Search of human proteins with 5032105

Search of human proteins with 5032105

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|5032105 small optic lobes [Homo sapiens]
         (1086 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|5032105 small optic lobes [Homo sapiens]                          2263   0.0  
gi|215490104 calpain 11 [Homo sapiens]                                168   2e-41
gi|38707981 calpain 12 [Homo sapiens]                                 167   5e-41
gi|27765074 calpain 3 isoform c [Homo sapiens]                        167   6e-41
gi|4557405 calpain 3 isoform a [Homo sapiens]                         157   4e-38
gi|27765072 calpain 3 isoform b [Homo sapiens]                        157   4e-38
gi|223468608 calpain 14 [Homo sapiens]                                156   1e-37
gi|12408656 calpain 1, large subunit [Homo sapiens]                   156   1e-37
gi|221554549 calpain 8 [Homo sapiens]                                 155   2e-37
gi|157389005 calpain 2 isoform 1 [Homo sapiens]                       151   3e-36
gi|37577157 calpain 5 [Homo sapiens]                                  146   9e-35
gi|5729758 calpain 9 isoform 1 [Homo sapiens]                         145   2e-34
gi|47078247 calpain 3 isoform f [Homo sapiens]                        144   3e-34
gi|225703100 calpain 2 isoform 2 [Homo sapiens]                       138   3e-32
gi|7705383 calpain 9 isoform 2 [Homo sapiens]                         126   1e-28
gi|89353291 calpain 10 isoform c [Homo sapiens]                       123   8e-28
gi|13186302 calpain 10 isoform a [Homo sapiens]                       123   8e-28
gi|41152101 calpain 13 [Homo sapiens]                                 120   9e-27
gi|7656959 calpain 7 [Homo sapiens]                                   110   9e-24
gi|13186316 calpain 6 [Homo sapiens]                                   96   2e-19
gi|109150431 ring finger protein 31 [Homo sapiens]                     56   2e-07
gi|150418007 RAN binding protein 2 [Homo sapiens]                      55   5e-07
gi|153792074 proline rich 12 [Homo sapiens]                            55   5e-07
gi|56549694 enabled homolog isoform a [Homo sapiens]                   54   6e-07
gi|39930375 enabled homolog isoform b [Homo sapiens]                   54   6e-07
gi|11386183 WAS protein family, member 2 [Homo sapiens]                53   2e-06
gi|122937496 WAS/WASL interacting protein family, member 3 [Homo...    52   3e-06
gi|163965366 nascent polypeptide-associated complex alpha subuni...    50   2e-05
gi|210032580 SET domain containing 1B [Homo sapiens]                   49   3e-05
gi|162329583 cleavage and polyadenylation specific factor 6, 68 ...    49   3e-05

>gi|5032105 small optic lobes [Homo sapiens]
          Length = 1086

 Score = 2263 bits (5863), Expect = 0.0
 Identities = 1086/1086 (100%), Positives = 1086/1086 (100%)

Query: 1    MATVGEWSCVRCTFLNPAGQRQCSICEAPRHKPDLNHILRLSVEEQKWPCARCTFRNFLG 60
            MATVGEWSCVRCTFLNPAGQRQCSICEAPRHKPDLNHILRLSVEEQKWPCARCTFRNFLG
Sbjct: 1    MATVGEWSCVRCTFLNPAGQRQCSICEAPRHKPDLNHILRLSVEEQKWPCARCTFRNFLG 60

Query: 61   KEACEVCGFTPEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPAR 120
            KEACEVCGFTPEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPAR
Sbjct: 61   KEACEVCGFTPEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPAR 120

Query: 121  GQCEDKDEEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPE 180
            GQCEDKDEEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPE
Sbjct: 121  GQCEDKDEEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPE 180

Query: 181  ALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQ 240
            ALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQ
Sbjct: 181  ALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQ 240

Query: 241  NNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELLSGKRLSVLEE 300
            NNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELLSGKRLSVLEE
Sbjct: 241  NNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELLSGKRLSVLEE 300

Query: 301  EATEGGTSRVEAGSSTSGSDIIDLAGDTVRYTPASPSSPDFTTWSCAKCTLRNPTVAPRC 360
            EATEGGTSRVEAGSSTSGSDIIDLAGDTVRYTPASPSSPDFTTWSCAKCTLRNPTVAPRC
Sbjct: 301  EATEGGTSRVEAGSSTSGSDIIDLAGDTVRYTPASPSSPDFTTWSCAKCTLRNPTVAPRC 360

Query: 361  SACGCSKLHGFQEHGEPPTHCPDCGADKPSPCGRSCGRVSSAQKAARVLPERPGQWACPA 420
            SACGCSKLHGFQEHGEPPTHCPDCGADKPSPCGRSCGRVSSAQKAARVLPERPGQWACPA
Sbjct: 361  SACGCSKLHGFQEHGEPPTHCPDCGADKPSPCGRSCGRVSSAQKAARVLPERPGQWACPA 420

Query: 421  CTLLNALRAKHCAACHTPQLLVAQRRGAAPLRRRESMHVEQRRQTDEGEAKALWENIVAF 480
            CTLLNALRAKHCAACHTPQLLVAQRRGAAPLRRRESMHVEQRRQTDEGEAKALWENIVAF
Sbjct: 421  CTLLNALRAKHCAACHTPQLLVAQRRGAAPLRRRESMHVEQRRQTDEGEAKALWENIVAF 480

Query: 481  CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540
            CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR
Sbjct: 481  CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540

Query: 541  PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDD 600
            PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDD
Sbjct: 541  PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEGAYQVRLCKDGTWTTVLVDD 600

Query: 601  MLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLA 660
            MLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLA
Sbjct: 601  MLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLA 660

Query: 661  LQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHAYS 720
            LQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHAYS
Sbjct: 661  LQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHAYS 720

Query: 721  ILDVRDVQGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRGELMPHGSSEGVFWMEYGDF 780
            ILDVRDVQGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRGELMPHGSSEGVFWMEYGDF
Sbjct: 721  ILDVRDVQGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRGELMPHGSSEGVFWMEYGDF 780

Query: 781  VRYFDSVDICKVHSDWQEARVQGCFPSSASAPVGVTALTVLERASLEFALFQEGSRRSDA 840
            VRYFDSVDICKVHSDWQEARVQGCFPSSASAPVGVTALTVLERASLEFALFQEGSRRSDA
Sbjct: 781  VRYFDSVDICKVHSDWQEARVQGCFPSSASAPVGVTALTVLERASLEFALFQEGSRRSDA 840

Query: 841  VDSHLLDLCILVFRATFGSGGHLSLGRLLAHSKRAVKKFVSCDVMLEPGEYAVVCCAFNH 900
            VDSHLLDLCILVFRATFGSGGHLSLGRLLAHSKRAVKKFVSCDVMLEPGEYAVVCCAFNH
Sbjct: 841  VDSHLLDLCILVFRATFGSGGHLSLGRLLAHSKRAVKKFVSCDVMLEPGEYAVVCCAFNH 900

Query: 901  WGPPLPGTPAPQASSPSAGVPRASPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLT 960
            WGPPLPGTPAPQASSPSAGVPRASPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLT
Sbjct: 901  WGPPLPGTPAPQASSPSAGVPRASPEPPGHVLAVYSSRLVMVEPVEAQPTTLADAIILLT 960

Query: 961  ESRGERHEGREGMTCYYLTHGWAGLIVVVENRHPKAYLHVQCDCTDSFNVVSTRGSLRTQ 1020
            ESRGERHEGREGMTCYYLTHGWAGLIVVVENRHPKAYLHVQCDCTDSFNVVSTRGSLRTQ
Sbjct: 961  ESRGERHEGREGMTCYYLTHGWAGLIVVVENRHPKAYLHVQCDCTDSFNVVSTRGSLRTQ 1020

Query: 1021 DSVPPLHRQVLVILSQLEGNAGFSITHRLAHRKAAQAFLSDWTASKGTHSPPLTPEVAGL 1080
            DSVPPLHRQVLVILSQLEGNAGFSITHRLAHRKAAQAFLSDWTASKGTHSPPLTPEVAGL
Sbjct: 1021 DSVPPLHRQVLVILSQLEGNAGFSITHRLAHRKAAQAFLSDWTASKGTHSPPLTPEVAGL 1080

Query: 1081 HGPRPL 1086
            HGPRPL
Sbjct: 1081 HGPRPL 1086


>gi|215490104 calpain 11 [Homo sapiens]
          Length = 739

 Score =  168 bits (426), Expect = 2e-41
 Identities = 115/340 (33%), Positives = 164/340 (48%), Gaps = 43/340 (12%)

Query: 474 WENIVAFCRENNVSFVDDSFPPGPESVGF----PAGDSVQQRVRQWLRPQEI-NCSVFRD 528
           +E + A C      F D  FP  P S+GF    P   +VQ     W RP++I N  +F  
Sbjct: 66  FEELRAACLRKGELFEDPLFPAEPSSLGFKDLGPNSKNVQNI--SWQRPKDIINNPLF-- 121

Query: 529 HRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQV 585
                 +   + P+DI QG+LG+CW L+A+  L   P L+ RV+       +   G +  
Sbjct: 122 ------IMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRGQSFKKNYAGIFHF 175

Query: 586 RLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAI 645
           ++ + G W  V+VDD LP      +     +R + W AL+EKA AKL GSY AL  G  +
Sbjct: 176 QIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSGSYEALSGGSTM 235

Query: 646 EGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDD 705
           EGL   TG   +S  LQ    N          +   +  + E   LMG S         D
Sbjct: 236 EGLEDFTGGVAQSFQLQRPPQN----------LLRLLRKAVERSSLMGCSI----EVTSD 281

Query: 706 SAYESLG---LRPRHAYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSD---EWPHW 755
           S  ES+    L   HAYS+  ++DV    +   L+R+RNPWGR  WNG+WSD   EW   
Sbjct: 282 SELESMTDKMLVRGHAYSVTGLQDVHYRGKMETLIRVRNPWGRIEWNGAWSDSAREWEEV 341

Query: 756 PGHLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICKVHSD 795
              ++ +L+ H + +G FWM Y DF+  F  ++IC +  D
Sbjct: 342 ASDIQMQLL-HKTEDGEFWMSYQDFLNNFTLLEICNLTPD 380


>gi|38707981 calpain 12 [Homo sapiens]
          Length = 719

 Score =  167 bits (423), Expect = 5e-41
 Identities = 114/335 (34%), Positives = 159/335 (47%), Gaps = 42/335 (12%)

Query: 474 WENIVAFCRENNVSFVDDSFPPGPESVGFP--AGDSVQQRVRQWLRPQEINCSVFRDHRA 531
           +E I A C ++ + F D  FP GP+++G+     DS + +  +W+RP E  C+  +    
Sbjct: 32  YEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEF-CAEPK---- 86

Query: 532 TWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEG---AYQVRLC 588
              +   +  +D+ QG LGNCWFL+A A L   P L+ RV+        G    +  +L 
Sbjct: 87  --FICEDMSRTDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLW 144

Query: 589 KDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGL 648
           + G W  V+VDD LP  E   +     QR + W  L+EKA AKLHGSY  ++ G   E  
Sbjct: 145 QFGRWMDVVVDDRLPVREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAF 204

Query: 649 ATLTGAPCESLALQLSS----TNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVD 704
              TG   E L L+ +S    +  R       L+ A  LS +            G  + +
Sbjct: 205 VDFTGGVGEVLYLRQNSMGLFSALRHALAKESLVGATALSDR------------GEYRTE 252

Query: 705 DSAYESLGLRPRHAYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PG 757
           +      GL   HAYSI     V       RLLRLRNPWG   W G+WSD  P W   P 
Sbjct: 253 E------GLVKGHAYSITGTHKVFLGFTKVRLLRLRNPWGCVEWTGAWSDSCPRWDTLPT 306

Query: 758 HLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICKV 792
             R  L+     +G FWME  DF+ +FD+V IC +
Sbjct: 307 ECRDALLVK-KEDGEFWMELRDFLLHFDTVQICSL 340


>gi|27765074 calpain 3 isoform c [Homo sapiens]
          Length = 729

 Score =  167 bits (422), Expect = 6e-41
 Identities = 113/338 (33%), Positives = 158/338 (46%), Gaps = 31/338 (9%)

Query: 468 GEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFR 527
           G  +  +E +   C E  V +VD  FPP   S+ +     +Q     W RP EI C   R
Sbjct: 55  GVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQF---VWKRPPEI-CENPR 110

Query: 528 DHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQ 584
                  +      +DI QG LG+CWFL+A+A L     L+ RV+       E   G + 
Sbjct: 111 ------FIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFH 164

Query: 585 VRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRA 644
            +  + G W  V++DD LP      +      R + W AL+EKA AKLHGSY AL+ G  
Sbjct: 165 FQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNT 224

Query: 645 IEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVD 704
            E +   TG   E   +       R+ P D   I  K +   E G LMG S     + V 
Sbjct: 225 TEAMEDFTGGVAEFFEI-------RDAPSDMYKIMKKAI---ERGSLMGCSI-DTIIPVQ 273

Query: 705 DSAYESLGLRPRHAYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PG 757
                + GL   HAYS+  + +V    +  +L+RLRNPWG+  WNGSWSD W  W     
Sbjct: 274 YETRMACGLVRGHAYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDK 333

Query: 758 HLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICKVHSD 795
             +  L    + +G FWM Y DF+ +F  ++IC + +D
Sbjct: 334 DEKARLQHQVTEDGEFWMSYEDFIYHFTKLEICNLTAD 371


>gi|4557405 calpain 3 isoform a [Homo sapiens]
          Length = 821

 Score =  157 bits (398), Expect = 4e-38
 Identities = 118/385 (30%), Positives = 164/385 (42%), Gaps = 77/385 (20%)

Query: 468 GEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFR 527
           G  +  +E +   C E  V +VD  FPP   S+ +     +Q     W RP EI C   R
Sbjct: 55  GVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQF---VWKRPPEI-CENPR 110

Query: 528 DHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQ 584
                  +      +DI QG LG+CWFL+A+A L     L+ RV+       E   G + 
Sbjct: 111 ------FIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFH 164

Query: 585 VRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRA 644
            +  + G W  V++DD LP      +      R + W AL+EKA AKLHGSY AL+ G  
Sbjct: 165 FQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNT 224

Query: 645 IEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGG-NM-- 701
            E +   TG   E   +       R+ P D   I  K +   E G LMG S   G NM  
Sbjct: 225 TEAMEDFTGGVAEFFEI-------RDAPSDMYKIMKKAI---ERGSLMGCSIDDGTNMTY 274

Query: 702 ------------------KVDDSAYESLGLRPR--------------------------H 717
                              +D+S  +   L PR                          H
Sbjct: 275 GTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGH 334

Query: 718 AYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSE 770
           AYS+  + +V    +  +L+RLRNPWG+  WNGSWSD W  W       +  L    + +
Sbjct: 335 AYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 394

Query: 771 GVFWMEYGDFVRYFDSVDICKVHSD 795
           G FWM Y DF+ +F  ++IC + +D
Sbjct: 395 GEFWMSYEDFIYHFTKLEICNLTAD 419


>gi|27765072 calpain 3 isoform b [Homo sapiens]
          Length = 815

 Score =  157 bits (398), Expect = 4e-38
 Identities = 118/385 (30%), Positives = 164/385 (42%), Gaps = 77/385 (20%)

Query: 468 GEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFR 527
           G  +  +E +   C E  V +VD  FPP   S+ +     +Q     W RP EI C   R
Sbjct: 55  GVKEKTFEQLHKKCLEKKVLYVDPEFPPDETSLFYSQKFPIQF---VWKRPPEI-CENPR 110

Query: 528 DHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQ 584
                  +      +DI QG LG+CWFL+A+A L     L+ RV+       E   G + 
Sbjct: 111 ------FIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFH 164

Query: 585 VRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRA 644
            +  + G W  V++DD LP      +      R + W AL+EKA AKLHGSY AL+ G  
Sbjct: 165 FQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNT 224

Query: 645 IEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGG-NM-- 701
            E +   TG   E   +       R+ P D   I  K +   E G LMG S   G NM  
Sbjct: 225 TEAMEDFTGGVAEFFEI-------RDAPSDMYKIMKKAI---ERGSLMGCSIDDGTNMTY 274

Query: 702 ------------------KVDDSAYESLGLRPR--------------------------H 717
                              +D+S  +   L PR                          H
Sbjct: 275 GTSPSGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGH 334

Query: 718 AYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSE 770
           AYS+  + +V    +  +L+RLRNPWG+  WNGSWSD W  W       +  L    + +
Sbjct: 335 AYSVTGLDEVPFKGEKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTED 394

Query: 771 GVFWMEYGDFVRYFDSVDICKVHSD 795
           G FWM Y DF+ +F  ++IC + +D
Sbjct: 395 GEFWMSYEDFIYHFTKLEICNLTAD 419


>gi|223468608 calpain 14 [Homo sapiens]
          Length = 684

 Score =  156 bits (394), Expect = 1e-37
 Identities = 112/356 (31%), Positives = 167/356 (46%), Gaps = 39/356 (10%)

Query: 450 PLRRRESMHVEQRRQTDEGEAKALWENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQ 509
           P R R  +     R+    + +  +E ++A C  N   F D SFP    S+G     S+ 
Sbjct: 6   PFRCRWKLAPRYSRRASPQQPQQDFEALLAECLRNGCLFEDTSFPATLSSIG---SGSLL 62

Query: 510 QRVR---QWLRPQEINCSVFRDHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPD 566
           Q++    QW RP E+       H      F   +  D+ QG++G+CWFL+AL  LA   D
Sbjct: 63  QKLPPRLQWKRPPEL-------HSNPQFYFAKAKRLDLCQGIVGDCWFLAALQALALHQD 115

Query: 567 LVERVMVTRSLCAE---GAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQL-WV 622
           ++ RV+       E   G ++      G W  V++DD LP +EAG L+F  +  K L W 
Sbjct: 116 ILSRVVPLNQSFTEKYAGIFRFWFWHYGNWVPVVIDDRLPVNEAGQLVFVSSTYKNLFWG 175

Query: 623 ALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAKM 682
           AL+EKA AKL GSY  LQ+G+  E L   TG    ++ L  +  N          +W  +
Sbjct: 176 ALLEKAYAKLSGSYEDLQSGQVSEALVDFTGGVTMTINLAEAHGN----------LWDIL 225

Query: 683 LSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHAYSILDVRDV----QGTRLLRLRNP 738
           + +     L+G     G   +++      GL   HAY++  +R V    +   L++LRNP
Sbjct: 226 IEATYNRTLIGCQTHSGEKILEN------GLVEGHAYTLTGIRKVTCKHRPEYLVKLRNP 279

Query: 739 WGRFSWNGSWSDEWPHWPGHLRGE--LMPHGSSEGVFWMEYGDFVRYFDSVDICKV 792
           WG+  W G WSD    W      E  L+    ++G FWM   DF  +F  + ICK+
Sbjct: 280 WGKVEWKGDWSDSSSKWELLSPKEKILLLRKDNDGEFWMTLQDFKTHFVLLVICKL 335


>gi|12408656 calpain 1, large subunit [Homo sapiens]
          Length = 714

 Score =  156 bits (394), Expect = 1e-37
 Identities = 107/339 (31%), Positives = 165/339 (48%), Gaps = 31/339 (9%)

Query: 474 WENIVAFCRENNVSFVDDSFPPGPESVGFP--AGDSVQQRVRQWLRPQEINCSVFRDHRA 531
           +E +   C ++   F D++FPP P+S+G+     +S +    +W RP E+  +       
Sbjct: 42  YEQLRVRCLQSGTLFRDEAFPPVPQSLGYKDLGPNSSKTYGIKWKRPTELLSN------- 94

Query: 532 TWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEG---AYQVRLC 588
              +      +DI QG LG+CW L+A+A L     L+ RV+        G    +  +L 
Sbjct: 95  PQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTLLHRVVPHGQSFQNGYAGIFHFQLW 154

Query: 589 KDGTWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGL 648
           + G W  V+VDD+LP  +   +    A+  + W AL+EKA AK++GSY AL  G   EG 
Sbjct: 155 QFGEWVDVVVDDLLPIKDGKLVFVHSAEGNEFWSALLEKAYAKVNGSYEALSGGSTSEGF 214

Query: 649 ATLTGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAY 708
              TG   E   L       R+ P D   ++  +L + E G L+G S    ++ +D  A 
Sbjct: 215 EDFTGGVTEWYEL-------RKAPSD---LYQIILKALERGSLLGCSIDISSV-LDMEAI 263

Query: 709 ESLGLRPRHAYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSD---EWPHWPGHLRG 761
               L   HAYS+   + V    Q   L+R+RNPWG   W G+WSD   EW +   + R 
Sbjct: 264 TFKKLVKGHAYSVTGAKQVNYRGQVVSLIRMRNPWGEVEWTGAWSDSSSEWNNVDPYERD 323

Query: 762 ELMPHGSSEGVFWMEYGDFVRYFDSVDICKVHSDWQEAR 800
           +L      +G FWM + DF+R F  ++IC +  D  ++R
Sbjct: 324 QLRVK-MEDGEFWMSFRDFMREFTRLEICNLTPDALKSR 361


>gi|221554549 calpain 8 [Homo sapiens]
          Length = 703

 Score =  155 bits (392), Expect = 2e-37
 Identities = 111/327 (33%), Positives = 154/327 (47%), Gaps = 31/327 (9%)

Query: 481 CRENNVSFVDDSFPPGPESVGFP--AGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHT 538
           C ++ V F D  FP  P ++G+      S Q +   W RP E+  S          +   
Sbjct: 39  CLDSGVLFKDPEFPACPSALGYKDLGPGSPQTQGIIWKRPTELCPS-------PQFIVGG 91

Query: 539 LRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTT 595
              +DI QG LG+CW L+A+A L    +L+ RV+       E   G +  +  + G W  
Sbjct: 92  ATRTDICQGGLGDCWLLAAIASLTLNEELLYRVVPRDQDFQENYAGIFHFQFWQYGEWVE 151

Query: 596 VLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAP 655
           V++DD LP      L     Q  + W AL+EKA AKL+G Y AL  G  +EG    TG  
Sbjct: 152 VVIDDRLPTKNGQLLFLHSEQGNEFWSALLEKAYAKLNGCYEALAGGSTVEGFEDFTGGI 211

Query: 656 CESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRP 715
            E   L       ++ P +   I  K L    AG L+G S    +   +  A  S  L  
Sbjct: 212 SEFYDL-------KKPPANLYQIIRKALC---AGSLLGCSIDVSS-AAEAEAITSQKLVK 260

Query: 716 RHAYSILDVRDV--QG--TRLLRLRNPWGRFSWNGSWSDEWPHWPGHL---RGELMPHGS 768
            HAYS+  V +V  QG   +L+RLRNPWG   W+G+WSD+ P W  H+   R E +    
Sbjct: 261 SHAYSVTGVEEVNFQGHPEKLIRLRNPWGEVEWSGAWSDDAPEW-NHIDPRRKEELDKKV 319

Query: 769 SEGVFWMEYGDFVRYFDSVDICKVHSD 795
            +G FWM   DFVR F  ++IC +  D
Sbjct: 320 EDGEFWMSLSDFVRQFSRLEICNLSPD 346


>gi|157389005 calpain 2 isoform 1 [Homo sapiens]
          Length = 700

 Score =  151 bits (382), Expect = 3e-36
 Identities = 98/326 (30%), Positives = 144/326 (44%), Gaps = 29/326 (8%)

Query: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVR--QWLRPQEINCSVFRDHRATWSVFHT 538
           C E    F D SFP  P ++GF        + R  +W RP EI             +   
Sbjct: 39  CLEAGTLFQDPSFPAIPSALGFKELGPYSSKTRGIEWKRPTEICAD-------PQFIIGG 91

Query: 539 LRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTT 595
              +DI QG LG+CW L+A+A L    +++ RV+       E   G +  +  + G W  
Sbjct: 92  ATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVE 151

Query: 596 VLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAP 655
           V+VDD LP  +   L    A+  + W AL+EKA AK++G Y AL  G   EG    TG  
Sbjct: 152 VVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGI 211

Query: 656 CESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRP 715
            E   L+    N          ++  +  + + G L+G S        D  A     L  
Sbjct: 212 AEWYELKKPPPN----------LFKIIQKALQKGSLLGCSI-DITSAADSEAITFQKLVK 260

Query: 716 RHAYSILDVRDVQGT----RLLRLRNPWGRFSWNGSWSDEWPHWP--GHLRGELMPHGSS 769
            HAYS+    +V+      +L+R+RNPWG   W G W+D  P W        E +     
Sbjct: 261 GHAYSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHE 320

Query: 770 EGVFWMEYGDFVRYFDSVDICKVHSD 795
           +G FWM + DF+R++  ++IC +  D
Sbjct: 321 DGEFWMSFSDFLRHYSRLEICNLTPD 346


>gi|37577157 calpain 5 [Homo sapiens]
          Length = 640

 Score =  146 bits (369), Expect = 9e-35
 Identities = 105/357 (29%), Positives = 151/357 (42%), Gaps = 45/357 (12%)

Query: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540
           CR   V F D  FP   +S+ +        R   W RP+     +  D R        + 
Sbjct: 20  CRRRKVLFEDPLFPATDDSLYYKGTPGPAVR---WKRPK----GICEDPRL---FVDGIS 69

Query: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVT---------RSLCAEGAYQVRLCKDG 591
             D+ QG +GNCWF++A + LA R  L ++V+           +     G +     + G
Sbjct: 70  SHDLHQGQVGNCWFVAACSSLASRESLWQKVIPDWKEQEWDPEKPNAYAGIFHFHFWRFG 129

Query: 592 TWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATL 651
            W  V++DD LP      +      R + W AL+EKA AKL G Y AL  G   + L   
Sbjct: 130 EWVDVVIDDRLPTVNNQLIYCHSNSRNEFWCALVEKAYAKLAGCYQALDGGNTADALVDF 189

Query: 652 TGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESL 711
           TG   E   + L+  +   +    + ++ +ML     G L+ AS        D  A  + 
Sbjct: 190 TGGVSE--PIDLTEGDFANDETKRNQLFERMLKVHSRGGLISASIKAVT-AADMEARLAC 246

Query: 712 GLRPRHAYSILDVRDV------------QGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHL 759
           GL   HAY++ DVR V            +   ++RLRNPWG   WNG WSD    W    
Sbjct: 247 GLVKGHAYAVTDVRKVRLGHGLLAFFKSEKLDMIRLRNPWGEREWNGPWSDTSEEWQKVS 306

Query: 760 RGELMPHG---SSEGVFWMEYGDFVRYFDSVDICKV--------HSDWQEARVQGCF 805
           + E    G     +G FWM + D  RYF  +  C+V        H  W+EAR+ G +
Sbjct: 307 KSEREKMGVTVQDDGEFWMTFEDVCRYFTDIIKCRVINTSHLSIHKTWEEARLHGAW 363


>gi|5729758 calpain 9 isoform 1 [Homo sapiens]
          Length = 690

 Score =  145 bits (367), Expect = 2e-34
 Identities = 129/460 (28%), Positives = 188/460 (40%), Gaps = 64/460 (13%)

Query: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540
           C +    F D  FP    S+ +     +      W RP EI        +    +     
Sbjct: 36  CLQRGTLFEDADFPASNSSLFYSERPQIPF---VWKRPGEIV-------KNPEFILGGAT 85

Query: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEG---AYQVRLCKDGTWTTVL 597
            +DI QG LG+CW L+A+A L      + RV+        G    +  +  +   W  V+
Sbjct: 86  RTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVV 145

Query: 598 VDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657
           +DD LP      +    A   + W AL+EKA AKL+GSY AL+ G AIE +   TG   E
Sbjct: 146 IDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAE 205

Query: 658 SLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRH 717
           +          +E P +   I  K L   + G L+G          +  A    GL   H
Sbjct: 206 TF-------QTKEAPENFYEILEKAL---KRGSLLGCFI-DTRSAAESEARTPFGLIKGH 254

Query: 718 AYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHW--PGHLRGELMPHGS-SE 770
           AYS+  +  V    Q   L+R+RNPWG+  WNGSWSD  P W   G    + + H +  +
Sbjct: 255 AYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDSSPEWRSVGPAEQKRLCHTALDD 314

Query: 771 GVFWMEYGDFVRYFDSVDICKVHSD---------WQEARVQGCFPSSASA---------- 811
           G FWM + DF  +FD V+IC +  D         W+    QG +   ++A          
Sbjct: 315 GEFWMAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTF 374

Query: 812 ---PVGVTALTV----LERASLEFALFQEGSRRSDAVDSHLLDLCILVFRATFGSGGHLS 864
              P    +LT      E  S   AL Q+  R+     +++L +   ++        HL+
Sbjct: 375 WTNPQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECP-DKDEHLN 433

Query: 865 LGRLLAHSKRAVKKF------VSCDVMLEPGEYAVVCCAF 898
                 H+ RA  K       VS    L PGEY ++   F
Sbjct: 434 KDFFRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTF 473


>gi|47078247 calpain 3 isoform f [Homo sapiens]
          Length = 728

 Score =  144 bits (364), Expect = 3e-34
 Identities = 99/311 (31%), Positives = 137/311 (44%), Gaps = 67/311 (21%)

Query: 542 SDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTTVLV 598
           +DI QG LG+CWFL+A+A L     L+ RV+       E   G +  +  + G W  V++
Sbjct: 32  TDICQGELGDCWFLAAIACLTLNQHLLFRVIPHDQSFIENYAGIFHFQFWRYGEWVDVVI 91

Query: 599 DDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCES 658
           DD LP      +      R + W AL+EKA AKLHGSY AL+ G   E +   TG   E 
Sbjct: 92  DDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLHGSYEALKGGNTTEAMEDFTGGVAEF 151

Query: 659 LALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGG-NM---------------- 701
             +       R+ P D   I  K +   E G LMG S   G NM                
Sbjct: 152 FEI-------RDAPSDMYKIMKKAI---ERGSLMGCSIDDGTNMTYGTSPSGLNMGELIA 201

Query: 702 ----KVDDSAYESLGLRPR--------------------------HAYSILDVRDV---- 727
                +D+S  +   L PR                          HAYS+  + +V    
Sbjct: 202 RMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTGLDEVPFKG 261

Query: 728 QGTRLLRLRNPWGRFSWNGSWSDEWPHW---PGHLRGELMPHGSSEGVFWMEYGDFVRYF 784
           +  +L+RLRNPWG+  WNGSWSD W  W       +  L    + +G FWM Y DF+ +F
Sbjct: 262 EKVKLVRLRNPWGQVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYEDFIYHF 321

Query: 785 DSVDICKVHSD 795
             ++IC + +D
Sbjct: 322 TKLEICNLTAD 332


>gi|225703100 calpain 2 isoform 2 [Homo sapiens]
          Length = 622

 Score =  138 bits (347), Expect = 3e-32
 Identities = 82/263 (31%), Positives = 123/263 (46%), Gaps = 20/263 (7%)

Query: 542 SDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTTVLV 598
           +DI QG LG+CW L+A+A L    +++ RV+       E   G +  +  + G W  V+V
Sbjct: 17  TDICQGALGDCWLLAAIASLTLNEEILARVVPLNQSFQENYAGIFHFQFWQYGEWVEVVV 76

Query: 599 DDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCES 658
           DD LP  +   L    A+  + W AL+EKA AK++G Y AL  G   EG    TG   E 
Sbjct: 77  DDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDFTGGIAEW 136

Query: 659 LALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRHA 718
             L+    N          ++  +  + + G L+G S        D  A     L   HA
Sbjct: 137 YELKKPPPN----------LFKIIQKALQKGSLLGCSI-DITSAADSEAITFQKLVKGHA 185

Query: 719 YSILDVRDVQGT----RLLRLRNPWGRFSWNGSWSDEWPHWP--GHLRGELMPHGSSEGV 772
           YS+    +V+      +L+R+RNPWG   W G W+D  P W        E +     +G 
Sbjct: 186 YSVTGAEEVESNGSLQKLIRIRNPWGEVEWTGRWNDNCPSWNTIDPEERERLTRRHEDGE 245

Query: 773 FWMEYGDFVRYFDSVDICKVHSD 795
           FWM + DF+R++  ++IC +  D
Sbjct: 246 FWMSFSDFLRHYSRLEICNLTPD 268


>gi|7705383 calpain 9 isoform 2 [Homo sapiens]
          Length = 664

 Score =  126 bits (316), Expect = 1e-28
 Identities = 122/457 (26%), Positives = 177/457 (38%), Gaps = 84/457 (18%)

Query: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540
           C +    F D  FP    S+ +     +      W RP EI        +    +     
Sbjct: 36  CLQRGTLFEDADFPASNSSLFYSERPQIPF---VWKRPGEIV-------KNPEFILGGAT 85

Query: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAEG---AYQVRLCKDGTWTTVL 597
            +DI QG LG+CW L+A+A L      + RV+        G    +  +  +   W  V+
Sbjct: 86  RTDICQGELGDCWLLAAIASLTLNQKALARVIPQDQSFGPGYAGIFHFQFWQHSEWLDVV 145

Query: 598 VDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657
           +DD LP      +    A   + W AL+EKA AKL+GSY AL+ G AIE +   TG   E
Sbjct: 146 IDDRLPTFRDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAE 205

Query: 658 SLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRH 717
           +          +E P +   I  K L   + G L+G          +  A    GL   H
Sbjct: 206 TF-------QTKEAPENFYEILEKAL---KRGSLLGCFI-DTRSAAESEARTPFGLIKGH 254

Query: 718 AYSILDVRDV----QGTRLLRLRNPWGRFSWNGSWSDEWPHWPGHLRGELMPHGSSEGVF 773
           AYS+  +  V    Q   L+R+RNPWG+  WNGSWSD                       
Sbjct: 255 AYSVTGIDQVSFRGQRIELIRIRNPWGQVEWNGSWSDR---------------------- 292

Query: 774 WMEYGDFVRYFDSVDICKVHSD---------WQEARVQGCFPSSASA------------- 811
            M + DF  +FD V+IC +  D         W+    QG +   ++A             
Sbjct: 293 -MAFKDFKAHFDKVEICNLTPDALEEDAIHKWEVTVHQGSWVRGSTAGGCRNFLDTFWTN 351

Query: 812 PVGVTALTV----LERASLEFALFQEGSRRSDAVDSHLLDLCILVFRATFGSGGHLSLGR 867
           P    +LT      E  S   AL Q+  R+     +++L +   ++        HL+   
Sbjct: 352 PQIKLSLTEKDEGQEECSFLVALMQKDRRKLKRFGANVLTIGYAIYECP-DKDEHLNKDF 410

Query: 868 LLAHSKRAVKKF------VSCDVMLEPGEYAVVCCAF 898
              H+ RA  K       VS    L PGEY ++   F
Sbjct: 411 FRYHASRARSKTFINLREVSDRFKLPPGEYILIPSTF 447


>gi|89353291 calpain 10 isoform c [Homo sapiens]
          Length = 517

 Score =  123 bits (309), Expect = 8e-28
 Identities = 102/322 (31%), Positives = 149/322 (46%), Gaps = 38/322 (11%)

Query: 488 FVDDSFPPGPESVGFPAGDSVQQRVRQ--WLRPQEINCS--VFRDHRATWSVFHTLRPSD 543
           F D +FP    S+       + Q      W RPQEI  +  +F D           R   
Sbjct: 14  FRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP---------REGQ 64

Query: 544 ILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLC-----AEGAYQVRLCKDGTWTTVLV 598
           + QGLLG+CWFL A A L +   L+++V+             G++  R+ + G W  V  
Sbjct: 65  VKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTT 124

Query: 599 DDMLPCDEAGCLLFSQAQRKQL-WVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657
           DD LPC  AG L FS+ QR+ + W+ L+EK  AK+HGSY  L AG+  + L  LTG   E
Sbjct: 125 DDRLPC-LAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAE 183

Query: 658 SLALQ--LSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRP 715
              L+    S   ++ P   +    + L   +   L+  SC      V      +  L  
Sbjct: 184 RWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLI--SC-----CVLSPRAGARELGE 236

Query: 716 RHAYSILDVRDVQGTR-----LLRLRNPWGRFSWNGSW---SDEWPHWPGHLRGELMPHG 767
            HA+ + D+R++QG       LLR++NPWGR  W G W    + W      +  EL+   
Sbjct: 237 FHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQ- 295

Query: 768 SSEGVFWMEYGDFVRYFDSVDI 789
             EG FW+E  +F+R FD + +
Sbjct: 296 LQEGEFWVEEEEFLREFDELTV 317


>gi|13186302 calpain 10 isoform a [Homo sapiens]
          Length = 672

 Score =  123 bits (309), Expect = 8e-28
 Identities = 102/322 (31%), Positives = 149/322 (46%), Gaps = 38/322 (11%)

Query: 488 FVDDSFPPGPESVGFPAGDSVQQRVRQ--WLRPQEINCS--VFRDHRATWSVFHTLRPSD 543
           F D +FP    S+       + Q      W RPQEI  +  +F D           R   
Sbjct: 14  FRDAAFPAADSSLFCDLSTPLAQFREDITWRRPQEICATPRLFPDDP---------REGQ 64

Query: 544 ILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLC-----AEGAYQVRLCKDGTWTTVLV 598
           + QGLLG+CWFL A A L +   L+++V+             G++  R+ + G W  V  
Sbjct: 65  VKQGLLGDCWFLCACAALQKSRHLLDQVIPPGQPSWADQEYRGSFTCRIWQFGRWVEVTT 124

Query: 599 DDMLPCDEAGCLLFSQAQRKQL-WVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657
           DD LPC  AG L FS+ QR+ + W+ L+EK  AK+HGSY  L AG+  + L  LTG   E
Sbjct: 125 DDRLPC-LAGRLCFSRCQREDVFWLPLLEKVYAKVHGSYEHLWAGQVADALVDLTGGLAE 183

Query: 658 SLALQ--LSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRP 715
              L+    S   ++ P   +    + L   +   L+  SC      V      +  L  
Sbjct: 184 RWNLKGVAGSGGQQDRPGRWEHRTCRQLLHLKDQCLI--SC-----CVLSPRAGARELGE 236

Query: 716 RHAYSILDVRDVQGTR-----LLRLRNPWGRFSWNGSW---SDEWPHWPGHLRGELMPHG 767
            HA+ + D+R++QG       LLR++NPWGR  W G W    + W      +  EL+   
Sbjct: 237 FHAFIVSDLRELQGQAGQCILLLRIQNPWGRRCWQGLWREGGEGWSQVDAAVASELLSQ- 295

Query: 768 SSEGVFWMEYGDFVRYFDSVDI 789
             EG FW+E  +F+R FD + +
Sbjct: 296 LQEGEFWVEEEEFLREFDELTV 317


>gi|41152101 calpain 13 [Homo sapiens]
          Length = 669

 Score =  120 bits (300), Expect = 9e-27
 Identities = 94/321 (29%), Positives = 142/321 (44%), Gaps = 29/321 (9%)

Query: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540
           C     +F D++FP    S+G       +     W RPQ++             +   + 
Sbjct: 28  CLSMGRTFKDETFPAADSSIGQKLLQEKRLSNVIWKRPQDLPGG------PPHFILDDIS 81

Query: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE--GAYQVRLCKDGTWTTVLV 598
             DI QG   +CWFL+AL  L + P   +++++ +S   +  G ++ R  + G W  V++
Sbjct: 82  RFDIQQGGAADCWFLAALGSLTQNPQYRQKILMVQSFSHQYAGIFRFRFWQCGQWVEVVI 141

Query: 599 DDMLPCDEAGCLLFS-QAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCE 657
           DD LP     CL    + Q ++ W  L+EKA AKL GSY  L  G   + L  LTG    
Sbjct: 142 DDRLPVQGDKCLFVRPRHQNQEFWPCLLEKAYAKLLGSYSDLHYGFLEDALVDLTGGVIT 201

Query: 658 SLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESLGLRPRH 717
           ++ L  S       PV  DL+ A   ++K AG L+  +C   +   D +     GL   H
Sbjct: 202 NIHLHSS-------PV--DLVKAVKTATK-AGSLI--TCATPSGPTDTAQAMENGLVSLH 249

Query: 718 AYSILDVRDVQGTR----LLRLRNP--WGRFSWNGSWSDEWPHWPGHL--RGELMPHGSS 769
           AY++     +Q  R    ++ L NP  WG   W G WSD    W      R   +     
Sbjct: 250 AYTVTGAEQIQYRRGWEEIISLWNPWGWGEAEWRGRWSDGSQEWEETCDPRKSQLHKKRE 309

Query: 770 EGVFWMEYGDFVRYFDSVDIC 790
           +G FWM   DF + F ++ IC
Sbjct: 310 DGEFWMSCQDFQQKFIAMFIC 330


>gi|7656959 calpain 7 [Homo sapiens]
          Length = 813

 Score =  110 bits (274), Expect = 9e-24
 Identities = 81/293 (27%), Positives = 141/293 (48%), Gaps = 37/293 (12%)

Query: 514 QWLRPQEINCSVFRDHRATWSVFHTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMV 573
           +W+RP+++  +         ++ +T+    I Q ++ +C F+++LA+ A       + ++
Sbjct: 260 KWVRPEDLTNNP--------TMIYTVSSFSIKQTIVSDCSFVASLAISAAYERRFNKKLI 311

Query: 574 TRSLCAE-----------GAYQVRLCKDGTWTTVLVDDMLPCDEAGCLLFSQAQRK-QLW 621
           T  +  +           G Y V+L  +G    V++DD LP D  G LL S +  K +LW
Sbjct: 312 TGIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGELLCSYSNNKSELW 371

Query: 622 VALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQLSSTNPREEPVDTDLIWAK 681
           V+LIEKA  K+ G Y    +   I+ L  LTG   E +A+   S     +    D  +  
Sbjct: 372 VSLIEKAYMKVMGGYDFPGSNSNID-LHALTGWIPERIAMHSDS-----QTFSKDNSFRM 425

Query: 682 MLSSKEAG-FLMGASCGGGNMKVDDSAYESLGLRPRHAYSILDVRDVQGTRLLRLRNPWG 740
           +      G  L+ AS G     + ++  E  GL P HAY++LD+R+ +G R ++L+NPW 
Sbjct: 426 LYQRFHKGDVLITASTG----MMTEAEGEKWGLVPTHAYAVLDIREFKGLRFIQLKNPWS 481

Query: 741 RFSWNGSWSD-EWPHWPGHLRGEL-----MPHGSSEGVFWMEYGDFVRYFDSV 787
              W G +S+ +  +W   L+  L            G+FW+ + D  +Y+D +
Sbjct: 482 HLRWKGRYSENDVKNWTPELQKYLNFDPRTAQKIDNGIFWISWDDLCQYYDVI 534


>gi|13186316 calpain 6 [Homo sapiens]
          Length = 641

 Score = 95.9 bits (237), Expect = 2e-19
 Identities = 86/335 (25%), Positives = 141/335 (42%), Gaps = 37/335 (11%)

Query: 481 CRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEINCSVFRDHRATWSVFHTLR 540
           C +++  F D +F P  +S+ +   + +      W RPQ+I C           +   + 
Sbjct: 20  CIKDSRLFCDPTFLPENDSLFY---NRLLPGKVVWKRPQDI-CD------DPHLIVGNIS 69

Query: 541 PSDILQGLLGNCWFLSALAVLAERPDLVERVMVT---------RSLCAEGAYQVRLCKDG 591
              + QG LG+   +SA + LA +     + +           ++    G +  R    G
Sbjct: 70  NHQLTQGRLGHKPMVSAFSCLAVQESHWTKTIPNHKEQEWDPQKTEKYAGIFHFRFWHFG 129

Query: 592 TWTTVLVDDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATL 651
            WT V++DD+LP      +        + W AL+EKA AKL G Y AL      + +   
Sbjct: 130 EWTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIVDF 189

Query: 652 TGAPCESLALQLSSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYESL 711
           TG   E++ +Q        E  +   ++ ++  +   G L+  S    N + +       
Sbjct: 190 TGTLAETVDMQKGRYTELVE--EKYKLFGELYKTFTKGGLICCSIESPNQE-EQEVETDW 246

Query: 712 GLRPRHAYSILDVRDVQ-GTRL-----------LRLRNPWGRFSWNGSW---SDEWPHWP 756
           GL   H Y++ D+R ++ G RL           +RLRNP GR  W+G W   S+EW    
Sbjct: 247 GLLKGHTYTMTDIRKIRLGERLVEVFSAEKVYMVRLRNPLGRQEWSGPWSEISEEWQQLT 306

Query: 757 GHLRGELMPHGSSEGVFWMEYGDFVRYFDSVDICK 791
              R  L    S +G FWM   DF R F  +++C+
Sbjct: 307 ASDRKNLGLVMSDDGEFWMSLEDFCRNFHKLNVCR 341


>gi|109150431 ring finger protein 31 [Homo sapiens]
          Length = 1072

 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 43/152 (28%), Positives = 56/152 (36%), Gaps = 35/152 (23%)

Query: 5   GEWSCVRCTFLNPAGQRQCSICEAPR--HKPDL----------------NHILRLSVEEQ 46
           G W+C  CTF N A    CSICE PR    P L                   L  S + Q
Sbjct: 352 GRWACQSCTFENEAAAVLCSICERPRLAQPPSLVVDSRDAGICLQPLQQGDALLASAQSQ 411

Query: 47  KWPCARCTFRNFLGKEACEVCGFTPEPAPGA-AFLPVLNGVLPKPPAILGEPKGSCQEEA 105
            W C  CTF N      C +C  T  P P   A  P  + +   PP            + 
Sbjct: 412 VWYCIHCTFCNSSPGWVCVMCNRTSSPIPAQHAPRPYASSLEKGPP------------KP 459

Query: 106 GPVRTAGLVATEPARGQCEDKDEEEKEEQEEE 137
           GP R      + P    C D +++ +++  EE
Sbjct: 460 GPPRR----LSAPLPSSCGDPEKQRQDKMREE 487



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 38/141 (26%), Positives = 51/141 (36%), Gaps = 35/141 (24%)

Query: 333 PASPSSPDFTTWSCAKCTLRNPTVAPRCSACGCSKLHGFQEHGEPPTHCPDCGADKPSPC 392
           PAS   P    W CA C + N   A  C AC            + P  C   G     P 
Sbjct: 297 PASAHLP----WHCAACAMLNEPWAVLCVAC------------DRPRGCKGLGLGTEGPQ 340

Query: 393 GRSCGRVSSAQKAARVLPERPGQWACPACTLLNALRAKHCAACHTPQL-----LVAQRRG 447
           G        A+          G+WAC +CT  N   A  C+ C  P+L     LV   R 
Sbjct: 341 GTGGLEPDLAR----------GRWACQSCTFENEAAAVLCSICERPRLAQPPSLVVDSRD 390

Query: 448 AA----PLRRRESMHVEQRRQ 464
           A     PL++ +++    + Q
Sbjct: 391 AGICLQPLQQGDALLASAQSQ 411



 Score = 38.5 bits (88), Expect = 0.035
 Identities = 19/48 (39%), Positives = 22/48 (45%), Gaps = 3/48 (6%)

Query: 133 EQEEEEGAAEP---RGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRI 177
           E  +  G  EP   RG WAC  CT  N   A  CS+C  PR    P +
Sbjct: 337 EGPQGTGGLEPDLARGRWACQSCTFENEAAAVLCSICERPRLAQPPSL 384



 Score = 38.1 bits (87), Expect = 0.045
 Identities = 19/70 (27%), Positives = 23/70 (32%), Gaps = 9/70 (12%)

Query: 7   WSCVRCTFLNPAGQRQCSICEAPR---------HKPDLNHILRLSVEEQKWPCARCTFRN 57
           W C  C  LN      C  C+ PR           P     L   +   +W C  CTF N
Sbjct: 304 WHCAACAMLNEPWAVLCVACDRPRGCKGLGLGTEGPQGTGGLEPDLARGRWACQSCTFEN 363

Query: 58  FLGKEACEVC 67
                 C +C
Sbjct: 364 EAAAVLCSIC 373



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 25/95 (26%), Positives = 34/95 (35%), Gaps = 17/95 (17%)

Query: 344 WSCAKCTLRNPTVAPRCSACGCSKLHGFQEHGEPPTHCPDCGADKPSPCGRSCGR-VSSA 402
           W+C  CT  N   A  CS C   +L       +PP+   D          R  G  +   
Sbjct: 354 WACQSCTFENEAAAVLCSICERPRL------AQPPSLVVD---------SRDAGICLQPL 398

Query: 403 QKAARVLPERPGQ-WACPACTLLNALRAKHCAACH 436
           Q+   +L     Q W C  CT  N+     C  C+
Sbjct: 399 QQGDALLASAQSQVWYCIHCTFCNSSPGWVCVMCN 433


>gi|150418007 RAN binding protein 2 [Homo sapiens]
          Length = 3224

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 105/528 (19%), Positives = 162/528 (30%), Gaps = 109/528 (20%)

Query: 7    WSCVRCTFLNPAGQRQCSICE-------------------APRHKPDL---NHILRLSVE 44
            W C  C+  N +  ++C  C+                    P+  P+       L    +
Sbjct: 1356 WHCNSCSLKNASTAKKCVSCQNLNPSNKELVGPPLAETVFTPKTSPENVQDRFALVTPKK 1415

Query: 45   EQKWPCARCTFRNFLGKEACEVCGFTPEP-APGAAFLPVLN-----GVLPKP-------- 90
            E  W C+ C  RN      C  C  T      G++F+   +     G LPKP        
Sbjct: 1416 EGHWDCSICLVRNEPTVSRCIACQNTKSANKSGSSFVHQASFKFGQGDLPKPINSDFRSV 1475

Query: 91   ----------PAILGEPKGS---CQEEAGPVRTAGLVATE---PARGQCEDKDEEEKEEQ 134
                       A L + +GS   C     P R   L AT    PA  +    +  +  + 
Sbjct: 1476 FSTKEGQWDCSACLVQNEGSSTKCAACQNP-RKQSLPATSIPTPASFKFGTSETSKTLKS 1534

Query: 135  EEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVVPEVVAPAGFH 194
              E+  A+  G W C  C + N   A+ C  C  P +      P  +  VP   APA F 
Sbjct: 1535 GFEDMFAKKEGQWDCSSCLVRNEANATRCVACQNPDK------PSPSTSVP---APASFK 1585

Query: 195  V----VPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQNNPVPRSRRE 250
                    AP  G  G   +              E       +      QN   P  + +
Sbjct: 1586 FGTSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIA-----CQN---PGKQNQ 1637

Query: 251  VPPQLQPPVPEAAQPSPSAGCRG---APQGSGWAGASRLAELLSGKRLSVLEEEATEGGT 307
                +  P       +P +G  G     +G        +    S  +    +    +  T
Sbjct: 1638 TTSAVSTPASSETSKAPKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQT 1697

Query: 308  SRVEAGSSTSGSDIIDLAGDTVRYTPASPSSPDFTTWSCAKCTLRNPTVAPRCSACGCSK 367
            +   +  ++S +     +G    +T           W C+ C +RN   A +C AC    
Sbjct: 1698 TSAVSTPASSETSKAPKSGFEGMFTKKEGQ------WDCSVCLVRNEASATKCIAC---- 1747

Query: 368  LHGFQEHGEPPTHCPDCGADKPSPCGRSCGRVSSAQKAA-RVLPERPGQWACPACTLLNA 426
                         CP       +    +   +S A K+    +  R GQW C  C + N 
Sbjct: 1748 ------------QCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQWDCSVCCVQNE 1795

Query: 427  LRAKHCAAC------HTPQLLVAQRRGAAPLRRRESMHVEQRRQTDEG 468
              +  C AC      H P   +A+   A  L     +H     Q   G
Sbjct: 1796 SSSLKCVACDASKPTHKP---IAEAPSAFTLGSEMKLHDSSGSQVGTG 1840



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 45/218 (20%), Positives = 68/218 (31%), Gaps = 60/218 (27%)

Query: 5    GEWSCVRCTFLNPAGQRQCSICEAPRHK-----------------PDLNHILRLSVE--- 44
            G+W C  C   N     +C+ C+ PR +                  + +  L+   E   
Sbjct: 1481 GQWDCSACLVQNEGSSTKCAACQNPRKQSLPATSIPTPASFKFGTSETSKTLKSGFEDMF 1540

Query: 45   ---EQKWPCARCTFRNFLGKEACEVCGFTPEPAPGAA--------FLPVLNGVLPKP--P 91
               E +W C+ C  RN      C  C    +P+P  +        F        PK    
Sbjct: 1541 AKKEGQWDCSSCLVRNEANATRCVACQNPDKPSPSTSVPAPASFKFGTSETSKAPKSGFE 1600

Query: 92   AILGEPKG-------------------SCQEEAGPVRTAGLVATEPARGQCEDKDEEEKE 132
             +  + +G                   +CQ      +T   V+T PA        E  K 
Sbjct: 1601 GMFTKKEGQWDCSVCLVRNEASATKCIACQNPGKQNQTTSAVST-PA------SSETSKA 1653

Query: 133  EQEEEEGA-AEPRGGWACPRCTLHNTPVASSCSVCGGP 169
             +   EG   +  G W C  C + N   A+ C  C  P
Sbjct: 1654 PKSGFEGMFTKKEGQWDCSVCLVRNEASATKCIACQNP 1691



 Score = 31.6 bits (70), Expect = 4.3
 Identities = 17/79 (21%), Positives = 29/79 (36%), Gaps = 16/79 (20%)

Query: 5    GEWSCVRCTFLNPAGQRQCSICEAPRHK--------PDLNHILR--------LSVEEQKW 48
            G+W C  C   N A   +C  C+ P  +        P  + I +        + + + +W
Sbjct: 1726 GQWDCSVCLVRNEASATKCIACQCPSKQNQTTAISTPASSEISKAPKSGFEGMFIRKGQW 1785

Query: 49   PCARCTFRNFLGKEACEVC 67
             C+ C  +N      C  C
Sbjct: 1786 DCSVCCVQNESSSLKCVAC 1804



 Score = 30.4 bits (67), Expect = 9.5
 Identities = 12/31 (38%), Positives = 16/31 (51%), Gaps = 2/31 (6%)

Query: 5    GEWSCVRCTFLNPAGQRQCSICEA--PRHKP 33
            G+W C  C   N +   +C  C+A  P HKP
Sbjct: 1783 GQWDCSVCCVQNESSSLKCVACDASKPTHKP 1813


>gi|153792074 proline rich 12 [Homo sapiens]
          Length = 2036

 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 78/291 (26%), Positives = 107/291 (36%), Gaps = 67/291 (23%)

Query: 68   GFTPEPAPGAAFLPVL--NGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPARG---- 121
            G TP  +P  +  P +   G+ P+PPA    P       +G     G +    + G    
Sbjct: 1302 GLTPPLSPPKSVPPSVPARGLQPQPPATPAVPH---PPPSGAFGLGGALEAAESEGLGLG 1358

Query: 122  ---QCEDKDEEEKEEQE--------EEEGAAEPRG---GWACPRCTLHNTPVASSCSVCG 167
                C+  DEE K   E        EE+  A+ R      +     L + P+A       
Sbjct: 1359 CPSPCKRLDEELKRNLETLPSFSSDEEDSVAKNRDLQESISSAISALDDPPLA------- 1411

Query: 168  GPRRLSLPRIPPEALVVPEVVAPAGFHVVPAAPP-PGLPGEGAEANPPATSQGPAAEPEP 226
            GP+  S P  PP        +APA    VP  PP PGLP     AN   T + P  E +P
Sbjct: 1412 GPKDTSTPDGPP--------LAPAA--AVPGPPPLPGLPS----ANSNGTPEPPLLEEKP 1457

Query: 227  PRVPPFSPFSSTLQNNPVPRSRREV---------------PPQLQPPVPEA-----AQPS 266
            P  PP +P        P P  +  +               PP L PP P A       P 
Sbjct: 1458 PPTPPPAPTPQPQPPPPPPPPQPALPSPPPLVAPTPSSPPPPPLPPPPPPAMPSPPPPPP 1517

Query: 267  PSAGCRGAPQGSGWAGASRLAELLSGKRLSVLEEEATEG--GTSRVEAGSS 315
            P+A    AP     A +    EL   + L + +++ T    G +  EAG S
Sbjct: 1518 PAAAPLAAPPEEPAAPSPEDPELPDTRPLHLAKKQETAAVCGETDEEAGES 1568



 Score = 34.7 bits (78), Expect = 0.50
 Identities = 29/103 (28%), Positives = 36/103 (34%), Gaps = 1/103 (0%)

Query: 220  PAAEPEPPRVPPFSPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSG 279
            P   P+ PR     P  +     P PR R  + P   P     A  S        P+G G
Sbjct: 1145 PNPGPDGPRRRGRKPTKAKRDGPPRPRGRPRIRPLEVPTTAGPASASTPTDGAKKPRGRG 1204

Query: 280  WAGASRLAELLSGKRLSVLEEEATEGGTSRVEAGSSTSGSDII 322
              G  R AE   G RL  L+    +    +   G  TS  D I
Sbjct: 1205 -RGRGRKAEEAGGTRLEPLKPLKIKLSVPKAGEGLGTSSGDAI 1246



 Score = 33.9 bits (76), Expect = 0.86
 Identities = 37/117 (31%), Positives = 45/117 (38%), Gaps = 23/117 (19%)

Query: 167 GGPRR-LSLPRIPPEALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPE 225
           GGP   L LP  PP+ L  P V++ A       +P P     G     PAT  G    P 
Sbjct: 786 GGPDLPLVLPPPPPQLL--PSVLSHA------PSPSPSASKVGVHLLEPATRDGAPQPPP 837

Query: 226 PPRVPPFSPFSSTLQNN----------PVPRSRREV---PPQLQPPVPEAAQPSPSA 269
           PP  PP  P    L+ +          P PR R E    PP     +  A +P P A
Sbjct: 838 PPPPPP-PPMPLQLEAHLRSHGLEPAAPSPRLRPEESLDPPGAMQELLGALEPLPPA 893


>gi|56549694 enabled homolog isoform a [Homo sapiens]
          Length = 591

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 56/202 (27%), Positives = 88/202 (43%), Gaps = 20/202 (9%)

Query: 124 EDKDEEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPEALV 183
           ++++ +E+ E+E+ E   E R   A    ++  TP+ S      G    S P +   A  
Sbjct: 243 QERERQEQLEREQLEWERERRISSAAAPASVE-TPLNSVL----GDSSASEPGLQA-ASQ 296

Query: 184 VPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSST--LQN 241
             E  +  G  + P APPP  P       PP  +Q   A P PP  PP  P  ST     
Sbjct: 297 PAETPSQQGIVLGPLAPPPPPP------LPPGPAQASVALPPPPGPPPPPPLPSTGPPPP 350

Query: 242 NPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELLSG---KRLSVL 298
            P P    +VPP   PP P  A P P++G   A         + LA  ++G   +++S +
Sbjct: 351 PPPPPLPNQVPP---PPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRM 407

Query: 299 EEEATEGGTSRVEAGSSTSGSD 320
           E+ +   G + +   S++S +D
Sbjct: 408 EDTSFPSGGNAIGVNSASSKTD 429


>gi|39930375 enabled homolog isoform b [Homo sapiens]
          Length = 570

 Score = 54.3 bits (129), Expect = 6e-07
 Identities = 56/202 (27%), Positives = 88/202 (43%), Gaps = 20/202 (9%)

Query: 124 EDKDEEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPEALV 183
           ++++ +E+ E+E+ E   E R   A    ++  TP+ S      G    S P +   A  
Sbjct: 243 QERERQEQLEREQLEWERERRISSAAAPASVE-TPLNSVL----GDSSASEPGLQA-ASQ 296

Query: 184 VPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSST--LQN 241
             E  +  G  + P APPP  P       PP  +Q   A P PP  PP  P  ST     
Sbjct: 297 PAETPSQQGIVLGPLAPPPPPP------LPPGPAQASVALPPPPGPPPPPPLPSTGPPPP 350

Query: 242 NPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELLSG---KRLSVL 298
            P P    +VPP   PP P  A P P++G   A         + LA  ++G   +++S +
Sbjct: 351 PPPPPLPNQVPP---PPPPPPAPPLPASGFFLASMSEDNRPLTGLAAAIAGAKLRKVSRM 407

Query: 299 EEEATEGGTSRVEAGSSTSGSD 320
           E+ +   G + +   S++S +D
Sbjct: 408 EDTSFPSGGNAIGVNSASSKTD 429


>gi|11386183 WAS protein family, member 2 [Homo sapiens]
          Length = 498

 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 40/127 (31%), Positives = 45/127 (35%), Gaps = 19/127 (14%)

Query: 168 GPRRLSL--PRIPPEALVVPEVVAPA-GFHVVPAAPPPGLPGEGAEANPPATSQGPAAEP 224
           GP+R S+  P  PP A  +     P  GF   PA PPP  P  G    PP    G    P
Sbjct: 288 GPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPGTP 347

Query: 225 EPPRVPPFSPFSS----------------TLQNNPVPRSRREVPPQLQPPVPEAAQPSPS 268
            PP  P F P                   TL   P+ +     PP   PP P    P P 
Sbjct: 348 PPPSPPSFPPHPDFAAPPPPPPPPAADYPTLPPPPLSQPTGGAPPPPPPPPPPGPPPPPF 407

Query: 269 AGCRGAP 275
            G  G P
Sbjct: 408 TGADGQP 414



 Score = 33.9 bits (76), Expect = 0.86
 Identities = 25/88 (28%), Positives = 29/88 (32%), Gaps = 5/88 (5%)

Query: 187 VVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPR-----VPPFSPFSSTLQN 241
           +  P    VV  + PP  P  G+   P      P A P PP       PP  P       
Sbjct: 286 LAGPKRSSVVSPSHPPPAPPLGSPPGPKPGFAPPPAPPPPPPPMIGIPPPPPPVGFGSPG 345

Query: 242 NPVPRSRREVPPQLQPPVPEAAQPSPSA 269
            P P S    PP      P    P P+A
Sbjct: 346 TPPPPSPPSFPPHPDFAAPPPPPPPPAA 373


>gi|122937496 WAS/WASL interacting protein family, member 3 [Homo
           sapiens]
          Length = 483

 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 39/114 (34%), Positives = 55/114 (48%), Gaps = 15/114 (13%)

Query: 175 PRIPPEALVVPEVVAP--AGFHV------VPAAPPPGLPGEGAE-ANPPATSQGPAAEPE 225
           P +PP +++  + V P  A  H+      +P  PP G PG  AE A+P   +Q P A P 
Sbjct: 235 PPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPCGYPGLKAEPASPAQDAQEPPAPPP 294

Query: 226 PPRVPPFSPFS--STLQNNPVP--RSRREVPPQLQPPVPEAAQPSPSAGCRGAP 275
           P  +PP++  S  ++L   P+P   S  E PP L P  P    P   AG +  P
Sbjct: 295 P--LPPYASCSPRASLPAPPLPGVNSSSETPPPLPPKSPSFQAPPQKAGAQALP 346



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 61/232 (26%), Positives = 84/232 (36%), Gaps = 45/232 (19%)

Query: 71  PEPAPGAAFLPVLNGVLPKPPAI-----------LGEPKGSCQEEAGPVRTAGLVATEPA 119
           P P P     P L    P PP+              +PKG     A   +   L      
Sbjct: 6   PPPPPLPPPPPPLGAPPPPPPSAPPVSTDTSSLRRADPKGRSALLADIQQGTRLRKVTQI 65

Query: 120 RGQCEDKDEEEKEEQEEEEGAAEPRGGWACPRCTLHNT-----PV---ASSCSVCGGPR- 170
             +   + E  K   +E  G+A  RG    P  TL +      PV   A    V GG   
Sbjct: 66  NDRSAPQIESSKGTNKEGGGSANTRGASTPP--TLGDLFAGGFPVLRPAGQRDVAGGKTG 123

Query: 171 -----RLSLPRIPPEALVVPEVVAPAGFHV---------VPAAPP-PGLPGEGAEANPPA 215
                R   PR+P + +  P ++ PA   +            APP P +P       PP 
Sbjct: 124 QGPGSRAPSPRLPNKTISGP-LIPPASPRLGNTSEAHGAARTAPPRPNVPA------PPP 176

Query: 216 TSQGPAAEPEPPRVPPFSPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSP 267
            +  P   P PP +P  SP  + L + P P ++  + P + PPVP A  P P
Sbjct: 177 PTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNL-PVVAPPVPCAPPPPP 227



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 32/130 (24%), Positives = 48/130 (36%), Gaps = 9/130 (6%)

Query: 175 PRIPPEALVVPEVVAPA----GFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVP 230
           P +PP A   P    PA    G +     PPP LP +      P    G  A P PP  P
Sbjct: 294 PPLPPYASCSPRASLPAPPLPGVNSSSETPPP-LPPKSPSFQAPPQKAGAQALPAPPAPP 352

Query: 231 PFSPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELL 290
              PF    ++        ++ P   PP P A  P+     + + Q + W    +    L
Sbjct: 353 GSQPFLQKKRHGRPGAGGGKLNP---PPAPPARSPTTELSSK-SQQATAWTPTQQPGGQL 408

Query: 291 SGKRLSVLEE 300
               L ++++
Sbjct: 409 RNGSLHIIDD 418



 Score = 37.4 bits (85), Expect = 0.078
 Identities = 28/101 (27%), Positives = 37/101 (36%), Gaps = 5/101 (4%)

Query: 175 PRIPPEALVVPEVVAPAGFHVVPAAPPPG--LPGEGAEANPPATSQGPAAEPEPPRVPPF 232
           P  PP    +P  +  +     P   PPG    G      PP     P   P PP  PP 
Sbjct: 177 PTPPPPPPPLPPPLPSSSPIKTPLVSPPGPLTKGNLPVVAPPVPCAPPPPPPPPPPTPPP 236

Query: 233 SPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRG 273
            P +S L +  V   + ++ P   PP+P      P  G  G
Sbjct: 237 LPPASVLSDKAV---KPQLAPLHLPPIPPPLPLLPPCGYPG 274



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 26/103 (25%), Positives = 34/103 (33%), Gaps = 1/103 (0%)

Query: 173 SLPRIPPEALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPF 232
           +LP + P     P    P      P  PP  +  + A     A    P   P  P +PP 
Sbjct: 211 NLPVVAPPVPCAPPPPPPPPPPTPPPLPPASVLSDKAVKPQLAPLHLPPIPPPLPLLPPC 270

Query: 233 SPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAP 275
             +         P    + PP   PP+P  A  SP A     P
Sbjct: 271 G-YPGLKAEPASPAQDAQEPPAPPPPLPPYASCSPRASLPAPP 312



 Score = 30.8 bits (68), Expect = 7.3
 Identities = 26/86 (30%), Positives = 31/86 (36%), Gaps = 3/86 (3%)

Query: 187 VVAPAGFHVVPAAPPPGLPGEGAEAN--PPATSQGPAAEPEPPRVPPFSPFSSTLQNNPV 244
           V+ PAG   V        PG  A +   P  T  GP   P  PR+   S      +  P 
Sbjct: 108 VLRPAGQRDVAGGKTGQGPGSRAPSPRLPNKTISGPLIPPASPRLGNTSEAHGAARTAPP 167

Query: 245 -PRSRREVPPQLQPPVPEAAQPSPSA 269
            P      PP   PP P    P PS+
Sbjct: 168 RPNVPAPPPPTPPPPPPPLPPPLPSS 193


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 56/210 (26%), Positives = 68/210 (32%), Gaps = 23/210 (10%)

Query: 68   GFTPEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAG-PVRTAGLVATEPARGQCEDK 126
            G    P  GA   P      PK       PKG+    A  P    G +AT   +G     
Sbjct: 1162 GLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGA---- 1217

Query: 127  DEEEKEEQEEEEGAAEPRGGWACPRCT-LHNTPVASSCSVCGGPRRLSLPRIPPEALVVP 185
                            P+GG A P       TP A+  S  GGP   + P  PP+    P
Sbjct: 1218 ------PTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGP---ATP--PPKGAPTP 1266

Query: 186  EVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQNNPVP 245
                P       A PP       A   PP+   GPA  P  P+  P  P ++     P P
Sbjct: 1267 PAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATSP--PKGAPTPPAATP----PSP 1320

Query: 246  RSRREVPPQLQPPVPEAAQPSPSAGCRGAP 275
            +     PP    P P A  P    G    P
Sbjct: 1321 KGSPGTPPPKGAPTPPAVTPPSPKGTPTLP 1350



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 56/214 (26%), Positives = 69/214 (32%), Gaps = 14/214 (6%)

Query: 71   PEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPARGQCEDKDEEE 130
            P P    A  P+  G    P A L  PKG     +         AT P+          +
Sbjct: 1041 PSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPK 1100

Query: 131  KEEQEEEEGAAEPRGGWAC-PRCTLHNTPVASSCSVCGG---PRRLSLPRIPPEALVVPE 186
                        P+GG A  P      TP A+  S  GG   P     P  P      P+
Sbjct: 1101 GAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPK 1160

Query: 187  ----VVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPR-----VPPFSPFSS 237
                   P G    PAA PP   G  A  +P      PAA P  P+       P    ++
Sbjct: 1161 GGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT 1220

Query: 238  TLQNNPVPRSRREVP-PQLQPPVPEAAQPSPSAG 270
                 P P+     P P+  P  P A  PSP  G
Sbjct: 1221 PAATPPSPKGGLATPSPKGAPTTPAATPPSPKGG 1254



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 60/226 (26%), Positives = 71/226 (31%), Gaps = 24/226 (10%)

Query: 68   GFTPEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAG-PVRTAGLVATEPARGQCEDK 126
            G    P  GA   P      PK       PKG+    A  P    G +AT P +G     
Sbjct: 1116 GLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGA---- 1171

Query: 127  DEEEKEEQEEEEGAAEPRGGWACPRCT-LHNTPVASSCSVCGG---PRRLSLPRIPPEAL 182
                            P+GG A P       TP A+  S  GG   P     P  P    
Sbjct: 1172 ------PTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATP 1225

Query: 183  VVPE----VVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPR----VPPFSP 234
              P+      +P G    PAA PP   G  A   P      PAA P   +     PP   
Sbjct: 1226 PSPKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKG 1285

Query: 235  FSS-TLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSG 279
              +  +   P P+      P    P P AA P    G  G P   G
Sbjct: 1286 APNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKG 1331



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 62/224 (27%), Positives = 79/224 (35%), Gaps = 38/224 (16%)

Query: 70   TPEPAPGAAFLPVLNGVLPKPPAILG-EPKGSCQEEAGPVRTAGLVATEPA--RGQCEDK 126
            TP    G    P   G  P PPA+    PKGS      P   +   A  P   +G     
Sbjct: 992  TPPSPKGGPATPSPKGA-PTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAAT 1050

Query: 127  DEEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVVPE 186
               +            P+GG A P      TP A++               PP     P 
Sbjct: 1051 PLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAAT---------------PPSPKGGPA 1095

Query: 187  VVAPAGFHVVPAAPPP----GL---PGEGAEANPPATSQGP--AAEPEPPRVPPFSPFSS 237
              +P G  + PAA PP    GL   P +GA   P AT   P       PP+  P +P ++
Sbjct: 1096 TPSPKGAPMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAAT 1155

Query: 238  TLQNNPVPRSRREV-PPQLQPPVPEAAQPSPSAGC-----RGAP 275
                 P P+      PP+  P  P A  PSP  G      +GAP
Sbjct: 1156 P----PSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAP 1195



 Score = 47.4 bits (111), Expect = 7e-05
 Identities = 61/212 (28%), Positives = 73/212 (34%), Gaps = 29/212 (13%)

Query: 70   TPEPAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAG-PVRTAGLVATEPARGQCEDKDE 128
            TP P  GA   P      PK       PKG+    A  P    G +AT   +G       
Sbjct: 1188 TPSPK-GAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGA------ 1240

Query: 129  EEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSC-SVCGG---PRRLSLPR----IPPE 180
                          P+GG A P      TP A++  S+ GG   P     P      PP 
Sbjct: 1241 ----PTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPS 1296

Query: 181  ALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQ 240
                P    P G    PAA PP    +G+   PP     P   P PP V P SP  +   
Sbjct: 1297 PKGGPATSPPKGAPTPPAATPPS--PKGSPGTPP-----PKGAPTPPAVTPPSPKGTPTL 1349

Query: 241  NNPVPRSR--REVPPQLQPPVPEAAQPSPSAG 270
                P S+     P   + P P AA PS   G
Sbjct: 1350 PATTPSSKGGPTTPSSKEGPTPPAATPSHKGG 1381



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 60/222 (27%), Positives = 74/222 (33%), Gaps = 42/222 (18%)

Query: 73   PAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAG-PVRTAGLVATEPARGQCEDKDEEEK 131
            P P AA  P   G L  PP      KG+    A  P    G +AT P +G          
Sbjct: 1103 PMPPAATPPSPKGGLATPPH-----KGAPTTPAATPPSPKGGLATPPPKGA--------- 1148

Query: 132  EEQEEEEGAAEPRGGWACPRCT-LHNTPVASSCSVCGG---PRRLSLPRIPPEALVVPE- 186
                       P+GG A P       TP A+  S  GG   P     P  P      P+ 
Sbjct: 1149 -PTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKG 1207

Query: 187  ---VVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQNNP 243
                 +P G    PAA PP   G  A  +P      PAA P  P+  P +P         
Sbjct: 1208 GLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGPATP--------- 1258

Query: 244  VPRSRREVPPQLQPP--------VPEAAQPSPSAGCRGAPQG 277
             P      PP   PP         P    P+P+     +P+G
Sbjct: 1259 -PPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKG 1299



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 43/146 (29%), Positives = 53/146 (36%), Gaps = 28/146 (19%)

Query: 143  PRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVVPEVVAPAGFHVVPAAPPP 202
            P+GG A P      TP A++               PP     P   +P G    PAA PP
Sbjct: 950  PKGGPATPSPKWAPTPPAAT---------------PPSPKGGPATPSPKGAPTPPAATPP 994

Query: 203  GLPGEGAEANPPATSQGPAAEPEPPR-VPPFSPFSSTLQNNP--VPRSRREVP-----PQ 254
               G  A  +P      PA  P  P+  P  +PF       P   P S +  P     P+
Sbjct: 995  SPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPK 1054

Query: 255  LQPPVPEAAQPSPSAG-----CRGAP 275
              P  P A  PSP  G      +GAP
Sbjct: 1055 GAPTTPAATLPSPKGGPATPSLKGAP 1080



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 31/104 (29%), Positives = 43/104 (41%), Gaps = 4/104 (3%)

Query: 176  RIPPEALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPF 235
            R  P    +P   +P G    PAA PP   G  A  +P      PAA P  P+  P +P 
Sbjct: 922  RATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATP- 980

Query: 236  SSTLQNNPVPRSRREVPPQLQPPVPE-AAQPSPSAGCRGAPQGS 278
              + +  P P +     P+  P  P     P+P A    +P+GS
Sbjct: 981  --SPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGS 1022



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 46/153 (30%), Positives = 55/153 (35%), Gaps = 24/153 (15%)

Query: 143  PRGGWACPRCTLHNTPVASSC-SVCGGPRRLSLPRIPPEALVVPE--------VVAPAGF 193
            P+GG A P      TP A++  S  GGP   S    P    V P            P G 
Sbjct: 973  PKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGA 1032

Query: 194  HVVPAAPPPGLPG--------EGAEANPPATSQGPAAEPEPPRVP--PFSPFSSTLQNNP 243
               PAA PP   G        +GA   P AT   P   P  P +   P  P ++     P
Sbjct: 1033 STPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATP----P 1088

Query: 244  VPRSRREVPPQLQPPVPEAA-QPSPSAGCRGAP 275
             P+     P     P+P AA  PSP  G    P
Sbjct: 1089 SPKGGPATPSPKGAPMPPAATPPSPKGGLATPP 1121



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 68/274 (24%), Positives = 95/274 (34%), Gaps = 23/274 (8%)

Query: 73   PAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPARGQCEDKDEEEKE 132
            P P AA  P L G L  PP   G P  +      P    G  AT P +G           
Sbjct: 1264 PTPPAATPPSLKGGLATPPH-KGAPNPAVVTPPSP---KGGPATSPPKG-APTPPAATPP 1318

Query: 133  EQEEEEGAAEPRGGWACPRCTLHN---TPV--ASSCSVCGGPRRLSLPRIPPEALVVPEV 187
              +   G   P+G    P  T  +   TP   A++ S  GGP   S    P      P  
Sbjct: 1319 SPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSKGGPTTPSSKEGPTPPAATPSH 1378

Query: 188  VAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQNNPVPRS 247
                     PA  PP      A  +P      PA  P  P+  P +P +      P   S
Sbjct: 1379 KGG------PAMTPPSPKRGPAIPSPKGDPTSPAVIPLSPKKAPATPVTREGAATP---S 1429

Query: 248  RREVPPQLQPPVPEAAQPSPSAGCRGAPQGSGWAGASRLAELL--SGKRLSVLEEEATEG 305
            + ++ P    PV     P+ SA  +G P      G   L  +   S K     ++ AT  
Sbjct: 1430 KGDLTPPAVTPVSLKKAPATSAP-KGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSS 1488

Query: 306  GTSRVEAGSSTSGSDIID-LAGDTVRYTPASPSS 338
               +  A  +  G+  +  +   + +  PA+PSS
Sbjct: 1489 SPKKAPATPAPMGAPTLPAVIPSSPKEVPATPSS 1522



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 56/220 (25%), Positives = 66/220 (30%), Gaps = 17/220 (7%)

Query: 73   PAP-GAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPARGQCEDKDEEEK 131
            PAP G    P   G    P A    PKG     +         AT P+          + 
Sbjct: 925  PAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKG 984

Query: 132  EEQEEEEGAAEPRGGWACPRCTLHNTPVA-SSCSVCGGPRRLSLPR--------IPPEAL 182
                       P+GG A P      TP A +  S  G P     P+         PP   
Sbjct: 985  APTPPAATPPSPKGGPATPSPKGAPTPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPK 1044

Query: 183  VVPEVVA-PAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSS---- 237
              P     P G    PAA  P   G  A  +       PAA P  P+  P +P       
Sbjct: 1045 GSPAATPLPKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPM 1104

Query: 238  -TLQNNPVPRSRREVPPQL-QPPVPEAAQPSPSAGCRGAP 275
                  P P+     PP    P  P A  PSP  G    P
Sbjct: 1105 PPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGLATPP 1144



 Score = 38.5 bits (88), Expect = 0.035
 Identities = 48/188 (25%), Positives = 72/188 (38%), Gaps = 34/188 (18%)

Query: 91   PAILGEPKGSCQEEAGPVRTAGLVATEPARGQCEDKDEEEKEEQEEEEGAAEPRGGWACP 150
            P I  +P        GP+ T       P +       ++  +  + ++ +  P+G  A P
Sbjct: 1714 PPICPDPSAK-NGSKGPLSTVAPAPLLPVQ-------KDSSKTAKGKDASHSPKGPLAPP 1765

Query: 151  RCTLHNTPVASSC--SVCGGPRRLSLPRIPPEALVVPEVVAPAGFHVVPAAPP-----PG 203
                 +TP+ ++    V   P   S+   P   + +P   +P     VP  PP     P 
Sbjct: 1766 ESKA-STPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAPSP-----VPTLPPKQQFLPS 1819

Query: 204  LPGEGAEANPPATSQGPAAEPEP-PRVPPFS-----PFSSTLQNNPVPRSRREVPPQLQP 257
             PG   E+  P+    PA E E  P +PP       PF S L N P P+S       +  
Sbjct: 1820 SPGLVLES--PSKPLAPADEDELLPLIPPEPISGGVPFQSVLVNMPTPKS-----AGIPV 1872

Query: 258  PVPEAAQP 265
            P P A QP
Sbjct: 1873 PTPSAKQP 1880



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 31/102 (30%), Positives = 39/102 (38%), Gaps = 12/102 (11%)

Query: 178  PPEALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSS 237
            P +A   P   AP G   +PA+P P    +GA   P AT   P   P  P  P ++P + 
Sbjct: 918  PKKARATP---APKG---IPASPSP----KGAPTPPAATPPSPKGGPATPS-PKWAP-TP 965

Query: 238  TLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAPQGSG 279
                 P P+     P     P P AA P    G    P   G
Sbjct: 966  PAATPPSPKGGPATPSPKGAPTPPAATPPSPKGGPATPSPKG 1007



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 54/218 (24%), Positives = 76/218 (34%), Gaps = 23/218 (10%)

Query: 73   PAPGAAFLPVLNGVLPKPPAILGEPKGSCQEEAGPVRTAGLVATEPARGQCEDKDEEEKE 132
            PAP  A  P L  V+P  P  +     S ++   P  T     T       E        
Sbjct: 1497 PAPMGA--PTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATLAPKEALIPPAMT 1554

Query: 133  EQEEEEGAA--EPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVVPEVVAP 190
                ++  A   P+   A P     ++P A + S   G         P E L+ P V +P
Sbjct: 1555 VPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPS------PKELLIPPAVTSP 1608

Query: 191  AGFHVV--PAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQ-NNPVPRS 247
            +       PA  PP      A   P  T   P   P   +  P SP S T +    VP++
Sbjct: 1609 SPKEAPTPPAVTPPSPEKGPATPAPKGTPTSPPVTPSSLKDSPTSPASVTCKMGATVPQA 1668

Query: 248  RREVPPQLQP---------PVPEAAQPSPSAGCRGAPQ 276
             + +P +  P         P PE+  P  +A  R  PQ
Sbjct: 1669 SKGLPAKKGPTALKEVLVAPAPEST-PIITAPTRKGPQ 1705



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 29/91 (31%), Positives = 36/91 (39%), Gaps = 10/91 (10%)

Query: 189 APAGFHVVPAAP-----PPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQN-- 241
           AP    V P +P     PP      +  N P   +GPA  P P + P  S  SS+ +   
Sbjct: 864 APTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPAT-PAPKQAPALSMTSSSPKKAR 922

Query: 242 -NPVPRSRREVPPQLQPPVPEAA-QPSPSAG 270
             P P+     P     P P AA  PSP  G
Sbjct: 923 ATPAPKGIPASPSPKGAPTPPAATPPSPKGG 953



 Score = 31.6 bits (70), Expect = 4.3
 Identities = 62/249 (24%), Positives = 81/249 (32%), Gaps = 57/249 (22%)

Query: 63  ACEVCGFTPEPAPGAAFLP--VLNGVLPK-------PPAILGEPKGSCQEEAGPVRTAGL 113
           A E C   P P    A L   VL   +PK       PPA  G P G+ + + G   T+ L
Sbjct: 704 ASENCPVAPSPQNTCAPLATLVLAPEIPKSVPSPSLPPA--GTPPGTKKVD-GISHTSAL 760

Query: 114 VATEPARGQCEDKDEEEKEEQEEE------EGAAEPRGGWACPRCTLHNTPVASSCSVCG 167
                +  +C  +D         +        +  P G    P+     T   S+     
Sbjct: 761 APVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRPPTKKGSA----- 815

Query: 168 GPR----RLSLPRIPPEALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQ----G 219
           GP      LS P  P EA  +PE                 L  +G++ +P  T       
Sbjct: 816 GPDTPIGNLSSPVSPVEASFLPE---------------NSLSFQGSKDSPATTHSPTPPS 860

Query: 220 PAAEPEPPRVPPFSPFSSTLQ----------NNPVPRSRREVPPQLQPPVPEAAQPSP-S 268
           P   P P  V P SP   TL           N P P+     P   Q P       SP  
Sbjct: 861 PKGAPTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQAPALSMTSSSPKK 920

Query: 269 AGCRGAPQG 277
           A    AP+G
Sbjct: 921 ARATPAPKG 929


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 51/196 (26%), Positives = 75/196 (38%), Gaps = 27/196 (13%)

Query: 70  TPEPAPGAAFLPVLN-GVLPKPPAILGEPKGSCQEEAGPVRTAGLVA--TEPARGQCEDK 126
           +P P P +     L+ G+ P+PP            E GP   AGL++   E A     D+
Sbjct: 573 SPTPLPDSDEDEELDLGLGPRPPP-----------EPGPPDPAGLLSQTAEVALDLVGDR 621

Query: 127 D--EEEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVV 184
               E+ +E ++  G          P   + +        V  G   ++ P +    L +
Sbjct: 622 TPTSEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPL 681

Query: 185 PEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQNNPV 244
           P    P GF  +P  PPP  P  G    PP         P PP  PP  P + T+   P+
Sbjct: 682 PP---PPGFPPLPPPPPPPPPQPGFPMPPP-------LPPPPPPPPPAHP-AVTVPPPPL 730

Query: 245 PRSRREVPPQLQPPVP 260
           P      PP + PP+P
Sbjct: 731 PAPPGVPPPPILPPLP 746



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 75/265 (28%), Positives = 94/265 (35%), Gaps = 57/265 (21%)

Query: 115  ATEPARGQCEDKDE----EEKEEQEEEEGAAEPRGGWACPRCTLHNTPVASSCSVCGGPR 170
            ++E +    ED++E    EE+EE+EEEE  AE     A P     +   A+     G P 
Sbjct: 1124 SSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASAGPEDFEQDGEEAALAP--GAPA 1181

Query: 171  RLSLPRIPPEALVVPEVVAPAGFHVVPAAPP-----------------PGLPGEGA---- 209
              SL  +  E  +  E VAP     +   PP                 PGL  EGA    
Sbjct: 1182 VDSLG-MEEEVDIETEAVAPEERPSMLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLS 1240

Query: 210  --------EANPP-----ATSQGPAAEPEPPRVPPFSPFSSTLQNNPVPRSRREVPPQLQ 256
                    EA PP     A       EPEPP + P  P    L   P PR  R   P  +
Sbjct: 1241 PEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPL-PLQPPL---PPPRPPRPPSPPPE 1296

Query: 257  PPVPEAAQPS----PSAGCRGAPQGSGWAGASRLAELLSGKRLSVLEEEATEGGTSRVEA 312
            P   +A+ PS    P A     P   G  G+         K  S     AT GG   +  
Sbjct: 1297 PETTDASHPSVPPEPLAEDH-PPHTPGLCGSL-------AKSQSTETVPATPGGEPPLSG 1348

Query: 313  GSSTSGSDIIDLAGDTVRYTPASPS 337
            GSS        + G    Y   SPS
Sbjct: 1349 GSSGLSLSSPQVPGSPFSYPAPSPS 1373



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 54/213 (25%), Positives = 74/213 (34%), Gaps = 53/213 (24%)

Query: 86   VLPKPPAILG--EPKGSCQ--EEAGPVRT-AGLVATEPARGQCEDKDEEEKEEQEEEEGA 140
            +L +PP  +G  EP  S +  EE G  +  A L++ EP   + E +     E   E +  
Sbjct: 1206 MLDEPPLPVGVEEPADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLE 1265

Query: 141  AEPRGGWACPRCTLHNTPVASSCSVCGGPRRLSLPRIPPEALVVPEVVAPAGFHVVPAAP 200
             EP                         P  L LP  PP    +P    P      P +P
Sbjct: 1266 VEPEP-----------------------PMMLPLPLQPP----LPPPRPPR-----PPSP 1293

Query: 201  PPGLPGEGAEANPPATSQGPAAEPEPPRVPPF-SPFSSTLQNNPVPRSRREVPP------ 253
            PP    E  +A+ P+    P AE  PP  P      + +     VP +    PP      
Sbjct: 1294 PP--EPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTETVPATPGGEPPLSGGSS 1351

Query: 254  ---QLQPPVPEA----AQPSPSAGCRGAPQGSG 279
                  P VP +      PSPS    G P+  G
Sbjct: 1352 GLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPG 1384


>gi|162329583 cleavage and polyadenylation specific factor 6, 68 kD
           subunit [Homo sapiens]
          Length = 551

 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 33/103 (32%), Positives = 38/103 (36%), Gaps = 10/103 (9%)

Query: 165 VCGGPRRLSLPRIPPEALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEP 224
           + G P R   P  PP  L   +         +P  PPP +PG G    PP   QGP   P
Sbjct: 263 LAGPPNRGDRP--PPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPGPPPPQQGPPPPP 320

Query: 225 EPPRVPPFSPFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSP 267
            P    P  P    L   P        PP L  P P A  P+P
Sbjct: 321 GPFPPRPPGPLGPPLTLAP--------PPHLPGPPPGAPPPAP 355



 Score = 39.3 bits (90), Expect = 0.020
 Identities = 33/96 (34%), Positives = 34/96 (35%), Gaps = 15/96 (15%)

Query: 190 PAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQNNPVPRSRR 249
           PAG    P  PPP  P   A   PP    GP   P PP  PP           P  R  R
Sbjct: 220 PAG----PGGPPPPFP---AGQTPPRPPLGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDR 272

Query: 250 EVPPQL-------QPPV-PEAAQPSPSAGCRGAPQG 277
             PP L       QPP+ P    P P     G P G
Sbjct: 273 PPPPVLFPGQPFGQPPLGPLPPGPPPPVPGYGPPPG 308



 Score = 35.4 bits (80), Expect = 0.29
 Identities = 31/98 (31%), Positives = 34/98 (34%), Gaps = 17/98 (17%)

Query: 178 PPEALVVPEVVAPAGFHVVPAAPPPGLPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSS 237
           PP     P    P G   +  APPP LPG    A PPA    PA  P P           
Sbjct: 318 PPPGPFPPRPPGPLG-PPLTLAPPPHLPGPPPGAPPPAPHVNPAFFPPP----------- 365

Query: 238 TLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAP 275
              N+ +P S    PP   P  P    P    G  G P
Sbjct: 366 --TNSGMPTSDSRGPP---PTDPYGRPPPYDRGDYGPP 398



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 30/102 (29%), Positives = 31/102 (30%), Gaps = 22/102 (21%)

Query: 188 VAPAGFHVVPAAPPPGL---------PGEGAEANPPATSQG-----PAAEPEPPRVPPFS 233
           + P G    P  PPPG          P  G    PP    G     P   P PP  PP  
Sbjct: 241 LGPPGPPGPPGPPPPGQVLPPPLAGPPNRGDRPPPPVLFPGQPFGQPPLGPLPPGPPPPV 300

Query: 234 PFSSTLQNNPVPRSRREVPPQLQPPVPEAAQPSPSAGCRGAP 275
           P        P        PPQ  PP P    P    G  G P
Sbjct: 301 PGYGPPPGPP--------PPQQGPPPPPGPFPPRPPGPLGPP 334



 Score = 31.6 bits (70), Expect = 4.3
 Identities = 26/84 (30%), Positives = 28/84 (33%), Gaps = 9/84 (10%)

Query: 197 PAAPPPG--LPGEGAEANPPATSQGPAAEPEPPRVPPFSPFSSTLQNNPVPRSRREV-PP 253
           P A P G   PG      PP         P PP  PP  P        P P    +V PP
Sbjct: 208 PGAVPGGDRFPGPAGPGGPPPPFPAGQTPPRPPLGPPGPP------GPPGPPPPGQVLPP 261

Query: 254 QLQPPVPEAAQPSPSAGCRGAPQG 277
            L  P     +P P     G P G
Sbjct: 262 PLAGPPNRGDRPPPPVLFPGQPFG 285


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.432 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 53,456,255
Number of Sequences: 37866
Number of extensions: 3158356
Number of successful extensions: 34497
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 225
Number of HSP's successfully gapped in prelim test: 1147
Number of HSP's that attempted gapping in prelim test: 23406
Number of HSP's gapped (non-prelim): 9032
length of query: 1086
length of database: 18,247,518
effective HSP length: 113
effective length of query: 973
effective length of database: 13,968,660
effective search space: 13591506180
effective search space used: 13591506180
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.