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Search of human proteins with 4757988
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4757988 WD repeat domain 39 [Homo sapiens]
(339 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4757988 WD repeat domain 39 [Homo sapiens] 733 0.0
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 124 1e-28
gi|213021190 transducin beta-like 1X isoform b [Homo sapiens] 123 3e-28
gi|213021188 transducin beta-like 1X isoform b [Homo sapiens] 123 3e-28
gi|213021186 transducin beta-like 1X isoform a [Homo sapiens] 123 3e-28
gi|5032159 transducin beta-like 1X isoform a [Homo sapiens] 123 3e-28
gi|19913367 transducin beta-like 1Y [Homo sapiens] 122 6e-28
gi|19913365 transducin beta-like 1Y [Homo sapiens] 122 6e-28
gi|15150805 transducin beta-like 1Y [Homo sapiens] 122 6e-28
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 108 7e-24
gi|210032390 SEC13 protein isoform 2 [Homo sapiens] 103 2e-22
gi|34335134 SEC13 protein isoform 1 [Homo sapiens] 103 2e-22
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 99 4e-21
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 99 7e-21
gi|16554629 WD repeat domain 5 [Homo sapiens] 98 9e-21
gi|16554627 WD repeat domain 5 [Homo sapiens] 98 9e-21
gi|26665869 WD repeat domain 51B [Homo sapiens] 97 2e-20
gi|32189425 WD repeat domain 69 [Homo sapiens] 96 6e-20
gi|19913369 transducin beta-like 3 [Homo sapiens] 95 8e-20
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 94 2e-19
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 94 2e-19
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 94 2e-19
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 94 2e-19
gi|113865883 WD repeat domain 38 [Homo sapiens] 92 5e-19
gi|23199987 WD repeat domain 5B [Homo sapiens] 92 7e-19
gi|169403944 WD repeat domain 26 isoform b [Homo sapiens] 87 3e-17
gi|55743153 WD repeat domain 26 isoform a [Homo sapiens] 87 3e-17
gi|21071067 TBP-associated factor 5 [Homo sapiens] 86 6e-17
gi|5803221 WD repeat-containing protein 3 [Homo sapiens] 86 6e-17
gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens] 86 6e-17
>gi|4757988 WD repeat domain 39 [Homo sapiens]
Length = 339
Score = 733 bits (1891), Expect = 0.0
Identities = 339/339 (100%), Positives = 339/339 (100%)
Query: 1 MKDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGH 60
MKDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGH
Sbjct: 1 MKDSLVLLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGH 60
Query: 61 QRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLL 120
QRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLL
Sbjct: 61 QRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLL 120
Query: 121 ATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREE 180
ATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREE
Sbjct: 121 ATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREE 180
Query: 181 EDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS 240
EDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS
Sbjct: 181 EDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS 240
Query: 241 WKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQ 300
WKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQ
Sbjct: 241 WKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQ 300
Query: 301 AHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEGL 339
AHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEGL
Sbjct: 301 AHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPEGL 339
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 124 bits (311), Expect = 1e-28
Identities = 83/259 (32%), Positives = 125/259 (48%), Gaps = 59/259 (22%)
Query: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
VP++ D L WN GTLLA+ D RIW +G+ S L + H+ + + W+
Sbjct: 222 VPSNKDVTS--LDWNSEGTLLATGSYDGFARIWTKDGN---LASTLGQ-HKGPIFALKWN 275
Query: 71 PCGNYLASASFDATTCIW-----------------------KKNQDDFECVT-------- 99
GN++ SA D TT IW + N C T
Sbjct: 276 KKGNFILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQSNNTFASCSTDMCIHVCK 335
Query: 100 --------TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
T +GH NEV ++ W P+GNLLA+CS D ++ +W + +++ CV L +H +
Sbjct: 336 LGQDRPIKTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIWSMKQDN---CVHDLQAHNK 392
Query: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
++ + W P + +LASAS+D TV+L+ + D +C TL H+ V+S+AF
Sbjct: 393 EIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLW--DVDRGICIHTLTKHQEPVYSVAF 450
Query: 203 DPSGQRLASCSDDRTVRIW 221
P G+ LAS S D+ V IW
Sbjct: 451 SPDGRYLASGSFDKCVHIW 469
Score = 108 bits (269), Expect = 9e-24
Identities = 95/340 (27%), Positives = 142/340 (41%), Gaps = 57/340 (16%)
Query: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEGHQ-----RTV 64
+S + AWNP LLAS GD RIW +S + + + EG Q + V
Sbjct: 169 ESEVFICAWNPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHCIREGGQDVPSNKDV 228
Query: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
+ W+ G LA+ S+D IW K D +TL H+ + ++ W GN + +
Sbjct: 229 TSLDWNSEGTLLATGSYDGFARIWTK---DGNLASTLGQHKGPIFALKWNKKGNFILSAG 285
Query: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
DK+ +W+ E H+ V W S AS S D + + + +D
Sbjct: 286 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-SNNTFASCSTDMCIHVCKLGQDRP 341
Query: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
+ T +GH + V ++ +DP+G LASCSDD T++IW S C+
Sbjct: 342 I--KTFQGHTNEVNAIKWDPTGNLLASCSDDMTLKIW---------------SMKQDNCV 384
Query: 245 CTLSGFHSRTIYDIAWCQLTG----------ALATACGDDAIRVFQEDPNSDPQQPTFSL 294
L H++ IY I W TG LA+A D +R++ D +
Sbjct: 385 HDLQA-HNKEIYTIKWSP-TGPGTNNPNANLMLASASFDSTVRLWDVDR---------GI 433
Query: 295 TAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
H H + V VA++P + LAS S D V W Q
Sbjct: 434 CIHTLTKHQEPVYSVAFSP-DGRYLASGSFDKCVHIWNTQ 472
Score = 32.0 bits (71), Expect = 0.81
Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+A++P G LAS D+ + IW T+ + + + G + +V W+ G+ + +++
Sbjct: 448 VAFSPDGRYLASGSFDKCVHIWNTQTGALVHSYRGTGG----IFEVCWNAAGDKVGASAS 503
Query: 82 DATTCI 87
D + C+
Sbjct: 504 DGSVCV 509
>gi|213021190 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 123 bits (308), Expect = 3e-28
Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)
Query: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
VP++ D L WN GTLLA+ D RIW +G+ S L + H+ + + W+
Sbjct: 234 VPSNKDVTS--LDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQ-HKGPIFALKWN 287
Query: 71 PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97
GNY+ SA D TT IW K Q F
Sbjct: 288 RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCR 347
Query: 98 ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
V T +GH NEV ++ W PSG LLA+CS D ++ +W + +E C+ L +H +
Sbjct: 348 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNK 404
Query: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
++ + W P S +LASAS+D TV+L+ E VC TL H+ V+S+AF
Sbjct: 405 EIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAF 462
Query: 203 DPSGQRLASCSDDRTVRIW 221
P G+ LAS S D+ V IW
Sbjct: 463 SPDGKYLASGSFDKCVHIW 481
Score = 103 bits (256), Expect = 3e-22
Identities = 95/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64
+S + AWNP LLAS GD RIW +S + + + EG + V
Sbjct: 181 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 240
Query: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
+ W+ G LA+ S+D IW +D +TL H+ + ++ W GN + +
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 297
Query: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
DK+ +W+ E H+ V W + AS S D + + R D
Sbjct: 298 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRP 353
Query: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
V T +GH + V ++ +DPSG LASCSDD T++IW +Q V CI
Sbjct: 354 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM-----KQEV----------CI 396
Query: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295
L H++ IY I W A LA+A D +R++ + +
Sbjct: 397 HDLQA-HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER---------GVC 446
Query: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
H H + V VA++P + LAS S D V W Q
Sbjct: 447 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQ 484
Score = 86.7 bits (213), Expect = 3e-17
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 41/248 (16%)
Query: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149
T L GHE+EV AW P +LLA+ S D + +W ++E ++ H
Sbjct: 175 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234
Query: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
+DV + W+ + LLA+ SYD +++ E D +TL H+ +++L ++ G
Sbjct: 235 PSNKDVTSLDWNTNGTLLATGSYDGFARIWTE---DGNLASTLGQHKGPIFALKWNRKGN 291
Query: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267
+ S D+T IW + +Q FHS D+ W Q
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNTTF 334
Query: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327
A+ D I V + D TF Q H+ +VN + W+P LLASCSDD
Sbjct: 335 ASCSTDMCIHVCR--LGCDRPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 384
Query: 328 VAFWKYQR 335
+ W ++
Sbjct: 385 LKIWSMKQ 392
Score = 77.4 bits (189), Expect = 2e-14
Identities = 52/199 (26%), Positives = 89/199 (44%), Gaps = 20/199 (10%)
Query: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
T ASC D I + D + +GH V + W P G LAS S D T IW
Sbjct: 332 TTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388
Query: 89 KKNQDDFECVTTLEGHENEVKSVAWAPSGN---------LLATCSRDKSVWVWEVDEEDE 139
Q+ C+ L+ H E+ ++ W+P+G +LA+ S D +V +W+++
Sbjct: 389 SMKQE--VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG-- 444
Query: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
C L H + V V + P + LAS S+D V ++ + + V G ++
Sbjct: 445 -VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG---GIFE 500
Query: 200 LAFDPSGQRLASCSDDRTV 218
+ ++ G ++ + + D +V
Sbjct: 501 VCWNARGDKVGASASDGSV 519
Score = 31.6 bits (70), Expect = 1.1
Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+A++P G LAS D+ + IW T+ + + + G + +V W+ G+ + +++
Sbjct: 460 VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG----IFEVCWNARGDKVGASAS 515
Query: 82 DATTCI 87
D + C+
Sbjct: 516 DGSVCV 521
>gi|213021188 transducin beta-like 1X isoform b [Homo sapiens]
Length = 526
Score = 123 bits (308), Expect = 3e-28
Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)
Query: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
VP++ D L WN GTLLA+ D RIW +G+ S L + H+ + + W+
Sbjct: 234 VPSNKDVTS--LDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQ-HKGPIFALKWN 287
Query: 71 PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97
GNY+ SA D TT IW K Q F
Sbjct: 288 RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCR 347
Query: 98 ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
V T +GH NEV ++ W PSG LLA+CS D ++ +W + +E C+ L +H +
Sbjct: 348 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNK 404
Query: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
++ + W P S +LASAS+D TV+L+ E VC TL H+ V+S+AF
Sbjct: 405 EIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAF 462
Query: 203 DPSGQRLASCSDDRTVRIW 221
P G+ LAS S D+ V IW
Sbjct: 463 SPDGKYLASGSFDKCVHIW 481
Score = 103 bits (256), Expect = 3e-22
Identities = 95/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64
+S + AWNP LLAS GD RIW +S + + + EG + V
Sbjct: 181 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 240
Query: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
+ W+ G LA+ S+D IW +D +TL H+ + ++ W GN + +
Sbjct: 241 TSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 297
Query: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
DK+ +W+ E H+ V W + AS S D + + R D
Sbjct: 298 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRP 353
Query: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
V T +GH + V ++ +DPSG LASCSDD T++IW +Q V CI
Sbjct: 354 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM-----KQEV----------CI 396
Query: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295
L H++ IY I W A LA+A D +R++ + +
Sbjct: 397 HDLQA-HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER---------GVC 446
Query: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
H H + V VA++P + LAS S D V W Q
Sbjct: 447 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQ 484
Score = 86.7 bits (213), Expect = 3e-17
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 41/248 (16%)
Query: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149
T L GHE+EV AW P +LLA+ S D + +W ++E ++ H
Sbjct: 175 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 234
Query: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
+DV + W+ + LLA+ SYD +++ E D +TL H+ +++L ++ G
Sbjct: 235 PSNKDVTSLDWNTNGTLLATGSYDGFARIWTE---DGNLASTLGQHKGPIFALKWNRKGN 291
Query: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267
+ S D+T IW + +Q FHS D+ W Q
Sbjct: 292 YILSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNTTF 334
Query: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327
A+ D I V + D TF Q H+ +VN + W+P LLASCSDD
Sbjct: 335 ASCSTDMCIHVCR--LGCDRPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 384
Query: 328 VAFWKYQR 335
+ W ++
Sbjct: 385 LKIWSMKQ 392
Score = 77.4 bits (189), Expect = 2e-14
Identities = 52/199 (26%), Positives = 89/199 (44%), Gaps = 20/199 (10%)
Query: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
T ASC D I + D + +GH V + W P G LAS S D T IW
Sbjct: 332 TTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 388
Query: 89 KKNQDDFECVTTLEGHENEVKSVAWAPSGN---------LLATCSRDKSVWVWEVDEEDE 139
Q+ C+ L+ H E+ ++ W+P+G +LA+ S D +V +W+++
Sbjct: 389 SMKQE--VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG-- 444
Query: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
C L H + V V + P + LAS S+D V ++ + + V G ++
Sbjct: 445 -VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG---GIFE 500
Query: 200 LAFDPSGQRLASCSDDRTV 218
+ ++ G ++ + + D +V
Sbjct: 501 VCWNARGDKVGASASDGSV 519
Score = 31.6 bits (70), Expect = 1.1
Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+A++P G LAS D+ + IW T+ + + + G + +V W+ G+ + +++
Sbjct: 460 VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG----IFEVCWNARGDKVGASAS 515
Query: 82 DATTCI 87
D + C+
Sbjct: 516 DGSVCV 521
>gi|213021186 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 123 bits (308), Expect = 3e-28
Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)
Query: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
VP++ D L WN GTLLA+ D RIW +G+ S L + H+ + + W+
Sbjct: 285 VPSNKDVTS--LDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQ-HKGPIFALKWN 338
Query: 71 PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97
GNY+ SA D TT IW K Q F
Sbjct: 339 RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCR 398
Query: 98 ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
V T +GH NEV ++ W PSG LLA+CS D ++ +W + +E C+ L +H +
Sbjct: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNK 455
Query: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
++ + W P S +LASAS+D TV+L+ E VC TL H+ V+S+AF
Sbjct: 456 EIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAF 513
Query: 203 DPSGQRLASCSDDRTVRIW 221
P G+ LAS S D+ V IW
Sbjct: 514 SPDGKYLASGSFDKCVHIW 532
Score = 103 bits (256), Expect = 3e-22
Identities = 95/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64
+S + AWNP LLAS GD RIW +S + + + EG + V
Sbjct: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
Query: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
+ W+ G LA+ S+D IW +D +TL H+ + ++ W GN + +
Sbjct: 292 TSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 348
Query: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
DK+ +W+ E H+ V W + AS S D + + R D
Sbjct: 349 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRP 404
Query: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
V T +GH + V ++ +DPSG LASCSDD T++IW +Q V CI
Sbjct: 405 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM-----KQEV----------CI 447
Query: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295
L H++ IY I W A LA+A D +R++ + +
Sbjct: 448 HDLQA-HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER---------GVC 497
Query: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
H H + V VA++P + LAS S D V W Q
Sbjct: 498 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQ 535
Score = 86.7 bits (213), Expect = 3e-17
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 41/248 (16%)
Query: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149
T L GHE+EV AW P +LLA+ S D + +W ++E ++ H
Sbjct: 226 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285
Query: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
+DV + W+ + LLA+ SYD +++ E D +TL H+ +++L ++ G
Sbjct: 286 PSNKDVTSLDWNTNGTLLATGSYDGFARIWTE---DGNLASTLGQHKGPIFALKWNRKGN 342
Query: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267
+ S D+T IW + +Q FHS D+ W Q
Sbjct: 343 YILSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNTTF 385
Query: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327
A+ D I V + D TF Q H+ +VN + W+P LLASCSDD
Sbjct: 386 ASCSTDMCIHVCR--LGCDRPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 435
Query: 328 VAFWKYQR 335
+ W ++
Sbjct: 436 LKIWSMKQ 443
Score = 77.4 bits (189), Expect = 2e-14
Identities = 52/199 (26%), Positives = 89/199 (44%), Gaps = 20/199 (10%)
Query: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
T ASC D I + D + +GH V + W P G LAS S D T IW
Sbjct: 383 TTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
Query: 89 KKNQDDFECVTTLEGHENEVKSVAWAPSGN---------LLATCSRDKSVWVWEVDEEDE 139
Q+ C+ L+ H E+ ++ W+P+G +LA+ S D +V +W+++
Sbjct: 440 SMKQE--VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG-- 495
Query: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
C L H + V V + P + LAS S+D V ++ + + V G ++
Sbjct: 496 -VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG---GIFE 551
Query: 200 LAFDPSGQRLASCSDDRTV 218
+ ++ G ++ + + D +V
Sbjct: 552 VCWNARGDKVGASASDGSV 570
Score = 31.6 bits (70), Expect = 1.1
Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+A++P G LAS D+ + IW T+ + + + G + +V W+ G+ + +++
Sbjct: 511 VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG----IFEVCWNARGDKVGASAS 566
Query: 82 DATTCI 87
D + C+
Sbjct: 567 DGSVCV 572
>gi|5032159 transducin beta-like 1X isoform a [Homo sapiens]
Length = 577
Score = 123 bits (308), Expect = 3e-28
Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)
Query: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
VP++ D L WN GTLLA+ D RIW +G+ S L + H+ + + W+
Sbjct: 285 VPSNKDVTS--LDWNTNGTLLATGSYDGFARIWTEDGN---LASTLGQ-HKGPIFALKWN 338
Query: 71 PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97
GNY+ SA D TT IW K Q F
Sbjct: 339 RKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCR 398
Query: 98 ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
V T +GH NEV ++ W PSG LLA+CS D ++ +W + +E C+ L +H +
Sbjct: 399 LGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQE---VCIHDLQAHNK 455
Query: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
++ + W P S +LASAS+D TV+L+ E VC TL H+ V+S+AF
Sbjct: 456 EIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG--VCTHTLTKHQEPVYSVAF 513
Query: 203 DPSGQRLASCSDDRTVRIW 221
P G+ LAS S D+ V IW
Sbjct: 514 SPDGKYLASGSFDKCVHIW 532
Score = 103 bits (256), Expect = 3e-22
Identities = 95/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64
+S + AWNP LLAS GD RIW +S + + + EG + V
Sbjct: 232 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 291
Query: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
+ W+ G LA+ S+D IW +D +TL H+ + ++ W GN + +
Sbjct: 292 TSLDWNTNGTLLATGSYDGFARIW---TEDGNLASTLGQHKGPIFALKWNRKGNYILSAG 348
Query: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
DK+ +W+ E H+ V W + AS S D + + R D
Sbjct: 349 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNTTFASCSTDMCIHVCRLGCDRP 404
Query: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
V T +GH + V ++ +DPSG LASCSDD T++IW +Q V CI
Sbjct: 405 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSM-----KQEV----------CI 447
Query: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295
L H++ IY I W A LA+A D +R++ + +
Sbjct: 448 HDLQA-HNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIER---------GVC 497
Query: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
H H + V VA++P + LAS S D V W Q
Sbjct: 498 THTLTKHQEPVYSVAFSP-DGKYLASGSFDKCVHIWNTQ 535
Score = 86.7 bits (213), Expect = 3e-17
Identities = 68/248 (27%), Positives = 106/248 (42%), Gaps = 41/248 (16%)
Query: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149
T L GHE+EV AW P +LLA+ S D + +W ++E ++ H
Sbjct: 226 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 285
Query: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
+DV + W+ + LLA+ SYD +++ E D +TL H+ +++L ++ G
Sbjct: 286 PSNKDVTSLDWNTNGTLLATGSYDGFARIWTE---DGNLASTLGQHKGPIFALKWNRKGN 342
Query: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267
+ S D+T IW + +Q FHS D+ W Q
Sbjct: 343 YILSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNTTF 385
Query: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327
A+ D I V + D TF Q H+ +VN + W+P LLASCSDD
Sbjct: 386 ASCSTDMCIHVCR--LGCDRPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 435
Query: 328 VAFWKYQR 335
+ W ++
Sbjct: 436 LKIWSMKQ 443
Score = 77.4 bits (189), Expect = 2e-14
Identities = 52/199 (26%), Positives = 89/199 (44%), Gaps = 20/199 (10%)
Query: 29 TLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
T ASC D I + D + +GH V + W P G LAS S D T IW
Sbjct: 383 TTFASCSTDMCIHVCRLGCDRPV---KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW 439
Query: 89 KKNQDDFECVTTLEGHENEVKSVAWAPSGN---------LLATCSRDKSVWVWEVDEEDE 139
Q+ C+ L+ H E+ ++ W+P+G +LA+ S D +V +W+++
Sbjct: 440 SMKQE--VCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERG-- 495
Query: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWS 199
C L H + V V + P + LAS S+D V ++ + + V G ++
Sbjct: 496 -VCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTG---GIFE 551
Query: 200 LAFDPSGQRLASCSDDRTV 218
+ ++ G ++ + + D +V
Sbjct: 552 VCWNARGDKVGASASDGSV 570
Score = 31.6 bits (70), Expect = 1.1
Identities = 16/66 (24%), Positives = 35/66 (53%), Gaps = 4/66 (6%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+A++P G LAS D+ + IW T+ + + + G + +V W+ G+ + +++
Sbjct: 511 VAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGG----IFEVCWNARGDKVGASAS 566
Query: 82 DATTCI 87
D + C+
Sbjct: 567 DGSVCV 572
>gi|19913367 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 122 bits (305), Expect = 6e-28
Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)
Query: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
VP++ D L WN GTLLA D RIW G+ S L + H+ + + W+
Sbjct: 232 VPSNKDVTS--LDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQ-HKGPIFALKWN 285
Query: 71 PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97
GNY+ SA D TT IW K Q F
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCR 345
Query: 98 ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
V T +GH NEV ++ W PSG LLA+CS D ++ +W + ++ CV L +H++
Sbjct: 346 LGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD---ACVHDLQAHSK 402
Query: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
++ + W P S +LASAS+D TV+L+ E+ VC TL H+ V+S+AF
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAF 460
Query: 203 DPSGQRLASCSDDRTVRIW 221
P G+ LAS S D+ V IW
Sbjct: 461 SPDGKYLASGSFDKYVHIW 479
Score = 105 bits (262), Expect = 6e-23
Identities = 96/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64
+S + AWNP LLAS GD RIW +S + + + EG + V
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
Query: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
+ W+ G LA S+D IW +N + +TL H+ + ++ W GN + +
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALKWNKKGNYVLSAG 295
Query: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
DK+ +W+ E H+ V W + AS S D + + R D
Sbjct: 296 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHP 351
Query: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
V T +GH + V ++ +DPSG LASCSDD T++IW S C+
Sbjct: 352 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW---------------SMKQDACV 394
Query: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295
L HS+ IY I W A LA+A D +R++ D +Q +
Sbjct: 395 HDLQA-HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW------DVEQ---GVC 444
Query: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
H H + V VA++P + LAS S D V W Q
Sbjct: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQ 482
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/248 (27%), Positives = 104/248 (41%), Gaps = 41/248 (16%)
Query: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149
T L GHE+EV AW P +LLA+ S D + +W ++E ++ H
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
+DV + W+ LLA SYD +++ E + +TL H+ +++L ++ G
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALKWNKKGN 289
Query: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267
+ S D+T IW + +Q FHS D+ W Q
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNMTF 332
Query: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327
A+ D I V + D TF Q H+ +VN + W+P LLASCSDD
Sbjct: 333 ASCSTDMCIHVCR--LGCDHPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 382
Query: 328 VAFWKYQR 335
+ W ++
Sbjct: 383 LKIWSMKQ 390
Score = 79.0 bits (193), Expect = 6e-15
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 21/172 (12%)
Query: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG 117
+GH V + W P G LAS S D T IW QD CV L+ H E+ ++ W+P+G
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD--ACVHDLQAHSKEIYTIKWSPTG 413
Query: 118 N---------LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASA 168
+LA+ S D +V +W+V++ C L H + V V + P + LAS
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQG---VCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 169 SYDDTVKLYREEEDDWVCCATLEGHEST--VWSLAFDPSGQRLASCSDDRTV 218
S+D V ++ + V ++ T ++ + ++ G ++ + + D +V
Sbjct: 471 SFDKYVHIWNTQSGSLV-----HSYQGTGGIFEVCWNARGDKVGASASDGSV 517
Score = 34.3 bits (77), Expect = 0.16
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 8/68 (11%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWSPCGNYLASA 79
+A++P G LAS D+ + IW T+ S L +Q T + +V W+ G+ + ++
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGS------LVHSYQGTGGIFEVCWNARGDKVGAS 511
Query: 80 SFDATTCI 87
+ D + C+
Sbjct: 512 ASDGSVCV 519
>gi|19913365 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 122 bits (305), Expect = 6e-28
Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)
Query: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
VP++ D L WN GTLLA D RIW G+ S L + H+ + + W+
Sbjct: 232 VPSNKDVTS--LDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQ-HKGPIFALKWN 285
Query: 71 PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97
GNY+ SA D TT IW K Q F
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCR 345
Query: 98 ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
V T +GH NEV ++ W PSG LLA+CS D ++ +W + ++ CV L +H++
Sbjct: 346 LGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD---ACVHDLQAHSK 402
Query: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
++ + W P S +LASAS+D TV+L+ E+ VC TL H+ V+S+AF
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAF 460
Query: 203 DPSGQRLASCSDDRTVRIW 221
P G+ LAS S D+ V IW
Sbjct: 461 SPDGKYLASGSFDKYVHIW 479
Score = 105 bits (262), Expect = 6e-23
Identities = 96/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64
+S + AWNP LLAS GD RIW +S + + + EG + V
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
Query: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
+ W+ G LA S+D IW +N + +TL H+ + ++ W GN + +
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALKWNKKGNYVLSAG 295
Query: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
DK+ +W+ E H+ V W + AS S D + + R D
Sbjct: 296 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHP 351
Query: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
V T +GH + V ++ +DPSG LASCSDD T++IW S C+
Sbjct: 352 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW---------------SMKQDACV 394
Query: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295
L HS+ IY I W A LA+A D +R++ D +Q +
Sbjct: 395 HDLQA-HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW------DVEQ---GVC 444
Query: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
H H + V VA++P + LAS S D V W Q
Sbjct: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQ 482
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/248 (27%), Positives = 104/248 (41%), Gaps = 41/248 (16%)
Query: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149
T L GHE+EV AW P +LLA+ S D + +W ++E ++ H
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
+DV + W+ LLA SYD +++ E + +TL H+ +++L ++ G
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALKWNKKGN 289
Query: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267
+ S D+T IW + +Q FHS D+ W Q
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNMTF 332
Query: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327
A+ D I V + D TF Q H+ +VN + W+P LLASCSDD
Sbjct: 333 ASCSTDMCIHVCR--LGCDHPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 382
Query: 328 VAFWKYQR 335
+ W ++
Sbjct: 383 LKIWSMKQ 390
Score = 79.0 bits (193), Expect = 6e-15
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 21/172 (12%)
Query: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG 117
+GH V + W P G LAS S D T IW QD CV L+ H E+ ++ W+P+G
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD--ACVHDLQAHSKEIYTIKWSPTG 413
Query: 118 N---------LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASA 168
+LA+ S D +V +W+V++ C L H + V V + P + LAS
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQG---VCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 169 SYDDTVKLYREEEDDWVCCATLEGHEST--VWSLAFDPSGQRLASCSDDRTV 218
S+D V ++ + V ++ T ++ + ++ G ++ + + D +V
Sbjct: 471 SFDKYVHIWNTQSGSLV-----HSYQGTGGIFEVCWNARGDKVGASASDGSV 517
Score = 34.3 bits (77), Expect = 0.16
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 8/68 (11%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWSPCGNYLASA 79
+A++P G LAS D+ + IW T+ S L +Q T + +V W+ G+ + ++
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGS------LVHSYQGTGGIFEVCWNARGDKVGAS 511
Query: 80 SFDATTCI 87
+ D + C+
Sbjct: 512 ASDGSVCV 519
>gi|15150805 transducin beta-like 1Y [Homo sapiens]
Length = 522
Score = 122 bits (305), Expect = 6e-28
Identities = 87/259 (33%), Positives = 122/259 (47%), Gaps = 59/259 (22%)
Query: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
VP++ D L WN GTLLA D RIW G+ S L + H+ + + W+
Sbjct: 232 VPSNKDVTS--LDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQ-HKGPIFALKWN 285
Query: 71 PCGNYLASASFDATTCIWK------KNQDDFEC--------------------------- 97
GNY+ SA D TT IW K Q F
Sbjct: 286 KKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNMTFASCSTDMCIHVCR 345
Query: 98 ------VTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQ 151
V T +GH NEV ++ W PSG LLA+CS D ++ +W + ++ CV L +H++
Sbjct: 346 LGCDHPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD---ACVHDLQAHSK 402
Query: 152 DVKHVVWHP---------SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
++ + W P S +LASAS+D TV+L+ E+ VC TL H+ V+S+AF
Sbjct: 403 EIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLWDVEQG--VCTHTLMKHQEPVYSVAF 460
Query: 203 DPSGQRLASCSDDRTVRIW 221
P G+ LAS S D+ V IW
Sbjct: 461 SPDGKYLASGSFDKYVHIW 479
Score = 105 bits (262), Expect = 6e-23
Identities = 96/339 (28%), Positives = 141/339 (41%), Gaps = 55/339 (16%)
Query: 16 DSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDS------WICKSVLSEG-----HQRTV 64
+S + AWNP LLAS GD RIW +S + + + EG + V
Sbjct: 179 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDV 238
Query: 65 RKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
+ W+ G LA S+D IW +N + +TL H+ + ++ W GN + +
Sbjct: 239 TSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALKWNKKGNYVLSAG 295
Query: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDW 184
DK+ +W+ E H+ V W + AS S D + + R D
Sbjct: 296 VDKTTIIWDAHTG---EAKQQFPFHSAPALDVDWQ-NNMTFASCSTDMCIHVCRLGCDHP 351
Query: 185 VCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCI 244
V T +GH + V ++ +DPSG LASCSDD T++IW S C+
Sbjct: 352 V--KTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIW---------------SMKQDACV 394
Query: 245 CTLSGFHSRTIYDIAWCQLTGA---------LATACGDDAIRVFQEDPNSDPQQPTFSLT 295
L HS+ IY I W A LA+A D +R++ D +Q +
Sbjct: 395 HDLQA-HSKEIYTIKWSPTGPATSNPNSSIMLASASFDSTVRLW------DVEQ---GVC 444
Query: 296 AHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQ 334
H H + V VA++P + LAS S D V W Q
Sbjct: 445 THTLMKHQEPVYSVAFSP-DGKYLASGSFDKYVHIWNTQ 482
Score = 84.3 bits (207), Expect = 1e-16
Identities = 67/248 (27%), Positives = 104/248 (41%), Gaps = 41/248 (16%)
Query: 99 TTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH--------- 149
T L GHE+EV AW P +LLA+ S D + +W ++E ++ H
Sbjct: 173 TVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDV 232
Query: 150 --TQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQ 207
+DV + W+ LLA SYD +++ E + +TL H+ +++L ++ G
Sbjct: 233 PSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGN---LASTLGQHKGPIFALKWNKKGN 289
Query: 208 RLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL 267
+ S D+T IW + +Q FHS D+ W Q
Sbjct: 290 YVLSAGVDKTTIIWDAHTGEAKQQFP----------------FHSAPALDVDW-QNNMTF 332
Query: 268 ATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGE 327
A+ D I V + D TF Q H+ +VN + W+P LLASCSDD
Sbjct: 333 ASCSTDMCIHVCR--LGCDHPVKTF-------QGHTNEVNAIKWDPSGM-LLASCSDDMT 382
Query: 328 VAFWKYQR 335
+ W ++
Sbjct: 383 LKIWSMKQ 390
Score = 79.0 bits (193), Expect = 6e-15
Identities = 48/172 (27%), Positives = 82/172 (47%), Gaps = 21/172 (12%)
Query: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG 117
+GH V + W P G LAS S D T IW QD CV L+ H E+ ++ W+P+G
Sbjct: 356 QGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQD--ACVHDLQAHSKEIYTIKWSPTG 413
Query: 118 N---------LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASA 168
+LA+ S D +V +W+V++ C L H + V V + P + LAS
Sbjct: 414 PATSNPNSSIMLASASFDSTVRLWDVEQG---VCTHTLMKHQEPVYSVAFSPDGKYLASG 470
Query: 169 SYDDTVKLYREEEDDWVCCATLEGHEST--VWSLAFDPSGQRLASCSDDRTV 218
S+D V ++ + V ++ T ++ + ++ G ++ + + D +V
Sbjct: 471 SFDKYVHIWNTQSGSLV-----HSYQGTGGIFEVCWNARGDKVGASASDGSV 517
Score = 34.3 bits (77), Expect = 0.16
Identities = 19/68 (27%), Positives = 36/68 (52%), Gaps = 8/68 (11%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRT--VRKVAWSPCGNYLASA 79
+A++P G LAS D+ + IW T+ S L +Q T + +V W+ G+ + ++
Sbjct: 458 VAFSPDGKYLASGSFDKYVHIWNTQSGS------LVHSYQGTGGIFEVCWNARGDKVGAS 511
Query: 80 SFDATTCI 87
+ D + C+
Sbjct: 512 ASDGSVCV 519
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 108 bits (270), Expect = 7e-24
Identities = 69/220 (31%), Positives = 105/220 (47%), Gaps = 30/220 (13%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
++++ +G LLASC D I++W +G I GH V VA P G+++ SAS
Sbjct: 156 ISFDHSGKLLASCSADMTIKLWDFQGFECIRTM---HGHDHNVSSVAIMPNGDHIVSASR 212
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D T +W+ CV T GH V+ V G L+A+CS D++V VW V + E
Sbjct: 213 DKTIKMWEVQTG--YCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATK---E 267
Query: 142 CVSVLNSHTQDVKHVVWHPSQE--------------------LLASASYDDTVKLYREEE 181
C + L H V+ + W P L S S D T+K++ +
Sbjct: 268 CKAELREHEHVVECISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW--DV 325
Query: 182 DDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
+C TL GH++ V + F G+ + SC+DD+T+R+W
Sbjct: 326 STGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVW 365
Score = 106 bits (264), Expect = 3e-23
Identities = 57/163 (34%), Positives = 91/163 (55%), Gaps = 7/163 (4%)
Query: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
GH+ V +V + P + + SAS DAT +W DFE TL+GH + V+ +++ SG
Sbjct: 106 GHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGK 163
Query: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
LLA+CS D ++ +W+ +EC+ ++ H +V V P+ + + SAS D T+K++
Sbjct: 164 LLASCSADMTIKLWDF---QGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMW- 219
Query: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
E C T GH V + + G +ASCS+D+TVR+W
Sbjct: 220 -EVQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVW 261
Score = 91.3 bits (225), Expect = 1e-18
Identities = 62/218 (28%), Positives = 104/218 (47%), Gaps = 30/218 (13%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
++P +++ S D I++W E + +GH +V+ +++ G LAS S D
Sbjct: 116 FHPVFSVMVSASEDATIKVWDYETGDF---ERTLKGHTDSVQDISFDHSGKLLASCSADM 172
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
T +W + FEC+ T+ GH++ V SVA P+G+ + + SRDK++ +WEV CV
Sbjct: 173 TIKLW--DFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWEVQTG---YCV 227
Query: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFD 203
H + V+ V + L+AS S D TV+++ + C A L HE V +++
Sbjct: 228 KTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKE--CKAELREHEHVVECISWA 285
Query: 204 PS--------------------GQRLASCSDDRTVRIW 221
P G L S S D+T+++W
Sbjct: 286 PESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323
Score = 80.5 bits (197), Expect = 2e-15
Identities = 50/173 (28%), Positives = 82/173 (47%), Gaps = 28/173 (16%)
Query: 25 NPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY--------- 75
N GTL+ASC D+ +R+W CK+ L E H+ V ++W+P +Y
Sbjct: 243 NQDGTLIASCSNDQTVRVWVVATKE--CKAELRE-HEHVVECISWAPESSYSSISEATGS 299
Query: 76 -----------LASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCS 124
L S S D T +W + C+ TL GH+N V+ V + G + +C+
Sbjct: 300 ETKKSGKPGPFLLSGSRDKTIKMWDVSTG--MCLMTLVGHDNWVRGVLFHSGGKFILSCA 357
Query: 125 RDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
DK++ VW+ + C+ LN+H V + +H + + + S D TVK++
Sbjct: 358 DDKTLRVWDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVW 407
Score = 75.1 bits (183), Expect = 8e-14
Identities = 69/237 (29%), Positives = 107/237 (45%), Gaps = 43/237 (18%)
Query: 98 VTTLEGHENEVKS--VAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKH 155
V LE NE K + P G RD W+ E+ L+ H V
Sbjct: 65 VMELESKLNEAKEEFTSGGPLGQ-----KRDPKEWIPRPPEK------YALSGHRSPVTR 113
Query: 156 VVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDD 215
V++HP ++ SAS D T+K++ E D+ TL+GH +V ++FD SG+ LASCS D
Sbjct: 114 VIFHPVFSVMVSASEDATIKVWDYETGDFE--RTLKGHTDSVQDISFDHSGKLLASCSAD 171
Query: 216 RTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDA 275
T+++W + QG ++CI T+ G H + +A + +A D
Sbjct: 172 MTIKLW------DFQG---------FECIRTMHG-HDHNVSSVAIMPNGDHIVSASRDKT 215
Query: 276 IRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPG-LLASCSDDGEVAFW 331
I++++ + TF+ H + V V P + G L+ASCS+D V W
Sbjct: 216 IKMWEVQTGYCVK--TFT-------GHREWVRMV--RPNQDGTLIASCSNDQTVRVW 261
Score = 48.1 bits (113), Expect = 1e-05
Identities = 34/107 (31%), Positives = 53/107 (49%), Gaps = 7/107 (6%)
Query: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCI 87
G L S D+ I++W + +C L GH VR V + G ++ S + D T +
Sbjct: 308 GPFLLSGSRDKTIKMWDVS--TGMCLMTLV-GHDNWVRGVLFHSGGKFILSCADDKTLRV 364
Query: 88 WK-KNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
W KN+ C+ TL HE+ V S+ + + + T S D++V VWE
Sbjct: 365 WDYKNK---RCMKTLNAHEHFVTSLDFHKTAPYVVTGSVDQTVKVWE 408
>gi|210032390 SEC13 protein isoform 2 [Homo sapiens]
Length = 308
Score = 103 bits (258), Expect = 2e-22
Identities = 83/280 (29%), Positives = 126/280 (45%), Gaps = 39/280 (13%)
Query: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP--CGNYLASASFDATT 85
GT LA+C DR ++I+ I + L GH+ V +VAW+ GN LAS S+D
Sbjct: 11 GTRLATCSSDRSVKIFDVRNGGQILIADL-RGHEGPVWQVAWAHPMYGNILASCSYDRKV 69
Query: 86 CIWKKNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEEDEYECV 143
IW++ +E GH++ V SV WAP G +LA S D ++ + E ++E
Sbjct: 70 IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 129
Query: 144 SVLNSHTQDVKHVVW-----------HPSQE------LLASASYDDTVKLYREEED-DWV 185
+ N+HT V W HPS + AS D+ +KL++EEED W
Sbjct: 130 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWK 189
Query: 186 CCATLEGHESTVWSLAFDPS----GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSW 241
LE H V +A+ PS +ASCS D V IW C + +
Sbjct: 190 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW-----------TCDDASSNT 238
Query: 242 KCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281
L F+ ++ ++W LA + GD+ + +++E
Sbjct: 239 WSPKLLHKFND-VVWHVSWSITANILAVSGGDNKVTLWKE 277
Score = 64.7 bits (156), Expect = 1e-10
Identities = 67/233 (28%), Positives = 101/233 (43%), Gaps = 32/233 (13%)
Query: 117 GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVW-HPSQ-ELLASASYDDTV 174
G LATCS D+SV +++V + ++ L H V V W HP +LAS SYD V
Sbjct: 11 GTRLATCSSDRSVKIFDVRNGGQI-LIADLRGHEGPVWQVAWAHPMYGNILASCSYDRKV 69
Query: 175 KLYREEEDDWVCCATLEGHESTVWSLAFDPS--GQRLASCSDDRTVRI--------WRQY 224
++REE W GH+S+V S+ + P G LA S D + + W
Sbjct: 70 IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 129
Query: 225 LPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGAL---ATACGDDAIRVFQE 281
N + C+ SW + G ++ D Q + A+ D+ I++++E
Sbjct: 130 KINNAHTIGCNAV--SW-APAVVPG----SLIDHPSGQKPNYIKRFASGGCDNLIKLWKE 182
Query: 282 DPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK---EPGLLASCSDDGEVAFW 331
+ + ++ +AHS V VAW P +ASCS DG V W
Sbjct: 183 EEDGQWKEE------QKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW 229
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 10/124 (8%)
Query: 32 ASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC----GNYLASASFDATTCI 87
AS G D I++W E D + E H VR VAW+P + +AS S D I
Sbjct: 169 ASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 228
Query: 88 WKKNQDDFECVT----TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
W DD T L + V V+W+ + N+LA D V +W+ + ++ C+
Sbjct: 229 W--TCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 286
Query: 144 SVLN 147
S +N
Sbjct: 287 SDVN 290
Score = 50.4 bits (119), Expect = 2e-06
Identities = 37/133 (27%), Positives = 57/133 (42%), Gaps = 22/133 (16%)
Query: 203 DPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQ 262
D G RLA+CS DR+V+I+ G I L G H ++ +AW
Sbjct: 8 DYYGTRLATCSSDRSVKIFDVRNGGQI-------------LIADLRG-HEGPVWQVAWAH 53
Query: 263 -LTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLAS 321
+ G + +C D + + N ++ +H H H VN V W P + GL+ +
Sbjct: 54 PMYGNILASCSYDRKVIIWREENGTWEK------SHEHAGHDSSVNSVCWAPHDYGLILA 107
Query: 322 C-SDDGEVAFWKY 333
C S DG ++ Y
Sbjct: 108 CGSSDGAISLLTY 120
Score = 35.8 bits (81), Expect = 0.056
Identities = 13/41 (31%), Positives = 24/41 (58%), Gaps = 1/41 (2%)
Query: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGD-SWICKSVLSEG 59
W ++W+ +LA GGD ++ +W D W+C S +++G
Sbjct: 252 WHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 292
>gi|34335134 SEC13 protein isoform 1 [Homo sapiens]
Length = 322
Score = 103 bits (258), Expect = 2e-22
Identities = 83/280 (29%), Positives = 126/280 (45%), Gaps = 39/280 (13%)
Query: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSP--CGNYLASASFDATT 85
GT LA+C DR ++I+ I + L GH+ V +VAW+ GN LAS S+D
Sbjct: 25 GTRLATCSSDRSVKIFDVRNGGQILIADL-RGHEGPVWQVAWAHPMYGNILASCSYDRKV 83
Query: 86 CIWKKNQDDFECVTTLEGHENEVKSVAWAPS--GNLLATCSRDKSVWVWEVDEEDEYECV 143
IW++ +E GH++ V SV WAP G +LA S D ++ + E ++E
Sbjct: 84 IIWREENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGSSDGAISLLTYTGEGQWEVK 143
Query: 144 SVLNSHTQDVKHVVW-----------HPSQE------LLASASYDDTVKLYREEED-DWV 185
+ N+HT V W HPS + AS D+ +KL++EEED W
Sbjct: 144 KINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFASGGCDNLIKLWKEEEDGQWK 203
Query: 186 CCATLEGHESTVWSLAFDPS----GQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSW 241
LE H V +A+ PS +ASCS D V IW C + +
Sbjct: 204 EEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFIW-----------TCDDASSNT 252
Query: 242 KCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281
L F+ ++ ++W LA + GD+ + +++E
Sbjct: 253 WSPKLLHKFND-VVWHVSWSITANILAVSGGDNKVTLWKE 291
Score = 69.7 bits (169), Expect = 4e-12
Identities = 82/310 (26%), Positives = 116/310 (37%), Gaps = 56/310 (18%)
Query: 54 SVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAW 113
+ + H+ + G LA+ S D + I+ + L GHE V VAW
Sbjct: 6 NTVDTSHEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQILIADLRGHEGPVWQVAW 65
Query: 114 APS--GNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE--LLASAS 169
A GN+LA+CS D+ V +W +E +E H V V W P +LA S
Sbjct: 66 AHPMYGNILASCSYDRKVIIWR-EENGTWEKSHEHAGHDSSVNSVCWAPHDYGLILACGS 124
Query: 170 YDDTVKLYR-EEEDDW----VCCATLEGHESTVW-------SLAFDPSGQ------RLAS 211
D + L E W + A G + W SL PSGQ R AS
Sbjct: 125 SDGAISLLTYTGEGQWEVKKINNAHTIGCNAVSWAPAVVPGSLIDHPSGQKPNYIKRFAS 184
Query: 212 CSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTG---ALA 268
D +++W++ D WK L HS + D+AW G +
Sbjct: 185 GGCDNLIKLWKE------------EEDGQWKEEQKLEA-HSDWVRDVAWAPSIGLPTSTI 231
Query: 269 TACGDDAIRVF---QEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK---EPGLLASC 322
+C D RVF +D +S+ P LH+ N V W+ +LA
Sbjct: 232 ASCSQDG-RVFIWTCDDASSNTWSPKL-----LHK-----FNDVVWHVSWSITANILAVS 280
Query: 323 SDDGEVAFWK 332
D +V WK
Sbjct: 281 GGDNKVTLWK 290
Score = 54.7 bits (130), Expect = 1e-07
Identities = 39/143 (27%), Positives = 60/143 (41%), Gaps = 22/143 (15%)
Query: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHS 252
HE + D G RLA+CS DR+V+I+ G I L G H
Sbjct: 12 HEDMIHDAQMDYYGTRLATCSSDRSVKIFDVRNGGQI-------------LIADLRG-HE 57
Query: 253 RTIYDIAWCQ-LTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAW 311
++ +AW + G + +C D + + N ++ +H H H VN V W
Sbjct: 58 GPVWQVAWAHPMYGNILASCSYDRKVIIWREENGTWEK------SHEHAGHDSSVNSVCW 111
Query: 312 NPKEPGLLASC-SDDGEVAFWKY 333
P + GL+ +C S DG ++ Y
Sbjct: 112 APHDYGLILACGSSDGAISLLTY 134
Score = 52.8 bits (125), Expect = 4e-07
Identities = 38/124 (30%), Positives = 56/124 (45%), Gaps = 10/124 (8%)
Query: 32 ASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPC----GNYLASASFDATTCI 87
AS G D I++W E D + E H VR VAW+P + +AS S D I
Sbjct: 183 ASGGCDNLIKLWKEEEDGQWKEEQKLEAHSDWVRDVAWAPSIGLPTSTIASCSQDGRVFI 242
Query: 88 WKKNQDDFECVT----TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
W DD T L + V V+W+ + N+LA D V +W+ + ++ C+
Sbjct: 243 W--TCDDASSNTWSPKLLHKFNDVVWHVSWSITANILAVSGGDNKVTLWKESVDGQWVCI 300
Query: 144 SVLN 147
S +N
Sbjct: 301 SDVN 304
Score = 35.8 bits (81), Expect = 0.056
Identities = 13/41 (31%), Positives = 24/41 (58%), Gaps = 1/41 (2%)
Query: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGD-SWICKSVLSEG 59
W ++W+ +LA GGD ++ +W D W+C S +++G
Sbjct: 266 WHVSWSITANILAVSGGDNKVTLWKESVDGQWVCISDVNKG 306
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 99.4 bits (246), Expect = 4e-21
Identities = 63/208 (30%), Positives = 100/208 (48%), Gaps = 14/208 (6%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSE-GHQRTVRKVAWSPCGNYLASAS 80
++ P +L SCG DR ++ G C +L+ GH + + P G+ LA++S
Sbjct: 358 VSMQPHKDILVSCGEDRLWKVLGLPK----CNVLLTGFGHTDWLSDCCFHPSGDKLATSS 413
Query: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEY 140
D T +W + D C+ T EGH V S W GN +A+ S DK+ +W+V+ E
Sbjct: 414 GDTTVKLWDLCKGD--CILTFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIWDVNSE--- 468
Query: 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
C L HT V + + P L ++S D T+ ++ + +C +L GH ++
Sbjct: 469 RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIW--DARTGICEQSLYGHMHSINDA 526
Query: 201 AFDPSGQRLASCSDDRTVRIW--RQYLP 226
FDP G +ASC ++W R+ LP
Sbjct: 527 IFDPRGHMIASCDACGVTKLWDFRKLLP 554
Score = 89.7 bits (221), Expect = 3e-18
Identities = 57/200 (28%), Positives = 94/200 (47%), Gaps = 16/200 (8%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKS---VLSEGHQRTVRKVAWSPCGNYLASAS 80
++P+G LA+ GD +++W +CK + EGH R V W CGN++AS+S
Sbjct: 402 FHPSGDKLATSSGDTTVKLWD------LCKGDCILTFEGHSRAVWSCTWHSCGNFVASSS 455
Query: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEY 140
D T+ IW N + C TL GH + V S+ + P N L T S DK++ +W+
Sbjct: 456 LDKTSKIWDVNSE--RCRCTLYGHTDSVNSIEFFPFSNTLLTSSADKTLSIWDARTG--- 510
Query: 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
C L H + ++ P ++AS KL+ + + +++ S +
Sbjct: 511 ICEQSLYGHMHSINDAIFDPRGHMIASCDACGVTKLW--DFRKLLPIVSIDIGPSPGNEV 568
Query: 201 AFDPSGQRLASCSDDRTVRI 220
FD SG+ LA S + + +
Sbjct: 569 NFDSSGRVLAQASGNGVIHL 588
Score = 81.3 bits (199), Expect = 1e-15
Identities = 64/242 (26%), Positives = 106/242 (43%), Gaps = 31/242 (12%)
Query: 94 DFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDV 153
D++ HE V V+ P ++L +C D+ +W+V + + HT +
Sbjct: 341 DYKLKNIFRLHELPVSCVSMQPHKDILVSCGEDR---LWKVLGLPKCNVLLTGFGHTDWL 397
Query: 154 KHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCS 213
+HPS + LA++S D TVKL+ + D C T EGH VWS + G +AS S
Sbjct: 398 SDCCFHPSGDKLATSSGDTTVKLWDLCKGD--CILTFEGHSRAVWSCTWHSCGNFVASSS 455
Query: 214 DDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGD 273
D+T +IW S +C CTL G H+ ++ I + + L T+ D
Sbjct: 456 LDKTSKIW---------------DVNSERCRCTLYG-HTDSVNSIEFFPFSNTLLTSSAD 499
Query: 274 DAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKY 333
+ ++ Q SL H+H +N ++P+ ++ASC G W +
Sbjct: 500 KTLSIWDARTGICEQ----SLYGHMH-----SINDAIFDPR-GHMIASCDACGVTKLWDF 549
Query: 334 QR 335
++
Sbjct: 550 RK 551
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 98.6 bits (244), Expect = 7e-21
Identities = 61/199 (30%), Positives = 93/199 (46%), Gaps = 11/199 (5%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
W+P+G L + DR R+W E I EGH V +A+ G+ + DA
Sbjct: 331 WHPSGRFLGTTCYDRSWRLWDLEAQEEILHQ---EGHSMGVYDIAFHQDGSLAGTGGLDA 387
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
+W C+ LEGH E+ + ++P+G +AT S D + VW++ + CV
Sbjct: 388 FGRVWDLRTG--RCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQR---RCV 442
Query: 144 SVLNSHTQDVKHVVWHPSQ-ELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
+ +H V V + P L + +YD+T K++ W TL GHE V L
Sbjct: 443 YTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHP--GWSPLKTLAGHEGKVMGLDI 500
Query: 203 DPSGQRLASCSDDRTVRIW 221
GQ +A+CS DRT ++W
Sbjct: 501 SSDGQLIATCSYDRTFKLW 519
Score = 73.6 bits (179), Expect = 2e-13
Identities = 54/216 (25%), Positives = 92/216 (42%), Gaps = 23/216 (10%)
Query: 15 PDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-EGHQRTVRKVAWSPCG 73
P S C F +P +LA+ ++W C + + GH V + + P
Sbjct: 233 PISYCHF---SPNSKMLATACWSGLCKLWSVPD----CNLLHTLRGHNTNVGAIVFHPKS 285
Query: 74 NY--------LASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSR 125
LAS + D + +W + D E V +EGH V V W PSG L T
Sbjct: 286 TVSLDPKDVNLASCAADGSVKLWSLDSD--EPVADIEGHTVRVARVMWHPSGRFLGTTCY 343
Query: 126 DKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWV 185
D+S +W+++ ++E + H+ V + +H L + D +++ +
Sbjct: 344 DRSWRLWDLEAQEE---ILHQEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW--DLRTGR 398
Query: 186 CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
C LEGH ++ + F P+G +A+ S D T ++W
Sbjct: 399 CIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVW 434
Score = 62.4 bits (150), Expect = 6e-10
Identities = 46/160 (28%), Positives = 74/160 (46%), Gaps = 9/160 (5%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+A++ G+L + G D R+W I + EGH + + + +SP G ++A+ S
Sbjct: 371 IAFHQDGSLAGTGGLDAFGRVWDLRTGRCI---MFLEGHLKEIYGINFSPNGYHIATGSG 427
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAP-SGNLLATCSRDKSVWVWEVDEEDEY 140
D T +W Q CV T+ H+N V V + P GN L T + D + +W +
Sbjct: 428 DNTCKVWDLRQR--RCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWT---HPGW 482
Query: 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREE 180
+ L H V + +L+A+ SYD T KL+ E
Sbjct: 483 SPLKTLAGHEGKVMGLDISSDGQLIATCSYDRTFKLWMAE 522
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 98.2 bits (243), Expect = 9e-21
Identities = 85/314 (27%), Positives = 143/314 (45%), Gaps = 40/314 (12%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
++P G LAS D+ I+IWG D K++ GH+ + VAWS N L SAS D
Sbjct: 53 FSPNGEWLASSSADKLIKIWGAY-DGKFEKTI--SGHKLGISDVAWSSDSNLLVSASDDK 109
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
T IW + +C+ TL+GH N V + P NL+ + S D+SV +W+V +C+
Sbjct: 110 TLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG---KCL 164
Query: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATL-EGHESTVWSLAF 202
L +H+ V V ++ L+ S+SYD +++ + C TL + V + F
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW--DTASGQCLKTLIDDDNPPVSFVKF 222
Query: 203 DPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQ 262
P+G+ + + + D T+++W Y G KC+ T +G + A
Sbjct: 223 SPNGKYILAATLDNTLKLW-DYSKG--------------KCLKTYTGHKNEKYCIFANFS 267
Query: 263 LTGA--LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLA 320
+TG + + D+ + ++ Q+ Q H+ V A +P E ++A
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQK---------LQGHTDVVISTACHPTE-NIIA 317
Query: 321 SCS--DDGEVAFWK 332
S + +D + WK
Sbjct: 318 SAALENDKTIKLWK 331
Score = 92.8 bits (229), Expect = 4e-19
Identities = 53/163 (32%), Positives = 83/163 (50%), Gaps = 7/163 (4%)
Query: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
GH + V V +SP G +LAS+S D IW FE T+ GH+ + VAW+ N
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSDSN 100
Query: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
LL + S DK++ +W+V +C+ L H+ V ++P L+ S S+D++V+++
Sbjct: 101 LLVSASDDKTLKIWDVSSG---KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW- 156
Query: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
+ C TL H V ++ F+ G + S S D RIW
Sbjct: 157 -DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 76.3 bits (186), Expect = 4e-14
Identities = 61/245 (24%), Positives = 112/245 (45%), Gaps = 21/245 (8%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+AW+ LL S D+ ++IW C L +GH V ++P N + S SF
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGK--CLKTL-KGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D + IW +C+ TL H + V +V + G+L+ + S D +W+ +
Sbjct: 150 DESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG---Q 204
Query: 142 CV-SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
C+ ++++ V V + P+ + + +A+ D+T+KL+ + C T GH++ + +
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW--DYSKGKCLKTYTGHKNEKYCI 262
Query: 201 AFDPS---GQRLASCSDDRTVRIWR-------QYLPGNEQGVACSGSDPSWKCICTLSGF 250
+ S G+ + S S+D V IW Q L G+ V + P+ I + +
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALE 322
Query: 251 HSRTI 255
+ +TI
Sbjct: 323 NDKTI 327
Score = 73.9 bits (180), Expect = 2e-13
Identities = 42/122 (34%), Positives = 64/122 (52%), Gaps = 5/122 (4%)
Query: 100 TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWH 159
TL GH V SV ++P+G LA+ S DK + +W + ++E ++ H + V W
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA-YDGKFE--KTISGHKLGISDVAWS 96
Query: 160 PSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVR 219
LL SAS D T+K++ + C TL+GH + V+ F+P + S S D +VR
Sbjct: 97 SDSNLLVSASDDKTLKIW--DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 220 IW 221
IW
Sbjct: 155 IW 156
Score = 58.9 bits (141), Expect = 6e-09
Identities = 57/230 (24%), Positives = 99/230 (43%), Gaps = 35/230 (15%)
Query: 102 EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPS 161
E + E ++ P+ + AT S+ V + Y L HT+ V V + P+
Sbjct: 4 EEKKPETEAARAQPTPSSSATQSKPTPV-------KPNYALKFTLAGHTKAVSSVKFSPN 56
Query: 162 QELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
E LAS+S D +K++ + + T+ GH+ + +A+ L S SDD+T++IW
Sbjct: 57 GEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW 114
Query: 222 RQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281
S KC+ TL G HS ++ + + + + D+++R++
Sbjct: 115 ---------------DVSSGKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIW-- 156
Query: 282 DPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331
D + T AHS V+ V +N ++ L+ S S DG W
Sbjct: 157 DVKTGKCLKTL-------PAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIW 198
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 98.2 bits (243), Expect = 9e-21
Identities = 85/314 (27%), Positives = 143/314 (45%), Gaps = 40/314 (12%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
++P G LAS D+ I+IWG D K++ GH+ + VAWS N L SAS D
Sbjct: 53 FSPNGEWLASSSADKLIKIWGAY-DGKFEKTI--SGHKLGISDVAWSSDSNLLVSASDDK 109
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
T IW + +C+ TL+GH N V + P NL+ + S D+SV +W+V +C+
Sbjct: 110 TLKIWDVSSG--KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIWDVKTG---KCL 164
Query: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATL-EGHESTVWSLAF 202
L +H+ V V ++ L+ S+SYD +++ + C TL + V + F
Sbjct: 165 KTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW--DTASGQCLKTLIDDDNPPVSFVKF 222
Query: 203 DPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQ 262
P+G+ + + + D T+++W Y G KC+ T +G + A
Sbjct: 223 SPNGKYILAATLDNTLKLW-DYSKG--------------KCLKTYTGHKNEKYCIFANFS 267
Query: 263 LTGA--LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLA 320
+TG + + D+ + ++ Q+ Q H+ V A +P E ++A
Sbjct: 268 VTGGKWIVSGSEDNLVYIWNLQTKEIVQK---------LQGHTDVVISTACHPTE-NIIA 317
Query: 321 SCS--DDGEVAFWK 332
S + +D + WK
Sbjct: 318 SAALENDKTIKLWK 331
Score = 92.8 bits (229), Expect = 4e-19
Identities = 53/163 (32%), Positives = 83/163 (50%), Gaps = 7/163 (4%)
Query: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
GH + V V +SP G +LAS+S D IW FE T+ GH+ + VAW+ N
Sbjct: 43 GHTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSDSN 100
Query: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
LL + S DK++ +W+V +C+ L H+ V ++P L+ S S+D++V+++
Sbjct: 101 LLVSASDDKTLKIWDVSSG---KCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVRIW- 156
Query: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
+ C TL H V ++ F+ G + S S D RIW
Sbjct: 157 -DVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIW 198
Score = 76.3 bits (186), Expect = 4e-14
Identities = 61/245 (24%), Positives = 112/245 (45%), Gaps = 21/245 (8%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+AW+ LL S D+ ++IW C L +GH V ++P N + S SF
Sbjct: 93 VAWSSDSNLLVSASDDKTLKIWDVSSGK--CLKTL-KGHSNYVFCCNFNPQSNLIVSGSF 149
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D + IW +C+ TL H + V +V + G+L+ + S D +W+ +
Sbjct: 150 DESVRIWDVKTG--KCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLCRIWDTASG---Q 204
Query: 142 CV-SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
C+ ++++ V V + P+ + + +A+ D+T+KL+ + C T GH++ + +
Sbjct: 205 CLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLW--DYSKGKCLKTYTGHKNEKYCI 262
Query: 201 AFDPS---GQRLASCSDDRTVRIWR-------QYLPGNEQGVACSGSDPSWKCICTLSGF 250
+ S G+ + S S+D V IW Q L G+ V + P+ I + +
Sbjct: 263 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISTACHPTENIIASAALE 322
Query: 251 HSRTI 255
+ +TI
Sbjct: 323 NDKTI 327
Score = 73.9 bits (180), Expect = 2e-13
Identities = 42/122 (34%), Positives = 64/122 (52%), Gaps = 5/122 (4%)
Query: 100 TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWH 159
TL GH V SV ++P+G LA+ S DK + +W + ++E ++ H + V W
Sbjct: 40 TLAGHTKAVSSVKFSPNGEWLASSSADKLIKIWGA-YDGKFE--KTISGHKLGISDVAWS 96
Query: 160 PSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVR 219
LL SAS D T+K++ + C TL+GH + V+ F+P + S S D +VR
Sbjct: 97 SDSNLLVSASDDKTLKIW--DVSSGKCLKTLKGHSNYVFCCNFNPQSNLIVSGSFDESVR 154
Query: 220 IW 221
IW
Sbjct: 155 IW 156
Score = 58.9 bits (141), Expect = 6e-09
Identities = 57/230 (24%), Positives = 99/230 (43%), Gaps = 35/230 (15%)
Query: 102 EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPS 161
E + E ++ P+ + AT S+ V + Y L HT+ V V + P+
Sbjct: 4 EEKKPETEAARAQPTPSSSATQSKPTPV-------KPNYALKFTLAGHTKAVSSVKFSPN 56
Query: 162 QELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
E LAS+S D +K++ + + T+ GH+ + +A+ L S SDD+T++IW
Sbjct: 57 GEWLASSSADKLIKIWGAYDGKFE--KTISGHKLGISDVAWSSDSNLLVSASDDKTLKIW 114
Query: 222 RQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQE 281
S KC+ TL G HS ++ + + + + D+++R++
Sbjct: 115 ---------------DVSSGKCLKTLKG-HSNYVFCCNFNPQSNLIVSGSFDESVRIW-- 156
Query: 282 DPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331
D + T AHS V+ V +N ++ L+ S S DG W
Sbjct: 157 DVKTGKCLKTL-------PAHSDPVSAVHFN-RDGSLIVSSSYDGLCRIW 198
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 97.4 bits (241), Expect = 2e-20
Identities = 74/270 (27%), Positives = 129/270 (47%), Gaps = 38/270 (14%)
Query: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG 117
+GH+ + + SP G LA+AS+D +W N GH++ V SV ++P G
Sbjct: 15 KGHKAAITSLDLSPNGKQLATASWDTFLMLW--NFKPHARAYRYVGHKDVVTSVQFSPHG 72
Query: 118 NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
NLLA+ SRD++V +W D+ ++ S +HT V+ V + + LA+AS D ++K++
Sbjct: 73 NLLASASRDRTVRLWIPDKRGKF---SEFKAHTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 178 REEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGS 237
++ +L H V F P G+ + SCS+D+T++IW
Sbjct: 130 SMYRQRFL--YSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW---------------D 172
Query: 238 DPSWKCICTLS---GFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSL 294
+ +C+ S GF + ++ + +A+A D ++V+ N L
Sbjct: 173 TTNKQCVNNFSDSVGFANFVDFNPSGT----CIASAGSDQTVKVWDVRVN--------KL 220
Query: 295 TAHLHQAHSQDVNCVAWNPKEPGLLASCSD 324
H +Q HS VNC++++P L+ + SD
Sbjct: 221 LQH-YQVHSGGVNCISFHPSGNYLITASSD 249
Score = 87.8 bits (216), Expect = 1e-17
Identities = 58/197 (29%), Positives = 99/197 (50%), Gaps = 10/197 (5%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
++P G LLAS DR +R+W + K + H VR V +S G +LA+AS D
Sbjct: 68 FSPHGNLLASASRDRTVRLWIPDKRG---KFSEFKAHTAPVRSVDFSADGQFLATASEDK 124
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
+ +W + F + +L H + V+ ++P G L+ +CS DK++ +W+ + +CV
Sbjct: 125 SIKVWSMYRQRF--LYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK---QCV 179
Query: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFD 203
+ + V ++PS +ASA D TVK++ + + + H V ++F
Sbjct: 180 NNFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVNKLL--QHYQVHSGGVNCISFH 237
Query: 204 PSGQRLASCSDDRTVRI 220
PSG L + S D T++I
Sbjct: 238 PSGNYLITASSDGTLKI 254
Score = 63.9 bits (154), Expect = 2e-10
Identities = 47/163 (28%), Positives = 73/163 (44%), Gaps = 8/163 (4%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
++P G L+ SC D+ I+IW T + S G V ++P G +ASA D
Sbjct: 152 FSPDGRLIVSCSEDKTIKIWDTTNKQCVNNFSDSVGF---ANFVDFNPSGTCIASAGSDQ 208
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
T +W + + + + H V +++ PSGN L T S D ++ + ++ E +
Sbjct: 209 TVKVWDVRVN--KLLQHYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEG---RLI 263
Query: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVC 186
L HT V V + EL AS D V L+R D+ C
Sbjct: 264 YTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTNFDELHC 306
Score = 61.6 bits (148), Expect = 1e-09
Identities = 37/122 (30%), Positives = 62/122 (50%), Gaps = 6/122 (4%)
Query: 21 FLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASAS 80
F+ +NP+GT +AS G D+ +++W + + + H V +++ P GNYL +AS
Sbjct: 191 FVDFNPSGTCIASAGSDQTVKVWDVRVNKLLQH---YQVHSGGVNCISFHPSGNYLITAS 247
Query: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEY 140
D T I + + TL+GH V +V+++ G L A+ D V +W + DE
Sbjct: 248 SDGTLKILDLLEG--RLIYTLQGHTGPVFTVSFSKGGELFASGGADTQVLLWRTN-FDEL 304
Query: 141 EC 142
C
Sbjct: 305 HC 306
Score = 53.1 bits (126), Expect = 3e-07
Identities = 49/172 (28%), Positives = 77/172 (44%), Gaps = 28/172 (16%)
Query: 160 PSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVR 219
P+ + LA+AS+D + L+ + GH+ V S+ F P G LAS S DRTVR
Sbjct: 28 PNGKQLATASWDTFLMLWNFKPH--ARAYRYVGHKDVVTSVQFSPHGNLLASASRDRTVR 85
Query: 220 IWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVF 279
+W +P G +K H+ + + + LATA D +I+V+
Sbjct: 86 LW---IPDKR------GKFSEFKA-------HTAPVRSVDFSADGQFLATASEDKSIKVW 129
Query: 280 QEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFW 331
+ Q+ +SL H H V C ++P + L+ SCS+D + W
Sbjct: 130 ----SMYRQRFLYSLYRHTHW-----VRCAKFSP-DGRLIVSCSEDKTIKIW 171
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 95.5 bits (236), Expect = 6e-20
Identities = 65/259 (25%), Positives = 120/259 (46%), Gaps = 26/259 (10%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
L++NP TL+A+ D ++W + + GH + ++++ G+ + + SF
Sbjct: 183 LSFNPQSTLVATGSMDTTAKLWDIQNGEEV---YTLRGHSAEIISLSFNTSGDRIITGSF 239
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D T +W + D V L GH E+ S ++ +L+ T S DK+ +W+ +
Sbjct: 240 DHTVVVW--DADTGRKVNILIGHCAEISSASFNWDCSLILTGSMDKTCKLWDATNG---K 294
Query: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLA 201
CV+ L H ++ + + +L+A+AS D T +++ C A LEGHE + ++
Sbjct: 295 CVATLTGHDDEILDSCFDYTGKLIATASADGTARIFSAATRK--CIAKLEGHEGEISKIS 352
Query: 202 FDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWC 261
F+P G L + S D+T RIW + +C+ L G H+ I+ A+
Sbjct: 353 FNPQGNHLLTGSSDKTARIW---------------DAQTGQCLQVLEG-HTDEIFSCAFN 396
Query: 262 QLTGALATACGDDAIRVFQ 280
+ T D+ R+++
Sbjct: 397 YKGNIVITGSKDNTCRIWR 415
Score = 92.0 bits (227), Expect = 7e-19
Identities = 77/304 (25%), Positives = 141/304 (46%), Gaps = 36/304 (11%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS-PCGNYLASAS 80
+A N +G+ + DR ++W T + EGH+ V +A++ P G+ +A+ S
Sbjct: 98 VALNKSGSCFITGSYDRTCKLWDTASGEELNTL---EGHRNVVYAIAFNNPYGDKIATGS 154
Query: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEY 140
FD T +W + + +C T GH E+ +++ P L+AT S D + +W++ +E
Sbjct: 155 FDKTCKLW--SVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLWDIQNGEE- 211
Query: 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
V L H+ ++ + ++ S + + + S+D TV ++ + D L GH + + S
Sbjct: 212 --VYTLRGHSAEIISLSFNTSGDRIITGSFDHTVVVW--DADTGRKVNILIGHCAEISSA 267
Query: 201 AFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAW 260
+F+ + + S D+T ++W A +G KC+ TL+G H I D +
Sbjct: 268 SFNWDCSLILTGSMDKTCKLWD----------ATNG-----KCVATLTG-HDDEILDSCF 311
Query: 261 CQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLA 320
+ATA D R+F T A L + H +++ +++NP+ LL
Sbjct: 312 DYTGKLIATASADGTARIF--------SAATRKCIAKL-EGHEGEISKISFNPQGNHLLT 362
Query: 321 SCSD 324
SD
Sbjct: 363 GSSD 366
Score = 48.1 bits (113), Expect = 1e-05
Identities = 33/122 (27%), Positives = 59/122 (48%), Gaps = 10/122 (8%)
Query: 145 VLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF-D 203
VL +H + +V + S + SYD T KL+ + + TLEGH + V+++AF +
Sbjct: 87 VLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEEL--NTLEGHRNVVYAIAFNN 144
Query: 204 PSGQRLASCSDDRTVRIWR-------QYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIY 256
P G ++A+ S D+T ++W G+ + C +P + T S + ++
Sbjct: 145 PYGDKIATGSFDKTCKLWSVETGKCYHTFRGHTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
Query: 257 DI 258
DI
Sbjct: 205 DI 206
Score = 35.4 bits (80), Expect = 0.073
Identities = 37/164 (22%), Positives = 66/164 (40%), Gaps = 27/164 (16%)
Query: 175 KLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVAC 234
KL + + L+ H + ++A + SG + S DRT ++W
Sbjct: 73 KLGQNSNHTFYLFKVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWD----------TA 122
Query: 235 SGSDPSWKCICTLSGFHSRTIYDIAWCQLTG-ALATACGDDAIRVFQEDPNSDPQQPTFS 293
SG + + TL G H +Y IA+ G +AT D +++ +
Sbjct: 123 SGEE-----LNTLEG-HRNVVYAIAFNNPYGDKIATGSFDKTCKLWSVETGK-------- 168
Query: 294 LTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQRPE 337
H + H+ ++ C+++NP+ L+A+ S D W Q E
Sbjct: 169 -CYHTFRGHTAEIVCLSFNPQST-LVATGSMDTTAKLWDIQNGE 210
>gi|19913369 transducin beta-like 3 [Homo sapiens]
Length = 808
Score = 95.1 bits (235), Expect = 8e-20
Identities = 63/208 (30%), Positives = 102/208 (49%), Gaps = 19/208 (9%)
Query: 28 GTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCG-NYLASASFDATTC 86
G L ASC D+ +RIW + GH +V V S ++L + S D T
Sbjct: 388 GWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSRLKESFLVTGSQDCTVK 447
Query: 87 IW--------KKNQDD-----FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
+W K D + TT H+ ++ SVA AP+ LLAT S+D++ +W
Sbjct: 448 LWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPNDKLLATGSQDRTAKLWA 507
Query: 134 VDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGH 193
+ + + + V + H + + V + P ++LA+AS D T+KL+ + D+ C T EGH
Sbjct: 508 L---PQCQLLGVFSGHRRGLWCVQFSPMDQVLATASADGTIKLWALQ--DFSCLKTFEGH 562
Query: 194 ESTVWSLAFDPSGQRLASCSDDRTVRIW 221
+++V +AF G +L S D V++W
Sbjct: 563 DASVLKVAFVSRGTQLLSSGSDGLVKLW 590
Score = 62.8 bits (151), Expect = 4e-10
Identities = 42/129 (32%), Positives = 61/129 (47%), Gaps = 10/129 (7%)
Query: 26 PAGTLLASCGGDRRIRIWGTEGDSWICKSV-LSEGHQRTVRKVAWSPCGNYLASASFDAT 84
P LLA+ DR ++W C+ + + GH+R + V +SP LA+AS D T
Sbjct: 489 PNDKLLATGSQDRTAKLWALPQ----CQLLGVFSGHRRGLWCVQFSPMDQVLATASADGT 544
Query: 85 TCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVS 144
+W DF C+ T EGH+ V VA+ G L + D V +W + ECV
Sbjct: 545 IKLWALQ--DFSCLKTFEGHDASVLKVAFVSRGTQLLSSGSDGLVKLWTIKNN---ECVR 599
Query: 145 VLNSHTQDV 153
L++H V
Sbjct: 600 TLDAHEDKV 608
Score = 61.2 bits (147), Expect = 1e-09
Identities = 64/251 (25%), Positives = 106/251 (42%), Gaps = 40/251 (15%)
Query: 101 LEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP 160
L GH + V ++ G L A+C++D+SV +W +++ + CV+ + HT V V
Sbjct: 372 LHGHTDIVLALDVFRKGWLFASCAKDQSVRIWRMNKAGQVMCVAQGSGHTHSVGTVCCSR 431
Query: 161 SQE-LLASASYDDTVKLY--------REEEDD-----WVCCATLEGHESTVWSLAFDPSG 206
+E L + S D TVKL+ + D T H+ + S+A P+
Sbjct: 432 LKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAPND 491
Query: 207 QRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA 266
+ LA+ S DRT ++W + P + + SG H R ++ + + +
Sbjct: 492 KLLATGSQDRTAKLW---------------ALPQCQLLGVFSG-HRRGLWCVQFSPMDQV 535
Query: 267 LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDG 326
LATA D I+++ S + H V VA+ + LL+S S DG
Sbjct: 536 LATASADGTIKLWALQDFS---------CLKTFEGHDASVLKVAFVSRGTQLLSSGS-DG 585
Query: 327 EVAFWKYQRPE 337
V W + E
Sbjct: 586 LVKLWTIKNNE 596
Score = 53.9 bits (128), Expect = 2e-07
Identities = 85/378 (22%), Positives = 127/378 (33%), Gaps = 85/378 (22%)
Query: 11 VPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWS 70
V HPD P LL S D IR+W + S C +VL+ H V +A+S
Sbjct: 157 VAFHPD---------PTRLLLFSSATDAAIRVWSLQDRS--CLAVLT-AHYSAVTSLAFS 204
Query: 71 PCGNYLASASFDATTCIWKKNQ----------DDFECVTTLEGHENEVKSVAWAPSGNLL 120
G+ + S+ D IW + E L E V + G
Sbjct: 205 ADGHTMLSSGRDKICIIWDLQSCQATRTVPVFESVEAAVLLP--EEPVSQLGVKSPGLYF 262
Query: 121 ATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREE 180
T ++ VWE + Q++ H + ++ +A+ D + LY
Sbjct: 263 LTAGDQGTLRVWEAASGQCVYTQAQPPGPGQELTHCTLAHTAGVVLTATADHNLLLYEAR 322
Query: 181 -----------------------EDDWV-----------------CCATLEGHESTVWSL 200
ED V C L GH V +L
Sbjct: 323 SLRLQKQFAGYSEEVLDVRFLGPEDSHVVVASNSPCLKVFELQTSACQILHGHTDIVLAL 382
Query: 201 AFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAW 260
G ASC+ D++VRIWR G C+ SG H+ ++ +
Sbjct: 383 DVFRKGWLFASCAKDQSVRIWRMNKAGQVM------------CVAQGSG-HTHSVGTVCC 429
Query: 261 CQLTGA-LATACGDDAIRVFQ-----EDPNSDPQQPTFSLTAHLHQ-AHSQDVNCVAWNP 313
+L + L T D ++++ N+ P L A Q H +D+N VA P
Sbjct: 430 SRLKESFLVTGSQDCTVKLWPLPKALLSKNTAPDNGPILLQAQTTQRCHDKDINSVAIAP 489
Query: 314 KEPGLLASCSDDGEVAFW 331
+ LLA+ S D W
Sbjct: 490 NDK-LLATGSQDRTAKLW 506
Score = 53.1 bits (126), Expect = 3e-07
Identities = 36/123 (29%), Positives = 60/123 (48%), Gaps = 6/123 (4%)
Query: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
W + ++P +LA+ D I++W + S C EGH +V KVA+ G L S+
Sbjct: 525 WCVQFSPMDQVLATASADGTIKLWALQDFS--CLKTF-EGHDASVLKVAFVSRGTQLLSS 581
Query: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVW-EVDEED 138
D +W + ECV TL+ HE++V + + + T + D V +W +V E +
Sbjct: 582 GSDGLVKLWTIKNN--ECVRTLDAHEDKVWGLHCSRLDDHALTGASDSRVILWKDVTEAE 639
Query: 139 EYE 141
+ E
Sbjct: 640 QAE 642
Score = 47.8 bits (112), Expect = 1e-05
Identities = 39/125 (31%), Positives = 61/125 (48%), Gaps = 17/125 (13%)
Query: 104 HENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSH----TQDVKHVV-W 158
H V ++A+ P+ LLAT D +V VW++ V +H + V H+V +
Sbjct: 108 HTAPVATMAFDPTSTLLATGGCDGAVRVWDI--------VRHYGTHHFRGSPGVVHLVAF 159
Query: 159 HP--SQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDR 216
HP ++ LL S++ D ++++ + D C A L H S V SLAF G + S D+
Sbjct: 160 HPDPTRLLLFSSATDAAIRVWSLQ--DRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDK 217
Query: 217 TVRIW 221
IW
Sbjct: 218 ICIIW 222
Score = 47.8 bits (112), Expect = 1e-05
Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 19/135 (14%)
Query: 22 LAWNPAGTLLASCGGDRRIRIW------GTEGDSWICKSVLSEGHQRTVRKVAWSPCGNY 75
+A++P TLLA+ G D +R+W GT G V VA+ P
Sbjct: 115 MAFDPTSTLLATGGCDGAVRVWDIVRHYGTHH---------FRGSPGVVHLVAFHPDPTR 165
Query: 76 LA--SASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
L S++ DA +W + D C+ L H + V S+A++ G+ + + RDK +W+
Sbjct: 166 LLLFSSATDAAIRVW--SLQDRSCLAVLTAHYSAVTSLAFSADGHTMLSSGRDKICIIWD 223
Query: 134 VDEEDEYECVSVLNS 148
+ V V S
Sbjct: 224 LQSCQATRTVPVFES 238
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 94.0 bits (232), Expect = 2e-19
Identities = 64/199 (32%), Positives = 103/199 (51%), Gaps = 14/199 (7%)
Query: 24 WNPAGTLLASCGGDRRIRIW--GTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
++P+G LLAS D+ +RIW +G+S + ++ H TVR V + G +AS
Sbjct: 31 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA-----HTATVRSVHFCSDGQSFVTASD 85
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D T +W ++ F + +L H N V+ ++P G L+ + S DK+V +W ++ E
Sbjct: 86 DKTVKVWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW---DKSSRE 140
Query: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLA 201
CV H V +V +HPS +A+A D+TVK++ + L H + V L+
Sbjct: 141 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL--HSAAVNGLS 198
Query: 202 FDPSGQRLASCSDDRTVRI 220
F PSG L + S D T++I
Sbjct: 199 FHPSGNYLITASSDSTLKI 217
Score = 77.8 bits (190), Expect = 1e-14
Identities = 74/274 (27%), Positives = 109/274 (39%), Gaps = 33/274 (12%)
Query: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
GH+ V V +SP G+ LAS S D T IW N T H V+SV + G
Sbjct: 21 GHKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGES--TVFRAHTATVRSVHFCSDGQ 78
Query: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
T S DK+V VW + + + L+ H V+ + P L+ SAS D TVKL+
Sbjct: 79 SFVTASDDKTVKVWATHRQ---KFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWD 135
Query: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSD 238
+ + C + H V + F PSG +A+ D TV++W D
Sbjct: 136 KSSRE--CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVW----------------D 177
Query: 239 PSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHL 298
+ HS + +++ L TA D +++ D + T H
Sbjct: 178 VRTHRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKIL------DLMEGRLLYTLHG 231
Query: 299 HQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332
HQ VA++ + AS D +V WK
Sbjct: 232 HQG---PATTVAFS-RTGEYFASGGSDEQVMVWK 261
Score = 56.6 bits (135), Expect = 3e-08
Identities = 32/113 (28%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 21 FLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASAS 80
++ ++P+GT +A+ G D +++W + L H V +++ P GNYL +AS
Sbjct: 154 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL---HSAAVNGLSFHPSGNYLITAS 210
Query: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
D+T I + + TL GH+ +VA++ +G A+ D+ V VW+
Sbjct: 211 SDSTLKILDLMEG--RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 261
Score = 37.4 bits (85), Expect = 0.019
Identities = 35/139 (25%), Positives = 53/139 (38%), Gaps = 9/139 (6%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
L+++P+G L + D ++I + GHQ VA+S G Y AS
Sbjct: 197 LSFHPSGNYLITASSDSTLKILDLMEGRLL---YTLHGHQGPATTVAFSRTGEYFASGGS 253
Query: 82 DATTCIWKKN---QDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEED 138
D +WK N D E S+ P + R +SV E +
Sbjct: 254 DEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSV---ESVQSQ 310
Query: 139 EYECVSVLNSHTQDVKHVV 157
E VSV + T ++H+V
Sbjct: 311 PQEPVSVPQTLTSTLEHIV 329
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 94.0 bits (232), Expect = 2e-19
Identities = 64/199 (32%), Positives = 103/199 (51%), Gaps = 14/199 (7%)
Query: 24 WNPAGTLLASCGGDRRIRIW--GTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
++P+G LLAS D+ +RIW +G+S + ++ H TVR V + G +AS
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA-----HTATVRSVHFCSDGQSFVTASD 123
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D T +W ++ F + +L H N V+ ++P G L+ + S DK+V +W ++ E
Sbjct: 124 DKTVKVWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW---DKSSRE 178
Query: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLA 201
CV H V +V +HPS +A+A D+TVK++ + L H + V L+
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL--HSAAVNGLS 236
Query: 202 FDPSGQRLASCSDDRTVRI 220
F PSG L + S D T++I
Sbjct: 237 FHPSGNYLITASSDSTLKI 255
Score = 82.4 bits (202), Expect = 5e-16
Identities = 75/268 (27%), Positives = 121/268 (45%), Gaps = 34/268 (12%)
Query: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG 117
+GH+ V V +S LAS S D+ +W T GH++ V V ++PSG
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSG 73
Query: 118 NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
+LLA+ SRDK+V +W + + E +V +HT V+ V + + +AS D TVK++
Sbjct: 74 HLLASGSRDKTVRIWVPNVKGE---STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 178 REEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGS 237
++ +L H + V F P G+ + S SDD+TV++W ++ C S
Sbjct: 131 ATHRQKFL--FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW------DKSSRECVHS 182
Query: 238 DPSWKCICTLSGFHSRTIYDIAWCQLTGALATACG-DDAIRVFQEDPNSDPQQPTFSLTA 296
T FH +G A G D+ ++V+ T L
Sbjct: 183 YCEHGGFVTYVDFHP-----------SGTCIAAAGMDNTVKVW--------DVRTHRLLQ 223
Query: 297 HLHQAHSQDVNCVAWNPKEPGLLASCSD 324
H +Q HS VN ++++P L+ + SD
Sbjct: 224 H-YQLHSAAVNGLSFHPSGNYLITASSD 250
Score = 56.6 bits (135), Expect = 3e-08
Identities = 32/113 (28%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 21 FLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASAS 80
++ ++P+GT +A+ G D +++W + L H V +++ P GNYL +AS
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL---HSAAVNGLSFHPSGNYLITAS 248
Query: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
D+T I + + TL GH+ +VA++ +G A+ D+ V VW+
Sbjct: 249 SDSTLKILDLMEG--RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 36.2 bits (82), Expect = 0.043
Identities = 21/72 (29%), Positives = 31/72 (43%), Gaps = 3/72 (4%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
L+++P+G L + D ++I + GHQ VA+S G Y AS
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLL---YTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 82 DATTCIWKKNQD 93
D +WK N D
Sbjct: 292 DEQVMVWKSNFD 303
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 94.0 bits (232), Expect = 2e-19
Identities = 64/199 (32%), Positives = 103/199 (51%), Gaps = 14/199 (7%)
Query: 24 WNPAGTLLASCGGDRRIRIW--GTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
++P+G LLAS D+ +RIW +G+S + ++ H TVR V + G +AS
Sbjct: 69 FSPSGHLLASGSRDKTVRIWVPNVKGESTVFRA-----HTATVRSVHFCSDGQSFVTASD 123
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D T +W ++ F + +L H N V+ ++P G L+ + S DK+V +W ++ E
Sbjct: 124 DKTVKVWATHRQKF--LFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW---DKSSRE 178
Query: 142 CVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLA 201
CV H V +V +HPS +A+A D+TVK++ + L H + V L+
Sbjct: 179 CVHSYCEHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL--HSAAVNGLS 236
Query: 202 FDPSGQRLASCSDDRTVRI 220
F PSG L + S D T++I
Sbjct: 237 FHPSGNYLITASSDSTLKI 255
Score = 82.4 bits (202), Expect = 5e-16
Identities = 75/268 (27%), Positives = 121/268 (45%), Gaps = 34/268 (12%)
Query: 58 EGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSG 117
+GH+ V V +S LAS S D+ +W T GH++ V V ++PSG
Sbjct: 16 KGHRDAVTCVDFSINTKQLASGSMDSCLMVWHMKPQSRAYRFT--GHKDAVTCVNFSPSG 73
Query: 118 NLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
+LLA+ SRDK+V +W + + E +V +HT V+ V + + +AS D TVK++
Sbjct: 74 HLLASGSRDKTVRIWVPNVKGE---STVFRAHTATVRSVHFCSDGQSFVTASDDKTVKVW 130
Query: 178 REEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGS 237
++ +L H + V F P G+ + S SDD+TV++W ++ C S
Sbjct: 131 ATHRQKFL--FSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLW------DKSSRECVHS 182
Query: 238 DPSWKCICTLSGFHSRTIYDIAWCQLTGALATACG-DDAIRVFQEDPNSDPQQPTFSLTA 296
T FH +G A G D+ ++V+ T L
Sbjct: 183 YCEHGGFVTYVDFHP-----------SGTCIAAAGMDNTVKVW--------DVRTHRLLQ 223
Query: 297 HLHQAHSQDVNCVAWNPKEPGLLASCSD 324
H +Q HS VN ++++P L+ + SD
Sbjct: 224 H-YQLHSAAVNGLSFHPSGNYLITASSD 250
Score = 56.6 bits (135), Expect = 3e-08
Identities = 32/113 (28%), Positives = 58/113 (51%), Gaps = 5/113 (4%)
Query: 21 FLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASAS 80
++ ++P+GT +A+ G D +++W + L H V +++ P GNYL +AS
Sbjct: 192 YVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQHYQL---HSAAVNGLSFHPSGNYLITAS 248
Query: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
D+T I + + TL GH+ +VA++ +G A+ D+ V VW+
Sbjct: 249 SDSTLKILDLMEG--RLLYTLHGHQGPATTVAFSRTGEYFASGGSDEQVMVWK 299
Score = 37.4 bits (85), Expect = 0.019
Identities = 35/139 (25%), Positives = 53/139 (38%), Gaps = 9/139 (6%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
L+++P+G L + D ++I + GHQ VA+S G Y AS
Sbjct: 235 LSFHPSGNYLITASSDSTLKILDLMEGRLL---YTLHGHQGPATTVAFSRTGEYFASGGS 291
Query: 82 DATTCIWKKN---QDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEED 138
D +WK N D E S+ P + R +SV E +
Sbjct: 292 DEQVMVWKSNFDIVDHGEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSV---ESVQSQ 348
Query: 139 EYECVSVLNSHTQDVKHVV 157
E VSV + T ++H+V
Sbjct: 349 PQEPVSVPQTLTSTLEHIV 367
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 93.6 bits (231), Expect = 2e-19
Identities = 103/388 (26%), Positives = 155/388 (39%), Gaps = 100/388 (25%)
Query: 22 LAWNPAGTLLASCGGDRRIRIW--GTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
+A++P G LAS GD +R W TE + CK GH+ V ++WSP G LAS
Sbjct: 120 VAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCK-----GHRHWVLSISWSPDGRKLASG 174
Query: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWA-----PSGNLLATCSRDKSVWVWEV 134
+ +W + + TL GH + ++W P +A+ S+D SV +W+
Sbjct: 175 CKNGQILLWDPSTGK-QVGRTLAGHSKWITGLSWEPLHANPECRYVASSSKDGSVRIWDT 233
Query: 135 DEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHE 194
C +L HTQ V + W LL SAS D T+K++R D V C TL+GH
Sbjct: 234 TAG---RCERILTGHTQSVTCLRW-GGDGLLYSASQDRTIKVWRAH--DGVLCRTLQGHG 287
Query: 195 --------STVWSL---AFDPS-------------------------------GQRLASC 212
ST ++L AF+P+ +RL S
Sbjct: 288 HWVNTMALSTDYALRTGAFEPAEASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSG 347
Query: 213 SDDRTVRIW-------------------RQYLPGNEQGVACSGS-DPS---W-----KCI 244
SDD T+ +W Q L + + S S D S W K +
Sbjct: 348 SDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYL 407
Query: 245 CTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQ 304
+L G H +Y IAW + L + D ++V+ + Q+ L H+
Sbjct: 408 ASLRG-HVAAVYQIAWSADSRLLVSGSSDSTLKVW----DVKAQKLAMDL-----PGHAD 457
Query: 305 DVNCVAWNPKEPGLLASCSDDGEVAFWK 332
+V V W+P + +AS D + W+
Sbjct: 458 EVYAVDWSP-DGQRVASGGKDKCLRIWR 484
Score = 81.6 bits (200), Expect = 9e-16
Identities = 60/190 (31%), Positives = 92/190 (48%), Gaps = 22/190 (11%)
Query: 52 CKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQD--DFECVTTLEGHENEVK 109
C S L EGH V VA+SP G YLAS S D T W + + F C +GH + V
Sbjct: 106 CTSSL-EGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTC----KGHRHWVL 160
Query: 110 SVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVW-----HPSQEL 164
S++W+P G LA+ ++ + +W D + L H++ + + W +P
Sbjct: 161 SISWSPDGRKLASGCKNGQILLW--DPSTGKQVGRTLAGHSKWITGLSWEPLHANPECRY 218
Query: 165 LASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQY 224
+AS+S D +V+++ + C L GH +V L + G L S S DRT+++WR +
Sbjct: 219 VASSSKDGSVRIW--DTTAGRCERILTGHTQSVTCLRWGGDG-LLYSASQDRTIKVWRAH 275
Query: 225 LPGNEQGVAC 234
GV C
Sbjct: 276 -----DGVLC 280
Score = 78.6 bits (192), Expect = 8e-15
Identities = 61/242 (25%), Positives = 103/242 (42%), Gaps = 48/242 (19%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGH--------------------- 60
L W G LL S DR I++W D +C+++ GH
Sbjct: 252 LRWGGDG-LLYSASQDRTIKVWRAH-DGVLCRTLQGHGHWVNTMALSTDYALRTGAFEPA 309
Query: 61 ---------QRTVRKVAWSPCGNY----------LASASFDATTCIWKKNQDDFECVTTL 101
Q +++++ Y L S S D T +W +D + +T +
Sbjct: 310 EASVNPQDLQGSLQELKERALSRYNLVRGQGPERLVSGSDDFTLFLWSPAEDK-KPLTRM 368
Query: 102 EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPS 161
GH+ + V ++P ++A+ S DKS+ +W+ +Y ++ L H V + W
Sbjct: 369 TGHQALINQVLFSPDSRIVASASFDKSIKLWD-GRTGKY--LASLRGHVAAVYQIAWSAD 425
Query: 162 QELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
LL S S D T+K++ + L GH V+++ + P GQR+AS D+ +RIW
Sbjct: 426 SRLLVSGSSDSTLKVWDVKAQK--LAMDLPGHADEVYAVDWSPDGQRVASGGKDKCLRIW 483
Query: 222 RQ 223
R+
Sbjct: 484 RR 485
Score = 64.7 bits (156), Expect = 1e-10
Identities = 74/261 (28%), Positives = 109/261 (41%), Gaps = 36/261 (13%)
Query: 97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHV 156
C ++LEGH V SVA++P+G LA+ S D +V W++ E + H V +
Sbjct: 106 CTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPH---FTCKGHRHWVLSI 162
Query: 157 VWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFD-----PSGQRLAS 211
W P LAS + + L+ V TL GH + L+++ P + +AS
Sbjct: 163 SWSPDGRKLASGCKNGQILLWDPSTGKQV-GRTLAGHSKWITGLSWEPLHANPECRYVAS 221
Query: 212 CSDDRTVRIW-------RQYLPGNEQGVAC-----------SGSDPSWKCICTLSGFHSR 253
S D +VRIW + L G+ Q V C + D + K G R
Sbjct: 222 SSKDGSVRIWDTTAGRCERILTGHTQSVTCLRWGGDGLLYSASQDRTIKVWRAHDGVLCR 281
Query: 254 TIYDIAWCQLTGALATACGDDAIRVFQEDP---NSDPQQPTFSLTAHLHQAHSQDVNCVA 310
T+ T AL+T D A+R +P + +PQ SL +A S+ N V
Sbjct: 282 TLQGHGHWVNTMALST---DYALRTGAFEPAEASVNPQDLQGSLQELKERALSR-YNLV- 336
Query: 311 WNPKEPGLLASCSDDGEVAFW 331
+ P L S SDD + W
Sbjct: 337 -RGQGPERLVSGSDDFTLFLW 356
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 92.4 bits (228), Expect = 5e-19
Identities = 62/201 (30%), Positives = 100/201 (49%), Gaps = 8/201 (3%)
Query: 21 FLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASAS 80
F ++P G L AS D +R+W C VL +GHQR+V V++SP LAS
Sbjct: 68 FCRFSPDGHLFASASCDCTVRLWDVARAK--CLRVL-KGHQRSVETVSFSPDSRQLASGG 124
Query: 81 FDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEY 140
+D +W + + L GH + ++S ++P+ N LAT S D +V +W++
Sbjct: 125 WDKRVMLWDVQSG--QMLRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPA 182
Query: 141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
L H+ ++ + + S LLAS S+D T+ +++ + L+GH + V S+
Sbjct: 183 VSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPTTSSLLI--QLKGHVTWVKSI 239
Query: 201 AFDPSGQRLASCSDDRTVRIW 221
AF P LAS R V++W
Sbjct: 240 AFSPDELWLASAGYSRMVKVW 260
Score = 84.7 bits (208), Expect = 1e-16
Identities = 59/201 (29%), Positives = 100/201 (49%), Gaps = 10/201 (4%)
Query: 23 AWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFD 82
A++P G +L + D + W T + + GH V+ +SP G+ ASAS D
Sbjct: 28 AFSPDGQMLLTGSEDGCVYGWETRSGQLLWRL---GGHTGPVKFCRFSPDGHLFASASCD 84
Query: 83 ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYEC 142
T +W + +C+ L+GH+ V++V+++P LA+ DK V +W+V +
Sbjct: 85 CTVRLWDVARA--KCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG---QM 139
Query: 143 VSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY-REEEDDWVCCATLEGHESTVWSLA 201
+ +L H ++ + P+ LA+ S+D TV ++ V LEGH + + L
Sbjct: 140 LRLLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSANISCLC 199
Query: 202 FDPSGQRLASCSDDRTVRIWR 222
+ SG LAS S D+T+ IW+
Sbjct: 200 YSASG-LLASGSWDKTIHIWK 219
Score = 83.6 bits (205), Expect = 2e-16
Identities = 62/204 (30%), Positives = 101/204 (49%), Gaps = 20/204 (9%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
++++P LAS G D+R+ +W + + V GH+ +++ +SP N LA+ S+
Sbjct: 111 VSFSPDSRQLASGGWDKRVMLWDVQSGQMLRLLV---GHRDSIQSSDFSPTVNCLATGSW 167
Query: 82 DATTCIWKKNQDDFECVT------TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVD 135
D+T IW D VT LEGH + + ++ SG LLA+ S DK++ +W+
Sbjct: 168 DSTVHIW-----DLRMVTPAVSHQALEGHSANISCLCYSASG-LLASGSWDKTIHIWKPT 221
Query: 136 EEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHES 195
+ L H VK + + P + LASA Y VK++ + + C TL+G
Sbjct: 222 TSS---LLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVW--DCNTGKCLETLKGVLD 276
Query: 196 TVWSLAFDPSGQRLASCSDDRTVR 219
+ AF P G+ L S + D+T R
Sbjct: 277 VAHTCAFTPDGKILVSGAADQTRR 300
Score = 79.7 bits (195), Expect = 3e-15
Identities = 65/236 (27%), Positives = 103/236 (43%), Gaps = 43/236 (18%)
Query: 104 HENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQE 163
H EV S A++P G +L T S D V+ WE + + L HT VK + P
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSG---QLLWRLGGHTGPVKFCRFSPDGH 76
Query: 164 LLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW-- 221
L ASAS D TV+L+ C L+GH+ +V +++F P ++LAS D+ V +W
Sbjct: 77 LFASASCDCTVRLWDVARAK--CLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDV 134
Query: 222 -----RQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGALATACGDDAI 276
+ L G+ + S P+ C LAT D +
Sbjct: 135 QSGQMLRLLVGHRDSIQSSDFSPTVNC-----------------------LATGSWDSTV 171
Query: 277 RVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWK 332
++ D + T +++ + HS +++C+ ++ GLLAS S D + WK
Sbjct: 172 HIW------DLRMVTPAVSHQALEGHSANISCLCYSAS--GLLASGSWDKTIHIWK 219
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 92.0 bits (227), Expect = 7e-19
Identities = 56/163 (34%), Positives = 82/163 (50%), Gaps = 7/163 (4%)
Query: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
GH V V +SP G +LAS+S D IW +E TL GH E+ VAW+ +
Sbjct: 39 GHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE--KTLYGHNLEISDVAWSSDSS 96
Query: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
L + S DK++ +W+V +C+ L H+ V ++P L+ S S+D+TVK++
Sbjct: 97 RLVSASDDKTLKLWDVRSG---KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIW- 152
Query: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
E C TL H V ++ F+ SG + S S D RIW
Sbjct: 153 -EVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW 194
Score = 91.3 bits (225), Expect = 1e-18
Identities = 61/199 (30%), Positives = 98/199 (49%), Gaps = 11/199 (5%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
++P G LAS DR I IWG + GH + VAWS + L SAS D
Sbjct: 49 FSPNGEWLASSSADRLIIIWGAYDGKY---EKTLYGHNLEISDVAWSSDSSRLVSASDDK 105
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
T +W +C+ TL+GH N V + P NL+ + S D++V +WEV +C+
Sbjct: 106 TLKLWDVRSG--KCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTG---KCL 160
Query: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATL-EGHESTVWSLAF 202
L++H+ V V ++ S L+ S SYD +++ + C TL + V + F
Sbjct: 161 KTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIW--DAASGQCLKTLVDDDNPPVSFVKF 218
Query: 203 DPSGQRLASCSDDRTVRIW 221
P+G+ + + + D T+++W
Sbjct: 219 SPNGKYILTATLDNTLKLW 237
Score = 75.5 bits (184), Expect = 6e-14
Identities = 63/245 (25%), Positives = 113/245 (46%), Gaps = 21/245 (8%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+AW+ + L S D+ +++W S C L +GH V ++P N + S SF
Sbjct: 89 VAWSSDSSRLVSASDDKTLKLWDVR--SGKCLKTL-KGHSNYVFCCNFNPPSNLIISGSF 145
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D T IW+ +C+ TL H + V +V + SG+L+ + S D +W+ +
Sbjct: 146 DETVKIWEVKTG--KCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASG---Q 200
Query: 142 CVSVL-NSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
C+ L + V V + P+ + + +A+ D+T+KL+ + C T GH++ + +
Sbjct: 201 CLKTLVDDDNPPVSFVKFSPNGKYILTATLDNTLKLW--DYSRGRCLKTYTGHKNEKYCI 258
Query: 201 AFDPS---GQRLASCSDDRTVRIWR-------QYLPGNEQGVACSGSDPSWKCICTLSGF 250
+ S G+ + S S+D V IW Q L G+ V + P+ I + +
Sbjct: 259 FANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHTDVVISAACHPTENLIASAALE 318
Query: 251 HSRTI 255
+ +TI
Sbjct: 319 NDKTI 323
Score = 72.4 bits (176), Expect = 5e-13
Identities = 43/122 (35%), Positives = 63/122 (51%), Gaps = 5/122 (4%)
Query: 100 TLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWH 159
TL GH V SV ++P+G LA+ S D+ + +W + +YE L H ++ V W
Sbjct: 36 TLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGA-YDGKYE--KTLYGHNLEISDVAWS 92
Query: 160 PSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVR 219
L SAS D T+KL+ + C TL+GH + V+ F+P + S S D TV+
Sbjct: 93 SDSSRLVSASDDKTLKLW--DVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVK 150
Query: 220 IW 221
IW
Sbjct: 151 IW 152
Score = 67.8 bits (164), Expect = 1e-11
Identities = 48/159 (30%), Positives = 76/159 (47%), Gaps = 12/159 (7%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
+N +G+L+ S D RIW + S C L + V V +SP G Y+ +A+ D
Sbjct: 175 FNCSGSLIVSGSYDGLCRIW--DAASGQCLKTLVDDDNPPVSFVKFSPNGKYILTATLDN 232
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAW---APSGNLLATCSRDKSVWVWEVDEEDEY 140
T +W ++ C+ T GH+NE + G + + S D V++W + +
Sbjct: 233 TLKLWDYSRG--RCLKTYTGHKNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTK--- 287
Query: 141 ECVSVLNSHTQDVKHVVWHPSQELLASASY--DDTVKLY 177
E V L HT V HP++ L+ASA+ D T+KL+
Sbjct: 288 EIVQKLQGHTDVVISAACHPTENLIASAALENDKTIKLW 326
Score = 58.9 bits (141), Expect = 6e-09
Identities = 55/218 (25%), Positives = 92/218 (42%), Gaps = 31/218 (14%)
Query: 133 EVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEG 192
EV E Y L HT+ V V + P+ E LAS+S D + ++ + + TL G
Sbjct: 24 EVPENPNYALKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYE--KTLYG 81
Query: 193 HESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHS 252
H + +A+ RL S SDD+T+++W S KC+ TL G HS
Sbjct: 82 HNLEISDVAWSSDSSRLVSASDDKTLKLW---------------DVRSGKCLKTLKG-HS 125
Query: 253 RTIYDIAWCQLTGALATACGDDAIRVFQE---------DPNSDPQQPT-FSLTAHLHQAH 302
++ + + + + D+ +++++ +SDP F+ + L +
Sbjct: 126 NYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSG 185
Query: 303 SQDVNCVAWNPKEPGLLASCSDDGE--VAFWKYQRPEG 338
S D C W+ L + DD V+F K+ P G
Sbjct: 186 SYDGLCRIWDAASGQCLKTLVDDDNPPVSFVKFS-PNG 222
>gi|169403944 WD repeat domain 26 isoform b [Homo sapiens]
Length = 498
Score = 86.7 bits (213), Expect = 3e-17
Identities = 83/317 (26%), Positives = 133/317 (41%), Gaps = 39/317 (12%)
Query: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-EGHQRTVRKVAWSPCGNYLAS 78
WF ++ GT LA+ D + IW + D+ + K + + EGH V +AWSP NYL +
Sbjct: 196 WFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVA 255
Query: 79 ASFDATTCIWKKNQDDFECVTTL-EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEE 137
D + +W N E T + + HE+ + SVAW P G T + + ++D
Sbjct: 256 CGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGN 315
Query: 138 --DEYECVSVLNSHT-QDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHE 194
D +E V V D K V+ + + + +++D +ED + T+ +
Sbjct: 316 LLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKN- 374
Query: 195 STVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRT 254
+ L G L D VR + QGV GF+ T
Sbjct: 375 GRLALLNVATQGVHLWDLQDRVLVRKY--------QGVT--------------QGFY--T 410
Query: 255 IYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK 314
I+ +A+ D + ++ + + P LT H ++ VNCV+WNP+
Sbjct: 411 IHSCFGGHNEDFIASGSEDHKVYIWHKRS----ELPIAELTGH-----TRTVNCVSWNPQ 461
Query: 315 EPGLLASCSDDGEVAFW 331
P ++AS SDDG V W
Sbjct: 462 IPSMMASASDDGTVRIW 478
Score = 56.2 bits (134), Expect = 4e-08
Identities = 36/112 (32%), Positives = 53/112 (47%), Gaps = 7/112 (6%)
Query: 53 KSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDD--FECVTTLEGHENEVKS 110
+ +L+E H V +S G LA+ S D T IW+ + D + + TLEGH V
Sbjct: 185 QQILTE-HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSY 243
Query: 111 VAWAPSGNLLATCSRD--KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP 160
+AW+P N L C D +W+W V + +S SH + V W+P
Sbjct: 244 IAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMS--QSHEDSLTSVAWNP 293
Score = 39.7 bits (91), Expect = 0.004
Identities = 36/127 (28%), Positives = 49/127 (38%), Gaps = 24/127 (18%)
Query: 190 LEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS---WKCICT 246
L H + VW F G +LA+ S D TV IW+ DP K + T
Sbjct: 188 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQ--------------VDPDTHLLKLLKT 233
Query: 247 LSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDV 306
L G H+ + IAW L DD ++ + T L + Q+H +
Sbjct: 234 LEG-HAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQ------TGELRTKMSQSHEDSL 286
Query: 307 NCVAWNP 313
VAWNP
Sbjct: 287 TSVAWNP 293
Score = 35.8 bits (81), Expect = 0.056
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 4/98 (4%)
Query: 128 SVWVWEVDEEDEYECVS--VLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWV 185
S+ + V ++ C + +L H +V + LA+ S D TV +++ + D +
Sbjct: 168 SLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHL 227
Query: 186 C--CATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
TLEGH V +A+ P L +C D +W
Sbjct: 228 LKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELW 265
Score = 32.3 bits (72), Expect = 0.62
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 267 LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDD- 325
LAT D + ++Q DP++ + +L + H+ V+ +AW+P + L+A DD
Sbjct: 207 LATGSKDTTVIIWQVDPDTHLLKLLKTL-----EGHAYGVSYIAWSPDDNYLVACGPDDC 261
Query: 326 GEVAFWKYQRPE 337
E+ W Q E
Sbjct: 262 SELWLWNVQTGE 273
>gi|55743153 WD repeat domain 26 isoform a [Homo sapiens]
Length = 514
Score = 86.7 bits (213), Expect = 3e-17
Identities = 83/317 (26%), Positives = 133/317 (41%), Gaps = 39/317 (12%)
Query: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLS-EGHQRTVRKVAWSPCGNYLAS 78
WF ++ GT LA+ D + IW + D+ + K + + EGH V +AWSP NYL +
Sbjct: 212 WFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSYIAWSPDDNYLVA 271
Query: 79 ASFDATTCIWKKNQDDFECVTTL-EGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEE 137
D + +W N E T + + HE+ + SVAW P G T + + ++D
Sbjct: 272 CGPDDCSELWLWNVQTGELRTKMSQSHEDSLTSVAWNPDGKRFVTGGQRGQFYQCDLDGN 331
Query: 138 --DEYECVSVLNSHT-QDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHE 194
D +E V V D K V+ + + + +++D +ED + T+ +
Sbjct: 332 LLDSWEGVRVQCLWCLSDGKTVLASDTHQRIRGYNFEDLTDRNIVQEDHPIMSFTISKN- 390
Query: 195 STVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRT 254
+ L G L D VR + QGV GF+ T
Sbjct: 391 GRLALLNVATQGVHLWDLQDRVLVRKY--------QGVT--------------QGFY--T 426
Query: 255 IYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPK 314
I+ +A+ D + ++ + + P LT H ++ VNCV+WNP+
Sbjct: 427 IHSCFGGHNEDFIASGSEDHKVYIWHKRS----ELPIAELTGH-----TRTVNCVSWNPQ 477
Query: 315 EPGLLASCSDDGEVAFW 331
P ++AS SDDG V W
Sbjct: 478 IPSMMASASDDGTVRIW 494
Score = 56.2 bits (134), Expect = 4e-08
Identities = 36/112 (32%), Positives = 53/112 (47%), Gaps = 7/112 (6%)
Query: 53 KSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDD--FECVTTLEGHENEVKS 110
+ +L+E H V +S G LA+ S D T IW+ + D + + TLEGH V
Sbjct: 201 QQILTE-HCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHLLKLLKTLEGHAYGVSY 259
Query: 111 VAWAPSGNLLATCSRD--KSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHP 160
+AW+P N L C D +W+W V + +S SH + V W+P
Sbjct: 260 IAWSPDDNYLVACGPDDCSELWLWNVQTGELRTKMS--QSHEDSLTSVAWNP 309
Score = 39.7 bits (91), Expect = 0.004
Identities = 36/127 (28%), Positives = 49/127 (38%), Gaps = 24/127 (18%)
Query: 190 LEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPS---WKCICT 246
L H + VW F G +LA+ S D TV IW+ DP K + T
Sbjct: 204 LTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQ--------------VDPDTHLLKLLKT 249
Query: 247 LSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDV 306
L G H+ + IAW L DD ++ + T L + Q+H +
Sbjct: 250 LEG-HAYGVSYIAWSPDDNYLVACGPDDCSELWLWNVQ------TGELRTKMSQSHEDSL 302
Query: 307 NCVAWNP 313
VAWNP
Sbjct: 303 TSVAWNP 309
Score = 35.8 bits (81), Expect = 0.056
Identities = 25/98 (25%), Positives = 43/98 (43%), Gaps = 4/98 (4%)
Query: 128 SVWVWEVDEEDEYECVS--VLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWV 185
S+ + V ++ C + +L H +V + LA+ S D TV +++ + D +
Sbjct: 184 SLLIDHVCSRRQFPCYTQQILTEHCNEVWFCKFSNDGTKLATGSKDTTVIIWQVDPDTHL 243
Query: 186 C--CATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
TLEGH V +A+ P L +C D +W
Sbjct: 244 LKLLKTLEGHAYGVSYIAWSPDDNYLVACGPDDCSELW 281
Score = 32.3 bits (72), Expect = 0.62
Identities = 21/72 (29%), Positives = 36/72 (50%), Gaps = 6/72 (8%)
Query: 267 LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDD- 325
LAT D + ++Q DP++ + +L + H+ V+ +AW+P + L+A DD
Sbjct: 223 LATGSKDTTVIIWQVDPDTHLLKLLKTL-----EGHAYGVSYIAWSPDDNYLVACGPDDC 277
Query: 326 GEVAFWKYQRPE 337
E+ W Q E
Sbjct: 278 SELWLWNVQTGE 289
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 85.5 bits (210), Expect = 6e-17
Identities = 58/199 (29%), Positives = 94/199 (47%), Gaps = 10/199 (5%)
Query: 23 AWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFD 82
+++P L S D +R+W + ++ C V +GH V +SP G Y S D
Sbjct: 550 SFSPDRNYLLSSSEDGTVRLWSLQ--TFTCL-VGYKGHNYPVWDTQFSPYGYYFVSGGHD 606
Query: 83 ATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYEC 142
+W D ++ + GH +V + P+ N +AT S D++V +W+V + C
Sbjct: 607 RVARLWAT--DHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWDVLNGN---C 661
Query: 143 VSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAF 202
V + H + + + P+ LA+ + D V L+ + + L+GH TV SL F
Sbjct: 662 VRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW--DIGHGLMVGELKGHTDTVCSLRF 719
Query: 203 DPSGQRLASCSDDRTVRIW 221
G+ LAS S D TVR+W
Sbjct: 720 SRDGEILASGSMDNTVRLW 738
Score = 80.5 bits (197), Expect = 2e-15
Identities = 48/163 (29%), Positives = 77/163 (47%), Gaps = 7/163 (4%)
Query: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
GH V ++SP NYL S+S D T +W + F C+ +GH V ++P G
Sbjct: 541 GHSGPVYGASFSPDRNYLLSSSEDGTVRLW--SLQTFTCLVGYKGHNYPVWDTQFSPYGY 598
Query: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
+ D+ +W D Y+ + + H DV +HP+ +A+ S D TV+L+
Sbjct: 599 YFVSGGHDRVARLWAT---DHYQPLRIFAGHLADVNCTRFHPNSNYVATGSADRTVRLWD 655
Query: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
+ C GH+ + SL F P+G+ LA+ + D V +W
Sbjct: 656 VLNGN--CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLW 696
Score = 73.9 bits (180), Expect = 2e-13
Identities = 48/158 (30%), Positives = 75/158 (47%), Gaps = 8/158 (5%)
Query: 20 WFLAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASA 79
W ++P G S G DR R+W T+ + + GH V + P NY+A+
Sbjct: 589 WDTQFSPYGYYFVSGGHDRVARLWATDHYQPL---RIFAGHLADVNCTRFHPNSNYVATG 645
Query: 80 SFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDE 139
S D T +W + CV GH+ + S+ ++P+G LAT + D V +W++
Sbjct: 646 SADRTVRLWDVLNGN--CVRIFTGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHG-- 701
Query: 140 YECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
V L HT V + + E+LAS S D+TV+L+
Sbjct: 702 -LMVGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLW 738
Score = 51.2 bits (121), Expect = 1e-06
Identities = 29/110 (26%), Positives = 56/110 (50%), Gaps = 5/110 (4%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
++P +A+ DR +R+W + C + + GH+ + + +SP G +LA+ + D
Sbjct: 635 FHPNSNYVATGSADRTVRLWDVLNGN--CVRIFT-GHKGPIHSLTFSPNGRFLATGATDG 691
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
+W V L+GH + V S+ ++ G +LA+ S D +V +W+
Sbjct: 692 RVLLWDIGHGLM--VGELKGHTDTVCSLRFSRDGEILASGSMDNTVRLWD 739
Score = 41.2 bits (95), Expect = 0.001
Identities = 44/185 (23%), Positives = 68/185 (36%), Gaps = 36/185 (19%)
Query: 157 VWHPSQELLASASYDDTVKLYREEEDDWVC----------CATLEGHESTVWSLAFDPSG 206
VW + + L S + L +E DD + L GH V+ +F P
Sbjct: 496 VWSVTPKKLRSVKQASDLSLIDKESDDVLERIMDEKTASELKILYGHSGPVYGASFSPDR 555
Query: 207 QRLASCSDDRTVRIWRQYLPGNEQGVACSGSDPSWKCICTLSGFHSRTIYDIAWCQLTGA 266
L S S+D TVR+W S ++ C+ G H+ ++D +
Sbjct: 556 NYLLSSSEDGTVRLW---------------SLQTFTCLVGYKG-HNYPVWDTQFSPYGYY 599
Query: 267 LATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDG 326
+ D R++ +D QP HL DVNC ++P +A+ S D
Sbjct: 600 FVSGGHDRVARLWA----TDHYQPLRIFAGHL-----ADVNCTRFHPNS-NYVATGSADR 649
Query: 327 EVAFW 331
V W
Sbjct: 650 TVRLW 654
>gi|5803221 WD repeat-containing protein 3 [Homo sapiens]
Length = 943
Score = 85.5 bits (210), Expect = 6e-17
Identities = 65/225 (28%), Positives = 106/225 (47%), Gaps = 16/225 (7%)
Query: 7 LLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTE--GDSWICKSVLSEGHQRTV 64
LL + AH D W ++ +P + G D+ ++ W E D + LS RT+
Sbjct: 488 LLETIDAH-DGALWSMSLSPDQRGFVTGGADKSVKFWDFELVKDENSTQKRLSVKQTRTL 546
Query: 65 RK------VAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
+ V++SP LA + D T I+ D + +L GH+ V + + G
Sbjct: 547 QLDEDVLCVSYSPNQKLLAVSLLDCTVKIFYV--DTLKFFLSLYGHKLPVICMDISHDGA 604
Query: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
L+AT S D++V +W +D D C L +H V ++ + P L +A D +K +
Sbjct: 605 LIATGSADRNVKIWGLDFGD---CHKSLFAHDDSVMYLQFVPKSHLFFTAGKDHKIKQW- 660
Query: 179 EEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQ 223
+ D + TLEGH +W LA PSG + S S D+++R+W +
Sbjct: 661 -DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWER 704
Score = 59.7 bits (143), Expect = 4e-09
Identities = 41/122 (33%), Positives = 65/122 (53%), Gaps = 14/122 (11%)
Query: 28 GTLLASCGGDRRIRIWGTE-GDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDATTC 86
G L+A+ DR ++IWG + GD KS+ + H +V + + P + +A D
Sbjct: 603 GALIATGSADRNVKIWGLDFGDCH--KSLFA--HDDSVMYLQFVPKSHLFFTAGKDHKIK 658
Query: 87 IWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE-------VDEEDE 139
W + D FE + TLEGH E+ +A +PSG+ + + S DKS+ +WE ++EE E
Sbjct: 659 QW--DADKFEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWERTREPLILEEERE 716
Query: 140 YE 141
E
Sbjct: 717 ME 718
Score = 56.6 bits (135), Expect = 3e-08
Identities = 42/169 (24%), Positives = 77/169 (45%), Gaps = 7/169 (4%)
Query: 53 KSVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVA 112
K ++ +G ++ V + SP G +LA D + I+ + T GH+ + ++
Sbjct: 57 KILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGN--VTFNGHKAAITTLK 114
Query: 113 WAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDD 172
+ G LA+ S+D + VW+V E + L H + ++ + LL ++ D
Sbjct: 115 YDQLGGRLASGSKDTDIIVWDVINESG---LYRLKGHKDAITQALFLREKNLLVTSGKDT 171
Query: 173 TVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
VK + + D C T+ GH + VW L +RL + + D +R+W
Sbjct: 172 MVKWW--DLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVW 218
Score = 52.4 bits (124), Expect = 6e-07
Identities = 31/124 (25%), Positives = 60/124 (48%), Gaps = 5/124 (4%)
Query: 59 GHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGN 118
GH+ V + S G +A+ S D IW D +C +L H++ V + + P +
Sbjct: 589 GHKLPVICMDISHDGALIATGSADRNVKIW--GLDFGDCHKSLFAHDDSVMYLQFVPKSH 646
Query: 119 LLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYR 178
L T +D + W+ D+ +E + L H Q++ + PS + + S+S+D +++L+
Sbjct: 647 LFFTAGKDHKIKQWDADK---FEHIQTLEGHHQEIWCLAVSPSGDYVVSSSHDKSLRLWE 703
Query: 179 EEED 182
+
Sbjct: 704 RTRE 707
Score = 37.7 bits (86), Expect = 0.015
Identities = 29/120 (24%), Positives = 49/120 (40%), Gaps = 5/120 (4%)
Query: 22 LAWNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASF 81
L ++ G LAS D I +W +S + + +GH+ + + + N L ++
Sbjct: 113 LKYDQLGGRLASGSKDTDIIVWDVINESGLYRL---KGHKDAITQALFLREKNLLVTSGK 169
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D W + D C T+ GH EV + L T + D + VW++ E E
Sbjct: 170 DTMVKWW--DLDTQHCFKTMVGHRTEVWGLVLLSEEKRLITGASDSELRVWDIAYLQEIE 227
Score = 34.7 bits (78), Expect = 0.13
Identities = 22/93 (23%), Positives = 46/93 (49%), Gaps = 5/93 (5%)
Query: 129 VWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCA 188
V++W++ + ++ + +L Q+V + P LA D +++++ +
Sbjct: 47 VFIWDLRKGEK---ILILQGLKQEVTCLCPSPDGLHLAVGYEDGSIRIFSLLSGEGN--V 101
Query: 189 TLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
T GH++ + +L +D G RLAS S D + +W
Sbjct: 102 TFNGHKAAITTLKYDQLGGRLASGSKDTDIIVW 134
>gi|56243590 WD repeat domain 33 isoform 1 [Homo sapiens]
Length = 1336
Score = 85.5 bits (210), Expect = 6e-17
Identities = 61/209 (29%), Positives = 95/209 (45%), Gaps = 9/209 (4%)
Query: 23 AWNPAGTLLASCGGDRRIRIWGTEGDSWIC-KSVLSEGHQRTVRKVAWSPCGNYLASASF 81
+++P A+C D +RIW D C + + GH V+ V W P + S S
Sbjct: 209 SFSPTDNKFATCSDDGTVRIW----DFLRCHEERILRGHGADVKCVDWHPTKGLVVSGSK 264
Query: 82 DATTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYE 141
D+ I + + + TL H+N V V +GN L T SRD ++++ E
Sbjct: 265 DSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLNLNGNWLLTASRDHLCKLFDIRNLKEE- 323
Query: 142 CVSVLNSHTQDVKHVVWHPSQE-LLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSL 200
+ V H ++ V WHP E L AS D ++ + + V + HE +WSL
Sbjct: 324 -LQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLLFWHVGVEKEVGGMEM-AHEGMIWSL 381
Query: 201 AFDPSGQRLASCSDDRTVRIWRQYLPGNE 229
A+ P G L S S+D T + W + PG++
Sbjct: 382 AWHPLGHILCSGSNDHTSKFWTRNRPGDK 410
Score = 83.2 bits (204), Expect = 3e-16
Identities = 76/326 (23%), Positives = 134/326 (41%), Gaps = 42/326 (12%)
Query: 24 WNPAGTLLASCGGDRRIRIWGTEGDSWICKSVLSEGHQRTVRKVAWSPCGNYLASASFDA 83
W P G L + +W G ++ +++L + H VR + WS ++ +A
Sbjct: 127 WTPEGRRLVTGASSGEFTLWN--GLTFNFETIL-QAHDSPVRAMTWSHNDMWMLTADHGG 183
Query: 84 TTCIWKKNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEDEYECV 143
W+ N ++ V + H+ ++ +++P+ N ATCS D +V +W+ E
Sbjct: 184 YVKYWQSNMNN---VKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEER-- 238
Query: 144 SVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYREEEDDWVCCATLEGHESTVWSLAFD 203
+L H DVK V WHP++ L+ S S D + + ATL H++TV + +
Sbjct: 239 -ILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHAHKNTVMEVKLN 297
Query: 204 PSGQRLASCSDDRTVRIWR---------------------QYLPGNEQGVACSGSDPS-- 240
+G L + S D +++ + P +E A GSD S
Sbjct: 298 LNGNWLLTASRDHLCKLFDIRNLKEELQVFRGHKKEATAVAWHPVHEGLFASGGSDGSLL 357
Query: 241 -W-----KCICTLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQQPTFSL 294
W K + + H I+ +AW L L + D + + + D + ++L
Sbjct: 358 FWHVGVEKEVGGMEMAHEGMIWSLAWHPLGHILCSGSNDHTSKFWTRNRPGDKMRDRYNL 417
Query: 295 TAHLHQAHSQDVNCVAWNPKEPGLLA 320
+L S+D V ++ EP LA
Sbjct: 418 --NLLPGMSED--GVEYDDLEPNSLA 439
Score = 70.5 bits (171), Expect = 2e-12
Identities = 59/250 (23%), Positives = 98/250 (39%), Gaps = 44/250 (17%)
Query: 111 VAWAPSGNLLATCSRDKSVWVWEVDEEDEYECVSVLNSHTQDVKHVVWHPSQELLASASY 170
V W P G L T + +W + ++L +H V+ + W + + +A +
Sbjct: 125 VRWTPEGRRLVTGASSGEFTLWN---GLTFNFETILQAHDSPVRAMTWSHNDMWMLTADH 181
Query: 171 DDTVKLYREEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW-------RQ 223
VK ++ ++ + H+ + +F P+ + A+CSDD TVRIW +
Sbjct: 182 GGYVKYWQSNMNN---VKMFQAHKEAIREASFSPTDNKFATCSDDGTVRIWDFLRCHEER 238
Query: 224 YLPGNEQGVAC-----------SGSDPS------W-----KCICTLSGFHSRTIYDIAWC 261
L G+ V C SGS S W + + TL H T+ ++
Sbjct: 239 ILRGHGADVKCVDWHPTKGLVVSGSKDSQQPIKFWDPKTGQSLATLHA-HKNTVMEVKLN 297
Query: 262 QLTGALATACGDDAIRVFQEDPNSDPQQPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLAS 321
L TA D ++F + Q + + H ++ VAW+P GL AS
Sbjct: 298 LNGNWLLTASRDHLCKLFDIRNLKEELQ--------VFRGHKKEATAVAWHPVHEGLFAS 349
Query: 322 CSDDGEVAFW 331
DG + FW
Sbjct: 350 GGSDGSLLFW 359
Score = 32.0 bits (71), Expect = 0.81
Identities = 24/107 (22%), Positives = 43/107 (40%), Gaps = 15/107 (14%)
Query: 233 ACSGSDPSWKCIC----TLSGFHSRTIYDIAWCQLTGALATACGDDAIRVFQEDPNSDPQ 288
A SG W + T+ H + + W + TA ++ +Q + N+
Sbjct: 138 ASSGEFTLWNGLTFNFETILQAHDSPVRAMTWSHNDMWMLTADHGGYVKYWQSNMNN--- 194
Query: 289 QPTFSLTAHLHQAHSQDVNCVAWNPKEPGLLASCSDDGEVAFWKYQR 335
+ QAH + + +++P + A+CSDDG V W + R
Sbjct: 195 -------VKMFQAHKEAIREASFSPTD-NKFATCSDDGTVRIWDFLR 233
Score = 28.9 bits (63), Expect = 6.9
Identities = 13/35 (37%), Positives = 17/35 (48%), Gaps = 1/35 (2%)
Query: 9 GRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIW 43
G AH + W LAW+P G +L S D + W
Sbjct: 369 GMEMAH-EGMIWSLAWHPLGHILCSGSNDHTSKFW 402
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.448
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,864,756
Number of Sequences: 37866
Number of extensions: 759874
Number of successful extensions: 4859
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 224
Number of HSP's successfully gapped in prelim test: 102
Number of HSP's that attempted gapping in prelim test: 1711
Number of HSP's gapped (non-prelim): 1509
length of query: 339
length of database: 18,247,518
effective HSP length: 103
effective length of query: 236
effective length of database: 14,347,320
effective search space: 3385967520
effective search space used: 3385967520
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.