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Search of human proteins with 4826772
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4826772 insulin-like growth factor binding protein, acid
labile subunit isoform 2 precursor [Homo sapiens]
(605 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4826772 insulin-like growth factor binding protein, acid labi... 1214 0.0
gi|225579152 insulin-like growth factor binding protein, acid la... 1206 0.0
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 192 6e-49
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 192 6e-49
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 183 5e-46
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 172 8e-43
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 167 3e-41
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 164 3e-40
gi|194440719 chondroadherin-like [Homo sapiens] 162 1e-39
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 161 2e-39
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 159 9e-39
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 158 1e-38
gi|226342931 podocan-like 1 isoform 1 [Homo sapiens] 155 8e-38
gi|226342933 podocan-like 1 isoform 2 [Homo sapiens] 154 2e-37
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 152 9e-37
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 150 2e-36
gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens] 147 3e-35
gi|193083139 leucine rich repeat containing 32 precursor [Homo s... 146 6e-35
gi|5031707 leucine rich repeat containing 32 precursor [Homo sap... 146 6e-35
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 145 1e-34
gi|4507531 toll-like receptor 3 [Homo sapiens] 144 2e-34
gi|198041768 synleurin [Homo sapiens] 142 7e-34
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 141 2e-33
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 140 3e-33
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 140 3e-33
gi|45505137 podocan [Homo sapiens] 140 4e-33
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 136 6e-32
gi|7662320 leucine-rich repeats and immunoglobulin-like domains ... 136 6e-32
gi|13194201 reticulon 4 receptor precursor [Homo sapiens] 131 2e-30
gi|188528675 slit homolog 1 [Homo sapiens] 130 5e-30
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 1214 bits (3142), Expect = 0.0
Identities = 605/605 (100%), Positives = 605/605 (100%)
Query: 1 MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFC 60
MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFC
Sbjct: 1 MALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFC 60
Query: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120
SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG
Sbjct: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120
Query: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180
LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN
Sbjct: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180
Query: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 240
SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ
Sbjct: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQ 240
Query: 241 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 300
LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN
Sbjct: 241 LPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN 300
Query: 301 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360
AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG
Sbjct: 301 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360
Query: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN
Sbjct: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
Query: 421 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP
Sbjct: 421 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
Query: 481 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDC 540
LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDC
Sbjct: 481 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDC 540
Query: 541 GCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEA 600
GCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEA
Sbjct: 541 GCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEA 600
Query: 601 HFAPC 605
HFAPC
Sbjct: 601 HFAPC 605
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 1206 bits (3119), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 6 GGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNL 65
GGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNL
Sbjct: 44 GGLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNL 103
Query: 66 TRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLC 125
TRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLC
Sbjct: 104 TRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLC 163
Query: 126 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 185
HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL
Sbjct: 164 HLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVL 223
Query: 186 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 245
PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ
Sbjct: 224 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 283
Query: 246 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305
KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL
Sbjct: 284 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 343
Query: 306 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA
Sbjct: 344 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 403
Query: 366 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 425
VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI
Sbjct: 404 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 463
Query: 426 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF 485
EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF
Sbjct: 464 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF 523
Query: 486 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK 545
WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK
Sbjct: 524 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK 583
Query: 546 ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 605
ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC
Sbjct: 584 ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDLRDLSEAHFAPC 643
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 192 bits (489), Expect = 6e-49
Identities = 154/472 (32%), Positives = 210/472 (44%), Gaps = 61/472 (12%)
Query: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
N L + + L F + AL +L + N LSR+ G F LGSL L+L N L
Sbjct: 60 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 119
Query: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242
VLP F+GL SL L+L+ N+L +QPA FS + L+EL L N L I F L
Sbjct: 120 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 179
Query: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302
L KL L +N + ++P F L L+ L L NR+ + TF GL+ L+ L L N I
Sbjct: 180 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 239
Query: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
L P F + H L+ L L +N I QL F L QL LTL N L+E+ G F +
Sbjct: 240 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 299
Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
N+ + L N + +LP+ VF L +L L L + + I P F GL+
Sbjct: 300 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLT------------ 347
Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
EL EL L +N L L +F+ L L+ + L NRL +LP + +
Sbjct: 348 ------------ELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVN 395
Query: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGC 542
+ + +N+LE LP + LG+L L L + NPW C
Sbjct: 396 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD--------------------NPWRCDS 435
Query: 543 PLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 594
+ LR++ L N PR G D P C SP V G L
Sbjct: 436 DILPLRNWLLLNQ---PRL------GTDTVP--------VCFSPANVRGQSL 470
Score = 185 bits (469), Expect = 1e-46
Identities = 136/431 (31%), Positives = 212/431 (49%), Gaps = 11/431 (2%)
Query: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
CP+ C CS + C+ + +P +P +L + +++ + + F N+S+L
Sbjct: 31 CPSECTCSRASQVE-----CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 85
Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
L ++ +L + P A L +L +L L N+L+ L +G F +L SL LS+N+L +
Sbjct: 86 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 145
Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
++ F +L +L L N L +PD AF L L +L L N L ++ P +F L L
Sbjct: 146 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 205
Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
+ L L N L I F L LQ+L L +N I ++PG F L+ L LS+N ++
Sbjct: 206 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 265
Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
L F L L L L N++ L F + L EL L N I L + F L QL
Sbjct: 266 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 325
Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 400
+VL L NQ+ + GAF GLT + ++L N L++L VFR L L ++ L+ + L +
Sbjct: 326 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 385
Query: 401 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKL 460
+ + F ++GL + L++N L + L +L EL L N P R + L
Sbjct: 386 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN-----PWRCDSDILPL 440
Query: 461 -EYLLLSRNRL 470
+LLL++ RL
Sbjct: 441 RNWLLLNQPRL 451
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 192 bits (489), Expect = 6e-49
Identities = 154/472 (32%), Positives = 210/472 (44%), Gaps = 61/472 (12%)
Query: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
N L + + L F + AL +L + N LSR+ G F LGSL L+L N L
Sbjct: 54 NAMSLQILNTHITELNESPFLNISALIALRIEKNELSRITPGAFRNLGSLRYLSLANNKL 113
Query: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLP 242
VLP F+GL SL L+L+ N+L +QPA FS + L+EL L N L I F L
Sbjct: 114 QVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLV 173
Query: 243 RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI 302
L KL L +N + ++P F L L+ L L NR+ + TF GL+ L+ L L N I
Sbjct: 174 GLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFDGLVNLQELALQQNQI 233
Query: 303 ASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLT 362
L P F + H L+ L L +N I QL F L QL LTL N L+E+ G F +
Sbjct: 234 GLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMP 293
Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
N+ + L N + +LP+ VF L +L L L + + I P F GL+
Sbjct: 294 NLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFNGLT------------ 341
Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
EL EL L +N L L +F+ L L+ + L NRL +LP + +
Sbjct: 342 ------------ELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVN 389
Query: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGC 542
+ + +N+LE LP + LG+L L L + NPW C
Sbjct: 390 GLMAIQLQNNQLENLPLGIFDHLGKLCELRLYD--------------------NPWRCDS 429
Query: 543 PLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASPPEVVGLDL 594
+ LR++ L N PR G D P C SP V G L
Sbjct: 430 DILPLRNWLLLNQ---PRL------GTDTVP--------VCFSPANVRGQSL 464
Score = 185 bits (469), Expect = 1e-46
Identities = 136/431 (31%), Positives = 212/431 (49%), Gaps = 11/431 (2%)
Query: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
CP+ C CS + C+ + +P +P +L + +++ + + F N+S+L
Sbjct: 25 CPSECTCSRASQVE-----CTGARIVAVPTPLPWNAMSLQILNTHITELNESPFLNISAL 79
Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
L ++ +L + P A L +L +L L N+L+ L +G F +L SL LS+N+L +
Sbjct: 80 IALRIEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQ 139
Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
++ F +L +L L N L +PD AF L L +L L N L ++ P +F L L
Sbjct: 140 IQPAHFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNL 199
Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
+ L L N L I F L LQ+L L +N I ++PG F L+ L LS+N ++
Sbjct: 200 QVLRLYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQ 259
Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
L F L L L L N++ L F + L EL L N I L + F L QL
Sbjct: 260 LPPSIFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQL 319
Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 400
+VL L NQ+ + GAF GLT + ++L N L++L VFR L L ++ L+ + L +
Sbjct: 320 QVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQ 379
Query: 401 IRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKL 460
+ + F ++GL + L++N L + L +L EL L N P R + L
Sbjct: 380 LPGNIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDN-----PWRCDSDILPL 434
Query: 461 -EYLLLSRNRL 470
+LLL++ RL
Sbjct: 435 RNWLLLNQPRL 445
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 183 bits (464), Expect = 5e-46
Identities = 139/436 (31%), Positives = 208/436 (47%), Gaps = 17/436 (3%)
Query: 13 LLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGV 72
LLL W+ L +P T C AAC C+ D S+ C R L LP +
Sbjct: 18 LLLLWLLL-----LRLEPVTAAAGPRAPCAAACTCAGD------SLDCGGRGLAALPGDL 66
Query: 73 PGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERN 132
P T++L L N LS + PA F++L +L + L +L ++ P ++ L L+ N
Sbjct: 67 PSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHN 125
Query: 133 QLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRG 192
++RS+ +L L LS N ++ + + F + +LNL N + L AF G
Sbjct: 126 KIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDG 185
Query: 193 LG-SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 251
L SL L L+ NR+ L F L L +LDL+RN +R I+ F L L+ L L R
Sbjct: 186 LSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQR 244
Query: 252 NLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFK 311
N I+ + GAF GL + L L +N + + + GL L L LS+N+IA + + +
Sbjct: 245 NNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWS 304
Query: 312 DLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSG 371
L EL L N + +L E S L L VL L HN + + GAF GL ++ V++L
Sbjct: 305 FCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDH 364
Query: 372 NCLRNLPEQ---VFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQ 428
N + E F GL L L L G+ + + F+GL GL L L N + ++
Sbjct: 365 NEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFD 424
Query: 429 SLWGLAELLELDLTSN 444
+ + L EL ++S+
Sbjct: 425 AFVKMKNLKELHISSD 440
Score = 154 bits (390), Expect = 2e-37
Identities = 127/424 (29%), Positives = 198/424 (46%), Gaps = 16/424 (3%)
Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
LNL +N L+ + A F L +L+E+ L N L + P+L + + + L L N +R+++
Sbjct: 73 LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAV-PSLGAASSHVVSLFLQHNKIRSVE 131
Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLL-GLR 293
+ L+ L L N I V F ++ L+L+ NR+ L F GL L
Sbjct: 132 GSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKELNLAGNRIGTLELGAFDGLSRSLL 191
Query: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEV 353
LRLS N I L R FK L L +L L NRIR + +F+GL LEVL L N + ++
Sbjct: 192 TLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIEGLTFQGLNSLEVLKLQRNNISKL 250
Query: 354 KAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLR 413
GAF GL+ + V++L N L + GL LH LHL + + RI ++ L
Sbjct: 251 TDGAFWGLSKMHVLHLEYNSLVEVNSGSLYGLTALHQLHLSNNSIARIHRKGWSFCQKLH 310
Query: 414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA-- 471
L L N L ++E+SL L+ L L L+ N ++H+ F+GL L L L N ++
Sbjct: 311 ELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIAEGAFKGLRSLRVLDLDHNEISGT 370
Query: 472 -ELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPP 526
E + A L L + N+++++ + L L +L+L N++R+ +
Sbjct: 371 IEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEGLEHLNLGGNAIRSVQFDAFVKMK 430
Query: 527 GLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP 586
L+ L + + + C C LK L P + R +QA P + +I P
Sbjct: 431 NLKELHISSDSFLCDCQLKWL------PPWLIGRMLQAFVTATCAHPESLKGQSIFSVPP 484
Query: 587 PEVV 590
V
Sbjct: 485 ESFV 488
Score = 61.2 bits (147), Expect = 3e-09
Identities = 48/154 (31%), Positives = 72/154 (46%), Gaps = 3/154 (1%)
Query: 79 LWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLA 138
L L N+++ + + L L L L L+ ++L L +L L L N + +A
Sbjct: 288 LHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHIA 347
Query: 139 LGTFAHTPALASLGLSNNRLS-RLED--GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGS 195
G F +L L L +N +S +ED G F GL SL L L N + + AF GL
Sbjct: 348 EGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLEG 407
Query: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNA 229
L L L GN + +Q F + L+EL +S ++
Sbjct: 408 LEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDS 441
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 172 bits (436), Expect = 8e-43
Identities = 138/449 (30%), Positives = 215/449 (47%), Gaps = 16/449 (3%)
Query: 14 LLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVP 73
LL ++ALG G P A P C A C C D D CS + LT +P+G+
Sbjct: 7 LLCFLALGLLGSAG-----PSGAAPPLCAAPCSCDGDRRVD-----CSGKGLTAVPEGLS 56
Query: 74 GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 133
TQAL + NN++ +P AF+N L L L G L + P+AL GL+ L L L+ NQ
Sbjct: 57 AFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQ 116
Query: 134 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 193
L+++ AL SL L N ++ + + FEGL L L L NSL +P L
Sbjct: 117 LKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNL 176
Query: 194 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 253
+L+ L LA N+++ + F+ L+ L L L N +R++ + F L L+ L L+ N
Sbjct: 177 PTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
Query: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313
+ P A L +L+ L N ++ + + F G LR + L N ++ + F +L
Sbjct: 237 LGEF-PQAIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNL 295
Query: 314 HFLEELQL-GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
L L + G + ++Q + G LE LTL ++ + + ++LS N
Sbjct: 296 SDLHSLVIRGASMVQQFP--NLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYN 353
Query: 373 CLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWG 432
+R+LP F G L + L+ + + +I+ TF GL LR L L N + I ++
Sbjct: 354 NIRDLPS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFAT 411
Query: 433 LAELLELDLTSNQLTHLPHRLFQGLGKLE 461
L + LD++ N+LT P GL +L+
Sbjct: 412 LGPITNLDVSFNELTSFPTEGLNGLNQLK 440
Score = 150 bits (379), Expect = 3e-36
Identities = 120/394 (30%), Positives = 183/394 (46%), Gaps = 26/394 (6%)
Query: 167 EGLGSLWD-LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDL 225
EGL + L++ N++ LP+ AF+ L EL LAGN L+++ P SGL EL+ L L
Sbjct: 53 EGLSAFTQALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTL 112
Query: 226 SRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDT 285
N L+ + + L LQ L LD N I +V +F GL LR L L N + +
Sbjct: 113 QNNQLKTVPSEAIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHP 172
Query: 286 FPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTL 345
L L+ L L+ N I+S+ F +L L L L +N+IR L++ F+GL LE L L
Sbjct: 173 LSNLPTLQALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDL 232
Query: 346 DHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHT 405
++N L E A L ++ + N + +P+ F G L ++HL + L +
Sbjct: 233 NYNNLGEFPQ-AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSA 291
Query: 406 FTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRL------------ 453
F LS L L ++ +V + +L G L L LT +++ +P+ L
Sbjct: 292 FHNLSDLHSLVIRGASMVQ-QFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDL 350
Query: 454 ----------FQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 503
F G LE + L RN++ ++ L LD+S N + + + A
Sbjct: 351 SYNNIRDLPSFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFA 410
Query: 504 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
LG + L + N L +F T GL +L L GN
Sbjct: 411 TLGPITNLDVSFNELTSFPTEGLNGLNQLKLVGN 444
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 167 bits (423), Expect = 3e-41
Identities = 143/440 (32%), Positives = 206/440 (46%), Gaps = 12/440 (2%)
Query: 31 GTPGEAEGP-ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 89
G P GP ACPA C C +D LS CS L+ +P + T L L NNL+ +
Sbjct: 24 GAPQPGPGPTACPAPCHCQ--EDGIMLSADCSELGLSAVPGDLDPLTAYLDLSMNNLTEL 81
Query: 90 PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 149
P F +L L L L G L + QA GL +L L L+ NQL + P+L
Sbjct: 82 QPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQ 141
Query: 150 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 209
SL L N +S + + FEGL SL L L N+L +P A L +L+ + LA NR++++
Sbjct: 142 SLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHI 201
Query: 210 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 269
F L L L L N ++ + + F L L+ L L+ N + P A L L+
Sbjct: 202 PDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQ 260
Query: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQL-GHNRIRQ 328
L +N + + E F G L+ + N I + F+ L L L L G I++
Sbjct: 261 ELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQE 320
Query: 329 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKL 388
+ +G LE+LTL ++ + +G L + V+ LS N + LP KL
Sbjct: 321 FPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKL 376
Query: 389 HSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH 448
+ L+ + + I TF+ LS L+ L L N + I ++ L L++LDLT NQLT
Sbjct: 377 EEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTT 436
Query: 449 LPHRLFQGLGKLEYLLLSRN 468
LP GLG L +L L N
Sbjct: 437 LP---LAGLGGLMHLKLKGN 453
Score = 154 bits (388), Expect = 3e-37
Identities = 119/351 (33%), Positives = 174/351 (49%), Gaps = 6/351 (1%)
Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
L+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I
Sbjct: 71 LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIP 130
Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
A +LP LQ L LD NLI+ V +F GL +LR L L N + + L L+
Sbjct: 131 AEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQA 190
Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
+ L+ N I+ + F++L L L L +NRI+ L SFEGL LE L L++N+LQE
Sbjct: 191 MTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFP 250
Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414
A L + + N ++ +PE+ F G L ++H + + + F L L
Sbjct: 251 V-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHT 309
Query: 415 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 473
L L NG + I+E L G L L LT + LP + Q L +L L LS N++ EL
Sbjct: 310 LSL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 367
Query: 474 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 524
P +L Q+ + + HNR+ + + L L+ L L N++R+ P+
Sbjct: 368 P--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 416
Score = 150 bits (380), Expect = 2e-36
Identities = 124/394 (31%), Positives = 189/394 (47%), Gaps = 9/394 (2%)
Query: 146 PALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNR 205
P A L LS N L+ L+ GLF L L +L L N L+ +P AF GL SL+ L+L N+
Sbjct: 66 PLTAYLDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 125
Query: 206 LAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGL 265
L + L L+ L L N + + F L L+ L+LD N + + A L
Sbjct: 126 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 185
Query: 266 KALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNR 325
AL+ + L+ NR++ + + F L L VL L +N I L +F+ LH LE L L +N+
Sbjct: 186 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 245
Query: 326 IRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGL 385
+++ + LG+L+ L +N ++ + AF+G + ++ N ++ + F+ L
Sbjct: 246 LQEFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYL 304
Query: 386 GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQ 445
KLH+L L G+ + P G + L L L G+ + L L L+L+ NQ
Sbjct: 305 PKLHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQ 363
Query: 446 LTHLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLA 503
+ LP HR KLE + L NR+ E+ AD L LD+S N + ++ +
Sbjct: 364 IEELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFS 419
Query: 504 PLGRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
L L L L +N L T GL L L+GN
Sbjct: 420 TLHSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 453
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 164 bits (414), Expect = 3e-40
Identities = 142/477 (29%), Positives = 219/477 (45%), Gaps = 43/477 (9%)
Query: 2 ALRKGGLALALLLLSWVALGPRSLEGADPGTPGEAEGPA----CPAACVCSYDDDADELS 57
+LR L LLL + + RS G G G+ G A CP C C D
Sbjct: 5 SLRARAAGLGLLLCAVLGRAGRSDSGGR-GELGQPSGVAAERPCPTTCRCLGD------L 57
Query: 58 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 117
+ CS + L RLP+ +P L L N LS + ++ +L SL + L +L ++ P
Sbjct: 58 LDCSRKRLARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNL 116
Query: 118 LLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNL 177
N+ L L N++ + +L +L LS+N +S L+
Sbjct: 117 GPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ--------------- 161
Query: 178 GWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-LRELDLSRNALRAIKAN 236
AF L L+ L L NR+ ++P F LA L L L+RN + AI
Sbjct: 162 ----------TAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK 210
Query: 237 VFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLR 296
+F +LP+LQ L L+RN I V F GL AL+ L + N V L++ F GL + +L+
Sbjct: 211 MF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQ 269
Query: 297 LSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAG 356
L HN + + L L+EL L N I +++ ++E +L L L N L +
Sbjct: 270 LDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDS 329
Query: 357 AFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG---RIRPHTFTGLSGLR 413
+FLGL+ + +++ N + + + FRGL L +L L+ + + F+GL LR
Sbjct: 330 SFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLR 389
Query: 414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 470
RL L+ N + I +++ GL L LDL+ N + L F + KL+ L L+ + L
Sbjct: 390 RLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 446
Score = 143 bits (360), Expect = 5e-34
Identities = 122/426 (28%), Positives = 200/426 (46%), Gaps = 36/426 (8%)
Query: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207
+A L LS+NRLS ++ L SL ++ L N L +P+ ++ L LAGNR+
Sbjct: 76 VARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIV 134
Query: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 267
+ P L LDLS N + ++ F L +L+ LYL+ N + ++ PG F L
Sbjct: 135 EILPEHLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLAN 192
Query: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
L VL+L+ N I+++ P+ FK L L+ L+L N+I+
Sbjct: 193 T-----------------------LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIK 228
Query: 328 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 387
+ +F+GLG L+ L + N + ++ GAF GL+N+ ++ L N L + + GL
Sbjct: 229 NVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLM 288
Query: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447
L LHL + + RI P + L L L N L +++ S GL+ L L + +N+++
Sbjct: 289 LQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVS 348
Query: 448 HLPHRLFQGLGKLEYLLLSRNRLAELPAD---ALGPLQRAFWLDVSHNRLEALPNSLLAP 504
++ F+GL L+ L L N ++ D A L + L + NR+ ++
Sbjct: 349 YIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTG 408
Query: 505 LGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPR 560
L L +L L +N++ + Q L++L L + C C LK L + +N
Sbjct: 409 LDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN--NFQS 466
Query: 561 FVQAIC 566
FV A C
Sbjct: 467 FVNASC 472
>gi|194440719 chondroadherin-like [Homo sapiens]
Length = 762
Score = 162 bits (409), Expect = 1e-39
Identities = 184/607 (30%), Positives = 240/607 (39%), Gaps = 107/607 (17%)
Query: 35 EAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF 94
+A CP AC+C D V C +NLT +PD +P TQ L L GN L +P AAF
Sbjct: 27 QAAAQRCPQACIC----DNSRRHVACRYQNLTEVPDAIPELTQRLDLQGNLLKVIPAAAF 82
Query: 95 QN------------------------LSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
Q L L LNL L L +AL GL +L L LE
Sbjct: 83 QGVPHLTHLDLRHCEVELVAEGAFRGLGRLLLLNLASNHLRELPQEALDGLGSLRRLELE 142
Query: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 190
N L L GTF ALA+L L++N L L F+GL + L L N+L+VL A
Sbjct: 143 GNALEELRPGTFGALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEAL 202
Query: 191 RGLGSLRELVLAGNRLAYL------------------QPALFSG------LAELRELDLS 226
GL +LR L L N L L P ++G L LREL L
Sbjct: 203 AGLPALRRLSLHHNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLD 262
Query: 227 RNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN------RVAG 280
AL+A+ F PRL L L N + + P G LR L L N +
Sbjct: 263 GGALQALGPRAFAHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARP 320
Query: 281 LLEDTFPGLLGLRVL---------RLSHNAIASLRPRTFK-------DLHFLEELQL--- 321
LLE L RV RL A+ +LRP + + LEE +
Sbjct: 321 LLE----WLARARVRSDGACQGPRRLRGEALDALRPWDLRCPGDAAQEEEELEERAVAGP 376
Query: 322 -----------GHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 370
G R R+ + + + + LQ V G ++ +++L
Sbjct: 377 RAPPRGPPRGPGEERAVAPCPRACVCVPESRHSSCEGCGLQAVPRGF---PSDTQLLDLR 433
Query: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 430
N ++P F GLG L SLHL+ + + GL L L+L DN L G+ +L
Sbjct: 434 RNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAAL 493
Query: 431 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 490
G L L L N+ +P + L L L L N + L LG + W+ +S
Sbjct: 494 EGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLS 553
Query: 491 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLERLWLEGNPWDCGCPLKA 546
NR+ + L P L L L N LR P L L L GN PL+A
Sbjct: 554 GNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGN------PLRA 607
Query: 547 LRDFALQ 553
LRD A Q
Sbjct: 608 LRDGAFQ 614
Score = 125 bits (314), Expect = 1e-28
Identities = 102/307 (33%), Positives = 139/307 (45%), Gaps = 9/307 (2%)
Query: 21 GPRSLEGADPGTPGEAEGPA-CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQAL 79
GPR+ P PGE A CP ACVC + C L +P G P TQ L
Sbjct: 375 GPRAPPRGPPRGPGEERAVAPCPRACVCVPESRHSS----CEGCGLQAVPRGFPSDTQLL 430
Query: 80 WLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLAL 139
L N+ SVP AAF L L L+LQ + LE AL GL L +L+L NQL L+
Sbjct: 431 DLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSA 490
Query: 140 GTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLREL 199
P L L L NR ++ L SL+ L+L N++ L +LR +
Sbjct: 491 AALEGAPRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWV 550
Query: 200 VLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAP 259
L+GNR+ + EL +L L RN LR + LP L +L L N + A+
Sbjct: 551 YLSGNRITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRD 610
Query: 260 GAFLGL-KALRWLDLSHNRVAGLLEDTFPGL-LGLRVLRLSHNAIASLRPRTFKDLHFLE 317
GAF + ++L+ L L+ + + + F GL GL+ L L N + +L L LE
Sbjct: 611 GAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRAL--PALPSLSQLE 668
Query: 318 ELQLGHN 324
+ L N
Sbjct: 669 LIDLSSN 675
Score = 112 bits (279), Expect = 1e-24
Identities = 154/551 (27%), Positives = 206/551 (37%), Gaps = 93/551 (16%)
Query: 71 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
G G L L N L +P AFQ L + +L L L L P+AL GL L L L
Sbjct: 155 GALGALATLNLAHNALVYLPAMAFQGLLRVRWLRLSHNALSVLAPEALAGLPALRRLSLH 214
Query: 131 RNQLRSL----------------------------------------------ALG--TF 142
N+L++L ALG F
Sbjct: 215 HNELQALPGPVLSQARGLARLELGHNPLTYAGEEDGLALPGLRELLLDGGALQALGPRAF 274
Query: 143 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL----------------AVLP 186
AH P L +L L N+L L +G G L L L N L V
Sbjct: 275 AHCPRLHTLDLRGNQLDTLPP--LQGPGQLRRLRLQGNPLWCGCQARPLLEWLARARVRS 332
Query: 187 DAAFRGLGSLRELVLAGNRLAYLQP--ALFSGLAELRELDLSRNALRAIKANVFVQLPRL 244
D A +G LR G L L+P G A E +L A+ +A PR
Sbjct: 333 DGACQGPRRLR-----GEALDALRPWDLRCPGDAAQEEEELEERAVAGPRAP-----PRG 382
Query: 245 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL----LEDTFPGLLGLRVLRLSHN 300
A P A + + R H+ G + FP ++L L N
Sbjct: 383 PPRGPGEERAVAPCPRACVCVPESR-----HSSCEGCGLQAVPRGFPS--DTQLLDLRRN 435
Query: 301 AIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG 360
S+ F L L L L H I +L + GLG+L L L NQL + A A G
Sbjct: 436 HFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLSAAALEG 495
Query: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
+ + L N +P R L L SLHL+ + + R+ P LR ++L N
Sbjct: 496 APRLGYLYLERNRFLQVPGAALRALPSLFSLHLQDNAVDRLAPGDLGRTRALRWVYLSGN 555
Query: 421 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
+ + +L EL +L L NQL +P +GL L L LS N L L A P
Sbjct: 556 RITEVSLGALGPARELEKLHLDRNQLREVPTGALEGLPALLELQLSGNPLRALRDGAFQP 615
Query: 481 LQRAF-WLDVSHNRLEALPNSLLAPLG-RLRYLSLRNNSLRTF--TPQPPGLERLWLEGN 536
+ R+ L ++ + LE + + LG L+ L L+ N LR P LE + L N
Sbjct: 616 VGRSLQHLFLNSSGLEQICPGAFSGLGPGLQSLHLQKNQLRALPALPSLSQLELIDLSSN 675
Query: 537 PWDCGCPLKAL 547
P+ C C L L
Sbjct: 676 PFHCDCQLLPL 686
Score = 105 bits (262), Expect = 1e-22
Identities = 106/291 (36%), Positives = 137/291 (47%), Gaps = 35/291 (12%)
Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
L+L N +P AAF GLG L L L +A L+ +GL L L LS N L +
Sbjct: 430 LDLRRNHFPSVPRAAFPGLGHLVSLHLQHCGIAELEAGALAGLGRLIYLYLSDNQLAGLS 489
Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
A PRL LYL+RN V PGA ALR L P L L
Sbjct: 490 AAALEGAPRLGYLYLERNRFLQV-PGA-----ALRAL---------------PSLFSLH- 527
Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
L NA+ L P L + L NRI +++ + +LE L LD NQL+EV
Sbjct: 528 --LQDNAVDRLAPGDLGRTRALRWVYLSGNRITEVSLGALGPARELEKLHLDRNQLREVP 585
Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLS-GL 412
GA GL + + LSGN LR L + F+ +G+ L L L S L +I P F+GL GL
Sbjct: 586 TGALEGLPALLELQLSGNPLRALRDGAFQPVGRSLQHLFLNSSGLEQICPGAFSGLGPGL 645
Query: 413 RRLFLKDNGLVGIEEQSLWGLAELLELDLTSN------QLTHLPHRLFQGL 457
+ L L+ N L + +L L++L +DL+SN QL L HR GL
Sbjct: 646 QSLHLQKNQLRAL--PALPSLSQLELIDLSSNPFHCDCQLLPL-HRWLTGL 693
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 161 bits (407), Expect = 2e-39
Identities = 122/360 (33%), Positives = 172/360 (47%), Gaps = 1/360 (0%)
Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
L+ F G+ L L + + ++ + F L L+ L L+ N++ +L AL + L
Sbjct: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
+L L NALR I N+F +L LQ+L L++N + + F L+ L+ LDLS N +
Sbjct: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
L + L L L N + SL L L ELQ N IR +A +F+ L L
Sbjct: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244
Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 400
LTL N L + + FL N+ ++ L N L LP +F +G L L L + L
Sbjct: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRT 304
Query: 401 IRPHTFTGLSGLRRLFLK-DNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 459
+ F LS LR L + L + + + GL EL L L SN LT LP L +GLGK
Sbjct: 305 LPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGK 364
Query: 460 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 519
L + L RNRL LP L + + HN+LE LP + L RL + L +NS R
Sbjct: 365 LRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
Score = 155 bits (391), Expect = 1e-37
Identities = 133/453 (29%), Positives = 200/453 (44%), Gaps = 53/453 (11%)
Query: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
CP AC C + D A CS ++ R+ AL L N L
Sbjct: 21 CPPACKCVFRDAAQ-----CSGGDVARI--------SALGLPTN---------------L 52
Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
+ L G G L+ Q+ G+ L L + + + ++A GTF+ L +L LS N+++
Sbjct: 53 THILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITH 112
Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
L L + + L L L N+L + F+ L +L+EL L N+L +L +LF+ L L
Sbjct: 113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENL 172
Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
+ LDLS N L + + +L++L L N + ++ G L AL L N +
Sbjct: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
+ F L L L LS N +A L F H L L L N + +L F +G L
Sbjct: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292
Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLS-GNCLRNLPEQVFRGLGKLHSLHLEGSCLG 399
+ L L+ QL+ + A AF L+ + + ++ L LP+ F+GLG+L L L
Sbjct: 293 QELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALH----- 347
Query: 400 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 459
NGL + + L GL +L ++ L N+L LP LF+ L
Sbjct: 348 -------------------SNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSS 388
Query: 460 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHN 492
LE + L N+L LP D G L R + + HN
Sbjct: 389 LESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
Score = 118 bits (296), Expect = 1e-26
Identities = 95/295 (32%), Positives = 134/295 (45%), Gaps = 28/295 (9%)
Query: 261 AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQ 320
+F G+ L+ L +S + ++ + TF L+ L+ LRLS N I L + LE+L
Sbjct: 69 SFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLF 128
Query: 321 LGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPE- 379
L HN +R + + F+ L L+ L L+ NQL + A F L N+ +++LSGN L +LP+
Sbjct: 129 LDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKG 188
Query: 380 -----------------------QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLF 416
+ LG L L + + I P F L L L
Sbjct: 189 LLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLT 248
Query: 417 LKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPAD 476
L N L + L L L N L LP LF +G L+ L L+R +L LPA
Sbjct: 249 LSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAA 308
Query: 477 ALGPLQRAFWLDVSHN-RLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 530
A L R +L V+ + RL ALP LG L+ L+L +N L T P GL R
Sbjct: 309 AFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGL---TALPDGLLR 360
Score = 79.3 bits (194), Expect = 9e-15
Identities = 58/161 (36%), Positives = 76/161 (47%), Gaps = 23/161 (14%)
Query: 71 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
G GG Q LWL+ L ++P AAF+NLS L +L + +L P+
Sbjct: 287 GEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGV------TLSPR-------------- 326
Query: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 190
L +L G F L L L +N L+ L DGL GLG L ++L N L LP A F
Sbjct: 327 ---LSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALF 383
Query: 191 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALR 231
R L SL + L N+L L +F L L E+ L N+ R
Sbjct: 384 RNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
Score = 66.6 bits (161), Expect = 6e-11
Identities = 54/161 (33%), Positives = 76/161 (47%), Gaps = 1/161 (0%)
Query: 359 LGL-TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFL 417
LGL TN+ + L G L Q F G+ L L + S + + P TF+ L L+ L L
Sbjct: 46 LGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRL 105
Query: 418 KDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADA 477
N + + L + L +L L N L + +FQ L L+ L L++N+L LPA
Sbjct: 106 SRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASL 165
Query: 478 LGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
L+ LD+S N L LP LL +L L L +N L
Sbjct: 166 FTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 159 bits (401), Expect = 9e-39
Identities = 119/340 (35%), Positives = 162/340 (47%), Gaps = 11/340 (3%)
Query: 39 PACPAACVCSYDDDADELSVFCSSRNLTRLP--DGVPGGTQALW--LDGNNLSSVPPAAF 94
P CP C C + + C++R L +P +P L L GN ++++ F
Sbjct: 25 PVCPERCDCQHPQH-----LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDF 79
Query: 95 QNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLS 154
L L L+LQ Q+ SL P+ L L L+L N L++LA GT A L L +
Sbjct: 80 HRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYAN 139
Query: 155 NNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALF 214
N +SRL G FEGL SL L L N+L LPDA F LG+L L L NR+ +L F
Sbjct: 140 GNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAF 199
Query: 215 SGLAELRELDLSRNALRAI--KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272
+ L +LR L+LS N L+ A F L L L L N + + P F L L L
Sbjct: 200 AQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLS 259
Query: 273 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 332
L N++ L + F GL LR LRL N ++ L + LH LE L L N + L
Sbjct: 260 LRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPA 319
Query: 333 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
+F LG+L L+L +N L + F + ++L GN
Sbjct: 320 TFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 157 bits (396), Expect = 3e-38
Identities = 114/306 (37%), Positives = 148/306 (48%), Gaps = 30/306 (9%)
Query: 273 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 332
L N + + F L LR L L +N I SL P+TF+ L LEEL LG+N ++ LA
Sbjct: 66 LGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPG 125
Query: 333 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 392
+ L +L +L + N++ + G+F GL ++ + L GN L LP+ VF LG L LH
Sbjct: 126 TLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLH 185
Query: 393 LEG-----------SCLGRIR---------------PHTFTGLSGLRRLFLKDNGLVGIE 426
LE + LG++R TF L L L L N L +
Sbjct: 186 LESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLG 245
Query: 427 EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW 486
+ L L L L NQLTHL F GL L L L NRL++LP L PL
Sbjct: 246 PRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEA 305
Query: 487 LDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGC 542
LD+S N L AL + LGRLR LSLRNN+L + P L RL L+GN W C C
Sbjct: 306 LDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGNGWTCDC 365
Query: 543 PLKALR 548
L+ L+
Sbjct: 366 RLRGLK 371
Score = 80.1 bits (196), Expect = 5e-15
Identities = 52/157 (33%), Positives = 78/157 (49%)
Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
+V +L GN + N+ F LG+L L L+ + + + P TF LS L L+L +N L
Sbjct: 60 DVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLL 119
Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
+ +L L +L L N+++ L F+GL L L L N L LP PL
Sbjct: 120 QALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLG 179
Query: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 519
+L + NR+ L + A LG+LR+L+L N L+
Sbjct: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ 216
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 158 bits (400), Expect = 1e-38
Identities = 118/331 (35%), Positives = 165/331 (49%), Gaps = 13/331 (3%)
Query: 55 ELSVFCSSRNLTRL-----------PDGVPG--GTQALWLDGNNLSSVPPAAFQNLSSLG 101
E F S+ NLT++ PD G + L + G++ ++ F NL+SLG
Sbjct: 65 ETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLG 124
Query: 102 FLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRL 161
L L L +L L L LHL+ NQL++L F L +L L+ N L++L
Sbjct: 125 KLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQL 184
Query: 162 EDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELR 221
+ LF L SL L L N+L+ LP F LGSL+EL L N ++ L P +FS L L
Sbjct: 185 PEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLE 244
Query: 222 ELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGL 281
L L RNA+ + ++F L L L L N++ + G F L L L+HN++ +
Sbjct: 245 RLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETV 304
Query: 282 LEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 341
E TF L LR L LS+NAI L F+DL L +L LG N + L F+ L +LE
Sbjct: 305 AEGTFAHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLE 364
Query: 342 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN 372
+L+L NQL + G F N+ + L GN
Sbjct: 365 LLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 155 bits (392), Expect = 1e-37
Identities = 125/383 (32%), Positives = 172/383 (44%), Gaps = 12/383 (3%)
Query: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAF---QNL 97
CP C C + VFCS L +P +P T+ + + +++ AF NL
Sbjct: 22 CPMGCDCFVQE------VFCSDEELATVPLDIPPYTKNIIFVETSFTTLETRAFGSNPNL 75
Query: 98 SSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNR 157
+ + FLN Q L P A GL L L + + +L+ F++ +L L L+ N
Sbjct: 76 TKVVFLNTQ---LCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNM 132
Query: 158 LSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGL 217
L L +GLF+ L +L L+L N L LP F+ L L+ L LA N LA L LF L
Sbjct: 133 LEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPL 192
Query: 218 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 277
L+ L LS NAL + VF +L LQ+L+LD N I+ + P F L L L L N
Sbjct: 193 TSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNA 252
Query: 278 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 337
+ L F L L L L N + L F L L L HN++ +AE +F L
Sbjct: 253 ITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHL 312
Query: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 397
L L L +N + + AG F L + + L N L L +F+ L KL L L +
Sbjct: 313 SNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQ 372
Query: 398 LGRIRPHTFTGLSGLRRLFLKDN 420
L + F L L L N
Sbjct: 373 LTTLPEGIFDTNYNLFNLALHGN 395
Score = 150 bits (379), Expect = 3e-36
Identities = 128/399 (32%), Positives = 174/399 (43%), Gaps = 51/399 (12%)
Query: 186 PDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQ 245
PDA F GL L +L + G+ L +FS L L +L L+ N L A+ +F L L+
Sbjct: 90 PDA-FGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALE 148
Query: 246 KLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASL 305
L+L N + A+ F L L+ L+L+ N +A L E+ F L L+ L+LS+NA++ L
Sbjct: 149 SLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGL 208
Query: 306 RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
F L L+EL L N I +L + F L LE L L N + + F L N+
Sbjct: 209 PQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLT 268
Query: 366 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 425
++L N LR LP +F L L L + L + TF LS LR L L N + +
Sbjct: 269 FLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHL 328
Query: 426 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAF 485
L EL++L L SN LT L LFQ L KLE L LS+N+L LP
Sbjct: 329 PAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGI-------- 380
Query: 486 WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLK 545
D ++N L L L GNPW C C L
Sbjct: 381 -FDTNYN-----------------------------------LFNLALHGNPWQCDCHLA 404
Query: 546 ALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCA 584
L ++ Q + +Q C G PAY + A
Sbjct: 405 YLFNWLQQYTDRLLN-IQTYCAG-----PAYLKGQVVPA 437
>gi|226342931 podocan-like 1 isoform 1 [Homo sapiens]
Length = 512
Score = 155 bits (393), Expect = 8e-38
Identities = 170/531 (32%), Positives = 219/531 (41%), Gaps = 105/531 (19%)
Query: 3 LRKGGLAL-ALLLLSWVALGPRSLEGA-DPGTP--GEAEGP---ACPAACVCSYDDDADE 55
+ + GLA+ LLL + GP + G D P GE+ P ACP C C D D
Sbjct: 1 MAESGLAMWPSLLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD- 59
Query: 56 LSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS--L 113
C +L PD + Q L L N L +P LS L LNL + S L
Sbjct: 60 ----CDGLDLRVFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGL 115
Query: 114 EPQALLGLENLCHLHLERNQL--------RSLALG-------------TFAHTPALASLG 152
+A L L HL + N+L RSL + TF PAL S+
Sbjct: 116 PDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVY 175
Query: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 212
L NN+LS A LP AFRG ++ L L+ N+L+YL P+
Sbjct: 176 LHNNQLSN----------------------AGLPPDAFRGSEAIATLSLSNNQLSYLPPS 213
Query: 213 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272
L P L++L+L NLI+ V GA LR L
Sbjct: 214 L---------------------------PPSLERLHLQNNLISKVPRGALSRQTQLRELY 246
Query: 273 LSHNRV--AGLLEDTFPGLLGLRVLRLSHNAIASL---RPRTFKDLHFLEELQLGHNRIR 327
L HN++ +GL TF L L L LSHN + ++ PRT LH LG NRIR
Sbjct: 247 LQHNQLTDSGLDATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH------LGRNRIR 300
Query: 328 QLAERSFEGLGQLEVLTLDHNQL--QEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGL 385
Q+ G L L L HNQL + AGA L + ++L GN L +P + R L
Sbjct: 301 QVEAARLHGARGLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRL 360
Query: 386 GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVG--IEEQSLWGLAELLELDLTS 443
L H + LG GL L L N L + ++ L L LDL
Sbjct: 361 RALVLPHNHVAALG---ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAG 417
Query: 444 NQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
NQLT LP L GL L+ L RN+L L + L L + L ++HNRL
Sbjct: 418 NQLTRLPMGLPTGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRL 465
Score = 103 bits (258), Expect = 3e-22
Identities = 99/274 (36%), Positives = 126/274 (45%), Gaps = 17/274 (6%)
Query: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL--GSLEPQAL 118
S+ L+ LP +P + L L N +S VP A + L L LQ QL L+
Sbjct: 203 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 262
Query: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178
L +L +L L NQL ++ G LA L L NR+ ++E G L L L
Sbjct: 263 SKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQ 319
Query: 179 WNSLAV--LPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKAN 236
N L LP A R L L L L GN L + PAL LR L L N + A+ A
Sbjct: 320 HNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGAR 376
Query: 237 VFVQLPRLQKLYLDRNLIAA--VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL-LGLR 293
V P L +L L N +A+ V AF L+ALR LDL+ N++ L GL GLR
Sbjct: 377 DLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPM----GLPTGLR 432
Query: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
L+L N + L P L L EL L HNR+R
Sbjct: 433 TLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 466
Score = 47.8 bits (112), Expect = 3e-05
Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 364 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 423
V ++ G LR P+ + R L L+ + L + + + LSGLR L L +N +
Sbjct: 55 VDTVDCDGLDLRVFPDNITRAA---QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLIS 111
Query: 424 --GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALG-- 479
G+ +++ L +L L + N+L+ P L + L + L+ N++ E+ G
Sbjct: 112 SEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVAD---LAANQVMEIFPLTFGEK 168
Query: 480 PLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLERLWLEGN 536
P R+ +L + LP + LSL NN L P PP LERL L+ N
Sbjct: 169 PALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 226
>gi|226342933 podocan-like 1 isoform 2 [Homo sapiens]
Length = 510
Score = 154 bits (390), Expect = 2e-37
Identities = 167/520 (32%), Positives = 213/520 (40%), Gaps = 104/520 (20%)
Query: 13 LLLSWVALGPRSLEGA-DPGTP--GEAEGP---ACPAACVCSYDDDADELSVFCSSRNLT 66
LLL + GP + G D P GE+ P ACP C C D D C +L
Sbjct: 10 LLLLLLLPGPPPVAGLEDAAFPHLGESLQPLPRACPLRCSCPRVDTVD-----CDGLDLR 64
Query: 67 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENL 124
PD + Q L L N L +P LS L LNL + S L +A L L
Sbjct: 65 VFPDNITRAAQHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLISSEGLPDEAFESLTQL 124
Query: 125 CHLHLERNQL--------RSLALG-------------TFAHTPALASLGLSNNRLSRLED 163
HL + N+L RSL + TF PAL S+ L NN+LS
Sbjct: 125 QHLCVAHNKLSVAPQFLPRSLRVADLAANQVMEIFPLTFGEKPALRSVYLHNNQLSN--- 181
Query: 164 GLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELREL 223
A LP AFRG ++ L L+ N+L+YL P+L
Sbjct: 182 -------------------AGLPPDAFRGSEAIATLSLSNNQLSYLPPSL---------- 212
Query: 224 DLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV--AGL 281
P L++L+L NLI+ V GA LR L L HN++ +GL
Sbjct: 213 -----------------PPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGL 255
Query: 282 LEDTFPGLLGLRVLRLSHNAIASL---RPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 338
TF L L L LSHN + ++ PRT LH LG NRIRQ+ G
Sbjct: 256 DATTFSKLHSLEYLDLSHNQLTTVPAGLPRTLAILH------LGRNRIRQVEAARLHGAR 309
Query: 339 QLEVLTLDHNQL--QEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS 396
L L L HNQL + AGA L + ++L GN L +P + R L L H +
Sbjct: 310 GLRYLLLQHNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPALPRRLRALVLPHNHVA 369
Query: 397 CLGRIRPHTFTGLSGLRRLFLKDNGLVG--IEEQSLWGLAELLELDLTSNQLTHLPHRLF 454
LG GL L L N L + ++ L L LDL NQLT LP L
Sbjct: 370 ALG---ARDLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPMGLP 426
Query: 455 QGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
GL L+ L RN+L L + L L + L ++HNRL
Sbjct: 427 TGLRTLQ---LQRNQLRMLEPEPLAGLDQLRELSLAHNRL 463
Score = 103 bits (258), Expect = 3e-22
Identities = 99/274 (36%), Positives = 126/274 (45%), Gaps = 17/274 (6%)
Query: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQL--GSLEPQAL 118
S+ L+ LP +P + L L N +S VP A + L L LQ QL L+
Sbjct: 201 SNNQLSYLPPSLPPSLERLHLQNNLISKVPRGALSRQTQLRELYLQHNQLTDSGLDATTF 260
Query: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178
L +L +L L NQL ++ G LA L L NR+ ++E G L L L
Sbjct: 261 SKLHSLEYLDLSHNQLTTVPAGL---PRTLAILHLGRNRIRQVEAARLHGARGLRYLLLQ 317
Query: 179 WNSLAV--LPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKAN 236
N L LP A R L L L L GN L + PAL LR L L N + A+ A
Sbjct: 318 HNQLGSSGLPAGALRPLRGLHTLHLYGNGLDRVPPAL---PRRLRALVLPHNHVAALGAR 374
Query: 237 VFVQLPRLQKLYLDRNLIAA--VAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGL-LGLR 293
V P L +L L N +A+ V AF L+ALR LDL+ N++ L GL GLR
Sbjct: 375 DLVATPGLTELNLAYNRLASARVHHRAFRRLRALRSLDLAGNQLTRLPM----GLPTGLR 430
Query: 294 VLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
L+L N + L P L L EL L HNR+R
Sbjct: 431 TLQLQRNQLRMLEPEPLAGLDQLRELSLAHNRLR 464
Score = 47.8 bits (112), Expect = 3e-05
Identities = 50/178 (28%), Positives = 80/178 (44%), Gaps = 11/178 (6%)
Query: 364 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 423
V ++ G LR P+ + R L L+ + L + + + LSGLR L L +N +
Sbjct: 53 VDTVDCDGLDLRVFPDNITRAA---QHLSLQNNQLQELPYNELSRLSGLRTLNLHNNLIS 109
Query: 424 --GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALG-- 479
G+ +++ L +L L + N+L+ P L + L + L+ N++ E+ G
Sbjct: 110 SEGLPDEAFESLTQLQHLCVAHNKLSVAPQFLPRSLRVAD---LAANQVMEIFPLTFGEK 166
Query: 480 PLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ-PPGLERLWLEGN 536
P R+ +L + LP + LSL NN L P PP LERL L+ N
Sbjct: 167 PALRSVYLHNNQLSNAGLPPDAFRGSEAIATLSLSNNQLSYLPPSLPPSLERLHLQNN 224
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 152 bits (384), Expect = 9e-37
Identities = 118/350 (33%), Positives = 173/350 (49%), Gaps = 6/350 (1%)
Query: 176 NLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKA 235
+L N+L L F L L EL L+GN L+++ FSGL L+ L L N L I A
Sbjct: 20 DLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPA 79
Query: 236 NVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVL 295
+LP LQ L LD NLI+ V +F GL +LR L L N + + L L+ +
Sbjct: 80 EALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAM 139
Query: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 355
L+ N I+ + F++L L L L +NRI+ L SFEGL LE L L++N+LQE
Sbjct: 140 TLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPV 199
Query: 356 GAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRL 415
A L + + N ++ +PE+ F G L ++H + + + F L L L
Sbjct: 200 -AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTL 258
Query: 416 FLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELP 474
L NG + I+E L G L L LT + LP + Q L +L L LS N++ ELP
Sbjct: 259 SL--NGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELP 316
Query: 475 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQ 524
+L Q+ + + HNR+ + + L L+ L L N++R+ P+
Sbjct: 317 --SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE 364
Score = 147 bits (371), Expect = 3e-35
Identities = 121/392 (30%), Positives = 189/392 (48%), Gaps = 9/392 (2%)
Query: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLA 207
+++ LS N L+ L+ GLF L L +L L N L+ +P AF GL SL+ L+L N+L
Sbjct: 16 ISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLG 75
Query: 208 YLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKA 267
+ L L+ L L N + + F L L+ L+LD N + + A L A
Sbjct: 76 GIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPA 135
Query: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
L+ + L+ NR++ + + F L L VL L +N I L +F+ LH LE L L +N+++
Sbjct: 136 LQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQ 195
Query: 328 QLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK 387
+ + LG+L+ L +N ++ + AF+G + ++ N ++ + F+ L K
Sbjct: 196 EFPV-AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPK 254
Query: 388 LHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLT 447
LH+L L G+ + P G + L L L G+ + L L L+L+ NQ+
Sbjct: 255 LHTLSLNGAMDIQEFP-DLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE 313
Query: 448 HLP--HRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPL 505
LP HR KLE + L NR+ E+ AD L LD+S N + ++ + L
Sbjct: 314 ELPSLHR----CQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTL 369
Query: 506 GRLRYLSLRNNSLRTF-TPQPPGLERLWLEGN 536
L L L +N L T GL L L+GN
Sbjct: 370 HSLVKLDLTDNQLTTLPLAGLGGLMHLKLKGN 401
Score = 138 bits (348), Expect = 1e-32
Identities = 125/389 (32%), Positives = 178/389 (45%), Gaps = 9/389 (2%)
Query: 129 LERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDA 188
L N L L G F H L L LS N LS + F GL SL L L N L +P
Sbjct: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
Query: 189 AFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLY 248
A L SL+ L L N ++ + F GL+ LR L L NAL I LP LQ +
Sbjct: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
Query: 249 LDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPR 308
L N I+ + AF L +L L L +NR+ L +F GL L L L++N + P
Sbjct: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PV 199
Query: 309 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMN 368
+ L L+EL +N I+ + E++F G L+ + N +Q V AF L + ++
Sbjct: 200 AIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
Query: 369 LSGNC-LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 427
L+G ++ P+ +G L L L + + + L LR L L N + E
Sbjct: 260 LNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIE--EL 315
Query: 428 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 487
SL +L E+ L N++ + F L L+ L LS N + + +A L L
Sbjct: 316 PSLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKL 375
Query: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 516
D++ N+L LP LA LG L +L L+ N
Sbjct: 376 DLTDNQLTTLP---LAGLGGLMHLKLKGN 401
Score = 137 bits (345), Expect = 3e-32
Identities = 130/413 (31%), Positives = 185/413 (44%), Gaps = 46/413 (11%)
Query: 39 PACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGT---QALWLDGNNLSSVPPAAFQ 95
P C S A +LS+ NLT L G+ + L L GN+LS +P AF
Sbjct: 4 PRLTLVCQVSIIISARDLSM----NNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFS 59
Query: 96 NLSSLGFLNLQGGQLGSLEPQALL------------------------GLENLCHLHLER 131
L SL L LQ QLG + +AL GL +L HL L+
Sbjct: 60 GLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDD 119
Query: 132 NQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFR 191
N L + + + PAL ++ L+ NR+S + D F+ L SL L+L N + L +F
Sbjct: 120 NALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFE 179
Query: 192 GLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR 251
GL +L L L N+L P L L+EL N ++AI F+ P LQ ++
Sbjct: 180 GLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYD 238
Query: 252 NLIAAVAPGAFLGLKALRWLDLSHNRVAGLLE-DTFPGLLG---LRVLRLSHNAIASLRP 307
N I V AF L L L L+ G ++ FP L G L +L L+ I L
Sbjct: 239 NPIQFVGRSAFQYLPKLHTLSLN-----GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPS 293
Query: 308 RTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVM 367
+ L L L+L HN+I +L S +LE + L HN++ E+ A F L+++ +
Sbjct: 294 GMCQQLPRLRVLELSHNQIEELP--SLHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQAL 351
Query: 368 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
+LS N +R++ + F L L L L + L + GL GL L LK N
Sbjct: 352 DLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTL---PLAGLGGLMHLKLKGN 401
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 150 bits (380), Expect = 2e-36
Identities = 122/367 (33%), Positives = 173/367 (47%), Gaps = 10/367 (2%)
Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
L+L N+++ L L L EL LAGN L Y+ F+GL L+ L L N LR +
Sbjct: 71 LDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVP 130
Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
L LQ L LD N I+ V P F GL +LR L L N + + F L L+
Sbjct: 131 TEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQA 190
Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
+ L+ N I + F +L L L L +NRI L ++ F+GL LE L L++N L E
Sbjct: 191 MTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFP 250
Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414
A L+N+ + N +R++PE+ F G L ++H + + + F L LR
Sbjct: 251 T-AIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRT 309
Query: 415 LFLKDNGLVGIEE-QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAEL 473
L L NG I E L G A L L LT Q++ LP + L L+ L LS N L +L
Sbjct: 310 LTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDL 367
Query: 474 PADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQP----PGLE 529
P+ ++ Q+ +D+ HN + + L LR L+L N + P P L
Sbjct: 368 PSFSV--CQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLI 425
Query: 530 RLWLEGN 536
+L L N
Sbjct: 426 KLDLSSN 432
Score = 148 bits (373), Expect = 2e-35
Identities = 145/463 (31%), Positives = 205/463 (44%), Gaps = 17/463 (3%)
Query: 7 GLALALLLLSWVALGPRSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLT 66
G+ L+L +L +A G G+ P + G CP C C D L V CS L+
Sbjct: 7 GVLLSLPVLLQLATG-----GSSPRSGVLLRG--CPTHCHCE-PDGRMLLRVDCSDLGLS 58
Query: 67 RLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCH 126
LP + T L L NN+S + P +L L L L G L + A GL +L
Sbjct: 59 ELPSNLSVFTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKV 118
Query: 127 LHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLP 186
L L+ NQLR + + +L SL L N +S + F GL SL L L N+L +P
Sbjct: 119 LMLQNNQLRHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIP 178
Query: 187 DAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQK 246
AFR L +L+ + LA N++ ++ F L+ L L L N + ++ F L L+
Sbjct: 179 VQAFRSLSALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLET 238
Query: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLR 306
L L+ N + P A L L+ L N + + E F G L + N I +
Sbjct: 239 LDLNYNNLDEF-PTAIRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVG 297
Query: 307 PRTFKDLHFLEELQLGHNRIRQLAE-RSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVA 365
F+ L L L L N Q+ E G LE LTL Q+ + L N+
Sbjct: 298 RSAFQHLPELRTLTL--NGASQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQ 355
Query: 366 VMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGI 425
V++LS N L +LP F KL + L + + I+ TF L LR L L N + I
Sbjct: 356 VLDLSYNLLEDLPS--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAII 413
Query: 426 EEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468
+ L L++LDL+SN L+ P GL L +L L+ N
Sbjct: 414 HPNAFSTLPSLIKLDLSSNLLSSFP---ITGLHGLTHLKLTGN 453
Score = 106 bits (264), Expect = 7e-23
Identities = 68/206 (33%), Positives = 100/206 (48%), Gaps = 1/206 (0%)
Query: 315 FLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
F L L N I QL L LE L L N L + GAF GL ++ V+ L N L
Sbjct: 67 FTSYLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQL 126
Query: 375 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 434
R++P + + L L SL L+ + + + P F+GL LR L+L DN L I Q+ L+
Sbjct: 127 RHVPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLS 186
Query: 435 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
L + L N++ H+P F L L L L NR+ L L LD+++N L
Sbjct: 187 ALQAMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNL 246
Query: 495 EALPNSLLAPLGRLRYLSLRNNSLRT 520
+ P + + L L+ L +N++R+
Sbjct: 247 DEFPTA-IRTLSNLKELGFHSNNIRS 271
Score = 100 bits (250), Expect = 3e-21
Identities = 81/269 (30%), Positives = 122/269 (45%), Gaps = 4/269 (1%)
Query: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 329
+LDLS N ++ LL + P L L LRL+ NA+ + F L+ L+ L L +N++R +
Sbjct: 70 YLDLSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHV 129
Query: 330 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 389
+ + L L+ L LD N + V F GL ++ + L N L +P Q FR L L
Sbjct: 130 PTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQ 189
Query: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
++ L + + I + F LS L L L +N + + ++ GL L LDL N L
Sbjct: 190 AMTLALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEF 249
Query: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 509
P + + L L+ L N + +P A + N ++ + S L LR
Sbjct: 250 PTAI-RTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELR 308
Query: 510 YLSLRNNSLRTFTPQPPG---LERLWLEG 535
L+L S T P G LE L L G
Sbjct: 309 TLTLNGASQITEFPDLTGTANLESLTLTG 337
>gi|8394456 toll-like receptor 9 isoform A precursor [Homo sapiens]
Length = 1032
Score = 147 bits (371), Expect = 3e-35
Identities = 178/617 (28%), Positives = 251/617 (40%), Gaps = 111/617 (17%)
Query: 64 NLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLEN 123
NLT +P +P + L L N + + P NL++L L++ GG + +E
Sbjct: 210 NLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDV-GGNCRRCDHAPNPCME- 267
Query: 124 LCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL- 182
C H + L TF+H L L L ++ LS L F GLG+L L+L N L
Sbjct: 268 -CPRHFPQ-----LHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLY 321
Query: 183 -AVLPDAAFRGLGSLRELVLAGN---RLAYLQPAL---FSGLAELRELDLSRNALRAIKA 235
+ AF+GL LR+L L+ N R+++ +L F L L+ELD+ R++
Sbjct: 322 KCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDE 381
Query: 236 NVF---VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF------ 286
+LP LQ L L N I G F LR++DLS NR++G E T
Sbjct: 382 TTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEAD 441
Query: 287 --------PGLLGLR-------------------VLRLSHNAIASLRPRTFKDLHFLEEL 319
PG L L LS N + +++P F L L+ L
Sbjct: 442 GGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCL 501
Query: 320 QLGHNRIRQLAERS-FEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN------ 372
+L HN I Q S F L L+VL L HN+L +F L + ++LS N
Sbjct: 502 RLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGM 561
Query: 373 ---------------------CLRNLPEQVFRGL--GKLHSLHLEGSCLGR------IRP 403
N+ QV + L L +L G+ LG +
Sbjct: 562 QGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYL 621
Query: 404 HTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLE-LDLTSNQLTHLPHRLFQGLGKLEY 462
H F GLSGL L L N L + Q+L L + L+ L L N L L KLE
Sbjct: 622 HFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEV 681
Query: 463 LLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRT-- 520
L L+ N+L L +L R LDVS N + + + LR L+L N+L+T
Sbjct: 682 LDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVD 741
Query: 521 ---FTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYT 577
F P L+ L + NP C C A DF L+ +AVP
Sbjct: 742 HSWFGPLASALQILDVSANPLHCACG-AAFMDFLLEVQAAVPGLP--------------- 785
Query: 578 YNNITCASPPEVVGLDL 594
+ + C SP ++ GL +
Sbjct: 786 -SRVKCGSPGQLQGLSI 801
Score = 103 bits (258), Expect = 3e-22
Identities = 144/545 (26%), Positives = 205/545 (37%), Gaps = 139/545 (25%)
Query: 148 LASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAV------------LPDAAFRGLGS 195
+ SL LS+NR+ L D F L SL LNL WN V + + F + +
Sbjct: 65 VTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPT 124
Query: 196 LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL-- 253
L EL L+ N + + PAL L L LS + + + L L+ L++D N
Sbjct: 125 LEELNLSYNNIMTV-PALPKSLI---SLSLSHTNILMLDSASLAGLHALRFLFMDGNCYY 180
Query: 254 ------IAAVAPGAFLGL---------------------KALRWLDLSHNRVAGLLEDTF 286
VAPGA LGL +L +L LS+NR+ L +
Sbjct: 181 KNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDL 240
Query: 287 PGLLGLRVLRLSHNA----------------IASLRPRTFKDLHFLEELQLGHNRIRQLA 330
L LRVL + N L P TF L LE L L + + L
Sbjct: 241 ANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLN 300
Query: 331 ERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLTNVAVMNLS------------------ 370
F GLG L VL L N L + K AF GLT + +NLS
Sbjct: 301 ASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSF 360
Query: 371 ------------GNCLRNLPEQVFRGLGK---LHSLHLEGSCLGRIRPHTFTGLSGLRRL 415
G R+L E R L + L +L L+ + + + + F GLR +
Sbjct: 361 GSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYV 420
Query: 416 FLKDNGLVGIEE-----------QSLW----GLAEL------------------LELDLT 442
L DN + G E + +W LA LDL+
Sbjct: 421 DLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLS 480
Query: 443 SNQLTHLPHRLFQGLGKLEYLLLSRNRLAE-LPADALGPLQRAFWLDVSHNRLEALPNSL 501
N L + +F L L+ L LS N +++ + PL LD+SHN+L+
Sbjct: 481 RNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHS 540
Query: 502 LAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRF 561
L RL L L NS QP G++ + G+ + L+ LR +L + + +
Sbjct: 541 FTELPRLEALDLSYNS------QPFGMQGV---GHNFSFVAHLRTLRHLSLAHNNIHSQV 591
Query: 562 VQAIC 566
Q +C
Sbjct: 592 SQQLC 596
Score = 44.7 bits (104), Expect = 3e-04
Identities = 53/201 (26%), Positives = 79/201 (39%), Gaps = 35/201 (17%)
Query: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSC 397
G + L+L N++ + F L ++ +NL NC P GL +H C
Sbjct: 63 GNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNC----PPV---GLSPMHF-----PC 110
Query: 398 LGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL 457
I P TF + L L L N ++ + L+ L L+ + L GL
Sbjct: 111 HMTIEPSTFLAVPTLEELNLSYNNIMTVPALP----KSLISLSLSHTNILMLDSASLAGL 166
Query: 458 GKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNS 517
L +L + N ++ + LE P +LL LG L +LSL+ N+
Sbjct: 167 HALRFLFMDGN---------------CYYKNPCRQALEVAPGALLG-LGNLTHLSLKYNN 210
Query: 518 LRTFTPQ--PPGLERLWLEGN 536
L T P+ P LE L L N
Sbjct: 211 L-TVVPRNLPSSLEYLLLSYN 230
>gi|193083139 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 146 bits (368), Expect = 6e-35
Identities = 172/558 (30%), Positives = 234/558 (41%), Gaps = 90/558 (16%)
Query: 58 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 117
V C L ++P +P T+ L L GN L S+ + ++L L+L ++ L+P A
Sbjct: 33 VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92
Query: 118 LLGLENLCHLHLERNQL---RSLALGTFAHTPALASLGLSNNRL-SRLEDGLFEGLGSLW 173
L +L HL L N+L +L+ G P + SL LS N L S L + L SL
Sbjct: 93 FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
Query: 174 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 233
L+L NSL L FR + +L +L L N L ++ F GL L L+LSRN+L I
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
Query: 234 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLK-ALRWLDLSHNRVAGLLEDTFPGLLGL 292
L +L+ L L N I A + + L WLDL N++ FP L L
Sbjct: 213 SD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLL-----HFPDLAAL 264
Query: 293 R---VLRLSHNAI--ASLRPRTFKDLH--------------------------------- 314
L LS+N I + P+ K +H
Sbjct: 265 PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
Query: 315 ---------FLEE------LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL 359
FLE L L N +R R L L +L L HN L+ ++ GA
Sbjct: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-R 383
Query: 360 GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLS 410
L ++ + L GN LR+LP F L L L+L+G+ C G P F+G++
Sbjct: 384 ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGIT 443
Query: 411 GLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNR 469
LR L L DN + + + L ELDL+SN + GL LE L L N
Sbjct: 444 SLRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNG 502
Query: 470 LAELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG 527
L L D L+R L+++ NRL LP A L L LRNNS G
Sbjct: 503 LMVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMG 557
Query: 528 -----LERLWLEGNPWDC 540
L RL+L+GNP C
Sbjct: 558 GLETSLRRLYLQGNPLSC 575
Score = 100 bits (248), Expect = 5e-21
Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)
Query: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330
LDLS N++ +L LR L LS N I+ L+P F+ L LE L L HNR+
Sbjct: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
Query: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 389
S GLG L V ++LSGN L L E++ LH
Sbjct: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
Query: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
+L L + L R+ HTF + L +L L N L+ IE+ + GL L L+L+ N LT +
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
Query: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 508
Q +L L LS N + + + + WLD+ N+L P+ LA L RL
Sbjct: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267
Query: 509 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 546
YL+L NN +R T P + + W PL A
Sbjct: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304
>gi|5031707 leucine rich repeat containing 32 precursor [Homo
sapiens]
Length = 662
Score = 146 bits (368), Expect = 6e-35
Identities = 172/558 (30%), Positives = 234/558 (41%), Gaps = 90/558 (16%)
Query: 58 VFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQA 117
V C L ++P +P T+ L L GN L S+ + ++L L+L ++ L+P A
Sbjct: 33 VSCQVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGA 92
Query: 118 LLGLENLCHLHLERNQL---RSLALGTFAHTPALASLGLSNNRL-SRLEDGLFEGLGSLW 173
L +L HL L N+L +L+ G P + SL LS N L S L + L SL
Sbjct: 93 FQALTHLEHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
Query: 174 DLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAI 233
L+L NSL L FR + +L +L L N L ++ F GL L L+LSRN+L I
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
Query: 234 KANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLK-ALRWLDLSHNRVAGLLEDTFPGLLGL 292
L +L+ L L N I A + + L WLDL N++ FP L L
Sbjct: 213 SD---FSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLL-----HFPDLAAL 264
Query: 293 R---VLRLSHNAI--ASLRPRTFKDLH--------------------------------- 314
L LS+N I + P+ K +H
Sbjct: 265 PRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
Query: 315 ---------FLEE------LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFL 359
FLE L L N +R R L L +L L HN L+ ++ GA
Sbjct: 325 NEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNALETLELGA-R 383
Query: 360 GLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGS----CLGRIRPH-----TFTGLS 410
L ++ + L GN LR+LP F L L L+L+G+ C G P F+G++
Sbjct: 384 ALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRVSPCGGPDEPGPSGCVAFSGIT 443
Query: 411 GLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGL-GKLEYLLLSRNR 469
LR L L DN + + + L ELDL+SN + GL LE L L N
Sbjct: 444 SLRSLSLVDNE-IELLRAGAFLHTPLTELDLSSNPGLEVATGALGGLEASLEVLALQGNG 502
Query: 470 LAELPAD--ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPG 527
L L D L+R L+++ NRL LP A L L LRNNS G
Sbjct: 503 LMVLQVDLPCFICLKR---LNLAENRLSHLPAWTQAV--SLEVLDLRNNSFSLLPGSAMG 557
Query: 528 -----LERLWLEGNPWDC 540
L RL+L+GNP C
Sbjct: 558 GLETSLRRLYLQGNPLSC 575
Score = 100 bits (248), Expect = 5e-21
Identities = 90/278 (32%), Positives = 124/278 (44%), Gaps = 29/278 (10%)
Query: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLA 330
LDLS N++ +L LR L LS N I+ L+P F+ L LE L L HNR+
Sbjct: 54 LDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMAT 113
Query: 331 ERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL-RNLPEQVFRGLGKLH 389
S GLG L V ++LSGN L L E++ LH
Sbjct: 114 ALSAGGLGP---------------------LPRVTSLDLSGNSLYSGLLERLLGEAPSLH 152
Query: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
+L L + L R+ HTF + L +L L N L+ IE+ + GL L L+L+ N LT +
Sbjct: 153 TLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCI 212
Query: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ-RAFWLDVSHNRLEALPNSLLAPLGRL 508
Q +L L LS N + + + + WLD+ N+L P+ LA L RL
Sbjct: 213 SDFSLQ---QLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPD--LAALPRL 267
Query: 509 RYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKA 546
YL+L NN +R T P + + W PL A
Sbjct: 268 IYLNLSNNLIRLPTGPPQDSKGIHAPSEGWS-ALPLSA 304
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 145 bits (365), Expect = 1e-34
Identities = 112/346 (32%), Positives = 160/346 (46%), Gaps = 8/346 (2%)
Query: 30 PGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 89
P P A G CPA C C+ A V C+ R LT +PDG+P T+ L L N + +
Sbjct: 16 PAAPPPAGG--CPARCECTVQTRA----VACTRRRLTAVPDGIPAETRLLELSRNRIRCL 69
Query: 90 PPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALA 149
P L +L L+L + +EP A L L L L NQL+ + G F L
Sbjct: 70 NPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVFTRLDNLT 129
Query: 150 SLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYL 209
L LS N+L L D F+ L SL L +G N L + AF GL +L EL L L L
Sbjct: 130 LLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLERCNLTAL 189
Query: 210 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDR-NLIAAVAPGAFLGLKAL 268
L L L L A+ +++ F +LP L L +D L+ VA G+ GL L
Sbjct: 190 SGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGSLRGLN-L 248
Query: 269 RWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQ 328
L ++H + + L L LSHN I+++ +F+DL L EL L +
Sbjct: 249 TSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHLAGALLAV 308
Query: 329 LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
+ ++F GL Q+ +L L +N L ++ F + + + + GN L
Sbjct: 309 VEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPL 354
Score = 120 bits (302), Expect = 3e-27
Identities = 115/384 (29%), Positives = 176/384 (45%), Gaps = 42/384 (10%)
Query: 218 AELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNR 277
AE R L+LSRN +R + LP L++L L N IA V PGAF L LR L L N+
Sbjct: 54 AETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQ 113
Query: 278 VAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGL 337
+ + F L L +L LS N + L TF+DLH L L++G N + ++ R+F GL
Sbjct: 114 LKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGL 173
Query: 338 GQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEG-S 396
LE LTL+ L + + L ++ + L + +L +Q FR L L L ++
Sbjct: 174 LALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWP 233
Query: 397 CLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQG 456
L + + GL+ L L + + + +L A L L+L+ N ++ +P F+
Sbjct: 234 LLEEVAAGSLRGLN-LTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRD 292
Query: 457 LGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNN 516
L +L L L+ LA + A L++ L++S+N L L S +
Sbjct: 293 LVRLRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTF-------------H 339
Query: 517 SLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAY 576
S+ T LE L ++GNP C C L + +Q + D + PA
Sbjct: 340 SVNT-------LETLRVDGNPLACDCRLL----WIVQRRKTL---------NFDGRLPA- 378
Query: 577 TYNNITCASPPEVVGLDLRDLSEA 600
CA+P EV G LR+L ++
Sbjct: 379 ------CATPAEVRGDALRNLPDS 396
Score = 80.1 bits (196), Expect = 5e-15
Identities = 56/179 (31%), Positives = 89/179 (49%)
Query: 77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136
+ L L+ NL+++ + +L SLG L L+ + SLE Q L L HL ++ L
Sbjct: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
Query: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
L SL +++ ++ + L LNL N ++ +P +FR L L
Sbjct: 237 EVAAGSLRGLNLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRL 296
Query: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 255
REL LAG LA ++P F GL ++R L+LS N L ++ + F + L+ L +D N +A
Sbjct: 297 RELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA 355
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 144 bits (363), Expect = 2e-34
Identities = 145/526 (27%), Positives = 236/526 (44%), Gaps = 59/526 (11%)
Query: 60 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119
CS LT++PD +P L L N L +P A F S L L++ + LEP+
Sbjct: 37 CSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQ 96
Query: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 179
L L L+L+ N+L L+ TFA L L L +N + ++++ F +L L+L
Sbjct: 97 KLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSH 156
Query: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA---LFSGLAELRELDLSRNALRAIKAN 236
N L+ L +L+EL+L+ N++ L+ +F+ + L++L+LS N ++
Sbjct: 157 NGLSSTKLGTQVQLENLQELLLSNNKIQALKSEELDIFAN-SSLKKLELSSNQIKEFSPG 215
Query: 237 VFVQLPRLQKLYLD---------------------RNL------IAAVAPGAFLGLK--A 267
F + RL L+L+ RNL ++ + FLGLK
Sbjct: 216 CFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTN 275
Query: 268 LRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIR 327
L LDLS+N + + D+F L L L +N I L + L + L L + +
Sbjct: 276 LTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTK 335
Query: 328 Q---------LAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN--CLRN 376
Q + + SF+ L LE L ++ N + +K+ F GL N+ ++LS + LR
Sbjct: 336 QSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRT 395
Query: 377 LPEQVFRGL--GKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL-VGIEEQSLWGL 433
L + F L LH L+L + + +I F+ L L L L N + + Q GL
Sbjct: 396 LTNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGL 455
Query: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPA--DALGPLQRAFWLDVSH 491
+ E+ L+ N+ L F + L+ L+L R L + + PL+ LD+S+
Sbjct: 456 ENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSN 515
Query: 492 NRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNP 537
N + + + +L L +L L L++N+ L RLW NP
Sbjct: 516 NNIANINDDMLEGLEKLEILDLQHNN----------LARLWKHANP 551
Score = 141 bits (356), Expect = 2e-33
Identities = 154/553 (27%), Positives = 234/553 (42%), Gaps = 79/553 (14%)
Query: 53 ADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGS 112
+D+ FC+ NLT L L N++ + F +L L+L L S
Sbjct: 115 SDKTFAFCT--NLTELH-----------LMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 161
Query: 113 LEPQALLGLENLCHLHLERNQLRSLA---LGTFAHTPALASLGLSNNRLSRLEDGLFEGL 169
+ + LENL L L N++++L L FA++ +L L LS+N++ G F +
Sbjct: 162 TKLGTQVQLENLQELLLSNNKIQALKSEELDIFANS-SLKKLELSSNQIKEFSPGCFHAI 220
Query: 170 GSLWDLNLGWNSLAVLPDAAFR-----GLGSLRELVLAGNRLAYLQPALFSGL--AELRE 222
G L+ L L N++ + P + S+R L L+ ++L+ F GL L
Sbjct: 221 GRLFGLFL--NNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTM 278
Query: 223 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA--------------------------- 255
LDLS N L + + F LP+L+ +L+ N I
Sbjct: 279 LDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSI 338
Query: 256 ------AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHN--AIASLRP 307
+ +F LK L L++ N + G+ + F GL+ L+ L LS++ ++ +L
Sbjct: 339 SLASLPKIDDFSFQWLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSFTSLRTLTN 398
Query: 308 RTFKDLHF--LEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL-QEVKAGAFLGLTNV 364
TF L L L L N+I ++ +F LG LEVL L N++ QE+ + GL N+
Sbjct: 399 ETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENI 458
Query: 365 AVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI--RPHTFTGLSGLRRLFLKDNGL 422
+ LS N L F + L L L L + P F L L L L +N +
Sbjct: 459 FEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNI 518
Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHL--------PHRLFQGLGKLEYLLLSRNRLAELP 474
I + L GL +L LDL N L L P +GL L L L N E+P
Sbjct: 519 ANINDDMLEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIP 578
Query: 475 ADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL-----RTFTPQPPGLE 529
+ L +D+ N L LP S+ L+ L+L+ N + + F P L
Sbjct: 579 VEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLT 638
Query: 530 RLWLEGNPWDCGC 542
L + NP+DC C
Sbjct: 639 ELDMRFNPFDCTC 651
Score = 116 bits (290), Expect = 7e-26
Identities = 122/429 (28%), Positives = 184/429 (42%), Gaps = 47/429 (10%)
Query: 98 SSLGFLNLQGGQLGSLEPQALLGLE--NLCHLHLERNQLRSLALGTFAHTPALASLGLSN 155
+S+ L+L QL + LGL+ NL L L N L + +FA P L L
Sbjct: 248 TSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEY 307
Query: 156 NRLSRLEDGLFEGLGSLWDLNLGWN------SLAVLP---DAAFRGLGSLRELVLAGNRL 206
N + L GL ++ LNL + SLA LP D +F+ L L L + N +
Sbjct: 308 NNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDI 367
Query: 207 AYLQPALFSGLAELRELDLSRN--ALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLG 264
++ +F+GL L+ L LS + +LR + FV L
Sbjct: 368 PGIKSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAH--------------------- 406
Query: 265 LKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIAS-LRPRTFKDLHFLEELQLGH 323
L L+L+ N+++ + D F L L VL L N I L + ++ L + E+ L +
Sbjct: 407 -SPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSY 465
Query: 324 NRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGA--FLGLTNVAVMNLSGNCLRNLPEQV 381
N+ QL SF + L+ L L L+ V + F L N+ +++LS N + N+ + +
Sbjct: 466 NKYLQLTRNSFALVPSLQRLMLRRVALKNVDSSPSPFQPLRNLTILDLSNNNIANINDDM 525
Query: 382 FRGLGKLHSLHLEGSCLGRIRPHT--------FTGLSGLRRLFLKDNGLVGIEEQSLWGL 433
GL KL L L+ + L R+ H GLS L L L+ NG I + L
Sbjct: 526 LEGLEKLEILDLQHNNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDL 585
Query: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFW-LDVSHN 492
EL +DL N L LP +F L+ L L +N + + GP R LD+ N
Sbjct: 586 FELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPAFRNLTELDMRFN 645
Query: 493 RLEALPNSL 501
+ S+
Sbjct: 646 PFDCTCESI 654
>gi|198041768 synleurin [Homo sapiens]
Length = 622
Score = 142 bits (359), Expect = 7e-34
Identities = 103/314 (32%), Positives = 155/314 (49%), Gaps = 1/314 (0%)
Query: 60 CSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALL 119
C + L+ +P P T L+L GNN+S + + L SL L L + + P+A +
Sbjct: 46 CRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFV 105
Query: 120 GLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGW 179
L +L L L N ++ L G F L +L L N++S + G+F L S+ LNL
Sbjct: 106 QLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQR 165
Query: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFV 239
N L VL F G+ +LR L L+ N + + + F L L L L N L + +N F
Sbjct: 166 NRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFE 225
Query: 240 QLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSH 299
L L++L L N I A+ P AF GL L +L L ++R+ + D F G+ L+ L LSH
Sbjct: 226 VLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSH 285
Query: 300 NAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG-QLEVLTLDHNQLQEVKAGAF 358
N + +L TF L L L+L NRI + +FE +G L++L L N L +
Sbjct: 286 NDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVL 345
Query: 359 LGLTNVAVMNLSGN 372
L+++ + + N
Sbjct: 346 KPLSSLIHLQANSN 359
Score = 142 bits (358), Expect = 9e-34
Identities = 111/374 (29%), Positives = 163/374 (43%), Gaps = 42/374 (11%)
Query: 223 LDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLL 282
L L+ N + I + L L LYLD + I V P AF+ L+ L +L L++N + L
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 283 EDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEV 342
F GLL LR L L +N ++ + F DL ++ L L NR+ L +F G+ L +
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
Query: 343 LTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIR 402
L L +N + + F L N+A + L N L +P F L L L L + + I+
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 403 PHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEY 462
P F GL+ L L LK++ + + G+ L L L+ N L +L F L L Y
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 463 LLLSRNRLAELPADALGPLQRAF-WLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTF 521
L L RNR+ + D + + L++S N L AL +L PL L +L +
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANS------ 358
Query: 522 TPQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNI 581
NPW+C C L LRD+ + + NI
Sbjct: 359 --------------NPWECNCKLLGLRDWLASSAITL---------------------NI 383
Query: 582 TCASPPEVVGLDLR 595
C +PP + G LR
Sbjct: 384 YCQNPPSMRGRALR 397
Score = 135 bits (341), Expect = 8e-32
Identities = 93/295 (31%), Positives = 151/295 (51%), Gaps = 1/295 (0%)
Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
L L N+++ + ++ GL SL L L + + Y+ P F L L L L+ N ++ +
Sbjct: 65 LYLTGNNISYINESELTGLHSLVALYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLD 124
Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
+F L L+ LYL N ++ V G F L ++++L+L NR+ L TF G++ LR+
Sbjct: 125 PGIFKGLLNLRNLYLQYNQVSFVPRGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRI 184
Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
L LS+N I + F+ L L L LG N + ++ +FE L L L+L HN ++ ++
Sbjct: 185 LDLSNNNILRISESGFQHLENLACLYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQ 244
Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRR 414
AF GL N+ + L + +RN+ F G+ L L L + L + TF+ L L
Sbjct: 245 PFAFKGLANLEYLLLKNSRIRNVTRDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIY 304
Query: 415 LFLKDNGLVGIEEQSLWGL-AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRN 468
L L N ++ I+ + + A L L+L+ N LT L R+ + L L +L + N
Sbjct: 305 LKLDRNRIISIDNDTFENMGASLKILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
Score = 134 bits (337), Expect = 2e-31
Identities = 105/331 (31%), Positives = 155/331 (46%), Gaps = 4/331 (1%)
Query: 118 LLGLENLCHLHLERN-QLRSLALGTFAHT--PALASLGLSNNRLSRLEDGLFEGLGSLWD 174
+LG ++C L R R+L L + + L L+ N +S + + GL SL
Sbjct: 29 ILGCSSVCQLCTGRQINCRNLGLSSIPKNFPESTVFLYLTGNNISYINESELTGLHSLVA 88
Query: 175 LNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIK 234
L L +++ + AF L L L L N + L P +F GL LR L L N + +
Sbjct: 89 LYLDNSNILYVYPKAFVQLRHLYFLFLNNNFIKRLDPGIFKGLLNLRNLYLQYNQVSFVP 148
Query: 235 ANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRV 294
VF L +Q L L RN + + G F+G+ ALR LDLS+N + + E F L L
Sbjct: 149 RGVFNDLVSVQYLNLQRNRLTVLGSGTFVGMVALRILDLSNNNILRISESGFQHLENLAC 208
Query: 295 LRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVK 354
L L N + + F+ L L L L HN I + +F+GL LE L L +++++ V
Sbjct: 209 LYLGSNNLTKVPSNAFEVLKSLRRLSLSHNPIEAIQPFAFKGLANLEYLLLKNSRIRNVT 268
Query: 355 AGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL-SGLR 413
F G+ N+ + LS N L NL F L L L L+ + + I TF + + L+
Sbjct: 269 RDGFSGINNLKHLILSHNDLENLNSDTFSLLKNLIYLKLDRNRIISIDNDTFENMGASLK 328
Query: 414 RLFLKDNGLVGIEEQSLWGLAELLELDLTSN 444
L L N L + + L L+ L+ L SN
Sbjct: 329 ILNLSFNNLTALHPRVLKPLSSLIHLQANSN 359
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 141 bits (356), Expect = 2e-33
Identities = 122/350 (34%), Positives = 170/350 (48%), Gaps = 21/350 (6%)
Query: 33 PGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPA 92
PG G +CPA C C+ A V C R L +P G+P T+ L L GN L +
Sbjct: 24 PG-GSGGSCPAVCDCTSQPQA----VLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQG 78
Query: 93 AFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLG 152
LS L L+L QL +LEP A GL++L L L+ N+LR + G F+ AL L
Sbjct: 79 MLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLD 138
Query: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVL--------AGN 204
L N++ DG F LGSL L +G N L + AF GL L L L G
Sbjct: 139 LRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGL 198
Query: 205 RLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLG 264
LA L PAL + LRELD+ R A++ QL L+ ++L +L A+ PG+ +G
Sbjct: 199 ALARL-PALVA--LRLRELDIGRLPAGALRG--LGQLKELE-IHLWPSL-EALDPGSLVG 251
Query: 265 LKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHN 324
L L L ++ ++ + L LRVL LS N I+++ R L L+EL+L
Sbjct: 252 LN-LSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGA 310
Query: 325 RIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
+ +A +F GL +L + N LQ ++ AF + + LSGN L
Sbjct: 311 CLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
Score = 137 bits (344), Expect = 4e-32
Identities = 108/301 (35%), Positives = 146/301 (48%), Gaps = 8/301 (2%)
Query: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 210
L LS NRL L+ G+ L L +L+L +N L+ L AF GL SL L L GNRL +
Sbjct: 65 LDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMG 124
Query: 211 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 270
P +FSGL+ L LDL N + F +L LQKL + N + VAPGAF GL L
Sbjct: 125 PGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLST 184
Query: 271 LDLSH---NRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLG-HNRI 326
L L + V GL P L+ LR+ L I L + L L+EL++ +
Sbjct: 185 LTLERCNLSTVPGLALARLPALVALRLRELD---IGRLPAGALRGLGQLKELEIHLWPSL 241
Query: 327 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 386
L S GL L L + L V A L+ + V++LS N + +P + L
Sbjct: 242 EALDPGSLVGL-NLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300
Query: 387 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQL 446
+L L L G+CL I H F GL+ L + DN L +EE + +L+ L L+ N L
Sbjct: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
Query: 447 T 447
T
Sbjct: 361 T 361
Score = 94.7 bits (234), Expect = 2e-19
Identities = 101/356 (28%), Positives = 149/356 (41%), Gaps = 63/356 (17%)
Query: 284 DTFPGLLGL--RVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLE 341
+ PG L L +L LS N + L+ L L+EL L +N++ L +F GL L
Sbjct: 52 EAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLL 111
Query: 342 VLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRI 401
L L N+L+ + G F GL+ + +++L N + + F LG L L + + L +
Sbjct: 112 TLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFV 171
Query: 402 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 461
P F GL+ L L L+ L + +L L L+ L L + LP +GLG+L+
Sbjct: 172 APGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLK 231
Query: 462 ------------------------YLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEAL 497
L ++R L+ +P AL L LD+S N + A+
Sbjct: 232 ELEIHLWPSLEALDPGSLVGLNLSSLAITRCNLSSVPFQALYHLSFLRVLDLSQNPISAI 291
Query: 498 PNSLLAPLGRLRYLSL------------------------RNNSLRTFT----PQPPGLE 529
P L+PL RL+ L L +N+L+T P P L
Sbjct: 292 PARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLV 351
Query: 530 RLWLEGNPWDCGCPLKAL------RDFALQNPS-AVPRFVQ--AICEGDDCQPPAY 576
L L GNP C C L L DF + P+ A P VQ ++ E D PP +
Sbjct: 352 TLRLSGNPLTCDCRLLWLLRLRRHLDFGMSPPACAGPHHVQGKSLKEFSDILPPGH 407
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 140 bits (354), Expect = 3e-33
Identities = 130/364 (35%), Positives = 176/364 (48%), Gaps = 12/364 (3%)
Query: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 190
R+ LR L L P + L + +L L LG + LNLG N L +P+
Sbjct: 26 RSNLRQLTLTAAGACPGAGADALESPASPQLV--LPANLGDIEALNLGNNGLEEVPEGLG 83
Query: 191 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLD 250
LGSLR LVL NR A L PA+ L ELD+S N L A+ A V L L+KL L
Sbjct: 84 SALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLS 143
Query: 251 RNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTF 310
N + A+ P L L LD+S NR+A L D+ L LR L + HN + + PR
Sbjct: 144 HNQLPAL-PAQLGALAHLEELDVSFNRLAH-LPDSLSCLSRLRTLDVDHNQLTAF-PRQL 200
Query: 311 KDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 370
L LEEL + NR+R L E L L++L L +L + AG F L ++ + L
Sbjct: 201 LQLVALEELDVSSNRLRGLPE-DISALRALKILWLSGAELGTLPAG-FCELASLESLMLD 258
Query: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 430
N L+ LP Q F L +L L+L + P L+GL L+L N L + +
Sbjct: 259 NNGLQALPAQ-FSCLQRLKMLNLSSNLFEEF-PAALLPLAGLEELYLSRNQLTSV-PSLI 315
Query: 431 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 490
GL LL L L +N++ +LP + + G LE L+L N++A LP D G L R +
Sbjct: 316 SGLGRLLTLWLDNNRIRYLPDSIVELTG-LEELVLQGNQIAVLP-DHFGQLSRVGLWKIK 373
Query: 491 HNRL 494
N L
Sbjct: 374 DNPL 377
Score = 117 bits (292), Expect = 4e-26
Identities = 114/331 (34%), Positives = 154/331 (46%), Gaps = 37/331 (11%)
Query: 210 QPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALR 269
Q L + L ++ L+L N L + + L L+ L L RN A + P L
Sbjct: 55 QLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLT 114
Query: 270 WLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQL 329
LD+SHNR+ L + L LR L LSHN + +L P L LEEL + NR+ L
Sbjct: 115 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPAL-PAQLGALAHLEELDVSFNRLAHL 173
Query: 330 AERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLH 389
+ S L +L L +DHNQL L L + +++S N LR LPE + L L
Sbjct: 174 PD-SLSCLSRLRTLDVDHNQLTAFPR-QLLQLVALEELDVSSNRLRGLPEDI-SALRALK 230
Query: 390 SLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHL 449
L L G+ LG + P F L+ L L L +NGL + Q
Sbjct: 231 ILWLSGAELGTL-PAGFCELASLESLMLDNNGLQALPAQ--------------------- 268
Query: 450 PHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 509
F L +L+ L LS N E PA AL PL L +S N+L ++P SL++ LGRL
Sbjct: 269 ----FSCLQRLKMLNLSSNLFEEFPA-ALLPLAGLEELYLSRNQLTSVP-SLISGLGRLL 322
Query: 510 YLSLRNNSLRTFTP----QPPGLERLWLEGN 536
L L NN +R + P + GLE L L+GN
Sbjct: 323 TLWLDNNRIR-YLPDSIVELTGLEELVLQGN 352
Score = 91.7 bits (226), Expect = 2e-18
Identities = 106/334 (31%), Positives = 144/334 (43%), Gaps = 38/334 (11%)
Query: 74 GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 133
G +AL L N L VP L SL L L+ + L P +L L + N+
Sbjct: 63 GDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR 122
Query: 134 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 193
L +L + L L LS+N+L L L L L +L++ +N LA LPD + L
Sbjct: 123 LTALGAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLPD-SLSCL 180
Query: 194 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANV---------------- 237
LR L + N+L P L L ELD+S N LR + ++
Sbjct: 181 SRLRTLDVDHNQLTAF-PRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 239
Query: 238 ------FVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPG--- 288
F +L L+ L LD N + A+ P F L+ L+ L+LS N L + FP
Sbjct: 240 GTLPAGFCELASLESLMLDNNGLQAL-PAQFSCLQRLKMLNLSSN-----LFEEFPAALL 293
Query: 289 -LLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDH 347
L GL L LS N + S+ P L L L L +NRIR L + E G LE L L
Sbjct: 294 PLAGLEELYLSRNQLTSV-PSLISGLGRLLTLWLDNNRIRYLPDSIVELTG-LEELVLQG 351
Query: 348 NQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQV 381
NQ+ V F L+ V + + N L P +V
Sbjct: 352 NQI-AVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
Score = 77.4 bits (189), Expect = 4e-14
Identities = 71/201 (35%), Positives = 92/201 (45%), Gaps = 10/201 (4%)
Query: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
L ++ +NL N L +PE + LG L L L + R+ P L L + N
Sbjct: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
Query: 421 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
L + + + L EL +L+L+ NQL LP +L L LE L +S NRLA LP D+L
Sbjct: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLP-DSLSC 179
Query: 481 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER---LWLEG-- 535
L R LDV HN+L A P LL L L L + +N LR L LWL G
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQLL-QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAE 238
Query: 536 -NPWDCG-CPLKALRDFALQN 554
G C L +L L N
Sbjct: 239 LGTLPAGFCELASLESLMLDN 259
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 140 bits (353), Expect = 3e-33
Identities = 120/421 (28%), Positives = 197/421 (46%), Gaps = 36/421 (8%)
Query: 153 LSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPA 212
LS+NRLS ++ L SL ++ L N L +P+ ++ L LAGNR+ + P
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVS-ANITLLSLAGNRIVEILPE 79
Query: 213 LFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLD 272
L LDLS N + ++ F L +L+ LYL+ N + ++ PG F L
Sbjct: 80 HLKEFQSLETLDLSSNNISELQT-AFPAL-QLKYLYLNSNRVTSMEPGYFDNLANT---- 133
Query: 273 LSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAER 332
L VL+L+ N I+++ P+ FK L L+ L+L N+I+ +
Sbjct: 134 -------------------LLVLKLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGL 173
Query: 333 SFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLH 392
+F+GLG L+ L + N + ++ GAF GL+N+ ++ L N L + + GL L LH
Sbjct: 174 TFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELH 233
Query: 393 LEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHR 452
L + + RI P + L L L N L +++ S GL+ L L + +N+++++
Sbjct: 234 LSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADC 293
Query: 453 LFQGLGKLEYLLLSRNRLAELPAD---ALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLR 509
F+GL L+ L L N ++ D A L + L + NR+ ++ L L
Sbjct: 294 AFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALE 353
Query: 510 YLSLRNNSLRTFT----PQPPGLERLWLEGNPWDCGCPLKALRDFALQNPSAVPRFVQAI 565
+L L +N++ + Q L++L L + C C LK L + +N FV A
Sbjct: 354 HLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN--NFQSFVNAS 411
Query: 566 C 566
C
Sbjct: 412 C 412
Score = 138 bits (347), Expect = 2e-32
Identities = 114/369 (30%), Positives = 180/369 (48%), Gaps = 30/369 (8%)
Query: 129 LERNQLRSLALGTFAHTPALASLGLSNNRL--------------------SRLEDGLFEG 168
L N+L + + +H +L + L+NN L +R+ + L E
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEH 80
Query: 169 L---GSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-LRELD 224
L SL L+L N+++ L AF L L+ L L NR+ ++P F LA L L
Sbjct: 81 LKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLK 138
Query: 225 LSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED 284
L+RN + AI +F +LP+LQ L L+RN I V F GL AL+ L + N V L++
Sbjct: 139 LNRNRISAIPPKMF-KLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDG 197
Query: 285 TFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLT 344
F GL + +L+L HN + + L L+EL L N I +++ ++E +L L
Sbjct: 198 AFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELD 257
Query: 345 LDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLG---RI 401
L N L + +FLGL+ + +++ N + + + FRGL L +L L+ + +
Sbjct: 258 LTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIED 317
Query: 402 RPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLE 461
F+GL LRRL L+ N + I +++ GL L LDL+ N + L F + KL+
Sbjct: 318 MNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQ 377
Query: 462 YLLLSRNRL 470
L L+ + L
Sbjct: 378 QLHLNTSSL 386
Score = 134 bits (337), Expect = 2e-31
Identities = 97/295 (32%), Positives = 155/295 (52%), Gaps = 6/295 (2%)
Query: 61 SSRNLTRLPDGVPG-GTQALWLDGNNLSSVPPAAFQNLSS-LGFLNLQGGQLGSLEPQAL 118
SS N++ L P + L+L+ N ++S+ P F NL++ L L L ++ ++ P+ +
Sbjct: 93 SSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPK-M 151
Query: 119 LGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLG 178
L L HL L RN+++++ TF AL SL + N +++L DG F GL ++ L L
Sbjct: 152 FKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLD 211
Query: 179 WNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVF 238
N+L + GL L+EL L+ N + + P + +L ELDL+ N L + + F
Sbjct: 212 HNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSF 271
Query: 239 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVL 295
+ L L L++ N ++ +A AF GL +L+ LDL +N ++ +ED F GL LR L
Sbjct: 272 LGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRL 331
Query: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQL 350
L N I S+ + F L LE L L N I L +F + +L+ L L+ + L
Sbjct: 332 ILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSL 386
Score = 97.1 bits (240), Expect = 4e-20
Identities = 79/269 (29%), Positives = 127/269 (47%), Gaps = 27/269 (10%)
Query: 272 DLSHNRVAGLLEDTFPGLLGLR-----------------------VLRLSHNAIASLRPR 308
DLSHNR++ + + L LR +L L+ N I + P
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPE 79
Query: 309 TFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN-VAVM 367
K+ LE L L N I +L + +F L QL+ L L+ N++ ++ G F L N + V+
Sbjct: 80 HLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVL 137
Query: 368 NLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEE 427
L+ N + +P ++F+ L +L L L + + + TF GL L+ L ++ NG+ + +
Sbjct: 138 KLNRNRISAIPPKMFK-LPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMD 196
Query: 428 QSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWL 487
+ WGL+ + L L N LT + GL L+ L LS+N + + DA Q+ L
Sbjct: 197 GAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSEL 256
Query: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNN 516
D++ N L L +S L L L + NN
Sbjct: 257 DLTFNHLSRLDDSSFLGLSLLNTLHIGNN 285
Score = 58.9 bits (141), Expect = 1e-08
Identities = 55/237 (23%), Positives = 100/237 (42%), Gaps = 31/237 (13%)
Query: 313 LHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLG--LTNVAVMNLS 370
L + L HNR+ + S L L + L++N+L+ + LG N+ +++L+
Sbjct: 13 LFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPN---LGPVSANITLLSLA 69
Query: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIE---- 426
GN + + + + L +L L + + ++ F L L+ L+L N + +E
Sbjct: 70 GNRIVEILPEHLKEFQSLETLDLSSNNISELQT-AFPALQ-LKYLYLNSNRVTSMEPGYF 127
Query: 427 --------------------EQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLS 466
++ L +L L+L N++ ++ FQGLG L+ L +
Sbjct: 128 DNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 187
Query: 467 RNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP 523
RN + +L A L L + HN L + L L L+ L L N++ +P
Sbjct: 188 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISP 244
Score = 32.0 bits (71), Expect = 1.7
Identities = 20/52 (38%), Positives = 26/52 (50%), Gaps = 3/52 (5%)
Query: 488 DVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT---PQPPGLERLWLEGN 536
D+SHNRL + S ++ L LR + L NN L T P + L L GN
Sbjct: 20 DLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGN 71
>gi|45505137 podocan [Homo sapiens]
Length = 661
Score = 140 bits (352), Expect = 4e-33
Identities = 156/531 (29%), Positives = 238/531 (44%), Gaps = 63/531 (11%)
Query: 25 LEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGN 84
L +PG PG A +CP C CS + D C +L P +P T L L N
Sbjct: 102 LSPEEPG-PGPA-AVSCPRDCACSQEGVVD-----CGGIDLREFPGDLPEHTNHLSLQNN 154
Query: 85 NLSSVPPAAFQNLSSLGFLNLQGGQLGS--LEPQALLGLENLCHLHLERNQLRSLALGTF 142
L + P L L LNLQ +L S L +A L NL +L+L N+L L
Sbjct: 155 QLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKL---TLAPR 211
Query: 143 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAV--LPDAAFRGLGSLRELV 200
AL S+ + N L+++ F +L + L N LA LPD F G ++ L+
Sbjct: 212 FLPNALISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSSNVEVLI 271
Query: 201 LAGNRLAY----LQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA- 255
L+ N L + L PAL+ +L L N L I F +L L++LYL N +
Sbjct: 272 LSSNFLRHVPKHLPPALY-------KLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD 324
Query: 256 -AVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLH 314
+ F L +L +LDLS N ++ + L+ +L L NAI S+ +
Sbjct: 325 EGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLV---LLHLEKNAIRSVDANVLTPIR 381
Query: 315 FLEELQLGHNRIRQ--LAERSFEGLGQLEVLTLDHNQLQEVKAG---------------A 357
LE L L N++R+ + +F+GL +L + L +N L+ V +G
Sbjct: 382 SLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSGLPRRVRTLMILHNQIT 441
Query: 358 FLGLTNVAV------MNLSGNCLRN--LPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGL 409
+G + A +NLS N + + + FR L L SL L G+ L + P +
Sbjct: 442 GIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSLDLSGNRLHTLPPGLPRNV 501
Query: 410 SGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTH--LPHRLFQGLGKLEYLLLSR 467
L+ +K N L + +L G+A+L EL LTSN+L L R + L L+ L ++
Sbjct: 502 HVLK---VKRNELAALARGALVGMAQLRELYLTSNRLRSRALGPRAWVDLAHLQLLDIAG 558
Query: 468 NRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
N+L E+P L+ +L + +N++ A+P + L+ + LR N L
Sbjct: 559 NQLTEIPEGLPESLE---YLYLQNNKISAVPANAFDSTPNLKGIFLRFNKL 606
Score = 109 bits (273), Expect = 6e-24
Identities = 116/394 (29%), Positives = 178/394 (45%), Gaps = 46/394 (11%)
Query: 61 SSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLG 120
SS L +P +P L L N L +PP AF LSSL L LQ L G
Sbjct: 273 SSNFLRHVPKHLPPALYKLHLKNNKLEKIPPGAFSELSSLRELYLQNNYLTD------EG 326
Query: 121 LENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWN 180
L+N TF +L L LS+N LSR+ GL SL L+L N
Sbjct: 327 LDN----------------ETFWKLSSLEYLDLSSNNLSRVPAGLPR---SLVLLHLEKN 367
Query: 181 SLAVLPDAAFRGLGSLRELVLAGNRLAY--LQPALFSGLAELRELDLSRNALRAIKANVF 238
++ + + SL L+L N+L + P F GL L + L NAL + +
Sbjct: 368 AIRSVDANVLTPIRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERVPSG-- 425
Query: 239 VQLP-RLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG--LLEDTFPGLLGLRVL 295
LP R++ L + N I + F L L+LS+NR+ + D F L LR L
Sbjct: 426 --LPRRVRTLMILHNQITGIGREDFATTYFLEELNLSYNRITSPQVHRDAFRKLRLLRSL 483
Query: 296 RLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKA 355
LS N + +L P +++H L++ N + LA + G+ QL L L N+L+
Sbjct: 484 DLSGNRLHTLPPGLPRNVHV---LKVKRNELAALARGALVGMAQLRELYLTSNRLRSRAL 540
Query: 356 G--AFLGLTNVAVMNLSGNCLRNLPEQVFRGLGK-LHSLHLEGSCLGRIRPHTFTGLSGL 412
G A++ L ++ +++++GN L +PE GL + L L+L+ + + + + F L
Sbjct: 541 GPRAWVDLAHLQLLDIAGNQLTEIPE----GLPESLEYLYLQNNKISAVPANAFDSTPNL 596
Query: 413 RRLFLKDNGLV--GIEEQSLWGLAELLELDLTSN 444
+ +FL+ N L + + + L L LD+ N
Sbjct: 597 KGIFLRFNKLAVGSVVDSAFRRLKHLQVLDIEGN 630
Score = 97.4 bits (241), Expect = 3e-20
Identities = 90/292 (30%), Positives = 145/292 (49%), Gaps = 20/292 (6%)
Query: 247 LYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVA--GLLEDTFPGLLGLRVLRLSHNAIAS 304
L L N + + P L L L+L +NR+ GL E F L L L L++N + +
Sbjct: 149 LSLQNNQLEKIYPEELSRLHRLETLNLQNNRLTSRGLPEKAFEHLTNLNYLYLANNKL-T 207
Query: 305 LRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQE--VKAGAFLGLT 362
L PR + L + N + ++ +F L + L +N+L + + F G +
Sbjct: 208 LAPRFLPNA--LISVDFAANYLTKIYGLTFGQKPNLRSVYLHNNKLADAGLPDNMFNGSS 265
Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
NV V+ LS N LR++P+ + L KLH L+ + L +I P F+ LS LR L+L++N L
Sbjct: 266 NVEVLILSSNFLRHVPKHLPPALYKLH---LKNNKLEKIPPGAFSELSSLRELYLQNNYL 322
Query: 423 V--GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
G++ ++ W L+ L LDL+SN L+ +P L + L L L +N + + A+ L P
Sbjct: 323 TDEGLDNETFWKLSSLEYLDLSSNNLSRVPAGLPRSLVLLH---LEKNAIRSVDANVLTP 379
Query: 481 LQRAFWLDVSHNRL--EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER 530
++ +L + N+L + + L RL + L NN+L P GL R
Sbjct: 380 IRSLEYLLLHSNQLREQGIHPLAFQGLKRLHTVHLYNNALERV---PSGLPR 428
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 136 bits (342), Expect = 6e-32
Identities = 103/334 (30%), Positives = 160/334 (47%), Gaps = 4/334 (1%)
Query: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
CPA C CS A SV C R L +P+G+P T+ L L N L SV P F + L
Sbjct: 28 CPARCECS----AQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKSVNPEEFISYPLL 83
Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
++L + ++EP A L NL L L+ N+L+ + LG F L L +S N++
Sbjct: 84 EEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNLTKLDISENKIVI 143
Query: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
L D +F+ L +L L +G N L + AF GL SL +L L L + S L L
Sbjct: 144 LLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTAVPTEALSHLRSL 203
Query: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
L L + + F +L L+ L +D + + P L L L +++ ++
Sbjct: 204 ISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLDMMPANSLYGLNLTSLSVTNTNLST 263
Query: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
+ F L+ L L LS+N I+++ F DL L+EL + ++R + SF+GL L
Sbjct: 264 VPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFL 323
Query: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL 374
VL + N L+ ++ F + V++++ N L
Sbjct: 324 RVLNVSQNLLETLEENVFSSPRALEVLSINNNPL 357
Score = 122 bits (305), Expect = 1e-27
Identities = 102/330 (30%), Positives = 150/330 (45%), Gaps = 28/330 (8%)
Query: 219 ELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRV 278
E + LDLS+N L+++ F+ P L+++ L N+IA V PGAF L LR L L NR+
Sbjct: 58 ETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRL 117
Query: 279 AGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLG 338
+ F GL L L +S N I L F+DLH L+ L++G N + ++ R+F GL
Sbjct: 118 KLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLL 177
Query: 339 QLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCL 398
LE LTL+ L V A L ++ ++L + N+P F+ L L L ++ L
Sbjct: 178 SLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPL 237
Query: 399 GRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLG 458
+ P SL+GL L L +T+ L+ +P F+ L
Sbjct: 238 LDMMP-----------------------ANSLYGL-NLTSLSVTNTNLSTVPFLAFKHLV 273
Query: 459 KLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
L +L LS N ++ + A L R L + +L + L LR L++ N L
Sbjct: 274 YLTHLNLSYNPISTIEAGMFSDLIRLQELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLL 333
Query: 519 RTFTPQ----PPGLERLWLEGNPWDCGCPL 544
T P LE L + NP C C L
Sbjct: 334 ETLEENVFSSPRALEVLSINNNPLACDCRL 363
Score = 76.3 bits (186), Expect = 8e-14
Identities = 55/179 (30%), Positives = 92/179 (51%)
Query: 77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136
+ L L+ NL++VP A +L SL L+L+ + ++ A L +L HL ++ L
Sbjct: 180 EQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWPLLD 239
Query: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
+ + L SL ++N LS + F+ L L LNL +N ++ + F L L
Sbjct: 240 MMPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRL 299
Query: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA 255
+EL + G +L ++P F GL LR L++S+N L ++ NVF L+ L ++ N +A
Sbjct: 300 QELHIVGAQLRTIEPHSFQGLRFLRVLNVSQNLLETLEENVFSSPRALEVLSINNNPLA 358
>gi|7662320 leucine-rich repeats and immunoglobulin-like domains 2
[Homo sapiens]
Length = 1065
Score = 136 bits (342), Expect = 6e-32
Identities = 104/328 (31%), Positives = 163/328 (49%), Gaps = 7/328 (2%)
Query: 123 NLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
N+ L L N + + PAL SL LS+N +S ++ F + L LNL N +
Sbjct: 121 NITLLSLVHNIIPEINAQALQFYPALESLDLSSNIISEIKTSSFPRM-QLKYLNLSNNRI 179
Query: 183 AVLPDAAFRGLGS-LRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQL 241
L F L S L + L NR++ + P +F L L+ L+L RN ++ ++ F L
Sbjct: 180 TTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFK-LPHLQFLELKRNRIKIVEGLTFQGL 238
Query: 242 PRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA 301
L+ L + RN I+ + GAF GL + L+L HN + + + GL L+ L +S NA
Sbjct: 239 DSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLYVSQNA 298
Query: 302 IASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGL 361
I + P ++ L EL L +N++ +L E +F GL LE L L N++ + G F L
Sbjct: 299 IERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADGVFRFL 358
Query: 362 TNVAVMNLSGNCLRNLPE---QVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLK 418
+N+ ++L N + E + F GL L L L+G+ + I F GL L L L
Sbjct: 359 SNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLEHLDLN 418
Query: 419 DNGLVGIEEQSLWGLAELLELDLTSNQL 446
+N ++ I+E + + L EL L ++ L
Sbjct: 419 NNAIMSIQENA-FSQTHLKELILNTSSL 445
Score = 129 bits (324), Expect = 8e-30
Identities = 111/414 (26%), Positives = 194/414 (46%), Gaps = 34/414 (8%)
Query: 195 SLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLI 254
+L+E+ + N L + P + + L L N + I A P L+ L L N+I
Sbjct: 98 TLQEVKMNYNELTEI-PYFGEPTSNITLLSLVHNIIPEINAQALQFYPALESLDLSSNII 156
Query: 255 AAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLG-LRVLRLSHNAIASLRPRTFKDL 313
+ + +F ++ L++L+LS+NR+ L F L L V++L+ N ++ + P+ FK
Sbjct: 157 SEIKTSSFPRMQ-LKYLNLSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLP 215
Query: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373
H L+ L+L NRI+ + +F+GL L L + N + ++K GAF GL N+ + L N
Sbjct: 216 H-LQFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNN 274
Query: 374 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGL 433
L + + GL L L++ + + RI P + L L L N L ++E + GL
Sbjct: 275 LTRVNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGL 334
Query: 434 AELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLA---ELPADALGPLQRAFWLDVS 490
+ L L+L N++TH+ +F+ L L+ L L N ++ E ++A L L +
Sbjct: 335 SLLERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQ 394
Query: 491 HNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTP---QPPGLERLWLEGNPWDCGCPLKAL 547
N+++++ L L +L L NN++ + L+ L L + C C LK L
Sbjct: 395 GNQIKSITKKAFIGLESLEHLDLNNNAIMSIQENAFSQTHLKELILNTSSLLCDCHLKWL 454
Query: 548 RDFALQNPSAVPRFVQAICEGDDCQPPAYTYNNITCASP-----PEVVGLDLRD 596
+ + N F ++ N++CA P ++ +DL+D
Sbjct: 455 LQWLVDN-----NFQHSV--------------NVSCAHPEWLAGQSILNVDLKD 489
Score = 121 bits (304), Expect = 2e-27
Identities = 83/257 (32%), Positives = 129/257 (50%), Gaps = 3/257 (1%)
Query: 81 LDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALG 140
L N ++++ F NLSS + S+ P + L +L L L+RN+++ +
Sbjct: 174 LSNNRITTLEAGCFDNLSSSLLVVKLNRNRMSMIPPKIFKLPHLQFLELKRNRIKIVEGL 233
Query: 141 TFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELV 200
TF +L SL + N +S+L+DG F GL ++ +L L N+L + GL L++L
Sbjct: 234 TFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTRVNKGWLYGLRMLQQLY 293
Query: 201 LAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPG 260
++ N + + P + L ELDLS N L + + FV L L++L L N + +A G
Sbjct: 294 VSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLLERLNLGDNRVTHIADG 353
Query: 261 AFLGLKALRWLDLSHNRVAGLLED---TFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLE 317
F L L+ LDL +N ++ +ED F GL L L L N I S+ + F L LE
Sbjct: 354 VFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAFIGLESLE 413
Query: 318 ELQLGHNRIRQLAERSF 334
L L +N I + E +F
Sbjct: 414 HLDLNNNAIMSIQENAF 430
Score = 104 bits (260), Expect = 2e-22
Identities = 72/213 (33%), Positives = 106/213 (49%), Gaps = 3/213 (1%)
Query: 77 QALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRS 136
Q L L N + V FQ L SL L +Q + L+ A GL N+ L LE N L
Sbjct: 218 QFLELKRNRIKIVEGLTFQGLDSLRSLKMQRNGISKLKDGAFFGLNNMEELELEHNNLTR 277
Query: 137 LALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSL 196
+ G L L +S N + R+ +E L +L+L +N L L ++AF GL L
Sbjct: 278 VNKGWLYGLRMLQQLYVSQNAIERISPDAWEFCQRLSELDLSYNQLTRLDESAFVGLSLL 337
Query: 197 RELVLAGNRLAYLQPALFSGLAELRELDLSRNALR-AIK--ANVFVQLPRLQKLYLDRNL 253
L L NR+ ++ +F L+ L+ LDL N + AI+ + F L L KL L N
Sbjct: 338 ERLNLGDNRVTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQ 397
Query: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTF 286
I ++ AF+GL++L LDL++N + + E+ F
Sbjct: 398 IKSITKKAFIGLESLEHLDLNNNAIMSIQENAF 430
Score = 45.1 bits (105), Expect = 2e-04
Identities = 33/87 (37%), Positives = 47/87 (54%), Gaps = 6/87 (6%)
Query: 65 LTRLPDGV---PGGTQALWLDGNNLS-SVPPA--AFQNLSSLGFLNLQGGQLGSLEPQAL 118
+T + DGV Q L L N +S ++ A AF L+SL L LQG Q+ S+ +A
Sbjct: 347 VTHIADGVFRFLSNLQTLDLRNNEISWAIEDASEAFAGLTSLTKLILQGNQIKSITKKAF 406
Query: 119 LGLENLCHLHLERNQLRSLALGTFAHT 145
+GLE+L HL L N + S+ F+ T
Sbjct: 407 IGLESLEHLDLNNNAIMSIQENAFSQT 433
>gi|13194201 reticulon 4 receptor precursor [Homo sapiens]
Length = 473
Score = 131 bits (329), Expect = 2e-30
Identities = 89/237 (37%), Positives = 125/237 (52%), Gaps = 4/237 (1%)
Query: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
CP ACVC Y++ +++ C + L +P G+P +Q ++L GN +S VP A+F+ +L
Sbjct: 27 CPGACVC-YNEP--KVTTSCPQQGLQAVPVGIPAASQRIFLHGNRISHVPAASFRACRNL 83
Query: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERN-QLRSLALGTFAHTPALASLGLSNNRLS 159
L L L ++ A GL L L L N QLRS+ TF L +L L L
Sbjct: 84 TILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATFHGLGRLHTLHLDRCGLQ 143
Query: 160 RLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 219
L GLF GL +L L L N+L LPD FR LG+L L L GNR++ + F GL
Sbjct: 144 ELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLHGNRISSVPERAFRGLHS 203
Query: 220 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 276
L L L +N + + + F L RL LYL N ++A+ A L+AL++L L+ N
Sbjct: 204 LDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEALAPLRALQYLRLNDN 260
Score = 126 bits (316), Expect = 7e-29
Identities = 81/232 (34%), Positives = 115/232 (49%), Gaps = 21/232 (9%)
Query: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC-LR 375
+ + L NRI + SF L +L L N L + A AF GL + ++LS N LR
Sbjct: 60 QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
Query: 376 NLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAE 435
++ F GLG+LH+LHL+ L + P F GL+ L+ L+L+DN L + + + L
Sbjct: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
Query: 436 LLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLE 495
L L L N+++ +P R F+GL L+ LLL +NR+A + A L R L + N L
Sbjct: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
Query: 496 ALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKAL 547
ALP LAPL L+YL L + NPW C C + L
Sbjct: 240 ALPTEALAPLRALQYLRLND--------------------NPWVCDCRARPL 271
Score = 109 bits (273), Expect = 6e-24
Identities = 75/194 (38%), Positives = 104/194 (53%), Gaps = 1/194 (0%)
Query: 180 NSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNA-LRAIKANVF 238
N ++ +P A+FR +L L L N LA + A F+GLA L +LDLS NA LR++ F
Sbjct: 67 NRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLRSVDPATF 126
Query: 239 VQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLS 298
L RL L+LDR + + PG F GL AL++L L N + L +DTF L L L L
Sbjct: 127 HGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGNLTHLFLH 186
Query: 299 HNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAF 358
N I+S+ R F+ LH L+ L L NR+ + +F LG+L L L N L + A
Sbjct: 187 GNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLSALPTEAL 246
Query: 359 LGLTNVAVMNLSGN 372
L + + L+ N
Sbjct: 247 APLRALQYLRLNDN 260
Score = 91.3 bits (225), Expect = 2e-18
Identities = 68/201 (33%), Positives = 96/201 (47%), Gaps = 1/201 (0%)
Query: 245 QKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNA-IA 303
Q+++L N I+ V +F + L L L N +A + F GL L L LS NA +
Sbjct: 60 QRIFLHGNRISHVPAASFRACRNLTILWLHSNVLARIDAAAFTGLALLEQLDLSDNAQLR 119
Query: 304 SLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTN 363
S+ P TF L L L L +++L F GL L+ L L N LQ + F L N
Sbjct: 120 SVDPATFHGLGRLHTLHLDRCGLQELGPGLFRGLAALQYLYLQDNALQALPDDTFRDLGN 179
Query: 364 VAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLV 423
+ + L GN + ++PE+ FRGL L L L + + + PH F L L L+L N L
Sbjct: 180 LTHLFLHGNRISSVPERAFRGLHSLDRLLLHQNRVAHVHPHAFRDLGRLMTLYLFANNLS 239
Query: 424 GIEEQSLWGLAELLELDLTSN 444
+ ++L L L L L N
Sbjct: 240 ALPTEALAPLRALQYLRLNDN 260
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 130 bits (326), Expect = 5e-30
Identities = 114/418 (27%), Positives = 172/418 (41%), Gaps = 24/418 (5%)
Query: 40 ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSS 99
ACPA C C+ +V C L +P +P T+ L L+GNN++ + F L
Sbjct: 33 ACPALCTCT------GTTVDCHGTGLQAIPKNIPRNTERLELNGNNITRIHKNDFAGLKQ 86
Query: 100 LGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLS 159
L L L Q+G++E A ++ L L L RNQL L F + AL+ L LS N +
Sbjct: 87 LRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQ 146
Query: 160 RLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE 219
+ F G L +L L N ++ + + AFR L L L L N + + + F+ + +
Sbjct: 147 AIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPK 206
Query: 220 LRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIA----AVAPGAFLGLKALR----WL 271
LR L N L L L + R I P + GL
Sbjct: 207 LRTFRLHSNHLFC-----DCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEF 261
Query: 272 DLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL-----HFLEELQLGHNRI 326
S AG + + N I R + + + E++L N I
Sbjct: 262 SCSGQGEAGRVPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIPANLPETMTEIRLELNGI 321
Query: 327 RQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLG 386
+ + +F +L + L +NQ+ E+ AF GL ++ + L GN + +LP VF GL
Sbjct: 322 KSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLY 381
Query: 387 KLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSN 444
L L L + + IRP F L L L L DN + + + + L + L L N
Sbjct: 382 TLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQN 439
Score = 124 bits (310), Expect = 3e-28
Identities = 118/421 (28%), Positives = 175/421 (41%), Gaps = 44/421 (10%)
Query: 151 LGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQ 210
L L+ N ++R+ F GL L L L N + + AF + L L L N+L L
Sbjct: 66 LELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHMLP 125
Query: 211 PALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRW 270
LF L LDLS NA++AI F L+ L LD+N I+ + GAF L+ L
Sbjct: 126 ELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGLEV 185
Query: 271 LDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAI------------ASLRPRTFKDLHFLEE 318
L L++N + + +F + LR RL N + RP
Sbjct: 186 LTLNNNNITTIPVSSFNHMPKLRTFRLHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGP 245
Query: 319 LQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCL---- 374
L + ++ + F GQ E + L A +N +++ G L
Sbjct: 246 ASLRGLNVAEVQKSEFSCSGQGEAGRVPTCTLSSGSCPAMCTCSN-GIVDCRGKGLTAIP 304
Query: 375 RNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLA 434
NLPE + + LE + + I P F+ LRR+ L +N + I + GL
Sbjct: 305 ANLPE-------TMTEIRLELNGIKSIPPGAFSPYRKLRRIDLSNNQIAEIAPDAFQGLR 357
Query: 435 ELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRL 494
L L L N++T LP +F GL L+ LLL+ N++ + DA LQ L + N++
Sbjct: 358 SLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKI 417
Query: 495 EALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLERLWLEGNPWDCGCPLKALRDFALQN 554
++L + SLR ++ L L NP+ C C LK L DF N
Sbjct: 418 QSLAKG--------TFTSLR------------AIQTLHLAQNPFICDCNLKWLADFLRTN 457
Query: 555 P 555
P
Sbjct: 458 P 458
Score = 111 bits (278), Expect = 2e-24
Identities = 152/613 (24%), Positives = 235/613 (38%), Gaps = 121/613 (19%)
Query: 40 ACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSS 99
+CPA C CS V C + LT +P +P + L+ N + S+PP AF
Sbjct: 281 SCPAMCTCSNG------IVDCRGKGLTAIPANLPETMTEIRLELNGIKSIPPGAFSPYRK 334
Query: 100 LGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGT------------------ 141
L ++L Q+ + P A GL +L L L N++ L G
Sbjct: 335 LRRIDLSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVFGGLYTLQLLLLNANKIN 394
Query: 142 ------FAHTPALASLGLSNNRLSRLEDGLFEGLGSLW-----------DLNLGW--NSL 182
F L+ L L +N++ L G F L ++ D NL W + L
Sbjct: 395 CIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLAQNPFICDCNLKWLADFL 454
Query: 183 AVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAE-------LRELDLSRNALRAI-- 233
P G LA R+ ++ F A+ + L+ +
Sbjct: 455 RTNPIET-SGARCASPRRLANKRIGQIKSKKFRCSAKEQYFIPGTEDYQLNSECNSDVVC 513
Query: 234 ------KANV-------FVQLPR-----LQKLYLDRNLIAAV-APGAFLGLKALRWLDLS 274
+ANV ++P +L L+ N I+ + A G F L L+ ++LS
Sbjct: 514 PHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISILEATGMFKKLTHLKKINLS 573
Query: 275 HNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSF 334
+N+V+ + + F G + L L+ N + S+R F+ L L L L +NRI + SF
Sbjct: 574 NNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGLRTLMLRNNRISCIHNDSF 633
Query: 335 EGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGN---------------------- 372
GL + +L+L NQ+ V GAF L +++ +NL N
Sbjct: 634 TGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNCNCQLAWLGGWLRKRKIVT 693
Query: 373 ---------CLRNLPEQ--VFRGLGKLHSLHLEGSCLGRIR-PHTFTGLSGLRRLFLKDN 420
LR +P Q F + EG CL R + P L + R K
Sbjct: 694 GNPRCQNPDFLRQIPLQDVAFPDF-RCEEGQEEGGCLPRPQCPQECACLDTVVRCSNKHL 752
Query: 421 GLV--GIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADAL 478
+ GI + + EL L NQ T +P +L L+ + LS N+++ L +
Sbjct: 753 RALPKGIPKN-------VTELYLDGNQFTLVPGQL-STFKYLQLVDLSNNKISSLSNSSF 804
Query: 479 GPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFT----PQPPGLERLWLE 534
+ + L +S+N L+ +P L LR LSL N + T L L +
Sbjct: 805 TNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIG 864
Query: 535 GNPWDCGCPLKAL 547
NP C C L+ L
Sbjct: 865 ANPLYCDCHLRWL 877
Score = 110 bits (275), Expect = 4e-24
Identities = 106/374 (28%), Positives = 158/374 (42%), Gaps = 54/374 (14%)
Query: 30 PGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSV 89
PGT C + VC + + V CSS LT++P+ +P T L L+ N +S +
Sbjct: 496 PGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERIPQSTAELRLNNNEISIL 555
Query: 90 PPAA-FQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPAL 148
F+ L+ L +NL ++ +E A G ++ LHL NQL S+ G F L
Sbjct: 556 EATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFRGLDGL 615
Query: 149 ASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGN---- 204
+L L NNR+S + + F GL ++ L+L N + + AF L SL L L N
Sbjct: 616 RTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLANPFNC 675
Query: 205 --RLAYL-----QPALFSGLAE------LRELDLSRNALRAIKANVFVQ----LPRLQ-- 245
+LA+L + + +G LR++ L A + + LPR Q
Sbjct: 676 NCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGGCLPRPQCP 735
Query: 246 -----------------------------KLYLDRNLIAAVAPGAFLGLKALRWLDLSHN 276
+LYLD N V PG K L+ +DLS+N
Sbjct: 736 QECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLV-PGQLSTFKYLQLVDLSNN 794
Query: 277 RVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEG 336
+++ L +F + L L LS+NA+ + P F+ L L L L N I L E F
Sbjct: 795 KISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFAD 854
Query: 337 LGQLEVLTLDHNQL 350
+ L L + N L
Sbjct: 855 VTSLSHLAIGANPL 868
Score = 74.7 bits (182), Expect = 2e-13
Identities = 52/154 (33%), Positives = 74/154 (48%)
Query: 317 EELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRN 376
E L+L N I ++ + F GL QL VL L NQ+ V+ GAF + + + L+ N L
Sbjct: 64 ERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQLHM 123
Query: 377 LPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAEL 436
LPE +F+ L L L + + I F G + L+ L L N + IEE + L L
Sbjct: 124 LPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALRGL 183
Query: 437 LELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRL 470
L L +N +T +P F + KL L N L
Sbjct: 184 EVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Score = 69.7 bits (169), Expect = 7e-12
Identities = 49/160 (30%), Positives = 72/160 (45%), Gaps = 9/160 (5%)
Query: 23 RSLEGADPGTPGEAEGPACPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLD 82
R EG + G G P CP C C + V CS+++L LP G+P L+LD
Sbjct: 718 RCEEGQEEG--GCLPRPQCPQECACL------DTVVRCSNKHLRALPKGIPKNVTELYLD 769
Query: 83 GNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTF 142
GN + V P L ++L ++ SL + + L L L N L+ + F
Sbjct: 770 GNQFTLV-PGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAF 828
Query: 143 AHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSL 182
+L L L N +S L++G+F + SL L +G N L
Sbjct: 829 QGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
Score = 60.8 bits (146), Expect = 3e-09
Identities = 42/156 (26%), Positives = 73/156 (46%)
Query: 363 NVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGL 422
N + L+GN + + + F GL +L L L + +G + F + L RL L N L
Sbjct: 62 NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Query: 423 VGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQ 482
+ E L LDL+ N + +P + F+G L+ L L +N+++ + A L+
Sbjct: 122 HMLPELLFQNNQALSRLDLSENAIQAIPRKAFRGATDLKNLQLDKNQISCIEEGAFRALR 181
Query: 483 RAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
L +++N + +P S + +LR L +N L
Sbjct: 182 GLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNHL 217
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.140 0.428
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,771,978
Number of Sequences: 37866
Number of extensions: 1188037
Number of successful extensions: 8294
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 203
Number of HSP's successfully gapped in prelim test: 94
Number of HSP's that attempted gapping in prelim test: 2875
Number of HSP's gapped (non-prelim): 2063
length of query: 605
length of database: 18,247,518
effective HSP length: 108
effective length of query: 497
effective length of database: 14,157,990
effective search space: 7036521030
effective search space used: 7036521030
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.