEDGGVQLFDISGRAPLRQFEGHTKAVHTVDFTADK--YHVVSGAD 142
C+ D ++L A S DG L+D+ L+ F GH V +D + VSG
Sbjct: 159 CSFTNSDMQILTA-SGDGTCALWDVESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGC 217
Query: 143 DYTVKLWDIPNSKEILTFKEHSDYVRCGCASKLNPDLFITGSYDHTVKMFDARTSESVL- 201
D +WD+ + + + F+ H + + D F +GS D T +++D R V
Sbjct: 218 DKKAMVWDMRSGQCVQAFETHESDIN-SVRYYPSGDAFASGSDDATCRLYDLRADREVAI 276
Query: 202 ----SVEHGQPVESVLLFPSGGLLVSAGGRY-VKVWDMLKGGQLLVSLKNHHKTVTCLCL 256
S+ G SV SG LL + Y + VWD+LKG ++ + L H V+ L +
Sbjct: 277 YSKESIIFG--ASSVDFSLSGRLLFAGYNDYTINVWDVLKGSRVSI-LFGHENRVSTLRV 333
Query: 257 SSSGQRLLSGSLDRKVKVYS 276
S G SGS D ++V++
Sbjct: 334 SPDGTAFCSGSWDHTLRVWA 353
Score = 54.7 bits (130), Expect = 2e-07
Identities = 50/186 (26%), Positives = 78/186 (41%), Gaps = 20/186 (10%)
Query: 116 RQFEGHTKAVHTVDFTADKYHVVSGADDYTVKLWDIPNSKEILTFKEHSDYVRC----GC 171
R +GH V +D+ DK +VS + D V +WD T KEH+ + C C
Sbjct: 57 RTLKGHGNKVLCMDWCKDKRRIVSSSQDGKVIVWD-----SFTTNKEHAVTMPCTWVMAC 111
Query: 172 ASKLNPDLFITGSYDHTVKMF------DARTSESVLSVEHGQPVESVLLFPSGG--LLVS 223
A + G D+ ++ + + SV S F + +L +
Sbjct: 112 AYAPSGCAIACGGLDNKCSVYPLTFDKNENMAAKKKSVAMHTNYLSACSFTNSDMQILTA 171
Query: 224 AGGRYVKVWDMLKGGQLLVSLKNHHKTVTCLCL--SSSGQRLLSGSLDRKVKVYSTTSYK 281
+G +WD ++ GQLL S H V CL L S +G +SG D+K V+ S +
Sbjct: 172 SGDGTCALWD-VESGQLLQSFHGHGADVLCLDLAPSETGNTFVSGGCDKKAMVWDMRSGQ 230
Query: 282 VVHSFD 287
V +F+
Sbjct: 231 CVQAFE 236
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.136 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,818,877
Number of Sequences: 37866
Number of extensions: 806956
Number of successful extensions: 3621
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 210
Number of HSP's successfully gapped in prelim test: 115
Number of HSP's that attempted gapping in prelim test: 1879
Number of HSP's gapped (non-prelim): 1080
length of query: 518
length of database: 18,247,518
effective HSP length: 107
effective length of query: 411
effective length of database: 14,195,856
effective search space: 5834496816
effective search space used: 5834496816
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.