Search of human proteins with 45238849

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|45238849 poly(A) binding protein, cytoplasmic 3 [Homo
sapiens]
         (631 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|45238849 poly(A) binding protein, cytoplasmic 3 [Homo sapiens]    1254   0.0  
gi|46367787 poly(A) binding protein, cytoplasmic 1 [Homo sapiens]    1151   0.0  
gi|208431836 poly A binding protein, cytoplasmic 4 isoform 3 [Ho...   881   0.0  
gi|4504715 poly A binding protein, cytoplasmic 4 isoform 2 [Homo...   876   0.0  
gi|208431833 poly A binding protein, cytoplasmic 4 isoform 1 [Ho...   871   0.0  
gi|185135971 poly(A)-binding protein, cytoplasmic 1-like [Homo s...   790   0.0  
gi|168229150 poly(A) binding protein, cytoplasmic 4-like [Homo s...   511   e-144
gi|18201888 poly(A) binding protein, cytoplasmic 5 [Homo sapiens]     451   e-127
gi|109948285 poly(A) binding protein, cytoplasmic 1-like 2B [Hom...   293   3e-79
gi|61175237 poly(A) binding protein, cytoplasmic 1-like 2A [Homo...   293   3e-79
gi|239753150 PREDICTED: similar to poly(A) binding protein, cyto...   140   4e-33
gi|188219591 TIA1 protein isoform 2 [Homo sapiens]                    120   5e-27
gi|4507499 TIA-1 related protein isoform 1 [Homo sapiens]             119   8e-27
gi|188219593 TIA1 protein isoform 1 [Homo sapiens]                    117   2e-26
gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]               114   3e-25
gi|38201714 ELAV-like 1 [Homo sapiens]                                112   1e-24
gi|77695912 TIA-1 related protein isoform 2 [Homo sapiens]            111   2e-24
gi|55956788 nucleolin [Homo sapiens]                                  103   6e-22
gi|115511032 ELAV (embryonic lethal, abnormal vision, Drosophila...   102   1e-21
gi|221316773 ELAV-like 4 isoform 5 [Homo sapiens]                      99   2e-20
gi|221316771 ELAV-like 4 isoform 4 [Homo sapiens]                      99   2e-20
gi|221316769 ELAV-like 4 isoform 3 [Homo sapiens]                      99   2e-20
gi|221316767 ELAV-like 4 isoform 2 [Homo sapiens]                      99   2e-20
gi|49355765 ELAV-like protein 3 isoform 2 [Homo sapiens]               97   3e-20
gi|209862867 poly-U binding splicing factor 60KDa isoform c [Hom...    94   5e-19
gi|17978512 poly-U binding splicing factor 60KDa isoform a [Homo...    94   5e-19
gi|17298690 poly-U binding splicing factor 60KDa isoform b [Homo...    92   2e-18
gi|228008400 synaptotagmin binding, cytoplasmic RNA interacting ...    89   1e-17
gi|228008396 synaptotagmin binding, cytoplasmic RNA interacting ...    89   1e-17
gi|228008293 synaptotagmin binding, cytoplasmic RNA interacting ...    89   1e-17

>gi|45238849 poly(A) binding protein, cytoplasmic 3 [Homo sapiens]
          Length = 631

 Score = 1254 bits (3246), Expect = 0.0
 Identities = 631/631 (100%), Positives = 631/631 (100%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ
Sbjct: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS 120
           HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS
Sbjct: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS 120

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180
           AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE
Sbjct: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180

Query: 181 AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER 240
           AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER
Sbjct: 181 AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER 240

Query: 241 HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN 300
           HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN
Sbjct: 241 HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN 300

Query: 301 LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT 360
           LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT
Sbjct: 301 LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT 360

Query: 361 KPLYVALAQRKEERQAYLTNEYMQRMASVRAVPNQRAPPSGYFMTAVPQTQNHAAYYPPS 420
           KPLYVALAQRKEERQAYLTNEYMQRMASVRAVPNQRAPPSGYFMTAVPQTQNHAAYYPPS
Sbjct: 361 KPLYVALAQRKEERQAYLTNEYMQRMASVRAVPNQRAPPSGYFMTAVPQTQNHAAYYPPS 420

Query: 421 QIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPRVMSTQRVANTS 480
           QIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPRVMSTQRVANTS
Sbjct: 421 QIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPRVMSTQRVANTS 480

Query: 481 TQTVGPRPAAAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQPQVTMQQLAVHVQGQETL 540
           TQTVGPRPAAAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQPQVTMQQLAVHVQGQETL
Sbjct: 481 TQTVGPRPAAAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQPQVTMQQLAVHVQGQETL 540

Query: 541 TASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLESPESLRS 600
           TASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLESPESLRS
Sbjct: 541 TASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLESPESLRS 600

Query: 601 KVDEAVAVLQAHQAKEATQKAVNSATGVPTV 631
           KVDEAVAVLQAHQAKEATQKAVNSATGVPTV
Sbjct: 601 KVDEAVAVLQAHQAKEATQKAVNSATGVPTV 631


>gi|46367787 poly(A) binding protein, cytoplasmic 1 [Homo sapiens]
          Length = 636

 Score = 1151 bits (2978), Expect = 0.0
 Identities = 586/637 (91%), Positives = 600/637 (94%), Gaps = 7/637 (1%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           MNPS PSYP ASLYVGDLHPDVTEAMLYEKFSPAGPILSIR+CRD+IT  S  YAYVNFQ
Sbjct: 1   MNPSAPSYPMASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDMITRRSLGYAYVNFQ 60

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS 120
              DAE ALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIF+KNLDKSI+NKALYDT S
Sbjct: 61  QPADAERALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFIKNLDKSIDNKALYDTFS 120

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180
           AFGNILSC VVCDENGSKGYGFVHFET EAAERAI+KMNGMLLN RKVFVG+FKSRKERE
Sbjct: 121 AFGNILSCKVVCDENGSKGYGFVHFETQEAAERAIEKMNGMLLNDRKVFVGRFKSRKERE 180

Query: 181 AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER 240
           AELGARAKEF NVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER
Sbjct: 181 AELGARAKEFTNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER 240

Query: 241 HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN 300
           HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKR FEQMKQDRITRYQ VNLYVKN
Sbjct: 241 HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRKFEQMKQDRITRYQGVNLYVKN 300

Query: 301 LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT 360
           LDDGIDDERLRK FSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT
Sbjct: 301 LDDGIDDERLRKEFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT 360

Query: 361 KPLYVALAQRKEERQAYLTNEYMQRMASVRAVPN------QRAPPSGYFMTAVPQTQNHA 414
           KPLYVALAQRKEERQA+LTN+YMQRMASVRAVPN      Q APPSGYFM A+PQTQN A
Sbjct: 361 KPLYVALAQRKEERQAHLTNQYMQRMASVRAVPNPVINPYQPAPPSGYFMAAIPQTQNRA 420

Query: 415 AYYPPSQIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPRVMSTQ 474
           AYYPPSQIA+LRPSPRWTAQGARPHPFQN P AIRP APR PFSTMRPASSQVPRVMSTQ
Sbjct: 421 AYYPPSQIAQLRPSPRWTAQGARPHPFQNMPGAIRPAAPRPPFSTMRPASSQVPRVMSTQ 480

Query: 475 RVANTSTQTVGPRPAAAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQPQVTMQQLAVHV 534
           RVANTSTQT+GPRP AAAAAAATPAVRTVP+YKYAAGVRNPQQH NAQPQVTMQQ AVHV
Sbjct: 481 RVANTSTQTMGPRP-AAAAAAATPAVRTVPQYKYAAGVRNPQQHLNAQPQVTMQQPAVHV 539

Query: 535 QGQETLTASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLES 594
           QGQE LTAS LASAPPQ+QKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELL+MLES
Sbjct: 540 QGQEPLTASMLASAPPQEQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLHMLES 599

Query: 595 PESLRSKVDEAVAVLQAHQAKEATQKAVNSATGVPTV 631
           PESLRSKVDEAVAVLQAHQAKEA QKAVNSATGVPTV
Sbjct: 600 PESLRSKVDEAVAVLQAHQAKEAAQKAVNSATGVPTV 636


>gi|208431836 poly A binding protein, cytoplasmic 4 isoform 3 [Homo
           sapiens]
          Length = 631

 Score =  881 bits (2276), Expect = 0.0
 Identities = 468/641 (73%), Positives = 525/641 (81%), Gaps = 26/641 (4%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           MN +  SYP ASLYVGDLH DVTEAMLYEKFSPAGP+LSIR+CRD+IT  S  YAYVNFQ
Sbjct: 1   MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQ 60

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS 120
              DAE ALDTMNFDVIKGKP+RIMWSQRDPSLRKSGVGN+F+KNLDKSI+NKALYDT S
Sbjct: 61  QPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFS 120

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180
           AFGNILSC VVCDENGSKGY FVHFET EAA++AI+KMNGMLLN RKVFVG+FKSRKERE
Sbjct: 121 AFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKERE 180

Query: 181 AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER 240
           AELGA+AKEF NVYIKNFGE++DDE LK+LF +FG  LSVKVM D +GKSKGFGFVS+E+
Sbjct: 181 AELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEK 240

Query: 241 HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN 300
           HEDA KAV+EMNGKE++GK I+VGRAQKKVERQ ELKR FEQ+KQ+RI+RYQ VNLY+KN
Sbjct: 241 HEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKN 300

Query: 301 LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT 360
           LDD IDDE+LRK FSPFG+ITSAKVM+E GRSKGFGFVCFSSPEEATKAVTEMNGRIV +
Sbjct: 301 LDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGS 360

Query: 361 KPLYVALAQRKEERQAYLTNEYMQRMASVRAVP-----NQRAPPS-GYFMTAVPQTQNHA 414
           KPLYVALAQRKEER+A+LTN+YMQR+A +RA+P     NQ  P + GYF+ AVPQ Q   
Sbjct: 361 KPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRP 420

Query: 415 AYYPPSQIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTM-----RPASSQVPR 469
            YY P+Q+A++RP+PRW  QG RP  FQ  PSAIR   PR     +      PAS  +P 
Sbjct: 421 PYYTPNQLAQMRPNPRW-QQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGNAPASRGLP- 478

Query: 470 VMSTQRV-ANTSTQTVGPRPAAAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQPQVTMQ 528
             +TQRV   T+ Q + PR A AAAA      R V  YKYA+ VR+P  H   QP +   
Sbjct: 479 -TTTQRVGVPTAVQNLAPRAAVAAAAP-----RAVAPYKYASSVRSP--HPAIQP-LQAP 529

Query: 529 QLAVHVQGQETLTASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSEL 588
           Q AVHVQGQE LTAS LA+APPQ+QKQMLGERLFPLIQ MH  LAGKITGMLLEIDNSEL
Sbjct: 530 QPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLEIDNSEL 589

Query: 589 LYMLESPESLRSKVDEAVAVLQAHQA-KEATQK--AVNSAT 626
           L+MLESPESLRSKVDEAVAVLQAH A KEA QK  AV +AT
Sbjct: 590 LHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAAT 630


>gi|4504715 poly A binding protein, cytoplasmic 4 isoform 2 [Homo
           sapiens]
          Length = 644

 Score =  876 bits (2264), Expect = 0.0
 Identities = 464/647 (71%), Positives = 522/647 (80%), Gaps = 25/647 (3%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           MN +  SYP ASLYVGDLH DVTEAMLYEKFSPAGP+LSIR+CRD+IT  S  YAYVNFQ
Sbjct: 1   MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQ 60

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS 120
              DAE ALDTMNFDVIKGKP+RIMWSQRDPSLRKSGVGN+F+KNLDKSI+NKALYDT S
Sbjct: 61  QPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFS 120

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180
           AFGNILSC VVCDENGSKGY FVHFET EAA++AI+KMNGMLLN RKVFVG+FKSRKERE
Sbjct: 121 AFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKERE 180

Query: 181 AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER 240
           AELGA+AKEF NVYIKNFGE++DDE LK+LF +FG  LSVKVM D +GKSKGFGFVS+E+
Sbjct: 181 AELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEK 240

Query: 241 HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN 300
           HEDA KAV+EMNGKE++GK I+VGRAQKKVERQ ELKR FEQ+KQ+RI+RYQ VNLY+KN
Sbjct: 241 HEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKN 300

Query: 301 LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT 360
           LDD IDDE+LRK FSPFG+ITSAKVM+E GRSKGFGFVCFSSPEEATKAVTEMNGRIV +
Sbjct: 301 LDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGS 360

Query: 361 KPLYVALAQRKEERQAYLTNEYMQRMASVRAVP-----NQRAPPS-GYFMTAVPQTQNHA 414
           KPLYVALAQRKEER+A+LTN+YMQR+A +RA+P     NQ  P + GYF+ AVPQ Q   
Sbjct: 361 KPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRP 420

Query: 415 AYYPPSQIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPRVM--- 471
            YY P+Q+A++RP+PRW  QG RP  FQ  PSAIR   PR     + P  S+ P  +   
Sbjct: 421 PYYTPNQLAQMRPNPRW-QQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGSECPDRLAMD 479

Query: 472 -----STQRVANTSTQTVGPRPA----AAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQ 522
                + Q+    S Q+ G   A    A  AA A  A R V  YKYA+ VR+P  H   Q
Sbjct: 480 FGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAPRAVAPYKYASSVRSP--HPAIQ 537

Query: 523 PQVTMQQLAVHVQGQETLTASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLE 582
           P +   Q AVHVQGQE LTAS LA+APPQ+QKQMLGERLFPLIQ MH  LAGKITGMLLE
Sbjct: 538 P-LQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGERLFPLIQTMHSNLAGKITGMLLE 596

Query: 583 IDNSELLYMLESPESLRSKVDEAVAVLQAHQA-KEATQK--AVNSAT 626
           IDNSELL+MLESPESLRSKVDEAVAVLQAH A KEA QK  AV +AT
Sbjct: 597 IDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAAQKVGAVAAAT 643


>gi|208431833 poly A binding protein, cytoplasmic 4 isoform 1 [Homo
           sapiens]
          Length = 660

 Score =  871 bits (2250), Expect = 0.0
 Identities = 468/670 (69%), Positives = 526/670 (78%), Gaps = 55/670 (8%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           MN +  SYP ASLYVGDLH DVTEAMLYEKFSPAGP+LSIR+CRD+IT  S  YAYVNFQ
Sbjct: 1   MNAAASSYPMASLYVGDLHSDVTEAMLYEKFSPAGPVLSIRVCRDMITRRSLGYAYVNFQ 60

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS 120
              DAE ALDTMNFDVIKGKP+RIMWSQRDPSLRKSGVGN+F+KNLDKSI+NKALYDT S
Sbjct: 61  QPADAERALDTMNFDVIKGKPIRIMWSQRDPSLRKSGVGNVFIKNLDKSIDNKALYDTFS 120

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180
           AFGNILSC VVCDENGSKGY FVHFET EAA++AI+KMNGMLLN RKVFVG+FKSRKERE
Sbjct: 121 AFGNILSCKVVCDENGSKGYAFVHFETQEAADKAIEKMNGMLLNDRKVFVGRFKSRKERE 180

Query: 181 AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER 240
           AELGA+AKEF NVYIKNFGE++DDE LK+LF +FG  LSVKVM D +GKSKGFGFVS+E+
Sbjct: 181 AELGAKAKEFTNVYIKNFGEEVDDESLKELFSQFGKTLSVKVMRDPNGKSKGFGFVSYEK 240

Query: 241 HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN 300
           HEDA KAV+EMNGKE++GK I+VGRAQKKVERQ ELKR FEQ+KQ+RI+RYQ VNLY+KN
Sbjct: 241 HEDANKAVEEMNGKEISGKIIFVGRAQKKVERQAELKRKFEQLKQERISRYQGVNLYIKN 300

Query: 301 LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT 360
           LDD IDDE+LRK FSPFG+ITSAKVM+E GRSKGFGFVCFSSPEEATKAVTEMNGRIV +
Sbjct: 301 LDDTIDDEKLRKEFSPFGSITSAKVMLEDGRSKGFGFVCFSSPEEATKAVTEMNGRIVGS 360

Query: 361 KPLYVALAQRKEERQAYLTNEYMQRMASVRAVP-----NQRAPPS-GYFMTAVPQTQNHA 414
           KPLYVALAQRKEER+A+LTN+YMQR+A +RA+P     NQ  P + GYF+ AVPQ Q   
Sbjct: 361 KPLYVALAQRKEERKAHLTNQYMQRVAGMRALPANAILNQFQPAAGGYFVPAVPQAQGRP 420

Query: 415 AYYPPSQIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTM-----RPASSQVPR 469
            YY P+Q+A++RP+PRW  QG RP  FQ  PSAIR   PR     +      PAS  +P 
Sbjct: 421 PYYTPNQLAQMRPNPRW-QQGGRPQGFQGMPSAIRQSGPRPTLRHLAPTGNAPASRGLP- 478

Query: 470 VMSTQRVAN------------------------------TSTQTVGPRPAAAAAAAATPA 499
             +TQRV +                              T+ Q + PR A AAAA     
Sbjct: 479 -TTTQRVGSECPDRLAMDFGGAGAAQQGLTDSCQSGGVPTAVQNLAPRAAVAAAAP---- 533

Query: 500 VRTVPRYKYAAGVRNPQQHRNAQPQVTMQQLAVHVQGQETLTASRLASAPPQKQKQMLGE 559
            R V  YKYA+ VR+P  H   QP +   Q AVHVQGQE LTAS LA+APPQ+QKQMLGE
Sbjct: 534 -RAVAPYKYASSVRSP--HPAIQP-LQAPQPAVHVQGQEPLTASMLAAAPPQEQKQMLGE 589

Query: 560 RLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLESPESLRSKVDEAVAVLQAHQA-KEAT 618
           RLFPLIQ MH  LAGKITGMLLEIDNSELL+MLESPESLRSKVDEAVAVLQAH A KEA 
Sbjct: 590 RLFPLIQTMHSNLAGKITGMLLEIDNSELLHMLESPESLRSKVDEAVAVLQAHHAKKEAA 649

Query: 619 QK--AVNSAT 626
           QK  AV +AT
Sbjct: 650 QKVGAVAAAT 659


>gi|185135971 poly(A)-binding protein, cytoplasmic 1-like [Homo
           sapiens]
          Length = 614

 Score =  790 bits (2040), Expect = 0.0
 Identities = 409/621 (65%), Positives = 476/621 (76%), Gaps = 19/621 (3%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           MN S   YP ASLYVGDLHPDVTEAMLYEKFSPAGPILSIR+CRD+ T  S  YAY+NFQ
Sbjct: 1   MNASGSGYPLASLYVGDLHPDVTEAMLYEKFSPAGPILSIRVCRDVATRRSLGYAYINFQ 60

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS 120
              DAE ALDTMNF+++KG+P+RIMWSQRDP LRKSGVGNIF+KNL+ SI+NKALYDT S
Sbjct: 61  QPADAERALDTMNFEMLKGQPIRIMWSQRDPGLRKSGVGNIFIKNLEDSIDNKALYDTFS 120

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180
            FGNILSC V CDE+GS+G+GFVHFETHEAA++AI  MNGMLLN RKVFVG FKSR+ERE
Sbjct: 121 TFGNILSCKVACDEHGSRGFGFVHFETHEAAQQAINTMNGMLLNDRKVFVGHFKSRRERE 180

Query: 181 AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFER 240
           AELGARA EF N+Y+KN   D+D++ L+DLF +FG  LSVKVM D SG S+ FGFV+FE+
Sbjct: 181 AELGARALEFTNIYVKNLPVDVDEQGLQDLFSQFGKMLSVKVMRDNSGHSRCFGFVNFEK 240

Query: 241 HEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKN 300
           HE+AQKAV  MNGKE++G+ +Y GRAQK+VERQ ELKR FEQMKQDR+ RYQ VNLYVKN
Sbjct: 241 HEEAQKAVVHMNGKEVSGRLLYAGRAQKRVERQNELKRRFEQMKQDRLRRYQGVNLYVKN 300

Query: 301 LDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVAT 360
           LDD IDD++LRK FSP+G ITSAKVM EGG SKGFGFVCFSSPEEATKAVTEMNGRIV T
Sbjct: 301 LDDSIDDDKLRKEFSPYGVITSAKVMTEGGHSKGFGFVCFSSPEEATKAVTEMNGRIVGT 360

Query: 361 KPLYVALAQRKEERQAYLTNEYMQRMASVRAVPN----QRAPPSGYFMTAVPQTQNHAAY 416
           KPLYVALAQRKEER+A LTN+YMQR++++R + N        PS YF+ A+PQ    AAY
Sbjct: 361 KPLYVALAQRKEERKAILTNQYMQRLSTMRTLSNPLLGSFQQPSSYFLPAMPQPPAQAAY 420

Query: 417 YPPSQIARLRPSPRWTAQGARPHPFQNKPSAIRPGAPRVPFSTMRPASSQVPR-VMSTQR 475
           Y    +   +P+PRWT+Q  RP         + P  P    S++R AS+QVPR V  TQR
Sbjct: 421 YGCGPVTPTQPAPRWTSQPPRPSCASMVRPPVVPRRPPAHISSVRQASTQVPRTVPHTQR 480

Query: 476 VANTSTQTVGPRPAAAAAAAATPAVRTVPRYKYAAGVRNPQQHRNAQPQVTMQQLAVHVQ 535
           VAN  TQT GP    +     TP    +P    +A          A     +Q+ AVH+ 
Sbjct: 481 VANIGTQTTGP----SGVGCCTPGRPLLPCKCSSA----------AHSTYRVQEPAVHIP 526

Query: 536 GQETLTASRLASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLESP 595
           GQE LTAS LA+AP  +QKQM+GERL+PLI  +H  LAGKITGMLLEIDNSELL MLESP
Sbjct: 527 GQEPLTASMLAAAPLHEQKQMIGERLYPLIHDVHTQLAGKITGMLLEIDNSELLLMLESP 586

Query: 596 ESLRSKVDEAVAVLQAHQAKE 616
           ESL +K+DEAVAVLQAHQA E
Sbjct: 587 ESLHAKIDEAVAVLQAHQAME 607


>gi|168229150 poly(A) binding protein, cytoplasmic 4-like [Homo
           sapiens]
          Length = 370

 Score =  511 bits (1315), Expect = e-144
 Identities = 249/363 (68%), Positives = 299/363 (82%)

Query: 8   YPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEH 67
           Y  ASLYVGDLH DVTE +L+ KFS  GP+LSIRICRD +T  S  YAYVNF    DA+ 
Sbjct: 7   YRMASLYVGDLHADVTEDLLFRKFSTVGPVLSIRICRDQVTRRSLGYAYVNFLQLADAQK 66

Query: 68  ALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILS 127
           ALDTMNFD+IKGK +R+MWSQRD  LR+SG+GN+F+KNLDKSI+NK LY+  SAFG ILS
Sbjct: 67  ALDTMNFDIIKGKSIRLMWSQRDAYLRRSGIGNVFIKNLDKSIDNKTLYEHFSAFGKILS 126

Query: 128 CNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARA 187
             V+ D+ GSKGY FVHF+   AA+RAI++MNG LL G KVFVG+FK+RK+REAEL ++A
Sbjct: 127 SKVMSDDQGSKGYAFVHFQNQSAADRAIEEMNGKLLKGCKVFVGRFKNRKDREAELRSKA 186

Query: 188 KEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKA 247
            EF NVYIKNFG DMDDERLKD+F K+G  LSVKVMTD SGKSKGFGFVSF+ HE A+KA
Sbjct: 187 SEFTNVYIKNFGGDMDDERLKDVFSKYGKTLSVKVMTDSSGKSKGFGFVSFDSHEAAKKA 246

Query: 248 VDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDD 307
           V+EMNG+++NG+ I+VGRAQKKVERQ ELK+ FEQ+K++RI   Q V LY+KNLDD IDD
Sbjct: 247 VEEMNGRDINGQLIFVGRAQKKVERQAELKQMFEQLKRERIRGCQGVKLYIKNLDDTIDD 306

Query: 308 ERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVAL 367
           E+LR  FS FG+I+  KVM E G+SKGFG +CFSSPE+ATKA+TEMNGRI+ +KPL +AL
Sbjct: 307 EKLRNEFSSFGSISRVKVMQEEGQSKGFGLICFSSPEDATKAMTEMNGRILGSKPLSIAL 366

Query: 368 AQR 370
           AQR
Sbjct: 367 AQR 369



 Score =  174 bits (442), Expect = 2e-43
 Identities = 107/293 (36%), Positives = 164/293 (55%), Gaps = 20/293 (6%)

Query: 95  KSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAE 152
           K  + +++V +L   +    L+   S  G +LS  +  D+    S GY +V+F     A+
Sbjct: 6   KYRMASLYVGDLHADVTEDLLFRKFSTVGPVLSIRICRDQVTRRSLGYAYVNFLQLADAQ 65

Query: 153 RAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFG 212
           +A+  MN  ++ G+ + +       +R+A L  R     NV+IKN  + +D++ L + F 
Sbjct: 66  KALDTMNFDIIKGKSIRL----MWSQRDAYL--RRSGIGNVFIKNLDKSIDNKTLYEHFS 119

Query: 213 KFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVER 272
            FG  LS KVM+D+ G SKG+ FV F+    A +A++EMNGK L G +++VGR + + +R
Sbjct: 120 AFGKILSSKVMSDDQG-SKGYAFVHFQNQSAADRAIEEMNGKLLKGCKVFVGRFKNRKDR 178

Query: 273 QTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEG-GR 331
           + EL+    +            N+Y+KN    +DDERL+  FS +G   S KVM +  G+
Sbjct: 179 EAELRSKASEF----------TNVYIKNFGGDMDDERLKDVFSKYGKTLSVKVMTDSSGK 228

Query: 332 SKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAYLTNEYMQ 384
           SKGFGFV F S E A KAV EMNGR +  + ++V  AQ+K ERQA L   + Q
Sbjct: 229 SKGFGFVSFDSHEAAKKAVEEMNGRDINGQLIFVGRAQKKVERQAELKQMFEQ 281


>gi|18201888 poly(A) binding protein, cytoplasmic 5 [Homo sapiens]
          Length = 382

 Score =  451 bits (1161), Expect = e-127
 Identities = 226/365 (61%), Positives = 284/365 (77%), Gaps = 1/365 (0%)

Query: 8   YPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEH 67
           Y  A+LYVGDL PDVTE MLY+KF PAGP+   RICRD +T     Y YVNF+   DAE 
Sbjct: 15  YLKAALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEW 74

Query: 68  ALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILS 127
           AL+TMNFD+I GKP R+MWSQ D  LRKSGVGNIF+KNLDKSI+N+AL+   SAFGNILS
Sbjct: 75  ALNTMNFDLINGKPFRLMWSQPDDRLRKSGVGNIFIKNLDKSIDNRALFYLFSAFGNILS 134

Query: 128 CNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARA 187
           C VVCD+NGSKGY +VHF++  AA RAI  MNG+ LN R+V+VG+FK  +ER AE+  R 
Sbjct: 135 CKVVCDDNGSKGYAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRTRD 194

Query: 188 K-EFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQK 246
           +  F NV++KN G+D+DDE+LK+LF ++GP  SVKV+ D SGKSKGFGFV +E HE AQK
Sbjct: 195 RATFTNVFVKNIGDDIDDEKLKELFCEYGPTESVKVIRDASGKSKGFGFVRYETHEAAQK 254

Query: 247 AVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGID 306
           AV +++GK ++GK +YVGRAQKK+ER  EL+R FE+++    +R   V +Y+KNLD+ I+
Sbjct: 255 AVLDLHGKSIDGKVLYVGRAQKKIERLAELRRRFERLRLKEKSRPPGVPIYIKNLDETIN 314

Query: 307 DERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVA 366
           DE+L++ FS FG+I+ AKVMME G+ KGFG VCFSS EEATKAV EMNGRIV +KPL+V 
Sbjct: 315 DEKLKEEFSSFGSISRAKVMMEVGQGKGFGVVCFSSFEEATKAVDEMNGRIVGSKPLHVT 374

Query: 367 LAQRK 371
           L Q +
Sbjct: 375 LGQAR 379



 Score =  157 bits (398), Expect = 2e-38
 Identities = 109/315 (34%), Positives = 165/315 (52%), Gaps = 23/315 (7%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAIKKM 158
           ++V +LD  +    LY      G +    +  D       GYG+V+F     AE A+  M
Sbjct: 20  LYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAEWALNTM 79

Query: 159 NGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPAL 218
           N  L+NG K F   +    +R  + G       N++IKN  + +D+  L  LF  FG  L
Sbjct: 80  NFDLING-KPFRLMWSQPDDRLRKSGVG-----NIFIKNLDKSIDNRALFYLFSAFGNIL 133

Query: 219 SVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKR 278
           S KV+ D++G SKG+ +V F+    A +A+  MNG  LN +Q+YVGR +   ER  E++ 
Sbjct: 134 SCKVVCDDNG-SKGYAYVHFDSLAAANRAIWHMNGVRLNNRQVYVGRFKFPEERAAEVRT 192

Query: 279 TFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEG-GRSKGFGF 337
                 +DR T     N++VKN+ D IDDE+L++ F  +G   S KV+ +  G+SKGFGF
Sbjct: 193 ------RDRAT---FTNVFVKNIGDDIDDEKLKELFCEYGPTESVKVIRDASGKSKGFGF 243

Query: 338 VCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAYLTNEYMQRMASVRAVPNQRA 397
           V + + E A KAV +++G+ +  K LYV  AQ+K ER A    E  +R   +R     R 
Sbjct: 244 VRYETHEAAQKAVLDLHGKSIDGKVLYVGRAQKKIERLA----ELRRRFERLRLKEKSRP 299

Query: 398 PPSGYFMTAVPQTQN 412
           P    ++  + +T N
Sbjct: 300 PGVPIYIKNLDETIN 314



 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 49/184 (26%), Positives = 94/184 (51%), Gaps = 21/184 (11%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +++V ++  D+ +  L E F   GP  S+++ RD  +  S  + +V ++  + A+ A+  
Sbjct: 200 NVFVKNIGDDIDDEKLKELFCEYGPTESVKVIRDA-SGKSKGFGFVRYETHEAAQKAVLD 258

Query: 72  MNFDVIKGKPVRIMWSQRD-----------------PSLRKSGVGNIFVKNLDKSINNKA 114
           ++   I GK + +  +Q+                     R  GV  I++KNLD++IN++ 
Sbjct: 259 LHGKSIDGKVLYVGRAQKKIERLAELRRRFERLRLKEKSRPPGVP-IYIKNLDETINDEK 317

Query: 115 LYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFV--GQ 172
           L +  S+FG+I    V+ +    KG+G V F + E A +A+ +MNG ++  + + V  GQ
Sbjct: 318 LKEEFSSFGSISRAKVMMEVGQGKGFGVVCFSSFEEATKAVDEMNGRIVGSKPLHVTLGQ 377

Query: 173 FKSR 176
            + R
Sbjct: 378 ARRR 381



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 23/82 (28%), Positives = 40/82 (48%), Gaps = 2/82 (2%)

Query: 290 RYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEGGRSK--GFGFVCFSSPEEAT 347
           +Y    LYV +LD  + ++ L K F P G +   ++  +       G+G+V F  P +A 
Sbjct: 14  KYLKAALYVGDLDPDVTEDMLYKKFRPAGPLRFTRICRDPVTRSPLGYGYVNFRFPADAE 73

Query: 348 KAVTEMNGRIVATKPLYVALAQ 369
            A+  MN  ++  KP  +  +Q
Sbjct: 74  WALNTMNFDLINGKPFRLMWSQ 95


>gi|109948285 poly(A) binding protein, cytoplasmic 1-like 2B [Homo
           sapiens]
          Length = 200

 Score =  293 bits (751), Expect = 3e-79
 Identities = 143/195 (73%), Positives = 164/195 (84%)

Query: 11  ASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALD 70
           ASLYVGDLHP+VTEAMLYEKFSPAGPILSIRICRD IT  S  YAYVN+Q   DA+ AL+
Sbjct: 2   ASLYVGDLHPEVTEAMLYEKFSPAGPILSIRICRDKITRRSLGYAYVNYQQPVDAKRALE 61

Query: 71  TMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNV 130
           T+NFDVIKG+PVRIMWSQRDPSLRKSGVGN+F+KNL K+I+NKALY+  SAFGNILSC V
Sbjct: 62  TLNFDVIKGRPVRIMWSQRDPSLRKSGVGNVFIKNLGKTIDNKALYNIFSAFGNILSCKV 121

Query: 131 VCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEF 190
            CDE G KGYGFVHF+  E+AERAI  MNGM LN RK+FVG+FKS KEREAE GA A++ 
Sbjct: 122 ACDEKGPKGYGFVHFQKQESAERAIDVMNGMFLNYRKIFVGRFKSHKEREAERGAWARQS 181

Query: 191 PNVYIKNFGEDMDDE 205
            +  +K+F ED D+E
Sbjct: 182 TSADVKDFEEDTDEE 196



 Score =  107 bits (266), Expect = 4e-23
 Identities = 64/180 (35%), Positives = 104/180 (57%), Gaps = 9/180 (5%)

Query: 98  VGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAI 155
           + +++V +L   +    LY+  S  G ILS  +  D+    S GY +V+++    A+RA+
Sbjct: 1   MASLYVGDLHPEVTEAMLYEKFSPAGPILSIRICRDKITRRSLGYAYVNYQQPVDAKRAL 60

Query: 156 KKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFG 215
           + +N  ++ GR V +       +R+  L  R     NV+IKN G+ +D++ L ++F  FG
Sbjct: 61  ETLNFDVIKGRPVRI----MWSQRDPSL--RKSGVGNVFIKNLGKTIDNKALYNIFSAFG 114

Query: 216 PALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTE 275
             LS KV  DE G  KG+GFV F++ E A++A+D MNG  LN ++I+VGR +   ER+ E
Sbjct: 115 NILSCKVACDEKGP-KGYGFVHFQKQESAERAIDVMNGMFLNYRKIFVGRFKSHKEREAE 173



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 51/186 (27%), Positives = 100/186 (53%), Gaps = 17/186 (9%)

Query: 192 NVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDE 250
           ++Y+ +   ++ +  L + F   GP LS+++  D+ + +S G+ +V++++  DA++A++ 
Sbjct: 3   SLYVGDLHPEVTEAMLYEKFSPAGPILSIRICRDKITRRSLGYAYVNYQQPVDAKRALET 62

Query: 251 MNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERL 310
           +N   + G+ + +  +Q    R   L+++             V N+++KNL   ID++ L
Sbjct: 63  LNFDVIKGRPVRIMWSQ----RDPSLRKS------------GVGNVFIKNLGKTIDNKAL 106

Query: 311 RKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQR 370
              FS FG I S KV  +    KG+GFV F   E A +A+  MNG  +  + ++V   + 
Sbjct: 107 YNIFSAFGNILSCKVACDEKGPKGYGFVHFQKQESAERAIDVMNGMFLNYRKIFVGRFKS 166

Query: 371 KEERQA 376
            +ER+A
Sbjct: 167 HKEREA 172



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 2/72 (2%)

Query: 2   NPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQH 61
           +PS       ++++ +L   +    LY  FS  G ILS ++  D    G   Y +V+FQ 
Sbjct: 81  DPSLRKSGVGNVFIKNLGKTIDNKALYNIFSAFGNILSCKVACD--EKGPKGYGFVHFQK 138

Query: 62  TKDAEHALDTMN 73
            + AE A+D MN
Sbjct: 139 QESAERAIDVMN 150



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 22/80 (27%), Positives = 44/80 (55%), Gaps = 2/80 (2%)

Query: 293 VVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAV 350
           + +LYV +L   + +  L + FSP G I S ++  +    RS G+ +V +  P +A +A+
Sbjct: 1   MASLYVGDLHPEVTEAMLYEKFSPAGPILSIRICRDKITRRSLGYAYVNYQQPVDAKRAL 60

Query: 351 TEMNGRIVATKPLYVALAQR 370
             +N  ++  +P+ +  +QR
Sbjct: 61  ETLNFDVIKGRPVRIMWSQR 80


>gi|61175237 poly(A) binding protein, cytoplasmic 1-like 2A [Homo
           sapiens]
          Length = 200

 Score =  293 bits (751), Expect = 3e-79
 Identities = 143/195 (73%), Positives = 164/195 (84%)

Query: 11  ASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALD 70
           ASLYVGDLHP+VTEAMLYEKFSPAGPILSIRICRD IT  S  YAYVN+Q   DA+ AL+
Sbjct: 2   ASLYVGDLHPEVTEAMLYEKFSPAGPILSIRICRDKITRRSLGYAYVNYQQPVDAKRALE 61

Query: 71  TMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNV 130
           T+NFDVIKG+PVRIMWSQRDPSLRKSGVGN+F+KNL K+I+NKALY+  SAFGNILSC V
Sbjct: 62  TLNFDVIKGRPVRIMWSQRDPSLRKSGVGNVFIKNLGKTIDNKALYNIFSAFGNILSCKV 121

Query: 131 VCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEF 190
            CDE G KGYGFVHF+  E+AERAI  MNGM LN RK+FVG+FKS KEREAE GA A++ 
Sbjct: 122 ACDEKGPKGYGFVHFQKQESAERAIDVMNGMFLNYRKIFVGRFKSHKEREAERGAWARQS 181

Query: 191 PNVYIKNFGEDMDDE 205
            +  +K+F ED D+E
Sbjct: 182 TSADVKDFEEDTDEE 196



 Score =  107 bits (266), Expect = 4e-23
 Identities = 64/180 (35%), Positives = 104/180 (57%), Gaps = 9/180 (5%)

Query: 98  VGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAI 155
           + +++V +L   +    LY+  S  G ILS  +  D+    S GY +V+++    A+RA+
Sbjct: 1   MASLYVGDLHPEVTEAMLYEKFSPAGPILSIRICRDKITRRSLGYAYVNYQQPVDAKRAL 60

Query: 156 KKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFG 215
           + +N  ++ GR V +       +R+  L  R     NV+IKN G+ +D++ L ++F  FG
Sbjct: 61  ETLNFDVIKGRPVRI----MWSQRDPSL--RKSGVGNVFIKNLGKTIDNKALYNIFSAFG 114

Query: 216 PALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTE 275
             LS KV  DE G  KG+GFV F++ E A++A+D MNG  LN ++I+VGR +   ER+ E
Sbjct: 115 NILSCKVACDEKGP-KGYGFVHFQKQESAERAIDVMNGMFLNYRKIFVGRFKSHKEREAE 173



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 51/186 (27%), Positives = 100/186 (53%), Gaps = 17/186 (9%)

Query: 192 NVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDE 250
           ++Y+ +   ++ +  L + F   GP LS+++  D+ + +S G+ +V++++  DA++A++ 
Sbjct: 3   SLYVGDLHPEVTEAMLYEKFSPAGPILSIRICRDKITRRSLGYAYVNYQQPVDAKRALET 62

Query: 251 MNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERL 310
           +N   + G+ + +  +Q    R   L+++             V N+++KNL   ID++ L
Sbjct: 63  LNFDVIKGRPVRIMWSQ----RDPSLRKS------------GVGNVFIKNLGKTIDNKAL 106

Query: 311 RKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQR 370
              FS FG I S KV  +    KG+GFV F   E A +A+  MNG  +  + ++V   + 
Sbjct: 107 YNIFSAFGNILSCKVACDEKGPKGYGFVHFQKQESAERAIDVMNGMFLNYRKIFVGRFKS 166

Query: 371 KEERQA 376
            +ER+A
Sbjct: 167 HKEREA 172



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 23/72 (31%), Positives = 36/72 (50%), Gaps = 2/72 (2%)

Query: 2   NPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQH 61
           +PS       ++++ +L   +    LY  FS  G ILS ++  D    G   Y +V+FQ 
Sbjct: 81  DPSLRKSGVGNVFIKNLGKTIDNKALYNIFSAFGNILSCKVACD--EKGPKGYGFVHFQK 138

Query: 62  TKDAEHALDTMN 73
            + AE A+D MN
Sbjct: 139 QESAERAIDVMN 150



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 22/80 (27%), Positives = 44/80 (55%), Gaps = 2/80 (2%)

Query: 293 VVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAV 350
           + +LYV +L   + +  L + FSP G I S ++  +    RS G+ +V +  P +A +A+
Sbjct: 1   MASLYVGDLHPEVTEAMLYEKFSPAGPILSIRICRDKITRRSLGYAYVNYQQPVDAKRAL 60

Query: 351 TEMNGRIVATKPLYVALAQR 370
             +N  ++  +P+ +  +QR
Sbjct: 61  ETLNFDVIKGRPVRIMWSQR 80


>gi|239753150 PREDICTED: similar to poly(A) binding protein,
           cytoplasmic 1 [Homo sapiens]
          Length = 94

 Score =  140 bits (353), Expect = 4e-33
 Identities = 73/84 (86%), Positives = 78/84 (92%)

Query: 545 LASAPPQKQKQMLGERLFPLIQAMHPTLAGKITGMLLEIDNSELLYMLESPESLRSKVDE 604
           LASAPPQ+QK++LGERLFPLIQAMHPTLAGKITGM LE DNSELL+MLESPESL SKV E
Sbjct: 2   LASAPPQEQKRILGERLFPLIQAMHPTLAGKITGMWLETDNSELLHMLESPESLHSKVVE 61

Query: 605 AVAVLQAHQAKEATQKAVNSATGV 628
           AVAVLQAH+AKEA QKAVNSAT V
Sbjct: 62  AVAVLQAHRAKEAAQKAVNSATAV 85


>gi|188219591 TIA1 protein isoform 2 [Homo sapiens]
          Length = 386

 Score =  120 bits (300), Expect = 5e-27
 Identities = 74/270 (27%), Positives = 132/270 (48%), Gaps = 16/270 (5%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNG 160
           ++V NL + +    +    S  G   +C ++ D  G+  Y FV F  H  A  A+  MNG
Sbjct: 9   LYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNG 68

Query: 161 MLLNGRKVFVGQFKSRKEREAELGA-------RAKEFPNVYIKNFGEDMDDERLKDLFGK 213
             + G++V V    +   ++ +  +       R+++  +V++ +   ++  E +K  F  
Sbjct: 69  RKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAAFAP 128

Query: 214 FGPALSVKVMTD-ESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVER 272
           FG     +V+ D  +GKSKG+GFVSF    DA+ A+ +M G+ L G+QI    A +K   
Sbjct: 129 FGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPA 188

Query: 273 -QTELKRTFEQMKQDRITRYQV---VNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMME 328
            ++  +   +Q+  D +          +Y   +  G+ ++ +R+ FSPFG I   +V  +
Sbjct: 189 PKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPD 248

Query: 329 GGRSKGFGFVCFSSPEEATKAVTEMNGRIV 358
               KG+ FV F+S E A  A+  +NG  +
Sbjct: 249 ----KGYSFVRFNSHESAAHAIVSVNGTTI 274



 Score =  108 bits (271), Expect = 1e-23
 Identities = 79/276 (28%), Positives = 124/276 (44%), Gaps = 36/276 (13%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +LYVG+L  DVTEA++ + FS  GP  + ++  D  T+G+  Y +V F   + A  AL  
Sbjct: 8   TLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMD--TAGNDPYCFVEFHEHRHAAAALAA 65

Query: 72  MNFDVIKGKPVRIMWSQRDPSLRKSGVG-------------NIFVKNLDKSINNKALYDT 118
           MN   I GK V++ W+    S +K                 ++FV +L   I  + +   
Sbjct: 66  MNGRKIMGKEVKVNWATTPSSQKKDTSSSTVVSTQRSQDHFHVFVGDLSPEITTEDIKAA 125

Query: 119 VSAFGNILSCNVVCD--ENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFV------ 170
            + FG I    VV D     SKGYGFV F     AE AI++M G  L GR++        
Sbjct: 126 FAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRK 185

Query: 171 -----GQFKSRKER---EAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKV 222
                  ++S  ++   +  +   +     VY       + ++ ++  F  FG  + ++V
Sbjct: 186 PPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRV 245

Query: 223 MTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNG 258
             D     KG+ FV F  HE A  A+  +NG  + G
Sbjct: 246 FPD-----KGYSFVRFNSHESAAHAIVSVNGTTIEG 276



 Score = 92.4 bits (228), Expect = 1e-18
 Identities = 71/249 (28%), Positives = 118/249 (47%), Gaps = 22/249 (8%)

Query: 193 VYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMN 252
           +Y+ N   D+ +  +  LF + GP  + K++ D +G    + FV F  H  A  A+  MN
Sbjct: 9   LYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDP-YCFVEFHEHRHAAAALAAMN 67

Query: 253 GKELNGKQIYVGRA-----QKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDD 307
           G+++ GK++ V  A     QKK    + +  T  Q  QD        +++V +L   I  
Sbjct: 68  GRKIMGKEVKVNWATTPSSQKKDTSSSTVVST--QRSQDHF------HVFVGDLSPEITT 119

Query: 308 ERLRKAFSPFGTITSAKVM--MEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYV 365
           E ++ AF+PFG I+ A+V+  M  G+SKG+GFV F +  +A  A+ +M G+ +  + +  
Sbjct: 120 EDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRT 179

Query: 366 ALAQRKEERQAYLTNEYMQRMASVRAVPNQRAPPS-----GYFMTAVPQTQNHAAYYPPS 420
             A RK       T E   +  S   V NQ +P +     G   + + +      + P  
Sbjct: 180 NWATRKPPAPK-STYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFG 238

Query: 421 QIARLRPSP 429
           QI  +R  P
Sbjct: 239 QIMEIRVFP 247



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 51/176 (28%), Positives = 81/176 (46%), Gaps = 24/176 (13%)

Query: 13  LYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDTM 72
           ++VGDL P++T   +   F+P G I   R+ +D+ T  S  Y +V+F +  DAE+A+  M
Sbjct: 108 VFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQM 167

Query: 73  NFDVIKGKPVRIMWSQRDPSLRKSGVGN--------------------IFVKNLDKSINN 112
               + G+ +R  W+ R P   KS   +                    ++   +   +  
Sbjct: 168 GGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTE 227

Query: 113 KALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKV 168
           + +  T S FG I+   V  D    KGY FV F +HE+A  AI  +NG  + G  V
Sbjct: 228 QLMRQTFSPFGQIMEIRVFPD----KGYSFVRFNSHESAAHAIVSVNGTTIEGHVV 279



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 8/88 (9%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           +N S+PS    ++Y G +   +TE ++ + FSP G I+ IR+  D        Y++V F 
Sbjct: 206 VNQSSPS--NCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPD------KGYSFVRFN 257

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQ 88
             + A HA+ ++N   I+G  V+  W +
Sbjct: 258 SHESAAHAIVSVNGTTIEGHVVKCYWGK 285


>gi|4507499 TIA-1 related protein isoform 1 [Homo sapiens]
          Length = 375

 Score =  119 bits (298), Expect = 8e-27
 Identities = 76/263 (28%), Positives = 127/263 (48%), Gaps = 13/263 (4%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNG 160
           ++V NL + +    +    S  G   SC ++ +   +  Y FV F  H  A  A+  MNG
Sbjct: 11  LYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNG 70

Query: 161 MLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSV 220
             + G++V V    +   ++ +         +V++ +   ++  E +K  F  FG     
Sbjct: 71  RKILGKEVKVNWATTPSSQKKDTSNHF----HVFVGDLSPEITTEDIKSAFAPFGKISDA 126

Query: 221 KVMTD-ESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKK--VERQTELK 277
           +V+ D  +GKSKG+GFVSF    DA+ A+  M G+ L G+QI    A +K    + T+  
Sbjct: 127 RVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQEN 186

Query: 278 RTFEQMKQDRITRYQVVN--LYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGF 335
            T +   +D + +    N  +Y   +  G+ D+ +R+ FSPFG I   +V  E    KG+
Sbjct: 187 NTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPE----KGY 242

Query: 336 GFVCFSSPEEATKAVTEMNGRIV 358
            FV FS+ E A  A+  +NG  +
Sbjct: 243 SFVRFSTHESAAHAIVSVNGTTI 265



 Score =  114 bits (284), Expect = 4e-25
 Identities = 86/268 (32%), Positives = 123/268 (45%), Gaps = 31/268 (11%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSN--YAYVNFQHTKDAEHAL 69
           +LYVG+L  DVTE ++ + FS  GP  S +    +IT  +SN  Y +V F   +DA  AL
Sbjct: 10  TLYVGNLSRDVTEVLILQLFSQIGPCKSCK----MITEHTSNDPYCFVEFYEHRDAAAAL 65

Query: 70  DTMNFDVIKGKPVRIMWSQRDPSLRKSGVGN---IFVKNLDKSINNKALYDTVSAFGNIL 126
             MN   I GK V++ W+   PS +K    N   +FV +L   I  + +    + FG I 
Sbjct: 66  AAMNGRKILGKEVKVNWA-TTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKIS 124

Query: 127 SCNVVCD--ENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQF-------KSRK 177
              VV D     SKGYGFV F     AE AI  M G  L GR++            KS +
Sbjct: 125 DARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQ 184

Query: 178 ER-------EAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKS 230
           E        E  +   + +   VY       + D+ ++  F  FG  + ++V  +     
Sbjct: 185 ENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPE----- 239

Query: 231 KGFGFVSFERHEDAQKAVDEMNGKELNG 258
           KG+ FV F  HE A  A+  +NG  + G
Sbjct: 240 KGYSFVRFSTHESAAHAIVSVNGTTIEG 267



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 68/244 (27%), Positives = 111/244 (45%), Gaps = 23/244 (9%)

Query: 193 VYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMN 252
           +Y+ N   D+ +  +  LF + GP  S K++T+ +     + FV F  H DA  A+  MN
Sbjct: 11  LYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDP-YCFVEFYEHRDAAAALAAMN 69

Query: 253 GKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRK 312
           G+++ GK++ V  A            T    K+D    + V   +V +L   I  E ++ 
Sbjct: 70  GRKILGKEVKVNWAT-----------TPSSQKKDTSNHFHV---FVGDLSPEITTEDIKS 115

Query: 313 AFSPFGTITSAKVM--MEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQR 370
           AF+PFG I+ A+V+  M  G+SKG+GFV F +  +A  A+  M G+ +  + +    A R
Sbjct: 116 AFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATR 175

Query: 371 KEERQAYLTNEYMQRMASVRAVPNQRAPPS-----GYFMTAVPQTQNHAAYYPPSQIARL 425
           K       T E   +      V NQ +P +     G   + +        + P  QI  +
Sbjct: 176 KPPAPK-STQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEI 234

Query: 426 RPSP 429
           R  P
Sbjct: 235 RVFP 238



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 55/189 (29%), Positives = 88/189 (46%), Gaps = 27/189 (14%)

Query: 3   PSTPSYPTAS---LYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNF 59
           PS+    T++   ++VGDL P++T   +   F+P G I   R+ +D+ T  S  Y +V+F
Sbjct: 86  PSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSF 145

Query: 60  QHTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGN------------------- 100
            +  DAE+A+  M    + G+ +R  W+ R P   KS   N                   
Sbjct: 146 YNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNC 205

Query: 101 -IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMN 159
            ++   +   + ++ +  T S FG I+   V  +    KGY FV F THE+A  AI  +N
Sbjct: 206 TVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPE----KGYSFVRFSTHESAAHAIVSVN 261

Query: 160 GMLLNGRKV 168
           G  + G  V
Sbjct: 262 GTTIEGHVV 270



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 26/96 (27%), Positives = 50/96 (52%), Gaps = 8/96 (8%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           +N S+P     ++Y G +   +T+ ++ + FSP G I+ IR+  +        Y++V F 
Sbjct: 197 VNQSSPK--NCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPE------KGYSFVRFS 248

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKS 96
             + A HA+ ++N   I+G  V+  W +  P + K+
Sbjct: 249 THESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKN 284


>gi|188219593 TIA1 protein isoform 1 [Homo sapiens]
          Length = 375

 Score =  117 bits (294), Expect = 2e-26
 Identities = 73/263 (27%), Positives = 127/263 (48%), Gaps = 13/263 (4%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNG 160
           ++V NL + +    +    S  G   +C ++ D  G+  Y FV F  H  A  A+  MNG
Sbjct: 9   LYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDPYCFVEFHEHRHAAAALAAMNG 68

Query: 161 MLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSV 220
             + G++V V    +   ++ +         +V++ +   ++  E +K  F  FG     
Sbjct: 69  RKIMGKEVKVNWATTPSSQKKDTSNHF----HVFVGDLSPEITTEDIKAAFAPFGRISDA 124

Query: 221 KVMTD-ESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVER-QTELKR 278
           +V+ D  +GKSKG+GFVSF    DA+ A+ +M G+ L G+QI    A +K    ++  + 
Sbjct: 125 RVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYES 184

Query: 279 TFEQMKQDRITRYQV---VNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEGGRSKGF 335
             +Q+  D +          +Y   +  G+ ++ +R+ FSPFG I   +V  +    KG+
Sbjct: 185 NTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPD----KGY 240

Query: 336 GFVCFSSPEEATKAVTEMNGRIV 358
            FV F+S E A  A+  +NG  +
Sbjct: 241 SFVRFNSHESAAHAIVSVNGTTI 263



 Score =  114 bits (285), Expect = 3e-25
 Identities = 81/266 (30%), Positives = 125/266 (46%), Gaps = 27/266 (10%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +LYVG+L  DVTEA++ + FS  GP  + ++  D  T+G+  Y +V F   + A  AL  
Sbjct: 8   TLYVGNLSRDVTEALILQLFSQIGPCKNCKMIMD--TAGNDPYCFVEFHEHRHAAAALAA 65

Query: 72  MNFDVIKGKPVRIMWSQRDPSLRKSGVGN---IFVKNLDKSINNKALYDTVSAFGNILSC 128
           MN   I GK V++ W+   PS +K    N   +FV +L   I  + +    + FG I   
Sbjct: 66  MNGRKIMGKEVKVNWA-TTPSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDA 124

Query: 129 NVVCD--ENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFV-----------GQFKS 175
            VV D     SKGYGFV F     AE AI++M G  L GR++               ++S
Sbjct: 125 RVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYES 184

Query: 176 RKER---EAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKG 232
             ++   +  +   +     VY       + ++ ++  F  FG  + ++V  D     KG
Sbjct: 185 NTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPD-----KG 239

Query: 233 FGFVSFERHEDAQKAVDEMNGKELNG 258
           + FV F  HE A  A+  +NG  + G
Sbjct: 240 YSFVRFNSHESAAHAIVSVNGTTIEG 265



 Score = 90.9 bits (224), Expect = 3e-18
 Identities = 68/244 (27%), Positives = 113/244 (46%), Gaps = 23/244 (9%)

Query: 193 VYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMN 252
           +Y+ N   D+ +  +  LF + GP  + K++ D +G    + FV F  H  A  A+  MN
Sbjct: 9   LYVGNLSRDVTEALILQLFSQIGPCKNCKMIMDTAGNDP-YCFVEFHEHRHAAAALAAMN 67

Query: 253 GKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRK 312
           G+++ GK++ V  A            T    K+D    + V   +V +L   I  E ++ 
Sbjct: 68  GRKIMGKEVKVNWAT-----------TPSSQKKDTSNHFHV---FVGDLSPEITTEDIKA 113

Query: 313 AFSPFGTITSAKVM--MEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQR 370
           AF+PFG I+ A+V+  M  G+SKG+GFV F +  +A  A+ +M G+ +  + +    A R
Sbjct: 114 AFAPFGRISDARVVKDMATGKSKGYGFVSFFNKWDAENAIQQMGGQWLGGRQIRTNWATR 173

Query: 371 KEERQAYLTNEYMQRMASVRAVPNQRAPPS-----GYFMTAVPQTQNHAAYYPPSQIARL 425
           K       T E   +  S   V NQ +P +     G   + + +      + P  QI  +
Sbjct: 174 KPPAPK-STYESNTKQLSYDEVVNQSSPSNCTVYCGGVTSGLTEQLMRQTFSPFGQIMEI 232

Query: 426 RPSP 429
           R  P
Sbjct: 233 RVFP 236



 Score = 86.3 bits (212), Expect = 8e-17
 Identities = 54/189 (28%), Positives = 87/189 (46%), Gaps = 27/189 (14%)

Query: 3   PSTPSYPTAS---LYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNF 59
           PS+    T++   ++VGDL P++T   +   F+P G I   R+ +D+ T  S  Y +V+F
Sbjct: 84  PSSQKKDTSNHFHVFVGDLSPEITTEDIKAAFAPFGRISDARVVKDMATGKSKGYGFVSF 143

Query: 60  QHTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGN------------------- 100
            +  DAE+A+  M    + G+ +R  W+ R P   KS   +                   
Sbjct: 144 FNKWDAENAIQQMGGQWLGGRQIRTNWATRKPPAPKSTYESNTKQLSYDEVVNQSSPSNC 203

Query: 101 -IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMN 159
            ++   +   +  + +  T S FG I+   V  D    KGY FV F +HE+A  AI  +N
Sbjct: 204 TVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPD----KGYSFVRFNSHESAAHAIVSVN 259

Query: 160 GMLLNGRKV 168
           G  + G  V
Sbjct: 260 GTTIEGHVV 268



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 27/88 (30%), Positives = 47/88 (53%), Gaps = 8/88 (9%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           +N S+PS    ++Y G +   +TE ++ + FSP G I+ IR+  D        Y++V F 
Sbjct: 195 VNQSSPS--NCTVYCGGVTSGLTEQLMRQTFSPFGQIMEIRVFPD------KGYSFVRFN 246

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQ 88
             + A HA+ ++N   I+G  V+  W +
Sbjct: 247 SHESAAHAIVSVNGTTIEGHVVKCYWGK 274


>gi|5032069 splicing factor 3b, subunit 4 [Homo sapiens]
          Length = 424

 Score =  114 bits (285), Expect = 3e-25
 Identities = 67/183 (36%), Positives = 104/183 (56%), Gaps = 7/183 (3%)

Query: 11  ASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALD 70
           A++YVG L   V+E +L+E F  AGP+++  + +D +T     Y +V F   +DA++A+ 
Sbjct: 13  ATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIK 72

Query: 71  TMNFDVIKGKPVRIMWSQRDPSLRKSGVG-NIFVKNLDKSINNKALYDTVSAFGNILSCN 129
            MN   + GKP+R+  ++     +   VG NIF+ NLD  I+ K LYDT SAFG IL   
Sbjct: 73  IMNMIKLYGKPIRV--NKASAHNKNLDVGANIFIGNLDPEIDEKLLYDTFSAFGVILQTP 130

Query: 130 VVC---DENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGAR 186
            +    D   SKGY F++F + +A++ AI+ MNG  L  R + V  +  +K+ + E    
Sbjct: 131 KIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITV-SYAFKKDSKGERHGS 189

Query: 187 AKE 189
           A E
Sbjct: 190 AAE 192



 Score = 90.1 bits (222), Expect = 5e-18
 Identities = 76/278 (27%), Positives = 126/278 (45%), Gaps = 26/278 (9%)

Query: 193 VYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEM 251
           VY+    E + +  L +LF + GP ++  +  D  +G+ +G+GFV F   EDA  A+  M
Sbjct: 15  VYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSEEDADYAIKIM 74

Query: 252 NGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLR 311
           N  +L GK I V +A     +  ++                  N+++ NLD  ID++ L 
Sbjct: 75  NMIKLYGKPIRVNKASAH-NKNLDVG----------------ANIFIGNLDPEIDEKLLY 117

Query: 312 KAFSPFGTITSAKVMM---EGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALA 368
             FS FG I     +M   + G SKG+ F+ F+S + +  A+  MNG+ +  +P+ V+ A
Sbjct: 118 DTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYA 177

Query: 369 QRKEERQAYLTNEYMQRMASVRAVPNQRAPPSGYFMTAVPQTQNHAAYYPPSQIARLRPS 428
            +K+ +         +R+ + +   +Q   P   F  A P     A     S +    P 
Sbjct: 178 FKKDSK-GERHGSAAERLLAAQNPLSQADRPHQLFADAPPPPS--APNPVVSSLGSGLPP 234

Query: 429 PRWTAQGARPHPFQNKPSAIRPG-APRVPFSTMRPASS 465
           P     G+ P P    P A+ PG  P +P   M P ++
Sbjct: 235 PGMPPPGSFPPPVP-PPGALPPGIPPAMPPPPMPPGAA 271



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 55/183 (30%), Positives = 97/183 (53%), Gaps = 11/183 (6%)

Query: 91  PSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETH 148
           P   ++    ++V  LD+ ++   L++     G +++ ++  D      +GYGFV F + 
Sbjct: 5   PISERNQDATVYVGGLDEKVSEPLLWELFLQAGPVVNTHMPKDRVTGQHQGYGFVEFLSE 64

Query: 149 EAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLK 208
           E A+ AIK MN + L G+ + V +  S   +  ++GA      N++I N   ++D++ L 
Sbjct: 65  EDADYAIKIMNMIKLYGKPIRVNK-ASAHNKNLDVGA------NIFIGNLDPEIDEKLLY 117

Query: 209 DLFGKFGPALSV-KVMTD-ESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRA 266
           D F  FG  L   K+M D ++G SKG+ F++F   + +  A++ MNG+ L  + I V  A
Sbjct: 118 DTFSAFGVILQTPKIMRDPDTGNSKGYAFINFASFDASDAAIEAMNGQYLCNRPITVSYA 177

Query: 267 QKK 269
            KK
Sbjct: 178 FKK 180


>gi|38201714 ELAV-like 1 [Homo sapiens]
          Length = 326

 Score =  112 bits (279), Expect = 1e-24
 Identities = 86/318 (27%), Positives = 147/318 (46%), Gaps = 49/318 (15%)

Query: 97  GVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERA 154
           G  N+ V  L +++    L    S+ G + S  ++ D+    S GYGFV++ T + AERA
Sbjct: 18  GRTNLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERA 77

Query: 155 IKKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKF 214
           I  +NG+ L        Q K+ K   A   +   +  N+YI      M  + ++D+F +F
Sbjct: 78  INTLNGLRL--------QSKTIKVSYARPSSEVIKDANLYISGLPRTMTQKDVEDMFSRF 129

Query: 215 GPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEMNGKELNG--------------- 258
           G  ++ +V+ D+ +G S+G  F+ F++  +A++A+   NG +  G               
Sbjct: 130 GRIINSRVLVDQTTGLSRGVAFIRFDKRSEAEEAITSFNGHKPPGSSEPITVKFAANPNQ 189

Query: 259 -------KQIYVGRAQK---KVERQTELKRTFEQMKQDRITRYQVVN----------LYV 298
                   Q+Y   A++    V  Q +  R F  M  D ++    VN          +++
Sbjct: 190 NKNVALLSQLYHSPARRFGGPVHHQAQRFR-FSPMGVDHMSGLSGVNVPGNASSGWCIFI 248

Query: 299 KNLDDGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMNGR 356
            NL    D+  L + F PFG +T+ KV+ +    + KGFGFV  ++ EEA  A+  +NG 
Sbjct: 249 YNLGQDADEGILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYEEAAMAIASLNGY 308

Query: 357 IVATKPLYVALAQRKEER 374
            +  K L V+    K  +
Sbjct: 309 RLGDKILQVSFKTNKSHK 326



 Score = 79.7 bits (195), Expect = 7e-15
 Identities = 45/151 (29%), Positives = 80/151 (52%), Gaps = 4/151 (2%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +L V  L  ++T+  L   FS  G + S ++ RD +   S  Y +VN+   KDAE A++T
Sbjct: 21  NLIVNYLPQNMTQDELRSLFSSIGEVESAKLIRDKVAGHSLGYGFVNYVTAKDAERAINT 80

Query: 72  MNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVV 131
           +N   ++ K +++ +++  PS       N+++  L +++  K + D  S FG I++  V+
Sbjct: 81  LNGLRLQSKTIKVSYAR--PSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVL 138

Query: 132 CDENG--SKGYGFVHFETHEAAERAIKKMNG 160
            D+    S+G  F+ F+    AE AI   NG
Sbjct: 139 VDQTTGLSRGVAFIRFDKRSEAEEAITSFNG 169



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 57/231 (24%), Positives = 92/231 (39%), Gaps = 55/231 (23%)

Query: 3   PSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHT 62
           PS+     A+LY+  L   +T+  + + FS  G I++ R+  D  T  S   A++ F   
Sbjct: 98  PSSEVIKDANLYISGLPRTMTQKDVEDMFSRFGRIINSRVLVDQTTGLSRGVAFIRFDKR 157

Query: 63  KDAEHALDTMNFDVIKG--KPVRIMWSQRDPSLRK------------------------- 95
            +AE A+ + N     G  +P+ + ++  +P+  K                         
Sbjct: 158 SEAEEAITSFNGHKPPGSSEPITVKFA-ANPNQNKNVALLSQLYHSPARRFGGPVHHQAQ 216

Query: 96  ---------------SGV---GN------IFVKNLDKSINNKALYDTVSAFGNILSCNVV 131
                          SGV   GN      IF+ NL +  +   L+     FG + +  V+
Sbjct: 217 RFRFSPMGVDHMSGLSGVNVPGNASSGWCIFIYNLGQDADEGILWQMFGPFGAVTNVKVI 276

Query: 132 CD--ENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180
            D   N  KG+GFV    +E A  AI  +NG  L G K+    FK+ K  +
Sbjct: 277 RDFNTNKCKGFGFVTMTNYEEAAMAIASLNGYRL-GDKILQVSFKTNKSHK 326


>gi|77695912 TIA-1 related protein isoform 2 [Homo sapiens]
          Length = 392

 Score =  111 bits (277), Expect = 2e-24
 Identities = 79/280 (28%), Positives = 130/280 (46%), Gaps = 30/280 (10%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE------NGSKG-----------YGFV 143
           ++V NL + +    +    S  G   SC ++ ++      N S G           Y FV
Sbjct: 11  LYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFV 70

Query: 144 HFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMD 203
            F  H  A  A+  MNG  + G++V V    +   ++ +         +V++ +   ++ 
Sbjct: 71  EFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHF----HVFVGDLSPEIT 126

Query: 204 DERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIY 262
            E +K  F  FG     +V+ D  +GKSKG+GFVSF    DA+ A+  M G+ L G+QI 
Sbjct: 127 TEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIR 186

Query: 263 VGRAQKK--VERQTELKRTFEQMKQDRITRYQVVN--LYVKNLDDGIDDERLRKAFSPFG 318
              A +K    + T+   T +   +D + +    N  +Y   +  G+ D+ +R+ FSPFG
Sbjct: 187 TNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFG 246

Query: 319 TITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIV 358
            I   +V  E    KG+ FV FS+ E A  A+  +NG  +
Sbjct: 247 QIMEIRVFPE----KGYSFVRFSTHESAAHAIVSVNGTTI 282



 Score =  107 bits (266), Expect = 4e-23
 Identities = 84/281 (29%), Positives = 121/281 (43%), Gaps = 40/281 (14%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSN---------------YAY 56
           +LYVG+L  DVTE ++ + FS  GP  S ++  +   S   N               Y +
Sbjct: 10  TLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCF 69

Query: 57  VNFQHTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGN---IFVKNLDKSINNK 113
           V F   +DA  AL  MN   I GK V++ W+   PS +K    N   +FV +L   I  +
Sbjct: 70  VEFYEHRDAAAALAAMNGRKILGKEVKVNWA-TTPSSQKKDTSNHFHVFVGDLSPEITTE 128

Query: 114 ALYDTVSAFGNILSCNVVCD--ENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVG 171
            +    + FG I    VV D     SKGYGFV F     AE AI  M G  L GR++   
Sbjct: 129 DIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTN 188

Query: 172 QF-------KSRKER-------EAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPA 217
                    KS +E        E  +   + +   VY       + D+ ++  F  FG  
Sbjct: 189 WATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQI 248

Query: 218 LSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNG 258
           + ++V  +     KG+ FV F  HE A  A+  +NG  + G
Sbjct: 249 MEIRVFPE-----KGYSFVRFSTHESAAHAIVSVNGTTIEG 284



 Score = 88.6 bits (218), Expect = 2e-17
 Identities = 55/189 (29%), Positives = 88/189 (46%), Gaps = 27/189 (14%)

Query: 3   PSTPSYPTAS---LYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNF 59
           PS+    T++   ++VGDL P++T   +   F+P G I   R+ +D+ T  S  Y +V+F
Sbjct: 103 PSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSF 162

Query: 60  QHTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGN------------------- 100
            +  DAE+A+  M    + G+ +R  W+ R P   KS   N                   
Sbjct: 163 YNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNC 222

Query: 101 -IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMN 159
            ++   +   + ++ +  T S FG I+   V  +    KGY FV F THE+A  AI  +N
Sbjct: 223 TVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPE----KGYSFVRFSTHESAAHAIVSVN 278

Query: 160 GMLLNGRKV 168
           G  + G  V
Sbjct: 279 GTTIEGHVV 287



 Score = 86.7 bits (213), Expect = 6e-17
 Identities = 71/260 (27%), Positives = 113/260 (43%), Gaps = 38/260 (14%)

Query: 193 VYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDES-----GKSKGFG-----------FV 236
           +Y+ N   D+ +  +  LF + GP  S K++T++        S GF            FV
Sbjct: 11  LYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEQPDSRRVNSSVGFSVLQHTSNDPYCFV 70

Query: 237 SFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNL 296
            F  H DA  A+  MNG+++ GK++ V  A            T    K+D    + V   
Sbjct: 71  EFYEHRDAAAALAAMNGRKILGKEVKVNWAT-----------TPSSQKKDTSNHFHV--- 116

Query: 297 YVKNLDDGIDDERLRKAFSPFGTITSAKVM--MEGGRSKGFGFVCFSSPEEATKAVTEMN 354
           +V +L   I  E ++ AF+PFG I+ A+V+  M  G+SKG+GFV F +  +A  A+  M 
Sbjct: 117 FVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMG 176

Query: 355 GRIVATKPLYVALAQRKEERQAYLTNEYMQRMASVRAVPNQRAPPS-----GYFMTAVPQ 409
           G+ +  + +    A RK       T E   +      V NQ +P +     G   + +  
Sbjct: 177 GQWLGGRQIRTNWATRKPPAPK-STQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTD 235

Query: 410 TQNHAAYYPPSQIARLRPSP 429
                 + P  QI  +R  P
Sbjct: 236 QLMRQTFSPFGQIMEIRVFP 255



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 26/96 (27%), Positives = 50/96 (52%), Gaps = 8/96 (8%)

Query: 1   MNPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQ 60
           +N S+P     ++Y G +   +T+ ++ + FSP G I+ IR+  +        Y++V F 
Sbjct: 214 VNQSSPK--NCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPE------KGYSFVRFS 265

Query: 61  HTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKS 96
             + A HA+ ++N   I+G  V+  W +  P + K+
Sbjct: 266 THESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKN 301


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score =  103 bits (256), Expect = 6e-22
 Identities = 81/314 (25%), Positives = 148/314 (47%), Gaps = 29/314 (9%)

Query: 54  YAYVNFQHTKDAEHALDTMNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNK 113
           + YV+F+  +D E AL+     V  G  +++   +   S ++     +  KNL   +   
Sbjct: 349 FGYVDFESAEDLEKALELTGLKVF-GNEIKLEKPKGKDSKKERDARTLLAKNLPYKVTQD 407

Query: 114 ALYDTVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQF 173
            L +    F +     +V  +  SKG  ++ F+T   AE+  ++  G  ++GR + +   
Sbjct: 408 ELKEV---FEDAAEIRLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYT 464

Query: 174 KSRKEREAELGAR----AKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGK 229
             + + +   G +    + E   + + N      +E L+++F K   A  +KV  +++GK
Sbjct: 465 GEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEVFEK---ATFIKVPQNQNGK 521

Query: 230 SKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRIT 289
           SKG+ F+ F   EDA++A++  N +E+ G+ I   R + +  R +   R+          
Sbjct: 522 SKGYAFIEFASFEDAKEALNSCNKREIEGRAI---RLELQGPRGSPNARSQPSK------ 572

Query: 290 RYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVM-MEGGRSKGFGFVCFSSPEEATK 348
                 L+VK L +   +E L+++F   G++ +  V   E G SKGFGFV F+S E+A  
Sbjct: 573 -----TLFVKGLSEDTTEETLKESFD--GSVRARIVTDRETGSSKGFGFVDFNSEEDAKA 625

Query: 349 AVTEM-NGRIVATK 361
           A   M +G I   K
Sbjct: 626 AKEAMEDGEIDGNK 639



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 75/275 (27%), Positives = 125/275 (45%), Gaps = 33/275 (12%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +L   +L   VT+  L E F  A  I  +   +D     S   AY+ F+   DAE   + 
Sbjct: 394 TLLAKNLPYKVTQDELKEVFEDAAEIRLVS--KD---GKSKGIAYIEFKTEADAEKTFEE 448

Query: 72  MNFDVIKGKPVRIMWS-QRDPSLRKSGVGN---------IFVKNLDKSINNKALYDTVSA 121
                I G+ + + ++ ++  +    G  N         + + NL  S   + L +    
Sbjct: 449 KQGTEIDGRSISLYYTGEKGQNQDYRGGKNSTWSGESKTLVLSNLSYSATEETLQEV--- 505

Query: 122 FGNILSCNVVCDENG-SKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180
           F       V  ++NG SKGY F+ F + E A+ A+   N   + GR +       R E +
Sbjct: 506 FEKATFIKVPQNQNGKSKGYAFIEFASFEDAKEALNSCNKREIEGRAI-------RLELQ 558

Query: 181 AELG---ARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFV 236
              G   AR++    +++K   ED  +E LK+    F  ++  +++TD E+G SKGFGFV
Sbjct: 559 GPRGSPNARSQPSKTLFVKGLSEDTTEETLKE---SFDGSVRARIVTDRETGSSKGFGFV 615

Query: 237 SFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVE 271
            F   EDA+ A + M   E++G ++ +  A+ K E
Sbjct: 616 DFNSEEDAKAAKEAMEDGEIDGNKVTLDWAKPKGE 650



 Score = 76.3 bits (186), Expect = 8e-14
 Identities = 70/276 (25%), Positives = 132/276 (47%), Gaps = 34/276 (12%)

Query: 100 NIFVKNLDKSINNKALYDTVSAFGNILSCN---VVCDENG-SKGYGFVHFETHEAAERAI 155
           N+FV NL+    NK+  +  +   ++ + N   VV    G ++ +G+V FE+ E  E+A+
Sbjct: 308 NLFVGNLNF---NKSAPELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKAL 364

Query: 156 KKMNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFG 215
           +      L G KVF  + K  K +  +   + ++   +  KN    +  + LK++F    
Sbjct: 365 E------LTGLKVFGNEIKLEKPKGKD-SKKERDARTLLAKNLPYKVTQDELKEVFED-- 415

Query: 216 PALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQI---YVGRAQKKVER 272
            A  +++++ + GKSKG  ++ F+   DA+K  +E  G E++G+ I   Y G   +  + 
Sbjct: 416 -AAEIRLVSKD-GKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDY 473

Query: 273 QTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMM-EGGR 331
           +     T+    +          L + NL     +E L++ F      T  KV   + G+
Sbjct: 474 RGGKNSTWSGESK---------TLVLSNLSYSATEETLQEVFEK---ATFIKVPQNQNGK 521

Query: 332 SKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVAL 367
           SKG+ F+ F+S E+A +A+   N R +  + + + L
Sbjct: 522 SKGYAFIEFASFEDAKEALNSCNKREIEGRAIRLEL 557



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 51/234 (21%), Positives = 96/234 (41%), Gaps = 26/234 (11%)

Query: 146 ETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREAEL--GARAKEFPNVYIKNFGEDMD 203
           E  E  E  +K+  G     RK  + + K+  E + +   G       N+++ N   +  
Sbjct: 264 EEEEEEEEPVKEAPGK----RKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKS 319

Query: 204 DERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYV 263
              LK           + V+    G ++ FG+V FE  ED +KA+ E+ G ++ G +I +
Sbjct: 320 APELKTGISDVFAKNDLAVVDVRIGMTRKFGYVDFESAEDLEKAL-ELTGLKVFGNEIKL 378

Query: 264 GRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSA 323
            + + K  ++    RT                L  KNL   +  + L++ F     I   
Sbjct: 379 EKPKGKDSKKERDART----------------LLAKNLPYKVTQDELKEVFEDAAEI--- 419

Query: 324 KVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGRIVATKPLYVALAQRKEERQAY 377
           +++ + G+SKG  ++ F +  +A K   E  G  +  + + +     K + Q Y
Sbjct: 420 RLVSKDGKSKGIAYIEFKTEADAEKTFEEKQGTEIDGRSISLYYTGEKGQNQDY 473



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 27/87 (31%), Positives = 43/87 (49%), Gaps = 3/87 (3%)

Query: 2   NPSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQH 61
           +P+  S P+ +L+V  L  D TE  L E F  +   +  RI  D  T  S  + +V+F  
Sbjct: 563 SPNARSQPSKTLFVKGLSEDTTEETLKESFDGS---VRARIVTDRETGSSKGFGFVDFNS 619

Query: 62  TKDAEHALDTMNFDVIKGKPVRIMWSQ 88
            +DA+ A + M    I G  V + W++
Sbjct: 620 EEDAKAAKEAMEDGEIDGNKVTLDWAK 646


>gi|115511032 ELAV (embryonic lethal, abnormal vision,
           Drosophila)-like 2 (Hu antigen B) [Homo sapiens]
          Length = 359

 Score =  102 bits (253), Expect = 1e-21
 Identities = 80/327 (24%), Positives = 147/327 (44%), Gaps = 60/327 (18%)

Query: 100 NIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAIKK 157
           N+ V  L +++  + L     + G I SC +V D+    S GYGFV++   + AE+AI  
Sbjct: 40  NLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 99

Query: 158 MNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPA 217
           +NG+ L        Q K+ K   A   + +    N+Y+    + M  + L+ LF ++G  
Sbjct: 100 LNGLRL--------QTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRI 151

Query: 218 LSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEMNGKELNG------------------ 258
           ++ +++ D+ +G S+G GF+ F++  +A++A+  +NG++  G                  
Sbjct: 152 ITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVKFANNPSQKTN 211

Query: 259 -----------KQIYVGRAQKKVER--------QTELKRTFEQMKQDRITRYQVVN---- 295
                       + Y G   ++ +R             + F  M  D +T    +N    
Sbjct: 212 QAILSQLYQSPNRRYPGPLAQQAQRFRLDNLLNMAYGVKRFSPMTIDGMTSLAGINIPGH 271

Query: 296 ------LYVKNLDDGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEAT 347
                 ++V NL    D+  L + F PFG +T+ KV+ +    + KGFGFV  ++ +EA 
Sbjct: 272 PGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAA 331

Query: 348 KAVTEMNGRIVATKPLYVALAQRKEER 374
            A+  +NG  +  + L V+    K  +
Sbjct: 332 MAIASLNGYRLGDRVLQVSFKTNKTHK 358



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 63/214 (29%), Positives = 105/214 (49%), Gaps = 33/214 (15%)

Query: 192 NVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDE 250
           N+ +    ++M  E LK LFG  G   S K++ D+ +G+S G+GFV++   +DA+KA++ 
Sbjct: 40  NLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 99

Query: 251 MNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERL 310
           +NG  L  K I V  A+                        +  NLYV  L   +  + L
Sbjct: 100 LNGLRLQTKTIKVSYARPS------------------SASIRDANLYVSGLPKTMTQKEL 141

Query: 311 RKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMNGRIV--ATKPLYVA 366
            + FS +G I +++++++   G S+G GF+ F    EA +A+  +NG+    AT+P+ V 
Sbjct: 142 EQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKRIEAEEAIKGLNGQKPPGATEPITVK 201

Query: 367 LAQRKEER--QAYLTNEYMQRMASVRAVPNQRAP 398
            A    ++  QA L+  Y          PN+R P
Sbjct: 202 FANNPSQKTNQAILSQLYQS--------PNRRYP 227



 Score = 82.0 bits (201), Expect = 1e-15
 Identities = 49/151 (32%), Positives = 82/151 (54%), Gaps = 4/151 (2%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +L V  L  ++T+  L   F   G I S ++ RD IT  S  Y +VN+   KDAE A++T
Sbjct: 40  NLIVNYLPQNMTQEELKSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 99

Query: 72  MNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVV 131
           +N   ++ K +++ +++  PS       N++V  L K++  K L    S +G I++  ++
Sbjct: 100 LNGLRLQTKTIKVSYAR--PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRIL 157

Query: 132 CDE--NGSKGYGFVHFETHEAAERAIKKMNG 160
            D+    S+G GF+ F+    AE AIK +NG
Sbjct: 158 VDQVTGISRGVGFIRFDKRIEAEEAIKGLNG 188



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 64/273 (23%), Positives = 113/273 (41%), Gaps = 34/273 (12%)

Query: 3   PSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHT 62
           PS+ S   A+LYV  L   +T+  L + FS  G I++ RI  D +T  S    ++ F   
Sbjct: 117 PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGISRGVGFIRFDKR 176

Query: 63  KDAEHALDTMNFDVIKG--KPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS 120
            +AE A+  +N     G  +P+ + ++  +PS +        +  L +S N +       
Sbjct: 177 IEAEEAIKGLNGQKPPGATEPITVKFA-NNPSQK---TNQAILSQLYQSPNRRYPGPLAQ 232

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKERE 180
                   N++     +  YG             +K+ + M ++G     G         
Sbjct: 233 QAQRFRLDNLL-----NMAYG-------------VKRFSPMTIDGMTSLAG--------- 265

Query: 181 AELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFVSFE 239
             +         +++ N   D D+  L  +FG FG   +VKV+ D  + K KGFGFV+  
Sbjct: 266 INIPGHPGTGWCIFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMT 325

Query: 240 RHEDAQKAVDEMNGKELNGKQIYVGRAQKKVER 272
            +++A  A+  +NG  L  + + V     K  +
Sbjct: 326 NYDEAAMAIASLNGYRLGDRVLQVSFKTNKTHK 358



 Score = 43.1 bits (100), Expect = 8e-04
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 3/83 (3%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSK--GYGFVHFETHEAAERAIKKM 158
           IFV NL    +   L+     FG + +  V+ D N +K  G+GFV    ++ A  AI  +
Sbjct: 278 IFVYNLAPDADESILWQMFGPFGAVTNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASL 337

Query: 159 NGMLLNGRKVFVGQFKSRKEREA 181
           NG  L G +V    FK+ K  +A
Sbjct: 338 NGYRL-GDRVLQVSFKTNKTHKA 359


>gi|221316773 ELAV-like 4 isoform 5 [Homo sapiens]
          Length = 369

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 77/327 (23%), Positives = 147/327 (44%), Gaps = 60/327 (18%)

Query: 100 NIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAIKK 157
           N+ V  L +++  +       + G I SC +V D+    S GYGFV++   + AE+AI  
Sbjct: 50  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 109

Query: 158 MNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPA 217
           +NG+ L        Q K+ K   A   + +    N+Y+    + M  + L+ LF ++G  
Sbjct: 110 LNGLRL--------QTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRI 161

Query: 218 LSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEMNGKELNG--KQIYVGRAQKKVERQT 274
           ++ +++ D+ +G S+G GF+ F++  +A++A+  +NG++ +G  + I V  A    ++ +
Sbjct: 162 ITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSS 221

Query: 275 EL---------KRTFEQMKQDRITRYQVVNL----------------------------- 296
           +           R +      +  R+++ NL                             
Sbjct: 222 QALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRFSPITIDGMTSLVGMNIPGH 281

Query: 297 -------YVKNLDDGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEAT 347
                  +V NL    D+  L + F PFG + + KV+ +    + KGFGFV  ++ +EA 
Sbjct: 282 TGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAA 341

Query: 348 KAVTEMNGRIVATKPLYVALAQRKEER 374
            A+  +NG  +  + L V+    K  +
Sbjct: 342 MAIASLNGYRLGDRVLQVSFKTNKAHK 368



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 61/214 (28%), Positives = 104/214 (48%), Gaps = 33/214 (15%)

Query: 192 NVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDE 250
           N+ +    ++M  E  + LFG  G   S K++ D+ +G+S G+GFV++   +DA+KA++ 
Sbjct: 50  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 109

Query: 251 MNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERL 310
           +NG  L  K I V  A+                        +  NLYV  L   +  + L
Sbjct: 110 LNGLRLQTKTIKVSYARPS------------------SASIRDANLYVSGLPKTMTQKEL 151

Query: 311 RKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMNGR--IVATKPLYVA 366
            + FS +G I +++++++   G S+G GF+ F    EA +A+  +NG+    AT+P+ V 
Sbjct: 152 EQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVK 211

Query: 367 LAQRKEER--QAYLTNEYMQRMASVRAVPNQRAP 398
            A    ++  QA L+  Y          PN+R P
Sbjct: 212 FANNPSQKSSQALLSQLYQS--------PNRRYP 237



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 49/156 (31%), Positives = 83/156 (53%), Gaps = 4/156 (2%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +L V  L  ++T+      F   G I S ++ RD IT  S  Y +VN+   KDAE A++T
Sbjct: 50  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 109

Query: 72  MNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVV 131
           +N   ++ K +++ +++  PS       N++V  L K++  K L    S +G I++  ++
Sbjct: 110 LNGLRLQTKTIKVSYAR--PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRIL 167

Query: 132 CDE--NGSKGYGFVHFETHEAAERAIKKMNGMLLNG 165
            D+    S+G GF+ F+    AE AIK +NG   +G
Sbjct: 168 VDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSG 203



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 68/276 (24%), Positives = 116/276 (42%), Gaps = 40/276 (14%)

Query: 3   PSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHT 62
           PS+ S   A+LYV  L   +T+  L + FS  G I++ RI  D +T  S    ++ F   
Sbjct: 127 PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKR 186

Query: 63  KDAEHALDTMNFDVIKG--KPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNK---ALYD 117
            +AE A+  +N     G  +P+ + ++  +PS + S      +  L +S N +    L+ 
Sbjct: 187 IEAEEAIKGLNGQKPSGATEPITVKFA-NNPSQKSS---QALLSQLYQSPNRRYPGPLHH 242

Query: 118 TVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRK 177
               F          D   +  YG             +K+ + + ++G    VG      
Sbjct: 243 QAQRFR--------LDNLLNMAYG-------------VKRFSPITIDGMTSLVGM----- 276

Query: 178 EREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFV 236
                +         +++ N   D D+  L  LFG FG   +VKV+ D  + K KGFGFV
Sbjct: 277 ----NIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFV 332

Query: 237 SFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVER 272
           +   +++A  A+  +NG  L  + + V     K  +
Sbjct: 333 TMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHK 368



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 3/83 (3%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSK--GYGFVHFETHEAAERAIKKM 158
           IFV NL    +   L+     FG + +  V+ D N +K  G+GFV    ++ A  AI  +
Sbjct: 288 IFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASL 347

Query: 159 NGMLLNGRKVFVGQFKSRKEREA 181
           NG  L G +V    FK+ K  ++
Sbjct: 348 NGYRL-GDRVLQVSFKTNKAHKS 369


>gi|221316771 ELAV-like 4 isoform 4 [Homo sapiens]
          Length = 366

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 77/327 (23%), Positives = 147/327 (44%), Gaps = 60/327 (18%)

Query: 100 NIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAIKK 157
           N+ V  L +++  +       + G I SC +V D+    S GYGFV++   + AE+AI  
Sbjct: 47  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 106

Query: 158 MNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPA 217
           +NG+ L        Q K+ K   A   + +    N+Y+    + M  + L+ LF ++G  
Sbjct: 107 LNGLRL--------QTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRI 158

Query: 218 LSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEMNGKELNG--KQIYVGRAQKKVERQT 274
           ++ +++ D+ +G S+G GF+ F++  +A++A+  +NG++ +G  + I V  A    ++ +
Sbjct: 159 ITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSS 218

Query: 275 EL---------KRTFEQMKQDRITRYQVVNL----------------------------- 296
           +           R +      +  R+++ NL                             
Sbjct: 219 QALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRFSPITIDGMTSLVGMNIPGH 278

Query: 297 -------YVKNLDDGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEAT 347
                  +V NL    D+  L + F PFG + + KV+ +    + KGFGFV  ++ +EA 
Sbjct: 279 TGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAA 338

Query: 348 KAVTEMNGRIVATKPLYVALAQRKEER 374
            A+  +NG  +  + L V+    K  +
Sbjct: 339 MAIASLNGYRLGDRVLQVSFKTNKAHK 365



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 61/214 (28%), Positives = 104/214 (48%), Gaps = 33/214 (15%)

Query: 192 NVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDE 250
           N+ +    ++M  E  + LFG  G   S K++ D+ +G+S G+GFV++   +DA+KA++ 
Sbjct: 47  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 106

Query: 251 MNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERL 310
           +NG  L  K I V  A+                        +  NLYV  L   +  + L
Sbjct: 107 LNGLRLQTKTIKVSYARPS------------------SASIRDANLYVSGLPKTMTQKEL 148

Query: 311 RKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMNGR--IVATKPLYVA 366
            + FS +G I +++++++   G S+G GF+ F    EA +A+  +NG+    AT+P+ V 
Sbjct: 149 EQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVK 208

Query: 367 LAQRKEER--QAYLTNEYMQRMASVRAVPNQRAP 398
            A    ++  QA L+  Y          PN+R P
Sbjct: 209 FANNPSQKSSQALLSQLYQS--------PNRRYP 234



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 49/156 (31%), Positives = 83/156 (53%), Gaps = 4/156 (2%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +L V  L  ++T+      F   G I S ++ RD IT  S  Y +VN+   KDAE A++T
Sbjct: 47  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 106

Query: 72  MNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVV 131
           +N   ++ K +++ +++  PS       N++V  L K++  K L    S +G I++  ++
Sbjct: 107 LNGLRLQTKTIKVSYAR--PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRIL 164

Query: 132 CDE--NGSKGYGFVHFETHEAAERAIKKMNGMLLNG 165
            D+    S+G GF+ F+    AE AIK +NG   +G
Sbjct: 165 VDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSG 200



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 68/276 (24%), Positives = 116/276 (42%), Gaps = 40/276 (14%)

Query: 3   PSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHT 62
           PS+ S   A+LYV  L   +T+  L + FS  G I++ RI  D +T  S    ++ F   
Sbjct: 124 PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKR 183

Query: 63  KDAEHALDTMNFDVIKG--KPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNK---ALYD 117
            +AE A+  +N     G  +P+ + ++  +PS + S      +  L +S N +    L+ 
Sbjct: 184 IEAEEAIKGLNGQKPSGATEPITVKFA-NNPSQKSS---QALLSQLYQSPNRRYPGPLHH 239

Query: 118 TVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRK 177
               F          D   +  YG             +K+ + + ++G    VG      
Sbjct: 240 QAQRFR--------LDNLLNMAYG-------------VKRFSPITIDGMTSLVGM----- 273

Query: 178 EREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFV 236
                +         +++ N   D D+  L  LFG FG   +VKV+ D  + K KGFGFV
Sbjct: 274 ----NIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFV 329

Query: 237 SFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVER 272
           +   +++A  A+  +NG  L  + + V     K  +
Sbjct: 330 TMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHK 365



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 3/83 (3%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSK--GYGFVHFETHEAAERAIKKM 158
           IFV NL    +   L+     FG + +  V+ D N +K  G+GFV    ++ A  AI  +
Sbjct: 285 IFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASL 344

Query: 159 NGMLLNGRKVFVGQFKSRKEREA 181
           NG  L G +V    FK+ K  ++
Sbjct: 345 NGYRL-GDRVLQVSFKTNKAHKS 366


>gi|221316769 ELAV-like 4 isoform 3 [Homo sapiens]
          Length = 383

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 77/327 (23%), Positives = 147/327 (44%), Gaps = 60/327 (18%)

Query: 100 NIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAIKK 157
           N+ V  L +++  +       + G I SC +V D+    S GYGFV++   + AE+AI  
Sbjct: 64  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 123

Query: 158 MNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPA 217
           +NG+ L        Q K+ K   A   + +    N+Y+    + M  + L+ LF ++G  
Sbjct: 124 LNGLRL--------QTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRI 175

Query: 218 LSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEMNGKELNG--KQIYVGRAQKKVERQT 274
           ++ +++ D+ +G S+G GF+ F++  +A++A+  +NG++ +G  + I V  A    ++ +
Sbjct: 176 ITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSS 235

Query: 275 EL---------KRTFEQMKQDRITRYQVVNL----------------------------- 296
           +           R +      +  R+++ NL                             
Sbjct: 236 QALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRFSPITIDGMTSLVGMNIPGH 295

Query: 297 -------YVKNLDDGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEAT 347
                  +V NL    D+  L + F PFG + + KV+ +    + KGFGFV  ++ +EA 
Sbjct: 296 TGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAA 355

Query: 348 KAVTEMNGRIVATKPLYVALAQRKEER 374
            A+  +NG  +  + L V+    K  +
Sbjct: 356 MAIASLNGYRLGDRVLQVSFKTNKAHK 382



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 61/214 (28%), Positives = 104/214 (48%), Gaps = 33/214 (15%)

Query: 192 NVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDE 250
           N+ +    ++M  E  + LFG  G   S K++ D+ +G+S G+GFV++   +DA+KA++ 
Sbjct: 64  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 123

Query: 251 MNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERL 310
           +NG  L  K I V  A+                        +  NLYV  L   +  + L
Sbjct: 124 LNGLRLQTKTIKVSYARPS------------------SASIRDANLYVSGLPKTMTQKEL 165

Query: 311 RKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMNGR--IVATKPLYVA 366
            + FS +G I +++++++   G S+G GF+ F    EA +A+  +NG+    AT+P+ V 
Sbjct: 166 EQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVK 225

Query: 367 LAQRKEER--QAYLTNEYMQRMASVRAVPNQRAP 398
            A    ++  QA L+  Y          PN+R P
Sbjct: 226 FANNPSQKSSQALLSQLYQS--------PNRRYP 251



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 49/156 (31%), Positives = 83/156 (53%), Gaps = 4/156 (2%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +L V  L  ++T+      F   G I S ++ RD IT  S  Y +VN+   KDAE A++T
Sbjct: 64  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 123

Query: 72  MNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVV 131
           +N   ++ K +++ +++  PS       N++V  L K++  K L    S +G I++  ++
Sbjct: 124 LNGLRLQTKTIKVSYAR--PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRIL 181

Query: 132 CDE--NGSKGYGFVHFETHEAAERAIKKMNGMLLNG 165
            D+    S+G GF+ F+    AE AIK +NG   +G
Sbjct: 182 VDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSG 217



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 68/276 (24%), Positives = 116/276 (42%), Gaps = 40/276 (14%)

Query: 3   PSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHT 62
           PS+ S   A+LYV  L   +T+  L + FS  G I++ RI  D +T  S    ++ F   
Sbjct: 141 PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKR 200

Query: 63  KDAEHALDTMNFDVIKG--KPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNK---ALYD 117
            +AE A+  +N     G  +P+ + ++  +PS + S      +  L +S N +    L+ 
Sbjct: 201 IEAEEAIKGLNGQKPSGATEPITVKFA-NNPSQKSS---QALLSQLYQSPNRRYPGPLHH 256

Query: 118 TVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRK 177
               F          D   +  YG             +K+ + + ++G    VG      
Sbjct: 257 QAQRFR--------LDNLLNMAYG-------------VKRFSPITIDGMTSLVGM----- 290

Query: 178 EREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFV 236
                +         +++ N   D D+  L  LFG FG   +VKV+ D  + K KGFGFV
Sbjct: 291 ----NIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFV 346

Query: 237 SFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVER 272
           +   +++A  A+  +NG  L  + + V     K  +
Sbjct: 347 TMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHK 382



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 3/83 (3%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSK--GYGFVHFETHEAAERAIKKM 158
           IFV NL    +   L+     FG + +  V+ D N +K  G+GFV    ++ A  AI  +
Sbjct: 302 IFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASL 361

Query: 159 NGMLLNGRKVFVGQFKSRKEREA 181
           NG  L G +V    FK+ K  ++
Sbjct: 362 NGYRL-GDRVLQVSFKTNKAHKS 383


>gi|221316767 ELAV-like 4 isoform 2 [Homo sapiens]
          Length = 366

 Score = 98.6 bits (244), Expect = 2e-20
 Identities = 77/327 (23%), Positives = 147/327 (44%), Gaps = 60/327 (18%)

Query: 100 NIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAIKK 157
           N+ V  L +++  +       + G I SC +V D+    S GYGFV++   + AE+AI  
Sbjct: 47  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 106

Query: 158 MNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPA 217
           +NG+ L        Q K+ K   A   + +    N+Y+    + M  + L+ LF ++G  
Sbjct: 107 LNGLRL--------QTKTIKVSYARPSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRI 158

Query: 218 LSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEMNGKELNG--KQIYVGRAQKKVERQT 274
           ++ +++ D+ +G S+G GF+ F++  +A++A+  +NG++ +G  + I V  A    ++ +
Sbjct: 159 ITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVKFANNPSQKSS 218

Query: 275 EL---------KRTFEQMKQDRITRYQVVNL----------------------------- 296
           +           R +      +  R+++ NL                             
Sbjct: 219 QALLSQLYQSPNRRYPGPLHHQAQRFRLDNLLNMAYGVKRFSPITIDGMTSLVGMNIPGH 278

Query: 297 -------YVKNLDDGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEAT 347
                  +V NL    D+  L + F PFG + + KV+ +    + KGFGFV  ++ +EA 
Sbjct: 279 TGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAA 338

Query: 348 KAVTEMNGRIVATKPLYVALAQRKEER 374
            A+  +NG  +  + L V+    K  +
Sbjct: 339 MAIASLNGYRLGDRVLQVSFKTNKAHK 365



 Score = 83.2 bits (204), Expect = 7e-16
 Identities = 61/214 (28%), Positives = 104/214 (48%), Gaps = 33/214 (15%)

Query: 192 NVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDE 250
           N+ +    ++M  E  + LFG  G   S K++ D+ +G+S G+GFV++   +DA+KA++ 
Sbjct: 47  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 106

Query: 251 MNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGIDDERL 310
           +NG  L  K I V  A+                        +  NLYV  L   +  + L
Sbjct: 107 LNGLRLQTKTIKVSYARPS------------------SASIRDANLYVSGLPKTMTQKEL 148

Query: 311 RKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMNGR--IVATKPLYVA 366
            + FS +G I +++++++   G S+G GF+ F    EA +A+  +NG+    AT+P+ V 
Sbjct: 149 EQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSGATEPITVK 208

Query: 367 LAQRKEER--QAYLTNEYMQRMASVRAVPNQRAP 398
            A    ++  QA L+  Y          PN+R P
Sbjct: 209 FANNPSQKSSQALLSQLYQS--------PNRRYP 234



 Score = 81.6 bits (200), Expect = 2e-15
 Identities = 49/156 (31%), Positives = 83/156 (53%), Gaps = 4/156 (2%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +L V  L  ++T+      F   G I S ++ RD IT  S  Y +VN+   KDAE A++T
Sbjct: 47  NLIVNYLPQNMTQEEFRSLFGSIGEIESCKLVRDKITGQSLGYGFVNYIDPKDAEKAINT 106

Query: 72  MNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVV 131
           +N   ++ K +++ +++  PS       N++V  L K++  K L    S +G I++  ++
Sbjct: 107 LNGLRLQTKTIKVSYAR--PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRIL 164

Query: 132 CDE--NGSKGYGFVHFETHEAAERAIKKMNGMLLNG 165
            D+    S+G GF+ F+    AE AIK +NG   +G
Sbjct: 165 VDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPSG 200



 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 68/276 (24%), Positives = 116/276 (42%), Gaps = 40/276 (14%)

Query: 3   PSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHT 62
           PS+ S   A+LYV  L   +T+  L + FS  G I++ RI  D +T  S    ++ F   
Sbjct: 124 PSSASIRDANLYVSGLPKTMTQKELEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKR 183

Query: 63  KDAEHALDTMNFDVIKG--KPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNK---ALYD 117
            +AE A+  +N     G  +P+ + ++  +PS + S      +  L +S N +    L+ 
Sbjct: 184 IEAEEAIKGLNGQKPSGATEPITVKFA-NNPSQKSS---QALLSQLYQSPNRRYPGPLHH 239

Query: 118 TVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRK 177
               F          D   +  YG             +K+ + + ++G    VG      
Sbjct: 240 QAQRFR--------LDNLLNMAYG-------------VKRFSPITIDGMTSLVGM----- 273

Query: 178 EREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFV 236
                +         +++ N   D D+  L  LFG FG   +VKV+ D  + K KGFGFV
Sbjct: 274 ----NIPGHTGTGWCIFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFV 329

Query: 237 SFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVER 272
           +   +++A  A+  +NG  L  + + V     K  +
Sbjct: 330 TMTNYDEAAMAIASLNGYRLGDRVLQVSFKTNKAHK 365



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 27/83 (32%), Positives = 41/83 (49%), Gaps = 3/83 (3%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDENGSK--GYGFVHFETHEAAERAIKKM 158
           IFV NL    +   L+     FG + +  V+ D N +K  G+GFV    ++ A  AI  +
Sbjct: 285 IFVYNLSPDSDESVLWQLFGPFGAVNNVKVIRDFNTNKCKGFGFVTMTNYDEAAMAIASL 344

Query: 159 NGMLLNGRKVFVGQFKSRKEREA 181
           NG  L G +V    FK+ K  ++
Sbjct: 345 NGYRL-GDRVLQVSFKTNKAHKS 366


>gi|49355765 ELAV-like protein 3 isoform 2 [Homo sapiens]
          Length = 360

 Score = 97.4 bits (241), Expect = 3e-20
 Identities = 78/328 (23%), Positives = 147/328 (44%), Gaps = 61/328 (18%)

Query: 100 NIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAIKK 157
           N+ V  L +++          + G+I SC +V D+    S GYGFV++     A++AI  
Sbjct: 40  NLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINT 99

Query: 158 MNGMLLNGRKVFVGQFKSRKEREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPA 217
           +NG+ L        Q K+ K   A   + +    N+Y+    + M  + ++ LF ++G  
Sbjct: 100 LNGLKL--------QTKTIKVSYARPSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRI 151

Query: 218 LSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEMNGKELNG------------------ 258
           ++ +++ D+ +G S+G GF+ F++  +A++A+  +NG++  G                  
Sbjct: 152 ITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLGAAEPITVKFANNPSQKTG 211

Query: 259 ----KQIYVGRAQK---KVERQTELKR------------TFEQMKQDRITRYQVVNL--- 296
                 +Y   A++    +  QT+  R             F  +  D ++    V L   
Sbjct: 212 QALLTHLYQSSARRYAGPLHHQTQRFRLDNLLNMAYGVKRFSPIAIDGMSGLAGVGLSGG 271

Query: 297 --------YVKNLDDGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEA 346
                   +V NL    D+  L + F PFG +T+ KV+ +    + KGFGFV  ++ +EA
Sbjct: 272 AAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEA 331

Query: 347 TKAVTEMNGRIVATKPLYVALAQRKEER 374
             A+  +NG  +  + L V+    K+ +
Sbjct: 332 AMAIASLNGYRLGERVLQVSFKTSKQHK 359



 Score = 83.6 bits (205), Expect = 5e-16
 Identities = 58/206 (28%), Positives = 101/206 (49%), Gaps = 25/206 (12%)

Query: 184 GARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHE 242
           GA      N+ +    ++M  +  K LFG  G   S K++ D+ +G+S G+GFV++    
Sbjct: 32  GATDDSKTNLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPN 91

Query: 243 DAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLD 302
           DA KA++ +NG +L  K I V  A+                        +  NLYV  L 
Sbjct: 92  DADKAINTLNGLKLQTKTIKVSYARPS------------------SASIRDANLYVSGLP 133

Query: 303 DGIDDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMNGR--IV 358
             +  + + + FS +G I +++++++   G S+G GF+ F    EA +A+  +NG+  + 
Sbjct: 134 KTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKRIEAEEAIKGLNGQKPLG 193

Query: 359 ATKPLYVALAQRKEER--QAYLTNEY 382
           A +P+ V  A    ++  QA LT+ Y
Sbjct: 194 AAEPITVKFANNPSQKTGQALLTHLY 219



 Score = 78.6 bits (192), Expect = 2e-14
 Identities = 45/151 (29%), Positives = 81/151 (53%), Gaps = 4/151 (2%)

Query: 12  SLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDT 71
           +L V  L  ++T+      F   G I S ++ RD IT  S  Y +VN+    DA+ A++T
Sbjct: 40  NLIVNYLPQNMTQDEFKSLFGSIGDIESCKLVRDKITGQSLGYGFVNYSDPNDADKAINT 99

Query: 72  MNFDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVV 131
           +N   ++ K +++ +++  PS       N++V  L K+++ K +    S +G I++  ++
Sbjct: 100 LNGLKLQTKTIKVSYAR--PSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRIL 157

Query: 132 CDE--NGSKGYGFVHFETHEAAERAIKKMNG 160
            D+    S+G GF+ F+    AE AIK +NG
Sbjct: 158 VDQVTGVSRGVGFIRFDKRIEAEEAIKGLNG 188



 Score = 66.2 bits (160), Expect = 8e-11
 Identities = 65/267 (24%), Positives = 115/267 (43%), Gaps = 39/267 (14%)

Query: 3   PSTPSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHT 62
           PS+ S   A+LYV  L   +++  + + FS  G I++ RI  D +T  S    ++ F   
Sbjct: 117 PSSASIRDANLYVSGLPKTMSQKEMEQLFSQYGRIITSRILVDQVTGVSRGVGFIRFDKR 176

Query: 63  KDAEHALDTMNFDVIKG--KPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNK---ALYD 117
            +AE A+  +N     G  +P+ + ++  +PS +    G   + +L +S   +    L+ 
Sbjct: 177 IEAEEAIKGLNGQKPLGAAEPITVKFA-NNPSQK---TGQALLTHLYQSSARRYAGPLHH 232

Query: 118 TVSAFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRK 177
               F          D   +  YG             +K+ + + ++G     G   S  
Sbjct: 233 QTQRFR--------LDNLLNMAYG-------------VKRFSPIAIDGMSGLAGVGLS-- 269

Query: 178 EREAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTD-ESGKSKGFGFV 236
                 G  A     +++ N   + D+  L  LFG FG   +VKV+ D  + K KGFGFV
Sbjct: 270 ------GGAAGAGWCIFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFV 323

Query: 237 SFERHEDAQKAVDEMNGKELNGKQIYV 263
           +   +++A  A+  +NG  L  + + V
Sbjct: 324 TMTNYDEAAMAIASLNGYRLGERVLQV 350



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 28/83 (33%), Positives = 41/83 (49%), Gaps = 3/83 (3%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCD--ENGSKGYGFVHFETHEAAERAIKKM 158
           IFV NL    +   L+     FG + +  V+ D   N  KG+GFV    ++ A  AI  +
Sbjct: 279 IFVYNLSPEADESVLWQLFGPFGAVTNVKVIRDFTTNKCKGFGFVTMTNYDEAAMAIASL 338

Query: 159 NGMLLNGRKVFVGQFKSRKEREA 181
           NG  L G +V    FK+ K+ +A
Sbjct: 339 NGYRL-GERVLQVSFKTSKQHKA 360


>gi|209862867 poly-U binding splicing factor 60KDa isoform c [Homo
           sapiens]
          Length = 516

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 56/192 (29%), Positives = 106/192 (55%), Gaps = 8/192 (4%)

Query: 81  PVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSK 138
           P++ M +QR  +L  + +  ++V ++   +    +    + FG I S ++  D      K
Sbjct: 70  PLQSMAAQRQRAL--AIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHK 127

Query: 139 GYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREA---ELGARAKEFPNVYI 195
           G+ FV +E  EAA+ A+++MN ++L GR + VG+  +  + +    +L   A+ F  +Y+
Sbjct: 128 GFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYV 187

Query: 196 KNFGEDMDDERLKDLFGKFGPALSVKVMTDES-GKSKGFGFVSFERHEDAQKAVDEMNGK 254
            +  +D+ D+ +K +F  FG   S  +  D + GK KG+GF+ +E+ + +Q AV  MN  
Sbjct: 188 ASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLF 247

Query: 255 ELNGKQIYVGRA 266
           +L G+ + VG+A
Sbjct: 248 DLGGQYLRVGKA 259



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 49/171 (28%), Positives = 85/171 (49%), Gaps = 22/171 (12%)

Query: 193 VYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEM 251
           VY+ +   ++ ++ ++  F  FGP  S+ +  D  + K KGF FV +E  E AQ A+++M
Sbjct: 88  VYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQM 147

Query: 252 NGKELNGKQIYVGR------AQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGI 305
           N   L G+ I VGR      AQ  +++  E  R F +             +YV ++   +
Sbjct: 148 NSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNR-------------IYVASVHQDL 194

Query: 306 DDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMN 354
            D+ ++  F  FG I S  +  +   G+ KG+GF+ +   + +  AV+ MN
Sbjct: 195 SDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMN 245



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 45/171 (26%), Positives = 88/171 (51%), Gaps = 11/171 (6%)

Query: 13  LYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDTM 72
           +YVG ++ ++ E  + + F+P GPI SI +  D +T     +A+V ++  + A+ AL+ M
Sbjct: 88  VYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQM 147

Query: 73  NFDVIKGKPVRI----MWSQRDPSL-----RKSGVGNIFVKNLDKSINNKALYDTVSAFG 123
           N  ++ G+ +++       Q  P +            I+V ++ + +++  +     AFG
Sbjct: 148 NSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFG 207

Query: 124 NILSCNVVCDENGS--KGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQ 172
            I SC +  D      KGYGF+ +E  ++++ A+  MN   L G+ + VG+
Sbjct: 208 KIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGK 258



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 22/72 (30%), Positives = 41/72 (56%), Gaps = 2/72 (2%)

Query: 296 LYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEGG--RSKGFGFVCFSSPEEATKAVTEM 353
           +YV ++   + ++ +R+AF+PFG I S  +  +    + KGF FV +  PE A  A+ +M
Sbjct: 88  VYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQM 147

Query: 354 NGRIVATKPLYV 365
           N  ++  + + V
Sbjct: 148 NSVMLGGRNIKV 159


>gi|17978512 poly-U binding splicing factor 60KDa isoform a [Homo
           sapiens]
          Length = 559

 Score = 93.6 bits (231), Expect = 5e-19
 Identities = 56/192 (29%), Positives = 106/192 (55%), Gaps = 8/192 (4%)

Query: 81  PVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSK 138
           P++ M +QR  +L  + +  ++V ++   +    +    + FG I S ++  D      K
Sbjct: 113 PLQSMAAQRQRAL--AIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHK 170

Query: 139 GYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQFKSRKEREA---ELGARAKEFPNVYI 195
           G+ FV +E  EAA+ A+++MN ++L GR + VG+  +  + +    +L   A+ F  +Y+
Sbjct: 171 GFAFVEYEVPEAAQLALEQMNSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYV 230

Query: 196 KNFGEDMDDERLKDLFGKFGPALSVKVMTDES-GKSKGFGFVSFERHEDAQKAVDEMNGK 254
            +  +D+ D+ +K +F  FG   S  +  D + GK KG+GF+ +E+ + +Q AV  MN  
Sbjct: 231 ASVHQDLSDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLF 290

Query: 255 ELNGKQIYVGRA 266
           +L G+ + VG+A
Sbjct: 291 DLGGQYLRVGKA 302



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 49/171 (28%), Positives = 85/171 (49%), Gaps = 22/171 (12%)

Query: 193 VYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEM 251
           VY+ +   ++ ++ ++  F  FGP  S+ +  D  + K KGF FV +E  E AQ A+++M
Sbjct: 131 VYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQM 190

Query: 252 NGKELNGKQIYVGR------AQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGI 305
           N   L G+ I VGR      AQ  +++  E  R F +             +YV ++   +
Sbjct: 191 NSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNR-------------IYVASVHQDL 237

Query: 306 DDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMN 354
            D+ ++  F  FG I S  +  +   G+ KG+GF+ +   + +  AV+ MN
Sbjct: 238 SDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMN 288



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 45/171 (26%), Positives = 88/171 (51%), Gaps = 11/171 (6%)

Query: 13  LYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDTM 72
           +YVG ++ ++ E  + + F+P GPI SI +  D +T     +A+V ++  + A+ AL+ M
Sbjct: 131 VYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQM 190

Query: 73  NFDVIKGKPVRI----MWSQRDPSL-----RKSGVGNIFVKNLDKSINNKALYDTVSAFG 123
           N  ++ G+ +++       Q  P +            I+V ++ + +++  +     AFG
Sbjct: 191 NSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFG 250

Query: 124 NILSCNVVCDENGS--KGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQ 172
            I SC +  D      KGYGF+ +E  ++++ A+  MN   L G+ + VG+
Sbjct: 251 KIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGK 301



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 22/72 (30%), Positives = 41/72 (56%), Gaps = 2/72 (2%)

Query: 296 LYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEGG--RSKGFGFVCFSSPEEATKAVTEM 353
           +YV ++   + ++ +R+AF+PFG I S  +  +    + KGF FV +  PE A  A+ +M
Sbjct: 131 VYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQM 190

Query: 354 NGRIVATKPLYV 365
           N  ++  + + V
Sbjct: 191 NSVMLGGRNIKV 202


>gi|17298690 poly-U binding splicing factor 60KDa isoform b [Homo
           sapiens]
          Length = 542

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 51/172 (29%), Positives = 95/172 (55%), Gaps = 6/172 (3%)

Query: 101 IFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NGSKGYGFVHFETHEAAERAIKKM 158
           ++V ++   +    +    + FG I S ++  D      KG+ FV +E  EAA+ A+++M
Sbjct: 114 VYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQM 173

Query: 159 NGMLLNGRKVFVGQFKSRKEREA---ELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFG 215
           N ++L GR + VG+  +  + +    +L   A+ F  +Y+ +  +D+ D+ +K +F  FG
Sbjct: 174 NSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFG 233

Query: 216 PALSVKVMTDES-GKSKGFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRA 266
              S  +  D + GK KG+GF+ +E+ + +Q AV  MN  +L G+ + VG+A
Sbjct: 234 KIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGKA 285



 Score = 78.2 bits (191), Expect = 2e-14
 Identities = 49/171 (28%), Positives = 85/171 (49%), Gaps = 22/171 (12%)

Query: 193 VYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDE-SGKSKGFGFVSFERHEDAQKAVDEM 251
           VY+ +   ++ ++ ++  F  FGP  S+ +  D  + K KGF FV +E  E AQ A+++M
Sbjct: 114 VYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQM 173

Query: 252 NGKELNGKQIYVGR------AQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDGI 305
           N   L G+ I VGR      AQ  +++  E  R F +             +YV ++   +
Sbjct: 174 NSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNR-------------IYVASVHQDL 220

Query: 306 DDERLRKAFSPFGTITSAKVMME--GGRSKGFGFVCFSSPEEATKAVTEMN 354
            D+ ++  F  FG I S  +  +   G+ KG+GF+ +   + +  AV+ MN
Sbjct: 221 SDDDIKSVFEAFGKIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMN 271



 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 45/171 (26%), Positives = 88/171 (51%), Gaps = 11/171 (6%)

Query: 13  LYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDAEHALDTM 72
           +YVG ++ ++ E  + + F+P GPI SI +  D +T     +A+V ++  + A+ AL+ M
Sbjct: 114 VYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGFAFVEYEVPEAAQLALEQM 173

Query: 73  NFDVIKGKPVRI----MWSQRDPSL-----RKSGVGNIFVKNLDKSINNKALYDTVSAFG 123
           N  ++ G+ +++       Q  P +            I+V ++ + +++  +     AFG
Sbjct: 174 NSVMLGGRNIKVGRPSNIGQAQPIIDQLAEEARAFNRIYVASVHQDLSDDDIKSVFEAFG 233

Query: 124 NILSCNVVCDENGS--KGYGFVHFETHEAAERAIKKMNGMLLNGRKVFVGQ 172
            I SC +  D      KGYGF+ +E  ++++ A+  MN   L G+ + VG+
Sbjct: 234 KIKSCTLARDPTTGKHKGYGFIEYEKAQSSQDAVSSMNLFDLGGQYLRVGK 284



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 37/150 (24%), Positives = 73/150 (48%), Gaps = 8/150 (5%)

Query: 219 SVKVMTDESGKSK-GFGFVSFERHEDAQKAVDEMNGKELNGKQIYVGRAQKKVERQTELK 277
           S+K+   +S  +K G   ++ E+ E  QKA  +    E + K + V   ++ +  Q +  
Sbjct: 41  SIKMENGQSTAAKLGLPPLTPEQQEALQKA--KKYAMEQSIKSVLV---KQTIAHQQQQL 95

Query: 278 RTFEQMKQDRITRYQVVNLYVKNLDDGIDDERLRKAFSPFGTITSAKVMMEGG--RSKGF 335
              +   Q +     +  +YV ++   + ++ +R+AF+PFG I S  +  +    + KGF
Sbjct: 96  TNLQMAAQRQRALAIMCRVYVGSIYYELGEDTIRQAFAPFGPIKSIDMSWDSVTMKHKGF 155

Query: 336 GFVCFSSPEEATKAVTEMNGRIVATKPLYV 365
            FV +  PE A  A+ +MN  ++  + + V
Sbjct: 156 AFVEYEVPEAAQLALEQMNSVMLGGRNIKV 185


>gi|228008400 synaptotagmin binding, cytoplasmic RNA interacting
           protein isoform 6 [Homo sapiens]
          Length = 562

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 75/292 (25%), Positives = 142/292 (48%), Gaps = 30/292 (10%)

Query: 6   PSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDA 65
           PS  T  ++VG +  D+ E  L   F  AGPI  +R+  D +T  +  YA+V F   + A
Sbjct: 158 PSVGT-EIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAA 216

Query: 66  EHALDTMN-FDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS---- 120
           + A+   N  ++  GK + +  S  +          +FV ++ KS   + + +  S    
Sbjct: 217 QEAVKLYNNHEIRSGKHIGVCISVAN--------NRLFVGSIPKSKTKEQILEEFSKVTE 268

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKK-MNGMLLNGRKVFVGQFKSR-KE 178
              +++  +   D+  ++G+ F+ +E H+ A +A ++ M+G +     V   ++    ++
Sbjct: 269 GLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIED 328

Query: 179 REAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSF 238
            + E+ A+ K    ++++N    + +E L+  F +FG    VK       K K + F+ F
Sbjct: 329 PDPEVMAKVKV---LFVRNLANTVTEEILEKAFSQFGKLERVK-------KLKDYAFIHF 378

Query: 239 ERHEDAQKAVDEMNGKELNGKQIYVGRA----QKKVERQTELKRTFEQMKQD 286
           +  + A KA++EMNGK+L G+ I +  A    QK+ ER+ + +    QM  D
Sbjct: 379 DERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDD 430



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 86/326 (26%), Positives = 132/326 (40%), Gaps = 65/326 (19%)

Query: 79  GKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NG 136
           G P   ++S + PS+       IFV  + + +    L       G I    ++ D     
Sbjct: 146 GPPPDSVYSGQQPSVGTE----IFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGL 201

Query: 137 SKGYGFVHFETHEAAERAIKKMNGMLLNGRK------------VFVGQFKSRKEREAELG 184
           ++GY FV F T EAA+ A+K  N   +   K            +FVG     K +E  L 
Sbjct: 202 NRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQIL- 260

Query: 185 ARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDA 244
              +EF  V           E L D+     P        D+  K++GF F+ +E H+ A
Sbjct: 261 ---EEFSKV----------TEGLTDVILYHQP--------DDKKKNRGFCFLEYEDHKTA 299

Query: 245 QKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDG 304
            +A   +    ++GK    G          E     E    + + + +V  L+V+NL + 
Sbjct: 300 AQARRRL----MSGKVKVWGNVGT-----VEWADPIEDPDPEVMAKVKV--LFVRNLANT 348

Query: 305 IDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGR-------- 356
           + +E L KAFS FG +   K      + K + F+ F   + A KA+ EMNG+        
Sbjct: 349 VTEEILEKAFSQFGKLERVK------KLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIE 402

Query: 357 IVATKPLYVALAQRKEERQAYLTNEY 382
           IV  KP      +RK +RQA     Y
Sbjct: 403 IVFAKPPDQKRKERKAQRQAAKNQMY 428


>gi|228008396 synaptotagmin binding, cytoplasmic RNA interacting
           protein isoform 2 [Homo sapiens]
          Length = 464

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 75/292 (25%), Positives = 142/292 (48%), Gaps = 30/292 (10%)

Query: 6   PSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDA 65
           PS  T  ++VG +  D+ E  L   F  AGPI  +R+  D +T  +  YA+V F   + A
Sbjct: 60  PSVGT-EIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAA 118

Query: 66  EHALDTMN-FDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS---- 120
           + A+   N  ++  GK + +  S  +          +FV ++ KS   + + +  S    
Sbjct: 119 QEAVKLYNNHEIRSGKHIGVCISVAN--------NRLFVGSIPKSKTKEQILEEFSKVTE 170

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKK-MNGMLLNGRKVFVGQFKSR-KE 178
              +++  +   D+  ++G+ F+ +E H+ A +A ++ M+G +     V   ++    ++
Sbjct: 171 GLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIED 230

Query: 179 REAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSF 238
            + E+ A+ K    ++++N    + +E L+  F +FG    VK       K K + F+ F
Sbjct: 231 PDPEVMAKVKV---LFVRNLANTVTEEILEKAFSQFGKLERVK-------KLKDYAFIHF 280

Query: 239 ERHEDAQKAVDEMNGKELNGKQIYVGRA----QKKVERQTELKRTFEQMKQD 286
           +  + A KA++EMNGK+L G+ I +  A    QK+ ER+ + +    QM  D
Sbjct: 281 DERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDD 332



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 86/326 (26%), Positives = 132/326 (40%), Gaps = 65/326 (19%)

Query: 79  GKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NG 136
           G P   ++S + PS+       IFV  + + +    L       G I    ++ D     
Sbjct: 48  GPPPDSVYSGQQPSVGTE----IFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGL 103

Query: 137 SKGYGFVHFETHEAAERAIKKMNGMLLNGRK------------VFVGQFKSRKEREAELG 184
           ++GY FV F T EAA+ A+K  N   +   K            +FVG     K +E  L 
Sbjct: 104 NRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQIL- 162

Query: 185 ARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDA 244
              +EF  V           E L D+     P        D+  K++GF F+ +E H+ A
Sbjct: 163 ---EEFSKV----------TEGLTDVILYHQP--------DDKKKNRGFCFLEYEDHKTA 201

Query: 245 QKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDG 304
            +A   +    ++GK    G          E     E    + + + +V  L+V+NL + 
Sbjct: 202 AQARRRL----MSGKVKVWGNVGT-----VEWADPIEDPDPEVMAKVKV--LFVRNLANT 250

Query: 305 IDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGR-------- 356
           + +E L KAFS FG +   K      + K + F+ F   + A KA+ EMNG+        
Sbjct: 251 VTEEILEKAFSQFGKLERVK------KLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIE 304

Query: 357 IVATKPLYVALAQRKEERQAYLTNEY 382
           IV  KP      +RK +RQA     Y
Sbjct: 305 IVFAKPPDQKRKERKAQRQAAKNQMY 330


>gi|228008293 synaptotagmin binding, cytoplasmic RNA interacting
           protein isoform 5 [Homo sapiens]
          Length = 561

 Score = 89.0 bits (219), Expect = 1e-17
 Identities = 75/292 (25%), Positives = 142/292 (48%), Gaps = 30/292 (10%)

Query: 6   PSYPTASLYVGDLHPDVTEAMLYEKFSPAGPILSIRICRDLITSGSSNYAYVNFQHTKDA 65
           PS  T  ++VG +  D+ E  L   F  AGPI  +R+  D +T  +  YA+V F   + A
Sbjct: 158 PSVGT-EIFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGLNRGYAFVTFCTKEAA 216

Query: 66  EHALDTMN-FDVIKGKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVS---- 120
           + A+   N  ++  GK + +  S  +          +FV ++ KS   + + +  S    
Sbjct: 217 QEAVKLYNNHEIRSGKHIGVCISVAN--------NRLFVGSIPKSKTKEQILEEFSKVTE 268

Query: 121 AFGNILSCNVVCDENGSKGYGFVHFETHEAAERAIKK-MNGMLLNGRKVFVGQFKSR-KE 178
              +++  +   D+  ++G+ F+ +E H+ A +A ++ M+G +     V   ++    ++
Sbjct: 269 GLTDVILYHQPDDKKKNRGFCFLEYEDHKTAAQARRRLMSGKVKVWGNVGTVEWADPIED 328

Query: 179 REAELGARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSF 238
            + E+ A+ K    ++++N    + +E L+  F +FG    VK       K K + F+ F
Sbjct: 329 PDPEVMAKVKV---LFVRNLANTVTEEILEKAFSQFGKLERVK-------KLKDYAFIHF 378

Query: 239 ERHEDAQKAVDEMNGKELNGKQIYVGRA----QKKVERQTELKRTFEQMKQD 286
           +  + A KA++EMNGK+L G+ I +  A    QK+ ER+ + +    QM  D
Sbjct: 379 DERDGAVKAMEEMNGKDLEGENIEIVFAKPPDQKRKERKAQRQAAKNQMYDD 430



 Score = 72.8 bits (177), Expect = 9e-13
 Identities = 86/326 (26%), Positives = 132/326 (40%), Gaps = 65/326 (19%)

Query: 79  GKPVRIMWSQRDPSLRKSGVGNIFVKNLDKSINNKALYDTVSAFGNILSCNVVCDE--NG 136
           G P   ++S + PS+       IFV  + + +    L       G I    ++ D     
Sbjct: 146 GPPPDSVYSGQQPSVGTE----IFVGKIPRDLFEDELVPLFEKAGPIWDLRLMMDPLTGL 201

Query: 137 SKGYGFVHFETHEAAERAIKKMNGMLLNGRK------------VFVGQFKSRKEREAELG 184
           ++GY FV F T EAA+ A+K  N   +   K            +FVG     K +E  L 
Sbjct: 202 NRGYAFVTFCTKEAAQEAVKLYNNHEIRSGKHIGVCISVANNRLFVGSIPKSKTKEQIL- 260

Query: 185 ARAKEFPNVYIKNFGEDMDDERLKDLFGKFGPALSVKVMTDESGKSKGFGFVSFERHEDA 244
              +EF  V           E L D+     P        D+  K++GF F+ +E H+ A
Sbjct: 261 ---EEFSKV----------TEGLTDVILYHQP--------DDKKKNRGFCFLEYEDHKTA 299

Query: 245 QKAVDEMNGKELNGKQIYVGRAQKKVERQTELKRTFEQMKQDRITRYQVVNLYVKNLDDG 304
            +A   +    ++GK    G          E     E    + + + +V  L+V+NL + 
Sbjct: 300 AQARRRL----MSGKVKVWGNVGT-----VEWADPIEDPDPEVMAKVKV--LFVRNLANT 348

Query: 305 IDDERLRKAFSPFGTITSAKVMMEGGRSKGFGFVCFSSPEEATKAVTEMNGR-------- 356
           + +E L KAFS FG +   K      + K + F+ F   + A KA+ EMNG+        
Sbjct: 349 VTEEILEKAFSQFGKLERVK------KLKDYAFIHFDERDGAVKAMEEMNGKDLEGENIE 402

Query: 357 IVATKPLYVALAQRKEERQAYLTNEY 382
           IV  KP      +RK +RQA     Y
Sbjct: 403 IVFAKPPDQKRKERKAQRQAAKNQMY 428


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.316    0.130    0.372 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 23,567,539
Number of Sequences: 37866
Number of extensions: 1107855
Number of successful extensions: 6971
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 250
Number of HSP's successfully gapped in prelim test: 227
Number of HSP's that attempted gapping in prelim test: 4756
Number of HSP's gapped (non-prelim): 1503
length of query: 631
length of database: 18,247,518
effective HSP length: 108
effective length of query: 523
effective length of database: 14,157,990
effective search space: 7404628770
effective search space used: 7404628770
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.