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Search of human proteins with 4826958
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826958 ATP-binding cassette, sub-family D, member 4 [Homo
sapiens]
(606 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826958 ATP-binding cassette, sub-family D, member 4 [Homo sa... 1210 0.0
gi|4506341 ATP-binding cassette, sub-family D, member 3 isoform ... 253 5e-67
gi|7262393 ATP-binding cassette, sub-family D (ALD), member 1 [H... 226 6e-59
gi|9945308 ATP-binding cassette, sub-family D, member 2 [Homo sa... 222 7e-58
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 73 7e-13
gi|169881286 ATP-binding cassette, sub-family D, member 3 isofor... 71 3e-12
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 67 6e-11
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 65 2e-10
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 64 4e-10
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 64 5e-10
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 62 1e-09
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 62 2e-09
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 62 2e-09
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 62 2e-09
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 62 2e-09
gi|90421313 cystic fibrosis transmembrane conductance regulator ... 61 3e-09
gi|157502203 ATP-binding cassette, sub-family C, member 4 isofor... 61 3e-09
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 61 3e-09
gi|21729876 ATP-binding cassette, sub-family C, member 11 isofor... 60 8e-09
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 60 8e-09
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 60 8e-09
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 59 2e-08
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 57 6e-08
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 56 8e-08
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 56 1e-07
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 55 2e-07
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 55 2e-07
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 55 2e-07
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 55 2e-07
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 54 3e-07
>gi|4826958 ATP-binding cassette, sub-family D, member 4 [Homo
sapiens]
Length = 606
Score = 1210 bits (3131), Expect = 0.0
Identities = 606/606 (100%), Positives = 606/606 (100%)
Query: 1 MAVAGPAPGAGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQV 60
MAVAGPAPGAGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQV
Sbjct: 1 MAVAGPAPGAGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQV 60
Query: 61 GLIPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLH 120
GLIPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLH
Sbjct: 61 GLIPSQYYGVLGNKDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLH 120
Query: 121 RLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQ 180
RLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQ
Sbjct: 121 RLYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQ 180
Query: 181 STGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYR 240
STGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYR
Sbjct: 181 STGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYR 240
Query: 241 AGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGD 300
AGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGD
Sbjct: 241 AGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGD 300
Query: 301 LSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQD 360
LSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQD
Sbjct: 301 LSPAELSTLVSKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQD 360
Query: 361 CEILGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLIT 420
CEILGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLIT
Sbjct: 361 CEILGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLIT 420
Query: 421 GNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKE 480
GNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKE
Sbjct: 421 GNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKE 480
Query: 481 VYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYL 540
VYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYL
Sbjct: 481 VYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYL 540
Query: 541 QPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWEL 600
QPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWEL
Sbjct: 541 QPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWEL 600
Query: 601 MRIKVE 606
MRIKVE
Sbjct: 601 MRIKVE 606
>gi|4506341 ATP-binding cassette, sub-family D, member 3 isoform a
[Homo sapiens]
Length = 659
Score = 253 bits (645), Expect = 5e-67
Identities = 181/616 (29%), Positives = 312/616 (50%), Gaps = 38/616 (6%)
Query: 9 GAGARPRLDLQFLQRFLQILKVLFPSWSSQNA----LMFLTLLCLTLLEQFVIYQVGLIP 64
G R +D F R +QILK++ P + L+ + L+ T + ++I LI
Sbjct: 52 GKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIE 111
Query: 65 SQYYGVLGN--KDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHRL 122
S G++G KD + + L F+A M ++ S + +F ++ N L + +R LT++L+
Sbjct: 112 S---GIIGRSRKDFKRY-LLNFIAAMPLI--SLVNNFLKYGLNELKLCFRVRLTKYLYEE 165
Query: 123 YFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQST 182
Y + YY + L + I NPDQ ++QDVE+FC + + S L +V Y ++ +
Sbjct: 166 YLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAI 225
Query: 183 GWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEKLEGDFRFKHMQIRVNAEPAAFYRAG 242
G GP S+ Y ++ + L PI + ++K EG++R+ + ++ N+E AFY
Sbjct: 226 GAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGN 285
Query: 243 HVEHMRTDRRLQRLLQTQRELMSKELWL-YIGINTFDYLGSILSYVVIAIPIFSGVYGDL 301
E ++L++ + + +I YL +++ Y+V++ P DL
Sbjct: 286 KREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFL-----DL 340
Query: 302 S-PAELSTLVS-------KNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLD 353
S P L + S ++ + + + +++ ++ +AG+T RI +L + L D
Sbjct: 341 SHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKD 400
Query: 354 MSLKSQDCEILGESEWGLD------TPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDL 407
++ + ++ + E G++ PG AD + V ++ P+ D LI+DL
Sbjct: 401 LNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGD-VLIRDL 459
Query: 408 SLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTD 467
+ ++ G ++LI G G GK+SL RVLG LW G LT + ++PQ+P+ T
Sbjct: 460 NFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGG---RLTKPERGKLFYVPQRPYMTL 516
Query: 468 GTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPG 527
GTLR+QVIYP D + +L+ L +++ R G D D W DVLS G
Sbjct: 517 GTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQD--WMDVLSGG 574
Query: 528 EMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHRQSLEKFHS 587
E QR++ ARLFY +P++A+LDE TSA++ +VE +Y +++G+T +V HR+SL K H
Sbjct: 575 EKQRMAMARLFYHKPQFAILDECTSAVSVDVEGYIYSHCRKVGITLFTVSHRKSLWKHHE 634
Query: 588 LVLKLCGGGRWELMRI 603
L + G G +E +I
Sbjct: 635 YYLHMDGRGNYEFKQI 650
>gi|7262393 ATP-binding cassette, sub-family D (ALD), member 1 [Homo
sapiens]
Length = 745
Score = 226 bits (575), Expect = 6e-59
Identities = 178/638 (27%), Positives = 302/638 (47%), Gaps = 58/638 (9%)
Query: 10 AGARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGLIPSQYYG 69
A A+ ++ FLQR L +L++LFP + + + F+ V + +
Sbjct: 61 AAAKAGMNRVFLQRLLWLLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLAR 120
Query: 70 VLGNKDLEGFKTLTFLAVMLIVLNST-LKSFDQFTCNLLYVSWRKDLTEHLHRLYFRGRA 128
+ KD F L +LI L +T + S ++ L +S+R L H +RLYF +
Sbjct: 121 CIVRKDPRAFGW-QLLQWLLIALPATFVNSAIRYLEGQLALSFRSRLVAHAYRLYFSQQT 179
Query: 129 YYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLI-------ISPFTLVYYTYQCFQS 181
YY ++ + + NPDQ +++DV F ++ + S L ++ +TL+
Sbjct: 180 YYRVSNMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAG 239
Query: 182 TGWLGPVSIFGYFILGTVVNKTLMGPIVMKLVHQE-KLEGDFRFKHMQIRVNAEPAAFYR 240
T W P +I G + T P +LV +E + +G+ R+ H ++ N+E AFY
Sbjct: 240 TAW--PSAIAGLVVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYG 297
Query: 241 AGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTF--DYLGSILSYVVIAIPIFSGVY 298
VE R Q L ++ + LW Y+ + F Y+ S +++A+PI +
Sbjct: 298 GHEVELALLQRSYQDLASQINLILLERLW-YVMLEQFLMKYVWSASGLLMVAVPIITATG 356
Query: 299 GDLSPAEL---STLVSKNAFVCIYLISCFTQLIDLSTTLSD--------------VAGYT 341
S AE + L K + FT +L T +D +AGYT
Sbjct: 357 YSESDAEAVKKAALEKKEEELVSERTEAFTIARNLLTAAADAIERIMSSYKEVTELAGYT 416
Query: 342 HRIGQLRETLLDMSLKSQDCEI-----LGESEWGLDT--PPGWPAAEP---------ADT 385
R+ ++ + D+ Q C L +++ G T G P +
Sbjct: 417 ARVHEMFQVFEDV----QRCHFKRPRELEDAQAGSGTIGRSGVRVEGPLKIRGQVVDVEQ 472
Query: 386 AFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV 445
+ E + I PS + ++ L++++ EG LLITG G GK+SL R+LGGLW + G
Sbjct: 473 GIICENIPIVTPSGEV-VVASLNIRVEEGMHLLITGPNGCGKSSLFRILGGLWPTYGG-- 529
Query: 446 QMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNL 505
+L P + ++PQ+P+ + G+LR+QVIYP ++ + L++ L ++
Sbjct: 530 -VLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDSVEDMQRKGYSEQDLEAILDVVHLHHI 588
Query: 506 VARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRI 565
+ R G + DW DVLS GE QR+ AR+FY +PKYA+LDE TSA++ +VE ++++
Sbjct: 589 LQREGGWEAMCDWK--DVLSGGEKQRIGMARMFYHRPKYALLDECTSAVSIDVEGKIFQA 646
Query: 566 GQQLGMTFISVGHRQSLEKFHSLVLKLCGGGRWELMRI 603
+ G+ +S+ HR SL K+H+ +L+ G G W+ ++
Sbjct: 647 AKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKL 684
>gi|9945308 ATP-binding cassette, sub-family D, member 2 [Homo
sapiens]
Length = 740
Score = 222 bits (566), Expect = 7e-58
Identities = 177/630 (28%), Positives = 298/630 (47%), Gaps = 49/630 (7%)
Query: 6 PAPGAGARPRLDLQFLQRFLQILKVLFPSW-SSQNALMFLTLLCLTLLEQFVIYQVGLIP 64
P+PG A F ++ L++ K+LFP +++ + L + L IY GL
Sbjct: 76 PSPGVNA------DFFKQLLELRKILFPKLVTTETGWLCLHSVALISRTFLSIYVAGLDG 129
Query: 65 SQYYGVLGNKDLEGFKTLT---FLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHR 121
++ K L +A+ +NS ++ + C L +++R L +H +
Sbjct: 130 KIVKSIVEKKPRTFIIKLIKWLMIAIPATFVNSAIRYLE---CKLA-LAFRTRLVDHAYE 185
Query: 122 LYFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKL---IISPFTLVYYTYQC 178
YF + YY + + + NPDQ +++D+ F + ++ + S L I+ Y Q
Sbjct: 186 TYFTNQTYYKVINMDGRLANPDQSLTEDIMMFSQSVAHLYSNLTKPILDVMLTSYTLIQT 245
Query: 179 FQSTGW--LGPVSIFGYFILGTVVNKTLMGPIVMKLVHQEK-LEGDFRFKHMQIRVNAEP 235
S G +GP + G + T P KLV +E +G R+ H +I N E
Sbjct: 246 ATSRGASPIGPTLLAGLVVYATAKVLKACSPKFGKLVAEEAHRKGYLRYVHSRIIANVEE 305
Query: 236 AAFYRAGHVEHMRTDRRLQRLLQTQRELMSKELWLYIGINTF--DYLGSILSYVVIAIPI 293
AFYR VE + + + L ++SK LW YI I F Y+ S +++AIPI
Sbjct: 306 IAFYRGHKVEMKQLQKSYKALADQMNLILSKRLW-YIMIEQFLMKYVWSSSGLIMVAIPI 364
Query: 294 FSGV-YGDLSPAELSTLVSKN--AFVCIYLI-----SCFTQLIDLSTTLSDVAGYTHRI- 344
+ + D + +VS+ AF + +++ ++++AGYT R+
Sbjct: 365 ITATGFADGEDGQKQVMVSERTEAFTTARNLLASGADAIERIMSSYKEVTELAGYTARVY 424
Query: 345 ------GQLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEPA-----DTAFLLERVS 393
+++ + + Q+ E ++ ++ P A D + E V
Sbjct: 425 NMFWVFDEVKRGIYKRTAVIQESESHSKNGAKVELPLSDTLAIKGKVIDVDHGIICENVP 484
Query: 394 ISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGP 453
I P+ + + L+ K+ EG LLITG G GK+SL R+L GLW G +L P
Sbjct: 485 IITPAGEV-VASRLNFKVEEGMHLLITGPNGCGKSSLFRILSGLWPVYEG---VLYKPPP 540
Query: 454 HGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLD 513
+ ++PQ+P+ + G+LR+QVIYP D+ + R L L ++V R G D
Sbjct: 541 QHMFYIPQRPYMSLGSLRDQVIYPDSVDDMHDKGYTDQDLERILHNVHLYHIVQREGGWD 600
Query: 514 QQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTF 573
+DW DVLS GE QR+ AR+FY +PKYA+LDE TSA++ +VE ++++ + G++
Sbjct: 601 AVMDWK--DVLSGGEKQRMGMARMFYHKPKYALLDECTSAVSIDVEGKIFQAAKGAGISL 658
Query: 574 ISVGHRQSLEKFHSLVLKLCGGGRWELMRI 603
+S+ HR SL K+H+ +L+ G G W ++
Sbjct: 659 LSITHRPSLWKYHTHLLQFDGEGGWRFEQL 688
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 73.2 bits (178), Expect = 7e-13
Identities = 59/229 (25%), Positives = 108/229 (47%), Gaps = 23/229 (10%)
Query: 375 PGWPAAEPADTAFLLERVSISAPSS-DKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRV 433
PG A + VS + P+ D+P++K L+ + G+ + G G+GK+++ +
Sbjct: 456 PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAAL 515
Query: 434 LGGLWTSTRGSVQMLTDFGPHG----------VLFLPQKPFFTDGTLREQVIYPLKEVYP 483
L L+ T G Q+L D P V+ + Q+P G++R + Y L+
Sbjct: 516 LQNLYQPTGG--QVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQ---- 569
Query: 484 DSGSADDERILRFLELAGLSNLVARTE-GLDQQVDWNWYDVLSPGEMQRLSFARLFYLQP 542
S +D++++ + A + + E G+ V L+ G+ QRL+ AR P
Sbjct: 570 ---SCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ-LAAGQKQRLAIARALVRDP 625
Query: 543 KYAVLDEATSALTEEVESELYRIGQQLGMTFISVGHR-QSLEKFHSLVL 590
+ +LDEATSAL + E L + T + + HR Q++++ H +++
Sbjct: 626 RVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQAVQRAHQILV 674
>gi|169881286 ATP-binding cassette, sub-family D, member 3 isoform b
[Homo sapiens]
Length = 236
Score = 71.2 bits (173), Expect = 3e-12
Identities = 53/181 (29%), Positives = 92/181 (50%), Gaps = 12/181 (6%)
Query: 9 GAGARPRLDLQFLQRFLQILKVLFPSWSSQNA----LMFLTLLCLTLLEQFVIYQVGLIP 64
G R +D F R +QILK++ P + L+ + L+ T + ++I LI
Sbjct: 52 GKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIE 111
Query: 65 SQYYGVLGN--KDLEGFKTLTFLAVMLIVLNSTLKSFDQFTCNLLYVSWRKDLTEHLHRL 122
S G++G KD + + L F+A M ++ S + +F ++ N L + +R LT++L+
Sbjct: 112 S---GIIGRSRKDFKRY-LLNFIAAMPLI--SLVNNFLKYGLNELKLCFRVRLTKYLYEE 165
Query: 123 YFRGRAYYTLNVLRDDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQST 182
Y + YY + L + I NPDQ ++QDVE+FC + + S L +V Y ++ +
Sbjct: 166 YLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAI 225
Query: 183 G 183
G
Sbjct: 226 G 226
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 66.6 bits (161), Expect = 6e-11
Identities = 68/244 (27%), Positives = 109/244 (44%), Gaps = 27/244 (11%)
Query: 366 ESEW---GLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGN 422
E+ W G P GWP + S+ +++DLSL + G+ + I G
Sbjct: 1269 EAPWVVEGSRPPEGWPPRGEVE----FRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGR 1324
Query: 423 TGTGKTSLLRVLGGLWTSTRGSVQM----LTDFGPHG----VLFLPQKPFFTDGTLREQV 474
TG GK+S+ L + + +G +++ + D G H + +PQ P GTLR +
Sbjct: 1325 TGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNL 1384
Query: 475 IYPLKEVYPDSGSADDERILRFLELAGLSNLV-ARTEGLDQQVDWNWYDVLSPGEMQRLS 533
GS +E I LEL+ L V ++ GLD Q + LS G+ Q +
Sbjct: 1385 --------DPFGSYSEEDIWWALELSHLHTFVSSQPAGLDFQCS-EGGENLSVGQRQLVC 1435
Query: 534 FARLFYLQPKYAVLDEATSALTEEVESELY-RIGQQLG-MTFISVGHRQSLEKFHSLVLK 591
AR + + VLDEAT+A+ E ++ + I Q T +++ HR + ++ VL
Sbjct: 1436 LARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLV 1495
Query: 592 LCGG 595
L G
Sbjct: 1496 LDKG 1499
Score = 61.2 bits (147), Expect = 3e-09
Identities = 134/597 (22%), Positives = 243/597 (40%), Gaps = 70/597 (11%)
Query: 11 GARPRLDLQFLQRFLQILKVLFPSWSSQNALMFLTLLCLTLLEQFVIYQVGLIPSQYYGV 70
GARPR R LK L ++ S FL C L++ + + + S
Sbjct: 289 GARPR------PRKPSFLKALLATFGSS----FLISACFKLIQDLLSFINPQLLSILIRF 338
Query: 71 LGNKDLEGFKTLTFLAVMLIVLNSTLKSFD-QFTCNLLYVSWRKDLTEHLHRLYFRGRAY 129
+ N + FL L+ L S ++S Q + ++V+ K T + +Y R
Sbjct: 339 ISNPMAPSW--WGFLVAGLMFLCSMMQSLILQHYYHYIFVTGVKFRTGIMGVIY-RKALV 395
Query: 130 YTLNVLR-DDIDNPDQRISQDVERFCRQLSSMASKLIISPFTLVYYTYQCFQSTGWLGPV 188
T +V R + +S D +RF L+ + L +P ++ Y +Q+ LGP
Sbjct: 396 ITNSVKRASTVGEIVNLMSVDAQRFM-DLAPFLNLLWSAPLQIILAIYFLWQN---LGPS 451
Query: 189 SIFGYFILGTVVNKTLMGPIVMKL----VHQEKLEGDFRFKHMQIRVNAEPAAFYRAGHV 244
+ G + ++ L G + +K+ V Q KL+ D R K M +N A
Sbjct: 452 VLAGVAFMVLLI--PLNGAVAVKMRAFQVKQMKLK-DSRIKLMSEILNGIKVLKLYAWEP 508
Query: 245 EHMRTDRRLQRLLQTQRELMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPA 304
++ +++ + Q + +L+ +L+ TF ++ S ++V I ++ VY D +
Sbjct: 509 SFLK---QVEGIRQGELQLLRTAAYLHT-TTTFTWMCS--PFLVTLITLWVYVYVDPN-- 560
Query: 305 ELSTLVSKNAFVCIYLISCFTQLID-LSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEI 363
+ L ++ AFV + L + ++ L +S++ + + ++++ L L Q E
Sbjct: 561 --NVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEELDPQSVER 618
Query: 364 LGESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNT 423
S PG+ A + + + P + L +++ +G + + G
Sbjct: 619 KTIS-------PGY--------AITIHSGTFTWAQDLPPTLHSLDIQVPKGALVAVVGPV 663
Query: 424 GTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYP 483
G GK+SL+ L G G V M V ++PQ+ + + TL+E V++
Sbjct: 664 GCGKSSLVSALLGEMEKLEGKVHM-----KGSVAYVPQQAWIQNCTLQENVLF------- 711
Query: 484 DSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPK 543
+ + +R + LE L + G DQ LS G+ QR+S AR Y
Sbjct: 712 -GKALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDAD 770
Query: 544 YAVLDEATSALTEEVESELYR--IGQQ---LGMTFISVGHRQSLEKFHSLVLKLCGG 595
+LD+ SA+ V ++ IG + G T + V H S ++ L G
Sbjct: 771 IFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADG 827
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 65.1 bits (157), Expect = 2e-10
Identities = 53/197 (26%), Positives = 92/197 (46%), Gaps = 22/197 (11%)
Query: 375 PGWPAAEPADTAFLLERVSISAPSS-DKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRV 433
PG A + VS + P+ D+P++K L+ + G+ + G G+GK+++ +
Sbjct: 456 PGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAAL 515
Query: 434 LGGLWTSTRGSVQMLTDFGPHG----------VLFLPQKPFFTDGTLREQVIYPLKEVYP 483
L L+ T G Q+L D P V+ + Q+P G++R + Y L+
Sbjct: 516 LQNLYQPTGG--QVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQ---- 569
Query: 484 DSGSADDERILRFLELAGLSNLVARTE-GLDQQVDWNWYDVLSPGEMQRLSFARLFYLQP 542
S +D++++ + A + + E G+ V L+ G+ QRL+ AR P
Sbjct: 570 ---SCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQ-LAAGQKQRLAIARALVRDP 625
Query: 543 KYAVLDEATSALTEEVE 559
+ +LDEATSAL + E
Sbjct: 626 RVLILDEATSALDVQCE 642
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 63.9 bits (154), Expect = 4e-10
Identities = 54/209 (25%), Positives = 99/209 (47%), Gaps = 27/209 (12%)
Query: 403 LIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV--------QMLTDFGPH 454
+++ LSL I G+++ G++G GK++ +++L L+ +G V ++ +
Sbjct: 587 ILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRS 646
Query: 455 GVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERIL---RFLELAGLSNLVARTEG 511
+ +PQ+P + ++ E + Y D+ R++ E A +N+ + EG
Sbjct: 647 QIAIVPQEPVLFNCSIAENIAY-----------GDNSRVVPLDEIKEAANAANIHSFIEG 695
Query: 512 LDQQVDWNWY---DVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRI--G 566
L ++ + LS G+ QRL+ AR +PK +LDEATSAL + E +
Sbjct: 696 LPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDK 755
Query: 567 QQLGMTFISVGHRQSLEKFHSLVLKLCGG 595
+ G T + V HR S + L++ L G
Sbjct: 756 ARTGRTCLVVTHRLSAIQNADLIVVLHNG 784
Score = 44.3 bits (103), Expect = 3e-04
Identities = 28/74 (37%), Positives = 40/74 (54%), Gaps = 2/74 (2%)
Query: 524 LSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQL--GMTFISVGHRQS 581
+S G+ QR++ AR PK +LDEATSAL E +S + ++ G T I V HR S
Sbjct: 80 MSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAALEKASKGRTTIVVAHRLS 139
Query: 582 LEKFHSLVLKLCGG 595
+ L++ L G
Sbjct: 140 TIRSADLIVTLKDG 153
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 63.5 bits (153), Expect = 5e-10
Identities = 57/209 (27%), Positives = 98/209 (46%), Gaps = 21/209 (10%)
Query: 400 DKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV--------QMLTDF 451
D P+++ LSL++ +GQ+L + G++G GK++++++L + G V ++ +
Sbjct: 1049 DIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQW 1108
Query: 452 GPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEG 511
+ + Q+P D ++ E + Y +S E I+R A +N+ A E
Sbjct: 1109 LRAHLGIVSQEPILFDCSIAENIAYG-----DNSRVVSQEEIVR---AAKEANIHAFIES 1160
Query: 512 LDQQVDWNWYD---VLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQ 568
L + D LS G+ QR++ AR QP +LDEATSAL E E + +
Sbjct: 1161 LPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDK 1220
Query: 569 L--GMTFISVGHRQSLEKFHSLVLKLCGG 595
G T I + HR S + L++ G
Sbjct: 1221 AREGRTCIVIAHRLSTIQNADLIVVFQNG 1249
Score = 62.8 bits (151), Expect = 9e-10
Identities = 57/201 (28%), Positives = 94/201 (46%), Gaps = 18/201 (8%)
Query: 392 VSISAPS-SDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQM-LT 449
V S PS + ++K L+LK+ GQ++ + GN+G GK++ ++++ L+ T G V +
Sbjct: 397 VHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQ 456
Query: 450 DFGPHGVLFL-------PQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGL 502
D V FL Q+P T+ E + Y + V D I + ++ A
Sbjct: 457 DIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMD-------EIEKAVKEANA 509
Query: 503 SNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVES-- 560
+ + + + LS G+ QR++ AR PK +LDEATSAL E E+
Sbjct: 510 YDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV 569
Query: 561 ELYRIGQQLGMTFISVGHRQS 581
++ + G T I + HR S
Sbjct: 570 QVALDKARKGRTTIVIAHRLS 590
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 62.4 bits (150), Expect = 1e-09
Identities = 57/205 (27%), Positives = 92/205 (44%), Gaps = 16/205 (7%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQM----LTDFGP---- 453
P+ +D SL I G + G +G+GK+++L +L L+ G++ + + P
Sbjct: 508 PIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLR 567
Query: 454 HGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVAR-TEGL 512
+ + Q+P ++ E + Y D S E I R E+A + +G
Sbjct: 568 SKIGTVSQEPILFSCSIAENIAYGAD----DPSSVTAEEIQRVAEVANAVAFIRNFPQGF 623
Query: 513 DQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQL--G 570
+ V +LS G+ QR++ AR PK +LDEATSAL E E + +L G
Sbjct: 624 NTVVGEKGV-LLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDG 682
Query: 571 MTFISVGHRQSLEKFHSLVLKLCGG 595
T + + HR S K ++V L G
Sbjct: 683 RTVLVIAHRLSTIKNANMVAVLDQG 707
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 62.0 bits (149), Expect = 2e-09
Identities = 57/209 (27%), Positives = 88/209 (42%), Gaps = 20/209 (9%)
Query: 403 LIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQM----LTDFGPHG--- 455
++KD +L + G+ + + G +G GKT++ +L + T G V + L P
Sbjct: 472 VLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSWLRG 531
Query: 456 --VLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVAR-TEGL 512
V F+ Q+P T+ E + + E A DE + A + EG
Sbjct: 532 QVVGFISQEPVLFGTTIMENIRFGKLE-------ASDEEVYTAAREANAHEFITSFPEGY 584
Query: 513 DQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRI--GQQLG 570
+ V LS G+ QRL+ AR QP +LDEATSAL E E + G
Sbjct: 585 NTVVGERG-TTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAG 643
Query: 571 MTFISVGHRQSLEKFHSLVLKLCGGGRWE 599
T + + HR S + ++ + G WE
Sbjct: 644 RTVLVIAHRLSTVRGAHCIVVMADGRVWE 672
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 62.0 bits (149), Expect = 2e-09
Identities = 53/201 (26%), Positives = 94/201 (46%), Gaps = 18/201 (8%)
Query: 392 VSISAPS-SDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQML-T 449
V S PS ++ ++K L+LK+ GQ++ + G++G GK++ ++++ L+ G++ +
Sbjct: 399 VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQ 458
Query: 450 DFGPHGVLFL-------PQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGL 502
D V +L Q+P T+ E + Y G+ + I + ++ A
Sbjct: 459 DIRNFNVNYLREIIGVVSQEPVLFSTTIAENICY-------GRGNVTMDEIKKAVKEANA 511
Query: 503 SNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESEL 562
+ + + LS G+ QR++ AR PK +LDEATSAL E E+E+
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 563 YRIGQQL--GMTFISVGHRQS 581
+ G T I + HR S
Sbjct: 572 QAALDKAREGRTTIVIAHRLS 592
Score = 61.2 bits (147), Expect = 3e-09
Identities = 56/219 (25%), Positives = 99/219 (45%), Gaps = 38/219 (17%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPH------- 454
P+++ LSL++ +GQ+L + G++G GK++++++L + G+V DFG
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTV--FVDFGFQLLDGQEA 1107
Query: 455 ----------GVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERIL---RFLELAG 501
+ + Q+P D ++ E + Y D+ R++ + A
Sbjct: 1108 KKLNVQWLRAQLGIVSQEPILFDCSIAENIAY-----------GDNSRVVSQDEIVSAAK 1156
Query: 502 LSNLVARTEGLDQQVDWNWYDV---LSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEV 558
+N+ E L + + D LS G+ QR++ AR QP+ +LDEATSAL E
Sbjct: 1157 AANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTES 1216
Query: 559 ESELYRIGQQL--GMTFISVGHRQSLEKFHSLVLKLCGG 595
E + + G T I + HR S + L++ G
Sbjct: 1217 EKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1255
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 62.0 bits (149), Expect = 2e-09
Identities = 53/201 (26%), Positives = 94/201 (46%), Gaps = 18/201 (8%)
Query: 392 VSISAPS-SDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQML-T 449
V S PS ++ ++K L+LK+ GQ++ + G++G GK++ ++++ L+ G++ +
Sbjct: 399 VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQ 458
Query: 450 DFGPHGVLFL-------PQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGL 502
D V +L Q+P T+ E + Y G+ + I + ++ A
Sbjct: 459 DIRNFNVNYLREIIGVVSQEPVLFSTTIAENICY-------GRGNVTMDEIKKAVKEANA 511
Query: 503 SNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESEL 562
+ + + LS G+ QR++ AR PK +LDEATSAL E E+E+
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 563 YRIGQQL--GMTFISVGHRQS 581
+ G T I + HR S
Sbjct: 572 QAALDKAREGRTTIVIAHRLS 592
Score = 61.6 bits (148), Expect = 2e-09
Identities = 53/210 (25%), Positives = 99/210 (47%), Gaps = 27/210 (12%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV--------QMLTDFGP 453
P+++ LSL++ +GQ+L + G++G GK++++++L + G+V ++ +
Sbjct: 1003 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1062
Query: 454 HGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERIL---RFLELAGLSNLVARTE 510
+ + Q+P D ++ E + Y D+ R++ + A +N+ E
Sbjct: 1063 AQLGIVSQEPILFDCSIAENIAY-----------GDNSRVVSQDEIVSAAKAANIHPFIE 1111
Query: 511 GLDQQVDWNWYDV---LSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQ 567
L + + D LS G+ QR++ AR QP+ +LDEATSAL E E +
Sbjct: 1112 TLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALD 1171
Query: 568 QL--GMTFISVGHRQSLEKFHSLVLKLCGG 595
+ G T I + HR S + L++ G
Sbjct: 1172 KAREGRTCIVIAHRLSTIQNADLIVVFQNG 1201
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 62.0 bits (149), Expect = 2e-09
Identities = 53/201 (26%), Positives = 94/201 (46%), Gaps = 18/201 (8%)
Query: 392 VSISAPS-SDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQML-T 449
V S PS ++ ++K L+LK+ GQ++ + G++G GK++ ++++ L+ G++ +
Sbjct: 399 VHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQ 458
Query: 450 DFGPHGVLFL-------PQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGL 502
D V +L Q+P T+ E + Y G+ + I + ++ A
Sbjct: 459 DIRNFNVNYLREIIGVVSQEPVLFSTTIAENICY-------GRGNVTMDEIKKAVKEANA 511
Query: 503 SNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESEL 562
+ + + LS G+ QR++ AR PK +LDEATSAL E E+E+
Sbjct: 512 YEFIMKLPQKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEV 571
Query: 563 YRIGQQL--GMTFISVGHRQS 581
+ G T I + HR S
Sbjct: 572 QAALDKAREGRTTIVIAHRLS 592
Score = 61.6 bits (148), Expect = 2e-09
Identities = 53/210 (25%), Positives = 99/210 (47%), Gaps = 27/210 (12%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV--------QMLTDFGP 453
P+++ LSL++ +GQ+L + G++G GK++++++L + G+V ++ +
Sbjct: 1050 PVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLR 1109
Query: 454 HGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERIL---RFLELAGLSNLVARTE 510
+ + Q+P D ++ E + Y D+ R++ + A +N+ E
Sbjct: 1110 AQLGIVSQEPILFDCSIAENIAY-----------GDNSRVVSQDEIVSAAKAANIHPFIE 1158
Query: 511 GLDQQVDWNWYDV---LSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQ 567
L + + D LS G+ QR++ AR QP+ +LDEATSAL E E +
Sbjct: 1159 TLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALD 1218
Query: 568 QL--GMTFISVGHRQSLEKFHSLVLKLCGG 595
+ G T I + HR S + L++ G
Sbjct: 1219 KAREGRTCIVIAHRLSTIQNADLIVVFQNG 1248
>gi|90421313 cystic fibrosis transmembrane conductance regulator
[Homo sapiens]
Length = 1480
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/162 (27%), Positives = 73/162 (45%), Gaps = 13/162 (8%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQ 461
P++KD++ KI GQ L + G+TG GKTSLL V+ G + G ++ + F Q
Sbjct: 439 PVLKDINFKIERGQLLAVAGSTGAGKTSLLMVIMGELEPSEGKIK-----HSGRISFCSQ 493
Query: 462 KPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWY 521
+ GT++E +I+ + S D+ R ++ L +++ D V
Sbjct: 494 FSWIMPGTIKENIIFGV--------SYDEYRYRSVIKACQLEEDISKFAEKDNIVLGEGG 545
Query: 522 DVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELY 563
LS G+ R+S AR Y +LD L E E++
Sbjct: 546 ITLSGGQRARISLARAVYKDADLYLLDSPFGYLDVLTEKEIF 587
Score = 43.5 bits (101), Expect = 6e-04
Identities = 44/165 (26%), Positives = 75/165 (45%), Gaps = 27/165 (16%)
Query: 403 LIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQM-------------LT 449
+++++S IS GQ + + G TG+GK++LL L +T G +Q+
Sbjct: 1226 ILENISFSISPGQRVGLLGRTGSGKSTLLSAFLRL-LNTEGEIQIDGVSWDSITLQQWRK 1284
Query: 450 DFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVART 509
FG +PQK F GT R+ + P ++ D+ I + + GL +++ +
Sbjct: 1285 AFG-----VIPQKVFIFSGTFRKN-LDPYEQ-------WSDQEIWKVADEVGLRSVIEQF 1331
Query: 510 EGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSAL 554
G V + VLS G Q + AR + K +LDE ++ L
Sbjct: 1332 PGKLDFVLVDGGCVLSHGHKQLMCLARSVLSKAKILLLDEPSAHL 1376
>gi|157502203 ATP-binding cassette, sub-family C, member 4 isoform 2
[Homo sapiens]
Length = 859
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/169 (26%), Positives = 78/169 (46%), Gaps = 15/169 (8%)
Query: 398 SSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHG-V 456
+S+ P ++ LS + G+ L + G G GK+SLL + G + G V + HG +
Sbjct: 422 ASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSV------HGRI 475
Query: 457 LFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQV 516
++ Q+P+ GTLR +++ K + ER + ++ L + E D V
Sbjct: 476 AYVSQQPWVFSGTLRSNILFGKK--------YEKERYEKVIKACALKKDLQLLEDGDLTV 527
Query: 517 DWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRI 565
+ LS G+ R++ AR Y +LD+ SA+ EV L+ +
Sbjct: 528 IGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFEL 576
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 61.2 bits (147), Expect = 3e-09
Identities = 45/169 (26%), Positives = 78/169 (46%), Gaps = 15/169 (8%)
Query: 398 SSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHG-V 456
+S+ P ++ LS + G+ L + G G GK+SLL + G + G V + HG +
Sbjct: 422 ASETPTLQGLSFTVRPGELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSV------HGRI 475
Query: 457 LFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQV 516
++ Q+P+ GTLR +++ K + ER + ++ L + E D V
Sbjct: 476 AYVSQQPWVFSGTLRSNILFGKK--------YEKERYEKVIKACALKKDLQLLEDGDLTV 527
Query: 517 DWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRI 565
+ LS G+ R++ AR Y +LD+ SA+ EV L+ +
Sbjct: 528 IGDRGTTLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVSRHLFEL 576
Score = 45.4 bits (106), Expect = 1e-04
Identities = 51/228 (22%), Positives = 96/228 (42%), Gaps = 29/228 (12%)
Query: 366 ESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGT 425
E+ W P P A P + + + V+ ++K L+ I + + I G TG
Sbjct: 1022 EAPWEYQKRP--PPAWPHEGVIIFDNVNFMYSPGGPLVLKHLTALIKSQEKVGIVGRTGA 1079
Query: 426 GKTSLLRVL-------GGLWTSTRGSVQMLTDFGPHG----VLFLPQKPFFTDGTLREQV 474
GK+SL+ L G +W + T+ G H + +PQ+P GT+R+
Sbjct: 1080 GKSSLISALFRLSEPEGKIWIDK----ILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKN- 1134
Query: 475 IYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEG-LDQQVDWNWYDVLSPGEMQRLS 533
+ P E DE + L+ L + G +D ++ + + S G+ Q +
Sbjct: 1135 LDPFNE-------HTDEELWNALQEVQLKETIEDLPGKMDTELAESGSN-FSVGQRQLVC 1186
Query: 534 FARLFYLQPKYAVLDEATSALTEEVESELY-RIGQQLG-MTFISVGHR 579
AR + + ++DEAT+ + + + +I ++ T +++ HR
Sbjct: 1187 LARAILRKNQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHR 1234
>gi|21729876 ATP-binding cassette, sub-family C, member 11 isoform b
[Homo sapiens]
Length = 1344
Score = 59.7 bits (143), Expect = 8e-09
Identities = 63/213 (29%), Positives = 98/213 (46%), Gaps = 24/213 (11%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVL-FLP 460
P + ++L +S+G L + GNTG+GK+SLL + GSV G G L ++P
Sbjct: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSV------GVQGSLAYVP 578
Query: 461 QKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNW 520
Q+ + G +RE ++ G+ D R L+ L L+ + D
Sbjct: 579 QQAWIVSGNIRENILM--------GGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGER 630
Query: 521 YDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYR--IGQQL-GMTFISVG 577
LS G+ QR+S AR Y + +LD+ SA+ V ++ I + L G T + V
Sbjct: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
Query: 578 HR-QSLEKFHSLVL----KLC-GGGRWELMRIK 604
H+ Q LE ++L K+C G ELM+ K
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKK 723
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 59.7 bits (143), Expect = 8e-09
Identities = 63/213 (29%), Positives = 98/213 (46%), Gaps = 24/213 (11%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVL-FLP 460
P + ++L +S+G L + GNTG+GK+SLL + GSV G G L ++P
Sbjct: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSV------GVQGSLAYVP 578
Query: 461 QKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNW 520
Q+ + G +RE ++ G+ D R L+ L L+ + D
Sbjct: 579 QQAWIVSGNIRENILM--------GGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGER 630
Query: 521 YDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYR--IGQQL-GMTFISVG 577
LS G+ QR+S AR Y + +LD+ SA+ V ++ I + L G T + V
Sbjct: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
Query: 578 HR-QSLEKFHSLVL----KLC-GGGRWELMRIK 604
H+ Q LE ++L K+C G ELM+ K
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKK 723
Score = 41.2 bits (95), Expect = 0.003
Identities = 61/252 (24%), Positives = 104/252 (41%), Gaps = 31/252 (12%)
Query: 370 GLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTS 429
G P GWP + + + + ++ ++L I + + I G TG+GK+S
Sbjct: 1128 GTSCPQGWPQ----HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSS 1183
Query: 430 LLRVLGGLWTSTRGSVQM---------LTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKE 480
L L L G + + L D + +PQ P GT+R +
Sbjct: 1184 LGMALFRLVEPMAGRILIDGVDICSIGLEDLRSK-LSVIPQDPVLLSGTIRFNL------ 1236
Query: 481 VYPDSGSADDERILRFLELAGLSNLVAR-TEGLDQQVDWNWYDVLSPGEMQRLSFARLFY 539
D++I LE L+ +++ + L V N + S GE Q L AR
Sbjct: 1237 --DPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGN-FSVGERQLLCIARAVL 1293
Query: 540 LQPKYAVLDEATSALTEEVESELYRIGQQL--GMTFISVGHRQS--LEKFHSLVL---KL 592
K ++DEAT+++ E ++ + R ++ G T + + HR + L H LV+ K+
Sbjct: 1294 RNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKV 1353
Query: 593 CGGGRWELMRIK 604
R E++R K
Sbjct: 1354 VEFDRPEVLRKK 1365
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 59.7 bits (143), Expect = 8e-09
Identities = 63/213 (29%), Positives = 98/213 (46%), Gaps = 24/213 (11%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVL-FLP 460
P + ++L +S+G L + GNTG+GK+SLL + GSV G G L ++P
Sbjct: 525 PELHKINLVVSKGMMLGVCGNTGSGKSSLLSAILEEMHLLEGSV------GVQGSLAYVP 578
Query: 461 QKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNW 520
Q+ + G +RE ++ G+ D R L+ L L+ + D
Sbjct: 579 QQAWIVSGNIRENILM--------GGAYDKARYLQVLHCCSLNRDLELLPFGDMTEIGER 630
Query: 521 YDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYR--IGQQL-GMTFISVG 577
LS G+ QR+S AR Y + +LD+ SA+ V ++ I + L G T + V
Sbjct: 631 GLNLSGGQKQRISLARAVYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVT 690
Query: 578 HR-QSLEKFHSLVL----KLC-GGGRWELMRIK 604
H+ Q LE ++L K+C G ELM+ K
Sbjct: 691 HQLQYLEFCGQIILLENGKICENGTHSELMQKK 723
Score = 41.2 bits (95), Expect = 0.003
Identities = 61/252 (24%), Positives = 104/252 (41%), Gaps = 31/252 (12%)
Query: 370 GLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTS 429
G P GWP + + + + ++ ++L I + + I G TG+GK+S
Sbjct: 1128 GTSCPQGWPQ----HGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSS 1183
Query: 430 LLRVLGGLWTSTRGSVQM---------LTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKE 480
L L L G + + L D + +PQ P GT+R +
Sbjct: 1184 LGMALFRLVEPMAGRILIDGVDICSIGLEDLRSK-LSVIPQDPVLLSGTIRFNL------ 1236
Query: 481 VYPDSGSADDERILRFLELAGLSNLVAR-TEGLDQQVDWNWYDVLSPGEMQRLSFARLFY 539
D++I LE L+ +++ + L V N + S GE Q L AR
Sbjct: 1237 --DPFDRHTDQQIWDALERTFLTKAISKFPKKLHTDVVENGGN-FSVGERQLLCIARAVL 1293
Query: 540 LQPKYAVLDEATSALTEEVESELYRIGQQL--GMTFISVGHRQS--LEKFHSLVL---KL 592
K ++DEAT+++ E ++ + R ++ G T + + HR + L H LV+ K+
Sbjct: 1294 RNSKIILIDEATASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKV 1353
Query: 593 CGGGRWELMRIK 604
R E++R K
Sbjct: 1354 VEFDRPEVLRKK 1365
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 58.5 bits (140), Expect = 2e-08
Identities = 54/195 (27%), Positives = 87/195 (44%), Gaps = 23/195 (11%)
Query: 403 LIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV----QMLTDFG----PH 454
++ +S ++ G+ + I G +G+GK++++R+L + +GS+ Q + D
Sbjct: 488 VLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRR 547
Query: 455 GVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVAR-TEGLD 513
V +PQ T+ ++Y + SA E + +LAGL + + R G D
Sbjct: 548 AVGVVPQDAVLFHNTIYYNLLY-------GNISASPEEVYAVAKLAGLHDAILRMPHGYD 600
Query: 514 QQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQLGMTF 573
QV LS GE QR++ AR P + DEATS+L E + LG
Sbjct: 601 TQVGERGLK-LSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETI------LGAMK 653
Query: 574 ISVGHRQSLEKFHSL 588
V HR S+ H L
Sbjct: 654 DVVKHRTSIFIAHRL 668
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 56.6 bits (135), Expect = 6e-08
Identities = 50/192 (26%), Positives = 87/192 (45%), Gaps = 15/192 (7%)
Query: 400 DKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV--------QMLTDF 451
D ++ LS+ IS GQ+L G++G GK++ +++L + +G V ++ F
Sbjct: 1092 DSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNVQF 1151
Query: 452 GPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEG 511
+ + Q+P ++ + + Y ++ ER++ + A L + V
Sbjct: 1152 LRSNIGIVSQEPVLFACSIMDNIKYG-----DNTKEIPMERVIAAAKQAQLHDFVMSLPE 1206
Query: 512 LDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVES--ELYRIGQQL 569
+ + LS GE QR++ AR PK +LDEATSAL E E ++ +
Sbjct: 1207 KYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKARE 1266
Query: 570 GMTFISVGHRQS 581
G T I + HR S
Sbjct: 1267 GRTCIVIAHRLS 1278
Score = 55.1 bits (131), Expect = 2e-07
Identities = 52/196 (26%), Positives = 88/196 (44%), Gaps = 31/196 (15%)
Query: 403 LIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRG------------SVQMLTD 450
++ DL++ I G+ + G +G GK++ L+++ + G ++Q L D
Sbjct: 437 ILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRD 496
Query: 451 FGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTE 510
+ + Q+P T+ E + Y ++ A E I++ + A N +
Sbjct: 497 ----QIGIVEQEPVLFSTTIAENIRYGRED-------ATMEDIVQAAKEANAYNFIM--- 542
Query: 511 GLDQQVDW---NWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQ 567
L QQ D +S G+ QR++ AR PK +LD ATSAL E E+ + +
Sbjct: 543 DLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLS 602
Query: 568 QL--GMTFISVGHRQS 581
++ G T ISV HR S
Sbjct: 603 KIQHGHTIISVAHRLS 618
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 56.2 bits (134), Expect = 8e-08
Identities = 55/200 (27%), Positives = 87/200 (43%), Gaps = 19/200 (9%)
Query: 411 ISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV--------QMLTDFGPHGVLFLPQK 462
+ G+ L I G TG+GK+SLL VL L + G V Q+ + +PQ+
Sbjct: 1242 VQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQE 1301
Query: 463 PFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYD 522
PF GT+RE + G D + + L+ LS ++ GLD ++
Sbjct: 1302 PFLFSGTVRENL--------DPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGRS 1353
Query: 523 VLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYR--IGQQLGMTFISVGHRQ 580
LS G+ Q L AR K +DEAT+++ ++ + L + + T +++ HR
Sbjct: 1354 -LSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRL 1412
Query: 581 SLEKFHSLVLKLCGGGRWEL 600
+ VL L G EL
Sbjct: 1413 NTILNSDRVLVLQAGRVVEL 1432
Score = 46.2 bits (108), Expect = 9e-05
Identities = 63/247 (25%), Positives = 107/247 (43%), Gaps = 28/247 (11%)
Query: 358 SQDCEILG-ESEWGLDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLS-LKISEGQ 415
S DC LG + +W L + P AEP+ T L S L +S L++ +G
Sbjct: 544 SPDCGRLGAQIKWLLCSDP---PAEPS-TVLELHGALFSWDPVGTSLETFISHLEVKKGM 599
Query: 416 SLLITGNTGTGKTSLLRVLGGLWTSTRGSVQ---MLTDFGPHGVLFLPQKPFFTDGTLRE 472
+ I G G GK+SLL + G RG V + FG Q+P+ T+R+
Sbjct: 600 LVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFG-----LATQEPWIQFATIRD 654
Query: 473 QVIYPLKEVYPDSGSADDERILR-FLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQR 531
+++ G D ++ + LE L++ ++ DQ LS G+ R
Sbjct: 655 NILF---------GKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRAR 705
Query: 532 LSFARLFYLQPKYAVLDEATSALTEEVESELYR---IGQQLGMTFISVGHR-QSLEKFHS 587
++ AR Y + + +LD+ +A+ +V + L +G T + HR + LE+ +
Sbjct: 706 IALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADA 765
Query: 588 LVLKLCG 594
++L G
Sbjct: 766 VLLMEAG 772
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 55.8 bits (133), Expect = 1e-07
Identities = 61/231 (26%), Positives = 98/231 (42%), Gaps = 26/231 (11%)
Query: 362 EILGESEWGLDT--PPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLI 419
++ E+ W D PP WP+ R P D +++ ++ I + + +
Sbjct: 1277 KVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYR---PELDL-VLRGITCDIGSMEKIGV 1332
Query: 420 TGNTGTGKTSLLRVLGGLWTSTRGSVQM----LTDFGPHGV----LFLPQKPFFTDGTLR 471
G TG GK+SL L + + G + + + G H + +PQ P G+LR
Sbjct: 1333 VGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLR 1392
Query: 472 EQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTE-GLDQQVDWNWYDVLSPGEMQ 530
+ + DE I + LELA L + VA + GL +V + LS G+ Q
Sbjct: 1393 MNL--------DPFNNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGN-LSIGQRQ 1443
Query: 531 RLSFARLFYLQPKYAVLDEATSALTEEVESELYRIGQQ--LGMTFISVGHR 579
L R + K VLDEAT+A+ E ++ + Q T I++ HR
Sbjct: 1444 LLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHR 1494
Score = 52.0 bits (123), Expect = 2e-06
Identities = 40/180 (22%), Positives = 78/180 (43%), Gaps = 13/180 (7%)
Query: 384 DTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRG 443
D A S + + ++D++L I GQ + + G G+GK+SL+ + G + G
Sbjct: 634 DKAMQFSEASFTWEHDSEATVRDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMENVHG 693
Query: 444 SVQMLTDFGPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLS 503
+ + ++PQ+ + +GT+++ +++ +++R + LE L
Sbjct: 694 HITI-----KGTTAYVPQQSWIQNGTIKDNILF--------GTEFNEKRYQQVLEACALL 740
Query: 504 NLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELY 563
+ G D LS G+ QR+S AR Y +LD+ SA+ V ++
Sbjct: 741 PDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVGKHIF 800
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 55.1 bits (131), Expect = 2e-07
Identities = 71/327 (21%), Positives = 127/327 (38%), Gaps = 38/327 (11%)
Query: 263 LMSKELWLYIGINTFDYLGSILSYVVIAIPIFSGVYGDLSPAELSTLVSKNAFVCIYLIS 322
L + WL + + +Y+G+ + + I + ++ +LS + ++ V YL
Sbjct: 1240 LTAANRWLEVRM---EYIGACVVLIAAVTSISNSLHRELSAGLVGLGLTYALMVSNYLNW 1296
Query: 323 CFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWGLDTPPGWPAAEP 382
L D+ L G RI L +T ES GL P P P
Sbjct: 1297 MVRNLADMELQL----GAVKRIHGLLKTE-------------AESYEGLLAPSLIPKNWP 1339
Query: 383 ADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTR 442
++ +S+ SS KP++K ++ I+ GQ + I G TG+GK+S + +
Sbjct: 1340 DQGKIQIQNLSVRYDSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
Query: 443 GSVQM----LTDFGPH----GVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERIL 494
G + + + H + + Q P GT+R + D +
Sbjct: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNL--------DPERKCSDSTLW 1451
Query: 495 RFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSAL 554
LE+A L +V G + + S G+ Q AR F + ++DEAT+++
Sbjct: 1452 EALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASI 1511
Query: 555 TEEVESELYRIGQQ--LGMTFISVGHR 579
E+ L ++ T +++ HR
Sbjct: 1512 DMATENILQKVVMTAFADRTVVTIAHR 1538
Score = 47.8 bits (112), Expect = 3e-05
Identities = 45/186 (24%), Positives = 74/186 (39%), Gaps = 29/186 (15%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLL--------RVLGGLWTSTRGSVQMLTDFGP 453
P + +++++I GQ +I G G GK+SLL +V G ++ S+ ++ D P
Sbjct: 694 PTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSP 753
Query: 454 H-------------GVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELA 500
V + QKP+ + T+ E +I+ + +R +E
Sbjct: 754 ERETATDLDIRKRGPVAYASQKPWLLNATVEENIIF--------ESPFNKQRYKMVIEAC 805
Query: 501 GLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVES 560
L + DQ LS G+ QR+S AR Y LD+ SAL +
Sbjct: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
Query: 561 ELYRIG 566
L + G
Sbjct: 866 HLMQAG 871
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 55.1 bits (131), Expect = 2e-07
Identities = 43/160 (26%), Positives = 72/160 (45%), Gaps = 13/160 (8%)
Query: 404 IKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQKP 463
+ + L+I EG+ + I G+ G+GKTSL+ + G T GS+ + F ++ Q+
Sbjct: 578 LHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISGTFA-----YVAQQA 632
Query: 464 FFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDV 523
+ + TLR+ +++ D+ER L L +A D
Sbjct: 633 WILNATLRDNILF--------GKEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGERGAN 684
Query: 524 LSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELY 563
LS G+ QR+S AR Y +LD+ SAL V + ++
Sbjct: 685 LSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIF 724
Score = 48.1 bits (113), Expect = 2e-05
Identities = 55/216 (25%), Positives = 94/216 (43%), Gaps = 24/216 (11%)
Query: 375 PGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSLLRVL 434
P WP + + F E + + ++K +S I + + I G TG+GK+SL L
Sbjct: 1185 PDWP--QEGEVTF--ENAEMRYRENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMAL 1240
Query: 435 GGLWTSTRGSVQM----LTDFG----PHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSG 486
L + G +++ ++D G + +PQ+P GT+R + P + D
Sbjct: 1241 FRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSN-LDPFNQYTED-- 1297
Query: 487 SADDERILRFLELAGLSNLVARTE-GLDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYA 545
+I LE + +A+ L+ +V N D S GE Q L AR K
Sbjct: 1298 -----QIWDALERTHMKECIAQLPLKLESEVMENG-DNFSVGERQLLCIARALLRHCKIL 1351
Query: 546 VLDEATSALTEEVESELYRIGQQ--LGMTFISVGHR 579
+LDEAT+A+ E + + ++ T +++ HR
Sbjct: 1352 ILDEATAAMDTETDLLIQETIREAFADCTMLTIAHR 1387
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 54.7 bits (130), Expect = 2e-07
Identities = 64/295 (21%), Positives = 122/295 (41%), Gaps = 25/295 (8%)
Query: 311 SKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWG 370
S + V + L+ T L+ + ++A ++G +++ ++++S++ E G
Sbjct: 1207 SNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYE-------G 1259
Query: 371 LDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSL 430
P P P + + + + ++ KP++K + I GQ + I G TG+GK+SL
Sbjct: 1260 TMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSL 1319
Query: 431 LRVLGGLWTSTRGSVQM----LTDFGPH----GVLFLPQKPFFTDGTLREQVIYPLKEVY 482
+ G + + ++ H + + Q P G++R + K
Sbjct: 1320 SLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK--- 1376
Query: 483 PDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQP 542
D+R+ LE+A L N+V G V + S G+ Q AR F +
Sbjct: 1377 -----CTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKS 1431
Query: 543 KYAVLDEATSALTEEVESELYRIGQQ--LGMTFISVGHRQSLEKFHSLVLKLCGG 595
++DEAT+++ E+ L ++ T +++ HR S LVL G
Sbjct: 1432 SILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEG 1486
Score = 41.2 bits (95), Expect = 0.003
Identities = 39/175 (22%), Positives = 65/175 (37%), Gaps = 20/175 (11%)
Query: 404 IKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV------------QMLTDF 451
+ ++ ++I GQ +I G G GK+SLL + G + G V +
Sbjct: 652 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 711
Query: 452 GPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEG 511
+ V + QKP+ + T+ E + + + +R + L +
Sbjct: 712 NRYSVAYAAQKPWLLNATVEENITF--------GSPFNKQRYKAVTDACSLQPDIDLLPF 763
Query: 512 LDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIG 566
DQ LS G+ QR+ AR Y LD+ SAL + L + G
Sbjct: 764 GDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEG 818
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 54.7 bits (130), Expect = 2e-07
Identities = 64/295 (21%), Positives = 122/295 (41%), Gaps = 25/295 (8%)
Query: 311 SKNAFVCIYLISCFTQLIDLSTTLSDVAGYTHRIGQLRETLLDMSLKSQDCEILGESEWG 370
S + V + L+ T L+ + ++A ++G +++ ++++S++ E G
Sbjct: 1243 SNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMGAVKKVNSFLTMESENYE-------G 1295
Query: 371 LDTPPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGNTGTGKTSL 430
P P P + + + + ++ KP++K + I GQ + I G TG+GK+SL
Sbjct: 1296 TMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGSGKSSL 1355
Query: 431 LRVLGGLWTSTRGSVQM----LTDFGPH----GVLFLPQKPFFTDGTLREQVIYPLKEVY 482
+ G + + ++ H + + Q P G++R + K
Sbjct: 1356 SLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLDPECK--- 1412
Query: 483 PDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSFARLFYLQP 542
D+R+ LE+A L N+V G V + S G+ Q AR F +
Sbjct: 1413 -----CTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKS 1467
Query: 543 KYAVLDEATSALTEEVESELYRIGQQ--LGMTFISVGHRQSLEKFHSLVLKLCGG 595
++DEAT+++ E+ L ++ T +++ HR S LVL G
Sbjct: 1468 SILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEG 1522
Score = 41.2 bits (95), Expect = 0.003
Identities = 39/175 (22%), Positives = 65/175 (37%), Gaps = 20/175 (11%)
Query: 404 IKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSV------------QMLTDF 451
+ ++ ++I GQ +I G G GK+SLL + G + G V +
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 452 GPHGVLFLPQKPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEG 511
+ V + QKP+ + T+ E + + + +R + L +
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITF--------GSPFNKQRYKAVTDACSLQPDIDLLPF 799
Query: 512 LDQQVDWNWYDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRIG 566
DQ LS G+ QR+ AR Y LD+ SAL + L + G
Sbjct: 800 GDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEG 854
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 54.3 bits (129), Expect = 3e-07
Identities = 59/208 (28%), Positives = 87/208 (41%), Gaps = 23/208 (11%)
Query: 366 ESEWGLDT---PPGWPAAEPADTAFLLERVSISAPSSDKPLIKDLSLKISEGQSLLITGN 422
E+ W L T P WP + R P + ++ +S KI G+ + I G
Sbjct: 1245 EAPWRLPTCAAQPPWPQGGQIEFRDFGLRYRPELPLA----VQGVSFKIHAGEKVGIVGR 1300
Query: 423 TGTGKTSLLRVLGGLWTSTRGSVQM----LTDFGPH----GVLFLPQKPFFTDGTLREQV 474
TG GK+SL L L + G + + + G H + +PQ P G+LR +
Sbjct: 1301 TGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL 1360
Query: 475 IYPLKEVYPDSGSADDERILRFLELAGLSNLVARTEGLDQQVDWNWYDVLSPGEMQRLSF 534
L+E DE I LE L LVA G Q + + LS G+ Q L
Sbjct: 1361 DL-LQE-------HSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCL 1412
Query: 535 ARLFYLQPKYAVLDEATSALTEEVESEL 562
AR + + +LDEAT+A+ E ++
Sbjct: 1413 ARALLRKTQILILDEATAAVDPGTELQM 1440
Score = 47.8 bits (112), Expect = 3e-05
Identities = 51/205 (24%), Positives = 86/205 (41%), Gaps = 20/205 (9%)
Query: 402 PLIKDLSLKISEGQSLLITGNTGTGKTSLLRVLGGLWTSTRGSVQMLTDFGPHGVLFLPQ 461
P + ++L + +G L + G G GK+SLL L G + G V + V ++PQ
Sbjct: 644 PCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSI-----EGAVAYVPQ 698
Query: 462 KPFFTDGTLREQVIYPLKEVYPDSGSADDERILRFLELAGLS-NLVARTEGLDQQVDWNW 520
+ + + ++ E V + D + R LE L ++ + EG+ +
Sbjct: 699 EAWVQNTSVVENVCF--------GQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQG 750
Query: 521 YDVLSPGEMQRLSFARLFYLQPKYAVLDEATSALTEEVESELYRI-----GQQLGMTFIS 575
+ LS G+ QRLS AR Y + +LD+ +AL V ++ G G T I
Sbjct: 751 MN-LSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRIL 809
Query: 576 VGHRQSLEKFHSLVLKLCGGGRWEL 600
V H + ++ L G E+
Sbjct: 810 VTHALHILPQADWIIVLANGAIAEM 834
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.139 0.419
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,155,151
Number of Sequences: 37866
Number of extensions: 936217
Number of successful extensions: 2664
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 72
Number of HSP's successfully gapped in prelim test: 12
Number of HSP's that attempted gapping in prelim test: 2440
Number of HSP's gapped (non-prelim): 159
length of query: 606
length of database: 18,247,518
effective HSP length: 108
effective length of query: 498
effective length of database: 14,157,990
effective search space: 7050679020
effective search space used: 7050679020
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.