Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 4507157
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4507157 sortilin-related receptor containing LDLR class A
repeats preproprotein [Homo sapiens]
(2214 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4507157 sortilin-related receptor containing LDLR class A rep... 4636 0.0
gi|126012562 low density lipoprotein-related protein 1 [Homo sap... 485 e-136
gi|126012573 low density lipoprotein-related protein 2 [Homo sap... 479 e-134
gi|93102379 low density lipoprotein-related protein 1B precursor... 432 e-120
gi|157384998 low density lipoprotein receptor-related protein 4 ... 275 3e-73
gi|170014689 VPS10 domain receptor protein SORCS 2 [Homo sapiens] 260 9e-69
gi|18379346 VPS10 domain receptor protein SORCS 3 [Homo sapiens] 259 2e-68
gi|61743975 SORCS receptor 1 isoform b [Homo sapiens] 254 9e-67
gi|61743973 SORCS receptor 1 isoform a [Homo sapiens] 254 9e-67
gi|65301164 very low density lipoprotein receptor isoform b [Hom... 252 3e-66
gi|65301167 very low density lipoprotein receptor isoform a [Hom... 252 3e-66
gi|17149834 sortilin 1 preproprotein [Homo sapiens] 250 9e-66
gi|4504975 low density lipoprotein receptor precursor [Homo sapi... 226 1e-58
gi|61744471 low density lipoprotein receptor-related protein 8 i... 225 4e-58
gi|65301119 low density lipoprotein receptor-related protein 8 i... 225 4e-58
gi|29244926 corin [Homo sapiens] 224 6e-58
gi|148727288 low density lipoprotein receptor-related protein 6 ... 204 6e-52
gi|119709832 low density lipoprotein receptor-related protein 5 ... 198 6e-50
gi|134031945 SCO-spondin [Homo sapiens] 187 1e-46
gi|61744467 low density lipoprotein receptor-related protein 8 i... 166 2e-40
gi|66082554 low density lipoprotein receptor-related protein 8 i... 166 2e-40
gi|11415040 matriptase [Homo sapiens] 130 2e-29
gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens] 127 9e-29
gi|144953895 nidogen 2 precursor [Homo sapiens] 124 8e-28
gi|208973262 low density lipoprotein-related protein 12 isoform ... 124 1e-27
gi|7305525 low density lipoprotein-related protein 12 isoform a ... 124 1e-27
gi|166362728 epidermal growth factor (beta-urogastrone) [Homo sa... 123 2e-27
gi|32698824 low density lipoprotein receptor-related protein 5-l... 122 4e-27
gi|209447022 low density lipoprotein receptor-related protein 5-... 122 4e-27
gi|167555125 low density lipoprotein receptor-related protein 3 ... 121 7e-27
>gi|4507157 sortilin-related receptor containing LDLR class A repeats
preproprotein [Homo sapiens]
Length = 2214
Score = 4636 bits (12025), Expect = 0.0
Identities = 2214/2214 (100%), Positives = 2214/2214 (100%)
Query: 1 MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRL 60
MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRL
Sbjct: 1 MATRSSRRESRLPFLFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRL 60
Query: 61 WARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVAL 120
WARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVAL
Sbjct: 61 WARGDARGASRADEKPLRRKRSAALQPEPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVAL 120
Query: 121 ARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFA 180
ARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFA
Sbjct: 121 ARDSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFA 180
Query: 181 DAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQT 240
DAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQT
Sbjct: 181 DAYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQT 240
Query: 241 WIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDF 300
WIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDF
Sbjct: 241 WIMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQEVILEEVRDF 300
Query: 301 QLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVF 360
QLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVF
Sbjct: 301 QLRDKYMFATKVVHLLGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVF 360
Query: 361 VCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGL 420
VCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGL
Sbjct: 361 VCVSHSNNRTNLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGL 420
Query: 421 QGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQR 480
QGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQR
Sbjct: 421 QGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQR 480
Query: 481 LSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYY 540
LSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYY
Sbjct: 481 LSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKTNVYISSSAGARWREALPGPHYY 540
Query: 541 TWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIF 600
TWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIF
Sbjct: 541 TWGDHGGIITAIAQGMETNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIF 600
Query: 601 GSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATC 660
GSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATC
Sbjct: 601 GSNKENVHSWLILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATC 660
Query: 661 FNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGS 720
FNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGS
Sbjct: 661 FNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGS 720
Query: 721 TYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATE 780
TYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATE
Sbjct: 721 TYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATE 780
Query: 781 QLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFE 840
QLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFE
Sbjct: 781 QLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFE 840
Query: 841 PLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKP 900
PLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKP
Sbjct: 841 PLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKP 900
Query: 901 GIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNL 960
GIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNL
Sbjct: 901 GIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERITFSGQQRSVILDNL 960
Query: 961 PHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNA 1020
PHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNA
Sbjct: 961 PHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNA 1020
Query: 1021 CVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLR 1080
CVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLR
Sbjct: 1021 CVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLR 1080
Query: 1081 NQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDL 1140
NQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDL
Sbjct: 1081 NQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDL 1140
Query: 1141 EDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCE 1200
EDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCE
Sbjct: 1141 EDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCE 1200
Query: 1201 ASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLR 1260
ASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLR
Sbjct: 1201 ASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLR 1260
Query: 1261 DCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPE 1320
DCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPE
Sbjct: 1261 DCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPE 1320
Query: 1321 FHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGH 1380
FHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGH
Sbjct: 1321 FHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGH 1380
Query: 1381 CIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDG 1440
CIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDG
Sbjct: 1381 CIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDG 1440
Query: 1441 YRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDG 1500
YRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDG
Sbjct: 1441 YRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDG 1500
Query: 1501 RDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQN 1560
RDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQN
Sbjct: 1501 RDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYKVQN 1560
Query: 1561 LQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPD 1620
LQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPD
Sbjct: 1561 LQWTADFSGDVTLTWMRPKKMPSASCVYNVYYRVVGESIWKTLETHSNKTNTVLKVLKPD 1620
Query: 1621 TTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTH 1680
TTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTH
Sbjct: 1621 TTYQVKVQVQCLSKAHNTNDFVTLRTPEGLPDAPRNLQLSLPREAEGVIVGHWAPPIHTH 1680
Query: 1681 GLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSI 1740
GLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSI
Sbjct: 1681 GLIREYIVEYSRSGSKMWASQRAASNFTEIKNLLVNTLYTVRVAAVTSRGIGNWSDSKSI 1740
Query: 1741 TTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRG 1800
TTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRG
Sbjct: 1741 TTIKGKVIPPPDIHIDSYGENYLSFTLTMESDIKVNGYVVNLFWAFDTHKQERRTLNFRG 1800
Query: 1801 SILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVEC 1860
SILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVEC
Sbjct: 1801 SILSHKVGNLTAHTSYEISAWAKTDLGDSPLAFEHVMTRGVRPPAPSLKAKAINQTAVEC 1860
Query: 1861 TWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSS 1920
TWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSS
Sbjct: 1861 TWTGPRNVVYGIFYATSFLDLYRNPKSLTTSLHNKTVIVSKDEQYLFLVRVVVPYQGPSS 1920
Query: 1921 DYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSY 1980
DYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSY
Sbjct: 1921 DYVVVKMIPDSRLPPRHLHVVHTGKTSVVIKWESPYDSPDQDLLYAIAVKDLIRKTDRSY 1980
Query: 1981 KVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVL 2040
KVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVL
Sbjct: 1981 KVKSRNSTVEYTLNKLEPGGKYHIIVQLGNMSKDSSIKITTVSLSAPDALKIITENDHVL 2040
Query: 2041 LFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQAR 2100
LFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQAR
Sbjct: 2041 LFWKSLALKEKHFNESRGYEIHMFDSAMNITAYLGNTTDNFFKISNLKMGHNYTFTVQAR 2100
Query: 2101 CLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYT 2160
CLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYT
Sbjct: 2101 CLFGNQICGEPAILLYDELGSGADASATQAARSTDVAAVVVPILFLILLSLGVGFAILYT 2160
Query: 2161 KHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA 2214
KHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA
Sbjct: 2161 KHRRLQSSFTAFANSHYSSRLGSAIFSSGDDLGEDDEDAPMITGFSDDVPMVIA 2214
>gi|126012562 low density lipoprotein-related protein 1 [Homo sapiens]
Length = 4544
Score = 485 bits (1248), Expect = e-136
Identities = 304/820 (37%), Positives = 416/820 (50%), Gaps = 89/820 (10%)
Query: 754 LAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALD--V 811
+ +E F+++A R + + +L G+ L GL AVALDFDY +YW+D+ +
Sbjct: 3024 VTDEEPFLIFANRYYLRKLNL-DGSNYTLLKQGLNNAVALDFDYREQMIYWTDVTTQGSM 3082
Query: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
I+R+ LNGS Q V+ +GL + LA + + LYW D G IEV+ +G +R T++
Sbjct: 3083 IRRMHLNGSNVQ-VLHRTGLSNPDGLAVDWVGGNLYWCDKGRDTIEVSKLNGAYR-TVLV 3140
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
SS L PRALV+ Q G ++WTDWGD I R MDGS+ +V + WPNG+++D
Sbjct: 3141 SSGLREPRALVVDVQNGYLYWTDWGDHSL-IGRIGMDGSSRSVIVDTKITWPNGLTLDYV 3199
Query: 930 DQWIYWTDAYLECIERITFSGQQRSVILD-NLPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
+ IYW DA + IE + G R V+L ++PH +A+ +F++ +YW DW SI RA K
Sbjct: 3200 TERIYWADAREDYIEFASLDGSNRHVVLSQDIPHIFALTLFEDYVYWTDWETKSINRAHK 3259
Query: 989 YSGSQMEILANQLTGLMDMKIFY--KGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPE 1044
+G+ +L + L MD+ +F+ + + ++ C CS LCL C CP
Sbjct: 3260 TTGTNKTLLISTLHRPMDLHVFHALRQPDVPNHPCKVNNGGCSNLCLLSPGGGHKCACP- 3318
Query: 1045 DVSSSVLPSGDLMC--DCPQG-YQLKNNTCVK---------------------EENTCLR 1080
++ L S C +C + KN+ C+ E C
Sbjct: 3319 --TNFYLGSDGRTCVSNCTASQFVCKNDKCIPFWWKCDTEDDCGDHSDEPPDCPEFKCRP 3376
Query: 1081 NQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDL 1140
Q++CS G C N + CD DNDC D SDE NC +C L +QF+C + CIP ++C+
Sbjct: 3377 GQFQCSTGICTNPAFICDGDNDCQDNSDEANCDIHVC-LPSQFKCTNTNRCIPGIFRCNG 3435
Query: 1141 EDDCGDNSDESHCEMHQCRSDEYNCS-SGMCIRSSWVCDGDNDCRDWSDE-ANCTAIYHT 1198
+D+CGD DE C C +++ CS + CI WVCD DNDC D SDE ANCT + T
Sbjct: 3436 QDNCGDGEDERDCPEVTCAPNQFQCSITKRCIPRVWVCDRDNDCVDGSDEPANCTQM--T 3493
Query: 1199 CEASNFQCR-NGHCIPQRWACDGDTDCQDGSDEDPVNC-EKKCN--GFRCPNGTCIPSSK 1254
C F+C+ +G CIP RW CDG+ DC DGSDE C E+ C FRC N C+P
Sbjct: 3494 CGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEPKEECDERTCEPYQFRCKNNRCVPGRW 3553
Query: 1255 HCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAG 1314
CD DC D SDE+ C P +F C N +C+ CDG C DGSDE
Sbjct: 3554 QCDYDNDCGDNSDEESCTPRPCSESEFSCAN-GRCIAGRWKCDGDHDCADGSDEKDCTPR 3612
Query: 1315 CSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQF 1374
C D FQC++G CI L W+CD DC D SDE C T C +F
Sbjct: 3613 CDMDQ----------FQCKSGHCIPLRWRCDADADCMDGSDEEAC--GTGVRTCP-LDEF 3659
Query: 1375 RCENGHCIPNRWKCDRENDCGDWSDE--KDCGDSHILPFSTPGPSTCLPNY-YRCSSG-T 1430
+C N C P WKCD E+DCGD SDE ++C C PN +RC +
Sbjct: 3660 QCNNTLCKPLAWKCDGEDDCGDNSDENPEEC-----------ARFVCPPNRPFRCKNDRV 3708
Query: 1431 CVMDTWVCDGYRDCADGSDEEAC-PLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWK 1489
C+ CDG +C DG+DEE C P A+ T D+ EF C + C+ +
Sbjct: 3709 CLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCK--------DKKEFLCRNQR-CLSSSL 3759
Query: 1490 RCDGHQDCQDGRDEANCPTHSTLT-CMSREFQCEDGEACI 1528
RC+ DC DG DE +C LT C + C D C+
Sbjct: 3760 RCNMFDDCGDGSDEEDCSIDPKLTSCATNASICGDEARCV 3799
Score = 387 bits (994), Expect = e-107
Identities = 265/821 (32%), Positives = 378/821 (46%), Gaps = 126/821 (15%)
Query: 787 LRAAVALDFDYEH-------NCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAF 839
++ +AL FDY N +++SD+ IQ++ +GS ++ N G +VE LA+
Sbjct: 2233 MKNVIALAFDYRAGTSPGTPNRIFFSDIHFGNIQQINDDGSRRITIVENVG--SVEGLAY 2290
Query: 840 EPLSQLLYWVDAGFKKI-----EVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTD 894
LYW I + P R T++ S D PRA VL + +MFWT+
Sbjct: 2291 HRGWDTLYWTSYTTSTITRHTVDQTRPGAFERETVITMSGDDHPRAFVLDECQNLMFWTN 2350
Query: 895 WGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDD--QWIYWTDAYLECIERITFSGQQ 952
W + P I R+ + G+ L+ +D++ PNG+++D + +Y++DA L+ IER + G
Sbjct: 2351 WNEQHPSIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSH 2410
Query: 953 RSVILDNLP-HPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFY 1011
R VIL + P HP+ +AV+ I+W DW + ++ RA+K+ GS M++L + M I
Sbjct: 2411 RYVILKSEPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQ-QPMGIIA 2469
Query: 1012 KGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNN-T 1070
+T N+C PC + N+ C +D+ + G + C C G L+++ T
Sbjct: 2470 VANDT--NSCELSPCRI-------NNGGC---QDLCL-LTHQGHVNCSCRGGRILQDDLT 2516
Query: 1071 CVKEENTC-LRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESG 1129
C ++C ++++ C+NG CIN CD C D SDE+ FR +G
Sbjct: 2517 CRAVNSSCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNG 2576
Query: 1130 TCIPLSYKCDLEDDCGDNSDESHCEMHQC---------------------------RSDE 1162
C+ C+ DDCGD SDE C C SDE
Sbjct: 2577 RCVSNMLWCNGADDCGDGSDEIPCNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDE 2636
Query: 1163 YNCS----------------------SGMCIRSSWVCDGDNDCRDWSDEANCTAIYH-TC 1199
NCS + +C SWVCDG NDC D+SDE +C + C
Sbjct: 2637 MNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDCGDYSDERDCPGVKRPRC 2696
Query: 1200 EASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCN--GFRCPNGTCIPSSKHCD 1257
+ F C +G CIP W CD + DC+ G DE +C K C+ F C N CI CD
Sbjct: 2697 PLNYFACPSGRCIPMSWTCDKEDDCEHGEDE--THCNKFCSEAQFECQNHRCISKQWLCD 2754
Query: 1258 GLRDCSDGSDE-QHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCS 1316
G DC DGSDE HCE F C C+ +CDG C DG+DE A AGC
Sbjct: 2755 GSDDCGDGSDEAAHCEGKTCGPSSFSCPGTHVCVPERWLCDGDKDCADGADESIA-AGCL 2813
Query: 1317 QDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEA-NCENPTEAPNCSRYFQFR 1375
++ CD+ F CQN CI + CD DC D SDE+ CE PT P+ +FR
Sbjct: 2814 ----YNSTCDDREFMCQNRQCIPKHFVCDHDRDCADGSDESPECEYPTCGPS-----EFR 2864
Query: 1376 CENGHCIPNR-WKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTC-LPNYYRCSSGTCVM 1433
C NG C+ +R W+CD ENDC D SDE P T C + + CSSG CV
Sbjct: 2865 CANGRCLSSRQWECDGENDCHDQSDEAPKN-----PHCTSQEHKCNASSQFLCSSGRCVA 2919
Query: 1434 DTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCD------RFEFECHQPKTCIPN 1487
+ +C+G DC D SDE C + ++ +L C + F+C C P
Sbjct: 2920 EALLCNGQDDCGDSSDERGCHINECLS-----RKLSGCSQDCEDLKIGFKCR----CRPG 2970
Query: 1488 WKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACI 1528
++ D + C D DE + +T C R C+
Sbjct: 2971 FRLKDDGRTCAD-VDECS----TTFPCSQRCINTHGSYKCL 3006
Score = 345 bits (885), Expect = 3e-94
Identities = 258/788 (32%), Positives = 370/788 (46%), Gaps = 93/788 (11%)
Query: 752 CPLAEENEFILYAV-RKSIYR-YDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDL 807
C E F++Y R I R D+ + ++ +P+ L ALDF E +Y++D
Sbjct: 519 CKKPEHELFLVYGKGRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADT 578
Query: 808 ALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKK-IEVANPD--GD 864
+I R ++G T +E I+ G+ VE +A + + LYW D G KK I VA +
Sbjct: 579 TSYLIGRQKIDG-TERETILKDGIHNVEGVAVDWMGDNLYWTDDGPKKTISVARLEKAAQ 637
Query: 865 FRLTIVNSSVLDRPRALVLVPQEGVMFWTDWG----DLKPG-IYRSNMDGSAA-YHLVSE 918
R T++ + PRA+V+ P G M+WTDW D + G + R+ MDGS + S+
Sbjct: 638 TRKTLIEGK-MTHPRAIVVDPLNGWMYWTDWEEDPKDSRRGRLERAWMDGSHRDIFVTSK 696
Query: 919 DVKWPNGISVDDQW--IYWTDAYLECIERITFSGQQRSVILDN--LPHPYAIAVFKNEIY 974
V WPNG+S+D +YW DA+ + IE I +G R ++ + L H + + N ++
Sbjct: 697 TVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDRKIVYEGPELNHAFGLCHHGNYLF 756
Query: 975 WDDWSQLSIFRASKYSGSQ---MEILANQLTGLMDMKIF-YKGKNTGSNACVPRP--CSL 1028
W ++ S++R + G + +L ++ + +++++ + + G+N C CS
Sbjct: 757 WTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIRMYDAQQQQVGTNKCRVNNGGCSS 816
Query: 1029 LCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNG 1088
LCL SR C C ED VL + + C L N + V C ++ C+N
Sbjct: 817 LCLATPG-SRQCACAED---QVLDADGVTC-------LANPSYVPPPQ-CQPGEFACANS 864
Query: 1089 NCINSIWWCDFDNDCGDMSDERN--CPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGD 1146
CI W CD DNDC D SDE C C D +F+C E+ CIP + CD ++DCG+
Sbjct: 865 RCIQERWKCDGDNDCLDNSDEAPALCHQHTCPSD-RFKC-ENNRCIPNRWLCDGDNDCGN 922
Query: 1147 NSDESH--CEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTC-EASN 1203
+ DES+ C C ++++C+SG CI SW CD D+DC D SDE+ A Y TC +
Sbjct: 923 SEDESNATCSARTCPPNQFSCASGRCIPISWTCDLDDDCGDRSDESASCA-YPTCFPLTQ 981
Query: 1204 FQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG--FRCPNGTCIPSSKHCDGLRD 1261
F C NG CI W CD D DC D SDE C C+ F+C +G CIP CDG D
Sbjct: 982 FTCNNGRCININWRCDNDNDCGDNSDE--AGCSHSCSSTQFKCNSGRCIPEHWTCDGDND 1039
Query: 1262 CSDGSDEQHCE--------PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFA 1313
C D SDE H P H +F C+ C+ CDG C D SDE +
Sbjct: 1040 CGDYSDETHANCTNQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSC-E 1098
Query: 1314 GCSQDPEFHKVCD-EFGFQCQNGV-CISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRY 1371
G + VCD F C++ CIS W CDG +DC D SDE NCE+ P
Sbjct: 1099 GVTH------VCDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLACRPP---- 1148
Query: 1372 FQFRCENGH--CIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSG 1429
C N C+P CD +DCGD SDE + D C N CS
Sbjct: 1149 -SHPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQ------------CSLNNGGCSHN 1195
Query: 1430 TCVM--DTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEF----ECHQPKT 1483
V + VC G D C + + +Q +CD+ +F C++
Sbjct: 1196 CSVAPGEGIVCSCPLGMELGPDNHTCQIQSYCAKHLKCSQ--KCDQNKFSVKCSCYEGWV 1253
Query: 1484 CIPNWKRC 1491
P+ + C
Sbjct: 1254 LEPDGESC 1261
Score = 283 bits (723), Expect = 2e-75
Identities = 224/762 (29%), Positives = 310/762 (40%), Gaps = 148/762 (19%)
Query: 875 LDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQW-- 932
L PRAL + G +++ D G R +DG+ ++ + + G++VD W
Sbjct: 558 LMNPRALDFHAETGFIYFADTTSYLIG--RQKIDGTERETILKDGIHNVEGVAVD--WMG 613
Query: 933 --IYWTDAYLE---CIERITFSGQQRSVILDN-LPHPYAIAV--FKNEIYWDDW------ 978
+YWTD + + R+ + Q R +++ + HP AI V +YW DW
Sbjct: 614 DNLYWTDDGPKKTISVARLEKAAQTRKTLIEGKMTHPRAIVVDPLNGWMYWTDWEEDPKD 673
Query: 979 -------------SQLSIFRASKY----SGSQMEILANQLTGL--------------MDM 1007
S IF SK +G ++I A +L + D
Sbjct: 674 SRRGRLERAWMDGSHRDIFVTSKTVLWPNGLSLDIPAGRLYWVDAFYDRIETILLNGTDR 733
Query: 1008 KIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLK 1067
KI Y+G + + L + + R V + L + P ++++
Sbjct: 734 KIVYEGPELNHAFGLCHHGNYLFWTEYRSGSVYRLERGVGGAPPTVTLLRSERPPIFEIR 793
Query: 1068 NNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQE 1127
+++ N+ R +NG C + C D+ + D D
Sbjct: 794 MYDAQQQQVGT--NKCRVNNGGCSSLCLATPGSRQCACAEDQ------VLDAD------- 838
Query: 1128 SGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWS 1187
TC+ ++ S+ QC+ E+ C++ CI+ W CDGDNDC D S
Sbjct: 839 GVTCL---------------ANPSYVPPPQCQPGEFACANSRCIQERWKCDGDNDCLDNS 883
Query: 1188 DEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKC---NGFRC 1244
DEA HTC + F+C N CIP RW CDGD DC + DE C + N F C
Sbjct: 884 DEAPALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDCGNSEDESNATCSARTCPPNQFSC 943
Query: 1245 PNGTCIPSSKHCDGLRDCSDGSDEQH--CEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQC 1302
+G CIP S CD DC D SDE P C F C N + C+ + CD C
Sbjct: 944 ASGRCIPISWTCDLDDDCGDRSDESASCAYPTCFPLTQFTCNNGR-CININWRCDNDNDC 1002
Query: 1303 RDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE--ANCE 1360
D SDE AGCS C F+C +G CI W CDG +DCGDYSDE ANC
Sbjct: 1003 GDNSDE----AGCSHS------CSSTQFKCNSGRCIPEHWTCDGDNDCGDYSDETHANCT 1052
Query: 1361 NP-TEAPNCSRYFQFRCE-NGHCIPNRWKCDRENDCGDWSDEKDC-GDSHILPFSTPGPS 1417
N T P +F+C +G CIP RW+CD + DC D SDEK C G +H+
Sbjct: 1053 NQATRPPGGCHTDEFQCRLDGLCIPLRWRCDGDTDCMDSSDEKSCEGVTHV--------- 1103
Query: 1418 TCLPNY-YRCS-SGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFE 1475
C P+ + C S C+ WVCDG DC D SDEE C LA C
Sbjct: 1104 -CDPSVKFGCKDSARCISKAWVCDGDNDCEDNSDEENCESLA-------------CRPPS 1149
Query: 1476 FEC-HQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCE------------ 1522
C + C+P K CDG+ DC DG DE +L C
Sbjct: 1150 HPCANNTSVCLPPDKLCDGNDDCGDGSDEGELCDQCSLNNGGCSHNCSVAPGEGIVCSCP 1209
Query: 1523 -------DGEACIVLSERCDGFLDCSDESDEKACSDELTVYK 1557
D C + S C L CS + D+ S + + Y+
Sbjct: 1210 LGMELGPDNHTCQIQS-YCAKHLKCSQKCDQNKFSVKCSCYE 1250
Score = 253 bits (647), Expect = 1e-66
Identities = 161/431 (37%), Positives = 200/431 (46%), Gaps = 77/431 (17%)
Query: 1156 HQCRSDEYNCSSGMCIRS---SWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCI 1212
H C+ + CS+ +C+ S C + SD C + C AS F C+N CI
Sbjct: 3292 HPCKVNNGGCSN-LCLLSPGGGHKCACPTNFYLGSDGRTCVS---NCTASQFVCKNDKCI 3347
Query: 1213 PQRWACDGDTDCQDGSDEDPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQH 1270
P W CD + DC D SDE P E KC F+C G C + CDG DC D SDE +
Sbjct: 3348 PFWWKCDTEDDCGDHSDEPPDCPEFKCRPGQFQCSTGICTNPAFICDGDNDCQDNSDEAN 3407
Query: 1271 CEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE-DAAFAGC-------------- 1315
C+ F C N +C+ C+G C DG DE D C
Sbjct: 3408 CDIHVCLPSQFKCTNTNRCIPGIFRCNGQDNCGDGEDERDCPEVTCAPNQFQCSITKRCI 3467
Query: 1316 ---------------SQDPE--FHKVCDEFGFQCQ-NGVCISLIWKCDGMDDCGDYSDE- 1356
S +P C F+C+ +G CI WKCDG DDCGD SDE
Sbjct: 3468 PRVWVCDRDNDCVDGSDEPANCTQMTCGVDEFRCKDSGRCIPARWKCDGEDDCGDGSDEP 3527
Query: 1357 -ANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPG 1415
C+ T P +QFRC+N C+P RW+CD +NDCGD SDE+ C TP
Sbjct: 3528 KEECDERTCEP-----YQFRCKNNRCVPGRWQCDYDNDCGDNSDEESC---------TPR 3573
Query: 1416 PSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFE 1475
P C + + C++G C+ W CDG DCADGSDE+ C TP RCD +
Sbjct: 3574 P--CSESEFSCANGRCIAGRWKCDGDHDCADGSDEKDC----------TP----RCDMDQ 3617
Query: 1476 FECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCD 1535
F+C + CIP RCD DC DG DE C T TC EFQC + C L+ +CD
Sbjct: 3618 FQC-KSGHCIPLRWRCDADADCMDGSDEEACGT-GVRTCPLDEFQC-NNTLCKPLAWKCD 3674
Query: 1536 GFLDCSDESDE 1546
G DC D SDE
Sbjct: 3675 GEDDCGDNSDE 3685
Score = 249 bits (637), Expect = 2e-65
Identities = 211/691 (30%), Positives = 293/691 (42%), Gaps = 111/691 (16%)
Query: 902 IYRSNMDGSAAYHLVSEDVKWPNGISVDDQW--IYWTDAYLECIERITFSGQ-----QRS 954
I + N DGS +V E+V G++ W +YWT I R T +R
Sbjct: 2265 IQQINDDGSRRITIV-ENVGSVEGLAYHRGWDTLYWTSYTTSTITRHTVDQTRPGAFERE 2323
Query: 955 VIL----DNLPHPYAIAVFKNEIYWDDWSQL--SIFRASKYSGSQMEILANQLTGLMDMK 1008
++ D+ P + + +N ++W +W++ SI RA+ L+G +
Sbjct: 2324 TVITMSGDDHPRAFVLDECQNLMFWTNWNEQHPSIMRAA-------------LSGANVLT 2370
Query: 1009 IFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSS--VLPSGDLMCDCPQGYQL 1066
+ K T + + L A + RC D S +L S + P G +
Sbjct: 2371 LIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGSHRYVILKSEPVH---PFGLAV 2427
Query: 1067 KNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDM------SDERNCPTTICDLD 1120
+ +R + +N + +++ D M +D +C + C ++
Sbjct: 2428 YGEHIFWTD--WVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVANDTNSCELSPCRIN 2485
Query: 1121 TQFRCQESGTCIPLSYKCDLEDDCGDN---SDESHCEM--HQCRS-DEYNCSSGMCIRSS 1174
CQ+ C+ L+++ + C D+ C CR+ DE+ C++G CI S
Sbjct: 2486 NG-GCQD--LCL-LTHQGHVNCSCRGGRILQDDLTCRAVNSSCRAQDEFECANGECINFS 2541
Query: 1175 WVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVN 1234
CDG C+D SDE C+ + QC NG C+ C+G DC DGSDE P
Sbjct: 2542 LTCDGVPHCKDKSDEKPSYCNSRRCKKTFRQCSNGRCVSNMLWCNGADDCGDGSDEIP-- 2599
Query: 1235 CEKKCNG---FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPL-CTHFMDF--------V 1282
C K G FRC +GTCI +S C+ DC D SDE +C C+ +
Sbjct: 2600 CNKTACGVGEFRCRDGTCIGNSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQP 2659
Query: 1283 CKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIW 1342
C+ C S VCDG C D SDE G + C F C +G CI + W
Sbjct: 2660 CERTSLCYAPSWVCDGANDCGDYSDERDC-PGVKRPR-----CPLNYFACPSGRCIPMSW 2713
Query: 1343 KCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE-- 1400
CD DDC DE +C CS QF C+N CI +W CD +DCGD SDE
Sbjct: 2714 TCDKEDDCEHGEDETHCNK-----FCSE-AQFECQNHRCISKQWLCDGSDDCGDGSDEAA 2767
Query: 1401 ----KDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEE-ACPL 1455
K CG S FS PG C+P + W+CDG +DCADG+DE A
Sbjct: 2768 HCEGKTCGPS---SFSCPGTHVCVP------------ERWLCDGDKDCADGADESIAAGC 2812
Query: 1456 LANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCM 1515
L N T CD EF C Q + CIP CD +DC DG DE+ P TC
Sbjct: 2813 LYNST----------CDDREFMC-QNRQCIPKHFVCDHDRDCADGSDES--PECEYPTCG 2859
Query: 1516 SREFQCEDGEACIVLSERCDGFLDCSDESDE 1546
EF+C +G CDG DC D+SDE
Sbjct: 2860 PSEFRCANGRCLSSRQWECDGENDCHDQSDE 2890
Score = 231 bits (589), Expect = 6e-60
Identities = 131/348 (37%), Positives = 167/348 (47%), Gaps = 50/348 (14%)
Query: 1059 DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICD 1118
DC G C +E TC Q+RC N C+ W CD+DNDCGD SDE +C C
Sbjct: 3519 DCGDGSDEPKEEC--DERTCEPYQFRCKNNRCVPGRWQCDYDNDCGDNSDEESCTPRPCS 3576
Query: 1119 LDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCD 1178
+++F C +G CI +KCD + DC D SDE C +C D++ C SG CI W CD
Sbjct: 3577 -ESEFSCA-NGRCIAGRWKCDGDHDCADGSDEKDCTP-RCDMDQFQCKSGHCIPLRWRCD 3633
Query: 1179 GDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEK- 1237
D DC D SDE C TC FQC N C P W CDG+ DC D SDE+P C +
Sbjct: 3634 ADADCMDGSDEEACGTGVRTCPLDEFQCNNTLCKPLAWKCDGEDDCGDNSDENPEECARF 3693
Query: 1238 ---KCNGFRCPNG-TCIPSSKHCDGLRDCSDGSDEQHCEPLCTHF------MDFVCKNRQ 1287
FRC N C+ + CDG +C DG+DE+ CEP H +F+C+N Q
Sbjct: 3694 VCPPNRPFRCKNDRVCLWIGRQCDGTDNCGDGTDEEDCEPPTAHTTHCKDKKEFLCRN-Q 3752
Query: 1288 QCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGM 1347
+CL S+ C+ C DGSDE+ CS DP+ C I
Sbjct: 3753 RCLSSSLRCNMFDDCGDGSDEE----DCSIDPKL--------TSCATNASI--------- 3791
Query: 1348 DDCGDYSDEANCENPTEAPNCSRYFQFRCENG-HCIPNRWKCDRENDC 1394
CG DEA C +A C+ C +G H +P + C N+C
Sbjct: 3792 --CG---DEARCVRTEKAAYCA------CRSGFHTVPGQPGCQDINEC 3828
Score = 176 bits (447), Expect = 2e-43
Identities = 106/294 (36%), Positives = 163/294 (55%), Gaps = 14/294 (4%)
Query: 760 FILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCL 817
F+LY+V + I L +P++G AV +DF E++ +YW D+ L I R
Sbjct: 1892 FLLYSVHEGIRGIPLDPNDKSDALVPVSGTSLAVGIDFHAENDTIYWVDMGLSTISR-AK 1950
Query: 818 NGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDR 877
T +E ++ +G+ VE +A + ++ +YW D GF IEVA +G FR ++ S LD+
Sbjct: 1951 RDQTWREDVVTNGIGRVEGIAVDWIAGNIYWTDQGFDVIEVARLNGSFRYVVI-SQGLDK 2009
Query: 878 PRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYW 935
PRA+ + P++G +FWT+WG P I RS +DG+ LV+ + WPNGISVD D +YW
Sbjct: 2010 PRAITVHPEKGYLFWTEWGQY-PRIERSRLDGTERVVLVNVSISWPNGISVDYQDGKLYW 2068
Query: 936 TDAYLECIERITF-SGQQRSVIL-DNLPHPYAIAVFKNEIYWDDWSQL--SIFRASKYSG 991
DA + IERI +G+ R V+L N ++++VF++ IYW D + SI R SK +
Sbjct: 2069 CDARTDKIERIDLETGENREVVLSSNNMDMFSVSVFEDFIYWSDRTHANGSIKRGSKDNA 2128
Query: 992 SQMEILANQL-TGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRC 1042
+ L + L D+K+F + + G+N C C LCL + R+C C
Sbjct: 2129 TDSVPLRTGIGVQLKDIKVFNRDRQKGTNVCAVANGGCQQLCLYRGRGQRACAC 2182
Score = 176 bits (445), Expect = 3e-43
Identities = 103/299 (34%), Positives = 162/299 (54%), Gaps = 17/299 (5%)
Query: 760 FILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR--LCL 817
FI+++ R I R DL G L + GLR +ALDF + LYW+D+ D I R L
Sbjct: 1270 FIIFSNRHEIRRIDLHKGDYSVL-VPGLRNTIALDFHLSQSALYWTDVVEDKIYRGKLLD 1328
Query: 818 NGS-TGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876
NG+ T EV+I GL T E LA + ++ +YWV++ +IEVA DG R T++ + +
Sbjct: 1329 NGALTSFEVVIQYGLATPEGLAVDWIAGNIYWVESNLDQIEVAKLDGTLRTTLLAGDI-E 1387
Query: 877 RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSA--AYHLVSEDVKWPNGISVD--DQW 932
PRA+ L P++G++FWTDW P I ++M G+ H + WPNG++VD ++
Sbjct: 1388 HPRAIALDPRDGILFWTDWDASLPRIEAASMSGAGRRTVHRETGSGGWPNGLTVDYLEKR 1447
Query: 933 IYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRASKY 989
I W DA + I + G +L + L HP+A+ ++ E+YW DW ++ +A+K+
Sbjct: 1448 ILWIDARSDAIYSARYDGSGHMEVLRGHEFLSHPFAVTLYGGEVYWTDWRTNTLAKANKW 1507
Query: 990 SGSQMEILANQLTGLMDMKIFYKGKN-TGSNACVPR----PCSLLCLPKANNSRSCRCP 1043
+G + ++ T D+++++ + N C PCS LCL N + SC CP
Sbjct: 1508 TGHNVTVVQRTNTQPFDLQVYHPSRQPMAPNPCEANGGQGPCSHLCLINYNRTVSCACP 1566
Score = 149 bits (377), Expect = 2e-35
Identities = 137/503 (27%), Positives = 211/503 (41%), Gaps = 104/503 (20%)
Query: 829 SGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEG 888
SGL+ +A + ++ +YW D+G IEVA G+ R T++ S ++D P A+V+ P G
Sbjct: 3955 SGLKMPRGIAIDWVAGNVYWTDSGRDVIEVAQMKGENRKTLI-SGMIDEPHAIVVDPLRG 4013
Query: 889 VMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERI 946
M+W+DWG+ P I + MDG+ LV ++++WP G++VD ++ +YW DA L I I
Sbjct: 4014 TMYWSDWGN-HPKIETAAMDGTLRETLVQDNIQWPTGLAVDYHNERLYWADAKLSVIGSI 4072
Query: 947 TFSGQQRSVILDN---LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTG 1003
+G V D+ L HP++I VF++ IY + +F+ K+ S + L L+
Sbjct: 4073 RLNGTDPIVAADSKRGLSHPFSIDVFEDYIYGVTYINNRVFKIHKFGHSPLVNLTGGLSH 4132
Query: 1004 LMDMKIFYKGKNTG-SNACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQ 1062
D+ ++++ K +N C + C LCL + PSG + C CP
Sbjct: 4133 ASDVVLYHQHKQPEVTNPCDRKKCEWLCL------------------LSPSGPV-CTCPN 4173
Query: 1063 GYQLKNNTCVK-----------EENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERN 1111
G +L N TCV TC +C NG F N +
Sbjct: 4174 GKRLDNGTCVPVPSPTPPPDAPRPGTC---NLQCFNGGSC-------FLN--ARRQPKCR 4221
Query: 1112 CPTTI----CDLDTQFR-CQESGTCI-----------PLSY---KCDLEDDCGDNSDESH 1152
C C+LD + C+ GTC P + KC + G ++ S
Sbjct: 4222 CQPRYTGDKCELDQCWEHCRNGGTCAASPSGMPTCRCPTGFTGPKCTQQVCAGYCANNST 4281
Query: 1153 CEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRN-GHC 1211
C ++Q + C G GD C+ Y C C N G C
Sbjct: 4282 CTVNQGNQPQCRCLPGFL--------GDR-CQ-----------YRQCSG---YCENFGTC 4318
Query: 1212 IPQRWACDGDTDCQDGSDEDPVNCE-KKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQH 1270
+ A DG C+ + + CE KC+ RC G C+ + + D +C+DG
Sbjct: 4319 ---QMAADGSRQCRCTAYFEGSRCEVNKCS--RCLEGACVVNKQSGDVTCNCTDGRVAPS 4373
Query: 1271 CEPLCTHFMDFVCKNRQQCLFHS 1293
C H C N C +S
Sbjct: 4374 CLTCVGH-----CSNGGSCTMNS 4391
Score = 130 bits (326), Expect = 2e-29
Identities = 100/319 (31%), Positives = 152/319 (47%), Gaps = 26/319 (8%)
Query: 756 EENEFILYAVRKSIYRYDLASGATEQL---PLTGLRAAVALDFDYEHNCLYWSDLALDVI 812
E +F+LYA + I DL + + + + LD+D +YWSD+ I
Sbjct: 1580 EFKKFLLYARQMEIRGVDLDAPYYNYIISFTVPDIDNVTVLDYDAREQRVYWSDVRTQAI 1639
Query: 813 QRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWV--DAGFKKIEVANPDGDFRLTIV 870
+R +NG TG E ++++ L LA + +S+ L+W D K+I VA DG F+ +V
Sbjct: 1640 KRAFING-TGVETVVSADLPNAHGLAVDWVSRNLFWTSYDTNKKQINVARLDGSFKNAVV 1698
Query: 871 NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD- 929
L++P LV+ P G ++WTD GD I +NMDGS L S K P G+++D
Sbjct: 1699 QG--LEQPHGLVVHPLRGKLYWTD-GD---NISMANMDGSNRTLLFSGQ-KGPVGLAIDF 1751
Query: 930 -DQWIYWTDAYLECIERITFSGQQRSVI---LDNLPHPYAIAVFKNEIYWDDWSQLSIFR 985
+ +YW + I R G VI L A+A+ ++++W D +
Sbjct: 1752 PESKLYWISSGNHTINRCNLDGSGLEVIDAMRSQLGKATALAIMGDKLWWADQVSEKMGT 1811
Query: 986 ASKYSGSQMEILANQLTGLMDMKIFYKG---KNTGSNACVPR--PCSLLCLPKANNSRSC 1040
SK GS +L N T +M MK++ + + G+N C CS LCLP + +RSC
Sbjct: 1812 CSKADGSGSVVLRNSTTLVMHMKVYDESIQLDHKGTNPCSVNNGDCSQLCLPTSETTRSC 1871
Query: 1041 RCPEDVSSSVLPSGDLMCD 1059
C S L SG C+
Sbjct: 1872 MCTAGYS---LRSGQQACE 1887
Score = 128 bits (321), Expect = 7e-29
Identities = 84/249 (33%), Positives = 113/249 (45%), Gaps = 28/249 (11%)
Query: 1330 FQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCD 1389
F+C NG CI+ CDG+ C D SDE + + C + F+ +C NG C+ N C+
Sbjct: 2530 FECANGECINFSLTCDGVPHCKDKSDEK--PSYCNSRRCKKTFR-QCSNGRCVSNMLWCN 2586
Query: 1390 RENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSD 1449
+DCGD SDE C + C +RC GTC+ ++ C+ + DC D SD
Sbjct: 2587 GADDCGDGSDEIPCNKT-----------ACGVGEFRCRDGTCIGNSSRCNQFVDCEDASD 2635
Query: 1450 EEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCI-PNWKRCDGHQDCQDGRDEANCPT 1508
E C + T S+ +LG C + C P+W CDG DC D DE +CP
Sbjct: 2636 EMNC----SATDCSSYFRLGVKGVLFQPCERTSLCYAPSWV-CDGANDCGDYSDERDCPG 2690
Query: 1509 HSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDE----KACSD---ELTVYKVQNL 1561
C F C G CI +S CD DC DE K CS+ E ++ +
Sbjct: 2691 VKRPRCPLNYFACPSGR-CIPMSWTCDKEDDCEHGEDETHCNKFCSEAQFECQNHRCISK 2749
Query: 1562 QWTADFSGD 1570
QW D S D
Sbjct: 2750 QWLCDGSDD 2758
Score = 112 bits (280), Expect = 4e-24
Identities = 85/256 (33%), Positives = 110/256 (42%), Gaps = 46/256 (17%)
Query: 1334 NGVCISLIWKCDGMDDCGDYSDEA------NC-ENPTEAP--NCSRYFQFRCENGHCIPN 1384
NG C SL G C D+ C NP+ P C +F C N CI
Sbjct: 811 NGGCSSLCLATPGSRQCACAEDQVLDADGVTCLANPSYVPPPQCQPG-EFACANSRCIQE 869
Query: 1385 RWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDC 1444
RWKCD +NDC D SDE + TC + ++C + C+ + W+CDG DC
Sbjct: 870 RWKCDGDNDCLDNSDEAP---------ALCHQHTCPSDRFKCENNRCIPNRWLCDGDNDC 920
Query: 1445 ADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDE- 1503
+ DE +N T ++ C +F C + CIP CD DC D DE
Sbjct: 921 GNSEDE------SNATCSART-----CPPNQFSCASGR-CIPISWTCDLDDDCGDRSDES 968
Query: 1504 ANC--PTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDEL--TVYKVQ 1559
A+C PT LT +F C +G CI ++ RCD DC D SDE CS T +K
Sbjct: 969 ASCAYPTCFPLT----QFTCNNGR-CININWRCDNDNDCGDNSDEAGCSHSCSSTQFKCN 1023
Query: 1560 N-----LQWTADFSGD 1570
+ WT D D
Sbjct: 1024 SGRCIPEHWTCDGDND 1039
Score = 108 bits (269), Expect = 8e-23
Identities = 86/328 (26%), Positives = 155/328 (47%), Gaps = 31/328 (9%)
Query: 761 ILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLC---- 816
+L A ++I L+ + T R A+DF Y + + W + Q
Sbjct: 201 LLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCAR 260
Query: 817 ---LNGSTGQEVI-INSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNS 872
L G + I I+ L VE +A + L+ Y+VD +I V N +GD +T+++
Sbjct: 261 MPGLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDL 320
Query: 873 SVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--D 930
+ + P+ + L P G +F+TD+G + P + R +MDG LV + +P+GI++D
Sbjct: 321 ELYN-PKGIALDPAMGKVFFTDYGQI-PKVERCDMDGQNRTKLVDSKIVFPHGITLDLVS 378
Query: 931 QWIYWTDAYLECIERITFSGQQRSVILDN--LPHPYAIAVFKNEIYWDD------WSQLS 982
+ +YW DAYL+ IE + + G+ R I+ + H Y + VF+N +Y + + S
Sbjct: 379 RLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTS 438
Query: 983 IFRASKYSGSQMEILAN-QLTGLMDMKIFYKGKNTGSNAC------VPRPCSLLC-LPKA 1034
+ R ++++ ++ +++ G + + + S+AC P CS +C L +
Sbjct: 439 VIRVNRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANS 498
Query: 1035 NNSRSCRCPEDVSSSVLPSGDLMCDCPQ 1062
+ +R+CRC S L S C P+
Sbjct: 499 HKARTCRCRSGFS---LGSDGKSCKKPE 523
Score = 101 bits (251), Expect = 9e-21
Identities = 69/189 (36%), Positives = 81/189 (42%), Gaps = 29/189 (15%)
Query: 1367 NCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRC 1426
+C +F C NG CI CD C D SDEK S C + +C
Sbjct: 2523 SCRAQDEFECANGECINFSLTCDGVPHCKDKSDEKP---------SYCNSRRCKKTFRQC 2573
Query: 1427 SSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIP 1486
S+G CV + C+G DC DGSDE C N TA C EF C TCI
Sbjct: 2574 SNGRCVSNMLWCNGADDCGDGSDEIPC----NKTA---------CGVGEFRCRDG-TCIG 2619
Query: 1487 NWKRCDGHQDCQDGRDEANCP-----THSTLTCMSREFQ-CEDGEACIVLSERCDGFLDC 1540
N RC+ DC+D DE NC ++ L FQ CE C S CDG DC
Sbjct: 2620 NSSRCNQFVDCEDASDEMNCSATDCSSYFRLGVKGVLFQPCERTSLCYAPSWVCDGANDC 2679
Query: 1541 SDESDEKAC 1549
D SDE+ C
Sbjct: 2680 GDYSDERDC 2688
Score = 77.4 bits (189), Expect = 1e-13
Identities = 54/164 (32%), Positives = 69/164 (42%), Gaps = 33/164 (20%)
Query: 1406 SHILPFSTPGPSTCLPNYYRCSSG-TCVMDTWVCDGYRDCADGSDE--EACPLLANVTAA 1462
S ++ + P TC P + C TC+ W CDG RDC DGSDE E CP
Sbjct: 14 SALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICP-------- 65
Query: 1463 STPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDE--------ANCPTHSTLTC 1514
++ RC E C + C+P + C+G QDC DG DE NC S L C
Sbjct: 66 --QSKAQRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNC---SRLGC 120
Query: 1515 MSREFQCEDGEACIVLSERCDGFLDCSDESDEKACS--DELTVY 1556
DG C C+ ++D K C DE +VY
Sbjct: 121 QHHCVPTLDGPTCY-----CNSSFQL--QADGKTCKDFDECSVY 157
Score = 76.3 bits (186), Expect = 3e-13
Identities = 56/165 (33%), Positives = 70/165 (42%), Gaps = 27/165 (16%)
Query: 1198 TCEASNFQCRNG-HCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRC-PN-----GT-- 1248
TC F CR+ CI + W CDG+ DC DGSDE P C + RC PN GT
Sbjct: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQS-KAQRCQPNEHNCLGTEL 84
Query: 1249 CIPSSKHCDGLRDCSDGSDE-QHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
C+P S+ C+G++DC DGSDE HC L + C++ C D
Sbjct: 85 CVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQH---------------HCVPTLD 129
Query: 1308 EDAAFAGCS-QDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCG 1351
+ S Q K C +F G C L DG CG
Sbjct: 130 GPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFICG 174
Score = 72.4 bits (176), Expect = 5e-12
Identities = 38/95 (40%), Positives = 46/95 (48%), Gaps = 3/95 (3%)
Query: 1454 PLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEAN--CPTHST 1511
PLL+ + AA+ C +F C TCI RCDG +DC DG DEA CP
Sbjct: 11 PLLSALVAAAIDAPK-TCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKA 69
Query: 1512 LTCMSREFQCEDGEACIVLSERCDGFLDCSDESDE 1546
C E C E C+ +S C+G DC D SDE
Sbjct: 70 QRCQPNEHNCLGTELCVPMSRLCNGVQDCMDGSDE 104
Score = 72.4 bits (176), Expect = 5e-12
Identities = 51/150 (34%), Positives = 72/150 (48%), Gaps = 16/150 (10%)
Query: 1122 QFRCQESGTCIPLSYKCDLEDDCGDNSDES-----HCEMHQCRSDEYNC-SSGMCIRSSW 1175
QF C++ TCI ++CD E DC D SDE+ + +C+ +E+NC + +C+ S
Sbjct: 31 QFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTELCVPMSR 90
Query: 1176 VCDGDNDCRDWSDEA-NCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVN 1234
+C+G DC D SDE +C + C S C++ HC+P DG T C S
Sbjct: 91 LCNGVQDCMDGSDEGPHCRELQGNC--SRLGCQH-HCVP---TLDGPT-CYCNSSFQLQA 143
Query: 1235 CEKKCNGF-RCP-NGTCIPSSKHCDGLRDC 1262
K C F C GTC + DG C
Sbjct: 144 DGKTCKDFDECSVYGTCSQLCTNTDGSFIC 173
Score = 56.2 bits (134), Expect = 3e-07
Identities = 38/102 (37%), Positives = 47/102 (46%), Gaps = 15/102 (14%)
Query: 1077 TCLRNQYRCSNG-NCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQES-----GT 1130
TC Q+ C + CI+ W CD + DC D SDE IC RCQ + GT
Sbjct: 26 TCSPKQFACRDQITCISKGWRCDGERDCPDGSDE---APEICPQSKAQRCQPNEHNCLGT 82
Query: 1131 --CIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMC 1170
C+P+S C+ DC D SDE CR + NCS C
Sbjct: 83 ELCVPMSRLCNGVQDCMDGSDEG----PHCRELQGNCSRLGC 120
Score = 54.3 bits (129), Expect = 1e-06
Identities = 38/138 (27%), Positives = 58/138 (42%), Gaps = 18/138 (13%)
Query: 1067 KNNTCVKEENTC-LRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRC 1125
KN C +E+ C +Q+ CS+G C+ C+ +DCGD SDER C C C
Sbjct: 2893 KNPHCTSQEHKCNASSQFLCSSGRCVAEALLCNGQDDCGDSSDERGCHINECLSRKLSGC 2952
Query: 1126 QESGTCIPLSYKC------DLEDDCGDNSDESHCE-----MHQC--RSDEYNCSSGMCIR 1172
+ + + +KC L+DD +D C +C Y C +C+
Sbjct: 2953 SQDCEDLKIGFKCRCRPGFRLKDDGRTCADVDECSTTFPCSQRCINTHGSYKC---LCVE 3009
Query: 1173 SSWVCDGD-NDCRDWSDE 1189
GD + C+ +DE
Sbjct: 3010 GYAPRGGDPHSCKAVTDE 3027
Score = 48.1 bits (113), Expect = 9e-05
Identities = 30/80 (37%), Positives = 38/80 (47%), Gaps = 2/80 (2%)
Query: 1323 KVCDEFGFQCQNGV-CISLIWKCDGMDDCGDYSDEANCENP-TEAPNCSRYFQFRCENGH 1380
K C F C++ + CIS W+CDG DC D SDEA P ++A C
Sbjct: 25 KTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGTEL 84
Query: 1381 CIPNRWKCDRENDCGDWSDE 1400
C+P C+ DC D SDE
Sbjct: 85 CVPMSRLCNGVQDCMDGSDE 104
Score = 37.0 bits (84), Expect = 0.22
Identities = 46/197 (23%), Positives = 76/197 (38%), Gaps = 41/197 (20%)
Query: 1343 KCDGMDDCGDYSDEAN--CENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
KC+ +D C ++ +P+ P C RC G P KC ++ G ++
Sbjct: 4230 KCE-LDQCWEHCRNGGTCAASPSGMPTC------RCPTGFTGP---KCTQQVCAGYCANN 4279
Query: 1401 KDCGDSHILPFSTPGPSTCLPNYY--RCSSGTCVMDTWVCDGYRDC---ADGSDEEACPL 1455
C + CLP + RC C + C+ + C ADGS + C
Sbjct: 4280 STCTVNQ----GNQPQCRCLPGFLGDRCQYRQC---SGYCENFGTCQMAADGSRQCRCTA 4332
Query: 1456 LANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCM 1515
+ ++ +C R C + C+ N + D +C DGR +C LTC+
Sbjct: 4333 YFE----GSRCEVNKCSR----CLEG-ACVVNKQSGDVTCNCTDGRVAPSC-----LTCV 4378
Query: 1516 SREFQCEDGEACIVLSE 1532
C +G +C + S+
Sbjct: 4379 G---HCSNGGSCTMNSK 4392
Score = 35.4 bits (80), Expect = 0.63
Identities = 29/120 (24%), Positives = 51/120 (42%), Gaps = 3/120 (2%)
Query: 768 SIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVII 827
SI R L+ L +R L D+ LY+SD LD I+R +GS + VI+
Sbjct: 2357 SIMRAALSGANVLTLIEKDIRTPNGLAIDHRAEKLYFSDATLDKIERCEYDGS-HRYVIL 2415
Query: 828 NSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQE 887
S E V + ++W D + ++ AN + ++ + +P ++ V +
Sbjct: 2416 KS--EPVHPFGLAVYGEHIFWTDWVRRAVQRANKHVGSNMKLLRVDIPQQPMGIIAVAND 2473
>gi|126012573 low density lipoprotein-related protein 2 [Homo sapiens]
Length = 4655
Score = 479 bits (1233), Expect = e-134
Identities = 325/911 (35%), Positives = 425/911 (46%), Gaps = 106/911 (11%)
Query: 674 NCSCTREDYECDF--GFKMSEDLSLEVCVPDPEFSGKSYSPPVPCP--VGSTYRRTR-GY 728
NC+ T + C G+K+ D CV E + + C +GS + GY
Sbjct: 3125 NCTDTLTSFYCSCRPGYKLMSDK--RTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGY 3182
Query: 729 -RKISGDTCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGL 787
R+ G TC R + P L N + L + Y Y L L GL
Sbjct: 3183 LREPDGKTC-------RQNSNIEPY-LIFSNRYYLRNLTIDGYFYSLI--------LEGL 3226
Query: 788 RAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLY 847
VALDFD LYW D VI+R+ LN T +E IIN L E+LA + +S+ LY
Sbjct: 3227 DNVVALDFDRVEKRLYWIDTQRQVIERMFLN-KTNKETIINHRLPAAESLAVDWVSRKLY 3285
Query: 848 WVDAGFKKIEVANPDGDFRLTIV-------NSSVLDRPRALVLVPQEGVMFWTDWGDLKP 900
W+DA + V++ +G R + N+ D PR L L PQ G ++W DWG +
Sbjct: 3286 WLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGH-RA 3344
Query: 901 GIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILD 958
I R MDG+ ++S ++WPNGI++D + +YW DA+L IE G R + D
Sbjct: 3345 YIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYD 3404
Query: 959 N-LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNT- 1016
LPHP+AI +F++ IYW DW+ ++ + +KY GS + L N D+ +++ +
Sbjct: 3405 GALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPI 3464
Query: 1017 GSNACVPRP--CSLLCLPKANNSR-SCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVK 1073
SN C CS LCL K +C CP+D + L SG C
Sbjct: 3465 VSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQL-SGSTYC--------------- 3508
Query: 1074 EENTCLRNQYRCSNGNCINSIWW-CDFDNDCGDMSDERN-CPTTICDLDTQFRCQESGTC 1131
C Q+ C+N IWW CD DC D SDE CP C L QF+C + G C
Sbjct: 3509 -MPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLG-QFQCSD-GNC 3565
Query: 1132 IPLSYKCDLEDDCGDNSDESH--CEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
C+ +C D SDE CE H C S+E+ C++ CI SW CD NDC D SDE
Sbjct: 3566 TSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDE 3625
Query: 1190 ANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCN------GFR 1243
+ TC F+C NG CIPQ W CD D DC D SDE C + F
Sbjct: 3626 DSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFS 3685
Query: 1244 C-PNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFM-DFVCKNRQQCLFHSMVCDGIIQ 1301
C N CIP C+G+ DC D SDEQ CE H + DF CKN C+ CDG
Sbjct: 3686 CKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKN-HHCIPLRWQCDGQND 3744
Query: 1302 CRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCEN 1361
C D SDE+ C+ + C E F+C N CI W CD +DCGD SDE +CE
Sbjct: 3745 CGDNSDEE----NCAP-----RECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEM 3795
Query: 1362 PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLP 1421
T P YFQ C +GHC+ + KCD DC D SDE DC P P + C
Sbjct: 3796 RTCHP---EYFQ--CTSGHCVHSELKCDGSADCLDASDEADC------PTRFPDGAYCQA 3844
Query: 1422 NYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQP 1481
+ C + C+ W CDG DC DGSDEE L ++P + RCD
Sbjct: 3845 TMFECKNHVCIPPYWKCDGDDDCGDGSDEEL--HLCLDVPCNSPNRF-RCDN-------- 3893
Query: 1482 KTCIPNWKRCDGHQDCQDGRDEA--NCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLD 1539
CI + + C+G DC DG DE +C + C E++C +G CI CD D
Sbjct: 3894 NRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGH-CIPHDNVCDDADD 3952
Query: 1540 CSDESDEKACS 1550
C D SDE C+
Sbjct: 3953 CGDWSDELGCN 3963
Score = 418 bits (1074), Expect = e-116
Identities = 276/846 (32%), Positives = 407/846 (48%), Gaps = 115/846 (13%)
Query: 752 CPLAEENEFILYAVRKSI--YRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWS-DLA 808
C ++ EN F+++A+ S+ D + + + R ++LD+D + +Y++ +LA
Sbjct: 2382 CAISTEN-FLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLA 2440
Query: 809 LDV--IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFR 866
V I L+ +I SG+ T + +AF+ +++ +Y+ D + I DG R
Sbjct: 2441 SGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNR 2500
Query: 867 LTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGI 926
I + +PRA+VL P +G ++W DW D I R+ + G+ +V+ + P+G+
Sbjct: 2501 TVIAR---VPKPRAIVLDPCQGYLYWADW-DTHAKIERATLGGNFRVPIVNSSLVMPSGL 2556
Query: 927 SVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIF 984
++D + +YW DA L+ IER T +G R VI++ H + + ++ IYW D I+
Sbjct: 2557 TLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIY 2616
Query: 985 RASKYSGS-QMEILANQLTGLMDMKIFYKG-KNTGSNAC--VPRPCSLLCLPKANNSRSC 1040
RA+KY GS Q+ + N L+ + K K +N C CS +C P N + C
Sbjct: 2617 RANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGA-EC 2675
Query: 1041 RCPEDVSSSVLPSGDLMCDCPQG-------YQLKNNTCVKEE------------------ 1075
+CP + + L + C G + N C+ EE
Sbjct: 2676 QCPHE-GNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMES 2734
Query: 1076 ----NTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTC 1131
+TC + C+NG C+ + CD+ NDCGD SDE C C+ T+F C + C
Sbjct: 2735 VCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMC-NNRRC 2793
Query: 1132 IPLSYKCDLEDDCGDN--SDESHCEMHQCRSDEYNC-SSGMCIRSSWVCDGDNDCRDWSD 1188
IP + C+ D+C DN SDE +C C+S C +S +CI ++CDGDNDC D SD
Sbjct: 2794 IPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSD 2853
Query: 1189 EANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC---EKKC--NGFR 1243
E HTC +S FQC +G CIPQ W CD +TDC D SDE P +C E+ C + F+
Sbjct: 2854 ENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDE-PASCGHSERTCLADEFK 2912
Query: 1244 CPNGTCIPSSKHCDGLRDCSDGSDE---QHCEPLCTHFMDFVCKN----RQQCLFHSMVC 1296
C G CIPS CDG DC D SDE C+ +F+C N ++C+ S VC
Sbjct: 2913 CDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVC 2972
Query: 1297 DGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
DG + C DG DE+ C++ + C E F C G+CI I++CD +DCGDYSDE
Sbjct: 2973 DGDVDCTDGYDEN---QNCTR-----RTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDE 3024
Query: 1357 ANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGP 1416
C T N QF C+NG CI + CD +NDCGD SDE H+ TP P
Sbjct: 3025 RGCLYQTCQQN-----QFTCQNGRCISKTFVCDEDNDCGDGSDEL----MHLC--HTPEP 3073
Query: 1417 STCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEF 1476
TC P+ ++C +G C+ +C+ DC D SDE+ C +
Sbjct: 3074 -TCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGI--------------------N 3112
Query: 1477 ECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEAC----IVLSE 1532
ECH P CD +C D C MS + C D + C V S+
Sbjct: 3113 ECHDPSI-----SGCD--HNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQ 3165
Query: 1533 RCDGFL 1538
+C+ +
Sbjct: 3166 KCENVI 3171
Score = 337 bits (865), Expect = 6e-92
Identities = 214/621 (34%), Positives = 318/621 (51%), Gaps = 73/621 (11%)
Query: 791 VALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVD 850
V +DFD + + +++SD++ +I + ++G TG+E++ + +E VE+LAF+ +S+ LYW D
Sbjct: 744 VGIDFDAQDSTIFFSDMSKHMIFKQKIDG-TGREILAANRVENVESLAFDWISKNLYWTD 802
Query: 851 AGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPG-IYRSNMDG 909
+ +K I V R T+V L+ PR++V+ P G +F+TDW +P I R+ DG
Sbjct: 803 SHYKSISVMRLADKTRRTVVQ--YLNNPRSVVVHPFAGYLFFTDW--FRPAKIMRAWSDG 858
Query: 910 SAAYHLVSEDVKWPNGISVDDQW----IYWTDAYLECIERITFSGQQRSVI--LDNLPHP 963
S +++ + WPNG+++D W +YW DAY + IE TF G R + ++ + HP
Sbjct: 859 SHLLPVINTTLGWPNGLAID--WAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHP 916
Query: 964 YAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVP 1023
+ +A+F +++ DW +I R K G +M ++ + + ++ +K + TGSNAC
Sbjct: 917 FGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQ 976
Query: 1024 RP-----CSLLCLPKANNSRSCRCPEDV---SSSVLPSGDLMCDCPQ------GYQLKNN 1069
CS C P N R C CP + S+ + GD + P + KN
Sbjct: 977 PTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNG 1036
Query: 1070 TCVKE----------------------ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMS 1107
CV NTC + + C +G CI + W CD NDC D S
Sbjct: 1037 RCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGS 1096
Query: 1108 DERNCPT--TICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQ-CRSDEYN 1164
DE NCPT LDTQ+ C ++ CI ++ CD ++DCGD SDE +C + C+ ++N
Sbjct: 1097 DEHNCPTHAPASCLDTQYTC-DNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFN 1155
Query: 1165 CSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNG-HCIPQRWACDGDTD 1223
C + CI S+VCDGD DC D SDE C C AS F+C +G CI CDG D
Sbjct: 1156 CPNHRCIDLSFVCDGDKDCVDGSDEVGCVL---NCTASQFKCASGDKCIGVTNRCDGVFD 1212
Query: 1224 CQDGSDED--PVNCEKKCNG--FRC-PNGTCIPSSKHCDGLRDCSDGSDEQH-CEPLCTH 1277
C D SDE P C+ F+C +G CIP+ CDG DC GSDE + C P
Sbjct: 1213 CSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCP 1272
Query: 1278 FMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQC-QNGV 1336
F C N C+ + +CD C D SDE C P F C + +QC + +
Sbjct: 1273 SSYFHCDN-GNCIHRAWLCDRDNDCGDMSDE----KDCPTQP-FR--CPSWQWQCLGHNI 1324
Query: 1337 CISLIWKCDGMDDCGDYSDEA 1357
C++L CDG+ DC + +DE+
Sbjct: 1325 CVNLSVVCDGIFDCPNGTDES 1345
Score = 296 bits (759), Expect = 1e-79
Identities = 207/654 (31%), Positives = 288/654 (44%), Gaps = 96/654 (14%)
Query: 769 IYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIIN 828
I++ + E L + +L FD+ LYW+D I + L T + V+
Sbjct: 765 IFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVV-- 822
Query: 829 SGLETVEALAFEPLSQLLYWVDAGFK--KIEVANPDGDFRLTIVNSSVLDRPRALVLVPQ 886
L ++ P + L++ D F+ KI A DG L ++N++ L P L +
Sbjct: 823 QYLNNPRSVVVHPFAGYLFFTD-WFRPAKIMRAWSDGSHLLPVINTT-LGWPNGLAIDWA 880
Query: 887 EGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQWIYWTDAYLECIERI 946
++W D AY + IE
Sbjct: 881 ASRLYWVD-------------------------------------------AYFDKIEHS 897
Query: 947 TFSGQQRSVI--LDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGL 1004
TF G R + ++ + HP+ +A+F +++ DW +I R K G +M ++ + + +
Sbjct: 898 TFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYI 957
Query: 1005 MDMKIFYKGKNTGSNAC-----VPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCD 1059
+ +K + TGSNAC CS C P N R C CP + L S L C+
Sbjct: 958 LHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMR---LASNHLTCE 1014
Query: 1060 CPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPT--TIC 1117
+ T C + C NG C+ + + CD +DC D SDE+ C T C
Sbjct: 1015 -------GDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTC 1067
Query: 1118 DLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMH---QCRSDEYNCSSGMCIRSS 1174
+ F C G CIP ++CD +DC D SDE +C H C +Y C + CI +
Sbjct: 1068 S-SSAFTCGH-GECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKN 1125
Query: 1175 WVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVN 1234
WVCD DNDC D SDE NC + TC+ S F C N CI + CDGD DC DGSDE V
Sbjct: 1126 WVCDTDNDCGDGSDEKNCNST-ETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDE--VG 1182
Query: 1235 CEKKCNG--FRCPNG-TCIPSSKHCDGLRDCSDGSDEQHC---EPLCTHFMDFVCKNRQQ 1288
C C F+C +G CI + CDG+ DCSD SDE C P H +F C+
Sbjct: 1183 CVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGI 1242
Query: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
C+ + CDG C GSDE A K C F C NG CI W CD +
Sbjct: 1243 CIPNFWECDGHPDCLYGSDEHNACV--------PKTCPSSYFHCDNGNCIHRAWLCDRDN 1294
Query: 1349 DCGDYSDEANCENPTEAPNCSRYFQFRCENGH--CIPNRWKCDRENDCGDWSDE 1400
DCGD SDE +C PT+ C + Q++C GH C+ CD DC + +DE
Sbjct: 1295 DCGDMSDEKDC--PTQPFRCPSW-QWQC-LGHNICVNLSVVCDGIFDCPNGTDE 1344
Score = 233 bits (593), Expect = 2e-60
Identities = 133/363 (36%), Positives = 168/363 (46%), Gaps = 62/363 (17%)
Query: 1055 DLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE--RNC 1112
D DC ++ C TC Q+RC+NG CI W CD DNDCGD SDE C
Sbjct: 3614 DTFNDCEDNSDEDSSHCASR--TCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEEC 3671
Query: 1113 PTT--ICDLDTQFRCQ-----------------------ESGT----------------- 1130
++ +CD T+F C+ E G
Sbjct: 3672 MSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHH 3731
Query: 1131 CIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEA 1190
CIPL ++CD ++DCGDNSDE +C +C E+ C + CI S W+CD NDC D SDE
Sbjct: 3732 CIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDER 3791
Query: 1191 NCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDED------PVNCEKKCNGFRC 1244
+C TC FQC +GHC+ CDG DC D SDE P + F C
Sbjct: 3792 DCEM--RTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFEC 3849
Query: 1245 PNGTCIPSSKHCDGLRDCSDGSDEQH---CEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQ 1301
N CIP CDG DC DGSDE+ + C F C N + C++ VC+G+
Sbjct: 3850 KNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNR-CIYSHEVCNGVDD 3908
Query: 1302 CRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCEN 1361
C DG+DE C + K C E+ ++C NG CI CD DDCGD+SDE C
Sbjct: 3909 CGDGTDETEEH--CRKPTP--KPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNK 3964
Query: 1362 PTE 1364
E
Sbjct: 3965 GKE 3967
Score = 226 bits (575), Expect = 3e-58
Identities = 134/352 (38%), Positives = 167/352 (47%), Gaps = 68/352 (19%)
Query: 1145 GDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNF 1204
GD ++E E QC + C +G C+ + ++CDG +DC D SDE C + +TC +S F
Sbjct: 1015 GDPTNEPPTE--QCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAF 1072
Query: 1205 QCRNGHCIPQRWACDGDTDCQDGSDED------PVNC----------------------- 1235
C +G CIP W CD DC DGSDE P +C
Sbjct: 1073 TCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDN 1132
Query: 1236 -------EKKCNG--------FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMD 1280
EK CN F CPN CI S CDG +DC DGSDE C CT
Sbjct: 1133 DCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCT-ASQ 1191
Query: 1281 FVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQ-NGVCIS 1339
F C + +C+ + CDG+ C D SDE AGC P +C FQCQ +G+CI
Sbjct: 1192 FKCASGDKCIGVTNRCDGVFDCSDNSDE----AGCPTRPP--GMCHSDEFQCQEDGICIP 1245
Query: 1340 LIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSD 1399
W+CDG DC SDE N P P+ F C+NG+CI W CDR+NDCGD SD
Sbjct: 1246 NFWECDGHPDCLYGSDEHNACVPKTCPSS----YFHCDNGNCIHRAWLCDRDNDCGDMSD 1301
Query: 1400 EKDCGDSHILPFSTPGPSTCLPNYYRC-SSGTCVMDTWVCDGYRDCADGSDE 1450
EKDC P C ++C CV + VCDG DC +G+DE
Sbjct: 1302 EKDCPTQ---------PFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDE 1344
Score = 216 bits (550), Expect = 2e-55
Identities = 142/417 (34%), Positives = 181/417 (43%), Gaps = 78/417 (18%)
Query: 1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRN-GHCIPQR 1215
+C S + C SG CI + W CDG DC D +DE C + TC+ F+C++ G CIP
Sbjct: 27 ECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVV--TCQQGYFKCQSEGQCIPNS 84
Query: 1216 WACDGDTDCQDGSDEDPVNCEKKCNGFR--CPNGTCIPSSKHCDGLRDCSDGSDEQHCE- 1272
W CD D DC DGSDE + C+ + C NG CIPS CD +RDC DG+DE C+
Sbjct: 85 WVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQY 144
Query: 1273 PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQC 1332
P C C N C S CD + CRD SDE C++ +C F C
Sbjct: 145 PTCE---QLTCDN-GACYNTSQKCDWKVDCRDSSDE----INCTE------ICLHNEFSC 190
Query: 1333 QNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDREN 1392
NG CI + CD +DC D SDE C PT C Y QF C +G CI W CD E+
Sbjct: 191 GNGECIPRAYVCDHDNDCQDGSDEHACNYPT----CGGY-QFTCPSGRCIYQNWVCDGED 245
Query: 1393 DCGDWSDEKDCGDSHILPFSTPGP---STCLPNYYRC-SSGTCVMDTWVCDGYRDCADGS 1448
DC D DE C GP C P + C SG C+ VCDG DC
Sbjct: 246 DCKDNGDEDGC---------ESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGRE 296
Query: 1449 DEEACPLLANVTAASTPTQLGRCDRF--EFECHQ-------------------PKTCI-- 1485
DE N T+ + C +++CH+ +TC+
Sbjct: 297 DE-------NNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEF 349
Query: 1486 ---PNWKRCDGHQDCQDGRDEANCPTHSTLT----CMSREFQCEDGEACIVLSERCD 1535
W CD + + GR +C L C + + GEA I+ S D
Sbjct: 350 DDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKAND---SFGEASIIFSNGRD 403
Score = 215 bits (548), Expect = 3e-55
Identities = 117/286 (40%), Positives = 146/286 (51%), Gaps = 18/286 (6%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
C +RC +G+CI + W CD DC D +DE C C F+CQ G CIP S+
Sbjct: 28 CDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQ-QGYFKCQSEGQCIPNSWV 86
Query: 1138 CDLEDDCGDNSDE-SHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIY 1196
CD + DC D SDE C C S + CS+G CI S + CD DC D +DE +C Y
Sbjct: 87 CDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQ--Y 144
Query: 1197 HTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKC--NGFRCPNGTCIPSSK 1254
TCE C NG C CD DC+D SDE +NC + C N F C NG CIP +
Sbjct: 145 PTCE--QLTCDNGACYNTSQKCDWKVDCRDSSDE--INCTEICLHNEFSCGNGECIPRAY 200
Query: 1255 HCDGLRDCSDGSDEQHCE-PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFA 1313
CD DC DGSDE C P C + F C + +C++ + VCDG C+D DED
Sbjct: 201 VCDHDNDCQDGSDEHACNYPTCGGY-QFTCPS-GRCIYQNWVCDGEDDCKDNGDED---- 254
Query: 1314 GCSQDPEFHKVCDEFGFQC-QNGVCISLIWKCDGMDDCGDYSDEAN 1358
GC P C + C ++G CIS+ CDG+ DC DE N
Sbjct: 255 GCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENN 300
Score = 206 bits (523), Expect = 3e-52
Identities = 121/330 (36%), Positives = 157/330 (47%), Gaps = 51/330 (15%)
Query: 1242 FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQ 1301
FRC +G CIP+ CDG +DCSD +DE C + F C++ QC+ +S VCD
Sbjct: 33 FRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQD 92
Query: 1302 CRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCEN 1361
C DGSDE CSQ C C NG CI ++CD + DC D +DE +C+
Sbjct: 93 CDDGSDER---QDCSQ-----STCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQY 144
Query: 1362 PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLP 1421
PT C Q C+NG C KCD + DC D SDE +C + CL
Sbjct: 145 PT----CE---QLTCDNGACYNTSQKCDWKVDCRDSSDEINCTE------------ICLH 185
Query: 1422 NYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQP 1481
N + C +G C+ +VCD DC DGSDE AC + PT C ++F C
Sbjct: 186 NEFSCGNGECIPRAYVCDHDNDCQDGSDEHAC---------NYPT----CGGYQFTCPSG 232
Query: 1482 KTCIPNWKRCDGHQDCQDGRDEANCPT--HSTLTCMSREFQCEDGEACIVLSERCDGFLD 1539
+ NW CDG DC+D DE C + H C RE+ C + CI + + CDG LD
Sbjct: 233 RCIYQNWV-CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILD 291
Query: 1540 CSDESDE------KACSDELTVYKVQNLQW 1563
C DE K CS +T+ N Q+
Sbjct: 292 CPGREDENNTSTGKYCS--MTLCSALNCQY 319
Score = 199 bits (507), Expect = 2e-50
Identities = 119/318 (37%), Positives = 151/318 (47%), Gaps = 46/318 (14%)
Query: 1234 NCEKKCNGFRCPNGTCIPSSK-HCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFH 1292
N ++ C CP G + S+ C+G D ++E E C F F CKN + C+ +
Sbjct: 993 NFQRVCG---CPYGMRLASNHLTCEG-----DPTNEPPTEQ-CGLF-SFPCKNGR-CVPN 1041
Query: 1293 SMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGD 1352
+CDG+ C D SDE + C F C +G CI W+CD +DC D
Sbjct: 1042 YYLCDGVDDCHDNSDEQLCGT-------LNNTCSSSAFTCGHGECIPAHWRCDKRNDCVD 1094
Query: 1353 YSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFS 1412
SDE NC PT AP Q+ C+N CI W CD +NDCGD SDEK+C +
Sbjct: 1095 GSDEHNC--PTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTE----- 1147
Query: 1413 TPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCD 1472
TC P+ + C + C+ ++VCDG +DC DGSDE C L C
Sbjct: 1148 -----TCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVL--------------NCT 1188
Query: 1473 RFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSE 1532
+F+C CI RCDG DC D DEA CPT C S EFQC++ CI
Sbjct: 1189 ASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFW 1248
Query: 1533 RCDGFLDCSDESDE-KAC 1549
CDG DC SDE AC
Sbjct: 1249 ECDGHPDCLYGSDEHNAC 1266
Score = 169 bits (429), Expect = 2e-41
Identities = 108/318 (33%), Positives = 148/318 (46%), Gaps = 36/318 (11%)
Query: 1059 DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICD 1118
DC G + + ++TC +Q CSNG CI S + CD DC D +DE +C C+
Sbjct: 92 DCDDGSDERQDC---SQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCE 148
Query: 1119 LDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCD 1178
Q C ++G C S KCD + DC D+SDE +C C +E++C +G CI ++VCD
Sbjct: 149 ---QLTC-DNGACYNTSQKCDWKVDCRDSSDEINC-TEICLHNEFSCGNGECIPRAYVCD 203
Query: 1179 GDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEK- 1237
DNDC+D SDE C Y TC F C +G CI Q W CDG+ DC+D DED CE
Sbjct: 204 HDNDCQDGSDEHACN--YPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDED--GCESG 259
Query: 1238 -----KCN--GFRCP-NGTCIPSSKHCDGLRDCSDGSDEQHCE--PLCTHFMDFVCKNRQ 1287
KC+ + CP +G CI K CDG+ DC DE + C+ + +
Sbjct: 260 PHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQY 319
Query: 1288 QCLFHSMVCDGIIQCRDG---SDEDAAFAGCSQDPEFHKVCDE--------FGFQCQNGV 1336
QC H G C G + D+ D + +CD+ C+ G
Sbjct: 320 QC--HETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGY 377
Query: 1337 CISLIWKCDGMDDCGDYS 1354
+ C D G+ S
Sbjct: 378 ILERGQYCKANDSFGEAS 395
Score = 152 bits (384), Expect = 4e-36
Identities = 97/290 (33%), Positives = 125/290 (43%), Gaps = 74/290 (25%)
Query: 1070 TCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE--------RNCPTT------ 1115
+C E TCL ++++C G CI S W CD DNDCGDMSDE +NC +
Sbjct: 2898 SCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVN 2957
Query: 1116 -------------ICDLD-------------TQFRCQES------GTCIPLSYKCDLEDD 1143
+CD D T+ C E+ G CIP ++CD +D
Sbjct: 2958 DRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHND 3017
Query: 1144 CGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEAN--CTAIYHTCEA 1201
CGD SDE C C+ +++ C +G CI ++VCD DNDC D SDE C TC
Sbjct: 3018 CGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPP 3077
Query: 1202 SNFQCRNGHCIPQRWACDGDTDCQDGSDE---------DPV------NCEKKCNGFRCPN 1246
F+C NG CI C+ DC D SDE DP NC F C
Sbjct: 3078 HEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYC-- 3135
Query: 1247 GTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVC 1296
+C P K R C D + CT M FVC + + + S +C
Sbjct: 3136 -SCRPGYKLMSDKRTCVDIDE-------CTE-MPFVCSQKCENVIGSYIC 3176
Score = 151 bits (381), Expect = 8e-36
Identities = 97/277 (35%), Positives = 125/277 (45%), Gaps = 47/277 (16%)
Query: 1319 PEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCEN 1378
P + CD F+C +G CI W+CDG DC D +DE C T C + + F+C++
Sbjct: 22 PASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVT----CQQGY-FKCQS 76
Query: 1379 -GHCIPNRWKCDRENDCGDWSDEK-DCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTW 1436
G CIPN W CD++ DC D SDE+ DC STC + CS+G C+ +
Sbjct: 77 EGQCIPNSWVCDQDQDCDDGSDERQDCSQ-----------STCSSHQITCSNGQCIPSEY 125
Query: 1437 VCDGYRDCADGSDEEAC--PLLANVTA--ASTPTQLGRCD-------------------R 1473
CD RDC DG+DE C P +T + +CD
Sbjct: 126 RCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLH 185
Query: 1474 FEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSER 1533
EF C + CIP CD DCQDG DE C + TC +F C G CI +
Sbjct: 186 NEFSCGNGE-CIPRAYVCDHDNDCQDGSDEHAC---NYPTCGGYQFTCPSGR-CIYQNWV 240
Query: 1534 CDGFLDCSDESDEKAC-SDELTVYKVQNLQWTADFSG 1569
CDG DC D DE C S V+K +W+ SG
Sbjct: 241 CDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESG 277
Score = 141 bits (355), Expect = 8e-33
Identities = 97/285 (34%), Positives = 128/285 (44%), Gaps = 41/285 (14%)
Query: 1055 DLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPT 1114
D + DCP G N C + TC Q C NG C N+ CD+ DC D SDE NC T
Sbjct: 128 DHVRDCPDGAD--ENDC--QYPTC--EQLTCDNGACYNTSQKCDWKVDCRDSSDEINC-T 180
Query: 1115 TICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSS 1174
IC L +F C +G CIP +Y CD ++DC D SDE C C ++ C SG CI +
Sbjct: 181 EIC-LHNEFSCG-NGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQN 238
Query: 1175 WVCDGDNDCRDWSDEANCTA---IYHTCEASNFQC-RNGHCIPQRWACDGDTDCQDGSDE 1230
WVCDG++DC+D DE C + H C + C +G CI CDG DC DE
Sbjct: 239 WVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDE 298
Query: 1231 D--------------PVNCEKKCN------GFRCPNGTCI--PSSKHCDGLRDCSD-GSD 1267
+ +NC+ +C+ CP G I S+ C DC G
Sbjct: 299 NNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGIC 358
Query: 1268 EQHCEP-----LCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
+Q CE LC ++ + Q C + + I +G D
Sbjct: 359 DQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRD 403
Score = 139 bits (350), Expect = 3e-32
Identities = 84/269 (31%), Positives = 141/269 (52%), Gaps = 13/269 (4%)
Query: 791 VALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVD 850
VA+DFD ++WSD NG T + V+ +S + E +A + + + LYW D
Sbjct: 1469 VAVDFDSISGRIFWSDATQGKTWSAFQNG-TDRRVVFDSSIILTETIAIDWVGRNLYWTD 1527
Query: 851 AGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQ--EGVMFWTDWGDLKPGIYRSNMD 908
+ IEV+ DG R T++ S L PR L L P+ E ++FW+DWG P I R++MD
Sbjct: 1528 YALETIEVSKIDGSHR-TVLISKNLTNPRGLALDPRMNEHLLFWSDWGH-HPRIERASMD 1585
Query: 909 GSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHP 963
GS +V + + WP G+++D ++ +Y+ D+YL+ ++ ++G R ++ + + HP
Sbjct: 1586 GSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHP 1645
Query: 964 YAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGS-NACV 1022
YA+ +F++ +YW D + + RA+K+ G ++ + + + + K S N C
Sbjct: 1646 YALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCA 1705
Query: 1023 PRPCSLLCLPKANNSR--SCRCPEDVSSS 1049
CS LCL + SC CP S S
Sbjct: 1706 FSRCSHLCLLSSQGPHFYSCVCPSGWSLS 1734
Score = 130 bits (327), Expect = 1e-29
Identities = 63/214 (29%), Positives = 128/214 (59%), Gaps = 9/214 (4%)
Query: 790 AVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWV 849
AV + F Y ++W+D + + + +NG QEV+ N +ET E LA + ++ +Y V
Sbjct: 426 AVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVL-NVSVETPENLAVDWVNNKIYLV 484
Query: 850 DAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDL--KPGIYRSNM 907
+ +I++ N DG +R+T++ + L PR + + P G +F++DW L +P + R+ M
Sbjct: 485 ETKVNRIDMVNLDGSYRVTLITEN-LGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFM 543
Query: 908 DGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN---LPH 962
DGS LV + WP G+++D + +YW D+ + IE +T+ G QR ++ +PH
Sbjct: 544 DGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPH 603
Query: 963 PYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEI 996
P+ +++F+ ++++ DW+++++ +A+K++ + ++
Sbjct: 604 PFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQV 637
Score = 125 bits (313), Expect = 6e-28
Identities = 82/274 (29%), Positives = 109/274 (39%), Gaps = 78/274 (28%)
Query: 1315 CSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCE-NPTEAPNCSR--Y 1371
C P F +VC C G+ ++ S+ CE +PT P +
Sbjct: 988 CFPVPNFQRVCG-----CPYGMRLA--------------SNHLTCEGDPTNEPPTEQCGL 1028
Query: 1372 FQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTC 1431
F F C+NG C+PN + CD +DC D SDE+ CG + +TC + + C G C
Sbjct: 1029 FSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLN---------NTCSSSAFTCGHGEC 1079
Query: 1432 VMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRC 1491
+ W CD DC DGSDE CP A + T ++ C + NW C
Sbjct: 1080 IPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDT----------QYTCDNHQCISKNWV-C 1128
Query: 1492 DGHQDCQDGRDEANCPTHSTLT----------CMSREFQCED------------------ 1523
D DC DG DE NC + T C+ F C+
Sbjct: 1129 DTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCT 1188
Query: 1524 --------GEACIVLSERCDGFLDCSDESDEKAC 1549
G+ CI ++ RCDG DCSD SDE C
Sbjct: 1189 ASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGC 1222
Score = 124 bits (310), Expect = 1e-27
Identities = 75/230 (32%), Positives = 126/230 (54%), Gaps = 11/230 (4%)
Query: 835 EALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTD 894
+ +A + + + +YW D K+IEVA DG +R ++++ LD+P A+ + P+ G+MFWTD
Sbjct: 4145 DGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTD-LDQPAAIAVNPKLGLMFWTD 4203
Query: 895 WGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD---DQWIYWTDAYLECIERITFSGQ 951
WG +P I + M+G LV ED+ WP G+S+D + IYW+D + IE I + G
Sbjct: 4204 WGK-EPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGT 4262
Query: 952 QRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFY 1011
R VI +PY++ +F++++YW + +++ +K+ + E L ++IF+
Sbjct: 4263 DRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFH 4322
Query: 1012 KGKNTGS--NACVPRPCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCD 1059
+ + S N C + CS LCL + SC CP+ SS + CD
Sbjct: 4323 QLRYNKSVPNLC-KQICSHLCLLRP-GGYSCACPQ--GSSFIEGSTTECD 4368
Score = 122 bits (307), Expect = 3e-27
Identities = 82/263 (31%), Positives = 114/263 (43%), Gaps = 45/263 (17%)
Query: 1324 VCDEFGFQCQNGV-CISLIWKCDGMDDCGDYSDE-ANCENPTEAPNCSRYFQFRCENGHC 1381
+C F C N CI + WKCDG DC D SDE A C R QF+C +G+C
Sbjct: 3511 MCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQ-----RFCRLGQFQCSDGNC 3565
Query: 1382 IPNRWKCDRENDCGDWSDEKD--CGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCD 1439
+ C+ +C D SDE C + H C N ++C++ C+ ++W CD
Sbjct: 3566 TSPQTLCNAHQNCPDGSDEDRLLCENHH-----------CDSNEWQCANKRCIPESWQCD 3614
Query: 1440 GYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQD 1499
+ DC D SDE++ + C +F C + CIP +CD DC D
Sbjct: 3615 TFNDCEDNSDEDSSHCASRT-----------CRPGQFRCANGR-CIPQAWKCDVDNDCGD 3662
Query: 1500 GRDEA--NCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTVYK 1557
DE C + + L EF C+ CI C+G DC D SDE+ C +E T +
Sbjct: 3663 HSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGC-EERTCHP 3721
Query: 1558 VQN----------LQWTADFSGD 1570
V + L+W D D
Sbjct: 3722 VGDFRCKNHHCIPLRWQCDGQND 3744
Score = 111 bits (277), Expect = 9e-24
Identities = 93/312 (29%), Positives = 155/312 (49%), Gaps = 30/312 (9%)
Query: 758 NEFILYAVRKSI--YRYDLASGATEQLPLTGL-RAAVALDFDYEHNCLYWSDLALDV--- 811
N FI+ ++ +I + +L+ + +P+ G R A+ +D D +YW D + V
Sbjct: 2062 NSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASD 2121
Query: 812 --IQRLCLNGSTGQEVIINS-GLETVEALAFEPLSQLLYWVDAGFKK--IEVANPDGDFR 866
I+R+ +GS+ ++ + G V +A + ++ LY+ +A + IEV + +R
Sbjct: 2122 NAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYR 2181
Query: 867 LTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGI 926
++ +V D PR +V+ P+ +FW D+G +P I RS +D + LVSE + P G+
Sbjct: 2182 RVLLKVTV-DMPRHIVVDPKNRYLFWADYGQ-RPKIERSFLDCTNRTVLVSEGIVTPRGL 2239
Query: 927 SVD--DQWIYWTDAYLECIERITFSGQQRSVIL--DNLPHPYAIAVFKNEIYWDDWSQLS 982
+VD D ++YW D L+ I RI +G+ VI P PY I VF+N I W D +
Sbjct: 2240 AVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKK 2299
Query: 983 IFRASK--YSGSQMEILANQLTGLMDMKIFYK------GKNTGSNACVPR--PCSLLC-- 1030
IF+ASK + ++ + + L D+ IF K +N C+ CS LC
Sbjct: 2300 IFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFA 2359
Query: 1031 LPKANNSRSCRC 1042
LP + + C C
Sbjct: 2360 LPGLHTPK-CDC 2370
Score = 103 bits (257), Expect = 2e-21
Identities = 56/145 (38%), Positives = 72/145 (49%), Gaps = 13/145 (8%)
Query: 1410 PFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLG 1469
P + P C + C +G CV + ++CDG DC D SDE+ C L N ++S T
Sbjct: 1017 PTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFT--- 1073
Query: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIV 1529
C E CIP RCD DC DG DE NCPTH+ +C+ ++ C D CI
Sbjct: 1074 -CGHGE--------CIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTC-DNHQCIS 1123
Query: 1530 LSERCDGFLDCSDESDEKACSDELT 1554
+ CD DC D SDEK C+ T
Sbjct: 1124 KNWVCDTDNDCGDGSDEKNCNSTET 1148
Score = 88.6 bits (218), Expect = 6e-17
Identities = 91/387 (23%), Positives = 165/387 (42%), Gaps = 33/387 (8%)
Query: 745 LEGELVPCPLAEENEFILYAVRKSIYRYDL---ASGATEQLPLTGLRAAVALDFDYEHNC 801
L +L+ C L ++ F++ + I+ L +P+ G++ + ++FD
Sbjct: 1733 LSPDLLNC-LRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQY 1791
Query: 802 LYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANP 861
+YW + + I R+ +G+ S + LA + +S+ LY + + IEV
Sbjct: 1792 IYWVENPGE-IHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTL 1850
Query: 862 DGDFRLT---IVNSSV---LDRPRALVLVPQEGVMFWTDWGD---LKPGIYRSNMDGSAA 912
GD R I N + P + + P G ++W+D G + I +NMDG++
Sbjct: 1851 HGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSV 1910
Query: 913 YHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFK 970
L + +++ +++D +Q +YW IER G R +++ L HP+ IAV
Sbjct: 1911 KTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHD 1970
Query: 971 NEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFY-KGKNTGSNACV--PRPCS 1027
+ +Y+ D I R K +G+ +L + + L +++++ + SN C C
Sbjct: 1971 SFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQ 2030
Query: 1028 LLCLPKANNSRSCRC-------PEDVSSSVLPSGDL--MCDCPQGYQLK----NNTCVKE 1074
+CLP SC C P++ S S S + M +G+ L+ + T V
Sbjct: 2031 QICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPV 2090
Query: 1075 ENTCLRNQYRCSNGNCINSIWWCDFDN 1101
RN I+WCDF +
Sbjct: 2091 AGQG-RNALHVDVDVSSGFIYWCDFSS 2116
Score = 87.8 bits (216), Expect = 1e-16
Identities = 61/182 (33%), Positives = 86/182 (47%), Gaps = 21/182 (11%)
Query: 990 SGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSS 1049
SG + + N+ G+ D N+ C RP P +S +C ED
Sbjct: 1196 SGDKCIGVTNRCDGVFDCS-----DNSDEAGCPTRP------PGMCHSDEFQCQED--GI 1242
Query: 1050 VLPSG---DLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDM 1106
+P+ D DC G ++N CV + TC + + C NGNCI+ W CD DNDCGDM
Sbjct: 1243 CIPNFWECDGHPDCLYGSD-EHNACVPK--TCPSSYFHCDNGNCIHRAWLCDRDNDCGDM 1299
Query: 1107 SDERNCPTTICDLDT-QFRCQESGTCIPLSYKCDLEDDCGDNSDESH-CEMHQCRSDEYN 1164
SDE++CPT + Q++C C+ LS CD DC + +DES C + C
Sbjct: 1300 SDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGG 1359
Query: 1165 CS 1166
C+
Sbjct: 1360 CT 1361
Score = 68.6 bits (166), Expect = 7e-11
Identities = 38/96 (39%), Positives = 45/96 (46%), Gaps = 4/96 (4%)
Query: 1452 ACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHST 1511
AC LL + A P CD F C CIP RCDG +DC D DE C +
Sbjct: 9 ACTLLLALVACLAPASGQECDSAHFRCGSGH-CIPADWRCDGTKDCSDDADEIGC---AV 64
Query: 1512 LTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEK 1547
+TC F+C+ CI S CD DC D SDE+
Sbjct: 65 VTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDER 100
Score = 64.3 bits (155), Expect = 1e-09
Identities = 73/300 (24%), Positives = 109/300 (36%), Gaps = 78/300 (26%)
Query: 1013 GKNTGSNACVPRPCSLLCLPKANNSRSCRCPE-----DVSSSVLPSGDLMCDCPQGY--- 1064
G N+ C R C P+ S C D S+ L + D DCP +
Sbjct: 3785 GDNSDERDCEMRTCH----PEYFQCTSGHCVHSELKCDGSADCLDASD-EADCPTRFPDG 3839
Query: 1065 --------QLKNNTCV-----------------KEENTCLR------NQYRCSNGNCINS 1093
+ KN+ C+ +E + CL N++RC N CI S
Sbjct: 3840 AYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYS 3899
Query: 1094 IWWCDFDNDCGDMSDE--RNC--PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSD 1149
C+ +DCGD +DE +C PT + +++C +G CIP CD DDCGD SD
Sbjct: 3900 HEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCG-NGHCIPHDNVCDDADDCGDWSD 3958
Query: 1150 ESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDE---ANCTAIYHTCEASNFQC 1206
E C + E C+ +C + +C ++ +CTA + T C
Sbjct: 3959 ELGCN----KGKERTCAENIC---------EQNCTQLNEGGFICSCTAGFETNVFDRTSC 4005
Query: 1207 RNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGS 1266
+ + Q C P +C + C S G R ++GS
Sbjct: 4006 LDINECEQFGTC-------------PQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGS 4052
Score = 60.8 bits (146), Expect = 1e-08
Identities = 33/82 (40%), Positives = 37/82 (45%), Gaps = 7/82 (8%)
Query: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEAN--CPTHSTLTCMSREFQCEDGEAC 1527
RC F C + WK CD DC DG DE C H TC F C +G C
Sbjct: 2699 RCGASSFTCSNGRCISEEWK-CDNDNDCGDGSDEMESVCALH---TCSPTAFTCANGR-C 2753
Query: 1528 IVLSERCDGFLDCSDESDEKAC 1549
+ S RCD + DC D SDE C
Sbjct: 2754 VQYSYRCDYYNDCGDGSDEAGC 2775
>gi|93102379 low density lipoprotein-related protein 1B precursor
[Homo sapiens]
Length = 4599
Score = 432 bits (1112), Expect = e-120
Identities = 281/864 (32%), Positives = 408/864 (47%), Gaps = 123/864 (14%)
Query: 754 LAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLAL---D 810
L++E F++ A I + G+ L GL +A+DFDY +YW D +
Sbjct: 3010 LSDEEPFLILADHHEIRKIS-TDGSNYTLLKQGLNNVIAIDFDYREEFIYWIDSSRPNGS 3068
Query: 811 VIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIV 870
I R+CLNGS +V+ N+ + ALA + + + LYW D + IEV+ +G + TI+
Sbjct: 3069 RINRMCLNGSD-IKVVHNTAVPN--ALAVDWIGKNLYWSDTEKRIIEVSKLNGLYP-TIL 3124
Query: 871 NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD- 929
S L PR L L PQ G ++W D + P I R MDG+ ++ + P +++D
Sbjct: 3125 VSKRLKFPRDLSLDPQAGYLYWIDCCEY-PHIGRVGMDGTNQSVVIETKISRPMALTIDY 3183
Query: 930 -DQWIYWTDAYLECIERITFSGQQRSVILD-NLPHPYAIAVFKNEIYWDDWSQLSIFRAS 987
++ +YW D IE G R + + ++P A+ +F++ IYW D S+ RA
Sbjct: 3184 VNRRLYWADE--NHIEFSNMDGSHRHKVPNQDIPGVIALTLFEDYIYWTDGKTKSLSRAH 3241
Query: 988 KYSGSQMEILANQLTGLMDMKIF--YKGKNTGSNACVPRP--CSLLCLPKANNSRSCRCP 1043
K SG+ L + D++++ Y+ + + C+ CS LCL + +C CP
Sbjct: 3242 KTSGADRLSLIYSWHAITDIQVYHSYRQPDVSKHLCMINNGGCSHLCLLAPGKTHTCACP 3301
Query: 1044 EDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDC 1103
+ + N TC+ + C +Q+RC CI W CD +DC
Sbjct: 3302 TNFYLAA----------------DNRTCL---SNCTASQFRCKTDKCIPFWWKCDTVDDC 3342
Query: 1104 GDMSDERN-CPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDE 1162
GD SDE + CP C +F+C +G C ++ CD E+DCGDNSDE +C+ H C S +
Sbjct: 3343 GDGSDEPDDCPEFRCQ-PGRFQCG-TGLCALPAFICDGENDCGDNSDELNCDTHVCLSGQ 3400
Query: 1163 YNCSSGM-CIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNG-HCIPQRWACDG 1220
+ C+ CI + C+G +DC D DE +C ++C FQC+ HCI + W CD
Sbjct: 3401 FKCTKNQKCIPVNLRCNGQDDCGDEEDERDCPE--NSCSPDYFQCKTTKHCISKLWVCDE 3458
Query: 1221 DTDCQDGSDEDPVNCEKKCNG---FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTH 1277
D DC D SDE NC+KK G F+C N CIP CD DCSD SDE++C+P
Sbjct: 3459 DPDCADASDE--ANCDKKTCGPHEFQCKNNNCIPDHWRCDSQNDCSDNSDEENCKPQTCT 3516
Query: 1278 FMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVC 1337
DF+C N C+ CDG C DGSDE CS+D F+C NG C
Sbjct: 3517 LKDFLCANGD-CVSSRFWCDGDFDCADGSDERNCETSCSKDQ----------FRCSNGQC 3565
Query: 1338 ISLIWKCDGMDDCGDYSDEANCENPTEAPNCS---------------------------- 1369
I WKCDG +DC DE +CE +P CS
Sbjct: 3566 IPAKWKCDGHEDCKYGEDEKSCE--PASPTCSSREYICASDGCISASLKCNGEYDCADGS 3623
Query: 1370 ---------RYFQFRCEN-GHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTC 1419
+ QFRC+N HCIP RW CD +DC D SDE++C G + C
Sbjct: 3624 DEMDCVTECKEDQFRCKNKAHCIPIRWLCDGIHDCVDGSDEENC---------ERGGNIC 3674
Query: 1420 LPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECH 1479
+ + C++ C + WVCDG DC D SDE + + ++ P + C
Sbjct: 3675 RADEFLCNNSLCKLHFWVCDGEDDCGDNSDEAPDMCVKFLCPSTRPHR----------CR 3724
Query: 1480 QPKTCIPNWKRCDGHQDCQDGRDEANCP---THSTLTCMSREFQCEDGEACIVLSERCDG 1536
+ C+ + + C+G +C D DE +C T+ C EF C + + CI + +CD
Sbjct: 3725 NNRICLQSEQMCNGIDECGDNSDEDHCGGKLTYKARPCKKDEFACSN-KKCIPMDLQCDR 3783
Query: 1537 FLDCSDESDEKACSDELTVYKVQN 1560
DC D SDE+ C T Y ++
Sbjct: 3784 LDDCGDGSDEQGCRIAPTEYTCED 3807
Score = 389 bits (998), Expect = e-107
Identities = 264/819 (32%), Positives = 370/819 (45%), Gaps = 128/819 (15%)
Query: 791 VALDFDYEH-----NCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQL 845
+AL FDY N +++SD IQ + N Q ++ N G +VE LA+
Sbjct: 2225 IALAFDYNQRRKGTNRIFYSDAHFGNIQLIKDNWEDRQVIVENVG--SVEGLAYHRAWDT 2282
Query: 846 LYWVDAGFKKI-----EVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKP 900
LYW + I + P R ++ S D P L L + +MFWT+W + P
Sbjct: 2283 LYWTSSTTSSITRHTVDQTRPGAFDREAVITMSEDDHPHVLALDECQNLMFWTNWNEQHP 2342
Query: 901 GIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILD 958
I RS + G A +VS D+ PNG+++D + +Y++D L IER + G QR VI+
Sbjct: 2343 SIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQRHVIVK 2402
Query: 959 NLPHPY-AIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTG 1017
+ P + ++AV+ N I+W DW + +I R++KY+G +IL + + M I +T
Sbjct: 2403 SGPGTFLSLAVYDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPH-QPMGIIAVANDT- 2460
Query: 1018 SNACVPRPCSLL-------CLPKANNSRSCRCPED---VSSSVLPSGDLMCDCPQGYQLK 1067
N+C PC+LL CL N +C C D + + + + C+ ++
Sbjct: 2461 -NSCELSPCALLNGGCHDLCLLTPNGRVNCSCRGDRILLEDNRCVTKNSSCNAYSEFECG 2519
Query: 1068 NNTCVK----------------------EENTCLRNQYRCSNGNCINSIWWCDFDNDCGD 1105
N C+ E +C R C N CI CD +NDCGD
Sbjct: 2520 NGECIDYQLTCDGIPHCKDKSDEKLLYCENRSCRRGFKPCYNRRCIPHGKLCDGENDCGD 2579
Query: 1106 MSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCR------ 1159
SDE +C + C +FRC + GTCIP S +C+ DC D SDE +C C
Sbjct: 2580 NSDELDCKVSTC-ATVEFRCAD-GTCIPRSARCNQNIDCADASDEKNCNNTDCTHFYKLG 2637
Query: 1160 ---SDEYNCSS-GMCIRSSWVCDGDNDCRDWSDEANCTAIY-HTCEASNFQCRNGHCIPQ 1214
+ C+S +C+ +W+CDG NDC D+SDE C H CE + F C +G CI
Sbjct: 2638 VKTTGFIRCNSTSLCVLPTWICDGSNDCGDYSDELKCPVQNKHKCEENYFSCPSGRCILN 2697
Query: 1215 RWACDGDTDCQDGSDEDPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQH-- 1270
W CDG DC+DG DE +C+ C N F C CI CDG DC DG DE
Sbjct: 2698 TWICDGQKDCEDGRDE--FHCDSSCSWNQFACSAQKCISKHWICDGEDDCGDGLDESDSI 2755
Query: 1271 CEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGF 1330
C + F C+ + C+ +CDG C DGSDE + AGC+ + CDE F
Sbjct: 2756 CGAITCAADMFSCQGSRACVPRHWLCDGERDCPDGSDE-LSTAGCAP----NNTCDENAF 2810
Query: 1331 QCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQ-----FRCENGHCIPN- 1384
C N VCI + CD DDCGD SD E+P C Y Q F C +G C+ N
Sbjct: 2811 MCHNKVCIPKQFVCDHDDDCGDGSD--------ESPQCG-YRQCGTEEFSCADGRCLLNT 2861
Query: 1385 RWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDC 1444
+W+CD + DC D SDE + + P +C +++ C +G C+ +CD DC
Sbjct: 2862 QWQCDGDFDCPDHSDE-----APLNPKCKSAEQSCNSSFFMCKNGRCIPSGGLCDNKDDC 2916
Query: 1445 ADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA 1504
DGSDE C + EC K C QDCQD
Sbjct: 2917 GDGSDERNCHI--------------------NECLSKKV-----SGCS--QDCQD----- 2944
Query: 1505 NCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDE 1543
P C +DG+ C+ + E GF CS +
Sbjct: 2945 -LPVSYKCKCWPGFQLKDDGKTCVDIDECSSGF-PCSQQ 2981
Score = 351 bits (901), Expect = 4e-96
Identities = 220/636 (34%), Positives = 316/636 (49%), Gaps = 77/636 (12%)
Query: 782 LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEP 841
+P+ L ALDF E N +Y++D +I R ++G T +E I+ L+ VE +A +
Sbjct: 550 IPIENLVNPRALDFHAETNYIYFADTTSFLIGRQKIDG-TERETILKDDLDNVEGIAVDW 608
Query: 842 LSQLLYWVDAGFKK-IEVANPD--GDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDW--- 895
+ LYW + G +K I VA + R T++ + PR +V+ P G M+WTDW
Sbjct: 609 IGNNLYWTNDGHRKTINVARLEKASQSRKTLLEGE-MSHPRGIVVDPVNGWMYWTDWEED 667
Query: 896 --GDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQ 951
D I ++ MDG V+ + WPNG+++D +YW DAY + IE++ +G
Sbjct: 668 EIDDSVGRIEKAWMDGFNRQIFVTSKMLWPNGLTLDFHTNTLYWCDAYYDHIEKVFLNGT 727
Query: 952 QRSVILDN--LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKI 1009
R ++ L HP+ ++ N ++W D+ SIF+ + S++ +L ++ L ++I
Sbjct: 728 HRKIVYSGRELNHPFGLSHHGNYVFWTDYMNGSIFQLDLIT-SEVTLLRHERPPLFGLQI 786
Query: 1010 FYKGKNTGSNACVPRP--CSLLCLPKANNSRSCRCPED-------VSSSVLPSGDLMCDC 1060
+ K G N C CS LCL R C C ++ + + P L C
Sbjct: 787 YDPRKQQGDNMCRVNNGGCSTLCLA-IPGGRVCACADNQLLDENGTTCTFNPGEALPHIC 845
Query: 1061 PQG-YQLKNNTCVKEE----------------------NTCLRNQYRCSNGNCINSIWWC 1097
G ++ KN C++ ++C +Q++C N CI W C
Sbjct: 846 KAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLC 905
Query: 1098 DFDNDCGDMSDERN--CPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDE-SHCE 1154
D NDCG DE N C C +D QF C +G CIP ++ CD EDDCGD +DE + CE
Sbjct: 906 DGANDCGSNEDESNQTCTARTCQVD-QFSC-GNGRCIPRAWLCDREDDCGDQTDEMASCE 963
Query: 1155 MHQCRS-DEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIP 1213
C ++ C SG CI S W CD D+DC D SDE C H+C + F+C +G CIP
Sbjct: 964 FPTCEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCV---HSCFDNQFRCSSGRCIP 1020
Query: 1214 QRWACDGDTDCQDGSDEDPVNCEKK-------CNG--FRC-PNGTCIPSSKHCDGLRDCS 1263
WACDGD DC D SDE +NC K+ CNG F+C P+G C+P CDG +DC
Sbjct: 1021 GHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLWRCDGEKDCE 1080
Query: 1264 DGSDEQHCE---PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPE 1320
DGSDE+ C LC H F C + +C+ + VCDG I C D SDED + P+
Sbjct: 1081 DGSDEKGCNGTIRLCDHKTKFSCWSTGRCINKAWVCDGDIDCEDQSDEDDCDSFLCGPPK 1140
Query: 1321 FHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE 1356
H ++ VC+ C+G DC D SDE
Sbjct: 1141 -HPCAND------TSVCLQPEKLCNGKKDCPDGSDE 1169
Score = 251 bits (642), Expect = 4e-66
Identities = 160/417 (38%), Positives = 201/417 (48%), Gaps = 51/417 (12%)
Query: 1156 HQCRSDEYNCSS-GMCIRSSWVCD-GDNDCRDWSDEANCT-----AIYHTCEASNFQCRN 1208
+ CR + CS+ + I VC DN D + CT A+ H C+A F+C+N
Sbjct: 796 NMCRVNNGGCSTLCLAIPGGRVCACADNQLLD-ENGTTCTFNPGEALPHICKAGEFRCKN 854
Query: 1209 GHCIPQRWACDGDTDCQDGSDEDPVNC-EKKC--NGFRCPNGTCIPSSKHCDGLRDCSDG 1265
HCI RW CDGD DC DGSDED VNC C + F+C N CIP CDG DC
Sbjct: 855 RHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKRWLCDGANDCGSN 914
Query: 1266 SDE--QHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHK 1323
DE Q C F C N +C+ + +CD C D +DE A C EF
Sbjct: 915 EDESNQTCTARTCQVDQFSCGN-GRCIPRAWLCDREDDCGDQTDE---MASC----EFPT 966
Query: 1324 VCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIP 1383
F C++G CIS W CD DDCGD SDE C + +C QFRC +G CIP
Sbjct: 967 CEPLTQFVCKSGRCISSKWHCDSDDDCGDGSDEVGCVH-----SCFDN-QFRCSSGRCIP 1020
Query: 1384 NRWKCDRENDCGDWSDEK--DCGDSHILPFSTPGPSTCLPNYYRC-SSGTCVMDTWVCDG 1440
W CD +NDCGD+SDE +C I P+ C N ++C G CV D W CDG
Sbjct: 1021 GHWACDGDNDCGDFSDEAQINCTKEEI-----HSPAGCNGNEFQCHPDGNCVPDLWRCDG 1075
Query: 1441 YRDCADGSDEEACPLLANVTAASTPTQLGRCD-RFEFECHQPKTCIPNWKRCDGHQDCQD 1499
+DC DGSDE+ C N T + CD + +F C CI CDG DC+D
Sbjct: 1076 EKDCEDGSDEKGC----NGT-------IRLCDHKTKFSCWSTGRCINKAWVCDGDIDCED 1124
Query: 1500 GRDEANCPTHSTLTCMSREFQC-EDGEACIVLSERCDGFLDCSDESDEKACSDELTV 1555
DE +C + C + C D C+ + C+G DC D SDE DE ++
Sbjct: 1125 QSDEDDC---DSFLCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDEGYLCDECSL 1178
Score = 248 bits (632), Expect = 6e-65
Identities = 149/446 (33%), Positives = 207/446 (46%), Gaps = 69/446 (15%)
Query: 1156 HQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQR 1215
H C++ E+ C + CI++ W CDGD+DC D SDE + H+C F+C+N CIP+R
Sbjct: 843 HICKAGEFRCKNRHCIQARWKCDGDDDCLDGSDEDSVNCFNHSCPDDQFKCQNNRCIPKR 902
Query: 1216 WACDGDTDCQDGSDEDPVNCEKK---CNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQ-HC 1271
W CDG DC DE C + + F C NG CIP + CD DC D +DE C
Sbjct: 903 WLCDGANDCGSNEDESNQTCTARTCQVDQFSCGNGRCIPRAWLCDREDDCGDQTDEMASC 962
Query: 1272 E-PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGF 1330
E P C FVCK+ +C+ CD C DGSDE GC C + F
Sbjct: 963 EFPTCEPLTQFVCKS-GRCISSKWHCDSDDDCGDGSDE----VGCVHS------CFDNQF 1011
Query: 1331 QCQNGVCISLIWKCDGMDDCGDYSDEA--NC-ENPTEAPNCSRYFQFRCE-NGHCIPNRW 1386
+C +G CI W CDG +DCGD+SDEA NC + +P +F+C +G+C+P+ W
Sbjct: 1012 RCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHSPAGCNGNEFQCHPDGNCVPDLW 1071
Query: 1387 KCDRENDCGDWSDEKDC-GDSHILPFSTPGPSTCLPNYYRC-SSGTCVMDTWVCDGYRDC 1444
+CD E DC D SDEK C G + T + C S+G C+ WVCDG DC
Sbjct: 1072 RCDGEKDCEDGSDEKGCNGTIRLCDHKTK---------FSCWSTGRCINKAWVCDGDIDC 1122
Query: 1445 ADGSDEEACPLLANVTAASTPTQLGRCDRFEFEC-HQPKTCIPNWKRCDGHQDCQDGRDE 1503
D SDE+ C C + C + C+ K C+G +DC DG DE
Sbjct: 1123 EDQSDEDDCDSFL-------------CGPPKHPCANDTSVCLQPEKLCNGKKDCPDGSDE 1169
Query: 1504 -----------ANCPTHSTL--------TCMSREFQCEDGEACIVLSERCDGFLDCSDES 1544
C H ++ +C +D + C ++ + C L CS
Sbjct: 1170 GYLCDECSLNNGGCSNHCSVVPGRGIVCSCPEGLQLNKDNKTCEIV-DYCSNHLKCSQVC 1228
Query: 1545 DEKACSDELTVYKVQNLQWTADFSGD 1570
++ + + + Y+ W D G+
Sbjct: 1229 EQHKHTVKCSCYE----GWKLDVDGE 1250
Score = 179 bits (455), Expect = 2e-44
Identities = 101/300 (33%), Positives = 166/300 (55%), Gaps = 19/300 (6%)
Query: 760 FILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNG 819
FI++++R I R DL L + GLR +ALDF + + LYW+D+ D I R L+
Sbjct: 1261 FIIFSIRHEIRRIDLHK-RDYSLLVPGLRNTIALDFHFNQSLLYWTDVVEDRIYRGKLSE 1319
Query: 820 STGQ---EVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876
S G EV++ GL T E L + ++ +YW+D+ +IEVA DG R T++ + ++
Sbjct: 1320 SGGVSAIEVVVEHGLATPEGLTVDWIAGNIYWIDSNLDQIEVAKLDGSLRTTLI-AGAME 1378
Query: 877 RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVK---WPNGISVD--DQ 931
PRA+ L P+ G++FWTDW P I ++M G A + +D+K WPNG++VD ++
Sbjct: 1379 HPRAIALDPRYGILFWTDWDANFPRIESASMSG-AGRKTIYKDMKTGAWPNGLTVDHFEK 1437
Query: 932 WIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
I WTDA + I + G I+ + L HP+A++++ +E+YW DW ++ +A+K
Sbjct: 1438 RIVWTDARSDAIYSALYDGTNMIEIIRGHEYLSHPFAVSLYGSEVYWTDWRTNTLSKANK 1497
Query: 989 YSGSQMEILANQLTGLMDMKIFYKGKN-TGSNACVPR----PCSLLCLPKANNSRSCRCP 1043
++G + ++ D++I++ + N C PCS +CL N S +C CP
Sbjct: 1498 WTGQNVSVIQKTSAQPFDLQIYHPSRQPQAPNPCAANDGKGPCSHMCLINHNRSAACACP 1557
Score = 171 bits (432), Expect = 1e-41
Identities = 107/318 (33%), Positives = 171/318 (53%), Gaps = 18/318 (5%)
Query: 760 FILYAVRKSIYRYDL--ASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCL 817
F++Y+V + I L + +P++G AV +DF E++ +YW+D+ + I R
Sbjct: 1880 FLMYSVHEGIRGIPLEPSDKMDALMPISGTSFAVGIDFHAENDTIYWTDMGFNKISR-AK 1938
Query: 818 NGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDR 877
T +E II +GL VE +A + ++ +YW D GF IEVA +G FR I+ S LD+
Sbjct: 1939 RDQTWKEDIITNGLGRVEGIAVDWIAGNIYWTDHGFNLIEVARLNGSFRYVII-SQGLDQ 1997
Query: 878 PRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYW 935
PR++ + P++G++FWT+WG + P I ++ +DGS LVS + WPNGIS+D + +YW
Sbjct: 1998 PRSIAVHPEKGLLFWTEWGQM-PCIGKARLDGSEKVVLVSMGIAWPNGISIDYEENKLYW 2056
Query: 936 TDAYLECIERITF--SGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQL--SIFRASKYSG 991
DA + IERI G + V+ + +++AVF IYW D + S+ R K
Sbjct: 2057 CDARTDKIERIDLETGGNREMVLSGSNVDMFSVAVFGAYIYWSDRAHANGSVRRGHKNDA 2116
Query: 992 SQMEILANQL-TGLMDMKIFYKGKNTGSNACV--PRPCSLLCLPKANNSRSCRCPEDVSS 1048
++ + L L ++KIF + + G+N C C LCL + N+ R+C C +
Sbjct: 2117 TETITMRTGLGVNLKEVKIFNRVREKGTNVCARDNGGCKQLCLYRGNSRRTCAC----AH 2172
Query: 1049 SVLPSGDLMCDCPQGYQL 1066
L + C +GY L
Sbjct: 2173 GYLAEDGVTCLRHEGYLL 2190
Score = 145 bits (367), Expect = 3e-34
Identities = 107/319 (33%), Positives = 144/319 (45%), Gaps = 62/319 (19%)
Query: 1017 GSNACVPRP--CSLL--CLPKANNSRSCRCP--EDVSSSVLPSG---------DLMCDCP 1061
G+ C+PR C C + + SC P E ++ V SG D DC
Sbjct: 935 GNGRCIPRAWLCDREDDCGDQTDEMASCEFPTCEPLTQFVCKSGRCISSKWHCDSDDDCG 994
Query: 1062 QGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDT 1121
G CV ++C NQ+RCS+G CI W CD DNDCGD SDE T ++ +
Sbjct: 995 DGSDEVG--CV---HSCFDNQFRCSSGRCIPGHWACDGDNDCGDFSDEAQINCTKEEIHS 1049
Query: 1122 -------QFRCQESGTCIPLSYKCDLEDDCGDNSDESHCE--MHQC-RSDEYNC-SSGMC 1170
+F+C G C+P ++CD E DC D SDE C + C +++C S+G C
Sbjct: 1050 PAGCNGNEFQCHPDGNCVPDLWRCDGEKDCEDGSDEKGCNGTIRLCDHKTKFSCWSTGRC 1109
Query: 1171 IRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRN--GHCIPQRWACDGDTDCQDGS 1228
I +WVCDGD DC D SDE +C + C C N C+ C+G DC DGS
Sbjct: 1110 INKAWVCDGDIDCEDQSDEDDCDSF--LCGPPKHPCANDTSVCLQPEKLCNGKKDCPDGS 1167
Query: 1229 DEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLR------DCSDG----SDEQHCEPLCTHF 1278
DE + C+ NG C S HC + C +G D + CE
Sbjct: 1168 DEGYL-----CDECSLNNGGC---SNHCSVVPGRGIVCSCPEGLQLNKDNKTCE-----I 1214
Query: 1279 MDFVCKNRQQCLFHSMVCD 1297
+D+ C N +C S VC+
Sbjct: 1215 VDY-CSNHLKC---SQVCE 1229
Score = 138 bits (347), Expect = 7e-32
Identities = 88/299 (29%), Positives = 150/299 (50%), Gaps = 20/299 (6%)
Query: 756 EENEFILYAVRKSIYRYDLAS---GATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVI 812
E +F+LYA R I D+ + + + +DFD LYW+D+ I
Sbjct: 1571 EMKKFLLYARRSEIRGVDIDNPYFNFITAFTVPDIDDVTVIDFDASEERLYWTDIKTQTI 1630
Query: 813 QRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKK--IEVANPDGDFRLTIV 870
+R +NG TG E +I+ ++++ LA + +S+ LYW+ + F + I VA DG + +I+
Sbjct: 1631 KRAFING-TGLETVISRDIQSIRGLAVDWVSRNLYWISSEFDETQINVARLDGSLKTSII 1689
Query: 871 NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD- 929
+ +D+P+ L P G ++WTD + +NMDGS + ++ ++ K P G+S+D
Sbjct: 1690 HG--IDKPQCLAAHPVRGKLYWTDGNTIN----MANMDGSNS-KILFQNQKEPVGLSIDY 1742
Query: 930 -DQWIYWTDAYLECIERITFSGQQRSVI---LDNLPHPYAIAVFKNEIYWDDWSQLSIFR 985
+ +YW + I R G VI + L A+ + +++W D + +
Sbjct: 1743 VENKLYWISSGNGTINRCNLDGGNLEVIESMKEELTKATALTIMDKKLWWADQNLAQLGT 1802
Query: 986 ASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRC 1042
SK G IL N+ +G++ MK++ K GSN+C CS LCLP + +R+C C
Sbjct: 1803 CSKRDGRNPTILRNKTSGVVHMKVYDKEAQQGSNSCQLNNGGCSQLCLPTSETTRTCMC 1861
Score = 103 bits (256), Expect = 2e-21
Identities = 111/414 (26%), Positives = 167/414 (40%), Gaps = 68/414 (16%)
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
+++ P A+ + P+ G+M+WT GD I + MDG+ LV ++++ P G++VD
Sbjct: 4023 TNMAGEPYAIAVNPKRGMMYWTVVGD-HSHIEEAAMDGTLRRILVQKNLQRPTGLAVDYF 4081
Query: 930 DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHPYAIAVFKNEIYWDDWSQLSIFRA 986
+ IYW D L I + + G V + + L HP+ I +F++ IY + +FR
Sbjct: 4082 SERIYWADFELSIIGSVLYDGSNSVVSVSSKQGLLHPHRIDIFEDYIY-GAGPKNGVFRV 4140
Query: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKNTG-SNACVPRPCSLLCLPKANNSRSCRCPED 1045
K+ +E LA + + I ++ K N C+ C LCL + + +C CPE
Sbjct: 4141 QKFGHGSVEYLALNIDKTKGVLISHRYKQLDLPNPCLDLACEFLCLLNPSGA-TCVCPEG 4199
Query: 1046 V--------SSSVL-----------------PSGDLMCDCPQGYQLKNNTCVKEENTCLR 1080
S+L GDL C C Y C E N C
Sbjct: 4200 KYLINGTCNDDSLLDDSCKLTCENGGRCILNEKGDLRCHCWPSY--SGERC--EVNHC-- 4253
Query: 1081 NQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDL 1140
+ Y + G C+ S+ C NC T+C+ F CQ GTCI +
Sbjct: 4254 SNYCQNGGTCVPSVLGRP-TCSCALGFTGPNCGKTVCE---DF-CQNGGTCIVTA----- 4303
Query: 1141 EDDCGDNSDESHCEMHQC--RSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYH- 1197
N HC+ R Y C C+ S GD D S E C Y
Sbjct: 4304 -----GNQPYCHCQPEYTGDRCQYYVCHH-YCVNSESCTIGD----DGSVECVCPTRYEG 4353
Query: 1198 -TCEASN-FQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTC 1249
CE +C GHCI + + D +C +G +C+ C+G+ GTC
Sbjct: 4354 PKCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIAS--SCQ-LCDGYCYNGGTC 4404
Score = 97.4 bits (241), Expect = 1e-19
Identities = 69/269 (25%), Positives = 135/269 (50%), Gaps = 22/269 (8%)
Query: 793 LDFDYEHNCLYWSDLALDVIQRLCLN----GSTGQEVIIN--SGLETVEALAFEPLSQLL 846
LDF Y + + W + Q C+ G E IN V+ +A + L++ L
Sbjct: 238 LDFIYNEDMICWIESRESSNQLKCIQITKAGGLTDEWTINILQSFHNVQQMAIDWLTRNL 297
Query: 847 YWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSN 906
Y+VD +I V N +G +T+++ L P+A+ + P G +F+TD+G++ + R +
Sbjct: 298 YFVDHVGDRIFVCNSNGSVCVTLIDLE-LHNPKAIAVDPIAGKLFFTDYGNVAK-VERCD 355
Query: 907 MDGSAAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILD--NLPH 962
MDG ++ + P +++D ++ +YW D YL+ + + + G+ R ++ + H
Sbjct: 356 MDGMNRTRIIDSKTEQPAALALDLVNKLVYWVDLYLDYVGVVDYQGKNRHTVIQGRQVRH 415
Query: 963 PYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYK--GKNTGSNA 1020
Y I VF++ +Y + +I R ++++G+ + L ++ ++I+ K S+A
Sbjct: 416 LYGITVFEDYLYATNSDNYNIVRINRFNGTDIHSLI-KIENAWGIRIYQKRTQPTVRSHA 474
Query: 1021 C------VPRPCSLLCLPKAN-NSRSCRC 1042
C +P CS +CL ++ +R+CRC
Sbjct: 475 CEVDPYGMPGGCSHICLLSSSYKTRTCRC 503
Score = 72.8 bits (177), Expect = 4e-12
Identities = 48/136 (35%), Positives = 63/136 (46%), Gaps = 17/136 (12%)
Query: 1199 CEASNFQCRNG-HCIPQRWACDGDTDCQDGSDED----PVNCEKKC--NGFRC-PNGTCI 1250
C+ F C + C+ Q W CDGD DC D SDE P E KC N C C+
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 1251 PSSKHCDGLRDCSDGSDE-QHCEPLCTHFMDFVCKNRQQCLFHSMVC---DGIIQCRDG- 1305
S+ C+G+ DC DG DE HC+ L ++ C+ + + +S C DG DG
Sbjct: 92 HLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDGR 151
Query: 1306 ----SDEDAAFAGCSQ 1317
DE A + CSQ
Sbjct: 152 SCKDQDECAVYGTCSQ 167
Score = 66.6 bits (161), Expect = 3e-10
Identities = 35/100 (35%), Positives = 42/100 (42%), Gaps = 2/100 (2%)
Query: 1456 LANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA--NCPTHSTLT 1513
+A V CD EF CH TC+ CDG DC D DE+ CP +
Sbjct: 17 IARVLTVGADRDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIK 76
Query: 1514 CMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDEL 1553
C C C+ LS+ C+G LDC D DE EL
Sbjct: 77 CPLNHIACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQEL 116
Score = 63.9 bits (154), Expect = 2e-09
Identities = 48/152 (31%), Positives = 68/152 (44%), Gaps = 19/152 (12%)
Query: 1073 KEENTCLRNQYRCSNG-NCINSIWWCDFDNDCGDMSDER--NCPTTI---CDLDTQFRCQ 1126
+++ C ++ C + C++ W CD D DC D SDE CP + C L+ C
Sbjct: 27 RDQQLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLN-HIACL 85
Query: 1127 ESGTCIPLSYKCDLEDDCGDNSDES-HCEMHQCRSDEYNCS-SGMCIRSSWVC---DG-- 1179
+ C+ LS C+ DC D DE HC+ + NC +R+S C DG
Sbjct: 86 GTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFE 145
Query: 1180 -DNDCRDWSDEANCTAIYHTCEASNFQCRNGH 1210
D R D+ C A+Y TC + CRN H
Sbjct: 146 ITEDGRSCKDQDEC-AVYGTCSQT---CRNTH 173
Score = 58.5 bits (140), Expect = 7e-08
Identities = 41/129 (31%), Positives = 57/129 (44%), Gaps = 16/129 (12%)
Query: 1158 CRSDEYNCSSGM-CIRSSWVCDGDNDCRDWSDEANCTA---IYHTCEASNFQC-RNGHCI 1212
C E+ C + C+ SW+CDGD DC D SDE+ T + C ++ C C+
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNKCV 91
Query: 1213 PQRWACDGDTDCQDGSDEDPVNCEK---KCNGFRCP-NGTCIPSSKHC---DGLRDCSDG 1265
C+G DC DG DE V+C++ C C T + +S C DG DG
Sbjct: 92 HLSQLCNGVLDCPDGYDEG-VHCQELLSNCQQLNCQYKCTMVRNSTRCYCEDGFEITEDG 150
Query: 1266 ---SDEQHC 1271
D+ C
Sbjct: 151 RSCKDQDEC 159
Score = 56.6 bits (135), Expect = 3e-07
Identities = 47/159 (29%), Positives = 74/159 (46%), Gaps = 21/159 (13%)
Query: 1116 ICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDES--HCEMH---QCRSDEYNC-SSGM 1169
+CD +F C + TC+ S+ CD + DC D+SDES C +C + C +
Sbjct: 31 LCD-PGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEIKCPLNHIACLGTNK 89
Query: 1170 CIRSSWVCDGDNDCRDWSDE-ANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGS 1228
C+ S +C+G DC D DE +C + C+ N Q + C R + C+DG
Sbjct: 90 CVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYK---CTMVRNST--RCYCEDGF 144
Query: 1229 D--EDPVNC--EKKCNGFRCPNGTCIPSSKHCDGLRDCS 1263
+ ED +C + +C + GTC + ++ G CS
Sbjct: 145 EITEDGRSCKDQDECAVY----GTCSQTCRNTHGSYTCS 179
Score = 56.6 bits (135), Expect = 3e-07
Identities = 37/122 (30%), Positives = 47/122 (38%), Gaps = 26/122 (21%)
Query: 1419 CLPNYYRCSSG-TCVMDTWVCDGYRDCADGSDE--EACPLLANVTAASTPTQLGRCDRFE 1475
C P + C TCV +W+CDG DC D SDE + CP + +C
Sbjct: 32 CDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDESLDTCPEEVEI----------KCPLNH 81
Query: 1476 FECHQPKTCIPNWKRCDGHQDCQDGRDEA-------------NCPTHSTLTCMSREFQCE 1522
C C+ + C+G DC DG DE NC T+ S CE
Sbjct: 82 IACLGTNKCVHLSQLCNGVLDCPDGYDEGVHCQELLSNCQQLNCQYKCTMVRNSTRCYCE 141
Query: 1523 DG 1524
DG
Sbjct: 142 DG 143
Score = 48.1 bits (113), Expect = 9e-05
Identities = 59/272 (21%), Positives = 93/272 (34%), Gaps = 78/272 (28%)
Query: 1323 KVCDEFGFQCQNGV-CISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHC 1381
++CD F C + V C+S W CDG DC D SDE+ C + +C H
Sbjct: 30 QLCDPGEFLCHDHVTCVSQSWLCDGDPDCPDDSDES-------LDTCPEEVEIKCPLNHI 82
Query: 1382 IPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGY 1441
CL + CV + +C+G
Sbjct: 83 ------------------------------------ACL------GTNKCVHLSQLCNGV 100
Query: 1442 RDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRC---DGHQDCQ 1498
DC DG DE L C + C T + N RC DG + +
Sbjct: 101 LDCPDGYDE----------GVHCQELLSNCQ--QLNCQYKCTMVRNSTRCYCEDGFEITE 148
Query: 1499 DGR---DEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDELTV 1555
DGR D+ C + T + R +C+ +G+L + D ++C ++
Sbjct: 149 DGRSCKDQDECAVYGTCSQTCRNTHGSYTCSCV------EGYL---MQPDNRSCKAKIEP 199
Query: 1556 YKVQNLQWTADFSGDVTLTWMRPKKMPSASCV 1587
+ A+F + + ++ KM + S V
Sbjct: 200 TDRPPILLIANFE-TIEVFYLNGSKMATLSSV 230
Score = 41.2 bits (95), Expect = 0.011
Identities = 64/277 (23%), Positives = 91/277 (32%), Gaps = 47/277 (16%)
Query: 1129 GTCIPLSYK-CDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWS 1187
G I YK DL + C D + E C ++ + ++ +C ++ +G C D
Sbjct: 4160 GVLISHRYKQLDLPNPCLDLACEFLCLLNP------SGATCVCPEGKYLINGT--CND-- 4209
Query: 1188 DEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE-KKCNGFRCPN 1246
D + TCE G CI GD C CE C+ +
Sbjct: 4210 DSLLDDSCKLTCE------NGGRCILNE---KGDLRCHCWPSYSGERCEVNHCSNYCQNG 4260
Query: 1247 GTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGS 1306
GTC+PS P C+ + F N + VC+ C++G
Sbjct: 4261 GTCVPSVLG----------------RPTCSCALGFTGPNCGKT-----VCEDF--CQNGG 4297
Query: 1307 DEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAP 1366
P H + G +CQ VC + D S E C E P
Sbjct: 4298 ---TCIVTAGNQPYCHCQPEYTGDRCQYYVCHHYCVNSESCTIGDDGSVECVCPTRYEGP 4354
Query: 1367 NCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDC 1403
C RC GHCI N+ D +C + C
Sbjct: 4355 KCEVDKCVRCHGGHCIINKDSEDIFCNCTNGKIASSC 4391
Score = 38.1 bits (87), Expect = 0.097
Identities = 33/120 (27%), Positives = 53/120 (44%), Gaps = 3/120 (2%)
Query: 768 SIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVII 827
SI R L + + T + L DY LY+SD +L I+R +GS + VI+
Sbjct: 2343 SIMRSTLTGKNAQVVVSTDILTPNGLTIDYRAEKLYFSDGSLGKIERCEYDGSQ-RHVIV 2401
Query: 828 NSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQE 887
SG T +LA ++W D G + I +N I+ S + +P ++ V +
Sbjct: 2402 KSGPGTFLSLAV--YDNYIFWSDWGRRAILRSNKYTGGDTKILRSDIPHQPMGIIAVAND 2459
>gi|157384998 low density lipoprotein receptor-related protein 4 [Homo
sapiens]
Length = 1905
Score = 275 bits (704), Expect = 3e-73
Identities = 157/419 (37%), Positives = 207/419 (49%), Gaps = 61/419 (14%)
Query: 1121 TQFRCQESG----TCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWV 1176
+ F C S TCIP ++CD ++DCGD+SDE C + C +++C +G CIR SWV
Sbjct: 30 SHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCSPLDFHCDNGKCIRRSWV 89
Query: 1177 CDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE 1236
CDGDNDC D SDE +C CE F C+NG+CI W CDGD DC D SDE C+
Sbjct: 90 CDGDNDCEDDSDEQDCPP--RECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE---QCD 144
Query: 1237 -KKCNG--FRCPNGTCIPSSKHCDGLRDCSDGSDEQHC-----EPLCTHFMDFVCKNRQQ 1288
+KC+ FRC +G+CI +CDG DC DGSDE++C P C + +F C +
Sbjct: 145 MRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAVPAPPC-NLEEFQCA-YGR 202
Query: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
C+ CDG C D SDE + CS H+ C F C +G+CI+ W+CDG
Sbjct: 203 CILDIYHCDGDDDCGDWSDE----SDCSS----HQPCRSGEFMCDSGLCINAGWRCDGDA 254
Query: 1349 DCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHI 1408
DC D SDE NC C+ QFRC +G C+ W+CD E+DC D SDE++C ++
Sbjct: 255 DCDDQSDERNCTTSM----CTAE-QFRCHSGRCVRLSWRCDGEDDCADNSDEENCENT-- 307
Query: 1409 LPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQL 1468
G C + + C +G C+ +C+G DC D SDE +P Q
Sbjct: 308 ------GSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDE-------------SPQQN 348
Query: 1469 GRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEAC 1527
R E C N Q CQ R C H+ C+D C
Sbjct: 349 CRPRTGEENC--------NVNNGGCAQKCQMVRGAVQCTCHTGYRLTEDGHTCQDVNEC 399
Score = 269 bits (688), Expect = 2e-71
Identities = 150/341 (43%), Positives = 184/341 (53%), Gaps = 36/341 (10%)
Query: 1075 ENTCLRNQYRCSNG-----NCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESG 1129
E C R+ + C+ CI + W CD DNDCGD SDE C C F C ++G
Sbjct: 24 ECACGRSHFTCAVSALGECTCIPAQWQCDGDNDCGDHSDEDGCILPTCS-PLDFHC-DNG 81
Query: 1130 TCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDE 1189
CI S+ CD ++DC D+SDE C +C DE+ C +G CIRS W CDGDNDC D SDE
Sbjct: 82 KCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDE 141
Query: 1190 ANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEK-----KCN--GF 1242
C C F+C +G CI + W CDGDTDC+DGSDE+ NC CN F
Sbjct: 142 -QCD--MRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEE--NCPSAVPAPPCNLEEF 196
Query: 1243 RCPNGTCIPSSKHCDGLRDCSDGSDEQHC---EPLCTHFMDFVCKNRQQCLFHSMVCDGI 1299
+C G CI HCDG DC D SDE C +P + +F+C + C+ CDG
Sbjct: 197 QCAYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSG--EFMC-DSGLCINAGWRCDGD 253
Query: 1300 IQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
C D SDE C+ +C F+C +G C+ L W+CDG DDC D SDE NC
Sbjct: 254 ADCDDQSDE----RNCTT-----SMCTAEQFRCHSGRCVRLSWRCDGEDDCADNSDEENC 304
Query: 1360 ENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
EN T +P C+ QF C NG CI R C+ NDCGD SDE
Sbjct: 305 EN-TGSPQCA-LDQFLCWNGRCIGQRKLCNGVNDCGDNSDE 343
Score = 243 bits (619), Expect = 2e-63
Identities = 143/363 (39%), Positives = 171/363 (47%), Gaps = 44/363 (12%)
Query: 1187 SDEANCTAIYHTCEASNF-QCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCN--GFR 1243
S E C + TC S +C CIP +W CDGD DC D SDED C+ F
Sbjct: 22 SPECACGRSHFTCAVSALGECT---CIPAQWQCDGDNDCGDHSDEDGCILPT-CSPLDFH 77
Query: 1244 CPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCR 1303
C NG CI S CDG DC D SDEQ C P +F C+N C+ CDG C
Sbjct: 78 CDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFPCQNGY-CIRSLWHCDGDNDCG 136
Query: 1304 DGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPT 1363
D SDE CS D EF +C +G CI+ W CDG DC D SDE NC +
Sbjct: 137 DNSDEQCDMRKCS-DKEF---------RCSDGSCIAEHWYCDGDTDCKDGSDEENCPSAV 186
Query: 1364 EAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNY 1423
AP C+ +F+C G CI + + CD ++DCGDWSDE DC SH C
Sbjct: 187 PAPPCNLE-EFQCAYGRCILDIYHCDGDDDCGDWSDESDCS-SH---------QPCRSGE 235
Query: 1424 YRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKT 1483
+ C SG C+ W CDG DC D SDE C C +F CH +
Sbjct: 236 FMCDSGLCINAGWRCDGDADCDDQSDERNCTT-------------SMCTAEQFRCHSGRC 282
Query: 1484 CIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDE 1543
+W RCDG DC D DE NC + C +F C +G CI + C+G DC D
Sbjct: 283 VRLSW-RCDGEDDCADNSDEENCENTGSPQCALDQFLCWNGR-CIGQRKLCNGVNDCGDN 340
Query: 1544 SDE 1546
SDE
Sbjct: 341 SDE 343
Score = 215 bits (547), Expect = 4e-55
Identities = 128/358 (35%), Positives = 195/358 (54%), Gaps = 42/358 (11%)
Query: 698 VCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEE 757
+C+P SG++Y+ CP G +RKIS C+
Sbjct: 712 LCLP----SGQNYT--CACPTG--------FRKISSHACA-----------------QSL 740
Query: 758 NEFILYAVRKSIYR--YDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRL 815
++F+L+A R I R +D + + +PL +R+AVALD+D + +YW+D++ D I R
Sbjct: 741 DKFLLFARRMDIRRISFDTEDLSDDVIPLADVRSAVALDWDSRDDHVYWTDVSTDTISRA 800
Query: 816 CLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVL 875
+G TGQEV++++ LE+ LA + ++ LYW DAG +IEVAN DG R ++ + L
Sbjct: 801 KWDG-TGQEVVVDTSLESPAGLAIDWVTNKLYWTDAGTDRIEVANTDGSMRTVLIWEN-L 858
Query: 876 DRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWI 933
DRPR +V+ P G M+WTDWG P I R+ MD S ++S ++ WPNG+++D Q +
Sbjct: 859 DRPRDIVVEPMGGYMYWTDWG-ASPKIERAGMDASGRQVIISSNLTWPNGLAIDYGSQRL 917
Query: 934 YWTDAYLECIERITFSGQQRSVILDN-LPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGS 992
YW DA ++ IE G +R V++ + LPHP+ + ++ IYW DW SI A + +G
Sbjct: 918 YWADAGMKTIEFAGLDGSKRKVLIGSQLPHPFGLTLYGERIYWTDWQTKSIQSADRLTGL 977
Query: 993 QMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSR-SCRCPEDVS 1047
E L L LMD+ +F++ + S C CS LCL N S SC CP ++
Sbjct: 978 DRETLQENLENLMDIHVFHRRRPPVSTPCAMENGGCSHLCLRSPNPSGFSCTCPTGIN 1035
Score = 213 bits (543), Expect = 1e-54
Identities = 124/305 (40%), Positives = 157/305 (51%), Gaps = 42/305 (13%)
Query: 1248 TCIPSSKHCDGLRDCSDGSDEQHCE-PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGS 1306
TCIP+ CDG DC D SDE C P C+ +DF C N + C+ S VCDG C D S
Sbjct: 43 TCIPAQWQCDGDNDCGDHSDEDGCILPTCSP-LDFHCDNGK-CIRRSWVCDGDNDCEDDS 100
Query: 1307 DEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAP 1366
DE C + C+E F CQNG CI +W CDG +DCGD SDE +
Sbjct: 101 DEQ----DCPP-----RECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ-----CDMR 146
Query: 1367 NCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRC 1426
CS +FRC +G CI W CD + DC D SDE++C P + P P C ++C
Sbjct: 147 KCSDK-EFRCSDGSCIAEHWYCDGDTDCKDGSDEENC------PSAVPAPP-CNLEEFQC 198
Query: 1427 SSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIP 1486
+ G C++D + CDG DC D SDE C ++ P + G EF C
Sbjct: 199 AYGRCILDIYHCDGDDDCGDWSDESDC-------SSHQPCRSG-----EFMCDSGLCINA 246
Query: 1487 NWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDE 1546
W RCDG DC D DE NC +T C + +F+C G C+ LS RCDG DC+D SDE
Sbjct: 247 GW-RCDGDADCDDQSDERNC---TTSMCTAEQFRCHSGR-CVRLSWRCDGEDDCADNSDE 301
Query: 1547 KACSD 1551
+ C +
Sbjct: 302 ENCEN 306
Score = 207 bits (528), Expect = 7e-53
Identities = 119/301 (39%), Positives = 156/301 (51%), Gaps = 47/301 (15%)
Query: 1013 GKNTGSNACVPRPCSLLCLPKANNSRSCR----------CPEDVSSSVLPSGDLMCD--- 1059
G ++ + C+ CS L +N + R C +D P + D
Sbjct: 58 GDHSDEDGCILPTCSPLDF-HCDNGKCIRRSWVCDGDNDCEDDSDEQDCPPRECEEDEFP 116
Query: 1060 CPQGYQLKNNTCVKEENTCLRN-------------QYRCSNGNCINSIWWCDFDNDCGDM 1106
C GY +++ +N C N ++RCS+G+CI W+CD D DC D
Sbjct: 117 CQNGYCIRSLWHCDGDNDCGDNSDEQCDMRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDG 176
Query: 1107 SDERNCPTTI----CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQ-CRSD 1161
SDE NCP+ + C+L+ +F+C G CI Y CD +DDCGD SDES C HQ CRS
Sbjct: 177 SDEENCPSAVPAPPCNLE-EFQC-AYGRCILDIYHCDGDDDCGDWSDESDCSSHQPCRSG 234
Query: 1162 EYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGD 1221
E+ C SG+CI + W CDGD DC D SDE NCT C A F+C +G C+ W CDG+
Sbjct: 235 EFMCDSGLCINAGWRCDGDADCDDQSDERNCTT--SMCTAEQFRCHSGRCVRLSWRCDGE 292
Query: 1222 TDCQDGSDEDPVNCEK----KC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDE---QHCE 1272
DC D SDE+ NCE +C + F C NG CI K C+G+ DC D SDE Q+C
Sbjct: 293 DDCADNSDEE--NCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQNCR 350
Query: 1273 P 1273
P
Sbjct: 351 P 351
Score = 206 bits (523), Expect = 3e-52
Identities = 117/311 (37%), Positives = 184/311 (59%), Gaps = 11/311 (3%)
Query: 744 RLEGELVPCPLAEENEFILYAVRKSIYRYDL-ASGATE-QLPLTGLRAAVALDFDYEHNC 801
+L+G+ C + E ++L++ R SI R L S T+ +P+ L ++LD+D
Sbjct: 1340 QLKGDGKTCDPSPET-YLLFSSRGSIRRISLDTSDHTDVHVPVPELNNVISLDYDSVDGK 1398
Query: 802 LYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANP 861
+Y++D+ LDVI+R LNGS E +I GL+T + LA + +++ LYW D G IE +
Sbjct: 1399 VYYTDVFLDVIRRADLNGSN-METVIGRGLKTTDGLAVDWVARNLYWTDTGRNTIEASRL 1457
Query: 862 DGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVK 921
DG R ++N+S LD PRA+ + P++G +FWTDWG + I R+N+DGS L++ D+
Sbjct: 1458 DGSCRKVLINNS-LDEPRAIAVFPRKGYLFWTDWGHIAK-IERANLDGSERKVLINTDLG 1515
Query: 922 WPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWS 979
WPNG+++D + IYW DA+L+ IE +G+ R V++ ++ HP+A+ IYW DW
Sbjct: 1516 WPNGLTLDYDTRRIYWVDAHLDRIESADLNGKLRQVLVSHVSHPFALTQQDRWIYWTDWQ 1575
Query: 980 QLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNS 1037
SI R KYSG E + + GLMD+ + + TG+NAC C+ LC +A++
Sbjct: 1576 TKSIQRVDKYSGRNKETVLANVEGLMDIIVVSPQRQTGTNACGVNNGGCTHLCFARASDF 1635
Query: 1038 RSCRCPEDVSS 1048
C CP++ S
Sbjct: 1636 -VCACPDEPDS 1645
Score = 196 bits (498), Expect = 2e-49
Identities = 117/298 (39%), Positives = 166/298 (55%), Gaps = 11/298 (3%)
Query: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811
C +L+A R I R L + L L L A+ALDF + ++WSD+ LD
Sbjct: 433 CKALGPEPVLLFANRIDI-RQVLPHRSEYTLLLNNLENAIALDFHHRRELVFWSDVTLDR 491
Query: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
I R LNGS +EV+ ++GLE+ LA + + LYW D+G +IEVAN DG R ++
Sbjct: 492 ILRANLNGSNVEEVV-STGLESPGGLAVDWVHDKLYWTDSGTSRIEVANLDGAHRKVLLW 550
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
+ L++PRA+ L P EG ++WTDWG+ P I S+MDGS + + WPNG+++D
Sbjct: 551 QN-LEKPRAIALHPMEGTIYWTDWGNT-PRIEASSMDGSGRRIIADTHLFWPNGLTIDYA 608
Query: 930 DQWIYWTDAYLECIERITFSGQQR-SVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
+ +YW DA IER G R +VI LPHP+AI VF++ +YW DW SI A+K
Sbjct: 609 GRRMYWVDAKHHVIERANLDGSHRKAVISQGLPHPFAITVFEDSLYWTDWHTKSINSANK 668
Query: 989 YSGSQMEILANQLTGLMDMKIFYKGKN-TGSNACVPR--PCSLLCLPKANNSRSCRCP 1043
++G EI+ N+L MD+ + + G N C C+ LCLP N +C CP
Sbjct: 669 FTGKNQEIIRNKLHFPMDIHTLHPQRQPAGKNRCGDNNGGCTHLCLPSGQN-YTCACP 725
Score = 193 bits (490), Expect = 2e-48
Identities = 132/391 (33%), Positives = 190/391 (48%), Gaps = 59/391 (15%)
Query: 698 VCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARLEGELVPCPLAEE 757
+C+ P SG S + CP G G TCS G
Sbjct: 1016 LCLRSPNPSGFSCT----CPTGINLLS-------DGKTCSPG-----------------M 1047
Query: 758 NEFILYAVRKSI--YRYDLASGATEQLPLT-GLRAAVALDFDYEHNCLYWSDLALDVIQR 814
N F+++A R I D+ A +P+ ++ +A+ D + +YWSD L I R
Sbjct: 1048 NSFLIFARRIDIRMVSLDIPYFADVVVPINITMKNTIAIGVDPQEGKVYWSDSTLHRISR 1107
Query: 815 LCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSV 874
L+GS ++ II +GL+T + LA + + + +YW D G +IEV N DG R +V +
Sbjct: 1108 ANLDGSQHED-IITTGLQTTDGLAVDAIGRKVYWTDTGTNRIEVGNLDGSMRKVLVWQN- 1165
Query: 875 LDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQW 932
LD PRA+VL + G M+WTDWG+ + RS MDGS L++ ++ WPNG++VD
Sbjct: 1166 LDSPRAIVLYHEMGFMYWTDWGE-NAKLERSGMDGSDRAVLINNNLGWPNGLTVDKASSQ 1224
Query: 933 IYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGS 992
+ W DA+ E IE +G R ++ + HPY + + + IYW DW SI RA K +GS
Sbjct: 1225 LLWADAHTERIEAADLNGANRHTLVSPVQHPYGLTLLDSYIYWTDWQTRSIHRADKGTGS 1284
Query: 993 QMEILANQLTGLMDMKIFYKGKNTGSNACVPRP--CSLLCLPKANNSRSCRCPEDVSSSV 1050
+ ++ + L GLMDM+ + + G N C R CS LCLP+
Sbjct: 1285 NVILVRSNLPGLMDMQAVDRAQPLGFNKCGSRNGGCSHLCLPR----------------- 1327
Query: 1051 LPSGDLMCDCPQGYQLKNN--TCVKEENTCL 1079
PSG C CP G QLK + TC T L
Sbjct: 1328 -PSG-FSCACPTGIQLKGDGKTCDPSPETYL 1356
Score = 189 bits (479), Expect = 3e-47
Identities = 106/265 (40%), Positives = 132/265 (49%), Gaps = 39/265 (14%)
Query: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
C+ CDG C D SDED GC C F C NG CI W CDG +
Sbjct: 44 CIPAQWQCDGDNDCGDHSDED----GC-----ILPTCSPLDFHCDNGKCIRRSWVCDGDN 94
Query: 1349 DCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHI 1408
DC D SDE +C P +F C+NG+CI + W CD +NDCGD SDE+ C
Sbjct: 95 DCEDDSDEQDCP-----PRECEEDEFPCQNGYCIRSLWHCDGDNDCGDNSDEQ-CD---- 144
Query: 1409 LPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQL 1468
C +RCS G+C+ + W CDG DC DGSDEE CP +A P
Sbjct: 145 -------MRKCSDKEFRCSDGSCIAEHWYCDGDTDCKDGSDEENCP-----SAVPAPP-- 190
Query: 1469 GRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACI 1528
C+ EF+C + CI + CDG DC D DE++C +H C S EF C+ G CI
Sbjct: 191 --CNLEEFQCAYGR-CILDIYHCDGDDDCGDWSDESDCSSHQP--CRSGEFMCDSG-LCI 244
Query: 1529 VLSERCDGFLDCSDESDEKACSDEL 1553
RCDG DC D+SDE+ C+ +
Sbjct: 245 NAGWRCDGDADCDDQSDERNCTTSM 269
Score = 131 bits (329), Expect = 8e-30
Identities = 74/204 (36%), Positives = 99/204 (48%), Gaps = 27/204 (13%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
C ++ C +G CIN+ W CD D DC D SDERNC T++C + QFRC SG C+ LS++
Sbjct: 231 CRSGEFMCDSGLCINAGWRCDGDADCDDQSDERNCTTSMCTAE-QFRC-HSGRCVRLSWR 288
Query: 1138 CDLEDDCGDNSDESHCE---MHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTA 1194
CD EDDC DNSDE +CE QC D++ C +G CI +C+G NDC D SDE+
Sbjct: 289 CDGEDDCADNSDEENCENTGSPQCALDQFLCWNGRCIGQRKLCNGVNDCGDNSDESPQQN 348
Query: 1195 IYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSK 1254
N NG C + G C C G +
Sbjct: 349 CRPRTGEENCNVNNGGCAQKCQMVRGAVQC------------------TCHTGYRLTEDG 390
Query: 1255 H-CDGLRDCSDGSDEQHCEPLCTH 1277
H C + +C ++E +C CT+
Sbjct: 391 HTCQDVNEC---AEEGYCSQGCTN 411
>gi|170014689 VPS10 domain receptor protein SORCS 2 [Homo sapiens]
Length = 1159
Score = 260 bits (665), Expect = 9e-69
Identities = 189/673 (28%), Positives = 315/673 (46%), Gaps = 60/673 (8%)
Query: 101 SHNQMVVHWAGEKSNVIVALARDSLA-LARPKSSDVYVSYDYGKSFKKISDKLNFGLGNR 159
+HNQ +VHW GE S+VI+ L + A + + S ++ S D+G S+ K++ L
Sbjct: 146 THNQAMVHWTGENSSVILILTKYYHADMGKVLESSLWRSSDFGTSYTKLT------LQPG 199
Query: 160 SEAVIAQFYHSPADNKRYIFADAYA----QYLWITFDFCNTLQGFSIPFRAADLLLHSKA 215
VI FY P + ++ I + Q L+++ D T Q IPF L+ H K
Sbjct: 200 VTTVIDNFYICPTNKRKVILVSSSLSDRDQSLFLSADEGATFQKQPIPFFVETLIFHPKE 259
Query: 216 SNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHVKS--FSWGIDPYDK-PNTIYIERHEPS 272
+ +L + + +L+ S D G+ W ++QE V W + D P+ +++E +
Sbjct: 260 EDKVLAYTKE---SKLYVSSDLGKKWTLLQERVTKDHVFWSVSGVDADPDLVHVEAQDLG 316
Query: 273 GYSTVFRSTDFFQSRENQEVILEEVR------DFQLRDKYMFATKVVHLLGSEQQSSVQL 326
G FR +++++ ++D Y+F + + +
Sbjct: 317 GD---FRYVTCAIHNCSEKMLTAPFAGPIDHGSLTVQDDYIF-------FKATSANQTKY 366
Query: 327 WVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVS--HSNNRTNLYISEAEGLKFSL 384
+VS+ R + + I E QVFV V + + NLY S+ G++++L
Sbjct: 367 YVSYRRNEFVLMKLPKYALPKDLQIISTDESQVFVAVQEWYQMDTYNLYQSDPRGVRYAL 426
Query: 385 SLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATL-INGSMNEENMRSVIT 443
L++V S A L+ D V G++GV++A I+G + ++IT
Sbjct: 427 VLQDVR--SSRQAEESVLI---------DILEVRGVKGVFLANQKIDGKV-----MTLIT 470
Query: 444 FDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGL 503
++KG W++L+ P+ G+ NC+ C LHL R + + + +K++APGL
Sbjct: 471 YNKGRDWDYLRPPSMDMNGKPTNCK-PPDCHLHLHLRWADNPYVS---GTVHTKDTAPGL 526
Query: 504 IIATGSVGKNLAS-KTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQ-GMETNEL 561
I+ G++G L K +YI+S G WR+ H+ + DHGG+I AI + L
Sbjct: 527 IMGAGNLGSQLVEYKEEMYITSDCGHTWRQVFEEEHHILYLDHGGVIVAIKDTSIPLKIL 586
Query: 562 KYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDAL 621
K+S +EG TW T F+ VFV GLL+EPG+++ V T+FG W +++V+ +
Sbjct: 587 KFSVDEGLTWSTHNFTSTSVFVDGLLSEPGDETLVMTVFGHISFR-SDWELVKVDFRPSF 645
Query: 622 GVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTRED 681
C E DY W S+ +G+ C++G + F++R + C G F + C C D
Sbjct: 646 SRQCGEEDYSSWELSNLQGDRCIMGQQRSFRKRKSTSWCIKGRSFTSALTSRVCECRDSD 705
Query: 682 YECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDV 741
+ CD+GF+ S F SPP C +G TY + GYRK+ + C GG V
Sbjct: 706 FLCDYGFERSSSSESSTNKCSANFWFNPLSPPDDCALGQTYTSSLGYRKVVSNVCEGG-V 764
Query: 742 EARLEGELVPCPL 754
+ + + CPL
Sbjct: 765 DMQQSQVQLQCPL 777
>gi|18379346 VPS10 domain receptor protein SORCS 3 [Homo sapiens]
Length = 1222
Score = 259 bits (663), Expect = 2e-68
Identities = 200/728 (27%), Positives = 347/728 (47%), Gaps = 73/728 (10%)
Query: 33 QRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDARGASRADEKPLRRKRSAALQPEPIKV 92
+R P+ Q+RG P + +R A+G SR + K R SAA
Sbjct: 129 RRSRRAQPPITQERGDAWATA-PADGSRGSRPLAKG-SREEVKAPRAGGSAAEDLRLPST 186
Query: 93 YGQVSLNDSHNQMVVHWAGEKSNVIVALAR-DSLALARPKSSDVYVSYDYGKSFKKISDK 151
++ + +HNQ +VHW+G S+VI+ L + L S ++ S DYG +++K++DK
Sbjct: 187 SFALTGDSAHNQAMVHWSGHNSSVILILTKLYDFNLGSVTESSLWRSTDYGTTYEKLNDK 246
Query: 152 LNFGLGNRSEAVIAQFYHSPADNKRYIFAD--AYAQYLWITFDFCNTLQGFSIPFRAADL 209
+ + V++ Y +P + ++ + + I+ D T Q + + F L
Sbjct: 247 VGL------KTVLSYLYVNPTNKRKIMLLSDPEMESSILISSDEGATYQKYRLTFYIQSL 300
Query: 210 LLHSKASNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHV--KSFSWGIDPYDKP-NTIYI 266
L H K + +L + +++L+ S DFG+ W ++ E + F W + DK + +++
Sbjct: 301 LFHPKQEDWVLAYSL---DQKLYSSMDFGRRWQLMHERITPNRFYWSVAGLDKEADLVHM 357
Query: 267 ERHEPSGYSTVF-----------RSTDFFQSRENQEVILEEVRDFQLRDKYMFATKVVHL 315
E GY+ RS F +S + ++++ D+Y+F + +
Sbjct: 358 EVRTTDGYAHYLTCRIQECAETTRSGPFARSIDISSLVVQ--------DEYIF----IQV 405
Query: 316 LGSEQQSSVQLWVSFGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVS--HSNNRTNLY 373
S + S +VS+ R+ + + +I E+QVF V + N+ NLY
Sbjct: 406 TTSGRAS---YYVSYRREAFAQIKLPKYSLPKDMHIISTDENQVFAAVQEWNQNDTYNLY 462
Query: 374 ISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSM 433
IS+ G+ F+L++EN+ S G + ++ + + V G++G+++A
Sbjct: 463 ISDTRGIYFTLAMENIK--SSRGLMGNIII---------ELYEVAGIKGIFLAN----KK 507
Query: 434 NEENMRSVITFDKGGTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMP 493
++ +++ IT++KG W LQAP G ++C L CSLHL +LS+ R
Sbjct: 508 VDDQVKTYITYNKGRDWRLLQAPDVDLRGSPVHC-LLPFCSLHLHLQLSENPYSSGR--- 563
Query: 494 ILSKESAPGLIIATGSVGKNLA-SKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAI 552
I SKE+APGL++ATG++G L+ + V+ISS G WR+ + + D GG + A+
Sbjct: 564 ISSKETAPGLVVATGNIGPELSYTDIGVFISSDGGNTWRQIFDEEYNVWFLDWGGALVAM 623
Query: 553 AQG-METNELKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWL 611
+ L S +EG +W + F+ P+FV G L E G ++ + T+FG W
Sbjct: 624 KHTPLPVRHLWVSFDEGHSWDKYGFTSVPLFVDGALVEAGMETHIMTVFGHFSLR-SEWQ 682
Query: 612 ILQVNATDALGVPCTENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVV 671
+++V+ CT+ DY+ W ++ G C++G + +FK+R P A C G D VV
Sbjct: 683 LVKVDYKSIFSRHCTKEDYQTWHLLNQ-GEPCVMGERKIFKKRKPGAQCALGRDHSGSVV 741
Query: 672 VSNCSCTREDYECDFGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKI 731
C C D+ECD+G++ + CV P F SP C +G +Y + GYR+I
Sbjct: 742 SEPCVCANWDFECDYGYERHGE---SQCV--PAFWYNPASPSKDCSLGQSYLNSTGYRRI 796
Query: 732 SGDTCSGG 739
+ C+ G
Sbjct: 797 VSNNCTDG 804
>gi|61743975 SORCS receptor 1 isoform b [Homo sapiens]
Length = 1198
Score = 254 bits (648), Expect = 9e-67
Identities = 184/668 (27%), Positives = 330/668 (49%), Gaps = 57/668 (8%)
Query: 99 NDSHNQMVVHWAGEKSNVIVALAR-DSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLG 157
+ +HNQ +VHW+G S+VI+ L + L S ++ S DYG +++K++DK+
Sbjct: 170 DSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGL--- 226
Query: 158 NRSEAVIAQFYHSPADNKRYIFAD--AYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKA 215
+ +++ Y P + ++ + L I+ D T Q + + F LL H K
Sbjct: 227 ---KTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQ 283
Query: 216 SNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHV--KSFSWGIDPYDK-PNTIYIERHEPS 272
+ +L + + +++L+ S +FG+ W +IQE V F W + +K P+ +++E
Sbjct: 284 EDWILAYSQ---DQKLYSSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVD 340
Query: 273 GYSTVF--RSTDFFQSRENQEVI-LEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVS 329
G+S R + ++ NQ + ++D Y+F V L + +VS
Sbjct: 341 GHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVF----VQLTSGGRP---HYYVS 393
Query: 330 FGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVS--HSNNRTNLYISEAEGLKFSLSLE 387
+ R + + ++ E+QVF V + N+ NLYIS+ G+ F+L+LE
Sbjct: 394 YRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTLALE 453
Query: 388 NVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKG 447
NV S G + ++ D + V G++G+++A + +++ IT++KG
Sbjct: 454 NV--QSSRGPEGNIMI---------DLYEVAGIKGMFLAN----KKIDNQVKTFITYNKG 498
Query: 448 GTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIAT 507
W LQAP G+ ++C L CSLHL ++S+ N + I SK++AP +I+A+
Sbjct: 499 RDWRLLQAPDTDLRGDPVHCLLPY-CSLHLHLKVSE--NPYTSGI-IASKDTAPSIIVAS 554
Query: 508 GSVGKNLA-SKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQ-GMETNELKYST 565
G++G L+ + ++++SS AG WR+ H + D GG++ A+ + L S
Sbjct: 555 GNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSF 614
Query: 566 NEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPC 625
+EG +W + F+ P+FV G+L EPGE++ + T+FG + + W +++V+ C
Sbjct: 615 DEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFG-HFSHRSEWQLVKVDYKSIFDRRC 673
Query: 626 TENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECD 685
E DY+ W +G C++G K ++K+R C G+ + + C CT D++CD
Sbjct: 674 AEEDYRPWQ-LHSQGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCD 731
Query: 686 FGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARL 745
+G+ E S C+P F+ S S C +G +Y + GYRK+ + C+ G V +
Sbjct: 732 YGY---ERHSNGQCLPAFWFNPSSLSK--DCSLGQSYLNSTGYRKVVSNNCTDG-VREQY 785
Query: 746 EGELVPCP 753
+ CP
Sbjct: 786 TAKPQKCP 793
>gi|61743973 SORCS receptor 1 isoform a [Homo sapiens]
Length = 1168
Score = 254 bits (648), Expect = 9e-67
Identities = 184/668 (27%), Positives = 330/668 (49%), Gaps = 57/668 (8%)
Query: 99 NDSHNQMVVHWAGEKSNVIVALAR-DSLALARPKSSDVYVSYDYGKSFKKISDKLNFGLG 157
+ +HNQ +VHW+G S+VI+ L + L S ++ S DYG +++K++DK+
Sbjct: 170 DSAHNQAMVHWSGHNSSVILILTKLYDYNLGSITESSLWRSTDYGTTYEKLNDKVGL--- 226
Query: 158 NRSEAVIAQFYHSPADNKRYIFAD--AYAQYLWITFDFCNTLQGFSIPFRAADLLLHSKA 215
+ +++ Y P + ++ + L I+ D T Q + + F LL H K
Sbjct: 227 ---KTILSYLYVCPTNKRKIMLLTDPEIESSLLISSDEGATYQKYRLNFYIQSLLFHPKQ 283
Query: 216 SNLLLGFDRSHPNKQLWKSDDFGQTWIMIQEHV--KSFSWGIDPYDK-PNTIYIERHEPS 272
+ +L + + +++L+ S +FG+ W +IQE V F W + +K P+ +++E
Sbjct: 284 EDWILAYSQ---DQKLYSSAEFGRRWQLIQEGVVPNRFYWSVMGSNKEPDLVHLEARTVD 340
Query: 273 GYSTVF--RSTDFFQSRENQEVI-LEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVS 329
G+S R + ++ NQ + ++D Y+F V L + +VS
Sbjct: 341 GHSHYLTCRMQNCTEANRNQPFPGYIDPDSLIVQDHYVF----VQLTSGGRP---HYYVS 393
Query: 330 FGRKPMRAAQFVTRHPINEYYIADASEDQVFVCVS--HSNNRTNLYISEAEGLKFSLSLE 387
+ R + + ++ E+QVF V + N+ NLYIS+ G+ F+L+LE
Sbjct: 394 YRRNAFAQMKLPKYALPKDMHVISTDENQVFAAVQEWNQNDTYNLYISDTRGVYFTLALE 453
Query: 388 NVLYYSPGGAGSDTLVRYFANEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKG 447
NV S G + ++ D + V G++G+++A + +++ IT++KG
Sbjct: 454 NV--QSSRGPEGNIMI---------DLYEVAGIKGMFLAN----KKIDNQVKTFITYNKG 498
Query: 448 GTWEFLQAPAFTGYGEKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIAT 507
W LQAP G+ ++C L CSLHL ++S+ N + I SK++AP +I+A+
Sbjct: 499 RDWRLLQAPDTDLRGDPVHCLLPY-CSLHLHLKVSE--NPYTSGI-IASKDTAPSIIVAS 554
Query: 508 GSVGKNLA-SKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQ-GMETNELKYST 565
G++G L+ + ++++SS AG WR+ H + D GG++ A+ + L S
Sbjct: 555 GNIGSELSDTDISMFVSSDAGNTWRQIFEEEHSVLYLDQGGVLVAMKHTSLPIRHLWLSF 614
Query: 566 NEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSWLILQVNATDALGVPC 625
+EG +W + F+ P+FV G+L EPGE++ + T+FG + + W +++V+ C
Sbjct: 615 DEGRSWSKYSFTSIPLFVDGVLGEPGEETLIMTVFG-HFSHRSEWQLVKVDYKSIFDRRC 673
Query: 626 TENDYKLWSPSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECD 685
E DY+ W +G C++G K ++K+R C G+ + + C CT D++CD
Sbjct: 674 AEEDYRPWQ-LHSQGEACIMGAKRIYKKRKSERKCMQGK-YAGAMESEPCVCTEADFDCD 731
Query: 686 FGFKMSEDLSLEVCVPDPEFSGKSYSPPVPCPVGSTYRRTRGYRKISGDTCSGGDVEARL 745
+G+ E S C+P F+ S S C +G +Y + GYRK+ + C+ G V +
Sbjct: 732 YGY---ERHSNGQCLPAFWFNPSSLSK--DCSLGQSYLNSTGYRKVVSNNCTDG-VREQY 785
Query: 746 EGELVPCP 753
+ CP
Sbjct: 786 TAKPQKCP 793
>gi|65301164 very low density lipoprotein receptor isoform b [Homo
sapiens]
Length = 845
Score = 252 bits (643), Expect = 3e-66
Identities = 148/407 (36%), Positives = 192/407 (47%), Gaps = 54/407 (13%)
Query: 1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRW 1216
+C ++ C++G CI W CDGD DC D SDE NC + TC S+F C NG C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 1217 ACDGDTDCQDGSDEDPVNCE-KKCNGFRCPNGT----CIPSSKHCDGLRDCSDGSDEQHC 1271
CDGD DC+DGSDE P C + C G CIP S CDG DC G DE++C
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Query: 1272 EPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQ 1331
+ +F C + +C+ + VC+G C DGSDE C+ C FQ
Sbjct: 150 GNITCSPDEFTCSS-GRCISRNFVCNGQDDCSDGSDE----LDCAP-----PTCGAHEFQ 199
Query: 1332 CQNGVCISLIWKCDGMDDCGDYSDEA--NC-ENPTEAPNCSRYFQFRCENGHCIPNRWKC 1388
C CI + W CD DC D SDE+ C P C + +C +G CI +W+C
Sbjct: 200 CSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPA-SEIQCGSGECIHKKWRC 258
Query: 1389 DRENDCGDWSDEKDCGDSHILPFSTPGPS-TCLPNYYRCSSGTCVMDTWVCDGYRDCADG 1447
D + DC D SDE +C PS TC P+ + C G+C+ + C+G RDC DG
Sbjct: 259 DGDPDCKDGSDEVNC------------PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDG 306
Query: 1448 SDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCP 1507
SDE C NV P +F+C + CI K C+ QDC+D DE
Sbjct: 307 SDEVNC---KNVNQCLGPG--------KFKCRSGE-CIDISKVCNQEQDCRDWSDEPLKE 354
Query: 1508 THSTLTCMSREFQCEDGEACIVLSERCD---GFLDCSDESDEKACSD 1551
H C+ C +V+ CD GF + D K C D
Sbjct: 355 CHIN-ECLVNNGGCSHICKDLVIGYECDCAAGF----ELIDRKTCGD 396
Score = 247 bits (630), Expect = 1e-64
Identities = 145/366 (39%), Positives = 190/366 (51%), Gaps = 46/366 (12%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
C +Q++C+NG CI +W CD D DC D SDE+NC C ++ F C +G C+P +K
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTC-AESDFVC-NNGQCVPSRWK 90
Query: 1138 CDLEDDCGDNSDES--HCEMHQCRSDEYNCS--SGMCIRSSWVCDGDNDCRDWSDEANCT 1193
CD + DC D SDES C M CR E +C S CI SW CDG+NDC DE NC
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
Query: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---FRCPNGTCI 1250
I TC F C +G CI + + C+G DC DGSDE ++C G F+C +CI
Sbjct: 151 NI--TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCI 206
Query: 1251 PSSKHCDGLRDCSDGSDE--QHC--EPLC---THFMDFVCKNRQQCLFHSMVCDGIIQCR 1303
P S CD DCSD SDE + C +P+ + C +C+ CDG C+
Sbjct: 207 PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQC-GSGECIHKKWRCDGDPDCK 265
Query: 1304 DGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPT 1363
DGSDE C + C F+C++G CI +C+G+ DC D SDE NC+N
Sbjct: 266 DGSDE----VNCPS-----RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1364 EAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE--KDCGDSHILPFSTPGPSTCLP 1421
+ C +F+C +G CI C++E DC DWSDE K+C HI + CL
Sbjct: 317 Q---CLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC---HI--------NECLV 362
Query: 1422 NYYRCS 1427
N CS
Sbjct: 363 NNGGCS 368
Score = 246 bits (628), Expect = 2e-64
Identities = 131/334 (39%), Positives = 171/334 (51%), Gaps = 23/334 (6%)
Query: 1121 TQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGD 1180
+QF+C +G CI L +KCD ++DC D SDE +C C ++ C++G C+ S W CDGD
Sbjct: 36 SQFQCT-NGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGD 94
Query: 1181 NDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQRWACDGDTDCQDGSDEDPV-NCEK 1237
DC D SDE+ TC C + CIP W CDG+ DC G DE+ N
Sbjct: 95 PDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITC 154
Query: 1238 KCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCD 1297
+ F C +G CI + C+G DCSDGSDE C P +F C + C+ S VCD
Sbjct: 155 SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC-STSSCIPISWVCD 213
Query: 1298 GIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEA 1357
C D SDE + C + P H C QC +G CI W+CDG DC D SDE
Sbjct: 214 DDADCSDQSDE--SLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV 271
Query: 1358 NCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPS 1417
NC + T P+ QF CE+G CI +C+ DC D SDE +C +
Sbjct: 272 NCPSRTCRPD-----QFECEDGSCIHGSRQCNGIRDCVDGSDEVNC----------KNVN 316
Query: 1418 TCL-PNYYRCSSGTCVMDTWVCDGYRDCADGSDE 1450
CL P ++C SG C+ + VC+ +DC D SDE
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 224 bits (572), Expect = 6e-58
Identities = 135/369 (36%), Positives = 171/369 (46%), Gaps = 51/369 (13%)
Query: 1059 DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE--RNCPTTI 1116
DC G KN CVK+ TC + + C+NG C+ S W CD D DC D SDE C
Sbjct: 57 DCVDGSDEKN--CVKK--TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRT 112
Query: 1117 CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWV 1176
C + S CIP+S++CD E+DC DE +C C DE+ CSSG CI ++V
Sbjct: 113 CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFV 172
Query: 1177 CDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE 1236
C+G +DC D SDE +C TC A FQC CIP W CD D DC D SDE C
Sbjct: 173 CNGQDDCSDGSDELDCAP--PTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCG 230
Query: 1237 K------KC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQ 1288
+ KC + +C +G CI CDG DC DGSDE +C F C++
Sbjct: 231 RQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECED-GS 289
Query: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
C+ S C+GI C DGSDE C ++ F+C++G CI + C+
Sbjct: 290 CIHGSRQCNGIRDCVDGSDE----VNCK---NVNQCLGPGKFKCRSGECIDISKVCNQEQ 342
Query: 1349 DCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDR---------ENDCG---D 1396
DC D+SDE E C C+ N C E DC +
Sbjct: 343 DCRDWSDEPLKE---------------CHINECLVNNGGCSHICKDLVIGYECDCAAGFE 387
Query: 1397 WSDEKDCGD 1405
D K CGD
Sbjct: 388 LIDRKTCGD 396
Score = 154 bits (388), Expect = 1e-36
Identities = 94/328 (28%), Positives = 159/328 (48%), Gaps = 26/328 (7%)
Query: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811
C + +++ R+ I + L QL + LR VALD D L+W+DL+
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKEYIQL-VEQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
I ++ G+ V + + A+A + + + +YW DA K I VA DG R + N
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFN 552
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
S L P ++ + P G ++W+DWG+ I ++ M+G LV+ D++WPNGI++D
Sbjct: 553 SD-LREPASIAVDPLSGFVYWSDWGE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 930 DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHPYAIAVFKNEIYWDDWSQLSIFRA 986
+YW D+ L + + +GQ R ++L + L HP A+ +F++ +YW D +++ A
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGA 670
Query: 987 SKYSGSQMEILANQLTGLMDMKIFYK-----GKNTGSNACVPRPCSLLCLPKANNSRSCR 1041
+K++GS++ L N L D+ ++++ GKN C LCLP +
Sbjct: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDH-- 728
Query: 1042 CPEDVSSSVLPSGDLMCDCPQGYQLKNN 1069
S C CP GY ++ N
Sbjct: 729 -----------SPKYTCSCPSGYNVEEN 745
Score = 65.9 bits (159), Expect = 4e-10
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 5/106 (4%)
Query: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIV 1529
+C+ +F+C + WK CDG +DC DG DE NC TC +F C +G+ C+
Sbjct: 32 KCEPSQFQCTNGRCITLLWK-CDGDEDCVDGSDEKNCVKK---TCAESDFVCNNGQ-CVP 86
Query: 1530 LSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTW 1575
+CDG DC D SDE + ++ + A + + ++W
Sbjct: 87 SRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSW 132
>gi|65301167 very low density lipoprotein receptor isoform a [Homo
sapiens]
Length = 873
Score = 252 bits (643), Expect = 3e-66
Identities = 148/407 (36%), Positives = 192/407 (47%), Gaps = 54/407 (13%)
Query: 1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRW 1216
+C ++ C++G CI W CDGD DC D SDE NC + TC S+F C NG C+P RW
Sbjct: 32 KCEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNC--VKKTCAESDFVCNNGQCVPSRW 89
Query: 1217 ACDGDTDCQDGSDEDPVNCE-KKCNGFRCPNGT----CIPSSKHCDGLRDCSDGSDEQHC 1271
CDGD DC+DGSDE P C + C G CIP S CDG DC G DE++C
Sbjct: 90 KCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENC 149
Query: 1272 EPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQ 1331
+ +F C + +C+ + VC+G C DGSDE C+ C FQ
Sbjct: 150 GNITCSPDEFTCSS-GRCISRNFVCNGQDDCSDGSDE----LDCAP-----PTCGAHEFQ 199
Query: 1332 CQNGVCISLIWKCDGMDDCGDYSDEA--NC-ENPTEAPNCSRYFQFRCENGHCIPNRWKC 1388
C CI + W CD DC D SDE+ C P C + +C +G CI +W+C
Sbjct: 200 CSTSSCIPISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPA-SEIQCGSGECIHKKWRC 258
Query: 1389 DRENDCGDWSDEKDCGDSHILPFSTPGPS-TCLPNYYRCSSGTCVMDTWVCDGYRDCADG 1447
D + DC D SDE +C PS TC P+ + C G+C+ + C+G RDC DG
Sbjct: 259 DGDPDCKDGSDEVNC------------PSRTCRPDQFECEDGSCIHGSRQCNGIRDCVDG 306
Query: 1448 SDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCP 1507
SDE C NV P +F+C + CI K C+ QDC+D DE
Sbjct: 307 SDEVNC---KNVNQCLGPG--------KFKCRSGE-CIDISKVCNQEQDCRDWSDEPLKE 354
Query: 1508 THSTLTCMSREFQCEDGEACIVLSERCD---GFLDCSDESDEKACSD 1551
H C+ C +V+ CD GF + D K C D
Sbjct: 355 CHIN-ECLVNNGGCSHICKDLVIGYECDCAAGF----ELIDRKTCGD 396
Score = 247 bits (630), Expect = 1e-64
Identities = 145/366 (39%), Positives = 190/366 (51%), Gaps = 46/366 (12%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
C +Q++C+NG CI +W CD D DC D SDE+NC C ++ F C +G C+P +K
Sbjct: 33 CEPSQFQCTNGRCITLLWKCDGDEDCVDGSDEKNCVKKTC-AESDFVC-NNGQCVPSRWK 90
Query: 1138 CDLEDDCGDNSDES--HCEMHQCRSDEYNCS--SGMCIRSSWVCDGDNDCRDWSDEANCT 1193
CD + DC D SDES C M CR E +C S CI SW CDG+NDC DE NC
Sbjct: 91 CDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCG 150
Query: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---FRCPNGTCI 1250
I TC F C +G CI + + C+G DC DGSDE ++C G F+C +CI
Sbjct: 151 NI--TCSPDEFTCSSGRCISRNFVCNGQDDCSDGSDE--LDCAPPTCGAHEFQCSTSSCI 206
Query: 1251 PSSKHCDGLRDCSDGSDE--QHC--EPLC---THFMDFVCKNRQQCLFHSMVCDGIIQCR 1303
P S CD DCSD SDE + C +P+ + C +C+ CDG C+
Sbjct: 207 PISWVCDDDADCSDQSDESLEQCGRQPVIHTKCPASEIQC-GSGECIHKKWRCDGDPDCK 265
Query: 1304 DGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPT 1363
DGSDE C + C F+C++G CI +C+G+ DC D SDE NC+N
Sbjct: 266 DGSDE----VNCPS-----RTCRPDQFECEDGSCIHGSRQCNGIRDCVDGSDEVNCKNVN 316
Query: 1364 EAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE--KDCGDSHILPFSTPGPSTCLP 1421
+ C +F+C +G CI C++E DC DWSDE K+C HI + CL
Sbjct: 317 Q---CLGPGKFKCRSGECIDISKVCNQEQDCRDWSDEPLKEC---HI--------NECLV 362
Query: 1422 NYYRCS 1427
N CS
Sbjct: 363 NNGGCS 368
Score = 246 bits (628), Expect = 2e-64
Identities = 131/334 (39%), Positives = 171/334 (51%), Gaps = 23/334 (6%)
Query: 1121 TQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGD 1180
+QF+C +G CI L +KCD ++DC D SDE +C C ++ C++G C+ S W CDGD
Sbjct: 36 SQFQCT-NGRCITLLWKCDGDEDCVDGSDEKNCVKKTCAESDFVCNNGQCVPSRWKCDGD 94
Query: 1181 NDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQRWACDGDTDCQDGSDEDPV-NCEK 1237
DC D SDE+ TC C + CIP W CDG+ DC G DE+ N
Sbjct: 95 PDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITC 154
Query: 1238 KCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCD 1297
+ F C +G CI + C+G DCSDGSDE C P +F C + C+ S VCD
Sbjct: 155 SPDEFTCSSGRCISRNFVCNGQDDCSDGSDELDCAPPTCGAHEFQC-STSSCIPISWVCD 213
Query: 1298 GIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEA 1357
C D SDE + C + P H C QC +G CI W+CDG DC D SDE
Sbjct: 214 DDADCSDQSDE--SLEQCGRQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEV 271
Query: 1358 NCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPS 1417
NC + T P+ QF CE+G CI +C+ DC D SDE +C +
Sbjct: 272 NCPSRTCRPD-----QFECEDGSCIHGSRQCNGIRDCVDGSDEVNC----------KNVN 316
Query: 1418 TCL-PNYYRCSSGTCVMDTWVCDGYRDCADGSDE 1450
CL P ++C SG C+ + VC+ +DC D SDE
Sbjct: 317 QCLGPGKFKCRSGECIDISKVCNQEQDCRDWSDE 350
Score = 224 bits (572), Expect = 6e-58
Identities = 135/369 (36%), Positives = 171/369 (46%), Gaps = 51/369 (13%)
Query: 1059 DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE--RNCPTTI 1116
DC G KN CVK+ TC + + C+NG C+ S W CD D DC D SDE C
Sbjct: 57 DCVDGSDEKN--CVKK--TCAESDFVCNNGQCVPSRWKCDGDPDCEDGSDESPEQCHMRT 112
Query: 1117 CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWV 1176
C + S CIP+S++CD E+DC DE +C C DE+ CSSG CI ++V
Sbjct: 113 CRIHEISCGAHSTQCIPVSWRCDGENDCDSGEDEENCGNITCSPDEFTCSSGRCISRNFV 172
Query: 1177 CDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCE 1236
C+G +DC D SDE +C TC A FQC CIP W CD D DC D SDE C
Sbjct: 173 CNGQDDCSDGSDELDCAP--PTCGAHEFQCSTSSCIPISWVCDDDADCSDQSDESLEQCG 230
Query: 1237 K------KC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQ 1288
+ KC + +C +G CI CDG DC DGSDE +C F C++
Sbjct: 231 RQPVIHTKCPASEIQCGSGECIHKKWRCDGDPDCKDGSDEVNCPSRTCRPDQFECED-GS 289
Query: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
C+ S C+GI C DGSDE C ++ F+C++G CI + C+
Sbjct: 290 CIHGSRQCNGIRDCVDGSDE----VNCK---NVNQCLGPGKFKCRSGECIDISKVCNQEQ 342
Query: 1349 DCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDR---------ENDCG---D 1396
DC D+SDE E C C+ N C E DC +
Sbjct: 343 DCRDWSDEPLKE---------------CHINECLVNNGGCSHICKDLVIGYECDCAAGFE 387
Query: 1397 WSDEKDCGD 1405
D K CGD
Sbjct: 388 LIDRKTCGD 396
Score = 154 bits (388), Expect = 1e-36
Identities = 94/328 (28%), Positives = 159/328 (48%), Gaps = 26/328 (7%)
Query: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811
C + +++ R+ I + L QL + LR VALD D L+W+DL+
Sbjct: 434 CKAVGKEPSLIFTNRRDIRKIGLERKEYIQL-VEQLRNTVALDADIAAQKLFWADLSQKA 492
Query: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
I ++ G+ V + + A+A + + + +YW DA K I VA DG R + N
Sbjct: 493 IFSASIDDKVGRHVKMIDNVYNPAAIAVDWVYKTIYWTDAASKTISVATLDGTKRKFLFN 552
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
S L P ++ + P G ++W+DWG+ I ++ M+G LV+ D++WPNGI++D
Sbjct: 553 SD-LREPASIAVDPLSGFVYWSDWGE-PAKIEKAGMNGFDRRPLVTADIQWPNGITLDLI 610
Query: 930 DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHPYAIAVFKNEIYWDDWSQLSIFRA 986
+YW D+ L + + +GQ R ++L + L HP A+ +F++ +YW D +++ A
Sbjct: 611 KSRLYWLDSKLHMLSSVDLNGQDRRIVLKSLEFLAHPLALTIFEDRVYWIDGENEAVYGA 670
Query: 987 SKYSGSQMEILANQLTGLMDMKIFYK-----GKNTGSNACVPRPCSLLCLPKANNSRSCR 1041
+K++GS++ L N L D+ ++++ GKN C LCLP +
Sbjct: 671 NKFTGSELATLVNNLNDAQDIIVYHELVQPSGKNWCEEDMENGGCEYLCLPAPQINDH-- 728
Query: 1042 CPEDVSSSVLPSGDLMCDCPQGYQLKNN 1069
S C CP GY ++ N
Sbjct: 729 -----------SPKYTCSCPSGYNVEEN 745
Score = 65.9 bits (159), Expect = 4e-10
Identities = 33/106 (31%), Positives = 52/106 (49%), Gaps = 5/106 (4%)
Query: 1470 RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIV 1529
+C+ +F+C + WK CDG +DC DG DE NC TC +F C +G+ C+
Sbjct: 32 KCEPSQFQCTNGRCITLLWK-CDGDEDCVDGSDEKNCVKK---TCAESDFVCNNGQ-CVP 86
Query: 1530 LSERCDGFLDCSDESDEKACSDELTVYKVQNLQWTADFSGDVTLTW 1575
+CDG DC D SDE + ++ + A + + ++W
Sbjct: 87 SRWKCDGDPDCEDGSDESPEQCHMRTCRIHEISCGAHSTQCIPVSW 132
>gi|17149834 sortilin 1 preproprotein [Homo sapiens]
Length = 831
Score = 250 bits (639), Expect = 9e-66
Identities = 224/766 (29%), Positives = 350/766 (45%), Gaps = 100/766 (13%)
Query: 15 LFTLVALLPPGALCEVWTQRLHGGSAPLPQDRGFLVVQGDPRELRLWARGDA--RGASRA 72
L L+ LLPP L + +APLP+ G + V LR A G A RG
Sbjct: 20 LLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWG---LRAAAAGGAFPRGGRWR 76
Query: 73 DEKPLRRKRSAALQPEPIKVYG---QVSLNDSHNQMVVHWAGEKSNVIVALA--RDSLAL 127
P + ++ K+ Q +D + + W G+ + VI+ L L +
Sbjct: 77 RSAPGEDEECGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVI 136
Query: 128 ARPKSSDVYVSYDYGKSFKKISDKLN-------FGLG---NRSEAVIAQFYHSPADNKRY 177
S +Y S DYGK+FK I+D +N FG+ S V+ S
Sbjct: 137 MTFGQSKLYRSEDYGKNFKDITDLINNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGR 196
Query: 178 IFADAYAQYLWITFDFCNTLQGFSIPFRAADLLLHS-KASNLLLGFDRSHPNKQLWKSDD 236
IF + DF +PF +++S + S+ LL + LW S +
Sbjct: 197 IFRSS---------DFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENG---LWVSKN 244
Query: 237 FGQTWIMIQEHVKSFSWGIDPYDKPNTIYIERHEPS------GYSTVFRSTDFFQSRENQ 290
FG W I + V WG D NTI+ + G ++R++D +S +
Sbjct: 245 FGGKWEEIHKAVCLAKWGSD-----NTIFFTTYANGSCKADLGALELWRTSDLGKSFKTI 299
Query: 291 EVILEEVRDFQLRDKYMFATKVVHLLGSEQQSSVQLWVSFGR-KPMRAAQFVTRHPINEY 349
V ++ F L +++FA+ + +++ ++ ++ VS + AQ + Y
Sbjct: 300 GV---KIYSFGLGGRFLFASVM-----ADKDTTRRIHVSTDQGDTWSMAQLPSVGQEQFY 351
Query: 350 YIADASEDQVFVCVSHSNNRT--NLYISEAEGLKFSLSLENVLYYSPGGAGSDTLVRYFA 407
I A++D VF+ V + ++ S+ G+ +S SL+ LY + GG
Sbjct: 352 SILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGGE---------- 401
Query: 408 NEPFADFHRVEGLQGVYIATLINGSMNEENMRSVITFDKGGTWEFLQAPAFTGYGEKINC 467
DF V L+GVYI ++++ + +++++ITFD+GG W L+ P E C
Sbjct: 402 ----TDFTNVTSLRGVYITSVLS---EDNSIQTMITFDQGGRWTHLRKP------ENSEC 448
Query: 468 ELS----QGCSLHL--AQRLSQLLNLQLRRMPILSKESAPGLIIATGSVGKNLASKT-NV 520
+ + CSLH+ + +SQ LN+ M LS+ +A G++IA GSVG ++ +V
Sbjct: 449 DATAKNKNECSLHIHASYSISQKLNVP---MAPLSEPNAVGIVIAHGSVGDAISVMVPDV 505
Query: 521 YISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMET-NELKYSTNEGETWKTFIFSEK 579
YIS G W + L GPHYYT D GGII AI N +K+ST+EG+ W+T+ F+
Sbjct: 506 YISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTYTFTRD 565
Query: 580 PVFVYGLLTEPGEKSTVFTIFGSNKENVHS-WLILQVNATDALGVPCTENDYKLW----S 634
P++ GL +EPG +S +I+G + + S W+ ++ D L C E DY +W +
Sbjct: 566 PIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHST 625
Query: 635 PSDERGNECLLGHKTVFKRRTPHATCFNGEDFDRPVVVSNCSCTREDYECDFGFKMSEDL 694
++ + C+LG+K F R + C NG D+ S C C+ ED+ CDFG+ E+
Sbjct: 626 DPEDYEDGCILGYKEQFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPEND 685
Query: 695 SLEVCVPDPEFSGKSYSPPVPCPVG-STYRRTRGYRKISGDTCSGG 739
S CV PE G C G + T GYRKI GD C GG
Sbjct: 686 S--KCVEQPELKGHDLE---FCLYGREEHLTTNGYRKIPGDKCQGG 726
>gi|4504975 low density lipoprotein receptor precursor [Homo sapiens]
Length = 860
Score = 226 bits (577), Expect = 1e-58
Identities = 138/381 (36%), Positives = 179/381 (46%), Gaps = 37/381 (9%)
Query: 1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQ 1214
+C +E+ C G CI WVCDG +C+D SDE+ T + TC++ +F C R CIPQ
Sbjct: 26 RCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIPQ 85
Query: 1215 RWACDGDTDCQDGSDED---PVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1271
W CDG DC +GSDE P C + + FRC +G CI CD RDC DGSDE C
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQ--DEFRCHDGKCISRQFVCDSDRDCLDGSDEASC 143
Query: 1272 EPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE-DAAFAGCSQDPEFHKVCDEFGF 1330
L F C N C+ CD C DGSDE G C F F
Sbjct: 144 PVLTCGPASFQC-NSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEF 202
Query: 1331 QCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDR 1390
C +G CI W+CDG DC D SDE NC T P+ +F+C +G+CI +CDR
Sbjct: 203 HCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPD-----EFQCSDGNCIHGSRQCDR 257
Query: 1391 ENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDE 1450
E DC D SDE C + + PN ++C SG C+ VC+ RDC D SDE
Sbjct: 258 EYDCKDMSDEVGCVNVTLCEG---------PNKFKCHSGECITLDKVCNMARDCRDWSDE 308
Query: 1451 EACPLLANVTAASTPTQLGRCD--RFEFECHQPKTC-IPNWKRCDGHQDCQDGRDEANCP 1507
N + C+ + +EC P + +RC+ +CQD P
Sbjct: 309 PIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD-------P 361
Query: 1508 THSTLTCMSRE----FQCEDG 1524
+ C++ E QCE+G
Sbjct: 362 DTCSQLCVNLEGGYKCQCEEG 382
Score = 214 bits (545), Expect = 8e-55
Identities = 126/346 (36%), Positives = 169/346 (48%), Gaps = 39/346 (11%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDE--RNCPTTICDLDTQFRCQ-ESGTCIPL 1134
C RN+++C +G CI+ W CD +C D SDE C + C F C CIP
Sbjct: 27 CERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCK-SGDFSCGGRVNRCIPQ 85
Query: 1135 SYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTA 1194
++CD + DC + SDE C C DE+ C G CI +VCD D DC D SDEA+C
Sbjct: 86 FWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPV 145
Query: 1195 IYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC---------EKKCNG--FR 1243
+ TC ++FQC + CIPQ WACD D DC+DGSDE P C C+ F
Sbjct: 146 L--TCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFH 203
Query: 1244 CPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCR 1303
C +G CI SS CDG DC D SDE++C +F C + C+ S CD C+
Sbjct: 204 CLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSD-GNCIHGSRQCDREYDCK 262
Query: 1304 DGSDEDAAFAGCSQDPEFHKVCD-EFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENP 1362
D SDE GC +C+ F+C +G CI+L C+ DC D+SDE E
Sbjct: 263 DMSDE----VGCVN----VTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECG 314
Query: 1363 TEA-----PNCSRY-------FQFRCENGHCIPNRWKCDRENDCGD 1396
T CS ++ C +G + + +C+ ++C D
Sbjct: 315 TNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQD 360
Score = 209 bits (531), Expect = 3e-53
Identities = 137/393 (34%), Positives = 179/393 (45%), Gaps = 61/393 (15%)
Query: 1193 TAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEK---KCNGFRCPN--G 1247
TA+ CE + FQC++G CI +W CDG +CQDGSDE C K F C
Sbjct: 21 TAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVN 80
Query: 1248 TCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
CIP CDG DC +GSDEQ C P +F C + +C+ VCD C DGSD
Sbjct: 81 RCIPQFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHD-GKCISRQFVCDSDRDCLDGSD 139
Query: 1308 EDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDE--ANCEN---- 1361
E A C C FQC + CI +W CD DC D SDE C
Sbjct: 140 E----ASCPV-----LTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVF 190
Query: 1362 PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLP 1421
++ CS F+F C +G CI + W+CD DC D SDE++C +TC P
Sbjct: 191 QGDSSPCSA-FEFHCLSGECIHSSWRCDGGPDCKDKSDEENC-----------AVATCRP 238
Query: 1422 NYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQP 1481
+ ++CS G C+ + CD DC D SDE C NVT P +F+CH
Sbjct: 239 DEFQCSDGNCIHGSRQCDREYDCKDMSDEVGC---VNVTLCEGPN--------KFKCHSG 287
Query: 1482 KTCIPNWKRCDGHQDCQDGRDE--ANCPTHSTL--------TC----MSREFQCEDGEAC 1527
+ CI K C+ +DC+D DE C T+ L C + E C DG
Sbjct: 288 E-CITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQ- 345
Query: 1528 IVLSERCDGFLDCSD-ESDEKACSDELTVYKVQ 1559
+V RC+ +C D ++ + C + YK Q
Sbjct: 346 LVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQ 378
Score = 149 bits (376), Expect = 3e-35
Identities = 97/320 (30%), Positives = 161/320 (50%), Gaps = 22/320 (6%)
Query: 744 RLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLY 803
+L+ C ++ + R + + L L + LR VALD + N +Y
Sbjct: 384 QLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSL-IPNLRNVVALDTEVASNRIY 442
Query: 804 WSDLALDVIQRLCLN---GSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVAN 860
WSDL+ +I L+ G + + +I+ ++ + LA + + +YW D+ + VA+
Sbjct: 443 WSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVAD 502
Query: 861 PDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDV 920
G R T+ + +PRA+V+ P G M+WTDWG I + ++G Y LV+E++
Sbjct: 503 TKGVKRKTLFRENG-SKPRAIVVDPVHGFMYWTDWGT-PAKIKKGGLNGVDIYSLVTENI 560
Query: 921 KWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDN---LPHPYAIAVFKNEIYW 975
+WPNGI++D +YW D+ L I I +G R IL++ L HP+++AVF+++++W
Sbjct: 561 QWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFW 620
Query: 976 DDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYK-GKNTGSNACVPRP-----CSLL 1029
D +IF A++ +GS + +LA L DM +F+ + G N C C L
Sbjct: 621 TDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYL 680
Query: 1030 CLPKAN-NSRS----CRCPE 1044
CLP N S C CP+
Sbjct: 681 CLPAPQINPHSPKFTCACPD 700
Score = 137 bits (346), Expect = 9e-32
Identities = 90/278 (32%), Positives = 125/278 (44%), Gaps = 41/278 (14%)
Query: 1030 CLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGN 1089
C PK + RC + S D DC G + + TC ++C++
Sbjct: 104 CPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVL----TCGPASFQCNSST 159
Query: 1090 CINSIWWCDFDNDCGDMSDE--RNC--------PTTICDLDTQFRCQESGTCIPLSYKCD 1139
CI +W CD D DC D SDE + C ++ C +F C SG CI S++CD
Sbjct: 160 CIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSA-FEFHCL-SGECIHSSWRCD 217
Query: 1140 LEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTC 1199
DC D SDE +C + CR DE+ CS G CI S CD + DC+D SDE C + C
Sbjct: 218 GGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNV-TLC 276
Query: 1200 EASN-FQCRNGHCIPQRWACDGDTDCQDGSDEDPV-------------NCEKKCNGFR-- 1243
E N F+C +G CI C+ DC+D SDE P+ C CN +
Sbjct: 277 EGPNKFKCHSGECITLDKVCNMARDCRDWSDE-PIKECGTNECLDNNGGCSHVCNDLKIG 335
Query: 1244 ----CPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTH 1277
CP+G + + + C+ + +C D C LC +
Sbjct: 336 YECLCPDGFQLVAQRRCEDIDEC---QDPDTCSQLCVN 370
Score = 67.4 bits (163), Expect = 1e-10
Identities = 38/90 (42%), Positives = 50/90 (55%), Gaps = 4/90 (4%)
Query: 1462 ASTPTQLG-RCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQ 1520
A+ T +G RC+R EF+C K W CDG +CQDG DE+ T ++TC S +F
Sbjct: 17 AAAGTAVGDRCERNEFQCQDGKCISYKWV-CDGSAECQDGSDESQ-ETCLSVTCKSGDFS 74
Query: 1521 CEDG-EACIVLSERCDGFLDCSDESDEKAC 1549
C CI RCDG +DC + SDE+ C
Sbjct: 75 CGGRVNRCIPQFWRCDGQVDCDNGSDEQGC 104
>gi|61744471 low density lipoprotein receptor-related protein 8
isoform 1 precursor [Homo sapiens]
Length = 963
Score = 225 bits (573), Expect = 4e-58
Identities = 149/385 (38%), Positives = 179/385 (46%), Gaps = 63/385 (16%)
Query: 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKC---NGFRCPNGTCIPSSKH 1255
CE FQCRN CIP W CD D DC D SDED +C KK + F C NG CI
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWK 104
Query: 1256 CDGLRDCSDGSDEQHCEPLCTHFMDFVCK-----NRQQCLFHSMVCDGIIQCRDGSDEDA 1310
CDG +C DGSDE E CT + K +C+ S CDG C G+DE
Sbjct: 105 CDGEEECPDGSDES--EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE-- 160
Query: 1311 AFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSR 1370
AGC+ +C FQC N C++ ++ CDG DDCGD SDE C +P P
Sbjct: 161 --AGCAT------LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPR--- 209
Query: 1371 YFQFRCEN---GHCIPNRWKCDRENDCGDWSDEKD--CGDSHILPFSTPGPSTCLP-NYY 1424
+FRC G CIP RW CDR+ DC D SDE CG P +T P+ C + +
Sbjct: 210 --EFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPG--PGATSAPAACATASQF 265
Query: 1425 RCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTC 1484
C SG CV W CDG RDC D SDE CP LG C EF+C TC
Sbjct: 266 ACRSGECVHLGWRCDGDRDCKDKSDEADCP-------------LGTCRGDEFQCGD-GTC 311
Query: 1485 IPNWKRCDGHQDCQDGRDEANC------PTHSTLTC------MSREFQCEDGEACIVLSE 1532
+ K C+ QDC DG DEA C H+ C + F+C +L +
Sbjct: 312 VLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQ 371
Query: 1533 RCDGFLDCSDESDEKACSDELTVYK 1557
+ G D + D ACS YK
Sbjct: 372 KTCG--DIDECKDPDACSQICVNYK 394
Score = 210 bits (535), Expect = 1e-53
Identities = 126/368 (34%), Positives = 172/368 (46%), Gaps = 51/368 (13%)
Query: 1113 PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIR 1172
P C+ D QF+C+ CIP ++CD +DDC D+SDE C C ++ C +G CI
Sbjct: 43 PAKDCEKD-QFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
Query: 1173 SSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQRWACDGDTDCQDGSDE 1230
W CDG+ +C D SDE+ T C A C + C+P W CDG+ DC+ G+DE
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
Query: 1231 DPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC-EPLCTHFMDFVC--KN 1285
C C + F+C N +C+ + CDG DC DGSDE+ C +P C +F C
Sbjct: 161 --AGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP-REFRCGGDG 217
Query: 1286 RQQCLFHSMVCDGIIQCRDGSDEDAAFA-----GCSQDPEFHKVCDEFGFQCQNGVCISL 1340
C+ VCD C D SDE A G + P +F C++G C+ L
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFA--CRSGECVHL 275
Query: 1341 IWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
W+CDG DC D SDEA+C T R +F+C +G C+ C++E DC D SDE
Sbjct: 276 GWRCDGDRDCKDKSDEADCPLGT-----CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 330
Query: 1401 KDCGDSHILPFSTPGPSTCLPNYYRCS---------------SGTCVMDTWVCDGYRDCA 1445
C G + CL N CS +G ++D C +C
Sbjct: 331 AGC---------LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC- 380
Query: 1446 DGSDEEAC 1453
D +AC
Sbjct: 381 --KDPDAC 386
Score = 199 bits (506), Expect = 3e-50
Identities = 116/306 (37%), Positives = 151/306 (49%), Gaps = 43/306 (14%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
C ++Q++C N CI S+W CD D+DC D SDE +CP C D+ F C ++G CI +K
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTC-DNGHCIHERWK 104
Query: 1138 CDLEDDCGDNSDESH--CEMHQCRSDEYNC--SSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
CD E++C D SDES C C +++ +C +S C+ +SW CDG+ DC +DEA C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE----DPVNCEKKCNGFRC---PN 1246
+ C FQC N C+ + CDGD DC DGSDE DP ++ FRC
Sbjct: 165 TL---CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPRE---FRCGGDGG 218
Query: 1247 GTCIPSSKHCDGLRDCSDGSDE------------QHCEPLCTHFMDFVCKNRQQCLFHSM 1294
G CIP CD DC D SDE C F C++ +C+
Sbjct: 219 GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRS-GECVHLGW 277
Query: 1295 VCDGIIQCRDGSDE-DAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDY 1353
CDG C+D SDE D C D FQC +G C+ I C+ DC D
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDE----------FQCGDGTCVLAIKHCNQEQDCPDG 327
Query: 1354 SDEANC 1359
SDEA C
Sbjct: 328 SDEAGC 333
Score = 171 bits (432), Expect = 1e-41
Identities = 107/334 (32%), Positives = 146/334 (43%), Gaps = 39/334 (11%)
Query: 1075 ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSD--ERNCPTTICDLDTQFRCQESGTCI 1132
+ TC + + C NG+CI+ W CD + +C D SD E C +C + S C+
Sbjct: 83 KKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
Query: 1133 PLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
P S++CD E DC +DE+ C C E+ C + C+ + +VCDGD+DC D SDE C
Sbjct: 143 PASWRCDGEKDCEGGADEAGCAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Query: 1193 TAIYHTCEASNFQC---RNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG-------- 1241
C F+C G CIP+RW CD DC+D SDE C + G
Sbjct: 202 AD--PACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAAC 259
Query: 1242 -----FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVC 1296
F C +G C+ CDG RDC D SDE C PL T D C+ C
Sbjct: 260 ATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC-PLGTCRGDEFQCGDGTCVLAIKHC 318
Query: 1297 DGIIQCRDGSDEDAAFAGCSQDPEFHKVCD------EFGFQCQNGVCISLIWKCDGMDDC 1350
+ C DGSDE G ++ + C + GF+C L+ C
Sbjct: 319 NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL----DQKTC 374
Query: 1351 GDYSDEANCENPTEAP----NCSRYFQFRCENGH 1380
GD + C++P N YF+ C G+
Sbjct: 375 GDIDE---CKDPDACSQICVNYKGYFKCECYPGY 405
Score = 166 bits (420), Expect = 2e-40
Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 22/309 (7%)
Query: 755 AEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814
A ++ +++ R + R DL +L + L+ VALD + N +YW DL+ I
Sbjct: 418 AGKSPSLIFTNRHEVRRIDLVKRNYSRL-IPMLKNVVALDVEVATNRIYWCDLSYRKIYS 476
Query: 815 LCLNGSTG---QEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
++ ++ QEV+I+ L + E LA + + + +YW D+G K I VA DG R T+ +
Sbjct: 477 AYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 536
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
+ L PRA+ + P G M+W+DWGD + I +S ++G LVS++++WPNGI++D
Sbjct: 537 RN-LSEPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL 594
Query: 930 DQWIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRA 986
Q +YW D+ L + I FSG R ++ D L HP+ IAVF+++++W D +IF A
Sbjct: 595 SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 654
Query: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKN-TGSNAC--VPRP---CSLLCLPKANNSR-- 1038
++ +G ++ ILA L D+ IF++ K +AC +P C LCLP S
Sbjct: 655 NRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 714
Query: 1039 ---SCRCPE 1044
+C CP+
Sbjct: 715 PKYTCACPD 723
Score = 43.1 bits (100), Expect = 0.003
Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 21/108 (19%)
Query: 1039 SCRCPEDVSSSVLPSGDLMC-------DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCI 1091
+CR E V GD C DCP G TC ++++C +G C+
Sbjct: 266 ACRSGECVHLGWRCDGDRDCKDKSDEADCPLG-------------TCRGDEFQCGDGTCV 312
Query: 1092 NSIWWCDFDNDCGDMSDERNCPTTICD-LDTQFRCQESGTCIPLSYKC 1138
+I C+ + DC D SDE C + + L C T + + ++C
Sbjct: 313 LAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
>gi|65301119 low density lipoprotein receptor-related protein 8
isoform 4 precursor [Homo sapiens]
Length = 904
Score = 225 bits (573), Expect = 4e-58
Identities = 149/385 (38%), Positives = 179/385 (46%), Gaps = 63/385 (16%)
Query: 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKC---NGFRCPNGTCIPSSKH 1255
CE FQCRN CIP W CD D DC D SDED +C KK + F C NG CI
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDED--DCPKKTCADSDFTCDNGHCIHERWK 104
Query: 1256 CDGLRDCSDGSDEQHCEPLCTHFMDFVCK-----NRQQCLFHSMVCDGIIQCRDGSDEDA 1310
CDG +C DGSDE E CT + K +C+ S CDG C G+DE
Sbjct: 105 CDGEEECPDGSDES--EATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE-- 160
Query: 1311 AFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSR 1370
AGC+ +C FQC N C++ ++ CDG DDCGD SDE C +P P
Sbjct: 161 --AGCAT------LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPR--- 209
Query: 1371 YFQFRCEN---GHCIPNRWKCDRENDCGDWSDEKD--CGDSHILPFSTPGPSTCLP-NYY 1424
+FRC G CIP RW CDR+ DC D SDE CG P +T P+ C + +
Sbjct: 210 --EFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPG--PGATSAPAACATASQF 265
Query: 1425 RCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTC 1484
C SG CV W CDG RDC D SDE CP LG C EF+C TC
Sbjct: 266 ACRSGECVHLGWRCDGDRDCKDKSDEADCP-------------LGTCRGDEFQCGD-GTC 311
Query: 1485 IPNWKRCDGHQDCQDGRDEANC------PTHSTLTC------MSREFQCEDGEACIVLSE 1532
+ K C+ QDC DG DEA C H+ C + F+C +L +
Sbjct: 312 VLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQ 371
Query: 1533 RCDGFLDCSDESDEKACSDELTVYK 1557
+ G D + D ACS YK
Sbjct: 372 KTCG--DIDECKDPDACSQICVNYK 394
Score = 210 bits (535), Expect = 1e-53
Identities = 126/368 (34%), Positives = 172/368 (46%), Gaps = 51/368 (13%)
Query: 1113 PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIR 1172
P C+ D QF+C+ CIP ++CD +DDC D+SDE C C ++ C +G CI
Sbjct: 43 PAKDCEKD-QFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
Query: 1173 SSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQRWACDGDTDCQDGSDE 1230
W CDG+ +C D SDE+ T C A C + C+P W CDG+ DC+ G+DE
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
Query: 1231 DPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC-EPLCTHFMDFVC--KN 1285
C C + F+C N +C+ + CDG DC DGSDE+ C +P C +F C
Sbjct: 161 --AGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGP-REFRCGGDG 217
Query: 1286 RQQCLFHSMVCDGIIQCRDGSDEDAAFA-----GCSQDPEFHKVCDEFGFQCQNGVCISL 1340
C+ VCD C D SDE A G + P +F C++G C+ L
Sbjct: 218 GGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFA--CRSGECVHL 275
Query: 1341 IWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
W+CDG DC D SDEA+C T R +F+C +G C+ C++E DC D SDE
Sbjct: 276 GWRCDGDRDCKDKSDEADCPLGT-----CRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDE 330
Query: 1401 KDCGDSHILPFSTPGPSTCLPNYYRCS---------------SGTCVMDTWVCDGYRDCA 1445
C G + CL N CS +G ++D C +C
Sbjct: 331 AGC---------LQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDEC- 380
Query: 1446 DGSDEEAC 1453
D +AC
Sbjct: 381 --KDPDAC 386
Score = 199 bits (506), Expect = 3e-50
Identities = 116/306 (37%), Positives = 151/306 (49%), Gaps = 43/306 (14%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
C ++Q++C N CI S+W CD D+DC D SDE +CP C D+ F C ++G CI +K
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTC-DNGHCIHERWK 104
Query: 1138 CDLEDDCGDNSDESH--CEMHQCRSDEYNC--SSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
CD E++C D SDES C C +++ +C +S C+ +SW CDG+ DC +DEA C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE----DPVNCEKKCNGFRC---PN 1246
+ C FQC N C+ + CDGD DC DGSDE DP ++ FRC
Sbjct: 165 TL---CAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPRE---FRCGGDGG 218
Query: 1247 GTCIPSSKHCDGLRDCSDGSDE------------QHCEPLCTHFMDFVCKNRQQCLFHSM 1294
G CIP CD DC D SDE C F C++ +C+
Sbjct: 219 GACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAACATASQFACRS-GECVHLGW 277
Query: 1295 VCDGIIQCRDGSDE-DAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDY 1353
CDG C+D SDE D C D FQC +G C+ I C+ DC D
Sbjct: 278 RCDGDRDCKDKSDEADCPLGTCRGDE----------FQCGDGTCVLAIKHCNQEQDCPDG 327
Query: 1354 SDEANC 1359
SDEA C
Sbjct: 328 SDEAGC 333
Score = 171 bits (432), Expect = 1e-41
Identities = 107/334 (32%), Positives = 146/334 (43%), Gaps = 39/334 (11%)
Query: 1075 ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSD--ERNCPTTICDLDTQFRCQESGTCI 1132
+ TC + + C NG+CI+ W CD + +C D SD E C +C + S C+
Sbjct: 83 KKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
Query: 1133 PLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
P S++CD E DC +DE+ C C E+ C + C+ + +VCDGD+DC D SDE C
Sbjct: 143 PASWRCDGEKDCEGGADEAGCAT-LCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGC 201
Query: 1193 TAIYHTCEASNFQC---RNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG-------- 1241
C F+C G CIP+RW CD DC+D SDE C + G
Sbjct: 202 AD--PACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPGPGATSAPAAC 259
Query: 1242 -----FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVC 1296
F C +G C+ CDG RDC D SDE C PL T D C+ C
Sbjct: 260 ATASQFACRSGECVHLGWRCDGDRDCKDKSDEADC-PLGTCRGDEFQCGDGTCVLAIKHC 318
Query: 1297 DGIIQCRDGSDEDAAFAGCSQDPEFHKVCD------EFGFQCQNGVCISLIWKCDGMDDC 1350
+ C DGSDE G ++ + C + GF+C L+ C
Sbjct: 319 NQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLL----DQKTC 374
Query: 1351 GDYSDEANCENPTEAP----NCSRYFQFRCENGH 1380
GD + C++P N YF+ C G+
Sbjct: 375 GDIDE---CKDPDACSQICVNYKGYFKCECYPGY 405
Score = 166 bits (420), Expect = 2e-40
Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 22/309 (7%)
Query: 755 AEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814
A ++ +++ R + R DL +L + L+ VALD + N +YW DL+ I
Sbjct: 418 AGKSPSLIFTNRHEVRRIDLVKRNYSRL-IPMLKNVVALDVEVATNRIYWCDLSYRKIYS 476
Query: 815 LCLNGSTG---QEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
++ ++ QEV+I+ L + E LA + + + +YW D+G K I VA DG R T+ +
Sbjct: 477 AYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 536
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
+ L PRA+ + P G M+W+DWGD + I +S ++G LVS++++WPNGI++D
Sbjct: 537 RN-LSEPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL 594
Query: 930 DQWIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRA 986
Q +YW D+ L + I FSG R ++ D L HP+ IAVF+++++W D +IF A
Sbjct: 595 SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 654
Query: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKN-TGSNAC--VPRP---CSLLCLPKANNSR-- 1038
++ +G ++ ILA L D+ IF++ K +AC +P C LCLP S
Sbjct: 655 NRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 714
Query: 1039 ---SCRCPE 1044
+C CP+
Sbjct: 715 PKYTCACPD 723
Score = 43.1 bits (100), Expect = 0.003
Identities = 29/108 (26%), Positives = 45/108 (41%), Gaps = 21/108 (19%)
Query: 1039 SCRCPEDVSSSVLPSGDLMC-------DCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCI 1091
+CR E V GD C DCP G TC ++++C +G C+
Sbjct: 266 ACRSGECVHLGWRCDGDRDCKDKSDEADCPLG-------------TCRGDEFQCGDGTCV 312
Query: 1092 NSIWWCDFDNDCGDMSDERNCPTTICD-LDTQFRCQESGTCIPLSYKC 1138
+I C+ + DC D SDE C + + L C T + + ++C
Sbjct: 313 LAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFEC 360
>gi|29244926 corin [Homo sapiens]
Length = 1042
Score = 224 bits (572), Expect = 6e-58
Identities = 159/486 (32%), Positives = 211/486 (43%), Gaps = 102/486 (20%)
Query: 1109 ERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSG 1168
+ N +C F C SG CIP +C+ +DC D SDE+HC C + ++C +G
Sbjct: 261 QENGKQLLCGRGENFLCA-SGICIPGKLQCNGYNDCDDWSDEAHCN---CSENLFHCHTG 316
Query: 1169 MCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGS 1228
C+ S VCDG +DC D SDE NC T +C +G CI W CDGD DC D S
Sbjct: 317 KCLNYSLVCDGYDDCGDLSDEQNCDCNPTT----EHRCGDGRCIAMEWVCDGDHDCVDKS 372
Query: 1229 DEDPVNCEKKCNGF-RCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQ 1287
DE VNC G C NG CIPS+ CDG DC DGSDE++C + T + Q
Sbjct: 373 DE--VNCSCHSQGLVECRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQE----GDQ 426
Query: 1288 QCLFHSMV--CDGIIQCRDGSDEDAAFAGCSQ-DPEFHKVC-----------DEFGFQCQ 1333
+CL++ + C G C D + + CSQ +P ++C + FG + Q
Sbjct: 427 RCLYNPCLDSCGGSSLC----DPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQ 482
Query: 1334 NGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQF--------RCE---NGHCI 1382
IS W E++ NC +Y F +C+ H
Sbjct: 483 KEASIS--W-------------ESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIP 527
Query: 1383 PNRWKCDREND-CG--------DWSDEKDCGDSHILPFSTPGPSTCL----------PNY 1423
P R C+ + C W ++ DC P TCL P++
Sbjct: 528 PCRALCEHSKERCESVLGIVGLQWPEDTDCSQ---FPEENSDNQTCLMPDEYVEECSPSH 584
Query: 1424 YRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKT 1483
++C SG CV+ + CDG DC D SDEE C G +R +EC K
Sbjct: 585 FKCRSGQCVLASRRCDGQADCDDDSDEENC---------------GCKERDLWECPSNKQ 629
Query: 1484 CIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDE 1543
C+ + CDG DC D DE NC C E +C + AC+ CDG DCSD
Sbjct: 630 CLKHTVICDGFPDCPDYMDEKNCS-----FCQDDELECAN-HACVSRDLWCDGEADCSDS 683
Query: 1544 SDEKAC 1549
SDE C
Sbjct: 684 SDEWDC 689
Score = 204 bits (520), Expect = 6e-52
Identities = 156/513 (30%), Positives = 218/513 (42%), Gaps = 101/513 (19%)
Query: 1041 RCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFD 1100
RC + + + + +C PQ K C + EN + C++G CI C+
Sbjct: 239 RCSQFRNQTESSNVSRICFSPQQENGKQLLCGRGEN------FLCASGICIPGKLQCNGY 292
Query: 1101 NDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRS 1160
NDC D SDE +C + + F C +G C+ S CD DDCGD SDE +C+ + +
Sbjct: 293 NDCDDWSDEAHCNCS----ENLFHCH-TGKCLNYSLVCDGYDDCGDLSDEQNCDCNP--T 345
Query: 1161 DEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNF-QCRNGHCIPQRWACD 1219
E+ C G CI WVCDGD+DC D SDE NC+ C + +CRNG CIP + CD
Sbjct: 346 TEHRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS-----CHSQGLVECRNGQCIPSTFQCD 400
Query: 1220 GDTDCQDGSDEDPVNC---EKKCN--GFRCPNGTCIPS---SKHCD---GLRDCSDGSDE 1268
GD DC+DGSDE+ NC + C RC C+ S S CD L +CS
Sbjct: 401 GDEDCKDGSDEE--NCSVIQTSCQEGDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQ---- 454
Query: 1269 QHCEP----LC-------THFMDFVCKNRQQ---CLFHSMVCDGIIQCRDGSDEDAAFAG 1314
CEP LC T + ++ Q+ + S + ++Q + F
Sbjct: 455 --CEPITLELCMNLPYNSTSYPNYFGHRTQKEASISWESSLFPALVQTN--CYKYLMFFS 510
Query: 1315 CS------------QDPEFHKVCDEFGFQCQNGV-CISLIWKCDGMDDCGDY----SDEA 1357
C+ P +C+ +C++ + + L W D DC + SD
Sbjct: 511 CTILVPKCDVNTGEHIPPCRALCEHSKERCESVLGIVGLQWPED--TDCSQFPEENSDNQ 568
Query: 1358 NCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPS 1417
C P E F+C +G C+ +CD + DC D SDE++CG + P
Sbjct: 569 TCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDLWECPSNK 628
Query: 1418 TCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFE 1477
CL + T +CDG+ DC D DE+ C C E E
Sbjct: 629 QCLKH------------TVICDGFPDCPDYMDEKNCSF---------------CQDDELE 661
Query: 1478 CHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHS 1510
C C+ CDG DC D DE +C T S
Sbjct: 662 CAN-HACVSRDLWCDGEADCSDSSDEWDCVTLS 693
Score = 189 bits (479), Expect = 3e-47
Identities = 140/488 (28%), Positives = 206/488 (42%), Gaps = 91/488 (18%)
Query: 1027 SLLCL-PKANNSRSCRCPED----VSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRN 1081
S +C P+ N + C +S + G L C+ GY ++ + C N
Sbjct: 253 SRICFSPQQENGKQLLCGRGENFLCASGICIPGKLQCN---GYNDCDDWSDEAHCNCSEN 309
Query: 1082 QYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLE 1141
+ C G C+N CD +DCGD+SDE+NC C+ T+ RC + G CI + + CD +
Sbjct: 310 LFHCHTGKCLNYSLVCDGYDDCGDLSDEQNCD---CNPTTEHRCGD-GRCIAMEWVCDGD 365
Query: 1142 DDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEA 1201
DC D SDE +C H E C +G CI S++ CDGD DC+D SDE NC+ I +C+
Sbjct: 366 HDCVDKSDEVNCSCHSQGLVE--CRNGQCIPSTFQCDGDEDCKDGSDEENCSVIQTSCQE 423
Query: 1202 SNFQCRNGHCIPQRWA---CDGDTDCQDGSDEDPVNCEKKCN------------GFRCPN 1246
+ +C C+ CD + + S +P+ E N G R
Sbjct: 424 GDQRCLYNPCLDSCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPNYFGHRTQK 483
Query: 1247 GTCIPSSKH------------------CDGLRDCSDGSDEQH---CEPLCTHFMDFVCKN 1285
I C L D + +H C LC H +
Sbjct: 484 EASISWESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIPPCRALCEH-------S 536
Query: 1286 RQQCLFHSMVCDGII--------QCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVC 1337
+++C S++ GI+ C +E++ C E+ + C F+C++G C
Sbjct: 537 KERC--ESVL--GIVGLQWPEDTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQC 592
Query: 1338 ISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRC-ENGHCIPNRWKCDRENDCGD 1396
+ +CDG DC D SDE NC C + C N C+ + CD DC D
Sbjct: 593 VLASRRCDGQADCDDDSDEENC-------GCKERDLWECPSNKQCLKHTVICDGFPDCPD 645
Query: 1397 WSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLL 1456
+ DEK+C S C + C++ CV CDG DC+D SDE C L
Sbjct: 646 YMDEKNC-------------SFCQDDELECANHACVSRDLWCDGEADCSDSSDEWDCVTL 692
Query: 1457 A-NVTAAS 1463
+ NV ++S
Sbjct: 693 SINVNSSS 700
Score = 167 bits (424), Expect = 8e-41
Identities = 128/421 (30%), Positives = 168/421 (39%), Gaps = 67/421 (15%)
Query: 1159 RSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWAC 1218
R + + C+SG+CI C+G NDC DWSDEA+C C + F C G C+ C
Sbjct: 271 RGENFLCASGICIPGKLQCNGYNDCDDWSDEAHCN-----CSENLFHCHTGKCLNYSLVC 325
Query: 1219 DGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHF 1278
DG DC D SDE +C RC +G CI CDG DC D SDE +C H
Sbjct: 326 DGYDDCGDLSDEQNCDCNPTTE-HRCGDGRCIAMEWVCDGDHDCVDKSDEVNCS---CHS 381
Query: 1279 MDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCI 1338
V QC+ + CDG C+DGSDE+ CS C E +C C+
Sbjct: 382 QGLVECRNGQCIPSTFQCDGDEDCKDGSDEE----NCSV---IQTSCQEGDQRCLYNPCL 434
Query: 1339 SLIWKCDGMDDCGDYSDEANCE---------------NPTEAPNCSRYFQFRCENGHCIP 1383
C G C + NC N T PN YF R + I
Sbjct: 435 D---SCGGSSLCDPNNSLNNCSQCEPITLELCMNLPYNSTSYPN---YFGHRTQKEASIS 488
Query: 1384 ------------NRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTC 1431
N +K C + D +P P + C + RC S
Sbjct: 489 WESSLFPALVQTNCYKYLMFFSCTILVPKCDVNTGEHIP---PCRALCEHSKERCESVLG 545
Query: 1432 VMDT-WVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKR 1490
++ W D DC+ +E + N T + C F+C + C+ +R
Sbjct: 546 IVGLQWPED--TDCSQFPEENS----DNQTCLMPDEYVEECSPSHFKCRSGQ-CVLASRR 598
Query: 1491 CDGHQDCQDGRDEANCPTHSTLTCMSRE-FQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
CDG DC D DE NC C R+ ++C + C+ + CDGF DC D DEK C
Sbjct: 599 CDGQADCDDDSDEENCG------CKERDLWECPSNKQCLKHTVICDGFPDCPDYMDEKNC 652
Query: 1550 S 1550
S
Sbjct: 653 S 653
Score = 92.8 bits (229), Expect = 3e-18
Identities = 60/199 (30%), Positives = 86/199 (43%), Gaps = 27/199 (13%)
Query: 1015 NTGSNACVPRPCSLLCLPKANNSRSC------RCPEDVSSSVLPSGDLMCDCPQGYQLKN 1068
NTG + +P PC LC S + PED S P + N
Sbjct: 521 NTGEH--IP-PCRALCEHSKERCESVLGIVGLQWPEDTDCSQFPEENS----------DN 567
Query: 1069 NTCVKEEN---TCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRC 1125
TC+ + C + ++C +G C+ + CD DC D SDE NC DL + C
Sbjct: 568 QTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEENCGCKERDL---WEC 624
Query: 1126 QESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRD 1185
+ C+ + CD DC D DE +C C+ DE C++ C+ CDG+ DC D
Sbjct: 625 PSNKQCLKHTVICDGFPDCPDYMDEKNCSF--CQDDELECANHACVSRDLWCDGEADCSD 682
Query: 1186 WSDEANCTAIYHTCEASNF 1204
SDE +C + +S+F
Sbjct: 683 SSDEWDCVTLSINVNSSSF 701
Score = 87.8 bits (216), Expect = 1e-16
Identities = 65/204 (31%), Positives = 83/204 (40%), Gaps = 31/204 (15%)
Query: 1141 EDDCG----DNSDESHCEM-----HQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEAN 1191
+ DC +NSD C M +C + C SG C+ +S CDG DC D SDE N
Sbjct: 554 DTDCSQFPEENSDNQTCLMPDEYVEECSPSHFKCRSGQCVLASRRCDGQADCDDDSDEEN 613
Query: 1192 CTAIYHTCEASNFQC-RNGHCIPQRWACDGDTDCQDGSDEDPVNCEK-KCNGFRCPNGTC 1249
C E ++C N C+ CDG DC D DE NC + + C N C
Sbjct: 614 CGCK----ERDLWECPSNKQCLKHTVICDGFPDCPDYMDEK--NCSFCQDDELECANHAC 667
Query: 1250 IPSSKHCDGLRDCSDGSDEQHCEPLC--THFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
+ CDG DCSD SDE C L + F+ +R H C DG
Sbjct: 668 VSRDLWCDGEADCSDSSDEWDCVTLSINVNSSSFLMVHRAATEHH--------VCADGWQ 719
Query: 1308 EDAAFAGCSQ----DPEFHKVCDE 1327
E + C Q +P K+ E
Sbjct: 720 EILSQLACKQMGLGEPSVTKLIQE 743
>gi|148727288 low density lipoprotein receptor-related protein 6 [Homo
sapiens]
Length = 1613
Score = 204 bits (520), Expect = 6e-52
Identities = 124/319 (38%), Positives = 171/319 (53%), Gaps = 29/319 (9%)
Query: 760 FILYAVRKSIYRYDLASGATE-QLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLN 818
F+L++ R I R L + +PLTG++ A ALDFD N +YW+D++L I R +N
Sbjct: 633 FLLFSRRADIRRISLETNNNNVAIPLTGVKEASALDFDVTDNRIYWTDISLKTISRAFMN 692
Query: 819 GSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRP 878
GS E ++ GL+ E +A + L + LYW D G +IEV+ DG R +V LD P
Sbjct: 693 GSA-LEHVVEFGLDYPEGMAVDWLGKNLYWADTGTNRIEVSKLDGQHRQVLVWKD-LDSP 750
Query: 879 RALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWT 936
RAL L P EG M+WT+WG KP I R+ MDGS LV +V NG+++D + +YWT
Sbjct: 751 RALALDPAEGFMYWTEWGG-KPKIDRAAMDGSERTTLVP-NVGRANGLTIDYAKRRLYWT 808
Query: 937 DAYLECIERITFSGQQRSVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQMEI 996
D IE G R VI D+LPHP+ + +++ IYW DWS+ SI RA+K SG I
Sbjct: 809 DLDTNLIESSNMLGLNREVIADDLPHPFGLTQYQDYIYWTDWSRRSIERANKTSGQNRTI 868
Query: 997 LANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPEDVSSSVLPSG 1054
+ L +MD+ +F+ + +G N C CS LCL +P G
Sbjct: 869 IQGHLDYVMDILVFHSSRQSGWNECASSNGHCSHLCL------------------AVPVG 910
Query: 1055 DLMCDCPQGYQLK--NNTC 1071
+C CP Y L N TC
Sbjct: 911 GFVCGCPAHYSLNADNRTC 929
Score = 189 bits (481), Expect = 2e-47
Identities = 110/326 (33%), Positives = 177/326 (54%), Gaps = 22/326 (6%)
Query: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQ-LPLTGLRAAVALDFDYEHNCLYWSDLALD 810
C L +LYA R+ + D +G + + GL A A+DF + H +YWSD++ +
Sbjct: 14 CVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEE 73
Query: 811 VIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIV 870
I+R N + + ++ SGL + + LA + L + LYW D+ +IEV+N DG R ++
Sbjct: 74 AIKRTEFNKTESVQNVVVSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLR-KVL 132
Query: 871 NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD- 929
LD+PRA+ L P G M+WTDWG++ P I R+ MDGS+ + +++ ++ WPNG+++D
Sbjct: 133 FWQELDQPRAIALDPSSGFMYWTDWGEV-PKIERAGMDGSSRFIIINSEIYWPNGLTLDY 191
Query: 930 -DQWIYWTDAYLECIERITFSGQQR-SVILDNLPHPYAIAVFKNEIYWDDWSQLSIFRAS 987
+Q +YW DA L I + G R +V+ +LPHP+A+ +F++ +YW DWS SI +
Sbjct: 192 EEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACN 251
Query: 988 KYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVS 1047
KY+G + + + + MD+ F + + + PC + N S C +
Sbjct: 252 KYTGEGLREIHSDIFSPMDIHAFSQQRQPNAT----NPCGI-----DNGGCSHLC---LM 299
Query: 1048 SSVLPSGDLMCDCPQGYQLKNN--TC 1071
S V P C CP G +L N TC
Sbjct: 300 SPVKPF--YQCACPTGVKLLENGKTC 323
Score = 184 bits (466), Expect = 1e-45
Identities = 135/448 (30%), Positives = 221/448 (49%), Gaps = 37/448 (8%)
Query: 760 FILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCL 817
F+L++ + +I R + + LP+ LR A+D+D LYW D ++I++
Sbjct: 935 FLLFSQKSAINRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQE 994
Query: 818 NGSTGQEVIINS----GLETVEA-LAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNS 872
+GS G V+++S LE L+ + S+ +YW I V DG + +V
Sbjct: 995 DGSQGFTVVVSSVPSQNLEIQPYDLSIDIYSRYIYWTCEATNVINVTRLDGR-SVGVVLK 1053
Query: 873 SVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQW 932
DRPRA+V+ P++G M++T+ + P I R+ +DG+ L + P +++D +
Sbjct: 1054 GEQDRPRAVVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRL 1113
Query: 933 --IYWTDAYLECIERITFSGQQRSVILD-NLPHPYAIAVFKNEIYWDDWSQLSIFR---A 986
++W D+ L IE SG R V+ D N+ P + VF+N +YW D Q I +
Sbjct: 1114 GKLFWADSDLRRIESSDLSGANRIVLEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMT 1173
Query: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVP--RPCSLLCLPKANNSRSCRCPE 1044
+ ++++ QL+ + +K + + C CS +CL K + + C CP
Sbjct: 1174 GREGRTKVQARIAQLSDIHAVKEL-NLQEYRQHPCAQDNGGCSHICLVKGDGTTRCSCPM 1232
Query: 1045 DVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCG 1104
+ VL +L C P TC ++ TC + +CI W CD +C
Sbjct: 1233 HL---VLLQDELSCGEPP-------TCSPQQFTCFTGEI-----DCIPVAWRCDGFTECE 1277
Query: 1105 DMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYN 1164
D SDE NCP +C ++QF+C SG CI + +C+ + +C D SDE +CE+ C D++
Sbjct: 1278 DHSDELNCP--VCS-ESQFQC-ASGQCIDGALRCNGDANCQDKSDEKNCEV-LCLIDQFR 1332
Query: 1165 CSSGMCIRSSWVCDGDNDCRDWSDEANC 1192
C++G CI CD + DC D SDE +C
Sbjct: 1333 CANGQCIGKHKKCDHNVDCSDKSDELDC 1360
Score = 166 bits (420), Expect = 2e-40
Identities = 103/312 (33%), Positives = 168/312 (53%), Gaps = 18/312 (5%)
Query: 759 EFILYAVRKSIYRYDLASGATEQ--LPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLC 816
E +L A R + R L + L L +R A+A+D+D +YW+D + I+R
Sbjct: 329 ELLLLARRTDLRRISLDTPDFTDIVLQLEDIRHAIAIDYDPVEGYIYWTDDEVRAIRRSF 388
Query: 817 LNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLD 876
++GS G + ++ + + + +A + +++ LYW D G +IEV +G R +++ L+
Sbjct: 389 IDGS-GSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISED-LE 446
Query: 877 RPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISV--DDQWIY 934
PRA+VL P G M+WTDWG++ P I R+ +DGS LV+ + WPNG+++ D+ IY
Sbjct: 447 EPRAIVLDPMVGYMYWTDWGEI-PKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIY 505
Query: 935 WTDAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDWSQLSIFRASKYSGSQ 993
W DA + IE + G R V++ D +PH + + + +YW DW + SI R K S ++
Sbjct: 506 WGDAKTDKIEVMNTDGTGRRVLVEDKIPHIFGFTLLGDYVYWTDWQRRSIERVHKRS-AE 564
Query: 994 MEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCP------ED 1045
E++ +QL LM +K + GSN C CS LCL + R C CP D
Sbjct: 565 REVIIDQLPDLMGLKATNVHRVIGSNPCAEENGGCSHLCLYRPQGLR-CACPIGFELISD 623
Query: 1046 VSSSVLPSGDLM 1057
+ + ++P L+
Sbjct: 624 MKTCIVPEAFLL 635
Score = 135 bits (341), Expect = 3e-31
Identities = 136/486 (27%), Positives = 197/486 (40%), Gaps = 91/486 (18%)
Query: 812 IQRLCLNGSTGQEVIIN-SGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIV 870
I R+ ++ ++I+ L V A+ ++PL + LYW+D+ I A DG T+V
Sbjct: 944 INRMVIDEQQSPDIILPIHSLRNVRAIDYDPLDKQLYWIDSRQNMIRKAQEDGSQGFTVV 1003
Query: 871 NSSVLDR-----PRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNG 925
SSV + P L + ++WT + I + +DG + ++ + P
Sbjct: 1004 VSSVPSQNLEIQPYDLSIDIYSRYIYWTC--EATNVINVTRLDGRSVGVVLKGEQDRPRA 1061
Query: 926 ISVDDQ--WIYWTDAYLEC--IERITFSGQQRSVIL-DNLPHPYAIAVFKN--EIYWDDW 978
+ V+ + ++Y+T+ IER G +R V+ L P A+A+ +++W D
Sbjct: 1062 VVVNPEKGYMYFTNLQERSPKIERAALDGTEREVLFFSGLSKPIALALDSRLGKLFWAD- 1120
Query: 979 SQLSIFRASKYSGSQMEILANQLTGLMDMKIFYK-GKNTGSNACVPRPCSLLCLPKAN-N 1036
S L +S SG AN++ L D I G N + K +
Sbjct: 1121 SDLRRIESSDLSG------ANRIV-LEDSNILQPVGLTVFENWLYWIDKQQQMIEKIDMT 1173
Query: 1037 SRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRCS--NGNCINSI 1094
R R + QL + VKE N Q+ C+ NG C
Sbjct: 1174 GREGRTKVQARIA---------------QLSDIHAVKELNLQEYRQHPCAQDNGGC---- 1214
Query: 1095 WWCDFDNDC---GDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDES 1151
+ C GD + +CP + L + C E TC P
Sbjct: 1215 -----SHICLVKGDGTTRCSCPMHLVLLQDELSCGEPPTCSP------------------ 1251
Query: 1152 HCEMHQCRSDEYNCSSGM--CIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNG 1209
++ C +G CI +W CDG +C D SDE NC C S FQC +G
Sbjct: 1252 ---------QQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV----CSESQFQCASG 1298
Query: 1210 HCIPQRWACDGDTDCQDGSDEDPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSD 1267
CI C+GD +CQD SDE NCE C + FRC NG CI K CD DCSD SD
Sbjct: 1299 QCIDGALRCNGDANCQDKSDEK--NCEVLCLIDQFRCANGQCIGKHKKCDHNVDCSDKSD 1356
Query: 1268 EQHCEP 1273
E C P
Sbjct: 1357 ELDCYP 1362
Score = 95.5 bits (236), Expect = 5e-19
Identities = 53/153 (34%), Positives = 75/153 (49%), Gaps = 33/153 (21%)
Query: 1399 DEKDCGDSHILPFSTPGPSTCLPNYYRCSSGT--CVMDTWVCDGYRDCADGSDEEACPLL 1456
DE CG+ P TC P + C +G C+ W CDG+ +C D SDE CP+
Sbjct: 1239 DELSCGE----------PPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDELNCPV- 1287
Query: 1457 ANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMS 1516
C +F+C + CI RC+G +CQD DE NC + C+
Sbjct: 1288 --------------CSESQFQCASGQ-CIDGALRCNGDANCQDKSDEKNCE----VLCLI 1328
Query: 1517 REFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
+F+C +G+ CI ++CD +DCSD+SDE C
Sbjct: 1329 DQFRCANGQ-CIGKHKKCDHNVDCSDKSDELDC 1360
Score = 91.7 bits (226), Expect = 7e-18
Identities = 59/162 (36%), Positives = 74/162 (45%), Gaps = 18/162 (11%)
Query: 1156 HQCRSDEYNCSSGMCIRSSWVCDGDNDCRD------WSDEANCTAIYHTCEASNFQCRNG 1209
H C D CS ++ DG C DE +C TC F C G
Sbjct: 1205 HPCAQDNGGCSHICLVKG----DGTTRCSCPMHLVLLQDELSCGEP-PTCSPQQFTCFTG 1259
Query: 1210 H--CIPQRWACDGDTDCQDGSDEDPVNCEKKCNG-FRCPNGTCIPSSKHCDGLRDCSDGS 1266
CIP W CDG T+C+D SDE +NC F+C +G CI + C+G +C D S
Sbjct: 1260 EIDCIPVAWRCDGFTECEDHSDE--LNCPVCSESQFQCASGQCIDGALRCNGDANCQDKS 1317
Query: 1267 DEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE 1308
DE++CE LC F C N QC+ CD + C D SDE
Sbjct: 1318 DEKNCEVLCL-IDQFRCAN-GQCIGKHKKCDHNVDCSDKSDE 1357
Score = 87.4 bits (215), Expect = 1e-16
Identities = 58/152 (38%), Positives = 66/152 (43%), Gaps = 24/152 (15%)
Query: 1267 DEQHC-EPLCTHFMDFVCKNRQ-QCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKV 1324
DE C EP F C + C+ + CDG +C D SDE C V
Sbjct: 1239 DELSCGEPPTCSPQQFTCFTGEIDCIPVAWRCDGFTECEDHSDE----LNCP-------V 1287
Query: 1325 CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPN 1384
C E FQC +G CI +C+G +C D SDE NCE QFRC NG CI
Sbjct: 1288 CSESQFQCASGQCIDGALRCNGDANCQDKSDEKNCEV------LCLIDQFRCANGQCIGK 1341
Query: 1385 RWKCDRENDCGDWSDEKDCGDSHILPFSTPGP 1416
KCD DC D SDE DC P P P
Sbjct: 1342 HKKCDHNVDCSDKSDELDC-----YPTEEPAP 1368
Score = 82.8 bits (203), Expect = 3e-15
Identities = 58/182 (31%), Positives = 78/182 (42%), Gaps = 41/182 (22%)
Query: 1334 NGVCISL-IWKCDGMDDCGD------YSDEANCENPTEAPNCSRYFQFRCENGH--CIPN 1384
NG C + + K DG C DE +C P P CS QF C G CIP
Sbjct: 1211 NGGCSHICLVKGDGTTRCSCPMHLVLLQDELSCGEP---PTCSPQ-QFTCFTGEIDCIPV 1266
Query: 1385 RWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDC 1444
W+CD +C D SDE +C C + ++C+SG C+ C+G +C
Sbjct: 1267 AWRCDGFTECEDHSDELNC-------------PVCSESQFQCASGQCIDGALRCNGDANC 1313
Query: 1445 ADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEA 1504
D SDE+ C +L C +F C + CI K+CD + DC D DE
Sbjct: 1314 QDKSDEKNCEVL--------------CLIDQFRCANGQ-CIGKHKKCDHNVDCSDKSDEL 1358
Query: 1505 NC 1506
+C
Sbjct: 1359 DC 1360
Score = 68.9 bits (167), Expect = 5e-11
Identities = 41/110 (37%), Positives = 55/110 (50%), Gaps = 16/110 (14%)
Query: 1446 DGSDEEACP-----LLANVTAASTPTQLGRCDRFEFECHQPKT-CIPNWKRCDGHQDCQD 1499
DG+ +CP L ++ PT C +F C + CIP RCDG +C+D
Sbjct: 1223 DGTTRCSCPMHLVLLQDELSCGEPPT----CSPQQFTCFTGEIDCIPVAWRCDGFTECED 1278
Query: 1500 GRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
DE NCP C +FQC G+ CI + RC+G +C D+SDEK C
Sbjct: 1279 HSDELNCP-----VCSESQFQCASGQ-CIDGALRCNGDANCQDKSDEKNC 1322
>gi|119709832 low density lipoprotein receptor-related protein 5 [Homo
sapiens]
Length = 1615
Score = 198 bits (503), Expect = 6e-50
Identities = 117/313 (37%), Positives = 174/313 (55%), Gaps = 12/313 (3%)
Query: 735 TCSGGDVEARLEGELVPCPLAEENEFILYAVRKSIYRYDLASGATE-QLPLTGLRAAVAL 793
T G + L ++ C + E F+++ R +I+R L + + +PLTG++ A AL
Sbjct: 623 TRCGCPIGLELLSDMKTCIVPEA--FLVFTSRAAIHRISLETNNNDVAIPLTGVKEASAL 680
Query: 794 DFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGF 853
DFD +N +YW+D++L I R +NGS+ + V+ GL+ E +A + + + LYW D G
Sbjct: 681 DFDVSNNHIYWTDVSLKTISRAFMNGSSVEHVV-EFGLDYPEGMAVDWMGKNLYWADTGT 739
Query: 854 KKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAY 913
+IEVA DG FR +V LD PR+L L P +G ++WT+WG KP I R+ MDG+
Sbjct: 740 NRIEVARLDGQFRQVLVWRD-LDNPRSLALDPTKGYIYWTEWGG-KPRIVRAFMDGTNCM 797
Query: 914 HLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAVFKN 971
LV + V N +++D DQ +YWTD IE GQ+R VI D+LPHP+ + + +
Sbjct: 798 TLVDK-VGRANDLTIDYADQRLYWTDLDTNMIESSNMLGQERVVIADDLPHPFGLTQYSD 856
Query: 972 EIYWDDWSQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLL 1029
IYW DW+ SI RA K SG ++ L +MD+ +F+ + G N C+ C L
Sbjct: 857 YIYWTDWNLHSIERADKTSGRNRTLIQGHLDFVMDILVFHSSRQDGLNDCMHNNGQCGQL 916
Query: 1030 CLPKANNSRSCRC 1042
CL R C C
Sbjct: 917 CLAIPGGHR-CGC 928
Score = 169 bits (427), Expect = 4e-41
Identities = 110/336 (32%), Positives = 174/336 (51%), Gaps = 34/336 (10%)
Query: 749 LVPCPL-AEENEFILYAVRKSIYRYDLASGATEQ-LPLTGLRAAVALDFDYEHNCLYWSD 806
L CP A + +L+A R+ + D E + ++GL A A+DF + +YW+D
Sbjct: 22 LCGCPAPAAASPLLLFANRRDVRLVDAGGVKLESTIVVSGLEDAAAVDFQFSKGAVYWTD 81
Query: 807 LALDVIQRLCLN--GSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGD 864
++ + I++ LN G+ Q V+I SGL + + LA + + + LYW D+ +IEVAN +G
Sbjct: 82 VSEEAIKQTYLNQTGAAVQNVVI-SGLVSPDGLACDWVGKKLYWTDSETNRIEVANLNGT 140
Query: 865 FRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPN 924
R + LD+PRA+ L P G M+WTDWG+ P I R+ MDGS +V D+ WPN
Sbjct: 141 SRKVLFWQD-LDQPRAIALDPAHGYMYWTDWGET-PRIERAGMDGSTRKIIVDSDIYWPN 198
Query: 925 GISVD--DQWIYWTDAYLECIERITFSGQQRSVILD-NLPHPYAIAVFKNEIYWDDWSQL 981
G+++D +Q +YW DA L I R G R +++ +L HP+A+ + + +YW DW
Sbjct: 199 GLTIDLEEQKLYWADAKLSFIHRANLDGSFRQKVVEGSLTHPFALTLSGDTLYWTDWQTR 258
Query: 982 SIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPRP---CSLLCLPKANNSR 1038
SI +K +G + + + + L MD+++ + + + CS LCL
Sbjct: 259 SIHACNKRTGGKRKEILSALYSPMDIQVLSQERQPFFHTRCEEDNGGCSHLCL------- 311
Query: 1039 SCRCPEDVSSSVLPSGDLM-CDCPQGYQLKNN--TC 1071
+ PS C CP G QL++N TC
Sbjct: 312 -----------LSPSEPFYTCACPTGVQLQDNGRTC 336
Score = 167 bits (423), Expect = 1e-40
Identities = 107/316 (33%), Positives = 168/316 (53%), Gaps = 18/316 (5%)
Query: 755 AEENEFILYAVRKSIYRYDLASGATEQLPLT--GLRAAVALDFDYEHNCLYWSDLALDVI 812
A E +L A R + R L + + L +R A+A+D+D +YW+D + I
Sbjct: 338 AGAEEVLLLARRTDLRRISLDTPDFTDIVLQVDDIRHAIAIDYDPLEGYVYWTDDEVRAI 397
Query: 813 QRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNS 872
+R L+GS G + ++N+ + + +A + +++ LYW D G +IEV +G R +V+
Sbjct: 398 RRAYLDGS-GAQTLVNTEINDPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTSRKILVSE 456
Query: 873 SVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQ- 931
LD PRA+ L P G+M+WTDWG+ P I +N+DG LV+ + WPNG+++D Q
Sbjct: 457 D-LDEPRAIALHPVMGLMYWTDWGE-NPKIECANLDGQERRVLVNASLGWPNGLALDLQE 514
Query: 932 -WIYWTDAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDWSQLSIFRASKY 989
+YW DA + IE I G +R +L D LPH + + + IYW DW + SI R K
Sbjct: 515 GKLYWGDAKTDKIEVINVDGTKRRTLLEDKLPHIFGFTLLGDFIYWTDWQRRSIERVHKV 574
Query: 990 SGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCP---- 1043
S+ +++ +QL LM +K K G+N C R CS LC + +R C CP
Sbjct: 575 KASR-DVIIDQLPDLMGLKAVNVAKVVGTNPCADRNGGCSHLCFFTPHATR-CGCPIGLE 632
Query: 1044 --EDVSSSVLPSGDLM 1057
D+ + ++P L+
Sbjct: 633 LLSDMKTCIVPEAFLV 648
Score = 132 bits (332), Expect = 4e-30
Identities = 116/444 (26%), Positives = 188/444 (42%), Gaps = 52/444 (11%)
Query: 760 FILYAVRKSIYRY--DLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCL 817
F+L++ + +I R D LPL GLR A+D+D +YW +D Q +
Sbjct: 947 FLLFSQKSAISRMIPDDQHSPDLILPLHGLRNVKAIDYDPLDKFIYW----VDGRQNIKR 1002
Query: 818 NGSTGQEVIINSGLETVEA-------LAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIV 870
G + + + L + L+ + S+ L+W I V G+ + +V
Sbjct: 1003 AKDDGTQPFVLTSLSQGQNPDRQPHDLSIDIYSRTLFWTCEATNTINVHRLSGE-AMGVV 1061
Query: 871 NSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDD 930
D+PRA+V+ + G +++T+ D I R+ +DG+ L + + P + VD+
Sbjct: 1062 LRGDRDKPRAIVVNAERGYLYFTNMQDRAAKIERAALDGTEREVLFTTGLIRPVALVVDN 1121
Query: 931 QW--IYWTDAYLECIERITFSGQQRSVILD-NLPHPYAIAVFKNEIYWDDWSQLSIFRAS 987
++W DA L+ IE SG R + D N+ P + + +YW D Q I R
Sbjct: 1122 TLGKLFWVDADLKRIESCDLSGANRLTLEDANIVQPLGLTILGKHLYWIDRQQQMIERVE 1181
Query: 988 KYSGSQMEILANQLTGLMDMKIFYKG--KNTGSNACVPRP--CSLLCLPKANNSRSCRCP 1043
K +G + + ++ L + + + ++ C CS +C+ K + + C CP
Sbjct: 1182 KTTGDKRTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSHICIAKGDGTPRCSCP 1241
Query: 1044 EDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYRC------------------ 1085
+ VL L C P C E C+ +RC
Sbjct: 1242 VHL---VLLQNLLTCGEPPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVC 1298
Query: 1086 -------SNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKC 1138
+ G C++ CD + DC D SDE +C IC L QFRC SG C+ + +C
Sbjct: 1299 SAAQFPCARGQCVDLRLRCDGEADCQDRSDEADC-DAIC-LPNQFRC-ASGQCVLIKQQC 1355
Query: 1139 DLEDDCGDNSDESHCEMHQCRSDE 1162
D DC D SDE CE+ + SD+
Sbjct: 1356 DSFPDCIDGSDELMCEITKPPSDD 1379
Score = 127 bits (320), Expect = 9e-29
Identities = 130/468 (27%), Positives = 191/468 (40%), Gaps = 96/468 (20%)
Query: 830 GLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGD--FRLTIVNSSVLD--RPRALVLVP 885
GL V+A+ ++PL + +YWVD G + I+ A DG F LT ++ +P L +
Sbjct: 975 GLRNVKAIDYDPLDKFIYWVD-GRQNIKRAKDDGTQPFVLTSLSQGQNPDRQPHDLSIDI 1033
Query: 886 QEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVDDQ--WIYWTDAYLEC- 942
+FWT ++R + G A ++ D P I V+ + ++Y+T+
Sbjct: 1034 YSRTLFWTCEATNTINVHR--LSGEAMGVVLRGDRDKPRAIVVNAERGYLYFTNMQDRAA 1091
Query: 943 -IERITFSGQQRSVILDN-LPHPYAIAVFKN--EIYWDDWSQLSIFRASKYSGSQMEILA 998
IER G +R V+ L P A+ V +++W D + L + SG A
Sbjct: 1092 KIERAALDGTEREVLFTTGLIRPVALVVDNTLGKLFWVD-ADLKRIESCDLSG------A 1144
Query: 999 NQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANN--SRSCRCPEDVSSSVLPSGDL 1056
N+LT +A + +P L L K R + E V + +GD
Sbjct: 1145 NRLTL--------------EDANIVQPLGLTILGKHLYWIDRQQQMIERVEKT---TGDK 1187
Query: 1057 MCDCP------QGYQLKNNTCVKE--ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSD 1108
G ++E + C R+ CS+ CI GD +
Sbjct: 1188 RTRIQGRVAHLTGIHAVEEVSLEEFSAHPCARDNGGCSH-ICIAK----------GDGTP 1236
Query: 1109 ERNCPTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSG 1168
+CP + L C E TC P D++ C++G
Sbjct: 1237 RCSCPVHLVLLQNLLTCGEPPTCSP---------------------------DQFACATG 1269
Query: 1169 M--CIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQD 1226
CI +W CDG +C D SDE C C A+ F C G C+ R CDG+ DCQD
Sbjct: 1270 EIDCIPGAWRCDGFPECDDQSDEEGCPV----CSAAQFPCARGQCVDLRLRCDGEADCQD 1325
Query: 1227 GSDEDPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCE 1272
SDE +C+ C N FRC +G C+ + CD DC DGSDE CE
Sbjct: 1326 RSDE--ADCDAICLPNQFRCASGQCVLIKQQCDSFPDCIDGSDELMCE 1371
Score = 107 bits (267), Expect = 1e-22
Identities = 58/143 (40%), Positives = 69/143 (48%), Gaps = 25/143 (17%)
Query: 1315 CSQDPEFHKVCDEFGFQCQNGV--CISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYF 1372
C + P C F C G CI W+CDG +C D SDE C P CS
Sbjct: 1253 CGEPP----TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC------PVCSAA- 1301
Query: 1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCV 1432
QF C G C+ R +CD E DC D SDE DC + CLPN +RC+SG CV
Sbjct: 1302 QFPCARGQCVDLRLRCDGEADCQDRSDEADCD------------AICLPNQFRCASGQCV 1349
Query: 1433 MDTWVCDGYRDCADGSDEEACPL 1455
+ CD + DC DGSDE C +
Sbjct: 1350 LIKQQCDSFPDCIDGSDELMCEI 1372
Score = 103 bits (257), Expect = 2e-21
Identities = 50/136 (36%), Positives = 72/136 (52%), Gaps = 23/136 (16%)
Query: 1416 PSTCLPNYYRCSSGT--CVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDR 1473
P TC P+ + C++G C+ W CDG+ +C D SDEE CP+ C
Sbjct: 1256 PPTCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPV---------------CSA 1300
Query: 1474 FEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSER 1533
+F C + + C+ RCDG DCQD DEA+C C+ +F+C G+ C+++ ++
Sbjct: 1301 AQFPCARGQ-CVDLRLRCDGEADCQDRSDEADCDA----ICLPNQFRCASGQ-CVLIKQQ 1354
Query: 1534 CDGFLDCSDESDEKAC 1549
CD F DC D SDE C
Sbjct: 1355 CDSFPDCIDGSDELMC 1370
Score = 82.8 bits (203), Expect = 3e-15
Identities = 46/115 (40%), Positives = 54/115 (46%), Gaps = 9/115 (7%)
Query: 1198 TCEASNFQCRNGH--CIPQRWACDGDTDCQDGSDED--PVNCEKKCNGFRCPNGTCIPSS 1253
TC F C G CIP W CDG +C D SDE+ PV + F C G C+
Sbjct: 1258 TCSPDQFACATGEIDCIPGAWRCDGFPECDDQSDEEGCPVCSAAQ---FPCARGQCVDLR 1314
Query: 1254 KHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE 1308
CDG DC D SDE C+ +C F C + QC+ CD C DGSDE
Sbjct: 1315 LRCDGEADCQDRSDEADCDAICLP-NQFRCAS-GQCVLIKQQCDSFPDCIDGSDE 1367
Score = 78.6 bits (192), Expect = 6e-14
Identities = 49/132 (37%), Positives = 65/132 (49%), Gaps = 17/132 (12%)
Query: 1231 DPVNCEKKCNGFRCPNGT--CIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQ 1288
+P C + F C G CIP + CDG +C D SDE+ C P+C+ F C R Q
Sbjct: 1255 EPPTCSP--DQFACATGEIDCIPGAWRCDGFPECDDQSDEEGC-PVCSA-AQFPCA-RGQ 1309
Query: 1289 CLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMD 1348
C+ + CDG C+D SDE A C +C F+C +G C+ + +CD
Sbjct: 1310 CVDLRLRCDGEADCQDRSDE----ADCDA------ICLPNQFRCASGQCVLIKQQCDSFP 1359
Query: 1349 DCGDYSDEANCE 1360
DC D SDE CE
Sbjct: 1360 DCIDGSDELMCE 1371
Score = 69.3 bits (168), Expect = 4e-11
Identities = 41/109 (37%), Positives = 51/109 (46%), Gaps = 14/109 (12%)
Query: 1446 DGSDEEACP----LLANVTAASTPTQLGRCDRFEFECHQPKT-CIPNWKRCDGHQDCQDG 1500
DG+ +CP LL N+ P C +F C + CIP RCDG +C D
Sbjct: 1233 DGTPRCSCPVHLVLLQNLLTCGEPPT---CSPDQFACATGEIDCIPGAWRCDGFPECDDQ 1289
Query: 1501 RDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
DE CP C + +F C G+ C+ L RCDG DC D SDE C
Sbjct: 1290 SDEEGCP-----VCSAAQFPCARGQ-CVDLRLRCDGEADCQDRSDEADC 1332
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 187 bits (474), Expect = 1e-46
Identities = 130/408 (31%), Positives = 177/408 (43%), Gaps = 61/408 (14%)
Query: 1058 CDCPQGYQLKNNTCVKEENTCL----RNQYR--------CSNGNCINSIWWCDFDNDCGD 1105
C CP+G L C+ E +C RN + C N C W C D
Sbjct: 1312 CFCPEGTLLHGGACL-EPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQWHCGGDGG--- 1367
Query: 1106 MSDERNCPTTI-CDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYN 1164
+C + + + CQE+G C+P + CD +DDCGD SDE C C +
Sbjct: 1368 -----HCEELVPACAEGEALCQENGHCVPHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMT 1422
Query: 1165 CSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDC 1224
CSSG C+ + +CD +DC D +DE + + C C +G C+P CDG DC
Sbjct: 1423 CSSGHCLPLALLCDRQDDCGDGTDEPS-----YPCPQGLLACADGRCLPPALLCDGHPDC 1477
Query: 1225 QDGSDEDPVNCEKKC--NGFRCPNGTCIPSSKHCDGLRDCSDGSDE--QHCEPLCTHFMD 1280
D +DE+ + C C +GTC+ + + CDG+ DC DG+DE HC PL +
Sbjct: 1478 LDAADEESCLGQVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHC-PLPS---- 1532
Query: 1281 FVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISL 1340
+ + GS + A+ S P C F F+C +G C
Sbjct: 1533 ----------LPTPPASTLPGPSPGSLDTASSPLASASPA--PPCGPFEFRCGSGECTPR 1580
Query: 1341 IWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
W+CD +DC D SDE C P C+ + HC+ CD C D SDE
Sbjct: 1581 GWRCDQEEDCADGSDERGCGGP-----CAPHHAPCARGPHCVSPEQLCDGVRQCPDGSDE 1635
Query: 1401 --KDCGDSHILPFSTPGPS-TCLP-NYYRCSSGTCVMDTWVCDGYRDC 1444
CG LP + GP+ T LP Y C +GTC+ VCDG DC
Sbjct: 1636 GPDACGG---LP-ALGGPNRTGLPCPEYTCPNGTCIGFQLVCDGQPDC 1679
Score = 175 bits (443), Expect = 5e-43
Identities = 119/370 (32%), Positives = 157/370 (42%), Gaps = 75/370 (20%)
Query: 1164 NCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCR-NGHCIPQRWACDGDT 1222
+C + C W C GD +C + C C+ NGHC+P W CD
Sbjct: 1349 DCGNCTCQEGQWHCGGDG--------GHCEELVPACAEGEALCQENGHCVPHGWLCDNQD 1400
Query: 1223 DCQDGSDEDPVNCEKKCNG-FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDF 1281
DC DGSDE+ G C +G C+P + CD DC DG+DE C +
Sbjct: 1401 DCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSYP--CPQGLLA 1458
Query: 1282 VCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLI 1341
R CL +++CDG C D +DE++ + C C +G C+ I
Sbjct: 1459 CADGR--CLPPALLCDGHPDCLDAADEESCLGQVT--------CVPGEVSCVDGTCLGAI 1508
Query: 1342 WKCDGMDDCGDYSDEA--NCENPT----------------------------EAPNCSRY 1371
CDG+ DC D +DE +C P+ AP C
Sbjct: 1509 QLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLASASPAPPCGP- 1567
Query: 1372 FQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGT- 1430
F+FRC +G C P W+CD+E DC D SDE+ CG GP C P++ C+ G
Sbjct: 1568 FEFRCGSGECTPRGWRCDQEEDCADGSDERGCG----------GP--CAPHHAPCARGPH 1615
Query: 1431 CVMDTWVCDGYRDCADGSDE--EACPLLANVTAASTPTQLG-RCDRFEFECHQPKTCIPN 1487
CV +CDG R C DGSDE +AC + A P + G C E+ C TCI
Sbjct: 1616 CVSPEQLCDGVRQCPDGSDEGPDAC---GGLPALGGPNRTGLPCP--EYTCPN-GTCIGF 1669
Query: 1488 WKRCDGHQDC 1497
CDG DC
Sbjct: 1670 QLVCDGQPDC 1679
Score = 149 bits (375), Expect = 4e-35
Identities = 134/452 (29%), Positives = 170/452 (37%), Gaps = 120/452 (26%)
Query: 1170 CIRSSWVCDGDNDCRDWSDEANCTAI---------------YHTCEASNFQCRNGHCIPQ 1214
C+ + CD DC E C+AI + + E + QC G Q
Sbjct: 1229 CLYDACGCDSGGDC-----ECLCSAIATYADECARHGHHVRWRSQELCSLQCEGG----Q 1279
Query: 1215 RWACDGDT---DCQDGSDEDPVNCEKKC--NGFRCPNGTCI-------PSSKHCD-GLRD 1261
+ G T C + E +C+ G CP GT + P+S C+ G
Sbjct: 1280 VYEACGPTCPPTCHEQHPEPGWHCQVVACVEGCFCPEGTLLHGGACLEPASCPCEWGRNS 1339
Query: 1262 CSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEF 1321
GS Q CT C+ Q +H C G DG + C+ E
Sbjct: 1340 FPPGSVLQKDCGNCT------CQEGQ---WH---CGG-----DGGHCEELVPACA---EG 1379
Query: 1322 HKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHC 1381
+C E NG C+ W CD DDCGD SDE C AP C Q C +GHC
Sbjct: 1380 EALCQE------NGHCVPHGWLCDNQDDCGDGSDEEGCA----APGCGEG-QMTCSSGHC 1428
Query: 1382 IPNRWKCDRENDCGDWSDEKD---------CGDSHILP-----------------FSTPG 1415
+P CDR++DCGD +DE C D LP S G
Sbjct: 1429 LPLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLG 1488
Query: 1416 PSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEA--CPLLA---------------N 1458
TC+P C GTC+ +CDG DC DG+DE CPL + +
Sbjct: 1489 QVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGS 1548
Query: 1459 VTAASTPTQLGR----CDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTC 1514
+ AS+P C FEF C + C P RCD +DC DG DE C C
Sbjct: 1549 LDTASSPLASASPAPPCGPFEFRCGSGE-CTPRGWRCDQEEDCADGSDERGCGG----PC 1603
Query: 1515 MSREFQCEDGEACIVLSERCDGFLDCSDESDE 1546
C G C+ + CDG C D SDE
Sbjct: 1604 APHHAPCARGPHCVSPEQLCDGVRQCPDGSDE 1635
Score = 144 bits (362), Expect = 1e-33
Identities = 122/439 (27%), Positives = 158/439 (35%), Gaps = 124/439 (28%)
Query: 1129 GTCI-PLSYKCD-----------LEDDCGD----------NSDESHCE--MHQCRSDEYN 1164
G C+ P S C+ L+ DCG+ D HCE + C E
Sbjct: 1323 GACLEPASCPCEWGRNSFPPGSVLQKDCGNCTCQEGQWHCGGDGGHCEELVPACAEGEAL 1382
Query: 1165 CS-SGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTD 1223
C +G C+ W+CD +DC D SDE C A C C +GHC+P CD D
Sbjct: 1383 CQENGHCVPHGWLCDNQDDCGDGSDEEGCAA--PGCGEGQMTCSSGHCLPLALLCDRQDD 1440
Query: 1224 CQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVC 1283
C DG+DE C + C +G C+P + CDG DC D +DE+ C T V
Sbjct: 1441 CGDGTDEPSYPCPQGL--LACADGRCLPPALLCDGHPDCLDAADEESCLGQVTCVPGEVS 1498
Query: 1284 KNRQQCLFHSMVCDGIIQCRDGSDE-----------------------------DAAFAG 1314
CL +CDG+ C DG+DE + A
Sbjct: 1499 CVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGSLDTASSPLAS 1558
Query: 1315 CSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENP--------TEAP 1366
S P C F F+C +G C W+CD +DC D SDE C P P
Sbjct: 1559 ASPAPP----CGPFEFRCGSGECTPRGWRCDQEEDCADGSDERGCGGPCAPHHAPCARGP 1614
Query: 1367 NCSRYFQ-------------------------------------FRCENGHCIPNRWKCD 1389
+C Q + C NG CI + CD
Sbjct: 1615 HCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGLPCPEYTCPNGTCIGFQLVCD 1674
Query: 1390 RENDC------GDWSDEKDCGDSHILPFSTPGP--STCLP----NYYRCSS-GTCVMDTW 1436
+ DC G +E+ CG P+S GP TC P RCS G V+
Sbjct: 1675 GQPDCGRPGQVGPSPEEQGCGAWG--PWSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQN- 1731
Query: 1437 VCDGYRDCADGSDEEACPL 1455
C G + ACP+
Sbjct: 1732 -CPGPEHQSQACFTAACPV 1749
Score = 82.8 bits (203), Expect = 3e-15
Identities = 79/284 (27%), Positives = 105/284 (36%), Gaps = 66/284 (23%)
Query: 1025 PCSLLC-----LPKANNSRSCRCPEDVSSSV----LPSGDLMCDC-PQGYQLKNNTCVKE 1074
P +LLC + S CP+ + + LP L+CD P +
Sbjct: 1430 PLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRCLPPA-LLCDGHPDCLDAADEESCLG 1488
Query: 1075 ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDER--NCPTTIC--------------D 1118
+ TC+ + C +G C+ +I CD DC D +DE +CP
Sbjct: 1489 QVTCVPGEVSCVDGTCLGAIQLCDGVWDCPDGADEGPGHCPLPSLPTPPASTLPGPSPGS 1548
Query: 1119 LDT-----------------QFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSD 1161
LDT +FRC SG C P ++CD E+DC D SDE C C
Sbjct: 1549 LDTASSPLASASPAPPCGPFEFRCG-SGECTPRGWRCDQEEDCADGSDERGCG-GPCAPH 1606
Query: 1162 EYNCSSGM-CIRSSWVCDGDNDCRDWSDEA-------------NCTAIYHTCEASNFQCR 1207
C+ G C+ +CDG C D SDE N T + + C
Sbjct: 1607 HAPCARGPHCVSPEQLCDGVRQCPDGSDEGPDACGGLPALGGPNRTGL----PCPEYTCP 1662
Query: 1208 NGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCN--GFRCPNGTC 1249
NG CI + CDG DC P E+ C G P G C
Sbjct: 1663 NGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCGAWGPWSPWGPC 1706
Score = 65.5 bits (158), Expect = 6e-10
Identities = 68/261 (26%), Positives = 89/261 (34%), Gaps = 49/261 (18%)
Query: 1288 QCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPE----FHKVCDEFGFQ-CQNGVCISLIW 1342
+C+ CDG++ C DGSDE+ GC PE FH Q G + W
Sbjct: 2245 ECVLRGGPCDGVLDCEDGSDEE----GCVLLPEGTGRFHSTAKTLALSSAQPGQLLH--W 2298
Query: 1343 KCDGMDDC-----GDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRE-NDCGD 1396
+G+ + G S + E +P + E+ + E
Sbjct: 2299 PREGLAETEHWPPGQESPTSPTETRPVSPGPASGVPHHGESVQMVTTTPIPQMEARTLPP 2358
Query: 1397 WSDEKDCGDSHILPFSTPG----------PSTCLPNYYRCSSGTCVMDTWVCDGYRDCAD 1446
H + +TP P C P C CV VCDG DC D
Sbjct: 2359 GMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQTPCEVLGCVEQAQVCDGREDCLD 2418
Query: 1447 GSDEEAC--------PLLANVTAAST-------------PTQLGRCDRFEFECHQPKTCI 1485
GSDE C P L + AAST P C + C + C+
Sbjct: 2419 GSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLPASRALCSPSQLSCGSGE-CL 2477
Query: 1486 PNWKRCDGHQDCQDGRDEANC 1506
+RCD DCQDG DE C
Sbjct: 2478 SAERRCDLRPDCQDGSDEDGC 2498
Score = 57.8 bits (138), Expect = 1e-07
Identities = 68/283 (24%), Positives = 93/283 (32%), Gaps = 50/283 (17%)
Query: 1314 GCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQ 1373
GC +C G +C +G C+ CDG+ DC D SDE C E
Sbjct: 2223 GCEPGSPPAPLCPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLLPEGTGRFHSTA 2282
Query: 1374 FRCENGHCIPNR---WKCDRENDCGDW--SDEKDCGDSHILPFSTPGPSTCLPNYYRCSS 1428
P + W + + W E + P S PGP++ +P++ S
Sbjct: 2283 KTLALSSAQPGQLLHWPREGLAETEHWPPGQESPTSPTETRPVS-PGPASGVPHH--GES 2339
Query: 1429 GTCVMDTWVCD--------GYRDCADGSDEEACPLL-ANVTAASTPTQLGRCDRFEFECH 1479
V T + G P A + A P +C + C
Sbjct: 2340 VQMVTTTPIPQMEARTLPPGMAAVTVVPPHPVTPATPAGQSVAPGPFPPVQCGPGQTPC- 2398
Query: 1480 QPKTCIPNWKRCDGHQDCQDGRDEANC------------------------PT------- 1508
+ C+ + CDG +DC DG DE +C PT
Sbjct: 2399 EVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGLP 2458
Query: 1509 HSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSD 1551
S C + C GE C+ RCD DC D SDE C D
Sbjct: 2459 ASRALCSPSQLSCGSGE-CLSAERRCDLRPDCQDGSDEDGCVD 2500
Score = 54.3 bits (129), Expect = 1e-06
Identities = 32/107 (29%), Positives = 38/107 (35%), Gaps = 32/107 (29%)
Query: 1157 QCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCT----------------------- 1193
QC + C C+ + VCDG DC D SDE +C
Sbjct: 2390 QCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMM 2449
Query: 1194 ---------AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDED 1231
A C S C +G C+ CD DCQDGSDED
Sbjct: 2450 PTMALPGLPASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDED 2496
Score = 53.5 bits (127), Expect = 2e-06
Identities = 42/161 (26%), Positives = 55/161 (34%), Gaps = 51/161 (31%)
Query: 1426 CSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCI 1485
C + TC W C G G EE P C E C + C+
Sbjct: 1350 CGNCTCQEGQWHCGG----DGGHCEELVPA---------------CAEGEALCQENGHCV 1390
Query: 1486 PNWKRCDGHQDCQDGRDEANCPT----HSTLTCMS-----------REFQCEDGE----- 1525
P+ CD DC DG DE C +TC S R+ C DG
Sbjct: 1391 PHGWLCDNQDDCGDGSDEEGCAAPGCGEGQMTCSSGHCLPLALLCDRQDDCGDGTDEPSY 1450
Query: 1526 ------------ACIVLSERCDGFLDCSDESDEKACSDELT 1554
C+ + CDG DC D +DE++C ++T
Sbjct: 1451 PCPQGLLACADGRCLPPALLCDGHPDCLDAADEESCLGQVT 1491
Score = 52.0 bits (123), Expect = 6e-06
Identities = 35/131 (26%), Positives = 52/131 (39%), Gaps = 28/131 (21%)
Query: 1249 CIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFV----CKNRQQCLFHSMVCDGIIQCRD 1304
C+ ++ CDG DC DGSDE+HC ++ + + + +M G+
Sbjct: 2403 CVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGL----- 2457
Query: 1305 GSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTE 1364
P +C C +G C+S +CD DC D SDE C +
Sbjct: 2458 --------------PASRALCSPSQLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVL 2503
Query: 1365 AP-----NCSR 1370
AP +CSR
Sbjct: 2504 APWSVWSSCSR 2514
Score = 48.9 bits (115), Expect = 5e-05
Identities = 78/333 (23%), Positives = 103/333 (30%), Gaps = 84/333 (25%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC------------------------P 1113
C Q C C+ CD DC D SDER+C P
Sbjct: 2391 CGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMP 2450
Query: 1114 T----------TICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHC------EMHQ 1157
T +C +Q C SG C+ +CDL DC D SDE C
Sbjct: 2451 TMALPGLPASRALCS-PSQLSC-GSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWSV 2508
Query: 1158 CRSDEYNCSSGMCIRSSWV----CDGDNDCRDWSDEANC----------TAIYHTCEASN 1203
S +C G+ + + G + RD +C A++ +
Sbjct: 2509 WSSCSRSCGLGLTFQRQELLRPPLPGGSCPRDRFRSQSCFVQACPVAGAWAMWEAWGPCS 2568
Query: 1204 FQCRNGHCIPQRWACD-----GDTDCQDGSDE-DPVNCEKKCNGFRCPNGTCIPSSKHCD 1257
C GH QR D G C S E P + G C G S+ C
Sbjct: 2569 VSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPCGLQPCSGGTDCELGRVYVSADLCQ 2628
Query: 1258 -GL-----RDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAA 1311
GL C D + C C C+ L H C + +C E+
Sbjct: 2629 KGLVPPCPPSCLDPKANRSCSGHCVE----GCRCPPGLLLHDTRCLPLSECPCLVGEELK 2684
Query: 1312 FAG-------CSQDPEFHKVCDEFGFQCQNGVC 1337
+ G CSQ VC++ CQ G C
Sbjct: 2685 WPGVSFLLGNCSQ-----CVCEKGELLCQPGGC 2712
Score = 47.0 bits (110), Expect = 2e-04
Identities = 31/111 (27%), Positives = 40/111 (36%), Gaps = 31/111 (27%)
Query: 1332 CQNGVCISLIWKCDGMDDCGDYSDEANCEN------------------------------ 1361
C+ C+ CDG +DC D SDE +C
Sbjct: 2398 CEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMWLPSLPALWAASTVPFMMPTMALPGL 2457
Query: 1362 PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFS 1412
P CS Q C +G C+ +CD DC D SDE C D + P+S
Sbjct: 2458 PASRALCSPS-QLSCGSGECLSAERRCDLRPDCQDGSDEDGCVDCVLAPWS 2507
Score = 44.3 bits (103), Expect = 0.001
Identities = 21/48 (43%), Positives = 27/48 (56%), Gaps = 3/48 (6%)
Query: 1224 CQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHC 1271
C+ GS P+ C G RC +G C+ CDG+ DC DGSDE+ C
Sbjct: 2224 CEPGSPPAPL-CPGV--GLRCASGECVLRGGPCDGVLDCEDGSDEEGC 2268
Score = 39.3 bits (90), Expect = 0.043
Identities = 14/33 (42%), Positives = 20/33 (60%)
Query: 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDED 1231
C +C +G C+ + CDG DC+DGSDE+
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEE 2266
Score = 36.2 bits (82), Expect = 0.37
Identities = 15/38 (39%), Positives = 18/38 (47%)
Query: 1158 CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAI 1195
C C+SG C+ CDG DC D SDE C +
Sbjct: 2234 CPGVGLRCASGECVLRGGPCDGVLDCEDGSDEEGCVLL 2271
Score = 34.7 bits (78), Expect = 1.1
Identities = 60/279 (21%), Positives = 94/279 (33%), Gaps = 66/279 (23%)
Query: 1029 LCLPKANNSRSC----RCPEDVSSSVL-PSGDLMCDCPQGYQLKNNTCVKEENTCLRN-- 1081
LC + R C CP+ S+ P C G++L+ R
Sbjct: 4595 LCTAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPCSGGFRLRWREAEALCGGGCREPW 4654
Query: 1082 -QYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQES------------ 1128
Q C+ G C C+ + + CP + DL + +C +
Sbjct: 4655 AQESCNGGPCPE----CEAQDTVFTLDCANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQ 4710
Query: 1129 ----GTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDC- 1183
G C+P+S C CG S + E+ ++ + +C + C+ S VC +C
Sbjct: 4711 LVQDGRCVPIS-SCR----CGLPSANASWELAPAQAVQLDCQNCTCVNESLVCP-HQECP 4764
Query: 1184 --RDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGD---TDCQDGSDEDPVNCEKK 1238
WS ++C+A C G + + C+G CQ E ++
Sbjct: 4765 VLGPWSAWSSCSA---PC--------GGGTMERHRTCEGGPGVAPCQAQDTEQ----RQE 4809
Query: 1239 CNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTH 1277
CN CP C P L C+ C LC H
Sbjct: 4810 CNLQPCPE--CPPGQV----LSACATS-----CPCLCWH 4837
Score = 32.0 bits (71), Expect = 6.9
Identities = 15/43 (34%), Positives = 23/43 (53%), Gaps = 6/43 (13%)
Query: 1520 QCEDGEA------CIVLSERCDGFLDCSDESDEKACSDELTVY 1556
QC G+ C+ ++ CDG DC D SDE+ C+ L ++
Sbjct: 2390 QCGPGQTPCEVLGCVEQAQVCDGREDCLDGSDERHCARNLLMW 2432
>gi|61744467 low density lipoprotein receptor-related protein 8
isoform 3 precursor [Homo sapiens]
Length = 700
Score = 166 bits (420), Expect = 2e-40
Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 22/309 (7%)
Query: 755 AEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814
A ++ +++ R + R DL +L + L+ VALD + N +YW DL+ I
Sbjct: 289 AGKSPSLIFTNRHEVRRIDLVKRNYSRL-IPMLKNVVALDVEVATNRIYWCDLSYRKIYS 347
Query: 815 LCLNGSTG---QEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
++ ++ QEV+I+ L + E LA + + + +YW D+G K I VA DG R T+ +
Sbjct: 348 AYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 407
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
+ L PRA+ + P G M+W+DWGD + I +S ++G LVS++++WPNGI++D
Sbjct: 408 RN-LSEPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL 465
Query: 930 DQWIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRA 986
Q +YW D+ L + I FSG R ++ D L HP+ IAVF+++++W D +IF A
Sbjct: 466 SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 525
Query: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKN-TGSNAC--VPRP---CSLLCLPKANNSR-- 1038
++ +G ++ ILA L D+ IF++ K +AC +P C LCLP S
Sbjct: 526 NRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 585
Query: 1039 ---SCRCPE 1044
+C CP+
Sbjct: 586 PKYTCACPD 594
Score = 150 bits (380), Expect = 1e-35
Identities = 78/226 (34%), Positives = 113/226 (50%), Gaps = 27/226 (11%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
C ++Q++C N CI S+W CD D+DC D SDE +CP C D+ F C ++G CI +K
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTC-DNGHCIHERWK 104
Query: 1138 CDLEDDCGDNSDESH--CEMHQCRSDEYNC--SSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
CD E++C D SDES C C +++ +C +S C+ +SW CDG+ DC +DEA C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE------------DPVNCEKKCNG 1241
TC FQC +G C+ C+ + DC DGSDE + C C
Sbjct: 165 TSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTD 224
Query: 1242 FR------CPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDF 1281
+ CP G + K C + +C D C +C ++ +
Sbjct: 225 LKIGFECTCPAGFQLLDQKTCGDIDEC---KDPDACSQICVNYKGY 267
Score = 145 bits (365), Expect = 6e-34
Identities = 87/281 (30%), Positives = 124/281 (44%), Gaps = 60/281 (21%)
Query: 1113 PTTICDLDTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIR 1172
P C+ D QF+C+ CIP ++CD +DDC D+SDE C C ++ C +G CI
Sbjct: 43 PAKDCEKD-QFQCRNE-RCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDNGHCIH 100
Query: 1173 SSWVCDGDNDCRDWSDEANCTAIYHTCEASNFQC--RNGHCIPQRWACDGDTDCQDGSDE 1230
W CDG+ +C D SDE+ T C A C + C+P W CDG+ DC+ G+DE
Sbjct: 101 ERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADE 160
Query: 1231 DPVNCEKK---CNG--FRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKN 1285
C C G F+C +GTC+ + KHC+ +DC DGSDE C +
Sbjct: 161 --AGCATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGC-----------LQG 207
Query: 1286 RQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDE--FGFQCQNGVCISLIWK 1343
+CL ++ GCS +C + GF+C L+
Sbjct: 208 LNECLHNN-------------------GGCSH------ICTDLKIGFECTCPAGFQLL-- 240
Query: 1344 CDGMDDCGDYSDEANCENPTEAP----NCSRYFQFRCENGH 1380
CGD + C++P N YF+ C G+
Sbjct: 241 --DQKTCGDIDE---CKDPDACSQICVNYKGYFKCECYPGY 276
Score = 133 bits (334), Expect = 2e-30
Identities = 69/177 (38%), Positives = 89/177 (50%), Gaps = 23/177 (12%)
Query: 1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCV 1432
QF+C N CIP+ W+CD ++DC D SDE DC TC + + C +G C+
Sbjct: 51 QFQCRNERCIPSVWRCDEDDDCLDHSDEDDC-----------PKKTCADSDFTCDNGHCI 99
Query: 1433 MDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCD 1492
+ W CDG +C DGSDE A T P + C + C+P RCD
Sbjct: 100 HERWKCDGEEECPDGSDESE----ATCTKQVCPAEKLSCGPTSHK------CVPASWRCD 149
Query: 1493 GHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
G +DC+ G DEA C T S TC EFQC DG C++ + C+ DC D SDE C
Sbjct: 150 GEKDCEGGADEAGCAT-SLGTCRGDEFQCGDG-TCVLAIKHCNQEQDCPDGSDEAGC 204
Score = 42.4 bits (98), Expect = 0.005
Identities = 19/69 (27%), Positives = 34/69 (49%), Gaps = 1/69 (1%)
Query: 1071 CVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICD-LDTQFRCQESG 1129
C TC ++++C +G C+ +I C+ + DC D SDE C + + L C
Sbjct: 163 CATSLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHIC 222
Query: 1130 TCIPLSYKC 1138
T + + ++C
Sbjct: 223 TDLKIGFEC 231
>gi|66082554 low density lipoprotein receptor-related protein 8
isoform 2 precursor [Homo sapiens]
Length = 793
Score = 166 bits (420), Expect = 2e-40
Identities = 105/309 (33%), Positives = 170/309 (55%), Gaps = 22/309 (7%)
Query: 755 AEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQR 814
A ++ +++ R + R DL +L + L+ VALD + N +YW DL+ I
Sbjct: 248 AGKSPSLIFTNRHEVRRIDLVKRNYSRL-IPMLKNVVALDVEVATNRIYWCDLSYRKIYS 306
Query: 815 LCLNGSTG---QEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
++ ++ QEV+I+ L + E LA + + + +YW D+G K I VA DG R T+ +
Sbjct: 307 AYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFS 366
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
+ L PRA+ + P G M+W+DWGD + I +S ++G LVS++++WPNGI++D
Sbjct: 367 RN-LSEPRAIAVDPLRGFMYWSDWGD-QAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLL 424
Query: 930 DQWIYWTDAYLECIERITFSGQQRSVIL---DNLPHPYAIAVFKNEIYWDDWSQLSIFRA 986
Q +YW D+ L + I FSG R ++ D L HP+ IAVF+++++W D +IF A
Sbjct: 425 SQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSA 484
Query: 987 SKYSGSQMEILANQLTGLMDMKIFYKGKN-TGSNAC--VPRP---CSLLCLPKANNSR-- 1038
++ +G ++ ILA L D+ IF++ K +AC +P C LCLP S
Sbjct: 485 NRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHS 544
Query: 1039 ---SCRCPE 1044
+C CP+
Sbjct: 545 PKYTCACPD 553
Score = 120 bits (302), Expect = 1e-26
Identities = 69/208 (33%), Positives = 103/208 (49%), Gaps = 32/208 (15%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYK 1137
C ++Q++C N CI S+W CD D+DC D SDE +CP C D+ F C ++G CI +K
Sbjct: 47 CEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTC-ADSDFTC-DNGHCIHERWK 104
Query: 1138 CDLEDDCGDNSDESH--CEMHQCRSDEYNC--SSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
CD E++C D SDES C C +++ +C +S C+ +SW CDG+ DC +DEA C
Sbjct: 105 CDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCA 164
Query: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSS 1253
+ C +N C + C TD + G + C CP G +
Sbjct: 165 TWLNECLHNNGGCSH--------IC---TDLKIGFE---------CT---CPAGFQLLDQ 201
Query: 1254 KHCDGLRDCSDGSDEQHCEPLCTHFMDF 1281
K C + +C D C +C ++ +
Sbjct: 202 KTCGDIDEC---KDPDACSQICVNYKGY 226
Score = 114 bits (286), Expect = 8e-25
Identities = 76/224 (33%), Positives = 105/224 (46%), Gaps = 36/224 (16%)
Query: 1323 KVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCI 1382
K C++ FQC+N CI +W+CD DDC D+SDE +C T A + F C+NGHCI
Sbjct: 45 KDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADS-----DFTCDNGHCI 99
Query: 1383 PNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRC--SSGTCVMDTWVCDG 1440
RWKCD E +C D SDE + +T C C +S CV +W CDG
Sbjct: 100 HERWKCDGEEECPDGSDESE---------ATCTKQVCPAEKLSCGPTSHKCVPASWRCDG 150
Query: 1441 YRDCADGSDEEACPLLANVTAASTPTQLGRCD------RFEFECHQPKTCIPNWKRCDGH 1494
+DC G+DE C N + G C + FEC TC ++ D
Sbjct: 151 EKDCEGGADEAGCATWLNECLHNN----GGCSHICTDLKIGFEC----TCPAGFQLLD-Q 201
Query: 1495 QDCQDGRDEANCPTHSTLTCMSRE--FQCE--DGEACIVLSERC 1534
+ C D DE P + C++ + F+CE G +L++ C
Sbjct: 202 KTCGD-IDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNC 244
Score = 82.4 bits (202), Expect = 4e-15
Identities = 63/179 (35%), Positives = 76/179 (42%), Gaps = 25/179 (13%)
Query: 1234 NCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHS 1293
+CEK + F+C N CIPS CD DC D SDE C DF C N C+
Sbjct: 46 DCEK--DQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSDFTCDN-GHCIHER 102
Query: 1294 MVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQC--QNGVCISLIWKCDGMDDCG 1351
CDG +C DGSDE A C++ +VC C + C+ W+CDG DC
Sbjct: 103 WKCDGEEECPDGSDESE--ATCTK-----QVCPAEKLSCGPTSHKCVPASWRCDGEKDCE 155
Query: 1352 DYSDEANCENPTEAPNCSRYFQFRCENGHC--IPNRWKCDRENDCG---DWSDEKDCGD 1405
+DEA C T C NG C I K E C D+K CGD
Sbjct: 156 GGADEAGC--ATWLNECLH------NNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGD 206
Score = 79.0 bits (193), Expect = 5e-14
Identities = 60/190 (31%), Positives = 78/190 (41%), Gaps = 42/190 (22%)
Query: 1281 FVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISL 1340
F C+N ++C+ CD C D SDED C + K C + F C NG CI
Sbjct: 52 FQCRN-ERCIPSVWRCDEDDDCLDHSDED----DCPK-----KTCADSDFTCDNGHCIHE 101
Query: 1341 IWKCDGMDDCGDYSD--EANCEN---PTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCG 1395
WKCDG ++C D SD EA C P E +C + C+P W+CD E DC
Sbjct: 102 RWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGP------TSHKCVPASWRCDGEKDCE 155
Query: 1396 DWSDEKDC------------GDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRD 1443
+DE C G SHI G C +G ++D C +
Sbjct: 156 GGADEAGCATWLNECLHNNGGCSHICTDLKIGFEC------TCPAGFQLLDQKTCGDIDE 209
Query: 1444 CADGSDEEAC 1453
C D +AC
Sbjct: 210 C---KDPDAC 216
Score = 76.6 bits (187), Expect = 2e-13
Identities = 43/138 (31%), Positives = 60/138 (43%), Gaps = 17/138 (12%)
Query: 1415 GPST-CLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDR 1473
GP+ C + ++C + C+ W CD DC D SDE+ CP C
Sbjct: 42 GPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKT-------------CAD 88
Query: 1474 FEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQC-EDGEACIVLSE 1532
+F C WK CDG ++C DG DE+ T + C + + C C+ S
Sbjct: 89 SDFTCDNGHCIHERWK-CDGEEECPDGSDESEA-TCTKQVCPAEKLSCGPTSHKCVPASW 146
Query: 1533 RCDGFLDCSDESDEKACS 1550
RCDG DC +DE C+
Sbjct: 147 RCDGEKDCEGGADEAGCA 164
Score = 70.1 bits (170), Expect = 2e-11
Identities = 32/96 (33%), Positives = 50/96 (52%), Gaps = 4/96 (4%)
Query: 1075 ENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSD--ERNCPTTICDLDTQFRCQESGTCI 1132
+ TC + + C NG+CI+ W CD + +C D SD E C +C + S C+
Sbjct: 83 KKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCV 142
Query: 1133 PLSYKCDLEDDCGDNSDESHCE--MHQCRSDEYNCS 1166
P S++CD E DC +DE+ C +++C + CS
Sbjct: 143 PASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCS 178
>gi|11415040 matriptase [Homo sapiens]
Length = 855
Score = 130 bits (326), Expect = 2e-29
Identities = 67/156 (42%), Positives = 84/156 (53%), Gaps = 9/156 (5%)
Query: 1082 QYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQESGTCIPLSYKCDLE 1141
Q+ C G CI CD DC D SDE NC CD QF C+ C PL + CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNCS---CDAGHQFTCKNK-FCKPLFWVCDSV 511
Query: 1142 DDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAI-YHTCE 1200
+DCGDNSDE C C + + CS+G C+ S C+G +DC D SDEA+C + TC
Sbjct: 512 NDCGDNSDEQGCS---CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCT 568
Query: 1201 ASNFQCRNGHCIPQ-RWACDGDTDCQDGSDEDPVNC 1235
++C NG C+ + CDG DC DGSDE +C
Sbjct: 569 KHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCDC 604
Score = 123 bits (308), Expect = 2e-27
Identities = 65/158 (41%), Positives = 84/158 (53%), Gaps = 17/158 (10%)
Query: 1122 QFRCQESGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDN 1181
QF C+ +G CI +CD DC D+SDE +C ++ C + C WVCD N
Sbjct: 456 QFTCR-TGRCIRKELRCDGWADCTDHSDELNCSCDA--GHQFTCKNKFCKPLFWVCDSVN 512
Query: 1182 DCRDWSDEANCTAIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDE------DPVNC 1235
DC D SDE C+ C A F+C NG C+ + C+G DC DGSDE + V C
Sbjct: 513 DCGDNSDEQGCS-----CPAQTFRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTC 567
Query: 1236 EKKCNGFRCPNGTCIPSSK-HCDGLRDCSDGSDEQHCE 1272
K + +RC NG C+ CDG DCSDGSDE+ C+
Sbjct: 568 TK--HTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 117 bits (294), Expect = 1e-25
Identities = 64/174 (36%), Positives = 85/174 (48%), Gaps = 29/174 (16%)
Query: 1281 FVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISL 1340
F C+ + C+ + CDG C D SDE CS D F C+N C L
Sbjct: 457 FTCRTGR-CIRKELRCDGWADCTDHSDE----LNCSCDAGHQ-------FTCKNKFCKPL 504
Query: 1341 IWKCDGMDDCGDYSDEANCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
W CD ++DCGD SDE C P + FRC NG C+ +C+ ++DCGD SDE
Sbjct: 505 FWVCDSVNDCGDNSDEQGCSCPAQT--------FRCSNGKCLSKSQQCNGKDDCGDGSDE 556
Query: 1401 KDCGDSHILPFSTPGPSTCLPNYYRCSSGTCV-MDTWVCDGYRDCADGSDEEAC 1453
C +++ TC + YRC +G C+ CDG DC+DGSDE+ C
Sbjct: 557 ASCPKVNVV--------TCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 117 bits (293), Expect = 1e-25
Identities = 63/152 (41%), Positives = 78/152 (51%), Gaps = 13/152 (8%)
Query: 1162 EYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTAIYHTCEASN-FQCRNGHCIPQRWACDG 1220
++ C +G CIR CDG DC D SDE NC+ C+A + F C+N C P W CD
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNCS-----CDAGHQFTCKNKFCKPLFWVCDS 510
Query: 1221 DTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPL----CT 1276
DC D SDE +C + FRC NG C+ S+ C+G DC DGSDE C + CT
Sbjct: 511 VNDCGDNSDEQGCSCPAQT--FRCSNGKCLSKSQQCNGKDDCGDGSDEASCPKVNVVTCT 568
Query: 1277 HFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE 1308
+ C N + CDG C DGSDE
Sbjct: 569 KH-TYRCLNGLCLSKGNPECDGKEDCSDGSDE 599
Score = 114 bits (284), Expect = 1e-24
Identities = 62/177 (35%), Positives = 80/177 (45%), Gaps = 30/177 (16%)
Query: 1373 QFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCV 1432
QF C G CI +CD DC D SDE +C S + + C + C
Sbjct: 456 QFTCRTGRCIRKELRCDGWADCTDHSDELNC-------------SCDAGHQFTCKNKFCK 502
Query: 1433 MDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCD 1492
WVCD DC D SDE+ C S P Q RC + C+ ++C+
Sbjct: 503 PLFWVCDSVNDCGDNSDEQGC---------SCPAQTFRCSNGK--------CLSKSQQCN 545
Query: 1493 GHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
G DC DG DEA+CP + +TC ++C +G + CDG DCSD SDEK C
Sbjct: 546 GKDDCGDGSDEASCPKVNVVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDC 602
Score = 108 bits (270), Expect = 6e-23
Identities = 67/160 (41%), Positives = 85/160 (53%), Gaps = 16/160 (10%)
Query: 1204 FQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCS 1263
F CR G CI + CDG DC D SDE +C+ + F C N C P CD + DC
Sbjct: 457 FTCRTGRCIRKELRCDGWADCTDHSDELNCSCDAG-HQFTCKNKFCKPLFWVCDSVNDCG 515
Query: 1264 DGSDEQHCE-PLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFH 1322
D SDEQ C P T F C N + CL S C+G C DGSDE A C P+ +
Sbjct: 516 DNSDEQGCSCPAQT----FRCSNGK-CLSKSQQCNGKDDCGDGSDE----ASC---PKVN 563
Query: 1323 KV-CDEFGFQCQNGVCISL-IWKCDGMDDCGDYSDEANCE 1360
V C + ++C NG+C+S +CDG +DC D SDE +C+
Sbjct: 564 VVTCTKHTYRCLNGLCLSKGNPECDGKEDCSDGSDEKDCD 603
Score = 69.3 bits (168), Expect = 4e-11
Identities = 56/189 (29%), Positives = 81/189 (42%), Gaps = 42/189 (22%)
Query: 1053 SGDLMCDCPQGYQL--KNNTCV-----------------KEENTCLRNQYRCSNGNCINS 1093
S +L C C G+Q KN C ++ +C +RCSNG C++
Sbjct: 481 SDELNCSCDAGHQFTCKNKFCKPLFWVCDSVNDCGDNSDEQGCSCPAQTFRCSNGKCLSK 540
Query: 1094 IWWCDFDNDCGDMSDERNCP---TTICDLDTQFRCQESGTCIPL-SYKCDLEDDCGDNSD 1149
C+ +DCGD SDE +CP C T +RC +G C+ + +CD ++DC D SD
Sbjct: 541 SQQCNGKDDCGDGSDEASCPKVNVVTCTKHT-YRCL-NGLCLSKGNPECDGKEDCSDGSD 598
Query: 1150 ESHCEMHQCRSDEYNCSSGMCIRSSWVCDG-DNDCRDWSDEANCTAI--YHTCEAS---- 1202
E C+ C R + V G D D +W + + A+ H C AS
Sbjct: 599 EKDCD----------CGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISP 648
Query: 1203 NFQCRNGHC 1211
N+ HC
Sbjct: 649 NWLVSAAHC 657
Score = 53.1 bits (126), Expect = 3e-06
Identities = 30/86 (34%), Positives = 40/86 (46%), Gaps = 7/86 (8%)
Query: 1475 EFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERC 1534
+F C + CI RCDG DC D DE NC + +F C++ + C L C
Sbjct: 456 QFTCRTGR-CIRKELRCDGWADCTDHSDELNCSCDA-----GHQFTCKN-KFCKPLFWVC 508
Query: 1535 DGFLDCSDESDEKACSDELTVYKVQN 1560
D DC D SDE+ CS ++ N
Sbjct: 509 DSVNDCGDNSDEQGCSCPAQTFRCSN 534
>gi|126012571 heparan sulfate proteoglycan 2 [Homo sapiens]
Length = 4391
Score = 127 bits (320), Expect = 9e-29
Identities = 78/250 (31%), Positives = 97/250 (38%), Gaps = 63/250 (25%)
Query: 1319 PEFHKVCDEFGFQCQN-GVCISLIWKCDGMDDCGDYSDEANCENP--------------- 1362
P+F + C E F C + C++L ++CD DC D SDE NCE P
Sbjct: 193 PQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETT 252
Query: 1363 ----------------TEAPN-----------CSRYFQFRCENGHCIPNRWKCDRENDCG 1395
T AP C + C NGHCIP + CD + DC
Sbjct: 253 SLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQ-EAACRNGHCIPRDYLCDGQEDCE 311
Query: 1396 DWSDEKDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPL 1455
D SDE DCG P C PN + C +G C + W CDG DC D +DE CP
Sbjct: 312 DGSDELDCGP----------PPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCP- 360
Query: 1456 LANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCM 1515
P ++ C +F C CIP CD DC D DE C +T
Sbjct: 361 ------TKRPEEV--CGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPP 412
Query: 1516 SREFQCEDGE 1525
Q G+
Sbjct: 413 RESIQASRGQ 422
Score = 121 bits (303), Expect = 9e-27
Identities = 73/208 (35%), Positives = 88/208 (42%), Gaps = 57/208 (27%)
Query: 1120 DTQFRCQESGTCIPLSYKCDLEDDCGDNSDESHCE------------------------- 1154
+ +F C C+ L Y+CD DC D SDE +CE
Sbjct: 201 EAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPRPET 260
Query: 1155 --MHQ-------------------CRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
M Q C E C +G CI ++CDG DC D SDE +C
Sbjct: 261 TIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDELDC- 319
Query: 1194 AIYHTCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNC-----EKKC--NGFRC-P 1245
CE + F C NGHC + W CDGD DC+D +DE NC E+ C FRC
Sbjct: 320 GPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDE--ANCPTKRPEEVCGPTQFRCVS 377
Query: 1246 NGTCIPSSKHCDGLRDCSDGSDEQHCEP 1273
CIP+S HCD DC D SDE C P
Sbjct: 378 TNMCIPASFHCDEESDCPDRSDEFGCMP 405
Score = 108 bits (269), Expect = 8e-23
Identities = 69/220 (31%), Positives = 91/220 (41%), Gaps = 50/220 (22%)
Query: 1061 PQGYQLKN-NTCVKEENTCLRNQYRCSNGN-CINSIWWCDFDNDCGDMSDERNCPTTICD 1118
PQG+Q + T + C ++ C + N C+ + CD DC DMSDE NC +
Sbjct: 181 PQGFQFRRLGTVPQFPRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLG 240
Query: 1119 LDTQFRC----------------------------------------QE----SGTCIPL 1134
+ F QE +G CIP
Sbjct: 241 ISPTFSLLVETTSLPPRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPR 300
Query: 1135 SYKCDLEDDCGDNSDESHC-EMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCT 1193
Y CD ++DC D SDE C C +E+ C +G C W CDGD DC D +DEANC
Sbjct: 301 DYLCDGQEDCEDGSDELDCGPPPPCEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANCP 360
Query: 1194 A--IYHTCEASNFQC-RNGHCIPQRWACDGDTDCQDGSDE 1230
C + F+C CIP + CD ++DC D SDE
Sbjct: 361 TKRPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDE 400
Score = 104 bits (260), Expect = 8e-22
Identities = 75/219 (34%), Positives = 95/219 (43%), Gaps = 28/219 (12%)
Query: 1199 CEASNFQCRN-GHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFR-----CPNGTCIPS 1252
C + F C + C+ + CD DC+D SDE +NCE+ G T +P
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDE--LNCEEPVLGISPTFSLLVETTSLPP 256
Query: 1253 SKHCDGLRDCSDGSDEQ-----HCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSD 1307
+R Q PL + C+N C+ +CDG C DGSD
Sbjct: 257 RPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGH-CIPRDYLCDGQEDCEDGSD 315
Query: 1308 EDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPN 1367
E C P C+ F C NG C +W+CDG DC D +DEANC PT+ P
Sbjct: 316 E----LDCGPPPP----CEPNEFPCGNGHCALKLWRCDGDFDCEDRTDEANC--PTKRPE 365
Query: 1368 --CSRYFQFRC-ENGHCIPNRWKCDRENDCGDWSDEKDC 1403
C QFRC CIP + CD E+DC D SDE C
Sbjct: 366 EVCGP-TQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 104 bits (259), Expect = 1e-21
Identities = 69/221 (31%), Positives = 86/221 (38%), Gaps = 50/221 (22%)
Query: 1366 PNCSRYFQFRCEN-GHCIPNRWKCDRENDCGDWSDEKDCGD------------------- 1405
P +F C + C+ ++CDR DC D SDE +C +
Sbjct: 196 PRACTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLP 255
Query: 1406 -------------SHILPFSTPG---PSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSD 1449
+H PG P C P C +G C+ ++CDG DC DGSD
Sbjct: 256 PRPETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSD 315
Query: 1450 EEACPLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPT- 1508
E C P C+ EF C + W RCDG DC+D DEANCPT
Sbjct: 316 ELDC-------GPPPP-----CEPNEFPCGNGHCALKLW-RCDGDFDCEDRTDEANCPTK 362
Query: 1509 HSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDESDEKAC 1549
C +F+C CI S CD DC D SDE C
Sbjct: 363 RPEEVCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGC 403
Score = 101 bits (252), Expect = 7e-21
Identities = 81/260 (31%), Positives = 101/260 (38%), Gaps = 52/260 (20%)
Query: 1275 CTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE---DAAFAGCS--------------- 1316
CT +F C + +C+ CD CRD SDE + G S
Sbjct: 199 CTE-AEFACHSYNECVALEYRCDRRPDCRDMSDELNCEEPVLGISPTFSLLVETTSLPPR 257
Query: 1317 -------QDPEFHKV------------CDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEA 1357
Q P H C C+NG CI + CDG +DC D SDE
Sbjct: 258 PETTIMRQPPVTHAPQPLLPGSVRPLPCGPQEAACRNGHCIPRDYLCDGQEDCEDGSDEL 317
Query: 1358 NCENPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPS 1417
+C P P C +F C NGHC W+CD + DC D +DE +C P P
Sbjct: 318 DCGPP---PPCEPN-EFPCGNGHCALKLWRCDGDFDCEDRTDEANC------PTKRP-EE 366
Query: 1418 TCLPNYYRC-SSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEF 1476
C P +RC S+ C+ ++ CD DC D SDE C VT Q R F
Sbjct: 367 VCGPTQFRCVSTNMCIPASFHCDEESDCPDRSDEFGCMPPQVVTPPRESIQASRGQTVTF 426
Query: 1477 ECHQ--PKTCIPNWKRCDGH 1494
C T I NW+ GH
Sbjct: 427 TCVAIGVPTPIINWRLNWGH 446
Score = 87.0 bits (214), Expect = 2e-16
Identities = 50/133 (37%), Positives = 62/133 (46%), Gaps = 10/133 (7%)
Query: 1025 PCSLLCLPKANNSRSCRCPEDVSSSVLPSGDLMCDCPQGYQLKNNTCVKEENTCLRNQYR 1084
P S+ LP +CR + L G DC G + C N++
Sbjct: 277 PGSVRPLPCGPQEAACRNGHCIPRDYLCDGQE--DCEDG---SDELDCGPPPPCEPNEFP 331
Query: 1085 CSNGNCINSIWWCDFDNDCGDMSDERNCPT----TICDLDTQFRCQESGTCIPLSYKCDL 1140
C NG+C +W CD D DC D +DE NCPT +C TQFRC + CIP S+ CD
Sbjct: 332 CGNGHCALKLWRCDGDFDCEDRTDEANCPTKRPEEVCG-PTQFRCVSTNMCIPASFHCDE 390
Query: 1141 EDDCGDNSDESHC 1153
E DC D SDE C
Sbjct: 391 ESDCPDRSDEFGC 403
Score = 38.5 bits (88), Expect = 0.074
Identities = 16/38 (42%), Positives = 18/38 (47%)
Query: 1514 CMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSD 1551
C EF C C+ L RCD DC D SDE C +
Sbjct: 199 CTEAEFACHSYNECVALEYRCDRRPDCRDMSDELNCEE 236
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 124 bits (312), Expect = 8e-28
Identities = 74/230 (32%), Positives = 118/230 (51%), Gaps = 4/230 (1%)
Query: 791 VALDFDYEHNCLYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVD 850
V +D+D +YW+D+A I R L E I+NSGL + E LA + + + +YW D
Sbjct: 1145 VGIDYDCRERMVYWTDVAGRTISRAGLELGAEPETIVNSGLISPEGLAIDHIRRTMYWTD 1204
Query: 851 AGFKKIEVANPDGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGS 910
+ KIE A DG R + + +++ PRA+ + P G ++WTDW P I S++DG
Sbjct: 1205 SVLDKIESALLDGSERKVLFYTDLVN-PRAIAVDPIRGNLYWTDWNREAPKIETSSLDGE 1263
Query: 911 AAYHLVSEDVKWPNGISVD--DQWIYWTDAYLECIERITFSGQQRSVILDNLPHPYAIAV 968
L++ D+ PNG++ D + + W DA + +E G R VI +NL +P++I
Sbjct: 1264 NRRILINTDIGLPNGLTFDPFSKLLCWADAGTKKLECTLPDGTGRRVIQNNLKYPFSIVS 1323
Query: 969 FKNEIYWDDWSQLSIFRASKYSGS-QMEILANQLTGLMDMKIFYKGKNTG 1017
+ + Y DW + + +K+SG E L Q + L + Y TG
Sbjct: 1324 YADHFYHTDWRRDGVVSVNKHSGQFTDEYLPEQRSHLYGITAVYPYCPTG 1373
Score = 38.9 bits (89), Expect = 0.057
Identities = 70/305 (22%), Positives = 101/305 (33%), Gaps = 70/305 (22%)
Query: 1055 DLMCDCPQGYQLKNNTCVKEENTCLRNQYRCS-NGNCIN--SIWWCDFDNDCGDMSDERN 1111
D C+C GYQ CV +EN C +RC N CIN + C+ + D
Sbjct: 783 DYTCECASGYQGDGRNCV-DENECATGFHRCGPNSVCINLPGSYRCECRSGYEFADDRHT 841
Query: 1112 C-----PTTICDLDTQFRCQESG--TCI-----PLSYKCDLEDDCGDNSDESHCEMHQCR 1159
C P C+ D C +G C+ S C L GD HQC
Sbjct: 842 CILITPPANPCE-DGSHTCAPAGQARCVHHGGSTFSCAC-LPGYAGDG--------HQC- 890
Query: 1160 SDEYNCSSGMC--IRSSWVCDGDNDCR----DWSDEANC----TAIYHTCEASNFQCRNG 1209
+D CS C + + G CR + D C T+ CE +
Sbjct: 891 TDVDECSENRCHPAATCYNTPGSFSCRCQPGYYGDGFQCIPDSTSSLTPCEQQQRHAQAQ 950
Query: 1210 HCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRC--PNGTCIPSSKHCDGLRDCSDGSD 1267
+ P A C + + P+ C C P+G +P ++ GS
Sbjct: 951 YAYP--GARFHIPQCDEQGNFLPLQCHGSTGFCWCVDPDGHEVPGTQ-------TPPGST 1001
Query: 1268 EQHC--EPLCTHFMDFVCKN-RQQCLFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKV 1324
HC P T +C+ R+ L H + G +D ++
Sbjct: 1002 PPHCGPSPEPTQRPPTICERWRENLLEH-------------------YGGTPRDDQYVPQ 1042
Query: 1325 CDEFG 1329
CD+ G
Sbjct: 1043 CDDLG 1047
>gi|208973262 low density lipoprotein-related protein 12 isoform b
precursor [Homo sapiens]
Length = 840
Score = 124 bits (311), Expect = 1e-27
Identities = 99/356 (27%), Positives = 138/356 (38%), Gaps = 82/356 (23%)
Query: 1154 EMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCT--------AIYHTCEASNFQ 1205
E C D++ C +G CI +W C+ ++C D SDE C A + C + FQ
Sbjct: 143 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 202
Query: 1206 CRNGH-----CIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---------FRCPN-GTCI 1250
C + C+P+ CDG+ DC D DE ++C+ G F PN
Sbjct: 203 CLSRFTKVYTCLPESLKCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSPNYPDFY 260
Query: 1251 PSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKN---------------------RQQC 1289
P +C L D D + F DF R
Sbjct: 261 PPGSNCTWLIDTGDH------RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 314
Query: 1290 LFHS------MVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQ-NGVCISLIW 1342
F S + G I+ +D+ A G + + C + C N C +
Sbjct: 315 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQ 374
Query: 1343 KCDGMDDCGDYSDEANCE--NPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
+CDG C + DE NC E P CSR NG C P +C+ +N C + SDE
Sbjct: 375 RCDGYWHCPNGRDETNCTMCQKEEFP-CSR-------NGVCYPRSDRCNYQNHCPNGSDE 426
Query: 1401 KDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLL 1456
K+C C P + C + CV ++WVCD DC DGSDEE CP++
Sbjct: 427 KNC-------------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 469
Score = 114 bits (284), Expect = 1e-24
Identities = 98/351 (27%), Positives = 136/351 (38%), Gaps = 68/351 (19%)
Query: 1062 QGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC-----PTTI 1116
+G++L + EE C +Q+RC NG CI W C+ ++CGD SDE C P T
Sbjct: 131 KGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTA 190
Query: 1117 CDLD----TQFRC----QESGTCIPLSYKCDLEDDCGDNSDESHCEMHQC---------- 1158
QF+C + TC+P S KCD DC D DE C++ C
Sbjct: 191 AAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGT 250
Query: 1159 -RSDEYNCSSGMCIRSSWVCD-GDN--------DCR-DWSDEANCTAIYHTCEASNFQ-- 1205
S Y +W+ D GD+ D + D + + IY E + +
Sbjct: 251 FNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLL 310
Query: 1206 ----CRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIP---------- 1251
+ H + G +D+ VN + N +G C+P
Sbjct: 311 RVLTAFDSHAPLTVVSSSGQIRVHFCADK--VNAARGFNATYQVDGFCLPWEIPCGGNWG 368
Query: 1252 ---SSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE 1308
+ CDG C +G DE +C +C +F C C S C+ C +GSDE
Sbjct: 369 CYTEQQRCDGYWHCPNGRDETNC-TMCQK-EEFPCSRNGVCYPRSDRCNYQNHCPNGSDE 426
Query: 1309 DAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
F C F C+N C+ W CD DDCGD SDE NC
Sbjct: 427 KNCF-----------FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 466
Score = 111 bits (278), Expect = 7e-24
Identities = 91/307 (29%), Positives = 116/307 (37%), Gaps = 80/307 (26%)
Query: 1310 AAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCS 1369
A F+G S++P CD+F +C NG CI WKC+ MD+CGD SDE C P +
Sbjct: 136 AYFSGKSEEPNC--ACDQF--RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 191
Query: 1370 -----RYFQFRCENGH-----CIPNRWKCDRENDCGDWSDEKDCG----DSHILPFSTPG 1415
Y QF+C + C+P KCD DC D DE DC + F
Sbjct: 192 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 251
Query: 1416 PSTCLPNYYRCSSGTCVMDTWVCD-------------------GYRDCA---DGSDEEAC 1453
S P++Y S TW+ D GY D DG +E
Sbjct: 252 NSPNYPDFYPPGSNC----TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPH 307
Query: 1454 PLLANVTAASTPTQL-------------------------------GRCDRFEFECHQPK 1482
LL +TA + L G C +E C
Sbjct: 308 KLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNW 367
Query: 1483 TCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSD 1542
C +RCDG+ C +GRDE NC C EF C C S+RC+ C +
Sbjct: 368 GCYTEQQRCDGYWHCPNGRDETNC-----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPN 422
Query: 1543 ESDEKAC 1549
SDEK C
Sbjct: 423 GSDEKNC 429
Score = 87.8 bits (216), Expect = 1e-16
Identities = 87/354 (24%), Positives = 125/354 (35%), Gaps = 78/354 (22%)
Query: 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG-------------FRCP 1245
C F+C NG CIP+ W C+ +C D SDE+ C K+ N F+C
Sbjct: 147 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI--CAKEANPPTAAAFQPCAYNQFQCL 204
Query: 1246 NG-----TCIPSSKHCDGLRDCSDGSDEQHCE-PLCTHFMD-----FVCKNRQQCLFHSM 1294
+ TC+P S CDG DC D DE C+ P C ++ F N
Sbjct: 205 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 264
Query: 1295 VCDGIIQCRDGSDEDAAFAGCSQDP----EFHKVCDEFGFQCQNGVCISLIWKCDG---- 1346
C +I D F D ++ K+ D G + + ++ D
Sbjct: 265 NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYD--GLEENPHKLLRVLTAFDSHAPL 322
Query: 1347 ----------MDDCGDYSDEANCENPT-EAPNCSRYFQFRCE-NGHCIPNRWKCDRENDC 1394
+ C D + A N T + ++ C N C + +CD C
Sbjct: 323 TVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHC 382
Query: 1395 GDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCS-SGTCVMDTWVCDGYRDCADGSDEEAC 1453
+ DE +C + C + CS +G C + C+ C +GSDE+ C
Sbjct: 383 PNGRDETNC-------------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 429
Query: 1454 PLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCP 1507
C F C + +W CD DC DG DE NCP
Sbjct: 430 FF---------------CQPGNFHCKNNRCVFESWV-CDSQDDCGDGSDEENCP 467
Score = 87.4 bits (215), Expect = 1e-16
Identities = 45/131 (34%), Positives = 65/131 (49%), Gaps = 6/131 (4%)
Query: 1069 NTCVKEENTCLRNQYRCS-NGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQE 1127
N + + CL + C N C CD C + DE NC T+C + +F C
Sbjct: 347 NATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNC--TMCQKE-EFPCSR 403
Query: 1128 SGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWS 1187
+G C P S +C+ ++ C + SDE +C C+ ++C + C+ SWVCD +DC D S
Sbjct: 404 NGVCYPRSDRCNYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGS 461
Query: 1188 DEANCTAIYHT 1198
DE NC I T
Sbjct: 462 DEENCPVIVPT 472
Score = 70.9 bits (172), Expect = 1e-11
Identities = 42/132 (31%), Positives = 53/132 (40%), Gaps = 22/132 (16%)
Query: 1419 CLPNYYRCSSGT-CVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFE 1477
CLP C C + CDGY C +G DE C + C + EF
Sbjct: 356 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM---------------CQKEEFP 400
Query: 1478 CHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGF 1537
C + C P RC+ C +G DE NC C F C++ C+ S CD
Sbjct: 401 CSRNGVCYPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHCKNNR-CVFESWVCDSQ 454
Query: 1538 LDCSDESDEKAC 1549
DC D SDE+ C
Sbjct: 455 DDCGDGSDEENC 466
Score = 42.0 bits (97), Expect = 0.007
Identities = 32/98 (32%), Positives = 39/98 (39%), Gaps = 33/98 (33%)
Query: 1025 PCSL--LCLPKANNSRSCRCPEDVSSSVLPSGDLMCDC----PQGYQLKNNTCVKEENTC 1078
PCS +C P RS RC + P+G +C P + KNN CV E
Sbjct: 400 PCSRNGVCYP-----RSDRCNYQ---NHCPNGSDEKNCFFCQPGNFHCKNNRCVFES--- 448
Query: 1079 LRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTI 1116
W CD +DCGD SDE NCP +
Sbjct: 449 ----------------WVCDSQDDCGDGSDEENCPVIV 470
Score = 34.3 bits (77), Expect = 1.4
Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%)
Query: 1514 CMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDE 1552
C +F+C +G+ CI + +C+ +C D SDE+ C+ E
Sbjct: 147 CACDQFRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKE 184
>gi|7305525 low density lipoprotein-related protein 12 isoform a
precursor [Homo sapiens]
Length = 859
Score = 124 bits (311), Expect = 1e-27
Identities = 99/356 (27%), Positives = 138/356 (38%), Gaps = 82/356 (23%)
Query: 1154 EMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCT--------AIYHTCEASNFQ 1205
E C D++ C +G CI +W C+ ++C D SDE C A + C + FQ
Sbjct: 162 EEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQ 221
Query: 1206 CRNGH-----CIPQRWACDGDTDCQDGSDEDPVNCEKKCNG---------FRCPN-GTCI 1250
C + C+P+ CDG+ DC D DE ++C+ G F PN
Sbjct: 222 CLSRFTKVYTCLPESLKCDGNIDCLDLGDE--IDCDVPTCGQWLKYFYGTFNSPNYPDFY 279
Query: 1251 PSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKN---------------------RQQC 1289
P +C L D D + F DF R
Sbjct: 280 PPGSNCTWLIDTGDH------RKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLT 333
Query: 1290 LFHS------MVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQ-NGVCISLIW 1342
F S + G I+ +D+ A G + + C + C N C +
Sbjct: 334 AFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQ 393
Query: 1343 KCDGMDDCGDYSDEANCE--NPTEAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDE 1400
+CDG C + DE NC E P CSR NG C P +C+ +N C + SDE
Sbjct: 394 RCDGYWHCPNGRDETNCTMCQKEEFP-CSR-------NGVCYPRSDRCNYQNHCPNGSDE 445
Query: 1401 KDCGDSHILPFSTPGPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLL 1456
K+C C P + C + CV ++WVCD DC DGSDEE CP++
Sbjct: 446 KNC-------------FFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI 488
Score = 114 bits (284), Expect = 1e-24
Identities = 98/351 (27%), Positives = 136/351 (38%), Gaps = 68/351 (19%)
Query: 1062 QGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC-----PTTI 1116
+G++L + EE C +Q+RC NG CI W C+ ++CGD SDE C P T
Sbjct: 150 KGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTA 209
Query: 1117 CDLD----TQFRC----QESGTCIPLSYKCDLEDDCGDNSDESHCEMHQC---------- 1158
QF+C + TC+P S KCD DC D DE C++ C
Sbjct: 210 AAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGT 269
Query: 1159 -RSDEYNCSSGMCIRSSWVCD-GDN--------DCR-DWSDEANCTAIYHTCEASNFQ-- 1205
S Y +W+ D GD+ D + D + + IY E + +
Sbjct: 270 FNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLL 329
Query: 1206 ----CRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNGFRCPNGTCIP---------- 1251
+ H + G +D+ VN + N +G C+P
Sbjct: 330 RVLTAFDSHAPLTVVSSSGQIRVHFCADK--VNAARGFNATYQVDGFCLPWEIPCGGNWG 387
Query: 1252 ---SSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGIIQCRDGSDE 1308
+ CDG C +G DE +C +C +F C C S C+ C +GSDE
Sbjct: 388 CYTEQQRCDGYWHCPNGRDETNC-TMCQK-EEFPCSRNGVCYPRSDRCNYQNHCPNGSDE 445
Query: 1309 DAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANC 1359
F C F C+N C+ W CD DDCGD SDE NC
Sbjct: 446 KNCF-----------FCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENC 485
Score = 111 bits (278), Expect = 7e-24
Identities = 91/307 (29%), Positives = 116/307 (37%), Gaps = 80/307 (26%)
Query: 1310 AAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPTEAPNCS 1369
A F+G S++P CD+F +C NG CI WKC+ MD+CGD SDE C P +
Sbjct: 155 AYFSGKSEEPNC--ACDQF--RCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAA 210
Query: 1370 -----RYFQFRCENGH-----CIPNRWKCDRENDCGDWSDEKDCG----DSHILPFSTPG 1415
Y QF+C + C+P KCD DC D DE DC + F
Sbjct: 211 AFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTF 270
Query: 1416 PSTCLPNYYRCSSGTCVMDTWVCD-------------------GYRDCA---DGSDEEAC 1453
S P++Y S TW+ D GY D DG +E
Sbjct: 271 NSPNYPDFYPPGSNC----TWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPH 326
Query: 1454 PLLANVTAASTPTQL-------------------------------GRCDRFEFECHQPK 1482
LL +TA + L G C +E C
Sbjct: 327 KLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNW 386
Query: 1483 TCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSD 1542
C +RCDG+ C +GRDE NC C EF C C S+RC+ C +
Sbjct: 387 GCYTEQQRCDGYWHCPNGRDETNC-----TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPN 441
Query: 1543 ESDEKAC 1549
SDEK C
Sbjct: 442 GSDEKNC 448
Score = 87.8 bits (216), Expect = 1e-16
Identities = 87/354 (24%), Positives = 125/354 (35%), Gaps = 78/354 (22%)
Query: 1199 CEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCNG-------------FRCP 1245
C F+C NG CIP+ W C+ +C D SDE+ C K+ N F+C
Sbjct: 166 CACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEI--CAKEANPPTAAAFQPCAYNQFQCL 223
Query: 1246 NG-----TCIPSSKHCDGLRDCSDGSDEQHCE-PLCTHFMD-----FVCKNRQQCLFHSM 1294
+ TC+P S CDG DC D DE C+ P C ++ F N
Sbjct: 224 SRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGS 283
Query: 1295 VCDGIIQCRDGSDEDAAFAGCSQDP----EFHKVCDEFGFQCQNGVCISLIWKCDG---- 1346
C +I D F D ++ K+ D G + + ++ D
Sbjct: 284 NCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYD--GLEENPHKLLRVLTAFDSHAPL 341
Query: 1347 ----------MDDCGDYSDEANCENPT-EAPNCSRYFQFRCE-NGHCIPNRWKCDRENDC 1394
+ C D + A N T + ++ C N C + +CD C
Sbjct: 342 TVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHC 401
Query: 1395 GDWSDEKDCGDSHILPFSTPGPSTCLPNYYRCS-SGTCVMDTWVCDGYRDCADGSDEEAC 1453
+ DE +C + C + CS +G C + C+ C +GSDE+ C
Sbjct: 402 PNGRDETNC-------------TMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNC 448
Query: 1454 PLLANVTAASTPTQLGRCDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCP 1507
C F C + +W CD DC DG DE NCP
Sbjct: 449 FF---------------CQPGNFHCKNNRCVFESWV-CDSQDDCGDGSDEENCP 486
Score = 87.4 bits (215), Expect = 1e-16
Identities = 45/131 (34%), Positives = 65/131 (49%), Gaps = 6/131 (4%)
Query: 1069 NTCVKEENTCLRNQYRCS-NGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQE 1127
N + + CL + C N C CD C + DE NC T+C + +F C
Sbjct: 366 NATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNC--TMCQKE-EFPCSR 422
Query: 1128 SGTCIPLSYKCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWS 1187
+G C P S +C+ ++ C + SDE +C C+ ++C + C+ SWVCD +DC D S
Sbjct: 423 NGVCYPRSDRCNYQNHCPNGSDEKNCFF--CQPGNFHCKNNRCVFESWVCDSQDDCGDGS 480
Query: 1188 DEANCTAIYHT 1198
DE NC I T
Sbjct: 481 DEENCPVIVPT 491
Score = 70.9 bits (172), Expect = 1e-11
Identities = 42/132 (31%), Positives = 53/132 (40%), Gaps = 22/132 (16%)
Query: 1419 CLPNYYRCSSGT-CVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFE 1477
CLP C C + CDGY C +G DE C + C + EF
Sbjct: 375 CLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTM---------------CQKEEFP 419
Query: 1478 CHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGF 1537
C + C P RC+ C +G DE NC C F C++ C+ S CD
Sbjct: 420 CSRNGVCYPRSDRCNYQNHCPNGSDEKNC-----FFCQPGNFHCKNNR-CVFESWVCDSQ 473
Query: 1538 LDCSDESDEKAC 1549
DC D SDE+ C
Sbjct: 474 DDCGDGSDEENC 485
Score = 42.0 bits (97), Expect = 0.007
Identities = 32/98 (32%), Positives = 39/98 (39%), Gaps = 33/98 (33%)
Query: 1025 PCSL--LCLPKANNSRSCRCPEDVSSSVLPSGDLMCDC----PQGYQLKNNTCVKEENTC 1078
PCS +C P RS RC + P+G +C P + KNN CV E
Sbjct: 419 PCSRNGVCYP-----RSDRCNYQ---NHCPNGSDEKNCFFCQPGNFHCKNNRCVFES--- 467
Query: 1079 LRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTI 1116
W CD +DCGD SDE NCP +
Sbjct: 468 ----------------WVCDSQDDCGDGSDEENCPVIV 489
Score = 34.3 bits (77), Expect = 1.4
Identities = 14/39 (35%), Positives = 24/39 (61%), Gaps = 1/39 (2%)
Query: 1514 CMSREFQCEDGEACIVLSERCDGFLDCSDESDEKACSDE 1552
C +F+C +G+ CI + +C+ +C D SDE+ C+ E
Sbjct: 166 CACDQFRCGNGK-CIPEAWKCNNMDECGDSSDEEICAKE 203
>gi|166362728 epidermal growth factor (beta-urogastrone) [Homo
sapiens]
Length = 1207
Score = 123 bits (309), Expect = 2e-27
Identities = 125/478 (26%), Positives = 200/478 (41%), Gaps = 43/478 (8%)
Query: 752 CPLAEENEFILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDV 811
C + F+L+A + I L + ALD D N +Y++ AL
Sbjct: 476 CAASGPQPFLLFANSQDIRHMHFDGTDYGTLLSQQMGMVYALDHDPVENKIYFAHTALKW 535
Query: 812 IQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVN 871
I+R ++GS +E +I G++ E LA + + + YW D G I ++ +G R I+
Sbjct: 536 IERANMDGSQ-RERLIEEGVDVPEGLAVDWIGRRFYWTDRGKSLIGRSDLNGK-RSKIIT 593
Query: 872 SSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD-- 929
+ +PR + + P +FWTD G + P I S++ G + S D+ WP+GI++D
Sbjct: 594 KENISQPRGIAVHPMAKRLFWTDTG-INPRIESSSLQGLGRLVIASSDLIWPSGITIDFL 652
Query: 930 DQWIYWTDAYLECIERITFSGQQRSVILDN-LPHPYAIAVFKNEIYWDDWSQLSIFRASK 988
+YW DA IE G +R + N + HP+A+AVF++ +++ DW+ S+ R +K
Sbjct: 653 TDKLYWCDAKQSVIEMANLDGSKRRRLTQNDVGHPFAVAVFEDYVWFSDWAMPSVMRVNK 712
Query: 989 YSGSQMEILANQLTGLMDMKIFYKGKNTGSNACVPR--PCSLLCLPKANNSRSCRCPEDV 1046
+G L + + + + G++ C+ + C +C K + C C E
Sbjct: 713 RTGKDRVRLQGSMLKPSSLVVVHPLAKPGADPCLYQNGGCEHIC-KKRLGTAWCSCREGF 771
Query: 1047 SSSVLPSGDLMCDCPQGYQLKNNTCVKEENTC----LRNQYRCSNGNCINSIWWCDFDND 1102
+ S C G+QL V +N + ++ R S N S +
Sbjct: 772 MKA---SDGKTCLALDGHQLLAGGEVDLKNQVTPLDILSKTRVSEDNITESQHMLVAEI- 827
Query: 1103 CGDMSDERNCPTTICDLDTQFRC---QESGTCIPLSYKCDLEDDCGDN---SDESHCEM- 1155
+SD+ +C C + RC E TC +C L+ GD SD CEM
Sbjct: 828 --MVSDQDDCAPVGCSM--YARCISEGEDATC-----QC-LKGFAGDGKLCSDIDECEMG 877
Query: 1156 ----HQCRSDEYNCSSGMCIRSSWVCDGDN-DCRDWSDEANCTAIYHTCEASNFQCRN 1208
S N G R S GD C D + C H+C N C N
Sbjct: 878 VPVCPPASSKCINTEGGYVCRCSEGYQGDGIHCLDIDE---CQLGEHSC-GENASCTN 931
Score = 93.2 bits (230), Expect = 3e-18
Identities = 109/463 (23%), Positives = 192/463 (41%), Gaps = 59/463 (12%)
Query: 760 FILYAVRKSIYRYDLASGATEQLPLTGLRAAVALDFDYEHNCLYWSDLALDVIQRLCLNG 819
F++++ SI+R D EQL + +V +DF Y +YW DL ++QR+ LNG
Sbjct: 47 FLIFSHGNSIFRIDTEGTNYEQL-VVDAGVSVIMDFHYNEKRIYWVDLERQLLQRVFLNG 105
Query: 820 STGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANPDGDFRLTIVNSSVLDRPR 879
S QE + N + V +A +++ + W + I V + G+ ++ S L P
Sbjct: 106 SR-QERVCNIE-KNVSGMAINWINEEVIWSNQQEGIITVTDMKGNNSHILL--SALKYPA 161
Query: 880 ALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVKWPNGISVD--DQWIYWTD 937
+ + P E +FW+ ++ +YR+++DG L+ K +S+D D+ ++W
Sbjct: 162 NVAVDPVERFIFWS--SEVAGSLYRADLDGVGVKALLETSEK-ITAVSLDVLDKRLFWIQ 218
Query: 938 AYLECIERITFSGQQRSVILDNLPHP-----YAIAVFKNEIYWDDWSQLSIFRASKYSGS 992
E + S + HP +A+++F + I++ W +I+ A+K++G
Sbjct: 219 YNREGSNSLICSCDYDGGSVHISKHPTQHNLFAMSLFGDRIFYSTWKMKTIWIANKHTGK 278
Query: 993 QME--ILANQLTGLMDMKIFYKGKNTGSNACVPRPCSLLCLPKANNSRSCRCPEDVSSSV 1050
M L + L ++K+ + + P LC + N S C +D+ S
Sbjct: 279 DMVRINLHSSFVPLGELKVVHPLAQPKAEDDTWEPEQKLCKLRKGNCSSTVCGQDLQSH- 337
Query: 1051 LPSGDLMCDCPQGYQL-KNNTCVKEENTCLRNQYRCSNGNCINS--IWWCDFDNDCGDMS 1107
+C C +GY L ++ ++ N C + C+ G C N+ ++C
Sbjct: 338 ------LCMCAEGYALSRDRKYCEDVNECAFWNHGCTLG-CKNTPGSYYC---------- 380
Query: 1108 DERNCPTTICDLDTQFRCQESGTC----IPLSYKCDLEDD-----CGDNS----DESHCE 1154
CP L RC + +C S+ C L + C + S D C
Sbjct: 381 ---TCPVGFVLLPDGKRCHQLVSCPRNVSECSHDCVLTSEGPLCFCPEGSVLERDGKTCS 437
Query: 1155 MHQCRSDEYNCSSGMCI---RSSWVCDGDNDCRDWSDEANCTA 1194
C S + S +C+ SW CD DE +C A
Sbjct: 438 --GCSSPDNGGCSQLCVPLSPVSWECDCFPGYDLQLDEKSCAA 478
>gi|32698824 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 122 bits (306), Expect = 4e-27
Identities = 73/221 (33%), Positives = 120/221 (54%), Gaps = 7/221 (3%)
Query: 802 LYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANP 861
+YW+D + I+R L+GS G + +IN+ + + +A +++ LYW G + IEV
Sbjct: 5 VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
Query: 862 DGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVK 921
+ +V+ +D PRA+ L P+ G+ +W DWG+ P I R+N+D LV+ +
Sbjct: 64 NSTSHKILVSED-MDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVNASLG 121
Query: 922 WPNGISVDDQ--WIYWTDAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDW 978
WPNG+++D Q +YW DA + IE I+ +R +L D LPH + + + IYW W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
Query: 979 SQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSN 1019
SI R K ++ +++ +QL LM +K K G+N
Sbjct: 182 QHHSIKRVHKVKANR-DVIIDQLPDLMGLKAVNVDKVVGTN 221
>gi|209447022 low density lipoprotein receptor-related protein 5-like
[Homo sapiens]
Length = 252
Score = 122 bits (306), Expect = 4e-27
Identities = 73/221 (33%), Positives = 120/221 (54%), Gaps = 7/221 (3%)
Query: 802 LYWSDLALDVIQRLCLNGSTGQEVIINSGLETVEALAFEPLSQLLYWVDAGFKKIEVANP 861
+YW+D + I+R L+GS G + +IN+ + + +A +++ LYW G + IEV
Sbjct: 5 VYWTDDEVWAIRRAYLDGS-GAQTLINTKINDPDDIAVNWVARSLYWTHTGTEHIEVTCL 63
Query: 862 DGDFRLTIVNSSVLDRPRALVLVPQEGVMFWTDWGDLKPGIYRSNMDGSAAYHLVSEDVK 921
+ +V+ +D PRA+ L P+ G+ +W DWG+ P I R+N+D LV+ +
Sbjct: 64 NSTSHKILVSED-MDEPRAIALHPEMGLTYWIDWGE-NPEIKRANLDRQELRVLVNASLG 121
Query: 922 WPNGISVDDQ--WIYWTDAYLECIERITFSGQQRSVIL-DNLPHPYAIAVFKNEIYWDDW 978
WPNG+++D Q +YW DA + IE I+ +R +L D LPH + + + IYW W
Sbjct: 122 WPNGLALDLQEGKLYWGDAKTDKIEAISVDETKRQTLLKDKLPHIFRFTLLGDFIYWTAW 181
Query: 979 SQLSIFRASKYSGSQMEILANQLTGLMDMKIFYKGKNTGSN 1019
SI R K ++ +++ +QL LM +K K G+N
Sbjct: 182 QHHSIKRVHKVKANR-DVIIDQLPDLMGLKAVNVDKVVGTN 221
>gi|167555125 low density lipoprotein receptor-related protein 3 [Homo
sapiens]
Length = 770
Score = 121 bits (304), Expect = 7e-27
Identities = 100/366 (27%), Positives = 137/366 (37%), Gaps = 55/366 (15%)
Query: 1198 TCEASNFQCRNGHCIPQRWACDGDTDCQDGSDEDPVNCEKKCN---GFRCPNGT------ 1248
+C+A F+C NG C+P W C+ +C DGSDE NC + G CP GT
Sbjct: 165 SCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEG--NCSAPASEPPGSLCPGGTFPCSGA 222
Query: 1249 ----CIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQQCLFHSMVCDGII-QCR 1303
C+P + CDGL+DC DGSDE C D C R + S + R
Sbjct: 223 RSTRCLPVERRCDGLQDCGDGSDEAGCP-------DLACGRRLGSFYGSFASPDLFGAAR 275
Query: 1304 DGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDDCGDYSDEANCENPT 1363
SD + +QD + E + V + +G+ + GD +
Sbjct: 276 GPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQV-----YEGLGERGDRLLQTLSYRSN 330
Query: 1364 EAPNCSRYFQFRCENGHCIPNRWKCDRENDCGDWSDEKDCGDSHILPFSTPGPSTCLPNY 1423
P Q R + R G + + LP+ P S+ +
Sbjct: 331 HRPVSLEAAQGRLTVAYHA-------RARSAGHGFNATYQVKGYCLPWEQPCGSSSDSDG 383
Query: 1424 YRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRFEFECHQPKT 1483
C + CDG+ CA G DE+ CP + P C+ C+ P
Sbjct: 384 GSLGDQGCFSEPQRCDGWWHCASGRDEQGCP--------ACPPDQYPCEGGSGLCYTPA- 434
Query: 1484 CIPNWKRCDGHQDCQDGRDEANCPTHSTLTCMSREFQCEDGEACIVLSERCDGFLDCSDE 1543
RC+ + C DG DE NC +C F C CI + RCDG DC D
Sbjct: 435 -----DRCNNQKSCPDGADEKNC-----FSCQPGTFHC-GTNLCIFETWRCDGQEDCQDG 483
Query: 1544 SDEKAC 1549
SDE C
Sbjct: 484 SDEHGC 489
Score = 113 bits (283), Expect = 2e-24
Identities = 96/370 (25%), Positives = 136/370 (36%), Gaps = 102/370 (27%)
Query: 1062 QGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC-------PT 1114
QG++L + +C +++RC NG C+ W C+ ++CGD SDE NC P
Sbjct: 150 QGFRLSYIRGKLGQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNCSAPASEPPG 209
Query: 1115 TICDLDTQFRCQ--ESGTCIPLSYKCDLEDDCGDNSDESHCEMHQC------------RS 1160
++C T F C S C+P+ +CD DCGD SDE+ C C
Sbjct: 210 SLCPGGT-FPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCPDLACGRRLGSFYGSFASP 268
Query: 1161 DEYNCSSGMC-IRSSWVCD------------------------------GDNDCRDWSDE 1189
D + + G + +W+ D GD + S
Sbjct: 269 DLFGAARGPSDLHCTWLVDTQDSRRVLLQLELRLGYDDYVQVYEGLGERGDRLLQTLSYR 328
Query: 1190 AN------------CTAIYHTCEAS-------NFQCRNGHCIPQRWACDGDTDCQDGSDE 1230
+N T YH S +Q + G+C+P C +D GS
Sbjct: 329 SNHRPVSLEAAQGRLTVAYHARARSAGHGFNATYQVK-GYCLPWEQPCGSSSDSDGGSLG 387
Query: 1231 DPVNCEKKCNGFRCPNGTCIPSSKHCDGLRDCSDGSDEQHCEPLCTHFMDFVCKNRQ-QC 1289
D C + CDG C+ G DEQ C P C + C+ C
Sbjct: 388 DQ---------------GCFSEPQRCDGWWHCASGRDEQGC-PACPP-DQYPCEGGSGLC 430
Query: 1290 LFHSMVCDGIIQCRDGSDEDAAFAGCSQDPEFHKVCDEFGFQCQNGVCISLIWKCDGMDD 1349
+ C+ C DG+DE F+ C F C +CI W+CDG +D
Sbjct: 431 YTPADRCNNQKSCPDGADEKNCFS-----------CQPGTFHCGTNLCIFETWRCDGQED 479
Query: 1350 CGDYSDEANC 1359
C D SDE C
Sbjct: 480 CQDGSDEHGC 489
Score = 74.7 bits (182), Expect = 9e-13
Identities = 37/95 (38%), Positives = 51/95 (53%), Gaps = 8/95 (8%)
Query: 1415 GPSTCLPNYYRCSSGTCVMDTWVCDGYRDCADGSDEEACPLLANVTAASTPTQLGRCDRF 1474
G ++C + +RC +G C+ W C+ +C DGSDE C + A+ P L C
Sbjct: 162 GQASCQADEFRCDNGKCLPGPWQCNTVDECGDGSDEGNC----SAPASEPPGSL--CPGG 215
Query: 1475 EFECHQPKT--CIPNWKRCDGHQDCQDGRDEANCP 1507
F C ++ C+P +RCDG QDC DG DEA CP
Sbjct: 216 TFPCSGARSTRCLPVERRCDGLQDCGDGSDEAGCP 250
Score = 73.6 bits (179), Expect = 2e-12
Identities = 39/118 (33%), Positives = 55/118 (46%), Gaps = 18/118 (15%)
Query: 1078 CLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNCPTTICDLDTQFRCQE-SGTCIPLSY 1136
C RC WW C DE+ CP C D Q+ C+ SG C +
Sbjct: 391 CFSEPQRCDG-------WW-----HCASGRDEQGCPA--CPPD-QYPCEGGSGLCYTPAD 435
Query: 1137 KCDLEDDCGDNSDESHCEMHQCRSDEYNCSSGMCIRSSWVCDGDNDCRDWSDEANCTA 1194
+C+ + C D +DE +C C+ ++C + +CI +W CDG DC+D SDE C A
Sbjct: 436 RCNNQKSCPDGADEKNC--FSCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGCLA 491
Score = 60.5 bits (145), Expect = 2e-08
Identities = 31/87 (35%), Positives = 40/87 (45%), Gaps = 7/87 (8%)
Query: 1471 CDRFEFECHQPKTCIPNWKRCDGHQDCQDGRDEANCPTHST----LTCMSREFQCEDGEA 1526
C EF C K C+P +C+ +C DG DE NC ++ C F C +
Sbjct: 166 CQADEFRCDNGK-CLPGPWQCNTVDECGDGSDEGNCSAPASEPPGSLCPGGTFPCSGARS 224
Query: 1527 --CIVLSERCDGFLDCSDESDEKACSD 1551
C+ + RCDG DC D SDE C D
Sbjct: 225 TRCLPVERRCDGLQDCGDGSDEAGCPD 251
Score = 39.7 bits (91), Expect = 0.033
Identities = 20/53 (37%), Positives = 22/53 (41%), Gaps = 6/53 (11%)
Query: 1060 CPQGYQLKNNTCVKEENTCLRNQYRCSNGNCINSIWWCDFDNDCGDMSDERNC 1112
CP G KN C +C + C CI W CD DC D SDE C
Sbjct: 443 CPDGADEKN--CF----SCQPGTFHCGTNLCIFETWRCDGQEDCQDGSDEHGC 489
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.135 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 93,129,084
Number of Sequences: 37866
Number of extensions: 4587839
Number of successful extensions: 15302
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 99
Number of HSP's successfully gapped in prelim test: 275
Number of HSP's that attempted gapping in prelim test: 9362
Number of HSP's gapped (non-prelim): 2752
length of query: 2214
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2096
effective length of database: 13,779,330
effective search space: 28881475680
effective search space used: 28881475680
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.