Guide to the Human Genome
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Name: SMAD4 Sequence: fasta or formatted (552aa) NCBI GI: 4885457
Description:

mothers against decapentaplegic homolog 4

Referenced in:

TGF-beta Family

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             8.7         48           5
 C cysteine            2.5         14           1
 D aspartate           4.7         26           2
 E glutamate           4.5         25           1
 F phenylalanine       2.4         13           1
 G glycine             7.2         40           2
 H histidine           5.4         30           2
 I isoleucine          5.3         29           1
 K lysine              3.6         20           2
 L leucine             7.4         41           2
 M methionine          1.8         10           2
 N asparagine          3.4         19           1
 P proline             8.2         45           2
 Q glutamine           5.8         32           3
 R arginine            4.3         24           2
 S serine              8.2         45           2
 T threonine           5.8         32           3
 V valine              6.0         33           2
 W tryptophan          1.4          8           1
 Y tyrosine            3.3         18           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   mothers against decapentaplegic homolog 4 
SMAD9                 0.222   SMAD family member 9 isoform a 
SMAD3                 0.219   mothers against decapentaplegic homolog 3 isoform 1 [...
SMAD5                 0.215   SMAD, mothers against DPP homolog 5 
SMAD5                 0.215   SMAD, mothers against DPP homolog 5 
SMAD5                 0.215   SMAD, mothers against DPP homolog 5 
SMAD1                 0.213   Sma- and Mad-related protein 1 
SMAD1                 0.213   Sma- and Mad-related protein 1 
SMAD9                 0.187   SMAD family member 9 isoform b 
SMAD3                 0.160   mothers against decapentaplegic homolog 3 isoform 3...
SMAD3                 0.137   mothers against decapentaplegic homolog 3 isoform 2...
SMAD3                 0.129   mothers against decapentaplegic homolog 3 isoform 4...
SMAD2                 0.127   Sma- and Mad-related protein 2 isoform 1 
SMAD2                 0.127   Sma- and Mad-related protein 2 isoform 1 
SMAD2                 0.127   Sma- and Mad-related protein 2 isoform 2 
SMAD6                 0.066   SMAD family member 6 isoform 2 
SMAD6                 0.066   SMAD family member 6 isoform 1 
SMAD7                 0.056   SMAD family member 7 
POU3F3                0.016   POU class 3 homeobox 3 
ASXL2                 0.015   additional sex combs like 2 
FOXJ3                 0.015   forkhead box J3 
ARHGEF5               0.012   rho guanine nucleotide exchange factor 5 
ARID1A                0.011   AT rich interactive domain 1A isoform a 
ARID1A                0.011   AT rich interactive domain 1A isoform b 
NCAN                  0.011   chondroitin sulfate proteoglycan 3 
LOC727832             0.010   golgi autoantigen, golgin subfamily a-like 
LOC283767             0.010   golgi autoantigen, golgin subfamily a-like 
MUC6                  0.010   mucin 6, gastric 
SHANK1                0.010   SH3 and multiple ankyrin repeat domains 1 
RLIM                  0.009   ring finger protein, LIM domain interacting 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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