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Search of human proteins with 45243561
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45243561 delta-like 3 protein isoform 2 precursor [Homo
sapiens]
(587 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens] 1269 0.0
gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens] 1268 0.0
gi|110735443 delta-like 1 [Homo sapiens] 350 3e-96
gi|9506545 delta-like 4 protein precursor [Homo sapiens] 324 2e-88
gi|21704279 jagged 2 isoform b precursor [Homo sapiens] 224 1e-58
gi|21704277 jagged 2 isoform a precursor [Homo sapiens] 219 7e-57
gi|4557679 jagged 1 precursor [Homo sapiens] 213 4e-55
gi|134244285 Notch homolog 3 [Homo sapiens] 194 2e-49
gi|24041035 notch 2 preproprotein [Homo sapiens] 193 3e-49
gi|148833508 notch1 preproprotein [Homo sapiens] 184 2e-46
gi|55770876 notch4 preproprotein [Homo sapiens] 184 2e-46
gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens] 177 2e-44
gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens] 177 2e-44
gi|148886654 polydom [Homo sapiens] 174 3e-43
gi|41327708 crumbs homolog 1 precursor [Homo sapiens] 173 5e-43
gi|112420992 crumbs homolog 2 [Homo sapiens] 170 4e-42
gi|122937283 6720455I24Rik homolog [Homo sapiens] 160 2e-39
gi|74136023 delta-like 1 homolog [Homo sapiens] 159 9e-39
gi|188528675 slit homolog 1 [Homo sapiens] 159 9e-39
gi|11321571 slit homolog 3 [Homo sapiens] 157 3e-38
gi|116235485 delta-notch-like EGF repeat-containing transmembran... 155 1e-37
gi|224451128 eyes shut homolog isoform 1 [Homo sapiens] 154 3e-37
gi|4759146 slit homolog 2 [Homo sapiens] 149 7e-36
gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens] 131 2e-30
gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens] 128 1e-29
gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens] 123 4e-28
gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens] 123 5e-28
gi|14192943 multiple EGF-like-domains 10 [Homo sapiens] 118 2e-26
gi|122937343 platelet endothelial aggregation receptor 1 [Homo s... 114 2e-25
gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens] 110 3e-24
>gi|45243561 delta-like 3 protein isoform 2 precursor [Homo sapiens]
Length = 587
Score = 1269 bits (3285), Expect = 0.0
Identities = 587/587 (100%), Positives = 587/587 (100%)
Query: 1 MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFF 60
MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFF
Sbjct: 1 MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFF 60
Query: 61 RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTF 120
RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTF
Sbjct: 61 RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTF 120
Query: 121 SFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEP 180
SFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEP
Sbjct: 121 SFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEP 180
Query: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCL 240
PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCL
Sbjct: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCL 240
Query: 241 EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTC 300
EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTC
Sbjct: 241 EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTC 300
Query: 301 PRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQ 360
PRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQ
Sbjct: 301 PRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQ 360
Query: 361 PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALG 420
PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALG
Sbjct: 361 PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALG 420
Query: 421 FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAP 480
FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAP
Sbjct: 421 FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAP 480
Query: 481 PGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540
PGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHAL
Sbjct: 481 PGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540
Query: 541 PDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYAREA 587
PDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYAREA
Sbjct: 541 PDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYAREA 587
>gi|8393264 delta-like 3 protein isoform 1 precursor [Homo sapiens]
Length = 618
Score = 1268 bits (3281), Expect = 0.0
Identities = 586/586 (100%), Positives = 586/586 (100%)
Query: 1 MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFF 60
MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFF
Sbjct: 1 MVSPRMSGLLSQTVILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSARLPCRLFF 60
Query: 61 RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTF 120
RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTF
Sbjct: 61 RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDGLLQVPFRDAWPGTF 120
Query: 121 SFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEP 180
SFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEP
Sbjct: 121 SFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEP 180
Query: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCL 240
PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCL
Sbjct: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCL 240
Query: 241 EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTC 300
EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTC
Sbjct: 241 EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTC 300
Query: 301 PRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQ 360
PRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQ
Sbjct: 301 PRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQ 360
Query: 361 PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALG 420
PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALG
Sbjct: 361 PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALG 420
Query: 421 FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAP 480
FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAP
Sbjct: 421 FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAP 480
Query: 481 PGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540
PGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHAL
Sbjct: 481 PGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540
Query: 541 PDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYARE 586
PDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYARE
Sbjct: 541 PDALNNLRTQEGSGDGPSSSVDWNRPEDVDPQGIYVISAPSIYARE 586
>gi|110735443 delta-like 1 [Homo sapiens]
Length = 723
Score = 350 bits (897), Expect = 3e-96
Identities = 209/584 (35%), Positives = 275/584 (47%), Gaps = 93/584 (15%)
Query: 10 LSQTVILALIFLPQTRPAGVFELQIHSFGPGPG---------PGAPRSPCSARLPCRLFF 60
L+ V+ AL L Q +GVFEL++ F G GA PC+ CR FF
Sbjct: 7 LALAVLSAL--LCQVWSSGVFELKLQEFVNKKGLLGNRNCCRGGAGPPPCA----CRTFF 60
Query: 61 RVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPDG---------LLQVP 111
RVCLK + + E PC G+A++ P LPDG ++ P
Sbjct: 61 RVCLKHYQASVSPEPPCTYGSAVT---------PVLGVDSFSLPDGGGADSAFSNPIRFP 111
Query: 112 FRDAWPGTFSFIIETWREELGDQIGGP-AWSLLARVAGRRRLAAGGPWARDIQRAGAWEL 170
F WPGTFS IIE + D + L++R+A +R L G W++D+ +G +L
Sbjct: 112 FGFTWPGTFSLIIEALHTDSPDDLATENPERLISRLATQRHLTVGEEWSQDLHSSGRTDL 171
Query: 171 RFSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECEAPLVCRAGC 224
++SYR C+ G C+ CRPR CG G + C P C P +C GC
Sbjct: 172 KYSYRFVCDEHYYGEGCSVFCRPRDDAFGHFTCGERGEKVCNPGWKGPYCTEP-ICLPGC 230
Query: 225 SPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCL-------------------------- 258
+HGFC++PGEC+C GW G C + CL
Sbjct: 231 DEQHGFCDKPGECKCRVGWQGRYCDECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLN 290
Query: 259 --------------SPRGPSSATTGCLVPGPGP--------CDGNPCANGGSCSETPRSF 296
+ G S T C G CD +PC NGGSC++ S+
Sbjct: 291 YCTHHKPCKNGATCTNTGQGSYTCSCRPGYTGATCELGIDECDPSPCKNGGSCTDLENSY 350
Query: 297 ECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDR 356
CTCP GFYG CE+S +TCADGPCFNGG C PD Y C CP G+ G NCEK++D
Sbjct: 351 SCTCPPGFYGKICELSAMTCADGPCFNGGRC--SDSPDGGYSCRCPVGYSGFNCEKKIDY 408
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCS 416
CS PC NG C+DLG A CRC+AGF+G C+ ++DDCA CANGGTC +G C+
Sbjct: 409 CSSSPCSNGAKCVDLGDAYLCRCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCT 468
Query: 417 CALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEF--PVHPDGAS 474
C G+ GR+C C PC +G C+ VC CA GY G C+F P P G +
Sbjct: 469 CPPGYTGRNCSAPVSRCEHAPCHNGATCHERGHRYVCECARGYGGPNCQFLLPELPPGPA 528
Query: 475 ALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRR 518
+ G P ++ A +LV + G A ++V VR R
Sbjct: 529 VVDLTEKLEGQGGPFPWVAVCAGVILVLMLLLGCAAVVVCVRLR 572
>gi|9506545 delta-like 4 protein precursor [Homo sapiens]
Length = 685
Score = 324 bits (830), Expect = 2e-88
Identities = 213/582 (36%), Positives = 268/582 (46%), Gaps = 98/582 (16%)
Query: 15 ILALIFLPQTRPAG--VFELQIHSFGPGPGPGAPRSPCSARLPCRLFFRVCLKPGLSEEA 72
+L L+ L Q R AG VF+LQ+ F G A PC CR FFRVCLK
Sbjct: 13 LLLLVALWQQRAAGSGVFQLQLQEFINERGVLASGRPCEPG--CRTFFRVCLKH-FQAVV 69
Query: 73 AESPCALGAALSARGPVYTEQPGAPAPDLPLPD-GLLQVPFRDAWPGTFSFIIETWREEL 131
+ PC G + PV A D LQ+PF WPGTFS IIE W
Sbjct: 70 SPGPCTFGTVST---PVLGTNSFAVRDDSSGGGRNPLQLPFNFTWPGTFSLIIEAWHAP- 125
Query: 132 GDQIGG---PAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACT 188
GD + P +L++++A + LA G W D Q + LR+SYR C G C+
Sbjct: 126 GDDLRPEALPPDALISKIAIQGSLAVGQNWLLDEQTSTLTRLRYSYRVICSDNYYGDNCS 185
Query: 189 RLCRPRS---APSRCGP-GLRPCAP--LEDECEAPLVCRAGCSPEHGFCEQPGECRCLEG 242
RLC+ R+ C P G C P + C+ P +C +GC ++G+C +P EC C G
Sbjct: 186 RLCKKRNDHFGHYVCQPDGNLSCLPGWTGEYCQQP-ICLSGCHEQNGYCSKPAECLCRPG 244
Query: 243 WTGPLCTVPVSTSSC----------------------------------------LSPRG 262
W G LC + + C S G
Sbjct: 245 WQGRLCNECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSG 304
Query: 263 PSSATTGCLVPGPG--------PCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGV 314
S T C G CD NPC NGGSC + + C CP G+YGL CE S +
Sbjct: 305 QRSYTCTCRPGYTGVDCELELSECDSNPCRNGGSCKDQEDGYHCLCPPGYYGLHCEHSTL 364
Query: 315 TCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHA 374
+CAD PCFNGG C + + Y C CPP F GSNCEK+VDRC+ PC NGG CL+ G +
Sbjct: 365 SCADSPCFNGGSC-RERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGPS 423
Query: 375 LRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERA--DP 432
CRCR GF G CE + DCA CA+GGTC + C+C GF GR C R D
Sbjct: 424 RMCRCRPGFTGTYCELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSIDA 483
Query: 433 CAARPCAHGGRCYAHFS--GLVCACAPGYMGARCEFPVHPDGASALPAAPPGLRPGDPQR 490
CA+ PC + CY S VC C G++G+RCEFPV GL P P
Sbjct: 484 CASSPCFNRATCYTDLSTDTFVCNCPYGFVGSRCEFPV-------------GLPPSFP-- 528
Query: 491 YLLPPALG-----LLVAAGVAGAALLLVHVRRRGHSQDAGSR 527
+ +LG LLV G+ A+ + +RR D GSR
Sbjct: 529 -WVAVSLGVGLAVLLVLLGMVAVAVRQLRLRR----PDDGSR 565
>gi|21704279 jagged 2 isoform b precursor [Homo sapiens]
Length = 1200
Score = 224 bits (572), Expect = 1e-58
Identities = 155/533 (29%), Positives = 207/533 (38%), Gaps = 83/533 (15%)
Query: 14 VILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSA-----------RLPCRLFFRV 62
++L +++ RP G FELQ+ + G + C C + RV
Sbjct: 14 LLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRV 73
Query: 63 CLKPGLSEEAAESPCALG--AALSARGPVYTEQPGAPAPDLPLP---------DGLLQVP 111
CLK ++ PC+ G A G + P A D GL+ +P
Sbjct: 74 CLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIP 133
Query: 112 FRDAWPGTFSFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELR 171
F+ AWP +F+ I+E W + + L+ RV+ + W L
Sbjct: 134 FQFAWPRSFTLIVEAW--DWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLE 191
Query: 172 FSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECEAPLVCRAGCS 225
R RC+ C + CRPR+ C G + C + EC+ VC+ GC+
Sbjct: 192 LQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA-VCKQGCN 250
Query: 226 PEHGFCEQPGECRCLEGWTGPLCTVPVST-----SSCLSP-------------------- 260
HG C PGECRC GW G C V SC+ P
Sbjct: 251 LLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNY 310
Query: 261 ---RGPSSATTGCLVPGPGP--------------------CDGNPCANGGSCSETPRSFE 297
P + C+ P C NPCANGGSC E P FE
Sbjct: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFE 370
Query: 298 CTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRC 357
C CP G+ G C + CA PC GG CV D + C CP + G+ C+ V+ C
Sbjct: 371 CHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVD---GFECICPEQWVGATCQLDVNDC 427
Query: 358 SLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSC 417
Q C++GG C DL + +C C GF G CE + D+CA C +GG C + C C
Sbjct: 428 RGQ-CQHGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHC 486
Query: 418 ALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHP 470
GF G C D C PC +G RCY CAC + G C P P
Sbjct: 487 PQGFSGPLCEVDVDLCEPSPCRNGARCYNLEGDYYCACPDDFGGKNCSVPREP 539
Score = 173 bits (439), Expect = 3e-43
Identities = 103/307 (33%), Positives = 128/307 (41%), Gaps = 42/307 (13%)
Query: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG---E 236
P G AC + S GPG+ P +G HG C QPG
Sbjct: 539 PCPGGACRVI---DGCGSDAGPGM------------PGTAASGVCGPHGRCVSQPGGNFS 583
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATT-------GCLVPG----------PGPCD 279
C C G+TG C + CL + T C P P C
Sbjct: 584 CICDSGFTGTYCHENID--DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 641
Query: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
+PC + G C + F C C G+ G C C C NGG C D + C
Sbjct: 642 PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD---TFRC 698
Query: 340 HCPPGFQGSNCE-KRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
CPPG++GS C + C PC NGG C+ G + C CR G+ G C H+ +DC
Sbjct: 699 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL 758
Query: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
C NGG CV+G RC CA GF G DCR D C + PCA+G C +G C+C PG
Sbjct: 759 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 818
Query: 459 YMGARCE 465
G RC+
Sbjct: 819 RAGPRCQ 825
Score = 146 bits (368), Expect = 6e-35
Identities = 83/245 (33%), Positives = 110/245 (44%), Gaps = 30/245 (12%)
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPG-----------------PGPCD 279
C C GW G LC + + CL S LV CD
Sbjct: 622 CFCPSGWEGELCDT--NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 679
Query: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVS-GVTCADGPCFNGGLCVGGADPDSAYI 338
C+NGG+C ++ +F C CP G+ G C V+ +C PC NGG CVG +++
Sbjct: 680 AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG---ASFS 736
Query: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
C C G++G C + C+ PC NGG+C+D + RC C GFAGP C ++D+C
Sbjct: 737 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 796
Query: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV-----C 453
CA G TCV+ +RCSC G G C+E R C G + H S V C
Sbjct: 797 PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSC 854
Query: 454 ACAPG 458
C G
Sbjct: 855 RCLDG 859
Score = 122 bits (307), Expect = 7e-28
Identities = 85/278 (30%), Positives = 109/278 (39%), Gaps = 69/278 (24%)
Query: 205 RPCAPLEDECEAPLVCRAGCSPEHGFCEQPGE---CRCLEGWTGPLCTVPVSTSSCLSPR 261
+ C E +C+A C G G C G+ C C GW G C V SSCL
Sbjct: 669 KTCHSREFQCDA-YTCSNG-----GTCYDSGDTFRCACPPGWKGSTCAV-AKNSSCLP-- 719
Query: 262 GPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPC 321
NPC NGG+C + SF C C G+ G C + C PC
Sbjct: 720 -------------------NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 760
Query: 322 FNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRA 381
+NGG+CV G + + C C PGF G +C +D C PC G C+D + RC C
Sbjct: 761 YNGGICVDGVN---WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPP 817
Query: 382 GFAGPRCEHDLDDCAGRACANGGTCVEGGGA-----HRCSCALGFG-------------- 422
G AGPRC+ + GR+C + GT G + + C C G
Sbjct: 818 GRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLL 875
Query: 423 -------------GRDCRERAD-PCAARPCAHGGRCYA 446
G+ C E+A C PC G C A
Sbjct: 876 AGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGA 913
Score = 36.6 bits (83), Expect = 0.066
Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 23/147 (15%)
Query: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHG--F 230
+Y A C G C+ P R GP + C + G HG +
Sbjct: 799 AYGATCVDEINGYRCS------CPPGRAGPRCQEVIGFGRSCWS-----RGTPFPHGSSW 847
Query: 231 CEQPGECRCLEG-------WTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPC 283
E CRCL+G W G + LS + P CL PG C PC
Sbjct: 848 VEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQR--CLEKAPGQCLRPPC 905
Query: 284 ANGGSC-SETPRSFECTCPRGFYGLRC 309
G C +E P S C G C
Sbjct: 906 EAWGECGAEEPPSTPCLPRSGHLDNNC 932
>gi|21704277 jagged 2 isoform a precursor [Homo sapiens]
Length = 1238
Score = 219 bits (557), Expect = 7e-57
Identities = 159/568 (27%), Positives = 210/568 (36%), Gaps = 115/568 (20%)
Query: 14 VILALIFLPQTRPAGVFELQIHSFGPGPGPGAPRSPCSA-----------RLPCRLFFRV 62
++L +++ RP G FELQ+ + G + C C + RV
Sbjct: 14 LLLLALWVQAARPMGYFELQLSALRNVNGELLSGACCDGDGRTTRAGGCGHDECDTYVRV 73
Query: 63 CLKPGLSEEAAESPCALG--AALSARGPVYTEQPGAPAPDLPLP---------DGLLQVP 111
CLK ++ PC+ G A G + P A D GL+ +P
Sbjct: 74 CLKEYQAKVTPTGPCSYGHGATPVLGGNSFYLPPAGAAGDRARARARAGGDQDPGLVVIP 133
Query: 112 FRDAWPGTFSFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELR 171
F+ AWP +F+ I+E W + + L+ RV+ + W L
Sbjct: 134 FQFAWPRSFTLIVEAW--DWDNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLE 191
Query: 172 FSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECEAPLVCRAGCS 225
R RC+ C + CRPR+ C G + C + EC+ VC+ GC+
Sbjct: 192 LQIRVRCDENYYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEA-VCKQGCN 250
Query: 226 PEHGFCEQPGECRCLEGWTGPLCTVPVST-----SSCLSP-------------------- 260
HG C PGECRC GW G C V SC+ P
Sbjct: 251 LLHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNY 310
Query: 261 ---RGPSSATTGCLVPGPGP--------------------CDGNPCANGGSCSETPRSFE 297
P + C+ P C NPCANGGSC E P FE
Sbjct: 311 CGSHHPCTNGGTCINAEPDQYRCTCPDGYSGRNCEKAEHACTSNPCANGGSCHEVPSGFE 370
Query: 298 CTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD------PDS---------------- 335
C CP G+ G C + CA PC GG CV D P+
Sbjct: 371 CHCPSGWSGPTCALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGK 430
Query: 336 -------------AYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAG 382
Y C C PG++G NC V+ C Q C++GG C DL + +C C G
Sbjct: 431 PCLNAFSCKNLIGGYYCDCIPGWKGINCHINVNDCRGQ-CQHGGTCKDLVNGYQCVCPRG 489
Query: 383 FAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGG 442
F G CE + D+CA C +GG C + C C GF G C D C PC +G
Sbjct: 490 FGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSGPLCEVDVDLCEPSPCRNGA 549
Query: 443 RCYAHFSGLVCACAPGYMGARCEFPVHP 470
RCY CAC + G C P P
Sbjct: 550 RCYNLEGDYYCACPDDFGGKNCSVPREP 577
Score = 173 bits (439), Expect = 3e-43
Identities = 103/307 (33%), Positives = 128/307 (41%), Gaps = 42/307 (13%)
Query: 181 PAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG---E 236
P G AC + S GPG+ P +G HG C QPG
Sbjct: 577 PCPGGACRVI---DGCGSDAGPGM------------PGTAASGVCGPHGRCVSQPGGNFS 621
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATT-------GCLVPG----------PGPCD 279
C C G+TG C + CL + T C P P C
Sbjct: 622 CICDSGFTGTYCHENID--DCLGQPCRNGGTCIDEVDAFRCFCPSGWEGELCDTNPNDCL 679
Query: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYIC 339
+PC + G C + F C C G+ G C C C NGG C D + C
Sbjct: 680 PDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYTCSNGGTCYDSGD---TFRC 736
Query: 340 HCPPGFQGSNCE-KRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
CPPG++GS C + C PC NGG C+ G + C CR G+ G C H+ +DC
Sbjct: 737 ACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPL 796
Query: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
C NGG CV+G RC CA GF G DCR D C + PCA+G C +G C+C PG
Sbjct: 797 PCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPPG 856
Query: 459 YMGARCE 465
G RC+
Sbjct: 857 RAGPRCQ 863
Score = 146 bits (368), Expect = 6e-35
Identities = 83/245 (33%), Positives = 110/245 (44%), Gaps = 30/245 (12%)
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPG-----------------PGPCD 279
C C GW G LC + + CL S LV CD
Sbjct: 660 CFCPSGWEGELCDT--NPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCD 717
Query: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVS-GVTCADGPCFNGGLCVGGADPDSAYI 338
C+NGG+C ++ +F C CP G+ G C V+ +C PC NGG CVG +++
Sbjct: 718 AYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNPCVNGGTCVGSG---ASFS 774
Query: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
C C G++G C + C+ PC NGG+C+D + RC C GFAGP C ++D+C
Sbjct: 775 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS 834
Query: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV-----C 453
CA G TCV+ +RCSC G G C+E R C G + H S V C
Sbjct: 835 PCAYGATCVDEINGYRCSCPPGRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSC 892
Query: 454 ACAPG 458
C G
Sbjct: 893 RCLDG 897
Score = 122 bits (307), Expect = 7e-28
Identities = 85/278 (30%), Positives = 109/278 (39%), Gaps = 69/278 (24%)
Query: 205 RPCAPLEDECEAPLVCRAGCSPEHGFCEQPGE---CRCLEGWTGPLCTVPVSTSSCLSPR 261
+ C E +C+A C G G C G+ C C GW G C V SSCL
Sbjct: 707 KTCHSREFQCDA-YTCSNG-----GTCYDSGDTFRCACPPGWKGSTCAV-AKNSSCLP-- 757
Query: 262 GPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPC 321
NPC NGG+C + SF C C G+ G C + C PC
Sbjct: 758 -------------------NPCVNGGTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPC 798
Query: 322 FNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRA 381
+NGG+CV G + + C C PGF G +C +D C PC G C+D + RC C
Sbjct: 799 YNGGICVDGVN---WFRCECAPGFAGPDCRINIDECQSSPCAYGATCVDEINGYRCSCPP 855
Query: 382 GFAGPRCEHDLDDCAGRACANGGTCVEGGGA-----HRCSCALGFG-------------- 422
G AGPRC+ + GR+C + GT G + + C C G
Sbjct: 856 GRAGPRCQEVIG--FGRSCWSRGTPFPHGSSWVEDCNSCRCLDGRRDCSKVWCGWKPCLL 913
Query: 423 -------------GRDCRERAD-PCAARPCAHGGRCYA 446
G+ C E+A C PC G C A
Sbjct: 914 AGQPEALSAQCPLGQRCLEKAPGQCLRPPCEAWGECGA 951
Score = 36.6 bits (83), Expect = 0.066
Identities = 39/147 (26%), Positives = 48/147 (32%), Gaps = 23/147 (15%)
Query: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHG--F 230
+Y A C G C+ P R GP + C + G HG +
Sbjct: 837 AYGATCVDEINGYRCS------CPPGRAGPRCQEVIGFGRSCWS-----RGTPFPHGSSW 885
Query: 231 CEQPGECRCLEG-------WTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPC 283
E CRCL+G W G + LS + P CL PG C PC
Sbjct: 886 VEDCNSCRCLDGRRDCSKVWCGWKPCLLAGQPEALSAQCPLGQR--CLEKAPGQCLRPPC 943
Query: 284 ANGGSC-SETPRSFECTCPRGFYGLRC 309
G C +E P S C G C
Sbjct: 944 EAWGECGAEEPPSTPCLPRSGHLDNNC 970
>gi|4557679 jagged 1 precursor [Homo sapiens]
Length = 1218
Score = 213 bits (542), Expect = 4e-55
Identities = 147/495 (29%), Positives = 207/495 (41%), Gaps = 69/495 (13%)
Query: 1 MVSPRMSGLLSQTVILALIFLPQTRP-----AGVFELQIHSFGPGPGP-------GAPRS 48
M SPR G + + L L L R +G FEL+I S G G R+
Sbjct: 1 MRSPRTRGRSGRPLSLLLALLCALRAKVCGASGQFELEILSMQNVNGELQNGNCCGGARN 60
Query: 49 PCS---ARLPCRLFFRVCLKPGLSEEAAESPCALGAALSARGPVYTEQPGAPAPDLPLPD 105
P R C +F+VCLK S A PC+ G S PV G +L
Sbjct: 61 PGDRKCTRDECDTYFKVCLKEYQSRVTAGGPCSFG---SGSTPVI----GGNTFNLKASR 113
Query: 106 G----LLQVPFRDAWPGTFSFIIETWREELGDQIGGPAWSLLARVAGRRRLAAGGPWARD 161
G + +PF AWP +++ ++E W + D + S++ + + + W
Sbjct: 114 GNDRNRIVLPFSFAWPRSYTLLVEAW-DSSNDTVQPD--SIIEKASHSGMINPSRQWQTL 170
Query: 162 IQRAGAWELRFSYRARCEPPAVGTACTRLCRPRS---APSRCGP-GLRPCAP--LEDECE 215
Q G + R C+ G C + CRPR C G + C + EC
Sbjct: 171 KQNTGVAHFEYQIRVTCDDYYYGFGCNKFCRPRDDFFGHYACDQNGNKTCMEGWMGPECN 230
Query: 216 APLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGP 275
+CR GCSP+HG C+ PG+CRC GW G C C +P P
Sbjct: 231 RA-ICRQGCSPKHGSCKLPGDCRCQYGWQGLYC------DKC--------------IPHP 269
Query: 276 GPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG-PCFNGGLCVGGADPD 334
G C +G C+E ++C C + G C+ C PC NGG C PD
Sbjct: 270 G------CVHG-ICNEP---WQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTC-SNTGPD 318
Query: 335 SAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD 394
Y C CP G+ G NCE C PC N G C + C C G+ GP C ++DD
Sbjct: 319 K-YQCSCPEGYSGPNCEIAEHACLSDPCHNRGSCKETSLGFECECSPGWTGPTCSTNIDD 377
Query: 395 CAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCA 454
C+ C++GGTC + +C C + G+ C+ A+ C A+PC + C + C
Sbjct: 378 CSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSCKNLIASYYCD 437
Query: 455 CAPGYMGARCEFPVH 469
C PG+MG C+ ++
Sbjct: 438 CLPGWMGQNCDININ 452
Score = 180 bits (456), Expect = 4e-45
Identities = 82/231 (35%), Positives = 109/231 (47%), Gaps = 27/231 (11%)
Query: 236 ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRS 295
+C C +GW G C ++ C NPC NGG+C +
Sbjct: 652 KCICSDGWEGAYCETNIND-----------------------CSQNPCHNGGTCRDLVND 688
Query: 296 FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE-KRV 354
F C C G+ G C C + C NGG C D A+ C CP G++G+ C R
Sbjct: 689 FYCDCKNGWKGKTCHSRDSQCDEATCNNGGTCY---DEGDAFKCMCPGGWEGTTCNIARN 745
Query: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHR 414
C PC NGG C+ G + C C+ G+ GP C + +DC+ C N GTCV+G +R
Sbjct: 746 SSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDGDNWYR 805
Query: 415 CSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
C CA GF G DCR + C + PCA G C +G C C PG+ GA+C+
Sbjct: 806 CECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQ 856
Score = 138 bits (348), Expect = 1e-32
Identities = 79/272 (29%), Positives = 109/272 (40%), Gaps = 31/272 (11%)
Query: 219 VCRAGCSPEHGFCEQP-GECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGP 277
+C G + +H CE+ EC G C ++ CL P G S +
Sbjct: 474 ICPPGYAGDH--CERDIDECASNPCLNGGHCQNEINRFQCLCPTGFSGNLCQLDIDY--- 528
Query: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLC-VGGADPDSA 336
C+ NPC NG C + C CP + G C C PC C V A D+
Sbjct: 529 CEPNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTP 588
Query: 337 ------------------------YICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLG 372
+ C C GF G+ C + ++ C PCRNGG C+D
Sbjct: 589 EGVRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGV 648
Query: 373 HALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADP 432
++ +C C G+ G CE +++DC+ C NGGTC + C C G+ G+ C R
Sbjct: 649 NSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLVNDFYCDCKNGWKGKTCHSRDSQ 708
Query: 433 CAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
C C +GG CY C C G+ G C
Sbjct: 709 CDEATCNNGGTCYDEGDAFKCMCPGGWEGTTC 740
>gi|134244285 Notch homolog 3 [Homo sapiens]
Length = 2321
Score = 194 bits (493), Expect = 2e-49
Identities = 99/280 (35%), Positives = 128/280 (45%), Gaps = 43/280 (15%)
Query: 190 LCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG--ECRCLEGWTGP 246
LC P S P C P PCA + C HG C + PG C C GW+GP
Sbjct: 682 LCPPGSLPPLCLPPSHPCA--HEPC------------SHGICYDAPGGFRCVCEPGWSGP 727
Query: 247 LCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYG 306
C+ ++ + C+ PC GG+CS F CTCP G G
Sbjct: 728 RCSQSLARDA---------------------CESQPCRAGGTCSSDGMGFHCTCPPGVQG 766
Query: 307 LRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCS-LQPCRNG 365
+CE+ C PC +GG C P +C CP G+QG C++ VD C+ PC
Sbjct: 767 RQCELLS-PCTPNPCEHGGRCESA--PGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPH 823
Query: 366 GLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRD 425
G+C +L + C C G+ GP C+ D++DC C NGG+C +G G+ CSC GF G
Sbjct: 824 GICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPR 883
Query: 426 CRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
C D C + PC G C H + C C PGY G CE
Sbjct: 884 CARDVDECLSNPCG-PGTCTDHVASFTCTCPPGYGGFHCE 922
Score = 194 bits (492), Expect = 2e-49
Identities = 112/325 (34%), Positives = 144/325 (44%), Gaps = 39/325 (12%)
Query: 174 YRARCEPPAVGTACTRL----------CRPRSAPSRCGPGLRPCAP---LEDECEAPLVC 220
+R CEP G C++ CR S G G P +CE C
Sbjct: 716 FRCVCEPGWSGPRCSQSLARDACESQPCRAGGTCSSDGMGFHCTCPPGVQGRQCELLSPC 775
Query: 221 RAGCSPEHGFCEQ-PGE---CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTG------C 270
G CE PG+ C C +GW GP C V + +P GP T C
Sbjct: 776 TPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECAGPAPCGPHGICTNLAGSFSC 835
Query: 271 LVPG--PGP--------CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGP 320
G GP CD NPC NGGSC + SF C+C GF G RC C P
Sbjct: 836 TCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGSFSCSCLPGFAGPRCARDVDECLSNP 895
Query: 321 CFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCR 380
C G C D +++ C CPPG+ G +CE+ + CS C NGG C+D ++ C CR
Sbjct: 896 C-GPGTCT---DHVASFTCTCPPGYGGFHCEQDLPDCSPSSCFNGGTCVDGVNSFSCLCR 951
Query: 381 AGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAH 440
G+ G C+H+ D C R C +GG C RC+C F G C+ D C+ +PC +
Sbjct: 952 PGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCLESFTGPQCQTLVDWCSRQPCQN 1011
Query: 441 GGRCYAHFSGLVCACAPGYMGARCE 465
GGRC +G C C PG+ G C+
Sbjct: 1012 GGRCVQ--TGAYCLCPPGWSGRLCD 1034
Score = 180 bits (457), Expect = 3e-45
Identities = 124/404 (30%), Positives = 152/404 (37%), Gaps = 77/404 (19%)
Query: 144 ARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAV-GTACTRLCRPRSAPSRCGP 202
AR RRR P RA L + PP + G+ C R PSR
Sbjct: 5 ARGRRRRRRPMSPPPPPPPVRALPLLLLLAGPGAAAPPCLDGSPCANGGRCTQLPSREAA 64
Query: 203 GLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPG-------ECRCLEGWTGPLCTVPVSTS 255
L P + + C+ C +G G C+ CRC G+ GP C++P
Sbjct: 65 CLCPPGWVGERCQLEDPCHSGPCAGRGVCQSSVVAGTARFSCRCPRGFRGPDCSLP---D 121
Query: 256 SCLSPRGPSSATTGCLVPGPGP--CD-------------------GNPCANGGSCSETPR 294
CLS P + C V G C G PC +GG+C TP
Sbjct: 122 PCLS--SPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHGGTCLNTPG 179
Query: 295 SFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
SF C CP G+ G CE V CA PC NGG C D Y C C PGF+G NCE V
Sbjct: 180 SFRCQCPAGYTGPLCENPAVPCAPSPCRNGGTCRQSGD--LTYDCACLPGFEGQNCEVNV 237
Query: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCA--GRACANGGTCVEGGGA 412
D C C NGG C+D + C+C + G C D+D+C AC NGGTC G
Sbjct: 238 DDCPGHRCLNGGTCVDGVNTYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGG 297
Query: 413 HRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACA---------------- 456
H C C G+ G C + D CA C HG C+ + CAC
Sbjct: 298 HSCVCVNGWTGESCSQNIDDCATAVCFHGATCHDRVASFYCACPMGKTGLLCHLDDACVS 357
Query: 457 -----------------------PGYMGARCEFPVHPDGASALP 477
PG+ G C+ V A P
Sbjct: 358 NPCHEDAICDTNPVNGRAICTCPPGFTGGACDQDVDECSIGANP 401
Score = 180 bits (457), Expect = 3e-45
Identities = 111/334 (33%), Positives = 140/334 (41%), Gaps = 45/334 (13%)
Query: 173 SYRARCEPPAVGTACTR-LCRPRSAPSRCGPGL-------------------RPCAPLED 212
+Y +C P G CT + + P+ C G C+ D
Sbjct: 257 TYNCQCPPEWTGQFCTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNID 316
Query: 213 ECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSS------CLSPRGPSSA 266
+C A VC G + C C G TG LC + + S + P +
Sbjct: 317 DC-ATAVCFHGATCHDRVASF--YCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNG 373
Query: 267 TTGCLVPGP---GPCD---------GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGV 314
C P G CD NPC + G C T SF C C RG+ G RCE
Sbjct: 374 RAICTCPPGFTGGACDQDVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVN 433
Query: 315 TCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHA 374
C GPC N C+ D + C C GF G+ CE +D C PC NGG+C D +
Sbjct: 434 ECLSGPCRNQATCL---DRIGQFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRVNG 490
Query: 375 LRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCA 434
C C +GF+G C+ D+D+CA C NG CV+ + C CA GF G C D C+
Sbjct: 491 FSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDDCS 550
Query: 435 ARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPV 468
PC H GRC + CACAPGY G RCE V
Sbjct: 551 PDPC-HHGRCVDGIASFSCACAPGYTGTRCESQV 583
Score = 180 bits (457), Expect = 3e-45
Identities = 110/331 (33%), Positives = 138/331 (41%), Gaps = 71/331 (21%)
Query: 200 CGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGEC---------RCLEGWTGPLCTV 250
C PG A +D E C G +P CE G C +C G+TGP C
Sbjct: 379 CPPGFTGGACDQDVDE----CSIGANP----CEHLGRCVNTQGSFLCQCGRGYTGPRCET 430
Query: 251 PVST---------SSCLSPRGPSSATTGCLVPGPGP--------CDGNPCANGGSCSETP 293
V+ ++CL G T C+ G C +PC NGG C +
Sbjct: 431 DVNECLSGPCRNQATCLDRIG--QFTCICMAGFTGTYCEVDIDECQSSPCVNGGVCKDRV 488
Query: 294 RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD--------------------- 332
F CTCP GF G C++ CA PC NG CV D
Sbjct: 489 NGFSCTCPSGFSGSTCQLDVDECASTPCRNGAKCVDQPDGYECRCAEGFEGTLCDRNVDD 548
Query: 333 --PD-----------SAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRC 379
PD +++ C C PG+ G+ CE +VD C QPCR+GG CLDL CRC
Sbjct: 549 CSPDPCHHGRCVDGIASFSCACAPGYTGTRCESQVDECRSQPCRHGGKCLDLVDKYLCRC 608
Query: 380 RAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCA 439
+G G CE ++DDCA C G C +G + C C GF G C + CA+ PC
Sbjct: 609 PSGTTGVNCEVNIDDCASNPC-TFGVCRDGINRYDCVCQPGFTGPLCNVEINECASSPCG 667
Query: 440 HGGRCYAHFSGLVCACAPGYMGARCEFPVHP 470
GG C +G C C PG + C P HP
Sbjct: 668 EGGSCVDGENGFRCLCPPGSLPPLCLPPSHP 698
Score = 168 bits (426), Expect = 1e-41
Identities = 124/428 (28%), Positives = 157/428 (36%), Gaps = 125/428 (29%)
Query: 174 YRARCEPPAVGTACTRL--CRPRSAP--SRC--GPGLRP------------CAPLEDECE 215
+ C P G C L C P RC PG P C DEC
Sbjct: 756 FHCTCPPGVQGRQCELLSPCTPNPCEHGGRCESAPGQLPVCSCPQGWQGPRCQQDVDECA 815
Query: 216 APLVCRAGCSPEHGFCEQPG---ECRCLEGWTGPLCTVPVST---SSCLS----PRGPSS 265
P A C P HG C C C G+TGP C ++ + CL+ G S
Sbjct: 816 GP----APCGP-HGICTNLAGSFSCTCHGGYTGPSCDQDINDCDPNPCLNGGSCQDGVGS 870
Query: 266 ATTGCLVPGPGP--------CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCA 317
+ CL GP C NPC G +C++ SF CTCP G+ G CE C+
Sbjct: 871 FSCSCLPGFAGPRCARDVDECLSNPCGPG-TCTDHVASFTCTCPPGYGGFHCEQDLPDCS 929
Query: 318 DGPCFNGGLCVGG--------------------ADP---------------DSAYICHCP 342
CFNGG CV G ADP + C C
Sbjct: 930 PSSCFNGGTCVDGVNSFSCLCRPGYTGAHCQHEADPCLSRPCLHGGVCSAAHPGFRCTCL 989
Query: 343 PGFQGSNCEKRVDRCSLQPCRNGGLCLDLG----------------HALRCR-------- 378
F G C+ VD CS QPC+NGG C+ G +L CR
Sbjct: 990 ESFTGPQCQTLVDWCSRQPCQNGGRCVQTGAYCLCPPGWSGRLCDIRSLPCREAAAQIGV 1049
Query: 379 ----------------------CRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCS 416
C G G CE ++D C + C +GGTC G + C
Sbjct: 1050 RLEQLCQAGGQCVDEDSSHYCVCPEGRTGSHCEQEVDPCLAQPCQHGGTCRGYMGGYMCE 1109
Query: 417 CALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASAL 476
C G+ G +C + D CA++PC HGG C + +C+C PG +G CE ++ D
Sbjct: 1110 CLPGYNGDNCEDDVDECASQPCQHGGSCIDLVARYLCSCPPGTLGVLCE--INEDDCGPG 1167
Query: 477 PAAPPGLR 484
P G R
Sbjct: 1168 PPLDSGPR 1175
Score = 165 bits (417), Expect = 1e-40
Identities = 107/343 (31%), Positives = 135/343 (39%), Gaps = 85/343 (24%)
Query: 181 PAVGTACTRLCRPRSAPS-----RCGPGL--RPCAPLEDECEAPLVCRAGCSPEHGFC-E 232
P + + C R P C PG R C DEC CR G G C
Sbjct: 122 PCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSDVDECRVGEPCRHG-----GTCLN 176
Query: 233 QPGE--CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCS 290
PG C+C G+TGPLC P PC +PC NGG+C
Sbjct: 177 TPGSFRCQCPAGYTGPLCENPAV-----------------------PCAPSPCRNGGTCR 213
Query: 291 ET-PRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSN 349
++ +++C C GF G CEV+ C C NGG CV G + Y C CPP + G
Sbjct: 214 QSGDLTYDCACLPGFEGQNCEVNVDDCPGHRCLNGGTCVDGVN---TYNCQCPPEWTGQF 270
Query: 350 CEKRVDRCSLQP--CRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCV 407
C + VD C LQP C NGG C + C C G+ G C ++DDCA C +G TC
Sbjct: 271 CTEDVDECQLQPNACHNGGTCFNTLGGHSCVCVNGWTGESCSQNIDDCATAVCFHGATCH 330
Query: 408 EGGGAHRCSCALG---------------------------------------FGGRDCRE 428
+ + C+C +G F G C +
Sbjct: 331 DRVASFYCACPMGKTGLLCHLDDACVSNPCHEDAICDTNPVNGRAICTCPPGFTGGACDQ 390
Query: 429 RADPCA--ARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVH 469
D C+ A PC H GRC +C C GY G RCE V+
Sbjct: 391 DVDECSIGANPCEHLGRCVNTQGSFLCQCGRGYTGPRCETDVN 433
Score = 144 bits (362), Expect = 3e-34
Identities = 106/326 (32%), Positives = 123/326 (37%), Gaps = 43/326 (13%)
Query: 190 LCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRA-------GCSPEHGF--CEQP-GECRC 239
+C S C + PC L C+ CR C P + CE EC
Sbjct: 1071 VCPEGRTGSHCEQEVDPC--LAQPCQHGGTCRGYMGGYMCECLPGYNGDNCEDDVDECAS 1128
Query: 240 LEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVP------GPGP-CDGNP-CANGGSCSE 291
G C V+ C P G T G L GPGP D P C + G+C +
Sbjct: 1129 QPCQHGGSCIDLVARYLCSCPPG----TLGVLCEINEDDCGPGPPLDSGPRCLHNGTCVD 1184
Query: 292 TPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE 351
F CTCP G+ GLRCE C G C DP + C C GF G C+
Sbjct: 1185 LVGGFRCTCPPGYTGLRCEADINECRSGACHAAHTRDCLQDPGGGFRCLCHAGFSGPRCQ 1244
Query: 352 KRVDRCSLQPCRNGGLCLDL-----GHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTC 406
+ C QPC++GG C G C C F GPRCE C C G C
Sbjct: 1245 TVLSPCESQPCQHGGQCRPSPGPGGGLTFTCHCAQPFWGPRCERVARSCRELQCPVGVPC 1304
Query: 407 VEGGGAHRCSCALGFGGRDCRE--------RADPCAARPCAHGGRC----YAHFSGLVCA 454
+ RC+C G G CR CAA PC HGG C A F CA
Sbjct: 1305 QQTPRGPRCACPPGLSGPSCRSFPGSPPGASNASCAAAPCLHGGSCRPAPLAPF--FRCA 1362
Query: 455 CAPGYMGARCEFPVHPDGASALPAAP 480
CA G+ G RCE P S P P
Sbjct: 1363 CAQGWTGPRCEAPAAAPEVSEEPRCP 1388
Score = 115 bits (288), Expect = 1e-25
Identities = 70/178 (39%), Positives = 78/178 (43%), Gaps = 18/178 (10%)
Query: 316 CADG-PCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHA 374
C DG PC NGG C ++A C CPPG+ G C+ D C PC G+C A
Sbjct: 43 CLDGSPCANGGRCTQLPSREAA--CLCPPGWVGERCQLE-DPCHSGPCAGRGVCQSSVVA 99
Query: 375 ----LRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEG-GGAHRCSCALGFGGRDCRER 429
CRC GF GP C D C CA+G C G G CSC G+ GR CR
Sbjct: 100 GTARFSCRCPRGFRGPDCSLP-DPCLSSPCAHGARCSVGPDGRFLCSCPPGYQGRSCRSD 158
Query: 430 ADPC-AARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAPPGLRPG 486
D C PC HGG C C C GY G CE P A+P AP R G
Sbjct: 159 VDECRVGEPCRHGGTCLNTPGSFRCQCPAGYTGPLCENP-------AVPCAPSPCRNG 209
>gi|24041035 notch 2 preproprotein [Homo sapiens]
Length = 2471
Score = 193 bits (491), Expect = 3e-49
Identities = 102/286 (35%), Positives = 140/286 (48%), Gaps = 32/286 (11%)
Query: 200 CGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLS 259
C L PC+P + CE VC+ SP + C C GW G CT+ + C+S
Sbjct: 830 CQTVLAPCSP--NPCENAAVCKE--SPNF----ESYTCLCAPGWQGQRCTIDID--ECIS 879
Query: 260 P----RGPSSATTG---CLVPGPG-----------PCDGNPCANGGSCSETPRSFECTCP 301
G T G C P PG C NPC NGGSC + +F C C
Sbjct: 880 KPCMNHGLCHNTQGSYMCECP-PGFSGMDCEEDIDDCLANPCQNGGSCMDGVNTFSCLCL 938
Query: 302 RGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQP 361
GF G +C+ C PC NGG C +D ++Y C C GF G +CE ++ C+
Sbjct: 939 PGFTGDKCQTDMNECLSEPCKNGGTC---SDYVNSYTCKCQAGFDGVHCENNINECTESS 995
Query: 362 CRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGF 421
C NGG C+D ++ C C GF G C H++++C+ C N GTCV+G G +RCSC LG+
Sbjct: 996 CFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGY 1055
Query: 422 GGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFP 467
G++C+ + C+ PC + G C + C C G+ GA C+ P
Sbjct: 1056 TGKNCQTLVNLCSRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVP 1101
Score = 178 bits (452), Expect = 1e-44
Identities = 104/333 (31%), Positives = 136/333 (40%), Gaps = 50/333 (15%)
Query: 173 SYRARCEPPAVGTACTR----------------LCRPRSAPSRC----GPGLRPCAPLED 212
+Y RC P G CT C R+ C G C+ D
Sbjct: 281 TYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENID 340
Query: 213 ECEAPLVCRAGCSPEHGFCEQPGE--CRCLEGWTGPLCTVPVSTSS-------------- 256
+C A C+P ++ C C EG G LC + + S
Sbjct: 341 DCAF-----ASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPL 395
Query: 257 -----CLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEV 311
C P+G A V + NPC + G C T +F C C +G+ G RCE+
Sbjct: 396 NGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEM 455
Query: 312 SGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDL 371
C PC N C+ D + C C PGF+G +CE ++ C PC N G C+D
Sbjct: 456 DINECHSDPCQNDATCL---DKIGGFTCLCMPGFKGVHCELEINECQSNPCVNNGQCVDK 512
Query: 372 GHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERAD 431
+ +C C GF GP C+ D+DDC+ C NG C++ + C CA GF G C E D
Sbjct: 513 VNRFQCLCPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGYECQCATGFTGVLCEENID 572
Query: 432 PCAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
C PC H G+C C C PGYMGA C
Sbjct: 573 NCDPDPC-HHGQCQDGIDSYTCICNPGYMGAIC 604
Score = 176 bits (446), Expect = 5e-44
Identities = 85/230 (36%), Positives = 110/230 (47%), Gaps = 26/230 (11%)
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSF 296
C+CL G+TG C V+ C +PG C +GG+C P S+
Sbjct: 168 CKCLTGFTGQKCETDVNE---------------CDIPGH-------CQHGGTCLNLPGSY 205
Query: 297 ECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDR 356
+C CP+GF G C+ V CA PC NGG C D + C+C PGF+GS CE+ +D
Sbjct: 206 QCQCPQGFTGQYCDSLYVPCAPSPCVNGGTC--RQTGDFTFECNCLPGFEGSTCERNIDD 263
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDC--AGRACANGGTCVEGGGAHR 414
C C+NGG+C+D + CRC + G C D+D+C AC NGGTC G +
Sbjct: 264 CPNHRCQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVDECLLQPNACQNGGTCANRNGGYG 323
Query: 415 CSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
C C G+ G DC E D CA C G C + C C G G C
Sbjct: 324 CVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLC 373
Score = 173 bits (438), Expect = 5e-43
Identities = 111/341 (32%), Positives = 136/341 (39%), Gaps = 53/341 (15%)
Query: 173 SYRARCEPPAVGTACT--------------RLCRPR--SAPSRCGPGLR--PCAPLEDEC 214
SY C P G CT LC S C PG C D+C
Sbjct: 856 SYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSGMDCEEDIDDC 915
Query: 215 EAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTG----- 269
A C+ G S G C CL G+TG C ++ CLS + T
Sbjct: 916 LAN-PCQNGGSCMDGV--NTFSCLCLPGFTGDKCQTDMN--ECLSEPCKNGGTCSDYVNS 970
Query: 270 ----CLVPGPG--------PCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCA 317
C G C + C NGG+C + SF C CP GF G C C+
Sbjct: 971 YTCKCQAGFDGVHCENNINECTESSCFNGGTCVDGINSFSCLCPVGFTGSFCLHEINECS 1030
Query: 318 DGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRC 377
PC N G CV G Y C CP G+ G NC+ V+ CS PC+N G C+ +C
Sbjct: 1031 SHPCLNEGTCVDGL---GTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQC 1087
Query: 378 RCRAGFAGPRCEHDLDDCAGRA----------CANGGTCVEGGGAHRCSCALGFGGRDCR 427
C +G+AG C+ C A C + G C+ G H C C LG+ G C
Sbjct: 1088 LCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCE 1147
Query: 428 ERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPV 468
E+ D CA+ PC HG C G C C PGY G CE+ V
Sbjct: 1148 EQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEV 1188
Score = 169 bits (429), Expect = 5e-42
Identities = 84/258 (32%), Positives = 120/258 (46%), Gaps = 35/258 (13%)
Query: 237 CRCLEGWTGPLCTVPVSTSS------------------CLSPRGPSSATTGCLVPGPGPC 278
C C G+TG C ++ S C P G + LV C
Sbjct: 1011 CLCPVGFTGSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLV---NLC 1067
Query: 279 DGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTC----------ADGPCFNGGLCV 328
+PC N G+C + +C CP G+ G C+V V+C + C + G+C+
Sbjct: 1068 SRSPCKNKGTCVQKKAESQCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCI 1127
Query: 329 GGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRC 388
+ + C CP G+ GS CE+++D C+ PC++G C D RC C G+ G C
Sbjct: 1128 NAGN---THYCQCPLGYTGSYCEEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNC 1184
Query: 389 EHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARP-CAHGGRCYAH 447
E+++D+C + C NGGTC++ +CSC G G C E D CA P C +GG+C
Sbjct: 1185 EYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGLLCEENIDDCARGPHCLNGGQCMDR 1244
Query: 448 FSGLVCACAPGYMGARCE 465
G C C PG+ G RCE
Sbjct: 1245 IGGYSCRCLPGFAGERCE 1262
Score = 169 bits (427), Expect = 9e-42
Identities = 107/345 (31%), Positives = 143/345 (41%), Gaps = 48/345 (13%)
Query: 173 SYRARCEPPAVGTACTRLCRPRSAPSRC--GPGLRPCAPLEDECEA-PLVCRAGCS---- 225
SY+ +C G C L P APS C G R EC P + C
Sbjct: 204 SYQCQCPQGFTGQYCDSLYVP-CAPSPCVNGGTCRQTGDFTFECNCLPGFEGSTCERNID 262
Query: 226 --PEHGFCEQPG---------ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATT------ 268
P H C+ G CRC WTG CT V L P + T
Sbjct: 263 DCPNHR-CQNGGVCVDGVNTYNCRCPPQWTGQFCTEDVD-ECLLQPNACQNGGTCANRNG 320
Query: 269 --GCLVPGP----------GPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTC 316
GC+ C C G +C + SF C CP G GL C + C
Sbjct: 321 GYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASFSCMCPEGKAGLLCHLDDA-C 379
Query: 317 ADGPCFNGGLCVGGADP-DSAYICHCPPGFQGSNCEKRVDRCSL---QPCRNGGLCLDLG 372
PC G LC +P + YIC CP G++G++C + VD C++ PC + G C++
Sbjct: 380 ISNPCHKGALC--DTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCEHAGKCVNTD 437
Query: 373 HALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADP 432
A C C G+AGPRCE D+++C C N TC++ G C C GF G C +
Sbjct: 438 GAFHCECLKGYAGPRCEMDINECHSDPCQNDATCLDKIGGFTCLCMPGFKGVHCELEINE 497
Query: 433 CAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALP 477
C + PC + G+C + C C PG+ G C+ + D S+ P
Sbjct: 498 CQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDI--DDCSSTP 540
Score = 167 bits (422), Expect = 3e-41
Identities = 104/338 (30%), Positives = 140/338 (41%), Gaps = 79/338 (23%)
Query: 180 PPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG--E 236
P A G+ CT + S G + C +EC+ P C+ G G C PG +
Sbjct: 152 PCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHG-----GTCLNLPGSYQ 206
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSET-PRS 295
C+C +G+TG C PC +PC NGG+C +T +
Sbjct: 207 CQCPQGFTGQYCDSLYV-----------------------PCAPSPCVNGGTCRQTGDFT 243
Query: 296 FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVD 355
FEC C GF G CE + C + C NGG+CV G + Y C CPP + G C + VD
Sbjct: 244 FECNCLPGFEGSTCERNIDDCPNHRCQNGGVCVDGV---NTYNCRCPPQWTGQFCTEDVD 300
Query: 356 RCSLQP--CRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEG---- 409
C LQP C+NGG C + C C G++G C ++DDCA +C G TC++
Sbjct: 301 ECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTPGSTCIDRVASF 360
Query: 410 -----------------------------------GGAHRCSCALGFGGRDCRERADPCA 434
G + C+C G+ G DC E D CA
Sbjct: 361 SCMCPEGKAGLLCHLDDACISNPCHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECA 420
Query: 435 ---ARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVH 469
+ PC H G+C C C GY G RCE ++
Sbjct: 421 MANSNPCEHAGKCVNTDGAFHCECLKGYAGPRCEMDIN 458
Score = 159 bits (402), Expect = 7e-39
Identities = 89/297 (29%), Positives = 120/297 (40%), Gaps = 48/297 (16%)
Query: 177 RCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQP-- 234
RC G C C+P ++ C CA P + HG C
Sbjct: 621 RCIDLVNGYQCN--CQPGTSGVNCEINFDDCA------SNPCI--------HGICMDGIN 664
Query: 235 -GECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETP 293
C C G+TG C + + C NPC G +C
Sbjct: 665 RYSCVCSPGFTGQRCNIDIDE-----------------------CASNPCRKGATCINGV 701
Query: 294 RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKR 353
F C CP G + C C PC +G C GG S Y C C G+ G NCE
Sbjct: 702 NGFRCICPEGPHHPSCYSQVNECLSNPCIHGN-CTGGL---SGYKCLCDAGWVGINCEVD 757
Query: 354 VDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAH 413
+ C PC+NGG C +L + RC C+ GF G C+ ++D+CA C N GTC + +
Sbjct: 758 KNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCFDDISGY 817
Query: 414 RCSCALGFGGRDCRERADPCAARPCAHGGRC--YAHFSGLVCACAPGYMGARCEFPV 468
C C L + G++C+ PC+ PC + C +F C CAPG+ G RC +
Sbjct: 818 TCHCVLPYTGKNCQTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQRCTIDI 874
Score = 157 bits (396), Expect = 3e-38
Identities = 93/326 (28%), Positives = 134/326 (41%), Gaps = 64/326 (19%)
Query: 200 CGPGLR-PCAPLE-DECEA-PLVCRAGCSPE-HGFCEQPGECRCLEGWTGPLCTVPVSTS 255
C PG P ++ D+C + P + A C +G+ EC+C G+TG LC +
Sbjct: 520 CPPGFTGPVCQIDIDDCSSTPCLNGAKCIDHPNGY-----ECQCATGFTGVLCEENIDNC 574
Query: 256 S---CLSPRGPSSATTGCLVPGPG-----------PCDGNPCANGGSCSETPRSFECTCP 301
C + + + PG C +PC N G C + ++C C
Sbjct: 575 DPDPCHHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQ 634
Query: 302 RGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQP 361
G G+ CE++ CA PC +G +C+ G + Y C C PGF G C +D C+ P
Sbjct: 635 PGTSGVNCEINFDDCASNPCIHG-ICMDGIN---RYSCVCSPGFTGQRCNIDIDECASNP 690
Query: 362 CRNGGLCLDLGHALRC-------------------------------------RCRAGFA 384
CR G C++ + RC C AG+
Sbjct: 691 CRKGATCINGVNGFRCICPEGPHHPSCYSQVNECLSNPCIHGNCTGGLSGYKCLCDAGWV 750
Query: 385 GPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRC 444
G CE D ++C C NGGTC +RC+C GF G +C+ D CA+ PC + G C
Sbjct: 751 GINCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTC 810
Query: 445 YAHFSGLVCACAPGYMGARCEFPVHP 470
+ SG C C Y G C+ + P
Sbjct: 811 FDDISGYTCHCVLPYTGKNCQTVLAP 836
Score = 155 bits (392), Expect = 1e-37
Identities = 118/391 (30%), Positives = 145/391 (37%), Gaps = 96/391 (24%)
Query: 173 SYRARCEPPAVGTACTRL--------------CRPRSAPSRCGPGLRPCAPLEDECEAPL 218
+YR C G C L C + A S+C L P C+ P
Sbjct: 1046 TYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTCVQKKAESQC---LCPSGWAGAYCDVPN 1102
Query: 219 VC------RAGCSPEH-----GFCEQPGE---CRCLEGWTGPLCTVPVSTSSCLSPRGPS 264
V R G EH G C G C+C G+TG C + C S
Sbjct: 1103 VSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQCPLGYTGSYCEEQLD--ECASNPCQH 1160
Query: 265 SATTGCLVPG------PG-----------PCDGNPCANGGSCSETPRSFECTCPRGFYGL 307
AT + G PG C PC NGG+C + F+C+CP G GL
Sbjct: 1161 GATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLVNHFKCSCPPGTRGL 1220
Query: 308 RCEVSGVTCADGP-CFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGG 366
CE + CA GP C NGG C+ D Y C C PGF G CE ++ C PC + G
Sbjct: 1221 LCEENIDDCARGPHCLNGGQCM---DRIGGYSCRCLPGFAGERCEGDINECLSNPCSSEG 1277
Query: 367 L--CLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG---AHRCSCALGF 421
C+ L + C CR+ F G CE +D C C NGGTC C C GF
Sbjct: 1278 SLDCIQLTNDYLCVCRSAFTGRHCETFVDVCPQMPCLNGGTCAVASNMPDGFICRCPPGF 1337
Query: 422 GGRDC-----------------------------RERADPCAARPCAHGGRCYAHFSG-- 450
G C R+ CA+ PC HGG C+
Sbjct: 1338 SGARCQSSCGQVKCRKGEQCVHTASGPRCFCPSPRDCESGCASSPCQHGGSCHPQRQPPY 1397
Query: 451 LVCACAPGYMGARCEFPVHPDGASALPAAPP 481
C CAP + G+RCE P P+ PP
Sbjct: 1398 YSCQCAPPFSGSRCELYTAP------PSTPP 1422
Score = 144 bits (362), Expect = 3e-34
Identities = 90/268 (33%), Positives = 113/268 (42%), Gaps = 44/268 (16%)
Query: 214 CEAP---LVCRAGCSP--EHGFC----EQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPS 264
C AP L CR G P G C G C+C EG+ G C
Sbjct: 19 CAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGEYCQ--------------- 63
Query: 265 SATTGCLVPGPGPCDGNPCANGGSCSETPR--SFECTCPRGFYGLRCEVS-GVTC-ADGP 320
PC+ N C NGG+C C C GF G C+ S C P
Sbjct: 64 ---------HRDPCEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRP 114
Query: 321 CFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCR 380
C NGG C Y C C GF G C+ D C PC NG C + + C+C
Sbjct: 115 CLNGGTC--HMLSRDTYECTCQVGFTGKECQW-TDACLSHPCANGSTCTTVANQFSCKCL 171
Query: 381 AGFAGPRCEHDLDDC-AGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCA 439
GF G +CE D+++C C +GGTC+ G+++C C GF G+ C PCA PC
Sbjct: 172 TGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCV 231
Query: 440 HGGRC--YAHFSGLVCACAPGYMGARCE 465
+GG C F+ C C PG+ G+ CE
Sbjct: 232 NGGTCRQTGDFT-FECNCLPGFEGSTCE 258
Score = 112 bits (279), Expect = 1e-24
Identities = 61/162 (37%), Positives = 82/162 (50%), Gaps = 13/162 (8%)
Query: 316 CADG--PCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLD--- 370
C DG PC N G+CV + C CP GF G C+ R D C C+NGG C+
Sbjct: 28 CRDGYEPCVNEGMCV--TYHNGTGYCKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAM 84
Query: 371 LGHALRCRCRAGFAGPRCEHDLDD--CAGRACANGGTC-VEGGGAHRCSCALGFGGRDCR 427
LG A CRC +GF G C++ R C NGGTC + + C+C +GF G++C
Sbjct: 85 LGKAT-CRCASGFTGEDCQYSTSHPCFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC- 142
Query: 428 ERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVH 469
+ D C + PCA+G C + C C G+ G +CE V+
Sbjct: 143 QWTDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVN 184
Score = 105 bits (261), Expect = 2e-22
Identities = 86/296 (29%), Positives = 111/296 (37%), Gaps = 65/296 (21%)
Query: 200 CGPGLRP--CAPLEDECEAPLVCRAGCSPEHGFC-EQPG--ECRCLEGWTGPLCTVPVST 254
C PG R C D+C C G G C ++ G CRCL G+ G C ++
Sbjct: 1213 CPPGTRGLLCEENIDDCARGPHCLNG-----GQCMDRIGGYSCRCLPGFAGERCEGDIN- 1266
Query: 255 SSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGS--CSETPRSFECTCPRGFYGLRCEVS 312
CLS NPC++ GS C + + C C F G CE
Sbjct: 1267 -ECLS---------------------NPCSSEGSLDCIQLTNDYLCVCRSAFTGRHCETF 1304
Query: 313 GVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLG 372
C PC NGG C ++ +IC CPPGF G+ C+ C CR G C+
Sbjct: 1305 VDVCPQMPCLNGGTCAVASNMPDGFICRCPPGFSGARCQ---SSCGQVKCRKGEQCVHTA 1361
Query: 373 HALRCRCRAGFAGPR-CEHDLDDCAGRACANGGTC--VEGGGAHRCSCALGFGGRDCRER 429
RC C PR CE CA C +GG+C + C CA F G C
Sbjct: 1362 SGPRCFC----PSPRDCE---SGCASSPCQHGGSCHPQRQPPYYSCQCAPPFSGSRCELY 1414
Query: 430 ADP-------CAARPCAHGGR-------CYAH---FSGLVCACAPGYMGARCEFPV 468
P C ++ CA R C +H + G C+ A C P+
Sbjct: 1415 TAPPSTPPATCLSQYCADKARDGVCDEACNSHACQWDGGDCSLTMENPWANCSSPL 1470
>gi|148833508 notch1 preproprotein [Homo sapiens]
Length = 2555
Score = 184 bits (467), Expect = 2e-46
Identities = 96/296 (32%), Positives = 124/296 (41%), Gaps = 47/296 (15%)
Query: 174 YRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQ 233
Y+ C P G C + L PCAP CR G +
Sbjct: 813 YKCNCLLPYTGATCEVV-------------LAPCAPSP--------CRNGGECRQSEDYE 851
Query: 234 PGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETP 293
C C GW G C V ++ C +PC +G SC T
Sbjct: 852 SFSCVCPTGWQGQTCEVDINE-----------------------CVLSPCRHGASCQNTH 888
Query: 294 RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKR 353
+ C C G+ G CE C PC NGG C G + C C PGF+G+ CE+
Sbjct: 889 GGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGIN---TAFCDCLPGFRGTFCEED 945
Query: 354 VDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAH 413
++ C+ PCRNG C D + C C AGF+G CE++ DC +C NGGTCV+G +
Sbjct: 946 INECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSF 1005
Query: 414 RCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVH 469
C C GF G C+ + C ++PC HGG C C C GY G C+ VH
Sbjct: 1006 TCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVH 1061
Score = 181 bits (459), Expect = 2e-45
Identities = 98/305 (32%), Positives = 134/305 (43%), Gaps = 44/305 (14%)
Query: 188 TRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGE---CRCLEGWT 244
T LCRP C + C+ CR G G C+ C CL+G T
Sbjct: 588 TCLCRPGYTGHHCETNINECSSQP--------CRHG-----GTCQDRDNAYLCFCLKGTT 634
Query: 245 GPLCTV--------PVSTSSCLSPRG-------PSSATTGCLVPGPGPCDGNPCANGGSC 289
GP C + P + +CL P + C + C GNPC NGG+C
Sbjct: 635 GPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNI-NIDECAGNPCHNGGTC 693
Query: 290 SETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSN 349
+ F C CP G++ C C PC +G D + Y C C PG+ G+N
Sbjct: 694 EDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGAC----RDSLNGYKCDCDPGWSGTN 749
Query: 350 CEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEG 409
C+ + C PC NGG C D+ C CR GF+GP C+ ++++CA C N GTC++
Sbjct: 750 CDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDD 809
Query: 410 GGAHRCSCALGFGGRDCRERADPCAARPCAHGGRC-----YAHFSGLVCACAPGYMGARC 464
++C+C L + G C PCA PC +GG C Y FS C C G+ G C
Sbjct: 810 VAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFS---CVCPTGWQGQTC 866
Query: 465 EFPVH 469
E ++
Sbjct: 867 EVDIN 871
Score = 178 bits (452), Expect = 1e-44
Identities = 99/304 (32%), Positives = 130/304 (42%), Gaps = 65/304 (21%)
Query: 220 CRAGCSPEHGFCEQPG---------ECRCLEGWTGPLCTVPVST---------SSCLSPR 261
C G +P CE G EC+CL+G+TGP C + V+ ++CL
Sbjct: 416 CSLGANP----CEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQI 471
Query: 262 G-------PSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGV 314
G P C V C +PC + G C + F+C CP GF G C+
Sbjct: 472 GEFQCICMPGYEGVHCEV-NTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVD 530
Query: 315 TCADGPCFNGGLCVGG-----------------------ADPD-----------SAYICH 340
CA PC NG C+ G DPD + + C
Sbjct: 531 ECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCL 590
Query: 341 CPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRAC 400
C PG+ G +CE ++ CS QPCR+GG C D +A C C G GP CE +LDDCA C
Sbjct: 591 CRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPC 650
Query: 401 ANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYM 460
+ GTC++ + C+C G+ G C D CA PC +GG C +G C C GY
Sbjct: 651 -DSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYH 709
Query: 461 GARC 464
C
Sbjct: 710 DPTC 713
Score = 177 bits (448), Expect = 3e-44
Identities = 99/300 (33%), Positives = 128/300 (42%), Gaps = 54/300 (18%)
Query: 188 TRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPL 247
T LC P S C + C C C+ GC C C +G+TGP
Sbjct: 1006 TCLCPPGFTGSYCQHDVNECD--SQPCLHGGTCQDGCGSYR--------CTCPQGYTGPN 1055
Query: 248 CTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGL 307
C V CD +PC NGG C +T + C CP G+ GL
Sbjct: 1056 CQNLVHW-----------------------CDSSPCKNGGKCWQTHTQYRCECPSGWTGL 1092
Query: 308 RCEVSGVTCADGP----------CFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRC 357
C+V V+C C +GGLCV D + + C C G+ GS CE VD C
Sbjct: 1093 YCDVPSVSCEVAAQRQGVDVARLCQHGGLCV---DAGNTHHCRCQAGYTGSYCEDLVDEC 1149
Query: 358 SLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSC 417
S PC+NG C D C+C AG+ G C ++D+C C NGGTC++ ++CSC
Sbjct: 1150 SPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSC 1209
Query: 418 ALGFGG-------RDCRERADPCAARP-CAHGGRCYAHFSGLVCACAPGYMGARCEFPVH 469
G G DC DP + P C + G C G C C PG++G RCE V+
Sbjct: 1210 PRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVN 1269
Score = 172 bits (436), Expect = 8e-43
Identities = 81/229 (35%), Positives = 105/229 (45%), Gaps = 25/229 (10%)
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSF 296
C C G+TGP C+ V S NPC + G C T SF
Sbjct: 398 CTCPSGYTGPACSQDVDECSL---------------------GANPCEHAGKCINTLGSF 436
Query: 297 ECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDR 356
EC C +G+ G RCE+ C PC N C+ D + C C PG++G +CE D
Sbjct: 437 ECQCLQGYTGPRCEIDVNECVSNPCQNDATCL---DQIGEFQCICMPGYEGVHCEVNTDE 493
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCS 416
C+ PC + G CLD + +C C GF G C++D+D+CA C NG C++G + C
Sbjct: 494 CASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCV 553
Query: 417 CALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
C G+ G C D C PC H G C + C C PGY G CE
Sbjct: 554 CTEGYTGTHCEVDIDECDPDPC-HYGSCKDGVATFTCLCRPGYTGHHCE 601
Score = 171 bits (434), Expect = 1e-42
Identities = 98/303 (32%), Positives = 133/303 (43%), Gaps = 25/303 (8%)
Query: 178 CEPPAVGTACTR-LCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQ-PG 235
C P GT C + S P R G C C AG S H CE
Sbjct: 933 CLPGFRGTFCEEDINECASDPCRNGANCTDCVD-----SYTCTCPAGFSGIH--CENNTP 985
Query: 236 ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRS 295
+C + G C +++ +CL P G T CD PC +GG+C + S
Sbjct: 986 DCTESSCFNGGTCVDGINSFTCLCPPG---FTGSYCQHDVNECDSQPCLHGGTCQDGCGS 1042
Query: 296 FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVD 355
+ CTCP+G+ G C+ C PC NGG C + Y C CP G+ G C+
Sbjct: 1043 YRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCW---QTHTQYRCECPSGWTGLYCDVPSV 1099
Query: 356 RCSLQP----------CRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGT 405
C + C++GGLC+D G+ CRC+AG+ G CE +D+C+ C NG T
Sbjct: 1100 SCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGAT 1159
Query: 406 CVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
C + G + C C G+ G +C E D C + PC +GG C + C+C G G CE
Sbjct: 1160 CTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCE 1219
Query: 466 FPV 468
V
Sbjct: 1220 INV 1222
Score = 166 bits (419), Expect = 7e-41
Identities = 101/317 (31%), Positives = 126/317 (39%), Gaps = 36/317 (11%)
Query: 177 RCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGE 236
RC P C + C G P C+ P C + G C
Sbjct: 23 RCSQPGETCLNGGKCEAANGTEACVCGGAFVGP---RCQDPNPCLSTPCKNAGTCHVVDR 79
Query: 237 -------CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLV---------PG------ 274
C C G++GPLC P+ ++CL+ + T L PG
Sbjct: 80 RGVADYACSCALGFSGPLCLTPLD-NACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSC 138
Query: 275 --PGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGP--CFNGGLCVGG 330
PC NPCANGG C S+ C CP F+G C C P C +GG C
Sbjct: 139 QQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNE 198
Query: 331 ADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALR-CRCRAGFAGPRCE 389
+Y C C G NCE+ CS PC+NGG C G C C GF G CE
Sbjct: 199 V---GSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCE 255
Query: 390 HDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARP--CAHGGRCYAH 447
++DDC G C NGG CV+G + C C + G+ C E D C P C +GG C+
Sbjct: 256 ENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNT 315
Query: 448 FSGLVCACAPGYMGARC 464
G C C G+ G C
Sbjct: 316 HGGYNCVCVNGWTGEDC 332
Score = 158 bits (399), Expect = 2e-38
Identities = 95/321 (29%), Positives = 128/321 (39%), Gaps = 56/321 (17%)
Query: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEA-PLVCRAG--CSPEHG 229
+Y RC P G CT DEC+ P C+ G C HG
Sbjct: 278 TYNCRCPPEWTGQYCTEDV--------------------DECQLMPNACQNGGTCHNTHG 317
Query: 230 FCEQPGECRCLEGWTGPLCTVPVSTSS------------------CLSPRGPSSATTGCL 271
C C+ GWTG C+ + + C P G TG L
Sbjct: 318 GYN----CVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHG----RTGLL 369
Query: 272 VPGPGPCDGNPCANGGSCSETPRSFE--CTCPRGFYGLRCEVSGVTCADG--PCFNGGLC 327
C NPC G +C P + + CTCP G+ G C C+ G PC + G C
Sbjct: 370 CHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKC 429
Query: 328 VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPR 387
+ ++ C C G+ G CE V+ C PC+N CLD +C C G+ G
Sbjct: 430 INTL---GSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVH 486
Query: 388 CEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAH 447
CE + D+CA C + G C++ +C C GF G C+ D CA+ PC +G +C
Sbjct: 487 CEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDG 546
Query: 448 FSGLVCACAPGYMGARCEFPV 468
+ C C GY G CE +
Sbjct: 547 PNTYTCVCTEGYTGTHCEVDI 567
Score = 155 bits (393), Expect = 7e-38
Identities = 103/324 (31%), Positives = 129/324 (39%), Gaps = 36/324 (11%)
Query: 174 YRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDE--CEAPL-----VCRAG--- 223
Y+ RC P G +C + S P C G + C P E C P CR
Sbjct: 125 YKCRCPPGWSGKSCQQADPCASNP--CANGGQ-CLPFEASYICHCPPSFHGPTCRQDVNE 181
Query: 224 CSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPC 283
C + G C G C G +C + +C P P C +PC
Sbjct: 182 CGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVP--------------CSPSPC 227
Query: 284 ANGGSCSETPR-SFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCP 342
NGG+C T + EC C GF G CE + C C NGG CV G + Y C CP
Sbjct: 228 QNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVN---TYNCRCP 284
Query: 343 PGFQGSNCEKRVDRCSLQP--CRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRAC 400
P + G C + VD C L P C+NGG C + C C G+ G C ++DDCA AC
Sbjct: 285 PEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAAC 344
Query: 401 ANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAH--FSGLVCACAPG 458
+G TC + + C C G G C D C + PC G C + +C C G
Sbjct: 345 FHGATCHDRVASFYCECPHGRTGLLCHLN-DACISNPCNEGSNCDTNPVNGKAICTCPSG 403
Query: 459 YMGARCEFPVHPDGASALPAAPPG 482
Y G C V A P G
Sbjct: 404 YTGPACSQDVDECSLGANPCEHAG 427
Score = 141 bits (355), Expect = 2e-33
Identities = 109/390 (27%), Positives = 142/390 (36%), Gaps = 94/390 (24%)
Query: 168 WELRFSYRARCEPPAVGTACTRLCRPRSAPS-RCGPGLRPCAPLEDECEAPLVCRAGCSP 226
W+ YR C G C PS C A + +C+ G
Sbjct: 1075 WQTHTQYRCECPSGWTGLYC-------DVPSVSC-----EVAAQRQGVDVARLCQHG--- 1119
Query: 227 EHGFCEQPGE---CRCLEGWTGPLCTVPV---STSSCLSPRGPSSATTG----CLVPGPG 276
G C G CRC G+TG C V S S C + + G C+ G
Sbjct: 1120 --GLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHG 1177
Query: 277 --------PCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTC--------ADGP 320
C +PC NGG+C + P +++C+CPRG G+ CE++ C
Sbjct: 1178 VNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPK 1237
Query: 321 CFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSL--------------------- 359
CFN G CV D Y C CPPGF G CE V+ C
Sbjct: 1238 CFNNGTCV---DQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCE 1294
Query: 360 -------------------QPCRNGGLCLDLGHALR---CRCRAGFAGPRCEHDLDDCAG 397
+PC+NGG C + R C+C AGF G CE+D C
Sbjct: 1295 CRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGS 1354
Query: 398 RACANGGTCVEGGGAHRCSCALGFGGRDCR-ERADPC-AARPCAHGGRC--YAHFSGLVC 453
C NGGTC+ G + C C F G +C+ + PC PC + G C + C
Sbjct: 1355 LRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRC 1414
Query: 454 ACAPGYMGARCEFPVHPDGASALPAAPPGL 483
C + G C + G A PP L
Sbjct: 1415 LCPAKFNGLLCHILDYSFGGGAGRDIPPPL 1444
Score = 130 bits (327), Expect = 3e-30
Identities = 74/201 (36%), Positives = 89/201 (44%), Gaps = 17/201 (8%)
Query: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCV-----GGADPD 334
G C NGG C + C C F G RC+ C PC N G C G AD
Sbjct: 28 GETCLNGGKCEAANGTEACVCGGAFVGPRCQDPN-PCLSTPCKNAGTCHVVDRRGVAD-- 84
Query: 335 SAYICHCPPGFQGSNCEKRVDR-CSLQPCRNGGLC--LDLGHALRCRCRAGFAGPRCEHD 391
Y C C GF G C +D C PCRNGG C L L +CRC G++G C+
Sbjct: 85 --YACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTE-YKCRCPPGWSGKSCQQ- 140
Query: 392 LDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARP--CAHGGRCYAHFS 449
D CA CANGG C+ ++ C C F G CR+ + C +P C HGG C+
Sbjct: 141 ADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVG 200
Query: 450 GLVCACAPGYMGARCEFPVHP 470
C C + G CE P P
Sbjct: 201 SYRCVCRATHTGPNCERPYVP 221
Score = 105 bits (262), Expect = 1e-22
Identities = 60/173 (34%), Positives = 82/173 (47%), Gaps = 16/173 (9%)
Query: 306 GLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNG 365
G RC G TC NGG C ++ C C F G C+ + C PC+N
Sbjct: 21 GPRCSQPGETC-----LNGGKCEAANGTEA---CVCGGAFVGPRCQDP-NPCLSTPCKNA 71
Query: 366 GLCLDLGHA----LRCRCRAGFAGPRCEHDLDD-CAGRACANGGTC-VEGGGAHRCSCAL 419
G C + C C GF+GP C LD+ C C NGGTC + ++C C
Sbjct: 72 GTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPP 131
Query: 420 GFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDG 472
G+ G+ C++ ADPCA+ PCA+GG+C + +C C P + G C V+ G
Sbjct: 132 GWSGKSCQQ-ADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECG 183
>gi|55770876 notch4 preproprotein [Homo sapiens]
Length = 2003
Score = 184 bits (467), Expect = 2e-46
Identities = 106/294 (36%), Positives = 133/294 (45%), Gaps = 37/294 (12%)
Query: 201 GPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGE--CRCLEGWTGPLC---------- 248
G G C D+C A A C+P ++ G C C G TG LC
Sbjct: 346 GWGGTSCEENLDDCIA-----ATCAPGSTCIDRVGSFSCLCPPGRTGLLCHLEDMCLSQP 400
Query: 249 --------TVPVSTSS-CLSPRGPSSATTG-----CLVPGPGPCDGNPCANGGSCSETPR 294
T P++ S+ CL G S T CL+ GP +PC +GGSC TP
Sbjct: 401 CHGDAQCSTNPLTGSTLCLCQPGYSGPTCHQDLDECLMAQQGP---SPCEHGGSCLNTPG 457
Query: 295 SFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
SF C CP G+ G RCE C PC G C+ D + + C CPPG +G CE
Sbjct: 458 SFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCL---DLLATFHCLCPPGLEGQLCEVET 514
Query: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHR 414
+ C+ PC N C DL + +C C GF+G RCE D+D+C CANGG C + GA
Sbjct: 515 NECASAPCLNHADCHDLLNGFQCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGAFH 574
Query: 415 CSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPV 468
C C GF G C+ D C + PC G C C C G+ G CE P+
Sbjct: 575 CKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVPL 628
Score = 182 bits (462), Expect = 7e-46
Identities = 102/309 (33%), Positives = 122/309 (39%), Gaps = 51/309 (16%)
Query: 178 CEPPAVGTACTRLCRPRS--------APSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHG 229
CE P LC+P+ A C G CAP ED C HG
Sbjct: 624 CEVPL---CAPNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTC----------HHG 670
Query: 230 FCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSC 289
C++ C C GWTGP C + G C PCA+GG+C
Sbjct: 671 HCQR-SSCVCDVGWTGPECEAEL-----------------------GGCISAPCAHGGTC 706
Query: 290 SETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPD-SAYICHCPPGFQGS 348
P + CTCP G+ G C C GPC NGG C +P Y C CPP G
Sbjct: 707 YPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSC----NPSPGGYYCTCPPSHTGP 762
Query: 349 NCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDL-DDCAGRACANGGTCV 407
C+ D C PC NGG C++ C C GF GPRCE L CA C N TC
Sbjct: 763 QCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQ 822
Query: 408 EGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFP 467
+ RC C G+ G C+ D CA +PC C C C G+ G C P
Sbjct: 823 DSPQGPRCLCPTGYTGGSCQTLMDLCAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLP 882
Query: 468 VHPDGASAL 476
+ +AL
Sbjct: 883 LSSCQKAAL 891
Score = 176 bits (447), Expect = 4e-44
Identities = 118/370 (31%), Positives = 142/370 (38%), Gaps = 80/370 (21%)
Query: 173 SYRARCEPPAVGTACTRLCRPRSAPSRC-----------GPG-LRPCAPLEDECEAPL-V 219
++ C G C RP A S C GP L P C+ + +
Sbjct: 788 TFSCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDL 847
Query: 220 CRAGCSPEHGFCEQPG---ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPG 276
C P + C Q G C CL+GWTGPLC +P+S SC L
Sbjct: 848 CAQKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLS--SCQKAALSQGIDVSSL----- 900
Query: 277 PCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSA 336
C NGG C ++ S+ C CP GF G C+ C PC NG C+ A P S
Sbjct: 901 ------CHNGGLCVDSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCM--AQP-SG 951
Query: 337 YICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCA 396
Y+C C PG+ G NC K +D C QPC N G C C C GF G RCE D+D+C
Sbjct: 952 YLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECL 1011
Query: 397 GRACANGGT--CVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYA-------- 446
+ C GT C A C C G G+ C DPC ++PC HGG C A
Sbjct: 1012 DQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQPCFHGGTCEATAGSPLGF 1071
Query: 447 -------------------------HFSGLV-----------CACAPGYMGARCEFPVHP 470
H GL CAC GY G C P P
Sbjct: 1072 ICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPRCACLSGYGGPDCLTPPAP 1131
Query: 471 DGASALPAAP 480
G P +P
Sbjct: 1132 KGCG--PPSP 1139
Score = 169 bits (428), Expect = 7e-42
Identities = 106/300 (35%), Positives = 126/300 (42%), Gaps = 34/300 (11%)
Query: 187 CTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGP 246
CT C P RC A LED C + G H +C C+ GWTG
Sbjct: 103 CT--CLPGFTGERCQ------AKLEDPCPPSFCSKRGRC--HIQASGRPQCSCMPGWTGE 152
Query: 247 LCTVP--VSTSSCLSPRGPSSAT---TGCLVPGPG-----------PC--DGNPCANGGS 288
C + S + C++ G AT C P PG C D PC G S
Sbjct: 153 QCQLRDFCSANPCVNG-GVCLATYPQIQCHCP-PGFEGHACERDVNECFQDPGPCPKGTS 210
Query: 289 CSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAY-ICHCPPGFQG 347
C T SF+C CP G G RCE+ C C NGG C + DS + +C CPPGF G
Sbjct: 211 CHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPGFIG 270
Query: 348 SNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRA---CANGG 404
+CE D C C+NGG C D C C + G C D+D+C + C NGG
Sbjct: 271 PDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCRNGG 330
Query: 405 TCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
TC G+ C C G+GG C E D C A CA G C C C PG G C
Sbjct: 331 TCQNSAGSFHCVCVSGWGGTSCEENLDDCIAATCAPGSTCIDRVGSFSCLCPPGRTGLLC 390
Score = 167 bits (423), Expect = 2e-41
Identities = 104/323 (32%), Positives = 133/323 (41%), Gaps = 47/323 (14%)
Query: 178 CEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPG-- 235
C P G CT PS GP C D C + A C +PG
Sbjct: 744 CNPSPGGYYCT------CPPSHTGP---QCQTSTDYCVS-----APCFNGGTCVNRPGTF 789
Query: 236 ECRCLEGWTGPLCTVPVSTS----------SCL-SPRGP-----SSATTGCLVPGPGPCD 279
C C G+ GP C + S +C SP+GP + T G C
Sbjct: 790 SCLCAMGFQGPRCEGKLRPSCADSPCRNRATCQDSPQGPRCLCPTGYTGGSCQTLMDLCA 849
Query: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGP----------CFNGGLCVG 329
PC C +T SF C C +G+ G C + +C C NGGLCV
Sbjct: 850 QKPCPRNSHCLQTGPSFHCLCLQGWTGPLCNLPLSSCQKAALSQGIDVSSLCHNGGLCV- 908
Query: 330 GADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE 389
D +Y CHCPPGFQGS C+ V+ C +PC+NG C+ C+C G+ G C
Sbjct: 909 --DSGPSYFCHCPPGFQGSLCQDHVNPCESRPCQNGATCMAQPSGYLCQCAPGYDGQNCS 966
Query: 390 HDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGG--RCYAH 447
+LD C + C N GTC G C+C GF G C D C +PC G C++
Sbjct: 967 KELDACQSQPCHNHGTCTPKPGGFHCACPPGFVGLRCEGDVDECLDQPCHPTGTAACHSL 1026
Query: 448 FSGLVCACAPGYMGARCEFPVHP 470
+ C C PG+ G CE + P
Sbjct: 1027 ANAFYCQCLPGHTGQWCEVEIDP 1049
Score = 151 bits (382), Expect = 1e-36
Identities = 105/363 (28%), Positives = 139/363 (38%), Gaps = 67/363 (18%)
Query: 173 SYRARCEPPAVGTAC--------TRLCRPRSA--------PSRCGPGLRP--CAPLEDEC 214
S+ C P G+ C ++ C P S C PGL C +EC
Sbjct: 458 SFNCLCPPGYTGSRCEADHNECLSQPCHPGSTCLDLLATFHCLCPPGLEGQLCEVETNEC 517
Query: 215 -EAPLVCRAGCSPE-HGFCEQPGECRCLEGWTGPLCTVPVS---TSSCLS----PRGPSS 265
AP + A C +GF +C CL G++G C + +S C + P +
Sbjct: 518 ASAPCLNHADCHDLLNGF-----QCICLPGFSGTRCEEDIDECRSSPCANGGQCQDQPGA 572
Query: 266 ATTGCLVPGPGP--------CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCA 317
CL GP C +PC G SC + P +F C CP GF G CEV CA
Sbjct: 573 FHCKCLPGFEGPRCQTEVDECLSDPCPVGASCLDLPGAFFCLCPSGFTGQLCEVP--LCA 630
Query: 318 DGPCFNGGLCV---------------GGADPDSAYICH----------CPPGFQGSNCEK 352
C +C G A P+ CH C G+ G CE
Sbjct: 631 PNLCQPKQICKDQKDKANCLCPDGSPGCAPPEDNCTCHHGHCQRSSCVCDVGWTGPECEA 690
Query: 353 RVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGA 412
+ C PC +GG C C C G+ GP C ++ C C NGG+C G
Sbjct: 691 ELGGCISAPCAHGGTCYPQPSGYNCTCPTGYTGPTCSEEMTACHSGPCLNGGSCNPSPGG 750
Query: 413 HRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDG 472
+ C+C G C+ D C + PC +GG C C CA G+ G RCE + P
Sbjct: 751 YYCTCPPSHTGPQCQTSTDYCVSAPCFNGGTCVNRPGTFSCLCAMGFQGPRCEGKLRPSC 810
Query: 473 ASA 475
A +
Sbjct: 811 ADS 813
Score = 147 bits (370), Expect = 3e-35
Identities = 104/326 (31%), Positives = 126/326 (38%), Gaps = 44/326 (13%)
Query: 179 EPPAVGTACTRLCRPRSAPSRCGPG-LRPCAPLEDECEAPLVCRAGCSPEH------GFC 231
EP A G C L + +C PG L D C+ +C+ G S + G
Sbjct: 33 EPCANGGTCLSLSLGQGT-CQCAPGFLGETCQFPDPCQNAQLCQNGGSCQALLPAPLGLP 91
Query: 232 EQPGE------CRCLEGWTGPLCTV----PVSTSSCLSPRG------PSSATTGCLVPGP 275
P C CL G+TG C P S C S RG C+
Sbjct: 92 SSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFC-SKRGRCHIQASGRPQCSCMPGWT 150
Query: 276 GP-------CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCAD--GPCFNGGL 326
G C NPC NGG C T +C CP GF G CE C GPC G
Sbjct: 151 GEQCQLRDFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCPKGTS 210
Query: 327 CVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALR----CRCRAG 382
C ++ C CP G +G CE R C + C NGG C + C C G
Sbjct: 211 CHNTL---GSFQCLCPVGQEGPRCELRAGPCPPRGCSNGGTCQLMPEKDSTFHLCLCPPG 267
Query: 383 FAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARP---CA 439
F GP CE + D+C C NGGTC +G + C C + G DC E D C + C
Sbjct: 268 FIGPDCEVNPDNCVSHQCQNGGTCQDGLDTYTCLCPETWTGWDCSEDVDECETQGPPHCR 327
Query: 440 HGGRCYAHFSGLVCACAPGYMGARCE 465
+GG C C C G+ G CE
Sbjct: 328 NGGTCQNSAGSFHCVCVSGWGGTSCE 353
Score = 119 bits (299), Expect = 6e-27
Identities = 96/325 (29%), Positives = 116/325 (35%), Gaps = 84/325 (25%)
Query: 200 CGPGLRPC--APLEDECEAPLVCRAGCSPEHGFCEQPGE---CRCLEGWTGPLC---TVP 251
C L C A L + +C G G C G C C G+ G LC P
Sbjct: 879 CNLPLSSCQKAALSQGIDVSSLCHNG-----GLCVDSGPSYFCHCPPGFQGSLCQDHVNP 933
Query: 252 VSTSSCLSPRGPSSATTGCLVP-GPG-----------PCDGNPCANGGSCSETPRSFECT 299
+ C + + +G L PG C PC N G+C+ P F C
Sbjct: 934 CESRPCQNGATCMAQPSGYLCQCAPGYDGQNCSKELDACQSQPCHNHGTCTPKPGGFHCA 993
Query: 300 CPRGFYGLRCEVSGVTCADGPC-------------------------------------- 321
CP GF GLRCE C D PC
Sbjct: 994 CPPGFVGLRCEGDVDECLDQPCHPTGTAACHSLANAFYCQCLPGHTGQWCEVEIDPCHSQ 1053
Query: 322 --FNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDL---GHALR 376
F+GG C A +ICHCP GF+G C R C C +GGLCL G R
Sbjct: 1054 PCFHGGTCEATAGSPLGFICHCPKGFEGPTCSHRAPSCGFHHCHHGGLCLPSPKPGFPPR 1113
Query: 377 CRCRAGFAGPRCEHDLDDCAGRACA------NGGTCVE----GGGAHRCSCALGFGGRDC 426
C C +G+ GP C L A + C G+C E GG RCSC G C
Sbjct: 1114 CACLSGYGGPDC---LTPPAPKGCGPPSPCLYNGSCSETTGLGGPGFRCSCPHSSPGPRC 1170
Query: 427 RE-RADPCAARPCAHGGRCYAHFSG 450
++ A C R + G C A SG
Sbjct: 1171 QKPGAKGCEGR--SGDGACDAGCSG 1193
Score = 103 bits (258), Expect = 3e-22
Identities = 68/218 (31%), Positives = 87/218 (39%), Gaps = 32/218 (14%)
Query: 282 PCANGGSC-SETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD-------- 332
PCANGG+C S + C C GF G C+ PC N LC G
Sbjct: 34 PCANGGTCLSLSLGQGTCQCAPGFLGETCQFPD------PCQNAQLCQNGGSCQALLPAP 87
Query: 333 ---PDS------AYICHCPPGFQGSNCEKRV-DRCSLQPCRNGGLC-LDLGHALRCRCRA 381
P S +++C C PGF G C+ ++ D C C G C + +C C
Sbjct: 88 LGLPSSPSPLTPSFLCTCLPGFTGERCQAKLEDPCPPSFCSKRGRCHIQASGRPQCSCMP 147
Query: 382 GFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARP--CA 439
G+ G +C+ D C+ C NGG C+ +C C GF G C + C P C
Sbjct: 148 GWTGEQCQLR-DFCSANPCVNGGVCLATYPQIQCHCPPGFEGHACERDVNECFQDPGPCP 206
Query: 440 HGGRCYAHFSGLVCACAPGYMGARCEF---PVHPDGAS 474
G C+ C C G G RCE P P G S
Sbjct: 207 KGTSCHNTLGSFQCLCPVGQEGPRCELRAGPCPPRGCS 244
Score = 59.3 bits (142), Expect = 1e-08
Identities = 62/225 (27%), Positives = 79/225 (35%), Gaps = 55/225 (24%)
Query: 225 SPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCA 284
SP+ GF P C CL G+ GP C P + C GP S PC
Sbjct: 1105 SPKPGF---PPRCACLSGYGGPDCLTPPAPKGC----GPPS----------------PCL 1141
Query: 285 NGGSCSETPR----SFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICH 340
GSCSET F C+CP G RC+ G +G +G G + P
Sbjct: 1142 YNGSCSETTGLGGPGFRCSCPHSSPGPRCQKPGAKGCEGRSGDGACDAGCSGPGG----- 1196
Query: 341 CPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDC-AGRA 399
+ G +C V + C + C L +C + C D DC A
Sbjct: 1197 ---NWDGGDCSLGVPD-PWKGCPSHSRCWLLFRDGQCHPQCD--SEECLFDGYDCETPPA 1250
Query: 400 CA-----------NGGTCVEGGGAHRCSCALGFGGRDCR-ERADP 432
C + G C +G C G+ G DCR E DP
Sbjct: 1251 CTPAYDQYCHDHFHNGHCEKGCNTAEC----GWDGGDCRPEDGDP 1291
>gi|45593147 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 177 bits (450), Expect = 2e-44
Identities = 118/329 (35%), Positives = 142/329 (43%), Gaps = 55/329 (16%)
Query: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279
C + C HG C G CRC GW G C V C
Sbjct: 29 CSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGC---------------------- 66
Query: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCA-DGPCFNGGLCVGGADPDSAYI 338
G+C + ++C C G+ G C+ C PC NGG C+ D Y
Sbjct: 67 -----QHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM--YDGGGEYH 116
Query: 339 CHCPPGFQGSNCEKRVDRCSL--QPCRNGGLCLD-LGHALR--CRCRAGFAGPRCEHDLD 393
C C PGF G +CE++ C PCRNGG C D G AL CRC GF G RCE ++D
Sbjct: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
Query: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVC 453
DC R CANG TC++G C C GF GR C D CA+RPC G RC C
Sbjct: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
Query: 454 ACAPGYMGARCE--FPVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALL 511
C GY G CE PV PD + + P P ++ PA G A AGA LL
Sbjct: 237 LCPSGYGGKTCELVLPV-PDPPTTVDT------PLGPTSAVVVPATG--PAPHSAGAGLL 287
Query: 512 LVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540
+ V+ Q+ AG EPS+ AL
Sbjct: 288 RISVKEVVRRQE------AGLGEPSLVAL 310
>gi|45545431 EGF-like-domain, multiple 9 [Homo sapiens]
Length = 383
Score = 177 bits (450), Expect = 2e-44
Identities = 118/329 (35%), Positives = 142/329 (43%), Gaps = 55/329 (16%)
Query: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCD 279
C + C HG C G CRC GW G C V C
Sbjct: 29 CSSHCDLAHGCCAPDGSCRCDPGWEGLHCERCVRMPGC---------------------- 66
Query: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCA-DGPCFNGGLCVGGADPDSAYI 338
G+C + ++C C G+ G C+ C PC NGG C+ D Y
Sbjct: 67 -----QHGTCHQP---WQCICHSGWAGKFCDKDEHICTTQSPCQNGGQCM--YDGGGEYH 116
Query: 339 CHCPPGFQGSNCEKRVDRCSL--QPCRNGGLCLD-LGHALR--CRCRAGFAGPRCEHDLD 393
C C PGF G +CE++ C PCRNGG C D G AL CRC GF G RCE ++D
Sbjct: 117 CVCLPGFHGRDCERKAGPCEQAGSPCRNGGQCQDDQGFALNFTCRCLVGFVGARCEVNVD 176
Query: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVC 453
DC R CANG TC++G C C GF GR C D CA+RPC G RC C
Sbjct: 177 DCLMRPCANGATCLDGINRFSCLCPEGFAGRFCTINLDDCASRPCQRGARCRDRVHDFDC 236
Query: 454 ACAPGYMGARCE--FPVHPDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALL 511
C GY G CE PV PD + + P P ++ PA G A AGA LL
Sbjct: 237 LCPSGYGGKTCELVLPV-PDPPTTVDT------PLGPTSAVVVPATG--PAPHSAGAGLL 287
Query: 512 LVHVRRRGHSQDAGSRLLAGTPEPSVHAL 540
+ V+ Q+ AG EPS+ AL
Sbjct: 288 RISVKEVVRRQE------AGLGEPSLVAL 310
>gi|148886654 polydom [Homo sapiens]
Length = 3571
Score = 174 bits (440), Expect = 3e-43
Identities = 84/240 (35%), Positives = 108/240 (45%), Gaps = 29/240 (12%)
Query: 229 GFCEQPGE---CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCAN 285
G C+Q G C C G+TG C + S L PC N
Sbjct: 1206 GTCQQLGRGYVCLCPLGYTGLKCETDIDECSPL-----------------------PCLN 1242
Query: 286 GGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGF 345
G C + F C CP G+ G RCE + C+ PC N G+CV G + Y C C GF
Sbjct: 1243 NGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGV---AGYRCTCVKGF 1299
Query: 346 QGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGT 405
G +CE V+ C PC N +C D C+C GF G RC ++D+C + C NG T
Sbjct: 1300 VGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGAT 1359
Query: 406 CVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
C +G + RC CA GF G C + C + PC + C + C C PG+ G RCE
Sbjct: 1360 CKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGKRCE 1419
Score = 169 bits (429), Expect = 5e-42
Identities = 71/192 (36%), Positives = 99/192 (51%), Gaps = 3/192 (1%)
Query: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAY 337
C NPC N G+C + R + C CP G+ GL+CE C+ PC N G+C D +
Sbjct: 1197 CFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVC---KDLVGEF 1253
Query: 338 ICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG 397
IC CP G+ G CE+ ++ CS PC N G+C+D RC C GF G CE ++++C
Sbjct: 1254 ICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYRCTCVKGFVGLHCETEVNECQS 1313
Query: 398 RACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAP 457
C N C + G C C GF G C + D C ++PC +G C + C CA
Sbjct: 1314 NPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQPCKNGATCKDGANSFRCLCAA 1373
Query: 458 GYMGARCEFPVH 469
G+ G+ CE ++
Sbjct: 1374 GFTGSHCELNIN 1385
Score = 77.0 bits (188), Expect = 4e-14
Identities = 45/141 (31%), Positives = 60/141 (42%), Gaps = 41/141 (29%)
Query: 216 APLVCRAGCS---PEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLV 272
+P +CRA C G C++P C C EGW G LC P+ C++
Sbjct: 3464 SPPICRAVCRFPCQNGGICQRPNACSCPEGWMGRLCEEPI-----------------CIL 3506
Query: 273 PGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD 332
PC NGG C ++C CP G+ G RC + PC NGG CV
Sbjct: 3507 ---------PCLNGGRC---VAPYQCDCPPGWTGSRCHTA---VCQSPCLNGGKCV---R 3548
Query: 333 PDSAYICHCPPGFQGSNCEKR 353
P+ CHC + G NC ++
Sbjct: 3549 PNR---CHCLSSWTGHNCSRK 3566
Score = 74.7 bits (182), Expect = 2e-13
Identities = 42/107 (39%), Positives = 50/107 (46%), Gaps = 18/107 (16%)
Query: 282 PCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHC 341
PC NGG C R C+CP G+ G CE PC NGG CV + Y C C
Sbjct: 3475 PCQNGGICQ---RPNACSCPEGWMGRLCEEPICIL---PCLNGGRCV------APYQCDC 3522
Query: 342 PPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRC 388
PPG+ GS C V + PC NGG C+ RC C + + G C
Sbjct: 3523 PPGWTGSRCHTAVCQ---SPCLNGGKCV---RPNRCHCLSSWTGHNC 3563
Score = 64.3 bits (155), Expect = 3e-10
Identities = 27/72 (37%), Positives = 34/72 (47%)
Query: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVC 453
+C C N GTC + G + C C LG+ G C D C+ PC + G C +C
Sbjct: 1196 ECFFNPCHNSGTCQQLGRGYVCLCPLGYTGLKCETDIDECSPLPCLNNGVCKDLVGEFIC 1255
Query: 454 ACAPGYMGARCE 465
C GY G RCE
Sbjct: 1256 ECPSGYTGQRCE 1267
Score = 63.9 bits (154), Expect = 4e-10
Identities = 38/110 (34%), Positives = 50/110 (45%), Gaps = 18/110 (16%)
Query: 320 PCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRC 379
PC NGG+C C CP G+ G CE+ + C L PC NGG C+ +C C
Sbjct: 3475 PCQNGGIC------QRPNACSCPEGWMGRLCEEPI--CIL-PCLNGGRCVA---PYQCDC 3522
Query: 380 RAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRER 429
G+ G RC + C NGG CV +RC C + G +C +
Sbjct: 3523 PPGWTGSRCHTAV---CQSPCLNGGKCVR---PNRCHCLSSWTGHNCSRK 3566
Score = 55.5 bits (132), Expect = 1e-07
Identities = 29/69 (42%), Positives = 35/69 (50%), Gaps = 9/69 (13%)
Query: 400 CANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGY 459
C NGG C + CSC G+ GR C E P PC +GGRC A + C C PG+
Sbjct: 3476 CQNGGICQR---PNACSCPEGWMGRLCEE---PICILPCLNGGRCVAPYQ---CDCPPGW 3526
Query: 460 MGARCEFPV 468
G+RC V
Sbjct: 3527 TGSRCHTAV 3535
Score = 54.3 bits (129), Expect = 3e-07
Identities = 37/140 (26%), Positives = 49/140 (35%), Gaps = 35/140 (25%)
Query: 176 ARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPG 235
A CE G C C P +RCG + C L C+ C+ G +
Sbjct: 1320 AVCEDQVGGFLCK--CPPGFLGTRCGKNVDEC--LSQPCKNGATCKDGANSFR------- 1368
Query: 236 ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRS 295
C C G+TG C + ++ C NPC N +C + S
Sbjct: 1369 -CLCAAGFTGSHCELNINE-----------------------CQSNPCRNQATCVDELNS 1404
Query: 296 FECTCPRGFYGLRCEVSGVT 315
+ C C GF G RCE T
Sbjct: 1405 YSCKCQPGFSGKRCETEQST 1424
Score = 32.3 bits (72), Expect = 1.2
Identities = 20/76 (26%), Positives = 35/76 (46%), Gaps = 8/76 (10%)
Query: 391 DLDDCA-GRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAH------GGR 443
D+D+CA G C+ +C+ G++ CSC + G D + A+P + + G
Sbjct: 1745 DVDECAVGSDCSEHASCLNVDGSYICSCVPPYTG-DGKNCAEPIKCKAPGNPENGHSSGE 1803
Query: 444 CYAHFSGLVCACAPGY 459
Y + + +C GY
Sbjct: 1804 IYTVGAEVTFSCQEGY 1819
Score = 31.6 bits (70), Expect = 2.1
Identities = 32/123 (26%), Positives = 45/123 (36%), Gaps = 22/123 (17%)
Query: 283 CANGGSCSETPRS--FECTCPRGFYGLRCEVSGVTCADGPC----FNGGL--CVGGADPD 334
C GSC + FEC C +G+YG + C G GG+ C+ D +
Sbjct: 288 CDRMGSCKCGTHTGHFECICEKGYYGKGLQYECTACPSGTYKPEGSPGGISSCIPCPDEN 347
Query: 335 --------SAYICHCPPGFQGSNCEKRVDRC-SLQPCRNGGLCLD-----LGHALRCRCR 380
S C C G++ S + C +L+P NG + A RC
Sbjct: 348 HTSPPGSTSPEDCVCREGYRASGQTCELVHCPALKPPENGYFIQNTCNNHFNAACGVRCH 407
Query: 381 AGF 383
GF
Sbjct: 408 PGF 410
Score = 30.8 bits (68), Expect = 3.6
Identities = 13/32 (40%), Positives = 18/32 (56%), Gaps = 3/32 (9%)
Query: 437 PCAHGGRCYAHFSGLVCACAPGYMGARCEFPV 468
PC +GG C + C+C G+MG CE P+
Sbjct: 3475 PCQNGGICQRPNA---CSCPEGWMGRLCEEPI 3503
>gi|41327708 crumbs homolog 1 precursor [Homo sapiens]
Length = 1406
Score = 173 bits (438), Expect = 5e-43
Identities = 89/263 (33%), Positives = 122/263 (46%), Gaps = 30/263 (11%)
Query: 205 RPCAPLEDECEA-PLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGP 263
+ C ++D C + P A C G E+ C+C G++G +C +
Sbjct: 65 KDCDNMKDPCFSNPCQGSATCVNTPG--ERSFLCKCPPGYSGTICETTI----------- 111
Query: 264 SSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFN 323
G C N C +GG C + P C CP G+ G CE+ CA PC N
Sbjct: 112 ------------GSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDECASSPCQN 159
Query: 324 GGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGF 383
G +C G D Y C C PG+QG +C+ VD C+ PC+N CL+ C C +
Sbjct: 160 GAVCQDGID---GYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCICPHNY 216
Query: 384 AGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGR 443
+G CE ++D+C + C NG TC + GA+ C CA GF G C D CA++PC HGG
Sbjct: 217 SGVNCELEIDECWSQPCLNGATCQDALGAYFCDCAPGFLGDHCELNTDECASQPCLHGGL 276
Query: 444 CYAHFSGLVCAC-APGYMGARCE 465
C + C C G+ G CE
Sbjct: 277 CVDGENRYSCNCTGSGFTGTHCE 299
Score = 156 bits (395), Expect = 4e-38
Identities = 96/319 (30%), Positives = 125/319 (39%), Gaps = 34/319 (10%)
Query: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCE 232
S+ +C P GT C S G+ P+ C +C AG + FCE
Sbjct: 93 SFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVC----ICPAGYAGR--FCE 146
Query: 233 -QPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSE 291
EC G +C + SC G V C +PC N +C
Sbjct: 147 IDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVD---ECASDPCKNEATCLN 203
Query: 292 TPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE 351
+ C CP + G+ CE+ C PC NG C D AY C C PGF G +CE
Sbjct: 204 EIGRYTCICPHNYSGVNCELEIDECWSQPCLNGATC---QDALGAYFCDCAPGFLGDHCE 260
Query: 352 KRVDRCSLQPCRNGGLCLDLGHALRCRCR-AGFAGPRCEHDLDDCAGRACANGGTCVEGG 410
D C+ QPC +GGLC+D + C C +GF G CE + C + C N TC +
Sbjct: 261 LNTDECASQPCLHGGLCVDGENRYSCNCTGSGFTGTHCETLMPLCWSKPCHNNATCEDSV 320
Query: 411 GAHRCSCALGFGGRDCRERADPCAARPCAHGGRC--------------------YAHFSG 450
+ C C G+ G C + C + PC G C Y SG
Sbjct: 321 DNYTCHCWPGYTGAQCEIDLNECNSNPCQSNGECVELSSEKQYGRITGLPSSFSYHEASG 380
Query: 451 LVCACAPGYMGARCEFPVH 469
VC C PG+ G CE V+
Sbjct: 381 YVCICQPGFTGIHCEEDVN 399
Score = 150 bits (378), Expect = 4e-36
Identities = 81/251 (32%), Positives = 112/251 (44%), Gaps = 32/251 (12%)
Query: 228 HGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGG 287
HGF +P E + L+ +ST+S + TGCL C+ NPC +GG
Sbjct: 1114 HGFINKPQEEQFLK----------ISTNSVV---------TGCLQLNV--CNSNPCLHGG 1152
Query: 288 SCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQG 347
+C + S+ C+CP G+ G CE++ C PC +G +D +AY C C PG+ G
Sbjct: 1153 NCEDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGNC----SDRVAAYHCTCEPGYTG 1208
Query: 348 SNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDL-------DDCAGRAC 400
NCE +D C C NG C+ + C C F G C ++ C
Sbjct: 1209 VNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTVCGNEKTNLTC 1268
Query: 401 ANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYM 460
NGG C E +C C GF G C + D CA+ PC +GG C + C C +
Sbjct: 1269 YNGGNCTEFQTELKCMCRPGFTGEWCEKDIDECASDPCVNGGLCQDLLNKFQCLCDVAFA 1328
Query: 461 GARCEFPVHPD 471
G RCE + D
Sbjct: 1329 GERCEVDLADD 1339
Score = 135 bits (339), Expect = 1e-31
Identities = 62/193 (32%), Positives = 86/193 (44%), Gaps = 3/193 (1%)
Query: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLR--CEVSGVTCADGPCFNGGLCVGGADPDS 335
C N C N +C + + +C+C L C+ C PC CV +
Sbjct: 34 CLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGSATCVN-TPGER 92
Query: 336 AYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDC 395
+++C CPPG+ G+ CE + C C++GG+C C C AG+AG CE D D+C
Sbjct: 93 SFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAGRFCEIDHDEC 152
Query: 396 AGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCAC 455
A C NG C +G + C C G+ GR C D CA+ PC + C C C
Sbjct: 153 ASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEVDECASDPCKNEATCLNEIGRYTCIC 212
Query: 456 APGYMGARCEFPV 468
Y G CE +
Sbjct: 213 PHNYSGVNCELEI 225
Score = 120 bits (300), Expect = 5e-27
Identities = 62/175 (35%), Positives = 81/175 (46%), Gaps = 13/175 (7%)
Query: 316 CADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHAL 375
C PC +GG C D S+Y C CP G+ G +CE +D C PC +G C D A
Sbjct: 1143 CNSNPCLHGGNC---EDIYSSYHCSCPLGWSGKHCELNIDECFSNPCIHGN-CSDRVAAY 1198
Query: 376 RCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAA 435
C C G+ G CE D+D+C CANG TC+ + C C F G+ CR+ P
Sbjct: 1199 HCTCEPGYTGVNCEVDIDNCQSHQCANGATCISHTNGYSCLCFGNFTGKFCRQSRLPSTV 1258
Query: 436 -------RPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAPPGL 483
C +GG C + L C C PG+ G CE + D ++ P GL
Sbjct: 1259 CGNEKTNLTCYNGGNCTEFQTELKCMCRPGFTGEWCEKDI--DECASDPCVNGGL 1311
Score = 77.8 bits (190), Expect = 3e-14
Identities = 42/165 (25%), Positives = 56/165 (33%), Gaps = 42/165 (25%)
Query: 346 QGSNCEKRVDRCSLQPCRNGGLCLDLG--------------------------------- 372
+ S C K RC C+N C D
Sbjct: 23 KNSFCNKNNTRCLSNSCQNNSTCKDFSKDNDCSCSDTANNLDKDCDNMKDPCFSNPCQGS 82
Query: 373 ---------HALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGG 423
+ C+C G++G CE + C +C +GG C + C C G+ G
Sbjct: 83 ATCVNTPGERSFLCKCPPGYSGTICETTIGSCGKNSCQHGGICHQDPIYPVCICPAGYAG 142
Query: 424 RDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPV 468
R C D CA+ PC +G C G C C PGY G C+ V
Sbjct: 143 RFCEIDHDECASSPCQNGAVCQDGIDGYSCFCVPGYQGRHCDLEV 187
Score = 64.7 bits (156), Expect = 2e-10
Identities = 32/81 (39%), Positives = 39/81 (48%), Gaps = 7/81 (8%)
Query: 278 CDGNPCANGGSCSETPRSFECTCP-----RGFYGLR-CEVSGVTCADGPCFNGGLCVGG- 330
C NPC NGG+C P ++ C CP R FYG R C + C C N G C+
Sbjct: 401 CSSNPCQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCTHQQCLNNGTCIPHF 460
Query: 331 ADPDSAYICHCPPGFQGSNCE 351
D + C CP G+ GS CE
Sbjct: 461 QDGQHGFSCLCPSGYTGSLCE 481
Score = 46.2 bits (108), Expect = 8e-05
Identities = 24/63 (38%), Positives = 27/63 (42%), Gaps = 3/63 (4%)
Query: 265 SATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNG 324
+ T GC G C NPC NGG C F C+CP G CE C PC +G
Sbjct: 880 NVTQGCA--GDNSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHG 936
Query: 325 GLC 327
C
Sbjct: 937 AQC 939
Score = 43.5 bits (101), Expect = 5e-04
Identities = 20/61 (32%), Positives = 23/61 (37%), Gaps = 1/61 (1%)
Query: 393 DDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV 452
+ C C NGG C CSC G+ C E C PC HG +C G
Sbjct: 889 NSCKSNPCHNGGVCHSRWDDFSCSCPALTSGKAC-EEVQWCGFSPCPHGAQCQPVLQGFE 947
Query: 453 C 453
C
Sbjct: 948 C 948
Score = 38.1 bits (87), Expect = 0.023
Identities = 14/36 (38%), Positives = 21/36 (58%)
Query: 353 RVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRC 388
R D C QPC++ G C++L + +C C + GP C
Sbjct: 672 RKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 38.1 bits (87), Expect = 0.023
Identities = 20/68 (29%), Positives = 26/68 (38%), Gaps = 1/68 (1%)
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCS 416
C PC NGG+C C C A +G CE ++ C C +G C C
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACE-EVQWCGFSPCPHGAQCQPVLQGFECI 949
Query: 417 CALGFGGR 424
F G+
Sbjct: 950 ANAVFNGQ 957
Score = 35.4 bits (80), Expect = 0.15
Identities = 24/96 (25%), Positives = 33/96 (34%), Gaps = 12/96 (12%)
Query: 231 CEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSC- 289
C+ G C L G C + + R S GC C N G+C
Sbjct: 406 CQNGGTCENLPGNYTCHCPFDNLSRTFYGGRDCSDILLGCT--------HQQCLNNGTCI 457
Query: 290 ---SETPRSFECTCPRGFYGLRCEVSGVTCADGPCF 322
+ F C CP G+ G CE++ +G F
Sbjct: 458 PHFQDGQHGFSCLCPSGYTGSLCEIATTLSFEGDGF 493
Score = 33.5 bits (75), Expect = 0.56
Identities = 16/51 (31%), Positives = 22/51 (43%), Gaps = 6/51 (11%)
Query: 433 CAARPCAHGGRCYAHFSGLVCACAPGYMGARCE------FPVHPDGASALP 477
C + PC +GG C++ + C+C G CE F P GA P
Sbjct: 891 CKSNPCHNGGVCHSRWDDFSCSCPALTSGKACEEVQWCGFSPCPHGAQCQP 941
Score = 31.6 bits (70), Expect = 2.1
Identities = 11/32 (34%), Positives = 16/32 (50%)
Query: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRC 309
C+ PC + G C S++C C R + G C
Sbjct: 676 CESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
Score = 30.4 bits (67), Expect = 4.7
Identities = 13/36 (36%), Positives = 16/36 (44%)
Query: 429 RADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
R D C ++PC GRC + C C Y G C
Sbjct: 672 RKDWCESQPCQSRGRCINLWLSYQCDCHRPYEGPNC 707
>gi|112420992 crumbs homolog 2 [Homo sapiens]
Length = 1285
Score = 170 bits (430), Expect = 4e-42
Identities = 80/196 (40%), Positives = 105/196 (53%), Gaps = 18/196 (9%)
Query: 275 PGPCDGNPCANGGSCSETPRSFECTC----PRGFYGLRCEVSGVTCADGPCFNGGLCVGG 330
P C +PCA G C T S TC PRG CA PC +G LCV
Sbjct: 39 PSACASDPCAPGTECQAT-ESGGYTCGPMEPRG------------CATQPCHHGALCVPQ 85
Query: 331 ADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEH 390
+ + C+C PGFQG CE +D C+ +PC +G C +L C C G+AG CE
Sbjct: 86 GPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPLGYAGVTCEM 145
Query: 391 DLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSG 450
++D+CA C +GG+C++G G+ RC CA G+GG C+ D C ++PCAHGG C+ +G
Sbjct: 146 EVDECASAPCLHGGSCLDGVGSFRCVCAPGYGGTRCQLDLDECQSQPCAHGGTCHDLVNG 205
Query: 451 LVCACA-PGYMGARCE 465
C CA GY G CE
Sbjct: 206 FRCDCAGTGYEGTHCE 221
Score = 166 bits (421), Expect = 4e-41
Identities = 104/322 (32%), Positives = 132/322 (40%), Gaps = 47/322 (14%)
Query: 184 GTACTRLCRPRSAPSRCGPGLRPCAPLEDEC-EAPLVCRAGCSPEHGFCEQPGECRCLEG 242
G C L G C DEC AP + C G C C G
Sbjct: 120 GATCRNLADRYECHCPLGYAGVTCEMEVDECASAPCLHGGSCLDGVGSFR----CVCAPG 175
Query: 243 WTGPLCTVPVSTSSCLSPRGPSSATTGCLV-------PGPG-----------PCDGNPCA 284
+ G C + + C S T LV G G C PC
Sbjct: 176 YGGTRCQLDLD--ECQSQPCAHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCE 233
Query: 285 NGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPD---------- 334
+ SC E SF C C G+ G CEV CA PC +GG C+ +DP
Sbjct: 234 HNASCLEGLGSFRCLCWPGYSGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFP 293
Query: 335 --------SAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGP 386
+ ++CHCPPGF+G++C VD C+ +PC NGG C DL + +C C G+AGP
Sbjct: 294 GAFSFRHAAGFLCHCPPGFEGADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGP 353
Query: 387 RCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYA 446
CE D+D+C C +GGTC + + C C +GGRDC + C C C
Sbjct: 354 TCEEDVDECLSDPCLHGGTCSDTVAGYICRCPETWGGRDCSVQLTGCQGHTCPLAATCIP 413
Query: 447 HF-SGL---VCACAPGYMGARC 464
F SG+ VC C PG G C
Sbjct: 414 IFESGVHSYVCHCPPGTHGPFC 435
Score = 162 bits (410), Expect = 8e-40
Identities = 105/343 (30%), Positives = 133/343 (38%), Gaps = 91/343 (26%)
Query: 193 PRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPV 252
P PS C PCAP EC+A C P +P C G LC
Sbjct: 35 PSEPPSACASD--PCAP-GTECQATESGGYTCGPM-----EPRGCATQPCHHGALCV--- 83
Query: 253 STSSCLSPRGPSSATTGCL-VPG-PGP--------CDGNPCANGGSCSETPRSFECTCPR 302
P+GP C VPG GP C PC +G +C +EC CP
Sbjct: 84 -------PQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRYECHCPL 136
Query: 303 GFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPC 362
G+ G+ CE+ CA PC +GG C+ G ++ C C PG+ G+ C+ +D C QPC
Sbjct: 137 GYAGVTCEMEVDECASAPCLHGGSCLDGV---GSFRCVCAPGYGGTRCQLDLDECQSQPC 193
Query: 363 RNGGLCLDLGHALRCRCRA---------------------------------------GF 383
+GG C DL + RC C G+
Sbjct: 194 AHGGTCHDLVNGFRCDCAGTGYEGTHCEREVLECASAPCEHNASCLEGLGSFRCLCWPGY 253
Query: 384 AGPRCEHDLDDCAGRACANGGTCVEG------GGAHR---------------CSCALGFG 422
+G CE D D+CA C +GG C++ GG C C GF
Sbjct: 254 SGELCEVDEDECASSPCQHGGRCLQRSDPALYGGVQAAFPGAFSFRHAAGFLCHCPPGFE 313
Query: 423 GRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
G DC D CA+RPC +GG C +G C C GY G CE
Sbjct: 314 GADCGVEVDECASRPCLNGGHCQDLPNGFQCHCPDGYAGPTCE 356
Score = 110 bits (275), Expect = 4e-24
Identities = 81/259 (31%), Positives = 99/259 (38%), Gaps = 32/259 (12%)
Query: 212 DECEAPLVCRAGCSPEHGFCEQPGECRCL--EGWTGPLCTVPVSTSSCLSPRGPSSATTG 269
D P+ R G + + GF + PG R L E +TG CL
Sbjct: 978 DGAATPVALR-GLASDLGFLQGPGAVRILLAENFTG-----------CLGRVALGGLPLP 1025
Query: 270 CLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVG 329
P PG G E S+ T P G R CA PC + G C
Sbjct: 1026 LARPRPGAAPG--------AREHFASWPGT-PAPILGCR---GAPVCAPSPCLHDGAC-- 1071
Query: 330 GADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE 389
D A+ C C PG++G CE VD C PC G CRC GF GPRC
Sbjct: 1072 -RDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECRCPPGFGGPRCR 1130
Query: 390 HDL--DDCA-GRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYA 446
+ +C+ C +G C G A CSC G G+ C+ PC A PC +GG C A
Sbjct: 1131 LPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRA 1190
Query: 447 HFSGLVCACAPGYMGARCE 465
C C + G CE
Sbjct: 1191 AGGVSECICNARFSGQFCE 1209
Score = 82.4 bits (202), Expect = 1e-15
Identities = 42/117 (35%), Positives = 50/117 (42%), Gaps = 3/117 (2%)
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCS 416
C+ PC + G C DL A C C G+ GPRCE +D C CA G G C
Sbjct: 1060 CAPSPCLHDGACRDLFDAFACACGPGWEGPRCEAHVDPCHSAPCARGRCHTHPDGRFECR 1119
Query: 417 CALGFGGRDCR--ERADPCAAR-PCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHP 470
C GFGG CR + C+ C G C C+C G G RC+ P P
Sbjct: 1120 CPPGFGGPRCRLPVPSKECSLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLP 1176
Score = 65.9 bits (159), Expect = 1e-10
Identities = 45/133 (33%), Positives = 54/133 (40%), Gaps = 23/133 (17%)
Query: 200 CGPGLRP--CAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSC 257
CGPG C D C + R C H + ECRC G+ GP C +PV + C
Sbjct: 1082 CGPGWEGPRCEAHVDPCHSAPCARGRC---HTHPDGRFECRCPPGFGGPRCRLPVPSKEC 1138
Query: 258 L--------SP--RGPSSATTGCLVPGPG--------PCDGNPCANGGSCSETPRSFECT 299
SP G +A CL G PC+ NPC NGG+C EC
Sbjct: 1139 SLNVTCLDGSPCEGGSPAANCSCLEGLAGQRCQVPTLPCEANPCLNGGTCRAAGGVSECI 1198
Query: 300 CPRGFYGLRCEVS 312
C F G CEV+
Sbjct: 1199 CNARFSGQFCEVA 1211
Score = 61.6 bits (148), Expect = 2e-09
Identities = 31/77 (40%), Positives = 34/77 (44%), Gaps = 3/77 (3%)
Query: 395 CAGRACANGGTCVEGGG---AHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGL 451
CA + C +G CV G RC C GF G C D CA+RPC HG C
Sbjct: 71 CATQPCHHGALCVPQGPDPTGFRCYCVPGFQGPRCELDIDECASRPCHHGATCRNLADRY 130
Query: 452 VCACAPGYMGARCEFPV 468
C C GY G CE V
Sbjct: 131 ECHCPLGYAGVTCEMEV 147
Score = 51.2 bits (121), Expect = 3e-06
Identities = 31/91 (34%), Positives = 39/91 (42%), Gaps = 6/91 (6%)
Query: 240 LEGWTGPLCTVPVSTSSCLSPRGPSSA---TTGCLVPGPGPCDGNPCANGGSCSETPRSF 296
L+G P +P+ SS S G + T GC+ C +PC NGG+C T F
Sbjct: 772 LDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCV--SEDMCSPDPCFNGGTCLVTWNDF 829
Query: 297 ECTCPRGFYGLRCEVSGVTCADGPCFNGGLC 327
CTCP F G C + C PC C
Sbjct: 830 HCTCPANFTGPTC-AQQLWCPGQPCLPPATC 859
Score = 50.4 bits (119), Expect = 4e-06
Identities = 24/54 (44%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 355 DRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVE 408
D CS PC NGG CL + C C A F GP C L C G+ C TC E
Sbjct: 809 DMCSPDPCFNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEE 861
Score = 48.1 bits (113), Expect = 2e-05
Identities = 22/50 (44%), Positives = 24/50 (48%), Gaps = 2/50 (4%)
Query: 430 ADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAA 479
A CA PC H G C F CAC PG+ G RCE H D + P A
Sbjct: 1057 APVCAPSPCLHDGACRDLFDAFACACGPGWEGPRCE--AHVDPCHSAPCA 1104
Score = 47.0 bits (110), Expect = 5e-05
Identities = 48/182 (26%), Positives = 62/182 (34%), Gaps = 13/182 (7%)
Query: 345 FQGSNCEKRVDRCSLQ----PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRAC 400
F+G + R+D C L P N +LG AG D C+ C
Sbjct: 763 FRGCLQDLRLDGCHLPFFPLPLDNSSQPSELGGRQSWNLTAGCVSE------DMCSPDPC 816
Query: 401 ANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYM 460
NGGTC+ C+C F G C ++ C +PC C G VC +
Sbjct: 817 FNGGTCLVTWNDFHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEEVPDGFVCVAEATFR 875
Query: 461 -GARCEFPVH-PDGASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRR 518
G F H L R D + +LL A G L +A L R
Sbjct: 876 EGPPAAFSGHNASSGRLLGGLSLAFRTRDSEAWLLRAAAGALEGVWLAVRNGSLAGGVRG 935
Query: 519 GH 520
GH
Sbjct: 936 GH 937
Score = 43.1 bits (100), Expect = 7e-04
Identities = 24/73 (32%), Positives = 33/73 (45%), Gaps = 4/73 (5%)
Query: 311 VSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLD 370
VS C+ PCFNGG C+ + + C CP F G C +++ C QPC C +
Sbjct: 806 VSEDMCSPDPCFNGGTCLVTWND---FHCTCPANFTGPTCAQQL-WCPGQPCLPPATCEE 861
Query: 371 LGHALRCRCRAGF 383
+ C A F
Sbjct: 862 VPDGFVCVAEATF 874
Score = 39.7 bits (91), Expect = 0.008
Identities = 17/43 (39%), Positives = 24/43 (55%), Gaps = 1/43 (2%)
Query: 350 CEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDL 392
CE+R ++C PC +GG C+DL RC C GP C ++
Sbjct: 603 CERR-EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEI 644
Score = 39.3 bits (90), Expect = 0.010
Identities = 78/324 (24%), Positives = 98/324 (30%), Gaps = 62/324 (19%)
Query: 22 PQTRPAGVFELQIHSFGPGPGPGAPRSPC-------SARLPCRLFFRVCLKPGLSEEAAE 74
P P E+ +FG G GAP S L R GL + A
Sbjct: 634 PHRGPTCADEIPAATFGLG---GAPSSASFLLQELPGPNLTVSFLLRTRESAGLLLQFAN 690
Query: 75 SPCALGAALSARGPVYTEQPGAPAPDLP--LPDGLLQVPFRDAWPGTFSFIIETWREELG 132
A + G + E PG+PA LP DGL + P ++LG
Sbjct: 691 DSAAGLTVFLSEGRIRAEVPGSPAVVLPGRWDDGLRHLVMLSFGPDQL--------QDLG 742
Query: 133 DQIGGPAWSLLARVAGRRRLAAGGPWARDIQRAGAWELRFSYRARCEPPAVGTACTRLCR 192
+ V GR A PW R +LR C P +
Sbjct: 743 QHV---------HVGGRLLAADSQPWGGPF-RGCLQDLRLD---GCHLPFFPLPLDNSSQ 789
Query: 193 PRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPV 252
P R L ED C +P C G + CL W CT P
Sbjct: 790 PSELGGRQSWNLTAGCVSEDMC-SPDPCFNGGT-------------CLVTWNDFHCTCPA 835
Query: 253 STSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGF-YGLRCEV 311
+ + GP+ A C G PC +C E P F C F G
Sbjct: 836 NFT------GPTCAQQLW-------CPGQPCLPPATCEEVPDGFVCVAEATFREGPPAAF 882
Query: 312 SGVTCADGPCFNGGLCVGGADPDS 335
SG + G GGL + DS
Sbjct: 883 SGHNASSGRLL-GGLSLAFRTRDS 905
Score = 37.7 bits (86), Expect = 0.030
Identities = 18/54 (33%), Positives = 24/54 (44%), Gaps = 2/54 (3%)
Query: 428 ERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARC--EFPVHPDGASALPAA 479
ER + C PC HGG C ++ C CA + G C E P G P++
Sbjct: 604 ERREQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTCADEIPAATFGLGGAPSS 657
Score = 35.8 bits (81), Expect = 0.11
Identities = 24/68 (35%), Positives = 30/68 (44%), Gaps = 10/68 (14%)
Query: 278 CDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG-PCFNGGLCVGGADPDSA 336
C PC +GGSC + F C C R G TCAD P GL GGA ++
Sbjct: 609 CRPLPCVHGGSCVDLWTHFRCDCARPH-------RGPTCADEIPAATFGL--GGAPSSAS 659
Query: 337 YICHCPPG 344
++ PG
Sbjct: 660 FLLQELPG 667
Score = 30.0 bits (66), Expect = 6.2
Identities = 17/50 (34%), Positives = 21/50 (42%), Gaps = 3/50 (6%)
Query: 393 DDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGG 442
+ C C +GG+CV+ RC CA G C AD A GG
Sbjct: 607 EQCRPLPCVHGGSCVDLWTHFRCDCARPHRGPTC---ADEIPAATFGLGG 653
>gi|122937283 6720455I24Rik homolog [Homo sapiens]
Length = 1413
Score = 160 bits (406), Expect = 2e-39
Identities = 102/337 (30%), Positives = 128/337 (37%), Gaps = 86/337 (25%)
Query: 217 PLVCRAGCSPEHGFCEQPG---ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCL-- 271
P +C +G G C++ G C C +TG C + SC S GP C
Sbjct: 581 PHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIG-KPDSCAS--GPCHNGGTCFHY 637
Query: 272 --------VPG---------PGPCDGNPCANGGSCSETPRSFECTCPRGFYGLR------ 308
PG P PC +PC NGG+C + F C C G+ G R
Sbjct: 638 IGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVD 697
Query: 309 -----------------------------------------CEVSGV-----------TC 316
C+ GV C
Sbjct: 698 CGPPEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDEC 757
Query: 317 ADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALR 376
PC +GG C D + Y+C C G++G++CE D C PCRNGG C +L A
Sbjct: 758 RSQPCLHGGSC---QDRVAGYLCLCSTGYEGAHCELERDECRAHPCRNGGSCRNLPGAYV 814
Query: 377 CRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAAR 436
CRC AGF G CE ++D C C +GG C GGGA+ C C F G C +DPC +
Sbjct: 815 CRCPAGFVGVHCETEVDACDSSPCQHGGRCESGGGAYLCVCPESFFGYHCETVSDPCFSS 874
Query: 437 PCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGA 473
PC G C A C C GY G C + P A
Sbjct: 875 PCGGRGYCLASNGSHSCTCKVGYTGEDCAKELFPPTA 911
Score = 159 bits (403), Expect = 5e-39
Identities = 106/301 (35%), Positives = 121/301 (40%), Gaps = 34/301 (11%)
Query: 188 TRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC---EQPGECRCLEGWT 244
T LC RC G P P C + G C +Q C C EG+
Sbjct: 410 TCLCAEPFKGLRCETGDHP---------VPDACLSAPCHNGGTCVDADQGYVCECPEGFM 460
Query: 245 GPLCT--VPVSTSSCLSPRGPSSATTGCLVP------------GPGPCDGNP-CANGGSC 289
G C VP R + TT C P PC+ N C +GG C
Sbjct: 461 GLDCRERVPDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYC 520
Query: 290 SETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSN 349
E S+ C C S C PCFNGG C D +Y C CP GF G +
Sbjct: 521 MEHGGSYLCVCHTDHNASHSLPS--PCDSDPCFNGGSCDAH---DDSYTCECPRGFHGKH 575
Query: 350 CEK-RVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDL-DDCAGRACANGGTCV 407
CEK R CS PCRNGG C + G C C F G CE D CA C NGGTC
Sbjct: 576 CEKARPHLCSSGPCRNGGTCKEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCF 635
Query: 408 EGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFP 467
G ++C C GF GR C PC PC +GG C + C C GYMG RC+
Sbjct: 636 HYIGKYKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAE 695
Query: 468 V 468
V
Sbjct: 696 V 696
Score = 154 bits (390), Expect = 2e-37
Identities = 77/198 (38%), Positives = 98/198 (49%), Gaps = 11/198 (5%)
Query: 282 PCANGGSCSET----PRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAY 337
PC NGG C + S+ C+C GF G RC + CA PC NGG C G +++
Sbjct: 277 PCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGI---NSF 333
Query: 338 ICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG 397
C CP GF G CE C + C++GG C + C C+AG+ G CE D+DDC+
Sbjct: 334 RCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSP 393
Query: 398 RACANGGTCVEGGGAHRCSCALGFGGRDCRER----ADPCAARPCAHGGRCYAHFSGLVC 453
C NGG+CV+ G + C CA F G C D C + PC +GG C G VC
Sbjct: 394 DPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVC 453
Query: 454 ACAPGYMGARCEFPVHPD 471
C G+MG C V D
Sbjct: 454 ECPEGFMGLDCRERVPDD 471
Score = 145 bits (367), Expect = 8e-35
Identities = 113/389 (29%), Positives = 140/389 (35%), Gaps = 103/389 (26%)
Query: 173 SYRARCEPPAVGTACTRLCRP-----RSAPSRCGPGLRPCAPLEDECEAP-----LVCRA 222
+Y C P G C P SAP G G A CE P L CR
Sbjct: 408 NYTCLCAEPFKGLRCETGDHPVPDACLSAPCHNG-GTCVDADQGYVCECPEGFMGLDCRE 466
Query: 223 GCSPEHGFCEQPGEC--------RCLEGWTGPLCTVPVSTSSC-LSPRGPSSATTGCLVP 273
P+ C G C +C G+ G LC ++ C ++ + P C+
Sbjct: 467 RV-PDDCECRNGGRCLGANTTLCQCPLGFFGLLCEFEITAMPCNMNTQCPDGGY--CMEH 523
Query: 274 G-----------------PGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGV-T 315
G P PCD +PC NGGSC S+ C CPRGF+G CE +
Sbjct: 524 GGSYLCVCHTDHNASHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCEKARPHL 583
Query: 316 CADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE-KRVDRCSLQPCRNGGLCLDLGHA 374
C+ GPC NGG C + Y C CP F G +CE + D C+ PC NGG C
Sbjct: 584 CSSGPCRNGGTC---KEAGGEYHCSCPYRFTGRHCEIGKPDSCASGPCHNGGTCFHYIGK 640
Query: 375 LRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERAD--- 431
+C C GF+G CE C C NGGTC + C C G+ GR C+ D
Sbjct: 641 YKCDCPPGFSGRHCEIAPSPCFRSPCVNGGTCEDRDTDFFCHCQAGYMGRRCQAEVDCGP 700
Query: 432 --------------------------------PCAARPC-AHG----------------- 441
P R C HG
Sbjct: 701 PEEVKHATLRFNGTRLGAVALYACDRGYSLSAPSRIRVCQPHGVWSEPPQCLEIDECRSQ 760
Query: 442 -----GRCYAHFSGLVCACAPGYMGARCE 465
G C +G +C C+ GY GA CE
Sbjct: 761 PCLHGGSCQDRVAGYLCLCSTGYEGAHCE 789
Score = 143 bits (361), Expect = 4e-34
Identities = 91/287 (31%), Positives = 114/287 (39%), Gaps = 64/287 (22%)
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTG-----CLVP----GP------GPCDGN 281
C CL G+TG C + V+ + + + T G C P GP PCD
Sbjct: 297 CSCLSGFTGRRCHLDVNECASQPCQNGGTCTHGINSFRCQCPAGFGGPTCETAQSPCDTK 356
Query: 282 PCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCV------------- 328
C +GG C S C C G+ G CE+ C+ PC NGG CV
Sbjct: 357 ECQHGGQCQVENGSAVCVCQAGYTGAACEMDVDDCSPDPCLNGGSCVDLVGNYTCLCAEP 416
Query: 329 ------------------------GG--ADPDSAYICHCPPGFQGSNCEKRV-DRCSLQP 361
GG D D Y+C CP GF G +C +RV D C
Sbjct: 417 FKGLRCETGDHPVPDACLSAPCHNGGTCVDADQGYVCECPEGFMGLDCRERVPDDCE--- 473
Query: 362 CRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDC---AGRACANGGTCVEGGGAHRCSCA 418
CRNGG CL L C+C GF G CE ++ C +GG C+E GG++ C C
Sbjct: 474 CRNGGRCLGANTTL-CQCPLGFFGLLCEFEITAMPCNMNTQCPDGGYCMEHGGSYLCVCH 532
Query: 419 LGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
PC + PC +GG C AH C C G+ G CE
Sbjct: 533 TDHNA--SHSLPSPCDSDPCFNGGSCDAHDDSYTCECPRGFHGKHCE 577
Score = 132 bits (332), Expect = 9e-31
Identities = 63/168 (37%), Positives = 81/168 (48%), Gaps = 1/168 (0%)
Query: 312 SGVTCADGPCFNGGLCVGGA-DPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLD 370
+ V A PC NGG C+ + +Y C C GF G C V+ C+ QPC+NGG C
Sbjct: 269 TSVCLALRPCLNGGKCIDDCVTGNPSYTCSCLSGFTGRRCHLDVNECASQPCQNGGTCTH 328
Query: 371 LGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERA 430
++ RC+C AGF GP CE C + C +GG C G+ C C G+ G C
Sbjct: 329 GINSFRCQCPAGFGGPTCETAQSPCDTKECQHGGQCQVENGSAVCVCQAGYTGAACEMDV 388
Query: 431 DPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPA 478
D C+ PC +GG C C CA + G RCE HP + L A
Sbjct: 389 DDCSPDPCLNGGSCVDLVGNYTCLCAEPFKGLRCETGDHPVPDACLSA 436
Score = 50.1 bits (118), Expect = 6e-06
Identities = 23/45 (51%), Positives = 26/45 (57%), Gaps = 1/45 (2%)
Query: 394 DCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPC 438
+C+ C NGGTCV G AH C C GF GR C E A +RPC
Sbjct: 1310 NCSENPCQNGGTCVPGADAHSCDCGPGFKGRRC-ELACIKVSRPC 1353
Score = 49.7 bits (117), Expect = 8e-06
Identities = 41/132 (31%), Positives = 56/132 (42%), Gaps = 10/132 (7%)
Query: 236 ECRCLEGWTGPLC-TVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGG--SCSET 292
E R L + P T P S + RG SA G P A+ + E
Sbjct: 1227 ELRLLNDHSAPETPTQPPRFSELVDGRGRVSARFGGSPSKAATVRSQPTASAQLENMEEA 1286
Query: 293 PRSFECTCPRGFYGLRCEVSGV--TCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNC 350
P+ +G + ++ V C++ PC NGG CV GAD A+ C C PGF+G C
Sbjct: 1287 PKRVSLALQLPEHGSK-DIGNVPGNCSENPCQNGGTCVPGAD---AHSCDCGPGFKGRRC 1342
Query: 351 EKRVDRCSLQPC 362
E + S +PC
Sbjct: 1343 ELACIKVS-RPC 1353
Score = 46.6 bits (109), Expect = 6e-05
Identities = 22/64 (34%), Positives = 30/64 (46%), Gaps = 11/64 (17%)
Query: 275 PGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADG-----------PCFN 323
PG C NPC NGG+C + C C GF G RCE++ + + P +
Sbjct: 1308 PGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCELACIKVSRPCTRLFSETKAFPVWE 1367
Query: 324 GGLC 327
GG+C
Sbjct: 1368 GGVC 1371
Score = 41.2 bits (95), Expect = 0.003
Identities = 17/33 (51%), Positives = 19/33 (57%)
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE 389
CS PC+NGG C+ A C C GF G RCE
Sbjct: 1311 CSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
Score = 40.4 bits (93), Expect = 0.005
Identities = 16/44 (36%), Positives = 20/44 (45%)
Query: 422 GGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
G +D C+ PC +GG C C C PG+ G RCE
Sbjct: 1300 GSKDIGNVPGNCSENPCQNGGTCVPGADAHSCDCGPGFKGRRCE 1343
>gi|74136023 delta-like 1 homolog [Homo sapiens]
Length = 383
Score = 159 bits (401), Expect = 9e-39
Identities = 81/219 (36%), Positives = 103/219 (47%), Gaps = 12/219 (5%)
Query: 220 CRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGP-- 277
C C+P++GFCE CRC GW GPLC V++ CL C G
Sbjct: 26 CFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELC 85
Query: 278 ------CDGNPCANGGSC-SETPRSFECTCPRGFYGLRCEVSGVTCA--DGPCFNGGLCV 328
C PCAN G+C S +EC+C G+ G C+ C PC +GG CV
Sbjct: 86 DRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCV 145
Query: 329 GGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRC 388
S C CPPGF G+ CE + C+ PC N G+C D+G RCRC AGF C
Sbjct: 146 DDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTC 205
Query: 389 EHDLDDCAGRACANGGTCVEGGG-AHRCSCALGFGGRDC 426
+ +CA C NGGTC++ ++ C C F G C
Sbjct: 206 SRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTC 244
>gi|188528675 slit homolog 1 [Homo sapiens]
Length = 1534
Score = 159 bits (401), Expect = 9e-39
Identities = 86/249 (34%), Positives = 111/249 (44%), Gaps = 22/249 (8%)
Query: 232 EQPGECRCLEGWTGP-------LCTVPVSTSSCLSPRGPSSATTG-CLVPGPGPCDGNPC 283
++PG RC GP L T P C P P+ A C + C +PC
Sbjct: 886 KEPGIARC----AGPQDMEGKLLLTTPAKKFECQGP--PTLAVQAKCDL-----CLSSPC 934
Query: 284 ANGGSCSETPRS-FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCP 342
N G+C P + C CP G+ G CEVS +C+ GPC NGG C D+ + C CP
Sbjct: 935 QNQGTCHNDPLEVYRCACPSGYKGRDCEVSLDSCSSGPCENGGTCHAQEGEDAPFTCSCP 994
Query: 343 PGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG--RAC 400
GF+G C D C C NGG+C+D C+C + G CE +D C+ C
Sbjct: 995 TGFEGPTCGVNTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPC 1054
Query: 401 ANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYM 460
+ CV RC C G+ G +C E D C C +G +C + C CA GY
Sbjct: 1055 QHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYS 1114
Query: 461 GARCEFPVH 469
G CE P H
Sbjct: 1115 GQLCEIPPH 1123
Score = 155 bits (392), Expect = 1e-37
Identities = 93/296 (31%), Positives = 121/296 (40%), Gaps = 52/296 (17%)
Query: 202 PGLRPCAPLED--------------ECEAP--LVCRAGC-----SPEHGFCEQPGECRCL 240
PG+ CA +D EC+ P L +A C SP C+ G C
Sbjct: 888 PGIARCAGPQDMEGKLLLTTPAKKFECQGPPTLAVQAKCDLCLSSP----CQNQGTCH-- 941
Query: 241 EGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRS---FE 297
P+ C P G + C PC NGG+C F
Sbjct: 942 --------NDPLEVYRCACPSGYKGRDCEVSLDS---CSSGPCENGGTCHAQEGEDAPFT 990
Query: 298 CTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRC 357
C+CP GF G C V+ C D C NGG+CV G Y C CP ++G CE+ VD C
Sbjct: 991 CSCPTGFEGPTCGVNTDDCVDHACANGGVCVDGV---GNYTCQCPLQYEGKACEQLVDLC 1047
Query: 358 S--LQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRC 415
S L PC++ C+ RC C G+AG C + DDC C NG C++ ++ C
Sbjct: 1048 SPDLNPCQHEAQCVGTPDGPRCECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSC 1107
Query: 416 SCALGFGGRDCR------ERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
CA G+ G+ C PC C +G C + VC C PG+ G CE
Sbjct: 1108 LCAEGYSGQLCEIPPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECE 1163
Score = 122 bits (305), Expect = 1e-27
Identities = 73/224 (32%), Positives = 93/224 (41%), Gaps = 27/224 (12%)
Query: 213 ECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLV 272
+CE L CS G CE G C EG P +C P G T G
Sbjct: 960 DCEVSL---DSCSS--GPCENGGTCHAQEGEDAPF--------TCSCPTGFEGPTCGV-- 1004
Query: 273 PGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCAD--GPCFNGGLCVGG 330
C + CANGG C + ++ C CP + G CE C+ PC + CVG
Sbjct: 1005 -NTDDCVDHACANGGVCVDGVGNYTCQCPLQYEGKACEQLVDLCSPDLNPCQHEAQCVGT 1063
Query: 331 ADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE- 389
D C C PG+ G NC + D C C+NG C+D ++ C C G++G CE
Sbjct: 1064 PDGPR---CECMPGYAGDNCSENQDDCRDHRCQNGAQCMDEVNSYSCLCAEGYSGQLCEI 1120
Query: 390 -----HDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRE 428
C G C NG CV+ G C C GFGG +C +
Sbjct: 1121 PPHLPAPKSPCEGTECQNGANCVDQGNRPVCQCLPGFGGPECEK 1164
Score = 62.4 bits (150), Expect = 1e-09
Identities = 60/230 (26%), Positives = 77/230 (33%), Gaps = 46/230 (20%)
Query: 223 GCSP------EHGFCEQ---PGE-CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLV 272
GC P HG C+ PG C C GW G C P
Sbjct: 1338 GCEPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPAD------------------- 1378
Query: 273 PGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGG-- 330
GPC G+ C +G S+ C C G+ G C +G PC G C+ G
Sbjct: 1379 ---GPCHGHKCVHGQCVPLDALSYSCQCQDGYSGALCNQAGALAE--PC-RGLQCLHGHC 1432
Query: 331 -ADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE 389
A C C PGF G CE+ C P R+ + G+A+ C+ + C
Sbjct: 1433 QASGTKGAHCVCDPGFSGELCEQE-SECRGDPVRDFHQ-VQRGYAI-CQTTRPLSWVECR 1489
Query: 390 HDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCA 439
C G+ C G CS F + E+ C CA
Sbjct: 1490 ---GSCPGQGCCQGLRLKRRKFTFECSDGTSFA--EEVEKPTKCGCALCA 1534
Score = 61.2 bits (147), Expect = 3e-09
Identities = 35/115 (30%), Positives = 48/115 (41%), Gaps = 9/115 (7%)
Query: 360 QPCRN----GGLCL-DLGHALRCRCRAGFAGPRCEHDLDD-CAGRACANGGTCVEGGGAH 413
+PCR G+C + C C AG+ G C+ D C G C +G ++
Sbjct: 1340 EPCRKLYCLHGICQPNATPGPMCHCEAGWVGLHCDQPADGPCHGHKCVHGQCVPLDALSY 1399
Query: 414 RCSCALGFGGRDCRER---ADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
C C G+ G C + A+PC C HG + G C C PG+ G CE
Sbjct: 1400 SCQCQDGYSGALCNQAGALAEPCRGLQCLHGHCQASGTKGAHCVCDPGFSGELCE 1454
>gi|11321571 slit homolog 3 [Homo sapiens]
Length = 1523
Score = 157 bits (397), Expect = 3e-38
Identities = 85/262 (32%), Positives = 117/262 (44%), Gaps = 42/262 (16%)
Query: 220 CRAGCSPEHGFCEQ-PGE---CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGP 275
C + +G C Q P E C C + G CTVP++T
Sbjct: 920 CLSSPCKNNGTCTQDPVELYRCACPYSYKGKDCTVPINT--------------------- 958
Query: 276 GPCDGNPCANGGSC--SETPRS-FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD 332
C NPC +GG+C S++ + F C+CP GF G RCE++ C D C N CV G +
Sbjct: 959 --CIQNPCQHGGTCHLSDSHKDGFSCSCPLGFEGQRCEINPDDCEDNDCENNATCVDGIN 1016
Query: 333 PDSAYICHCPPGFQGSNCEKRVDRC--SLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEH 390
Y+C CPP + G C++ +D C L C++ C+ L C C G++G CE
Sbjct: 1017 N---YVCICPPNYTGELCDEVIDHCVPELNLCQHEAKCIPLDKGFSCECVPGYSGKLCET 1073
Query: 391 DLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRE-------RADPCAARPCAHGGR 443
D DDC C +G CV+ + C+C GF G C + PC C +G +
Sbjct: 1074 DNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSGPFCEHPPPMVLLQTSPCDQYECQNGAQ 1133
Query: 444 CYAHFSGLVCACAPGYMGARCE 465
C C C PG+ G RCE
Sbjct: 1134 CIVVQQEPTCRCPPGFAGPRCE 1155
Score = 139 bits (349), Expect = 9e-33
Identities = 74/246 (30%), Positives = 100/246 (40%), Gaps = 20/246 (8%)
Query: 232 EQPGECRCLEGWTGP-------LCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCA 284
++PG RC + P L T P C +GP +V C +PC
Sbjct: 877 KEPGIARC----SSPEPMADRLLLTTPTHRFQC---KGPVDIN---IVAKCNACLSSPCK 926
Query: 285 NGGSCSETP-RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
N G+C++ P + C CP + G C V TC PC +GG C + C CP
Sbjct: 927 NNGTCTQDPVELYRCACPYSYKGKDCTVPINTCIQNPCQHGGTCHLSDSHKDGFSCSCPL 986
Query: 344 GFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG--RACA 401
GF+G CE D C C N C+D + C C + G C+ +D C C
Sbjct: 987 GFEGQRCEINPDDCEDNDCENNATCVDGINNYVCICPPNYTGELCDEVIDHCVPELNLCQ 1046
Query: 402 NGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMG 461
+ C+ C C G+ G+ C D C A C HG +C +G C C G+ G
Sbjct: 1047 HEAKCIPLDKGFSCECVPGYSGKLCETDNDDCVAHKCRHGAQCVDTINGYTCTCPQGFSG 1106
Query: 462 ARCEFP 467
CE P
Sbjct: 1107 PFCEHP 1112
Score = 71.6 bits (174), Expect = 2e-12
Identities = 39/106 (36%), Positives = 56/106 (52%), Gaps = 8/106 (7%)
Query: 366 GLCLDLGH-ALRCRCRAGFAGPRCEHDL-DDCAGRACANGGTCVEGGGAHRCSCALGFGG 423
GLC + ++ C CR G+ GP C+ + D C G C + G CV G ++ C CA G+GG
Sbjct: 1341 GLCRSVEKDSVVCECRPGWTGPLCDQEARDPCLGHRC-HHGKCVATGTSYMCKCAEGYGG 1399
Query: 424 RDC---RERADPCAARPCAHGGRCYAHFSG-LVCACAPGYMGARCE 465
C + A+ C+A C H G+C+ G C C PG+ G C+
Sbjct: 1400 DLCDNKNDSANACSAFKC-HHGQCHISDQGEPYCLCQPGFSGEHCQ 1444
Score = 67.8 bits (164), Expect = 3e-11
Identities = 46/173 (26%), Positives = 63/173 (36%), Gaps = 43/173 (24%)
Query: 190 LCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSP-EHGFCEQPGECRCLEGWTGPLC 248
+C P C + C P + C+ A C P + GF C C+ G++G LC
Sbjct: 1021 ICPPNYTGELCDEVIDHCVPELNLCQH----EAKCIPLDKGF-----SCECVPGYSGKLC 1071
Query: 249 TVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLR 308
C + C +G C +T + CTCP+GF G
Sbjct: 1072 ETDNDD-----------------------CVAHKCRHGAQCVDTINGYTCTCPQGFSGPF 1108
Query: 309 CE-------VSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
CE + C C NG C+ + C CPPGF G CEK +
Sbjct: 1109 CEHPPPMVLLQTSPCDQYECQNGAQCIVVQQEPT---CRCPPGFAGPRCEKLI 1158
Score = 61.6 bits (148), Expect = 2e-09
Identities = 57/221 (25%), Positives = 81/221 (36%), Gaps = 50/221 (22%)
Query: 214 CEAPLVCRAGCSPEHGFCEQPGE----CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTG 269
C++ VC+ HG C + C C GWTGPLC
Sbjct: 1332 CKSCTVCK------HGLCRSVEKDSVVCECRPGWTGPLCDQEAR---------------- 1369
Query: 270 CLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCE---VSGVTCADGPCFNGGL 326
PC G+ C + G C T S+ C C G+ G C+ S C+ C +G
Sbjct: 1370 ------DPCLGHRC-HHGKCVATGTSYMCKCAEGYGGDLCDNKNDSANACSAFKCHHGQC 1422
Query: 327 CVGGADPDSAYICHCPPGFQGSNCEK------RVDRCSLQPCRNGGLCLDLGHALRCRCR 380
+ +D Y C C PGF G +C++ +V R ++ + C CR
Sbjct: 1423 HI--SDQGEPY-CLCQPGFSGEHCQQENPCLGQVVREVIRRQKGYASCATASKVPIMECR 1479
Query: 381 AGFAGPRCEHDLDDCAGR---ACANGGTCVEGGGAH-RCSC 417
G GP+C + C +G + VE H C C
Sbjct: 1480 GG-CGPQCCQPTRSKRRKYVFQCTDGSSFVEEVERHLECGC 1519
Score = 60.8 bits (146), Expect = 3e-09
Identities = 35/113 (30%), Positives = 53/113 (46%), Gaps = 8/113 (7%)
Query: 325 GLCVGGADPDSAYICHCPPGFQGSNCEKRV-DRCSLQPCRNGGLCLDLGHALRCRCRAGF 383
GLC + DS +C C PG+ G C++ D C C + G C+ G + C+C G+
Sbjct: 1341 GLC-RSVEKDSV-VCECRPGWTGPLCDQEARDPCLGHRCHH-GKCVATGTSYMCKCAEGY 1397
Query: 384 AGPRCEHDLDD---CAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPC 433
G C++ D C+ C +G + G C C GF G C++ +PC
Sbjct: 1398 GGDLCDNKNDSANACSAFKCHHGQCHISDQGEPYCLCQPGFSGEHCQQE-NPC 1449
>gi|116235485 delta-notch-like EGF repeat-containing transmembrane
[Homo sapiens]
Length = 737
Score = 155 bits (392), Expect = 1e-37
Identities = 107/355 (30%), Positives = 144/355 (40%), Gaps = 16/355 (4%)
Query: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCE 232
++ CE VGT C + P + +D VC G + E C+
Sbjct: 333 TFSCTCEEQYVGTFCEEYDACQRKPCQNNASCIDANEKQDGSNFTCVCLPGYTGE--LCQ 390
Query: 233 QPGECRCLEGW-TGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSE 291
+ L+ G C +S +C P G + V PC +PC N G+C
Sbjct: 391 SKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSACEEKVD---PCASSPCQNNGTCYV 447
Query: 292 TPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE 351
F C C GF G C CA PC +G G ++Y C C PG+ G CE
Sbjct: 448 DGVHFTCNCSPGFTGPTCAQLIDFCALSPCAHGTCRSVG----TSYKCLCDPGYHGLYCE 503
Query: 352 KRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG 411
+ + C PC N C DL + C C A + G CE D CA +C NG TC G
Sbjct: 504 EEYNECLSAPCLNAATCRDLVNGYECVCLAEYKGTHCELYKDPCANVSCLNGATCDSDGL 563
Query: 412 AHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPD 471
C CA GF G +C + C + PC HGG C +G C C G++GA CE +H
Sbjct: 564 NGTCICAPGFTGEECDIDINECDSNPCHHGGSCLDQPNGYNCHCPHGWVGANCE--IHLQ 621
Query: 472 GASALPAAPPGLRPGDPQRYLLPPALGLLVAAGVAGAALLLVHVRRRGHSQDAGS 526
S A P R+ L +G L A + +L+V + R + GS
Sbjct: 622 WKSGHMAESLTNMP----RHSLYIIIGALCVAFILMLIILIVGICRISRIEYQGS 672
Score = 150 bits (378), Expect = 4e-36
Identities = 73/198 (36%), Positives = 94/198 (47%), Gaps = 6/198 (3%)
Query: 272 VPGPGPCDGNPCANGGSCSETP--RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVG 329
VPG + C+ G C+ P +F CTC + G CE C PC N C+
Sbjct: 308 VPGESHANDLECSGKGKCTTKPSEATFSCTCEEQYVGTFCEEYD-ACQRKPCQNNASCID 366
Query: 330 GADPD--SAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPR 387
+ S + C C PG+ G C+ ++D C L PCRNG C+ C+C G+ G
Sbjct: 367 ANEKQDGSNFTCVCLPGYTGELCQSKIDYCILDPCRNGATCISSLSGFTCQCPEGYFGSA 426
Query: 388 CEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAH 447
CE +D CA C N GTC G C+C+ GF G C + D CA PCAH G C +
Sbjct: 427 CEEKVDPCASSPCQNNGTCYVDGVHFTCNCSPGFTGPTCAQLIDFCALSPCAH-GTCRSV 485
Query: 448 FSGLVCACAPGYMGARCE 465
+ C C PGY G CE
Sbjct: 486 GTSYKCLCDPGYHGLYCE 503
Score = 80.1 bits (196), Expect = 5e-15
Identities = 37/107 (34%), Positives = 47/107 (43%), Gaps = 14/107 (13%)
Query: 260 PRGPSSATTGCLVP--GPGPCDGNPCANGGSCSETPR------------SFECTCPRGFY 305
PRG S A P PGPC PC NGG C+ P + CTCP G
Sbjct: 28 PRGSSLANPVPAAPLSAPGPCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGIS 87
Query: 306 GLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEK 352
G C++ CA PC +G + Y+C C G++G NCE+
Sbjct: 88 GANCQLVADPCASNPCHHGNCSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 64.7 bits (156), Expect = 2e-10
Identities = 31/89 (34%), Positives = 39/89 (43%), Gaps = 12/89 (13%)
Query: 316 CADGPCFNGGLCVGGADPDS---------AYICHCPPGFQGSNCEKRVDRCSLQPCRNGG 366
CA PC NGG+C +PD Y C CP G G+NC+ D C+ PC +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 367 LCLDLGHA---LRCRCRAGFAGPRCEHDL 392
+ C C G+ GP CE L
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQAL 136
Score = 64.3 bits (155), Expect = 3e-10
Identities = 36/102 (35%), Positives = 45/102 (44%), Gaps = 25/102 (24%)
Query: 395 CAGRACANGGTCVE------------GGGAHRCSCALGFGGRDCRERADPCAARPCAHGG 442
CA + C NGG C G + C+C G G +C+ ADPCA+ PC H G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPC-HHG 106
Query: 443 RCYAHFS----GLVCACAPGYMGARCEFPVHPDGASALPAAP 480
C + S G +C C GY G CE ALP+ P
Sbjct: 107 NCSSSSSSSSDGYLCICNEGYEGPNCE--------QALPSLP 140
Score = 50.1 bits (118), Expect = 6e-06
Identities = 27/87 (31%), Positives = 37/87 (42%), Gaps = 15/87 (17%)
Query: 357 CSLQPCRNGGLCL-----DLGH-------ALRCRCRAGFAGPRCEHDLDDCAGRACANG- 403
C+ QPCRNGG+C D H C C AG +G C+ D CA C +G
Sbjct: 48 CAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADPCASNPCHHGN 107
Query: 404 --GTCVEGGGAHRCSCALGFGGRDCRE 428
+ + C C G+ G +C +
Sbjct: 108 CSSSSSSSSDGYLCICNEGYEGPNCEQ 134
Score = 35.4 bits (80), Expect = 0.15
Identities = 18/51 (35%), Positives = 21/51 (41%), Gaps = 12/51 (23%)
Query: 432 PCAARPCAHGGRCY------------AHFSGLVCACAPGYMGARCEFPVHP 470
PCAA+PC +GG C A G C C G GA C+ P
Sbjct: 47 PCAAQPCRNGGVCTSRPEPDPQHPAPAGEPGYSCTCPAGISGANCQLVADP 97
>gi|224451128 eyes shut homolog isoform 1 [Homo sapiens]
Length = 3144
Score = 154 bits (388), Expect = 3e-37
Identities = 91/304 (29%), Positives = 125/304 (41%), Gaps = 27/304 (8%)
Query: 178 CEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCR-------AGCSPE-HG 229
CE C +CRP + S C + C+ + C+ C C PE HG
Sbjct: 905 CEDMVNNFRC--ICRPGFSGSLCEIEINECS--SEPCKNNGTCVDLTNRFFCNCEPEYHG 960
Query: 230 -FCE-QPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGG 287
FCE +C+ C +CL P C + C PC + G
Sbjct: 961 PFCELDVNKCKISPCLDEENCVYRTDGYNCLC--APGYTGINCEI-NLDECLSEPCLHDG 1017
Query: 288 SCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQG 347
C + + C C GF+G CE + C PC +G + + Y C C
Sbjct: 1018 VCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRC----TELINEYPCSCDADGTS 1073
Query: 348 SNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCA-----GRACAN 402
+ C+ +++ C+ PC N G C H C C G+ G CE +D+CA C N
Sbjct: 1074 TQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLN 1133
Query: 403 GGTCVEGGG-AHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMG 461
GG CV+G G C C GF G+ C + C++ PC HG C H +G VC C PG+ G
Sbjct: 1134 GGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSG 1193
Query: 462 ARCE 465
CE
Sbjct: 1194 HHCE 1197
Score = 148 bits (373), Expect = 2e-35
Identities = 99/366 (27%), Positives = 130/366 (35%), Gaps = 100/366 (27%)
Query: 173 SYRARCEPP---AVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCR-------A 222
+Y +C PP G +C LC P RC + C + + CE C+
Sbjct: 702 NYFCQCVPPFKVVDGFSC--LCNPGYVGIRCEQDIDDC--ILNACEHNSTCKDLHLSYQC 757
Query: 223 GCSP--EHGFCEQPGE---------------------CRCLEGWTGPLCTVPVSTSSCLS 259
C E FCEQ C C GWTG C+ ++
Sbjct: 758 VCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINE----- 812
Query: 260 PRGPSSATTGCLVPGPGPCDGNPCANGGSCSET--PRSFECTCPRGFYGLRCEVSGVTC- 316
CD +PC NGG C E+ P F C CP + G C C
Sbjct: 813 ------------------CDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCD 854
Query: 317 -ADGPCFNGGLCVGGADPDSAYICH----------------------------------- 340
PC N C+ D + IC
Sbjct: 855 LLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRC 914
Query: 341 -CPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRA 399
C PGF GS CE ++ CS +PC+N G C+DL + C C + GP CE D++ C
Sbjct: 915 ICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISP 974
Query: 400 CANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGY 459
C + CV + C CA G+ G +C D C + PC H G C + C C G+
Sbjct: 975 CLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGF 1034
Query: 460 MGARCE 465
G CE
Sbjct: 1035 FGTHCE 1040
Score = 140 bits (354), Expect = 2e-33
Identities = 87/326 (26%), Positives = 131/326 (40%), Gaps = 31/326 (9%)
Query: 168 WELRF----SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAG 223
WE F S + P + CT L + G + C+ +EC++ G
Sbjct: 763 WEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDPCMNGG 822
Query: 224 CSPEHGFCEQPGE--CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPC--- 278
E PG+ C C +TG C + L +++T LV C
Sbjct: 823 LCHESTI---PGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICR 879
Query: 279 ---DGN------------PCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFN 323
+G C + G C + +F C C GF G CE+ C+ PC N
Sbjct: 880 EEFEGKNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKN 939
Query: 324 GGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGF 383
G CV D + + C+C P + G CE V++C + PC + C+ C C G+
Sbjct: 940 NGTCV---DLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGY 996
Query: 384 AGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGR 443
G CE +LD+C C + G C++G + C C GF G C A+ C + PC H GR
Sbjct: 997 TGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLH-GR 1055
Query: 444 CYAHFSGLVCACAPGYMGARCEFPVH 469
C + C+C +C+ ++
Sbjct: 1056 CTELINEYPCSCDADGTSTQCKIKIN 1081
Score = 120 bits (300), Expect = 5e-27
Identities = 79/253 (31%), Positives = 107/253 (42%), Gaps = 37/253 (14%)
Query: 190 LCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCT 249
LC P C L C L + C VC G + H C+ C G+ G C
Sbjct: 991 LCAPGYTGINCEINLDEC--LSEPCLHDGVCIDGIN--HYTCD------CKSGFFGTHCE 1040
Query: 250 VPVSTSSCLSPRGPSSATTGCLVPGPGPCDGN----------------PCANGGSCSETP 293
+ + CLS T + P CD + PC N G C ++
Sbjct: 1041 T--NANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSA 1098
Query: 294 RSFECTCPRGFYGLRCEVSGVTCADGP-----CFNGGLCVGGADPDSAYICHCPPGFQGS 348
F C CPRG+ G CE S CA+ C NGG+CV G P + C C PGF G
Sbjct: 1099 HGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDG--PGHTFDCRCLPGFSGQ 1156
Query: 349 NCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVE 408
CE ++ CS PC +G C D + C+C+ G++G CE++L +C +C + C+E
Sbjct: 1157 FCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENEL-ECIPNSCVH-ELCME 1214
Query: 409 GGGAHRCSCALGF 421
C C GF
Sbjct: 1215 NEPGSTCLCTPGF 1227
Score = 97.8 bits (242), Expect = 2e-20
Identities = 76/298 (25%), Positives = 103/298 (34%), Gaps = 51/298 (17%)
Query: 173 SYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECE-APLVCRAGC-SPEHGF 230
+Y C+PP G C L D C P C + +
Sbjct: 197 TYSCHCQPPFSGKYCQEL---------------------DACSFKPCKNNGSCINKRENW 235
Query: 231 CEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCS 290
EQ EC C +TG C+ + G C + C +G +
Sbjct: 236 DEQAYECVCHPPFTGKNCSEII-----------------------GQCQPHVCFHGNCSN 272
Query: 291 ETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNC 350
T SF C C F G CEVS C + G+C + SAY CP G N
Sbjct: 273 ITSNSFICECDEQFSGPFCEVSAKPCVSLLFWKRGICPNSS---SAYTYECPKGSSSQNG 329
Query: 351 EKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGG 410
E V SL PC+NG C+ + + + C C F C+ C N TC +
Sbjct: 330 ETDVSEFSLVPCQNGTDCIKISNDVMCICSPIFTDLLCKSIQTSCESFPLRNNATCKKCE 389
Query: 411 GAHRCSCALGFGGRDCRERADPC--AARPCAHGGRCYAHFSGLVCACAPGYMGARCEF 466
+ CSC GF ++C + D C + C + C+ C PG C F
Sbjct: 390 KDYPCSCISGFTEKNCEKAIDHCKLLSINCLNEEWCFNIIGRFKYVCIPGCTKNPCWF 447
Score = 87.0 bits (214), Expect = 4e-17
Identities = 49/187 (26%), Positives = 76/187 (40%), Gaps = 5/187 (2%)
Query: 283 CANGGSC-SET-PRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGAD--PDSAYI 338
C+ G C SE +++ C C F G C+ C+ PC N G C+ + + AY
Sbjct: 183 CSGHGKCLSEAWSKTYSCHCQPPFSGKYCQELDA-CSFKPCKNNGSCINKRENWDEQAYE 241
Query: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGR 398
C C P F G NC + + +C C +G ++ C C F+GP CE C
Sbjct: 242 CVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNSFICECDEQFSGPFCEVSAKPCVSL 301
Query: 399 ACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPG 458
G C A+ C G ++ + PC +G C + ++C C+P
Sbjct: 302 LFWKRGICPNSSSAYTYECPKGSSSQNGETDVSEFSLVPCQNGTDCIKISNDVMCICSPI 361
Query: 459 YMGARCE 465
+ C+
Sbjct: 362 FTDLLCK 368
Score = 85.5 bits (210), Expect = 1e-16
Identities = 62/220 (28%), Positives = 80/220 (36%), Gaps = 22/220 (10%)
Query: 263 PSSATTGCLVPGPGPCDGNPCANGGSC--SETPRSFECTCPRGFYGLRCEVSGVTCADGP 320
P + C P G + CANG SC E + + C + G + +
Sbjct: 517 PEDNNSSCWFPHEGTKE--ICANGCSCLSEEDSQEYRYLCFLRWAGNMYLENTTDDQENE 574
Query: 321 CFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRC-SLQPCRNGGLCLDLGHALRCRC 379
C + +C D + C C + G C VD C GLCL L H C
Sbjct: 575 CQHEAVC---KDEINRPRCSCSLSYIGRLCVVNVDYCLGNHSISVHGLCLALSHNCNCSG 631
Query: 380 RAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCA 439
+ CE D +DC +C NG T G C GF G C D CA+ PC
Sbjct: 632 LQRYERNICEIDTEDCKSASCKNGTTSTHLRGYFFRKCVPGFKGTQCEIDIDECASHPCK 691
Query: 440 HGGRC--------------YAHFSGLVCACAPGYMGARCE 465
+G C + G C C PGY+G RCE
Sbjct: 692 NGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVGIRCE 731
Score = 62.0 bits (149), Expect = 1e-09
Identities = 38/140 (27%), Positives = 57/140 (40%), Gaps = 11/140 (7%)
Query: 341 CPPGFQGSNCEKRV---DRCSLQPCRNGGLCLD--LGHALRCRCRAGFAGPRCEHDLDDC 395
CP G + + K+ + S + C G CL C C+ F+G C+ +LD C
Sbjct: 159 CPLGLRLNVTVKQQFCQESLSSEFCSGHGKCLSEAWSKTYSCHCQPPFSGKYCQ-ELDAC 217
Query: 396 AGRACANGGTCVE-----GGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSG 450
+ + C N G+C+ A+ C C F G++C E C C HG +
Sbjct: 218 SFKPCKNNGSCINKRENWDEQAYECVCHPPFTGKNCSEIIGQCQPHVCFHGNCSNITSNS 277
Query: 451 LVCACAPGYMGARCEFPVHP 470
+C C + G CE P
Sbjct: 278 FICECDEQFSGPFCEVSAKP 297
Score = 55.8 bits (133), Expect = 1e-07
Identities = 25/77 (32%), Positives = 35/77 (45%), Gaps = 5/77 (6%)
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDC-----AGRACANGGTCVEGGG 411
CSL C NGG C++ G ++ C C G+ G C + C C+ G TC+
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673
Query: 412 AHRCSCALGFGGRDCRE 428
+ C C LG G C +
Sbjct: 2674 GYTCFCPLGTTGIYCEQ 2690
Score = 55.1 bits (131), Expect = 2e-07
Identities = 26/76 (34%), Positives = 33/76 (43%), Gaps = 5/76 (6%)
Query: 395 CAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPC-----AARPCAHGGRCYAHFS 449
C+ C NGGTC+E G + C+C G+ G C E C C+ G C +
Sbjct: 2614 CSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPH 2673
Query: 450 GLVCACAPGYMGARCE 465
G C C G G CE
Sbjct: 2674 GYTCFCPLGTTGIYCE 2689
Score = 54.3 bits (129), Expect = 3e-07
Identities = 29/83 (34%), Positives = 39/83 (46%), Gaps = 8/83 (9%)
Query: 276 GPCDG-----NPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGG 330
G CDG N C NGG C+ +F C C + G C S V+C + C + LC+
Sbjct: 2872 GDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQS-VSCLNNLCLHQSLCI-- 2928
Query: 331 ADPDSAYICHCPPGFQGSNCEKR 353
D +Y C C G+ G CE +
Sbjct: 2929 PDQSFSYSCLCTLGWVGRYCENK 2951
Score = 52.4 bits (124), Expect = 1e-06
Identities = 28/86 (32%), Positives = 40/86 (46%), Gaps = 7/86 (8%)
Query: 270 CLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVG 329
C VP C + C N G+C + C CPR + G C+ + +C + PC NG CV
Sbjct: 2334 CHVPW---CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFA--SCENNPCGNGATCVP 2388
Query: 330 GADPDSAYICHCPPGFQGSNCEKRVD 355
+ D +C CP G G C ++
Sbjct: 2389 KSGTD--IVCLCPYGRSGPLCTDAIN 2412
Score = 51.6 bits (122), Expect = 2e-06
Identities = 25/81 (30%), Positives = 35/81 (43%), Gaps = 2/81 (2%)
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCV-EGGGAHRC 415
C CRNGG C G CRC +AG C + C C + C+ + ++ C
Sbjct: 2879 CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSV-SCLNNLCLHQSLCIPDQSFSYSC 2937
Query: 416 SCALGFGGRDCRERADPCAAR 436
C LG+ GR C + A+
Sbjct: 2938 LCTLGWVGRYCENKTSFSTAK 2958
Score = 51.2 bits (121), Expect = 3e-06
Identities = 26/82 (31%), Positives = 37/82 (45%), Gaps = 8/82 (9%)
Query: 316 CADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQP-----CRNGGLCLD 370
C+ C NGG C+ + ++ C+C G++GS C + V C + C G C+
Sbjct: 2614 CSLMKCGNGGTCI---ESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCIS 2670
Query: 371 LGHALRCRCRAGFAGPRCEHDL 392
L H C C G G CE L
Sbjct: 2671 LPHGYTCFCPLGTTGIYCEQAL 2692
Score = 50.8 bits (120), Expect = 3e-06
Identities = 29/81 (35%), Positives = 35/81 (43%), Gaps = 8/81 (9%)
Query: 277 PCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTC---ADGP--CFNGGLCVGGA 331
PC C NGG+C E+ S C C G+ G C + TC D P C G C+
Sbjct: 2613 PCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCI--- 2669
Query: 332 DPDSAYICHCPPGFQGSNCEK 352
Y C CP G G CE+
Sbjct: 2670 SLPHGYTCFCPLGTTGIYCEQ 2690
Score = 48.5 bits (114), Expect = 2e-05
Identities = 76/355 (21%), Positives = 111/355 (31%), Gaps = 99/355 (27%)
Query: 207 CAPLEDECEA-PLVCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSS 265
C ++ CE+ PL A C CE+ C C+ G+T C + LS
Sbjct: 367 CKSIQTSCESFPLRNNATCKK----CEKDYPCSCISGFTEKNCEKAIDHCKLLS------ 416
Query: 266 ATTGCL----------------VPGPGPCDGNPC------------------ANGGSCSE 291
CL +PG C NPC G C +
Sbjct: 417 --INCLNEEWCFNIIGRFKYVCIPG---CTKNPCWFLKNVYLIHQHLCYCGVTFHGICQD 471
Query: 292 T-PRSFECTCPRGFYGLRCE----------------VSGVTCADGP-------------- 320
P FE GF G E T + P
Sbjct: 472 KGPAQFEYVWQLGFAGSEGEKCQGVIDAYFFLAANCTEDATYVNDPEDNNSSCWFPHEGT 531
Query: 321 ---CFNGGLCVGGADPDS-AYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALR 376
C NG C+ D Y+C + G+ + C++ +C D + R
Sbjct: 532 KEICANGCSCLSEEDSQEYRYLCFLR--WAGNMYLENTTDDQENECQHEAVCKDEINRPR 589
Query: 377 CRCRAGFAGPRCEHDLDDCAGR-ACANGGTCVEGGGAHRCSCA--LGFGGRDCRERADPC 433
C C + G C ++D C G + + G C+ +H C+C+ + C + C
Sbjct: 590 CSCSLSYIGRLCVVNVDYCLGNHSISVHGLCL--ALSHNCNCSGLQRYERNICEIDTEDC 647
Query: 434 AARPCAHGGRCYAHFSGLVCA-CAPGYMGARCEFPV-----HPDGASALPAAPPG 482
+ C +G H G C PG+ G +CE + HP A PG
Sbjct: 648 KSASCKNGTTS-THLRGYFFRKCVPGFKGTQCEIDIDECASHPCKNGATCIDQPG 701
Score = 48.1 bits (113), Expect = 2e-05
Identities = 28/84 (33%), Positives = 34/84 (40%), Gaps = 4/84 (4%)
Query: 347 GSNCEK-RVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGT 405
G N E V C+ CRN G C+ L C C ++G C+ C C NG T
Sbjct: 2328 GKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQ--FASCENNPCGNGAT 2385
Query: 406 CVEGGGAH-RCSCALGFGGRDCRE 428
CV G C C G G C +
Sbjct: 2386 CVPKSGTDIVCLCPYGRSGPLCTD 2409
Score = 45.1 bits (105), Expect = 2e-04
Identities = 26/85 (30%), Positives = 32/85 (37%), Gaps = 21/85 (24%)
Query: 229 GFCEQPGE---CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCAN 285
G C + G C C GW G CT VST C P + C+
Sbjct: 2623 GTCIESGTSVYCNCTTGWKGSFCTETVST--CDPEHDPP----------------HHCSR 2664
Query: 286 GGSCSETPRSFECTCPRGFYGLRCE 310
G +C P + C CP G G+ CE
Sbjct: 2665 GATCISLPHGYTCFCPLGTTGIYCE 2689
Score = 35.8 bits (81), Expect = 0.11
Identities = 22/58 (37%), Positives = 25/58 (43%), Gaps = 7/58 (12%)
Query: 272 VPGPGPCDGNPCANGGSC-----SETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNG 324
V P C + C NGG+C S SF+C CP F G CE P FNG
Sbjct: 2097 VAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFF--PSFNG 2152
Score = 34.7 bits (78), Expect = 0.25
Identities = 12/35 (34%), Positives = 18/35 (51%)
Query: 430 ADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
A PC+ C +GG C + + C C G+ G+ C
Sbjct: 2611 ASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFC 2645
Score = 30.8 bits (68), Expect = 3.6
Identities = 16/41 (39%), Positives = 19/41 (46%), Gaps = 5/41 (12%)
Query: 395 CAGRACANGGTC-----VEGGGAHRCSCALGFGGRDCRERA 430
C C NGGTC G + +C C L F GR C + A
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDA 2143
Score = 30.8 bits (68), Expect = 3.6
Identities = 26/95 (27%), Positives = 30/95 (31%), Gaps = 33/95 (34%)
Query: 220 CRAGCSPEHGFCEQPG---ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPG 276
CR G G C G CRCL W G C VS
Sbjct: 2884 CRNG-----GECTVNGTTFSCRCLPDWAGNTCNQSVS----------------------- 2915
Query: 277 PCDGNPCANGGSC-SETPRSFECTCPRGFYGLRCE 310
C N C + C + S+ C C G+ G CE
Sbjct: 2916 -CLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCE 2949
Score = 30.4 bits (67), Expect = 4.7
Identities = 20/58 (34%), Positives = 25/58 (43%), Gaps = 4/58 (6%)
Query: 316 CADGPCFNGGLC--VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDL 371
C C NGG C + + ++ C CP F G CEK D P NG L+L
Sbjct: 2103 CQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEK--DAGLFFPSFNGNSYLEL 2158
Score = 30.0 bits (66), Expect = 6.2
Identities = 12/34 (35%), Positives = 15/34 (44%)
Query: 433 CAARPCAHGGRCYAHFSGLVCACAPGYMGARCEF 466
CA C + G C + L C C Y G C+F
Sbjct: 2339 CAHHLCRNNGTCISDNENLFCECPRLYSGKLCQF 2372
Score = 29.6 bits (65), Expect = 8.1
Identities = 13/40 (32%), Positives = 17/40 (42%), Gaps = 2/40 (5%)
Query: 425 DCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
DC A C C +GG C + + C C P + G C
Sbjct: 2873 DCDGTA--CGYNTCRNGGECTVNGTTFSCRCLPDWAGNTC 2910
>gi|4759146 slit homolog 2 [Homo sapiens]
Length = 1529
Score = 149 bits (376), Expect = 7e-36
Identities = 76/241 (31%), Positives = 101/241 (41%), Gaps = 38/241 (15%)
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSC---SETP 293
C C G+ G C VP+ C NPC +GG+C
Sbjct: 943 CTCPYGFKGQDCDVPIHA-----------------------CISNPCKHGGTCHLKEGEE 979
Query: 294 RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKR 353
F C C GF G CEV+ C D C N CV G + Y C CPP + G CE++
Sbjct: 980 DGFWCICADGFEGENCEVNVDDCEDNDCENNSTCVDGINN---YTCLCPPEYTGELCEEK 1036
Query: 354 VDRCS--LQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGG 411
+D C+ L PC++ C+ +C C G+ G C+ D DDC C NG C +
Sbjct: 1037 LDFCAQDLNPCQHDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVN 1096
Query: 412 AHRCSCALGFGGRDCR-------ERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARC 464
+ C C G+ G C R PC C +G +C + +C C PGY G +C
Sbjct: 1097 GYTCICPEGYSGLFCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEPICQCLPGYQGEKC 1156
Query: 465 E 465
E
Sbjct: 1157 E 1157
Score = 148 bits (374), Expect = 1e-35
Identities = 82/245 (33%), Positives = 104/245 (42%), Gaps = 20/245 (8%)
Query: 232 EQPGECRCLEGWTGP-------LCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCA 284
++PG RC GP L T P +C +GP ++ PC NPC
Sbjct: 879 KEPGIARC----AGPGEMADKLLLTTPSKKFTC---QGPVDVN---ILAKCNPCLSNPCK 928
Query: 285 NGGSCSETPRSF-ECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
N G+C+ P F CTCP GF G C+V C PC +GG C + + C C
Sbjct: 929 NDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDGFWCICAD 988
Query: 344 GFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAG--RACA 401
GF+G NCE VD C C N C+D + C C + G CE LD CA C
Sbjct: 989 GFEGENCEVNVDDCEDNDCENNSTCVDGINNYTCLCPPEYTGELCEEKLDFCAQDLNPCQ 1048
Query: 402 NGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMG 461
+ C+ +C C G+ G C D C C +G C +G C C GY G
Sbjct: 1049 HDSKCILTPKGFKCDCTPGYVGEHCDIDFDDCQDNKCKNGAHCTDAVNGYTCICPEGYSG 1108
Query: 462 ARCEF 466
CEF
Sbjct: 1109 LFCEF 1113
Score = 67.4 bits (163), Expect = 3e-11
Identities = 49/174 (28%), Positives = 64/174 (36%), Gaps = 41/174 (23%)
Query: 188 TRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWTGPL 247
T LC P C L CA + C+ C +P+ GF +C C G+ G
Sbjct: 1021 TCLCPPEYTGELCEEKLDFCAQDLNPCQHDSKCIL--TPK-GF-----KCDCTPGYVGEH 1072
Query: 248 CTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGL 307
C + C N C NG C++ + C CP G+ GL
Sbjct: 1073 CDIDFDD-----------------------CQDNKCKNGAHCTDAVNGYTCICPEGYSGL 1109
Query: 308 RCEVS-------GVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
CE S C + C NG C+ + IC C PG+QG CEK V
Sbjct: 1110 FCEFSPPMVLPRTSPCDNFDCQNGAQCIVRINEP---ICQCLPGYQGEKCEKLV 1160
Score = 65.5 bits (158), Expect = 1e-10
Identities = 55/228 (24%), Positives = 75/228 (32%), Gaps = 63/228 (27%)
Query: 194 RSAPSRCGPGLRPC-------APLEDECEAPLVCRA--GCSP------EHGFCEQPGE-- 236
R AP + G C + L+D + P+ GC P HG C+ +
Sbjct: 1294 RQAPGQNGTSFHGCIRNLYINSELQDFQKVPMQTGILPGCEPCHKKVCAHGTCQPSSQAG 1353
Query: 237 --CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPR 294
C C EGW GPLC + PC GN C +G
Sbjct: 1354 FTCECQEGWMGPLCDQRTN----------------------DPCLGNKCVHGTCLPINAF 1391
Query: 295 SFECTCPRGFYGLRCE--------VSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQ 346
S+ C C G G+ C+ + C G C GL C C G+
Sbjct: 1392 SYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGL--------GQPYCECSSGYT 1443
Query: 347 GSNCEKRVD------RCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRC 388
G +C++ + R Q + C R CR G AG +C
Sbjct: 1444 GDSCDREISCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
Score = 63.9 bits (154), Expect = 4e-10
Identities = 30/78 (38%), Positives = 37/78 (47%), Gaps = 4/78 (5%)
Query: 395 CAGRACANGGTC-VEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCY---AHFSG 450
C C N GTC + +RC+C GF G+DC C + PC HGG C+ G
Sbjct: 922 CLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIHACISNPCKHGGTCHLKEGEEDG 981
Query: 451 LVCACAPGYMGARCEFPV 468
C CA G+ G CE V
Sbjct: 982 FWCICADGFEGENCEVNV 999
Score = 63.5 bits (153), Expect = 5e-10
Identities = 38/116 (32%), Positives = 50/116 (43%), Gaps = 10/116 (8%)
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD-CAGRACANGGTCVEGGGAHRC 415
C + C +G C C+ G+ GP C+ +D C G C +G ++ C
Sbjct: 1336 CHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCLPINAFSYSC 1395
Query: 416 SCALGFGGRDCRERAD---PCAARPCAHGGRCYAHFSGL---VCACAPGYMGARCE 465
C G GG C E D PC A C H G+C SGL C C+ GY G C+
Sbjct: 1396 KCLEGHGGVLCDEEEDLFNPCQAIKCKH-GKC--RLSGLGQPYCECSSGYTGDSCD 1448
Score = 57.0 bits (136), Expect = 5e-08
Identities = 45/169 (26%), Positives = 63/169 (37%), Gaps = 19/169 (11%)
Query: 271 LVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGG 330
++PG PC CA+G + F C C G+ G C+ + PC G CV G
Sbjct: 1329 ILPGCEPCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQR----TNDPCL-GNKCVHG 1383
Query: 331 AD-PDSA--YICHCPPGFQGSNCEKRVD---RCSLQPCRNGGLCLDLGHALRCRCRAGFA 384
P +A Y C C G G C++ D C C++G L C C +G+
Sbjct: 1384 TCLPINAFSYSCKCLEGHGGVLCDEEEDLFNPCQAIKCKHGKCRLSGLGQPYCECSSGYT 1443
Query: 385 GPRCEHDLDDCAGRACAN-------GGTCVEGGGAHRCSCALGFGGRDC 426
G C+ ++ C G + C R C G G C
Sbjct: 1444 GDSCDREI-SCRGERIRDYYQKQQGYAACQTTKKVSRLECRGGCAGGQC 1491
Score = 43.1 bits (100), Expect = 7e-04
Identities = 24/81 (29%), Positives = 31/81 (38%), Gaps = 5/81 (6%)
Query: 386 PRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERA-DPCAARPCAHGGRC 444
P CE C + CA+G C C G+ G C +R DPC C HG
Sbjct: 1331 PGCE----PCHKKVCAHGTCQPSSQAGFTCECQEGWMGPLCDQRTNDPCLGNKCVHGTCL 1386
Query: 445 YAHFSGLVCACAPGYMGARCE 465
+ C C G+ G C+
Sbjct: 1387 PINAFSYSCKCLEGHGGVLCD 1407
Score = 35.0 bits (79), Expect = 0.19
Identities = 13/42 (30%), Positives = 21/42 (50%), Gaps = 1/42 (2%)
Query: 429 RADPCAARPCAHGGRCYAHFSGLV-CACAPGYMGARCEFPVH 469
+ +PC + PC + G C + C C G+ G C+ P+H
Sbjct: 918 KCNPCLSNPCKNDGTCNSDPVDFYRCTCPYGFKGQDCDVPIH 959
>gi|66346693 FAT tumor suppressor 1 precursor [Homo sapiens]
Length = 4588
Score = 131 bits (330), Expect = 2e-30
Identities = 57/163 (34%), Positives = 84/163 (51%), Gaps = 5/163 (3%)
Query: 269 GCLVPGPGPCDGNPCANGGSCSETPRS-FECTCPRGFYGLRCEVSGVTCADGPCFNGGLC 327
GC + C NPC NGG C+ +P + C C + G CE+S C+ PC GG C
Sbjct: 4008 GCFLTATEDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTC 4067
Query: 328 VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPR 387
V + ++C C + G C+ C +PC+NGG C D C+C +GF G R
Sbjct: 4068 VVD---NGGFVCQCRGLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGER 4123
Query: 388 CEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERA 430
C+ D+D+C+G C +G C G++ C+C+ + GR C + A
Sbjct: 4124 CQSDIDECSGNPCLHGALCENTHGSYHCNCSHEYRGRHCEDAA 4166
Score = 118 bits (295), Expect = 2e-26
Identities = 67/198 (33%), Positives = 85/198 (42%), Gaps = 17/198 (8%)
Query: 316 CADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHAL 375
CA PC NGG+C P Y C C + G++CE V+ CS +PC GG C+
Sbjct: 4017 CASNPCQNGGVC--NPSPAGGYYCKCSALYIGTHCEISVNPCSSKPCLYGGTCVVDNGGF 4074
Query: 376 RCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAA 435
C+CR + G RC+ C C NGGTC + C C GF G C+ D C+
Sbjct: 4075 VCQCRGLYTGQRCQLS-PYCKDEPCKNGGTCFDSLDGAVCQCDSGFRGERCQSDIDECSG 4133
Query: 436 RPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPAAPPGLRPGDPQRYLLPP 495
PC HG C C C+ Y G CE A P P L
Sbjct: 4134 NPCLHGALCENTHGSYHCNCSHEYRGRHCE------------DAAPNQYVSTPWNIGLAE 4181
Query: 496 ALGLLVAAGVAGAALLLV 513
+G++V VAG LL+V
Sbjct: 4182 GIGIVVF--VAGIFLLVV 4197
Score = 38.5 bits (88), Expect = 0.017
Identities = 16/41 (39%), Positives = 23/41 (56%), Gaps = 1/41 (2%)
Query: 431 DPCAARPCAHGGRCY-AHFSGLVCACAPGYMGARCEFPVHP 470
+ CA+ PC +GG C + G C C+ Y+G CE V+P
Sbjct: 4015 EDCASNPCQNGGVCNPSPAGGYYCKCSALYIGTHCEISVNP 4055
Score = 31.6 bits (70), Expect = 2.1
Identities = 19/52 (36%), Positives = 23/52 (44%), Gaps = 7/52 (13%)
Query: 294 RSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADP-DSAYICHCPPG 344
R+ C C G RC C D PC G CV +DP + + C CP G
Sbjct: 3776 RAAVCLCKEG----RCPPVHHGCEDDPCPEGSECV--SDPWEEKHTCVCPSG 3821
Score = 30.0 bits (66), Expect = 6.2
Identities = 11/31 (35%), Positives = 14/31 (45%), Gaps = 2/31 (6%)
Query: 278 CDGNPCANGGSCSETP--RSFECTCPRGFYG 306
C+ +PC G C P C CP G +G
Sbjct: 3794 CEDDPCPEGSECVSDPWEEKHTCVCPSGRFG 3824
>gi|46397353 Notch homolog 2 N-terminal like protein [Homo sapiens]
Length = 236
Score = 128 bits (322), Expect = 1e-29
Identities = 72/215 (33%), Positives = 92/215 (42%), Gaps = 32/215 (14%)
Query: 235 GECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPR 294
G C+C EG+ G C PC+ N C NGG+C
Sbjct: 10 GYCKCPEGFLGEYCQ------------------------HRDPCEKNRCQNGGTCVAQAM 45
Query: 295 --SFECTCPRGFYGLRCEVS-GVTC-ADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNC 350
C C GF G C+ S C PC NGG C Y C C GF G C
Sbjct: 46 LGKATCRCASGFTGEDCQYSTSHPCFVSRPCLNGGTC--HMLSRDTYECTCQVGFTGKEC 103
Query: 351 EKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDC-AGRACANGGTCVEG 409
+ D C PC NG C + + C+C GF G +CE D+++C C +GGTC+
Sbjct: 104 QW-TDACLSHPCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNL 162
Query: 410 GGAHRCSCALGFGGRDCRERADPCAARPCAHGGRC 444
G+++C C GF G+ C PCA PC +GG C
Sbjct: 163 PGSYQCQCLQGFTGQYCDSLYVPCAPSPCVNGGTC 197
Score = 108 bits (271), Expect = 1e-23
Identities = 61/172 (35%), Positives = 72/172 (41%), Gaps = 7/172 (4%)
Query: 298 CTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRVDR- 356
C CP GF G C+ C C NGG CV A A C C GF G +C+
Sbjct: 12 CKCPEGFLGEYCQHRD-PCEKNRCQNGGTCVAQAMLGKA-TCRCASGFTGEDCQYSTSHP 69
Query: 357 CSL-QPCRNGGLCLDLGH-ALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHR 414
C + +PC NGG C L C C+ GF G C+ D C CANG TC
Sbjct: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKECQWT-DACLSHPCANGSTCTTVANQFS 128
Query: 415 CSCALGFGGRDCRERADPC-AARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
C C GF G+ C + C C HGG C C C G+ G C+
Sbjct: 129 CKCLTGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCLQGFTGQYCD 180
Score = 102 bits (253), Expect = 1e-21
Identities = 52/137 (37%), Positives = 71/137 (51%), Gaps = 9/137 (6%)
Query: 339 CHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLD---LGHALRCRCRAGFAGPRCEHDLDD- 394
C CP GF G C+ R D C C+NGG C+ LG A CRC +GF G C++
Sbjct: 12 CKCPEGFLGEYCQHR-DPCEKNRCQNGGTCVAQAMLGKAT-CRCASGFTGEDCQYSTSHP 69
Query: 395 -CAGRACANGGTC-VEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV 452
R C NGGTC + + C+C +GF G++C + D C + PCA+G C +
Sbjct: 70 CFVSRPCLNGGTCHMLSRDTYECTCQVGFTGKEC-QWTDACLSHPCANGSTCTTVANQFS 128
Query: 453 CACAPGYMGARCEFPVH 469
C C G+ G +CE V+
Sbjct: 129 CKCLTGFTGQKCETDVN 145
Score = 66.6 bits (161), Expect = 6e-11
Identities = 36/107 (33%), Positives = 48/107 (44%), Gaps = 24/107 (22%)
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSF 296
C+CL G+TG C V+ C +PG C +GG+C P S+
Sbjct: 129 CKCLTGFTGQKCETDVNE---------------CDIPGH-------CQHGGTCLNLPGSY 166
Query: 297 ECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
+C C +GF G C+ V CA PC NGG C D + C+C P
Sbjct: 167 QCQCLQGFTGQYCDSLYVPCAPSPCVNGGTC--RQTGDFTFECNCLP 211
Score = 49.7 bits (117), Expect = 8e-06
Identities = 37/125 (29%), Positives = 51/125 (40%), Gaps = 32/125 (25%)
Query: 180 PPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFC-EQPG--E 236
P A G+ CT + S G + C +EC+ P C+ G G C PG +
Sbjct: 113 PCANGSTCTTVANQFSCKCLTGFTGQKCETDVNECDIPGHCQHG-----GTCLNLPGSYQ 167
Query: 237 CRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSET-PRS 295
C+CL+G+TG C PC +PC NGG+C +T +
Sbjct: 168 CQCLQGFTGQYCDSLYV-----------------------PCAPSPCVNGGTCRQTGDFT 204
Query: 296 FECTC 300
FEC C
Sbjct: 205 FECNC 209
>gi|165932370 FAT tumor suppressor homolog 4 [Homo sapiens]
Length = 4981
Score = 123 bits (309), Expect = 4e-28
Identities = 56/170 (32%), Positives = 74/170 (43%), Gaps = 19/170 (11%)
Query: 315 TCADGPCFNGGLC-------------------VGGADPDSAYICHCPPGFQGSNCEKRVD 355
+C GPC NGG C + +P ++C C PG+ GS CE +D
Sbjct: 3805 SCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDID 3864
Query: 356 RCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRC 415
C PC +GG C +L C C GF G CE D+++C C NG C G+ C
Sbjct: 3865 ECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSFNC 3924
Query: 416 SCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
C G+ G+ C + C PC +GG C + C C G G CE
Sbjct: 3925 VCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHCE 3974
Score = 117 bits (293), Expect = 3e-26
Identities = 57/174 (32%), Positives = 78/174 (44%), Gaps = 31/174 (17%)
Query: 278 CDGNPCANGGSC----------------------SETPRSFECTCPRGFYGLRCEVSGVT 315
C PC NGGSC +E + F C C G+ G CE+
Sbjct: 3806 CVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDIDE 3865
Query: 316 CADGPCFNGGLC---VGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLG 372
C PC +GG C VGG + C CP GF G CE+ ++ C PC+NG +C +
Sbjct: 3866 CLPSPCHSGGTCHNLVGG------FSCSCPDGFTGRACERDINECLQSPCKNGAICQNFP 3919
Query: 373 HALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDC 426
+ C C+ G+ G CE ++ C C NGG+C G ++ C C G G+ C
Sbjct: 3920 GSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYCHCPFGVFGKHC 3973
Score = 89.0 bits (219), Expect = 1e-17
Identities = 50/136 (36%), Positives = 58/136 (42%), Gaps = 22/136 (16%)
Query: 233 QPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPG-----------------P 275
QP C+CL G+ G C + + CL S T LV G
Sbjct: 3844 QPFLCKCLPGYAGSWCEIDID--ECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDI 3901
Query: 276 GPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDS 335
C +PC NG C P SF C C G+ G CE S C PCFNGG C G D
Sbjct: 3902 NECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVD--- 3958
Query: 336 AYICHCPPGFQGSNCE 351
+Y CHCP G G +CE
Sbjct: 3959 SYYCHCPFGVFGKHCE 3974
Score = 88.2 bits (217), Expect = 2e-17
Identities = 47/137 (34%), Positives = 58/137 (42%), Gaps = 22/137 (16%)
Query: 355 DRCSLQPCRNGGLCLD---LGHALR-------------------CRCRAGFAGPRCEHDL 392
D C PC+NGG CL + L+ C+C G+AG CE D+
Sbjct: 3804 DSCVHGPCQNGGSCLRRLAVSSVLKSRESLPVIIVANEPLQPFLCKCLPGYAGSWCEIDI 3863
Query: 393 DDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLV 452
D+C C +GGTC G CSC GF GR C + C PC +G C
Sbjct: 3864 DECLPSPCHSGGTCHNLVGGFSCSCPDGFTGRACERDINECLQSPCKNGAICQNFPGSFN 3923
Query: 453 CACAPGYMGARCEFPVH 469
C C GY G CE V+
Sbjct: 3924 CVCKTGYTGKMCESSVN 3940
Score = 51.2 bits (121), Expect = 3e-06
Identities = 39/134 (29%), Positives = 54/134 (40%), Gaps = 26/134 (19%)
Query: 199 RCGPGLRP--CAPLEDECEAPLVCRAGCSPEH---GFCEQPGECRCLEGWTGPLCTVPVS 253
+C PG C DEC P C +G + + GF C C +G+TG C ++
Sbjct: 3849 KCLPGYAGSWCEIDIDEC-LPSPCHSGGTCHNLVGGF-----SCSCPDGFTGRACERDIN 3902
Query: 254 T-------SSCLSPRGPSSATTGCLVPGPGP--------CDGNPCANGGSCSETPRSFEC 298
+ + P S C G C+ NPC NGGSC S+ C
Sbjct: 3903 ECLQSPCKNGAICQNFPGSFNCVCKTGYTGKMCESSVNYCECNPCFNGGSCQSGVDSYYC 3962
Query: 299 TCPRGFYGLRCEVS 312
CP G +G CE++
Sbjct: 3963 HCPFGVFGKHCELN 3976
Score = 49.7 bits (117), Expect = 8e-06
Identities = 35/104 (33%), Positives = 39/104 (37%), Gaps = 17/104 (16%)
Query: 265 SATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNG 324
S GC GP C NPC + C +Y RC G CA PC NG
Sbjct: 4393 SVKIGCR--GPNICASNPCWG-----------DLLCINQWYAYRCVPPG-DCASHPCQNG 4438
Query: 325 GLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLC 368
G C G S + C CP G CE V C C G +C
Sbjct: 4439 GSCEPGL--HSGFTCSCPDSHTGRTCE-MVVACLGVLCPQGKVC 4479
Score = 47.8 bits (112), Expect = 3e-05
Identities = 25/66 (37%), Positives = 33/66 (50%), Gaps = 4/66 (6%)
Query: 275 PGPCDGNPCANGGSCSETPRS-FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADP 333
PG C +PC NGGSC S F C+CP G CE+ V C C G +C G+
Sbjct: 4427 PGDCASHPCQNGGSCEPGLHSGFTCSCPDSHTGRTCEMV-VACLGVLCPQGKVCKAGS-- 4483
Query: 334 DSAYIC 339
+ ++C
Sbjct: 4484 PAGHVC 4489
Score = 45.8 bits (107), Expect = 1e-04
Identities = 34/104 (32%), Positives = 41/104 (39%), Gaps = 15/104 (14%)
Query: 357 CSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEG-GGAHRC 415
C+ PC LC++ +A RC P DCA C NGG+C G C
Sbjct: 4404 CASNPCWGDLLCINQWYAYRC------VPP------GDCASHPCQNGGSCEPGLHSGFTC 4451
Query: 416 SCALGFGGRDCRERADPCAARPCAHGGRCYAHF-SGLVCACAPG 458
SC GR C E C C G C A +G VC + G
Sbjct: 4452 SCPDSHTGRTC-EMVVACLGVLCPQGKVCKAGSPAGHVCVLSQG 4494
Score = 43.5 bits (101), Expect = 5e-04
Identities = 20/51 (39%), Positives = 23/51 (45%)
Query: 426 CRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASAL 476
C C PC HGG C ++S C C G G CE V PD A +L
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSL 4209
Score = 40.0 bits (92), Expect = 0.006
Identities = 14/40 (35%), Positives = 21/40 (52%)
Query: 350 CEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCE 389
C + C+ PC++GG C+D +C C+ G G CE
Sbjct: 4159 CPRLEGACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCE 4198
Score = 38.9 bits (89), Expect = 0.013
Identities = 26/95 (27%), Positives = 33/95 (34%), Gaps = 19/95 (20%)
Query: 395 CAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHF-SGLVC 453
CA C C+ A+RC CA+ PC +GG C SG C
Sbjct: 4404 CASNPCWGDLLCINQWYAYRCV------------PPGDCASHPCQNGGSCEPGLHSGFTC 4451
Query: 454 ACAPGYMGARCEFPVH------PDGASALPAAPPG 482
+C + G CE V P G +P G
Sbjct: 4452 SCPDSHTGRTCEMVVACLGVLCPQGKVCKAGSPAG 4486
Score = 36.2 bits (82), Expect = 0.086
Identities = 17/55 (30%), Positives = 23/55 (41%)
Query: 395 CAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFS 449
C C +GGTC++ +C C G G+ C + P A GR H S
Sbjct: 4166 CTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKSVTPDTALSLEGKGRLDYHMS 4220
Score = 35.0 bits (79), Expect = 0.19
Identities = 17/39 (43%), Positives = 19/39 (48%), Gaps = 3/39 (7%)
Query: 316 CADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV 354
C PC +GG C+ D S CHC G G CEK V
Sbjct: 4166 CTRSPCQHGGTCM---DYWSWQQCHCKEGLTGKYCEKSV 4201
Score = 34.3 bits (77), Expect = 0.33
Identities = 14/37 (37%), Positives = 19/37 (51%)
Query: 276 GPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVS 312
G C +PC +GG+C + +C C G G CE S
Sbjct: 4164 GACTRSPCQHGGTCMDYWSWQQCHCKEGLTGKYCEKS 4200
>gi|209571555 von Willebrand factor D and EGF domains [Homo sapiens]
Length = 1590
Score = 123 bits (308), Expect = 5e-28
Identities = 97/305 (31%), Positives = 121/305 (39%), Gaps = 45/305 (14%)
Query: 175 RARCEPPAVGTACTRLCRPRSAPSRC-GPGLRPCAP--LEDECEAPLVCRAGCSPEHGFC 231
R R P G A T P C P + C P + C+ L C C HG C
Sbjct: 1283 RKRHVKPTSGNAFTICKYPCGKSRECVAPNICKCKPGYIGSNCQTAL-CDPDCK-NHGKC 1340
Query: 232 EQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVP----GPGPCD----GNPC 283
+P C+CL G G C C G A C P GP C+ C
Sbjct: 1341 IKPNICQCLPGHGGATCDEEHCNPPC-QHGGTCLAGNLCTCPYGFVGPR-CETMVCNRHC 1398
Query: 284 ANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPP 343
NGG C TP C C G+YG C + D C NGG C + C CP
Sbjct: 1399 ENGGQCL-TPDI--CQCKPGWYGPTCSTA---LCDPVCLNGGSC------NKPNTCLCPN 1446
Query: 344 GFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANG 403
GF G +C+ PC+NGG C+ C CR G+ G R + + D C NG
Sbjct: 1447 GFFGEHCQNAFCH---PPCKNGGHCMRNNV---CVCREGYTGRRFQKSICD---PTCMNG 1497
Query: 404 GTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGAR 463
G CV G CSC G+ G+ C P + C +GG C A +C C + G R
Sbjct: 1498 GKCV---GPSTCSCPSGWSGKRCNT---PICLQKCKNGGECIAPS---ICHCPSSWEGVR 1548
Query: 464 CEFPV 468
C+ P+
Sbjct: 1549 CQIPI 1553
Score = 80.9 bits (198), Expect = 3e-15
Identities = 68/233 (29%), Positives = 87/233 (37%), Gaps = 68/233 (29%)
Query: 278 CDGNPCANGGSCSE----TPRS--FECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGA 331
CD C NGGSC +P S + C C GF+G CEV C PC G G
Sbjct: 1181 CD---CLNGGSCVSDRNFSPGSGVYLCVCLPGFHGSLCEVDISGCQSNPCGLGSYISG-- 1235
Query: 332 DPDSAYICHCPPGFQ-------------------GSNCEKRVDRCSLQ------------ 360
+Y C CPP + + K D + Q
Sbjct: 1236 --FHSYSCDCPPELKVETQFVNQFTTQTVVLTRSDKSVNKEEDDKNAQGRKRHVKPTSGN 1293
Query: 361 -------PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDDCAGRACANGGTCVEGGGAH 413
PC C+ C+C+ G+ G C+ L D C N G C++ +
Sbjct: 1294 AFTICKYPCGKSRECVAPN---ICKCKPGYIGSNCQTALCD---PDCKNHGKCIK---PN 1344
Query: 414 RCSCALGFGGRDC-RERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
C C G GG C E +P PC HGG C A G +C C G++G RCE
Sbjct: 1345 ICQCLPGHGGATCDEEHCNP----PCQHGGTCLA---GNLCTCPYGFVGPRCE 1390
Score = 54.3 bits (129), Expect = 3e-07
Identities = 39/149 (26%), Positives = 51/149 (34%), Gaps = 51/149 (34%)
Query: 219 VCRAG----------CSP---EHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSS 265
VCR G C P G C P C C GW+G C P+ CL
Sbjct: 1475 VCREGYTGRRFQKSICDPTCMNGGKCVGPSTCSCPSGWSGKRCNTPI----CL------- 1523
Query: 266 ATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGG 325
C NGG C C CP + G+RC+ + + C GG
Sbjct: 1524 ---------------QKCKNGGECIAPS---ICHCPSSWEGVRCQ---IPICNPKCLYGG 1562
Query: 326 LCVGGADPDSAYICHCPPGFQGSNCEKRV 354
C+ +C C + G CEK++
Sbjct: 1563 RCI------FPNVCSCRTEYSGVKCEKKI 1585
>gi|14192943 multiple EGF-like-domains 10 [Homo sapiens]
Length = 1140
Score = 118 bits (295), Expect = 2e-26
Identities = 94/306 (30%), Positives = 127/306 (41%), Gaps = 70/306 (22%)
Query: 198 SRCGPGLRPCAPLEDECEAPLVCRAGCSPE--HGFCEQPGECRCLEGWTGPLCTVPVSTS 255
S+C PG E+ +C C+ + HG C P C+C GW G C +S
Sbjct: 92 SQCCPGFY---------ESGEMCVPHCADKCVHGRCIAPNTCQCEPGWGGTNC-----SS 137
Query: 256 SCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVT 315
+C T+ C C NG C+ P + C C GF G RCE
Sbjct: 138 ACDGDHWGPHCTSRC-----------QCKNGALCN--PITGACHCAAGFRGWRCE---DR 181
Query: 316 CADG----PCFNGGLCVGGADPDSAY-ICHCPPGFQGSNCE------KRVDRCSLQ-PCR 363
C G C C GA D C CPPG+ G+ CE K +C + PC+
Sbjct: 182 CEQGTYGNDCHQRCQCQNGATCDHVTGECRCPPGYTGAFCEDLCPPGKHGPQCEQRCPCQ 241
Query: 364 NGGLCLDLGHALRCRCRAGFAGPRCEHDLDD------CAGRA-CANGGTCVEGGGAHRCS 416
NGG+C + C C +G+ G C + C+ C NGGTC G +C
Sbjct: 242 NGGVCHHV--TGECSCPSGWMGTVCGQPCPEGRFGKNCSQECQCHNGGTCDAATG--QCH 297
Query: 417 CALGFGGRDCRER----------ADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEF 466
C+ G+ G C++ A+ C C +GG+CY H SG C C G+ G RCE
Sbjct: 298 CSPGYTGERCQDECPVGTYGVLCAETC---QCVNGGKCY-HVSG-ACLCEAGFAGERCEA 352
Query: 467 PVHPDG 472
+ P+G
Sbjct: 353 RLCPEG 358
Score = 100 bits (249), Expect = 4e-21
Identities = 104/345 (30%), Positives = 129/345 (37%), Gaps = 90/345 (26%)
Query: 165 AGAWELRFSYRARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAP------- 217
+G W + +C G AC L C PG R ++CE P
Sbjct: 488 SGTWGFGCNLTCQC---LNGGACNTL----DGTCTCAPGWRG-----EKCELPCQDGTYG 535
Query: 218 LVC--RAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPR-GPSSATTGCLVPG 274
L C R CS G G CRCL GW+G C S C R GP+ +
Sbjct: 536 LNCAERCDCSHADGCHPTTGHCRCLPGWSGVHC-----DSVCAEGRWGPNCSL------- 583
Query: 275 PGPCDGNPCANGGSCSETPRSFEC-------TCPR----GFYGLRCEVSGVTC--ADGPC 321
PC C NG SCS EC TC R GFYG RC + C + GPC
Sbjct: 584 --PC---YCKNGASCSPDDGICECAPGFRGTTCQRICSPGFYGHRCSQTCPQCVHSSGPC 638
Query: 322 FN-GGLCVGGADPDSAYICH--CPPGFQGSNCEKRVDRCSLQPCRNGGLCLDLGHALRCR 378
+ GLC + +C+ CP G G NC + C N G C + + C+
Sbjct: 639 HHITGLC-DCLPGFTGALCNEVCPSGRFGKNC------AGICTCTNNGTCNPIDRS--CQ 689
Query: 379 CRAGFAGPRCE------HDLDDCAGRA-CANGGTCVEGGGAHRCS-----------CALG 420
C G+ G C H +C C NG C G +C+ C LG
Sbjct: 690 CYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGAFCSAYDGECKCTPGWTGLYCTQRCPLG 749
Query: 421 FGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCE 465
F G+DC C +G C H SG C C G+MG CE
Sbjct: 750 FYGKDC------ALICQCQNGADC-DHISG-QCTCRTGFMGRHCE 786
Score = 99.4 bits (246), Expect = 8e-21
Identities = 100/373 (26%), Positives = 127/373 (34%), Gaps = 114/373 (30%)
Query: 177 RCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVCRAGCSPEHGFCEQ-PG 235
RC P G C LC P + GP +CE C+ G G C G
Sbjct: 211 RCPPGYTGAFCEDLC----PPGKHGP----------QCEQRCPCQNG-----GVCHHVTG 251
Query: 236 ECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRS 295
EC C GW G +C P C R + + C C NGG+C +
Sbjct: 252 ECSCPSGWMGTVCGQP-----CPEGRFGKNCSQEC-----------QCHNGGTCDAA--T 293
Query: 296 FECTCPRGFYGLRCE------VSGVTCADG-PCFNGG---------LCVGGADPDSAYIC 339
+C C G+ G RC+ GV CA+ C NGG LC G +
Sbjct: 294 GQCHCSPGYTGERCQDECPVGTYGVLCAETCQCVNGGKCYHVSGACLCEAGFAGERCEAR 353
Query: 340 HCPPGFQGSNCEKRVD--------------RCSLQP------------------------ 361
CP G G C+KR C+ +P
Sbjct: 354 LCPEGLYGIKCDKRCPCHLENTHSCHPMSGECACKPGWSGLYCNETCSPGFYGEACQQIC 413
Query: 362 -CRNGGLCLDLGHALRCRCRAGFAGPRCEHDLD------DCAGRA-CANGGTCVEGGGAH 413
C+NG C + +C C GF G C +C+ R C N C G+
Sbjct: 414 SCQNGADCDSVTG--KCTCAPGFKGIDCSTPCPLGTYGINCSSRCGCKNDAVCSPVDGS- 470
Query: 414 RCSCALGFGGRDCRERADPCA-------ARPCAHGGRCYAHFSGLVCACAPGYMGARCEF 466
C+C G+ G DC R C +GG C G C CAPG+ G +CE
Sbjct: 471 -CTCKAGWHGVDCSIRCPSGTWGFGCNLTCQCLNGGACNT-LDG-TCTCAPGWRGEKCEL 527
Query: 467 PVHPDGASALPAA 479
P DG L A
Sbjct: 528 PCQ-DGTYGLNCA 539
Score = 85.1 bits (209), Expect = 2e-16
Identities = 92/341 (26%), Positives = 122/341 (35%), Gaps = 83/341 (24%)
Query: 178 CEPPAVGTACTRLCRPRSAPS--------RCGPGLRPCAPLEDECEAP-------LVC-- 220
C P G AC ++C ++ C PG + +C P + C
Sbjct: 400 CSPGFYGEACQQICSCQNGADCDSVTGKCTCAPGFKGI-----DCSTPCPLGTYGINCSS 454
Query: 221 RAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATT-GCLVPGPGPCD 279
R GC + G C C GW G C++ R PS GC + C
Sbjct: 455 RCGCKNDAVCSPVDGSCTCKAGWHGVDCSI----------RCPSGTWGFGCNLT----CQ 500
Query: 280 GNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGP----CFNGGLC--VGGADP 333
C NGG+C+ + CTC G+ G +CE+ C DG C C G P
Sbjct: 501 ---CLNGGACNTLDGT--CTCAPGWRGEKCELP---CQDGTYGLNCAERCDCSHADGCHP 552
Query: 334 DSAYICHCPPGFQGSNCEKRV------DRCSLQP-CRNGGLCL-DLGHALRCRCRAGFAG 385
+ + C C PG+ G +C+ CSL C+NG C D G C C GF G
Sbjct: 553 TTGH-CRCLPGWSGVHCDSVCAEGRWGPNCSLPCYCKNGASCSPDDGI---CECAPGFRG 608
Query: 386 PRCE---------HDLDDCAGRACANGGTCVEGGGAHRCSCALGFGGRDCRERADP---- 432
C+ H + + G C G C C GF G C E
Sbjct: 609 TTCQRICSPGFYGHRCSQTCPQCVHSSGPCHHITGL--CDCLPGFTGALCNEVCPSGRFG 666
Query: 433 --CAAR-PCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHP 470
CA C + G C C C PG++G+ C P P
Sbjct: 667 KNCAGICTCTNNGTCNPIDRS--CQCYPGWIGSDCSQPCPP 705
Score = 57.8 bits (138), Expect = 3e-08
Identities = 50/181 (27%), Positives = 61/181 (33%), Gaps = 50/181 (27%)
Query: 191 CRPRSAPSRCGPGL------RPCAPLE--DECEAPLVCRAGCSPEHGFCEQ-PGECRCLE 241
C P +C PG +PC P C C G FC GEC+C
Sbjct: 681 CNPIDRSCQCYPGWIGSDCSQPCPPAHWGPNCIHTCNCHNGA-----FCSAYDGECKCTP 735
Query: 242 GWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCP 301
GWTG CT C P G + C NG C S +CTC
Sbjct: 736 GWTGLYCT-----QRC--PLGFYGKDCALICQ---------CQNGADCDHI--SGQCTCR 777
Query: 302 RGFYGLRCEVSGVTCADGP----------CFNGGLCVGGADPDSAYICHCPPGFQGSNCE 351
GF G CE C G C N C C+C PG++G+ C+
Sbjct: 778 TGFMGRHCEQK---CPSGTYGYGCRQICDCLNNSTC-----DHITGTCYCSPGWKGARCD 829
Query: 352 K 352
+
Sbjct: 830 Q 830
>gi|122937343 platelet endothelial aggregation receptor 1 [Homo
sapiens]
Length = 1037
Score = 114 bits (285), Expect = 2e-25
Identities = 102/362 (28%), Positives = 137/362 (37%), Gaps = 94/362 (25%)
Query: 177 RCEPPAVGTACTRLCRPRSAPSRCGPGLR-----PCAPLEDECEAP-------------- 217
+C P G C LC P + C C+P++ EC
Sbjct: 424 QCAPGYTGPHCASLCPPDTYGVNCSARCSCENAIACSPIDGECVCKEGWQRGNCSVPCPP 483
Query: 218 ----LVCRAGCSPEH-GFCE-QPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCL 271
C A C H C Q G C C GW G C +P P+G GC
Sbjct: 484 GTWGFSCNASCQCAHEAVCSPQTGACTCTPGWHGAHCQLP-------CPKGQFG--EGC- 533
Query: 272 VPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVS------GVTCADG-PCFNG 324
CD C + C P C C G+ G RC +S GV C++ C NG
Sbjct: 534 ---ASRCD---CDHSDGCD--PVHGRCQCQAGWMGARCHLSCPEGLWGVNCSNTCTCKNG 585
Query: 325 GLCVGGADPDSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGGLCLD---LGHAL------ 375
G C+ P++ C C PGF+G +C++ S QP R G C+ H+
Sbjct: 586 GTCL----PENGN-CVCAPGFRGPSCQR-----SCQPGRYGKRCVPCKCANHSFCHPSNG 635
Query: 376 RCRCRAGFAGPRCE------HDLDDCAGRA-CANGGTCVEGGGAHRCSCALGFGGRDCRE 428
C C AG+ GP C H ++CA C +GGTC G+ C C LG+ G C E
Sbjct: 636 TCYCLAGWTGPDCSQPCPPGHWGENCAQTCQCHHGGTCHPQDGS--CICPLGWTGHHCLE 693
Query: 429 R----------ADPCAARPCAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPDGASALPA 478
+ PC C G +C+ C C PG+ GA C + + + +P
Sbjct: 694 GCPLGTFGANCSQPC---QCGPGEKCHPETG--ACVCPPGHSGAPCRIGIQ-EPFTVMPT 747
Query: 479 AP 480
P
Sbjct: 748 TP 749
Score = 106 bits (264), Expect = 7e-23
Identities = 103/353 (29%), Positives = 123/353 (34%), Gaps = 86/353 (24%)
Query: 175 RARCEPPAVGTACTRLCRPRSAPSRCGPGLRPCAPLEDECEAPLVC--RAGCSPEHGFCE 232
+ +C P G C+ C AP GP +C+ P C + C P+ G C
Sbjct: 119 QCQCVPGWRGDDCSSEC----APGMWGP----------QCDKPCSCGNNSSCDPKSGVCS 164
Query: 233 -----QPGECR--CLEGWTGPLCTVPVS---------TSSCLSPR---GPS------SAT 267
QP C C G+ GP C T +C P GPS T
Sbjct: 165 CPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPCDPQTGACFCPAERTGPSCDVSCSQGT 224
Query: 268 TGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGP------- 320
+G P + C NGG +TP+ C+CP G+ G C + GP
Sbjct: 225 SGFFCPST-----HSCQNGG-VFQTPQG-SCSCPPGWMGTICSLPCPEGFHGPNCSQECR 277
Query: 321 CFNGGLCVGGADPDSAYICHCPPGFQGSNCEKRV-------DRCSLQPCRNGGLCLDLGH 373
C NGGLC C C PG+ G C + D C C
Sbjct: 278 CHNGGLCDRFTGQ-----CRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDARCFPANG 332
Query: 374 ALRCRCRAGFAGPRCEHDL--DDCAGRACANGGTCVEGGGAH------RCSCALGFGGRD 425
A C C GF G RC L D G +C TC CSC G+ G
Sbjct: 333 A--CLCEHGFTGDRCTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLH 390
Query: 426 CRERADPCAARP-------CAHGGRCYAHFSGLVCACAPGYMGARCEFPVHPD 471
C E P C HGG C A SGL C CAPGY G C PD
Sbjct: 391 CNESCPQDTHGPGCQEHCLCLHGGVCQAT-SGL-CQCAPGYTGPHCASLCPPD 441
Score = 100 bits (249), Expect = 4e-21
Identities = 97/311 (31%), Positives = 117/311 (37%), Gaps = 86/311 (27%)
Query: 220 CRAGCSPE--HGFCEQPGECRCLEGWT-------------GPLCTVPVS---TSSCLSPR 261
C C+ E HG C P +C+C+ GW GP C P S SSC
Sbjct: 101 CVPLCAQECVHGRCVAPNQCQCVPGWRGDDCSSECAPGMWGPQCDKPCSCGNNSSCDPKS 160
Query: 262 GPSSATTG-----CLVP------GPG-----PCDGNPCANGGSCSETPRSFECTCPRGFY 305
G S +G CL P GP C G PC P++ C CP
Sbjct: 161 GVCSCPSGLQPPNCLQPCTPGYYGPACQFRCQCHGAPC--------DPQTGACFCPAERT 212
Query: 306 GLRCEV------SGVTC-ADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCEK------ 352
G C+V SG C + C NGG+ P + C CPPG+ G+ C
Sbjct: 213 GPSCDVSCSQGTSGFFCPSTHSCQNGGVF---QTPQGS--CSCPPGWMGTICSLPCPEGF 267
Query: 353 RVDRCSLQ-PCRNGGLCLDLGHALRCRCRAGFAGPRCEHDL------DDCAGRA-CANGG 404
CS + C NGGLC +CRC G+ G RC + DCA CA
Sbjct: 268 HGPNCSQECRCHNGGLCDRF--TGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDA 325
Query: 405 TCVEGGGAHRCSCALGFGGRDCRERADP-------CAARPCA----HGGRCYAHFSGLVC 453
C GA C C GF G C +R P C A PC H C H C
Sbjct: 326 RCFPANGA--CLCEHGFTGDRCTDRLCPDGFYGLSCQA-PCTCDREHSLSC--HPMNGEC 380
Query: 454 ACAPGYMGARC 464
+C PG+ G C
Sbjct: 381 SCLPGWAGLHC 391
Score = 99.8 bits (247), Expect = 6e-21
Identities = 107/385 (27%), Positives = 135/385 (35%), Gaps = 101/385 (26%)
Query: 171 RFSYRARCEPPAVGTACTRLC------RPRSAPSRCGPGLRPCAPLEDECEAP------- 217
RF+ + RC P G C C + + C P R C P C
Sbjct: 286 RFTGQCRCAPGYTGDRCREECPVGRFGQDCAETCDCAPDAR-CFPANGACLCEHGFTGDR 344
Query: 218 ------------LVCRAGCS--PEHGFCEQP--GECRCLEGWTGPLCTV--------PVS 253
L C+A C+ EH P GEC CL GW G C P
Sbjct: 345 CTDRLCPDGFYGLSCQAPCTCDREHSLSCHPMNGECSCLPGWAGLHCNESCPQDTHGPGC 404
Query: 254 TSSCLSPR-GPSSATTGCLVPGPGPCDGNPCAN-------GGSCSE----------TPRS 295
CL G AT+G PG G CA+ G +CS +P
Sbjct: 405 QEHCLCLHGGVCQATSGLCQCAPG-YTGPHCASLCPPDTYGVNCSARCSCENAIACSPID 463
Query: 296 FECTCPRGFYGLRCEVS------GVTC-ADGPCFNGGLCVGGADPDSAYICHCPPGFQGS 348
EC C G+ C V G +C A C + +C P + C C PG+ G+
Sbjct: 464 GECVCKEGWQRGNCSVPCPPGTWGFSCNASCQCAHEAVC----SPQTG-ACTCTPGWHGA 518
Query: 349 NC----------EKRVDRCSLQPCRNGGLCLDLGHALRCRCRAGFAGPRCEHDLDD---- 394
+C E RC C + C D H RC+C+AG+ G RC +
Sbjct: 519 HCQLPCPKGQFGEGCASRCD---CDHSDGC-DPVHG-RCQCQAGWMGARCHLSCPEGLWG 573
Query: 395 --CAGR-ACANGGTCVEGGGAHRCSCALGFGGRDCRERADP------CAARPCAHGGRCY 445
C+ C NGGTC+ G C CA GF G C+ P C PC +
Sbjct: 574 VNCSNTCTCKNGGTCLPENG--NCVCAPGFRGPSCQRSCQPGRYGKRCV--PCKCANHSF 629
Query: 446 AHFSGLVCACAPGYMGARCEFPVHP 470
H S C C G+ G C P P
Sbjct: 630 CHPSNGTCYCLAGWTGPDCSQPCPP 654
>gi|122937400 odz, odd Oz/ten-m homolog 3 [Homo sapiens]
Length = 2699
Score = 110 bits (276), Expect = 3e-24
Identities = 91/309 (29%), Positives = 115/309 (37%), Gaps = 82/309 (26%)
Query: 187 CTRLCRPRSAPSRCGPGLRPCAP--LEDECEAPLVCRAGCSPEHGFCEQPGECRCLEGWT 244
C R C C G C P L +C C CS + + G C C GW
Sbjct: 518 CPRNCHGNG---ECVSGTCHCFPGFLGPDCSRA-ACPVLCSGNGQYSK--GRCLCFSGWK 571
Query: 245 GPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGPCDGNPCANGGSCSETPRSFECTCPRGF 304
G C VP T+ C+ P+ C G GSC+ C G+
Sbjct: 572 GTECDVP--TTQCIDPQ----------------CGGRGICIMGSCA---------CNSGY 604
Query: 305 YGLRCEVSGVTCADGPCFNGGLCVGGADPDSAYICHCPPGFQGSNCE------------- 351
G CE + C D C N G+C+ G CHC PG+ GSNCE
Sbjct: 605 KGESCEEAD--CIDPGCSNHGVCIHGE-------CHCSPGWGGSNCEILKTMCPDQCSGH 655
Query: 352 ----KRVDRCSLQP------CRNGGLCLDLG-HAL----RCRCRAGFAGPRCEHDLDDCA 396
+ C+ P C N +D G H + CRC G+ GP C C
Sbjct: 656 GTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPACNQRA--CH 713
Query: 397 GRACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACA 456
R CA GTC +G +C C+ G+ G C P C GRC +G C C
Sbjct: 714 PR-CAEHGTCKDG----KCECSQGWNGEHCTIEGCPGL---CNSNGRCTLDQNGWHCVCQ 765
Query: 457 PGYMGARCE 465
PG+ GA C+
Sbjct: 766 PGWRGAGCD 774
Score = 63.5 bits (153), Expect = 5e-10
Identities = 44/171 (25%), Positives = 70/171 (40%), Gaps = 19/171 (11%)
Query: 219 VCRAGCSPEHGFCEQPGECRCLEGWTGPLCTVPVSTSSCLSPRGPSSATTGCLVPGPGP- 277
+C CS + ++ G C C WTGP C+ + + C S T C GP
Sbjct: 647 MCPDQCSGHGTYLQESGSCTCDPNWTGPDCSNEICSVDCGSHGVCMGGTCRCEEGWTGPA 706
Query: 278 CDGNP----CANGGSCSETPRSFECTCPRGFYGLRCEVSGVTCADGPCFNGGLCVGGADP 333
C+ CA G+C + +C C +G+ G C + G G C + G C
Sbjct: 707 CNQRACHPRCAEHGTCKDG----KCECSQGWNGEHCTIEG---CPGLCNSNGRC---TLD 756
Query: 334 DSAYICHCPPGFQGSNCEKRVDRCSLQPCRNGG----LCLDLGHALRCRCR 380
+ + C C PG++G+ C+ ++ N G C+D L+ C+
Sbjct: 757 QNGWHCVCQPGWRGAGCDVAMETLCTDSKDNEGDGLIDCMDPDCCLQSSCQ 807
Score = 38.9 bits (89), Expect = 0.013
Identities = 24/70 (34%), Positives = 29/70 (41%), Gaps = 11/70 (15%)
Query: 398 RACANGGTCVEGGGAHRCSCALGFGGRDCRERADPCAARPCAHGGRCYAHFSGLVCACAP 457
R C G CV G C C GF G DC A P C+ G+ +S C C
Sbjct: 520 RNCHGNGECVSG----TCHCFPGFLGPDCSRAACPVL---CSGNGQ----YSKGRCLCFS 568
Query: 458 GYMGARCEFP 467
G+ G C+ P
Sbjct: 569 GWKGTECDVP 578
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.141 0.485
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,055,016
Number of Sequences: 37866
Number of extensions: 2121460
Number of successful extensions: 13956
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 218
Number of HSP's successfully gapped in prelim test: 315
Number of HSP's that attempted gapping in prelim test: 7140
Number of HSP's gapped (non-prelim): 2699
length of query: 587
length of database: 18,247,518
effective HSP length: 108
effective length of query: 479
effective length of database: 14,157,990
effective search space: 6781677210
effective search space used: 6781677210
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.