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Search of human proteins with 5031877
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|5031877 lamin B1 [Homo sapiens]
(586 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|5031877 lamin B1 [Homo sapiens] 1125 0.0
gi|27436951 lamin B2 [Homo sapiens] 671 0.0
gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens] 610 e-174
gi|5031875 lamin A/C isoform 2 [Homo sapiens] 609 e-174
gi|27436948 lamin A/C isoform 3 [Homo sapiens] 591 e-169
gi|55749932 desmin [Homo sapiens] 181 2e-45
gi|21264345 peripherin [Homo sapiens] 169 5e-42
gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens] 165 1e-40
gi|196115290 glial fibrillary acidic protein isoform 2 [Homo sap... 163 4e-40
gi|62414289 vimentin [Homo sapiens] 163 5e-40
gi|14249342 internexin neuronal intermediate filament protein, a... 146 6e-35
gi|47132620 keratin 2 [Homo sapiens] 145 1e-34
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 139 9e-33
gi|15431310 keratin 14 [Homo sapiens] 137 2e-32
gi|153791670 keratin 76 [Homo sapiens] 135 8e-32
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 134 2e-31
gi|119395750 keratin 1 [Homo sapiens] 134 2e-31
gi|109255249 keratin 4 [Homo sapiens] 134 3e-31
gi|14917119 keratin 34 [Homo sapiens] 132 1e-30
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 132 1e-30
gi|153791158 keratin 75 [Homo sapiens] 131 2e-30
gi|131412225 keratin 13 isoform a [Homo sapiens] 131 2e-30
gi|14917117 keratin 33A [Homo sapiens] 131 2e-30
gi|109148552 keratin 3 [Homo sapiens] 130 3e-30
gi|14917115 keratin 31 [Homo sapiens] 130 4e-30
gi|148612803 keratin 6 irs4 [Homo sapiens] 129 6e-30
gi|15431318 keratin 38 [Homo sapiens] 129 6e-30
gi|10337581 type I hair keratin 3B [Homo sapiens] 128 1e-29
gi|125628636 keratin 80 isoform a [Homo sapiens] 128 2e-29
gi|24430192 keratin 16 [Homo sapiens] 128 2e-29
>gi|5031877 lamin B1 [Homo sapiens]
Length = 586
Score = 1125 bits (2910), Expect = 0.0
Identities = 586/586 (100%), Positives = 586/586 (100%)
Query: 1 MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSAL 60
MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSAL
Sbjct: 1 MATATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSAL 60
Query: 61 QLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLN 120
QLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLN
Sbjct: 61 QLQVTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLN 120
Query: 121 YAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAA 180
YAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAA
Sbjct: 121 YAKKESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAA 180
Query: 181 KKQLADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEY 240
KKQLADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEY
Sbjct: 181 KKQLADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEY 240
Query: 241 KLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRI 300
KLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRI
Sbjct: 241 KLAQALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRI 300
Query: 301 ESLSSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDY 360
ESLSSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDY
Sbjct: 301 ESLSSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDY 360
Query: 361 EQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRVD 420
EQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRVD
Sbjct: 361 EQLLDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRVD 420
Query: 421 VEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSV 480
VEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSV
Sbjct: 421 VEESEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTSV 480
Query: 481 SYKYTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVA 540
SYKYTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVA
Sbjct: 481 SYKYTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVA 540
Query: 541 QRSTVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM 586
QRSTVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM
Sbjct: 541 QRSTVFKTTIPEEEEEEEEAAGVVVEEELFHQQGTPRASNRSCAIM 586
>gi|27436951 lamin B2 [Homo sapiens]
Length = 600
Score = 671 bits (1731), Expect = 0.0
Identities = 353/604 (58%), Positives = 459/604 (75%), Gaps = 26/604 (4%)
Query: 4 ATPVPPRMGSRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQ 63
ATP+P RAGGP TPLSPTRLSRLQEKEELRELNDRLA YID+VR+LE EN L L+
Sbjct: 2 ATPLP----GRAGGPATPLSPTRLSRLQEKEELRELNDRLAHYIDRVRALELENDRLLLK 57
Query: 64 VTEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAK 123
++E+EEV RE++G+KALYE+ELADARR LD+TARERA+LQIE+GK +AE D++ + K
Sbjct: 58 ISEKEEVTTREVSGIKALYESELADARRVLDETARERARLQIEIGKLRAELDEVNKSAKK 117
Query: 124 KESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQ 183
+E +L AQ ++++ E+ + + LA AL DK+ LE D+ +L+ Q+A+ E A AKKQ
Sbjct: 118 REGELTVAQGRVKDLESLFHRSEVELAAALSDKRGLESDVAELRAQLAKAEDGHAVAKKQ 177
Query: 184 LADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLA 243
L ETL++VDLENRCQSL E+L+FRKS++EEE+ ETRR+HE RLVEVDS RQ EY++K+A
Sbjct: 178 LEKETLMRVDLENRCQSLQEELDFRKSVFEEEVRETRRRHERRLVEVDSSRQQEYDFKMA 237
Query: 244 QALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESL 303
QAL E+R QHD QVRLYK ELEQTY AKL++A+LSS+ N ++AREEL E+RMR+ESL
Sbjct: 238 QALEELRSQHDEQVRLYKLELEQTYQAKLDSAKLSSDQNDKAASAAREELKEARMRLESL 297
Query: 304 SSQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQL 363
S QLS LQK++ A +RI+ELE+ +A E+D R+ML KE+EM E+RD MQQQL +Y++L
Sbjct: 298 SYQLSGLQKQASAAEDRIRELEEAMAGERDKFRKMLDAKEQEMTEMRDVMQQQLAEYQEL 357
Query: 364 LDVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRS------VRTTRGKRK 417
LDVKLALDMEI+AYRKLLEGEEERLKLSPSPSSRVTVSRA+SS S R R KRK
Sbjct: 358 LDVKLALDMEINAYRKLLEGEEERLKLSPSPSSRVTVSRATSSSSGSLSATGRLGRSKRK 417
Query: 418 RVDVEE------------SEASSSVSISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQP 465
R++VEE + S ++ ASA+G+V IEEID++GKF++LKN S++DQ
Sbjct: 418 RLEVEEPLGSGPSVLGTGTGGSGGFHLAQQASASGSVSIEEIDLEGKFVQLKNNSDKDQS 477
Query: 466 MGGWEMIRKIGD-TSVSYKYTSRYVLKAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTG 524
+G W + R++ + ++YK+T +Y+L+AGQ VT+WAA AGV SPP+ L+WK Q+SWGTG
Sbjct: 478 LGNWRIKRQVLEGEEIAYKFTPKYILRAGQMVTVWAAGAGVAHSPPSTLVWKGQSSWGTG 537
Query: 525 EDVKVILKNSQGEEVAQRSTVFKTTIPEEEE--EEEEAAGVVVEEELFHQQGTPRASNRS 582
E + +L N+ GEEVA R TV K+++ E E EEEE EE+LFHQQG PR ++R
Sbjct: 538 ESFRTVLVNADGEEVAMR-TVKKSSVMRENENGEEEEEEAEFGEEDLFHQQGDPRTTSRG 596
Query: 583 CAIM 586
C +M
Sbjct: 597 CYVM 600
>gi|27436946 lamin A/C isoform 1 precursor [Homo sapiens]
Length = 664
Score = 610 bits (1572), Expect = e-174
Identities = 315/570 (55%), Positives = 430/570 (75%), Gaps = 10/570 (1%)
Query: 13 SRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRG 72
S A +TPLSPTR++RLQEKE+L+ELNDRLAVYID+VRSLETEN+ L+L++TE EEV
Sbjct: 12 SGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVS 71
Query: 73 RELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQ 132
RE++G+KA YE EL DAR+ LD A+ERA+LQ+EL K + E +L KKE DL AQ
Sbjct: 72 REVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQ 131
Query: 133 IKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKV 192
+L++ EA LNSK+AAL+TAL +K++LEG+L DL+ Q+A+LEA+L AKKQL DE L +V
Sbjct: 132 ARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRV 191
Query: 193 DLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQ 252
D ENR Q++ E+L+F+K++Y EE+ ET+R+HETRLVE+D+G+Q E+E +LA AL E+R Q
Sbjct: 192 DAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQ 251
Query: 253 HDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQK 312
H+ QV YK+ELE+TY AKL+NAR S+E N++ V +A EEL +SR+RI+SLS+QLS LQK
Sbjct: 252 HEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQK 311
Query: 313 ESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDM 372
+ A ++++LED LA+E+D SRR+L +KEREMAE+R +MQQQL++Y++LLD+KLALDM
Sbjct: 312 QLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDM 371
Query: 373 EISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGK-RKRVDVEESEASSSVS 431
EI AYRKLLEGEEERL+LSPSP+S+ + RASS S G K+ +E +E+ S S
Sbjct: 372 EIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRS--S 429
Query: 432 ISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTS-VSYKYTSRYVL 490
S A +G V +EE+D +GKF+RL+N S +DQ MG W++ R+ GD ++Y++ ++ L
Sbjct: 430 FSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTL 489
Query: 491 KAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTI 550
KAGQ VTIWAA AG T SPPTDL+WK QN+WG G ++ L NS GEEVA R V T+
Sbjct: 490 KAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTV 549
Query: 551 PEEEEEEEEAAGVVVEEELFHQQGTPRASN 580
E++E+E+ ++ L H G+ +S+
Sbjct: 550 VEDDEDEDG------DDLLHHHHGSHCSSS 573
>gi|5031875 lamin A/C isoform 2 [Homo sapiens]
Length = 572
Score = 609 bits (1571), Expect = e-174
Identities = 311/548 (56%), Positives = 421/548 (76%), Gaps = 4/548 (0%)
Query: 13 SRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRG 72
S A +TPLSPTR++RLQEKE+L+ELNDRLAVYID+VRSLETEN+ L+L++TE EEV
Sbjct: 12 SGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVS 71
Query: 73 RELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQ 132
RE++G+KA YE EL DAR+ LD A+ERA+LQ+EL K + E +L KKE DL AQ
Sbjct: 72 REVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQ 131
Query: 133 IKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKV 192
+L++ EA LNSK+AAL+TAL +K++LEG+L DL+ Q+A+LEA+L AKKQL DE L +V
Sbjct: 132 ARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRV 191
Query: 193 DLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQ 252
D ENR Q++ E+L+F+K++Y EE+ ET+R+HETRLVE+D+G+Q E+E +LA AL E+R Q
Sbjct: 192 DAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQ 251
Query: 253 HDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQK 312
H+ QV YK+ELE+TY AKL+NAR S+E N++ V +A EEL +SR+RI+SLS+QLS LQK
Sbjct: 252 HEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQK 311
Query: 313 ESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDM 372
+ A ++++LED LA+E+D SRR+L +KEREMAE+R +MQQQL++Y++LLD+KLALDM
Sbjct: 312 QLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDM 371
Query: 373 EISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGK-RKRVDVEESEASSSVS 431
EI AYRKLLEGEEERL+LSPSP+S+ + RASS S G K+ +E +E+ S S
Sbjct: 372 EIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRS--S 429
Query: 432 ISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTS-VSYKYTSRYVL 490
S A +G V +EE+D +GKF+RL+N S +DQ MG W++ R+ GD ++Y++ ++ L
Sbjct: 430 FSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTL 489
Query: 491 KAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGEEVAQRSTVFKTTI 550
KAGQ VTIWAA AG T SPPTDL+WK QN+WG G ++ L NS GEEVA R V T+
Sbjct: 490 KAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTV 549
Query: 551 PEEEEEEE 558
E++E+E+
Sbjct: 550 VEDDEDED 557
>gi|27436948 lamin A/C isoform 3 [Homo sapiens]
Length = 634
Score = 591 bits (1524), Expect = e-169
Identities = 302/527 (57%), Positives = 407/527 (77%), Gaps = 4/527 (0%)
Query: 13 SRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRG 72
S A +TPLSPTR++RLQEKE+L+ELNDRLAVYID+VRSLETEN+ L+L++TE EEV
Sbjct: 12 SGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVVS 71
Query: 73 RELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQ 132
RE++G+KA YE EL DAR+ LD A+ERA+LQ+EL K + E +L KKE DL AQ
Sbjct: 72 REVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQ 131
Query: 133 IKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKV 192
+L++ EA LNSK+AAL+TAL +K++LEG+L DL+ Q+A+LEA+L AKKQL DE L +V
Sbjct: 132 ARLKDLEALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRV 191
Query: 193 DLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQ 252
D ENR Q++ E+L+F+K++Y EE+ ET+R+HETRLVE+D+G+Q E+E +LA AL E+R Q
Sbjct: 192 DAENRLQTMKEELDFQKNIYSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQ 251
Query: 253 HDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQK 312
H+ QV YK+ELE+TY AKL+NAR S+E N++ V +A EEL +SR+RI+SLS+QLS LQK
Sbjct: 252 HEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQK 311
Query: 313 ESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDM 372
+ A ++++LED LA+E+D SRR+L +KEREMAE+R +MQQQL++Y++LLD+KLALDM
Sbjct: 312 QLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDM 371
Query: 373 EISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGK-RKRVDVEESEASSSVS 431
EI AYRKLLEGEEERL+LSPSP+S+ + RASS S G K+ +E +E+ S S
Sbjct: 372 EIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRKLESTESRS--S 429
Query: 432 ISHSASATGNVCIEEIDVDGKFIRLKNTSEQDQPMGGWEMIRKIGDTS-VSYKYTSRYVL 490
S A +G V +EE+D +GKF+RL+N S +DQ MG W++ R+ GD ++Y++ ++ L
Sbjct: 430 FSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTL 489
Query: 491 KAGQTVTIWAANAGVTASPPTDLIWKNQNSWGTGEDVKVILKNSQGE 537
KAGQ VTIWAA AG T SPPTDL+WK QN+WG G ++ L NS GE
Sbjct: 490 KAGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGE 536
>gi|55749932 desmin [Homo sapiens]
Length = 470
Score = 181 bits (459), Expect = 2e-45
Identities = 124/408 (30%), Positives = 209/408 (51%), Gaps = 52/408 (12%)
Query: 28 SRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELA 87
+R EK EL+ELNDR A YI+KVR LE +N+AL +V ++GRE T + LYE EL
Sbjct: 104 TRTNEKVELQELNDRFANYIEKVRFLEQQNAALAAEVNR---LKGREPTRVAELYEEELR 160
Query: 88 DARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDA 147
+ RR ++ +RA++ +E D LL DL + KL+E
Sbjct: 161 ELRRQVEVLTNQRARVDVE-------RDNLL-------DDLQRLKAKLQE---------- 196
Query: 148 ALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEF 207
E L++ + E +LAA + + TL ++DLE R +SL E++ F
Sbjct: 197 ------------EIQLKE------EAENNLAAFRADVDAATLARIDLERRIESLNEEIAF 238
Query: 208 RKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQT 267
K ++EEEI E + + + + V+V+ + L AL ++R Q++ E E+
Sbjct: 239 LKKVHEEEIRELQAQLQEQQVQVEMDMS---KPDLTAALRDIRAQYETIAAKNISEAEEW 295
Query: 268 YHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDL 327
Y +K+ + ++ N + A++E+ME R +I+S + ++ L+ + + + +++ELED
Sbjct: 296 YKSKVSDLTQAANKNNDALRQAKQEMMEYRHQIQSYTCEIDALKGTNDSLMRQMRELEDR 355
Query: 328 LAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEER 387
A E + + E E+ ++D+M + L +Y+ LL+VK+ALD+EI+ YRKLLEGEE R
Sbjct: 356 FASEASGYQDNIARLEEEIRHLKDEMARHLREYQDLLNVKMALDVEIATYRKLLEGEESR 415
Query: 388 LKLSPSPSSRVTVSRASSSRSVRTTRGKR----KRVDVEESEASSSVS 431
+ L S + S + K+ K ++ + E S +
Sbjct: 416 INLPIQTYSALNFRETSPEQRGSEVHTKKTVMIKTIETRDGEVVSEAT 463
>gi|21264345 peripherin [Homo sapiens]
Length = 470
Score = 169 bits (429), Expect = 5e-42
Identities = 115/367 (31%), Positives = 199/367 (54%), Gaps = 54/367 (14%)
Query: 28 SRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELA 87
+R EK+EL+ELNDR A +I+KVR LE +N+AL+ E + RG+E L + EL
Sbjct: 93 TRSNEKQELQELNDRFANFIEKVRFLEQQNAALR---GELSQARGQEPARADQLCQQELR 149
Query: 88 DARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDA 147
+ RR L+ RER ++Q+E + L E AAL
Sbjct: 150 ELRRELELLGRERDRVQVE-------------------------RDGLAEDLAAL----- 179
Query: 148 ALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEF 207
K+ LE + +D E +L +K + D TL +++LE + +SL +++EF
Sbjct: 180 --------KQRLEEETRKREDA----EHNLVLFRKDVDDATLSRLELERKIESLMDEIEF 227
Query: 208 RKSMYEEEINETRRKHETRLVEVDSGRQIEYEY----KLAQALHEMREQHDAQVRLYKEE 263
K ++EEE+ + + E++ V+ Q+E E +L AL ++R Q+++ +E
Sbjct: 228 LKKLHEEELRDLQVSVESQQVQ-----QVEVEATVKPELTAALRDIRAQYESIAAKNLQE 282
Query: 264 LEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQE 323
E+ Y +K + ++ N + A++E+ ESR +I+SL+ ++ L+ + A L +++E
Sbjct: 283 AEEWYKSKYADLSDAANRNHEALRQAKQEMNESRRQIQSLTCEVDGLRGTNEALLRQLRE 342
Query: 324 LEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEG 383
LE+ A E + E E+ +++++M + L +Y++LL+VK+ALD+EI+ YRKLLEG
Sbjct: 343 LEEQFALEAGGYQAGAARLEEELRQLKEEMARHLREYQELLNVKMALDIEIATYRKLLEG 402
Query: 384 EEERLKL 390
EE R+ +
Sbjct: 403 EESRISV 409
>gi|4503979 glial fibrillary acidic protein isoform 1 [Homo sapiens]
Length = 432
Score = 165 bits (417), Expect = 1e-40
Identities = 124/435 (28%), Positives = 209/435 (48%), Gaps = 57/435 (13%)
Query: 6 PVPPRMG-SRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQV 64
P+P R+ S AG TR S E+ E+ ELNDR A YI+KVR LE +N AL
Sbjct: 45 PLPTRVDFSLAGALNAGFKETRAS---ERAEMMELNDRFASYIEKVRFLEQQNKAL---A 98
Query: 65 TEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKK 124
E ++R +E T L +Y+ EL + R LD A+L++ E D L + A
Sbjct: 99 AELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEV-------ERDNLAQDLA-- 149
Query: 125 ESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQL 184
++ L+D + + E +LAA +++
Sbjct: 150 ---------------------------------TVRQKLQDETNLRLEAENNLAAYRQEA 176
Query: 185 ADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQ 244
+ TL ++DLE + +SL E++ F + ++EEE+ E + + + V V+ + L
Sbjct: 177 DEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVA---KPDLTA 233
Query: 245 ALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLS 304
AL E+R Q++A E E+ Y +K + ++ N + A+ E + R +++SL+
Sbjct: 234 ALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLT 293
Query: 305 SQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLL 364
L +L+ + + +++E E+ +E + + L E E ++D+M + L +Y+ LL
Sbjct: 294 CDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLL 353
Query: 365 DVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRAS-SSRSVRTTRGKR----KRV 419
+VKLALD+EI+ YRKLLEGEE R+ + S + + S ++SV KR K V
Sbjct: 354 NVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRETSLDTKSVSEGHLKRNIVVKTV 413
Query: 420 DVEESEASSSVSISH 434
++ + E H
Sbjct: 414 EMRDGEVIKESKQEH 428
>gi|196115290 glial fibrillary acidic protein isoform 2 [Homo
sapiens]
Length = 431
Score = 163 bits (413), Expect = 4e-40
Identities = 116/403 (28%), Positives = 198/403 (49%), Gaps = 52/403 (12%)
Query: 6 PVPPRMG-SRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQV 64
P+P R+ S AG TR S E+ E+ ELNDR A YI+KVR LE +N AL
Sbjct: 45 PLPTRVDFSLAGALNAGFKETRAS---ERAEMMELNDRFASYIEKVRFLEQQNKAL---A 98
Query: 65 TEREEVRGRELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKK 124
E ++R +E T L +Y+ EL + R LD A+L++ E D L + A
Sbjct: 99 AELNQLRAKEPTKLADVYQAELRELRLRLDQLTANSARLEV-------ERDNLAQDLA-- 149
Query: 125 ESDLNGAQIKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQL 184
++ L+D + + E +LAA +++
Sbjct: 150 ---------------------------------TVRQKLQDETNLRLEAENNLAAYRQEA 176
Query: 185 ADETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQ 244
+ TL ++DLE + +SL E++ F + ++EEE+ E + + + V V+ + L
Sbjct: 177 DEATLARLDLERKIESLEEEIRFLRKIHEEEVRELQEQLARQQVHVELDVA---KPDLTA 233
Query: 245 ALHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLS 304
AL E+R Q++A E E+ Y +K + ++ N + A+ E + R +++SL+
Sbjct: 234 ALKEIRTQYEAMASSNMHEAEEWYRSKFADLTDAAARNAELLRQAKHEANDYRRQLQSLT 293
Query: 305 SQLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLL 364
L +L+ + + +++E E+ +E + + L E E ++D+M + L +Y+ LL
Sbjct: 294 CDLESLRGTNESLERQMREQEERHVREAASYQEALARLEEEGQSLKDEMARHLQEYQDLL 353
Query: 365 DVKLALDMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSR 407
+VKLALD+EI+ YRKLLEGEE R+ + S + + S++
Sbjct: 354 NVKLALDIEIATYRKLLEGEENRITIPVQTFSNLQIRGGKSTK 396
>gi|62414289 vimentin [Homo sapiens]
Length = 466
Score = 163 bits (412), Expect = 5e-40
Identities = 118/412 (28%), Positives = 210/412 (50%), Gaps = 53/412 (12%)
Query: 28 SRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELA 87
+R EK EL+ELNDR A YIDKVR LE +N L + E E+++G+ + L LYE E+
Sbjct: 99 TRTNEKVELQELNDRFANYIDKVRFLEQQNKIL---LAELEQLKGQGKSRLGDLYEEEMR 155
Query: 88 DARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDA 147
+ RR +D ++A++++ E D L + + L ++ E E L
Sbjct: 156 ELRRQVDQLTNDKARVEV-------ERDNLAEDIMRLREKLQEEMLQREEAENTL----- 203
Query: 148 ALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEF 207
+S D+++ ASLA ++DLE + +SL E++ F
Sbjct: 204 ---------QSFRQDVDN---------ASLA------------RLDLERKVESLQEEIAF 233
Query: 208 RKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQT 267
K ++EEEI E + + + + V++D + L AL ++R+Q+++ +E E+
Sbjct: 234 LKKLHEEEIQELQAQIQEQHVQIDVDVS---KPDLTAALRDVRQQYESVAAKNLQEAEEW 290
Query: 268 YHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDL 327
Y +K + ++ N + A++E E R +++SL+ ++ L+ + + +++E+E+
Sbjct: 291 YKSKFADLSEAANRNNDALRQAKQESTEYRRQVQSLTCEVDALKGTNESLERQMREMEEN 350
Query: 328 LAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEER 387
A E N + + + E+ ++++M + L +Y+ LL+VK+ALD+EI+ YRKLLEGEE R
Sbjct: 351 FAVEAANYQDTIGRLQDEIQNMKEEMARHLREYQDLLNVKMALDIEIATYRKLLEGEESR 410
Query: 388 LKLS-PSPSSRVTVSRASSSRSVRTTRGKR----KRVDVEESEASSSVSISH 434
+ L P+ SS S + T KR K V+ + + + S H
Sbjct: 411 ISLPLPNFSSLNLRETNLDSLPLVDTHSKRTLLIKTVETRDGQVINETSQHH 462
>gi|14249342 internexin neuronal intermediate filament protein,
alpha [Homo sapiens]
Length = 499
Score = 146 bits (368), Expect = 6e-35
Identities = 112/419 (26%), Positives = 201/419 (47%), Gaps = 59/419 (14%)
Query: 26 RLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETE 85
++ R EKE+L+ LNDR AV+I+KV LET+N AL+ ++ + R E + + L++ E
Sbjct: 88 KIIRTNEKEQLQGLNDRFAVFIEKVHQLETQNRALEAELAALRQ-RHAEPSRVGELFQRE 146
Query: 86 LADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSK 145
L D L+ +L + + Q LL ++ + + E
Sbjct: 147 LRD--------------LRAQLEEASSARSQALLERDGLAEEVQRLRARCEE-------- 184
Query: 146 DAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDL 205
+ + EG E +L A ++ + TL ++DLE + +SL ++L
Sbjct: 185 ---------ESRGREG-----------AERALKAQQRDVDGATLARLDLEKKVESLLDEL 224
Query: 206 EFRKSMYEEEINE---TRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKE 262
F + +++EE+ E T + EVD + L AL E+R Q+++ +
Sbjct: 225 AFVRQVHDEEVAELLATLQASSQAAAEVDV---TVAKPDLTSALREIRAQYESLAAKNLQ 281
Query: 263 ELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQ 322
E+ Y +K N + +T + ++REE+ E R ++++ + ++ L+ + + +I
Sbjct: 282 SAEEWYKSKFANLNEQAARSTEAIRASREEIHEYRRQLQARTIEIEGLRGANESLERQIL 341
Query: 323 ELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLE 382
ELE+ + E + + E ++ + +M + L +Y+ LL+VK+ALD+EI+AYRKLLE
Sbjct: 342 ELEERHSAEVAGYQDSIGQLENDLRNTKSEMARHLREYQDLLNVKMALDIEIAAYRKLLE 401
Query: 383 GEEERLKLS----------PSPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVS 431
GEE R S P+PS + S++ S ++ G + + EE EAS S
Sbjct: 402 GEETRFSTSGLSISGLNPLPNPSYLLPPRILSATTSKVSSTGLSLKKEEEEEEASKVAS 460
>gi|47132620 keratin 2 [Homo sapiens]
Length = 639
Score = 145 bits (366), Expect = 1e-34
Identities = 102/383 (26%), Positives = 192/383 (50%), Gaps = 51/383 (13%)
Query: 29 RLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVR-GRELTGLKALYETELA 87
+ QE+E+++ LN++ A +IDKVR LE +N LQ + +++ G L+ +++ +
Sbjct: 175 KAQEREQIKTLNNKFASFIDKVRFLEQQNQVLQTKWELLQQMNVGTRPINLEPIFQGYID 234
Query: 88 DARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDA 147
+R LD ER EL + L+ +Y KK YE +N + A
Sbjct: 235 SLKRYLDGLTAERTSQNSELNNMQ----DLVEDYKKK-------------YEDEINKRTA 277
Query: 148 ALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEF 207
A E KK + + ++KV+L+++ L +++EF
Sbjct: 278 A-------------------------ENDFVTLKKDVDNAYMIKVELQSKVDLLNQEIEF 312
Query: 208 RKSMYEEEINETRRK--HETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELE 265
K +Y+ EI++ + ++ +D+ R ++ + +A E++ Q++ + KEE E
Sbjct: 313 LKVLYDAEISQIHQSVTDTNVILSMDNSRNLDLDSIIA----EVKAQYEEIAQRSKEEAE 368
Query: 266 QTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELE 325
YH+K E +++ + ++ + E+ E I+ L ++++++K+ + + I + E
Sbjct: 369 ALYHSKYEELQVTVGRHGDSLKEIKIEISELNRVIQRLQGEIAHVKKQCKNVQDAIADAE 428
Query: 326 DLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEE 385
++R L D E + + ++ + + L DY++L++VKLALD+EI+ YRKLLEGEE
Sbjct: 429 QRGEHALKDARNKLNDLEEALQQAKEDLARLLRDYQELMNVKLALDVEIATYRKLLEGEE 488
Query: 386 ERLKLSPSPSSRVTVSRASSSRS 408
++S SS VTVS SS+ S
Sbjct: 489 --CRMSGDLSSNVTVSVTSSTIS 509
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 139 bits (349), Expect = 9e-33
Identities = 116/468 (24%), Positives = 217/468 (46%), Gaps = 68/468 (14%)
Query: 13 SRAGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRG 72
S G + P +LSR EKE+L+ LNDR A YI+KV LE +N ++ ++ + +
Sbjct: 82 SLLNGGSGPGGDYKLSRSNEKEQLQGLNDRFAGYIEKVHYLEQQNKEIEAEIQALRQKQA 141
Query: 73 RELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQ 132
L Y+ E+ + R L+ ++N+ K AQ
Sbjct: 142 SHAQ-LGDAYDQEIRELRATLE-----------------------MVNHEK-------AQ 170
Query: 133 IKLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQ-------LEASLAAAKKQLA 185
++L D LE D+ LK++ + EA++ A +K +
Sbjct: 171 VQL-------------------DSDHLEEDIHRLKERFEEEARLRDDTEAAIRALRKDIE 211
Query: 186 DETLLKVDLENRCQSLTEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQA 245
+ +L+KV+L+ + QSL +++ F +S +EEE+ + + + + V+ R+ + ++ A
Sbjct: 212 EASLVKVELDKKVQSLQDEVAFLRSNHEEEVADLLAQIQASHITVE--RKDYLKTDISTA 269
Query: 246 LHEMREQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSS 305
L E+R Q ++ + E+ + + ++E N + SA+EE+ E R +++S S
Sbjct: 270 LKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEEIAEYRRQLQSKSI 329
Query: 306 QLSNLQKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLD 365
+L +++ + ++ ++E+ + + + + E E+ + +M + L +Y+ LL+
Sbjct: 330 ELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQQLENELRGTKWEMARHLREYQDLLN 389
Query: 366 VKLALDMEISAYRKLLEGEEERLK------LSPSPSSR--VTVSRASSSRSVRTTRGKRK 417
VK+ALD+EI+AYRKLLEGEE R P + R +T+S V + K +
Sbjct: 390 VKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSKIQKPKVEAPKLKVQ 449
Query: 418 RVDVEESEASSSVSISHSASATGNVCI-EEIDVDGKFIRLKNTSEQDQ 464
VEE + V S I EE+ V K + + E+++
Sbjct: 450 HKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEE 497
>gi|15431310 keratin 14 [Homo sapiens]
Length = 472
Score = 137 bits (346), Expect = 2e-32
Identities = 109/402 (27%), Positives = 195/402 (48%), Gaps = 57/402 (14%)
Query: 32 EKEELRELNDRLAVYIDKVRSLETENSALQLQVTE-REEVRGRELTGLKALYETELADAR 90
EK ++ LNDRLA Y+DKVR+LE N+ L++++ + + R E+ ++T + D R
Sbjct: 115 EKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPAEIKDYSPYFKT-IEDLR 173
Query: 91 RALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALA 150
+ + A + +++ + D Y
Sbjct: 174 NKILTATVDNANVLLQIDNARLAADDFRTKYE---------------------------- 205
Query: 151 TALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKS 210
T L + S+E D+ L+ + +L TL + DLE + +SL E+L + K
Sbjct: 206 TELNLRMSVEADINGLRRVLDEL--------------TLARADLEMQIESLKEELAYLKK 251
Query: 211 MYEEEINETRRKHETRL-VEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYH 269
+EEE+N R + + VE+D+ ++ L++ L+EMR+Q++ +++ E+ +
Sbjct: 252 NHEEEMNALRGQVGGDVNVEMDAAPGVD----LSRILNEMRDQYEKMAEKNRKDAEEWFF 307
Query: 270 AKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLER-IQELEDLL 328
K E N+ V S + E+ E R +++L +L + Q +A LE ++E +
Sbjct: 308 TKTEELNREVATNSELVQSGKSEISELRRTMQNLEIELQS-QLSMKASLENSLEETKGRY 366
Query: 329 AKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERL 388
+ + M+ E ++A++R +M+QQ +Y+ LLDVK L+ EI+ YR+LLEGE+ L
Sbjct: 367 CMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYRRLLEGEDAHL 426
Query: 389 KLSP-SPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSS 429
S S S+ + SSSR +RT K +DV + + S+
Sbjct: 427 SSSQFSSGSQSSRDVTSSSRQIRT-----KVMDVHDGKVVST 463
>gi|153791670 keratin 76 [Homo sapiens]
Length = 638
Score = 135 bits (341), Expect = 8e-32
Identities = 109/417 (26%), Positives = 206/417 (49%), Gaps = 53/417 (12%)
Query: 29 RLQEKEELRELNDRLAVYIDKVRSLETENSALQLQ-VTEREEVRGRELTGLKALYETELA 87
+ QE+E+++ LN++ A +IDKVR LE +N L+ + +++ G + L+ +E+ ++
Sbjct: 180 KAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWELLQQQTTGSGPSSLEPCFESYIS 239
Query: 88 DARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDA 147
+ LD ER L+ G+ K+ D L+ ++ KK YE +N + A
Sbjct: 240 FLCKQLDSLLGERGNLE---GELKSMQD-LVEDFKKK-------------YEDEINKRTA 282
Query: 148 ALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEF 207
A +G KK ++ + KV+L+ + SLT+++ F
Sbjct: 283 AENEFVGLKKDVDAAFMN-------------------------KVELQAKVDSLTDEVSF 317
Query: 208 RKSMYEEEINETR-RKHETRLV-EVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELE 265
+++YE E+++ + +T +V +D+ R ++ L + E+R Q++ + K E E
Sbjct: 318 LRTLYEMELSQMQSHASDTSVVLSMDNNRCLD----LGSIIAEVRAQYEEIAQRSKSEAE 373
Query: 266 QTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELE 325
Y KL + ++ + + + + E+ME I+ L +++ N++K++ I E E
Sbjct: 374 ALYQTKLGELQTTAGRHGDDLRNTKSEIMELNRMIQRLRAEIENVKKQNANLQTAIAEAE 433
Query: 326 DLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEE 385
++ L D + + + +D + + L DY++L++VKLALD+EI+ YRKLLEGEE
Sbjct: 434 QRGEMALKDANAKLQDLQTALQKAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEGEE 493
Query: 386 ERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRV--DVEESEASSSVSISHSASATG 440
++S S V +S S+ S + G + V V S + S S+S++G
Sbjct: 494 --CRMSGECQSAVCISVVSNVTSTSGSSGSSRGVFGGVSGSGSGGYKGGSSSSSSSG 548
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 134 bits (338), Expect = 2e-31
Identities = 110/429 (25%), Positives = 193/429 (44%), Gaps = 49/429 (11%)
Query: 15 AGGPTTPLSPTRLSRLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTE-REEVRGR 73
+ GP + SR EKE+L+ LNDR A YIDKVR LE N +L+ + R++ GR
Sbjct: 81 SNGPEGCMVAVATSR-SEKEQLQALNDRFAGYIDKVRQLEAHNRSLEGEAAALRQQQAGR 139
Query: 74 ELTGLKALYETELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQI 133
G LYE E+ + R A+ R +L++E EH
Sbjct: 140 SAMG--ELYEREVREMRGAVLRLGAARGQLRLE-----QEH------------------- 173
Query: 134 KLREYEAALNSKDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVD 193
L D + L+D Q + EA+ A + + +VD
Sbjct: 174 ------------------LLEDIAHVRQRLDDEARQREEAEAAARALARFAQEAEAARVD 215
Query: 194 LENRCQSLTEDLEFRKSMYEEEINETRRKHE---TRLVEVDSGRQIEYEYKLAQALHEMR 250
L+ + Q+L E+ + + ++EE+ E + + ++ + + + + AL E+R
Sbjct: 216 LQKKAQALQEECGYLRRHHQEEVGELLGQIQGSGAAQAQMQAETRDALKCDVTSALREIR 275
Query: 251 EQHDAQVRLYKEELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNL 310
Q + + E+ + +L+ ++++NT + SA+EE+ E R ++++ +++L L
Sbjct: 276 AQLEGHAVQSTLQSEEWFRVRLDRLSEAAKVNTDAMRSAQEEITEYRRQLQARTTELEAL 335
Query: 311 QKESRACLERIQELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLAL 370
+ + + ELED + + + + + E+ + +M QL +Y+ LL+VK+AL
Sbjct: 336 KSTKDSLERQRSELEDRHQADIASYQEAIQQLDAELRNTKWEMAAQLREYQDLLNVKMAL 395
Query: 371 DMEISAYRKLLEGEEERLKLSPSPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSV 430
D+EI+AYRKLLEGEE R+ P P S S S +++ V E +V
Sbjct: 396 DIEIAAYRKLLEGEECRIGFGPIPFSLPEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETV 455
Query: 431 SISHSASAT 439
+ T
Sbjct: 456 IVEEQTEET 464
>gi|119395750 keratin 1 [Homo sapiens]
Length = 644
Score = 134 bits (337), Expect = 2e-31
Identities = 95/387 (24%), Positives = 195/387 (50%), Gaps = 49/387 (12%)
Query: 31 QEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELT-GLKALYETELADA 89
+E+E+++ LN++ A +IDKVR LE +N LQ + ++V T L+ +E+ + +
Sbjct: 179 REREQIKSLNNQFASFIDKVRFLEQQNQVLQTKWELLQQVDTSTRTHNLEPYFESFINNL 238
Query: 90 RRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAAL 149
RR +D ++++L EL + ++ +Y K YE +N + A
Sbjct: 239 RRRVDQLKSDQSRLDSELKNMQ----DMVEDYRNK-------------YEDEINKRTNA- 280
Query: 150 ATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRK 209
E KK + + KVDL+ + +L ++++F
Sbjct: 281 ------------------------ENEFVTIKKDVDGAYMTKVDLQAKLDNLQQEIDFLT 316
Query: 210 SMYEEEINETRRK-HETRLV-EVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQT 267
++Y+ E+++ + + ET ++ +D+ R ++ + +A E++ Q++ + K E E
Sbjct: 317 ALYQAELSQMQTQISETNVILSMDNNRSLDLDSIIA----EVKAQYEDIAQKSKAEAESL 372
Query: 268 YHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDL 327
Y +K E ++++ + +V +++ E+ E I+ L S++ N++K+ + I + E
Sbjct: 373 YQSKYEELQITAGRHGDSVRNSKIEISELNRVIQRLRSEIDNVKKQISNLQQSISDAEQR 432
Query: 328 LAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEER 387
+++ L D E + + ++ + + L DY++L++ KLALD+EI+ YR LLEGEE R
Sbjct: 433 GENALKDAKNKLNDLEDALQQAKEDLARLLRDYQELMNTKLALDLEIATYRTLLEGEESR 492
Query: 388 LKLSPSPSSRVTVSRASSSRSVRTTRG 414
+ +P+ V+VS + ++ S +RG
Sbjct: 493 MSGECAPNVSVSVSTSHTTISGGGSRG 519
>gi|109255249 keratin 4 [Homo sapiens]
Length = 594
Score = 134 bits (336), Expect = 3e-31
Identities = 97/383 (25%), Positives = 186/383 (48%), Gaps = 51/383 (13%)
Query: 29 RLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTE-REEVRGRELTGLKALYETELA 87
R +E+E+++ LN++ A +IDKV+ LE +N L+ + +++ L+ L+ET L+
Sbjct: 208 RTEEREQIKLLNNKFASFIDKVQFLEQQNKVLETKWNLLQQQTTTTSSKNLEPLFETYLS 267
Query: 88 DARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDA 147
R+ LD ++ +LQ EL K D + D +YE +N + A
Sbjct: 268 VLRKQLDTLGNDKGRLQSEL---KTMQDSV--------EDFK------TKYEEEINKRTA 310
Query: 148 ALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEF 207
A E KK + L KV+LE + SL +++ F
Sbjct: 311 A-------------------------ENDFVVLKKDVDAAYLNKVELEAKVDSLNDEINF 345
Query: 208 RKSMYEEEINE--TRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELE 265
K +Y+ E+++ T + ++ +D+ R ++ + +A E+R Q++ + K E E
Sbjct: 346 LKVLYDAELSQMQTHVSDTSVVLSMDNNRNLDLDSIIA----EVRAQYEEIAQRSKAEAE 401
Query: 266 QTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELE 325
Y K++ ++S + + + + + E+ E I+ L +++ N++K+ + + + E
Sbjct: 402 ALYQTKVQQLQISVDQHGDNLKNTKSEIAELNRMIQRLRAEIENIKKQCQTLQVSVADAE 461
Query: 326 DLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEE 385
++ + E + + ++++ + L +Y++L+ VKLALD+EI+ YRKLLEGEE
Sbjct: 462 QRGENALKDAHSKRVELEAALQQAKEELARMLREYQELMSVKLALDIEIATYRKLLEGEE 521
Query: 386 ERLKLSPSPSSRVTVSRASSSRS 408
R +S S V++S S S S
Sbjct: 522 YR--MSGECQSAVSISVVSGSTS 542
>gi|14917119 keratin 34 [Homo sapiens]
Length = 436
Score = 132 bits (331), Expect = 1e-30
Identities = 104/370 (28%), Positives = 186/370 (50%), Gaps = 49/370 (13%)
Query: 32 EKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARR 91
EKE ++ LNDRLA Y++KVR LE +N+ L+ + ER + + E L + +
Sbjct: 98 EKETMQFLNDRLASYLEKVRQLERDNAELEKLIQERSQQQ-----------EPLLCPSYQ 146
Query: 92 ALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALAT 151
+ T E LQ ++ KAE+ +L++N ++ A++ ++ + ++ +
Sbjct: 147 SYFKTIEE---LQQKILCAKAENARLVVN-------IDNAKLASDDFRSKYQTEQSLRLL 196
Query: 152 ALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKSM 211
D S+ L++L TL K DLE++ +SL E+L K
Sbjct: 197 VESDINSIRRILDEL---------------------TLCKSDLESQVESLREELICLKKN 235
Query: 212 YEEEINETRRKHETRL-VEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHA 270
+EEE+N R + RL VEVD+ ++ L Q L+E R Q++A V + + E+EQ +
Sbjct: 236 HEEEVNTLRSQLGDRLNVEVDTAPTVD----LNQVLNETRSQYEALVEINRREVEQWFAT 291
Query: 271 KLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLER-IQELEDLLA 329
+ E ++ + S + E++E R + +L +L Q R LE + E E +
Sbjct: 292 QTEELNKQVVSSSEQLQSCQAEIIELRRTVNALEIELQ-AQHNLRDSLENTLTESEAHYS 350
Query: 330 KEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLK 389
+ + ++T+ E ++AEIR +++Q +Y+ LLDV+ L+ EI+ YR LLE E+ +L
Sbjct: 351 SQLSQVQSLITNVESQLAEIRCDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCKLP 410
Query: 390 LSPSPSSRVT 399
+P ++ +
Sbjct: 411 CNPCATTNAS 420
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 132 bits (331), Expect = 1e-30
Identities = 121/449 (26%), Positives = 207/449 (46%), Gaps = 82/449 (18%)
Query: 29 RLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELAD 88
R QEK +L++LNDR A +I++V LE +N L E EL
Sbjct: 87 RTQEKAQLQDLNDRFASFIERVHELEQQNKVL----------------------EAELLV 124
Query: 89 ARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAA 148
R+ + +R RA + E+ DL A E A N K A
Sbjct: 125 LRQKHSEPSRFRALYEQEI------------------RDLRLAA------EDATNEKQAL 160
Query: 149 LATALGDKKSLEGDLEDLKDQIAQ-------LEASLAAAKKQLADETLLKVDLENRCQSL 201
G+++ LE L +L+ + + E L A+K + L + +LE R SL
Sbjct: 161 Q----GEREGLEETLRNLQARYEEEVLSREDAEGRLMEARKGADEAALARAELEKRIDSL 216
Query: 202 TEDLEFRKSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYK 261
+++ F K ++EEEI E + + + + V+ + L+ AL ++R Q++
Sbjct: 217 MDEISFLKKVHEEEIAELQAQIQYAQISVEMDVT---KPDLSAALKDIRAQYEKLAAKNM 273
Query: 262 EELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERI 321
+ E+ + ++ S+ NT V +A++E+ ESR +++ + ++ + + A +++
Sbjct: 274 QNAEEWFKSRFTVLTESAAKNTDAVRAAKDEVSESRRLLKAKTLEIEACRGMNEALEKQL 333
Query: 322 QELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLL 381
QELED + + + E E+ + +M + L +Y+ LL+VK+ALD+EI+AYRKLL
Sbjct: 334 QELEDKQNADISAMQDTINKLENELRTTKSEMARYLKEYQDLLNVKMALDIEIAAYRKLL 393
Query: 382 EGEEERLKLSP--------SPSSRV----------TVSRASSSR---SVRTTRGKRKRVD 420
EGEE RL + S SS+V T S S+R S T+ + ++++
Sbjct: 394 EGEETRLSFTSVGSITSGYSQSSQVFGRSAYGGLQTSSYLMSTRSFPSYYTSHVQEEQIE 453
Query: 421 VEES-EASSSVSISHSASATGNVCIEEID 448
VEE+ EA+ + + G EE D
Sbjct: 454 VEETIEAAKAEEAKDEPPSEGEAEEEEKD 482
>gi|153791158 keratin 75 [Homo sapiens]
Length = 551
Score = 131 bits (330), Expect = 2e-30
Identities = 98/382 (25%), Positives = 190/382 (49%), Gaps = 52/382 (13%)
Query: 29 RLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELT-GLKALYETELA 87
R +E+E+++ LN++ A +IDKVR LE +N L+ + +E R + L+ L+++ +
Sbjct: 146 RAEEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWALLQEQGSRTVRQNLEPLFDSYTS 205
Query: 88 DARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDA 147
+ RR L+ ER +L+ EL + + K+R YE +N + A
Sbjct: 206 ELRRQLESITTERGRLEAELRNMQDVVEDF----------------KVR-YEDEINKRTA 248
Query: 148 ALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEF 207
A E A KK + + KV+LE + +SL E++ F
Sbjct: 249 A-------------------------ENEFVALKKDVDAAYMNKVELEAKVKSLPEEINF 283
Query: 208 RKSMYEEEINE--TRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELE 265
S+++ E+++ T+ + ++ +D+ R ++ + +A E++ Q++ + E E
Sbjct: 284 IHSVFDAELSQLQTQVGDTSVVLSMDNNRNLDLDSIIA----EVKAQYEDIANRSRAEAE 339
Query: 266 QTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELE 325
Y K E ++++ + + + ++E+ E I+ L +++ +++K+ + I + E
Sbjct: 340 SWYQTKYEELQVTAGRHGDDLRNTKQEISEMNRMIQRLRAEIDSVKKQCSSLQTAIADAE 399
Query: 326 DLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEE 385
++R L D E + + + M + L +Y++L+++KLALD+EI+ YRKLLEGEE
Sbjct: 400 QRGELALKDARAKLVDLEEALQKAKQDMARLLREYQELMNIKLALDVEIATYRKLLEGEE 459
Query: 386 ERLK---LSPSPSSRVTVSRAS 404
RL +SP S VT + +S
Sbjct: 460 CRLSGEGVSPVNISVVTSTLSS 481
>gi|131412225 keratin 13 isoform a [Homo sapiens]
Length = 458
Score = 131 bits (330), Expect = 2e-30
Identities = 108/389 (27%), Positives = 189/389 (48%), Gaps = 56/389 (14%)
Query: 32 EKEELRELNDRLAVYIDKVRSLETENSALQLQVTE--REEVRGRELTGLKALYETELADA 89
EK ++ LNDRLA Y++KVR+LE N+ L++++ + ++ Y+T + +
Sbjct: 104 EKITMQNLNDRLASYLEKVRALEEANADLEVKIRDWHLKQSPASPERDYSPYYKT-IEEL 162
Query: 90 RRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAAL 149
R + E ++ +E+ + D L Y E E AL
Sbjct: 163 RDKILTATIENNRVILEIDNARLAADDFRLKY---------------ENELAL------- 200
Query: 150 ATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRK 209
++S+E D+ L+ + +L TL K DLE + +SL E+L + K
Sbjct: 201 ------RQSVEADINGLRRVLDEL--------------TLSKTDLEMQIESLNEELAYMK 240
Query: 210 SMYEEEINETRRKHETRL-VEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTY 268
+EEE+ E + ++ VE+D+ I+ L + L EMREQ++A + + E+ +
Sbjct: 241 KNHEEEMKEFSNQVVGQVNVEMDATPGID----LTRVLAEMREQYEAMAERNRRDAEEWF 296
Query: 269 HAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLER-IQELEDL 327
HAK NT+ + +++ E+ E R ++ L +L + Q +A LE + E E
Sbjct: 297 HAKSAELNKEVSTNTAMIQTSKTEITELRRTLQGLEIELQS-QLSMKAGLENTVAETECR 355
Query: 328 LAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEER 387
A + + +++ E +++E+R +M+ Q +Y+ LLD+K L+ EI+ YR LLEG++ +
Sbjct: 356 YALQLQQIQGLISSIEAQLSELRSEMECQNQEYKMLLDIKTRLEQEIATYRSLLEGQDAK 415
Query: 388 LKLSPSP----SSRVTVSRASSSRSVRTT 412
+ PS S R T +SS SV TT
Sbjct: 416 MIGFPSSAGSVSPRSTSVTTTSSASVTTT 444
>gi|14917117 keratin 33A [Homo sapiens]
Length = 404
Score = 131 bits (329), Expect = 2e-30
Identities = 105/389 (26%), Positives = 182/389 (46%), Gaps = 51/389 (13%)
Query: 32 EKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARR 91
EKE ++ LNDRLA Y++KVR LE +N+ L+ + ER + + + Y + + ++
Sbjct: 56 EKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLVCASYQSYFKTIEELQQ 115
Query: 92 ALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALAT 151
+ + E A+L +++ K D Y T
Sbjct: 116 KILCSKSENARLVVQIDNAKLASDDFRTKY----------------------------ET 147
Query: 152 ALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKSM 211
L ++ +E D+ L+ + +L TL + DLE + +SL E+L K
Sbjct: 148 ELSLRQLVESDINGLRRILDEL--------------TLCRSDLEAQVESLKEELLCLKQN 193
Query: 212 YEEEINETRRKHETRL-VEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHA 270
+E+E+N R + RL VEVD+ ++ L Q L+E R Q++A V + E+EQ +
Sbjct: 194 HEQEVNTLRCQLGDRLNVEVDAAPTVD----LNQVLNETRSQYEALVETNRREVEQWFAT 249
Query: 271 KLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLER-IQELEDLLA 329
+ E ++ + S + E++E R + +L +L Q R LE + E E +
Sbjct: 250 QTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIEL-QAQHNLRDSLENTLTESEARYS 308
Query: 330 KEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLK 389
+ +R++T+ E ++AEIR +++Q +Y+ LLDV+ L+ EI+ YR LLE E+ K
Sbjct: 309 SQLSQVQRLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLLESED--CK 366
Query: 390 LSPSPSSRVTVSRASSSRSVRTTRGKRKR 418
L +P + S+ + G R R
Sbjct: 367 LPSNPCATTNACDKSTGPCISNPCGLRAR 395
>gi|109148552 keratin 3 [Homo sapiens]
Length = 628
Score = 130 bits (328), Expect = 3e-30
Identities = 99/391 (25%), Positives = 192/391 (49%), Gaps = 53/391 (13%)
Query: 29 RLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTG---LKALYETE 85
+ QE+E+++ LN++ A +IDKVR LE +N L+ + ++ ++G L+ L+E
Sbjct: 195 KAQEREQIKTLNNKFASFIDKVRFLEQQNKVLETKWNLLQQQGTSSISGTNNLEPLFENH 254
Query: 86 LADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSK 145
+ R LD+ ER +L EL + L+ ++ KK YE +N +
Sbjct: 255 INYLRSYLDNILGERGRLDSELKNM----EDLVEDFKKK-------------YEDEINKR 297
Query: 146 DAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDL 205
AA E KK + + KV+L+ + +L +++
Sbjct: 298 TAA-------------------------ENEFVTLKKDVDSAYMNKVELQAKVDALIDEI 332
Query: 206 EFRKSMYEEEINETRRK-HETRLV-EVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEE 263
+F +++Y+ E+++ + +T +V +D+ R ++ + +A E+R Q++ + K E
Sbjct: 333 DFLRTLYDAELSQMQSHISDTSVVLSMDNNRSLDLDSIIA----EVRAQYEDIAQRSKAE 388
Query: 264 LEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQE 323
E Y KL + ++ + + + + E++E I+ L +++ ++K++ I E
Sbjct: 389 AEALYQTKLGELQTTAGRHGDDLRNTKSEIIELNRMIQRLRAEIEGVKKQNANLQTAIAE 448
Query: 324 LEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEG 383
E ++ L + + + + +D + + L DY++L++VKLALD+EI+ YRKLLEG
Sbjct: 449 AEQHGEMALKDANAKLQELQAALQQAKDDLARLLRDYQELMNVKLALDVEIATYRKLLEG 508
Query: 384 EEERLKLSPSPSSRVTVSRASSSRSVRTTRG 414
EE R +S S V++S SSS + + G
Sbjct: 509 EEYR--MSGECPSAVSISVVSSSTTSASAGG 537
>gi|14917115 keratin 31 [Homo sapiens]
Length = 416
Score = 130 bits (326), Expect = 4e-30
Identities = 102/363 (28%), Positives = 174/363 (47%), Gaps = 49/363 (13%)
Query: 32 EKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARR 91
EKE ++ LNDRLA Y++KVR LE +N+ L+ + ER + + L Y + + ++
Sbjct: 56 EKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQ 115
Query: 92 ALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALAT 151
+ T E A+L +++ K D Y T
Sbjct: 116 KILCTKSENARLVVQIDNAKLAADDFRTKY----------------------------QT 147
Query: 152 ALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKSM 211
L ++ +E D+ L+ + +L TL K DLE + +SL E+L KS
Sbjct: 148 ELSLRQLVESDINGLRRILDEL--------------TLCKSDLEAQVESLKEELLCLKSN 193
Query: 212 YEEEINETRRKHETRL-VEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHA 270
+E+E+N R + RL VEVD+ ++ L + L+E R Q++A V + E+EQ +
Sbjct: 194 HEQEVNTLRCQLGDRLNVEVDAAPTVD----LNRVLNETRSQYEALVETNRREVEQWFTT 249
Query: 271 KLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLER-IQELEDLLA 329
+ E ++ + S + E++E R + +L +L Q R LE + E E +
Sbjct: 250 QTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIEL-QAQHNLRDSLENTLTESEARYS 308
Query: 330 KEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLK 389
+ + ++T+ E ++AEIR +++Q +Y+ LLDV+ L+ EI+ YR LLE E+ L
Sbjct: 309 SQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCNLP 368
Query: 390 LSP 392
+P
Sbjct: 369 SNP 371
>gi|148612803 keratin 6 irs4 [Homo sapiens]
Length = 529
Score = 129 bits (325), Expect = 6e-30
Identities = 99/384 (25%), Positives = 189/384 (49%), Gaps = 57/384 (14%)
Query: 29 RLQEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTG----LKALYET 84
R QE+E+++ LND+ A +IDKVR LE +N L+ T+ E ++ +L L+ + E
Sbjct: 137 RAQEREQIKVLNDKFASFIDKVRFLEQQNQVLE---TKWELLQQLDLNNCKKNLEPILEG 193
Query: 85 ELADARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNS 144
+++ R+ L+ + +R +L EL + L+ +Y K+ YE +N
Sbjct: 194 YISNLRKQLETLSGDRVRLDSELRSMR----DLVEDYKKR-------------YEVEINR 236
Query: 145 KDAALATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTED 204
+ A E KK +KV+L+ + SL ++
Sbjct: 237 RTTA-------------------------ENEFVVLKKDADAAYAVKVELQAKVDSLDKE 271
Query: 205 LEFRKSMYEEEINE--TRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKE 262
++F K +Y+ EI + T + ++ +D+ R ++ + +A E+R ++ K
Sbjct: 272 IKFLKCLYDAEIAQIQTHASETSVILSMDNNRDLDLDSIIA----EVRMHYEEIALKSKA 327
Query: 263 ELEQTYHAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQ 322
E E Y K++ +L++ + + R E++E I+ + ++ N++K+ + I
Sbjct: 328 EAEALYQTKIQELQLAASRHGDDLKHTRSEMVELNRLIQRIRCEIGNVKKQRASLETAIA 387
Query: 323 ELEDLLAKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLE 382
+ E +++ L + E + + ++++ + L +Y++L+ +KLALDMEI+ YRKLLE
Sbjct: 388 DAEQRGDNALKDAQAKLDELEGALHQAKEELARMLREYQELMSLKLALDMEIATYRKLLE 447
Query: 383 GEEERLKLSPSPSSRVTVSRASSS 406
GEE R+ +PSS V++S SSS
Sbjct: 448 GEECRMS-GENPSS-VSISVISSS 469
>gi|15431318 keratin 38 [Homo sapiens]
Length = 456
Score = 129 bits (325), Expect = 6e-30
Identities = 107/378 (28%), Positives = 186/378 (49%), Gaps = 49/378 (12%)
Query: 32 EKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARR 91
EKE ++ LNDRLA Y++KVR LE EN+ L+ + ER + +E+ + +
Sbjct: 104 EKETMQFLNDRLANYLEKVRQLEQENAELEATLLERSKC-----------HESTVCPDYQ 152
Query: 92 ALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALAT 151
+ T E LQ ++ KAE+ +L++ ++ A++ ++ L S
Sbjct: 153 SYFHTIEE---LQQKILCSKAENARLIVQ-------IDNAKLAADDFRIKLES------- 195
Query: 152 ALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKSM 211
E L L +EA +K L D TL K DLE + +SL E+ KS
Sbjct: 196 --------ERSLRQL------VEADKCGTQKLLDDATLAKADLEAQQESLKEEQLSLKSN 241
Query: 212 YEEEINETRRKHETRL-VEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHA 270
+E+E+ R + +L +E+D IE L + L EMR Q++A + ++++EQ + A
Sbjct: 242 HEQEVKILRSQLGEKLRIELD----IEPTIDLNRVLGEMRAQYEAMLETNRQDVEQWFQA 297
Query: 271 KLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLER-IQELEDLLA 329
+ E L + + + E++E R + +L + Q + CL+ + E ED
Sbjct: 298 QSEGISLQDMSCSEELQCCQSEILELRCTVNALEVE-RQAQHTLKDCLQNSLCEAEDRFG 356
Query: 330 KEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLK 389
E + ++++ E +++EIR +++Q +Y+ LLDVK L+ EI+ YR LLE E+ +L
Sbjct: 357 TELAQMQSLISNVEEQLSEIRADLERQNQEYQVLLDVKTRLENEIATYRNLLESEDCKLP 416
Query: 390 LSPSPSSRVTVSRASSSR 407
+P +S V+ + R
Sbjct: 417 CNPCSTSPSCVTAPCAPR 434
>gi|10337581 type I hair keratin 3B [Homo sapiens]
Length = 404
Score = 128 bits (322), Expect = 1e-29
Identities = 101/363 (27%), Positives = 176/363 (48%), Gaps = 49/363 (13%)
Query: 32 EKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRELTGLKALYETELADARR 91
EKE ++ LNDRLA Y++KVR LE +N+ L+ + ER + + L Y + + ++
Sbjct: 56 EKETMQFLNDRLASYLEKVRQLERDNAELENLIRERSQQQEPLLCPSYQSYFKTIEELQQ 115
Query: 92 ALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALAT 151
+ + E A+L +++ K D Y ++S LR+
Sbjct: 116 KILCSKSENARLVVQIDNAKLAADDFRTKYQTEQS--------LRQL------------- 154
Query: 152 ALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKSM 211
+E D+ L+ + +L TL + DLE + +SL E+L K
Sbjct: 155 -------VESDINSLRRILDEL--------------TLCRSDLEAQMESLKEELLSLKQN 193
Query: 212 YEEEINETRRKHETRL-VEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYHA 270
+E+E+N R + RL VEVD+ ++ L Q L+E R Q++A V + E+EQ +
Sbjct: 194 HEQEVNTLRCQLGDRLNVEVDAAPAVD----LNQVLNETRNQYEALVETNRREVEQWFAT 249
Query: 271 KLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLER-IQELEDLLA 329
+ E ++ + S + E++E R + +L +L Q R LE + E E +
Sbjct: 250 QTEELNKQVVSSSEQLQSYQAEIIELRRTVNALEIEL-QAQHNLRYSLENTLTESEARYS 308
Query: 330 KEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERLK 389
+ + ++T+ E ++AEIR +++Q +Y+ LLDV+ L+ EI+ YR LLE E+ +L
Sbjct: 309 SQLSQVQSLITNVESQLAEIRSDLERQNQEYQVLLDVRARLECEINTYRSLLESEDCKLP 368
Query: 390 LSP 392
+P
Sbjct: 369 SNP 371
>gi|125628636 keratin 80 isoform a [Homo sapiens]
Length = 452
Score = 128 bits (321), Expect = 2e-29
Identities = 108/389 (27%), Positives = 180/389 (46%), Gaps = 52/389 (13%)
Query: 31 QEKEELRELNDRLAVYIDKVRSLETENSALQLQVTEREEVRGRE--LTGLKALYETELAD 88
QEKEE++ LND+ A I KV++LE N L+ T ++G++ + L LYE
Sbjct: 82 QEKEEMKALNDKFASLIGKVQALEQRNQLLE---TRWSFLQGQDSAIFDLGHLYE----- 133
Query: 89 ARRALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAA 148
+ +LQ EL K E QL E++L K+ E+
Sbjct: 134 ---------EYQGRLQEELRKVSQERGQL-------EANLLQVLEKVEEFRIRY------ 171
Query: 149 LATALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFR 208
ED + +E + KK L E L + +LE + +SL +E
Sbjct: 172 ---------------EDEISKRTDMEFTFVQLKKDLDAECLHRTELETKLKSLESFVELM 216
Query: 209 KSMYEEEINETRRKHETRLVEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTY 268
K++YE+E+ + + + V V G L+ + E++ Q+DA EE E
Sbjct: 217 KTIYEQELKDLAA--QVKDVSVTVGMDSRCHIDLSGIVEEVKAQYDAVAARSLEEAEAYS 274
Query: 269 HAKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLERIQELEDLL 328
++LE S S++ S+R E+ + +RI+ L SQ+ +++ E I+ E+
Sbjct: 275 RSQLEEQAARSAEYGSSLQSSRSEIADLNVRIQKLRSQILSVKSHCLKLEENIKTAEEQG 334
Query: 329 AKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERL 388
+++ L E + + + M +QL Y++L++VKLALD+EI+ YRKL+EGEE R+
Sbjct: 335 ELAFQDAKTKLAQLEAALQQAKQDMARQLRKYQELMNVKLALDIEIATYRKLVEGEEGRM 394
Query: 389 KLSPSPSSRVTVSRASSSRSVRTTRGKRK 417
SPS+ V + S ++ + G K
Sbjct: 395 ---DSPSATVVSAVQSRCKTAASRSGLSK 420
>gi|24430192 keratin 16 [Homo sapiens]
Length = 473
Score = 128 bits (321), Expect = 2e-29
Identities = 110/411 (26%), Positives = 198/411 (48%), Gaps = 60/411 (14%)
Query: 32 EKEELRELNDRLAVYIDKVRSLETENSALQLQVTE-REEVRGRELTGLKALYETELADAR 90
EK ++ LNDRLA Y+DKVR+LE N+ L++++ + + R E+ ++T + D R
Sbjct: 117 EKVTMQNLNDRLASYLDKVRALEEANADLEVKIRDWYQRQRPSEIKDYSPYFKT-IEDLR 175
Query: 91 RALDDTARERAKLQIELGKCKAEHDQLLLNYAKKESDLNGAQIKLREYEAALNSKDAALA 150
+ E A+ +++ + D Y E+E AL
Sbjct: 176 NKIIAATIENAQPILQIDNARLAADDFRTKY---------------EHELAL-------- 212
Query: 151 TALGDKKSLEGDLEDLKDQIAQLEASLAAAKKQLADETLLKVDLENRCQSLTEDLEFRKS 210
++++E D+ L+ + +L TL + DLE + + L E+L + +
Sbjct: 213 -----RQTVEADVNGLRRVLDEL--------------TLARTDLEMQIEGLKEELAYLRK 253
Query: 211 MYEEEINETRRKHETRL-VEVDSGRQIEYEYKLAQALHEMREQHDAQVRLYKEELEQTYH 269
+EEE+ R + + VE+D+ ++ L++ L+EMR+Q++ + + E +
Sbjct: 254 NHEEEMLALRGQTGGDVNVEMDAAPGVD----LSRILNEMRDQYEQMAEKNRRDAETWFL 309
Query: 270 AKLENARLSSEMNTSTVNSAREELMESRMRIESLSSQLSNLQKESRACLER-IQELEDLL 328
+K E N+ V S+R E+ E R ++ L +L + Q +A LE ++E +
Sbjct: 310 SKTEELNKEVASNSELVQSSRSEVTELRRVLQGLEIELQS-QLSMKASLENSLEETKGRY 368
Query: 329 AKEKDNSRRMLTDKEREMAEIRDQMQQQLNDYEQLLDVKLALDMEISAYRKLLEGEEERL 388
+ + ++ E ++A++R +M+QQ +Y+ LLDVK L+ EI+ YR+LLEGE+ L
Sbjct: 369 CMQLSQIQGLIGSVEEQLAQLRCEMEQQSQEYQILLDVKTRLEQEIATYRRLLEGEDAHL 428
Query: 389 ---KLSPSPSSRVTVSRASSSRSVRTTRGKRKRVDVEESEASSSVSISHSA 436
+ S S V +SSS S R TR + + ++SSS S S+
Sbjct: 429 SSQQASGQSYSSREVFTSSSSSSSRQTR------PILKEQSSSSFSQGQSS 473
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.309 0.125 0.328
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,070,702
Number of Sequences: 37866
Number of extensions: 883332
Number of successful extensions: 10784
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 292
Number of HSP's successfully gapped in prelim test: 873
Number of HSP's that attempted gapping in prelim test: 6082
Number of HSP's gapped (non-prelim): 3241
length of query: 586
length of database: 18,247,518
effective HSP length: 108
effective length of query: 478
effective length of database: 14,157,990
effective search space: 6767519220
effective search space used: 6767519220
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.