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Search of human proteins with 4557751
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4557751 MHC class I polypeptide-related sequence A [Homo
sapiens]
(383 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4557751 MHC class I polypeptide-related sequence A [Homo sapi... 796 0.0
gi|167857788 MHC class I polypeptide-related sequence B [Homo sa... 635 0.0
gi|52630342 major histocompatibility complex, class I, C precurs... 143 3e-34
gi|62912479 major histocompatibility complex, class I, E precurs... 142 4e-34
gi|24797067 major histocompatibility complex, class I, A precurs... 142 7e-34
gi|149158702 major histocompatibility complex, class I, F isofor... 140 2e-33
gi|149158698 major histocompatibility complex, class I, F isofor... 140 2e-33
gi|17986001 major histocompatibility complex, class I, B precurs... 140 2e-33
gi|89063265 PREDICTED: similar to MHC class I antigen [Homo sapi... 140 2e-33
gi|4504377 hemochromatosis protein isoform 1 precursor [Homo sap... 134 1e-31
gi|4504415 major histocompatibility complex, class I, G precurso... 134 2e-31
gi|4504417 major histocompatibility complex, class I-related [Ho... 131 9e-31
gi|21040353 hemochromatosis protein isoform 9 precursor [Homo sa... 130 2e-30
gi|21040347 hemochromatosis protein isoform 6 precursor [Homo sa... 120 2e-27
gi|21040349 hemochromatosis protein isoform 7 precursor [Homo sa... 117 2e-26
gi|21040351 hemochromatosis protein isoform 8 precursor [Homo sa... 103 3e-22
gi|4502337 alpha-2-glycoprotein 1, zinc [Homo sapiens] 98 1e-20
gi|21040343 hemochromatosis protein isoform 4 precursor [Homo sa... 88 1e-17
gi|21040355 hemochromatosis protein isoform 10 precursor [Homo s... 87 2e-17
gi|209862839 Fc fragment of IgG, receptor, transporter, alpha [H... 84 2e-16
gi|4758346 Fc fragment of IgG, receptor, transporter, alpha [Hom... 84 2e-16
gi|21040341 hemochromatosis protein isoform 3 precursor [Homo sa... 80 2e-15
gi|149158700 major histocompatibility complex, class I, F isofor... 70 3e-12
gi|4502649 CD1D antigen precursor [Homo sapiens] 65 8e-11
gi|110618227 CD1C antigen precursor [Homo sapiens] 59 1e-08
gi|110618224 CD1A antigen precursor [Homo sapiens] 56 6e-08
gi|21040249 retinoic acid early transcript 1E [Homo sapiens] 55 8e-08
gi|4504399 major histocompatibility complex, class II, DM beta p... 54 2e-07
gi|13375656 UL16 binding protein 3 [Homo sapiens] 54 2e-07
gi|144953876 signal-regulatory protein beta 1 isoform 1 precurso... 51 2e-06
>gi|4557751 MHC class I polypeptide-related sequence A [Homo
sapiens]
Length = 383
Score = 796 bits (2056), Expect = 0.0
Identities = 383/383 (100%), Positives = 383/383 (100%)
Query: 1 MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCD 60
MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCD
Sbjct: 1 MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCD 60
Query: 61 RQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCE 120
RQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCE
Sbjct: 61 RQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCE 120
Query: 121 IHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHY 180
IHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHY
Sbjct: 121 IHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHY 180
Query: 181 HAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWR 240
HAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWR
Sbjct: 181 HAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWR 240
Query: 241 QDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKV 300
QDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKV
Sbjct: 241 QDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKV 300
Query: 301 LVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHR 360
LVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHR
Sbjct: 301 LVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHR 360
Query: 361 DATQLGFQPLMSDLGSTGSTEGA 383
DATQLGFQPLMSDLGSTGSTEGA
Sbjct: 361 DATQLGFQPLMSDLGSTGSTEGA 383
>gi|167857788 MHC class I polypeptide-related sequence B [Homo
sapiens]
Length = 383
Score = 635 bits (1637), Expect = 0.0
Identities = 316/382 (82%), Positives = 329/382 (86%)
Query: 1 MGLGPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCD 60
MGLG V L LA FPFAPP AAAEPHSLRYNL VLS DGSVQSGFL E HLDGQPFLR D
Sbjct: 1 MGLGRVLLFLAVAFPFAPPAAAAEPHSLRYNLMVLSQDGSVQSGFLAEGHLDGQPFLRYD 60
Query: 61 RQKCRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCE 120
RQK RAKPQGQWAE+VLG KTWD ET DLT NG+DLR TL HIKDQK GLHSLQEIRVCE
Sbjct: 61 RQKRRAKPQGQWAENVLGAKTWDTETEDLTENGQDLRRTLTHIKDQKGGLHSLQEIRVCE 120
Query: 121 IHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHY 180
IHED+STR S+HFYYDGELFLSQNLET+E T+PQSSRAQTLAMNV NF KEDAMKTKTHY
Sbjct: 121 IHEDSSTRGSRHFYYDGELFLSQNLETQESTVPQSSRAQTLAMNVTNFWKEDAMKTKTHY 180
Query: 181 HAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWR 240
AM ADCLQ+L+RYLKSGV +RRTVPPMVNVT SE SEGNITVTCRAS FYP NITL+WR
Sbjct: 181 RAMQADCLQKLQRYLKSGVAIRRTVPPMVNVTCSEVSEGNITVTCRASSFYPRNITLTWR 240
Query: 241 QDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKV 300
QDGVSLSH+TQQWGDVLPDGNGTYQTWVATRI QGEEQRFTCYMEHSGNH THPVPSGK
Sbjct: 241 QDGVSLSHNTQQWGDVLPDGNGTYQTWVATRIRQGEEQRFTCYMEHSGNHGTHPVPSGKA 300
Query: 301 LVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTSAAEGPELVSLQVLDQHPVGTSDHR 360
LVLQS F + A +III V CCKKKTSAAEGPELVSLQVLDQHPVGT DHR
Sbjct: 301 LVLQSQRTDFPYVSAAMPCFVIIIILCVPCCKKKTSAAEGPELVSLQVLDQHPVGTGDHR 360
Query: 361 DATQLGFQPLMSDLGSTGSTEG 382
DA QLGFQPLMS GSTGSTEG
Sbjct: 361 DAAQLGFQPLMSATGSTGSTEG 382
>gi|52630342 major histocompatibility complex, class I, C precursor
[Homo sapiens]
Length = 366
Score = 143 bits (360), Expect = 3e-34
Identities = 103/353 (29%), Positives = 171/353 (48%), Gaps = 37/353 (10%)
Query: 6 VFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC- 64
+ LLL+G A + HS+RY T +S G + F++ ++D F+R D
Sbjct: 9 LLLLLSGGLALTETWACS--HSMRYFDTAVSRPGRGEPRFISVGYVDDTQFVRFDSDAAS 66
Query: 65 -RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIK----DQKEGLHSLQEIRVC 119
R +P+ W E G + WDRET+ + R++L +++ ++G H+LQ + C
Sbjct: 67 PRGEPRAPWVEQE-GPEYWDRETQKYKRQAQADRVSLRNLRGYYNQSEDGSHTLQRMSGC 125
Query: 120 EIHEDNST-RSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKT 178
++ D R YDG+ +++ N + + WT A T A + L E A +
Sbjct: 126 DLGPDGRLLRGYDQSAYDGKDYIALNEDLRSWTA-----ADTAAQITQRKL-EAARAAEQ 179
Query: 179 HYHAMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITL 237
+ C++ LRRYL++G L+R PP +VT S+ T+ C A GFYP ITL
Sbjct: 180 LRAYLEGTCVEWLRRYLENGKETLQRAEPPKTHVTHHPLSDHEATLRCWALGFYPAEITL 239
Query: 238 SWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSG-----NHST 292
+W++DG + DT + + P G+GT+Q W A + G+EQR+TC+M+H G S
Sbjct: 240 TWQRDGEDQTQDT-ELVETRPAGDGTFQKWAAVVVPSGQEQRYTCHMQHEGLQEPLTLSW 298
Query: 293 HPVPSGKVLVLQSHWQTFHVSAVAAAAIFVII-----IFYVRCCKKKTSAAEG 340
P + ++ VA A+ V++ + C++K+S +G
Sbjct: 299 EPSSQPTIPIM---------GIVAGLAVLVVLAVLGAVVTAMMCRRKSSGGKG 342
>gi|62912479 major histocompatibility complex, class I, E precursor
[Homo sapiens]
Length = 358
Score = 142 bits (359), Expect = 4e-34
Identities = 93/293 (31%), Positives = 144/293 (49%), Gaps = 18/293 (6%)
Query: 4 GPVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQK 63
G + LLL+ A + HSL+Y T +S G + F++ ++D F+R D
Sbjct: 4 GTLLLLLSEALALTQTWAGS--HSLKYFHTSVSRPGRGEPRFISVGYVDDTQFVRFDNDA 61
Query: 64 C--RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIK----DQKEGLHSLQEIR 117
R P+ W E G++ WDRETR + R+ L ++ + G H+LQ +
Sbjct: 62 ASPRMVPRAPWMEQE-GSEYWDRETRSARDTAQIFRVNLRTLRGYYNQSEAGSHTLQWMH 120
Query: 118 VCEIHEDNS-TRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKT 176
CE+ D R + F YDG+ +L+ N + + WT A A + DA +
Sbjct: 121 GCELGPDGRFLRGYEQFAYDGKDYLTLNEDLRSWT------AVDTAAQISEQKSNDASEA 174
Query: 177 KTHYHAMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNI 235
+ + C++ L +YL+ G L PP +VT S+ T+ C A GFYP I
Sbjct: 175 EHQRAYLEDTCVEWLHKYLEKGKETLLHLEPPKTHVTHHPISDHEATLRCWALGFYPAEI 234
Query: 236 TLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSG 288
TL+W+QDG + DT + + P G+GT+Q W A + GEEQR+TC+++H G
Sbjct: 235 TLTWQQDGEGHTQDT-ELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEG 286
>gi|24797067 major histocompatibility complex, class I, A precursor
[Homo sapiens]
Length = 365
Score = 142 bits (357), Expect = 7e-34
Identities = 90/291 (30%), Positives = 150/291 (51%), Gaps = 18/291 (6%)
Query: 6 VFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC- 64
+ LLL+G A + HS+RY T +S G + F+ ++D F+R D
Sbjct: 9 LLLLLSGALALTQTWAGS--HSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAAS 66
Query: 65 -RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIK----DQKEGLHSLQEIRVC 119
R +P+ W E G + WD+ETR++ + R+ L ++ + G H++Q + C
Sbjct: 67 QRMEPRAPWIEQE-GPEYWDQETRNVKAQSQTDRVDLGTLRGYYNQSEAGSHTIQIMYGC 125
Query: 120 EIHEDNS-TRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKT 178
++ D R + YDG+ +++ N + + WT A +A + E A + +
Sbjct: 126 DVGSDGRFLRGYRQDAYDGKDYIALNEDLRSWT------AADMAAQITKRKWEAAHEAEQ 179
Query: 179 HYHAMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITL 237
+ C++ LRRYL++G L+RT PP ++T S+ T+ C A GFYP ITL
Sbjct: 180 LRAYLDGTCVEWLRRYLENGKETLQRTDPPKTHMTHHPISDHEATLRCWALGFYPAEITL 239
Query: 238 SWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSG 288
+W++DG + DT + + P G+GT+Q W A + GEEQR+TC+++H G
Sbjct: 240 TWQRDGEDQTQDT-ELVETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEG 289
>gi|149158702 major histocompatibility complex, class I, F isoform 1
precursor [Homo sapiens]
Length = 442
Score = 140 bits (352), Expect = 2e-33
Identities = 94/293 (32%), Positives = 150/293 (51%), Gaps = 22/293 (7%)
Query: 6 VFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC- 64
+ LLL+G A + HSLRY T +S G + ++ ++D FLR D
Sbjct: 6 LLLLLSGALALTDTWAGS--HSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSDAAI 63
Query: 65 -RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHI----KDQKEGLHSLQEIRVC 119
R +P+ W E G + W+ T N + R+ L ++ + G H+LQ + C
Sbjct: 64 PRMEPREPWVEQE-GPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMNGC 122
Query: 120 EIHEDNSTRSSQHFY-YDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLK--EDAMKT 176
++ D H + YDG+ ++S N + + WT A T+A + F + E A +
Sbjct: 123 DMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTA-----ADTVAQITQRFYEAEEYAEEF 177
Query: 177 KTHYHAMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNI 235
+T+ + +CL+ LRRYL++G L+R PP +V S+ T+ C A GFYP I
Sbjct: 178 RTY---LEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEI 234
Query: 236 TLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSG 288
TL+W++DG + DT + + P G+GT+Q W A + GEEQR+TC+++H G
Sbjct: 235 TLTWQRDGEEQTQDT-ELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEG 286
>gi|149158698 major histocompatibility complex, class I, F isoform 2
precursor [Homo sapiens]
Length = 346
Score = 140 bits (352), Expect = 2e-33
Identities = 94/293 (32%), Positives = 150/293 (51%), Gaps = 22/293 (7%)
Query: 6 VFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC- 64
+ LLL+G A + HSLRY T +S G + ++ ++D FLR D
Sbjct: 6 LLLLLSGALALTDTWAGS--HSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSDAAI 63
Query: 65 -RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHI----KDQKEGLHSLQEIRVC 119
R +P+ W E G + W+ T N + R+ L ++ + G H+LQ + C
Sbjct: 64 PRMEPREPWVEQE-GPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMNGC 122
Query: 120 EIHEDNSTRSSQHFY-YDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLK--EDAMKT 176
++ D H + YDG+ ++S N + + WT A T+A + F + E A +
Sbjct: 123 DMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWTA-----ADTVAQITQRFYEAEEYAEEF 177
Query: 177 KTHYHAMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNI 235
+T+ + +CL+ LRRYL++G L+R PP +V S+ T+ C A GFYP I
Sbjct: 178 RTY---LEGECLELLRRYLENGKETLQRADPPKAHVAHHPISDHEATLRCWALGFYPAEI 234
Query: 236 TLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSG 288
TL+W++DG + DT + + P G+GT+Q W A + GEEQR+TC+++H G
Sbjct: 235 TLTWQRDGEEQTQDT-ELVETRPAGDGTFQKWAAVVVPPGEEQRYTCHVQHEG 286
>gi|17986001 major histocompatibility complex, class I, B precursor
[Homo sapiens]
Length = 362
Score = 140 bits (352), Expect = 2e-33
Identities = 100/347 (28%), Positives = 164/347 (47%), Gaps = 26/347 (7%)
Query: 6 VFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC- 64
V LLL+ A + HS+RY T +S G + F++ ++D F+R D
Sbjct: 9 VLLLLSAALALTETWAGS--HSMRYFYTSVSRPGRGEPRFISVGYVDDTQFVRFDSDAAS 66
Query: 65 -RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIK----DQKEGLHSLQEIRVC 119
R +P+ W E G + WDR T+ + R +L +++ + G H+LQ + C
Sbjct: 67 PREEPRAPWIEQE-GPEYWDRNTQIYKAQAQTDRESLRNLRGYYNQSEAGSHTLQSMYGC 125
Query: 120 EIHEDNST-RSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKT 178
++ D R + YDG+ +++ N + + WT A A + E A + +
Sbjct: 126 DVGPDGRLLRGHDQYAYDGKDYIALNEDLRSWT------AADTAAQITQRKWEAAREAEQ 179
Query: 179 HYHAMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITL 237
+ +C++ LRRYL++G L R PP +VT S+ T+ C A GFYP ITL
Sbjct: 180 RRAYLEGECVEWLRRYLENGKDKLERADPPKTHVTHHPISDHEATLRCWALGFYPAEITL 239
Query: 238 SWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPS 297
+W++DG + DT + + P G+ T+Q W A + GEEQR+TC+++H G P P
Sbjct: 240 TWQRDGEDQTQDT-ELVETRPAGDRTFQKWAAVVVPSGEEQRYTCHVQHEG----LPKPL 294
Query: 298 GKVLVLQSHWQTFHVSAVAAAAIFVIIIF----YVRCCKKKTSAAEG 340
S V VA A+ +++ C++K+S +G
Sbjct: 295 TLRWEPSSQSTVPIVGIVAGLAVLAVVVIGAVVAAVMCRRKSSGGKG 341
>gi|89063265 PREDICTED: similar to MHC class I antigen [Homo
sapiens]
Length = 366
Score = 140 bits (352), Expect = 2e-33
Identities = 99/342 (28%), Positives = 157/342 (45%), Gaps = 36/342 (10%)
Query: 15 PFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC--RAKPQGQW 72
P PPG+ HSLRY T +S G + F++ ++D F+R D R +P+ W
Sbjct: 33 PSPPPGS----HSLRYFYTAVSRPGLGEPRFISVGYVDDTQFVRFDSDSANPREEPRAPW 88
Query: 73 AEDVLGNKTWDRETRDLTGNGKDLRMTL----AHIKDQKEGLHSLQEIRVCEIHEDNS-T 127
E G + WD +TR + + R+ L + + G H+LQ + C++ D
Sbjct: 89 MEQE-GPEYWDEQTRIVKDTAQSFRVGLNTLRGYYNQSEAGSHTLQLMYGCDVGPDGRFL 147
Query: 128 RSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADC 187
R YDG +++ N + + WT A A + +E A + + + C
Sbjct: 148 RGFMQDAYDGRDYIALNEDLRSWT------AADTAAQITKRKREAAGAAERQRNYLEGRC 201
Query: 188 LQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSL 246
++ LRRYL++G L R PP +VT SE +T+ C A GFYP I+L+W+++G
Sbjct: 202 VEGLRRYLETGKDALLRADPPKAHVTHHPISEREVTLRCWALGFYPEEISLTWQREGEDQ 261
Query: 247 SHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSH 306
+ D + + P G+GT+Q W A + GEEQR+TC ++H G L
Sbjct: 262 TQD-MELVETRPSGDGTFQKWAALVVPSGEEQRYTCRVQHEGLQEP----------LTLR 310
Query: 307 WQTFHVSAVAAAAIFVIIIFYVRCC------KKKTSAAEGPE 342
W+ S + I +++ V +KK S EG E
Sbjct: 311 WEPPQTSFLIMGIIVGLVLLVVALVAGAVIWRKKRSGREGRE 352
>gi|4504377 hemochromatosis protein isoform 1 precursor [Homo
sapiens]
Length = 348
Score = 134 bits (338), Expect = 1e-31
Identities = 97/331 (29%), Positives = 152/331 (45%), Gaps = 25/331 (7%)
Query: 5 PVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC 64
P LLL + G HSL Y S S F ++D Q F+ D +
Sbjct: 7 PALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESR 66
Query: 65 RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRM---TLAHIKDQKEGLHSLQEIRVCEI 121
R +P+ W + ++ W + ++ L G + T+ + + H+LQ I CE+
Sbjct: 67 RVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEM 126
Query: 122 HEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYH 181
EDNST + YDG+ L +T +W A+ A + + ++ + +
Sbjct: 127 QEDNSTEGYWKYGYDGQDHLEFCPDTLDWRA-----AEPRAWPTKLEWERHKIRARQNRA 181
Query: 182 AMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWR 240
+ DC +L++ L+ G VL + VPP+V VT S T+ CRA +YP NIT+ W
Sbjct: 182 YLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVT-TLRCRALNYYPQNITMKWL 240
Query: 241 QDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHST-----HPV 295
+D + + DVLP+G+GTYQ W+ + GEEQR+TC +EH G P
Sbjct: 241 KDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPS 300
Query: 296 PSGKVLVLQSHWQTFHVSAVAAAAIFVIIIF 326
PSG T + ++ A+FV+I+F
Sbjct: 301 PSG----------TLVIGVISGIAVFVVILF 321
>gi|4504415 major histocompatibility complex, class I, G precursor
[Homo sapiens]
Length = 338
Score = 134 bits (336), Expect = 2e-31
Identities = 87/291 (29%), Positives = 143/291 (49%), Gaps = 18/291 (6%)
Query: 6 VFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC- 64
+FLLL+G A + HS+RY +S G + F+ ++D F+R D
Sbjct: 9 LFLLLSGALTLTETWAGS--HSMRYFSAAVSRPGRGEPRFIAMGYVDDTQFVRFDSDSAC 66
Query: 65 -RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIK----DQKEGLHSLQEIRVC 119
R +P+ W E G + W+ ETR+ + + RM L ++ + H+LQ + C
Sbjct: 67 PRMEPRAPWVEQE-GPEYWEEETRNTKAHAQTDRMNLQTLRGYYNQSEASSHTLQWMIGC 125
Query: 120 EIHEDNST-RSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKT 178
++ D R + + YDG+ +L+ N + + WT A A + E A +
Sbjct: 126 DLGSDGRLLRGYEQYAYDGKDYLALNEDLRSWT------AADTAAQISKRKCEAANVAEQ 179
Query: 179 HYHAMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITL 237
+ C++ L RYL++G +L+R PP +VT + T+ C A GFYP I L
Sbjct: 180 RRAYLEGTCVEWLHRYLENGKEMLQRADPPKTHVTHHPVFDYEATLRCWALGFYPAEIIL 239
Query: 238 SWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSG 288
+W++DG + D + + P G+GT+Q W A + GEEQR+TC+++H G
Sbjct: 240 TWQRDGEDQTQDVELV-ETRPAGDGTFQKWAAVVVPSGEEQRYTCHVQHEG 289
>gi|4504417 major histocompatibility complex, class I-related [Homo
sapiens]
Length = 341
Score = 131 bits (330), Expect = 9e-31
Identities = 83/303 (27%), Positives = 144/303 (47%), Gaps = 15/303 (4%)
Query: 26 HSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRE 85
HSLRY +S F++ ++D P D + +P+ W + L W+R
Sbjct: 25 HSLRYFRLGVSDPIHGVPEFISVGYVDSHPITTYDSVTRQKEPRAPWMAENLAPDHWERY 84
Query: 86 TRDLTGNGKDLRMTLAHIKDQ--KEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQ 143
T+ L G + ++ L ++ G H+ Q + CE+ ED ST + YDG+ FL
Sbjct: 85 TQLLRGWQQMFKVELKRLQRHYNHSGSHTYQRMIGCELLEDGSTTGFLQYAYDGQDFLIF 144
Query: 144 NLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGV-VLR 202
N +T W +A ++ + + + + + +C+ L+R+L+ G L+
Sbjct: 145 NKDTLSWLA-----VDNVAHTIKQAWEANQHELLYQKNWLEEECIAWLKRFLEYGKDTLQ 199
Query: 203 RTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNG 262
RT PP+V V R E G + C+A GFYP I ++W ++G + + +GD+LP G+G
Sbjct: 200 RTEPPLVRVNRKETFPGVTALFCKAHGFYPPEIYMTWMKNGEEIVQEID-YGDILPSGDG 258
Query: 263 TYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFV 322
TYQ W + + ++C++EH G H VP +S + AV+ + + V
Sbjct: 259 TYQAWASIELDPQSSNLYSCHVEHCGVHMVLQVPQ------ESETIPLVMKAVSGSIVLV 312
Query: 323 III 325
I++
Sbjct: 313 IVL 315
>gi|21040353 hemochromatosis protein isoform 9 precursor [Homo
sapiens]
Length = 325
Score = 130 bits (328), Expect = 2e-30
Identities = 93/316 (29%), Positives = 149/316 (47%), Gaps = 28/316 (8%)
Query: 20 GAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGN 79
G A P L L +L +Q L ++D Q F+ D + R +P+ W + +
Sbjct: 2 GPRARPALL---LLMLLQTAVLQGRLLPLGYVDDQLFVFYDHESRRVEPRTPWVSSRISS 58
Query: 80 KTWDRETRDLTGNGKDLRM---TLAHIKDQKEGLHSLQEIRVCEIHEDNSTRSSQHFYYD 136
+ W + ++ L G + T+ + + H+LQ I CE+ EDNST + YD
Sbjct: 59 QMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEMQEDNSTEGYWKYGYD 118
Query: 137 GELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLK 196
G+ L +T +W A+ A + + ++ + + + DC +L++ L+
Sbjct: 119 GQDHLEFCPDTLDWRA-----AEPRAWPTKLEWERHKIRARQNRAYLERDCPAQLQQLLE 173
Query: 197 SGV-VLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGD 255
G VL + VPP+V VT S T+ CRA +YP NIT+ W +D + + D
Sbjct: 174 LGRGVLDQQVPPLVKVTHHVTSSVT-TLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKD 232
Query: 256 VLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHST-----HPVPSGKVLVLQSHWQTF 310
VLP+G+GTYQ W+ + GEEQR+TC +EH G P PSG T
Sbjct: 233 VLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSG----------TL 282
Query: 311 HVSAVAAAAIFVIIIF 326
+ ++ A+FV+I+F
Sbjct: 283 VIGVISGIAVFVVILF 298
>gi|21040347 hemochromatosis protein isoform 6 precursor [Homo
sapiens]
Length = 334
Score = 120 bits (301), Expect = 2e-27
Identities = 89/330 (26%), Positives = 143/330 (43%), Gaps = 37/330 (11%)
Query: 5 PVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC 64
P LLL + G HSL Y S S F ++D Q F+ D +
Sbjct: 7 PALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESR 66
Query: 65 RAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRM---TLAHIKDQKEGLHSLQEIRVCEI 121
R +P+ W + ++ W + ++ L G + T+ + + H+LQ I CE+
Sbjct: 67 RVEPRTPWVSSRISSQMWLQLSQSLKGWDHMFTVDFWTIMENHNHSKESHTLQVILGCEM 126
Query: 122 HEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYH 181
EDNST + YDG+ L +T +W A+ A + + ++ + +
Sbjct: 127 QEDNSTEGYWKYGYDGQDHLEFCPDTLDWRA-----AEPRAWPTKLEWERHKIRARQNRA 181
Query: 182 AMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQ 241
+ DC +L++ L+ G R + T+ CRA +YP NIT+ W +
Sbjct: 182 YLERDCPAQLQQLLELG--------------RGVLDQQVTTLRCRALNYYPQNITMKWLK 227
Query: 242 DGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHST-----HPVP 296
D + + DVLP+G+GTYQ W+ + GEEQR+TC +EH G P P
Sbjct: 228 DKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSP 287
Query: 297 SGKVLVLQSHWQTFHVSAVAAAAIFVIIIF 326
SG T + ++ A+FV+I+F
Sbjct: 288 SG----------TLVIGVISGIAVFVVILF 307
>gi|21040349 hemochromatosis protein isoform 7 precursor [Homo
sapiens]
Length = 260
Score = 117 bits (293), Expect = 2e-26
Identities = 74/222 (33%), Positives = 112/222 (50%), Gaps = 22/222 (9%)
Query: 111 HSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLK 170
H+LQ I CE+ EDNST + YDG+ L +T +W A+ A + +
Sbjct: 28 HTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRA-----AEPRAWPTKLEWE 82
Query: 171 EDAMKTKTHYHAMHADCLQELRRYLKSGV-VLRRTVPPMVNVTRSEASEGNITVTCRASG 229
++ + + + DC +L++ L+ G VL + VPP+V VT S T+ CRA
Sbjct: 83 RHKIRARQNRAYLERDCPAQLQQLLELGRGVLDQQVPPLVKVTHHVTSSVT-TLRCRALN 141
Query: 230 FYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGN 289
+YP NIT+ W +D + + DVLP+G+GTYQ W+ + GEEQR+TC +EH G
Sbjct: 142 YYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGL 201
Query: 290 HST-----HPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIF 326
P PSG T + ++ A+FV+I+F
Sbjct: 202 DQPLIVIWEPSPSG----------TLVIGVISGIAVFVVILF 233
>gi|21040351 hemochromatosis protein isoform 8 precursor [Homo
sapiens]
Length = 246
Score = 103 bits (256), Expect = 3e-22
Identities = 66/221 (29%), Positives = 103/221 (46%), Gaps = 34/221 (15%)
Query: 111 HSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLK 170
H+LQ I CE+ EDNST + YDG+ L +T +W A+ A + +
Sbjct: 28 HTLQVILGCEMQEDNSTEGYWKYGYDGQDHLEFCPDTLDWRA-----AEPRAWPTKLEWE 82
Query: 171 EDAMKTKTHYHAMHADCLQELRRYLKSGVVLRRTVPPMVNVTRSEASEGNITVTCRASGF 230
++ + + + DC +L++ L+ G R + T+ CRA +
Sbjct: 83 RHKIRARQNRAYLERDCPAQLQQLLELG--------------RGVLDQQVTTLRCRALNY 128
Query: 231 YPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNH 290
YP NIT+ W +D + + DVLP+G+GTYQ W+ + GEEQR+TC +EH G
Sbjct: 129 YPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYTCQVEHPGLD 188
Query: 291 ST-----HPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIF 326
P PSG T + ++ A+FV+I+F
Sbjct: 189 QPLIVIWEPSPSG----------TLVIGVISGIAVFVVILF 219
>gi|4502337 alpha-2-glycoprotein 1, zinc [Homo sapiens]
Length = 298
Score = 97.8 bits (242), Expect = 1e-20
Identities = 82/288 (28%), Positives = 129/288 (44%), Gaps = 13/288 (4%)
Query: 5 PVFL-LLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQK 63
PV L LL + P P +SL Y T LS F L+ F R + +
Sbjct: 6 PVLLSLLLLLGPAVPQENQDGRYSLTYIYTGLSKHVEDVPAFQALGSLNDLQFFRYNSKD 65
Query: 64 CRAKPQGQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKD---QKEGLHSLQEIRVCE 120
+++P G W + V G + W ++++ TL I + G H LQ CE
Sbjct: 66 RKSQPMGLWRQ-VEGMEDWKQDSQLQKAREDIFMETLKDIVEYYNDSNGSHVLQGRFGCE 124
Query: 121 IHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHY 180
I + S+ + +YYDG+ ++ N E W +P AQ + + + + +
Sbjct: 125 IENNRSSGAFWKYYYDGKDYIEFNKEIPAW-VPFDPAAQI----TKQKWEAEPVYVQRAK 179
Query: 181 HAMHADCLQELRRYLK-SGVVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSW 239
+ +C LR+YLK S +L R PP V VT +A + C A FYP I + W
Sbjct: 180 AYLEEECPATLRKYLKYSKNILDRQDPPSVVVTSHQAPGEKKKLKCLAYDFYPGKIDVHW 239
Query: 240 RQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHS 287
+ G + + GDVL +GNGTYQ+WV + + ++C+++HS
Sbjct: 240 TRAGEVQEPELR--GDVLHNGNGTYQSWVVVAVPPQDTAPYSCHVQHS 285
>gi|21040343 hemochromatosis protein isoform 4 precursor [Homo
sapiens]
Length = 256
Score = 87.8 bits (216), Expect = 1e-17
Identities = 48/127 (37%), Positives = 67/127 (52%), Gaps = 16/127 (12%)
Query: 205 VPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTY 264
VPP+V VT S T+ CRA +YP NIT+ W +D + + DVLP+G+GTY
Sbjct: 114 VPPLVKVTHHVTSSVT-TLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTY 172
Query: 265 QTWVATRICQGEEQRFTCYMEHSGNHST-----HPVPSGKVLVLQSHWQTFHVSAVAAAA 319
Q W+ + GEEQR+TC +EH G P PSG T + ++ A
Sbjct: 173 QGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSG----------TLVIGVISGIA 222
Query: 320 IFVIIIF 326
+FV+I+F
Sbjct: 223 VFVVILF 229
Score = 30.8 bits (68), Expect = 2.1
Identities = 22/87 (25%), Positives = 35/87 (40%)
Query: 5 PVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC 64
P LLL + G HSL Y S S F ++D Q F+ D +
Sbjct: 7 PALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESR 66
Query: 65 RAKPQGQWAEDVLGNKTWDRETRDLTG 91
R +P+ W + ++ W + ++ L G
Sbjct: 67 RVEPRTPWVSSRISSQMWLQLSQSLKG 93
>gi|21040355 hemochromatosis protein isoform 10 precursor [Homo
sapiens]
Length = 168
Score = 87.4 bits (215), Expect = 2e-17
Identities = 48/130 (36%), Positives = 68/130 (52%), Gaps = 16/130 (12%)
Query: 202 RRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGN 261
R +PP+V VT S T+ CRA +YP NIT+ W +D + + DVLP+G+
Sbjct: 23 RLLLPPLVKVTHHVTSSVT-TLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGD 81
Query: 262 GTYQTWVATRICQGEEQRFTCYMEHSGNHST-----HPVPSGKVLVLQSHWQTFHVSAVA 316
GTYQ W+ + GEEQR+TC +EH G P PSG T + ++
Sbjct: 82 GTYQGWITLAVPPGEEQRYTCQVEHPGLDQPLIVIWEPSPSG----------TLVIGVIS 131
Query: 317 AAAIFVIIIF 326
A+FV+I+F
Sbjct: 132 GIAVFVVILF 141
>gi|209862839 Fc fragment of IgG, receptor, transporter, alpha [Homo
sapiens]
Length = 365
Score = 84.0 bits (206), Expect = 2e-16
Identities = 75/280 (26%), Positives = 131/280 (46%), Gaps = 13/280 (4%)
Query: 12 GIFPFAPPGA-AAEPH-SLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQ 69
G+ F PG+ AE H SL Y+LT +S F L Q +L + + A+P
Sbjct: 12 GLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPC 71
Query: 70 GQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRS 129
G W + + W++ET DL K+ A +G ++LQ + CE+ DN++
Sbjct: 72 GAWVWENQVSWYWEKETTDL--RIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVP 129
Query: 130 SQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQ 189
+ F +GE F++ +L+ W + LA++ R ++ A + + + C
Sbjct: 130 TAKFALNGEEFMNFDLKQGTW---GGDWPEALAISQRWQQQDKAANKELTF--LLFSCPH 184
Query: 190 ELRRYLKSG-VVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSH 248
LR +L+ G L PP + + +S G +TC A FYP + L + ++G L+
Sbjct: 185 RLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNG--LAA 242
Query: 249 DTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSG 288
T Q GD P+ +G++ + + G+E + C ++H+G
Sbjct: 243 GTGQ-GDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAG 281
>gi|4758346 Fc fragment of IgG, receptor, transporter, alpha [Homo
sapiens]
Length = 365
Score = 84.0 bits (206), Expect = 2e-16
Identities = 75/280 (26%), Positives = 131/280 (46%), Gaps = 13/280 (4%)
Query: 12 GIFPFAPPGA-AAEPH-SLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQ 69
G+ F PG+ AE H SL Y+LT +S F L Q +L + + A+P
Sbjct: 12 GLLLFLLPGSLGAESHLSLLYHLTAVSSPAPGTPAFWVSGWLGPQQYLSYNSLRGEAEPC 71
Query: 70 GQWAEDVLGNKTWDRETRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCEIHEDNSTRS 129
G W + + W++ET DL K+ A +G ++LQ + CE+ DN++
Sbjct: 72 GAWVWENQVSWYWEKETTDL--RIKEKLFLEAFKALGGKGPYTLQGLLGCELGPDNTSVP 129
Query: 130 SQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQ 189
+ F +GE F++ +L+ W + LA++ R ++ A + + + C
Sbjct: 130 TAKFALNGEEFMNFDLKQGTW---GGDWPEALAISQRWQQQDKAANKELTF--LLFSCPH 184
Query: 190 ELRRYLKSG-VVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNITLSWRQDGVSLSH 248
LR +L+ G L PP + + +S G +TC A FYP + L + ++G L+
Sbjct: 185 RLREHLERGRGNLEWKEPPSMRLKARPSSPGFSVLTCSAFSFYPPELQLRFLRNG--LAA 242
Query: 249 DTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSG 288
T Q GD P+ +G++ + + G+E + C ++H+G
Sbjct: 243 GTGQ-GDFGPNSDGSFHASSSLTVKSGDEHHYCCIVQHAG 281
>gi|21040341 hemochromatosis protein isoform 3 precursor [Homo
sapiens]
Length = 242
Score = 80.5 bits (197), Expect = 2e-15
Identities = 41/110 (37%), Positives = 59/110 (53%), Gaps = 15/110 (13%)
Query: 222 TVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFT 281
T+ CRA +YP NIT+ W +D + + DVLP+G+GTYQ W+ + GEEQR+T
Sbjct: 116 TLRCRALNYYPQNITMKWLKDKQPMDAKEFEPKDVLPNGDGTYQGWITLAVPPGEEQRYT 175
Query: 282 CYMEHSGNHST-----HPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIF 326
C +EH G P PSG T + ++ A+FV+I+F
Sbjct: 176 CQVEHPGLDQPLIVIWEPSPSG----------TLVIGVISGIAVFVVILF 215
Score = 30.8 bits (68), Expect = 2.1
Identities = 22/87 (25%), Positives = 35/87 (40%)
Query: 5 PVFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC 64
P LLL + G HSL Y S S F ++D Q F+ D +
Sbjct: 7 PALLLLMLLQTAVLQGRLLRSHSLHYLFMGASEQDLGLSLFEALGYVDDQLFVFYDHESR 66
Query: 65 RAKPQGQWAEDVLGNKTWDRETRDLTG 91
R +P+ W + ++ W + ++ L G
Sbjct: 67 RVEPRTPWVSSRISSQMWLQLSQSLKG 93
>gi|149158700 major histocompatibility complex, class I, F isoform 3
precursor [Homo sapiens]
Length = 254
Score = 70.1 bits (170), Expect = 3e-12
Identities = 58/202 (28%), Positives = 94/202 (46%), Gaps = 20/202 (9%)
Query: 6 VFLLLAGIFPFAPPGAAAEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKC- 64
+ LLL+G A + HSLRY T +S G + ++ ++D FLR D
Sbjct: 6 LLLLLSGALALTDTWAGS--HSLRYFSTAVSRPGRGEPRYIAVEYVDDTQFLRFDSDAAI 63
Query: 65 -RAKPQGQWAEDVLGNKTWDRETRDLTGNGKD----LRMTLAHIKDQKEGLHSLQEIRVC 119
R +P+ W E G + W+ T N + LR L + G H+LQ + C
Sbjct: 64 PRMEPREPWVEQE-GPQYWEWTTGYAKANAQTDRVALRNLLRRYNQSEAGSHTLQGMNGC 122
Query: 120 EIHEDNSTRSSQHFY-YDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNF--LKEDAMKT 176
++ D H + YDG+ ++S N + + WT A T+A + F +E A +
Sbjct: 123 DMGPDGRLLRGYHQHAYDGKDYISLNEDLRSWT-----AADTVAQITQRFYEAEEYAEEF 177
Query: 177 KTHYHAMHADCLQELRRYLKSG 198
+T+ + +CL+ LRRYL++G
Sbjct: 178 RTY---LEGECLELLRRYLENG 196
>gi|4502649 CD1D antigen precursor [Homo sapiens]
Length = 335
Score = 65.5 bits (158), Expect = 8e-11
Identities = 69/285 (24%), Positives = 121/285 (42%), Gaps = 45/285 (15%)
Query: 72 WAEDVLGNKTWDRE-----------TRDLTGNGKDLRMTLAHIKDQKEGLHSLQEIRVCE 120
W++ ++ W+ TRD+ K LR++ LQ CE
Sbjct: 71 WSQGTFSDQQWETLQHIFRVYRSSFTRDVKEFAKMLRLSYPL---------ELQVSAGCE 121
Query: 121 IHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQT-LAMNVRNFLKEDAMKTKTH 179
+H N++ + H + G+ LS + W Q + LA+ V N +D +T
Sbjct: 122 VHPGNASNNFFHVAFQGKDILS--FQGTSWEPTQEAPLWVNLAIQVLN---QDKWTRETV 176
Query: 180 YHAMHADCLQELRRYLKSGVV-LRRTVPPMVNVTRSEA-SEGNITVTCRASGFYPWNITL 237
++ C Q + L+SG L++ V P ++R + G + + C SGFYP + +
Sbjct: 177 QWLLNGTCPQFVSGLLESGKSELKKQVKPKAWLSRGPSPGPGRLLLVCHVSGFYPKPVWV 236
Query: 238 SWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPS 297
W + G TQ GD+LP+ + T+ + GE +C ++HS
Sbjct: 237 KWMR-GEQEQQGTQP-GDILPNADETWYLRATLDVVAGEAAGLSCRVKHSS-------LE 287
Query: 298 GKVLVLQSHWQTFHVS------AVAAAAIFVIIIFYVRCCKKKTS 336
G+ +VL +W + S AV A +F++I+ + K++TS
Sbjct: 288 GQDIVL--YWGGSYTSMGLIALAVLACLLFLLIVGFTSRFKRQTS 330
>gi|110618227 CD1C antigen precursor [Homo sapiens]
Length = 333
Score = 58.5 bits (140), Expect = 1e-08
Identities = 55/224 (24%), Positives = 92/224 (41%), Gaps = 21/224 (9%)
Query: 119 CEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMK-TK 177
CE+H S ++G LS + W S +LA +V + L T+
Sbjct: 120 CELHSGKSPEGFFQVAFNGLDLLS--FQNTTWV--PSPGCGSLAQSVCHLLNHQYEGVTE 175
Query: 178 THYHAMHADCLQELRRYLKSG--VVLRRTVPPMVNVTRSEASEGNITVTCRASGFYPWNI 235
T Y+ + + C + L L +G V R+ P +R G + + C ASGFYP +
Sbjct: 176 TVYNLIRSTCPRFLLGLLDAGKMYVHRQVRPEAWLSSRPSLGSGQLLLVCHASGFYPKPV 235
Query: 236 TLSW---RQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRFTCYMEHSGNHST 292
++W Q+ + H GD+LP+ +GT+ V + E +C + HS
Sbjct: 236 WVTWMRNEQEQLGTKH-----GDILPNADGTWYLQVILEVASEEPAGLSCRVRHSS---- 286
Query: 293 HPVPSGKVLVLQSHWQTFHVSAVAAAAIFVIIIFYVRCCKKKTS 336
+ +++ H + + A+ VI+I V KK S
Sbjct: 287 --LGGQDIILYWGHHFSMNWIALVVIVPLVILIVLVLWFKKHCS 328
>gi|110618224 CD1A antigen precursor [Homo sapiens]
Length = 327
Score = 55.8 bits (133), Expect = 6e-08
Identities = 57/224 (25%), Positives = 99/224 (44%), Gaps = 27/224 (12%)
Query: 111 HSLQ-----EIRV---CEIHEDNSTRSSQHFYYDGELFLSQNLETKEWTMPQSSRAQTLA 162
H LQ EI+V CE+H + S Y G F+S + W +P A +A
Sbjct: 103 HELQFEYPFEIQVTGGCELHSGKVSGSFLQLAYQGSDFVS--FQNNSW-LPYPV-AGNMA 158
Query: 163 MNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVV-LRRTVPPMVNVTRSEA-SEGN 220
+ L ++ + ++ + C + + L +G L+R V P ++ + G+
Sbjct: 159 KHFCKVLNQNQHENDITHNLLSDTCPRFILGLLDAGKAHLQRQVKPEAWLSHGPSPGPGH 218
Query: 221 ITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRICQGEEQRF 280
+ + C SGFYP + + W + G TQ+ GD+LP +GT+ + GE
Sbjct: 219 LQLVCHVSGFYPKPVWVMWMR-GEQEQQGTQR-GDILPSADGTWYLRATLEVAAGEAADL 276
Query: 281 TCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAAAIFVII 324
+C ++HS G+ +VL +W+ H S+V + VI+
Sbjct: 277 SCRVKHSS-------LEGQDIVL--YWE--HHSSVGFIILAVIV 309
>gi|21040249 retinoic acid early transcript 1E [Homo sapiens]
Length = 263
Score = 55.5 bits (132), Expect = 8e-08
Identities = 48/172 (27%), Positives = 68/172 (39%), Gaps = 7/172 (4%)
Query: 26 HSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTWDRE 85
HSL +N T+ S Q +V L+ FL+ + KP G + V TW
Sbjct: 31 HSLCFNFTIKSLSRPGQPWCEAQVFLNKNLFLQYNSDNNMVKPLGLLGKKVYATSTWGEL 90
Query: 86 TRDLTGNGKDLRMTLAHIKDQ--KEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGELFLSQ 143
T+ L G+DLRM L IK Q +LQ C+ + T +S F +GE L
Sbjct: 91 TQTLGEVGRDLRMLLCDIKPQIKTSDPSTLQVEMFCQREAERCTGASWQFATNGEKSLLF 150
Query: 144 NLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYL 195
+ WT+ A ++ K+D K DC LR +L
Sbjct: 151 DAMNMTWTVINHE-----ASKIKETWKKDRGLEKYFRKLSKGDCDHWLREFL 197
>gi|4504399 major histocompatibility complex, class II, DM beta
precursor [Homo sapiens]
Length = 263
Score = 54.3 bits (129), Expect = 2e-07
Identities = 50/188 (26%), Positives = 77/188 (40%), Gaps = 32/188 (17%)
Query: 141 LSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGVV 200
LSQ+L K+ TL +RN L+ A T+ + G +
Sbjct: 76 LSQHLNQKD----------TLMQRLRNGLQNCATHTQPFW-----------------GSL 108
Query: 201 LRRTVPPMVNVTRSEA--SEGNITVTCRASGFYPWNITLSWRQDGVSLSHDTQQWGDVLP 258
RT PP V V ++ + + + C GFYP +T++WR++G + + P
Sbjct: 109 TNRTRPPSVQVAKTTPFNTREPVMLACYVWGFYPAEVTITWRKNGKLVMPHSSAHKTAQP 168
Query: 259 DGNGTYQTWVATRICQGEEQRFTCYMEHSGNHSTHPVPSGKVLVLQSHWQTFHVSAVAAA 318
+G+ TYQT + +TC +EH G + P+ L S QT VS A
Sbjct: 169 NGDWTYQTLSHLALTPSYGDTYTCVVEHIG--APEPILRDWTPGL-SPMQTLKVSVSAVT 225
Query: 319 AIFVIIIF 326
+IIF
Sbjct: 226 LGLGLIIF 233
>gi|13375656 UL16 binding protein 3 [Homo sapiens]
Length = 244
Score = 53.9 bits (128), Expect = 2e-07
Identities = 49/189 (25%), Positives = 76/189 (40%), Gaps = 9/189 (4%)
Query: 23 AEPHSLRYNLTVLSWDGSVQSGFLTEVHLDGQPFLRCDRQKCRAKPQGQWAEDVLGNKTW 82
A+ HSL YN T++ Q + +D + FL D + G E + W
Sbjct: 29 ADAHSLWYNFTIIHLPRHGQQWCEVQSQVDQKNFLSYDCGSDKVLSMGHLEEQLYATDAW 88
Query: 83 DRETRDLTGNGKDLRMTLA--HIKD-QKEGLHSLQEIRVCEIHEDNSTRSSQHFYYDGEL 139
++ L G+ LR+ LA ++D G +LQ CE D R S F +DG
Sbjct: 89 GKQLEMLREVGQRLRLELADTELEDFTPSGPLTLQVRMSCECEADGYIRGSWQFSFDGRK 148
Query: 140 FLSQNLETKEWTMPQSSRAQTLAMNVRNFLKEDAMKTKTHYHAMHADCLQELRRYLKSGV 199
FL + ++WT+ + A ++ ++D+ T DC LR +L
Sbjct: 149 FLLFDSNNRKWTVVHAG-----ARRMKEKWEKDSGLTTFFKMVSMRDCKSWLRDFLMHRK 203
Query: 200 V-LRRTVPP 207
L T PP
Sbjct: 204 KRLEPTAPP 212
>gi|144953876 signal-regulatory protein beta 1 isoform 1 precursor
[Homo sapiens]
Length = 398
Score = 50.8 bits (120), Expect = 2e-06
Identities = 39/158 (24%), Positives = 67/158 (42%), Gaps = 18/158 (11%)
Query: 183 MHADCLQELRRYLKSGVVLRRT--------VPPMVNVTRSEA-SEGNITVTCRASGFYPW 233
+H+ + E+ G LR T VPP + VT+ +E VTC+ S FYP
Sbjct: 221 VHSQVICEIAHITLQGDPLRGTANLSEAIRVPPTLEVTQQPMRAENQANVTCQVSNFYPR 280
Query: 234 NITLSWRQDGVSLSHDTQQWGDVLPDGNGTYQTWVATRIC-QGEEQRFTCYMEHSGNHST 292
+ L+W ++G +T DG + +W+ C ++ TC +EH G +
Sbjct: 281 GLQLTWLENGNVSRTETASTLIENKDGTYNWMSWLLVNTCAHRDDVVLTCQVEHDGQQA- 339
Query: 293 HPVPSGKVLVLQSHWQTF-----HVSAVAAAAIFVIII 325
V L + +H + H +A+A A ++ +
Sbjct: 340 --VSKSYALEISAHQKEHGSDITHEAALAPTAPLLVAL 375
Score = 31.2 bits (69), Expect = 1.6
Identities = 13/30 (43%), Positives = 19/30 (63%)
Query: 218 EGNITVTCRASGFYPWNITLSWRQDGVSLS 247
E ++ TC + GF P +ITL W ++G LS
Sbjct: 162 EHTVSFTCESHGFSPRDITLKWFKNGNELS 191
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,750,207
Number of Sequences: 37866
Number of extensions: 717373
Number of successful extensions: 1816
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 44
Number of HSP's successfully gapped in prelim test: 59
Number of HSP's that attempted gapping in prelim test: 1653
Number of HSP's gapped (non-prelim): 119
length of query: 383
length of database: 18,247,518
effective HSP length: 104
effective length of query: 279
effective length of database: 14,309,454
effective search space: 3992337666
effective search space used: 3992337666
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.