Guide to the Human Genome
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Search of human proteins with 45243524

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP),
member 9 isoform 1 [Homo sapiens]
         (766 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ...  1503   0.0  
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member...  1503   0.0  
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ...  1399   0.0  
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is...   479   e-135
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho...   464   e-130
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is...   447   e-125
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo...   403   e-112
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ...   367   e-101
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member...   318   2e-86
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa...   317   2e-86
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B...   314   2e-85
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C...   314   2e-85
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A...   314   2e-85
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ...   280   5e-75
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa...   234   3e-61
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s...   214   2e-55
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member...   168   2e-41
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform...   163   6e-40
gi|134142345 ATP-binding cassette, sub-family C, member 1 isofor...   162   1e-39
gi|134142342 ATP-binding cassette, sub-family C, member 1 isofor...   162   1e-39
gi|134142340 ATP-binding cassette, sub-family C, member 1 isofor...   162   1e-39
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor...   162   1e-39
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor...   154   4e-37
gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo ...   151   2e-36
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor...   147   3e-35
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor...   147   3e-35
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ...   146   6e-35
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]           144   4e-34
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor...   143   7e-34
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor...   140   3e-33

>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score = 1503 bits (3891), Expect = 0.0
 Identities = 766/766 (100%), Positives = 766/766 (100%)

Query: 1   MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60
           MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL
Sbjct: 1   MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60

Query: 61  LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120
           LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF
Sbjct: 61  LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120

Query: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180
           VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY
Sbjct: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180

Query: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240
           TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS
Sbjct: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240

Query: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
           FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV
Sbjct: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300

Query: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360
           SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA
Sbjct: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360

Query: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420
           LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL
Sbjct: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420

Query: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480
           LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF
Sbjct: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480

Query: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540
           EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP
Sbjct: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540

Query: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600
           SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI
Sbjct: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600

Query: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
           SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN
Sbjct: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660

Query: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
           PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ
Sbjct: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720

Query: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766
           QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
Sbjct: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766


>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 1 [Homo sapiens]
          Length = 766

 Score = 1503 bits (3891), Expect = 0.0
 Identities = 766/766 (100%), Positives = 766/766 (100%)

Query: 1   MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60
           MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL
Sbjct: 1   MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60

Query: 61  LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120
           LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF
Sbjct: 61  LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120

Query: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180
           VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY
Sbjct: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180

Query: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240
           TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS
Sbjct: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240

Query: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
           FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV
Sbjct: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300

Query: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360
           SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA
Sbjct: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360

Query: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420
           LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL
Sbjct: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420

Query: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480
           LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF
Sbjct: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480

Query: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540
           EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP
Sbjct: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540

Query: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600
           SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI
Sbjct: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600

Query: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
           SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN
Sbjct: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660

Query: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
           PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ
Sbjct: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720

Query: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766
           QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
Sbjct: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766


>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
           isoform 2 [Homo sapiens]
          Length = 723

 Score = 1399 bits (3621), Expect = 0.0
 Identities = 723/766 (94%), Positives = 723/766 (94%), Gaps = 43/766 (5%)

Query: 1   MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60
           MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL
Sbjct: 1   MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCL 60

Query: 61  LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120
           LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF
Sbjct: 61  LLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALF 120

Query: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180
           VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY
Sbjct: 121 VWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSY 180

Query: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240
           TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS
Sbjct: 181 TKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSS 240

Query: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
           FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV
Sbjct: 241 FAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300

Query: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360
           SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA
Sbjct: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNA 360

Query: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTL 420
           LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSG   
Sbjct: 361 LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSG--- 417

Query: 421 LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVF 480
                                                   SVGSVYSGLMQGVGAAEKVF
Sbjct: 418 ----------------------------------------SVGSVYSGLMQGVGAAEKVF 437

Query: 481 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 540
           EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP
Sbjct: 438 EFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGP 497

Query: 541 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 600
           SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI
Sbjct: 498 SGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNI 557

Query: 601 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
           SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN
Sbjct: 558 SYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 617

Query: 661 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
           PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ
Sbjct: 618 PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 677

Query: 721 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 766
           QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA
Sbjct: 678 QGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA 723


>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
           isoform 1 [Homo sapiens]
          Length = 703

 Score =  479 bits (1234), Expect = e-135
 Identities = 269/660 (40%), Positives = 405/660 (61%), Gaps = 31/660 (4%)

Query: 89  VCLFVGIYAMVKLLLFSEVRRP----IRDPWFWALFVWTYISLGASFLLWWLLSTVRPGT 144
           +CL   +   ++ L+    R P       PW W L     +  GA+ L W L + + P  
Sbjct: 69  LCLATPLTVSLRALVAGASRAPPARVASAPWSWLL-----VGYGAAGLSWSLWAVLSP-- 121

Query: 145 QALEPGAATEAEGFPGSGRPPPEQASGATLQ-KLLSYTKPDVAFLVAASFFLIVAALGET 203
                         PG+     +Q +   L  +LL  ++PD+  LVAA FFL++A LGET
Sbjct: 122 --------------PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGET 167

Query: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
            +P+Y+GR ID +        F++A+  +CL + GSS +AG RGG FT   +R+N+R+R 
Sbjct: 168 LIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIRE 227

Query: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
            LF SL+ Q+  FF E +TG+L SRL+SDTT++S+ +  N NV LR+ VKV G+  FM S
Sbjct: 228 QLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLS 287

Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
           +S +L+L++ +  P  +    +Y   ++ + +E+Q+A+ARA     E +  ++TVRSF  
Sbjct: 288 ISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGA 347

Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443
           EE E   Y   L+Q  +L  +       Y+    +  L VQ+ +L  G   +  G++T G
Sbjct: 348 EEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407

Query: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGR 503
           +L++F+IY+  +G  ++++  +Y  ++  VGAAEKVF ++DRQP +   G+LAP  L+G 
Sbjct: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGV 467

Query: 504 VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRV 563
           V F++V+F Y  RP   VL+ ++F+L PG+VTALVGP+GSGKS+   +L+N Y   GG+V
Sbjct: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527

Query: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
           LLD KPIS Y+H YLH  +  V QEPVLF+ S+ +NI+YGL +   + V+ AAQ A+A  
Sbjct: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587

Query: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 683
           FI E++ G  T+ GEKG+QL+ GQKQR+A+ARALVR+P VLILDEATSALD + E  +Q 
Sbjct: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQD 647

Query: 684 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
               +    TVL+IAHRL  V+ AH I+VL +G++ +     QL     LY++LVQ++++
Sbjct: 648 --WNSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEGQDLYSRLVQQRLM 702


>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
           sapiens]
          Length = 808

 Score =  464 bits (1193), Expect = e-130
 Identities = 242/579 (41%), Positives = 377/579 (65%), Gaps = 3/579 (0%)

Query: 164 PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMD 223
           P  +  SG  +++LL     +   L      +++++LGE  +P++TGR  D I+   S D
Sbjct: 223 PGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSAD 282

Query: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTG 283
            F+  + ++ +L I S+    +  GI+      ++  L+  +F +++ QET FF +N+TG
Sbjct: 283 TFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTG 342

Query: 284 DLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVS 343
           +++SR+T DT+ +SD +S+N+++FL   V+   ++  M   S  L++VT +  P++ ++ 
Sbjct: 343 NIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLP 402

Query: 344 NIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNR 403
              GK+Y+ L  +V+ +LA++S  A E +SAM TVRSFANEE EA+ +  KLQ++  LN+
Sbjct: 403 KKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQ 462

Query: 404 KEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVG 463
           KEA AY    W + ++ ++++V ILY GG LV SG ++SGNL+ F++Y+      +E + 
Sbjct: 463 KEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLL 522

Query: 464 SVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQ 523
           S+Y  + + VG++EK+FE++DR P     G L P HLEG V F++V+F Y  RP   VLQ
Sbjct: 523 SIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQ 582

Query: 524 NVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVIS 583
            ++F+L PG+VTALVGP+GSGKS+   +L+N Y   GG++LLDGKP+  Y+H+YLHR ++
Sbjct: 583 GLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVA 642

Query: 584 LVSQEPVLFARSITDNISYGLPTVP-FEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQ 642
            V QEP +F RS+ +NI+YGL   P  E +  AA K+ AH FI  L  GY TE  E G+Q
Sbjct: 643 AVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQ 702

Query: 643 LSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKH--TVLIIAHR 700
           LSGGQ+Q VA+ARAL+R P VLILD+ATSALDA S+  ++Q ++ + +++  +VL+I   
Sbjct: 703 LSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQH 762

Query: 701 LSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
           LS VE A  I+ L+ G + + GTHQQL+ + G Y  +VQ
Sbjct: 763 LSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQ 801


>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
           isoform 2 [Homo sapiens]
          Length = 653

 Score =  447 bits (1151), Expect = e-125
 Identities = 246/595 (41%), Positives = 367/595 (61%), Gaps = 26/595 (4%)

Query: 89  VCLFVGIYAMVKLLLFSEVRRP----IRDPWFWALFVWTYISLGASFLLWWLLSTVRPGT 144
           +CL   +   ++ L+    R P       PW W L     +  GA+ L W L + + P  
Sbjct: 69  LCLATPLTVSLRALVAGASRAPPARVASAPWSWLL-----VGYGAAGLSWSLWAVLSP-- 121

Query: 145 QALEPGAATEAEGFPGSGRPPPEQASGATLQ-KLLSYTKPDVAFLVAASFFLIVAALGET 203
                         PG+     +Q +   L  +LL  ++PD+  LVAA FFL++A LGET
Sbjct: 122 --------------PGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGET 167

Query: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
            +P+Y+GR ID +        F++A+  +CL + GSS +AG RGG FT   +R+N+R+R 
Sbjct: 168 LIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIRE 227

Query: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
            LF SL+ Q+  FF E +TG+L SRL+SDTT++S+ +  N NV LR+ VKV G+  FM S
Sbjct: 228 QLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLS 287

Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
           +S +L+L++ +  P  +    +Y   ++ + +E+Q+A+ARA     E +  ++TVRSF  
Sbjct: 288 ISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGA 347

Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443
           EE E   Y   L+Q  +L  +       Y+    +  L VQ+ +L  G   +  G++T G
Sbjct: 348 EEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407

Query: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGR 503
           +L++F+IY+  +G  ++++  +Y  ++  VGAAEKVF ++DRQP +   G+LAP  L+G 
Sbjct: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGV 467

Query: 504 VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRV 563
           V F++V+F Y  RP   VL+ ++F+L PG+VTALVGP+GSGKS+   +L+N Y   GG+V
Sbjct: 468 VKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQV 527

Query: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
           LLD KPIS Y+H YLH  +  V QEPVLF+ S+ +NI+YGL +   + V+ AAQ A+A  
Sbjct: 528 LLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADD 587

Query: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESE 678
           FI E++ G  T+ GEKG+QL+ GQKQR+A+ARALVR+P VLILDEATSALD + E
Sbjct: 588 FIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCE 642


>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
           sapiens]
          Length = 738

 Score =  403 bits (1036), Expect = e-112
 Identities = 235/595 (39%), Positives = 364/595 (61%), Gaps = 14/595 (2%)

Query: 159 PGS-GRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIV 217
           PG  GR  P  A     +KLL    P+   L AA  FL ++++     P++ G+ ID I 
Sbjct: 141 PGDKGRLRPAAAGLPEARKLLGLAYPERRRLAAAVGFLTMSSVISMSAPFFLGKIIDVIY 200

Query: 218 IQKSMDQFSTAVVIVCLLAIGSSFAAG-----IRGGIFTLIFARLNIRLRNCLFRSLVSQ 272
              ++D +S  +  +CL  + + F  G     IR  +      R+  RLR  LF S++ Q
Sbjct: 201 TNPTVD-YSDNLTRLCL-GLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQ 258

Query: 273 ETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVT 332
           E +FFD+ RTG+LI+RL+SDT ++   V++N++  LR   + +  +  MF +S  L+   
Sbjct: 259 EVAFFDKTRTGELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFV 318

Query: 333 FMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYL 392
               P + +++ IYG+Y ++L+K  Q++LA+A+  AEE I  ++TVR+F  E  E E Y 
Sbjct: 319 LSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYA 378

Query: 393 RKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYE 452
            K+  V +L RKEA A   +   +GL+  ++ +S+LY GG L+ S  MT G L +F++Y 
Sbjct: 379 SKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYA 438

Query: 453 FVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLEGRVDFENVT 510
           F +G  +  + S YS LM+G+GA  +++E ++R+P +  +    L     +G ++F+NV 
Sbjct: 439 FWVGISIGGLSSFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVH 498

Query: 511 FTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
           F Y  RP   + Q+ S S+  G VTALVGPSGSGKS+ +++L   Y    G + LDG  I
Sbjct: 499 FAYPARPEVPIFQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDI 558

Query: 571 SAYDHKYLHRVISLVSQEPVLFARSITDNISYGL---PTVPFEMVVEAAQKANAHGFIME 627
              +  +L   I  VSQEP+LF+ SI +NI+YG     +V  E +   A+ ANA  FI  
Sbjct: 559 RQLNPVWLRSKIGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRN 618

Query: 628 LQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHG 687
              G++T  GEKG  LSGGQKQR+A+ARAL++NP +L+LDEATSALDAE+EYL+Q+A+  
Sbjct: 619 FPQGFNTVVGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDR 678

Query: 688 NLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQ 741
            +   TVL+IAHRLST+++A+++ VLD+G++ + G H++LL++  G+Y KL+ +Q
Sbjct: 679 LMDGRTVLVIAHRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQ 733


>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
           sapiens]
          Length = 718

 Score =  367 bits (941), Expect = e-101
 Identities = 220/603 (36%), Positives = 342/603 (56%), Gaps = 11/603 (1%)

Query: 151 AATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG 210
           A  EAE  P +   P    S    +    +  P +  L  A    + AAL    +P   G
Sbjct: 94  ALCEAEEAPPASSTPHVVGSRFNWKLFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLG 153

Query: 211 RAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRG----GIFTLIF---ARLNIRLRN 263
           + ++ +V + + D   + +     L+       G++G    G   L+     R+ + +R 
Sbjct: 154 QLVE-VVAKYTRDHVGSFMTESQNLSTHLLILYGVQGLLTFGYLVLLSHVGERMAVDMRR 212

Query: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
            LF SL+ Q+ +FFD N+TG L+SRLT+D           I+  LR+  +V G +V +  
Sbjct: 213 ALFSSLLRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSM 272

Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
           LS +L+L+  +  P +M V  + G   ++LS++ Q  +ARA   A+E +  ++TVR+FA 
Sbjct: 273 LSTRLTLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAM 332

Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSG 443
           E+ E E Y  +L+       +       +   S +    + +  L+ GG LV   Q+T G
Sbjct: 333 EQREEERYGAELEACRCRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGG 392

Query: 444 NLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGS--LAPDHLE 501
           +L++F++    +   M ++  ++  +++G+ A  +VFE++   P +   G   +  + L 
Sbjct: 393 DLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLR 452

Query: 502 GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGG 561
           G V F+NV F+Y  RP  +VL++ + +L PGK+ ALVG SG GK++  ++LE FY    G
Sbjct: 453 GSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAG 512

Query: 562 RVLLDGKPISAYDHKYLH-RVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 620
            V+LDG+ +   D  +L  +V+  +SQEPVLF  +I +NI +G      E V  AA++AN
Sbjct: 513 VVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREAN 572

Query: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
           AH FI    +GY+T  GE+G  LSGGQKQR+A+ARAL++ P VLILDEATSALDAESE +
Sbjct: 573 AHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERV 632

Query: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
           +Q+A+       TVL+IAHRLSTV  AH IVV+  GRV + GTH++LL +GGLYA+L++R
Sbjct: 633 VQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRR 692

Query: 741 QML 743
           Q L
Sbjct: 693 QAL 695


>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
            [Homo sapiens]
          Length = 1321

 Score =  318 bits (814), Expect = 2e-86
 Identities = 193/587 (32%), Positives = 316/587 (53%), Gaps = 15/587 (2%)

Query: 164  PPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTG--RAIDGIVIQKS 221
            P  E+   A ++++L ++ P+  +++  S   + AA+  T  P Y      I G      
Sbjct: 731  PVQEEVEPAPVRRILKFSAPEWPYMLVGS---VGAAVNGTVTPLYAFLFSQILGTFSIPD 787

Query: 222  MDQFSTAVVIVCLLAIG----SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFF 277
             ++  + +  VCLL +     S F   ++G  F      L  RLR   FR+++ Q+ ++F
Sbjct: 788  KEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWF 847

Query: 278  DE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMG 335
            D+  N  G L +RL +D + V       I + + +   VT  ++  FS SW+LSLV    
Sbjct: 848  DDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCF 907

Query: 336  FPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKL 395
            FP + +      +     +   + AL        E +S ++TV     E    E    +L
Sbjct: 908  FPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETEL 967

Query: 396  QQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVL 455
            ++ +K   ++A  Y +    +   + +   +   YGG+L+ +  +    +   I    + 
Sbjct: 968  EKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLS 1027

Query: 456  GDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP--TMVHDGSLAPDHLEGRVDFENVTFTY 513
               +    S      +   +A + F+ +DRQP  ++ +      D+ +G++DF +  FTY
Sbjct: 1028 ATALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTY 1087

Query: 514  RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAY 573
             +RP +QVL  +S S+SPG+  A VG SG GKS+ + +LE FY  + G+V++DG      
Sbjct: 1088 PSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKV 1147

Query: 574  DHKYLHRVISLVSQEPVLFARSITDNISYGLPT--VPFEMVVEAAQKANAHGFIMELQDG 631
            + ++L   I +VSQEPVLFA SI DNI YG  T  +P E V+ AA++A  H F+M L + 
Sbjct: 1148 NVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEK 1207

Query: 632  YSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQK 691
            Y T  G +G+QLS G+KQR+A+ARA+VR+P +L+LDEATSALD ESE  +Q A+    + 
Sbjct: 1208 YETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREG 1267

Query: 692  HTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLV 738
             T ++IAHRLST+++A +I V+ +G V+++GTH++L+AQ G Y KLV
Sbjct: 1268 RTCIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLV 1314



 Score =  308 bits (788), Expect = 2e-83
 Identities = 180/546 (32%), Positives = 291/546 (53%), Gaps = 27/546 (4%)

Query: 204 FLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRN 263
           F  YY G A+  ++         T  + +C   I +               AR   ++R 
Sbjct: 141 FASYYAGIAVAVLI---------TGYIQICFWVIAA---------------ARQIQKMRK 176

Query: 264 CLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS 323
             FR ++  E  +FD N  G+L +R + D   ++D ++  + +F++         +  F 
Sbjct: 177 FYFRRIMRMEIGWFDCNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFF 236

Query: 324 LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
             W+L+LV     P+I + +   G    + +     A A+A   A+E IS+M+TV +F  
Sbjct: 237 RGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGG 296

Query: 384 EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVIS-GQMTS 442
           E+ E E Y + L    +   ++     ++       + +      +YG  LV+  G+ T 
Sbjct: 297 EKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTP 356

Query: 443 GNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHL 500
           G L+   +   V    + +          G  AA  +FE IDR+P +  + +     D +
Sbjct: 357 GTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRI 416

Query: 501 EGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEG 560
           +G ++F NVTF Y +RP  ++L +++  + PG++TALVGPSG+GKS+ + +++ FY    
Sbjct: 417 KGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCE 476

Query: 561 GRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKAN 620
           G V +DG  I + + ++L   I +V QEPVLF+ +I +NI YG      E +V+AA++AN
Sbjct: 477 GMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEAN 536

Query: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
           A+ FIM+L   + T  GE G Q+SGGQKQRVA+ARAL+RNP +L+LD ATSALD ESE +
Sbjct: 537 AYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAM 596

Query: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
           +Q+ +      HT++ +AHRLSTV  A  I+  + G  V++GTH++LL + G+Y  LV  
Sbjct: 597 VQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTL 656

Query: 741 QMLGLQ 746
           Q  G Q
Sbjct: 657 QSQGNQ 662


>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
           sapiens]
          Length = 1280

 Score =  317 bits (813), Expect = 2e-86
 Identities = 180/526 (34%), Positives = 302/526 (57%), Gaps = 14/526 (2%)

Query: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
           +  G   AA I+   + L   R   ++R   F +++ QE  +FD +  G+L +RLT D +
Sbjct: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180

Query: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
            +++ +   I +F ++        +  F+  W+L+LV     P++ + + ++ K     +
Sbjct: 181 KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT 240

Query: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
            +   A A+A   AEE ++A++TV +F  +++E E Y + L++  ++  K+A      + 
Sbjct: 241 DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG 300

Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLI----AFIIYEFVLGDCMESVGSVYSGLM 470
            + L +        +YG  LV+SG+ + G ++    + +I  F +G    S+        
Sbjct: 301 AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSI----EAFA 356

Query: 471 QGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFS 528
              GAA ++F+ ID +P++         PD+++G ++F NV F+Y +R   ++L+ ++  
Sbjct: 357 NARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLK 416

Query: 529 LSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQE 588
           +  G+  ALVG SG GKS+ V +++  Y    G V +DG+ I   + ++L  +I +VSQE
Sbjct: 417 VQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQE 476

Query: 589 PVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQK 648
           PVLFA +I +NI YG   V  + + +A ++ANA+ FIM+L   + T  GE+GAQLSGGQK
Sbjct: 477 PVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQK 536

Query: 649 QRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAH 708
           QR+A+ARALVRNP +L+LDEATSALD ESE ++Q A+    +  T ++IAHRLSTV +A 
Sbjct: 537 QRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNAD 596

Query: 709 LIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLG----LQPAAD 750
           +I   D G +V++G H +L+ + G+Y KLV  Q  G    L+ AAD
Sbjct: 597 VIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAAD 642



 Score =  306 bits (783), Expect = 6e-83
 Identities = 192/499 (38%), Positives = 278/499 (55%), Gaps = 22/499 (4%)

Query: 257  LNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKV 314
            L  RLR  +FRS++ Q+ S+FD+  N TG L +RL +D   V   +   + V  +N   +
Sbjct: 784  LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANL 843

Query: 315  TGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISA 374
               ++  F   WQL+L+     PII +   +  K     + + +  L  +   A E I  
Sbjct: 844  GTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIEN 903

Query: 375  MKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-YGGH 433
             +TV S   E++   +Y + LQ  Y+ + ++A  +       G+T    Q  + + Y G 
Sbjct: 904  FRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-------GITFSFTQAMMYFSYAGC 956

Query: 434  LVISGQMTSGNLIAF----IIYEFVLGDCMESVGSVYSGLMQGVGA---AEKVFEFIDRQ 486
                  + +  L++F    +++  V+   M +VG V S       A   A  +   I++ 
Sbjct: 957  FRFGAYLVAHKLMSFEDVLLVFSAVVFGAM-AVGQVSSFAPDYAKAKISAAHIIMIIEKT 1015

Query: 487  PTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSG 544
            P +       L P+ LEG V F  V F Y TRP   VLQ +S  +  G+  ALVG SG G
Sbjct: 1016 PLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCG 1075

Query: 545  KSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG- 603
            KS+ V +LE FY    G+VLLDGK I   + ++L   + +VSQEP+LF  SI +NI+YG 
Sbjct: 1076 KSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGD 1135

Query: 604  -LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPP 662
                V  E +V AA++AN H FI  L + YST+ G+KG QLSGGQKQR+A+ARALVR P 
Sbjct: 1136 NSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPH 1195

Query: 663  VLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQG 722
            +L+LDEATSALD ESE ++Q+A+    +  T ++IAHRLST+++A LIVV   GRV + G
Sbjct: 1196 ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHG 1255

Query: 723  THQQLLAQGGLYAKLVQRQ 741
            THQQLLAQ G+Y  +V  Q
Sbjct: 1256 THQQLLAQKGIYFSMVSVQ 1274


>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
           [Homo sapiens]
          Length = 1286

 Score =  314 bits (805), Expect = 2e-85
 Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)

Query: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
           L  G   AA I+   +TL   R   ++R   F +++ QE  +FD N T +L +RLT D +
Sbjct: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182

Query: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
            +S+ +   + +F +         +  F   W+L+LV     PI+ + + ++ K     S
Sbjct: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242

Query: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
            +   A A+A   AEE + A++TV +F  + +E E Y + L+   ++  K+A +    + 
Sbjct: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302

Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
            + L +        +YG  LVIS + T GN +       +    +              G
Sbjct: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362

Query: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
           AA  +F+ ID  P +    +    PD ++G ++F +V F+Y +R + ++L+ ++  +  G
Sbjct: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422

Query: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
           +  ALVG SG GKS+ V +++  Y  + G + +DG+ I  ++  YL  +I +VSQEPVLF
Sbjct: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482

Query: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
           + +I +NI YG   V  + + +A ++ANA+ FIM+L   + T  GE+GAQLSGGQKQR+A
Sbjct: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542

Query: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
           +ARALVRNP +L+LDEATSALD ESE  +Q A+    +  T ++IAHRLSTV +A +I  
Sbjct: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602

Query: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
            + G +V+QG+H +L+ + G+Y KLV  Q  G Q
Sbjct: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636



 Score =  299 bits (765), Expect = 7e-81
 Identities = 198/549 (36%), Positives = 291/549 (53%), Gaps = 32/549 (5%)

Query: 214  DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
            D  V Q+  + FS   +I   L I S F   ++G  F      L  RLR+  F++++ Q+
Sbjct: 743  DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799

Query: 274  TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
             S+FD+  N TG L +RL +D   V       + +  +N   +   ++  F   WQL+L+
Sbjct: 800  MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859

Query: 332  TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
                 PII +   +  K     +K  +  L  A   A E I  ++TV S   E +   +Y
Sbjct: 860  LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919

Query: 392  LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-------YGGHLVISGQMTSGN 444
            + KL   Y+ + ++A  Y       G+T  + Q  + +       +G +L+++G M   +
Sbjct: 920  VEKLYGPYRNSVQKAHIY-------GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD 972

Query: 445  LIAFIIYEFVLGD-CMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLE 501
            +I  +    V G   +    S      +   +A  +F   +RQP +    +  L PD  E
Sbjct: 973  VI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE 1031

Query: 502  GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFY-PLEG 560
            G + F  V F Y TR +  VLQ +S  +  G+  ALVG SG GKS+ V +LE FY PL G
Sbjct: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091

Query: 561  ------GRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMV 612
                  G  LLDG+     + ++L   + +VSQEP+LF  SI +NI+YG     V  + +
Sbjct: 1092 TVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEI 1151

Query: 613  VEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSA 672
            V AA+ AN H FI  L   Y T  G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSA
Sbjct: 1152 VSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSA 1211

Query: 673  LDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGG 732
            LD ESE ++Q+A+    +  T ++IAHRLST+++A LIVV   GRV + GTHQQLLAQ G
Sbjct: 1212 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKG 1271

Query: 733  LYAKLVQRQ 741
            +Y  +V  Q
Sbjct: 1272 IYFSMVSVQ 1280


>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
           [Homo sapiens]
          Length = 1232

 Score =  314 bits (805), Expect = 2e-85
 Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)

Query: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
           L  G   AA I+   +TL   R   ++R   F +++ QE  +FD N T +L +RLT D +
Sbjct: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182

Query: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
            +S+ +   + +F +         +  F   W+L+LV     PI+ + + ++ K     S
Sbjct: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242

Query: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
            +   A A+A   AEE + A++TV +F  + +E E Y + L+   ++  K+A +    + 
Sbjct: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302

Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
            + L +        +YG  LVIS + T GN +       +    +              G
Sbjct: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362

Query: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
           AA  +F+ ID  P +    +    PD ++G ++F +V F+Y +R + ++L+ ++  +  G
Sbjct: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422

Query: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
           +  ALVG SG GKS+ V +++  Y  + G + +DG+ I  ++  YL  +I +VSQEPVLF
Sbjct: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482

Query: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
           + +I +NI YG   V  + + +A ++ANA+ FIM+L   + T  GE+GAQLSGGQKQR+A
Sbjct: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542

Query: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
           +ARALVRNP +L+LDEATSALD ESE  +Q A+    +  T ++IAHRLSTV +A +I  
Sbjct: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602

Query: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
            + G +V+QG+H +L+ + G+Y KLV  Q  G Q
Sbjct: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636



 Score =  282 bits (721), Expect = 9e-76
 Identities = 189/534 (35%), Positives = 267/534 (50%), Gaps = 56/534 (10%)

Query: 214  DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
            D  V Q+  + FS   +I   L I S F   ++G  F      L  RLR+  F++++ Q+
Sbjct: 743  DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799

Query: 274  TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
             S+FD+  N TG L +RL +D   V       + +  +N   +   ++  F   WQL+L+
Sbjct: 800  MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859

Query: 332  TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
                 PII +   +  K     +K  +  L  A   A E I  ++TV S   E +   +Y
Sbjct: 860  LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919

Query: 392  LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIY 451
            + KL                                  YG + V S         A +  
Sbjct: 920  VEKL----------------------------------YGPYRVFS---------AIVFG 936

Query: 452  EFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENV 509
               LG             +    +A  +F   +RQP +    +  L PD  EG + F  V
Sbjct: 937  AVALGHASSFAPDYAKAKL----SAAHLFMLFERQPLIDSYSEEGLKPDKFEGNITFNEV 992

Query: 510  TFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKP 569
             F Y TR +  VLQ +S  +  G+  ALVG SG GKS+ V +LE FY    G VLLDG+ 
Sbjct: 993  VFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGTVLLDGQE 1052

Query: 570  ISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIME 627
                + ++L   + +VSQEP+LF  SI +NI+YG     V  + +V AA+ AN H FI  
Sbjct: 1053 AKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIET 1112

Query: 628  LQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHG 687
            L   Y T  G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE ++Q+A+  
Sbjct: 1113 LPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEKVVQEALDK 1172

Query: 688  NLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
              +  T ++IAHRLST+++A LIVV   GRV + GTHQQLLAQ G+Y  +V  Q
Sbjct: 1173 AREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1226


>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
           [Homo sapiens]
          Length = 1279

 Score =  314 bits (805), Expect = 2e-85
 Identities = 178/514 (34%), Positives = 287/514 (55%), Gaps = 2/514 (0%)

Query: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
           L  G   AA I+   +TL   R   ++R   F +++ QE  +FD N T +L +RLT D +
Sbjct: 123 LGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDIS 182

Query: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
            +S+ +   + +F +         +  F   W+L+LV     PI+ + + ++ K     S
Sbjct: 183 KISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFS 242

Query: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
            +   A A+A   AEE + A++TV +F  + +E E Y + L+   ++  K+A +    + 
Sbjct: 243 DKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIKKAISANISMG 302

Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVG 474
            + L +        +YG  LVIS + T GN +       +    +              G
Sbjct: 303 IAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARG 362

Query: 475 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
           AA  +F+ ID  P +    +    PD ++G ++F +V F+Y +R + ++L+ ++  +  G
Sbjct: 363 AAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKILKGLNLKVQSG 422

Query: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
           +  ALVG SG GKS+ V +++  Y  + G + +DG+ I  ++  YL  +I +VSQEPVLF
Sbjct: 423 QTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREIIGVVSQEPVLF 482

Query: 593 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 652
           + +I +NI YG   V  + + +A ++ANA+ FIM+L   + T  GE+GAQLSGGQKQR+A
Sbjct: 483 STTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQLSGGQKQRIA 542

Query: 653 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 712
           +ARALVRNP +L+LDEATSALD ESE  +Q A+    +  T ++IAHRLSTV +A +I  
Sbjct: 543 IARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLSTVRNADVIAG 602

Query: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQ 746
            + G +V+QG+H +L+ + G+Y KLV  Q  G Q
Sbjct: 603 FEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQ 636



 Score =  304 bits (779), Expect = 2e-82
 Identities = 196/542 (36%), Positives = 289/542 (53%), Gaps = 25/542 (4%)

Query: 214  DGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQE 273
            D  V Q+  + FS   +I   L I S F   ++G  F      L  RLR+  F++++ Q+
Sbjct: 743  DDAVKQQKCNIFS---LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQD 799

Query: 274  TSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLV 331
             S+FD+  N TG L +RL +D   V       + +  +N   +   ++  F   WQL+L+
Sbjct: 800  MSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLL 859

Query: 332  TFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVY 391
                 PII +   +  K     +K  +  L  A   A E I  ++TV S   E +   +Y
Sbjct: 860  LLAVVPIIAVSGIVEMKLLAGNAKRDKKELEAAGKIATEAIENIRTVVSLTQERKFESMY 919

Query: 392  LRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-------YGGHLVISGQMTSGN 444
            + KL   Y+ + ++A  Y       G+T  + Q  + +       +G +L+++G M   +
Sbjct: 920  VEKLYGPYRNSVQKAHIY-------GITFSISQAFMYFSYAGCFRFGAYLIVNGHMRFRD 972

Query: 445  LIAFIIYEFVLGD-CMESVGSVYSGLMQGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLE 501
            +I  +    V G   +    S      +   +A  +F   +RQP +    +  L PD  E
Sbjct: 973  VI-LVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFERQPLIDSYSEEGLKPDKFE 1031

Query: 502  GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGG 561
            G + F  V F Y TR +  VLQ +S  +  G+  ALVG SG GKS+ V +LE FY    G
Sbjct: 1032 GNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1091

Query: 562  RVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKA 619
             VLLDG+     + ++L   + +VSQEP+LF  SI +NI+YG     V  + +V AA+ A
Sbjct: 1092 TVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYGDNSRVVSQDEIVSAAKAA 1151

Query: 620  NAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEY 679
            N H FI  L   Y T  G+KG QLSGGQKQR+A+ARAL+R P +L+LDEATSALD ESE 
Sbjct: 1152 NIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILLLDEATSALDTESEK 1211

Query: 680  LIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
            ++Q+A+    +  T ++IAHRLST+++A LIVV   GRV + GTHQQLLAQ G+Y  +V 
Sbjct: 1212 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1271

Query: 740  RQ 741
             Q
Sbjct: 1272 VQ 1273


>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
           sapiens]
          Length = 812

 Score =  280 bits (715), Expect = 5e-75
 Identities = 191/601 (31%), Positives = 309/601 (51%), Gaps = 55/601 (9%)

Query: 173 TLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYT---GRAI------DGIVIQKSMD 223
           +L K+L   KP+  F+V  +   + + L  T  P ++    + I      D   ++   +
Sbjct: 232 SLLKILKLNKPEWPFVVLGT---LASVLNGTVHPVFSIIFAKIITMFGNNDKTTLKHDAE 288

Query: 224 QFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDE--NR 281
            +S   VI+ ++   S F  G+  G    I   L +RLR+  F++++ Q+ ++FDE  N 
Sbjct: 289 IYSMIFVILGVICFVSYFMQGLFYGRAGEI---LTMRLRHLAFKAMLYQDIAWFDEKENS 345

Query: 282 TGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMM 341
           TG L + L  D   +       I V  +N   +   V+  F   W+++ +     P++ +
Sbjct: 346 TGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAV 405

Query: 342 VSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKL 401
              I        + + +  L  A   A E +  ++T+ S   E+   ++Y   LQ  ++ 
Sbjct: 406 TGMIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRN 465

Query: 402 NRKEAA----------AYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIY 451
             K+A           A++Y+ + +G            +G +L+ +G+MT   +  FI++
Sbjct: 466 TSKKAQIIGSCYAFSHAFIYFAYAAGFR----------FGAYLIQAGRMTPEGM--FIVF 513

Query: 452 EFVLGDCMESVGSV------YSGLMQGVGAAEKVFEFIDRQPTM---VHDGSLAPDHLEG 502
             +    M ++G        YS    G   A  +F  ++++P +     +G   PD  EG
Sbjct: 514 TAIAYGAM-AIGETLVLAPEYSKAKSG---AAHLFALLEKKPNIDSRSQEGK-KPDTCEG 568

Query: 503 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 562
            ++F  V+F Y  RP   +L+ +S S+  GK  A VG SG GKS+ V +L+  Y    G+
Sbjct: 569 NLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQ 628

Query: 563 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFEMVVEAAQKAN 620
           VL DG      + ++L   I++V QEPVLF  SI +NI+YG     VP + + EAA  AN
Sbjct: 629 VLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAAN 688

Query: 621 AHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYL 680
            H FI  L + Y+T+ G KGAQLSGGQKQR+A+ARAL++ P +L+LDEATSALD +SE +
Sbjct: 689 IHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKV 748

Query: 681 IQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
           +Q A+       T L++ HRLS +++A LIVVL  G++ +QGTHQ+LL    +Y KLV  
Sbjct: 749 VQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNA 808

Query: 741 Q 741
           Q
Sbjct: 809 Q 809



 Score =  171 bits (432), Expect = 3e-42
 Identities = 89/178 (50%), Positives = 124/178 (69%)

Query: 564 LLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHG 623
           ++D   I A + ++    I +VSQEPVLF  +I++NI YG   V  E +  AA++ANA+ 
Sbjct: 1   MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYD 60

Query: 624 FIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQ 683
           FIME  + ++T  GEKGAQ+SGGQKQR+A+ARALVRNP +LILDEATSALD+ES+  +Q 
Sbjct: 61  FIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQA 120

Query: 684 AIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
           A+    +  T +++AHRLST+  A LIV L  G + ++G H +L+A+ GLY  LV  Q
Sbjct: 121 ALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178


>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
           sapiens]
          Length = 842

 Score =  234 bits (596), Expect = 3e-61
 Identities = 186/659 (28%), Positives = 317/659 (48%), Gaps = 38/659 (5%)

Query: 115 WFWA-----------LFVWTYISLGASFLLWWLLSTVRPGTQAL---EPGAATEAEGFPG 160
           W+WA           L+V  Y+  G  F+L      +RP +  L   E     E      
Sbjct: 173 WWWARADLGQQVQFSLWVLRYVVSGGLFVLGLWAPGLRPQSYTLQVHEEDQDVERSQVRS 232

Query: 161 SGRPPPEQASGATLQKLLSYTKP------DVAFLVAASFFLIVAALGETFLPYYTGRAID 214
           + +    +  G  L+ L  Y  P       +  L+      +  AL      +Y  R I 
Sbjct: 233 AAQQSTWRDFGRKLRLLSGYLWPRGSPALQLVVLICLGLMGLERALNVLVPIFY--RNIV 290

Query: 215 GIVIQK----SMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARL----NIRLRNCLF 266
            ++ +K    S+    T+ V +  L  G + + G    + T ++ R+    + R+   +F
Sbjct: 291 NLLTEKAPWNSLAWTVTSYVFLKFLQGGGTGSTGFVSNLRTFLWIRVQQFTSRRVELLIF 350

Query: 267 RSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNI-NVFLRNTVKVTGVVVF-MFSL 324
             L      +    RTG+++      T+ V+ L+S  + NV       + G++ F MF  
Sbjct: 351 SHLHELSLRWHLGRRTGEVLRIADRGTSSVTGLLSYLVFNVIPTLADIIIGIIYFSMFFN 410

Query: 325 SWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANE 384
           +W   L+ F+   + + ++ +  ++  +  + +          A +++   +TV+ +  E
Sbjct: 411 AW-FGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARAVDSLLNFETVKYYNAE 469

Query: 385 EEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGN 444
             E E Y   + +   L  K +A+ +       L + +  ++      + V   ++  G+
Sbjct: 470 SYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLGLLAGSLLCAYFVTEQKLQVGD 529

Query: 445 LIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHD--GSLAPDHLEG 502
            + F  Y   L   +   G+ Y  +       E +F+ + ++ T V D  G+      +G
Sbjct: 530 YVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMENMFDLL-KEETEVKDLPGAGPLRFQKG 588

Query: 503 RVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGR 562
           R++FENV F+Y     T  LQ+VSF++ PG+  ALVGPSG+GKS+ + +L  FY +  G 
Sbjct: 589 RIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVGPSGAGKSTILRLLFRFYDISSGC 646

Query: 563 VLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAH 622
           + +DG+ IS      L   I +V Q+ VLF  +I DNI YG  T   + V  AAQ A  H
Sbjct: 647 IRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADNIRYGRVTAGNDEVEAAAQAAGIH 706

Query: 623 GFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQ 682
             IM   +GY T+ GE+G +LSGG+KQRVA+AR +++ P +++LDEATSALD  +E  IQ
Sbjct: 707 DAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILKAPGIILLDEATSALDTSNERAIQ 766

Query: 683 QAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQ 741
            ++       T +++AHRLSTV +A  I+V+  G +V++G H+ LL++GG+YA + Q Q
Sbjct: 767 ASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIVERGRHEALLSRGGVYADMWQLQ 825


>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
           sapiens]
          Length = 753

 Score =  214 bits (545), Expect = 2e-55
 Identities = 177/602 (29%), Positives = 292/602 (48%), Gaps = 38/602 (6%)

Query: 174 LQKLLSYT----KPDVAFLVAASF-FLIVAALGETFLPYYTGRAIDGI-VIQKSMDQFST 227
           ++ +LSY     +PD+   VA S  FL  A      +P+    A+D +  +  +M   S 
Sbjct: 122 IKAMLSYVWPKDRPDLRARVAISLGFLGGAKAMNIVVPFMFKYAVDSLNQMSGNMLNLSD 181

Query: 228 AVVIVCLLAI-----------GSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSF 276
           A   V  +A            G++F   +R  +F  +      R+   +F  L + +  F
Sbjct: 182 APNTVATMATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNSIRRIAKNVFLHLHNLDLGF 241

Query: 277 FDENRTGDLISRLTSDTTMVSDLVSQ---NINVFLRNTVKVTGVVVF----MFSLSWQLS 329
               +TG L   +   T  +S ++S    N+   +   + V+GV+ +     F+L    +
Sbjct: 242 HLSRQTGALSKAIDRGTRGISFVLSALVFNLLPIMFEVMLVSGVLYYKCGAQFALVTLGT 301

Query: 330 LVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAE 389
           L T+  F + +       ++  R   E+  A   A N A +++   +TV+ F NE  EA+
Sbjct: 302 LGTYTAFTVAVT------RWRTRFRIEMNKADNDAGNAAIDSLLNYETVKYFNNERYEAQ 355

Query: 390 VYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFI 449
            Y   L+     + K  +      +G      V   +I+      +++G +T G+L+   
Sbjct: 356 RYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQGIVAGTLTVGDLVMVN 415

Query: 450 IYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPD----HLEGRVD 505
              F L   +  +G+VY    Q +     +F  + +  T + D  +A           V 
Sbjct: 416 GLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLL-KVDTQIKDKVMASPLQITPQTATVA 474

Query: 506 FENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLL 565
           F+NV F Y      +VL  +SF +  GK  A+VG SGSGKS+ V +L  FY  + G + L
Sbjct: 475 FDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYL 532

Query: 566 DGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFI 625
            G+ I     + L R + +V Q+ VLF  +I  N+ YG  +   E V   A+ A  H  I
Sbjct: 533 AGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYNLLYGNISASPEEVYAVAKLAGLHDAI 592

Query: 626 MELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAI 685
           + +  GY T+ GE+G +LSGG+KQRVA+ARA++++PPV++ DEATS+LD+ +E  I  A+
Sbjct: 593 LRMPHGYDTQVGERGLKLSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAM 652

Query: 686 HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQMLG 744
              ++  T + IAHRLSTV  A  I+VLD+G+V ++GTH  LLA    +Y+++   Q   
Sbjct: 653 KDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQSSR 712

Query: 745 LQ 746
           +Q
Sbjct: 713 VQ 714


>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
            [Homo sapiens]
          Length = 1545

 Score =  168 bits (426), Expect = 2e-41
 Identities = 127/512 (24%), Positives = 247/512 (48%), Gaps = 29/512 (5%)

Query: 235  LAIGSSFAAGIRGGIFTLI--------FARLNIRLRNCLFRSLVSQETSFFDENRTGDLI 286
            + +G   A G+  GIF  I        F   +  L   L  +++     FFD   TG ++
Sbjct: 1022 MRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHKQLLNNILRAPMRFFDTTPTGRIV 1081

Query: 287  SRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIY 346
            +R   D + V D + Q++  ++   + +   +V +   +   +++      I + V   Y
Sbjct: 1082 NRFAGDISTVDDTLPQSLRSWITCFLGIISTLVMICMATPVFTIIVIPLGIIYVSVQMFY 1141

Query: 347  GKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
                ++L +      +   +   ET+S +  +R+F +++     +L+  +     N+K  
Sbjct: 1142 VSTSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQR----FLKHNEVRIDTNQKCV 1197

Query: 407  AAYMYYVWGSGLTL-LVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDCMESVGS 464
             +++       + L LV  +++ +    +VI     SG+ + F++   + +   +  +  
Sbjct: 1198 FSWITSNRWLAIRLELVGNLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVR 1257

Query: 465  VYSGLMQGVGAAEKVFEF--IDRQPTMVHDGSLAPDH-LEGRVDFENVTFTYRTRPHTQV 521
            + S +   + A E++ E+  ++ +   V D    PD   +G++ F N    YR      V
Sbjct: 1258 MTSEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL-V 1316

Query: 522  LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 581
            L+ ++  +   +   +VG +G+GKSS  N L       GG++++DG  I++     L   
Sbjct: 1317 LRGITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREK 1376

Query: 582  ISLVSQEPVLFARSITDNISYGLPTVPF-----EMVVEAAQKANAHGFIMELQDGYSTET 636
            ++++ Q+P+LF+ S+  N+       PF     E + +A + A+   F+  LQ G S E 
Sbjct: 1377 LTIIPQDPILFSGSLRMNLD------PFNNYSDEEIWKALELAHLKSFVASLQLGLSHEV 1430

Query: 637  GEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLI 696
             E G  LS GQ+Q + + RAL+R   +L+LDEAT+A+D E++ LIQ  I       TV+ 
Sbjct: 1431 TEAGGNLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVIT 1490

Query: 697  IAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLL 728
            IAHRL T+  +  ++VLD G++++ G+ ++LL
Sbjct: 1491 IAHRLHTIMDSDKVMVLDNGKIIECGSPEELL 1522



 Score =  103 bits (258), Expect = 5e-22
 Identities = 114/511 (22%), Positives = 229/511 (44%), Gaps = 59/511 (11%)

Query: 250 FTLIFARLNIRLRNCLFRSLVSQETSFFD----ENRTGDLISRLTSDTTMVSDLVSQNIN 305
           F L F +L +++R  +  S+  +  +  +    E   G+ ++ ++ D   + D+     N
Sbjct: 382 FQLCF-KLGVKVRTAIMASVYKKALTLSNLARKEYTVGETVNLMSVDAQKLMDVT----N 436

Query: 306 VFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMV---SNIYGKYYKRLSKEVQNALA 362
                   V  +V+ +F L  +L      G  ++++V   + I     K +  +      
Sbjct: 437 FMHMLWSSVLQIVLSIFFLWRELGPSVLAGVGVMVLVIPINAILSTKSKTIQVKNMKNKD 496

Query: 363 RASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLV 422
           +      E +S +K ++ FA E    +       QV  L +KE    + +     + + V
Sbjct: 497 KRLKIMNEILSGIKILKYFAWEPSFRD-------QVQNLRKKELKNLLAFSQLQCVVIFV 549

Query: 423 VQ-----VSILYYGGHL------VISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQ 471
            Q     VS++ +  ++      ++  Q    ++  F I  F L      +  + S ++Q
Sbjct: 550 FQLTPVLVSVVTFSVYVLVDSNNILDAQKAFTSITLFNILRFPLS----MLPMMISSMLQ 605

Query: 472 GVGAAEKVFEFIDRQPTMVHDGSLAPD-HLEGRVDFENVTFTYRTRPHTQVLQNVSFSLS 530
              + E++ +++      +   ++  D + +  + F   +FT+       V ++V+  + 
Sbjct: 606 ASVSTERLEKYLGGDD--LDTSAIRHDCNFDKAMQFSEASFTWEHDSEATV-RDVNLDIM 662

Query: 531 PGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPV 590
            G++ A++GP GSGKSS ++ +              G+  + + H  +    + V Q+  
Sbjct: 663 AGQLVAVIGPVGSGKSSLISAML-------------GEMENVHGHITIKGTTAYVPQQSW 709

Query: 591 LFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQK 648
           +   +I DNI +G       ++ V+EA         +  L  G   E GEKG  LSGGQK
Sbjct: 710 IQNGTIKDNILFGTEFNEKRYQQVLEACALLPD---LEMLPGGDLAEIGEKGINLSGGQK 766

Query: 649 QRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVE 705
           QR+++ARA  +N  + +LD+  SA+DA   +++  + +  +G L+  T L++ H +  + 
Sbjct: 767 QRISLARATYQNLDIYLLDDPLSAVDAHVGKHIFNKVLGPNGLLKGKTRLLVTHSMHFLP 826

Query: 706 HAHLIVVLDKGRVVQQGTHQQLLAQGGLYAK 736
               IVVL  G +V++G++  LLA+ G +AK
Sbjct: 827 QVDEIVVLGNGTIVEKGSYSALLAKKGEFAK 857


>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
            [Homo sapiens]
          Length = 1437

 Score =  163 bits (412), Expect = 6e-40
 Identities = 140/502 (27%), Positives = 238/502 (47%), Gaps = 33/502 (6%)

Query: 245  IRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNI 304
            IRG +F     R + RL + LFR ++     FFD   TG +++R + D   V   +    
Sbjct: 931  IRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQA 990

Query: 305  NVFLRNTVKV---TGVVVFMFSLSWQLSLV--TFMGFPIIMMVSNIYGKYYKRLSKEVQN 359
             +F++N + V    G++  +F   W L  V    + F ++ +VS +  +  KRL    Q+
Sbjct: 991  EMFIQNVILVFFCVGMIAGVFP--WFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQS 1048

Query: 360  ALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLT 419
                  +    +I  + T+ ++   +E    +L + Q++   N+     +   +    + 
Sbjct: 1049 PFL---SHITSSIQGLATIHAYNKGQE----FLHRYQELLDDNQAPFFLFTCAMRWLAVR 1101

Query: 420  LLVVQVSILYYGGHLVI--SGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAE 477
            L ++ ++++   G +++   GQ+        I Y   L    +    + S       + E
Sbjct: 1102 LDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVE 1161

Query: 478  KVFEFID----RQPTMVHDGSLAPDH-LEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
            ++  +I       P  + + + +PD   EG V FEN    YR      VL+ VSF++ P 
Sbjct: 1162 RINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENAEMRYRENLPL-VLKKVSFTIKPK 1220

Query: 533  KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
            +   +VG +GSGKSS    L     L GG + +DG  IS      L   +S++ QEPVLF
Sbjct: 1221 EKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLF 1280

Query: 593  ARSITDNISYGLPTVPFEMVVE-----AAQKANAHGFIMELQDGYSTETGEKGAQLSGGQ 647
            + ++  N+       PF    E     A ++ +    I +L     +E  E G   S G+
Sbjct: 1281 SGTVRSNLD------PFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGE 1334

Query: 648  KQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHA 707
            +Q + +ARAL+R+  +LILDEAT+A+D E++ LIQ+ I       T+L IAHRL TV  +
Sbjct: 1335 RQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGS 1394

Query: 708  HLIVVLDKGRVVQQGTHQQLLA 729
              I+VL +G+VV+  T   LL+
Sbjct: 1395 DRIMVLAQGQVVEFDTPSVLLS 1416



 Score =  103 bits (257), Expect = 6e-22
 Identities = 67/247 (27%), Positives = 119/247 (48%), Gaps = 18/247 (7%)

Query: 520 QVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLH 579
           + L ++   +  GK+  + G  GSGK+S ++ +     L  G + + G            
Sbjct: 576 RTLHSIDLEIQEGKLVGICGSVGSGKTSLISAILGQMTLLEGSIAISG------------ 623

Query: 580 RVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEK 639
              + V+Q+  +   ++ DNI +G      E              +  L     TE GE+
Sbjct: 624 -TFAYVAQQAWILNATLRDNILFG-KEYDEERYNSVLNSCCLRPDLAILPSSDLTEIGER 681

Query: 640 GAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIA 698
           GA LSGGQ+QR+++ARAL  +  + ILD+  SALDA    ++   AI  +L+  TVL + 
Sbjct: 682 GANLSGGQRQRISLARALYSDRSIYILDDPLSALDAHVGNHIFNSAIRKHLKSKTVLFVT 741

Query: 699 HRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEP 758
           H+L  +     ++ + +G + ++GTH++L+   G YA +    +LG  P  +    +++ 
Sbjct: 742 HQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGDYATIFNNLLLGETPPVEI---NSKK 798

Query: 759 VANGSHK 765
             +GS K
Sbjct: 799 ETSGSQK 805


>gi|134142345 ATP-binding cassette, sub-family C, member 1 isoform 3
            [Homo sapiens]
          Length = 1475

 Score =  162 bits (409), Expect = 1e-39
 Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)

Query: 265  LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
            L  S++    SFF+   +G+L++R + +   V  ++ + I +F+ +   V G  +V + +
Sbjct: 996  LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1055

Query: 324  LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
                  ++  +G  I   V   Y    ++L +    + +   +   ET+  +  +R+F  
Sbjct: 1056 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1112

Query: 384  EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
            EE+E  ++    Q   K++  + A Y   V    L + +  V    +L+     VIS   
Sbjct: 1113 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1168

Query: 441  TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
             S  L+   + Y   +   +  +  + S +   + A E++ E+ + +   P  + + +  
Sbjct: 1169 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1228

Query: 497  PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
                + GRV+F N    YR      VL++++ +++ G+   +VG +G+GKSS    L   
Sbjct: 1229 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1287

Query: 556  YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
                 G +++DG  I+      L   I+++ Q+PVLF+ S+  N+       PF     E
Sbjct: 1288 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1341

Query: 611  MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
             V  + + A+   F+  L D    E  E G  LS GQ+Q V +ARAL+R   +L+LDEAT
Sbjct: 1342 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1401

Query: 671  SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
            +A+D E++ LIQ  I    +  TVL IAHRL+T+     ++VLDKG + + G    LL Q
Sbjct: 1402 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1461

Query: 731  GGLYAKLVQ 739
             GL+  + +
Sbjct: 1462 RGLFYSMAK 1470



 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 93/502 (18%), Positives = 198/502 (39%), Gaps = 102/502 (20%)

Query: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
           R+   +   ++R  +    S    +  G++++ ++ D     DL +  IN+     ++V 
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452

Query: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
            + +++  L+   S++  +   ++M+  N    +  K Y+    + ++   +  N   E 
Sbjct: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508

Query: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
           ++ +K ++ +A E    +  L   Q+  K+ +K A  +A   + W     L+ +    +Y
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568

Query: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
                + ++  Q    +L  F I  F L      +  V S ++Q   + +++  F+  + 
Sbjct: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623

Query: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTAL 537
                  L PD +E R          +   N TFT+  R     L  ++FS+  G + A+
Sbjct: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAV 676

Query: 538 VGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSIT 597
           VG  G GKSS ++ L        G V + G              ++ V Q+  +   S+ 
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLR 723

Query: 598 DNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARAL 657
           +NI +                                     G QL     + V  A AL
Sbjct: 724 ENILF-------------------------------------GCQLEEPYYRSVIQACAL 746

Query: 658 VRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGR 717
           + +  +L   + T                  + + T +++ H +S +    +I+V+  G+
Sbjct: 747 LPDLEILPSGDRT-----------------EIGEKTRILVTHSMSYLPQVDVIIVMSGGK 789

Query: 718 VVQQGTHQQLLAQGGLYAKLVQ 739
           + + G++Q+LLA+ G +A+ ++
Sbjct: 790 ISEMGSYQELLARDGAFAEFLR 811


>gi|134142342 ATP-binding cassette, sub-family C, member 1 isoform 4
            [Homo sapiens]
          Length = 1416

 Score =  162 bits (409), Expect = 1e-39
 Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)

Query: 265  LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
            L  S++    SFF+   +G+L++R + +   V  ++ + I +F+ +   V G  +V + +
Sbjct: 937  LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 996

Query: 324  LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
                  ++  +G  I   V   Y    ++L +    + +   +   ET+  +  +R+F  
Sbjct: 997  TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1053

Query: 384  EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
            EE+E  ++    Q   K++  + A Y   V    L + +  V    +L+     VIS   
Sbjct: 1054 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1109

Query: 441  TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
             S  L+   + Y   +   +  +  + S +   + A E++ E+ + +   P  + + +  
Sbjct: 1110 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1169

Query: 497  PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
                + GRV+F N    YR      VL++++ +++ G+   +VG +G+GKSS    L   
Sbjct: 1170 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1228

Query: 556  YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
                 G +++DG  I+      L   I+++ Q+PVLF+ S+  N+       PF     E
Sbjct: 1229 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1282

Query: 611  MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
             V  + + A+   F+  L D    E  E G  LS GQ+Q V +ARAL+R   +L+LDEAT
Sbjct: 1283 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1342

Query: 671  SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
            +A+D E++ LIQ  I    +  TVL IAHRL+T+     ++VLDKG + + G    LL Q
Sbjct: 1343 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1402

Query: 731  GGLYAKLVQ 739
             GL+  + +
Sbjct: 1403 RGLFYSMAK 1411



 Score = 43.9 bits (102), Expect = 6e-04
 Identities = 68/344 (19%), Positives = 144/344 (41%), Gaps = 35/344 (10%)

Query: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
           R+   +   ++R  +    S    +  G++++ ++ D     DL +  IN+     ++V 
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452

Query: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
            + +++  L+   S++  +   ++M+  N    +  K Y+    + ++   +  N   E 
Sbjct: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508

Query: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
           ++ +K ++ +A E    +  L   Q+  K+ +K A  +A   + W     L+ +    +Y
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568

Query: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
                + ++  Q    +L  F I  F L      +  V S ++Q   + +++  F+  + 
Sbjct: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623

Query: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTAL 537
                  L PD +E R          +   N TFT+  R     L  ++FS+  G + A+
Sbjct: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAV 676

Query: 538 VGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRV 581
           VG  G GKSS ++ L        G V +  + +  +   YL +V
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKTRILVTHSMSYLPQV 720



 Score = 40.0 bits (92), Expect = 0.008
 Identities = 19/69 (27%), Positives = 42/69 (60%), Gaps = 5/69 (7%)

Query: 671 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
           SAL AE +      + G++   T +++ H +S +    +I+V+  G++ + G++Q+LLA+
Sbjct: 689 SALLAEMD-----KVEGHVAIKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLAR 743

Query: 731 GGLYAKLVQ 739
            G +A+ ++
Sbjct: 744 DGAFAEFLR 752


>gi|134142340 ATP-binding cassette, sub-family C, member 1 isoform 2
            [Homo sapiens]
          Length = 1472

 Score =  162 bits (409), Expect = 1e-39
 Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)

Query: 265  LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
            L  S++    SFF+   +G+L++R + +   V  ++ + I +F+ +   V G  +V + +
Sbjct: 993  LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1052

Query: 324  LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
                  ++  +G  I   V   Y    ++L +    + +   +   ET+  +  +R+F  
Sbjct: 1053 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1109

Query: 384  EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
            EE+E  ++    Q   K++  + A Y   V    L + +  V    +L+     VIS   
Sbjct: 1110 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1165

Query: 441  TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
             S  L+   + Y   +   +  +  + S +   + A E++ E+ + +   P  + + +  
Sbjct: 1166 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1225

Query: 497  PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
                + GRV+F N    YR      VL++++ +++ G+   +VG +G+GKSS    L   
Sbjct: 1226 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1284

Query: 556  YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
                 G +++DG  I+      L   I+++ Q+PVLF+ S+  N+       PF     E
Sbjct: 1285 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1338

Query: 611  MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
             V  + + A+   F+  L D    E  E G  LS GQ+Q V +ARAL+R   +L+LDEAT
Sbjct: 1339 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1398

Query: 671  SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
            +A+D E++ LIQ  I    +  TVL IAHRL+T+     ++VLDKG + + G    LL Q
Sbjct: 1399 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1458

Query: 731  GGLYAKLVQ 739
             GL+  + +
Sbjct: 1459 RGLFYSMAK 1467



 Score = 74.3 bits (181), Expect = 4e-13
 Identities = 36/104 (34%), Positives = 67/104 (64%), Gaps = 3/104 (2%)

Query: 639 KGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVL 695
           KG  LSGGQKQRV++ARA+  N  + + D+  SA+DA   +++ +  I   G L+  T +
Sbjct: 705 KGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRI 764

Query: 696 IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
           ++ H +S +    +I+V+  G++ + G++Q+LLA+ G +A+ ++
Sbjct: 765 LVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLR 808



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 67/334 (20%), Positives = 140/334 (41%), Gaps = 35/334 (10%)

Query: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
           R+   +   ++R  +    S    +  G++++ ++ D     DL +  IN+     ++V 
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452

Query: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
            + +++  L+   S++  +   ++M+  N    +  K Y+    + ++   +  N   E 
Sbjct: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508

Query: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
           ++ +K ++ +A E    +  L   Q+  K+ +K A  +A   + W     L+ +    +Y
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568

Query: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
                + ++  Q    +L  F I  F L      +  V S ++Q   + +++  F+  + 
Sbjct: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623

Query: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTAL 537
                  L PD +E R          +   N TFT+  R     L  ++FS+  G + A+
Sbjct: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAV 676

Query: 538 VGPSGSGKSSCVNILENFYPLEGGRVLLDGKPIS 571
           VG  G GKSS ++ L        G V + G  +S
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGVNLS 710


>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
            [Homo sapiens]
          Length = 1531

 Score =  162 bits (409), Expect = 1e-39
 Identities = 131/489 (26%), Positives = 235/489 (48%), Gaps = 28/489 (5%)

Query: 265  LFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGV-VVFMFS 323
            L  S++    SFF+   +G+L++R + +   V  ++ + I +F+ +   V G  +V + +
Sbjct: 1052 LLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEVIKMFMGSLFNVIGACIVILLA 1111

Query: 324  LSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFAN 383
                  ++  +G  I   V   Y    ++L +    + +   +   ET+  +  +R+F  
Sbjct: 1112 TPIAAIIIPPLGL-IYFFVQRFYVASSRQLKRLESVSRSPVYSHFNETLLGVSVIRAF-- 1168

Query: 384  EEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQM 440
            EE+E  ++    Q   K++  + A Y   V    L + +  V    +L+     VIS   
Sbjct: 1169 EEQERFIH----QSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVISRHS 1224

Query: 441  TSGNLIAFII-YEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLA 496
             S  L+   + Y   +   +  +  + S +   + A E++ E+ + +   P  + + +  
Sbjct: 1225 LSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQIQETAPP 1284

Query: 497  PDHLE-GRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENF 555
                + GRV+F N    YR      VL++++ +++ G+   +VG +G+GKSS    L   
Sbjct: 1285 SSWPQVGRVEFRNYCLRYR-EDLDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRI 1343

Query: 556  YPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPF-----E 610
                 G +++DG  I+      L   I+++ Q+PVLF+ S+  N+       PF     E
Sbjct: 1344 NESAEGEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLD------PFSQYSDE 1397

Query: 611  MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 670
             V  + + A+   F+  L D    E  E G  LS GQ+Q V +ARAL+R   +L+LDEAT
Sbjct: 1398 EVWTSLELAHLKDFVSALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEAT 1457

Query: 671  SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 730
            +A+D E++ LIQ  I    +  TVL IAHRL+T+     ++VLDKG + + G    LL Q
Sbjct: 1458 AAVDLETDDLIQSTIRTQFEDCTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ 1517

Query: 731  GGLYAKLVQ 739
             GL+  + +
Sbjct: 1518 RGLFYSMAK 1526



 Score =  112 bits (281), Expect = 1e-24
 Identities = 117/507 (23%), Positives = 231/507 (45%), Gaps = 56/507 (11%)

Query: 256 RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVT 315
           R+   +   ++R  +    S    +  G++++ ++ D     DL +  IN+     ++V 
Sbjct: 394 RIKTAVIGAVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATY-INMIWSAPLQVI 452

Query: 316 GVVVFMFSLSWQLSLVTFMGFPIIMMVSN----IYGKYYKRLSKEVQNALARASNTAEET 371
            + +++  L+   S++  +   ++M+  N    +  K Y+    + ++   +  N   E 
Sbjct: 453 -LALYLLWLNLGPSVLAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMN---EI 508

Query: 372 ISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA--AAYMYYVWGSGLTLLVVQVSILY 429
           ++ +K ++ +A E    +  L   Q+  K+ +K A  +A   + W     L+ +    +Y
Sbjct: 509 LNGIKVLKLYAWELAFKDKVLAIRQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVY 568

Query: 430 Y--GGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQP 487
                + ++  Q    +L  F I  F L      +  V S ++Q   + +++  F+  + 
Sbjct: 569 VTIDENNILDAQTAFVSLALFNILRFPLN----ILPMVISSIVQASVSLKRLRIFLSHE- 623

Query: 488 TMVHDGSLAPDHLEGR----------VDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTAL 537
                  L PD +E R          +   N TFT+  R     L  ++FS+  G + A+
Sbjct: 624 ------ELEPDSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAV 676

Query: 538 VGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSIT 597
           VG  G GKSS ++ L        G V + G              ++ V Q+  +   S+ 
Sbjct: 677 VGQVGCGKSSLLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLR 723

Query: 598 DNISYG--LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMAR 655
           +NI +G  L    +  V++A         +  L  G  TE GEKG  LSGGQKQRV++AR
Sbjct: 724 ENILFGCQLEEPYYRSVIQACALLPD---LEILPSGDRTEIGEKGVNLSGGQKQRVSLAR 780

Query: 656 ALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVEHAHLIVV 712
           A+  N  + + D+  SA+DA   +++ +  I   G L+  T +++ H +S +    +I+V
Sbjct: 781 AVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIV 840

Query: 713 LDKGRVVQQGTHQQLLAQGGLYAKLVQ 739
           +  G++ + G++Q+LLA+ G +A+ ++
Sbjct: 841 MSGGKISEMGSYQELLARDGAFAEFLR 867


>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2B [Homo sapiens]
          Length = 1549

 Score =  154 bits (388), Expect = 4e-37
 Identities = 145/588 (24%), Positives = 256/588 (43%), Gaps = 55/588 (9%)

Query: 187  FLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQF--STAVVIVCLLAIGSSFAAG 244
            +L +  FFL++  +    L +    AID  +   + +    +T          G S   G
Sbjct: 985  YLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCG 1044

Query: 245  IRGGIFTLIFARLNIR---------LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTM 295
               GIF  +   L +          L + L   ++     FFD    G +++R ++DT +
Sbjct: 1045 --AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNI 1102

Query: 296  VSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSK 355
            +   +   +    R+T+     +  M S +  + LV  +   +         KY++  SK
Sbjct: 1103 IDQHIPPTLESLTRSTLLCLSAIG-MISYATPVFLVALLPLGVAFYFIQ---KYFRVASK 1158

Query: 356  EVQNA--------LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAA 407
            ++Q          L   S TAE     + T+R+F +E        R  Q++ +L      
Sbjct: 1159 DLQELDDSTQLPLLCHFSETAE----GLTTIRAFRHET-------RFKQRMLELTDTNNI 1207

Query: 408  AYMYYVWGSGLTLLVVQVSILYYGGHLV-------ISGQMTSGNLIAFIIYEFVLGDCME 460
            AY++    +      ++V   Y G  +V       ISG   SG +   ++Y   + + + 
Sbjct: 1208 AYLFLSAANRW----LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1263

Query: 461  SVGSVYSGLMQGVGAAEKVFEFIDRQPTMVH---DGSLAPDHL--EGRVDFENVTFTYRT 515
             V    + L   +GA +KV  F+  +        D S  P+H   EG +   ++   Y  
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN 1323

Query: 516  RPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDH 575
                 VL++V   + PG+   + G +GSGKSS          +  G++++DG  IS    
Sbjct: 1324 NLKP-VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1382

Query: 576  KYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
              L   +S++ Q+P+LF+ SI  N+         + + EA + A     +  L  G    
Sbjct: 1383 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTD-DRLWEALEIAQLKNMVKSLPGGLDAV 1441

Query: 636  TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVL 695
              E G   S GQ+Q   +ARA VR   +LI+DEAT+++D  +E ++Q+ +       TV+
Sbjct: 1442 VTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVV 1501

Query: 696  IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQM 742
             IAHR+ T+  A L++V+ +G +++  T + LLAQ  G++A  V+  M
Sbjct: 1502 TIAHRVHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFVRADM 1549



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 69/211 (32%), Positives = 114/211 (54%), Gaps = 12/211 (5%)

Query: 522 LQNVSFSLSPGKVTALVGPSGSGKSSCV-NILENFYPLEGG---RVLLDGKPISAYDHKY 577
           L N+   +  G++T +VG  G GKSS +  IL     LEG      + + +P        
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747

Query: 578 LHRVISLVSQEPVLFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
               ++  +Q+P L   ++ +NI++G P     ++ V +A    +    I  L  G  TE
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTE 804

Query: 636 TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQ--KH 692
            GE+G  LSGGQ+QR+ +ARAL +N  ++ LD+  SALD   S++L+Q+ I   LQ  K 
Sbjct: 805 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 864

Query: 693 TVLIIAHRLSTVEHAHLIVVLDKGRVVQQGT 723
           T++++ H+L  + HA  I+ +  G V+++GT
Sbjct: 865 TLVLVTHKLQYLTHADWIIAMKDGSVLREGT 895


>gi|25914749 ATP-binding cassette, sub-family C, member 10 [Homo
            sapiens]
          Length = 1464

 Score =  151 bits (382), Expect = 2e-36
 Identities = 139/533 (26%), Positives = 249/533 (46%), Gaps = 46/533 (8%)

Query: 232  VCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTS 291
            +C L     FAAG      TL         R  L R L++  T FF+   TG +++R +S
Sbjct: 952  LCTLLRAVLFAAGTLQAAATLH--------RRLLHRVLMAPVT-FFNATPTGRILNRFSS 1002

Query: 292  DTTMVSDLVSQNINVFLRNTVKVTGVVVFMFS-LSWQLSLVTFMGFPIIMMVSNIYGKYY 350
            D     D +   +N+ L N   + G++  + S L W L L+     P+ +M  ++  ++Y
Sbjct: 1003 DVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLP----PLSIMYYHVQ-RHY 1057

Query: 351  KRLSKEVQN----ALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
            +  S+E++      L+   +   +T++ +  +R+        E  LR L+   +     +
Sbjct: 1058 RASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATS 1117

Query: 407  AAYMY-----YVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMES 461
            A   +      + G+ +   +  ++++ +       G    G +   + Y   L   +  
Sbjct: 1118 ATMQWLDIRLQLMGAAVVSAIAGIALVQHQ-----QGLANPGLVGLSLSYALSLTGLLSG 1172

Query: 462  VGSVYSGLMQGVGAAEKVFEFI-------DRQPTMVHDGSLAPDHLEGRVDFENVTFTYR 514
            + S ++     + + E++ E+          QP  +  G L     +G V+F++V   YR
Sbjct: 1173 LVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLT----QGGVEFQDVVLAYR 1228

Query: 515  TRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYD 574
                   L  V+F + PG+   +VG +GSGKSS + +L        GRVLLDG   S  +
Sbjct: 1229 P-GLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLE 1287

Query: 575  HKYLHRVISLVSQEPVLFARSITDNIS-YGLPTVPFEMVVEAAQKANAHGFIMELQDGYS 633
               L   ++++ QEP LF+ ++ +N+   GL     +  +  A K      ++    G  
Sbjct: 1288 LAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHK---DRALWQALKQCHLSEVITSMGGLD 1344

Query: 634  TETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHT 693
             E GE G  LS GQ+Q + +ARAL+ +  +L +DEAT+++D +++ L+QQ I       T
Sbjct: 1345 GELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKT 1404

Query: 694  VLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ-GGLYAKLVQRQMLGL 745
            VL IAHRL+T+ ++  ++VL  GRVV+  +   L  Q   L+ +L+Q    G+
Sbjct: 1405 VLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGV 1457



 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 60/198 (30%), Positives = 102/198 (51%), Gaps = 12/198 (6%)

Query: 532 GKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVL 591
           G +  +VG  G GKSS +  +        G V + G          L +   L +QEP +
Sbjct: 598 GMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRG----------LSKGFGLATQEPWI 647

Query: 592 FARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRV 651
              +I DNI +G  T   ++  E  +    +  +  L  G  TE GEKG  LSGGQ+ R+
Sbjct: 648 QFATIRDNILFG-KTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARI 706

Query: 652 AMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLI 710
           A+ARA+ +   + +LD+  +A+DA+ + +L+ + I G L   T L+  HR   +E A  +
Sbjct: 707 ALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAV 766

Query: 711 VVLDKGRVVQQGTHQQLL 728
           ++++ GR+++ G   ++L
Sbjct: 767 LLMEAGRLIRAGPPSEIL 784


>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A-delta-14 [Homo sapiens]
          Length = 1513

 Score =  147 bits (372), Expect = 3e-35
 Identities = 145/584 (24%), Positives = 254/584 (43%), Gaps = 55/584 (9%)

Query: 187  FLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQF--STAVVIVCLLAIGSSFAAG 244
            +L +  FFL++  +    L +    AID  +   + +    +T          G S   G
Sbjct: 949  YLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCG 1008

Query: 245  IRGGIFTLIFARLNIR---------LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTM 295
               GIF  +   L +          L + L   ++     FFD    G +++R ++DT +
Sbjct: 1009 --AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNI 1066

Query: 296  VSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSK 355
            +   +   +    R+T+     +  M S +  + LV  +   +         KY++  SK
Sbjct: 1067 IDQHIPPTLESLTRSTLLCLSAIG-MISYATPVFLVALLPLGVAFYFIQ---KYFRVASK 1122

Query: 356  EVQNA--------LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAA 407
            ++Q          L   S TAE     + T+R+F +E        R  Q++ +L      
Sbjct: 1123 DLQELDDSTQLPLLCHFSETAE----GLTTIRAFRHET-------RFKQRMLELTDTNNI 1171

Query: 408  AYMYYVWGSGLTLLVVQVSILYYGGHLV-------ISGQMTSGNLIAFIIYEFVLGDCME 460
            AY++    +      ++V   Y G  +V       ISG   SG +   ++Y   + + + 
Sbjct: 1172 AYLFLSAANRW----LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1227

Query: 461  SVGSVYSGLMQGVGAAEKVFEFIDRQPTMVH---DGSLAPDHL--EGRVDFENVTFTYRT 515
             V    + L   +GA +KV  F+  +        D S  P+H   EG +   ++   Y  
Sbjct: 1228 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN 1287

Query: 516  RPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDH 575
                 VL++V   + PG+   + G +GSGKSS          +  G++++DG  IS    
Sbjct: 1288 NLKP-VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1346

Query: 576  KYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
              L   +S++ Q+P+LF+ SI  N+         + + EA + A     +  L  G    
Sbjct: 1347 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTD-DRLWEALEIAQLKNMVKSLPGGLDAV 1405

Query: 636  TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVL 695
              E G   S GQ+Q   +ARA VR   +LI+DEAT+++D  +E ++Q+ +       TV+
Sbjct: 1406 VTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVV 1465

Query: 696  IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLA-QGGLYAKLV 738
             IAHR+S++  A L++V  +G +V+  T   LLA + GL++ LV
Sbjct: 1466 TIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1509



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 69/211 (32%), Positives = 114/211 (54%), Gaps = 12/211 (5%)

Query: 522 LQNVSFSLSPGKVTALVGPSGSGKSSCV-NILENFYPLEGG---RVLLDGKPISAYDHKY 577
           L N+   +  G++T +VG  G GKSS +  IL     LEG      + + +P        
Sbjct: 652 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 711

Query: 578 LHRVISLVSQEPVLFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
               ++  +Q+P L   ++ +NI++G P     ++ V +A    +    I  L  G  TE
Sbjct: 712 NRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTE 768

Query: 636 TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQ--KH 692
            GE+G  LSGGQ+QR+ +ARAL +N  ++ LD+  SALD   S++L+Q+ I   LQ  K 
Sbjct: 769 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 828

Query: 693 TVLIIAHRLSTVEHAHLIVVLDKGRVVQQGT 723
           T++++ H+L  + HA  I+ +  G V+++GT
Sbjct: 829 TLVLVTHKLQYLTHADWIIAMKDGSVLREGT 859


>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
            SUR2A [Homo sapiens]
          Length = 1549

 Score =  147 bits (372), Expect = 3e-35
 Identities = 145/584 (24%), Positives = 254/584 (43%), Gaps = 55/584 (9%)

Query: 187  FLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQF--STAVVIVCLLAIGSSFAAG 244
            +L +  FFL++  +    L +    AID  +   + +    +T          G S   G
Sbjct: 985  YLTSGGFFLLILMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCG 1044

Query: 245  IRGGIFTLIFARLNIR---------LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTM 295
               GIF  +   L +          L + L   ++     FFD    G +++R ++DT +
Sbjct: 1045 --AGIFLCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDTTPLGLILNRFSADTNI 1102

Query: 296  VSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSK 355
            +   +   +    R+T+     +  M S +  + LV  +   +         KY++  SK
Sbjct: 1103 IDQHIPPTLESLTRSTLLCLSAIG-MISYATPVFLVALLPLGVAFYFIQ---KYFRVASK 1158

Query: 356  EVQNA--------LARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAA 407
            ++Q          L   S TAE     + T+R+F +E        R  Q++ +L      
Sbjct: 1159 DLQELDDSTQLPLLCHFSETAE----GLTTIRAFRHET-------RFKQRMLELTDTNNI 1207

Query: 408  AYMYYVWGSGLTLLVVQVSILYYGGHLV-------ISGQMTSGNLIAFIIYEFVLGDCME 460
            AY++    +      ++V   Y G  +V       ISG   SG +   ++Y   + + + 
Sbjct: 1208 AYLFLSAANRW----LEVRTDYLGACIVLTASIASISGSSNSGLVGLGLLYALTITNYLN 1263

Query: 461  SVGSVYSGLMQGVGAAEKVFEFIDRQPTMVH---DGSLAPDHL--EGRVDFENVTFTYRT 515
             V    + L   +GA +KV  F+  +        D S  P+H   EG +   ++   Y  
Sbjct: 1264 WVVRNLADLEVQMGAVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYEN 1323

Query: 516  RPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDH 575
                 VL++V   + PG+   + G +GSGKSS          +  G++++DG  IS    
Sbjct: 1324 NLKP-VLKHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPL 1382

Query: 576  KYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
              L   +S++ Q+P+LF+ SI  N+         + + EA + A     +  L  G    
Sbjct: 1383 HTLRSRLSIILQDPILFSGSIRFNLDPECKCTD-DRLWEALEIAQLKNMVKSLPGGLDAV 1441

Query: 636  TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVL 695
              E G   S GQ+Q   +ARA VR   +LI+DEAT+++D  +E ++Q+ +       TV+
Sbjct: 1442 VTEGGENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVV 1501

Query: 696  IIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLA-QGGLYAKLV 738
             IAHR+S++  A L++V  +G +V+  T   LLA + GL++ LV
Sbjct: 1502 TIAHRVSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFSTLV 1545



 Score = 97.8 bits (242), Expect = 3e-20
 Identities = 69/211 (32%), Positives = 114/211 (54%), Gaps = 12/211 (5%)

Query: 522 LQNVSFSLSPGKVTALVGPSGSGKSSCV-NILENFYPLEGG---RVLLDGKPISAYDHKY 577
           L N+   +  G++T +VG  G GKSS +  IL     LEG      + + +P        
Sbjct: 688 LSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSR 747

Query: 578 LHRVISLVSQEPVLFARSITDNISYGLP--TVPFEMVVEAAQKANAHGFIMELQDGYSTE 635
               ++  +Q+P L   ++ +NI++G P     ++ V +A    +    I  L  G  TE
Sbjct: 748 NRYSVAYAAQKPWLLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTE 804

Query: 636 TGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQ--KH 692
            GE+G  LSGGQ+QR+ +ARAL +N  ++ LD+  SALD   S++L+Q+ I   LQ  K 
Sbjct: 805 IGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKR 864

Query: 693 TVLIIAHRLSTVEHAHLIVVLDKGRVVQQGT 723
           T++++ H+L  + HA  I+ +  G V+++GT
Sbjct: 865 TLVLVTHKLQYLTHADWIIAMKDGSVLREGT 895


>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
            [Homo sapiens]
          Length = 1527

 Score =  146 bits (369), Expect = 6e-35
 Identities = 126/520 (24%), Positives = 235/520 (45%), Gaps = 32/520 (6%)

Query: 235  LAIGSSFAAGIRGGIFTLIFARLNIR--------LRNCLFRSLVSQETSFFDENRTGDLI 286
            L +G   A GI  G   ++ A             L   L  + +    SFFD   +G ++
Sbjct: 1010 LRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRIL 1069

Query: 287  SRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIY 346
            +  + D  +V ++++  I + L +       +V + + +   ++V      +  +V   Y
Sbjct: 1070 NCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFY 1129

Query: 347  GKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA 406
                ++L +    + +   +   ET++    +R++ N   + E+         K++  + 
Sbjct: 1130 AATSRQLKRLESVSRSPIYSHFSETVTGASVIRAY-NRSRDFEIISDT-----KVDANQR 1183

Query: 407  AAYMYYVWGSGLTLLVVQVS---ILYYGGHLVISGQMTSGNLIAFII-YEFVLGDCMESV 462
            + Y Y +    L++ V  V    +L+     VI     +  L+   + Y   +   +  +
Sbjct: 1184 SCYPYIISNRWLSIGVEFVGNCVVLFAALFAVIGRSSLNPGLVGLSVSYSLQVTFALNWM 1243

Query: 463  GSVYSGLMQGVGAAEKVFEF--IDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQ 520
              + S L   + A E+V E+   + +   V +GS  P+    R + E   ++ R RP   
Sbjct: 1244 IRMMSDLESNIVAVERVKEYSKTETEAPWVVEGSRPPEGWPPRGEVEFRNYSVRYRPGLD 1303

Query: 521  -VLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLH 579
             VL+++S  +  G+   +VG +G+GKSS    L        G + +DG  ++      L 
Sbjct: 1304 LVLRDLSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLR 1363

Query: 580  RVISLVSQEPVLFARSITDNISYGLPTVPFEMVVE-----AAQKANAHGFIMELQDGYST 634
              ++++ Q+P+LF+ ++  N+       PF    E     A + ++ H F+     G   
Sbjct: 1364 SQLTIIPQDPILFSGTLRMNLD------PFGSYSEEDIWWALELSHLHTFVSSQPAGLDF 1417

Query: 635  ETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTV 694
            +  E G  LS GQ+Q V +ARAL+R   +L+LDEAT+A+D E++ LIQ  I       TV
Sbjct: 1418 QCSEGGENLSVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTV 1477

Query: 695  LIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLY 734
            L IAHRL+T+     ++VLDKG V +  +   L+A  G++
Sbjct: 1478 LTIAHRLNTIMDYTRVLVLDKGVVAEFDSPANLIAARGIF 1517



 Score = 96.7 bits (239), Expect = 7e-20
 Identities = 125/590 (21%), Positives = 260/590 (44%), Gaps = 85/590 (14%)

Query: 174 LQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIV- 232
           +Q LLS+  P +         +++  +     P + G  + G++   SM Q   ++++  
Sbjct: 320 IQDLLSFINPQL-------LSILIRFISNPMAPSWWGFLVAGLMFLCSMMQ---SLILQH 369

Query: 233 ---CLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRL 289
               +   G  F  GI G I+     R  + + N + R+           +  G++++ +
Sbjct: 370 YYHYIFVTGVKFRTGIMGVIY-----RKALVITNSVKRA-----------STVGEIVNLM 413

Query: 290 TSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIY 346
           + D     DL +  +N+     +++   + F+    WQ    S++  + F ++++  N  
Sbjct: 414 SVDAQRFMDL-APFLNLLWSAPLQIILAIYFL----WQNLGPSVLAGVAFMVLLIPLNGA 468

Query: 347 GKYYKRLSKEVQNALARAS-NTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYK--LNR 403
                R  +  Q  L  +      E ++ +K ++ +A E      +L++++ + +  L  
Sbjct: 469 VAVKMRAFQVKQMKLKDSRIKLMSEILNGIKVLKLYAWEPS----FLKQVEGIRQGELQL 524

Query: 404 KEAAAYMY----YVWGSG---LTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLG 456
              AAY++    + W      +TL+ + V + Y   + V+  +    ++  F I    L 
Sbjct: 525 LRTAAYLHTTTTFTWMCSPFLVTLITLWVYV-YVDPNNVLDAEKAFVSVSLFNILRLPLN 583

Query: 457 DCMESVGSVYSGLMQGVGAAEKVFEFIDRQ---PTMVHDGSLAPDHLEGRVDFENVTFTY 513
                +  + S L Q   + +++ +F+ ++   P  V   +++P +    +   + TFT+
Sbjct: 584 ----MLPQLISNLTQASVSLKRIQQFLSQEELDPQSVERKTISPGYA---ITIHSGTFTW 636

Query: 514 RTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAY 573
             +     L ++   +  G + A+VGP G GKSS V+ L        G+V + G      
Sbjct: 637 -AQDLPPTLHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS----- 690

Query: 574 DHKYLHRVISLVSQEPVLFARSITDNISYGLPTVP--FEMVVEAAQKANAHGFIMELQDG 631
                   ++ V Q+  +   ++ +N+ +G    P  ++  +EA         +  L  G
Sbjct: 691 --------VAYVPQQAWIQNCTLQENVLFGKALNPKRYQQTLEACALL---ADLEMLPGG 739

Query: 632 YSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAE-SEYLIQQAI--HGN 688
             TE GEKG  LSGGQ+QRV++ARA+  +  + +LD+  SA+D+  ++++    I   G 
Sbjct: 740 DQTEIGEKGINLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGV 799

Query: 689 LQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLV 738
           L   T +++ H +S +     I+VL  G+V + G +  LL + G +A  +
Sbjct: 800 LAGKTRVLVTHGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFL 849


>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 1312

 Score =  144 bits (362), Expect = 4e-34
 Identities = 141/533 (26%), Positives = 241/533 (45%), Gaps = 48/533 (9%)

Query: 233  CLLAIG--SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLT 290
            CL AIG  +S AA + GG      AR +  L   L   +V    SFF+    G L++R +
Sbjct: 805  CLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFS 858

Query: 291  SDTTMVSDLVSQNINVFLR---NTVKVTGVVVFMFSLSWQLSLVTFM---GFPIIMMVSN 344
             +T  V   +   +   L      ++V+ VV     L+    L  F+   GF  + +VS+
Sbjct: 859  KETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 918

Query: 345  IYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRK 404
                   +L +    + +   +   ET      VR+F  +         ++ +  +++  
Sbjct: 919  C------QLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFP 972

Query: 405  EAAAYMYY-----VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDC 458
               A  +      + G+GL       ++L        S    S  L+ F +   + +   
Sbjct: 973  RLVADRWLAANVELLGNGLVFAAATCAVL--------SKAHLSAGLVGFSVSAALQVTQT 1024

Query: 459  MESVGSVYSGLMQGVGAAEKVFEFID-------RQPTMVHDGSLAPDHLEGRVDFENVTF 511
            ++ V   ++ L   + + E++ ++         R PT     +  P    G+++F++  F
Sbjct: 1025 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA---AQPPWPQGGQIEFQD--F 1079

Query: 512  TYRTRPHTQV-LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
              R RP   + +Q VSF +  G+   +VG +G+GKSS  + L        G + +DG PI
Sbjct: 1080 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1139

Query: 571  SAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQD 630
            +      L   IS++ Q+P+LF  S+  N+   L     E +  A +       +  L  
Sbjct: 1140 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKALVASLPG 1198

Query: 631  GYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ 690
                +  ++G  LS GQKQ + +ARAL+R   +LILDEAT+A+D  +E  +Q  +     
Sbjct: 1199 QLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFA 1258

Query: 691  KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
            + TVL+IAHRL +V     ++V+DKG+V + G+  QLLAQ GL+ +L Q   L
Sbjct: 1259 QCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1311



 Score =  102 bits (255), Expect = 1e-21
 Identities = 118/520 (22%), Positives = 228/520 (43%), Gaps = 47/520 (9%)

Query: 257 LNIRLRNCL----FRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTV 312
           L +RLR+ +    +R +++  +     +  GD+++ ++ D   +++ V     ++L    
Sbjct: 186 LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESV-----LYLNGLW 240

Query: 313 KVTGVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAE 369
                +V  F   WQL   S +T +   + ++  N +    K+ +   +  + +  + A 
Sbjct: 241 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFF--ISKKRNHHQEEQMRQKDSRAR 298

Query: 370 ETISAMKTVRSFANEEEEAEVYLRKLQ-QVYKLNRKEAAAYMYYVWGSGLTLLVVQVSIL 428
            T S ++  ++      E     R L  +  +L     +  ++ V      +    V+++
Sbjct: 299 LTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALV 358

Query: 429 YYGGH-LVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFI---D 484
            +  H LV    M +      +    +L      +      L+Q   + +++  F+   +
Sbjct: 359 VFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE 418

Query: 485 RQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSG 544
             P  V   S      +  +  ++ TF + ++     L  ++ ++  G + A+VGP G+G
Sbjct: 419 VDPGAVDSSSSGSAAGKDCITIQSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAG 477

Query: 545 KSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGL 604
           KSS ++ L        G V ++G              ++ V QE  +   S+ +N+ +G 
Sbjct: 478 KSSLLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQ 524

Query: 605 PTVP--FEMVVEA-AQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNP 661
              P   E V+EA A + +   F     +G  T  GE+G  LSGGQKQR+++ARA+ R  
Sbjct: 525 ELDPPWLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKA 580

Query: 662 PVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRV 718
            V +LD+  +ALDA   +++  Q I   G LQ  T +++ H L  +  A  I+VL  G +
Sbjct: 581 AVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAI 640

Query: 719 VQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEP 758
            + G++Q+LL + G    L+ +     QP  D   G  EP
Sbjct: 641 AEMGSYQELLQRKGALVCLLDQ---ARQP-GDRGEGETEP 676


>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
            [Homo sapiens]
          Length = 1503

 Score =  143 bits (360), Expect = 7e-34
 Identities = 141/533 (26%), Positives = 240/533 (45%), Gaps = 48/533 (9%)

Query: 233  CLLAIG--SSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLT 290
            CL AIG  +S AA + GG      AR +  L   L   +V    SFF+    G L++R +
Sbjct: 996  CLQAIGLFASMAAVLLGG------ARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFS 1049

Query: 291  SDTTMVSDLVSQNINVFLR---NTVKVTGVVVFMFSLSWQLSLVTFM---GFPIIMMVSN 344
             +T  V   +   +   L      ++V+ VV     L+    L  F+   GF  + +VS+
Sbjct: 1050 KETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1109

Query: 345  IYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRK 404
                   +L +    + +   +   ET      VR+F  +         ++ +  +++  
Sbjct: 1110 C------QLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFP 1163

Query: 405  EAAAYMYY-----VWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFV-LGDC 458
               A  +      + G+GL       ++L        S    S  L+ F +   + +   
Sbjct: 1164 RLVADRWLAANVELLGNGLVFAAATCAVL--------SKAHLSAGLVGFSVSAALQVTQT 1215

Query: 459  MESVGSVYSGLMQGVGAAEKVFEFID-------RQPTMVHDGSLAPDHLEGRVDFENVTF 511
            ++ V   ++ L   + + E++ ++         R PT     +  P    G+++F +  F
Sbjct: 1216 LQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCA---AQPPWPQGGQIEFRD--F 1270

Query: 512  TYRTRPHTQV-LQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPI 570
              R RP   + +Q VSF +  G+   +VG +G+GKSS  + L        G + +DG PI
Sbjct: 1271 GLRYRPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPI 1330

Query: 571  SAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQD 630
            +      L   IS++ Q+P+LF  S+  N+   L     E +  A +       +  L  
Sbjct: 1331 AHVGLHTLRSRISIIPQDPILFPGSLRMNLDL-LQEHSDEAIWAALETVQLKALVASLPG 1389

Query: 631  GYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQ 690
                +  ++G  LS GQKQ + +ARAL+R   +LILDEAT+A+D  +E  +Q  +     
Sbjct: 1390 QLQYKCADRGEDLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFA 1449

Query: 691  KHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQML 743
            + TVL+IAHRL +V     ++V+DKG+V + G+  QLLAQ GL+ +L Q   L
Sbjct: 1450 QCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRLAQESGL 1502



 Score =  102 bits (255), Expect = 1e-21
 Identities = 118/520 (22%), Positives = 228/520 (43%), Gaps = 47/520 (9%)

Query: 257 LNIRLRNCL----FRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTV 312
           L +RLR+ +    +R +++  +     +  GD+++ ++ D   +++ V     ++L    
Sbjct: 377 LQMRLRSAITGLVYRKVLALSSGSRKASAVGDVVNLVSVDVQRLTESV-----LYLNGLW 431

Query: 313 KVTGVVVFMFSLSWQL---SLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAE 369
                +V  F   WQL   S +T +   + ++  N +    K+ +   +  + +  + A 
Sbjct: 432 LPLVWIVVCFVYLWQLLGPSALTAIAVFLSLLPLNFF--ISKKRNHHQEEQMRQKDSRAR 489

Query: 370 ETISAMKTVRSFANEEEEAEVYLRKLQ-QVYKLNRKEAAAYMYYVWGSGLTLLVVQVSIL 428
            T S ++  ++      E     R L  +  +L     +  ++ V      +    V+++
Sbjct: 490 LTSSILRNSKTIKFHGWEGAFLDRVLGIRGQELGALRTSGLLFSVSLVSFQVSTFLVALV 549

Query: 429 YYGGH-LVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFI---D 484
            +  H LV    M +      +    +L      +      L+Q   + +++  F+   +
Sbjct: 550 VFAVHTLVAENAMNAEKAFVTLTVLNILNKAQAFLPFSIHSLVQARVSFDRLVTFLCLEE 609

Query: 485 RQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSG 544
             P +V   S      +  +   + TF + ++     L  ++ ++  G + A+VGP G+G
Sbjct: 610 VDPGVVDSSSSGSAAGKDCITIHSATFAW-SQESPPCLHRINLTVPQGCLLAVVGPVGAG 668

Query: 545 KSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGL 604
           KSS ++ L        G V ++G              ++ V QE  +   S+ +N+ +G 
Sbjct: 669 KSSLLSALLGELSKVEGFVSIEG-------------AVAYVPQEAWVQNTSVVENVCFGQ 715

Query: 605 PTVP--FEMVVEA-AQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNP 661
              P   E V+EA A + +   F     +G  T  GE+G  LSGGQKQR+++ARA+ R  
Sbjct: 716 ELDPPWLERVLEACALQPDVDSF----PEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKA 771

Query: 662 PVLILDEATSALDAE-SEYLIQQAI--HGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRV 718
            V +LD+  +ALDA   +++  Q I   G LQ  T +++ H L  +  A  I+VL  G +
Sbjct: 772 AVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAI 831

Query: 719 VQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEP 758
            + G++Q+LL + G    L+ +     QP  D   G  EP
Sbjct: 832 AEMGSYQELLQRKGALVCLLDQ---ARQP-GDRGEGETEP 867


>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
            [Homo sapiens]
          Length = 1325

 Score =  140 bits (354), Expect = 3e-33
 Identities = 128/513 (24%), Positives = 242/513 (47%), Gaps = 45/513 (8%)

Query: 261  LRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVF 320
            L N +F S++     FFD N  G +++R + D   + DL+      F++  ++V GVV  
Sbjct: 797  LHNKMFESILKAPVLFFDRNPIGRILNRFSKDIGHLDDLLPLTFLDFIQTLLQVVGVV-- 854

Query: 321  MFSLSWQLSLVTFMGFPIIMM--VSNIYGKYYKRLSKEVQNALARASNTA----EETISA 374
                S  ++++ ++  P++ +  +     +Y+   S++V+   +   +        ++  
Sbjct: 855  ----SVAVAVIPWIAIPLVPLGIIFIFLRRYFLETSRDVKRLESTTRSPVFSHLSSSLQG 910

Query: 375  MKTVRSFANEEEEAEVYLRKLQQVYKLNRK-EAAAYMYYVWGSG-----LTLLVVQVSIL 428
            + T+R++  EE        + Q+++  ++   + A+  ++  S      L  +     I+
Sbjct: 911  LWTIRAYKAEE--------RCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAMFVII 962

Query: 429  YYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPT 488
               G L+++  + +G +   + Y   L    +      + +   + + E+V E+ D +  
Sbjct: 963  VAFGSLILAKTLDAGQVGLALSYALTLMGMFQWCVRQSAEVENMMISVERVIEYTDLEKE 1022

Query: 489  MVHDGSLAPDHL---EGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGK 545
               +    P      EG + F+NV F Y +     VL++++  +   +   +VG +G+GK
Sbjct: 1023 APWEYQKRPPPAWPHEGVIIFDNVNFMY-SPGGPLVLKHLTALIKSQEKVGIVGRTGAGK 1081

Query: 546  SSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLP 605
            SS ++ L      EG ++ +D    +      L + +S++ QEPVLF  ++  N+     
Sbjct: 1082 SSLISALFRLSEPEG-KIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLD---- 1136

Query: 606  TVPF-----EMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRN 660
              PF     E +  A Q+      I +L     TE  E G+  S GQ+Q V +ARA++R 
Sbjct: 1137 --PFNEHTDEELWNALQEVQLKETIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILRK 1194

Query: 661  PPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQ 720
              +LI+DEAT+ +D  ++ LIQ+ I       TVL IAHRL+T+  +  I+VLD GR+ +
Sbjct: 1195 NQILIIDEATANVDPRTDELIQKKIREKFAHCTVLTIAHRLNTIIDSDKIMVLDSGRLKE 1254

Query: 721  QGTHQQLLA-QGGLYAKLVQRQMLGLQPAADFT 752
                  LL  +  L+ K+VQ+  LG   AA  T
Sbjct: 1255 YDEPYVLLQNKESLFYKMVQQ--LGKAEAAALT 1285



 Score =  128 bits (322), Expect = 2e-29
 Identities = 131/571 (22%), Positives = 257/571 (45%), Gaps = 44/571 (7%)

Query: 186 AFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQ--FSTAVVIVCLLAIGSSFAA 243
           ++LV   F LI  +  +   P + G+ I+       MD    +TA     +L   +   A
Sbjct: 91  SYLVLGIFTLIEES-AKVIQPIFLGKIINYFENYDPMDSVALNTAYAYATVLTFCTLILA 149

Query: 244 GIRGGIFTLIFA---RLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLV 300
            +    F  +     RL + + + ++R  +        +  TG +++ L++D        
Sbjct: 150 ILHHLYFYHVQCAGMRLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKFDQ-- 207

Query: 301 SQNINVFLRNTVKVTGVVVFMFSLSWQ---LSLVTFMGFPIIMM-VSNIYGKYYKRLSKE 356
              + VFL          + + +L W    +S +  M   II++ + + +GK +  L  +
Sbjct: 208 ---VTVFLHFLWAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSK 264

Query: 357 VQNALARASNTAEETISAMKTVRSFANEEEEAEVY--LRKLQQVYKLNRKEAAAYMYYVW 414
                     T  E I+ ++ ++ +A E+  + +   LRK +++ K+ R      M    
Sbjct: 265 TATFTDARIRTMNEVITGIRIIKMYAWEKSFSNLITNLRK-KEISKILRSSCLRGMNLAS 323

Query: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGN--LIAFIIYEFVLGDCMESVGSVYSGLMQG 472
               + ++V V+   Y    V+ G + + +   +A  +Y  V         S    + + 
Sbjct: 324 FFSASKIIVFVTFTTY----VLLGSVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEA 379

Query: 473 VGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 532
           + +  ++  F+        +  L  D  +  V  ++ T  +     T  LQ +SF++ PG
Sbjct: 380 IVSIRRIQTFLLLDEISQRNRQLPSDGKK-MVHVQDFTAFWDKASETPTLQGLSFTVRPG 438

Query: 533 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 592
           ++ A+VGP G+GKSS ++ +        G V + G+             I+ VSQ+P +F
Sbjct: 439 ELLAVVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVF 485

Query: 593 ARSITDNISYG--LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQR 650
           + ++  NI +G       +E V++A         +  L+DG  T  G++G  LSGGQK R
Sbjct: 486 SGTLRSNILFGKKYEKERYEKVIKACALKKD---LQLLEDGDLTVIGDRGTTLSGGQKAR 542

Query: 651 VAMARALVRNPPVLILDEATSALDAE-SEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHL 709
           V +ARA+ ++  + +LD+  SA+DAE S +L +  I   L +   +++ H+L  ++ A  
Sbjct: 543 VNLARAVYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQ 602

Query: 710 IVVLDKGRVVQQGTHQQLLAQGGLYAKLVQR 740
           I++L  G++VQ+GT+ + L  G  +  L+++
Sbjct: 603 ILILKDGKMVQKGTYTEFLKSGIDFGSLLKK 633


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.137    0.401 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,330,699
Number of Sequences: 37866
Number of extensions: 1109504
Number of successful extensions: 3823
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 88
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 3473
Number of HSP's gapped (non-prelim): 214
length of query: 766
length of database: 18,247,518
effective HSP length: 110
effective length of query: 656
effective length of database: 14,082,258
effective search space: 9237961248
effective search space used: 9237961248
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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