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Search of human proteins with 46397353
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|46397353 Notch homolog 2 N-terminal like protein [Homo
sapiens]
(236 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens] 546 e-156
gi|24041035 notch 2 preproprotein [Homo sapiens] 489 e-138
gi|148833508 notch1 preproprotein [Homo sapiens] 215 2e-56
gi|134244285 Notch homolog 3 [Homo sapiens] 188 4e-48
gi|55770876 notch4 preproprotein [Homo sapiens] 181 6e-46
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 157 6e-39
gi|122937283 6720455I24Rik homolog [Homo sapiens] 156 1e-38
gi|110735443 delta-like 1 [Homo sapiens] 152 2e-37
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 151 5e-37
gi|4557679 jagged 1 precursor [Homo sapiens] 150 7e-37
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 149 2e-36
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 145 3e-35
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 145 4e-35
gi|148886654 polydom [Homo sapiens] 143 1e-34
gi|112420992 crumbs homolog 2 [Homo sapiens] 141 4e-34
gi|74136023 delta-like 1 homolog [Homo sapiens] 140 1e-33
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 130 8e-31
gi|4759146 slit homolog 2 [Homo sapiens] 130 1e-30
gi|188528675 slit homolog 1 [Homo sapiens] 129 2e-30
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 128 4e-30
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 128 4e-30
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 126 2e-29
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 125 4e-29
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 125 4e-29
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 125 4e-29
gi|11321571 slit homolog 3 [Homo sapiens] 117 7e-27
gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens] 115 3e-26
gi|93102379 low density lipoprotein-related protein 1B precursor... 107 1e-23
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 104 6e-23
gi|126091152 cubilin [Homo sapiens] 102 2e-22
>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
Length = 236
Score = 546 bits (1408), Expect = e-156
Identities = 236/236 (100%), Positives = 236/236 (100%)
Query: 1 MCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
MCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE
Sbjct: 1 MCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC 120
DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC
Sbjct: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC 120
Query: 121 TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD
Sbjct: 121 TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
Query: 181 SLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERDREVWNGKEHDEN 236
SLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERDREVWNGKEHDEN
Sbjct: 181 SLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERDREVWNGKEHDEN 236
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 489 bits (1258), Expect = e-138
Identities = 210/211 (99%), Positives = 210/211 (99%)
Query: 1 MCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
MCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE
Sbjct: 40 MCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 99
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC 120
DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC
Sbjct: 100 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC 159
Query: 121 TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQC QGFTGQYCD
Sbjct: 160 TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCD 219
Query: 181 SLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
SLYVPCAPSPCVNGGTCRQTGDFTFECNCLP
Sbjct: 220 SLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 250
Score = 170 bits (431), Expect = 9e-43
Identities = 84/204 (41%), Positives = 113/204 (55%), Gaps = 8/204 (3%)
Query: 9 TGY-CKCPEGFLGEYCQH-RDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
+GY C C + G+ CQ PC N C+N C TC CA G+ G+ C
Sbjct: 815 SGYTCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDI 874
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 125
+S+PC+N G CH ++ +Y C C GF+G +C+ D CL++PC NG +C N
Sbjct: 875 DE--CISKPCMNHGLCHN-TQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDGVN 931
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
FSC CL GFTG KC+TD+NEC + C++GGTC + SY C+C GF G +C++
Sbjct: 932 TFSCLCLPGFTGDKCQTDMNEC-LSEPCKNGGTCSDYVNSYTCKCQAGFDGVHCENNINE 990
Query: 186 CAPSPCVNGGTCRQTGDFTFECNC 209
C S C NGGTC G +F C C
Sbjct: 991 CTESSCFNGGTC-VDGINSFSCLC 1013
Score = 160 bits (406), Expect = 7e-40
Identities = 86/199 (43%), Positives = 112/199 (56%), Gaps = 12/199 (6%)
Query: 6 HN--GTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC 62
HN G+ C+CP GF G C+ D C N CQNGG+C+ + +C C GFTG+ C
Sbjct: 889 HNTQGSYMCECPPGFSGMDCEEDIDDCLANPCQNGGSCMDG--VNTFSCLCLPGFTGDKC 946
Query: 63 QYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCT 121
Q + + C +S PC NGGTC ++Y C CQ GF G C+ + C C NG TC
Sbjct: 947 Q-TDMNEC-LSEPCKNGGTCSDYV-NSYTCKCQAGFDGVHCENNINECTESSCFNGGTCV 1003
Query: 122 TVANQFSCKCLTGFTGQKCETDVNECDIPGH-CQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
N FSC C GFTG C ++NEC H C + GTC++ G+Y+C C G+TG+ C
Sbjct: 1004 DGINSFSCLCPVGFTGSFCLHEINECS--SHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQ 1061
Query: 181 SLYVPCAPSPCVNGGTCRQ 199
+L C+ SPC N GTC Q
Sbjct: 1062 TLVNLCSRSPCKNKGTCVQ 1080
Score = 160 bits (406), Expect = 7e-40
Identities = 82/218 (37%), Positives = 113/218 (51%), Gaps = 14/218 (6%)
Query: 1 MCVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTG 59
+C+ N T YC+CP G+ G YC+ + D C N CQ+G TC +G C C G+ G
Sbjct: 1125 VCINAGN-THYCQCPLGYTGSYCEEQLDECASNPCQHGATC--SDFIGGYRCECVPGYQG 1181
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHP-CANG 117
+C+Y ++PC NGGTC L ++C+C G G C+ D C P C NG
Sbjct: 1182 VNCEYEVDE--CQNQPCQNGGTCIDLVNH-FKCSCPPGTRGLLCEENIDDCARGPHCLNG 1238
Query: 118 STCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGT--CLNLPGSYQCQCLQGFT 175
C +SC+CL GF G++CE D+NEC + C G+ C+ L Y C C FT
Sbjct: 1239 GQCMDRIGGYSCRCLPGFAGERCEGDINEC-LSNPCSSEGSLDCIQLTNDYLCVCRSAFT 1297
Query: 176 GQYCDSLYVPCAPSPCVNGGTCRQTGDFT--FECNCLP 211
G++C++ C PC+NGGTC + F C C P
Sbjct: 1298 GRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPP 1335
Score = 159 bits (402), Expect = 2e-39
Identities = 86/212 (40%), Positives = 111/212 (52%), Gaps = 10/212 (4%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCE-KNRCQNGGTCVAQAMLGKATCRCASGFTG 59
C T N CKC GF G+ C+ + C+ CQ+GGTC+ + G C+C GFTG
Sbjct: 159 CTTVANQFS-CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLN--LPGSYQCQCPQGFTG 215
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGS 118
+ C S PC S PC+NGGTC T+EC C GF G C+ D C +H C NG
Sbjct: 216 QYCD-SLYVPCAPS-PCVNGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNHRCQNGG 273
Query: 119 TCTTVANQFSCKCLTGFTGQKCETDVNECDI-PGHCQHGGTCLNLPGSYQCQCLQGFTGQ 177
C N ++C+C +TGQ C DV+EC + P CQ+GGTC N G Y C C+ G++G
Sbjct: 274 VCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGD 333
Query: 178 YCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
C CA + C G TC +F C C
Sbjct: 334 DCSENIDDCAFASCTPGSTCIDR-VASFSCMC 364
Score = 147 bits (372), Expect = 6e-36
Identities = 78/209 (37%), Positives = 108/209 (51%), Gaps = 10/209 (4%)
Query: 7 NGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYS 65
+G +C+C +G+ G C+ + C + CQN TC+ + +G TC C GF G C+
Sbjct: 437 DGAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDK--IGGFTCLCMPGFKGVHCELE 494
Query: 66 TSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVA 124
+ S PC+N G C + + ++C C GFTG CQ D C S PC NG+ C
Sbjct: 495 INE--CQSNPCVNNGQC-VDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHP 551
Query: 125 NQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYV 184
N + C+C TGFTG CE +++ CD P C H G C + SY C C G+ G C
Sbjct: 552 NGYECQCATGFTGVLCEENIDNCD-PDPCHH-GQCQDGIDSYTCICNPGYMGAICSDQID 609
Query: 185 PCAPSPCVNGGTCRQTGDFTFECNCLPET 213
C SPC+N G C + ++CNC P T
Sbjct: 610 ECYSSPCLNDGRCIDLVN-GYQCNCQPGT 637
Score = 147 bits (370), Expect = 1e-35
Identities = 81/220 (36%), Positives = 115/220 (52%), Gaps = 18/220 (8%)
Query: 1 MCVTYHNGTGYCKCPEGFLGEYC-QHRDPC--EKNRCQNGGTCVAQAMLGKATCRCASGF 57
+CV N T C+CP + G++C + D C + N CQNGGTC + G C C +G+
Sbjct: 274 VCVDGVN-TYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRN--GGYGCVCVNGW 330
Query: 58 TGEDCQYSTSHPCFVSRPCLNGGTCHMLSR-DTYECTCQVGFTGKECQWTDACLSHPCAN 116
+G+DC + F S C G TC + R ++ C C G G C DAC+S+PC
Sbjct: 331 SGDDCSENIDDCAFAS--CTPGSTC--IDRVASFSCMCPEGKAGLLCHLDDACISNPCHK 386
Query: 117 GSTCTT--VANQFSCKCLTGFTGQKCETDVNECDIPGH--CQHGGTCLNLPGSYQCQCLQ 172
G+ C T + Q+ C C G+ G C DV+EC + C+H G C+N G++ C+CL+
Sbjct: 387 GALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLK 446
Query: 173 GFTGQYCDSLYVPCAPSPCVNGGTC-RQTGDFTFECNCLP 211
G+ G C+ C PC N TC + G FT C C+P
Sbjct: 447 GYAGPRCEMDINECHSDPCQNDATCLDKIGGFT--CLCMP 484
Score = 143 bits (361), Expect = 1e-34
Identities = 71/203 (34%), Positives = 105/203 (51%), Gaps = 10/203 (4%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C C GF G+ C D C N C+ G TC+ + C C G C YS + C
Sbjct: 668 CVCSPGFTGQRCNIDIDECASNPCRKGATCING--VNGFRCICPEGPHHPSC-YSQVNEC 724
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSC 129
+S PC++G LS Y+C C G+ G C+ + CLS+PC NG TC + N + C
Sbjct: 725 -LSNPCIHGNCTGGLSG--YKCLCDAGWVGINCEVDKNECLSNPCQNGGTCDNLVNGYRC 781
Query: 130 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPS 189
C GF G C+ +++EC C + GTC + Y C C+ +TG+ C ++ PC+P+
Sbjct: 782 TCKKGFKGYNCQVNIDEC-ASNPCLNQGTCFDDISGYTCHCVLPYTGKNCQTVLAPCSPN 840
Query: 190 PCVNGGTCRQTGDF-TFECNCLP 211
PC N C+++ +F ++ C C P
Sbjct: 841 PCENAAVCKESPNFESYTCLCAP 863
Score = 135 bits (341), Expect = 2e-32
Identities = 70/211 (33%), Positives = 98/211 (46%), Gaps = 20/211 (9%)
Query: 12 CKCPEGFLGEYCQ-----------HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
C CP G+ G YC R ++ CQ+ G C+ C+C G+TG
Sbjct: 1087 CLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAG--NTHYCQCPLGYTGS 1144
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGST 119
C+ S PC +G TC Y C C G+ G C++ D C + PC NG T
Sbjct: 1145 YCEEQLDE--CASNPCQHGATCSDFIGG-YRCECVPGYQGVNCEYEVDECQNQPCQNGGT 1201
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
C + N F C C G G CE ++++C HC +GG C++ G Y C+CL GF G+ C
Sbjct: 1202 CIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDRIGGYSCRCLPGFAGERC 1261
Query: 180 DSLYVPCAPSPCVNGGT--CRQ-TGDFTFEC 207
+ C +PC + G+ C Q T D+ C
Sbjct: 1262 EGDINECLSNPCSSEGSLDCIQLTNDYLCVC 1292
Score = 134 bits (338), Expect = 5e-32
Identities = 76/210 (36%), Positives = 100/210 (47%), Gaps = 19/210 (9%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C C GF G+ CQ + C C+NGGTC + TC+C +GF G C+ + + C
Sbjct: 935 CLCLPGFTGDKCQTDMNECLSEPCKNGGTC--SDYVNSYTCKCQAGFDGVHCENNINE-C 991
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFSC 129
S C NGGTC + +++ C C VGFTG C + C SHPC N TC + C
Sbjct: 992 TESS-CFNGGTC-VDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRC 1049
Query: 130 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPC--- 186
C G+TG+ C+T VN C C++ GTC+ QC C G+ G YCD V C
Sbjct: 1050 SCPLGYTGKNCQTLVNLCS-RSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIA 1108
Query: 187 -------APSPCVNGGTCRQTGDFTFECNC 209
C + G C G+ T C C
Sbjct: 1109 ASRRGVLVEHLCQHSGVCINAGN-THYCQC 1137
Score = 128 bits (321), Expect = 5e-30
Identities = 77/216 (35%), Positives = 106/216 (49%), Gaps = 15/216 (6%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
C+ NG C C G G C+ + D C N C +G + + + +C C+ GFTG+
Sbjct: 622 CIDLVNGY-QCNCQPGTSGVNCEINFDDCASNPCIHG---ICMDGINRYSCVCSPGFTGQ 677
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGST 119
C S PC G TC + + + C C G C + CLS+PC +G+
Sbjct: 678 RCNIDIDE--CASNPCRKGATC-INGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGN- 733
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
CT + + C C G+ G CE D NEC + CQ+GGTC NL Y+C C +GF G C
Sbjct: 734 CTGGLSGYKCLCDAGWVGINCEVDKNEC-LSNPCQNGGTCDNLVNGYRCTCKKGFKGYNC 792
Query: 180 DSLYVPCAPSPCVNGGTCRQTGDFT-FECNC-LPET 213
CA +PC+N GTC D + + C+C LP T
Sbjct: 793 QVNIDECASNPCLNQGTC--FDDISGYTCHCVLPYT 826
Score = 106 bits (264), Expect = 2e-23
Identities = 54/140 (38%), Positives = 70/140 (50%), Gaps = 6/140 (4%)
Query: 75 PCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVA--NQFSCKCL 132
PC+N G C T C C GF G+ CQ D C + C NG TC A + +C+C
Sbjct: 34 PCVNEGMCVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCA 93
Query: 133 TGFTGQKCETDVNE-CDIPGHCQHGGTCLNLP-GSYQCQCLQGFTGQYCDSLYVPCAPSP 190
+GFTG+ C+ + C + C +GGTC L +Y+C C GFTG+ C C P
Sbjct: 94 SGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDA-CLSHP 152
Query: 191 CVNGGTCRQTGDFTFECNCL 210
C NG TC + F C CL
Sbjct: 153 CANGSTCTTVAN-QFSCKCL 171
Score = 72.4 bits (176), Expect = 3e-13
Identities = 59/196 (30%), Positives = 80/196 (40%), Gaps = 29/196 (14%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTC-VAQAMLGKATCRCASGFTGEDCQYSTSHP 69
C C F G +C+ D C + C NGGTC VA M CRC GF+G CQ S
Sbjct: 1290 CVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQSSCGQV 1349
Query: 70 CFVSRPCLNGGTC-HMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVAN--Q 126
C G C H S C C + ++C+ C S PC +G +C
Sbjct: 1350 -----KCRKGEQCVHTASGP--RCFCP---SPRDCE--SGCASSPCQHGGSCHPQRQPPY 1397
Query: 127 FSCKCLTGFTGQKCE-------TDVNECDIPGHC---QHGGTCLNLPGSYQCQCLQGFTG 176
+SC+C F+G +CE T C + +C G C S+ CQ G
Sbjct: 1398 YSCQCAPPFSGSRCELYTAPPSTPPATC-LSQYCADKARDGVCDEACNSHACQWDGGDCS 1456
Query: 177 QYCDSLYVPC-APSPC 191
++ + C +P PC
Sbjct: 1457 LTMENPWANCSSPLPC 1472
Score = 52.8 bits (125), Expect = 3e-07
Identities = 48/203 (23%), Positives = 68/203 (33%), Gaps = 48/203 (23%)
Query: 12 CKCPEGFLGEYCQH------------------------------RDPCEKNRCQNGGTCV 41
C+CP GF G CQ C + CQ+GG+C
Sbjct: 1331 CRCPPGFSGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCH 1390
Query: 42 AQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGK 101
Q +C+CA F+G C+ T+ P CL+ C +RD C
Sbjct: 1391 PQRQPPYYSCQCAPPFSGSRCELYTAPPSTPPATCLS-QYCADKARDG---VCDEACNSH 1446
Query: 102 ECQW----TDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGG 157
CQW + +P AN S+ + + +C +C D EC +
Sbjct: 1447 ACQWDGGDCSLTMENPWANCSSPLPCWDYINNQCDELCNTVECLFDNFECQ-----GNSK 1501
Query: 158 TCLNLPGSYQCQCLQGFTGQYCD 180
TC Y C F +CD
Sbjct: 1502 TC-----KYDKYCADHFKDNHCD 1519
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 215 bits (548), Expect = 2e-56
Identities = 101/208 (48%), Positives = 119/208 (57%), Gaps = 4/208 (1%)
Query: 7 NGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKA--TCRCASGFTGEDCQY 64
NGT C C F+G CQ +PC C+N GTC G A C CA GF+G C
Sbjct: 41 NGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLT 100
Query: 65 STSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVA 124
+ C ++ PC NGGTC +L+ Y+C C G++GK CQ D C S+PCANG C
Sbjct: 101 PLDNAC-LTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFE 159
Query: 125 NQFSCKCLTGFTGQKCETDVNEC-DIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLY 183
+ C C F G C DVNEC PG C+HGGTC N GSY+C C TG C+ Y
Sbjct: 160 ASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPY 219
Query: 184 VPCAPSPCVNGGTCRQTGDFTFECNCLP 211
VPC+PSPC NGGTCR TGD T EC CLP
Sbjct: 220 VPCSPSPCQNGGTCRPTGDVTHECACLP 247
Score = 169 bits (427), Expect = 2e-42
Identities = 83/211 (39%), Positives = 113/211 (53%), Gaps = 23/211 (10%)
Query: 12 CKCPEGFLGEYCQHRDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C CP GF G +C++ P C ++ C NGGTCV + TC C GFTG CQ+ +
Sbjct: 969 CTCPAGFSGIHCENNTPDCTESSCFNGGTCVDG--INSFTCLCPPGFTGSYCQHDVNE-- 1024
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ----WTDACLSHPCANGSTCTTVANQ 126
S+PCL+GGTC +Y CTC G+TG CQ W D S PC NG C Q
Sbjct: 1025 CDSQPCLHGGTCQD-GCGSYRCTCPQGYTGPNCQNLVHWCD---SSPCKNGGKCWQTHTQ 1080
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGH---------CQHGGTCLNLPGSYQCQCLQGFTGQ 177
+ C+C +G+TG C+ C++ CQHGG C++ ++ C+C G+TG
Sbjct: 1081 YRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGS 1140
Query: 178 YCDSLYVPCAPSPCVNGGTCRQ-TGDFTFEC 207
YC+ L C+PSPC NG TC G ++ +C
Sbjct: 1141 YCEDLVDECSPSPCQNGATCTDYLGGYSCKC 1171
Score = 167 bits (424), Expect = 6e-42
Identities = 87/207 (42%), Positives = 114/207 (55%), Gaps = 14/207 (6%)
Query: 12 CKCPEGFLGEYC-QHRDPCE--KNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSH 68
C+CP + G+YC + D C+ N CQNGGTC G C C +G+TGEDC +
Sbjct: 281 CRCPPEWTGQYCTEDVDECQLMPNACQNGGTC--HNTHGGYNCVCVNGWTGEDCSENIDD 338
Query: 69 PCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTT--VANQ 126
S C +G TCH Y C C G TG C DAC+S+PC GS C T V +
Sbjct: 339 --CASAACFHGATCHDRVASFY-CECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGK 395
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGH-CQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
C C +G+TG C DV+EC + + C+H G C+N GS++CQCLQG+TG C+
Sbjct: 396 AICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNE 455
Query: 186 CAPSPCVNGGTC-RQTGDFTFECNCLP 211
C +PC N TC Q G+ F+C C+P
Sbjct: 456 CVSNPCQNDATCLDQIGE--FQCICMP 480
Score = 161 bits (408), Expect = 4e-40
Identities = 85/207 (41%), Positives = 113/207 (54%), Gaps = 12/207 (5%)
Query: 10 GY-CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
GY C C G+ G C + + CE N C NGGTC + M C C GF+G +CQ + +
Sbjct: 736 GYKCDCDPGWSGTNCDINNNECESNPCVNGGTC--KDMTSGYVCTCREGFSGPNCQTNIN 793
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDA-CLSHPCANGSTCTTVAN- 125
S PCLN GTC + Y+C C + +TG C+ A C PC NG C +
Sbjct: 794 E--CASNPCLNQGTC-IDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDY 850
Query: 126 -QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYV 184
FSC C TG+ GQ CE D+NEC + C+HG +C N G Y+C C G++G+ C++
Sbjct: 851 ESFSCVCPTGWQGQTCEVDINEC-VLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDID 909
Query: 185 PCAPSPCVNGGTCRQTGDFTFECNCLP 211
C P+PC NGG+C G T C+CLP
Sbjct: 910 DCRPNPCHNGGSCTD-GINTAFCDCLP 935
Score = 159 bits (402), Expect = 2e-39
Identities = 74/200 (37%), Positives = 99/200 (49%), Gaps = 4/200 (2%)
Query: 11 YCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
YC+CP G G C D C N C G C + GKA C C SG+TG C
Sbjct: 358 YCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECS 417
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFSC 129
+ PC + G C + + ++EC C G+TG C+ + C+S+PC N +TC +F C
Sbjct: 418 LGANPCEHAGKC-INTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQC 476
Query: 130 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPS 189
C+ G+ G CE + +EC C H G CL+ +QC+C GFTG C CA +
Sbjct: 477 ICMPGYEGVHCEVNTDEC-ASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECAST 535
Query: 190 PCVNGGTCRQTGDFTFECNC 209
PC NG C G T+ C C
Sbjct: 536 PCKNGAKCLD-GPNTYTCVC 554
Score = 159 bits (401), Expect = 3e-39
Identities = 81/204 (39%), Positives = 112/204 (54%), Gaps = 11/204 (5%)
Query: 10 GY-CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
GY C C G+ G C + D C N C NGGTC + + TCRC G+ C S
Sbjct: 661 GYECACEPGYTGSMCNINIDECAGNPCHNGGTC--EDGINGFTCRCPEGYHDPTC-LSEV 717
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANGSTCTTVANQ 126
+ C S PC++G L+ Y+C C G++G C + C S+PC NG TC + +
Sbjct: 718 NECN-SNPCVHGACRDSLNG--YKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSG 774
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPC 186
+ C C GF+G C+T++NEC C + GTC++ Y+C CL +TG C+ + PC
Sbjct: 775 YVCTCREGFSGPNCQTNINEC-ASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPC 833
Query: 187 APSPCVNGGTCRQTGDF-TFECNC 209
APSPC NGG CRQ+ D+ +F C C
Sbjct: 834 APSPCRNGGECRQSEDYESFSCVC 857
Score = 157 bits (397), Expect = 8e-39
Identities = 83/237 (35%), Positives = 108/237 (45%), Gaps = 43/237 (18%)
Query: 12 CKCPEGFLGEYCQHRDPCEKNRCQNGGTCV------------------------------ 41
C+CP G+ G+ CQ DPC N C NGG C+
Sbjct: 127 CRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKP 186
Query: 42 --------AQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECT 93
+G C C + TG +C+ PC S PC NGGTC T+EC
Sbjct: 187 GLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYV-PCSPS-PCQNGGTCRPTGDVTHECA 244
Query: 94 CQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDI-PG 151
C GFTG+ C+ D C + C NG C N ++C+C +TGQ C DV+EC + P
Sbjct: 245 CLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPN 304
Query: 152 HCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCR-QTGDFTFEC 207
CQ+GGTC N G Y C C+ G+TG+ C CA + C +G TC + F EC
Sbjct: 305 ACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCEC 361
Score = 157 bits (397), Expect = 8e-39
Identities = 80/215 (37%), Positives = 116/215 (53%), Gaps = 10/215 (4%)
Query: 8 GTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
G+ C+C +G+ G C+ + C N CQN TC+ Q +G+ C C G+ G C+ +T
Sbjct: 434 GSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQ--IGEFQCICMPGYEGVHCEVNT 491
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVAN 125
S PCL+ G C + + ++C C GFTG CQ+ D C S PC NG+ C N
Sbjct: 492 DE--CASSPCLHNGRC-LDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPN 548
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
++C C G+TG CE D++ECD P C H G+C + ++ C C G+TG +C++
Sbjct: 549 TYTCVCTEGYTGTHCEVDIDECD-PDPC-HYGSCKDGVATFTCLCRPGYTGHHCETNINE 606
Query: 186 CAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTEL 220
C+ PC +GGTC Q D + C CL T E+
Sbjct: 607 CSSQPCRHGGTC-QDRDNAYLCFCLKGTTGPNCEI 640
Score = 155 bits (391), Expect = 4e-38
Identities = 80/209 (38%), Positives = 109/209 (52%), Gaps = 12/209 (5%)
Query: 7 NGTGYCKCPEGFLGEYC-QHRDPCE--KNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ 63
NG C CP G+ G C Q D C N C++ G C+ LG C+C G+TG C+
Sbjct: 393 NGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCI--NTLGSFECQCLQGYTGPRCE 450
Query: 64 YSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTT 122
+ VS PC N TC + ++C C G+ G C+ TD C S PC + C
Sbjct: 451 IDVNE--CVSNPCQNDATC-LDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLD 507
Query: 123 VANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSL 182
N+F C+C TGFTG C+ DV+EC C++G CL+ P +Y C C +G+TG +C+
Sbjct: 508 KINEFQCECPTGFTGHLCQYDVDEC-ASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVD 566
Query: 183 YVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C P PC + G+C+ G TF C C P
Sbjct: 567 IDECDPDPC-HYGSCKD-GVATFTCLCRP 593
Score = 149 bits (375), Expect = 3e-36
Identities = 83/223 (37%), Positives = 110/223 (49%), Gaps = 21/223 (9%)
Query: 1 MCVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTG 59
+CV N T +C+C G+ G YC+ D C + CQNG TC LG +C+C +G+ G
Sbjct: 1121 LCVDAGN-THHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDY--LGGYSCKCVAGYHG 1177
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DAC--------L 110
+C +S PC NGGTC L +TY+C+C G G C+ D C
Sbjct: 1178 VNCSEEIDE--CLSHPCQNGGTCLDLP-NTYKCSCPRGTQGVHCEINVDDCNPPVDPVSR 1234
Query: 111 SHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGT--CLNLPGSYQC 168
S C N TC +SC C GF G++CE DVNEC + C GT C+ + C
Sbjct: 1235 SPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNEC-LSNPCDARGTQNCVQRVNDFHC 1293
Query: 169 QCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFT--FECNC 209
+C G TG+ C+S+ C PC NGGTC + F C C
Sbjct: 1294 ECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKC 1336
Score = 148 bits (374), Expect = 3e-36
Identities = 82/223 (36%), Positives = 117/223 (52%), Gaps = 25/223 (11%)
Query: 8 GTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQY-- 64
G+ C CP+G+ G CQ+ C+ + C+NGG C + C C SG+TG C
Sbjct: 1041 GSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHT--QYRCECPSGWTGLYCDVPS 1098
Query: 65 ------STSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-WTDACLSHPCANG 117
+ V+R C +GG C + + +T+ C CQ G+TG C+ D C PC NG
Sbjct: 1099 VSCEVAAQRQGVDVARLCQHGGLC-VDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNG 1157
Query: 118 STCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQ 177
+TCT +SCKC+ G+ G C +++EC + CQ+GGTCL+LP +Y+C C +G G
Sbjct: 1158 ATCTDYLGGYSCKCVAGYHGVNCSEEIDEC-LSHPCQNGGTCLDLPNTYKCSCPRGTQGV 1216
Query: 178 YCDSLYVPCAP-------SP-CVNGGTC-RQTGDFTFECNCLP 211
+C+ C P SP C N GTC Q G ++ C C P
Sbjct: 1217 HCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYS--CTCPP 1257
Score = 144 bits (363), Expect = 7e-35
Identities = 76/205 (37%), Positives = 105/205 (51%), Gaps = 8/205 (3%)
Query: 10 GY-CKCPEGFLGEYCQH-RDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
GY C C + G C+ PC + C+NGG C +C C +G+ G+ C+ +
Sbjct: 812 GYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDIN 871
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQ 126
C +S PC +G +C + Y C CQ G++G+ C+ D C +PC NG +CT N
Sbjct: 872 E-CVLS-PCRHGASCQN-THGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINT 928
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPC 186
C CL GF G CE D+NEC C++G C + SY C C GF+G +C++ C
Sbjct: 929 AFCDCLPGFRGTFCEEDINEC-ASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDC 987
Query: 187 APSPCVNGGTCRQTGDFTFECNCLP 211
S C NGGTC G +F C C P
Sbjct: 988 TESSCFNGGTC-VDGINSFTCLCPP 1011
Score = 136 bits (342), Expect = 2e-32
Identities = 74/204 (36%), Positives = 98/204 (48%), Gaps = 19/204 (9%)
Query: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSH-- 68
C+CP GF G CQ+ D C C+NG C+ TC C G+TG C+
Sbjct: 514 CECPTGFTGHLCQYDVDECASTPCKNGAKCLDGP--NTYTCVCTEGYTGTHCEVDIDECD 571
Query: 69 --PCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 125
PC C +G T+ C C+ G+TG C+ + C S PC +G TC N
Sbjct: 572 PDPCHYGS-CKDGVA-------TFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDN 623
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
+ C CL G TG CE ++++C C GTCL+ Y+C C G+TG C+
Sbjct: 624 AYLCFCLKGTTGPNCEINLDDC-ASSPCD-SGTCLDKIDGYECACEPGYTGSMCNINIDE 681
Query: 186 CAPSPCVNGGTCRQTGDFTFECNC 209
CA +PC NGGTC + G F C C
Sbjct: 682 CAGNPCHNGGTC-EDGINGFTCRC 704
Score = 134 bits (337), Expect = 7e-32
Identities = 77/218 (35%), Positives = 100/218 (45%), Gaps = 27/218 (12%)
Query: 12 CKCPEGFLGEYC-----------QHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
C+CP G+ G YC Q + CQ+GG CV CRC +G+TG
Sbjct: 1083 CECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAG--NTHHCRCQAGYTGS 1140
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGST 119
C+ C S PC NG TC Y C C G+ G C + D CLSHPC NG T
Sbjct: 1141 YCEDLVDE-CSPS-PCQNGATCTDYLGG-YSCKCVAGYHGVNCSEEIDECLSHPCQNGGT 1197
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIP-------GHCQHGGTCLNLPGSYQCQCLQ 172
C + N + C C G G CE +V++C+ P C + GTC++ G Y C C
Sbjct: 1198 CLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPP 1257
Query: 173 GFTGQYCDSLYVPCAPSPCVNGGT---CRQTGDFTFEC 207
GF G+ C+ C +PC GT ++ DF EC
Sbjct: 1258 GFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCEC 1295
Score = 89.0 bits (219), Expect = 3e-18
Identities = 67/223 (30%), Positives = 88/223 (39%), Gaps = 49/223 (21%)
Query: 12 CKCPEGFLGEYCQH-RDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
CKCP GF G C++ C RC NGGTC++ TC C FTG +CQ+ S PC
Sbjct: 1334 CKCPAGFEGATCENDARTCGSLRCLNGGTCISGPR--SPTCLCLGPFTGPECQFPASSPC 1391
Query: 71 FVSRPCLNGGTCHMLSRDT-YECTCQVGFTGKECQWTD------------------ACLS 111
PC N GTC S Y C C F G C D AC
Sbjct: 1392 LGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACEL 1451
Query: 112 HPC---ANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQC 168
C A C+ N +C G+ G C + N D +C +
Sbjct: 1452 PECQEDAGNKVCSLQCNNHAC----GWDGGDCSLNFN--DPWKNC-----------TQSL 1494
Query: 169 QCLQGFTGQYCDSLYVPCAPSPCV-NGGTCRQTGDFTFECNCL 210
QC + F+ +CDS C + C+ +G C++ +CN L
Sbjct: 1495 QCWKYFSDGHCDS---QCNSAGCLFDGFDCQRAEG---QCNPL 1531
Score = 63.2 bits (152), Expect = 2e-10
Identities = 35/103 (33%), Positives = 46/103 (44%), Gaps = 7/103 (6%)
Query: 114 CANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLP----GSYQCQ 169
C NG C +C C F G +C+ D N C + C++ GTC + Y C
Sbjct: 31 CLNGGKCEAANGTEACVCGGAFVGPRCQ-DPNPC-LSTPCKNAGTCHVVDRRGVADYACS 88
Query: 170 CLQGFTGQYC-DSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C GF+G C L C +PC NGGTC ++C C P
Sbjct: 89 CALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPP 131
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 188 bits (477), Expect = 4e-48
Identities = 88/189 (46%), Positives = 114/189 (60%), Gaps = 9/189 (4%)
Query: 28 PC-EKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCH--- 83
PC + + C NGG C Q +A C C G+ GE CQ PC S PC G C
Sbjct: 42 PCLDGSPCANGGRCT-QLPSREAACLCPPGWVGERCQLED--PCH-SGPCAGRGVCQSSV 97
Query: 84 MLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVAN-QFSCKCLTGFTGQKCET 142
+ + C C GF G +C D CLS PCA+G+ C+ + +F C C G+ G+ C +
Sbjct: 98 VAGTARFSCRCPRGFRGPDCSLPDPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRS 157
Query: 143 DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGD 202
DV+EC + C+HGGTCLN PGS++CQC G+TG C++ VPCAPSPC NGGTCRQ+GD
Sbjct: 158 DVDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGD 217
Query: 203 FTFECNCLP 211
T++C CLP
Sbjct: 218 LTYDCACLP 226
Score = 161 bits (407), Expect = 5e-40
Identities = 82/212 (38%), Positives = 111/212 (52%), Gaps = 9/212 (4%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNR-CQNGGTCVAQAMLGKATCRCASGFTG 59
C +G C CP G+ G C+ D C C++GGTC+ G C+C +G+TG
Sbjct: 134 CSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTP--GSFRCQCPAGYTG 191
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGS 118
C+ + + PC S PC NGGTC TY+C C GF G+ C+ D C H C NG
Sbjct: 192 PLCE-NPAVPCAPS-PCRNGGTCRQSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGG 249
Query: 119 TCTTVANQFSCKCLTGFTGQKCETDVNECDI-PGHCQHGGTCLNLPGSYQCQCLQGFTGQ 177
TC N ++C+C +TGQ C DV+EC + P C +GGTC N G + C C+ G+TG+
Sbjct: 250 TCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGE 309
Query: 178 YCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
C CA + C +G TC +F C C
Sbjct: 310 SCSQNIDDCATAVCFHGATCHDR-VASFYCAC 340
Score = 159 bits (401), Expect = 3e-39
Identities = 82/216 (37%), Positives = 106/216 (49%), Gaps = 10/216 (4%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKA--TCRCASGFTG 59
C + C CP G++GE CQ DPC C G C + + G A +CRC GF G
Sbjct: 55 CTQLPSREAACLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRG 114
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDAC-LSHPCANG 117
DC S PC +S PC +G C + + C+C G+ G+ C+ D C + PC +G
Sbjct: 115 PDC--SLPDPC-LSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHG 171
Query: 118 STCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPG-SYQCQCLQGFTG 176
TC F C+C G+TG CE C P C++GGTC +Y C CL GF G
Sbjct: 172 GTCLNTPGSFRCQCPAGYTGPLCENPAVPC-APSPCRNGGTCRQSGDLTYDCACLPGFEG 230
Query: 177 QYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPE 212
Q C+ C C+NGGTC G T+ C C PE
Sbjct: 231 QNCEVNVDDCPGHRCLNGGTC-VDGVNTYNCQCPPE 265
Score = 152 bits (384), Expect = 2e-37
Identities = 79/212 (37%), Positives = 103/212 (48%), Gaps = 8/212 (3%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYC-QHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
CV NG C CP G L C PC C +G + G C C G++G
Sbjct: 672 CVDGENGFR-CLCPPGSLPPLCLPPSHPCAHEPCSHG---ICYDAPGGFRCVCEPGWSGP 727
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC 120
C S + S+PC GGTC + CTC G G++C+ C +PC +G C
Sbjct: 728 RCSQSLARDACESQPCRAGGTCSSDGMG-FHCTCPPGVQGRQCELLSPCTPNPCEHGGRC 786
Query: 121 TTVANQFS-CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
+ Q C C G+ G +C+ DV+EC P C G C NL GS+ C C G+TG C
Sbjct: 787 ESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSC 846
Query: 180 DSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
D C P+PC+NGG+C Q G +F C+CLP
Sbjct: 847 DQDINDCDPNPCLNGGSC-QDGVGSFSCSCLP 877
Score = 151 bits (382), Expect = 4e-37
Identities = 83/210 (39%), Positives = 106/210 (50%), Gaps = 14/210 (6%)
Query: 7 NGTGYCKCPEGFLGEYC-QHRDPCE--KNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ 63
NG C CP GF G C Q D C N C++ G CV G C+C G+TG C+
Sbjct: 372 NGRAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQ--GSFLCQCGRGYTGPRCE 429
Query: 64 YSTSHPCFVSRPCLNGGTCHMLSR-DTYECTCQVGFTGKECQWT-DACLSHPCANGSTCT 121
+ +S PC N TC L R + C C GFTG C+ D C S PC NG C
Sbjct: 430 TDVNE--CLSGPCRNQATC--LDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCK 485
Query: 122 TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDS 181
N FSC C +GF+G C+ DV+EC C++G C++ P Y+C+C +GF G CD
Sbjct: 486 DRVNGFSCTCPSGFSGSTCQLDVDEC-ASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDR 544
Query: 182 LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C+P PC + G C G +F C C P
Sbjct: 545 NVDDCSPDPC-HHGRC-VDGIASFSCACAP 572
Score = 150 bits (379), Expect = 9e-37
Identities = 73/200 (36%), Positives = 96/200 (48%), Gaps = 4/200 (2%)
Query: 11 YCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
YC CP G G C D C N C C + G+A C C GFTG C
Sbjct: 337 YCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECS 396
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFSC 129
+ PC + G C + ++ ++ C C G+TG C+ + CLS PC N +TC QF+C
Sbjct: 397 IGANPCEHLGRC-VNTQGSFLCQCGRGYTGPRCETDVNECLSGPCRNQATCLDRIGQFTC 455
Query: 130 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPS 189
C+ GFTG CE D++EC C +GG C + + C C GF+G C CA +
Sbjct: 456 ICMAGFTGTYCEVDIDECQ-SSPCVNGGVCKDRVNGFSCTCPSGFSGSTCQLDVDECAST 514
Query: 190 PCVNGGTCRQTGDFTFECNC 209
PC NG C D +EC C
Sbjct: 515 PCRNGAKCVDQPD-GYECRC 533
Score = 149 bits (375), Expect = 3e-36
Identities = 79/215 (36%), Positives = 109/215 (50%), Gaps = 22/215 (10%)
Query: 11 YCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
YC CPEG G +C+ DPC CQ+GGTC + +G C C G+ G++C+
Sbjct: 1069 YCVCPEGRTGSHCEQEVDPCLAQPCQHGGTC--RGYMGGYMCECLPGYNGDNCEDDVDE- 1125
Query: 70 CFVSRPCLNGGTC-HMLSRDTYECTCQVGFTGKECQWT-DACLSHP-------CANGSTC 120
S+PC +GG+C +++R Y C+C G G C+ D C P C + TC
Sbjct: 1126 -CASQPCQHGGSCIDLVAR--YLCSCPPGTLGVLCEINEDDCGPGPPLDSGPRCLHNGTC 1182
Query: 121 TTVANQFSCKCLTGFTGQKCETDVNECDIPG-HCQHGGTCLNLP-GSYQCQCLQGFTGQY 178
+ F C C G+TG +CE D+NEC H H CL P G ++C C GF+G
Sbjct: 1183 VDLVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPR 1242
Query: 179 CDSLYVPCAPSPCVNGGTCRQT----GDFTFECNC 209
C ++ PC PC +GG CR + G TF C+C
Sbjct: 1243 CQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHC 1277
Score = 148 bits (373), Expect = 5e-36
Identities = 83/243 (34%), Positives = 111/243 (45%), Gaps = 52/243 (21%)
Query: 12 CKCPEGFLGEYC-QHRDPCE--KNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSH 68
C+CP + G++C + D C+ N C NGGTC LG +C C +G+TGE C +
Sbjct: 260 CQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNT--LGGHSCVCVNGWTGESCSQNIDD 317
Query: 69 PCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTT------ 122
+ C +G TCH Y C C +G TG C DAC+S+PC + C T
Sbjct: 318 --CATAVCFHGATCHDRVASFY-CACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGR 374
Query: 123 ------------------------------------VANQFSCKCLTGFTGQKCETDVNE 146
F C+C G+TG +CETDVNE
Sbjct: 375 AICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVNE 434
Query: 147 CDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFE 206
C + G C++ TCL+ G + C C+ GFTG YC+ C SPCVNGG C+ + F
Sbjct: 435 C-LSGPCRNQATCLDRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVN-GFS 492
Query: 207 CNC 209
C C
Sbjct: 493 CTC 495
Score = 144 bits (362), Expect = 9e-35
Identities = 82/220 (37%), Positives = 110/220 (50%), Gaps = 21/220 (9%)
Query: 4 TYHNGTGYCKCPEGFLGEYCQHRDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC 62
T H + C CP G+ G +C+ P C + C NGGTCV + +C C G+TG C
Sbjct: 902 TDHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDG--VNSFSCLCRPGYTGAHC 959
Query: 63 QYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-WTDACLSHPCANGSTCT 121
Q+ + PC +SRPCL+GG C + + CTC FTG +CQ D C PC NG C
Sbjct: 960 QHE-ADPC-LSRPCLHGGVC-SAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQNGGRC- 1015
Query: 122 TVANQFSCKCLTGFTGQKCETDVNEC---------DIPGHCQHGGTCLNLPGSYQCQCLQ 172
V C C G++G+ C+ C + CQ GG C++ S+ C C +
Sbjct: 1016 -VQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGVRLEQLCQAGGQCVDEDSSHYCVCPE 1074
Query: 173 GFTGQYCDSLYVPCAPSPCVNGGTCR-QTGDFTFECNCLP 211
G TG +C+ PC PC +GGTCR G + C CLP
Sbjct: 1075 GRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYM--CECLP 1112
Score = 141 bits (355), Expect = 6e-34
Identities = 78/244 (31%), Positives = 106/244 (43%), Gaps = 46/244 (18%)
Query: 7 NGTGY-CKCPEGFLGEYCQHRDPCEKNRCQNGGTC------------------------- 40
+G G+ C CP G G C+ PC N C++GG C
Sbjct: 752 DGMGFHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDV 811
Query: 41 -------------VAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSR 87
+ + G +C C G+TG C + PCLNGG+C
Sbjct: 812 DECAGPAPCGPHGICTNLAGSFSCTCHGGYTGPSCDQDIND--CDPNPCLNGGSCQD-GV 868
Query: 88 DTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNE 146
++ C+C GF G C + D CLS+PC G TCT F+C C G+ G CE D+ +
Sbjct: 869 GSFSCSCLPGFAGPRCARDVDECLSNPCGPG-TCTDHVASFTCTCPPGYGGFHCEQDLPD 927
Query: 147 CDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFE 206
C P C +GGTC++ S+ C C G+TG +C PC PC++GG C F
Sbjct: 928 CS-PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVC-SAAHPGFR 985
Query: 207 CNCL 210
C CL
Sbjct: 986 CTCL 989
Score = 131 bits (329), Expect = 6e-31
Identities = 74/206 (35%), Positives = 97/206 (47%), Gaps = 19/206 (9%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSH-- 68
C CP GF G CQ D C C+NG CV Q CRCA GF G C +
Sbjct: 493 CTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQP--DGYECRCAEGFEGTLCDRNVDDCS 550
Query: 69 --PCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-WTDACLSHPCANGSTCTTVAN 125
PC R C++G ++ C C G+TG C+ D C S PC +G C + +
Sbjct: 551 PDPCHHGR-CVDGIA-------SFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVD 602
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
++ C+C +G TG CE ++++C C G C + Y C C GFTG C+
Sbjct: 603 KYLCRCPSGTTGVNCEVNIDDC-ASNPCTF-GVCRDGINRYDCVCQPGFTGPLCNVEINE 660
Query: 186 CAPSPCVNGGTCRQTGDFTFECNCLP 211
CA SPC GG+C G+ F C C P
Sbjct: 661 CASSPCGEGGSC-VDGENGFRCLCPP 685
Score = 122 bits (307), Expect = 2e-28
Identities = 76/210 (36%), Positives = 96/210 (45%), Gaps = 23/210 (10%)
Query: 10 GY-CKCPEGFLGEYCQHR------DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC 62
GY C+C EGF G C DPC RC +G + +C CA G+TG C
Sbjct: 528 GYECRCAEGFEGTLCDRNVDDCSPDPCHHGRCVDG--------IASFSCACAPGYTGTRC 579
Query: 63 QYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCT 121
+ S C S+PC +GG C L D Y C C G TG C+ D C S+PC G C
Sbjct: 580 E-SQVDECR-SQPCRHGGKCLDLV-DKYLCRCPSGTTGVNCEVNIDDCASNPCTFG-VCR 635
Query: 122 TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDS 181
N++ C C GFTG C ++NEC C GG+C++ ++C C G C
Sbjct: 636 DGINRYDCVCQPGFTGPLCNVEINEC-ASSPCGEGGSCVDGENGFRCLCPPGSLPPLCLP 694
Query: 182 LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
PCA PC +G G F C C P
Sbjct: 695 PSHPCAHEPCSHGICYDAPGG--FRCVCEP 722
Score = 83.2 bits (204), Expect = 2e-16
Identities = 62/203 (30%), Positives = 84/203 (41%), Gaps = 33/203 (16%)
Query: 6 HNGT------GY-CKCPEGFLGEYCQHRDPCEKNRCQNGGTCVA------QAMLGKATCR 52
HNGT G+ C CP G+ G C+ + N C++G A Q G C
Sbjct: 1178 HNGTCVDLVGGFRCTCPPGYTGLRCE----ADINECRSGACHAAHTRDCLQDPGGGFRCL 1233
Query: 53 CASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRD----TYECTCQVGFTGKECQWTD- 107
C +GF+G CQ S PC S+PC +GG C T+ C C F G C+
Sbjct: 1234 CHAGFSGPRCQTVLS-PC-ESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVAR 1291
Query: 108 ACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCET-------DVNECDIPGHCQHGGTCL 160
+C C G C C C G +G C + N C HGG+C
Sbjct: 1292 SCRELQCPVGVPCQQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCR 1351
Query: 161 NLPGS--YQCQCLQGFTGQYCDS 181
P + ++C C QG+TG C++
Sbjct: 1352 PAPLAPFFRCACAQGWTGPRCEA 1374
Score = 76.3 bits (186), Expect = 2e-14
Identities = 67/235 (28%), Positives = 82/235 (34%), Gaps = 53/235 (22%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQH-RDPCEKNRCQNGGTCVAQAMLGKA---TCRCASGF 57
C+ G C C GF G CQ PCE CQ+GG C G TC CA F
Sbjct: 1222 CLQDPGGGFRCLCHAGFSGPRCQTVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPF 1281
Query: 58 TGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ---------WTDA 108
G C+ + C C G C R C C G +G C+ +
Sbjct: 1282 WGPRCE-RVARSC-RELQCPVGVPCQQTPRGP-RCACPPGLSGPSCRSFPGSPPGASNAS 1338
Query: 109 CLSHPCANGSTC--TTVANQFSCKCLTGFTGQKCETDV---------------------- 144
C + PC +G +C +A F C C G+TG +CE
Sbjct: 1339 CAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRCEAPAAAPEVSEEPRCPRAACQAKRGD 1398
Query: 145 ----NECDIPGHCQHGGTCLNLPGS--YQC---QCLQGFTGQYCDSLYVPCAPSP 190
EC+ PG GG C G QC QC + F CD P SP
Sbjct: 1399 QRCDRECNSPGCGWDGGDCSLSVGDPWRQCEALQCWRLFNNSRCD----PACSSP 1449
Score = 42.4 bits (98), Expect = 4e-04
Identities = 42/189 (22%), Positives = 60/189 (31%), Gaps = 36/189 (19%)
Query: 12 CKCPEGFLGEYCQH---------RDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC 62
C CP G G C+ C C +GG+C + C CA G+TG C
Sbjct: 1313 CACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPFFRCACAQGWTGPRC 1372
Query: 63 QYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCT- 121
+ + P P C R C + G C W +G C+
Sbjct: 1373 EAPAAAPEVSEEPRCPRAAC-QAKRGDQRCDRECNSPG--CGW----------DGGDCSL 1419
Query: 122 TVANQF----SCKCLTGFTGQKCETDVNECDIPG------HCQHGGTCLNLPGSYQCQCL 171
+V + + + +C F +C+ C P C GG Y+ C
Sbjct: 1420 SVGDPWRQCEALQCWRLFNNSRCDP---ACSSPACLYDNFDCHAGGRERTCNPVYEKYCA 1476
Query: 172 QGFTGQYCD 180
F CD
Sbjct: 1477 DHFADGRCD 1485
Score = 28.5 bits (62), Expect = 5.3
Identities = 15/37 (40%), Positives = 16/37 (43%), Gaps = 1/37 (2%)
Query: 185 PCAP-SPCVNGGTCRQTGDFTFECNCLPETVRRGTEL 220
PC SPC NGG C Q C C P V +L
Sbjct: 42 PCLDGSPCANGGRCTQLPSREAACLCPPGWVGERCQL 78
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 181 bits (458), Expect = 6e-46
Identities = 97/227 (42%), Positives = 117/227 (51%), Gaps = 18/227 (7%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNR-CQNGGTCVA--QAMLGKAT-------- 50
C++ G G C+C GFLGE CQ DPC+ + CQNGG+C A A LG +
Sbjct: 41 CLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSSPSPLTPS 100
Query: 51 --CRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDA 108
C C GFTGE CQ PC S C G CH+ + +C+C G+TG++CQ D
Sbjct: 101 FLCTCLPGFTGERCQAKLEDPCPPSF-CSKRGRCHIQASGRPQCSCMPGWTGEQCQLRDF 159
Query: 109 CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNEC-DIPGHCQHGGTCLNLPGSYQ 167
C ++PC NG C Q C C GF G CE DVNEC PG C G +C N GS+Q
Sbjct: 160 CSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTSCHNTLGSFQ 219
Query: 168 CQCLQGFTGQYCDSLYVPCAPSPCVNGGTCR--QTGDFTFE-CNCLP 211
C C G G C+ PC P C NGGTC+ D TF C C P
Sbjct: 220 CLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPP 266
Score = 149 bits (375), Expect = 3e-36
Identities = 81/206 (39%), Positives = 107/206 (51%), Gaps = 15/206 (7%)
Query: 8 GTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
G+ C CP G+ G C+ + C C G TC+ +L C C G G+ C+ T
Sbjct: 457 GSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLD--LLATFHCLCPPGLEGQLCEVET 514
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 125
+ S PCLN CH L ++C C GF+G C+ D C S PCANG C
Sbjct: 515 NE--CASAPCLNHADCHDLLNG-FQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPG 571
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
F CKCL GF G +C+T+V+EC + C G +CL+LPG++ C C GFTGQ C+ VP
Sbjct: 572 AFHCKCLPGFEGPRCQTEVDEC-LSDPCPVGASCLDLPGAFFCLCPSGFTGQLCE---VP 627
Query: 186 -CAPSPCVNGGTCRQTGDFTFECNCL 210
CAP+ C C+ D + NCL
Sbjct: 628 LCAPNLCQPKQICKDQKD---KANCL 650
Score = 148 bits (374), Expect = 3e-36
Identities = 85/214 (39%), Positives = 103/214 (48%), Gaps = 20/214 (9%)
Query: 11 YCKCPEGFLGEYCQ-HRDPCEK----------NRCQNGGTCVAQAMLGKATCRCASGFTG 59
+C C +G+ G C C+K + C NGG CV C C GF G
Sbjct: 867 HCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGP--SYFCHCPPGFQG 924
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGS 118
CQ + PC SRPC NG TC M Y C C G+ G+ C + DAC S PC N
Sbjct: 925 SLCQDHVN-PC-ESRPCQNGATC-MAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHG 981
Query: 119 TCTTVANQFSCKCLTGFTGQKCETDVNEC-DIPGHCQHGGTCLNLPGSYQCQCLQGFTGQ 177
TCT F C C GF G +CE DV+EC D P H C +L ++ CQCL G TGQ
Sbjct: 982 TCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQ 1041
Query: 178 YCDSLYVPCAPSPCVNGGTCRQT--GDFTFECNC 209
+C+ PC PC +GGTC T F C+C
Sbjct: 1042 WCEVEIDPCHSQPCFHGGTCEATAGSPLGFICHC 1075
Score = 145 bits (365), Expect = 4e-35
Identities = 84/256 (32%), Positives = 113/256 (44%), Gaps = 51/256 (19%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGED 61
C +G C C G+ GE CQ RD C N C NGG C+A + C C GF G
Sbjct: 133 CHIQASGRPQCSCMPGWTGEQCQLRDFCSANPCVNGGVCLAT--YPQIQCHCPPGFEGHA 190
Query: 62 CQYSTSHPCFVS---------------------------------------RPCLNGGTC 82
C+ + CF R C NGGTC
Sbjct: 191 CERDVNE-CFQDPGPCPKGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTC 249
Query: 83 HML-SRDT--YECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQ 138
++ +D+ + C C GF G +C+ D C+SH C NG TC + ++C C +TG
Sbjct: 250 QLMPEKDSTFHLCLCPPGFIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGW 309
Query: 139 KCETDVNECDI--PGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGT 196
C DV+EC+ P HC++GGTC N GS+ C C+ G+ G C+ C + C G T
Sbjct: 310 DCSEDVDECETQGPPHCRNGGTCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGST 369
Query: 197 C-RQTGDFTFECNCLP 211
C + G +F C C P
Sbjct: 370 CIDRVG--SFSCLCPP 383
Score = 145 bits (365), Expect = 4e-35
Identities = 74/209 (35%), Positives = 97/209 (46%), Gaps = 9/209 (4%)
Query: 8 GTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
G+ C CP G G C D C C C + G C C G++G C
Sbjct: 375 GSFSCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLD 434
Query: 68 HPCFVSR----PCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTT 122
C +++ PC +GG+C + + ++ C C G+TG C+ + CLS PC GSTC
Sbjct: 435 E-CLMAQQGPSPCEHGGSC-LNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLD 492
Query: 123 VANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSL 182
+ F C C G GQ CE + NEC C + C +L +QC CL GF+G C+
Sbjct: 493 LLATFHCLCPPGLEGQLCEVETNEC-ASAPCLNHADCHDLLNGFQCICLPGFSGTRCEED 551
Query: 183 YVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C SPC NGG C Q F C CLP
Sbjct: 552 IDECRSSPCANGGQC-QDQPGAFHCKCLP 579
Score = 145 bits (365), Expect = 4e-35
Identities = 83/209 (39%), Positives = 103/209 (49%), Gaps = 15/209 (7%)
Query: 11 YCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
+C CP GF G CQ H +PCE CQNG TC+AQ C+CA G+ G++C S
Sbjct: 915 FCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQP--SGYLCQCAPGYDGQNC--SKELD 970
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGST--CTTVANQ 126
S+PC N GTC + C C GF G C+ D CL PC T C ++AN
Sbjct: 971 ACQSQPCHNHGTCTP-KPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANA 1029
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGS---YQCQCLQGFTGQYCDSLY 183
F C+CL G TGQ CE +++ C C HGGTC GS + C C +GF G C
Sbjct: 1030 FYCQCLPGHTGQWCEVEIDPCHSQP-CFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRA 1088
Query: 184 VPCAPSPCVNGGTCRQT--GDFTFECNCL 210
C C +GG C + F C CL
Sbjct: 1089 PSCGFHHCHHGGLCLPSPKPGFPPRCACL 1117
Score = 143 bits (360), Expect = 1e-34
Identities = 87/247 (35%), Positives = 111/247 (44%), Gaps = 52/247 (21%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C CP GF+G C+ + D C ++CQNGGTC Q L TC C +TG DC C
Sbjct: 262 CLCPPGFIGPDCEVNPDNCVSHQCQNGGTC--QDGLDTYTCLCPETWTGWDCSEDVDE-C 318
Query: 71 FVSRP--CLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQF 127
P C NGGTC S ++ C C G+ G C+ D C++ CA GSTC F
Sbjct: 319 ETQGPPHCRNGGTCQN-SAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSF 377
Query: 128 SCKC------------------------------LTG---------FTGQKCETDVNECD 148
SC C LTG ++G C D++EC
Sbjct: 378 SCLCPPGRTGLLCHLEDMCLSQPCHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECL 437
Query: 149 I----PGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFT 204
+ P C+HGG+CLN PGS+ C C G+TG C++ + C PC G TC T
Sbjct: 438 MAQQGPSPCEHGGSCLNTPGSFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDL-LAT 496
Query: 205 FECNCLP 211
F C C P
Sbjct: 497 FHCLCPP 503
Score = 141 bits (356), Expect = 4e-34
Identities = 81/212 (38%), Positives = 100/212 (47%), Gaps = 11/212 (5%)
Query: 4 TYHNG---TGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTG 59
T H+G C C G+ G C+ C C +GGTC Q C C +G+TG
Sbjct: 666 TCHHGHCQRSSCVCDVGWTGPECEAELGGCISAPCAHGGTCYPQP--SGYNCTCPTGYTG 723
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGS 118
C S S PCLNGG+C+ S Y CTC TG +CQ TD C+S PC NG
Sbjct: 724 PTC--SEEMTACHSGPCLNGGSCNP-SPGGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGG 780
Query: 119 TCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQY 178
TC FSC C GF G +CE + C++ TC + P +C C G+TG
Sbjct: 781 TCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGS 840
Query: 179 CDSLYVPCAPSPCVNGGTCRQTGDFTFECNCL 210
C +L CA PC C QTG +F C CL
Sbjct: 841 CQTLMDLCAQKPCPRNSHCLQTGP-SFHCLCL 871
Score = 139 bits (349), Expect = 3e-33
Identities = 79/215 (36%), Positives = 91/215 (42%), Gaps = 16/215 (7%)
Query: 8 GTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
G YC CP G CQ D C C NGGTCV + G +C CA GF G C+
Sbjct: 749 GGYYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRP--GTFSCLCAMGFQGPRCEGKL 806
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 125
C S PC N TC S C C G+TG CQ D C PC S C
Sbjct: 807 RPSCADS-PCRNRATCQD-SPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGP 864
Query: 126 QFSCKCLTGFTGQKCETDVNEC---------DIPGHCQHGGTCLNLPGSYQCQCLQGFTG 176
F C CL G+TG C ++ C D+ C +GG C++ SY C C GF G
Sbjct: 865 SFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCVDSGPSYFCHCPPGFQG 924
Query: 177 QYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C PC PC NG TC + C C P
Sbjct: 925 SLCQDHVNPCESRPCQNGATC-MAQPSGYLCQCAP 958
Score = 105 bits (263), Expect = 3e-23
Identities = 56/153 (36%), Positives = 75/153 (49%), Gaps = 18/153 (11%)
Query: 75 PCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACL-SHPCANGSTC------------- 120
PC NGGTC LS C C GF G+ CQ+ D C + C NG +C
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLPSS 93
Query: 121 -TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC-LNLPGSYQCQCLQGFTGQY 178
+ + F C CL GFTG++C+ + + P C G C + G QC C+ G+TG+
Sbjct: 94 PSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMPGWTGEQ 153
Query: 179 CDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C L C+ +PCVNGG C T +C+C P
Sbjct: 154 C-QLRDFCSANPCVNGGVCLATYP-QIQCHCPP 184
Score = 90.9 bits (224), Expect = 9e-19
Identities = 56/185 (30%), Positives = 76/185 (41%), Gaps = 15/185 (8%)
Query: 8 GTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
G +C CP GF+G C+ D C C GT ++ C+C G TG+ C+
Sbjct: 988 GGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEI 1047
Query: 67 SHPCFVSRPCLNGGTCHMLSRDT--YECTCQVGFTGKECQW-TDACLSHPCANGSTCTTV 123
PC S+PC +GGTC + + C C GF G C +C H C +G C
Sbjct: 1048 D-PCH-SQPCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPS 1105
Query: 124 ANQF---SCKCLTGFTGQKCETD--VNECDIPGHCQHGGTCLNLPG----SYQCQCLQGF 174
C CL+G+ G C T C P C + G+C G ++C C
Sbjct: 1106 PKPGFPPRCACLSGYGGPDCLTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSS 1165
Query: 175 TGQYC 179
G C
Sbjct: 1166 PGPRC 1170
Score = 66.6 bits (161), Expect = 2e-11
Identities = 64/224 (28%), Positives = 87/224 (38%), Gaps = 39/224 (17%)
Query: 12 CKCPEGFLGEYCQHRDP-CEKNRCQNGGTCVAQAMLG-KATCRCASGFTGEDCQYSTS-H 68
C CP+GF G C HR P C + C +GG C+ G C C SG+ G DC +
Sbjct: 1073 CHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAPK 1132
Query: 69 PCFVSRPCLNGGTCHM---LSRDTYECTCQVGFTGKECQ--------------WTDACLS 111
C PCL G+C L + C+C G CQ DA S
Sbjct: 1133 GCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCS 1192
Query: 112 HPCAN--GSTCTT-VANQFS-----CKCLTGFTGQKC--ETDVNECDIPGH-CQHGGTCL 160
P N G C+ V + + +C F +C + D EC G+ C+ C
Sbjct: 1193 GPGGNWDGGDCSLGVPDPWKGCPSHSRCWLLFRDGQCHPQCDSEECLFDGYDCETPPAC- 1251
Query: 161 NLPGSYQCQCLQGFTGQYCDSLYVPCAPSPC-VNGGTCR-QTGD 202
+Y C F +C+ C + C +GG CR + GD
Sbjct: 1252 --TPAYDQYCHDHFHNGHCEK---GCNTAECGWDGGDCRPEDGD 1290
Score = 44.3 bits (103), Expect = 9e-05
Identities = 27/82 (32%), Positives = 32/82 (39%), Gaps = 26/82 (31%)
Query: 150 PGHCQHGGTCLNLP-GSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDF----- 203
P C +GGTCL+L G CQC GF G+ C P PC N C+ G
Sbjct: 32 PEPCANGGTCLSLSLGQGTCQCAPGFLGETCQ------FPDPCQNAQLCQNGGSCQALLP 85
Query: 204 --------------TFECNCLP 211
+F C CLP
Sbjct: 86 APLGLPSSPSPLTPSFLCTCLP 107
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 157 bits (398), Expect = 6e-39
Identities = 88/245 (35%), Positives = 114/245 (46%), Gaps = 44/245 (17%)
Query: 2 CVTYHNGT---GYCKCPEGFLGEYCQHRDP----------------CEKN---------- 32
C H G G C+C G+ G +C P CE N
Sbjct: 249 CNLLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDL 308
Query: 33 -------RCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHML 85
C NGGTC+ A + C C G++G +C+ H C S PC NGG+CH +
Sbjct: 309 NYCGSHHPCTNGGTCI-NAEPDQYRCTCPDGYSGRNCE-KAEHAC-TSNPCANGGSCHEV 365
Query: 86 SRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDV 144
+EC C G++G C D C S+PCA G TC + F C C + G C+ DV
Sbjct: 366 PSG-FECHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDV 424
Query: 145 NECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFT 204
N+C G CQHGGTC +L YQC C +GF G++C+ CA SPC +GG C D
Sbjct: 425 NDCR--GQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLAD-G 481
Query: 205 FECNC 209
F C+C
Sbjct: 482 FHCHC 486
Score = 143 bits (361), Expect = 1e-34
Identities = 77/212 (36%), Positives = 100/212 (47%), Gaps = 8/212 (3%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
CV+ G C C GF G YC D C C+NGGTC+ + + C C SG+ GE
Sbjct: 574 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDE--VDAFRCFCPSGWEGE 631
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANGST 119
C + + C PC + G C+ L D Y C C G+ GK C + C ++ C+NG T
Sbjct: 632 LCD-TNPNDCLPD-PCHSRGRCYDLVNDFY-CACDDGWKGKTCHSREFQCDAYTCSNGGT 688
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
C + F C C G+ G C N +P C +GGTC+ S+ C C G+ G+ C
Sbjct: 689 CYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTC 748
Query: 180 DSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C P PC NGG C G F C C P
Sbjct: 749 THNTNDCNPLPCYNGGIC-VDGVNWFRCECAP 779
Score = 126 bits (316), Expect = 2e-29
Identities = 77/228 (33%), Positives = 107/228 (46%), Gaps = 32/228 (14%)
Query: 8 GTGYCKCPEGFLGEYCQ-HRDPCEKNRCQ-----------------------NGGTCVAQ 43
G YC CP+ F G+ C R+PC C+ G CV+Q
Sbjct: 518 GDYYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQ 577
Query: 44 AMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC 103
G +C C SGFTG C + C + +PC NGGTC + D + C C G+ G+ C
Sbjct: 578 PG-GNFSCICDSGFTGTYC-HENIDDC-LGQPCRNGGTC-IDEVDAFRCFCPSGWEGELC 633
Query: 104 QWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNL 162
+ CL PC + C + N F C C G+ G+ C + +CD C +GGTC +
Sbjct: 634 DTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD-AYTCSNGGTCYDS 692
Query: 163 PGSYQCQCLQGFTGQYCD-SLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
+++C C G+ G C + C P+PCVNGGTC +G +F C C
Sbjct: 693 GDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG-ASFSCIC 739
Score = 122 bits (307), Expect = 2e-28
Identities = 60/174 (34%), Positives = 87/174 (50%), Gaps = 7/174 (4%)
Query: 11 YCKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
YC C +G+ G+ C R+ C+ C NGGTC + C C G+ G C + +
Sbjct: 659 YCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR--CACPPGWKGSTCAVAKNSS 716
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFS 128
C + PC+NGGTC + S ++ C C+ G+ G+ C T+ C PC NG C N F
Sbjct: 717 C-LPNPCVNGGTC-VGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFR 774
Query: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSL 182
C+C GF G C +++EC C +G TC++ Y+C C G G C +
Sbjct: 775 CECAPGFAGPDCRINIDECQ-SSPCAYGATCVDEINGYRCSCPPGRAGPRCQEV 827
Score = 121 bits (304), Expect = 5e-28
Identities = 73/222 (32%), Positives = 96/222 (43%), Gaps = 30/222 (13%)
Query: 12 CKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCF 71
C CPE ++G CQ + +CQ+GGTC + ++ C C GF G C+
Sbjct: 409 CICPEQWVGATCQLDVNDCRGQCQHGGTC--KDLVNGYQCVCPRGFGGRHCELERDE--C 464
Query: 72 VSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFSCK 130
S PC +GG C L+ D + C C GF+G C+ D C PC NG+ C + + C
Sbjct: 465 ASSPCHSGGLCEDLA-DGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCA 523
Query: 131 CLTGFTGQKCETDVNECD-----------------IPGHCQHG-----GTCLNLPG-SYQ 167
C F G+ C C +PG G G C++ PG ++
Sbjct: 524 CPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPGGNFS 583
Query: 168 CQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
C C GFTG YC C PC NGGTC D F C C
Sbjct: 584 CICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVD-AFRCFC 624
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 156 bits (395), Expect = 1e-38
Identities = 91/253 (35%), Positives = 117/253 (46%), Gaps = 57/253 (22%)
Query: 6 HNG-------TGY-CKCPEGFLGEYCQHR--DPCEKNRCQNGGTCVAQAMLGKATCRCAS 55
HNG GY C+CPEGF+G C+ R D CE C+NGG C+ C+C
Sbjct: 439 HNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCE---CRNGGRCLGA---NTTLCQCPL 492
Query: 56 GFTGEDCQYS-TSHPCFV------------------------------------SRPCLN 78
GF G C++ T+ PC + S PC N
Sbjct: 493 GFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCHTDHNASHSLPSPCDSDPCFN 552
Query: 79 GGTCHMLSRDTYECTCQVGFTGKECQWT--DACLSHPCANGSTCTTVANQFSCKCLTGFT 136
GG+C D+Y C C GF GK C+ C S PC NG TC ++ C C FT
Sbjct: 553 GGSCDAHD-DSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFT 611
Query: 137 GQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGT 196
G+ CE + G C +GGTC + G Y+C C GF+G++C+ PC SPCVNGGT
Sbjct: 612 GRHCEIGKPDSCASGPCHNGGTCFHYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGT 671
Query: 197 CRQTGDFTFECNC 209
C + D F C+C
Sbjct: 672 C-EDRDTDFFCHC 683
Score = 137 bits (345), Expect = 8e-33
Identities = 80/263 (30%), Positives = 111/263 (42%), Gaps = 63/263 (23%)
Query: 5 YHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ 63
++ G C CP GF G +C+ PC ++ C NGGTC + C C +G+ G CQ
Sbjct: 636 HYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDT--DFFCHCQAGYMGRRCQ 693
Query: 64 ----------------------------------YSTSHPCFV----------------- 72
YS S P +
Sbjct: 694 AEVDCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLE 753
Query: 73 -----SRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQ 126
S+PCL+GG+C Y C C G+ G C+ D C +HPC NG +C +
Sbjct: 754 IDECRSQPCLHGGSCQDRVAG-YLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGA 812
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPC 186
+ C+C GF G CET+V+ CD CQHGG C + G+Y C C + F G +C+++ PC
Sbjct: 813 YVCRCPAGFVGVHCETEVDACD-SSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPC 871
Query: 187 APSPCVNGGTCRQTGDFTFECNC 209
SPC G C + + C C
Sbjct: 872 FSSPCGGRGYCLASNG-SHSCTC 893
Score = 132 bits (331), Expect = 3e-31
Identities = 66/151 (43%), Positives = 82/151 (54%), Gaps = 7/151 (4%)
Query: 62 CQYSTSHPCFVSRPCLNGGTCH---MLSRDTYECTCQVGFTGKECQW-TDACLSHPCANG 117
C ++TS C RPCLNGG C + +Y C+C GFTG+ C + C S PC NG
Sbjct: 265 CGHTTS-VCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNG 323
Query: 118 STCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQ 177
TCT N F C+C GF G CET + CD CQHGG C GS C C G+TG
Sbjct: 324 GTCTHGINSFRCQCPAGFGGPTCETAQSPCDTK-ECQHGGQCQVENGSAVCVCQAGYTGA 382
Query: 178 YCDSLYVPCAPSPCVNGGTCRQ-TGDFTFEC 207
C+ C+P PC+NGG+C G++T C
Sbjct: 383 ACEMDVDDCSPDPCLNGGSCVDLVGNYTCLC 413
Score = 131 bits (330), Expect = 4e-31
Identities = 69/184 (37%), Positives = 94/184 (51%), Gaps = 14/184 (7%)
Query: 34 CQNGGTCVAQAMLGKA--TCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC-HMLSRDTY 90
C NGG C+ + G TC C SGFTG C + S+PC NGGTC H + +++
Sbjct: 278 CLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNE--CASQPCQNGGTCTHGI--NSF 333
Query: 91 ECTCQVGFTGKECQWTDA-CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDI 149
C C GF G C+ + C + C +G C C C G+TG CE DV++C
Sbjct: 334 RCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCS- 392
Query: 150 PGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP----CAPSPCVNGGTCRQTGDFTF 205
P C +GG+C++L G+Y C C + F G C++ P C +PC NGGTC D +
Sbjct: 393 PDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTC-VDADQGY 451
Query: 206 ECNC 209
C C
Sbjct: 452 VCEC 455
Score = 129 bits (323), Expect = 3e-30
Identities = 78/214 (36%), Positives = 103/214 (48%), Gaps = 17/214 (7%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRD--PCEKNRCQNGGTCVAQAMLGKATCRCASGFTG 59
CVT N + C C GF G C H D C CQNGGTC + C+C +GF G
Sbjct: 288 CVT-GNPSYTCSCLSGFTGRRC-HLDVNECASQPCQNGGTCTHG--INSFRCQCPAGFGG 343
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGS 118
C+ + S PC ++ C +GG C + + C CQ G+TG C+ D C PC NG
Sbjct: 344 PTCETAQS-PC-DTKECQHGGQC-QVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGG 400
Query: 119 TCTTVANQFSCKCLTGFTGQKCET---DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFT 175
+C + ++C C F G +CET V + + C +GGTC++ Y C+C +GF
Sbjct: 401 SCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFM 460
Query: 176 GQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
G C VP C NGG C G T C C
Sbjct: 461 GLDCRE-RVP-DDCECRNGGRC--LGANTTLCQC 490
Score = 128 bits (322), Expect = 4e-30
Identities = 78/208 (37%), Positives = 104/208 (50%), Gaps = 21/208 (10%)
Query: 12 CKCPEGFLGEYCQH-RDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C+CP GF G C+ + PC+ CQ+GG C Q G A C C +G+TG C+ C
Sbjct: 335 CQCPAGFGGPTCETAQSPCDTKECQHGGQC--QVENGSAVCVCQAGYTGAACEMDVDD-C 391
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-----TDACLSHPCANGSTCTTVAN 125
PCLNGG+C L + Y C C F G C+ DACLS PC NG TC
Sbjct: 392 SPD-PCLNGGSCVDLVGN-YTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQ 449
Query: 126 QFSCKCLTGFTGQKCETDV-NECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC--DSL 182
+ C+C GF G C V ++C+ C++GG CL + CQC GF G C +
Sbjct: 450 GYVCECPEGFMGLDCRERVPDDCE----CRNGGRCLG-ANTTLCQCPLGFFGLLCEFEIT 504
Query: 183 YVPC-APSPCVNGGTCRQTGDFTFECNC 209
+PC + C +GG C + G ++ C C
Sbjct: 505 AMPCNMNTQCPDGGYCMEHGG-SYLCVC 531
Score = 124 bits (311), Expect = 7e-29
Identities = 78/266 (29%), Positives = 107/266 (40%), Gaps = 69/266 (25%)
Query: 6 HNGTGYCKCPEGFLGEYCQHRDP--CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ 63
H+ + C+CP GF G++C+ P C C+NGGTC G+ C C FTG C+
Sbjct: 559 HDDSYTCECPRGFHGKHCEKARPHLCSSGPCRNGGTCKEAG--GEYHCSCPYRFTGRHCE 616
Query: 64 YSTSHPCFVSRPCLNGGTC-HMLSRDTYECTCQVGFTGKECQWTDA-CLSHPCANGSTCT 121
C S PC NGGTC H + + Y+C C GF+G+ C+ + C PC NG TC
Sbjct: 617 IGKPDSC-ASGPCHNGGTCFHYIGK--YKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCE 673
Query: 122 TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQH-----GGTCLNLPGSYQC-------- 168
F C C G+ G++C+ +V +C P +H GT L Y C
Sbjct: 674 DRDTDFFCHCQAGYMGRRCQAEV-DCGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSA 732
Query: 169 -----------------QCLQ----------------------------GFTGQYCDSLY 183
QCL+ G+ G +C+
Sbjct: 733 PSRIRVCQPHGVWSEPPQCLEIDECRSQPCLHGGSCQDRVAGYLCLCSTGYEGAHCELER 792
Query: 184 VPCAPSPCVNGGTCRQTGDFTFECNC 209
C PC NGG+CR + C C
Sbjct: 793 DECRAHPCRNGGSCRNLPG-AYVCRC 817
Score = 93.6 bits (231), Expect = 1e-19
Identities = 49/138 (35%), Positives = 66/138 (47%), Gaps = 8/138 (5%)
Query: 10 GY-CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
GY C C G+ G +C+ RD C + C+NGG+C + + G CRC +GF G C+ T
Sbjct: 774 GYLCLCSTGYEGAHCELERDECRAHPCRNGGSC--RNLPGAYVCRCPAGFVGVHCE--TE 829
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQ 126
S PC +GG C Y C C F G C+ +D C S PC C
Sbjct: 830 VDACDSSPCQHGGRCES-GGGAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASNGS 888
Query: 127 FSCKCLTGFTGQKCETDV 144
SC C G+TG+ C ++
Sbjct: 889 HSCTCKVGYTGEDCAKEL 906
Score = 52.0 bits (123), Expect = 4e-07
Identities = 24/56 (42%), Positives = 30/56 (53%), Gaps = 3/56 (5%)
Query: 8 GTGYCKCPEGFLGEYCQH-RDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC 62
G C CPE F G +C+ DPC + C G C+A G +C C G+TGEDC
Sbjct: 849 GAYLCVCPESFFGYHCETVSDPCFSSPCGGRGYCLASN--GSHSCTCKVGYTGEDC 902
Score = 47.4 bits (111), Expect = 1e-05
Identities = 29/87 (33%), Positives = 39/87 (44%), Gaps = 12/87 (13%)
Query: 29 CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYS---TSHPC------FVSRPCLNG 79
C +N CQNGGTCV A +C C GF G C+ + S PC + P G
Sbjct: 1311 CSENPCQNGGTCVPGA--DAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWEG 1368
Query: 80 GTCHMLSRDTYECTCQVGFTGKECQWT 106
G CH + + Y + F + C+ T
Sbjct: 1369 GVCHHVYKRVYRVHQDICFK-ESCEST 1394
Score = 42.4 bits (98), Expect = 4e-04
Identities = 16/33 (48%), Positives = 20/33 (60%)
Query: 109 CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCE 141
C +PC NG TC A+ SC C GF G++CE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 40.8 bits (94), Expect = 0.001
Identities = 17/40 (42%), Positives = 22/40 (55%), Gaps = 1/40 (2%)
Query: 75 PCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPC 114
PC NGGTC + D + C C GF G+ C+ +S PC
Sbjct: 1315 PCQNGGTC-VPGADAHSCDCGPGFKGRRCELACIKVSRPC 1353
Score = 35.8 bits (81), Expect = 0.033
Identities = 20/66 (30%), Positives = 30/66 (45%), Gaps = 16/66 (24%)
Query: 148 DIPGHC-----QHGGTCLNLPGSYQCQCLQGFTGQYCDSLYV----PCA-------PSPC 191
++PG+C Q+GGTC+ ++ C C GF G+ C+ + PC P
Sbjct: 1306 NVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPV 1365
Query: 192 VNGGTC 197
GG C
Sbjct: 1366 WEGGVC 1371
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 152 bits (385), Expect = 2e-37
Identities = 81/204 (39%), Positives = 110/204 (53%), Gaps = 10/204 (4%)
Query: 12 CKCPEGFLGEYC-QHRDPCEKNR-CQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
C C EG+ G +C Q + C ++ C+NG TC G TC C G+TG C+
Sbjct: 274 CNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQ-GSYTCSCRPGYTGATCELGIDE- 331
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANGSTCTTVANQ-F 127
C S PC NGG+C L ++Y CTC GF GK C+ + C PC NG C+ + +
Sbjct: 332 CDPS-PCKNGGSCTDLE-NSYSCTCPPGFYGKICELSAMTCADGPCFNGGRCSDSPDGGY 389
Query: 128 SCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCA 187
SC+C G++G CE ++ C C +G C++L +Y C+C GF+G++CD CA
Sbjct: 390 SCRCPVGYSGFNCEKKIDYCS-SSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCA 448
Query: 188 PSPCVNGGTCRQTGDFTFECNCLP 211
SPC NGGTCR G F C C P
Sbjct: 449 SSPCANGGTCRD-GVNDFSCTCPP 471
Score = 149 bits (375), Expect = 3e-36
Identities = 71/210 (33%), Positives = 106/210 (50%), Gaps = 8/210 (3%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
C G+ C C G+ G C+ D C+ + C+NGG+C + +C C GF G+
Sbjct: 304 CTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTD--LENSYSCTCPPGFYGK 361
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGST 119
C+ S PC NGG C Y C C VG++G C+ D C S PC+NG+
Sbjct: 362 ICELSAM--TCADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAK 419
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
C + + + C+C GF+G+ C+ +V++C C +GGTC + + C C G+TG+ C
Sbjct: 420 CVDLGDAYLCRCQAGFSGRHCDDNVDDC-ASSPCANGGTCRDGVNDFSCTCPPGYTGRNC 478
Query: 180 DSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
+ C +PC NG TC + G + C C
Sbjct: 479 SAPVSRCEHAPCHNGATCHERG-HRYVCEC 507
Score = 137 bits (345), Expect = 8e-33
Identities = 71/183 (38%), Positives = 91/183 (49%), Gaps = 7/183 (3%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C CP GF G+ C+ C C NGG C + + G +CRC G++G +C+ +
Sbjct: 352 CTCPPGFYGKICELSAMTCADGPCFNGGRC-SDSPDGGYSCRCPVGYSGFNCEKKIDYCS 410
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSC 129
S PC NG C L D Y C CQ GF+G+ C D C S PCANG TC N FSC
Sbjct: 411 --SSPCSNGAKCVDLG-DAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSC 467
Query: 130 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPS 189
C G+TG+ C V+ C+ C +G TC Y C+C +G+ G C L P
Sbjct: 468 TCPPGYTGRNCSAPVSRCE-HAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPG 526
Query: 190 PCV 192
P V
Sbjct: 527 PAV 529
Score = 127 bits (319), Expect = 8e-30
Identities = 71/199 (35%), Positives = 97/199 (48%), Gaps = 20/199 (10%)
Query: 14 CPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVS 73
C G+ G YC C + G C C+C G+ G C +P
Sbjct: 212 CNPGWKGPYCTE-PICLPGCDEQHGFCDKPG-----ECKCRVGWQGRYCDECIRYP---- 261
Query: 74 RPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSH-PCANGSTCT-TVANQFSCK 130
CL+G TC + ++C CQ G+ G C Q + C H PC NG+TCT T ++C
Sbjct: 262 -GCLHG-TC----QQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS 315
Query: 131 CLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSP 190
C G+TG CE ++ECD P C++GG+C +L SY C C GF G+ C+ + CA P
Sbjct: 316 CRPGYTGATCELGIDECD-PSPCKNGGSCTDLENSYSCTCPPGFYGKICELSAMTCADGP 374
Query: 191 CVNGGTCRQTGDFTFECNC 209
C NGG C + D + C C
Sbjct: 375 CFNGGRCSDSPDGGYSCRC 393
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 151 bits (381), Expect = 5e-37
Identities = 76/210 (36%), Positives = 103/210 (49%), Gaps = 10/210 (4%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
C+ C CP+G+ G C+ + C N C NGG+C + C C SG++G
Sbjct: 323 CINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSC--HEVPSGFECHCPSGWSGP 380
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGST 119
C S PC GGTC + D +EC C + G CQ + C PC N +
Sbjct: 381 TCALDIDE--CASNPCAAGGTC-VDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFS 437
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
C + + C C+ G+ G C +VN+C G CQHGGTC +L YQC C +GF G++C
Sbjct: 438 CKNLIGGYYCDCIPGWKGINCHINVNDCR--GQCQHGGTCKDLVNGYQCVCPRGFGGRHC 495
Query: 180 DSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
+ CA SPC +GG C D F C+C
Sbjct: 496 ELERDECASSPCHSGGLCEDLAD-GFHCHC 524
Score = 143 bits (361), Expect = 1e-34
Identities = 77/212 (36%), Positives = 100/212 (47%), Gaps = 8/212 (3%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
CV+ G C C GF G YC D C C+NGGTC+ + + C C SG+ GE
Sbjct: 612 CVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDE--VDAFRCFCPSGWEGE 669
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANGST 119
C + + C PC + G C+ L D Y C C G+ GK C + C ++ C+NG T
Sbjct: 670 LCD-TNPNDCLPD-PCHSRGRCYDLVNDFY-CACDDGWKGKTCHSREFQCDAYTCSNGGT 726
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
C + F C C G+ G C N +P C +GGTC+ S+ C C G+ G+ C
Sbjct: 727 CYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTC 786
Query: 180 DSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C P PC NGG C G F C C P
Sbjct: 787 THNTNDCNPLPCYNGGIC-VDGVNWFRCECAP 817
Score = 132 bits (332), Expect = 3e-31
Identities = 68/214 (31%), Positives = 103/214 (48%), Gaps = 15/214 (7%)
Query: 2 CVTYHNGT---GYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFT 58
C H G G C+C G+ G +C + C CV + + C C + +
Sbjct: 249 CNLLHGGCTVPGECRCSYGWQGRFC--------DECVPYPGCVHGSCVEPWQCNCETNWG 300
Query: 59 GEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANG 117
G C ++ C PC NGGTC D Y CTC G++G+ C+ + AC S+PCANG
Sbjct: 301 GLLCDKDLNY-CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANG 359
Query: 118 STCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQ 177
+C V + F C C +G++G C D++EC C GGTC++ ++C C + + G
Sbjct: 360 GSCHEVPSGFECHCPSGWSGPTCALDIDEC-ASNPCAAGGTCVDQVDGFECICPEQWVGA 418
Query: 178 YCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C C PC+N +C+ + C+C+P
Sbjct: 419 TCQLDANECEGKPCLNAFSCKNLIG-GYYCDCIP 451
Score = 122 bits (307), Expect = 2e-28
Identities = 60/174 (34%), Positives = 87/174 (50%), Gaps = 7/174 (4%)
Query: 11 YCKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
YC C +G+ G+ C R+ C+ C NGGTC + C C G+ G C + +
Sbjct: 697 YCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGDTFR--CACPPGWKGSTCAVAKNSS 754
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFS 128
C + PC+NGGTC + S ++ C C+ G+ G+ C T+ C PC NG C N F
Sbjct: 755 C-LPNPCVNGGTC-VGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFR 812
Query: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSL 182
C+C GF G C +++EC C +G TC++ Y+C C G G C +
Sbjct: 813 CECAPGFAGPDCRINIDECQ-SSPCAYGATCVDEINGYRCSCPPGRAGPRCQEV 865
Score = 119 bits (298), Expect = 2e-27
Identities = 73/226 (32%), Positives = 95/226 (42%), Gaps = 30/226 (13%)
Query: 8 GTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
G YC C G+ G C + +CQ+GGTC + ++ C C GF G C+
Sbjct: 443 GGYYCDCIPGWKGINCHINVNDCRGQCQHGGTC--KDLVNGYQCVCPRGFGGRHCELERD 500
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQ 126
S PC +GG C L+ D + C C GF+G C+ D C PC NG+ C +
Sbjct: 501 E--CASSPCHSGGLCEDLA-DGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGD 557
Query: 127 FSCKCLTGFTGQKCETDVNECD-----------------IPGHCQHG-----GTCLNLPG 164
+ C C F G+ C C +PG G G C++ PG
Sbjct: 558 YYCACPDDFGGKNCSVPREPCPGGACRVIDGCGSDAGPGMPGTAASGVCGPHGRCVSQPG 617
Query: 165 -SYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
++ C C GFTG YC C PC NGGTC D F C C
Sbjct: 618 GNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVD-AFRCFC 662
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 150 bits (380), Expect = 7e-37
Identities = 80/212 (37%), Positives = 103/212 (48%), Gaps = 8/212 (3%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
C + G C C +GF G YC + CE N C+NGGTC+ K C C+ G+ G
Sbjct: 605 CKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNSYK--CICSDGWEGA 662
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDA-CLSHPCANGST 119
C+ + + C PC NGGTC L D Y C C+ G+ GK C D+ C C NG T
Sbjct: 663 YCE-TNINDCS-QNPCHNGGTCRDLVNDFY-CDCKNGWKGKTCHSRDSQCDEATCNNGGT 719
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
C + F C C G+ G C N +P C +GGTC+ S+ C C +G+ G C
Sbjct: 720 CYDEGDAFKCMCPGGWEGTTCNIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPIC 779
Query: 180 DSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C+P PC N GTC GD + C C P
Sbjct: 780 AQNTNDCSPHPCYNSGTC-VDGDNWYRCECAP 810
Score = 144 bits (363), Expect = 7e-35
Identities = 70/203 (34%), Positives = 105/203 (51%), Gaps = 12/203 (5%)
Query: 10 GYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
G C+C G+ G YC ++C CV C C + + G+ C ++
Sbjct: 249 GDCRCQYGWQGLYC--------DKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNY- 299
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANGSTCTTVANQFS 128
C +PCLNGGTC D Y+C+C G++G C+ + ACLS PC N +C + F
Sbjct: 300 CGTHQPCLNGGTCSNTGPDKYQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFE 359
Query: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAP 188
C+C G+TG C T++++C P +C HGGTC +L ++C C +TG+ C C
Sbjct: 360 CECSPGWTGPTCSTNIDDCS-PNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEA 418
Query: 189 SPCVNGGTCRQTGDFTFECNCLP 211
PCVN +C+ ++ C+CLP
Sbjct: 419 KPCVNAKSCKNL-IASYYCDCLP 440
Score = 139 bits (350), Expect = 2e-33
Identities = 72/200 (36%), Positives = 105/200 (52%), Gaps = 10/200 (5%)
Query: 12 CKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C CPEG+ G C+ + C + C N G+C + LG C C+ G+TG C ST+
Sbjct: 322 CSCPEGYSGPNCEIAEHACLSDPCHNRGSC-KETSLG-FECECSPGWTGPTC--STNIDD 377
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFSC 129
C +GGTC L ++C C +TGK CQ + C + PC N +C + + C
Sbjct: 378 CSPNNCSHGGTCQDLVNG-FKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYC 436
Query: 130 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPS 189
CL G+ GQ C+ ++N+C G CQ+ +C +L Y+C C G+ G +C+ CA +
Sbjct: 437 DCLPGWMGQNCDININDC--LGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASN 494
Query: 190 PCVNGGTCRQTGDFTFECNC 209
PC+NGG C Q F+C C
Sbjct: 495 PCLNGGHC-QNEINRFQCLC 513
Score = 135 bits (341), Expect = 2e-32
Identities = 76/231 (32%), Positives = 110/231 (47%), Gaps = 16/231 (6%)
Query: 11 YCKCPEGFLGEYCQHRDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
YC C G+ G+ C RD C++ C NGGTC + K C C G+ G C + +
Sbjct: 690 YCDCKNGWKGKTCHSRDSQCDEATCNNGGTCYDEGDAFK--CMCPGGWEGTTCNIARNSS 747
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFS 128
C + PC NGGTC +++ +++ C C+ G+ G C Q T+ C HPC N TC N +
Sbjct: 748 C-LPNPCHNGGTC-VVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYR 805
Query: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAP 188
C+C GF G C ++NEC C G TC++ Y+C C G +G C + +
Sbjct: 806 CECAPGFAGPDCRININECQ-SSPCAFGATCVDEINGYRCVCPPGHSGAKCQEV----SG 860
Query: 189 SPCVNGGTCRQTG----DFTFECNCLPETVRRGTELWERDREVWNGKEHDE 235
PC+ G+ G D C CL + +++W R K H E
Sbjct: 861 RPCITMGSVIPDGAKWDDDCNTCQCLNGRI-ACSKVWCGPRPCLLHKGHSE 910
Score = 124 bits (312), Expect = 5e-29
Identities = 73/240 (30%), Positives = 100/240 (41%), Gaps = 43/240 (17%)
Query: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSH-- 68
C+C G+ G C D C N C +GGTC Q ++ C C +TG+ CQ +
Sbjct: 360 CECSPGWTGPTCSTNIDDCSPNNCSHGGTC--QDLVNGFKCVCPPQWTGKTCQLDANECE 417
Query: 69 --PCFVSRPCLN--------------GGTCHMLSRDT----------------YECTCQV 96
PC ++ C N G C + D Y C C
Sbjct: 418 AKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPP 477
Query: 97 GFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQH 155
G+ G C+ D C S+PC NG C N+F C C TGF+G C+ D++ C+ P CQ+
Sbjct: 478 GYAGDHCERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDYCE-PNPCQN 536
Query: 156 GGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVR 215
G C N Y C+C + + G+ C L C +PC +C N PE VR
Sbjct: 537 GAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSC----TVAMASNDTPEGVR 592
Score = 116 bits (291), Expect = 1e-26
Identities = 67/227 (29%), Positives = 96/227 (42%), Gaps = 34/227 (14%)
Query: 11 YCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
YC C G++G+ C +CQN +C + ++ C C G+ G+ C+
Sbjct: 435 YCDCLPGWMGQNCDININDCLGQCQNDASC--RDLVNGYRCICPPGYAGDHCERDIDE-- 490
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSC 129
S PCLNGG C + ++C C GF+G CQ D C +PC NG+ C A+ + C
Sbjct: 491 CASNPCLNGGHCQN-EINRFQCLCPTGFSGNLCQLDIDYCEPNPCQNGAQCYNRASDYFC 549
Query: 130 KCLTGFTGQKCE-----TDVNECDIPGHCQ----------------------HGGTCLNL 162
KC + G+ C C++ C HG
Sbjct: 550 KCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPHGKCKSQS 609
Query: 163 PGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
G + C C +GFTG YC C +PC NGGTC G +++C C
Sbjct: 610 GGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCID-GVNSYKCIC 655
Score = 68.6 bits (166), Expect = 5e-12
Identities = 66/253 (26%), Positives = 94/253 (37%), Gaps = 71/253 (28%)
Query: 7 NGTGY-CKCPEGFLGEYC-QHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQY 64
NG + C C EG+ G C Q+ + C + C N GTCV + C CA GF G DC+
Sbjct: 762 NGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYR--CECAPGFAGPDCRI 819
Query: 65 STSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-------------------W 105
+ + S PC G TC + + Y C C G +G +CQ W
Sbjct: 820 NINE--CQSSPCAFGATC-VDEINGYRCVCPPGHSGAKCQEVSGRPCITMGSVIPDGAKW 876
Query: 106 TDACLSHPCANGS-TCTTV-ANQFSCKCLTGFT----GQKC------ETDVNECDIPGHC 153
D C + C NG C+ V C G + GQ C + V+ C G C
Sbjct: 877 DDDCNTCQCLNGRIACSKVWCGPRPCLLHKGHSECPSGQSCIPILDDQCFVHPCTGVGEC 936
Query: 154 QHGG----------------TCLNLPGSYQCQCLQ-GFTGQY-CD--------------- 180
+ C N+ ++ + + G T ++ C
Sbjct: 937 RSSSLQPVKTKCTSDSYYQDNCANITFTFNKEMMSPGLTTEHICSELRNLNILKNVSAEY 996
Query: 181 SLYVPCAPSPCVN 193
S+Y+ C PSP N
Sbjct: 997 SIYIACEPSPSAN 1009
Score = 56.6 bits (135), Expect = 2e-08
Identities = 37/127 (29%), Positives = 49/127 (38%), Gaps = 18/127 (14%)
Query: 101 KECQWTDACLSH-PCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPG--HCQHG- 156
K C+ D H C T + +C Q C C +PG CQ+G
Sbjct: 198 KFCRPRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGW 257
Query: 157 -----GTCLNLPG--------SYQCQCLQGFTGQYCDSLYVPCAP-SPCVNGGTCRQTGD 202
C+ PG +QC C + GQ CD C PC+NGGTC TG
Sbjct: 258 QGLYCDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGP 317
Query: 203 FTFECNC 209
++C+C
Sbjct: 318 DKYQCSC 324
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 149 bits (377), Expect = 2e-36
Identities = 78/215 (36%), Positives = 109/215 (50%), Gaps = 10/215 (4%)
Query: 12 CKCPEGFLGEYCQHRDPCEKNRCQNGGTCV---AQAMLGKATCRCASGFTGEDCQYSTSH 68
C C E ++G +C+ D C++ CQN +C+ + TC C G+TGE CQ +
Sbjct: 336 CTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGELCQSKIDY 395
Query: 69 PCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQF 127
C + PC NG TC + S + C C G+ G C+ D C S PC N TC F
Sbjct: 396 -CILD-PCRNGATC-ISSLSGFTCQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGVHF 452
Query: 128 SCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCA 187
+C C GFTG C ++ C + C HG TC ++ SY+C C G+ G YC+ Y C
Sbjct: 453 TCNCSPGFTGPTCAQLIDFCAL-SPCAHG-TCRSVGTSYKCLCDPGYHGLYCEEEYNECL 510
Query: 188 PSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWE 222
+PC+N TCR + +EC CL E EL++
Sbjct: 511 SAPCLNAATCRDLVN-GYECVCLAEYKGTHCELYK 544
Score = 147 bits (372), Expect = 6e-36
Identities = 78/202 (38%), Positives = 103/202 (50%), Gaps = 10/202 (4%)
Query: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C C G+ GE CQ + D C + C+NG TC++ L TC+C G+ G C+ PC
Sbjct: 378 CVCLPGYTGELCQSKIDYCILDPCRNGATCISS--LSGFTCQCPEGYFGSACEEKVD-PC 434
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFSC 129
S PC N GTC++ + C C GFTG C Q D C PCA+G TC +V + C
Sbjct: 435 -ASSPCQNNGTCYV-DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHG-TCRSVGTSYKC 491
Query: 130 KCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPS 189
C G+ G CE + NEC + C + TC +L Y+C CL + G +C+ PCA
Sbjct: 492 LCDPGYHGLYCEEEYNEC-LSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANV 550
Query: 190 PCVNGGTCRQTGDFTFECNCLP 211
C+NG TC G C C P
Sbjct: 551 SCLNGATCDSDG-LNGTCICAP 571
Score = 144 bits (364), Expect = 5e-35
Identities = 73/206 (35%), Positives = 97/206 (47%), Gaps = 41/206 (19%)
Query: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC-------- 62
C+CPEG+ G C+ + DPC + CQN GTC + TC C+ GFTG C
Sbjct: 416 CQCPEGYFGSACEEKVDPCASSPCQNNGTCYVDGV--HFTCNCSPGFTGPTCAQLIDFCA 473
Query: 63 ----------QYSTSHPCF-----------------VSRPCLNGGTCHMLSRDTYECTCQ 95
TS+ C +S PCLN TC L YEC C
Sbjct: 474 LSPCAHGTCRSVGTSYKCLCDPGYHGLYCEEEYNECLSAPCLNAATCRDLVNG-YECVCL 532
Query: 96 VGFTGKECQ-WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQ 154
+ G C+ + D C + C NG+TC + +C C GFTG++C+ D+NECD C
Sbjct: 533 AEYKGTHCELYKDPCANVSCLNGATCDSDGLNGTCICAPGFTGEECDIDINECD-SNPCH 591
Query: 155 HGGTCLNLPGSYQCQCLQGFTGQYCD 180
HGG+CL+ P Y C C G+ G C+
Sbjct: 592 HGGSCLDQPNGYNCHCPHGWVGANCE 617
Score = 114 bits (285), Expect = 7e-26
Identities = 61/183 (33%), Positives = 85/183 (46%), Gaps = 11/183 (6%)
Query: 34 CQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC----HMLSRDT 89
C G C + +C C + G C+ + +PC N +C
Sbjct: 319 CSGKGKCTTKPSEATFSCTCEEQYVGTFCE---EYDACQRKPCQNNASCIDANEKQDGSN 375
Query: 90 YECTCQVGFTGKECQ-WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECD 148
+ C C G+TG+ CQ D C+ PC NG+TC + + F+C+C G+ G CE V+ C
Sbjct: 376 FTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVDPC- 434
Query: 149 IPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECN 208
CQ+ GTC + C C GFTG C L CA SPC + GTCR G +++C
Sbjct: 435 ASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSVGT-SYKCL 492
Query: 209 CLP 211
C P
Sbjct: 493 CDP 495
Score = 53.9 bits (128), Expect = 1e-07
Identities = 30/92 (32%), Positives = 42/92 (45%), Gaps = 16/92 (17%)
Query: 65 STSHPCFVSRPCLNGGTCHM-----------LSRDTYECTCQVGFTGKECQW-TDACLSH 112
S PC ++PC NGG C Y CTC G +G CQ D C S+
Sbjct: 43 SAPGPC-AAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASN 101
Query: 113 PCANG---STCTTVANQFSCKCLTGFTGQKCE 141
PC +G S+ ++ ++ + C C G+ G CE
Sbjct: 102 PCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 50.4 bits (119), Expect = 1e-06
Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 14/89 (15%)
Query: 28 PCEKNRCQNGGTCVAQ--------AMLGKA--TCRCASGFTGEDCQYSTSHPCFVSRPCL 77
PC C+NGG C ++ A G+ +C C +G +G +CQ + PC S PC
Sbjct: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQL-VADPC-ASNPCH 104
Query: 78 NG--GTCHMLSRDTYECTCQVGFTGKECQ 104
+G + S D Y C C G+ G C+
Sbjct: 105 HGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
Score = 45.1 bits (105), Expect = 5e-05
Identities = 26/96 (27%), Positives = 38/96 (39%), Gaps = 17/96 (17%)
Query: 109 CLSHPCANGSTCTTVANQ------------FSCKCLTGFTGQKCETDVNECDIPGHCQHG 156
C + PC NG CT+ +SC C G +G C+ + C C HG
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPC-ASNPCHHG 106
Query: 157 GTCLNLPGS---YQCQCLQGFTGQYCDSLYVPCAPS 189
+ S Y C C +G+ G C+ +P P+
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNCEQA-LPSLPA 141
Score = 38.9 bits (89), Expect = 0.004
Identities = 20/57 (35%), Positives = 26/57 (45%), Gaps = 3/57 (5%)
Query: 10 GY-CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKA-TCRCASGFTGEDCQ 63
GY C CP G G CQ DPC N C +G + + C C G+ G +C+
Sbjct: 77 GYSCTCPAGISGANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCE 133
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 145 bits (366), Expect = 3e-35
Identities = 84/234 (35%), Positives = 112/234 (47%), Gaps = 38/234 (16%)
Query: 8 GTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRC-ASGFTGEDCQYS 65
G +C C GFLG++C+ + D C C +GG CV + +C C SGFTG C+
Sbjct: 244 GAYFCDCAPGFLGDHCELNTDECASQPCLHGGLCVDGE--NRYSCNCTGSGFTGTHCE-- 299
Query: 66 TSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVA 124
T P S+PC N TC S D Y C C G+TG +C+ + C S+PC + C ++
Sbjct: 300 TLMPLCWSKPCHNNATCED-SVDNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELS 358
Query: 125 NQ--------------------FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPG 164
++ + C C GFTG CE DVNEC CQ+GGTC NLPG
Sbjct: 359 SEKQYGRITGLPSSFSYHEASGYVCICQPGFTGIHCEEDVNECS-SNPCQNGGTCENLPG 417
Query: 165 SYQCQC------LQGFTGQYCDSLYVPCAPSPCVNGGTC---RQTGDFTFECNC 209
+Y C C + G+ C + + C C+N GTC Q G F C C
Sbjct: 418 NYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLC 471
Score = 145 bits (365), Expect = 4e-35
Identities = 82/220 (37%), Positives = 107/220 (48%), Gaps = 30/220 (13%)
Query: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C CP + G C+ D C C NG TC Q LG C CA GF G+ C+ +T
Sbjct: 210 CICPHNYSGVNCELEIDECWSQPCLNGATC--QDALGAYFCDCAPGFLGDHCELNTDE-- 265
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQ-VGFTGKECQWT-DACLSHPCANGSTCTTVANQFS 128
S+PCL+GG C + + Y C C GFTG C+ C S PC N +TC + ++
Sbjct: 266 CASQPCLHGGLC-VDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSVDNYT 324
Query: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCL------------NLPGS--------YQC 168
C C G+TG +CE D+NEC+ CQ G C+ LP S Y C
Sbjct: 325 CHCWPGYTGAQCEIDLNECN-SNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVC 383
Query: 169 QCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQ-TGDFTFEC 207
C GFTG +C+ C+ +PC NGGTC G++T C
Sbjct: 384 ICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHC 423
Score = 134 bits (338), Expect = 5e-32
Identities = 68/194 (35%), Positives = 98/194 (50%), Gaps = 14/194 (7%)
Query: 23 CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC 82
C + C N C +GG C + + C C G++G+ C+ + CF S PC++G
Sbjct: 1137 CLQLNVCNSNPCLHGGNC--EDIYSSYHCSCPLGWSGKHCELNIDE-CF-SNPCIHGNCS 1192
Query: 83 HMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCE 141
++ Y CTC+ G+TG C+ D C SH CANG+TC + N +SC C FTG+ C
Sbjct: 1193 DRVA--AYHCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCR 1250
Query: 142 TDVNECDIPGH------CQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGG 195
+ G+ C +GG C +C C GFTG++C+ CA PCVNGG
Sbjct: 1251 QSRLPSTVCGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGG 1310
Query: 196 TCRQTGDFTFECNC 209
C+ + F+C C
Sbjct: 1311 LCQDLLN-KFQCLC 1323
Score = 126 bits (317), Expect = 1e-29
Identities = 70/205 (34%), Positives = 100/205 (48%), Gaps = 11/205 (5%)
Query: 12 CKCPE--GFLGEYCQH-RDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSH 68
C C + L + C + +DPC N CQ TCV C+C G++G C+ +T
Sbjct: 54 CSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERSFLCKCPPGYSGTICE-TTIG 112
Query: 69 PCFVSRPCLNGGTCHMLSRDTYE-CTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQ 126
C C +GG CH Y C C G+ G+ C+ D C S PC NG+ C +
Sbjct: 113 SCG-KNSCQHGGICHQ--DPIYPVCICPAGYAGRFCEIDHDECASSPCQNGAVCQDGIDG 169
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPC 186
+SC C+ G+ G+ C+ +V+EC C++ TCLN G Y C C ++G C+ C
Sbjct: 170 YSCFCVPGYQGRHCDLEVDEC-ASDPCKNEATCLNEIGRYTCICPHNYSGVNCELEIDEC 228
Query: 187 APSPCVNGGTCRQTGDFTFECNCLP 211
PC+NG TC+ F C+C P
Sbjct: 229 WSQPCLNGATCQDALGAYF-CDCAP 252
Score = 107 bits (267), Expect = 9e-24
Identities = 58/179 (32%), Positives = 85/179 (47%), Gaps = 16/179 (8%)
Query: 11 YCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
+C CP G+ G++C+ + D C N C +G + C C G+TG +C+ +
Sbjct: 1162 HCSCPLGWSGKHCELNIDECFSNPCIHGN---CSDRVAAYHCTCEPGYTGVNCEVDIDN- 1217
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT--------DACLSHPCANGSTCT 121
S C NG TC + + Y C C FTGK C+ + + + C NG CT
Sbjct: 1218 -CQSHQCANGATC-ISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTCYNGGNCT 1275
Query: 122 TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
+ C C GFTG+ CE D++EC C +GG C +L +QC C F G+ C+
Sbjct: 1276 EFQTELKCMCRPGFTGEWCEKDIDEC-ASDPCVNGGLCQDLLNKFQCLCDVAFAGERCE 1333
Score = 100 bits (250), Expect = 8e-22
Identities = 53/145 (36%), Positives = 71/145 (48%), Gaps = 8/145 (5%)
Query: 72 VSRPCLNGGTCHMLSRDTYECTCQ--VGFTGKECQ-WTDACLSHPCANGSTCTTVANQ-- 126
+S C N TC S+D +C+C K+C D C S+PC +TC +
Sbjct: 35 LSNSCQNNSTCKDFSKDN-DCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVNTPGERS 93
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPC 186
F CKC G++G CET + C CQHGG C P C C G+ G++C+ + C
Sbjct: 94 FLCKCPPGYSGTICETTIGSCG-KNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDEC 152
Query: 187 APSPCVNGGTCRQTGDFTFECNCLP 211
A SPC NG C Q G + C C+P
Sbjct: 153 ASSPCQNGAVC-QDGIDGYSCFCVP 176
Score = 98.2 bits (243), Expect = 5e-21
Identities = 50/141 (35%), Positives = 72/141 (51%), Gaps = 10/141 (7%)
Query: 11 YCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST--S 67
+C C G+ G C+ D C+ ++C NG TC++ +C C FTG+ C+ S S
Sbjct: 1199 HCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHT--NGYSCLCFGNFTGKFCRQSRLPS 1256
Query: 68 HPCFVSRP---CLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTV 123
C + C NGG C + +C C+ GFTG+ C+ D C S PC NG C +
Sbjct: 1257 TVCGNEKTNLTCYNGGNCTEFQTEL-KCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDL 1315
Query: 124 ANQFSCKCLTGFTGQKCETDV 144
N+F C C F G++CE D+
Sbjct: 1316 LNKFQCLCDVAFAGERCEVDL 1336
Score = 71.2 bits (173), Expect = 7e-13
Identities = 49/160 (30%), Positives = 65/160 (40%), Gaps = 33/160 (20%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCV---AQAMLGKAT---------------CR 52
C C G+ G C+ + C N CQ+ G CV ++ G+ T C
Sbjct: 325 CHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASGYVCI 384
Query: 53 CASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTC------QVGFTGKECQ-W 105
C GFTG C+ + S PC NGGTC L + Y C C + + G++C
Sbjct: 385 CQPGFTGIHCEEDVNECS--SNPCQNGGTCENLPGN-YTCHCPFDNLSRTFYGGRDCSDI 441
Query: 106 TDACLSHPCANGSTCTTVANQ----FSCKCLTGFTGQKCE 141
C C N TC FSC C +G+TG CE
Sbjct: 442 LLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCE 481
Score = 53.5 bits (127), Expect = 2e-07
Identities = 27/67 (40%), Positives = 33/67 (49%), Gaps = 3/67 (4%)
Query: 73 SRPCLNGGTCHMLSR-DTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKC 131
S PC NGG CH SR D + C+C +GK C+ C PC +G+ C V F C
Sbjct: 893 SNPCHNGGVCH--SRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQPVLQGFECIA 950
Query: 132 LTGFTGQ 138
F GQ
Sbjct: 951 NAVFNGQ 957
Score = 50.8 bits (120), Expect = 1e-06
Identities = 31/103 (30%), Positives = 45/103 (43%), Gaps = 9/103 (8%)
Query: 103 CQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNL 162
C ++C S+PC NG C + + FSC C +G+ CE +V C C HG C +
Sbjct: 885 CAGDNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGF-SPCPHGAQCQPV 942
Query: 163 PGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTF 205
++C F GQ L+ NG R+ + TF
Sbjct: 943 LQGFECIANAVFNGQSGQILFRS-------NGNITRELTNITF 978
Score = 42.0 bits (97), Expect = 5e-04
Identities = 30/112 (26%), Positives = 39/112 (34%), Gaps = 48/112 (42%)
Query: 4 TYHNGTGY-CKCPEGFLGEYCQHR-DPCEKNRCQNGGTC--------------------- 40
+YH +GY C C GF G +C+ + C N CQNGGTC
Sbjct: 374 SYHEASGYVCICQPGFTGIHCEEDVNECSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFY 433
Query: 41 ------------VAQAMLGKATC-------------RCASGFTGEDCQYSTS 67
Q L TC C SG+TG C+ +T+
Sbjct: 434 GGRDCSDILLGCTHQQCLNNGTCIPHFQDGQHGFSCLCPSGYTGSLCEIATT 485
Score = 36.2 bits (82), Expect = 0.025
Identities = 23/82 (28%), Positives = 36/82 (43%), Gaps = 6/82 (7%)
Query: 23 CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC 82
C + C+ N C NGG C + +C C + +G+ C+ C S PC +G C
Sbjct: 885 CAGDNSCKSNPCHNGGVC--HSRWDDFSCSCPALTSGKACE--EVQWCGFS-PCPHGAQC 939
Query: 83 HMLSRDTYECTCQVGFTGKECQ 104
+ + +EC F G+ Q
Sbjct: 940 QPVLQG-FECIANAVFNGQSGQ 960
Score = 33.9 bits (76), Expect = 0.13
Identities = 15/32 (46%), Positives = 18/32 (56%)
Query: 153 CQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYV 184
CQ G C+NL SYQC C + + G C YV
Sbjct: 681 CQSRGRCINLWLSYQCDCHRPYEGPNCLREYV 712
Score = 28.5 bits (62), Expect = 5.3
Identities = 11/38 (28%), Positives = 15/38 (39%)
Query: 103 CQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKC 140
C D C S PC + C + + C C + G C
Sbjct: 670 CVRKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 27.7 bits (60), Expect = 9.0
Identities = 12/40 (30%), Positives = 18/40 (45%), Gaps = 2/40 (5%)
Query: 23 CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC 62
C +D CE CQ+ G C+ + C C + G +C
Sbjct: 670 CVRKDWCESQPCQSRGRCINLWL--SYQCDCHRPYEGPNC 707
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 145 bits (365), Expect = 4e-35
Identities = 78/204 (38%), Positives = 99/204 (48%), Gaps = 11/204 (5%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C C G+ G C+ C+ N C+NGG+C Q C C G+ G C++ST
Sbjct: 310 CTCRPGYTGVDCELELSECDSNPCRNGGSCKDQE--DGYHCLCPPGYYGLHCEHSTLS-- 365
Query: 71 FVSRPCLNGGTCHMLSRDT-YECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFS 128
PC NGG+C ++ Y C C FTG C+ D C S+PCANG C
Sbjct: 366 CADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPSRM 425
Query: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD--SLYVPC 186
C+C GFTG CE V++C C HGGTC +L C C GF+G+ C+ + C
Sbjct: 426 CRCRPGFTGTYCELHVSDC-ARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDAC 484
Query: 187 APSPCVNGGTC-RQTGDFTFECNC 209
A SPC N TC TF CNC
Sbjct: 485 ASSPCFNRATCYTDLSTDTFVCNC 508
Score = 141 bits (355), Expect = 6e-34
Identities = 78/197 (39%), Positives = 98/197 (49%), Gaps = 22/197 (11%)
Query: 12 CKCPEGFLG-------EYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQY 64
C C EG+ G YC H PC+ NG TC + + TC C G+TG DC+
Sbjct: 270 CTCDEGWGGLFCDQDLNYCTHHSPCK-----NGATC-SNSGQRSYTCTCRPGYTGVDCEL 323
Query: 65 STSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTV 123
S S PC NGG+C D Y C C G+ G C+ T +C PC NG +C
Sbjct: 324 ELSE--CDSNPCRNGGSCKD-QEDGYHCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRE- 379
Query: 124 ANQ---FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
NQ ++C+C FTG CE V+ C C +GG CLN S C+C GFTG YC+
Sbjct: 380 RNQGANYACECPPNFTGSNCEKKVDRCT-SNPCANGGQCLNRGPSRMCRCRPGFTGTYCE 438
Query: 181 SLYVPCAPSPCVNGGTC 197
CA +PC +GGTC
Sbjct: 439 LHVSDCARNPCAHGGTC 455
Score = 123 bits (309), Expect = 1e-28
Identities = 73/216 (33%), Positives = 96/216 (44%), Gaps = 22/216 (10%)
Query: 6 HNGTGYCK------CPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTG 59
H GYC C G+ G C P N C++G TC C C G+ G
Sbjct: 227 HEQNGYCSKPAECLCRPGWQGRLCNECIP--HNGCRHG-TCSTPWQ-----CTCDEGWGG 278
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGS 118
C ++ C PC NG TC + +Y CTC+ G+TG +C+ C S+PC NG
Sbjct: 279 LFCDQDLNY-CTHHSPCKNGATCSNSGQRSYTCTCRPGYTGVDCELELSECDSNPCRNGG 337
Query: 119 TCTTVANQFSCKCLTGFTGQKCETDVNEC-DIPGHCQHGGTCL--NLPGSYQCQCLQGFT 175
+C + + C C G+ G CE C D P C +GG+C N +Y C+C FT
Sbjct: 338 SCKDQEDGYHCLCPPGYYGLHCEHSTLSCADSP--CFNGGSCRERNQGANYACECPPNFT 395
Query: 176 GQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
G C+ C +PC NGG C G C C P
Sbjct: 396 GSNCEKKVDRCTSNPCANGGQCLNRGPSRM-CRCRP 430
Score = 121 bits (304), Expect = 5e-28
Identities = 70/206 (33%), Positives = 100/206 (48%), Gaps = 21/206 (10%)
Query: 10 GYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
G C G+ GEYCQ + C + G C A C C G+ G C +
Sbjct: 204 GNLSCLPGWTGEYCQ-QPICLSGCHEQNGYCSKPA-----ECLCRPGWQGRLC-----NE 252
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSH-PCANGSTCTTVANQ- 126
C C +G TC ++CTC G+ G C Q + C H PC NG+TC+ +
Sbjct: 253 CIPHNGCRHG-TCST----PWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRS 307
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPC 186
++C C G+TG CE +++ECD C++GG+C + Y C C G+ G +C+ + C
Sbjct: 308 YTCTCRPGYTGVDCELELSECD-SNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTLSC 366
Query: 187 APSPCVNGGTCRQTGD-FTFECNCLP 211
A SPC NGG+CR+ + C C P
Sbjct: 367 ADSPCFNGGSCRERNQGANYACECPP 392
Score = 114 bits (286), Expect = 6e-26
Identities = 61/177 (34%), Positives = 85/177 (48%), Gaps = 12/177 (6%)
Query: 11 YCKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
+C CP G+ G +C+H C + C NGG+C + C C FTG +C+
Sbjct: 347 HCLCPPGYYGLHCEHSTLSCADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDR- 405
Query: 70 CFVSRPCLNGGTCHMLSRDTYE-CTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQF 127
S PC NGG C L+R C C+ GFTG C+ C +PCA+G TC + N
Sbjct: 406 -CTSNPCANGGQC--LNRGPSRMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGL 462
Query: 128 SCKCLTGFTGQKCE--TDVNECDIPGHCQHGGTCLN--LPGSYQCQCLQGFTGQYCD 180
C C GF+G++CE T ++ C C + TC ++ C C GF G C+
Sbjct: 463 MCTCPAGFSGRRCEVRTSIDAC-ASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCE 518
Score = 110 bits (274), Expect = 1e-24
Identities = 60/150 (40%), Positives = 74/150 (49%), Gaps = 12/150 (8%)
Query: 2 CVTYHNGTGY-CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTG 59
C + G Y C+CP F G C+ + D C N C NGG C+ + CRC GFTG
Sbjct: 377 CRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGP--SRMCRCRPGFTG 434
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT---DACLSHPCAN 116
C+ S PC +GGTCH L CTC GF+G+ C+ DAC S PC N
Sbjct: 435 TYCELHVSD--CARNPCAHGGTCHDLENGLM-CTCPAGFSGRRCEVRTSIDACASSPCFN 491
Query: 117 GSTCTT--VANQFSCKCLTGFTGQKCETDV 144
+TC T + F C C GF G +CE V
Sbjct: 492 RATCYTDLSTDTFVCNCPYGFVGSRCEFPV 521
Score = 48.5 bits (114), Expect = 5e-06
Identities = 24/71 (33%), Positives = 28/71 (39%), Gaps = 4/71 (5%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHR---DPCEKNRCQNGGTCVAQAMLGKATCRCASGFT 58
C NG C CP GF G C+ R D C + C N TC C C GF
Sbjct: 455 CHDLENGL-MCTCPAGFSGRRCEVRTSIDACASSPCFNRATCYTDLSTDTFVCNCPYGFV 513
Query: 59 GEDCQYSTSHP 69
G C++ P
Sbjct: 514 GSRCEFPVGLP 524
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 143 bits (360), Expect = 1e-34
Identities = 76/207 (36%), Positives = 107/207 (51%), Gaps = 10/207 (4%)
Query: 8 GTGY-CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYS 65
G GY C CP G+ G C+ D C C N G C + ++G+ C C SG+TG+ C+ +
Sbjct: 1212 GRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVC--KDLVGEFICECPSGYTGQRCEEN 1269
Query: 66 TSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVA 124
+ S PCLN G C + Y CTC GF G C+ + C S+PC N + C
Sbjct: 1270 INECS--SSPCLNKGIC-VDGVAGYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQV 1326
Query: 125 NQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYV 184
F CKC GF G +C +V+EC + C++G TC + S++C C GFTG +C+
Sbjct: 1327 GGFLCKCPPGFLGTRCGKNVDEC-LSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNIN 1385
Query: 185 PCAPSPCVNGGTCRQTGDFTFECNCLP 211
C +PC N TC + ++ C C P
Sbjct: 1386 ECQSNPCRNQATCVDELN-SYSCKCQP 1411
Score = 132 bits (331), Expect = 3e-31
Identities = 66/176 (37%), Positives = 89/176 (50%), Gaps = 8/176 (4%)
Query: 8 GTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
G C+CP G+ G+ C+ + C + C N G CV + C C GF G C+
Sbjct: 1251 GEFICECPSGYTGQRCEENINECSSSPCLNKGICVDG--VAGYRCTCVKGFVGLHCETEV 1308
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVAN 125
+ S PCLN C + C C GF G C + D CLS PC NG+TC AN
Sbjct: 1309 NE--CQSNPCLNNAVCED-QVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGAN 1365
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDS 181
F C C GFTG CE ++NEC C++ TC++ SY C+C GF+G+ C++
Sbjct: 1366 SFRCLCAAGFTGSHCELNINECQ-SNPCRNQATCVDELNSYSCKCQPGFSGKRCET 1420
Score = 123 bits (308), Expect = 2e-28
Identities = 57/146 (39%), Positives = 81/146 (55%), Gaps = 7/146 (4%)
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQ 126
H CF + PC N GTC L R Y C C +G+TG +C+ D C PC N C + +
Sbjct: 1195 HECFFN-PCHNSGTCQQLGRG-YVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGE 1252
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPC 186
F C+C +G+TGQ+CE ++NEC C + G C++ Y+C C++GF G +C++ C
Sbjct: 1253 FICECPSGYTGQRCEENINECS-SSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNEC 1311
Query: 187 APSPCVNGGTCR-QTGDFTFECNCLP 211
+PC+N C Q G F C C P
Sbjct: 1312 QSNPCLNNAVCEDQVGGFL--CKCPP 1335
Score = 108 bits (270), Expect = 4e-24
Identities = 53/137 (38%), Positives = 76/137 (55%), Gaps = 8/137 (5%)
Query: 10 GY-CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
GY C C +GF+G +C+ + C+ N C N C Q +G C+C GF G C +
Sbjct: 1290 GYRCTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQ--VGGFLCKCPPGFLGTRCGKNVD 1347
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQ 126
+S+PC NG TC +++ C C GFTG C+ + C S+PC N +TC N
Sbjct: 1348 E--CLSQPCKNGATCKD-GANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNS 1404
Query: 127 FSCKCLTGFTGQKCETD 143
+SCKC GF+G++CET+
Sbjct: 1405 YSCKCQPGFSGKRCETE 1421
Score = 64.7 bits (156), Expect = 7e-11
Identities = 37/105 (35%), Positives = 49/105 (46%), Gaps = 16/105 (15%)
Query: 75 PCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTG 134
PC NGG C + C+C G+ G+ C+ L PC NG C + C C G
Sbjct: 3475 PCQNGGICQRPNA----CSCPEGWMGRLCEEPICIL--PCLNGGRCVA---PYQCDCPPG 3525
Query: 135 FTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
+TG +C T V C P C +GG C+ +C CL +TG C
Sbjct: 3526 WTGSRCHTAV--CQSP--CLNGGKCVR---PNRCHCLSSWTGHNC 3563
Score = 64.3 bits (155), Expect = 9e-11
Identities = 63/241 (26%), Positives = 82/241 (34%), Gaps = 60/241 (24%)
Query: 12 CK-CPEGFLGEYCQHRDPCE-KNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
CK CP G EY R+ + K +C+ G + G TC E C T P
Sbjct: 1032 CKLCPSGMYTEYIHSRNISDCKAQCKQG----TYSYSGLETC--------ESCPLGTYQP 1079
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLS-----HPCANGSTCTTVA 124
F SR CL +C + + G C S HPC
Sbjct: 1080 KFGSRSCL---SCPENTSTVKRGAVNISACGVPCPEGKFSRSGLMPCHPCPRDYYQPNAG 1136
Query: 125 NQFSCKC----LTGFTGQKCETD----------VNECDIP----GH-------------- 152
F C T F G + T+ E +P GH
Sbjct: 1137 KAFCLACPFYGTTPFAGSRSITECSSFSSTFSAAEESVVPPASLGHIKKRHEISSQVFHE 1196
Query: 153 -----CQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQ-TGDFTFE 206
C + GTC L Y C C G+TG C++ C+P PC+N G C+ G+F E
Sbjct: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFICE 1256
Query: 207 C 207
C
Sbjct: 1257 C 1257
Score = 62.4 bits (150), Expect = 3e-10
Identities = 43/136 (31%), Positives = 57/136 (41%), Gaps = 26/136 (19%)
Query: 84 MLSRDTYECTCQVGFTGKEC----QWTD-----ACLSHPCANGSTCTTVANQFSCKCLTG 134
M++ Y GF C WT A PC NG C +C C G
Sbjct: 3437 MITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVCRFPCQNGGICQ---RPNACSCPEG 3493
Query: 135 FTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNG 194
+ G+ CE + C +P C +GG C+ YQC C G+TG C + SPC+NG
Sbjct: 3494 WMGRLCEEPI--CILP--CLNGGRCV---APYQCDCPPGWTGSRC---HTAVCQSPCLNG 3543
Query: 195 GTCRQTGDFTFECNCL 210
G C + C+CL
Sbjct: 3544 GKCVRPN----RCHCL 3555
Score = 62.0 bits (149), Expect = 4e-10
Identities = 35/92 (38%), Positives = 42/92 (45%), Gaps = 16/92 (17%)
Query: 12 CKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCF 71
C CPEG++G C+ +P C NGG CVA C C G+TG C H
Sbjct: 3488 CSCPEGWMGRLCE--EPICILPCLNGGRCVAPYQ-----CDCPPGWTGSRC-----HTAV 3535
Query: 72 VSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC 103
PCLNGG C +R C C +TG C
Sbjct: 3536 CQSPCLNGGKCVRPNR----CHCLSSWTGHNC 3563
Score = 48.9 bits (115), Expect = 4e-06
Identities = 21/57 (36%), Positives = 33/57 (57%), Gaps = 3/57 (5%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
C C GF G +C+ + + C+ N C+N TCV + L +C+C GF+G+ C+ S
Sbjct: 1369 CLCAAGFTGSHCELNINECQSNPCRNQATCVDE--LNSYSCKCQPGFSGKRCETEQS 1423
Score = 41.6 bits (96), Expect = 6e-04
Identities = 29/108 (26%), Positives = 44/108 (40%), Gaps = 8/108 (7%)
Query: 76 CLNGGTCHMLSRDTYECTCQV------GFTGKECQWTDACLSHPCANGSTCTTVANQFSC 129
CLN G +C V GF + + + +++ C NG + F C
Sbjct: 1672 CLNQGQWTQPLPHCERISCGVPPPLENGFHSADDFYAGSTVTYQCNNGYYLLGDSRMF-C 1730
Query: 130 KCLTGFTGQKCET-DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTG 176
+ G DV+EC + C +CLN+ GSY C C+ +TG
Sbjct: 1731 TDNGSWNGVSPSCLDVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG 1778
Score = 33.5 bits (75), Expect = 0.16
Identities = 31/130 (23%), Positives = 48/130 (36%), Gaps = 23/130 (17%)
Query: 22 YCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYS-TSHPCFVSRP----- 75
+C + K+ C G+C G C C G+ G+ QY T+ P +P
Sbjct: 276 HCSYLCDEGKDCCDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPG 335
Query: 76 ----CL----NGGTCHMLSRDTYECTCQVGF--TGKECQWTDACLSHPCANG----STCT 121
C+ T S +C C+ G+ +G+ C+ P NG +TC
Sbjct: 336 GISSCIPCPDENHTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCN 395
Query: 122 TVANQFSCKC 131
N F+ C
Sbjct: 396 ---NHFNAAC 402
Score = 30.8 bits (68), Expect = 1.1
Identities = 27/108 (25%), Positives = 43/108 (39%), Gaps = 19/108 (17%)
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHG-----GTCL--------NLPGS- 165
C T F C C G+ G+ + + C + G +C+ + PGS
Sbjct: 296 CGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDENHTSPPGST 355
Query: 166 --YQCQCLQGF--TGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
C C +G+ +GQ C+ ++ P A P NG + T + F C
Sbjct: 356 SPEDCVCREGYRASGQTCELVHCP-ALKPPENGYFIQNTCNNHFNAAC 402
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 141 bits (356), Expect = 4e-34
Identities = 74/198 (37%), Positives = 101/198 (51%), Gaps = 10/198 (5%)
Query: 9 TGY-CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
TG+ C C GF G C+ D C C +G TC + + + C C G+ G C+
Sbjct: 90 TGFRCYCVPGFQGPRCELDIDECASRPCHHGATC--RNLADRYECHCPLGYAGVTCEMEV 147
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVAN 125
S PCL+GG+C + ++ C C G+ G CQ D C S PCA+G TC + N
Sbjct: 148 DE--CASAPCLHGGSC-LDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVN 204
Query: 126 QFSCKCL-TGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYV 184
F C C TG+ G CE +V EC C+H +CL GS++C C G++G+ C+
Sbjct: 205 GFRCDCAGTGYEGTHCEREVLEC-ASAPCEHNASCLEGLGSFRCLCWPGYSGELCEVDED 263
Query: 185 PCAPSPCVNGGTCRQTGD 202
CA SPC +GG C Q D
Sbjct: 264 ECASSPCQHGGRCLQRSD 281
Score = 117 bits (293), Expect = 9e-27
Identities = 76/263 (28%), Positives = 104/263 (39%), Gaps = 68/263 (25%)
Query: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C CP G+ G C+ D C C +GG+C+ +G C CA G+ G CQ
Sbjct: 132 CHCPLGYAGVTCEMEVDECASAPCLHGGSCLDG--VGSFRCVCAPGYGGTRCQLDLDE-- 187
Query: 71 FVSRPCLNGGTCHMLSRD--------------------------------------TYEC 92
S+PC +GGTCH L ++ C
Sbjct: 188 CQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRC 247
Query: 93 TCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQ---------------------FSCK 130
C G++G+ C+ D C S PC +G C ++ F C
Sbjct: 248 LCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCH 307
Query: 131 CLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSP 190
C GF G C +V+EC C +GG C +LP +QC C G+ G C+ C P
Sbjct: 308 CPPGFEGADCGVEVDEC-ASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDECLSDP 366
Query: 191 CVNGGTCRQTGDFTFECNCLPET 213
C++GGTC T + C C PET
Sbjct: 367 CLHGGTCSDT-VAGYICRC-PET 387
Score = 115 bits (287), Expect = 4e-26
Identities = 69/228 (30%), Positives = 96/228 (42%), Gaps = 31/228 (13%)
Query: 12 CKCP-EGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
C C G+ G +C+ C C++ +C+ LG C C G++GE C+
Sbjct: 208 CDCAGTGYEGTHCEREVLECASAPCEHNASCLEG--LGSFRCLCWPGYSGELCEVDEDE- 264
Query: 70 CFVSRPCLNGGTCHMLSRDT--------------------YECTCQVGFTGKECQW-TDA 108
S PC +GG C S + C C GF G +C D
Sbjct: 265 -CASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFEGADCGVEVDE 323
Query: 109 CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQC 168
C S PC NG C + N F C C G+ G CE DV+EC + C HGGTC + Y C
Sbjct: 324 CASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCEEDVDEC-LSDPCLHGGTCSDTVAGYIC 382
Query: 169 QCLQGFTGQYCDSLYVPCAPSPCVNGGTC---RQTGDFTFECNCLPET 213
+C + + G+ C C C TC ++G ++ C+C P T
Sbjct: 383 RCPETWGGRDCSVQLTGCQGHTCPLAATCIPIFESGVHSYVCHCPPGT 430
Score = 111 bits (277), Expect = 6e-25
Identities = 61/184 (33%), Positives = 86/184 (46%), Gaps = 18/184 (9%)
Query: 29 CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRD 88
C + C G C A + G+T C C ++PC +G C D
Sbjct: 42 CASDPCAPGTECQATE---------SGGYT---CGPMEPRGC-ATQPCHHGALCVPQGPD 88
Query: 89 T--YECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVN 145
+ C C GF G C+ D C S PC +G+TC +A+++ C C G+ G CE +V+
Sbjct: 89 PTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVD 148
Query: 146 ECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTF 205
EC C HGG+CL+ GS++C C G+ G C C PC +GGTC + F
Sbjct: 149 EC-ASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVN-GF 206
Query: 206 ECNC 209
C+C
Sbjct: 207 RCDC 210
Score = 107 bits (266), Expect = 1e-23
Identities = 55/144 (38%), Positives = 69/144 (47%), Gaps = 5/144 (3%)
Query: 69 PCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-WTDACLSHPCANGSTCTTVANQF 127
P PCL+ G C L D + C C G+ G C+ D C S PCA G T +F
Sbjct: 1058 PVCAPSPCLHDGACRDLF-DAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRF 1116
Query: 128 SCKCLTGFTGQKCETDV--NECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
C+C GF G +C V EC + C G C + C CL+G GQ C +P
Sbjct: 1117 ECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLP 1176
Query: 186 CAPSPCVNGGTCRQTGDFTFECNC 209
C +PC+NGGTCR G + EC C
Sbjct: 1177 CEANPCLNGGTCRAAGGVS-ECIC 1199
Score = 105 bits (262), Expect = 3e-23
Identities = 64/198 (32%), Positives = 86/198 (43%), Gaps = 31/198 (15%)
Query: 8 GTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQ---AMLGKAT------------- 50
G+ C C G+ GE C+ D C + CQ+GG C+ + A+ G
Sbjct: 243 GSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAA 302
Query: 51 ---CRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-T 106
C C GF G DC SRPCLNGG C L ++C C G+ G C+
Sbjct: 303 GFLCHCPPGFEGADCGVEVDE--CASRPCLNGGHCQDLPNG-FQCHCPDGYAGPTCEEDV 359
Query: 107 DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGH-CQHGGTCLNL--- 162
D CLS PC +G TC+ + C+C + G+ C + C GH C TC+ +
Sbjct: 360 DECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQ--GHTCPLAATCIPIFES 417
Query: 163 -PGSYQCQCLQGFTGQYC 179
SY C C G G +C
Sbjct: 418 GVHSYVCHCPPGTHGPFC 435
Score = 92.4 bits (228), Expect = 3e-19
Identities = 46/127 (36%), Positives = 63/127 (49%), Gaps = 17/127 (13%)
Query: 100 GKECQWTDA------------CLSHPCANGSTCTTVANQ---FSCKCLTGFTGQKCETDV 144
G ECQ T++ C + PC +G+ C F C C+ GF G +CE D+
Sbjct: 50 GTECQATESGGYTCGPMEPRGCATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDI 109
Query: 145 NECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFT 204
+EC C HG TC NL Y+C C G+ G C+ CA +PC++GG+C G +
Sbjct: 110 DEC-ASRPCHHGATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLD-GVGS 167
Query: 205 FECNCLP 211
F C C P
Sbjct: 168 FRCVCAP 174
Score = 90.5 bits (223), Expect = 1e-18
Identities = 53/170 (31%), Positives = 75/170 (44%), Gaps = 12/170 (7%)
Query: 15 PEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSR 74
P LG C+ C + C + G C + + C C G+ G C+ PC S
Sbjct: 1048 PAPILG--CRGAPVCAPSPCLHDGAC--RDLFDAFACACGPGWEGPRCEAHVD-PCH-SA 1101
Query: 75 PCLNGGTCHMLSRDTYECTCQVGFTGKECQWT----DACLSHPCANGSTCTTVANQFSCK 130
PC G CH +EC C GF G C+ + L+ C +GS C + +C
Sbjct: 1102 PCARG-RCHTHPDGRFECRCPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCS 1160
Query: 131 CLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
CL G GQ+C+ C+ C +GGTC G +C C F+GQ+C+
Sbjct: 1161 CLEGLAGQRCQVPTLPCEA-NPCLNGGTCRAAGGVSECICNARFSGQFCE 1209
Score = 80.1 bits (196), Expect = 2e-15
Identities = 48/133 (36%), Positives = 60/133 (45%), Gaps = 6/133 (4%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST-SHP 69
C C G+ G C+ H DPC C G C G+ CRC GF G C+ S
Sbjct: 1080 CACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPD-GRFECRCPPGFGGPRCRLPVPSKE 1137
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFS 128
C ++ CL+G C S C+C G G+ CQ T C ++PC NG TC
Sbjct: 1138 CSLNVTCLDGSPCEGGS-PAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSE 1196
Query: 129 CKCLTGFTGQKCE 141
C C F+GQ CE
Sbjct: 1197 CICNARFSGQFCE 1209
Score = 67.4 bits (163), Expect = 1e-11
Identities = 39/107 (36%), Positives = 50/107 (46%), Gaps = 9/107 (8%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCV----AQAMLGKATCRCASGF 57
C T+ +G C+CP GF G C R P C TC+ + A C C G
Sbjct: 1108 CHTHPDGRFECRCPPGFGGPRC--RLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGL 1165
Query: 58 TGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ 104
G+ CQ T PC + PCLNGGTC + EC C F+G+ C+
Sbjct: 1166 AGQRCQVPTL-PC-EANPCLNGGTCR-AAGGVSECICNARFSGQFCE 1209
Score = 52.0 bits (123), Expect = 4e-07
Identities = 23/62 (37%), Positives = 30/62 (48%), Gaps = 1/62 (1%)
Query: 150 PGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
P C H G C +L ++ C C G+ G C++ PC +PC G C D FEC C
Sbjct: 1062 PSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARG-RCHTHPDGRFECRC 1120
Query: 210 LP 211
P
Sbjct: 1121 PP 1122
Score = 51.2 bits (121), Expect = 8e-07
Identities = 27/67 (40%), Positives = 35/67 (52%), Gaps = 3/67 (4%)
Query: 12 CKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C C EG G+ CQ PCE N C NGGTC A G + C C + F+G+ C+ + P
Sbjct: 1159 CSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAG--GVSECICNARFSGQFCEVAKGLPL 1216
Query: 71 FVSRPCL 77
+ P L
Sbjct: 1217 PLPFPLL 1223
Score = 50.8 bits (120), Expect = 1e-06
Identities = 22/55 (40%), Positives = 29/55 (52%), Gaps = 1/55 (1%)
Query: 75 PCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSC 129
PC NGGTC +++ + + CTC FTG C C PC +TC V + F C
Sbjct: 815 PCFNGGTC-LVTWNDFHCTCPANFTGPTCAQQLWCPGQPCLPPATCEEVPDGFVC 868
Score = 47.8 bits (112), Expect = 8e-06
Identities = 24/67 (35%), Positives = 27/67 (40%), Gaps = 4/67 (5%)
Query: 103 CQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGH-CQHGGTCLN 161
C D C PC NG TC N F C C FTG C + PG C TC
Sbjct: 805 CVSEDMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTC---AQQLWCPGQPCLPPATCEE 861
Query: 162 LPGSYQC 168
+P + C
Sbjct: 862 VPDGFVC 868
Score = 42.0 bits (97), Expect = 5e-04
Identities = 24/76 (31%), Positives = 31/76 (40%), Gaps = 6/76 (7%)
Query: 23 CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC 82
C D C + C NGGTC+ C C + FTG C P +PCL TC
Sbjct: 805 CVSEDMCSPDPCFNGGTCL--VTWNDFHCTCPANFTGPTCAQQLWCP---GQPCLPPATC 859
Query: 83 HMLSRDTYECTCQVGF 98
+ D + C + F
Sbjct: 860 EEVP-DGFVCVAEATF 874
Score = 40.8 bits (94), Expect = 0.001
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 1/53 (1%)
Query: 150 PGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGD 202
P C +GGTCL + C C FTG C + + C PC+ TC + D
Sbjct: 813 PDPCFNGGTCLVTWNDFHCTCPANFTGPTC-AQQLWCPGQPCLPPATCEEVPD 864
Score = 33.5 bits (75), Expect = 0.16
Identities = 13/24 (54%), Positives = 15/24 (62%), Gaps = 1/24 (4%)
Query: 186 CAPSPCVNGGTCRQTGDFTFECNC 209
C+P PC NGGTC T + F C C
Sbjct: 811 CSPDPCFNGGTCLVTWN-DFHCTC 833
Score = 32.7 bits (73), Expect = 0.28
Identities = 11/42 (26%), Positives = 18/42 (42%)
Query: 103 CQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDV 144
C+ + C PC +G +C + F C C G C ++
Sbjct: 603 CERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 30.4 bits (67), Expect = 1.4
Identities = 11/30 (36%), Positives = 17/30 (56%)
Query: 150 PGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
P C HGG+C++L ++C C + G C
Sbjct: 611 PLPCVHGGSCVDLWTHFRCDCARPHRGPTC 640
Score = 28.5 bits (62), Expect = 5.3
Identities = 19/57 (33%), Positives = 25/57 (43%), Gaps = 7/57 (12%)
Query: 10 GYCKCPEGFLGEY----CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC 62
G+ PE LGE C+ R+ C C +GG+CV + C CA G C
Sbjct: 587 GHLLLPED-LGENVLLGCERREQCRPLPCVHGGSCV--DLWTHFRCDCARPHRGPTC 640
Score = 28.1 bits (61), Expect = 6.9
Identities = 11/24 (45%), Positives = 14/24 (58%), Gaps = 1/24 (4%)
Query: 186 CAPSPCVNGGTCRQTGDFTFECNC 209
C P PCV+GG+C F C+C
Sbjct: 609 CRPLPCVHGGSCVDLWTH-FRCDC 631
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 140 bits (352), Expect = 1e-33
Identities = 74/207 (35%), Positives = 99/207 (47%), Gaps = 17/207 (8%)
Query: 12 CKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCF 71
C+C G+ G C ++C C+ C C G+ GE C
Sbjct: 43 CRCQPGWQGPLC--------DQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVR--AC 92
Query: 72 VSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDA-CLSH--PCANGSTCTTV---AN 125
S PC N GTC L YEC+C G++GK+CQ D C+ + PC +G TC A+
Sbjct: 93 SSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRAS 152
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
SC C GF+G CE N C P C++ G C ++ G ++C+C GF + C
Sbjct: 153 HASCLCPPGFSGNFCEIVANSCT-PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTN 211
Query: 186 CAPSPCVNGGTCRQTGDFTFECNCLPE 212
CA SPC NGGTC Q ++EC C PE
Sbjct: 212 CASSPCQNGGTCLQHTQVSYECLCKPE 238
Score = 120 bits (301), Expect = 1e-27
Identities = 69/177 (38%), Positives = 91/177 (51%), Gaps = 11/177 (6%)
Query: 10 GYCKCPEGFLGEYCQHRD--PCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
G C C +G+ GE C RD C C N GTCV+ G C CA G++G+DCQ
Sbjct: 72 GQCICTDGWDGELCD-RDVRACSSAPCANNGTCVSLDD-GLYECSCAPGYSGKDCQKKDG 129
Query: 68 HPCFVS-RPCLNGGTC-HMLSRDTY-ECTCQVGFTGKECQWT-DACLSHPCANGSTCTTV 123
PC ++ PC +GGTC R ++ C C GF+G C+ ++C +PC N CT +
Sbjct: 130 -PCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDI 188
Query: 124 ANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCL-NLPGSYQCQCLQGFTGQYC 179
F C+C GF + C V C CQ+GGTCL + SY+C C FTG C
Sbjct: 189 GGDFRCRCPAGFIDKTCSRPVTNC-ASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
Score = 92.8 bits (229), Expect = 2e-19
Identities = 54/145 (37%), Positives = 70/145 (48%), Gaps = 9/145 (6%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRD-PCEKN--RCQNGGTCV-AQAMLGKATCRCASGF 57
CV+ +G C C G+ G+ CQ +D PC N CQ+GGTCV + A+C C GF
Sbjct: 103 CVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGF 162
Query: 58 TGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCAN 116
+G C+ ++ C PC N G C + D + C C GF K C + C S PC N
Sbjct: 163 SGNFCEI-VANSC-TPNPCENDGVCTDIGGD-FRCRCPAGFIDKTCSRPVTNCASSPCQN 219
Query: 117 GSTCTTVAN-QFSCKCLTGFTGQKC 140
G TC + C C FTG C
Sbjct: 220 GGTCLQHTQVSYECLCKPEFTGLTC 244
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 130 bits (328), Expect = 8e-31
Identities = 76/239 (31%), Positives = 112/239 (46%), Gaps = 22/239 (9%)
Query: 4 TYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQA------------MLGKAT 50
T+ G + KC GF G C+ D C + C+NG TC+ Q ++ +
Sbjct: 659 THLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFS 718
Query: 51 CRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDAC 109
C C G+ G C+ C ++ C + TC L +Y+C C + G C Q ++ C
Sbjct: 719 CLCNPGYVGIRCEQDIDD-CILNA-CEHNSTCKDLHL-SYQCVCLSDWEGNFCEQESNEC 775
Query: 110 LSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC--LNLPGSYQ 167
+PC N STCT + + C+C +G+TGQ C ++NECD C +GG C +PG +
Sbjct: 776 KMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECD-SDPCMNGGLCHESTIPGQFV 834
Query: 168 CQCLQGFTGQYCDSLYVPC--APSPCVNGGTCRQTGDFTFECNCLPETVRRGTELWERD 224
C C +TGQ+C Y C +PC N TC D C C E + E+ +D
Sbjct: 835 CLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKD 893
Score = 128 bits (322), Expect = 4e-30
Identities = 71/210 (33%), Positives = 109/210 (51%), Gaps = 15/210 (7%)
Query: 10 GY-CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
GY C C G+ G C+ + D C C + G C+ + TC C SGF G C+ + +
Sbjct: 987 GYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDG--INHYTCDCKSGFFGTHCE-TNA 1043
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQ 126
+ C +S PCL+G +++ Y C+C T +C+ + C S PC N C A+
Sbjct: 1044 NDC-LSNPCLHGRCTELINE--YPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHG 1100
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGH----CQHGGTCLNLPG-SYQCQCLQGFTGQYCDS 181
F+C C G+TG CE ++ C P C +GG C++ PG ++ C+CL GF+GQ+C+
Sbjct: 1101 FTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEI 1160
Query: 182 LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C+ SPC++G C + + C C P
Sbjct: 1161 NINECSSSPCLHGADCEDHIN-GYVCKCQP 1189
Score = 128 bits (321), Expect = 5e-30
Identities = 75/208 (36%), Positives = 104/208 (50%), Gaps = 14/208 (6%)
Query: 12 CKCPEGFLGEYC-QHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C C + G +C Q + C+ N C+N TC + C C SG+TG++C +
Sbjct: 757 CVCLSDWEGNFCEQESNECKMNPCKNNSTCTD--LYKSYRCECTSGWTGQNCSEEINE-- 812
Query: 71 FVSRPCLNGGTCHMLS-RDTYECTCQVGFTGKEC-QWTDAC--LSHPCANGSTCTTV--A 124
S PC+NGG CH + + C C +TG+ C Q + C L +PC N STC + A
Sbjct: 813 CDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDA 872
Query: 125 NQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYV 184
NQ C C F G+ CE DV +C CQ G C ++ +++C C GF+G C+
Sbjct: 873 NQH-CICREEFEGKNCEIDVKDCLFLS-CQDYGDCEDMVNNFRCICRPGFSGSLCEIEIN 930
Query: 185 PCAPSPCVNGGTCRQTGDFTFECNCLPE 212
C+ PC N GTC + F CNC PE
Sbjct: 931 ECSSEPCKNNGTCVDLTN-RFFCNCEPE 957
Score = 124 bits (312), Expect = 5e-29
Identities = 75/243 (30%), Positives = 103/243 (42%), Gaps = 48/243 (19%)
Query: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C C GF G C+ + C C+N GTCV + + C C + G C+ + C
Sbjct: 914 CICRPGFSGSLCEIEINECSSEPCKNNGTCVD--LTNRFFCNCEPEYHGPFCELDVNK-C 970
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSC 129
+S PCL+ C + D Y C C G+TG C+ D CLS PC + C N ++C
Sbjct: 971 KIS-PCLDEENC-VYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTC 1028
Query: 130 KCLTGFTGQKCETDVNEC---------------DIPGHCQHGGT----------CLNLP- 163
C +GF G CET+ N+C + P C GT C ++P
Sbjct: 1029 DCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPC 1088
Query: 164 ----------GSYQCQCLQGFTGQYCDSLYVPCAPSP-----CVNGGTCRQTGDFTFECN 208
+ C C +G+TG YC+ CA C+NGG C TF+C
Sbjct: 1089 MNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCR 1148
Query: 209 CLP 211
CLP
Sbjct: 1149 CLP 1151
Score = 108 bits (271), Expect = 3e-24
Identities = 64/208 (30%), Positives = 96/208 (46%), Gaps = 24/208 (11%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C C GF G +C+ + + C N C +G ++ + C C + T C+ +
Sbjct: 1028 CDCKSGFFGTHCETNANDCLSNPCLHGR---CTELINEYPCSCDADGTSTQCKIKIND-- 1082
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHP------CANGSTCTT-V 123
S PC+N G C S + C C G+TG C+ + + P C NG C
Sbjct: 1083 CTSIPCMNEGFCQK-SAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGP 1141
Query: 124 ANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLY 183
+ F C+CL GF+GQ CE ++NEC C HG C + Y C+C G++G +C++
Sbjct: 1142 GHTFDCRCLPGFSGQFCEININECS-SSPCLHGADCEDHINGYVCKCQPGWSGHHCEN-E 1199
Query: 184 VPCAPSPCVN--------GGTCRQTGDF 203
+ C P+ CV+ G TC T F
Sbjct: 1200 LECIPNSCVHELCMENEPGSTCLCTPGF 1227
Score = 97.8 bits (242), Expect = 7e-21
Identities = 58/216 (26%), Positives = 93/216 (43%), Gaps = 17/216 (7%)
Query: 12 CKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKA---TCRCASGFTGEDCQ----Y 64
C C F G+YCQ D C C+N G+C+ + C C FTG++C
Sbjct: 200 CHCQPPFSGKYCQELDACSFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQ 259
Query: 65 STSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTV 123
H CF G C ++ +++ C C F+G C+ + C+S C
Sbjct: 260 CQPHVCF-------HGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNS 312
Query: 124 ANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLY 183
++ ++ +C G + Q ETDV+E + CQ+G C+ + C C FT C S+
Sbjct: 313 SSAYTYECPKGSSSQNGETDVSEFSLV-PCQNGTDCIKISNDVMCICSPIFTDLLCKSIQ 371
Query: 184 VPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTE 219
C P N TC++ + + C+C+ + E
Sbjct: 372 TSCESFPLRNNATCKKC-EKDYPCSCISGFTEKNCE 406
Score = 92.4 bits (228), Expect = 3e-19
Identities = 55/206 (26%), Positives = 94/206 (45%), Gaps = 21/206 (10%)
Query: 22 YCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGT 81
Y ++ ++N CQ+ C + + + C C+ + G C + + C + G
Sbjct: 563 YLENTTDDQENECQHEAVCKDE--INRPRCSCSLSYIGRLCVVNVDY-CLGNHSISVHGL 619
Query: 82 CHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKC 140
C LS + C+ + C+ T+ C S C NG+T T + F KC+ GF G +C
Sbjct: 620 CLALSHNC-NCSGLQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQC 678
Query: 141 ETDVNECDIPGHCQHGGTCLNLPGSYQCQCL--------------QGFTGQYCDSLYVPC 186
E D++EC C++G TC++ PG+Y CQC+ G+ G C+ C
Sbjct: 679 EIDIDEC-ASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDC 737
Query: 187 APSPCVNGGTCRQTGDFTFECNCLPE 212
+ C + TC+ +++C CL +
Sbjct: 738 ILNACEHNSTCKDL-HLSYQCVCLSD 762
Score = 81.3 bits (199), Expect = 7e-16
Identities = 49/153 (32%), Positives = 65/153 (42%), Gaps = 13/153 (8%)
Query: 62 CQYSTSHPCFVSRPCLNGGTCHMLS-RDTYECTCQVGFTGKECQWTDACLSHPCANGSTC 120
CQ S S S C G C + TY C CQ F+GK CQ DAC PC N +C
Sbjct: 174 CQESLS-----SEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDACSFKPCKNNGSC 228
Query: 121 TTVANQ-----FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFT 175
+ C C FTG+ C + +C P C HG S+ C+C + F+
Sbjct: 229 INKRENWDEQAYECVCHPPFTGKNCSEIIGQCQ-PHVCFHGNCSNITSNSFICECDEQFS 287
Query: 176 GQYCDSLYVPCAPSPCVNGGTC-RQTGDFTFEC 207
G +C+ PC G C + +T+EC
Sbjct: 288 GPFCEVSAKPCVSLLFWKRGICPNSSSAYTYEC 320
Score = 80.9 bits (198), Expect = 9e-16
Identities = 50/181 (27%), Positives = 77/181 (42%), Gaps = 8/181 (4%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGE 60
C + + C+C E F G +C+ PC G C + T C G + +
Sbjct: 270 CSNITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS--SAYTYECPKGSSSQ 327
Query: 61 DCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTD-ACLSHPCANGST 119
+ + S V PC NG C +S D C C FT C+ +C S P N +T
Sbjct: 328 NGETDVSEFSLV--PCQNGTDCIKISNDVM-CICSPIFTDLLCKSIQTSCESFPLRNNAT 384
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPG-HCQHGGTCLNLPGSYQCQCLQGFTGQY 178
C + C C++GFT + CE ++ C + +C + C N+ G ++ C+ G T
Sbjct: 385 CKKCEKDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNP 444
Query: 179 C 179
C
Sbjct: 445 C 445
Score = 69.7 bits (169), Expect = 2e-12
Identities = 33/85 (38%), Positives = 38/85 (44%), Gaps = 4/85 (4%)
Query: 109 CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDI----PGHCQHGGTCLNLPG 164
C C NG TC C C TG+ G C V+ CD P HC G TC++LP
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673
Query: 165 SYQCQCLQGFTGQYCDSLYVPCAPS 189
Y C C G TG YC+ PS
Sbjct: 2674 GYTCFCPLGTTGIYCEQALSISDPS 2698
Score = 56.2 bits (134), Expect = 2e-08
Identities = 29/81 (35%), Positives = 41/81 (50%), Gaps = 4/81 (4%)
Query: 102 ECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCL- 160
+C T AC + C NG CT FSC+CL + G C V+ C + C H C+
Sbjct: 2873 DCDGT-ACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVS-C-LNNLCLHQSLCIP 2929
Query: 161 NLPGSYQCQCLQGFTGQYCDS 181
+ SY C C G+ G+YC++
Sbjct: 2930 DQSFSYSCLCTLGWVGRYCEN 2950
Score = 49.7 bits (117), Expect = 2e-06
Identities = 28/83 (33%), Positives = 35/83 (42%), Gaps = 6/83 (7%)
Query: 25 HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRP---CLNGGT 81
H PC +C NGGTC+ C C +G+ G C + S P C G T
Sbjct: 2610 HASPCSLMKCGNGGTCIESGT--SVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGAT 2667
Query: 82 CHMLSRDTYECTCQVGFTGKECQ 104
C L Y C C +G TG C+
Sbjct: 2668 CISLPHG-YTCFCPLGTTGIYCE 2689
Score = 48.9 bits (115), Expect = 4e-06
Identities = 26/84 (30%), Positives = 40/84 (47%), Gaps = 11/84 (13%)
Query: 59 GEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGS 118
G C Y+T C NGG C ++ T+ C C + G C + +CL++ C + S
Sbjct: 2876 GTACGYNT---------CRNGGEC-TVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQS 2925
Query: 119 TCTTVAN-QFSCKCLTGFTGQKCE 141
C + +SC C G+ G+ CE
Sbjct: 2926 LCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 47.4 bits (111), Expect = 1e-05
Identities = 23/76 (30%), Positives = 34/76 (44%), Gaps = 5/76 (6%)
Query: 29 CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRD 88
C N C+NGG C +CRC + G C S S ++ CL+ C
Sbjct: 2879 CGYNTCRNGGECTVNGT--TFSCRCLPDWAGNTCNQSVS---CLNNLCLHQSLCIPDQSF 2933
Query: 89 TYECTCQVGFTGKECQ 104
+Y C C +G+ G+ C+
Sbjct: 2934 SYSCLCTLGWVGRYCE 2949
Score = 47.0 bits (110), Expect = 1e-05
Identities = 24/71 (33%), Positives = 36/71 (50%), Gaps = 3/71 (4%)
Query: 76 CLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVA-NQFSCKCLTG 134
C N GTC + + C C ++GK CQ+ +C ++PC NG+TC + C C G
Sbjct: 2344 CRNNGTC-ISDNENLFCECPRLYSGKLCQFA-SCENNPCGNGATCVPKSGTDIVCLCPYG 2401
Query: 135 FTGQKCETDVN 145
+G C +N
Sbjct: 2402 RSGPLCTDAIN 2412
Score = 46.6 bits (109), Expect = 2e-05
Identities = 26/80 (32%), Positives = 38/80 (47%), Gaps = 8/80 (10%)
Query: 29 CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRD 88
C + C+N GTC++ C C ++G+ CQ+++ + PC NG TC S
Sbjct: 2339 CAHHLCRNNGTCISDNE--NLFCECPRLYSGKLCQFASCE----NNPCGNGATCVPKSGT 2392
Query: 89 TYECTCQVGFTGKECQWTDA 108
C C G +G C TDA
Sbjct: 2393 DIVCLCPYGRSGPLC--TDA 2410
Score = 42.7 bits (99), Expect = 3e-04
Identities = 29/130 (22%), Positives = 50/130 (38%), Gaps = 21/130 (16%)
Query: 1 MCVTYHNGTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTG 59
+CV T C+C GF G++C+ + + C + C +G C + + C+C G++G
Sbjct: 1136 ICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADC--EDHINGYVCKCQPGWSG 1193
Query: 60 EDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGST 119
C+ C+ H L C G C T ++ C+ G
Sbjct: 1194 HHCENELE--------CIPNSCVHEL--------CMENEPGSTCLCTPGFMT--CSIGLL 1235
Query: 120 CTTVANQFSC 129
C + +C
Sbjct: 1236 CGDEIRRITC 1245
Score = 42.7 bits (99), Expect = 3e-04
Identities = 20/71 (28%), Positives = 35/71 (49%), Gaps = 6/71 (8%)
Query: 143 DVNECDIP--GH--CQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCR 198
++ C +P H C++ GTC++ + C+C + ++G+ C + C +PC NG TC
Sbjct: 2330 NIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGATCV 2387
Query: 199 QTGDFTFECNC 209
C C
Sbjct: 2388 PKSGTDIVCLC 2398
Score = 42.0 bits (97), Expect = 5e-04
Identities = 20/52 (38%), Positives = 27/52 (51%), Gaps = 2/52 (3%)
Query: 11 YCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC 62
+C+CP + G+ CQ CE N C NG TCV ++ C C G +G C
Sbjct: 2358 FCECPRLYSGKLCQFAS-CENNPCGNGATCVPKSGT-DIVCLCPYGRSGPLC 2407
Score = 41.2 bits (95), Expect = 8e-04
Identities = 24/82 (29%), Positives = 39/82 (47%), Gaps = 6/82 (7%)
Query: 132 LTGFTGQKCETDVNECDIPG----HCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCA 187
LT F G K ++V +CD C++GG C ++ C+CL + G C+ V C
Sbjct: 2860 LTEF-GAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQS-VSCL 2917
Query: 188 PSPCVNGGTCRQTGDFTFECNC 209
+ C++ C F++ C C
Sbjct: 2918 NNLCLHQSLCIPDQSFSYSCLC 2939
Score = 38.9 bits (89), Expect = 0.004
Identities = 19/48 (39%), Positives = 28/48 (58%), Gaps = 5/48 (10%)
Query: 76 CLNGGTCHMLSRDT----YECTCQVGFTGKECQWTDACLSHPCANGST 119
C NGGTCH + + ++C C + FTG+ C+ DA L P NG++
Sbjct: 2108 CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE-KDAGLFFPSFNGNS 2154
Score = 38.5 bits (88), Expect = 0.005
Identities = 21/72 (29%), Positives = 32/72 (44%), Gaps = 4/72 (5%)
Query: 109 CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGS-YQ 167
C H C N TC + C+C ++G+ C+ C+ C +G TC+ G+
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCE-NNPCGNGATCVPKSGTDIV 2395
Query: 168 CQCLQGFTGQYC 179
C C G +G C
Sbjct: 2396 CLCPYGRSGPLC 2407
Score = 36.2 bits (82), Expect = 0.025
Identities = 24/74 (32%), Positives = 32/74 (43%), Gaps = 16/74 (21%)
Query: 11 YCKCPEGFLGEYC---------QHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGED 61
YC C G+ G +C +H P + C G TC+ ++ TC C G TG
Sbjct: 2633 YCNCTTGWKGSFCTETVSTCDPEHDPP---HHCSRGATCI--SLPHGYTCFCPLGTTGIY 2687
Query: 62 CQ--YSTSHPCFVS 73
C+ S S P F S
Sbjct: 2688 CEQALSISDPSFRS 2701
Score = 35.0 bits (79), Expect = 0.056
Identities = 17/64 (26%), Positives = 25/64 (39%), Gaps = 1/64 (1%)
Query: 4 TYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ 63
T + T C+C + G C C N C + C+ +C C G+ G C+
Sbjct: 2891 TVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSF-SYSCLCTLGWVGRYCE 2949
Query: 64 YSTS 67
TS
Sbjct: 2950 NKTS 2953
Score = 32.0 bits (71), Expect = 0.48
Identities = 15/34 (44%), Positives = 17/34 (50%), Gaps = 3/34 (8%)
Query: 179 CDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPE 212
CD C + C NGG C G TF C CLP+
Sbjct: 2874 CDG--TACGYNTCRNGGECTVNGT-TFSCRCLPD 2904
Score = 31.6 bits (70), Expect = 0.62
Identities = 18/58 (31%), Positives = 21/58 (36%), Gaps = 14/58 (24%)
Query: 100 GKECQWTDA---------CLSHPCANGSTCTTV-----ANQFSCKCLTGFTGQKCETD 143
G + WT C C NG TC + F C C FTG+ CE D
Sbjct: 2085 GVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKD 2142
Score = 30.8 bits (68), Expect = 1.1
Identities = 14/38 (36%), Positives = 20/38 (52%), Gaps = 3/38 (7%)
Query: 29 CEKNRCQNGGTCVA---QAMLGKATCRCASGFTGEDCQ 63
C+++ C NGGTC A + + C C FTG C+
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140
Score = 30.8 bits (68), Expect = 1.1
Identities = 12/25 (48%), Positives = 16/25 (64%), Gaps = 1/25 (4%)
Query: 185 PCAPSPCVNGGTCRQTGDFTFECNC 209
PC+ C NGGTC ++G + CNC
Sbjct: 2613 PCSLMKCGNGGTCIESGTSVY-CNC 2636
Score = 30.4 bits (67), Expect = 1.4
Identities = 16/46 (34%), Positives = 23/46 (50%), Gaps = 13/46 (28%)
Query: 140 CETDVNECDIPGHCQHGGTCLNL-----PGSYQCQCLQGFTGQYCD 180
C+ DV C +GGTC + S+QC C FTG++C+
Sbjct: 2103 CQQDV--------CHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCE 2140
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 130 bits (327), Expect = 1e-30
Identities = 64/176 (36%), Positives = 91/176 (51%), Gaps = 9/176 (5%)
Query: 27 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 86
+PC N C+N GTC + + C C GF G+DC H C +S PC +GGTCH+
Sbjct: 920 NPCLSNPCKNDGTCNSDPV-DFYRCTCPYGFKGQDCDVPI-HAC-ISNPCKHGGTCHLKE 976
Query: 87 --RDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETD 143
D + C C GF G+ C+ D C + C N STC N ++C C +TG+ CE
Sbjct: 977 GEEDGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEK 1036
Query: 144 VNEC--DIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTC 197
++ C D+ CQH C+ P ++C C G+ G++CD + C + C NG C
Sbjct: 1037 LDFCAQDL-NPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHC 1091
Score = 110 bits (276), Expect = 8e-25
Identities = 65/212 (30%), Positives = 94/212 (44%), Gaps = 17/212 (8%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTC-VAQAMLGKATCRCASGFTGEDCQYSTSHP 69
C CP GF G+ C C N C++GGTC + + C CA GF GE+C+ +
Sbjct: 943 CTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICADGFEGENCEVNVDD- 1001
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLS--HPCANGSTCTTVANQ 126
C N TC + + Y C C +TG+ C + D C +PC + S C
Sbjct: 1002 -CEDNDCENNSTC-VDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCILTPKG 1059
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD------ 180
F C C G+ G+ C+ D ++C C++G C + Y C C +G++G +C+
Sbjct: 1060 FKCDCTPGYVGEHCDIDFDDCQ-DNKCKNGAHCTDAVNGYTCICPEGYSGLFCEFSPPMV 1118
Query: 181 -SLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
PC C NG C + C CLP
Sbjct: 1119 LPRTSPCDNFDCQNGAQCIVRINEPI-CQCLP 1149
Score = 110 bits (275), Expect = 1e-24
Identities = 60/181 (33%), Positives = 87/181 (48%), Gaps = 13/181 (7%)
Query: 11 YCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
+C C +GF GE C+ + D CE N C+N TCV + TC C +TGE C+
Sbjct: 983 WCICADGFEGENCEVNVDDCEDNDCENNSTCVDG--INNYTCLCPPEYTGELCEEKLDFC 1040
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFS 128
PC + C +L+ ++C C G+ G+ C D C + C NG+ CT N ++
Sbjct: 1041 AQDLNPCQHDSKC-ILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYT 1099
Query: 129 CKCLTGFTGQKCETD-------VNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDS 181
C C G++G CE + CD CQ+G C+ CQCL G+ G+ C+
Sbjct: 1100 CICPEGYSGLFCEFSPPMVLPRTSPCD-NFDCQNGAQCIVRINEPICQCLPGYQGEKCEK 1158
Query: 182 L 182
L
Sbjct: 1159 L 1159
Score = 70.9 bits (172), Expect = 9e-13
Identities = 38/106 (35%), Positives = 52/106 (49%), Gaps = 6/106 (5%)
Query: 80 GTCHMLSRDTYECTCQVGFTGKEC--QWTDACLSHPCANGSTCTTVANQFSCKCLTGFTG 137
GTC S+ + C CQ G+ G C + D CL + C +G+ A +SCKCL G G
Sbjct: 1344 GTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSCKCLEGHGG 1403
Query: 138 QKCETD---VNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
C+ + N C C+HG L+ G C+C G+TG CD
Sbjct: 1404 VLCDEEEDLFNPCQAI-KCKHGKCRLSGLGQPYCECSSGYTGDSCD 1448
Score = 67.8 bits (164), Expect = 8e-12
Identities = 37/123 (30%), Positives = 60/123 (48%), Gaps = 8/123 (6%)
Query: 27 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 86
+PC K C +G TC + G TC C G+ G C T+ PC ++ C++G TC ++
Sbjct: 1334 EPCHKKVCAHG-TCQPSSQAG-FTCECQEGWMGPLCDQRTNDPCLGNK-CVHG-TCLPIN 1389
Query: 87 RDTYECTCQVGFTGKECQWTD----ACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCET 142
+Y C C G G C + C + C +G + Q C+C +G+TG C+
Sbjct: 1390 AFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYTGDSCDR 1449
Query: 143 DVN 145
+++
Sbjct: 1450 EIS 1452
Score = 62.4 bits (150), Expect = 3e-10
Identities = 36/107 (33%), Positives = 52/107 (48%), Gaps = 6/107 (5%)
Query: 107 DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPG-S 165
+ C CA+G+ + F+C+C G+ G C+ N+ + C H GTCL + S
Sbjct: 1334 EPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVH-GTCLPINAFS 1392
Query: 166 YQCQCLQGFTGQYCD---SLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
Y C+CL+G G CD L+ PC C + G CR +G C C
Sbjct: 1393 YSCKCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKCRLSGLGQPYCEC 1438
Score = 53.9 bits (128), Expect = 1e-07
Identities = 36/140 (25%), Positives = 52/140 (37%), Gaps = 15/140 (10%)
Query: 12 CKCPEGFLGEYCQHR--DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS-- 67
C+C EG++G C R DPC N+C +G A +C+C G G C
Sbjct: 1356 CECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAF--SYSCKCLEGHGGVLCDEEEDLF 1413
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCAN-------GSTC 120
+PC + G C + C C G+TG C +C + + C
Sbjct: 1414 NPCQAIK--CKHGKCRLSGLGQPYCECSSGYTGDSCDREISCRGERIRDYYQKQQGYAAC 1471
Query: 121 TTVANQFSCKCLTGFTGQKC 140
T +C G G +C
Sbjct: 1472 QTTKKVSRLECRGGCAGGQC 1491
Score = 43.9 bits (102), Expect = 1e-04
Identities = 23/78 (29%), Positives = 37/78 (47%), Gaps = 5/78 (6%)
Query: 153 CQHGGTCLNLPGSYQCQCLQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
C HG + + C+C +G+ G CD PC + CV+G TC F++ C CL
Sbjct: 1341 CAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHG-TCLPINAFSYSCKCLE 1399
Query: 212 ETVRRGTELWERDREVWN 229
G L + + +++N
Sbjct: 1400 ---GHGGVLCDEEEDLFN 1414
Score = 29.3 bits (64), Expect = 3.1
Identities = 10/25 (40%), Positives = 12/25 (48%)
Query: 185 PCAPSPCVNGGTCRQTGDFTFECNC 209
PC +PC N GTC + C C
Sbjct: 921 PCLSNPCKNDGTCNSDPVDFYRCTC 945
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 129 bits (324), Expect = 2e-30
Identities = 71/211 (33%), Positives = 99/211 (46%), Gaps = 16/211 (7%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQ-AMLGKATCRCASGFTGEDCQYSTSHP 69
C CP G+ G C+ D C C+NGGTC AQ TC C +GF G C +T
Sbjct: 950 CACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCPTGFEGPTCGVNTDD- 1008
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLS--HPCANGSTCTTVANQ 126
V C NGG C + Y C C + + GK C Q D C +PC + + C +
Sbjct: 1009 -CVDHACANGGVC-VDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGTPDG 1066
Query: 127 FSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD------ 180
C+C+ G+ G C + ++C CQ+G C++ SY C C +G++GQ C+
Sbjct: 1067 PRCECMPGYAGDNCSENQDDCR-DHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEIPPHLP 1125
Query: 181 SLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
+ PC + C NG C G+ C CLP
Sbjct: 1126 APKSPCEGTECQNGANCVDQGNRPV-CQCLP 1155
Score = 123 bits (309), Expect = 1e-28
Identities = 65/187 (34%), Positives = 86/187 (45%), Gaps = 8/187 (4%)
Query: 27 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 86
D C + CQN GTC L C C SG+ G DC+ S S PC NGGTCH
Sbjct: 927 DLCLSSPCQNQGTCHNDP-LEVYRCACPSGYKGRDCEVSLDSCS--SGPCENGGTCHAQE 983
Query: 87 RDT--YECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETD 143
+ + C+C GF G C TD C+ H CANG C ++C+C + G+ CE
Sbjct: 984 GEDAPFTCSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQL 1043
Query: 144 VNECDIP-GHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGD 202
V+ C CQH C+ P +C+C+ G+ G C C C NG C +
Sbjct: 1044 VDLCSPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVN 1103
Query: 203 FTFECNC 209
++ C C
Sbjct: 1104 -SYSCLC 1109
Score = 108 bits (270), Expect = 4e-24
Identities = 62/185 (33%), Positives = 81/185 (43%), Gaps = 24/185 (12%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C CP GF G C + D C + C NGG CV +G TC+C + G+ C+
Sbjct: 991 CSCPTGFEGPTCGVNTDDCVDHACANGGVCVDG--VGNYTCQCPLQYEGKACEQLVDLCS 1048
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSC 129
PC + C + + D C C G+ G C D C H C NG+ C N +SC
Sbjct: 1049 PDLNPCQHEAQC-VGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
Query: 130 KCLTGFTGQKCETDVNECDIPGH------------CQHGGTCLNLPGSYQCQCLQGFTGQ 177
C G++GQ CE IP H CQ+G C++ CQCL GF G
Sbjct: 1108 LCAEGYSGQLCE-------IPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGP 1160
Query: 178 YCDSL 182
C+ L
Sbjct: 1161 ECEKL 1165
Score = 60.8 bits (146), Expect = 1e-09
Identities = 39/125 (31%), Positives = 54/125 (43%), Gaps = 9/125 (7%)
Query: 27 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 86
+PC K C +G C A G C C +G+ G C PC C++G C L
Sbjct: 1340 EPCRKLYCLHG-ICQPNATPGPM-CHCEAGWVGLHCDQPADGPCH-GHKCVHG-QCVPLD 1395
Query: 87 RDTYECTCQVGFTGKECQWTDA----CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCET 142
+Y C CQ G++G C A C C +G + C C GF+G+ CE
Sbjct: 1396 ALSYSCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCEQ 1455
Query: 143 DVNEC 147
+ +EC
Sbjct: 1456 E-SEC 1459
Score = 53.1 bits (126), Expect = 2e-07
Identities = 36/114 (31%), Positives = 51/114 (44%), Gaps = 15/114 (13%)
Query: 76 CLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDA-CLSHPCANGSTCTTVANQFSCKCLT 133
CL+G C + C C+ G+ G C Q D C H C +G A +SC+C
Sbjct: 1347 CLHG-ICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSYSCQCQD 1405
Query: 134 GFTGQKCETD---VNECD----IPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
G++G C C + GHCQ GT G++ C C GF+G+ C+
Sbjct: 1406 GYSGALCNQAGALAEPCRGLQCLHGHCQASGT----KGAH-CVCDPGFSGELCE 1454
Score = 50.8 bits (120), Expect = 1e-06
Identities = 35/140 (25%), Positives = 55/140 (39%), Gaps = 15/140 (10%)
Query: 12 CKCPEGFLGEYCQHR--DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYS--TS 67
C C G++G +C PC ++C +G A+ +C+C G++G C + +
Sbjct: 1362 CHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDAL--SYSCQCQDGYSGALCNQAGALA 1419
Query: 68 HPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCAN-------GSTC 120
PC CL+G C C C GF+G+ C+ C P + + C
Sbjct: 1420 EPCR-GLQCLHGH-CQASGTKGAHCVCDPGFSGELCEQESECRGDPVRDFHQVQRGYAIC 1477
Query: 121 TTVANQFSCKCLTGFTGQKC 140
T +C GQ C
Sbjct: 1478 QTTRPLSWVECRGSCPGQGC 1497
Score = 33.1 bits (74), Expect = 0.21
Identities = 18/59 (30%), Positives = 24/59 (40%), Gaps = 2/59 (3%)
Query: 152 HCQHGGTCLNLPGSYQCQCLQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNC 209
+C HG N C C G+ G +CD PC CV+ G C ++ C C
Sbjct: 1346 YCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVH-GQCVPLDALSYSCQC 1403
Score = 30.4 bits (67), Expect = 1.4
Identities = 26/109 (23%), Positives = 40/109 (36%), Gaps = 19/109 (17%)
Query: 11 YCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
+C C GF GE C+ C + ++ Q G A C+ + +C+ S
Sbjct: 1441 HCVCDPGFSGELCEQESECRGDPVRD----FHQVQRGYAICQTTRPLSWVECRGS----- 1491
Query: 71 FVSRPCLNGGTCHML----SRDTYECTCQVGFTGKECQWTDACLSHPCA 115
C G C L + T+EC+ F +E + C CA
Sbjct: 1492 -----CPGQGCCQGLRLKRRKFTFECSDGTSF-AEEVEKPTKCGCALCA 1534
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 128 bits (322), Expect = 4e-30
Identities = 71/215 (33%), Positives = 91/215 (42%), Gaps = 32/215 (14%)
Query: 10 GYCKCPEGFLGEYC------------------------QHRDPCEKNRCQNGGTCVAQAM 45
G C+C EG+ G C PC+ N C NGG+C
Sbjct: 235 GECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPR 294
Query: 46 LGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC--HMLSRDTYECTCQVGFTGKEC 103
C C GF G C+ S PC NGG C Y C C GF G C
Sbjct: 295 --SFECTCPRGFYGLRCE--VSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNC 350
Query: 104 Q-WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNL 162
+ D C PC NG C + + C+C GF G +CE D+++C C +GGTC+
Sbjct: 351 EKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDC-AGRACANGGTCVEG 409
Query: 163 PGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTC 197
G+++C C GF G+ C PCA PC +GG C
Sbjct: 410 GGAHRCSCALGFGGRDCRERADPCAARPCAHGGRC 444
Score = 108 bits (271), Expect = 3e-24
Identities = 61/172 (35%), Positives = 72/172 (41%), Gaps = 7/172 (4%)
Query: 12 CKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKA-TCRCASGFTGEDCQYSTSHP 69
C CP GF G C+ C C NGG CV A A C C GF G +C+
Sbjct: 298 CTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDR- 356
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFS 128
C + +PC NGG C L C C+ GF G C+ D C CANG TC
Sbjct: 357 CSL-QPCRNGGLCLDLGH-ALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHR 414
Query: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
C C GF G+ C + C C HGG C C C G+ G C+
Sbjct: 415 CSCALGFGGRDCRERADPC-AARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
Score = 102 bits (253), Expect = 4e-22
Identities = 52/137 (37%), Positives = 71/137 (51%), Gaps = 9/137 (6%)
Query: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKAT-CRCASGFTGEDCQYSTSHP 69
C CP GF G C+ R D C C+NGG C+ LG A CRC +GF G C++
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLD---LGHALRCRCRAGFAGPRCEHDLDD- 394
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFS 128
R C NGGTC + + C+C +GF G++C + D C + PCA+G C +
Sbjct: 395 -CAGRACANGGTC-VEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV 452
Query: 129 CKCLTGFTGQKCETDVN 145
C C G+ G +CE V+
Sbjct: 453 CACAPGYMGARCEFPVH 469
Score = 66.6 bits (161), Expect = 2e-11
Identities = 36/107 (33%), Positives = 48/107 (44%), Gaps = 24/107 (22%)
Query: 129 CKCLTGFTGQKCETDVNE---------------CDIPGH-------CQHGGTCLNLPGSY 166
C+CL G+TG C V+ C +PG C +GG+C P S+
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSF 296
Query: 167 QCQCLQGFTGQYCDSLYVPCAPSPCVNGGTC--RQTGDFTFECNCLP 211
+C C +GF G C+ V CA PC NGG C D + C+C P
Sbjct: 297 ECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
Score = 49.7 bits (117), Expect = 2e-06
Identities = 37/125 (29%), Positives = 51/125 (40%), Gaps = 32/125 (25%)
Query: 113 PCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHG-----GTCLNLPGSYQ 167
P A G+ CT + S G + C +EC+ P C+ G G C PG +
Sbjct: 180 PPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG--E 236
Query: 168 CQCLQGFTGQYCDSLYV-----------------------PCAPSPCVNGGTCRQTGDFT 204
C+CL+G+TG C PC +PC NGG+C +T +
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSET-PRS 295
Query: 205 FECNC 209
FEC C
Sbjct: 296 FECTC 300
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 128 bits (322), Expect = 4e-30
Identities = 71/215 (33%), Positives = 91/215 (42%), Gaps = 32/215 (14%)
Query: 10 GYCKCPEGFLGEYC------------------------QHRDPCEKNRCQNGGTCVAQAM 45
G C+C EG+ G C PC+ N C NGG+C
Sbjct: 235 GECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPR 294
Query: 46 LGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC--HMLSRDTYECTCQVGFTGKEC 103
C C GF G C+ S PC NGG C Y C C GF G C
Sbjct: 295 --SFECTCPRGFYGLRCE--VSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNC 350
Query: 104 Q-WTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNL 162
+ D C PC NG C + + C+C GF G +CE D+++C C +GGTC+
Sbjct: 351 EKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDC-AGRACANGGTCVEG 409
Query: 163 PGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTC 197
G+++C C GF G+ C PCA PC +GG C
Sbjct: 410 GGAHRCSCALGFGGRDCRERADPCAARPCAHGGRC 444
Score = 108 bits (271), Expect = 3e-24
Identities = 61/172 (35%), Positives = 72/172 (41%), Gaps = 7/172 (4%)
Query: 12 CKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKA-TCRCASGFTGEDCQYSTSHP 69
C CP GF G C+ C C NGG CV A A C C GF G +C+
Sbjct: 298 CTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDR- 356
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFS 128
C + +PC NGG C L C C+ GF G C+ D C CANG TC
Sbjct: 357 CSL-QPCRNGGLCLDLGH-ALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHR 414
Query: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
C C GF G+ C + C C HGG C C C G+ G C+
Sbjct: 415 CSCALGFGGRDCRERADPC-AARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
Score = 102 bits (253), Expect = 4e-22
Identities = 52/137 (37%), Positives = 71/137 (51%), Gaps = 9/137 (6%)
Query: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKAT-CRCASGFTGEDCQYSTSHP 69
C CP GF G C+ R D C C+NGG C+ LG A CRC +GF G C++
Sbjct: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLD---LGHALRCRCRAGFAGPRCEHDLDD- 394
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFS 128
R C NGGTC + + C+C +GF G++C + D C + PCA+G C +
Sbjct: 395 -CAGRACANGGTC-VEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV 452
Query: 129 CKCLTGFTGQKCETDVN 145
C C G+ G +CE V+
Sbjct: 453 CACAPGYMGARCEFPVH 469
Score = 66.6 bits (161), Expect = 2e-11
Identities = 36/107 (33%), Positives = 48/107 (44%), Gaps = 24/107 (22%)
Query: 129 CKCLTGFTGQKCETDVNE---------------CDIPGH-------CQHGGTCLNLPGSY 166
C+CL G+TG C V+ C +PG C +GG+C P S+
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSF 296
Query: 167 QCQCLQGFTGQYCDSLYVPCAPSPCVNGGTC--RQTGDFTFECNCLP 211
+C C +GF G C+ V CA PC NGG C D + C+C P
Sbjct: 297 ECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
Score = 49.7 bits (117), Expect = 2e-06
Identities = 37/125 (29%), Positives = 51/125 (40%), Gaps = 32/125 (25%)
Query: 113 PCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHG-----GTCLNLPGSYQ 167
P A G+ CT + S G + C +EC+ P C+ G G C PG +
Sbjct: 180 PPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG--E 236
Query: 168 CQCLQGFTGQYCDSLYV-----------------------PCAPSPCVNGGTCRQTGDFT 204
C+CL+G+TG C PC +PC NGG+C +T +
Sbjct: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSET-PRS 295
Query: 205 FECNC 209
FEC C
Sbjct: 296 FECTC 300
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 126 bits (316), Expect = 2e-29
Identities = 58/154 (37%), Positives = 87/154 (56%), Gaps = 5/154 (3%)
Query: 27 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 86
+ C N CQNGG C + G C+C++ + G C+ S + PC S+PCL GGTC ++
Sbjct: 4015 EDCASNPCQNGGVC-NPSPAGGYYCKCSALYIGTHCEISVN-PCS-SKPCLYGGTC-VVD 4070
Query: 87 RDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNE 146
+ C C+ +TG+ CQ + C PC NG TC + C+C +GF G++C++D++E
Sbjct: 4071 NGGFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDE 4130
Query: 147 CDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
C C HG C N GSY C C + G++C+
Sbjct: 4131 CS-GNPCLHGALCENTHGSYHCNCSHEYRGRHCE 4163
Score = 103 bits (258), Expect = 1e-22
Identities = 53/152 (34%), Positives = 74/152 (48%), Gaps = 5/152 (3%)
Query: 62 CQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTC 120
C + + C S PC NGG C+ Y C C + G C+ + + C S PC G TC
Sbjct: 4009 CFLTATEDC-ASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTC 4067
Query: 121 TTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
F C+C +TGQ+C+ D P C++GGTC + CQC GF G+ C
Sbjct: 4068 VVDNGGFVCQCRGLYTGQRCQLSPYCKDEP--CKNGGTCFDSLDGAVCQCDSGFRGERCQ 4125
Query: 181 SLYVPCAPSPCVNGGTCRQTGDFTFECNCLPE 212
S C+ +PC++G C T ++ CNC E
Sbjct: 4126 SDIDECSGNPCLHGALCENTHG-SYHCNCSHE 4156
Score = 97.4 bits (241), Expect = 9e-21
Identities = 51/136 (37%), Positives = 66/136 (48%), Gaps = 8/136 (5%)
Query: 8 GTGYCKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
G YCKC ++G +C+ +PC C GGTCV G C+C +TG+ CQ S
Sbjct: 4034 GGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDN--GGFVCQCRGLYTGQRCQLS- 4090
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVAN 125
P PC NGGTC S D C C GF G+ CQ D C +PC +G+ C
Sbjct: 4091 --PYCKDEPCKNGGTC-FDSLDGAVCQCDSGFRGERCQSDIDECSGNPCLHGALCENTHG 4147
Query: 126 QFSCKCLTGFTGQKCE 141
+ C C + G+ CE
Sbjct: 4148 SYHCNCSHEYRGRHCE 4163
Score = 69.7 bits (169), Expect = 2e-12
Identities = 37/98 (37%), Positives = 49/98 (50%), Gaps = 5/98 (5%)
Query: 7 NGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
NG C+C + G+ CQ C+ C+NGGTC L A C+C SGF GE CQ S
Sbjct: 4071 NGGFVCQCRGLYTGQRCQLSPYCKDEPCKNGGTCFDS--LDGAVCQCDSGFRGERCQ-SD 4127
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ 104
C PCL+G C + +Y C C + G+ C+
Sbjct: 4128 IDEC-SGNPCLHGALCEN-THGSYHCNCSHEYRGRHCE 4163
Score = 33.9 bits (76), Expect = 0.13
Identities = 21/62 (33%), Positives = 26/62 (41%), Gaps = 4/62 (6%)
Query: 6 HNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYS 65
H+ C C EG CE + C G CV+ K TC C SG G+ C S
Sbjct: 3774 HHRAAVCLCKEGRCPPV---HHGCEDDPCPEGSECVSDPWEEKHTCVCPSGRFGQ-CPGS 3829
Query: 66 TS 67
+S
Sbjct: 3830 SS 3831
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 125 bits (313), Expect = 4e-29
Identities = 70/209 (33%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 10 GYCKCPEGFLGEYCQH--RDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
G C+C G+ G +C+ R P C+ C C+ C SG+ G+ C
Sbjct: 44 GSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCI-----------CHSGWAGKFCD-KD 91
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDAC--LSHPCANGSTCTT- 122
H C PC NGG C Y C C GF G++C+ C PC NG C
Sbjct: 92 EHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDD 151
Query: 123 --VANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
A F+C+CL GF G +CE +V++C + C +G TCL+ + C C +GF G++C
Sbjct: 152 QGFALNFTCRCLVGFVGARCEVNVDDC-LMRPCANGATCLDGINRFSCLCPEGFAGRFCT 210
Query: 181 SLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
CA PC G CR F+C C
Sbjct: 211 INLDDCASRPCQRGARCRDR-VHDFDCLC 238
Score = 118 bits (296), Expect = 4e-27
Identities = 67/185 (36%), Positives = 91/185 (49%), Gaps = 10/185 (5%)
Query: 12 CKCPEGFLGEYCQHRDPC--EKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
C C G+ G++C + ++ CQNGG C+ G+ C C GF G DC+ P
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG-GEYHCVCLPGFHGRDCERKAG-P 134
Query: 70 CF-VSRPCLNGGTCH--MLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 125
C PC NGG C + C C VGF G C+ D CL PCANG+TC N
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD-SLYV 184
+FSC C GF G+ C ++++C CQ G C + + C C G+ G+ C+ L V
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDC-ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPV 253
Query: 185 PCAPS 189
P P+
Sbjct: 254 PDPPT 258
Score = 96.3 bits (238), Expect = 2e-20
Identities = 53/145 (36%), Positives = 72/145 (49%), Gaps = 8/145 (5%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEK--NRCQNGGTCV-AQAMLGKATCRCASGF 57
C+ G +C C GF G C+ + PCE+ + C+NGG C Q TCRC GF
Sbjct: 107 CMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGF 166
Query: 58 TGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCAN 116
G C+ + C + RPC NG TC + + + C C GF G+ C D C S PC
Sbjct: 167 VGARCEVNVD-DCLM-RPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQR 223
Query: 117 GSTCTTVANQFSCKCLTGFTGQKCE 141
G+ C + F C C +G+ G+ CE
Sbjct: 224 GARCRDRVHDFDCLCPSGYGGKTCE 248
Score = 65.9 bits (159), Expect = 3e-11
Identities = 45/119 (37%), Positives = 58/119 (48%), Gaps = 13/119 (10%)
Query: 94 CQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHC 153
C +G G+ + D C SH C C A SC+C G+ G CE V +PG C
Sbjct: 15 CILGAPGQPVR-ADDCSSH-CDLAHGCC--APDGSCRCDPGWEGLHCERCVR---MPG-C 66
Query: 154 QHGGTCLNLPGSYQCQCLQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
QHG TC +QC C G+ G++CD ++ SPC NGG C G + C CLP
Sbjct: 67 QHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 125 bits (313), Expect = 4e-29
Identities = 70/209 (33%), Positives = 95/209 (45%), Gaps = 23/209 (11%)
Query: 10 GYCKCPEGFLGEYCQH--RDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYST 66
G C+C G+ G +C+ R P C+ C C+ C SG+ G+ C
Sbjct: 44 GSCRCDPGWEGLHCERCVRMPGCQHGTCHQPWQCI-----------CHSGWAGKFCD-KD 91
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDAC--LSHPCANGSTCTT- 122
H C PC NGG C Y C C GF G++C+ C PC NG C
Sbjct: 92 EHICTTQSPCQNGGQCMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDD 151
Query: 123 --VANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
A F+C+CL GF G +CE +V++C + C +G TCL+ + C C +GF G++C
Sbjct: 152 QGFALNFTCRCLVGFVGARCEVNVDDC-LMRPCANGATCLDGINRFSCLCPEGFAGRFCT 210
Query: 181 SLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
CA PC G CR F+C C
Sbjct: 211 INLDDCASRPCQRGARCRDR-VHDFDCLC 238
Score = 118 bits (296), Expect = 4e-27
Identities = 67/185 (36%), Positives = 91/185 (49%), Gaps = 10/185 (5%)
Query: 12 CKCPEGFLGEYCQHRDPC--EKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHP 69
C C G+ G++C + ++ CQNGG C+ G+ C C GF G DC+ P
Sbjct: 77 CICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGG-GEYHCVCLPGFHGRDCERKAG-P 134
Query: 70 CF-VSRPCLNGGTCH--MLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 125
C PC NGG C + C C VGF G C+ D CL PCANG+TC N
Sbjct: 135 CEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVDDCLMRPCANGATCLDGIN 194
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD-SLYV 184
+FSC C GF G+ C ++++C CQ G C + + C C G+ G+ C+ L V
Sbjct: 195 RFSCLCPEGFAGRFCTINLDDC-ASRPCQRGARCRDRVHDFDCLCPSGYGGKTCELVLPV 253
Query: 185 PCAPS 189
P P+
Sbjct: 254 PDPPT 258
Score = 96.3 bits (238), Expect = 2e-20
Identities = 53/145 (36%), Positives = 72/145 (49%), Gaps = 8/145 (5%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHR-DPCEK--NRCQNGGTCV-AQAMLGKATCRCASGF 57
C+ G +C C GF G C+ + PCE+ + C+NGG C Q TCRC GF
Sbjct: 107 CMYDGGGEYHCVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGF 166
Query: 58 TGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCAN 116
G C+ + C + RPC NG TC + + + C C GF G+ C D C S PC
Sbjct: 167 VGARCEVNVD-DCLM-RPCANGATC-LDGINRFSCLCPEGFAGRFCTINLDDCASRPCQR 223
Query: 117 GSTCTTVANQFSCKCLTGFTGQKCE 141
G+ C + F C C +G+ G+ CE
Sbjct: 224 GARCRDRVHDFDCLCPSGYGGKTCE 248
Score = 65.9 bits (159), Expect = 3e-11
Identities = 45/119 (37%), Positives = 58/119 (48%), Gaps = 13/119 (10%)
Query: 94 CQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHC 153
C +G G+ + D C SH C C A SC+C G+ G CE V +PG C
Sbjct: 15 CILGAPGQPVR-ADDCSSH-CDLAHGCC--APDGSCRCDPGWEGLHCERCVR---MPG-C 66
Query: 154 QHGGTCLNLPGSYQCQCLQGFTGQYCDS-LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
QHG TC +QC C G+ G++CD ++ SPC NGG C G + C CLP
Sbjct: 67 QHG-TCHQ---PWQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCMYDGGGEYHCVCLP 121
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 125 bits (313), Expect = 4e-29
Identities = 63/167 (37%), Positives = 87/167 (52%), Gaps = 24/167 (14%)
Query: 65 STSHPCFVSRPCLNGGTCH--------MLSRDT-------------YECTCQVGFTGKEC 103
S H V PC NGG+C + SR++ + C C G+ G C
Sbjct: 3800 SVDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWC 3859
Query: 104 QWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNL 162
+ D CL PC +G TC + FSC C GFTG+ CE D+NEC + C++G C N
Sbjct: 3860 EIDIDECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINEC-LQSPCKNGAICQNF 3918
Query: 163 PGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
PGS+ C C G+TG+ C+S C +PC NGG+C Q+G ++ C+C
Sbjct: 3919 PGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSC-QSGVDSYYCHC 3964
Score = 117 bits (294), Expect = 7e-27
Identities = 63/175 (36%), Positives = 85/175 (48%), Gaps = 25/175 (14%)
Query: 27 DPCEKNRCQNGGTC--------------------VAQAMLGKATCRCASGFTGEDCQYST 66
D C CQNGG+C VA L C+C G+ G C+
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863
Query: 67 SHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVAN 125
C S PC +GGTCH L + C+C GFTG+ C+ + CL PC NG+ C
Sbjct: 3864 DE-CLPS-PCHSGGTCHNLVGG-FSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPG 3920
Query: 126 QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
F+C C TG+TG+ CE+ VN C+ C +GG+C + SY C C G G++C+
Sbjct: 3921 SFNCVCKTGYTGKMCESSVNYCEC-NPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 3974
Score = 95.1 bits (235), Expect = 5e-20
Identities = 47/132 (35%), Positives = 70/132 (53%), Gaps = 7/132 (5%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
CKC G+ G +C+ D C + C +GGTC ++G +C C GFTG C+ + C
Sbjct: 3848 CKCLPGYAGSWCEIDIDECLPSPCHSGGTC--HNLVGGFSCSCPDGFTGRACERDINE-C 3904
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSC 129
S PC NG C ++ C C+ G+TGK C+ + + C +PC NG +C + + + C
Sbjct: 3905 LQS-PCKNGAICQNFP-GSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYC 3962
Query: 130 KCLTGFTGQKCE 141
C G G+ CE
Sbjct: 3963 HCPFGVFGKHCE 3974
Score = 52.8 bits (125), Expect = 3e-07
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 23/95 (24%)
Query: 136 TGQKCETDVNECDIPGHCQHGGTCL-------------NLP---------GSYQCQCLQG 173
+G K E+ ++ + G CQ+GG+CL +LP + C+CL G
Sbjct: 3794 SGVKVESVDHDSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPG 3853
Query: 174 FTGQYCDSLYVPCAPSPCVNGGTCRQ-TGDFTFEC 207
+ G +C+ C PSPC +GGTC G F+ C
Sbjct: 3854 YAGSWCEIDIDECLPSPCHSGGTCHNLVGGFSCSC 3888
Score = 47.8 bits (112), Expect = 8e-06
Identities = 29/101 (28%), Positives = 36/101 (35%), Gaps = 19/101 (18%)
Query: 27 DPCEKNRCQNGGTCVAQAMLGKATC-------RCASGFTGEDCQYSTSHPCFVSRPCLNG 79
DP K C+ C + G C RC DC S PC NG
Sbjct: 4391 DPSVKIGCRGPNICASNPCWGDLLCINQWYAYRCVPP---GDC---------ASHPCQNG 4438
Query: 80 GTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC 120
G+C + C+C TG+ C+ ACL C G C
Sbjct: 4439 GSCEPGLHSGFTCSCPDSHTGRTCEMVVACLGVLCPQGKVC 4479
Score = 45.1 bits (105), Expect = 5e-05
Identities = 16/33 (48%), Positives = 21/33 (63%)
Query: 153 CQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP 185
CQHGGTC++ QC C +G TG+YC+ P
Sbjct: 4171 CQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTP 4203
Score = 40.4 bits (93), Expect = 0.001
Identities = 23/67 (34%), Positives = 30/67 (44%), Gaps = 4/67 (5%)
Query: 109 CLSHPCANGSTCTT-VANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC-LNLPGSY 166
C SHPC NG +C + + F+C C TG+ CE V + C G C P +
Sbjct: 4430 CASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMVVACLGV--LCPQGKVCKAGSPAGH 4487
Query: 167 QCQCLQG 173
C QG
Sbjct: 4488 VCVLSQG 4494
Score = 36.6 bits (83), Expect = 0.019
Identities = 15/37 (40%), Positives = 18/37 (48%)
Query: 108 ACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDV 144
AC PC +G TC + C C G TG+ CE V
Sbjct: 4165 ACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSV 4201
Score = 34.7 bits (78), Expect = 0.073
Identities = 16/52 (30%), Positives = 26/52 (50%), Gaps = 2/52 (3%)
Query: 16 EGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTS 67
+G L + + C ++ CQ+GGTC+ C C G TG+ C+ S +
Sbjct: 4153 QGILDQCPRLEGACTRSPCQHGGTCM--DYWSWQQCHCKEGLTGKYCEKSVT 4202
Score = 32.7 bits (73), Expect = 0.28
Identities = 15/41 (36%), Positives = 18/41 (43%), Gaps = 1/41 (2%)
Query: 23 CQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQ 63
C C + CQNGG+C G TC C TG C+
Sbjct: 4424 CVPPGDCASHPCQNGGSCEPGLHSG-FTCSCPDSHTGRTCE 4463
Score = 31.6 bits (70), Expect = 0.62
Identities = 14/30 (46%), Positives = 18/30 (60%), Gaps = 1/30 (3%)
Query: 75 PCLNGGTCHMLSRDTYECTCQVGFTGKECQ 104
PC +GGTC M +C C+ G TGK C+
Sbjct: 4170 PCQHGGTC-MDYWSWQQCHCKEGLTGKYCE 4198
Score = 31.6 bits (70), Expect = 0.62
Identities = 23/91 (25%), Positives = 36/91 (39%), Gaps = 9/91 (9%)
Query: 135 FTGQKCETDVNECD--IPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVP---CAPS 189
F+G+ +++ D + C+ C + P C+ + C VP CA
Sbjct: 4378 FSGKHSLASISKTDPSVKIGCRGPNICASNPCWGDLLCINQWYAYRC----VPPGDCASH 4433
Query: 190 PCVNGGTCRQTGDFTFECNCLPETVRRGTEL 220
PC NGG+C F C+C R E+
Sbjct: 4434 PCQNGGSCEPGLHSGFTCSCPDSHTGRTCEM 4464
Score = 29.6 bits (65), Expect = 2.4
Identities = 16/43 (37%), Positives = 20/43 (46%), Gaps = 2/43 (4%)
Query: 167 QCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
Q QG Q C L C SPC +GGTC + +C+C
Sbjct: 4148 QALAAQGILDQ-CPRLEGACTRSPCQHGGTCMDYWSWQ-QCHC 4188
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 117 bits (294), Expect = 7e-27
Identities = 57/186 (30%), Positives = 93/186 (50%), Gaps = 10/186 (5%)
Query: 29 CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS-- 86
C + C+N GTC Q + C C + G+DC + + PC +GGTCH+
Sbjct: 920 CLSSPCKNNGTCT-QDPVELYRCACPYSYKGKDCTVPIN--TCIQNPCQHGGTCHLSDSH 976
Query: 87 RDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVN 145
+D + C+C +GF G+ C+ D C + C N +TC N + C C +TG+ C+ ++
Sbjct: 977 KDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVID 1036
Query: 146 ECDIP--GHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDF 203
C +P CQH C+ L + C+C+ G++G+ C++ C C +G C T +
Sbjct: 1037 HC-VPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTIN- 1094
Query: 204 TFECNC 209
+ C C
Sbjct: 1095 GYTCTC 1100
Score = 110 bits (274), Expect = 1e-24
Identities = 59/180 (32%), Positives = 84/180 (46%), Gaps = 13/180 (7%)
Query: 12 CKCPEGFLGEYCQ-HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPC 70
C CP GF G+ C+ + D CE N C+N TCV + C C +TGE C H
Sbjct: 982 CSCPLGFEGQRCEINPDDCEDNDCENNATCVDG--INNYVCICPPNYTGELCDEVIDHCV 1039
Query: 71 FVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFSC 129
C + C L + + C C G++GK C+ D C++H C +G+ C N ++C
Sbjct: 1040 PELNLCQHEAKCIPLDKG-FSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTC 1098
Query: 130 KCLTGFTGQKCE-------TDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSL 182
C GF+G CE + CD CQ+G C+ + C+C GF G C+ L
Sbjct: 1099 TCPQGFSGPFCEHPPPMVLLQTSPCD-QYECQNGAQCIVVQQEPTCRCPPGFAGPRCEKL 1157
Score = 74.3 bits (181), Expect = 8e-14
Identities = 42/110 (38%), Positives = 52/110 (47%), Gaps = 8/110 (7%)
Query: 107 DACLSHPCANGSTCT-TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGS 165
+ACLS PC N TCT + C C + G+ C +N C I CQHGGTC +L S
Sbjct: 918 NACLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINTC-IQNPCQHGGTC-HLSDS 975
Query: 166 ----YQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
+ C C GF GQ C+ C + C N TC G + C C P
Sbjct: 976 HKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATC-VDGINNYVCICPP 1024
Score = 69.7 bits (169), Expect = 2e-12
Identities = 34/105 (32%), Positives = 49/105 (46%), Gaps = 7/105 (6%)
Query: 80 GTCHMLSRDTYECTCQVGFTGKEC--QWTDACLSHPCANGSTCTTVANQFSCKCLTGFTG 137
G C + +D+ C C+ G+TG C + D CL H C +G C + CKC G+ G
Sbjct: 1341 GLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHGK-CVATGTSYMCKCAEGYGG 1399
Query: 138 QKCET---DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
C+ N C C HG ++ G C C GF+G++C
Sbjct: 1400 DLCDNKNDSANACSA-FKCHHGQCHISDQGEPYCLCQPGFSGEHC 1443
Score = 68.2 bits (165), Expect = 6e-12
Identities = 42/150 (28%), Positives = 63/150 (42%), Gaps = 12/150 (8%)
Query: 1 MCVTYHNGTGYCKCPEGFLGEYCQH--RDPCEKNRCQNGGTCVAQAMLGKATCRCASGFT 58
+C + + C+C G+ G C RDPC +RC +G CVA C+CA G+
Sbjct: 1342 LCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRCHHG-KCVATGT--SYMCKCAEGYG 1398
Query: 59 GEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPC---- 114
G+ C S + G CH+ + C CQ GF+G+ CQ + CL
Sbjct: 1399 GDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQENPCLGQVVREVI 1458
Query: 115 ---ANGSTCTTVANQFSCKCLTGFTGQKCE 141
++C T + +C G Q C+
Sbjct: 1459 RRQKGYASCATASKVPIMECRGGCGPQCCQ 1488
Score = 49.7 bits (117), Expect = 2e-06
Identities = 29/101 (28%), Positives = 44/101 (43%), Gaps = 8/101 (7%)
Query: 51 CRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQ----WT 106
C C G+TG C PC R + G C + + +Y C C G+ G C
Sbjct: 1353 CECRPGWTGPLCDQEARDPCLGHR--CHHGKC-VATGTSYMCKCAEGYGGDLCDNKNDSA 1409
Query: 107 DACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNEC 147
+AC + C +G + + C C GF+G+ C+ + N C
Sbjct: 1410 NACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
Score = 49.3 bits (116), Expect = 3e-06
Identities = 28/101 (27%), Positives = 45/101 (44%), Gaps = 5/101 (4%)
Query: 114 CANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQG 173
C +G + + C+C G+TG C+ + + + GH H G C+ SY C+C +G
Sbjct: 1338 CKHGLCRSVEKDSVVCECRPGWTGPLCDQEARDPCL-GHRCHHGKCVATGTSYMCKCAEG 1396
Query: 174 FTGQYCDS---LYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
+ G CD+ C+ C + G C + C C P
Sbjct: 1397 YGGDLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQP 1436
>gi|148886692 FAT tumor suppressor homolog 3 [Homo sapiens]
Length = 4557
Score = 115 bits (289), Expect = 3e-26
Identities = 48/106 (45%), Positives = 65/106 (61%), Gaps = 2/106 (1%)
Query: 75 PCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFSCKCLT 133
PC +GG+C L Y+CTC FTG+ C+ AC +PC NG +C + N F C C
Sbjct: 4029 PCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITACFPNPCRNGGSCDPIGNTFICNCKA 4088
Query: 134 GFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYC 179
G TG CE D+NEC+ C++GG+C+N+ GS+ C C G+ GQYC
Sbjct: 4089 GLTGVTCEEDINECE-REECENGGSCVNVFGSFLCNCTPGYVGQYC 4133
Score = 89.0 bits (219), Expect = 3e-18
Identities = 44/115 (38%), Positives = 60/115 (52%), Gaps = 5/115 (4%)
Query: 27 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 86
D C+++ CQ+GG+C G C C S FTG +C+ S CF PC NGG+C +
Sbjct: 4023 DACKRSPCQHGGSCTGLPS-GGYQCTCLSQFTGRNCE-SEITACF-PNPCRNGGSCDPIG 4079
Query: 87 RDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKC 140
+T+ C C+ G TG C+ + C C NG +C V F C C G+ GQ C
Sbjct: 4080 -NTFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFGSFLCNCTPGYVGQYC 4133
Score = 87.0 bits (214), Expect = 1e-17
Identities = 39/108 (36%), Positives = 59/108 (54%), Gaps = 3/108 (2%)
Query: 105 WTDACLSHPCANGSTCTTV-ANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLP 163
+ DAC PC +G +CT + + + C CL+ FTG+ CE+++ C P C++GG+C +
Sbjct: 4021 YPDACKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCESEITAC-FPNPCRNGGSCDPIG 4079
Query: 164 GSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLP 211
++ C C G TG C+ C C NGG+C +F CNC P
Sbjct: 4080 NTFICNCKAGLTGVTCEEDINECEREECENGGSCVNVFG-SFLCNCTP 4126
Score = 46.6 bits (109), Expect = 2e-05
Identities = 20/55 (36%), Positives = 28/55 (50%), Gaps = 3/55 (5%)
Query: 9 TGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDC 62
T C C G G C+ + CE+ C+NGG+CV + G C C G+ G+ C
Sbjct: 4081 TFICNCKAGLTGVTCEEDINECEREECENGGSCV--NVFGSFLCNCTPGYVGQYC 4133
Score = 31.2 bits (69), Expect = 0.81
Identities = 12/34 (35%), Positives = 17/34 (50%)
Query: 186 CAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTE 219
C SPC +GG+C ++C CL + R E
Sbjct: 4025 CKRSPCQHGGSCTGLPSGGYQCTCLSQFTGRNCE 4058
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 107 bits (266), Expect = 1e-23
Identities = 78/221 (35%), Positives = 97/221 (43%), Gaps = 25/221 (11%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGED 61
C+ G C C + GE C+ C N CQNGGTCV ++LG+ TC CA GFTG +
Sbjct: 4227 CILNEKGDLRCHCWPSYSGERCEVNH-CS-NYCQNGGTCVP-SVLGRPTCSCALGFTGPN 4283
Query: 62 CQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCT 121
C + C NGGTC + + + C CQ +TG CQ+ H C N +CT
Sbjct: 4284 CGKTVCEDF-----CQNGGTCIVTAGNQPYCHCQPEYTGDRCQY--YVCHHYCVNSESCT 4336
Query: 122 TVAN-QFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQ--CQCLQGFTGQY 178
+ C C T + G KCE D +C C HGG C+ S C C G
Sbjct: 4337 IGDDGSVECVCPTRYEGPKCEVD--KC---VRC-HGGHCIINKDSEDIFCNCTNGKIASS 4390
Query: 179 CDSLYVPCAPSPCVNGGTCRQTGDFTFECNCLPETVRRGTE 219
C C NGGTC Q T CL T GT+
Sbjct: 4391 CQ-----LCDGYCYNGGTC-QLDPETNVPVCLCSTNWSGTQ 4425
Score = 86.3 bits (212), Expect = 2e-17
Identities = 70/211 (33%), Positives = 91/211 (43%), Gaps = 35/211 (16%)
Query: 12 CKCPEG--FLGEYCQHR----DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYS 65
C CPEG + C D C K C+NGG C+ G C C ++GE C+ +
Sbjct: 4194 CVCPEGKYLINGTCNDDSLLDDSC-KLTCENGGRCILNEK-GDLRCHCWPSYSGERCEVN 4251
Query: 66 TSHPCFVSRPCLNGGTC--HMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC-TT 122
S C NGGTC +L R T C+C +GFTG C T C C NG TC T
Sbjct: 4252 -----HCSNYCQNGGTCVPSVLGRPT--CSCALGFTGPNCGKT-VCEDF-CQNGGTCIVT 4302
Query: 123 VANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC-LNLPGSYQCQCLQGFTGQYCDS 181
NQ C C +TG +C+ V +C + +C + GS +C C + G C+
Sbjct: 4303 AGNQPYCHCQPEYTGDRCQYYV----CHHYCVNSESCTIGDDGSVECVCPTRYEGPKCE- 4357
Query: 182 LYVPCAPSPCV--NGGTCRQTGDF-TFECNC 209
CV +GG C D CNC
Sbjct: 4358 ------VDKCVRCHGGHCIINKDSEDIFCNC 4382
Score = 80.5 bits (197), Expect = 1e-15
Identities = 54/165 (32%), Positives = 72/165 (43%), Gaps = 13/165 (7%)
Query: 49 ATCRCASG--FTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT 106
ATC C G C + C NGG C + + C C ++G+ C+
Sbjct: 4192 ATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSYSGERCE-V 4250
Query: 107 DACLSHPCANGSTCT-TVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGS 165
+ C S+ C NG TC +V + +C C GFTG C V E CQ+GGTC+ G+
Sbjct: 4251 NHC-SNYCQNGGTCVPSVLGRPTCSCALGFTGPNCGKTVCE----DFCQNGGTCIVTAGN 4305
Query: 166 Y-QCQCLQGFTGQYCDSLYVPCAPSPCVNGGTCRQTGDFTFECNC 209
C C +TG C Y C CVN +C D + EC C
Sbjct: 4306 QPYCHCQPEYTGDRCQ--YYVC-HHYCVNSESCTIGDDGSVECVC 4347
Score = 67.0 bits (162), Expect = 1e-11
Identities = 48/173 (27%), Positives = 64/173 (36%), Gaps = 41/173 (23%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGED 61
CV G C C GF G C + CE + CQNGGTC+ A + C C +TG+
Sbjct: 4263 CVPSVLGRPTCSCALGFTGPNCG-KTVCE-DFCQNGGTCIVTAG-NQPYCHCQPEYTGDR 4319
Query: 62 CQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHP-------- 113
CQY H C+N +C + + EC C + G +C+ H
Sbjct: 4320 CQYYVCH-----HYCVNSESCTIGDDGSVECVCPTRYEGPKCEVDKCVRCHGGHCIINKD 4374
Query: 114 -----------------------CANGSTCTT--VANQFSCKCLTGFTGQKCE 141
C NG TC N C C T ++G +CE
Sbjct: 4375 SEDIFCNCTNGKIASSCQLCDGYCYNGGTCQLDPETNVPVCLCSTNWSGTQCE 4427
Score = 55.8 bits (133), Expect = 3e-08
Identities = 40/168 (23%), Positives = 66/168 (39%), Gaps = 40/168 (23%)
Query: 32 NRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYE 91
+RC+N C+ + C + C ++ +RPC +D +
Sbjct: 3721 HRCRNNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYK---ARPC---------KKDEFA 3768
Query: 92 CT----------------CQVGFTGKEC-----QWTDACLSHPCANGSTCTTVANQFSCK 130
C+ C G + C ++T +PC + + C + C+
Sbjct: 3769 CSNKKCIPMDLQCDRLDDCGDGSDEQGCRIAPTEYTCEDNVNPCGDDAYCNQIKTSVFCR 3828
Query: 131 CLTGFT----GQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF 174
C GF ++CE D+NEC + G C H C+N+ GSY+C C Q F
Sbjct: 3829 CKPGFQRNMKNRQCE-DLNECLVFGTCSH--QCINVEGSYKCVCDQNF 3873
Score = 54.3 bits (129), Expect = 9e-08
Identities = 47/154 (30%), Positives = 63/154 (40%), Gaps = 15/154 (9%)
Query: 34 CQNGGTCVAQAML--GKATCRCASGFTGEDCQYSTSHPCFVSR-PCLNGGTC-HMLSRDT 89
C + TCV+Q+ L G C S + + C C ++ CL C H+
Sbjct: 39 CHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCVHLSQLCN 98
Query: 90 YECTCQVGFT-GKECQ-WTDACLSHPCANGSTCTTVANQFSCKCLTGFT----GQKCETD 143
C G+ G CQ C C CT V N C C GF G+ C+ D
Sbjct: 99 GVLDCPDGYDEGVHCQELLSNCQQLNCQY--KCTMVRNSTRCYCEDGFEITEDGRSCK-D 155
Query: 144 VNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQ 177
+EC + G C TC N GSY C C++G+ Q
Sbjct: 156 QDECAVYGTCSQ--TCRNTHGSYTCSCVEGYLMQ 187
Score = 41.2 bits (95), Expect = 8e-04
Identities = 32/110 (29%), Positives = 47/110 (42%), Gaps = 15/110 (13%)
Query: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGST-CTTVANQFS 128
C R +GG C ++D C G + C + CLS + S C + +
Sbjct: 2898 CKNGRCIPSGGLCD--NKDD----CGDGSDERNCHINE-CLSKKVSGCSQDCQDLPVSYK 2950
Query: 129 CKCLTGFT----GQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF 174
CKC GF G+ C D++EC C C+N G+Y+C C G+
Sbjct: 2951 CKCWPGFQLKDDGKTC-VDIDECSSGFPCSQ--QCINTYGTYKCLCTDGY 2997
Score = 29.3 bits (64), Expect = 3.1
Identities = 24/86 (27%), Positives = 34/86 (39%), Gaps = 15/86 (17%)
Query: 131 CLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF----TGQYCDSLYVPC 186
C G + C +NEC C +LP SY+C+C GF G+ C +
Sbjct: 2916 CGDGSDERNCH--INECLSKKVSGCSQDCQDLPVSYKCKCWPGFQLKDDGKTCVDI---- 2969
Query: 187 APSPCVNGGTCRQ---TGDFTFECNC 209
C +G C Q T++C C
Sbjct: 2970 --DECSSGFPCSQQCINTYGTYKCLC 2993
Score = 28.9 bits (63), Expect = 4.0
Identities = 40/177 (22%), Positives = 57/177 (32%), Gaps = 46/177 (25%)
Query: 14 CPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVS 73
C + E C+ + K+ G CV+ CA G +C+ S S F
Sbjct: 3501 CSDNSDEENCKPQTCTLKDFLCANGDCVSSRFWCDGDFDCADGSDERNCETSCSKDQF-- 3558
Query: 74 RPCLNGGTCHMLSRDTYECTCQVGFTGKECQ-------------WTDACLS--------H 112
C NG + C+ G K C+ +D C+S +
Sbjct: 3559 -RCSNGQCIPAKWKCDGHEDCKYGEDEKSCEPASPTCSSREYICASDGCISASLKCNGEY 3617
Query: 113 PCANGS---TCTTVA--NQFSCK-----------------CLTGFTGQKCETDVNEC 147
CA+GS C T +QF CK C+ G + CE N C
Sbjct: 3618 DCADGSDEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENCERGGNIC 3674
Score = 27.7 bits (60), Expect = 9.0
Identities = 21/73 (28%), Positives = 25/73 (34%), Gaps = 7/73 (9%)
Query: 146 ECDIPGHCQHGGT---CLNLPGSYQCQCLQG--FTGQYC--DSLYVPCAPSPCVNGGTCR 198
+ D+P C CL P C C +G C DSL C NGG C
Sbjct: 4169 QLDLPNPCLDLACEFLCLLNPSGATCVCPEGKYLINGTCNDDSLLDDSCKLTCENGGRCI 4228
Query: 199 QTGDFTFECNCLP 211
C+C P
Sbjct: 4229 LNEKGDLRCHCWP 4241
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 104 bits (260), Expect = 6e-23
Identities = 72/211 (34%), Positives = 92/211 (43%), Gaps = 44/211 (20%)
Query: 33 RCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYEC 92
+C NGG+C A + CRC +TG+ C+ C+ C NGGTC C
Sbjct: 4203 QCFNGGSCFLNARR-QPKCRCQPRYTGDKCELDQ---CW--EHCRNGGTCAASPSGMPTC 4256
Query: 93 TCQVGFTGKECQWTDACLSHPCANGSTCTT-VANQFSCKCLTGFTGQKCETDVNECDIPG 151
C GFTG +C T + CAN STCT NQ C+CL GF G +C+ +C G
Sbjct: 4257 RCPTGFTGPKC--TQQVCAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQ--YRQCS--G 4310
Query: 152 HCQHGGTC-LNLPGSYQCQCLQGFTGQYCD-----------------SLYVPC------- 186
+C++ GTC + GS QC+C F G C+ S V C
Sbjct: 4311 YCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGACVVNKQSGDVTCNCTDGRV 4370
Query: 187 APS------PCVNGGTCRQTGDFTFECNCLP 211
APS C NGG+C EC C P
Sbjct: 4371 APSCLTCVGHCSNGGSCTMNSKMMPECQCPP 4401
Score = 102 bits (254), Expect = 3e-22
Identities = 67/203 (33%), Positives = 94/203 (46%), Gaps = 26/203 (12%)
Query: 22 YCQHR-----DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQY--STSHPCFVSR 74
Y QH+ +PC++ +C+ C+ TC C S + P R
Sbjct: 4139 YHQHKQPEVTNPCDRKKCE--WLCLLSPSGPVCTCPNGKRLDNGTCVPVPSPTPPPDAPR 4196
Query: 75 P------CLNGGTCHMLSRDTYECTCQVGFTGKECQWTDACLSHPCANGSTC-TTVANQF 127
P C NGG+C + +R +C CQ +TG +C+ D C H C NG TC + +
Sbjct: 4197 PGTCNLQCFNGGSCFLNARRQPKCRCQPRYTGDKCE-LDQCWEH-CRNGGTCAASPSGMP 4254
Query: 128 SCKCLTGFTGQKCETDVNECDIPGHCQHGGTC-LNLPGSYQCQCLQGFTGQYCDSLYVPC 186
+C+C TGFTG KC V G+C + TC +N QC+CL GF G C Y C
Sbjct: 4255 TCRCPTGFTGPKCTQQV----CAGYCANNSTCTVNQGNQPQCRCLPGFLGDRCQ--YRQC 4308
Query: 187 APSPCVNGGTCRQTGDFTFECNC 209
+ C N GTC+ D + +C C
Sbjct: 4309 S-GYCENFGTCQMAADGSRQCRC 4330
Score = 89.4 bits (220), Expect = 3e-18
Identities = 57/182 (31%), Positives = 73/182 (40%), Gaps = 21/182 (11%)
Query: 2 CVTYHNGTGYCKCPEGFLGEYCQHRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGED 61
C +G C+CP GF G C + C C N TC + CRC GF G+
Sbjct: 4246 CAASPSGMPTCRCPTGFTGPKCTQQ-VCA-GYCANNSTCTVNQG-NQPQCRCLPGFLGDR 4302
Query: 62 CQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT--DACLSHPCANGST 119
CQY S C N GTC M + + +C C F G C+ CL C
Sbjct: 4303 CQYRQC-----SGYCENFGTCQMAADGSRQCRCTAYFEGSRCEVNKCSRCLEGAC----V 4353
Query: 120 CTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTC-LNLPGSYQCQCLQGFTGQY 178
+ +C C G C T V GHC +GG+C +N +CQC TG
Sbjct: 4354 VNKQSGDVTCNCTDGRVAPSCLTCV------GHCSNGGSCTMNSKMMPECQCPPHMTGPR 4407
Query: 179 CD 180
C+
Sbjct: 4408 CE 4409
Score = 47.4 bits (111), Expect = 1e-05
Identities = 42/160 (26%), Positives = 60/160 (37%), Gaps = 26/160 (16%)
Query: 33 RCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFV---------SRPCLNGG-TC 82
RC+N C+ T C G EDC+ T+H ++ CL+ C
Sbjct: 3702 RCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRNQRCLSSSLRC 3761
Query: 83 HML-----SRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQFSCKCLTGF-- 135
+M D +C+ T C T+A + C + + C C C +GF
Sbjct: 3762 NMFDDCGDGSDEEDCSIDPKLT--SCA-TNASI---CGDEARCVRTEKAAYCACRSGFHT 3815
Query: 136 -TGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF 174
GQ D+NEC G C C N G + C C + F
Sbjct: 3816 VPGQPGCQDINECLRFGTCSQ--LCNNTKGGHLCSCARNF 3853
Score = 43.5 bits (101), Expect = 2e-04
Identities = 25/71 (35%), Positives = 35/71 (49%), Gaps = 8/71 (11%)
Query: 109 CLSHPCANGST-CTTVANQFSCKCLTGFT----GQKCETDVNECDIPGHCQHGGTCLNLP 163
CLS + S C + F C+C GF G+ C DV+EC C C+N
Sbjct: 2944 CLSRKLSGCSQDCEDLKIGFKCRCRPGFRLKDDGRTC-ADVDECSTTFPCSQ--RCINTH 3000
Query: 164 GSYQCQCLQGF 174
GSY+C C++G+
Sbjct: 3001 GSYKCLCVEGY 3011
Score = 38.9 bits (89), Expect = 0.004
Identities = 38/152 (25%), Positives = 61/152 (40%), Gaps = 17/152 (11%)
Query: 34 CQNGGTCVAQAML--GKATCRCASGFTGEDCQYSTSHPCFVSRP-CLNGGTCHMLSR--- 87
C++ TC+++ G+ C S E C S + C + CL C +SR
Sbjct: 34 CRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSRLCN 93
Query: 88 DTYECTCQVGFTGKECQWTDA-CLSHPCANGSTCTTVANQFSCKCLTGFT----GQKCET 142
+C G C+ C C + C + +C C + F G+ C+
Sbjct: 94 GVQDCM-DGSDEGPHCRELQGNCSRLGCQHH--CVPTLDGPTCYCNSSFQLQADGKTCK- 149
Query: 143 DVNECDIPGHCQHGGTCLNLPGSYQCQCLQGF 174
D +EC + G C C N GS+ C C++G+
Sbjct: 150 DFDECSVYGTCSQ--LCTNTDGSFICGCVEGY 179
Score = 37.4 bits (85), Expect = 0.011
Identities = 35/165 (21%), Positives = 58/165 (35%), Gaps = 14/165 (8%)
Query: 27 DPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLS 86
DP K C++ C+++A + C E+C+ P S PC N + +
Sbjct: 1105 DPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRP--PSHPCANNTSVCLPP 1162
Query: 87 RDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVANQ-FSCKCLTGFTGQKCETDVN 145
+ G E + D C + C+ + C C G + D +
Sbjct: 1163 DKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCP---LGMELGPDNH 1219
Query: 146 ECDIPGHC----QHGGTCLNLPGSYQCQCLQGFT----GQYCDSL 182
C I +C + C S +C C +G+ G+ C SL
Sbjct: 1220 TCQIQSYCAKHLKCSQKCDQNKFSVKCSCYEGWVLEPDGESCRSL 1264
Score = 29.3 bits (64), Expect = 3.1
Identities = 21/70 (30%), Positives = 30/70 (42%), Gaps = 6/70 (8%)
Query: 135 FTGQKCETDVNECDIP-GHCQHGGTCLNLPGSYQCQCLQGFTGQYCDSLYVPCAPSPCVN 193
+ Q+ + N+C + G C CL PGS QC C + Q D+ V C +P
Sbjct: 795 YDAQQQQVGTNKCRVNNGGCS--SLCLATPGSRQCACAE---DQVLDADGVTCLANPSYV 849
Query: 194 GGTCRQTGDF 203
Q G+F
Sbjct: 850 PPPQCQPGEF 859
Score = 28.1 bits (61), Expect = 6.9
Identities = 20/61 (32%), Positives = 27/61 (44%), Gaps = 14/61 (22%)
Query: 17 GFLGEYCQHRDP------CEKNRCQNGGTCVAQAMLGKA----TCRCASGFT----GEDC 62
G L Y Q R P CE ++ G C +L + TCRC SGF+ G+ C
Sbjct: 460 GALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSC 519
Query: 63 Q 63
+
Sbjct: 520 K 520
>gi|126091152 cubilin [Homo sapiens]
Length = 3623
Score = 102 bits (255), Expect = 2e-22
Identities = 72/221 (32%), Positives = 105/221 (47%), Gaps = 24/221 (10%)
Query: 8 GTGYC-KCPEGFLGE--YCQHRDPCEKNRCQNGGTCVAQAML-----GKATCR-CASGFT 58
G+ YC CP G+ G C+ + CE N NGG VA + G + C+ C G+
Sbjct: 285 GSFYCGACPTGWQGNGYICEDINECEIN---NGGCSVAPPVECVNTPGSSHCQACPPGYQ 341
Query: 59 GEDCQYSTSHPCFVSRP-CLNGGTCHMLSRDTYECTCQVGFTGKE------CQWTDACLS 111
G+ + + C VS C +C CTC G+TG Q ++ CLS
Sbjct: 342 GDGRVCTLTDICSVSNGGCHPDASCSSTLGSLPLCTCLPGYTGNGYGPNGCVQLSNICLS 401
Query: 112 HPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCL 171
HPC NG TV+ F CKC +G+TG C ++NEC + C +GGTC++ S+ C+C
Sbjct: 402 HPCLNGQCIDTVSGYF-CKCDSGWTGVNCTENINEC-LSNPCLNGGTCVDGVDSFSCECT 459
Query: 172 QGFTGQYCDSLYVPCAPS-PCVNGGTCRQTGD--FTFECNC 209
+ +TG C C S +NG ++ D + + NC
Sbjct: 460 RLWTGALCQVPQQVCGESLSGINGSFSYRSPDVGYVHDVNC 500
Score = 83.6 bits (205), Expect = 1e-16
Identities = 45/113 (39%), Positives = 57/113 (50%), Gaps = 13/113 (11%)
Query: 109 CLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDI----PGHCQHGGTCLNLPG 164
C S+PC NG TC + + F C C + G C DVNEC+I P CQ+GGTC+N G
Sbjct: 136 CSSNPCQNGGTCLNLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTCVNTMG 195
Query: 165 SYQCQCLQGFTGQYCDSLYVPC---APSPCVNGGTC-----RQTGDFTFECNC 209
SY C C G C S Y C + + CV+ G C Q G+ + C C
Sbjct: 196 SYSCHCPPETYGPQCASKYDDCEGGSVARCVH-GICEDLMREQAGEPKYSCVC 247
Score = 59.3 bits (142), Expect = 3e-09
Identities = 54/194 (27%), Positives = 73/194 (37%), Gaps = 38/194 (19%)
Query: 29 CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSH-PCFVSRP--CLNGGTCHML 85
C N CQNGGTC+ + C C + G C + + P C NGGTC +
Sbjct: 136 CSSNPCQNGGTCL--NLHDSFFCICPPQWKGPLCSADVNECEIYSGTPLSCQNGGTC-VN 192
Query: 86 SRDTYECTCQVGFTGKECQWTDACLSHPCANGSTCTTVAN-------------QFSCKCL 132
+ +Y C C G +C A C GS V ++SC C
Sbjct: 193 TMGSYSCHCPPETYGPQC----ASKYDDCEGGSVARCVHGICEDLMREQAGEPKYSCVCD 248
Query: 133 TGF----TGQKCETDVNECDI-PGHCQHGGTCLNLPGSYQC-QCLQGF--TGQYCDSLYV 184
G+ C D +EC PG C C N GS+ C C G+ G C+ +
Sbjct: 249 AGWMFSPNSPACTLDRDECSFQPGPCSTLVQCFNTQGSFYCGACPTGWQGNGYICEDI-- 306
Query: 185 PCAPSPC-VNGGTC 197
+ C +N G C
Sbjct: 307 ----NECEINNGGC 316
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.138 0.501
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,319,766
Number of Sequences: 37866
Number of extensions: 668987
Number of successful extensions: 7404
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 244
Number of HSP's successfully gapped in prelim test: 187
Number of HSP's that attempted gapping in prelim test: 1375
Number of HSP's gapped (non-prelim): 2210
length of query: 236
length of database: 18,247,518
effective HSP length: 99
effective length of query: 137
effective length of database: 14,498,784
effective search space: 1986333408
effective search space used: 1986333408
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 60 (27.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.