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Search of human proteins with 45243524
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP),
member 9 isoform 1 [Homo sapiens]
(766 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 1503 0.0
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 1503 0.0
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 1399 0.0
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 479 e-135
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 464 e-130
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 447 e-125
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 403 e-112
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 367 e-101
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 318 2e-86
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 317 2e-86
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 314 2e-85
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 314 2e-85
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 314 2e-85
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 280 5e-75
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 234 3e-61
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 214 2e-55
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 168 2e-41
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 163 6e-40
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor... 162 1e-39
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor... 162 1e-39
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor... 162 1e-39
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 162 1e-39
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 154 4e-37
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ... 151 2e-36
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 147 3e-35
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 147 3e-35
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 146 6e-35
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 144 4e-34
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 143 7e-34
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 140 3e-33
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 1503 bits (3891), Expect = 0.0
Identities = 766/766 (100%), Positives = 766/766 (100%)
Query: 1 MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60
MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL
Sbjct: 1 MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60
Query: 61 LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120
LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF
Sbjct: 61 LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120
Query: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180
VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY
Sbjct: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180
Query: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240
TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS
Sbjct: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240
Query: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV
Sbjct: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
Query: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360
SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA
Sbjct: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360
Query: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420
LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL
Sbjct: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420
Query: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480
LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF
Sbjct: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480
Query: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540
EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP
Sbjct: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540
Query: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600
SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI
Sbjct: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600
Query: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN
Sbjct: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
Query: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ
Sbjct: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
Query: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766
QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
Sbjct: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 1503 bits (3891), Expect = 0.0
Identities = 766/766 (100%), Positives = 766/766 (100%)
Query: 1 MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60
MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL
Sbjct: 1 MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60
Query: 61 LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120
LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF
Sbjct: 61 LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120
Query: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180
VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY
Sbjct: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180
Query: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240
TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS
Sbjct: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240
Query: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV
Sbjct: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
Query: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360
SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA
Sbjct: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360
Query: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420
LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL
Sbjct: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420
Query: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480
LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF
Sbjct: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480
Query: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540
EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP
Sbjct: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540
Query: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600
SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI
Sbjct: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600
Query: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN
Sbjct: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
Query: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ
Sbjct: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
Query: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766
QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
Sbjct: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 1399 bits (3621), Expect = 0.0
Identities = 723/766 (94%), Positives = 723/766 (94%), Gaps = 43/766 (5%)
Query: 1 MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60
MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL
Sbjct: 1 MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60
Query: 61 LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120
LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF
Sbjct: 61 LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120
Query: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180
VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY
Sbjct: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180
Query: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240
TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS
Sbjct: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240
Query: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV
Sbjct: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
Query: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360
SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA
Sbjct: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360
Query: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420
LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSG
Sbjct: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSG--- 417
Query: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480
SVGSVYSGLMQGVGAAEKVF
Sbjct: 418 ----------------------------------------SVGSVYSGLMQGVGAAEKVF 437
Query: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540
EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP
Sbjct: 438 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 497
Query: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600
SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI
Sbjct: 498 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 557
Query: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN
Sbjct: 558 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 617
Query: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ
Sbjct: 618 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 677
Query: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766
QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
Sbjct: 678 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 723
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 479 bits (1234), Expect = e-135
Identities = 269/660 (40%), Positives = 405/660 (61%), Gaps = 31/660 (4%)
Query: 89 VCLFVGIYAMVKLLLFSEVRRP----IRDPWFWALFVWTYISLGASFLLWWLLSTVRPGT 144
+CL + ++ L+ R P PW W L + GA+ L W L + + P
Sbjct: 69 LCLATPLTVSLRALVAGASRAPPARVASAPWSWLL-----VGYGAAGLSWSLWAVLSP-- 121
Query: 145 QALEPGAATEAEGFPGSGRPPPEQASGATLQ-KLLSYTKPDVAFLVAASFFLIVAALGET 203
PG+ +Q + L +LL ++PD+ LVAA FFL++A LGET
Sbjct: 122 --------------PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGET 167
Query: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
+P+Y+GR ID + F++A+ +CL + GSS +AG RGG FT +R+N+R+R
Sbjct: 168 LIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIRE 227
Query: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
LF SL+ Q+ FF E +TG+L SRL+SDTT++S+ + N NV LR+ VKV G+ FM S
Sbjct: 228 QLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLS 287
Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
+S +L+L++ + P + +Y ++ + +E+Q+A+ARA E + ++TVRSF
Sbjct: 288 ISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGA 347
Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443
EE E Y L+Q +L + Y+ + L VQ+ +L G + G++T G
Sbjct: 348 EEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407
Query: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGR 503
+L++F+IY+ +G ++++ +Y ++ VGAAEKVF ++DRQP + G+LAP L+G
Sbjct: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGV 467
Query: 504 VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRV 563
V F++V+F Y RP VL+ ++F+L PG+VTALVGP+GSGKS+ +L+N Y GG+V
Sbjct: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527
Query: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
LLD KPIS Y+H YLH + V QEPVLF+ S+ +NI+YGL + + V+ AAQ A+A
Sbjct: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
Query: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 683
FI E++ G T+ GEKG+QL+ GQKQR+A+ARALVR+P VLILDEATSALD + E +Q
Sbjct: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQD 647
Query: 684 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
+ TVL+IAHRL V+ AH I+VL +G++ + QL LY++LVQ++++
Sbjct: 648 --WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEGQDLYSRLVQQRLM 702
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 464 bits (1193), Expect = e-130
Identities = 242/579 (41%), Positives = 377/579 (65%), Gaps = 3/579 (0%)
Query: 164 PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMD 223
P + SG +++LL + L +++++LGE +P++TGR D I+ S D
Sbjct: 223 PGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSAD 282
Query: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTG 283
F+ + ++ +L I S+ + GI+ ++ L+ +F +++ QET FF +N+TG
Sbjct: 283 TFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTG 342
Query: 284 DLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVS 343
+++SR+T DT+ +SD +S+N+++FL V+ ++ M S L++VT + P++ ++
Sbjct: 343 NIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLP 402
Query: 344 NIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNR 403
GK+Y+ L +V+ +LA++S A E +SAM TVRSFANEE EA+ + KLQ++ LN+
Sbjct: 403 KKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQ 462
Query: 404 KEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVG 463
KEA AY W + ++ ++++V ILY GG LV SG ++SGNL+ F++Y+ +E +
Sbjct: 463 KEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLL 522
Query: 464 SVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQ 523
S+Y + + VG++EK+FE++DR P G L P HLEG V F++V+F Y RP VLQ
Sbjct: 523 SIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQ 582
Query: 524 NVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVIS 583
++F+L PG+VTALVGP+GSGKS+ +L+N Y GG++LLDGKP+ Y+H+YLHR ++
Sbjct: 583 GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVA 642
Query: 584 LVSQEPVLFARSITDNISYGLPTVP-FEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQ 642
V QEP +F RS+ +NI+YGL P E + AA K+ AH FI L GY TE E G+Q
Sbjct: 643 AVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQ 702
Query: 643 LSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKH--TVLIIAHR 700
LSGGQ+Q VA+ARAL+R P VLILD+ATSALDA S+ ++Q ++ + +++ +VL+I
Sbjct: 703 LSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQH 762
Query: 701 LSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
LS VE A I+ L+ G + + GTHQQL+ + G Y +VQ
Sbjct: 763 LSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 447 bits (1151), Expect = e-125
Identities = 246/595 (41%), Positives = 367/595 (61%), Gaps = 26/595 (4%)
Query: 89 VCLFVGIYAMVKLLLFSEVRRP----IRDPWFWALFVWTYISLGASFLLWWLLSTVRPGT 144
+CL + ++ L+ R P PW W L + GA+ L W L + + P
Sbjct: 69 LCLATPLTVSLRALVAGASRAPPARVASAPWSWLL-----VGYGAAGLSWSLWAVLSP-- 121
Query: 145 QALEPGAATEAEGFPGSGRPPPEQASGATLQ-KLLSYTKPDVAFLVAASFFLIVAALGET 203
PG+ +Q + L +LL ++PD+ LVAA FFL++A LGET
Sbjct: 122 --------------PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGET 167
Query: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
+P+Y+GR ID + F++A+ +CL + GSS +AG RGG FT +R+N+R+R
Sbjct: 168 LIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIRE 227
Query: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
LF SL+ Q+ FF E +TG+L SRL+SDTT++S+ + N NV LR+ VKV G+ FM S
Sbjct: 228 QLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLS 287
Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
+S +L+L++ + P + +Y ++ + +E+Q+A+ARA E + ++TVRSF
Sbjct: 288 ISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGA 347
Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443
EE E Y L+Q +L + Y+ + L VQ+ +L G + G++T G
Sbjct: 348 EEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407
Query: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGR 503
+L++F+IY+ +G ++++ +Y ++ VGAAEKVF ++DRQP + G+LAP L+G
Sbjct: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGV 467
Query: 504 VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRV 563
V F++V+F Y RP VL+ ++F+L PG+VTALVGP+GSGKS+ +L+N Y GG+V
Sbjct: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527
Query: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
LLD KPIS Y+H YLH + V QEPVLF+ S+ +NI+YGL + + V+ AAQ A+A
Sbjct: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587
Query: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESE 678
FI E++ G T+ GEKG+QL+ GQKQR+A+ARALVR+P VLILDEATSALD + E
Sbjct: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 403 bits (1036), Expect = e-112
Identities = 235/595 (39%), Positives = 364/595 (61%), Gaps = 14/595 (2%)
Query: 159 PGS-GRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIV 217
PG GR P A +KLL P+ L AA FL ++++ P++ G+ ID I
Sbjct: 141 PGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIY 200
Query: 218 IQKSMDQFSTAVVIVCLLAIGSSFAAG-----IRGGIFTLIFARLNIRLRNCLFRSLVSQ 272
++D +S + +CL + + F G IR + R+ RLR LF S++ Q
Sbjct: 201 TNPTVD-YSDNLTRLCL-GLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQ 258
Query: 273 ETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVT 332
E +FFD+ RTG+LI+RL+SDT ++ V++N++ LR + + + MF +S L+
Sbjct: 259 EVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFV 318
Query: 333 FMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYL 392
P + +++ IYG+Y ++L+K Q++LA+A+ AEE I ++TVR+F E E E Y
Sbjct: 319 LSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYA 378
Query: 393 RKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYE 452
K+ V +L RKEA A + +GL+ ++ +S+LY GG L+ S MT G L +F++Y
Sbjct: 379 SKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYA 438
Query: 453 FVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLEGRVDFENVT 510
F +G + + S YS LM+G+GA +++E ++R+P + + L +G ++F+NV
Sbjct: 439 FWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVH 498
Query: 511 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
F Y RP + Q+ S S+ G VTALVGPSGSGKS+ +++L Y G + LDG I
Sbjct: 499 FAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDI 558
Query: 571 SAYDHKYLHRVISLVSQEPVLFARSITDNISYGL---PTVPFEMVVEAAQKANAHGFIME 627
+ +L I VSQEP+LF+ SI +NI+YG +V E + A+ ANA FI
Sbjct: 559 RQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRN 618
Query: 628 LQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHG 687
G++T GEKG LSGGQKQR+A+ARAL++NP +L+LDEATSALDAE+EYL+Q+A+
Sbjct: 619 FPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDR 678
Query: 688 NLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQ 741
+ TVL+IAHRLST+++A+++ VLD+G++ + G H++LL++ G+Y KL+ +Q
Sbjct: 679 LMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 733
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 367 bits (941), Expect = e-101
Identities = 220/603 (36%), Positives = 342/603 (56%), Gaps = 11/603 (1%)
Query: 151 AATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG 210
A EAE P + P S + + P + L A + AAL +P G
Sbjct: 94 ALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLG 153
Query: 211 RAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRG----GIFTLIF---ARLNIRLRN 263
+ ++ +V + + D + + L+ G++G G L+ R+ + +R
Sbjct: 154 QLVE-VVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRR 212
Query: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
LF SL+ Q+ +FFD N+TG L+SRLT+D I+ LR+ +V G +V +
Sbjct: 213 ALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSM 272
Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
LS +L+L+ + P +M V + G ++LS++ Q +ARA A+E + ++TVR+FA
Sbjct: 273 LSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAM 332
Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443
E+ E E Y +L+ + + S + + + L+ GG LV Q+T G
Sbjct: 333 EQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGG 392
Query: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLE 501
+L++F++ + M ++ ++ +++G+ A +VFE++ P + G + + L
Sbjct: 393 DLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR 452
Query: 502 GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGG 561
G V F+NV F+Y RP +VL++ + +L PGK+ ALVG SG GK++ ++LE FY G
Sbjct: 453 GSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAG 512
Query: 562 RVLLDGKPISAYDHKYLH-RVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 620
V+LDG+ + D +L +V+ +SQEPVLF +I +NI +G E V AA++AN
Sbjct: 513 VVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREAN 572
Query: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
AH FI +GY+T GE+G LSGGQKQR+A+ARAL++ P VLILDEATSALDAESE +
Sbjct: 573 AHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERV 632
Query: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
+Q+A+ TVL+IAHRLSTV AH IVV+ GRV + GTH++LL +GGLYA+L++R
Sbjct: 633 VQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRR 692
Query: 741 QML 743
Q L
Sbjct: 693 QAL 695
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 318 bits (814), Expect = 2e-86
Identities = 193/587 (32%), Positives = 316/587 (53%), Gaps = 15/587 (2%)
Query: 164 PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG--RAIDGIVIQKS 221
P E+ A ++++L ++ P+ +++ S + AA+ T P Y I G
Sbjct: 731 PVQEEVEPAPVRRILKFSAPEWPYMLVGS---VGAAVNGTVTPLYAFLFSQILGTFSIPD 787
Query: 222 MDQFSTAVVIVCLLAIG----SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFF 277
++ + + VCLL + S F ++G F L RLR FR+++ Q+ ++F
Sbjct: 788 KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWF 847
Query: 278 DE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMG 335
D+ N G L +RL +D + V I + + + VT ++ FS SW+LSLV
Sbjct: 848 DDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCF 907
Query: 336 FPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKL 395
FP + + + + + AL E +S ++TV E E +L
Sbjct: 908 FPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETEL 967
Query: 396 QQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
++ +K ++A Y + + + + + YGG+L+ + + + I +
Sbjct: 968 EKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLS 1027
Query: 456 GDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP--TMVHDGSLAPDHLEGRVDFENVTFTY 513
+ S + +A + F+ +DRQP ++ + D+ +G++DF + FTY
Sbjct: 1028 ATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTY 1087
Query: 514 RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAY 573
+RP +QVL +S S+SPG+ A VG SG GKS+ + +LE FY + G+V++DG
Sbjct: 1088 PSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKV 1147
Query: 574 DHKYLHRVISLVSQEPVLFARSITDNISYGLPT--VPFEMVVEAAQKANAHGFIMELQDG 631
+ ++L I +VSQEPVLFA SI DNI YG T +P E V+ AA++A H F+M L +
Sbjct: 1148 NVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1207
Query: 632 YSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQK 691
Y T G +G+QLS G+KQR+A+ARA+VR+P +L+LDEATSALD ESE +Q A+ +
Sbjct: 1208 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREG 1267
Query: 692 HTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLV 738
T ++IAHRLST+++A +I V+ +G V+++GTH++L+AQ G Y KLV
Sbjct: 1268 RTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314
Score = 308 bits (788), Expect = 2e-83
Identities = 180/546 (32%), Positives = 291/546 (53%), Gaps = 27/546 (4%)
Query: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
F YY G A+ ++ T + +C I + AR ++R
Sbjct: 141 FASYYAGIAVAVLI---------TGYIQICFWVIAA---------------ARQIQKMRK 176
Query: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
FR ++ E +FD N G+L +R + D ++D ++ + +F++ + F
Sbjct: 177 FYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFF 236
Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
W+L+LV P+I + + G + + A A+A A+E IS+M+TV +F
Sbjct: 237 RGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGG 296
Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVIS-GQMTS 442
E+ E E Y + L + ++ ++ + + +YG LV+ G+ T
Sbjct: 297 EKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTP 356
Query: 443 GNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHL 500
G L+ + V + + G AA +FE IDR+P + + + D +
Sbjct: 357 GTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI 416
Query: 501 EGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEG 560
+G ++F NVTF Y +RP ++L +++ + PG++TALVGPSG+GKS+ + +++ FY
Sbjct: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476
Query: 561 GRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 620
G V +DG I + + ++L I +V QEPVLF+ +I +NI YG E +V+AA++AN
Sbjct: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536
Query: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
A+ FIM+L + T GE G Q+SGGQKQRVA+ARAL+RNP +L+LD ATSALD ESE +
Sbjct: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596
Query: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
+Q+ + HT++ +AHRLSTV A I+ + G V++GTH++LL + G+Y LV
Sbjct: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTL 656
Query: 741 QMLGLQ 746
Q G Q
Sbjct: 657 QSQGNQ 662
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 317 bits (813), Expect = 2e-86
Identities = 180/526 (34%), Positives = 302/526 (57%), Gaps = 14/526 (2%)
Query: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
+ G AA I+ + L R ++R F +++ QE +FD + G+L +RLT D +
Sbjct: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
Query: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
+++ + I +F ++ + F+ W+L+LV P++ + + ++ K +
Sbjct: 181 KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT 240
Query: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
+ A A+A AEE ++A++TV +F +++E E Y + L++ ++ K+A +
Sbjct: 241 DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG 300
Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLI----AFIIYEFVLGDCMESVGSVYSGLM 470
+ L + +YG LV+SG+ + G ++ + +I F +G S+
Sbjct: 301 AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSI----EAFA 356
Query: 471 QGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFS 528
GAA ++F+ ID +P++ PD+++G ++F NV F+Y +R ++L+ ++
Sbjct: 357 NARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLK 416
Query: 529 LSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQE 588
+ G+ ALVG SG GKS+ V +++ Y G V +DG+ I + ++L +I +VSQE
Sbjct: 417 VQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQE 476
Query: 589 PVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQK 648
PVLFA +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQK
Sbjct: 477 PVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQK 536
Query: 649 QRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAH 708
QR+A+ARALVRNP +L+LDEATSALD ESE ++Q A+ + T ++IAHRLSTV +A
Sbjct: 537 QRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNAD 596
Query: 709 LIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLG----LQPAAD 750
+I D G +V++G H +L+ + G+Y KLV Q G L+ AAD
Sbjct: 597 VIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAAD 642
Score = 306 bits (783), Expect = 6e-83
Identities = 192/499 (38%), Positives = 278/499 (55%), Gaps = 22/499 (4%)
Query: 257 LNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKV 314
L RLR +FRS++ Q+ S+FD+ N TG L +RL +D V + + V +N +
Sbjct: 784 LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANL 843
Query: 315 TGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISA 374
++ F WQL+L+ PII + + K + + + L + A E I
Sbjct: 844 GTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIEN 903
Query: 375 MKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-YGGH 433
+TV S E++ +Y + LQ Y+ + ++A + G+T Q + + Y G
Sbjct: 904 FRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-------GITFSFTQAMMYFSYAGC 956
Query: 434 LVISGQMTSGNLIAF----IIYEFVLGDCMESVGSVYSGLMQGVGA---AEKVFEFIDRQ 486
+ + L++F +++ V+ M +VG V S A A + I++
Sbjct: 957 FRFGAYLVAHKLMSFEDVLLVFSAVVFGAM-AVGQVSSFAPDYAKAKISAAHIIMIIEKT 1015
Query: 487 PTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSG 544
P + L P+ LEG V F V F Y TRP VLQ +S + G+ ALVG SG G
Sbjct: 1016 PLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCG 1075
Query: 545 KSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG- 603
KS+ V +LE FY G+VLLDGK I + ++L + +VSQEP+LF SI +NI+YG
Sbjct: 1076 KSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGD 1135
Query: 604 -LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPP 662
V E +V AA++AN H FI L + YST+ G+KG QLSGGQKQR+A+ARALVR P
Sbjct: 1136 NSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPH 1195
Query: 663 VLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQG 722
+L+LDEATSALD ESE ++Q+A+ + T ++IAHRLST+++A LIVV GRV + G
Sbjct: 1196 ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHG 1255
Query: 723 THQQLLAQGGLYAKLVQRQ 741
THQQLLAQ G+Y +V Q
Sbjct: 1256 THQQLLAQKGIYFSMVSVQ 1274
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 314 bits (805), Expect = 2e-85
Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)
Query: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
L G AA I+ +TL R ++R F +++ QE +FD N T +L +RLT D +
Sbjct: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
Query: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
+S+ + + +F + + F W+L+LV PI+ + + ++ K S
Sbjct: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
Query: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
+ A A+A AEE + A++TV +F + +E E Y + L+ ++ K+A + +
Sbjct: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
+ L + +YG LVIS + T GN + + + G
Sbjct: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
Query: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
AA +F+ ID P + + PD ++G ++F +V F+Y +R + ++L+ ++ + G
Sbjct: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
Query: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
+ ALVG SG GKS+ V +++ Y + G + +DG+ I ++ YL +I +VSQEPVLF
Sbjct: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
Query: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
+ +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
Query: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
+ARALVRNP +L+LDEATSALD ESE +Q A+ + T ++IAHRLSTV +A +I
Sbjct: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
Query: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
+ G +V+QG+H +L+ + G+Y KLV Q G Q
Sbjct: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
Score = 299 bits (765), Expect = 7e-81
Identities = 198/549 (36%), Positives = 291/549 (53%), Gaps = 32/549 (5%)
Query: 214 DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
D V Q+ + FS +I L I S F ++G F L RLR+ F++++ Q+
Sbjct: 743 DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
Query: 274 TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
S+FD+ N TG L +RL +D V + + +N + ++ F WQL+L+
Sbjct: 800 MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
Query: 332 TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
PII + + K +K + L A A E I ++TV S E + +Y
Sbjct: 860 LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
Query: 392 LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-------YGGHLVISGQMTSGN 444
+ KL Y+ + ++A Y G+T + Q + + +G +L+++G M +
Sbjct: 920 VEKLYGPYRNSVQKAHIY-------GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD 972
Query: 445 LIAFIIYEFVLGD-CMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLE 501
+I + V G + S + +A +F +RQP + + L PD E
Sbjct: 973 VI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE 1031
Query: 502 GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFY-PLEG 560
G + F V F Y TR + VLQ +S + G+ ALVG SG GKS+ V +LE FY PL G
Sbjct: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091
Query: 561 ------GRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMV 612
G LLDG+ + ++L + +VSQEP+LF SI +NI+YG V + +
Sbjct: 1092 TVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI 1151
Query: 613 VEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSA 672
V AA+ AN H FI L Y T G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSA
Sbjct: 1152 VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSA 1211
Query: 673 LDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGG 732
LD ESE ++Q+A+ + T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ G
Sbjct: 1212 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1271
Query: 733 LYAKLVQRQ 741
+Y +V Q
Sbjct: 1272 IYFSMVSVQ 1280
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 314 bits (805), Expect = 2e-85
Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)
Query: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
L G AA I+ +TL R ++R F +++ QE +FD N T +L +RLT D +
Sbjct: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
Query: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
+S+ + + +F + + F W+L+LV PI+ + + ++ K S
Sbjct: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
Query: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
+ A A+A AEE + A++TV +F + +E E Y + L+ ++ K+A + +
Sbjct: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
+ L + +YG LVIS + T GN + + + G
Sbjct: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
Query: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
AA +F+ ID P + + PD ++G ++F +V F+Y +R + ++L+ ++ + G
Sbjct: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
Query: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
+ ALVG SG GKS+ V +++ Y + G + +DG+ I ++ YL +I +VSQEPVLF
Sbjct: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
Query: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
+ +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
Query: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
+ARALVRNP +L+LDEATSALD ESE +Q A+ + T ++IAHRLSTV +A +I
Sbjct: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
Query: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
+ G +V+QG+H +L+ + G+Y KLV Q G Q
Sbjct: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
Score = 282 bits (721), Expect = 9e-76
Identities = 189/534 (35%), Positives = 267/534 (50%), Gaps = 56/534 (10%)
Query: 214 DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
D V Q+ + FS +I L I S F ++G F L RLR+ F++++ Q+
Sbjct: 743 DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
Query: 274 TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
S+FD+ N TG L +RL +D V + + +N + ++ F WQL+L+
Sbjct: 800 MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
Query: 332 TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
PII + + K +K + L A A E I ++TV S E + +Y
Sbjct: 860 LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
Query: 392 LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIY 451
+ KL YG + V S A +
Sbjct: 920 VEKL----------------------------------YGPYRVFS---------AIVFG 936
Query: 452 EFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENV 509
LG + +A +F +RQP + + L PD EG + F V
Sbjct: 937 AVALGHASSFAPDYAKAKL----SAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEV 992
Query: 510 TFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKP 569
F Y TR + VLQ +S + G+ ALVG SG GKS+ V +LE FY G VLLDG+
Sbjct: 993 VFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQE 1052
Query: 570 ISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 627
+ ++L + +VSQEP+LF SI +NI+YG V + +V AA+ AN H FI
Sbjct: 1053 AKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET 1112
Query: 628 LQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHG 687
L Y T G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE ++Q+A+
Sbjct: 1113 LPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK 1172
Query: 688 NLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
+ T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ G+Y +V Q
Sbjct: 1173 AREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 314 bits (805), Expect = 2e-85
Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)
Query: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
L G AA I+ +TL R ++R F +++ QE +FD N T +L +RLT D +
Sbjct: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182
Query: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
+S+ + + +F + + F W+L+LV PI+ + + ++ K S
Sbjct: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242
Query: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
+ A A+A AEE + A++TV +F + +E E Y + L+ ++ K+A + +
Sbjct: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302
Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
+ L + +YG LVIS + T GN + + + G
Sbjct: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362
Query: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
AA +F+ ID P + + PD ++G ++F +V F+Y +R + ++L+ ++ + G
Sbjct: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422
Query: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
+ ALVG SG GKS+ V +++ Y + G + +DG+ I ++ YL +I +VSQEPVLF
Sbjct: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482
Query: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
+ +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542
Query: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
+ARALVRNP +L+LDEATSALD ESE +Q A+ + T ++IAHRLSTV +A +I
Sbjct: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602
Query: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
+ G +V+QG+H +L+ + G+Y KLV Q G Q
Sbjct: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636
Score = 304 bits (779), Expect = 2e-82
Identities = 196/542 (36%), Positives = 289/542 (53%), Gaps = 25/542 (4%)
Query: 214 DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
D V Q+ + FS +I L I S F ++G F L RLR+ F++++ Q+
Sbjct: 743 DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799
Query: 274 TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
S+FD+ N TG L +RL +D V + + +N + ++ F WQL+L+
Sbjct: 800 MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859
Query: 332 TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
PII + + K +K + L A A E I ++TV S E + +Y
Sbjct: 860 LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919
Query: 392 LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-------YGGHLVISGQMTSGN 444
+ KL Y+ + ++A Y G+T + Q + + +G +L+++G M +
Sbjct: 920 VEKLYGPYRNSVQKAHIY-------GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD 972
Query: 445 LIAFIIYEFVLGD-CMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLE 501
+I + V G + S + +A +F +RQP + + L PD E
Sbjct: 973 VI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE 1031
Query: 502 GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGG 561
G + F V F Y TR + VLQ +S + G+ ALVG SG GKS+ V +LE FY G
Sbjct: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091
Query: 562 RVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKA 619
VLLDG+ + ++L + +VSQEP+LF SI +NI+YG V + +V AA+ A
Sbjct: 1092 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1151
Query: 620 NAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEY 679
N H FI L Y T G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE
Sbjct: 1152 NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1211
Query: 680 LIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
++Q+A+ + T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ G+Y +V
Sbjct: 1212 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1271
Query: 740 RQ 741
Q
Sbjct: 1272 VQ 1273
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 280 bits (715), Expect = 5e-75
Identities = 191/601 (31%), Positives = 309/601 (51%), Gaps = 55/601 (9%)
Query: 173 TLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYT---GRAI------DGIVIQKSMD 223
+L K+L KP+ F+V + + + L T P ++ + I D ++ +
Sbjct: 232 SLLKILKLNKPEWPFVVLGT---LASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAE 288
Query: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NR 281
+S VI+ ++ S F G+ G I L +RLR+ F++++ Q+ ++FDE N
Sbjct: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEI---LTMRLRHLAFKAMLYQDIAWFDEKENS 345
Query: 282 TGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMM 341
TG L + L D + I V +N + V+ F W+++ + P++ +
Sbjct: 346 TGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAV 405
Query: 342 VSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKL 401
I + + + L A A E + ++T+ S E+ ++Y LQ ++
Sbjct: 406 TGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRN 465
Query: 402 NRKEAA----------AYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIY 451
K+A A++Y+ + +G +G +L+ +G+MT + FI++
Sbjct: 466 TSKKAQIIGSCYAFSHAFIYFAYAAGFR----------FGAYLIQAGRMTPEGM--FIVF 513
Query: 452 EFVLGDCMESVGSV------YSGLMQGVGAAEKVFEFIDRQPTM---VHDGSLAPDHLEG 502
+ M ++G YS G A +F ++++P + +G PD EG
Sbjct: 514 TAIAYGAM-AIGETLVLAPEYSKAKSG---AAHLFALLEKKPNIDSRSQEGK-KPDTCEG 568
Query: 503 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 562
++F V+F Y RP +L+ +S S+ GK A VG SG GKS+ V +L+ Y G+
Sbjct: 569 NLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQ 628
Query: 563 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKAN 620
VL DG + ++L I++V QEPVLF SI +NI+YG VP + + EAA AN
Sbjct: 629 VLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAAN 688
Query: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
H FI L + Y+T+ G KGAQLSGGQKQR+A+ARAL++ P +L+LDEATSALD +SE +
Sbjct: 689 IHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKV 748
Query: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
+Q A+ T L++ HRLS +++A LIVVL G++ +QGTHQ+LL +Y KLV
Sbjct: 749 VQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 808
Query: 741 Q 741
Q
Sbjct: 809 Q 809
Score = 171 bits (432), Expect = 3e-42
Identities = 89/178 (50%), Positives = 124/178 (69%)
Query: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
++D I A + ++ I +VSQEPVLF +I++NI YG V E + AA++ANA+
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60
Query: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 683
FIME + ++T GEKGAQ+SGGQKQR+A+ARALVRNP +LILDEATSALD+ES+ +Q
Sbjct: 61 FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120
Query: 684 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
A+ + T +++AHRLST+ A LIV L G + ++G H +L+A+ GLY LV Q
Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 234 bits (596), Expect = 3e-61
Identities = 186/659 (28%), Positives = 317/659 (48%), Gaps = 38/659 (5%)
Query: 115 WFWA-----------LFVWTYISLGASFLLWWLLSTVRPGTQAL---EPGAATEAEGFPG 160
W+WA L+V Y+ G F+L +RP + L E E
Sbjct: 173 WWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRS 232
Query: 161 SGRPPPEQASGATLQKLLSYTKP------DVAFLVAASFFLIVAALGETFLPYYTGRAID 214
+ + + G L+ L Y P + L+ + AL +Y R I
Sbjct: 233 AAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFY--RNIV 290
Query: 215 GIVIQK----SMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARL----NIRLRNCLF 266
++ +K S+ T+ V + L G + + G + T ++ R+ + R+ +F
Sbjct: 291 NLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIF 350
Query: 267 RSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNI-NVFLRNTVKVTGVVVF-MFSL 324
L + RTG+++ T+ V+ L+S + NV + G++ F MF
Sbjct: 351 SHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFN 410
Query: 325 SWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANE 384
+W L+ F+ + + ++ + ++ + + + A +++ +TV+ + E
Sbjct: 411 AW-FGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAE 469
Query: 385 EEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGN 444
E E Y + + L K +A+ + L + + ++ + V ++ G+
Sbjct: 470 SYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGD 529
Query: 445 LIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHD--GSLAPDHLEG 502
+ F Y L + G+ Y + E +F+ + ++ T V D G+ +G
Sbjct: 530 YVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLL-KEETEVKDLPGAGPLRFQKG 588
Query: 503 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 562
R++FENV F+Y T LQ+VSF++ PG+ ALVGPSG+GKS+ + +L FY + G
Sbjct: 589 RIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGC 646
Query: 563 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAH 622
+ +DG+ IS L I +V Q+ VLF +I DNI YG T + V AAQ A H
Sbjct: 647 IRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIH 706
Query: 623 GFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQ 682
IM +GY T+ GE+G +LSGG+KQRVA+AR +++ P +++LDEATSALD +E IQ
Sbjct: 707 DAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQ 766
Query: 683 QAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
++ T +++AHRLSTV +A I+V+ G +V++G H+ LL++GG+YA + Q Q
Sbjct: 767 ASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 214 bits (545), Expect = 2e-55
Identities = 177/602 (29%), Positives = 292/602 (48%), Gaps = 38/602 (6%)
Query: 174 LQKLLSYT----KPDVAFLVAASF-FLIVAALGETFLPYYTGRAIDGI-VIQKSMDQFST 227
++ +LSY +PD+ VA S FL A +P+ A+D + + +M S
Sbjct: 122 IKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSD 181
Query: 228 AVVIVCLLAI-----------GSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSF 276
A V +A G++F +R +F + R+ +F L + + F
Sbjct: 182 APNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGF 241
Query: 277 FDENRTGDLISRLTSDTTMVSDLVSQ---NINVFLRNTVKVTGVVVF----MFSLSWQLS 329
+TG L + T +S ++S N+ + + V+GV+ + F+L +
Sbjct: 242 HLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGT 301
Query: 330 LVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAE 389
L T+ F + + ++ R E+ A A N A +++ +TV+ F NE EA+
Sbjct: 302 LGTYTAFTVAVT------RWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQ 355
Query: 390 VYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFI 449
Y L+ + K + +G V +I+ +++G +T G+L+
Sbjct: 356 RYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVN 415
Query: 450 IYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPD----HLEGRVD 505
F L + +G+VY Q + +F + + T + D +A V
Sbjct: 416 GLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLL-KVDTQIKDKVMASPLQITPQTATVA 474
Query: 506 FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLL 565
F+NV F Y +VL +SF + GK A+VG SGSGKS+ V +L FY + G + L
Sbjct: 475 FDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYL 532
Query: 566 DGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFI 625
G+ I + L R + +V Q+ VLF +I N+ YG + E V A+ A H I
Sbjct: 533 AGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAI 592
Query: 626 MELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAI 685
+ + GY T+ GE+G +LSGG+KQRVA+ARA++++PPV++ DEATS+LD+ +E I A+
Sbjct: 593 LRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAM 652
Query: 686 HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQMLG 744
++ T + IAHRLSTV A I+VLD+G+V ++GTH LLA +Y+++ Q
Sbjct: 653 KDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSR 712
Query: 745 LQ 746
+Q
Sbjct: 713 VQ 714
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 168 bits (426), Expect = 2e-41
Identities = 127/512 (24%), Positives = 247/512 (48%), Gaps = 29/512 (5%)
Query: 235 LAIGSSFAAGIRGGIFTLI--------FARLNIRLRNCLFRSLVSQETSFFDENRTGDLI 286
+ +G A G+ GIF I F + L L +++ FFD TG ++
Sbjct: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081
Query: 287 SRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIY 346
+R D + V D + Q++ ++ + + +V + + +++ I + V Y
Sbjct: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFY 1141
Query: 347 GKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
++L + + + ET+S + +R+F +++ +L+ + N+K
Sbjct: 1142 VSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQR----FLKHNEVRIDTNQKCV 1197
Query: 407 AAYMYYVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDCMESVGS 464
+++ + L LV +++ + +VI SG+ + F++ + + + +
Sbjct: 1198 FSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVR 1257
Query: 465 VYSGLMQGVGAAEKVFEF--IDRQPTMVHDGSLAPDH-LEGRVDFENVTFTYRTRPHTQV 521
+ S + + A E++ E+ ++ + V D PD +G++ F N YR V
Sbjct: 1258 MTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL-V 1316
Query: 522 LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 581
L+ ++ + + +VG +G+GKSS N L GG++++DG I++ L
Sbjct: 1317 LRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREK 1376
Query: 582 ISLVSQEPVLFARSITDNISYGLPTVPF-----EMVVEAAQKANAHGFIMELQDGYSTET 636
++++ Q+P+LF+ S+ N+ PF E + +A + A+ F+ LQ G S E
Sbjct: 1377 LTIIPQDPILFSGSLRMNLD------PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEV 1430
Query: 637 GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLI 696
E G LS GQ+Q + + RAL+R +L+LDEAT+A+D E++ LIQ I TV+
Sbjct: 1431 TEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVIT 1490
Query: 697 IAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL 728
IAHRL T+ + ++VLD G++++ G+ ++LL
Sbjct: 1491 IAHRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522
Score = 103 bits (258), Expect = 5e-22
Identities = 114/511 (22%), Positives = 229/511 (44%), Gaps = 59/511 (11%)
Query: 250 FTLIFARLNIRLRNCLFRSLVSQETSFFD----ENRTGDLISRLTSDTTMVSDLVSQNIN 305
F L F +L +++R + S+ + + + E G+ ++ ++ D + D+ N
Sbjct: 382 FQLCF-KLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVT----N 436
Query: 306 VFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMV---SNIYGKYYKRLSKEVQNALA 362
V +V+ +F L +L G ++++V + I K + +
Sbjct: 437 FMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKD 496
Query: 363 RASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLV 422
+ E +S +K ++ FA E + QV L +KE + + + + V
Sbjct: 497 KRLKIMNEILSGIKILKYFAWEPSFRD-------QVQNLRKKELKNLLAFSQLQCVVIFV 549
Query: 423 VQ-----VSILYYGGHL------VISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQ 471
Q VS++ + ++ ++ Q ++ F I F L + + S ++Q
Sbjct: 550 FQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS----MLPMMISSMLQ 605
Query: 472 GVGAAEKVFEFIDRQPTMVHDGSLAPD-HLEGRVDFENVTFTYRTRPHTQVLQNVSFSLS 530
+ E++ +++ + ++ D + + + F +FT+ V ++V+ +
Sbjct: 606 ASVSTERLEKYLGGDD--LDTSAIRHDCNFDKAMQFSEASFTWEHDSEATV-RDVNLDIM 662
Query: 531 PGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPV 590
G++ A++GP GSGKSS ++ + G+ + + H + + V Q+
Sbjct: 663 AGQLVAVIGPVGSGKSSLISAML-------------GEMENVHGHITIKGTTAYVPQQSW 709
Query: 591 LFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQK 648
+ +I DNI +G ++ V+EA + L G E GEKG LSGGQK
Sbjct: 710 IQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGEKGINLSGGQK 766
Query: 649 QRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVE 705
QR+++ARA +N + +LD+ SA+DA +++ + + +G L+ T L++ H + +
Sbjct: 767 QRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLP 826
Query: 706 HAHLIVVLDKGRVVQQGTHQQLLAQGGLYAK 736
IVVL G +V++G++ LLA+ G +AK
Sbjct: 827 QVDEIVVLGNGTIVEKGSYSALLAKKGEFAK 857
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 163 bits (412), Expect = 6e-40
Identities = 140/502 (27%), Positives = 238/502 (47%), Gaps = 33/502 (6%)
Query: 245 IRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNI 304
IRG +F R + RL + LFR ++ FFD TG +++R + D V +
Sbjct: 931 IRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQA 990
Query: 305 NVFLRNTVKV---TGVVVFMFSLSWQLSLV--TFMGFPIIMMVSNIYGKYYKRLSKEVQN 359
+F++N + V G++ +F W L V + F ++ +VS + + KRL Q+
Sbjct: 991 EMFIQNVILVFFCVGMIAGVFP--WFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQS 1048
Query: 360 ALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT 419
+ +I + T+ ++ +E +L + Q++ N+ + + +
Sbjct: 1049 PFL---SHITSSIQGLATIHAYNKGQE----FLHRYQELLDDNQAPFFLFTCAMRWLAVR 1101
Query: 420 LLVVQVSILYYGGHLVI--SGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAE 477
L ++ ++++ G +++ GQ+ I Y L + + S + E
Sbjct: 1102 LDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVE 1161
Query: 478 KVFEFID----RQPTMVHDGSLAPDH-LEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
++ +I P + + + +PD EG V FEN YR VL+ VSF++ P
Sbjct: 1162 RINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL-VLKKVSFTIKPK 1220
Query: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
+ +VG +GSGKSS L L GG + +DG IS L +S++ QEPVLF
Sbjct: 1221 EKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLF 1280
Query: 593 ARSITDNISYGLPTVPFEMVVE-----AAQKANAHGFIMELQDGYSTETGEKGAQLSGGQ 647
+ ++ N+ PF E A ++ + I +L +E E G S G+
Sbjct: 1281 SGTVRSNLD------PFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGE 1334
Query: 648 KQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHA 707
+Q + +ARAL+R+ +LILDEAT+A+D E++ LIQ+ I T+L IAHRL TV +
Sbjct: 1335 RQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGS 1394
Query: 708 HLIVVLDKGRVVQQGTHQQLLA 729
I+VL +G+VV+ T LL+
Sbjct: 1395 DRIMVLAQGQVVEFDTPSVLLS 1416
Score = 103 bits (257), Expect = 6e-22
Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 18/247 (7%)
Query: 520 QVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLH 579
+ L ++ + GK+ + G GSGK+S ++ + L G + + G
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 623
Query: 580 RVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEK 639
+ V+Q+ + ++ DNI +G E + L TE GE+
Sbjct: 624 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681
Query: 640 GAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIA 698
GA LSGGQ+QR+++ARAL + + ILD+ SALDA ++ AI +L+ TVL +
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741
Query: 699 HRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEP 758
H+L + ++ + +G + ++GTH++L+ G YA + +LG P + +++
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEI---NSKK 798
Query: 759 VANGSHK 765
+GS K
Sbjct: 799 ETSGSQK 805
>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
[Homo sapiens]
Length = 1475
Score = 162 bits (409), Expect = 1e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 996 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1055
Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 1056 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1112
Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 1113 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1168
Query: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 1169 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1228
Query: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 1229 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1287
Query: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 1288 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1341
Query: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 1342 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1401
Query: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 1402 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1461
Query: 731 GGLYAKLVQ 739
GL+ + +
Sbjct: 1462 RGLFYSMAK 1470
Score = 53.5 bits (127), Expect = 7e-07
Identities = 93/502 (18%), Positives = 198/502 (39%), Gaps = 102/502 (20%)
Query: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
Query: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
Query: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
Query: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
Query: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTAL 537
L PD +E R + N TFT+ R L ++FS+ G + A+
Sbjct: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAV 676
Query: 538 VGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSIT 597
VG G GKSS ++ L G V + G ++ V Q+ + S+
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLR 723
Query: 598 DNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARAL 657
+NI + G QL + V A AL
Sbjct: 724 ENILF-------------------------------------GCQLEEPYYRSVIQACAL 746
Query: 658 VRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGR 717
+ + +L + T + + T +++ H +S + +I+V+ G+
Sbjct: 747 LPDLEILPSGDRT-----------------EIGEKTRILVTHSMSYLPQVDVIIVMSGGK 789
Query: 718 VVQQGTHQQLLAQGGLYAKLVQ 739
+ + G++Q+LLA+ G +A+ ++
Sbjct: 790 ISEMGSYQELLARDGAFAEFLR 811
>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
[Homo sapiens]
Length = 1416
Score = 162 bits (409), Expect = 1e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 937 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 996
Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 997 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1053
Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 1054 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1109
Query: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 1110 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1169
Query: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 1170 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1228
Query: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 1229 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1282
Query: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 1283 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1342
Query: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 1343 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402
Query: 731 GGLYAKLVQ 739
GL+ + +
Sbjct: 1403 RGLFYSMAK 1411
Score = 43.9 bits (102), Expect = 6e-04
Identities = 68/344 (19%), Positives = 144/344 (41%), Gaps = 35/344 (10%)
Query: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
Query: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
Query: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
Query: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
Query: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTAL 537
L PD +E R + N TFT+ R L ++FS+ G + A+
Sbjct: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAV 676
Query: 538 VGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 581
VG G GKSS ++ L G V + + + + YL +V
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720
Score = 40.0 bits (92), Expect = 0.008
Identities = 19/69 (27%), Positives = 42/69 (60%), Gaps = 5/69 (7%)
Query: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
SAL AE + + G++ T +++ H +S + +I+V+ G++ + G++Q+LLA+
Sbjct: 689 SALLAEMD-----KVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743
Query: 731 GGLYAKLVQ 739
G +A+ ++
Sbjct: 744 DGAFAEFLR 752
>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
[Homo sapiens]
Length = 1472
Score = 162 bits (409), Expect = 1e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 993 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1052
Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 1053 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1109
Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 1110 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1165
Query: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 1166 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1225
Query: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 1226 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1284
Query: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 1285 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1338
Query: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 1339 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1398
Query: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 1399 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458
Query: 731 GGLYAKLVQ 739
GL+ + +
Sbjct: 1459 RGLFYSMAK 1467
Score = 74.3 bits (181), Expect = 4e-13
Identities = 36/104 (34%), Positives = 67/104 (64%), Gaps = 3/104 (2%)
Query: 639 KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVL 695
KG LSGGQKQRV++ARA+ N + + D+ SA+DA +++ + I G L+ T +
Sbjct: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764
Query: 696 IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
++ H +S + +I+V+ G++ + G++Q+LLA+ G +A+ ++
Sbjct: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 808
Score = 42.7 bits (99), Expect = 0.001
Identities = 67/334 (20%), Positives = 140/334 (41%), Gaps = 35/334 (10%)
Query: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
Query: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
Query: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
Query: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
Query: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTAL 537
L PD +E R + N TFT+ R L ++FS+ G + A+
Sbjct: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAV 676
Query: 538 VGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS 571
VG G GKSS ++ L G V + G +S
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 162 bits (409), Expect = 1e-39
Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)
Query: 265 LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
L S++ SFF+ +G+L++R + + V ++ + I +F+ + V G +V + +
Sbjct: 1052 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1111
Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
++ +G I V Y ++L + + + + ET+ + +R+F
Sbjct: 1112 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1168
Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
EE+E ++ Q K++ + A Y V L + + V +L+ VIS
Sbjct: 1169 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1224
Query: 441 TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
S L+ + Y + + + + S + + A E++ E+ + + P + + +
Sbjct: 1225 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1284
Query: 497 PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
+ GRV+F N YR VL++++ +++ G+ +VG +G+GKSS L
Sbjct: 1285 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1343
Query: 556 YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
G +++DG I+ L I+++ Q+PVLF+ S+ N+ PF E
Sbjct: 1344 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1397
Query: 611 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
V + + A+ F+ L D E E G LS GQ+Q V +ARAL+R +L+LDEAT
Sbjct: 1398 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1457
Query: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
+A+D E++ LIQ I + TVL IAHRL+T+ ++VLDKG + + G LL Q
Sbjct: 1458 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1517
Query: 731 GGLYAKLVQ 739
GL+ + +
Sbjct: 1518 RGLFYSMAK 1526
Score = 112 bits (281), Expect = 1e-24
Identities = 117/507 (23%), Positives = 231/507 (45%), Gaps = 56/507 (11%)
Query: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
R+ + ++R + S + G++++ ++ D DL + IN+ ++V
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452
Query: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
+ +++ L+ S++ + ++M+ N + K Y+ + ++ + N E
Sbjct: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508
Query: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
++ +K ++ +A E + L Q+ K+ +K A +A + W L+ + +Y
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568
Query: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
+ ++ Q +L F I F L + V S ++Q + +++ F+ +
Sbjct: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623
Query: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTAL 537
L PD +E R + N TFT+ R L ++FS+ G + A+
Sbjct: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAV 676
Query: 538 VGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSIT 597
VG G GKSS ++ L G V + G ++ V Q+ + S+
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLR 723
Query: 598 DNISYG--LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMAR 655
+NI +G L + V++A + L G TE GEKG LSGGQKQRV++AR
Sbjct: 724 ENILFGCQLEEPYYRSVIQACALLPD---LEILPSGDRTEIGEKGVNLSGGQKQRVSLAR 780
Query: 656 ALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVEHAHLIVV 712
A+ N + + D+ SA+DA +++ + I G L+ T +++ H +S + +I+V
Sbjct: 781 AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV 840
Query: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
+ G++ + G++Q+LLA+ G +A+ ++
Sbjct: 841 MSGGKISEMGSYQELLARDGAFAEFLR 867
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 154 bits (388), Expect = 4e-37
Identities = 145/588 (24%), Positives = 256/588 (43%), Gaps = 55/588 (9%)
Query: 187 FLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQF--STAVVIVCLLAIGSSFAAG 244
+L + FFL++ + L + AID + + + +T G S G
Sbjct: 985 YLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCG 1044
Query: 245 IRGGIFTLIFARLNIR---------LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTM 295
GIF + L + L + L ++ FFD G +++R ++DT +
Sbjct: 1045 --AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNI 1102
Query: 296 VSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSK 355
+ + + R+T+ + M S + + LV + + KY++ SK
Sbjct: 1103 IDQHIPPTLESLTRSTLLCLSAIG-MISYATPVFLVALLPLGVAFYFIQ---KYFRVASK 1158
Query: 356 EVQNA--------LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAA 407
++Q L S TAE + T+R+F +E R Q++ +L
Sbjct: 1159 DLQELDDSTQLPLLCHFSETAE----GLTTIRAFRHET-------RFKQRMLELTDTNNI 1207
Query: 408 AYMYYVWGSGLTLLVVQVSILYYGGHLV-------ISGQMTSGNLIAFIIYEFVLGDCME 460
AY++ + ++V Y G +V ISG SG + ++Y + + +
Sbjct: 1208 AYLFLSAANRW----LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1263
Query: 461 SVGSVYSGLMQGVGAAEKVFEFIDRQPTMVH---DGSLAPDHL--EGRVDFENVTFTYRT 515
V + L +GA +KV F+ + D S P+H EG + ++ Y
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN 1323
Query: 516 RPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDH 575
VL++V + PG+ + G +GSGKSS + G++++DG IS
Sbjct: 1324 NLKP-VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1382
Query: 576 KYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
L +S++ Q+P+LF+ SI N+ + + EA + A + L G
Sbjct: 1383 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTD-DRLWEALEIAQLKNMVKSLPGGLDAV 1441
Query: 636 TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVL 695
E G S GQ+Q +ARA VR +LI+DEAT+++D +E ++Q+ + TV+
Sbjct: 1442 VTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVV 1501
Query: 696 IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQM 742
IAHR+ T+ A L++V+ +G +++ T + LLAQ G++A V+ M
Sbjct: 1502 TIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVRADM 1549
Score = 97.8 bits (242), Expect = 3e-20
Identities = 69/211 (32%), Positives = 114/211 (54%), Gaps = 12/211 (5%)
Query: 522 LQNVSFSLSPGKVTALVGPSGSGKSSCV-NILENFYPLEGG---RVLLDGKPISAYDHKY 577
L N+ + G++T +VG G GKSS + IL LEG + + +P
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 578 LHRVISLVSQEPVLFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
++ +Q+P L ++ +NI++G P ++ V +A + I L G TE
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTE 804
Query: 636 TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQ--KH 692
GE+G LSGGQ+QR+ +ARAL +N ++ LD+ SALD S++L+Q+ I LQ K
Sbjct: 805 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 864
Query: 693 TVLIIAHRLSTVEHAHLIVVLDKGRVVQQGT 723
T++++ H+L + HA I+ + G V+++GT
Sbjct: 865 TLVLVTHKLQYLTHADWIIAMKDGSVLREGT 895
>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
sapiens]
Length = 1464
Score = 151 bits (382), Expect = 2e-36
Identities = 139/533 (26%), Positives = 249/533 (46%), Gaps = 46/533 (8%)
Query: 232 VCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTS 291
+C L FAAG TL R L R L++ T FF+ TG +++R +S
Sbjct: 952 LCTLLRAVLFAAGTLQAAATLH--------RRLLHRVLMAPVT-FFNATPTGRILNRFSS 1002
Query: 292 DTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS-LSWQLSLVTFMGFPIIMMVSNIYGKYY 350
D D + +N+ L N + G++ + S L W L L+ P+ +M ++ ++Y
Sbjct: 1003 DVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLP----PLSIMYYHVQ-RHY 1057
Query: 351 KRLSKEVQN----ALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
+ S+E++ L+ + +T++ + +R+ E LR L+ + +
Sbjct: 1058 RASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATS 1117
Query: 407 AAYMY-----YVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMES 461
A + + G+ + + ++++ + G G + + Y L +
Sbjct: 1118 ATMQWLDIRLQLMGAAVVSAIAGIALVQHQ-----QGLANPGLVGLSLSYALSLTGLLSG 1172
Query: 462 VGSVYSGLMQGVGAAEKVFEFI-------DRQPTMVHDGSLAPDHLEGRVDFENVTFTYR 514
+ S ++ + + E++ E+ QP + G L +G V+F++V YR
Sbjct: 1173 LVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLT----QGGVEFQDVVLAYR 1228
Query: 515 TRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYD 574
L V+F + PG+ +VG +GSGKSS + +L GRVLLDG S +
Sbjct: 1229 P-GLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLE 1287
Query: 575 HKYLHRVISLVSQEPVLFARSITDNIS-YGLPTVPFEMVVEAAQKANAHGFIMELQDGYS 633
L ++++ QEP LF+ ++ +N+ GL + + A K ++ G
Sbjct: 1288 LAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHK---DRALWQALKQCHLSEVITSMGGLD 1344
Query: 634 TETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHT 693
E GE G LS GQ+Q + +ARAL+ + +L +DEAT+++D +++ L+QQ I T
Sbjct: 1345 GELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKT 1404
Query: 694 VLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQMLGL 745
VL IAHRL+T+ ++ ++VL GRVV+ + L Q L+ +L+Q G+
Sbjct: 1405 VLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGV 1457
Score = 91.7 bits (226), Expect = 2e-18
Identities = 60/198 (30%), Positives = 102/198 (51%), Gaps = 12/198 (6%)
Query: 532 GKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVL 591
G + +VG G GKSS + + G V + G L + L +QEP +
Sbjct: 598 GMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQEPWI 647
Query: 592 FARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRV 651
+I DNI +G T ++ E + + + L G TE GEKG LSGGQ+ R+
Sbjct: 648 QFATIRDNILFG-KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARI 706
Query: 652 AMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLI 710
A+ARA+ + + +LD+ +A+DA+ + +L+ + I G L T L+ HR +E A +
Sbjct: 707 ALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAV 766
Query: 711 VVLDKGRVVQQGTHQQLL 728
++++ GR+++ G ++L
Sbjct: 767 LLMEAGRLIRAGPPSEIL 784
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 147 bits (372), Expect = 3e-35
Identities = 145/584 (24%), Positives = 254/584 (43%), Gaps = 55/584 (9%)
Query: 187 FLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQF--STAVVIVCLLAIGSSFAAG 244
+L + FFL++ + L + AID + + + +T G S G
Sbjct: 949 YLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCG 1008
Query: 245 IRGGIFTLIFARLNIR---------LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTM 295
GIF + L + L + L ++ FFD G +++R ++DT +
Sbjct: 1009 --AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNI 1066
Query: 296 VSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSK 355
+ + + R+T+ + M S + + LV + + KY++ SK
Sbjct: 1067 IDQHIPPTLESLTRSTLLCLSAIG-MISYATPVFLVALLPLGVAFYFIQ---KYFRVASK 1122
Query: 356 EVQNA--------LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAA 407
++Q L S TAE + T+R+F +E R Q++ +L
Sbjct: 1123 DLQELDDSTQLPLLCHFSETAE----GLTTIRAFRHET-------RFKQRMLELTDTNNI 1171
Query: 408 AYMYYVWGSGLTLLVVQVSILYYGGHLV-------ISGQMTSGNLIAFIIYEFVLGDCME 460
AY++ + ++V Y G +V ISG SG + ++Y + + +
Sbjct: 1172 AYLFLSAANRW----LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1227
Query: 461 SVGSVYSGLMQGVGAAEKVFEFIDRQPTMVH---DGSLAPDHL--EGRVDFENVTFTYRT 515
V + L +GA +KV F+ + D S P+H EG + ++ Y
Sbjct: 1228 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN 1287
Query: 516 RPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDH 575
VL++V + PG+ + G +GSGKSS + G++++DG IS
Sbjct: 1288 NLKP-VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1346
Query: 576 KYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
L +S++ Q+P+LF+ SI N+ + + EA + A + L G
Sbjct: 1347 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTD-DRLWEALEIAQLKNMVKSLPGGLDAV 1405
Query: 636 TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVL 695
E G S GQ+Q +ARA VR +LI+DEAT+++D +E ++Q+ + TV+
Sbjct: 1406 VTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVV 1465
Query: 696 IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLA-QGGLYAKLV 738
IAHR+S++ A L++V +G +V+ T LLA + GL++ LV
Sbjct: 1466 TIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509
Score = 97.8 bits (242), Expect = 3e-20
Identities = 69/211 (32%), Positives = 114/211 (54%), Gaps = 12/211 (5%)
Query: 522 LQNVSFSLSPGKVTALVGPSGSGKSSCV-NILENFYPLEGG---RVLLDGKPISAYDHKY 577
L N+ + G++T +VG G GKSS + IL LEG + + +P
Sbjct: 652 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 711
Query: 578 LHRVISLVSQEPVLFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
++ +Q+P L ++ +NI++G P ++ V +A + I L G TE
Sbjct: 712 NRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTE 768
Query: 636 TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQ--KH 692
GE+G LSGGQ+QR+ +ARAL +N ++ LD+ SALD S++L+Q+ I LQ K
Sbjct: 769 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 828
Query: 693 TVLIIAHRLSTVEHAHLIVVLDKGRVVQQGT 723
T++++ H+L + HA I+ + G V+++GT
Sbjct: 829 TLVLVTHKLQYLTHADWIIAMKDGSVLREGT 859
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 147 bits (372), Expect = 3e-35
Identities = 145/584 (24%), Positives = 254/584 (43%), Gaps = 55/584 (9%)
Query: 187 FLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQF--STAVVIVCLLAIGSSFAAG 244
+L + FFL++ + L + AID + + + +T G S G
Sbjct: 985 YLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCG 1044
Query: 245 IRGGIFTLIFARLNIR---------LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTM 295
GIF + L + L + L ++ FFD G +++R ++DT +
Sbjct: 1045 --AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNI 1102
Query: 296 VSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSK 355
+ + + R+T+ + M S + + LV + + KY++ SK
Sbjct: 1103 IDQHIPPTLESLTRSTLLCLSAIG-MISYATPVFLVALLPLGVAFYFIQ---KYFRVASK 1158
Query: 356 EVQNA--------LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAA 407
++Q L S TAE + T+R+F +E R Q++ +L
Sbjct: 1159 DLQELDDSTQLPLLCHFSETAE----GLTTIRAFRHET-------RFKQRMLELTDTNNI 1207
Query: 408 AYMYYVWGSGLTLLVVQVSILYYGGHLV-------ISGQMTSGNLIAFIIYEFVLGDCME 460
AY++ + ++V Y G +V ISG SG + ++Y + + +
Sbjct: 1208 AYLFLSAANRW----LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1263
Query: 461 SVGSVYSGLMQGVGAAEKVFEFIDRQPTMVH---DGSLAPDHL--EGRVDFENVTFTYRT 515
V + L +GA +KV F+ + D S P+H EG + ++ Y
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN 1323
Query: 516 RPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDH 575
VL++V + PG+ + G +GSGKSS + G++++DG IS
Sbjct: 1324 NLKP-VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1382
Query: 576 KYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
L +S++ Q+P+LF+ SI N+ + + EA + A + L G
Sbjct: 1383 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTD-DRLWEALEIAQLKNMVKSLPGGLDAV 1441
Query: 636 TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVL 695
E G S GQ+Q +ARA VR +LI+DEAT+++D +E ++Q+ + TV+
Sbjct: 1442 VTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVV 1501
Query: 696 IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLA-QGGLYAKLV 738
IAHR+S++ A L++V +G +V+ T LLA + GL++ LV
Sbjct: 1502 TIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545
Score = 97.8 bits (242), Expect = 3e-20
Identities = 69/211 (32%), Positives = 114/211 (54%), Gaps = 12/211 (5%)
Query: 522 LQNVSFSLSPGKVTALVGPSGSGKSSCV-NILENFYPLEGG---RVLLDGKPISAYDHKY 577
L N+ + G++T +VG G GKSS + IL LEG + + +P
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747
Query: 578 LHRVISLVSQEPVLFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
++ +Q+P L ++ +NI++G P ++ V +A + I L G TE
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTE 804
Query: 636 TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQ--KH 692
GE+G LSGGQ+QR+ +ARAL +N ++ LD+ SALD S++L+Q+ I LQ K
Sbjct: 805 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 864
Query: 693 TVLIIAHRLSTVEHAHLIVVLDKGRVVQQGT 723
T++++ H+L + HA I+ + G V+++GT
Sbjct: 865 TLVLVTHKLQYLTHADWIIAMKDGSVLREGT 895
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 146 bits (369), Expect = 6e-35
Identities = 126/520 (24%), Positives = 235/520 (45%), Gaps = 32/520 (6%)
Query: 235 LAIGSSFAAGIRGGIFTLIFARLNIR--------LRNCLFRSLVSQETSFFDENRTGDLI 286
L +G A GI G ++ A L L + + SFFD +G ++
Sbjct: 1010 LRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRIL 1069
Query: 287 SRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIY 346
+ + D +V ++++ I + L + +V + + + ++V + +V Y
Sbjct: 1070 NCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFY 1129
Query: 347 GKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
++L + + + + ET++ +R++ N + E+ K++ +
Sbjct: 1130 AATSRQLKRLESVSRSPIYSHFSETVTGASVIRAY-NRSRDFEIISDT-----KVDANQR 1183
Query: 407 AAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQMTSGNLIAFII-YEFVLGDCMESV 462
+ Y Y + L++ V V +L+ VI + L+ + Y + + +
Sbjct: 1184 SCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWM 1243
Query: 463 GSVYSGLMQGVGAAEKVFEF--IDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQ 520
+ S L + A E+V E+ + + V +GS P+ R + E ++ R RP
Sbjct: 1244 IRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLD 1303
Query: 521 -VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLH 579
VL+++S + G+ +VG +G+GKSS L G + +DG ++ L
Sbjct: 1304 LVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLR 1363
Query: 580 RVISLVSQEPVLFARSITDNISYGLPTVPFEMVVE-----AAQKANAHGFIMELQDGYST 634
++++ Q+P+LF+ ++ N+ PF E A + ++ H F+ G
Sbjct: 1364 SQLTIIPQDPILFSGTLRMNLD------PFGSYSEEDIWWALELSHLHTFVSSQPAGLDF 1417
Query: 635 ETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTV 694
+ E G LS GQ+Q V +ARAL+R +L+LDEAT+A+D E++ LIQ I TV
Sbjct: 1418 QCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTV 1477
Query: 695 LIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLY 734
L IAHRL+T+ ++VLDKG V + + L+A G++
Sbjct: 1478 LTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517
Score = 96.7 bits (239), Expect = 7e-20
Identities = 125/590 (21%), Positives = 260/590 (44%), Gaps = 85/590 (14%)
Query: 174 LQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIV- 232
+Q LLS+ P + +++ + P + G + G++ SM Q ++++
Sbjct: 320 IQDLLSFINPQL-------LSILIRFISNPMAPSWWGFLVAGLMFLCSMMQ---SLILQH 369
Query: 233 ---CLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRL 289
+ G F GI G I+ R + + N + R+ + G++++ +
Sbjct: 370 YYHYIFVTGVKFRTGIMGVIY-----RKALVITNSVKRA-----------STVGEIVNLM 413
Query: 290 TSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIY 346
+ D DL + +N+ +++ + F+ WQ S++ + F ++++ N
Sbjct: 414 SVDAQRFMDL-APFLNLLWSAPLQIILAIYFL----WQNLGPSVLAGVAFMVLLIPLNGA 468
Query: 347 GKYYKRLSKEVQNALARAS-NTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK--LNR 403
R + Q L + E ++ +K ++ +A E +L++++ + + L
Sbjct: 469 VAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPS----FLKQVEGIRQGELQL 524
Query: 404 KEAAAYMY----YVWGSG---LTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLG 456
AAY++ + W +TL+ + V + Y + V+ + ++ F I L
Sbjct: 525 LRTAAYLHTTTTFTWMCSPFLVTLITLWVYV-YVDPNNVLDAEKAFVSVSLFNILRLPLN 583
Query: 457 DCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLAPDHLEGRVDFENVTFTY 513
+ + S L Q + +++ +F+ ++ P V +++P + + + TFT+
Sbjct: 584 ----MLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYA---ITIHSGTFTW 636
Query: 514 RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAY 573
+ L ++ + G + A+VGP G GKSS V+ L G+V + G
Sbjct: 637 -AQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS----- 690
Query: 574 DHKYLHRVISLVSQEPVLFARSITDNISYGLPTVP--FEMVVEAAQKANAHGFIMELQDG 631
++ V Q+ + ++ +N+ +G P ++ +EA + L G
Sbjct: 691 --------VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALL---ADLEMLPGG 739
Query: 632 YSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGN 688
TE GEKG LSGGQ+QRV++ARA+ + + +LD+ SA+D+ ++++ I G
Sbjct: 740 DQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGV 799
Query: 689 LQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLV 738
L T +++ H +S + I+VL G+V + G + LL + G +A +
Sbjct: 800 LAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFL 849
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 144 bits (362), Expect = 4e-34
Identities = 141/533 (26%), Positives = 241/533 (45%), Gaps = 48/533 (9%)
Query: 233 CLLAIG--SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLT 290
CL AIG +S AA + GG AR + L L +V SFF+ G L++R +
Sbjct: 805 CLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFS 858
Query: 291 SDTTMVSDLVSQNINVFLR---NTVKVTGVVVFMFSLSWQLSLVTFM---GFPIIMMVSN 344
+T V + + L ++V+ VV L+ L F+ GF + +VS+
Sbjct: 859 KETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 918
Query: 345 IYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRK 404
+L + + + + ET VR+F + ++ + +++
Sbjct: 919 C------QLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFP 972
Query: 405 EAAAYMYY-----VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDC 458
A + + G+GL ++L S S L+ F + + +
Sbjct: 973 RLVADRWLAANVELLGNGLVFAAATCAVL--------SKAHLSAGLVGFSVSAALQVTQT 1024
Query: 459 MESVGSVYSGLMQGVGAAEKVFEFID-------RQPTMVHDGSLAPDHLEGRVDFENVTF 511
++ V ++ L + + E++ ++ R PT + P G+++F++ F
Sbjct: 1025 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA---AQPPWPQGGQIEFQD--F 1079
Query: 512 TYRTRPHTQV-LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
R RP + +Q VSF + G+ +VG +G+GKSS + L G + +DG PI
Sbjct: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139
Query: 571 SAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQD 630
+ L IS++ Q+P+LF S+ N+ L E + A + + L
Sbjct: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKALVASLPG 1198
Query: 631 GYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ 690
+ ++G LS GQKQ + +ARAL+R +LILDEAT+A+D +E +Q +
Sbjct: 1199 QLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFA 1258
Query: 691 KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
+ TVL+IAHRL +V ++V+DKG+V + G+ QLLAQ GL+ +L Q L
Sbjct: 1259 QCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1311
Score = 102 bits (255), Expect = 1e-21
Identities = 118/520 (22%), Positives = 228/520 (43%), Gaps = 47/520 (9%)
Query: 257 LNIRLRNCL----FRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTV 312
L +RLR+ + +R +++ + + GD+++ ++ D +++ V ++L
Sbjct: 186 LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESV-----LYLNGLW 240
Query: 313 KVTGVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAE 369
+V F WQL S +T + + ++ N + K+ + + + + + A
Sbjct: 241 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFF--ISKKRNHHQEEQMRQKDSRAR 298
Query: 370 ETISAMKTVRSFANEEEEAEVYLRKLQ-QVYKLNRKEAAAYMYYVWGSGLTLLVVQVSIL 428
T S ++ ++ E R L + +L + ++ V + V+++
Sbjct: 299 LTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALV 358
Query: 429 YYGGH-LVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFI---D 484
+ H LV M + + +L + L+Q + +++ F+ +
Sbjct: 359 VFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE 418
Query: 485 RQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSG 544
P V S + + ++ TF + ++ L ++ ++ G + A+VGP G+G
Sbjct: 419 VDPGAVDSSSSGSAAGKDCITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAG 477
Query: 545 KSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGL 604
KSS ++ L G V ++G ++ V QE + S+ +N+ +G
Sbjct: 478 KSSLLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQ 524
Query: 605 PTVP--FEMVVEA-AQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNP 661
P E V+EA A + + F +G T GE+G LSGGQKQR+++ARA+ R
Sbjct: 525 ELDPPWLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKA 580
Query: 662 PVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRV 718
V +LD+ +ALDA +++ Q I G LQ T +++ H L + A I+VL G +
Sbjct: 581 AVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAI 640
Query: 719 VQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEP 758
+ G++Q+LL + G L+ + QP D G EP
Sbjct: 641 AEMGSYQELLQRKGALVCLLDQ---ARQP-GDRGEGETEP 676
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 143 bits (360), Expect = 7e-34
Identities = 141/533 (26%), Positives = 240/533 (45%), Gaps = 48/533 (9%)
Query: 233 CLLAIG--SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLT 290
CL AIG +S AA + GG AR + L L +V SFF+ G L++R +
Sbjct: 996 CLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFS 1049
Query: 291 SDTTMVSDLVSQNINVFLR---NTVKVTGVVVFMFSLSWQLSLVTFM---GFPIIMMVSN 344
+T V + + L ++V+ VV L+ L F+ GF + +VS+
Sbjct: 1050 KETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1109
Query: 345 IYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRK 404
+L + + + + ET VR+F + ++ + +++
Sbjct: 1110 C------QLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFP 1163
Query: 405 EAAAYMYY-----VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDC 458
A + + G+GL ++L S S L+ F + + +
Sbjct: 1164 RLVADRWLAANVELLGNGLVFAAATCAVL--------SKAHLSAGLVGFSVSAALQVTQT 1215
Query: 459 MESVGSVYSGLMQGVGAAEKVFEFID-------RQPTMVHDGSLAPDHLEGRVDFENVTF 511
++ V ++ L + + E++ ++ R PT + P G+++F + F
Sbjct: 1216 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA---AQPPWPQGGQIEFRD--F 1270
Query: 512 TYRTRPHTQV-LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
R RP + +Q VSF + G+ +VG +G+GKSS + L G + +DG PI
Sbjct: 1271 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1330
Query: 571 SAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQD 630
+ L IS++ Q+P+LF S+ N+ L E + A + + L
Sbjct: 1331 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKALVASLPG 1389
Query: 631 GYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ 690
+ ++G LS GQKQ + +ARAL+R +LILDEAT+A+D +E +Q +
Sbjct: 1390 QLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFA 1449
Query: 691 KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
+ TVL+IAHRL +V ++V+DKG+V + G+ QLLAQ GL+ +L Q L
Sbjct: 1450 QCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1502
Score = 102 bits (255), Expect = 1e-21
Identities = 118/520 (22%), Positives = 228/520 (43%), Gaps = 47/520 (9%)
Query: 257 LNIRLRNCL----FRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTV 312
L +RLR+ + +R +++ + + GD+++ ++ D +++ V ++L
Sbjct: 377 LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESV-----LYLNGLW 431
Query: 313 KVTGVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAE 369
+V F WQL S +T + + ++ N + K+ + + + + + A
Sbjct: 432 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFF--ISKKRNHHQEEQMRQKDSRAR 489
Query: 370 ETISAMKTVRSFANEEEEAEVYLRKLQ-QVYKLNRKEAAAYMYYVWGSGLTLLVVQVSIL 428
T S ++ ++ E R L + +L + ++ V + V+++
Sbjct: 490 LTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALV 549
Query: 429 YYGGH-LVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFI---D 484
+ H LV M + + +L + L+Q + +++ F+ +
Sbjct: 550 VFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE 609
Query: 485 RQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSG 544
P +V S + + + TF + ++ L ++ ++ G + A+VGP G+G
Sbjct: 610 VDPGVVDSSSSGSAAGKDCITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAG 668
Query: 545 KSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGL 604
KSS ++ L G V ++G ++ V QE + S+ +N+ +G
Sbjct: 669 KSSLLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQ 715
Query: 605 PTVP--FEMVVEA-AQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNP 661
P E V+EA A + + F +G T GE+G LSGGQKQR+++ARA+ R
Sbjct: 716 ELDPPWLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKA 771
Query: 662 PVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRV 718
V +LD+ +ALDA +++ Q I G LQ T +++ H L + A I+VL G +
Sbjct: 772 AVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAI 831
Query: 719 VQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEP 758
+ G++Q+LL + G L+ + QP D G EP
Sbjct: 832 AEMGSYQELLQRKGALVCLLDQ---ARQP-GDRGEGETEP 867
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 140 bits (354), Expect = 3e-33
Identities = 128/513 (24%), Positives = 242/513 (47%), Gaps = 45/513 (8%)
Query: 261 LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 320
L N +F S++ FFD N G +++R + D + DL+ F++ ++V GVV
Sbjct: 797 LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVV-- 854
Query: 321 MFSLSWQLSLVTFMGFPIIMM--VSNIYGKYYKRLSKEVQNALARASNTA----EETISA 374
S ++++ ++ P++ + + +Y+ S++V+ + + ++
Sbjct: 855 ----SVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQG 910
Query: 375 MKTVRSFANEEEEAEVYLRKLQQVYKLNRK-EAAAYMYYVWGSG-----LTLLVVQVSIL 428
+ T+R++ EE + Q+++ ++ + A+ ++ S L + I+
Sbjct: 911 LWTIRAYKAEE--------RCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVII 962
Query: 429 YYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPT 488
G L+++ + +G + + Y L + + + + + E+V E+ D +
Sbjct: 963 VAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKE 1022
Query: 489 MVHDGSLAPDHL---EGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 545
+ P EG + F+NV F Y + VL++++ + + +VG +G+GK
Sbjct: 1023 APWEYQKRPPPAWPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGK 1081
Query: 546 SSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLP 605
SS ++ L EG ++ +D + L + +S++ QEPVLF ++ N+
Sbjct: 1082 SSLISALFRLSEPEG-KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD---- 1136
Query: 606 TVPF-----EMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
PF E + A Q+ I +L TE E G+ S GQ+Q V +ARA++R
Sbjct: 1137 --PFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1194
Query: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
+LI+DEAT+ +D ++ LIQ+ I TVL IAHRL+T+ + I+VLD GR+ +
Sbjct: 1195 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254
Query: 721 QGTHQQLLA-QGGLYAKLVQRQMLGLQPAADFT 752
LL + L+ K+VQ+ LG AA T
Sbjct: 1255 YDEPYVLLQNKESLFYKMVQQ--LGKAEAAALT 1285
Score = 128 bits (322), Expect = 2e-29
Identities = 131/571 (22%), Positives = 257/571 (45%), Gaps = 44/571 (7%)
Query: 186 AFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQ--FSTAVVIVCLLAIGSSFAA 243
++LV F LI + + P + G+ I+ MD +TA +L + A
Sbjct: 91 SYLVLGIFTLIEES-AKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILA 149
Query: 244 GIRGGIFTLIFA---RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
+ F + RL + + + ++R + + TG +++ L++D
Sbjct: 150 ILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQ-- 207
Query: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQ---LSLVTFMGFPIIMM-VSNIYGKYYKRLSKE 356
+ VFL + + +L W +S + M II++ + + +GK + L +
Sbjct: 208 ---VTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSK 264
Query: 357 VQNALARASNTAEETISAMKTVRSFANEEEEAEVY--LRKLQQVYKLNRKEAAAYMYYVW 414
T E I+ ++ ++ +A E+ + + LRK +++ K+ R M
Sbjct: 265 TATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRK-KEISKILRSSCLRGMNLAS 323
Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGN--LIAFIIYEFVLGDCMESVGSVYSGLMQG 472
+ ++V V+ Y V+ G + + + +A +Y V S + +
Sbjct: 324 FFSASKIIVFVTFTTY----VLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379
Query: 473 VGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
+ + ++ F+ + L D + V ++ T + T LQ +SF++ PG
Sbjct: 380 IVSIRRIQTFLLLDEISQRNRQLPSDGKK-MVHVQDFTAFWDKASETPTLQGLSFTVRPG 438
Query: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
++ A+VGP G+GKSS ++ + G V + G+ I+ VSQ+P +F
Sbjct: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVF 485
Query: 593 ARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQR 650
+ ++ NI +G +E V++A + L+DG T G++G LSGGQK R
Sbjct: 486 SGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGDRGTTLSGGQKAR 542
Query: 651 VAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHL 709
V +ARA+ ++ + +LD+ SA+DAE S +L + I L + +++ H+L ++ A
Sbjct: 543 VNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQ 602
Query: 710 IVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
I++L G++VQ+GT+ + L G + L+++
Sbjct: 603 ILILKDGKMVQKGTYTEFLKSGIDFGSLLKK 633
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.401
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,330,699
Number of Sequences: 37866
Number of extensions: 1109504
Number of successful extensions: 3823
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 88
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3473
Number of HSP's gapped (non-prelim): 214
length of query: 766
length of database: 18,247,518
effective HSP length: 110
effective length of query: 656
effective length of database: 14,082,258
effective search space: 9237961248
effective search space used: 9237961248
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.