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Search of human proteins with 4758460
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4758460 glycoprotein V (platelet) [Homo sapiens]
(560 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 1120 0.0
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 259 6e-69
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 259 6e-69
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 207 2e-53
gi|225579152 insulin-like growth factor binding protein, acid la... 161 2e-39
gi|4826772 insulin-like growth factor binding protein, acid labi... 161 2e-39
gi|188528675 slit homolog 1 [Homo sapiens] 140 2e-33
gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo... 140 2e-33
gi|40255157 leucine-rich repeats and immunoglobulin-like domains... 140 3e-33
gi|62912470 leucine-rich repeat-containing G protein-coupled rec... 138 2e-32
gi|76880480 hypothetical protein LOC9865 [Homo sapiens] 137 3e-32
gi|62912472 leucine-rich repeat-containing G protein-coupled rec... 133 4e-31
gi|4504379 leucine-rich repeat-containing G protein-coupled rece... 132 6e-31
gi|157694513 leucine-rich repeat-containing G protein-coupled re... 132 8e-31
gi|54607118 leucine-rich repeats and immunoglobulin-like domains... 130 2e-30
gi|12007646 nyctalopin precursor [Homo sapiens] 128 1e-29
gi|51317373 netrin-G1 ligand [Homo sapiens] 128 2e-29
gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens] 127 2e-29
gi|88702793 slit-like 2 [Homo sapiens] 125 1e-28
gi|209862903 leucine-rich repeats and immunoglobulin-like domain... 124 3e-28
gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens] 120 3e-27
gi|122937309 leucine rich repeat containing 4B [Homo sapiens] 119 6e-27
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 115 8e-26
gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo... 115 1e-25
gi|15029530 leucine rich repeat containing 4 [Homo sapiens] 115 1e-25
gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens] 115 1e-25
gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens] 115 1e-25
gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens] 115 1e-25
gi|157426829 leucine rich repeat and Ig domain containing 3 [Hom... 114 2e-25
gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens] 114 2e-25
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 1120 bits (2896), Expect = 0.0
Identities = 560/560 (100%), Positives = 560/560 (100%)
Query: 1 MLRGTLLCAVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGM 60
MLRGTLLCAVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGM
Sbjct: 1 MLRGTLLCAVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGM 60
Query: 61 GRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDK 120
GRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDK
Sbjct: 61 GRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDK 120
Query: 121 MVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGN 180
MVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGN
Sbjct: 121 MVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGN 180
Query: 181 NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDR 240
NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDR
Sbjct: 181 NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDR 240
Query: 241 LPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRT 300
LPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRT
Sbjct: 241 LPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRT 300
Query: 301 QLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLR 360
QLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLR
Sbjct: 301 QLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLR 360
Query: 361 GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH 420
GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH
Sbjct: 361 GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH 420
Query: 421 NSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGPPP 480
NSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGPPP
Sbjct: 421 NSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGPPP 480
Query: 481 RPAADSSSEAPVHPALAPNSSEPWVWAQPVTTGKGQDHSPFWGFYFLLLAVQAMITVIIV 540
RPAADSSSEAPVHPALAPNSSEPWVWAQPVTTGKGQDHSPFWGFYFLLLAVQAMITVIIV
Sbjct: 481 RPAADSSSEAPVHPALAPNSSEPWVWAQPVTTGKGQDHSPFWGFYFLLLAVQAMITVIIV 540
Query: 541 FAMIKIGQLFRKLIRERALG 560
FAMIKIGQLFRKLIRERALG
Sbjct: 541 FAMIKIGQLFRKLIRERALG 560
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 259 bits (661), Expect = 6e-69
Identities = 176/531 (33%), Positives = 255/531 (48%), Gaps = 12/531 (2%)
Query: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLM 80
CP C C +C+G + + LP N + + L F ++ L L
Sbjct: 31 CPSECTCSRASQVECTGARIVAVPT-PLPWNAMSLQILNTHITELNESPFLNISALIALR 89
Query: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
I + +S + PG F +L L+ L L+ NK+ LP L + LE L L N L I
Sbjct: 90 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 149
Query: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
F + NL+EL L+ N L+++P F +L L L+L N+LTH+ + L+ L
Sbjct: 150 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 209
Query: 201 LHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
L+ NRL + G + L L EL +N I ++PG F NL L LS NH++ LP +
Sbjct: 210 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 269
Query: 261 LFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLG 320
+F+ L LTLF N L EL +FG M L+ELWL + +LP F NL +L+ L
Sbjct: 270 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL- 328
Query: 321 VTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPR 380
+ ++S + GAF GL EL+ L+LH+N L L + R L L+ +SL+ NRLR LP
Sbjct: 329 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 388
Query: 381 ALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHL 440
+F N++ L ++QL +NQLE LP +F L +L E+ L N WRCD + P WL +
Sbjct: 389 NIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 448
Query: 441 GLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGP--PPRPAADSSSEAPVHPALAP 498
+G + P C P G L + + P P P P + P +P
Sbjct: 449 PRLGTDTVPVCFSPANVRGQSL-IIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTS 507
Query: 499 NSS-----EPWVWAQPVTTGKGQDHSPFWGFYFLL--LAVQAMITVIIVFA 542
SS P +TT + D WG LA+ A++ I+ A
Sbjct: 508 VSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALA 558
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 259 bits (661), Expect = 6e-69
Identities = 176/531 (33%), Positives = 255/531 (48%), Gaps = 12/531 (2%)
Query: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLM 80
CP C C +C+G + + LP N + + L F ++ L L
Sbjct: 25 CPSECTCSRASQVECTGARIVAVPT-PLPWNAMSLQILNTHITELNESPFLNISALIALR 83
Query: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
I + +S + PG F +L L+ L L+ NK+ LP L + LE L L N L I
Sbjct: 84 IEKNELSRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPA 143
Query: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
F + NL+EL L+ N L+++P F +L L L+L N+LTH+ + L+ L
Sbjct: 144 HFSQCSNLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLR 203
Query: 201 LHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
L+ NRL + G + L L EL +N I ++PG F NL L LS NH++ LP +
Sbjct: 204 LYENRLTDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPS 263
Query: 261 LFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLG 320
+F+ L LTLF N L EL +FG M L+ELWL + +LP F NL +L+ L
Sbjct: 264 IFMQLPQLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVL- 322
Query: 321 VTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPR 380
+ ++S + GAF GL EL+ L+LH+N L L + R L L+ +SL+ NRLR LP
Sbjct: 323 ILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPG 382
Query: 381 ALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHL 440
+F N++ L ++QL +NQLE LP +F L +L E+ L N WRCD + P WL +
Sbjct: 383 NIFANVNGLMAIQLQNNQLENLPLGIFDHLGKLCELRLYDNPWRCDSDILPLRNWLLLNQ 442
Query: 441 GLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPRGP--PPRPAADSSSEAPVHPALAP 498
+G + P C P G L + + P P P P + P +P
Sbjct: 443 PRLGTDTVPVCFSPANVRGQSL-IIINVNVAVPSVHVPEVPSYPETPWYPDTPSYPDTTS 501
Query: 499 NSS-----EPWVWAQPVTTGKGQDHSPFWGFYFLL--LAVQAMITVIIVFA 542
SS P +TT + D WG LA+ A++ I+ A
Sbjct: 502 VSSTTELTSPVEDYTDLTTIQVTDDRSVWGMTQAQSGLAIAAIVIGIVALA 552
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 207 bits (528), Expect = 2e-53
Identities = 155/477 (32%), Positives = 220/477 (46%), Gaps = 29/477 (6%)
Query: 1 MLRGTLLCAVLGLLRAQPF-PCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFG 59
ML G L LL A+P PCP C C ++ CS ++A + L +P +I+
Sbjct: 1 MLPGAWLLWTSLLLLARPAQPCPMGCDCFVQEVF-CSDEELATVP-LDIPPYTKNIIFVE 58
Query: 60 MGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLD 119
L++++F L +++ ++ + P F L +L+ L ++ + +L +
Sbjct: 59 TSFTTLETRAFGSNPNLTKVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFS 118
Query: 120 KMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSG 179
+ L +L L+ N L + + +FQ L L+ L L NQL LP LF L +LK L+L+
Sbjct: 119 NLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQ 178
Query: 180 NNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFD 239
N L LP+ L L+ L L +N L L G+ LG+L EL N+I + P F
Sbjct: 179 NLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFS 238
Query: 240 RLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR 299
+L L L L RN + LP ++F NLT L+L N L LP LF L L L
Sbjct: 239 QLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWNMLRVLPAGLFAHTPCLVGLSLTH 298
Query: 300 TQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLL 359
QL T+ F +LS LR L L N +T LP G+
Sbjct: 299 NQLETVAEGTFAHLSNLRSL-------------------------MLSYNAITHLPAGIF 333
Query: 360 RGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLG 419
R L +L ++ L N L AL ALF+NLS LE + L NQL TLP +F L + L
Sbjct: 334 RDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALH 393
Query: 420 HNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPR 476
N W+CDC L WL+Q+ + + CAGP G + AL CP R
Sbjct: 394 GNPWQCDCHLAYLFNWLQQYTDRLLNIQ-TYCAGPAYLKGQVVPALNEKQLVCPVTR 449
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 161 bits (407), Expect = 2e-39
Identities = 122/360 (33%), Positives = 172/360 (47%), Gaps = 1/360 (0%)
Query: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
L+ F G+ L L + + ++ + F L L+ L L+ N++ +L AL + L
Sbjct: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
Query: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
+L L NALR I N+F +L LQ+L L++N + + F L+ L+ LDLS N +
Sbjct: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
Query: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244
L + L L L N + SL L L ELQ N IR +A +F+ L L
Sbjct: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
Query: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRT 304
LTL N L + + FL N+ ++ L N L LP +F +G L L L + L
Sbjct: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 438
Query: 305 LPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGK 364
+ F LS LR L + L + + + GL EL L L SN LT LP L +GLGK
Sbjct: 439 IRPHTFTGLSGLRRLFLK-DNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 497
Query: 365 LRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
L + L RNRL LP L + + HN+LE LP + L RL + L +NS R
Sbjct: 498 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 557
Score = 155 bits (391), Expect = 1e-37
Identities = 133/453 (29%), Positives = 200/453 (44%), Gaps = 53/453 (11%)
Query: 21 CPPACKCVFRDAAQ-----CSGGDVARI--------SALGLPTN---------------L 52
CP AC C + D A CS ++ R+ AL L N L
Sbjct: 79 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 138
Query: 53 THILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITH 112
+ L G G L+ Q+ G+ L L + + + ++A GTF+ L +L LS N+++
Sbjct: 139 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 198
Query: 113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENL 172
L L + + L L L N+L + F+ L +L+EL L N+L +L +LF+ L L
Sbjct: 199 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 258
Query: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
+ LDLS N L + + +L++L L N + ++ G L AL L N +
Sbjct: 259 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 318
Query: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292
+ F L L L LS N +A L F H L L L N + +L F +G L
Sbjct: 319 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 378
Query: 293 QELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALH----- 347
+ L L+ QL+ + A AF L+ + + ++ L LP+ F+GLG+L L L
Sbjct: 379 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLS-GNCLRNLPEQVFRGLGKLHSLHLEGSCLG 437
Query: 348 -------------------SNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSS 388
NGL + + L GL +L ++ L N+L LP LF+ L
Sbjct: 438 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 497
Query: 389 LESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
LE + L N+L LP D G L R + + HN
Sbjct: 498 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHN 530
Score = 116 bits (291), Expect = 5e-26
Identities = 84/264 (31%), Positives = 123/264 (46%)
Query: 69 SFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLF 128
+F G+ L+ L +S + ++ + TF L+ L+ LRLS N I L + LE+L
Sbjct: 299 AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQ 358
Query: 129 LDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKG 188
L HN +R + + F+ L L+ L L+ NQL + A F L N+ +++LSGN L +LP+
Sbjct: 359 LGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQ 418
Query: 189 LLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLT 248
+ KL L L + L + L L L N + I + L L L
Sbjct: 419 VFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELD 478
Query: 249 LSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAA 308
L+ N L LP LF L L L N LAELP G + L ++ +L LP +
Sbjct: 479 LTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNS 538
Query: 309 AFRNLSRLRYLGVTLSPRLSALPQ 332
L RLRYL + + + PQ
Sbjct: 539 LLAPLGRLRYLSLRNNSLRTFTPQ 562
Score = 79.3 bits (194), Expect = 8e-15
Identities = 58/161 (36%), Positives = 76/161 (47%), Gaps = 23/161 (14%)
Query: 287 GEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGV------TLSPR-------------- 326
G GG Q LWL+ L ++P AAF+NLS L +L + +L P+
Sbjct: 109 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 168
Query: 327 ---LSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALF 383
L +L G F L L L +N L+ L DGL GLG L ++L N L LP A F
Sbjct: 169 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 228
Query: 384 RNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
R L SL + L N+L L +F L L E+ L N+ R
Sbjct: 229 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALR 269
Score = 66.6 bits (161), Expect = 6e-11
Identities = 54/161 (33%), Positives = 76/161 (47%), Gaps = 1/161 (0%)
Query: 46 LGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRL 105
LGL TN+ + L G L Q F G+ L L + S + + P TF+ L L+ L L
Sbjct: 397 LGL-TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFL 455
Query: 106 SRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASL 165
N + + L + L +L L N L + +FQ L L+ L L++N+L LPA
Sbjct: 456 KDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADA 515
Query: 166 FTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
L+ LD+S N L LP LL +L L L +N L
Sbjct: 516 LGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 556
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 161 bits (407), Expect = 2e-39
Identities = 122/360 (33%), Positives = 172/360 (47%), Gaps = 1/360 (0%)
Query: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
L+ F G+ L L + + ++ + F L L+ L L+ N++ +L AL + L
Sbjct: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
Query: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
+L L NALR I N+F +L LQ+L L++N + + F L+ L+ LDLS N +
Sbjct: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
Query: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244
L + L L L N + SL L L ELQ N IR +A +F+ L L
Sbjct: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
Query: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRT 304
LTL N L + + FL N+ ++ L N L LP +F +G L L L + L
Sbjct: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGR 400
Query: 305 LPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGK 364
+ F LS LR L + L + + + GL EL L L SN LT LP L +GLGK
Sbjct: 401 IRPHTFTGLSGLRRLFLK-DNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 459
Query: 365 LRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
L + L RNRL LP L + + HN+LE LP + L RL + L +NS R
Sbjct: 460 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLR 519
Score = 155 bits (391), Expect = 1e-37
Identities = 133/453 (29%), Positives = 200/453 (44%), Gaps = 53/453 (11%)
Query: 21 CPPACKCVFRDAAQ-----CSGGDVARI--------SALGLPTN---------------L 52
CP AC C + D A CS ++ R+ AL L N L
Sbjct: 41 CPAACVCSYDDDADELSVFCSSRNLTRLPDGVPGGTQALWLDGNNLSSVPPAAFQNLSSL 100
Query: 53 THILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITH 112
+ L G G L+ Q+ G+ L L + + + ++A GTF+ L +L LS N+++
Sbjct: 101 GFLNLQGGQLGSLEPQALLGLENLCHLHLERNQLRSLALGTFAHTPALASLGLSNNRLSR 160
Query: 113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENL 172
L L + + L L L N+L + F+ L +L+EL L N+L +L +LF+ L L
Sbjct: 161 LEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGLGSLRELVLAGNRLAYLQPALFSGLAEL 220
Query: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
+ LDLS N L + + +L++L L N + ++ G L AL L N +
Sbjct: 221 RELDLSRNALRAIKANVFVQLPRLQKLYLDRNLIAAVAPGAFLGLKALRWLDLSHNRVAG 280
Query: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292
+ F L L L LS N +A L F H L L L N + +L F +G L
Sbjct: 281 LLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQLGHNRIRQLAERSFEGLGQL 340
Query: 293 QELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALH----- 347
+ L L+ QL+ + A AF L+ + + ++ L LP+ F+GLG+L L L
Sbjct: 341 EVLTLDHNQLQEVKAGAFLGLTNVAVMNLS-GNCLRNLPEQVFRGLGKLHSLHLEGSCLG 399
Query: 348 -------------------SNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSS 388
NGL + + L GL +L ++ L N+L LP LF+ L
Sbjct: 400 RIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGK 459
Query: 389 LESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
LE + L N+L LP D G L R + + HN
Sbjct: 460 LEYLLLSRNRLAELPADALGPLQRAFWLDVSHN 492
Score = 116 bits (291), Expect = 5e-26
Identities = 84/264 (31%), Positives = 123/264 (46%)
Query: 69 SFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLF 128
+F G+ L+ L +S + ++ + TF L+ L+ LRLS N I L + LE+L
Sbjct: 261 AFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDLHFLEELQ 320
Query: 129 LDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKG 188
L HN +R + + F+ L L+ L L+ NQL + A F L N+ +++LSGN L +LP+
Sbjct: 321 LGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNCLRNLPEQ 380
Query: 189 LLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLT 248
+ KL L L + L + L L L N + I + L L L
Sbjct: 381 VFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSLWGLAELLELD 440
Query: 249 LSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAA 308
L+ N L LP LF L L L N LAELP G + L ++ +L LP +
Sbjct: 441 LTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVSHNRLEALPNS 500
Query: 309 AFRNLSRLRYLGVTLSPRLSALPQ 332
L RLRYL + + + PQ
Sbjct: 501 LLAPLGRLRYLSLRNNSLRTFTPQ 524
Score = 79.3 bits (194), Expect = 8e-15
Identities = 58/161 (36%), Positives = 76/161 (47%), Gaps = 23/161 (14%)
Query: 287 GEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGV------TLSPR-------------- 326
G GG Q LWL+ L ++P AAF+NLS L +L + +L P+
Sbjct: 71 GVPGGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLE 130
Query: 327 ---LSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALF 383
L +L G F L L L +N L+ L DGL GLG L ++L N L LP A F
Sbjct: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 190
Query: 384 RNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
R L SL + L N+L L +F L L E+ L N+ R
Sbjct: 191 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALR 231
Score = 66.6 bits (161), Expect = 6e-11
Identities = 54/161 (33%), Positives = 76/161 (47%), Gaps = 1/161 (0%)
Query: 46 LGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRL 105
LGL TN+ + L G L Q F G+ L L + S + + P TF+ L L+ L L
Sbjct: 359 LGL-TNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFL 417
Query: 106 SRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASL 165
N + + L + L +L L N L + +FQ L L+ L L++N+L LPA
Sbjct: 418 KDNGLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADA 477
Query: 166 FTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
L+ LD+S N L LP LL +L L L +N L
Sbjct: 478 LGPLQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSL 518
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 140 bits (354), Expect = 2e-33
Identities = 118/455 (25%), Positives = 197/455 (43%), Gaps = 40/455 (8%)
Query: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLM 80
CP C C C G + I +P N + L G + F+G+ L+ L
Sbjct: 34 CPALCTCT-GTTVDCHGTGLQAIPK-NIPRNTERLELNGNNITRIHKNDFAGLKQLRVLQ 91
Query: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
+ ++ I AV G F D+ +L+ LRL+RN++ LP L L +L L NA++ I +
Sbjct: 92 LMENQIGAVERGAFDDMKELERLRLNRNQLHMLPELLFQNNQALSRLDLSENAIQAIPRK 151
Query: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
F+ +L+ L L++NQ+ + F L L++L L+ NN+T +P KL
Sbjct: 152 AFRGATDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFR 211
Query: 201 LHSNRLVS------LDSGLLN--------------SLGALTELQFHRNHIRSIAPGAFDR 240
LHSN L L L SL L + ++ G R
Sbjct: 212 LHSNHLFCDCHLAWLSQWLRQRPTIGLFTQCSGPASLRGLNVAEVQKSEFSCSGQGEAGR 271
Query: 241 LPNLSSLTLSRNHLAFLPSALF-LHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR 299
+P + + S + + + LT + A LP + E+ L
Sbjct: 272 VPTCTLSSGSCPAMCTCSNGIVDCRGKGLTAIP------ANLPET-------MTEIRLEL 318
Query: 300 TQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLL 359
++++P AF +LR + ++ + +++ + AFQGL L L L+ N +T LP G+
Sbjct: 319 NGIKSIPPGAFSPYRKLRRIDLS-NNQIAEIAPDAFQGLRSLNSLVLYGNKITDLPRGVF 377
Query: 360 RGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLG 419
GL L+ + L N++ + F++L +L + L N++++L F +L + + L
Sbjct: 378 GGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLHLA 437
Query: 420 HNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGP 454
N + CDC L +LR + G RCA P
Sbjct: 438 QNPFICDCNLKWLADFLRTNPIETSG---ARCASP 469
Score = 124 bits (312), Expect = 2e-28
Identities = 131/485 (27%), Positives = 201/485 (41%), Gaps = 57/485 (11%)
Query: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLM 80
CP C C C G + I A LP +T I L G + +FS L+R+
Sbjct: 282 CPAMCTCS-NGIVDCRGKGLTAIPA-NLPETMTEIRLELNGIKSIPPGAFSPYRKLRRID 339
Query: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
+S++ I+ +AP F L L +L L NKIT LP RG+
Sbjct: 340 LSNNQIAEIAPDAFQGLRSLNSLVLYGNKITDLP--------------------RGV--- 376
Query: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
F L LQ L LN N+++ + F +L+NL LL L N + L KG + ++ L
Sbjct: 377 -FGGLYTLQLLLLNANKINCIRPDAFQDLQNLSLLSLYDNKIQSLAKGTFTSLRAIQTLH 435
Query: 201 LHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPG--AFDRLPNLSS--LTLSRNHLAF 256
L N + D L L + R +P A R+ + S S F
Sbjct: 436 LAQNPFIC-DCNLKWLADFLRTNPIETSGARCASPRRLANKRIGQIKSKKFRCSAKEQYF 494
Query: 257 LPSA--LFLHSH-------------NLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQ 301
+P L+S ++ L ++P + EL LN +
Sbjct: 495 IPGTEDYQLNSECNSDVVCPHKCRCEANVVECSSLKLTKIPERI---PQSTAELRLNNNE 551
Query: 302 LRTLPAAA-FRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLR 360
+ L A F+ L+ L+ + ++ + ++S + GAF+G + L L +N L ++ G+ R
Sbjct: 552 ISILEATGMFKKLTHLKKINLS-NNKVSEIEDGAFEGAASVSELHLTANQLESIRSGMFR 610
Query: 361 GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH 420
GL LR + LR NR+ + F L ++ + L NQ+ T+ F L L+ + L
Sbjct: 611 GLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSLSTLNLLA 670
Query: 421 NSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGPR---G 477
N + C+C L GWLR+ + G PRC P +PL + D C + G
Sbjct: 671 NPFNCNCQLAWLGGWLRKRKIVTGN---PRCQNPDFLRQIPLQDVAFPDFRCEEGQEEGG 727
Query: 478 PPPRP 482
PRP
Sbjct: 728 CLPRP 732
Score = 105 bits (262), Expect = 1e-22
Identities = 100/379 (26%), Positives = 155/379 (40%), Gaps = 58/379 (15%)
Query: 150 ELALNQNQLDFLPAS-LFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVS 208
EL LN N++ L A+ +F L +LK ++LS N ++ + G A + L L +N+L S
Sbjct: 544 ELRLNNNEISILEATGMFKKLTHLKKINLSNNKVSEIEDGAFEGAASVSELHLTANQLES 603
Query: 209 LDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNL 268
+ SG+ L L L N I I +F L N+ L+L N + + F +L
Sbjct: 604 IRSGMFRGLDGLRTLMLRNNRISCIHNDSFTGLRNVRLLSLYDNQITTVSPGAFDTLQSL 663
Query: 269 TLLTLFENP------LAELPG------VLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRL 316
+ L L NP LA L G ++ G +L + L+ + FR
Sbjct: 664 STLNLLANPFNCNCQLAWLGGWLRKRKIVTGNPRCQNPDFLRQIPLQDVAFPDFRCEEGQ 723
Query: 317 RYLGVTLSPR------------------LSALPQGAFQGLGEL----------------- 341
G P+ L ALP+G + + EL
Sbjct: 724 EEGGCLPRPQCPQECACLDTVVRCSNKHLRALPKGIPKNVTELYLDGNQFTLVPGQLSTF 783
Query: 342 ---QVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQ 398
Q++ L +N +++L + + +L + L N L+ +P F+ L SL + L N
Sbjct: 784 KYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPLAFQGLRSLRLLSLHGND 843
Query: 399 LETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEP--PRCAGPGA 456
+ TL +F + L+ + +G N CDC L W++ G +EP RCAGP
Sbjct: 844 ISTLQEGIFADVTSLSHLAIGANPLYCDCHLRWLSSWVK-----TGYKEPGIARCAGPQD 898
Query: 457 HAGLPLWALPGGDAECPGP 475
G L P EC GP
Sbjct: 899 MEGKLLLTTPAKKFECQGP 917
Score = 85.9 bits (211), Expect = 9e-17
Identities = 65/234 (27%), Positives = 97/234 (41%), Gaps = 32/234 (13%)
Query: 243 NLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQL 302
N L L+ N++ + F L +L L EN + + F +M L+ L LNR QL
Sbjct: 62 NTERLELNGNNITRIHKNDFAGLKQLRVLQLMENQIGAVERGAFDDMKELERLRLNRNQL 121
Query: 303 RTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGL 362
LP F+N L L L N + A+P RG
Sbjct: 122 HMLPELLFQNNQALSRLD-------------------------LSENAIQAIPRKAFRGA 156
Query: 363 GKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422
L+ + L +N++ + FR L LE + L++N + T+P F +P+L L N
Sbjct: 157 TDLKNLQLDKNQISCIEEGAFRALRGLEVLTLNNNNITTIPVSSFNHMPKLRTFRLHSNH 216
Query: 423 WRCDCGLGPFLGWLRQH--LGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPG 474
CDC L WLRQ +GL +C+GP + GL + + + C G
Sbjct: 217 LFCDCHLAWLSQWLRQRPTIGLF-----TQCSGPASLRGLNVAEVQKSEFSCSG 265
Score = 53.1 bits (126), Expect = 6e-07
Identities = 44/162 (27%), Positives = 68/162 (41%), Gaps = 27/162 (16%)
Query: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLM 80
CP C C+ +CS + R G+P N+T + L
Sbjct: 734 CPQECACL-DTVVRCSNKHL-RALPKGIPKNVTELYL----------------------- 768
Query: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
D + + PG S L+ + LS NKI+ L + M L L L +NAL+ I
Sbjct: 769 --DGNQFTLVPGQLSTFKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNALQCIPPL 826
Query: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNL 182
FQ L +L+ L+L+ N + L +F ++ +L L + N L
Sbjct: 827 AFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
Score = 50.4 bits (119), Expect = 4e-06
Identities = 34/108 (31%), Positives = 52/108 (48%), Gaps = 1/108 (0%)
Query: 147 NLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
N+ EL L+ NQ +P L T + L+L+DLS N ++ L ++L L+L N L
Sbjct: 762 NVTELYLDGNQFTLVPGQLST-FKYLQLVDLSNNKISSLSNSSFTNMSQLTTLILSYNAL 820
Query: 207 VSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHL 254
+ L +L L H N I ++ G F + +LS L + N L
Sbjct: 821 QCIPPLAFQGLRSLRLLSLHGNDISTLQEGIFADVTSLSHLAIGANPL 868
>gi|52138725 leucine rich repeat and Ig domain containing 4 [Homo
sapiens]
Length = 593
Score = 140 bits (354), Expect = 2e-33
Identities = 112/331 (33%), Positives = 161/331 (48%), Gaps = 6/331 (1%)
Query: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
E L L N L G+ Q M +L LQEL L+ NQL L F L++L L L GN L
Sbjct: 63 ELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRI 122
Query: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244
+ G+ + L L L N++V G LG+L +L+ NH+ +APGAF L L
Sbjct: 123 MGPGVFSGLSALTLLDLRLNQIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAGLAKL 182
Query: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR-TQLR 303
S+LTL R +L+ +P L L L E + LP +G L+EL ++ L
Sbjct: 183 STLTLERCNLSTVPGLALARLPALVALRLRELDIGRLPAGALRGLGQLKELEIHLWPSLE 242
Query: 304 TLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLG 363
L + L+ L L +T LS++P A L L+VL L N ++A+P L L
Sbjct: 243 ALDPGSLVGLN-LSSLAITRC-NLSSVPFQALYHLSFLRVLDLSQNPISAIPARRLSPLV 300
Query: 364 KLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSW 423
+L+++ L L ++ F L++ + + N L+TL F + +L + L N
Sbjct: 301 RLQELRLSGACLTSIAAHAFHGLTAFHLLDVADNALQTLEETAFPSPDKLVTLRLSGNPL 360
Query: 424 RCDCGLGPFLGWLRQHLGLVGGEEPPRCAGP 454
CDC L +L LR+HL G PP CAGP
Sbjct: 361 TCDCRL-LWLLRLRRHLDF--GMSPPACAGP 388
Score = 120 bits (302), Expect = 3e-27
Identities = 102/333 (30%), Positives = 149/333 (44%), Gaps = 3/333 (0%)
Query: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLM 80
CP C C + A G GLP + + L G LQ S +++LQ L
Sbjct: 31 CPAVCDCTSQPQAVLCGHRQLEAVPGGLPLDTELLDLSGNRLWGLQQGMLSRLSLLQELD 90
Query: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
+S + +S + PG F L L TLRL N++ + + + L L L N +
Sbjct: 91 LSYNQLSTLEPGAFHGLQSLLTLRLQGNRLRIMGPGVFSGLSALTLLDLRLNQIVLFLDG 150
Query: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
F +L +LQ+L + N L F+ F L L L L NL+ +P L L L
Sbjct: 151 AFGELGSLQKLEVGDNHLVFVAPGAFAGLAKLSTLTLERCNLSTVPGLALARLPALVALR 210
Query: 201 LHSNRLVSLDSGLLNSLGALTELQFHR-NHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPS 259
L + L +G L LG L EL+ H + ++ PG+ L NLSSL ++R +L+ +P
Sbjct: 211 LRELDIGRLPAGALRGLGQLKELEIHLWPSLEALDPGSLVGL-NLSSLAITRCNLSSVPF 269
Query: 260 ALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYL 319
H L +L L +NP++ +P + LQEL L+ L ++ A AF L+ L
Sbjct: 270 QALYHLSFLRVLDLSQNPISAIPARRLSPLVRLQELRLSGACLTSIAAHAFHGLTAFHLL 329
Query: 320 GVTLSPRLSALPQGAFQGLGELQVLALHSNGLT 352
V L L + AF +L L L N LT
Sbjct: 330 DVA-DNALQTLEETAFPSPDKLVTLRLSGNPLT 361
Score = 42.7 bits (99), Expect = 9e-04
Identities = 38/121 (31%), Positives = 54/121 (44%), Gaps = 2/121 (1%)
Query: 340 ELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQL 399
+ ++L L N L L G+L L L+++ L N+L L F L SL +++L N+L
Sbjct: 61 DTELLDLSGNRLWGLQQGMLSRLSLLQELDLSYNQLSTLEPGAFHGLQSLLTLRLQGNRL 120
Query: 400 ETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAG 459
+ VF L LT + L N + L G L L G+ PGA AG
Sbjct: 121 RIMGPGVFSGLSALTLLDLRLN--QIVLFLDGAFGELGSLQKLEVGDNHLVFVAPGAFAG 178
Query: 460 L 460
L
Sbjct: 179 L 179
>gi|40255157 leucine-rich repeats and immunoglobulin-like domains 3
isoform 2 [Homo sapiens]
Length = 1119
Score = 140 bits (353), Expect = 3e-33
Identities = 127/456 (27%), Positives = 212/456 (46%), Gaps = 27/456 (5%)
Query: 4 GTLLCAVLGLLR----------------AQPFPCPPACKCVFRDAAQCSGGDVARISALG 47
G LLCAVLG A PCP C+C+ D CS +AR+
Sbjct: 14 GLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCL-GDLLDCSRKRLARLPE-P 71
Query: 48 LPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSR 107
LP+ + + L +++ S S + L+ + ++++ + + P + L L+
Sbjct: 72 LPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAG 130
Query: 108 NKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFT 167
N+I + L + LE L L N + + Q F L L+ L LN N++ + F
Sbjct: 131 NRIVEILPEHLKEFQSLETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFD 188
Query: 168 NLEN-LKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFH 226
NL N L +L L+ N ++ +P + +L+ L L+ N++ ++D LGAL L+
Sbjct: 189 NLANTLLVLKLNRNRISAIPPKMFKLP-QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQ 247
Query: 227 RNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLF 286
RN + + GAF L N+ L L N+L + L L L +N + + +
Sbjct: 248 RNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAW 307
Query: 287 GEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLAL 346
L EL L L L ++F LS L L + + R+S + AF+GL L+ L L
Sbjct: 308 EFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIG-NNRVSYIADCAFRGLSSLKTLDL 366
Query: 347 HSNGLT-ALPD--GLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLP 403
+N ++ + D G GL KLR++ L+ NR+R++ + F L +LE + L N + +L
Sbjct: 367 KNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQ 426
Query: 404 GDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQH 439
G+ F + +L ++ L +S CDC L W+ ++
Sbjct: 427 GNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAEN 462
>gi|62912470 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 1 [Homo sapiens]
Length = 967
Score = 138 bits (347), Expect = 2e-32
Identities = 116/430 (26%), Positives = 186/430 (43%), Gaps = 32/430 (7%)
Query: 2 LRGTLLCAVLGLLRA-----QPFPCPPACK--CVFRDAAQCSGGDVARISALGLPTNLTH 54
LR LCA L R QP P P AC C ++ D + + +P +L
Sbjct: 7 LRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDP 66
Query: 55 ILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLP 114
+ + L +S ++++ + PG F L L+ LRLS N ++H+P
Sbjct: 67 LTAY--------------------LDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIP 106
Query: 115 GALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKL 174
G + L+ L L +N L GI +L +LQ L L+ N + +P F L +L+
Sbjct: 107 GQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRH 166
Query: 175 LDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIA 234
L L N LT +P L L+ + L NR+ + +L +L L H N I+ +
Sbjct: 167 LWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLG 226
Query: 235 PGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQE 294
+F+ L NL +L L+ N L P A+ L L N + +P F LQ
Sbjct: 227 THSFEGLHNLETLDLNYNKLQEFPVAIRTLG-RLQELGFHNNNIKAIPEKAFMGNPLLQT 285
Query: 295 LWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTAL 354
+ ++ + +AF+ L +L L + + + P +G L++L L G+ L
Sbjct: 286 IHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLL 343
Query: 355 PDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLT 414
P G+ + L +LR + L N++ LP LE + L HN++ + D F L L
Sbjct: 344 PSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQ 401
Query: 415 EVLLGHNSWR 424
+ L N+ R
Sbjct: 402 ALDLSWNAIR 411
Score = 68.2 bits (165), Expect = 2e-11
Identities = 63/236 (26%), Positives = 102/236 (43%), Gaps = 29/236 (12%)
Query: 51 NLTHILLFGMGRGVLQ---SQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSR 107
NLT +++ + +Q + SF G+ L+ L ++ + + P L +L+ L
Sbjct: 208 NLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRLQELGFHN 266
Query: 108 NKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALN------------- 154
N I +P LL+ + N ++ + ++ FQ L L L+LN
Sbjct: 267 NNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQEFPDLKG 326
Query: 155 ----------QNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSN 204
+ + LP+ + L L++L+LS N + LP L KLE + L N
Sbjct: 327 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQKLEEIGLQHN 384
Query: 205 RLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
R+ + + + L +L L N IRSI P AF L +L L L+ N L LP A
Sbjct: 385 RIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLA 440
Score = 64.7 bits (156), Expect = 2e-10
Identities = 45/144 (31%), Positives = 69/144 (47%), Gaps = 2/144 (1%)
Query: 54 HILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHL 113
H L + + G T L+ L ++ + I + G L +L+ L LS N+I L
Sbjct: 308 HTLSLNGAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 367
Query: 114 PGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLK 173
P L + LE++ L HN + I + F +L +LQ L L+ N + + F+ L +L
Sbjct: 368 PS--LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLV 425
Query: 174 LLDLSGNNLTHLPKGLLGAQAKLE 197
LDL+ N LT LP LG L+
Sbjct: 426 KLDLTDNQLTTLPLAGLGGLMHLK 449
>gi|76880480 hypothetical protein LOC9865 [Homo sapiens]
Length = 811
Score = 137 bits (345), Expect = 3e-32
Identities = 108/335 (32%), Positives = 146/335 (43%), Gaps = 23/335 (6%)
Query: 102 TLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFL 161
T L N IT++ ++ L +L L +N +R + F+KL L+EL L N L L
Sbjct: 63 TYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQAL 122
Query: 162 PASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALT 221
L L++L +GN ++ L +G L +L L N L +L + LG L
Sbjct: 123 APGTLAPLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLL 182
Query: 222 ELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAEL 281
L N IR + AF +L L L LS N L PS H T
Sbjct: 183 YLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQ--PSL----RHAAT------------ 224
Query: 282 PGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGEL 341
F + L L L+ L+ L F++L RL L + +L+ L AF GL L
Sbjct: 225 ----FAPLRSLSSLILSANNLQHLGPRIFQHLPRLGLLSLR-GNQLTHLAPEAFWGLEAL 279
Query: 342 QVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLET 401
+ L L N L+ LP LL L L + L N L AL A F +L L + L +N L
Sbjct: 280 RELRLEGNRLSQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSA 339
Query: 402 LPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWL 436
L GD+F A P L + L N W CDC L W+
Sbjct: 340 LSGDIFAASPALYRLDLDGNGWTCDCRLRGLKRWM 374
Score = 112 bits (279), Expect = 1e-24
Identities = 100/337 (29%), Positives = 143/337 (42%), Gaps = 32/337 (9%)
Query: 6 LLCAVLGLLRAQPFP---CPPACKCVFRDAAQCSGGD---VARISALGLP---------- 49
LL V G L P CP C C C+ V + S+L P
Sbjct: 9 LLLVVCGCLALPPLAEPVCPERCDCQHPQHLLCTNRGLRVVPKTSSLPSPHDVLTYSLGG 68
Query: 50 ---TNLTHILLFGMGR-----------GVLQSQSFSGMTVLQRLMISDSHISAVAPGTFS 95
TN+T +G+ L ++F ++ L+ L + ++ + A+APGT +
Sbjct: 69 NFITNITAFDFHRLGQLRRLDLQYNQIRSLHPKTFEKLSRLEELYLGNNLLQALAPGTLA 128
Query: 96 DLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQ 155
L KL+ L + N+I+ L + + L +L LD NAL + +F L NL L L
Sbjct: 129 PLRKLRILYANGNEISRLSRGSFEGLESLVKLRLDGNALGALPDAVFAPLGNLLYLHLES 188
Query: 156 NQLDFLPASLFTNLENLKLLDLSGNNLTHLPK--GLLGAQAKLERLLLHSNRLVSLDSGL 213
N++ FL + F L L+ L+LS N L + L L+L +N L L +
Sbjct: 189 NRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSANNLQHLGPRI 248
Query: 214 LNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTL 273
L L L N + +AP AF L L L L N L+ LP+AL H+L L L
Sbjct: 249 FQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEPLHSLEALDL 308
Query: 274 FENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAF 310
N L+ L FG +G L+EL L L L F
Sbjct: 309 SGNELSALHPATFGHLGRLRELSLRNNALSALSGDIF 345
Score = 68.6 bits (166), Expect = 1e-11
Identities = 67/223 (30%), Positives = 97/223 (43%), Gaps = 29/223 (13%)
Query: 247 LTLSRNHLAFLPSALFLHS-HNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTL 305
L + L +P L S H++ +L N + + F +G L+ L L Q+R+L
Sbjct: 39 LLCTNRGLRVVPKTSSLPSPHDVLTYSLGGNFITNITAFDFHRLGQLRRLDLQYNQIRSL 98
Query: 306 PAAAFRNLSRLR--YLG---------VTLSP------------RLSALPQGAFQGLGELQ 342
F LSRL YLG TL+P +S L +G+F+GL L
Sbjct: 99 HPKTFEKLSRLEELYLGNNLLQALAPGTLAPLRKLRILYANGNEISRLSRGSFEGLESLV 158
Query: 343 VLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLE-- 400
L L N L ALPD + LG L + L NR+R L + F L L + L N+L+
Sbjct: 159 KLRLDGNALGALPDAVFAPLGNLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPS 218
Query: 401 TLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLV 443
F L L+ ++L N+ + LGP + LGL+
Sbjct: 219 LRHAATFAPLRSLSSLILSANNLQ---HLGPRIFQHLPRLGLL 258
Score = 67.0 bits (162), Expect = 4e-11
Identities = 56/180 (31%), Positives = 82/180 (45%), Gaps = 2/180 (1%)
Query: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHI--SAVAPGTFSDLIKLKTLRLSRN 108
NL ++ L L +F+ + L+ L +S + + S TF+ L L +L LS N
Sbjct: 180 NLLYLHLESNRIRFLGKNAFAQLGKLRFLNLSANELQPSLRHAATFAPLRSLSSLILSAN 239
Query: 109 KITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTN 168
+ HL + + L L L N L + F L L+EL L N+L LP +L
Sbjct: 240 NLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRLSQLPTALLEP 299
Query: 169 LENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRN 228
L +L+ LDLSGN L+ L G +L L L +N L +L + + AL L N
Sbjct: 300 LHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASPALYRLDLDGN 359
Score = 60.8 bits (146), Expect = 3e-09
Identities = 43/133 (32%), Positives = 64/133 (48%)
Query: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKI 110
+L+ ++L L + F + L L + + ++ +AP F L L+ LRL N++
Sbjct: 230 SLSSLILSANNLQHLGPRIFQHLPRLGLLSLRGNQLTHLAPEAFWGLEALRELRLEGNRL 289
Query: 111 THLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLE 170
+ LP ALL+ + LE L L N L + F L L+EL+L N L L +F
Sbjct: 290 SQLPTALLEPLHSLEALDLSGNELSALHPATFGHLGRLRELSLRNNALSALSGDIFAASP 349
Query: 171 NLKLLDLSGNNLT 183
L LDL GN T
Sbjct: 350 ALYRLDLDGNGWT 362
>gi|62912472 leucine-rich repeat-containing G protein-coupled
receptor 6 isoform 2 [Homo sapiens]
Length = 915
Score = 133 bits (335), Expect = 4e-31
Identities = 98/344 (28%), Positives = 160/344 (46%), Gaps = 5/344 (1%)
Query: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
+S ++++ + PG F L L+ LRLS N ++H+PG + L+ L L +N L GI
Sbjct: 21 LSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAE 80
Query: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
+L +LQ L L+ N + +P F L +L+ L L N LT +P L L+ +
Sbjct: 81 ALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMT 140
Query: 201 LHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
L NR+ + +L +L L H N I+ + +F+ L NL +L L+ N L P A
Sbjct: 141 LALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVA 200
Query: 261 LFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLG 320
+ L L N + +P F LQ + ++ + +AF+ L +L L
Sbjct: 201 IRTLG-RLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLS 259
Query: 321 VTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPR 380
+ + + P +G L++L L G+ LP G+ + L +LR + L N++ LP
Sbjct: 260 LNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEELPS 317
Query: 381 ALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
LE + L HN++ + D F L L + L N+ R
Sbjct: 318 --LHRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIR 359
Score = 125 bits (313), Expect = 1e-28
Identities = 99/358 (27%), Positives = 165/358 (46%), Gaps = 7/358 (1%)
Query: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
LQ F + L+ L +S +H+S + FS L LK L L N++ +P L ++ L
Sbjct: 29 LQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSL 88
Query: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
+ L LD N + + + F+ L +L+ L L+ N L +P NL L+ + L+ N ++H
Sbjct: 89 QSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISH 148
Query: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244
+P L L LH+NR+ L + L L L + N ++ P A L L
Sbjct: 149 IPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEF-PVAIRTLGRL 207
Query: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLN-RTQLR 303
L N++ +P F+ + L + ++NP+ + F + L L LN ++
Sbjct: 208 QELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLNGAMDIQ 267
Query: 304 TLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLG 363
P + + L L +T + + LP G Q L L+VL L N + LP L
Sbjct: 268 EFP--DLKGTTSLEILTLTRA-GIRLLPSGMCQQLPRLRVLELSHNQIEELPS--LHRCQ 322
Query: 364 KLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
KL ++ L+ NR+ + F LSSL+++ L N + ++ + F L L ++ L N
Sbjct: 323 KLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDN 380
Score = 123 bits (308), Expect = 5e-28
Identities = 106/365 (29%), Positives = 170/365 (46%), Gaps = 11/365 (3%)
Query: 52 LTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKIT 111
L + L G + Q+FSG+ L+ LM+ ++ + + +L L++LRL N I+
Sbjct: 40 LEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQLGGIPAEALWELPSLQSLRLDANLIS 99
Query: 112 HLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLEN 171
+P + + L L+LD NAL I L LQ + L N++ +P F NL +
Sbjct: 100 LVPERSFEGLSSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTS 159
Query: 172 LKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIR 231
L +L L N + HL LE L L+ N+L + +LG L EL FH N+I+
Sbjct: 160 LVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNKLQEFPVA-IRTLGRLQELGFHNNNIK 218
Query: 232 SIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGG 291
+I AF P L ++ N + F+ + F + L L+L N ++ F ++ G
Sbjct: 219 AIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSL--NGAMDIQE--FPDLKG 274
Query: 292 ---LQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHS 348
L+ L L R +R LP+ + L RLR L ++ + ++ LP + +L+ + L
Sbjct: 275 TTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHN-QIEELP--SLHRCQKLEEIGLQH 331
Query: 349 NGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFG 408
N + + L L+ + L N +R++ F L SL + L NQL TLP G
Sbjct: 332 NRIWEIGADTFSQLSSLQALDLSWNAIRSIHPEAFSTLHSLVKLDLTDNQLTTLPLAGLG 391
Query: 409 ALPRL 413
L L
Sbjct: 392 GLMHL 396
Score = 111 bits (278), Expect = 2e-24
Identities = 91/325 (28%), Positives = 143/325 (44%), Gaps = 31/325 (9%)
Query: 122 VLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNN 181
+++ L N L + +F L L+EL L+ N L +P F+ L +LK+L L N
Sbjct: 14 IIISARDLSMNNLTELQPGLFHHLRFLEELRLSGNHLSHIPGQAFSGLYSLKILMLQNNQ 73
Query: 182 LTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRL 241
L +P L L+ L L +N + + L +L L N + I A + L
Sbjct: 74 LGGIPAEALWELPSLQSLRLDANLISLVPERSFEGLSSLRHLWLDDNALTEIPVRALNNL 133
Query: 242 PNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQ 301
P L ++TL+ N ++ +P F + +L +L L N + L F + L+ L LN +
Sbjct: 134 PALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNRIQHLGTHSFEGLHNLETLDLNYNK 193
Query: 302 LRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSN------------ 349
L+ P A R L RL+ LG + + A+P+ AF G LQ + + N
Sbjct: 194 LQEFP-VAIRTLGRLQELGFH-NNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQY 251
Query: 350 -------------GLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDH 396
+ PD L+G L ++L R +R LP + + L L ++L H
Sbjct: 252 LPKLHTLSLNGAMDIQEFPD--LKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSH 309
Query: 397 NQLETLPGDVFGALPRLTEVLLGHN 421
NQ+E LP +L E+ L HN
Sbjct: 310 NQIEELPS--LHRCQKLEEIGLQHN 332
Score = 77.0 bits (188), Expect = 4e-14
Identities = 86/332 (25%), Positives = 136/332 (40%), Gaps = 48/332 (14%)
Query: 50 TNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNK 109
++L H+ L + ++ + + LQ + ++ + IS + F +L L L L N+
Sbjct: 110 SSLRHLWLDDNALTEIPVRALNNLPALQAMTLALNRISHIPDYAFQNLTSLVVLHLHNNR 169
Query: 110 ITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNL 169
I HL + F+ L NL+ L LN N+L P ++ T L
Sbjct: 170 IQHL------------------------GTHSFEGLHNLETLDLNYNKLQEFPVAIRT-L 204
Query: 170 ENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNH 229
L+ L NN+ +P+ L+ + + N + + L L L +
Sbjct: 205 GRLQELGFHNNNIKAIPEKAFMGNPLLQTIHFYDNPIQFVGRSAFQYLPKLHTLSLN--- 261
Query: 230 IRSIAPGAFD--RLPNLSS------LTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAEL 281
GA D P+L LTL+R + LPS + L +L L N + EL
Sbjct: 262 ------GAMDIQEFPDLKGTTSLEILTLTRAGIRLLPSGMCQQLPRLRVLELSHNQIEEL 315
Query: 282 PGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGEL 341
P + L+E+ L ++ + A F LS L+ L ++ + S P+ AF L L
Sbjct: 316 PSL--HRCQKLEEIGLQHNRIWEIGADTFSQLSSLQALDLSWNAIRSIHPE-AFSTLHSL 372
Query: 342 QVLALHSNGLTALPDGLLRGLGKLRQVSLRRN 373
L L N LT LP L GLG L + L+ N
Sbjct: 373 VKLDLTDNQLTTLP---LAGLGGLMHLKLKGN 401
>gi|4504379 leucine-rich repeat-containing G protein-coupled
receptor 5 [Homo sapiens]
Length = 907
Score = 132 bits (333), Expect = 6e-31
Identities = 118/426 (27%), Positives = 189/426 (44%), Gaps = 52/426 (12%)
Query: 21 CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLM 80
CP C C D D + + LP+NL+ + L
Sbjct: 34 CPTHCHCE-PDGRMLLRVDCSDLGLSELPSNLSVFTSY--------------------LD 72
Query: 81 ISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQN 140
+S ++IS + P L L+ LRL+ N +T++P + L+ L L +N LR +
Sbjct: 73 LSMNNISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRHVPTE 132
Query: 141 MFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLL 200
Q L +LQ L L+ N + ++P S F+ L +L+ L L N LT +P + + L+ +
Sbjct: 133 ALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNALTEIPVQAFRSLSALQAMT 192
Query: 201 LHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSA 260
L N++ + +L +L L H N I S+ FD L +L +L L+ N+L P+A
Sbjct: 193 LALNKIHHIPDYAFGNLSSLVVLHLHNNRIHSLGKKCFDGLHSLETLDLNYNNLDEFPTA 252
Query: 261 ---------LFLHSHNL------------TLLTL--FENPLAELPGVLFGEMGGLQELWL 297
L HS+N+ +L+T+ ++NP+ + F + L+ L L
Sbjct: 253 IRTLSNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYDNPIQFVGRSAFQHLPELRTLTL 312
Query: 298 N-RTQLRTLP-AAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALP 355
N +Q+ P NL L G ++S+LPQ L LQVL L N L LP
Sbjct: 313 NGASQITEFPDLTGTANLESLTLTGA----QISSLPQTVCNQLPNLQVLDLSYNLLEDLP 368
Query: 356 DGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTE 415
KL+++ LR N + + F+ L SL S+ L N++ + + F LP L +
Sbjct: 369 S--FSVCQKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIK 426
Query: 416 VLLGHN 421
+ L N
Sbjct: 427 LDLSSN 432
Score = 65.1 bits (157), Expect = 2e-10
Identities = 72/263 (27%), Positives = 106/263 (40%), Gaps = 40/263 (15%)
Query: 38 GDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDL 97
G+++ + L L N H L + F G+ L+ L ++ +++ P L
Sbjct: 207 GNLSSLVVLHLHNNRIHSL---------GKKCFDGLHSLETLDLNYNNLDEF-PTAIRTL 256
Query: 98 IKLKTLRLSRNKITHLPG-ALLDKMVLLEQLFLDHNALRGIDQNMFQKL----------- 145
LK L N I +P A + L+ F D N ++ + ++ FQ L
Sbjct: 257 SNLKELGFHSNNIRSIPEKAFVGNPSLITIHFYD-NPIQFVGRSAFQHLPELRTLTLNGA 315
Query: 146 ------------VNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQ 193
NL+ L L Q+ LP ++ L NL++LDLS N L LP
Sbjct: 316 SQITEFPDLTGTANLESLTLTGAQISSLPQTVCNQLPNLQVLDLSYNLLEDLPS--FSVC 373
Query: 194 AKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNH 253
KL+++ L N + + L +L L N I I P AF LP+L L LS N
Sbjct: 374 QKLQKIDLRHNEIYEIKVDTFQQLLSLRSLNLAWNKIAIIHPNAFSTLPSLIKLDLSSNL 433
Query: 254 LAFLPSALFLHSHNLTLLTLFEN 276
L+ P H LT L L N
Sbjct: 434 LSSFP---ITGLHGLTHLKLTGN 453
Score = 57.4 bits (137), Expect = 3e-08
Identities = 35/105 (33%), Positives = 55/105 (52%), Gaps = 1/105 (0%)
Query: 318 YLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRA 377
YL ++++ +S L L L+ L L N LT +P G GL L+ + L+ N+LR
Sbjct: 70 YLDLSMN-NISQLLPNPLPSLRFLEELRLAGNALTYIPKGAFTGLYSLKVLMLQNNQLRH 128
Query: 378 LPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422
+P +NL SL+S++LD N + +P F L L + L N+
Sbjct: 129 VPTEALQNLRSLQSLRLDANHISYVPPSCFSGLHSLRHLWLDDNA 173
>gi|157694513 leucine-rich repeat-containing G protein-coupled
receptor 4 [Homo sapiens]
Length = 951
Score = 132 bits (332), Expect = 8e-31
Identities = 111/427 (25%), Positives = 188/427 (44%), Gaps = 18/427 (4%)
Query: 4 GTLLCAVLGLLR------AQPFPCPPACKCVFRDAAQCSGGDVARI-SALGLPTNLTHIL 56
G L LGLL A P C C C CSG + + L T I
Sbjct: 6 GLLCFLALGLLGSAGPSGAAPPLCAAPCSCDGDRRVDCSGKGLTAVPEGLSAFTQALDIS 65
Query: 57 LFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGA 116
+ + + L +F L+ L ++ + +S + P S L +LK L L N++ +P
Sbjct: 66 MNNITQ--LPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTVPSE 123
Query: 117 LLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLD 176
+ + L+ L LD N + + ++ F+ LV L+ L L+ N L +P +NL L+ L
Sbjct: 124 AIRGLSALQSLRLDANHITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTLQALT 183
Query: 177 LSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPG 236
L+ N ++ +P + L L LH+N++ SL + L L L + N++ P
Sbjct: 184 LALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNNLGEF-PQ 242
Query: 237 AFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELW 296
A LP+L L N ++ +P F + L + L++NPL+ + F + L L
Sbjct: 243 AIKALPSLKELGFHSNSISVIPDGAFDGNPLLRTIHLYDNPLSFVGNSAFHNLSDLHSLV 302
Query: 297 LNRTQLRTLPAAAFRNLSRLRYL-GVTLS-PRLSALPQGAFQGLGELQVLALHSNGLTAL 354
+ + F NL+ +L +TL+ ++S++P Q L+ L L N + L
Sbjct: 303 IRGASM----VQQFPNLTGTVHLESLTLTGTKISSIPNNLCQEQKMLRTLDLSYNNIRDL 358
Query: 355 PDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLT 414
P G L ++SL+RN++ + F+ L SL + L N + + F L +T
Sbjct: 359 PS--FNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPIT 416
Query: 415 EVLLGHN 421
+ + N
Sbjct: 417 NLDVSFN 423
Score = 80.5 bits (197), Expect = 4e-15
Identities = 55/177 (31%), Positives = 95/177 (53%), Gaps = 1/177 (0%)
Query: 246 SLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTL 305
+L +S N++ LP F + L L L N L+ + + L+ L L QL+T+
Sbjct: 61 ALDISMNNITQLPEDAFKNFPFLEELQLAGNDLSFIHPKALSGLKELKVLTLQNNQLKTV 120
Query: 306 PAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKL 365
P+ A R LS L+ L + + ++++P+ +F+GL +L+ L L N LT +P L L L
Sbjct: 121 PSEAIRGLSALQSLRLDAN-HITSVPEDSFEGLVQLRHLWLDDNSLTEVPVHPLSNLPTL 179
Query: 366 RQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422
+ ++L N++ ++P F NLSSL + L +N++ +L F L L + L +N+
Sbjct: 180 QALTLALNKISSIPDFAFTNLSSLVVLHLHNNKIRSLSQHCFDGLDNLETLDLNYNN 236
Score = 32.3 bits (72), Expect = 1.2
Identities = 21/83 (25%), Positives = 35/83 (42%)
Query: 93 TFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELA 152
+F+ L+ + L RN+I + ++ L L L N + I F L + L
Sbjct: 360 SFNGCHALEEISLQRNQIYQIKEGTFQGLISLRILDLSRNLIHEIHSRAFATLGPITNLD 419
Query: 153 LNQNQLDFLPASLFTNLENLKLL 175
++ N+L P L LKL+
Sbjct: 420 VSFNELTSFPTEGLNGLNQLKLV 442
>gi|54607118 leucine-rich repeats and immunoglobulin-like domains 1
[Homo sapiens]
Length = 1093
Score = 130 bits (328), Expect = 2e-30
Identities = 136/505 (26%), Positives = 219/505 (43%), Gaps = 71/505 (14%)
Query: 6 LLCAVLGLLRAQPF--------PCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILL 57
LL L LLR +P PC AC C D+ C G +A +
Sbjct: 18 LLLLWLLLLRLEPVTAAAGPRAPCAAACTCA-GDSLDCGGRGLAALP------------- 63
Query: 58 FGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLP--G 115
G L S + S L +S + +S + P F DL L+ + L+ N++T +P G
Sbjct: 64 -----GDLPSWTRS-------LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLG 111
Query: 116 ALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLL 175
A +V LFL HN +R ++ + + ++L+ L L+ N + + + F + +K L
Sbjct: 112 AASSHVV---SLFLQHNKIRSVEGSQLKAYLSLEVLDLSLNNITEVRNTCFPHGPPIKEL 168
Query: 176 DLSGNNLTHLPKGLL-GAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIA 234
+L+GN + L G G L L L NR+ L L LT+L +RN IR I
Sbjct: 169 NLAGNRIGTLELGAFDGLSRSLLTLRLSKNRITQLPVRAFK-LPRLTQLDLNRNRIRLIE 227
Query: 235 PGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAEL-PGVLFGEMGGLQ 293
F L +L L L RN+++ L F + +L L N L E+ G L+G + L
Sbjct: 228 GLTFQGLNSLEVLKLQRNNISKLTDGAFWGLSKMHVLHLEYNSLVEVNSGSLYG-LTALH 286
Query: 294 ELWLNRTQLRTLP-------------AAAFRNLSRLRYLGVTLSPRLSAL---------- 330
+L L+ + + +F NL+RL + LS L
Sbjct: 287 QLHLSNNSIARIHRKGWSFCQKLHELVLSFNNLTRLDEESLAELSSLSVLRLSHNSISHI 346
Query: 331 PQGAFQGLGELQVLALHSNGLTALPD---GLLRGLGKLRQVSLRRNRLRALPRALFRNLS 387
+GAF+GL L+VL L N ++ + G GL L +++L N+++++ + F L
Sbjct: 347 AEGAFKGLRSLRVLDLDHNEISGTIEDTSGAFSGLDSLSKLTLFGNKIKSVAKRAFSGLE 406
Query: 388 SLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEE 447
LE + L N + ++ D F + L E+ + +S+ CDC L WL ++
Sbjct: 407 GLEHLNLGGNAIRSVQFDAFVKMKNLKELHISSDSFLCDCQLKWLPPWLIGR--MLQAFV 464
Query: 448 PPRCAGPGAHAGLPLWALPGGDAEC 472
CA P + G ++++P C
Sbjct: 465 TATCAHPESLKGQSIFSVPPESFVC 489
>gi|12007646 nyctalopin precursor [Homo sapiens]
Length = 481
Score = 128 bits (322), Expect = 1e-29
Identities = 122/400 (30%), Positives = 169/400 (42%), Gaps = 46/400 (11%)
Query: 102 TLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFL 161
++R R + +P L + V ++ LD N LR + + F L +L+ L+L N L F+
Sbjct: 45 SVRCDRAGLLRVPAELPCEAVSID---LDRNGLRFLGERAFGTLPSLRRLSLRHNNLSFI 101
Query: 162 PASLFTNLENLKLLDLSGN-NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGAL 220
F L L L L+ N +L +L A ++L RL L + RL S+ LL L AL
Sbjct: 102 TPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFSVPERLLAELPAL 161
Query: 221 TELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAE 280
EL N R + PGA L NL+ L R + + S+ L L+L N +
Sbjct: 162 RELAAFDNLFRRV-PGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRA 220
Query: 281 LPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGE 340
+ FG+ G L+ L LN L LPA AF+GL
Sbjct: 221 VHAGAFGDCGVLEHLLLNDNLLAELPA-------------------------DAFRGLRR 255
Query: 341 LQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLE 400
L+ L L N L + L +L + L RN + + F+NLS L ++ L+ N+L
Sbjct: 256 LRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLT 315
Query: 401 TLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGL 460
L F L + L N W CDC L WLR + G CA PG+ AGL
Sbjct: 316 VLAWVAFQPGFFLGRLFLFRNPWCCDCR----LEWLRDWMEGSGRVTDVPCASPGSVAGL 371
Query: 461 PLWALPGG---DAECPGPR---------GPPPRPAADSSS 488
L + G D C P GP P PAA + S
Sbjct: 372 DLSQVTFGRSSDGLCVDPEELNLTTSSPGPSPEPAATTVS 411
Score = 86.7 bits (213), Expect = 5e-17
Identities = 82/307 (26%), Positives = 123/307 (40%), Gaps = 30/307 (9%)
Query: 21 CPPACKCVFRD---AAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQ 77
CP AC C + + +C + R+ A LP I L G L ++F + L+
Sbjct: 31 CPAACACSTVERGCSVRCDRAGLLRVPA-ELPCEAVSIDLDRNGLRFLGERAFGTLPSLR 89
Query: 78 RLMISDSHISAVAPGTFSDLIKLKTLRLSRN-------------------------KITH 112
RL + +++S + PG F L +L LRL+ N ++
Sbjct: 90 RLSLRHNNLSFITPGAFKGLPRLAELRLAHNGDLRYLHARTFAALSRLRRLDLAACRLFS 149
Query: 113 LPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENL 172
+P LL ++ L +L N R + + L NL L + +++ + +S L L
Sbjct: 150 VPERLLAELPALRELAAFDNLFRRVP-GALRGLANLTHAHLERGRIEAVASSSLQGLRRL 208
Query: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
+ L L N + + G G LE LLL+ N L L + L L L N +
Sbjct: 209 RSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLLAELPADAFRGLRRLRTLNLGGNALDR 268
Query: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292
+A F L L L L RN +AF+ F + L L L N L L V F L
Sbjct: 269 VARAWFADLAELELLYLDRNSIAFVEEGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFL 328
Query: 293 QELWLNR 299
L+L R
Sbjct: 329 GRLFLFR 335
Score = 68.6 bits (166), Expect = 1e-11
Identities = 50/162 (30%), Positives = 69/162 (42%)
Query: 91 PGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQE 150
PG L L L R +I + + L + L L L N +R + F L+
Sbjct: 175 PGALRGLANLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEH 234
Query: 151 LALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLD 210
L LN N L LPA F L L+ L+L GN L + + A+LE L L N + ++
Sbjct: 235 LLLNDNLLAELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVE 294
Query: 211 SGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRN 252
G +L L L + N + +A AF L L L RN
Sbjct: 295 EGAFQNLSGLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRN 336
Score = 62.8 bits (151), Expect = 8e-10
Identities = 50/154 (32%), Positives = 68/154 (44%)
Query: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKI 110
NLTH L + S S G+ L+ L + + + AV G F D L+ L L+ N +
Sbjct: 183 NLTHAHLERGRIEAVASSSLQGLRRLRSLSLQANRVRAVHAGAFGDCGVLEHLLLNDNLL 242
Query: 111 THLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLE 170
LP + L L L NAL + + F L L+ L L++N + F+ F NL
Sbjct: 243 AELPADAFRGLRRLRTLNLGGNALDRVARAWFADLAELELLYLDRNSIAFVEEGAFQNLS 302
Query: 171 NLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSN 204
L L L+GN LT L L RL L N
Sbjct: 303 GLLALHLNGNRLTVLAWVAFQPGFFLGRLFLFRN 336
>gi|51317373 netrin-G1 ligand [Homo sapiens]
Length = 640
Score = 128 bits (321), Expect = 2e-29
Identities = 85/258 (32%), Positives = 128/258 (49%), Gaps = 7/258 (2%)
Query: 181 NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDR 240
NL +P G+ L LH N++ + L L LQ RNHIR+I GAF+
Sbjct: 66 NLREVPDGI---STNTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNG 122
Query: 241 LPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR- 299
L NL++L L N L +P+ F++ L L L NP+ +P F + L+ L L
Sbjct: 123 LANLNTLELFDNRLTTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGEL 182
Query: 300 TQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLL 359
+L + AF LS LRYL + + L +P L +L L L N L+A+ G
Sbjct: 183 KRLSYISEGAFEGLSNLRYLNLAMC-NLREIPN--LTPLIKLDELDLSGNHLSAIRPGSF 239
Query: 360 RGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLG 419
+GL L+++ + +++++ + R F NL SL + L HN L LP D+F L L + L
Sbjct: 240 QGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTPLHHLERIHLH 299
Query: 420 HNSWRCDCGLGPFLGWLR 437
HN W C+C + W++
Sbjct: 300 HNPWNCNCDILWLSWWIK 317
Score = 112 bits (281), Expect = 7e-25
Identities = 82/272 (30%), Positives = 130/272 (47%), Gaps = 5/272 (1%)
Query: 7 LCAVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGRGVLQ 66
L V GL+RAQ CP C C + + R G+ TN + L +++
Sbjct: 35 LLVVAGLVRAQT--CPSVCSCSNQFSKVICVRKNLREVPDGISTNTRLLNLHENQIQIIK 92
Query: 67 SQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQ 126
SF + L+ L +S +HI + G F+ L L TL L N++T +P + L++
Sbjct: 93 VNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRLTTIPNGAFVYLSKLKE 152
Query: 127 LFLDHNALRGIDQNMFQKLVNLQELALNQ-NQLDFLPASLFTNLENLKLLDLSGNNLTHL 185
L+L +N + I F ++ +L+ L L + +L ++ F L NL+ L+L+ NL +
Sbjct: 153 LWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGLSNLRYLNLAMCNLREI 212
Query: 186 PKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLS 245
P L KL+ L L N L ++ G L L +L ++ I+ I AFD L +L
Sbjct: 213 PN--LTPLIKLDELDLSGNHLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLV 270
Query: 246 SLTLSRNHLAFLPSALFLHSHNLTLLTLFENP 277
+ L+ N+L LP LF H+L + L NP
Sbjct: 271 EINLAHNNLTLLPHDLFTPLHHLERIHLHHNP 302
Score = 92.8 bits (229), Expect = 7e-19
Identities = 75/252 (29%), Positives = 111/252 (44%), Gaps = 28/252 (11%)
Query: 147 NLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
N + L L++NQ+ + + F +L +L++L LS N++ + G A L L L NRL
Sbjct: 77 NTRLLNLHENQIQIIKVNSFKHLRHLEILQLSRNHIRTIEIGAFNGLANLNTLELFDNRL 136
Query: 207 VSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSR-NHLAFLPSALFLHS 265
++ +G L L EL N I SI AF+R+P+L L L L+++ F
Sbjct: 137 TTIPNGAFVYLSKLKELWLRNNPIESIPSYAFNRIPSLRRLDLGELKRLSYISEGAFEGL 196
Query: 266 HNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSP 325
NL L L L E+P + + L EL L+
Sbjct: 197 SNLRYLNLAMCNLREIPNLT--PLIKLDELDLS-------------------------GN 229
Query: 326 RLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRN 385
LSA+ G+FQGL LQ L + + + + L L +++L N L LP LF
Sbjct: 230 HLSAIRPGSFQGLMHLQKLWMIQSQIQVIERNAFDNLQSLVEINLAHNNLTLLPHDLFTP 289
Query: 386 LSSLESVQLDHN 397
L LE + L HN
Sbjct: 290 LHHLERIHLHHN 301
>gi|50263044 leucine-rich repeat neuronal 6A [Homo sapiens]
Length = 620
Score = 127 bits (320), Expect = 2e-29
Identities = 105/349 (30%), Positives = 166/349 (47%), Gaps = 6/349 (1%)
Query: 6 LLCAVLG-LLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGMGR-G 63
+L VLG +L CPP C+C +D A G+PT T +L G R
Sbjct: 26 ILLLVLGSVLSGSATGCPPRCECSAQDRAVLCHRKRFVAVPEGIPTE-TRLLDLGKNRIK 84
Query: 64 VLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVL 123
L F+ L+ L ++++ +SAV PG F++L L+TL L N++ +P + +
Sbjct: 85 TLNQDEFASFPHLEELELNENIVSAVEPGAFNNLFNLRTLGLRSNRLKLIPLGVFTGLSN 144
Query: 124 LEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLT 183
L +L + N + + MFQ L NL+ L + N L ++ F+ L +L+ L L NLT
Sbjct: 145 LTKLDISENKIVILLDYMFQDLYNLKSLEVGDNDLVYISHRAFSGLNSLEQLTLEKCNLT 204
Query: 184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQF-HRNHIRSIAPGAFDRLP 242
+P L L L L + ++ L L L+ H ++ ++ P L
Sbjct: 205 SIPTEALSHLHGLIVLRLRHLNINAIRDYSFKRLYRLKVLEISHWPYLDTMTPNCLYGL- 263
Query: 243 NLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQL 302
NL+SL+++ +L +P H L L L NP++ + G + E+ LQE+ L QL
Sbjct: 264 NLTSLSITHCNLTAVPYLAVRHLVYLRFLNLSYNPISTIEGSMLHELLRLQEIQLVGGQL 323
Query: 303 RTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGL 351
+ AFR L+ LR L V+ +L+ L + F +G L+ L L SN L
Sbjct: 324 AVVEPYAFRGLNYLRVLNVS-GNQLTTLEESVFHSVGNLETLILDSNPL 371
Score = 113 bits (283), Expect = 4e-25
Identities = 97/349 (27%), Positives = 162/349 (46%), Gaps = 9/349 (2%)
Query: 107 RNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLF 166
R + +P + + LL+ L N ++ ++Q+ F +L+EL LN+N + + F
Sbjct: 59 RKRFVAVPEGIPTETRLLD---LGKNRIKTLNQDEFASFPHLEELELNENIVSAVEPGAF 115
Query: 167 TNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFH 226
NL NL+ L L N L +P G+ + L +L + N++V L + L L L+
Sbjct: 116 NNLFNLRTLGLRSNRLKLIPLGVFTGLSNLTKLDISENKIVILLDYMFQDLYNLKSLEVG 175
Query: 227 RNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLF 286
N + I+ AF L +L LTL + +L +P+ H H L +L L + + F
Sbjct: 176 DNDLVYISHRAFSGLNSLEQLTLEKCNLTSIPTEALSHLHGLIVLRLRHLNINAIRDYSF 235
Query: 287 GEMGGLQELWLNR-TQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLA 345
+ L+ L ++ L T+ L+ L L +T L+A+P A + L L+ L
Sbjct: 236 KRLYRLKVLEISHWPYLDTMTPNCLYGLN-LTSLSIT-HCNLTAVPYLAVRHLVYLRFLN 293
Query: 346 LHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGD 405
L N ++ + +L L +L+++ L +L + FR L+ L + + NQL TL
Sbjct: 294 LSYNPISTIEGSMLHELLRLQEIQLVGGQLAVVEPYAFRGLNYLRVLNVSGNQLTTLEES 353
Query: 406 VFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGP 454
VF ++ L ++L N CDC L L R+ L + P CA P
Sbjct: 354 VFHSVGNLETLILDSNPLACDCRL---LWVFRRRWRLNFNRQQPTCATP 399
>gi|88702793 slit-like 2 [Homo sapiens]
Length = 673
Score = 125 bits (314), Expect = 1e-28
Identities = 114/373 (30%), Positives = 153/373 (41%), Gaps = 55/373 (14%)
Query: 155 QNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLL 214
+N + L A F L L+LLDLS N + LP G+ A L L L +NRL + +
Sbjct: 61 ENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETF 120
Query: 215 NSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLF 274
L L L +N IR I PGAFD L L L L N L LP L L LL L
Sbjct: 121 RGLRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLS 177
Query: 275 ENPLAEL-PGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQG 333
N L L PG+L N+ LR G+ L L +G
Sbjct: 178 HNSLLALEPGIL-----------------------DTANVEALRLAGLGLQQ----LDEG 210
Query: 334 AFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN-RLRALPRALFRNLSSLESV 392
F L L L + N L +P ++RGL L ++ L N R+ L L++L+ +
Sbjct: 211 LFSRLRNLHDLDVSDNQLERVPP-VIRGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQEL 269
Query: 393 QLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCA 452
+ + L+ LPGD+ G PRL + N + C C L F W+R+ + E RC
Sbjct: 270 DVSNLSLQALPGDLSGLFPRLRLLAAARNPFNCVCPLSWFGPWVRESHVTLASPEETRCH 329
Query: 453 GPGAHAGLPLWALPGGDAECPGPRG----PPPRPA------------------ADSSSEA 490
P +AG L L D CP P RP + ++EA
Sbjct: 330 FPPKNAGRLLLELDYADFGCPATTTTATVPTTRPVVREPTALSSSLAPTWLSPTEPATEA 389
Query: 491 PVHPALAPNSSEP 503
P P+ AP + P
Sbjct: 390 PSPPSTAPPTVGP 402
Score = 99.4 bits (246), Expect = 8e-21
Identities = 98/326 (30%), Positives = 137/326 (42%), Gaps = 33/326 (10%)
Query: 3 RGTLLCAVLGLLRAQPFP--CPPACKCVFRDAAQCSGGDVARISALGLPTNLTHILLFGM 60
R LL +L LL P CP C+C C+ + +P + + +F
Sbjct: 4 RVPLLLPLLLLLALGPGVQGCPSGCQCSQPQTVFCTARQGTTVPR-DVPPDTVGLYVFEN 62
Query: 61 GRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDK 120
G +L + SF+G+ LQ L +S + I+++ G F L L L L+ N++ +
Sbjct: 63 GITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEITNETFRG 122
Query: 121 MVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGN 180
+ LE+L+L N +R I F L L EL L N+L LP L L LLDLS N
Sbjct: 123 LRRLERLYLGKNRIRHIQPGAFDTLDRLLELKLQDNELRALPP---LRLPRLLLLDLSHN 179
Query: 181 NLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDR 240
+L L G+L A +E L L L LD GL F R
Sbjct: 180 SLLALEPGILDT-ANVEALRLAGLGLQQLDEGL------------------------FSR 214
Query: 241 LPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENP-LAELPGVLFGEMGGLQELWLNR 299
L NL L +S N L +P + LT L L N +A+L + LQEL ++
Sbjct: 215 LRNLHDLDVSDNQLERVPPVI-RGLRGLTRLRLAGNTRIAQLRPEDLAGLAALQELDVSN 273
Query: 300 TQLRTLPAAAFRNLSRLRYLGVTLSP 325
L+ LP RLR L +P
Sbjct: 274 LSLQALPGDLSGLFPRLRLLAAARNP 299
Score = 50.4 bits (119), Expect = 4e-06
Identities = 27/81 (33%), Positives = 45/81 (55%)
Query: 344 LALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLP 403
L + NG+T L G GL L+ + L +N++ +LP +F+ L++L ++ L N+L +
Sbjct: 57 LYVFENGITMLDAGSFAGLPGLQLLDLSQNQIASLPSGVFQPLANLSNLDLTANRLHEIT 116
Query: 404 GDVFGALPRLTEVLLGHNSWR 424
+ F L RL + LG N R
Sbjct: 117 NETFRGLRRLERLYLGKNRIR 137
>gi|209862903 leucine-rich repeats and immunoglobulin-like domains 3
isoform 1 [Homo sapiens]
Length = 1059
Score = 124 bits (310), Expect = 3e-28
Identities = 105/379 (27%), Positives = 183/379 (48%), Gaps = 9/379 (2%)
Query: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
+++ S S + L+ + ++++ + + P + L L+ N+I + L + L
Sbjct: 29 IKASSMSHLQSLREVKLNNNELETI-PNLGPVSANITLLSLAGNRIVEILPEHLKEFQSL 87
Query: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLEN-LKLLDLSGNNLT 183
E L L N + + Q F L L+ L LN N++ + F NL N L +L L+ N ++
Sbjct: 88 ETLDLSSNNISEL-QTAFPAL-QLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRIS 145
Query: 184 HLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPN 243
+P + +L+ L L+ N++ ++D LGAL L+ RN + + GAF L N
Sbjct: 146 AIPPKMFKLP-QLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSN 204
Query: 244 LSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLR 303
+ L L N+L + L L L +N + + + L EL L L
Sbjct: 205 MEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLS 264
Query: 304 TLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLT-ALPD--GLLR 360
L ++F LS L L + + R+S + AF+GL L+ L L +N ++ + D G
Sbjct: 265 RLDDSSFLGLSLLNTLHIG-NNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFS 323
Query: 361 GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH 420
GL KLR++ L+ NR+R++ + F L +LE + L N + +L G+ F + +L ++ L
Sbjct: 324 GLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNT 383
Query: 421 NSWRCDCGLGPFLGWLRQH 439
+S CDC L W+ ++
Sbjct: 384 SSLLCDCQLKWLPQWVAEN 402
Score = 107 bits (268), Expect = 2e-23
Identities = 105/376 (27%), Positives = 168/376 (44%), Gaps = 16/376 (4%)
Query: 36 SGGDVARISALG-LPTNLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTF 94
+ ++ I LG + N+T + L G + + L+ L +S ++IS + T
Sbjct: 46 NNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQ--TA 103
Query: 95 SDLIKLKTLRLSRNKITHLPGALLDKMV-LLEQLFLDHNALRGIDQNMFQKLVNLQELAL 153
++LK L L+ N++T + D + L L L+ N + I MF KL LQ L L
Sbjct: 104 FPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMF-KLPQLQHLEL 162
Query: 154 NQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGL 213
N+N++ + F L LK L + N +T L G + +E L L N L + G
Sbjct: 163 NRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGW 222
Query: 214 LNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTL 273
L L L EL +N I I+P A++ LS L L+ NHL+ L + FL L L +
Sbjct: 223 LYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLNTLHI 282
Query: 274 FENPLAELPGVLFGEMGGLQELWLNRTQLRTL---PAAAFRNLSRLRYLGVTLSPRLSAL 330
N ++ + F + L+ L L ++ AF L +LR L + R+ ++
Sbjct: 283 GNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRL-ILQGNRIRSI 341
Query: 331 PQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN------RLRALPR-ALF 383
+ AF GL L+ L L N + +L + KL+Q+ L + +L+ LP+
Sbjct: 342 TKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAE 401
Query: 384 RNLSSLESVQLDHNQL 399
N S + H QL
Sbjct: 402 NNFQSFVNASCAHPQL 417
Score = 30.8 bits (68), Expect = 3.4
Identities = 14/34 (41%), Positives = 22/34 (64%)
Query: 370 LRRNRLRALPRALFRNLSSLESVQLDHNQLETLP 403
L NRL + + +L SL V+L++N+LET+P
Sbjct: 21 LSHNRLSFIKASSMSHLQSLREVKLNNNELETIP 54
>gi|30425563 reticulon 4 receptor-like 2 [Homo sapiens]
Length = 420
Score = 120 bits (302), Expect = 3e-27
Identities = 101/278 (36%), Positives = 132/278 (47%), Gaps = 11/278 (3%)
Query: 216 SLGALTELQFHRNH-IRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLF 274
SL T+ F +N+ IR++ PG F NL +L L N+L+ + F H L L L
Sbjct: 57 SLPPSTQRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLG 114
Query: 275 ENP-LAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQG 333
+N L L F + LQ L L R QL +LP FR L L+YL + + L L
Sbjct: 115 DNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLH-LQDD 173
Query: 334 AFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQ 393
F L L L LH N L L + + RGLG L ++ L NRL+ + RA FR LS L +
Sbjct: 174 LFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILY 233
Query: 394 LDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAG 453
L +N L +LPG+ LP L + L N W CDC P W ++ V + CA
Sbjct: 234 LFNNSLASLPGEALADLPSLEFLRLNANPWACDCRARPLWAWFQR--ARVSSSD-VTCAT 290
Query: 454 PGAHAGLPLWALPGGDAE-CP--GPRGPPPRPAADSSS 488
P G L AL D + CP P P R +SSS
Sbjct: 291 PPERQGRDLRALREADFQACPPAAPTRPGSRARGNSSS 328
Score = 102 bits (254), Expect = 9e-22
Identities = 76/220 (34%), Positives = 106/220 (48%), Gaps = 8/220 (3%)
Query: 66 QSQSFSGMTV-----LQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDK 120
Q+ +FS + + QRL + ++ I + PGTF L TL L N ++ +
Sbjct: 47 QANNFSSVPLSLPPSTQRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRH 104
Query: 121 MVLLEQLFL-DHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSG 179
+ LE+L L D+ LR ++ + FQ L LQ L L + QL LP ++F L +L+ L L
Sbjct: 105 LQALEELDLGDNRHLRSLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQE 164
Query: 180 NNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFD 239
N+L HL L A L L LH NRL L + LG+L L H N ++ + AF
Sbjct: 165 NSLLHLQDDLFADLANLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFR 224
Query: 240 RLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLA 279
L L+ L L N LA LP +L L L NP A
Sbjct: 225 GLSRLTILYLFNNSLASLPGEALADLPSLEFLRLNANPWA 264
Score = 72.4 bits (176), Expect = 1e-12
Identities = 69/202 (34%), Positives = 91/202 (45%), Gaps = 4/202 (1%)
Query: 149 QELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNR-LV 207
Q L L N + L F + NL L L NNL+ + G LE L L NR L
Sbjct: 63 QRLFLQNNLIRTLRPGTFGS--NLLTLWLFSNNLSTIYPGTFRHLQALEELDLGDNRHLR 120
Query: 208 SLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHN 267
SL+ L L L +R + S+ F L +L L L N L L LF N
Sbjct: 121 SLEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLAN 180
Query: 268 LTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRL 327
L+ L L N L L +F +G L L L+ +L+ + AAFR LSRL L + L
Sbjct: 181 LSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTIL-YLFNNSL 239
Query: 328 SALPQGAFQGLGELQVLALHSN 349
++LP A L L+ L L++N
Sbjct: 240 ASLPGEALADLPSLEFLRLNAN 261
Score = 68.9 bits (167), Expect = 1e-11
Identities = 45/140 (32%), Positives = 70/140 (50%)
Query: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
L+ +F G+ LQ L + +S++ F L+ L+ L L N + HL L + L
Sbjct: 122 LEPDTFQGLERLQSLHLYRCQLSSLPGNIFRGLVSLQYLYLQENSLLHLQDDLFADLANL 181
Query: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
LFL N LR + +++F+ L +L L L+ N+L + + F L L +L L N+L
Sbjct: 182 SHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSLAS 241
Query: 185 LPKGLLGAQAKLERLLLHSN 204
LP L LE L L++N
Sbjct: 242 LPGEALADLPSLEFLRLNAN 261
Score = 43.9 bits (102), Expect = 4e-04
Identities = 27/82 (32%), Positives = 39/82 (47%)
Query: 51 NLTHILLFGMGRGVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKI 110
NL+H+ L G +L F G+ L RL++ + + V F L +L L L N +
Sbjct: 180 NLSHLFLHGNRLRLLTEHVFRGLGSLDRLLLHGNRLQGVHRAAFRGLSRLTILYLFNNSL 239
Query: 111 THLPGALLDKMVLLEQLFLDHN 132
LPG L + LE L L+ N
Sbjct: 240 ASLPGEALADLPSLEFLRLNAN 261
>gi|122937309 leucine rich repeat containing 4B [Homo sapiens]
Length = 713
Score = 119 bits (299), Expect = 6e-27
Identities = 81/241 (33%), Positives = 118/241 (48%), Gaps = 4/241 (1%)
Query: 199 LLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLP 258
L L N + + + L L LQ +N +R I GAF+ LP+L++L L N L +P
Sbjct: 91 LNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVP 150
Query: 259 SALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQ-LRTLPAAAFRNLSRLR 317
+ F + L L L NP+ +P F + L+ L L + L + AAF L LR
Sbjct: 151 TQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLR 210
Query: 318 YLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRA 377
YL + + L +P L L+ L L N L + G +GL LR++ L ++
Sbjct: 211 YLNLGMC-NLKDIPN--LTALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVAT 267
Query: 378 LPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWRCDCGLGPFLGWLR 437
+ R F +L SLE + L HN L +LP D+F L RL V L HN W C+C + WL+
Sbjct: 268 IERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHNPWHCNCDVLWLSWWLK 327
Query: 438 Q 438
+
Sbjct: 328 E 328
Score = 114 bits (285), Expect = 2e-25
Identities = 80/259 (30%), Positives = 130/259 (50%), Gaps = 5/259 (1%)
Query: 21 CPPACKCVFRDAAQ-CSGGDVARISALGLPTNLTHILLFGMGRGVLQSQSFSGMTVLQRL 79
CP AC C + + C+ D+A + A +P N ++ L G V+++ +F + L+ L
Sbjct: 57 CPVACSCSNQASRVICTRRDLAEVPA-SIPVNTRYLNLQENGIQVIRTDTFKHLRHLEIL 115
Query: 80 MISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQ 139
+S + + + G F+ L L TL L N++T +P + + L +L+L +N + I
Sbjct: 116 QLSKNLVRKIEVGAFNGLPSLNTLELFDNRLTTVPTQAFEYLSKLRELWLRNNPIESIPS 175
Query: 140 NMFQKLVNLQELALNQ-NQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLER 198
F ++ +L+ L L + +L+++ + F L NL+ L+L NL +P L A +LE
Sbjct: 176 YAFNRVPSLRRLDLGELKRLEYISEAAFEGLVNLRYLNLGMCNLKDIPN--LTALVRLEE 233
Query: 199 LLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLP 258
L L NRL + G L +L +L + +I AFD L +L L LS N+L LP
Sbjct: 234 LELSGNRLDLIRPGSFQGLTSLRKLWLMHAQVATIERNAFDDLKSLEELNLSHNNLMSLP 293
Query: 259 SALFLHSHNLTLLTLFENP 277
LF H L + L NP
Sbjct: 294 HDLFTPLHRLERVHLNHNP 312
Score = 88.2 bits (217), Expect = 2e-17
Identities = 69/229 (30%), Positives = 109/229 (47%), Gaps = 4/229 (1%)
Query: 146 VNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNR 205
VN + L L +N + + F +L +L++L LS N + + G L L L NR
Sbjct: 86 VNTRYLNLQENGIQVIRTDTFKHLRHLEILQLSKNLVRKIEVGAFNGLPSLNTLELFDNR 145
Query: 206 LVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSR-NHLAFLPSALFLH 264
L ++ + L L EL N I SI AF+R+P+L L L L ++ A F
Sbjct: 146 LTTVPTQAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLRRLDLGELKRLEYISEAAFEG 205
Query: 265 SHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLS 324
NL L L L ++P + + L+EL L+ +L + +F+ L+ LR L + +
Sbjct: 206 LVNLRYLNLGMCNLKDIPNLT--ALVRLEELELSGNRLDLIRPGSFQGLTSLRKLWL-MH 262
Query: 325 PRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN 373
+++ + + AF L L+ L L N L +LP L L +L +V L N
Sbjct: 263 AQVATIERNAFDDLKSLEELNLSHNNLMSLPHDLFTPLHRLERVHLNHN 311
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 115 bits (289), Expect = 8e-26
Identities = 122/385 (31%), Positives = 175/385 (45%), Gaps = 47/385 (12%)
Query: 41 ARISALGLPTNLTHILLF------GMGRGVLQSQSFSGMTV------LQRLMISDSHISA 88
A + A L +NL + L G G L+S + + + ++ L + ++ +
Sbjct: 18 AALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPANLGDIEALNLGNNGLEE 77
Query: 89 VAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNL 148
V G S L L+ L L RN+ LP A+ + L +L + HN L + + L L
Sbjct: 78 VPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALREL 137
Query: 149 QELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVS 208
++L L+ NQL LPA L L +L+ LD+S N L HLP L ++L L + N+L +
Sbjct: 138 RKLNLSHNQLPALPAQLGA-LAHLEELDVSFNRLAHLPDS-LSCLSRLRTLDVDHNQLTA 195
Query: 209 LDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNL 268
LL L AL EL N +R + P L L L LS L LP+
Sbjct: 196 FPRQLL-QLVALEELDVSSNRLRGL-PEDISALRALKILWLSGAELGTLPAG-------- 245
Query: 269 TLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLS 328
F E+ L+ L L+ L+ LPA F L RL+ L LS L
Sbjct: 246 -----------------FCELASLESLMLDNNGLQALPA-QFSCLQRLKML--NLSSNLF 285
Query: 329 ALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSS 388
A L L+ L L N LT++P L+ GLG+L + L NR+R LP ++ L+
Sbjct: 286 EEFPAALLPLAGLEELYLSRNQLTSVP-SLISGLGRLLTLWLDNNRIRYLPDSIV-ELTG 343
Query: 389 LESVQLDHNQLETLPGDVFGALPRL 413
LE + L NQ+ LP D FG L R+
Sbjct: 344 LEELVLQGNQIAVLP-DHFGQLSRV 367
Score = 87.4 bits (215), Expect = 3e-17
Identities = 88/281 (31%), Positives = 124/281 (44%), Gaps = 33/281 (11%)
Query: 168 NLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHR 227
NL +++ L+L N L +P+GL A L L+L NR L + LTEL
Sbjct: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
Query: 228 NHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVL-- 285
N + ++ L L L LS N L LP+ L +H L L + N LA LP L
Sbjct: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAH-LEELDVSFNRLAHLPDSLSC 179
Query: 286 --------------------FGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGV--TL 323
++ L+EL ++ +LR LP ++S LR L +
Sbjct: 180 LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLP----EDISALRALKILWLS 235
Query: 324 SPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALF 383
L LP G F L L+ L L +NGL ALP L +L+ ++L N P AL
Sbjct: 236 GAELGTLPAG-FCELASLESLMLDNNGLQALP-AQFSCLQRLKMLNLSSNLFEEFPAALL 293
Query: 384 RNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
L+ LE + L NQL ++P + G L RL + L +N R
Sbjct: 294 -PLAGLEELYLSRNQLTSVPSLISG-LGRLLTLWLDNNRIR 332
>gi|22749183 leucine rich repeat and Ig domain containing 2 [Homo
sapiens]
Length = 606
Score = 115 bits (288), Expect = 1e-25
Identities = 102/358 (28%), Positives = 167/358 (46%), Gaps = 31/358 (8%)
Query: 9 AVLGLLRAQPFPCPPACKCVFRDAAQCSGGDVARISALGLPTNL---THILLFGMGR-GV 64
AV+ + CP C+C +AQ R + +P + T IL R
Sbjct: 16 AVVLIFMGSTIGCPARCEC----SAQNKSVSCHRRRLIAIPEGIPIETKILDLSKNRLKS 71
Query: 65 LQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLL 124
+ + F +L+ + +SD+ I+ V PG F++L L++LRL N++ +P + + L
Sbjct: 72 VNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNRLKLVPLGVFTGLSNL 131
Query: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
+L + N + + MFQ L NL+ L + N L ++ F+ L +L+ L L NLT
Sbjct: 132 TKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGLLSLEQLTLEKCNLTA 191
Query: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLN----SLGALTELQFHRNHIRSIAPGAFDR 240
+P L H L+SL LN + A L FH H+ D
Sbjct: 192 VP----------TEALSHLRSLISLHLKHLNINNMPVYAFKRL-FHLKHLEIDYWPLLDM 240
Query: 241 LP-------NLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQ 293
+P NL+SL+++ +L+ +P F H LT L L NP++ + +F ++ LQ
Sbjct: 241 MPANSLYGLNLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNPISTIEAGMFSDLIRLQ 300
Query: 294 ELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGL 351
EL + QLRT+ +F+ L LR L V+ + L L + F L+VL++++N L
Sbjct: 301 ELHIVGAQLRTIEPHSFQGLRFLRVLNVSQN-LLETLEENVFSSPRALEVLSINNNPL 357
Score = 113 bits (282), Expect = 5e-25
Identities = 104/360 (28%), Positives = 163/360 (45%), Gaps = 34/360 (9%)
Query: 98 IKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQ 157
I+ K L LS+N++ + LLE++ L N + ++ F L NL+ L L N+
Sbjct: 57 IETKILDLSKNRLKSVNPEEFISYPLLEEIDLSDNIIANVEPGAFNNLFNLRSLRLKGNR 116
Query: 158 LDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSL 217
L +P +FT L NL LD+S N + L + L+ L + N LV + + L
Sbjct: 117 LKLVPLGVFTGLSNLTKLDISENKIVILLDYMFQDLHNLKSLEVGDNDLVYISHRAFSGL 176
Query: 218 GALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENP 277
+L +L + ++ ++ A L +L SL L ++ +P F +L L + P
Sbjct: 177 LSLEQLTLEKCNLTAVPTEALSHLRSLISLHLKHLNINNMPVYAFKRLFHLKHLEIDYWP 236
Query: 278 LAEL--PGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAF 335
L ++ L+G L L + T L T+P AF++L L +L ++ +P +S + G F
Sbjct: 237 LLDMMPANSLYGL--NLTSLSVTNTNLSTVPFLAFKHLVYLTHLNLSYNP-ISTIEAGMF 293
Query: 336 QGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLD 395
L LQ LH G +LR + F+ L L + +
Sbjct: 294 SDLIRLQ--ELHIVGA----------------------QLRTIEPHSFQGLRFLRVLNVS 329
Query: 396 HNQLETLPGDVFGALPRLTEVL-LGHNSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGP 454
N LETL +VF + PR EVL + +N CDC L L L++ L G + P CAGP
Sbjct: 330 QNLLETLEENVFSS-PRALEVLSINNNPLACDCRL---LWILQRQPTLQFGGQQPMCAGP 385
>gi|15029530 leucine rich repeat containing 4 [Homo sapiens]
Length = 653
Score = 115 bits (288), Expect = 1e-25
Identities = 86/295 (29%), Positives = 132/295 (44%), Gaps = 8/295 (2%)
Query: 182 LTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRL 241
L+ +P+G+ + L L N + + + L L LQ RN IR I GAF+ L
Sbjct: 66 LSEVPQGI---PSNTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGL 122
Query: 242 PNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR-T 300
+L++L L N L +PS F + L L L NP+ +P F + L L L
Sbjct: 123 ASLNTLELFDNWLTVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELK 182
Query: 301 QLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLR 360
+L + AF L L+YL + + + +P L L+ L + N + G
Sbjct: 183 KLEYISEGAFEGLFNLKYLNLGMC-NIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFH 239
Query: 361 GLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGH 420
GL L+++ + +++ + R F L+SL + L HN L +LP D+F L L E+ L H
Sbjct: 240 GLSSLKKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHH 299
Query: 421 NSWRCDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALPGGDAECPGP 475
N W CDC + WLR+++ RC P G L + +C P
Sbjct: 300 NPWNCDCDILWLAWWLREYIP-TNSTCCGRCHAPMHMRGRYLVEVDQASFQCSAP 353
Score = 91.3 bits (225), Expect = 2e-18
Identities = 69/228 (30%), Positives = 107/228 (46%), Gaps = 4/228 (1%)
Query: 147 NLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRL 206
N + L L +N + + A F +L +L++L L N++ + G A L L L N L
Sbjct: 76 NTRYLNLMENNIQMIQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWL 135
Query: 207 VSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSR-NHLAFLPSALFLHS 265
+ SG L L EL N I SI AF+R+P+L L L L ++ F
Sbjct: 136 TVIPSGAFEYLSKLRELWLRNNPIESIPSYAFNRVPSLMRLDLGELKKLEYISEGAFEGL 195
Query: 266 HNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSP 325
NL L L + ++P + + GL+EL ++ + +F LS L+ L V ++
Sbjct: 196 FNLKYLNLGMCNIKDMPNLT--PLVGLEELEMSGNHFPEIRPGSFHGLSSLKKLWV-MNS 252
Query: 326 RLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRN 373
++S + + AF GL L L L N L++LP L L L ++ L N
Sbjct: 253 QVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHN 300
Score = 75.9 bits (185), Expect = 9e-14
Identities = 74/297 (24%), Positives = 120/297 (40%), Gaps = 51/297 (17%)
Query: 6 LLCAVLGLLRAQPFPCPPACKCVFR-DAAQCSGGDVARISALGLPTN------------- 51
L A+ A P CP C C + C+ ++ + G+P+N
Sbjct: 31 LCAAIAAAASAGPQNCPSVCSCSNQFSKVVCTRRGLSEVPQ-GIPSNTRYLNLMENNIQM 89
Query: 52 --------LTHILLFGMGRGVLQS---QSFSGMTVLQRLMISDSHISAVAPGTFSDLIKL 100
L H+ + +GR ++ +F+G+ L L + D+ ++ + G F L KL
Sbjct: 90 IQADTFRHLHHLEVLQLGRNSIRQIEVGAFNGLASLNTLELFDNWLTVIPSGAFEYLSKL 149
Query: 101 KTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDF 160
+ L L N I +P +++ L +L +L EL +L++
Sbjct: 150 RELWLRNNPIESIPSYAFNRVPSLMRL-------------------DLGEL----KKLEY 186
Query: 161 LPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGAL 220
+ F L NLK L+L N+ +P L LE L + N + G + L +L
Sbjct: 187 ISEGAFEGLFNLKYLNLGMCNIKDMPN--LTPLVGLEELEMSGNHFPEIRPGSFHGLSSL 244
Query: 221 TELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENP 277
+L + + I AFD L +L L L+ N+L+ LP LF L L L NP
Sbjct: 245 KKLWVMNSQVSLIERNAFDGLASLVELNLAHNNLSSLPHDLFTPLRYLVELHLHHNP 301
>gi|153791507 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 115 bits (287), Expect = 1e-25
Identities = 89/301 (29%), Positives = 143/301 (47%), Gaps = 2/301 (0%)
Query: 77 QRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRG 136
Q L++ ++I+ + T + L L LS+N ++ + + KM L ++L+ N L
Sbjct: 72 QILLLQTNNIAKIEYSTDFP-VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
Query: 137 IDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKL 196
+ + +L NLQEL +N N L + F L NL L L+ N L + A L
Sbjct: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNL 190
Query: 197 ERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAF 256
E L++ N ++ + L L L ++ I A L NL S++ N L
Sbjct: 191 EILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIK 250
Query: 257 LPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR-TQLRTLPAAAFRNLSR 315
+P NL L L +NP+ + F M L+EL +N +L ++ + A NL
Sbjct: 251 VPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPD 310
Query: 316 LRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRL 375
LR + T +PRLS + AF L +L+ L L+SN L+AL G + L L+++S+ N +
Sbjct: 311 LRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPI 370
Query: 376 R 376
R
Sbjct: 371 R 371
Score = 102 bits (255), Expect = 7e-22
Identities = 91/311 (29%), Positives = 140/311 (45%), Gaps = 27/311 (8%)
Query: 119 DKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLS 178
D V L L L N L + +K+ L + L +N+L LP + L NL+ L ++
Sbjct: 89 DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYIN 148
Query: 179 GNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAF 238
N L+ + G L RL L+SNRL ++S ++L L L N I I F
Sbjct: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208
Query: 239 DRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLN 298
L NL SL ++ +L +P + NL ++ ++N L ++P V ++ L+ L LN
Sbjct: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268
Query: 299 RTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGL 358
+ + + F N+ L+ LG+ P L +++ S + LPD
Sbjct: 269 KNPINRIRRGDFSNMLHLKELGINNMPEL----------------ISIDSLAVDNLPD-- 310
Query: 359 LRGLGKLRQVSLRRN-RLRAL-PRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEV 416
LR++ N RL + P A FR L LES+ L+ N L L +LP L E+
Sbjct: 311 ------LRKIEATNNPRLSYIHPNAFFR-LPKLESLMLNSNALSALYHGTIESLPNLKEI 363
Query: 417 LLGHNSWRCDC 427
+ N RCDC
Sbjct: 364 SIHSNPIRCDC 374
>gi|153792651 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 115 bits (287), Expect = 1e-25
Identities = 89/301 (29%), Positives = 143/301 (47%), Gaps = 2/301 (0%)
Query: 77 QRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRG 136
Q L++ ++I+ + T + L L LS+N ++ + + KM L ++L+ N L
Sbjct: 72 QILLLQTNNIAKIEYSTDFP-VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
Query: 137 IDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKL 196
+ + +L NLQEL +N N L + F L NL L L+ N L + A L
Sbjct: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNL 190
Query: 197 ERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAF 256
E L++ N ++ + L L L ++ I A L NL S++ N L
Sbjct: 191 EILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIK 250
Query: 257 LPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR-TQLRTLPAAAFRNLSR 315
+P NL L L +NP+ + F M L+EL +N +L ++ + A NL
Sbjct: 251 VPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPD 310
Query: 316 LRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRL 375
LR + T +PRLS + AF L +L+ L L+SN L+AL G + L L+++S+ N +
Sbjct: 311 LRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPI 370
Query: 376 R 376
R
Sbjct: 371 R 371
Score = 102 bits (255), Expect = 7e-22
Identities = 91/311 (29%), Positives = 140/311 (45%), Gaps = 27/311 (8%)
Query: 119 DKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLS 178
D V L L L N L + +K+ L + L +N+L LP + L NL+ L ++
Sbjct: 89 DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYIN 148
Query: 179 GNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAF 238
N L+ + G L RL L+SNRL ++S ++L L L N I I F
Sbjct: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208
Query: 239 DRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLN 298
L NL SL ++ +L +P + NL ++ ++N L ++P V ++ L+ L LN
Sbjct: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268
Query: 299 RTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGL 358
+ + + F N+ L+ LG+ P L +++ S + LPD
Sbjct: 269 KNPINRIRRGDFSNMLHLKELGINNMPEL----------------ISIDSLAVDNLPD-- 310
Query: 359 LRGLGKLRQVSLRRN-RLRAL-PRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEV 416
LR++ N RL + P A FR L LES+ L+ N L L +LP L E+
Sbjct: 311 ------LRKIEATNNPRLSYIHPNAFFR-LPKLESLMLNSNALSALYHGTIESLPNLKEI 363
Query: 417 LLGHNSWRCDC 427
+ N RCDC
Sbjct: 364 SIHSNPIRCDC 374
>gi|153792227 leucine rich repeat neuronal 3 [Homo sapiens]
Length = 708
Score = 115 bits (287), Expect = 1e-25
Identities = 89/301 (29%), Positives = 143/301 (47%), Gaps = 2/301 (0%)
Query: 77 QRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRG 136
Q L++ ++I+ + T + L L LS+N ++ + + KM L ++L+ N L
Sbjct: 72 QILLLQTNNIAKIEYSTDFP-VNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTE 130
Query: 137 IDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKL 196
+ + +L NLQEL +N N L + F L NL L L+ N L + A L
Sbjct: 131 LPEKCLSELSNLQELYINHNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNL 190
Query: 197 ERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAF 256
E L++ N ++ + L L L ++ I A L NL S++ N L
Sbjct: 191 EILMIGENPIIRIKDMNFKPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIK 250
Query: 257 LPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNR-TQLRTLPAAAFRNLSR 315
+P NL L L +NP+ + F M L+EL +N +L ++ + A NL
Sbjct: 251 VPHVALQKVVNLKFLDLNKNPINRIRRGDFSNMLHLKELGINNMPELISIDSLAVDNLPD 310
Query: 316 LRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRL 375
LR + T +PRLS + AF L +L+ L L+SN L+AL G + L L+++S+ N +
Sbjct: 311 LRKIEATNNPRLSYIHPNAFFRLPKLESLMLNSNALSALYHGTIESLPNLKEISIHSNPI 370
Query: 376 R 376
R
Sbjct: 371 R 371
Score = 102 bits (255), Expect = 7e-22
Identities = 91/311 (29%), Positives = 140/311 (45%), Gaps = 27/311 (8%)
Query: 119 DKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLS 178
D V L L L N L + +K+ L + L +N+L LP + L NL+ L ++
Sbjct: 89 DFPVNLTGLDLSQNNLSSVTNINVKKMPQLLSVYLEENKLTELPEKCLSELSNLQELYIN 148
Query: 179 GNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAF 238
N L+ + G L RL L+SNRL ++S ++L L L N I I F
Sbjct: 149 HNLLSTISPGAFIGLHNLLRLHLNSNRLQMINSKWFDALPNLEILMIGENPIIRIKDMNF 208
Query: 239 DRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLN 298
L NL SL ++ +L +P + NL ++ ++N L ++P V ++ L+ L LN
Sbjct: 209 KPLINLRSLVIAGINLTEIPDNALVGLENLESISFYDNRLIKVPHVALQKVVNLKFLDLN 268
Query: 299 RTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGL 358
+ + + F N+ L+ LG+ P L +++ S + LPD
Sbjct: 269 KNPINRIRRGDFSNMLHLKELGINNMPEL----------------ISIDSLAVDNLPD-- 310
Query: 359 LRGLGKLRQVSLRRN-RLRAL-PRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEV 416
LR++ N RL + P A FR L LES+ L+ N L L +LP L E+
Sbjct: 311 ------LRKIEATNNPRLSYIHPNAFFR-LPKLESLMLNSNALSALYHGTIESLPNLKEI 363
Query: 417 LLGHNSWRCDC 427
+ N RCDC
Sbjct: 364 SIHSNPIRCDC 374
>gi|157426829 leucine rich repeat and Ig domain containing 3 [Homo
sapiens]
Length = 592
Score = 114 bits (286), Expect = 2e-25
Identities = 104/354 (29%), Positives = 167/354 (47%), Gaps = 14/354 (3%)
Query: 6 LLCAVLGLLRAQPFP---CPPACKCVFRD-AAQCSGGDVARISAL--GLPTNLTHILLFG 59
+L L LL A P P CP C+C + A C+ R++A+ G+P T +L
Sbjct: 7 VLSLPLLLLPAAPPPAGGCPARCECTVQTRAVACTR---RRLTAVPDGIPAE-TRLLELS 62
Query: 60 MGR-GVLQSQSFSGMTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNKITHLPGALL 118
R L + + L+ L +S++ I+ V PG F++L +L+ LRL N++ +P +
Sbjct: 63 RNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKLIPPGVF 122
Query: 119 DKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLS 178
++ L L L N L + FQ L +L+ L + N L F+ F L L+ L L
Sbjct: 123 TRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLALEELTLE 182
Query: 179 GNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHR-NHIRSIAPGA 237
NLT L LG L L L + SL+ L L L+ + +A G+
Sbjct: 183 RCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLEEVAAGS 242
Query: 238 FDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWL 297
L NL+SL+++ ++ +P+A H +LT L L NP++ +P F ++ L+EL L
Sbjct: 243 LRGL-NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVRLRELHL 301
Query: 298 NRTQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGL 351
L + AF L ++R L ++ + LS L + F + L+ L + N L
Sbjct: 302 AGALLAVVEPQAFLGLRQIRLLNLS-NNLLSTLEESTFHSVNTLETLRVDGNPL 354
Score = 99.0 bits (245), Expect = 1e-20
Identities = 95/342 (27%), Positives = 136/342 (39%), Gaps = 52/342 (15%)
Query: 173 KLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRS 232
+LL+LS N + L G L A LE L L N + ++ G +L L L+ N ++
Sbjct: 57 RLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANLPRLRVLRLRGNQLKL 116
Query: 233 IAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGL 292
I PG F RL NL+ L LS N L L F H+L L + +N L + F + L
Sbjct: 117 IPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDNDLVFVSRRAFAGLLAL 176
Query: 293 QELWLNRTQLRTLPAAA------------------------FRNLSRLRYLGVTLSPRLS 328
+EL L R L L + FR L L +L + P L
Sbjct: 177 EELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRLPGLLHLEIDNWPLLE 236
Query: 329 ALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSS 388
+ G+ +GL + H+N +TA+P LR L ++L N + +PR FR+L
Sbjct: 237 EVAAGSLRGLNLTSLSVTHTN-ITAVPAAALRHQAHLTCLNLSHNPISTVPRGSFRDLVR 295
Query: 389 LES------------------------VQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
L + L +N L TL F ++ L + + N
Sbjct: 296 LRELHLAGALLAVVEPQAFLGLRQIRLLNLSNNLLSTLEESTFHSVNTLETLRVDGNPLA 355
Query: 425 CDCGLGPFLGWLRQHLGLVGGEEPPRCAGPGAHAGLPLWALP 466
CDC L L +++ L P CA P G L LP
Sbjct: 356 CDCRL---LWIVQRRKTLNFDGRLPACATPAEVRGDALRNLP 394
Score = 92.4 bits (228), Expect = 1e-18
Identities = 83/261 (31%), Positives = 112/261 (42%), Gaps = 28/261 (10%)
Query: 182 LTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRL 241
LT +P G+ A+ L L NR+ L+ G L +L AL EL N I + PGAF L
Sbjct: 45 LTAVPDGI---PAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFANL 101
Query: 242 PNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQ 301
P L L L N L +P +F NLTLL L EN L L F ++ L+ L +
Sbjct: 102 PRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSENKLVILLDYTFQDLHSLRRLEVGDND 161
Query: 302 LRTLPAAAFRNLSRLRYLGVTLS--PRLSALPQGAFQGLGELQ-----VLALHSNGLTAL 354
L + AF L L L + LS G + LG L+ + +L L
Sbjct: 162 LVFVSRRAFAGLLALEELTLERCNLTALSGESLGHLRSLGALRLRHLAIASLEDQNFRRL 221
Query: 355 PD-----------------GLLRGLGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHN 397
P G LRGL L +S+ + A+P A R+ + L + L HN
Sbjct: 222 PGLLHLEIDNWPLLEEVAAGSLRGL-NLTSLSVTHTNITAVPAAALRHQAHLTCLNLSHN 280
Query: 398 QLETLPGDVFGALPRLTEVLL 418
+ T+P F L RL E+ L
Sbjct: 281 PISTVPRGSFRDLVRLRELHL 301
Score = 45.1 bits (105), Expect = 2e-04
Identities = 32/96 (33%), Positives = 46/96 (47%), Gaps = 3/96 (3%)
Query: 326 RLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRN 385
RL+A+P G E ++L L N + L G L L L ++ L N + + F N
Sbjct: 44 RLTAVPDGI---PAETRLLELSRNRIRCLNPGDLAALPALEELDLSENAIAHVEPGAFAN 100
Query: 386 LSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
L L ++L NQL+ +P VF L LT + L N
Sbjct: 101 LPRLRVLRLRGNQLKLIPPGVFTRLDNLTLLDLSEN 136
>gi|42544233 leucine rich repeat neuronal 2 [Homo sapiens]
Length = 713
Score = 114 bits (285), Expect = 2e-25
Identities = 110/388 (28%), Positives = 162/388 (41%), Gaps = 41/388 (10%)
Query: 6 LLCAVLGLLRAQPF-----PCPPACKCVFR-------DAAQCSGGDVARISALGLPTNL- 52
LL V G A P PCPP C C R + + D + +P L
Sbjct: 9 LLAWVAGATAAVPVVPWHVPCPPQCACQIRPWYTPRSSYREATTVDCNDLFLTAVPPALP 68
Query: 53 --THILLFGMGRGVLQSQSFSG-MTVLQRLMISDSHISAVAPGTFSDLIKLKTLRLSRNK 109
T LL V QS G + L L +S + S F L +L +L L N+
Sbjct: 69 AGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQ 128
Query: 110 ITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNL 169
+T L + L++L+L+HN L I F L NL L LN N L + + F L
Sbjct: 129 LTRLEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEML 188
Query: 170 ENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNH 229
NL++L + GN + + A L L+L L + L L +L L F+ N
Sbjct: 189 PNLEILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQ 248
Query: 230 IRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEM 289
+ + A +++P L L L++ NPL + F M
Sbjct: 249 LARVPRRALEQVPGLKFLDLNK------------------------NPLQRVGPGDFANM 284
Query: 290 GGLQELWLNR-TQLRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHS 348
L+EL LN +L ++ A NL L L +T +PRLS + AF L +++ L L++
Sbjct: 285 LHLKELGLNNMEELVSIDKFALVNLPELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNN 344
Query: 349 NGLTALPDGLLRGLGKLRQVSLRRNRLR 376
N L+AL + L L++V L N +R
Sbjct: 345 NALSALHQQTVESLPNLQEVGLHGNPIR 372
Score = 105 bits (261), Expect = 1e-22
Identities = 106/394 (26%), Positives = 157/394 (39%), Gaps = 14/394 (3%)
Query: 125 EQLFLDHNALRGIDQNMFQKLVNLQELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTH 184
+ L L N++ +DQ+ L NL EL L+QN F L L L L N LT
Sbjct: 72 QTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTR 131
Query: 185 LPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNL 244
L A L+ L L+ N+L + + L L L + N +R+I F+ LPNL
Sbjct: 132 LEDHSFAGLASLQELYLNHNQLYRIAPRAFSGLSNLLRLHLNSNLLRAIDSRWFEMLPNL 191
Query: 245 SSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRT 304
L + N + + F NL L L L E+ + L+ L QL
Sbjct: 192 EILMIGGNKVDAILDMNFRPLANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLAR 251
Query: 305 LPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHS-NGLTALPDGLLRGLG 363
+P A + L++L + +P L + G F + L+ L L++ L ++ L L
Sbjct: 252 VPRRALEQVPGLKFLDLNKNP-LQRVGPGDFANMLHLKELGLNNMEELVSIDKFALVNLP 310
Query: 364 KLRQVSLRRN-RLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNS 422
+L ++ + N RL + F +L +E++ L++N L L +LP L EV L N
Sbjct: 311 ELTKLDITNNPRLSFIHPRAFHHLPQMETLMLNNNALSALHQQTVESLPNLQEVGLHGNP 370
Query: 423 WRCDCGLGPFLGWLRQHLGLVGGEEPPR--CAGPGAHAGLPLWALPGGD-----AECPGP 475
RCDC + W V EP CA P LP+ +P + P
Sbjct: 371 IRCDC----VIRWANATGTRVRFIEPQSTLCAEPPDLQRLPVREVPFREMTDHCLPLISP 426
Query: 476 RGPPPRPAADSSSEAPVHPALAPNSSEPWVWAQP 509
R PP S +H W P
Sbjct: 427 RSFPPSLQVASGESMVLHCRALAEPEPEIYWVTP 460
Score = 82.4 bits (202), Expect = 1e-15
Identities = 85/267 (31%), Positives = 109/267 (40%), Gaps = 30/267 (11%)
Query: 182 LTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHRNHIRSIAPGAFDRL 241
LT +P L A + LLL SN +V +D L L LTEL +N F L
Sbjct: 60 LTAVPPAL---PAGTQTLLLQSNSIVRVDQSELGYLANLTELDLSQNSFSDARDCDFHAL 116
Query: 242 PNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVLFGEMGGLQELWLNRTQ 301
P L SL L N L L HS F + LQEL+LN Q
Sbjct: 117 PQLLSLHLEENQLTRLED----HS--------------------FAGLASLQELYLNHNQ 152
Query: 302 LRTLPAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRG 361
L + AF LS L L + S L A+ F+ L L++L + N + A+ D R
Sbjct: 153 LYRIAPRAFSGLSNLLRLHLN-SNLLRAIDSRWFEMLPNLEILMIGGNKVDAILDMNFRP 211
Query: 362 LGKLRQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
L LR + L LR + L SLES+ NQL +P +P L + L N
Sbjct: 212 LANLRSLVLAGMNLREISDYALEGLQSLESLSFYDNQLARVPRRALEQVPGLKFLDLNKN 271
Query: 422 SWRCDCGLGPFLGWLR-QHLGLVGGEE 447
+ G G F L + LGL EE
Sbjct: 272 PLQ-RVGPGDFANMLHLKELGLNNMEE 297
Score = 42.0 bits (97), Expect = 0.001
Identities = 33/116 (28%), Positives = 48/116 (41%), Gaps = 7/116 (6%)
Query: 306 PAAAFRNLSRLRYLGVTLSPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKL 365
P +++R + + + L+ ALP G Q L L SN + + L L L
Sbjct: 43 PRSSYREATTVDCNDLFLTAVPPALPAGT-------QTLLLQSNSIVRVDQSELGYLANL 95
Query: 366 RQVSLRRNRLRALPRALFRNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHN 421
++ L +N F L L S+ L+ NQL L F L L E+ L HN
Sbjct: 96 TELDLSQNSFSDARDCDFHALPQLLSLHLEENQLTRLEDHSFAGLASLQELYLNHN 151
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.140 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,213,754
Number of Sequences: 37866
Number of extensions: 1259460
Number of successful extensions: 12143
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 275
Number of HSP's successfully gapped in prelim test: 276
Number of HSP's that attempted gapping in prelim test: 6741
Number of HSP's gapped (non-prelim): 3136
length of query: 560
length of database: 18,247,518
effective HSP length: 107
effective length of query: 453
effective length of database: 14,195,856
effective search space: 6430722768
effective search space used: 6430722768
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.