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Search of human proteins with 4506399
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506399 RAE1 (RNA export 1, S.pombe) homolog [Homo sapiens]
(368 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506399 RAE1 (RNA export 1, S.pombe) homolog [Homo sapiens] 778 0.0
gi|62739173 RAE1 (RNA export 1, S.pombe) homolog [Homo sapiens] 778 0.0
gi|56550081 budding uninhibited by benzimidazoles 3 isoform b [H... 193 2e-49
gi|4757880 budding uninhibited by benzimidazoles 3 isoform a [Ho... 193 2e-49
gi|113865883 WD repeat domain 38 [Homo sapiens] 64 3e-10
gi|16554629 WD repeat domain 5 [Homo sapiens] 63 5e-10
gi|16554627 WD repeat domain 5 [Homo sapiens] 63 5e-10
gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens] 62 1e-09
gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens] 62 1e-09
gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens] 62 1e-09
gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens] 58 2e-08
gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens] 58 2e-08
gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens] 57 3e-08
gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens] 57 3e-08
gi|83779014 katanin p80 subunit B 1 [Homo sapiens] 56 4e-08
gi|23199987 WD repeat domain 5B [Homo sapiens] 56 4e-08
gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo ... 55 8e-08
gi|26665869 WD repeat domain 51B [Homo sapiens] 55 8e-08
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 55 1e-07
gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens] 55 1e-07
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 54 2e-07
gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens] 54 3e-07
gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens] 54 3e-07
gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo s... 52 8e-07
gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens] 52 1e-06
gi|21071067 TBP-associated factor 5 [Homo sapiens] 51 2e-06
gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo sapi... 51 2e-06
gi|20357529 guanine nucleotide-binding protein, beta-2 subunit [... 50 2e-06
gi|32189425 WD repeat domain 69 [Homo sapiens] 50 4e-06
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 49 5e-06
>gi|4506399 RAE1 (RNA export 1, S.pombe) homolog [Homo sapiens]
Length = 368
Score = 778 bits (2010), Expect = 0.0
Identities = 368/368 (100%), Positives = 368/368 (100%)
Query: 1 MSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAG 60
MSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAG
Sbjct: 1 MSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAG 60
Query: 61 SWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQA 120
SWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQA
Sbjct: 61 SWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQA 120
Query: 121 IQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIY 180
IQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIY
Sbjct: 121 IQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIY 180
Query: 181 PMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRV 240
PMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRV
Sbjct: 181 PMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRV 240
Query: 241 AIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFW 300
AIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFW
Sbjct: 241 AIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFW 300
Query: 301 DKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAE 360
DKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAE
Sbjct: 301 DKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAE 360
Query: 361 ELKPRNKK 368
ELKPRNKK
Sbjct: 361 ELKPRNKK 368
>gi|62739173 RAE1 (RNA export 1, S.pombe) homolog [Homo sapiens]
Length = 368
Score = 778 bits (2010), Expect = 0.0
Identities = 368/368 (100%), Positives = 368/368 (100%)
Query: 1 MSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAG 60
MSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAG
Sbjct: 1 MSLFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAG 60
Query: 61 SWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQA 120
SWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQA
Sbjct: 61 SWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQA 120
Query: 121 IQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIY 180
IQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIY
Sbjct: 121 IQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIY 180
Query: 181 PMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRV 240
PMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRV
Sbjct: 181 PMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRV 240
Query: 241 AIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFW 300
AIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFW
Sbjct: 241 AIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFW 300
Query: 301 DKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAE 360
DKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAE
Sbjct: 301 DKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAE 360
Query: 361 ELKPRNKK 368
ELKPRNKK
Sbjct: 361 ELKPRNKK 368
>gi|56550081 budding uninhibited by benzimidazoles 3 isoform b [Homo
sapiens]
Length = 326
Score = 193 bits (490), Expect = 2e-49
Identities = 116/338 (34%), Positives = 177/338 (52%), Gaps = 20/338 (5%)
Query: 31 DIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVL 90
+ ++ P+D I + FSP T FL+ SW VR ++V + + + HTG VL
Sbjct: 6 EFKLNQPPEDGISSVKFSPNT--SQFLLVSSWDTSVRLYDVPANSMRL---KYQHTGAVL 60
Query: 91 DVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWD 150
D C D + ++ D KM DL+++Q + HDAP++ + + P + ++TGSWD
Sbjct: 61 D-CAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEY--CPEVNVMVTGSWD 117
Query: 151 KTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESP 210
+T+K WD R+ PE+ Y V +V TA R ++V+ L N +R ES
Sbjct: 118 QTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESS 177
Query: 211 LKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINP-PNPAKDNFTFKCHRSNGTNTSA 269
LK+Q RC+ F +KQ G+ L SIEGRVA+ Y++P P K + FKCHR N
Sbjct: 178 LKYQTRCIRAFPNKQ----GYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNI-- 231
Query: 270 PQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNI 329
+ IY VN I+FH +H T AT GSDG + WD + +L + I++ F+++G
Sbjct: 232 -EQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTT 290
Query: 330 FAYASSYDWSKGHEFYNPQKKNYIFLRNAAE-ELKPRN 366
A ASSY + ++ IF+R + E KP++
Sbjct: 291 LAIASSYMYEMDD---TEHPEDGIFIRQVTDAETKPKS 325
>gi|4757880 budding uninhibited by benzimidazoles 3 isoform a [Homo
sapiens]
Length = 328
Score = 193 bits (490), Expect = 2e-49
Identities = 116/338 (34%), Positives = 177/338 (52%), Gaps = 20/338 (5%)
Query: 31 DIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVL 90
+ ++ P+D I + FSP T FL+ SW VR ++V + + + HTG VL
Sbjct: 6 EFKLNQPPEDGISSVKFSPNT--SQFLLVSSWDTSVRLYDVPANSMRL---KYQHTGAVL 60
Query: 91 DVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWD 150
D C D + ++ D KM DL+++Q + HDAP++ + + P + ++TGSWD
Sbjct: 61 D-CAFYDPTHAWSGGLDHQLKMHDLNTDQENLVGTHDAPIRCVEY--CPEVNVMVTGSWD 117
Query: 151 KTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESP 210
+T+K WD R+ PE+ Y V +V TA R ++V+ L N +R ES
Sbjct: 118 QTVKLWDPRTPCNAGTFSQPEKVYTLSVSGDRLIVGTAGRRVLVWDLRNMGYVQQRRESS 177
Query: 211 LKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINP-PNPAKDNFTFKCHRSNGTNTSA 269
LK+Q RC+ F +KQ G+ L SIEGRVA+ Y++P P K + FKCHR N
Sbjct: 178 LKYQTRCIRAFPNKQ----GYVLSSIEGRVAVEYLDPSPEVQKKKYAFKCHRLKENNI-- 231
Query: 270 PQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNI 329
+ IY VN I+FH +H T AT GSDG + WD + +L + I++ F+++G
Sbjct: 232 -EQIYPVNAISFHNIHNTFATGGSDGFVNIWDPFNKKRLCQFHRYPTSIASLAFSNDGTT 290
Query: 330 FAYASSYDWSKGHEFYNPQKKNYIFLRNAAE-ELKPRN 366
A ASSY + ++ IF+R + E KP++
Sbjct: 291 LAIASSYMYEMDD---TEHPEDGIFIRQVTDAETKPKS 325
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 63.5 bits (153), Expect = 3e-10
Identities = 40/123 (32%), Positives = 67/123 (54%), Gaps = 8/123 (6%)
Query: 46 SFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTAS 105
+FSP G L+ GS V WE + SGQ + + HTGPV +S DG +AS
Sbjct: 28 AFSPD---GQMLLTGSEDGCVYGWETR-SGQLLWRLGG-HTGPVKFCRFSPDGHLFASAS 82
Query: 106 CDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPM 164
CD T ++WD++ + +++ + H V+T+ + +P+ + +G WDK + WD +S +
Sbjct: 83 CDCTVRLWDVARAKCLRVLKGHQRSVETVSF--SPDSRQLASGGWDKRVMLWDVQSGQML 140
Query: 165 MVL 167
+L
Sbjct: 141 RLL 143
Score = 48.1 bits (113), Expect = 1e-05
Identities = 40/145 (27%), Positives = 68/145 (46%), Gaps = 16/145 (11%)
Query: 30 KDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPV 89
K + V S+ +SFSP + L +G W V W+VQ SGQ + + H +
Sbjct: 96 KCLRVLKGHQRSVETVSFSPDSRQ---LASGGWDKRVMLWDVQ-SGQML-RLLVGHRDSI 150
Query: 90 LDVCWSDDGSKVFTASCDKTAKMWDLS------SNQAIQIAQHDAPVKTIHWIKAPNYSC 143
+S + + T S D T +WDL S+QA++ H A + + + +
Sbjct: 151 QSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALE--GHSANISCLCYSAS---GL 205
Query: 144 VMTGSWDKTLKFWDTRSSNPMMVLQ 168
+ +GSWDKT+ W +S+ ++ L+
Sbjct: 206 LASGSWDKTIHIWKPTTSSLLIQLK 230
Score = 40.0 bits (92), Expect = 0.003
Identities = 62/276 (22%), Positives = 95/276 (34%), Gaps = 37/276 (13%)
Query: 85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSC 143
H G V +S DG + T S D W+ S Q + ++ H PVK + +P+
Sbjct: 20 HGGEVNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRF--SPDGHL 77
Query: 144 VMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYP-MAVVATAERGLIVYQLENQPS 202
+ S D T++ WD + + VL+ +R P +A+ V + Q
Sbjct: 78 FASASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSG 137
Query: 203 EFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPA---------KD 253
+ R L HR D A GS + V I + PA
Sbjct: 138 QMLR----LLVGHRDSIQSSDFSPTVNCLATGSWDSTVHIWDLRMVTPAVSHQALEGHSA 193
Query: 254 NFTFKCHRSNGTNTSAPQD--------------------IYAVNGIAFHPVHGTLATVGS 293
N + C+ ++G S D + V IAF P LA+ G
Sbjct: 194 NISCLCYSASGLLASGSWDKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGY 253
Query: 294 DGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNI 329
WD + L+T + + C F +G I
Sbjct: 254 SRMVKVWDCNTGKCLETLKGVLDVAHTCAFTPDGKI 289
Score = 28.9 bits (63), Expect = 7.7
Identities = 19/59 (32%), Positives = 26/59 (44%)
Query: 276 VNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYAS 334
VN AF P L T DG W+ + L P+ C F+ +G++FA AS
Sbjct: 24 VNSSAFSPDGQMLLTGSEDGCVYGWETRSGQLLWRLGGHTGPVKFCRFSPDGHLFASAS 82
>gi|16554629 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 62.8 bits (151), Expect = 5e-10
Identities = 37/130 (28%), Positives = 71/130 (54%), Gaps = 9/130 (6%)
Query: 30 KDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPV 89
K ++ + + C +F+P + N +++GS+ VR W+V+ +G+ + K H+ PV
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQS---NLIVSGSFDESVRIWDVK-TGKCL-KTLPAHSDPV 174
Query: 90 LDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ--IAQHDAPVKTIHWIKAPNYSCVMTG 147
V ++ DGS + ++S D ++WD +S Q ++ I + PV + + +PN ++
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF--SPNGKYILAA 232
Query: 148 SWDKTLKFWD 157
+ D TLK WD
Sbjct: 233 TLDNTLKLWD 242
Score = 55.5 bits (132), Expect = 8e-08
Identities = 34/128 (26%), Positives = 65/128 (50%), Gaps = 8/128 (6%)
Query: 41 SIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSK 100
++ + FSP G +L + S ++ W D K H + DV WS D +
Sbjct: 47 AVSSVKFSPN---GEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSNL 101
Query: 101 VFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTR 159
+ +AS DKT K+WD+SS + ++ + H V ++ P + +++GS+D++++ WD +
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF--NPQSNLIVSGSFDESVRIWDVK 159
Query: 160 SSNPMMVL 167
+ + L
Sbjct: 160 TGKCLKTL 167
Score = 42.0 bits (97), Expect = 9e-04
Identities = 38/167 (22%), Positives = 68/167 (40%), Gaps = 27/167 (16%)
Query: 25 NHNPMKDIEVTSSPDDSIG--------CLSFSPP----------TLPGNFLIAGSWANDV 66
N NP ++ V+ S D+S+ CL P G+ +++ S+
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 67 RCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQH 126
R W+ SGQ + PV V +S +G + A+ D T K+WD S + ++
Sbjct: 196 RIWDTA-SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 127 DAPVKTIHWIKAPNYSC-----VMTGSWDKTLKFWDTRSSNPMMVLQ 168
K + N+S +++GS D + W+ ++ + LQ
Sbjct: 255 H---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/85 (29%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Query: 85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSC 143
HT V V +S +G + ++S DK K+W + + I+ H + + W N
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN--L 101
Query: 144 VMTGSWDKTLKFWDTRSSNPMMVLQ 168
+++ S DKTLK WD S + L+
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLK 126
Score = 31.6 bits (70), Expect = 1.2
Identities = 18/57 (31%), Positives = 26/57 (45%), Gaps = 1/57 (1%)
Query: 281 FHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYD 337
F+P + + D WD LKT P+SA FN +G++ +SSYD
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV-SSSYD 192
>gi|16554627 WD repeat domain 5 [Homo sapiens]
Length = 334
Score = 62.8 bits (151), Expect = 5e-10
Identities = 37/130 (28%), Positives = 71/130 (54%), Gaps = 9/130 (6%)
Query: 30 KDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPV 89
K ++ + + C +F+P + N +++GS+ VR W+V+ +G+ + K H+ PV
Sbjct: 120 KCLKTLKGHSNYVFCCNFNPQS---NLIVSGSFDESVRIWDVK-TGKCL-KTLPAHSDPV 174
Query: 90 LDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ--IAQHDAPVKTIHWIKAPNYSCVMTG 147
V ++ DGS + ++S D ++WD +S Q ++ I + PV + + +PN ++
Sbjct: 175 SAVHFNRDGSLIVSSSYDGLCRIWDTASGQCLKTLIDDDNPPVSFVKF--SPNGKYILAA 232
Query: 148 SWDKTLKFWD 157
+ D TLK WD
Sbjct: 233 TLDNTLKLWD 242
Score = 55.5 bits (132), Expect = 8e-08
Identities = 34/128 (26%), Positives = 65/128 (50%), Gaps = 8/128 (6%)
Query: 41 SIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSK 100
++ + FSP G +L + S ++ W D K H + DV WS D +
Sbjct: 47 AVSSVKFSPN---GEWLASSSADKLIKIWGAYDG--KFEKTISGHKLGISDVAWSSDSNL 101
Query: 101 VFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTR 159
+ +AS DKT K+WD+SS + ++ + H V ++ P + +++GS+D++++ WD +
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLKGHSNYVFCCNF--NPQSNLIVSGSFDESVRIWDVK 159
Query: 160 SSNPMMVL 167
+ + L
Sbjct: 160 TGKCLKTL 167
Score = 42.0 bits (97), Expect = 9e-04
Identities = 38/167 (22%), Positives = 68/167 (40%), Gaps = 27/167 (16%)
Query: 25 NHNPMKDIEVTSSPDDSIG--------CLSFSPP----------TLPGNFLIAGSWANDV 66
N NP ++ V+ S D+S+ CL P G+ +++ S+
Sbjct: 136 NFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIVSSSYDGLC 195
Query: 67 RCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQH 126
R W+ SGQ + PV V +S +G + A+ D T K+WD S + ++
Sbjct: 196 RIWDTA-SGQCLKTLIDDDNPPVSFVKFSPNGKYILAATLDNTLKLWDYSKGKCLKTYTG 254
Query: 127 DAPVKTIHWIKAPNYSC-----VMTGSWDKTLKFWDTRSSNPMMVLQ 168
K + N+S +++GS D + W+ ++ + LQ
Sbjct: 255 H---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQ 298
Score = 40.0 bits (92), Expect = 0.003
Identities = 25/85 (29%), Positives = 41/85 (48%), Gaps = 3/85 (3%)
Query: 85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSC 143
HT V V +S +G + ++S DK K+W + + I+ H + + W N
Sbjct: 44 HTKAVSSVKFSPNGEWLASSSADKLIKIWGAYDGKFEKTISGHKLGISDVAWSSDSN--L 101
Query: 144 VMTGSWDKTLKFWDTRSSNPMMVLQ 168
+++ S DKTLK WD S + L+
Sbjct: 102 LVSASDDKTLKIWDVSSGKCLKTLK 126
Score = 31.6 bits (70), Expect = 1.2
Identities = 18/57 (31%), Positives = 26/57 (45%), Gaps = 1/57 (1%)
Query: 281 FHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASSYD 337
F+P + + D WD LKT P+SA FN +G++ +SSYD
Sbjct: 137 FNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDPVSAVHFNRDGSLIV-SSSYD 192
>gi|239787764 WD repeat domain 51A isoform 3 [Homo sapiens]
Length = 369
Score = 61.6 bits (148), Expect = 1e-09
Identities = 40/126 (31%), Positives = 63/126 (50%), Gaps = 16/126 (12%)
Query: 40 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 99
D++ C++FSP G+ L +GS VR W G++ + HT V V + DG
Sbjct: 24 DAVTCVNFSPS---GHLLASGSRDKTVRIWVPNVKGEST--VFRAHTATVRSVHFCSDGQ 78
Query: 100 KVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYS----CVMTGSWDKTLK 154
TAS DKT K+W + + ++QH I+W++ +S +++ S DKT+K
Sbjct: 79 SFVTASDDKTVKVWATHRQKFLFSLSQH------INWVRCAKFSPDGRLIVSASDDKTVK 132
Query: 155 FWDTRS 160
WD S
Sbjct: 133 LWDKSS 138
Score = 46.2 bits (108), Expect = 5e-05
Identities = 34/117 (29%), Positives = 56/117 (47%), Gaps = 8/117 (6%)
Query: 42 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKV 101
+ C FSP G +++ S V+ W+ S + + H G V V + G+ +
Sbjct: 110 VRCAKFSPD---GRLIVSASDDKTVKLWD--KSSRECVHSYCEHGGFVTYVDFHPSGTCI 164
Query: 102 FTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 157
A D T K+WD+ +++ +Q Q H A V + + + NY ++T S D TLK D
Sbjct: 165 AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY--LITASSDSTLKILD 219
Score = 41.6 bits (96), Expect = 0.001
Identities = 55/253 (21%), Positives = 89/253 (35%), Gaps = 23/253 (9%)
Query: 85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLS-SNQAIQIAQHDAPVKTIHWIKAPNYSC 143
H V V +S G + + S DKT ++W + ++ H A V+++H+ +
Sbjct: 22 HKDAVTCVNFSPSGHLLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF--CSDGQS 79
Query: 144 VMTGSWDKTLKFWDTRSSNPMMVL-QLPERCYCADVIYPMAVVATAERGLIVYQLENQPS 202
+T S DKT+K W T + L Q CA ++ +A V +
Sbjct: 80 FVTASDDKTVKVWATHRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSR 139
Query: 203 EFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRS 262
E +H + D T A ++ V + + + ++ H +
Sbjct: 140 ECVHSYC----EHGGFVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH---YQLHSA 192
Query: 263 NGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACC 322
AVNG++FHP L T SD D L T P +
Sbjct: 193 ------------AVNGLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVA 240
Query: 323 FNHNGNIFAYASS 335
F+ G FA S
Sbjct: 241 FSRTGEYFASGGS 253
Score = 39.3 bits (90), Expect = 0.006
Identities = 34/157 (21%), Positives = 63/157 (40%), Gaps = 12/157 (7%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G + A N V+ W+V+ + + Q+H+ V + + G+ + TAS D T K+
Sbjct: 161 GTCIAAAGMDNTVKVWDVRT--HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKIL 218
Query: 114 DLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPER 172
DL + + + H P T+ + + Y +G D+ + W + + +
Sbjct: 219 DLMEGRLLYTLHGHQGPATTVAFSRTGEY--FASGGSDEQVMVWKSN-------FDIVDH 269
Query: 173 CYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIES 209
V P A +A++ L P R +ES
Sbjct: 270 GEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVES 306
>gi|239787760 WD repeat domain 51A isoform 2 [Homo sapiens]
Length = 359
Score = 61.6 bits (148), Expect = 1e-09
Identities = 40/126 (31%), Positives = 63/126 (50%), Gaps = 16/126 (12%)
Query: 40 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 99
D++ C++FSP G+ L +GS VR W G++ + HT V V + DG
Sbjct: 62 DAVTCVNFSPS---GHLLASGSRDKTVRIWVPNVKGEST--VFRAHTATVRSVHFCSDGQ 116
Query: 100 KVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYS----CVMTGSWDKTLK 154
TAS DKT K+W + + ++QH I+W++ +S +++ S DKT+K
Sbjct: 117 SFVTASDDKTVKVWATHRQKFLFSLSQH------INWVRCAKFSPDGRLIVSASDDKTVK 170
Query: 155 FWDTRS 160
WD S
Sbjct: 171 LWDKSS 176
Score = 46.2 bits (108), Expect = 5e-05
Identities = 34/117 (29%), Positives = 56/117 (47%), Gaps = 8/117 (6%)
Query: 42 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKV 101
+ C FSP G +++ S V+ W+ S + + H G V V + G+ +
Sbjct: 148 VRCAKFSPD---GRLIVSASDDKTVKLWD--KSSRECVHSYCEHGGFVTYVDFHPSGTCI 202
Query: 102 FTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 157
A D T K+WD+ +++ +Q Q H A V + + + NY ++T S D TLK D
Sbjct: 203 AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY--LITASSDSTLKILD 257
Score = 45.8 bits (107), Expect = 6e-05
Identities = 64/298 (21%), Positives = 107/298 (35%), Gaps = 28/298 (9%)
Query: 40 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 99
D++ C+ FS T L +GS + + W ++ + H V V +S G
Sbjct: 20 DAVTCVDFSINTKQ---LASGSMDSCLMVWHMKPQSRAYRFTG--HKDAVTCVNFSPSGH 74
Query: 100 KVFTASCDKTAKMWDLS-SNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDT 158
+ + S DKT ++W + ++ H A V+++H+ + +T S DKT+K W T
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF--CSDGQSFVTASDDKTVKVWAT 132
Query: 159 RSSNPMMVL-QLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRC 217
+ L Q CA ++ +A V + E +H
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC----EHGG 188
Query: 218 VAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVN 277
+ D T A ++ V + + + ++ H + AVN
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH---YQLHSA------------AVN 233
Query: 278 GIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
G++FHP L T SD D L T P + F+ G FA S
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Score = 38.9 bits (89), Expect = 0.007
Identities = 25/104 (24%), Positives = 47/104 (45%), Gaps = 5/104 (4%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G + A N V+ W+V+ + + Q+H+ V + + G+ + TAS D T K+
Sbjct: 199 GTCIAAAGMDNTVKVWDVRT--HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKIL 256
Query: 114 DLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFW 156
DL + + + H P T+ + + Y +G D+ + W
Sbjct: 257 DLMEGRLLYTLHGHQGPATTVAFSRTGEY--FASGGSDEQVMVW 298
>gi|239787754 WD repeat domain 51A isoform 1 [Homo sapiens]
Length = 407
Score = 61.6 bits (148), Expect = 1e-09
Identities = 40/126 (31%), Positives = 63/126 (50%), Gaps = 16/126 (12%)
Query: 40 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 99
D++ C++FSP G+ L +GS VR W G++ + HT V V + DG
Sbjct: 62 DAVTCVNFSPS---GHLLASGSRDKTVRIWVPNVKGEST--VFRAHTATVRSVHFCSDGQ 116
Query: 100 KVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYS----CVMTGSWDKTLK 154
TAS DKT K+W + + ++QH I+W++ +S +++ S DKT+K
Sbjct: 117 SFVTASDDKTVKVWATHRQKFLFSLSQH------INWVRCAKFSPDGRLIVSASDDKTVK 170
Query: 155 FWDTRS 160
WD S
Sbjct: 171 LWDKSS 176
Score = 46.2 bits (108), Expect = 5e-05
Identities = 34/117 (29%), Positives = 56/117 (47%), Gaps = 8/117 (6%)
Query: 42 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKV 101
+ C FSP G +++ S V+ W+ S + + H G V V + G+ +
Sbjct: 148 VRCAKFSPD---GRLIVSASDDKTVKLWD--KSSRECVHSYCEHGGFVTYVDFHPSGTCI 202
Query: 102 FTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 157
A D T K+WD+ +++ +Q Q H A V + + + NY ++T S D TLK D
Sbjct: 203 AAAGMDNTVKVWDVRTHRLLQHYQLHSAAVNGLSFHPSGNY--LITASSDSTLKILD 257
Score = 45.8 bits (107), Expect = 6e-05
Identities = 64/298 (21%), Positives = 107/298 (35%), Gaps = 28/298 (9%)
Query: 40 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 99
D++ C+ FS T L +GS + + W ++ + H V V +S G
Sbjct: 20 DAVTCVDFSINTKQ---LASGSMDSCLMVWHMKPQSRAYRFTG--HKDAVTCVNFSPSGH 74
Query: 100 KVFTASCDKTAKMWDLS-SNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDT 158
+ + S DKT ++W + ++ H A V+++H+ + +T S DKT+K W T
Sbjct: 75 LLASGSRDKTVRIWVPNVKGESTVFRAHTATVRSVHF--CSDGQSFVTASDDKTVKVWAT 132
Query: 159 RSSNPMMVL-QLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRC 217
+ L Q CA ++ +A V + E +H
Sbjct: 133 HRQKFLFSLSQHINWVRCAKFSPDGRLIVSASDDKTVKLWDKSSRECVHSYC----EHGG 188
Query: 218 VAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVN 277
+ D T A ++ V + + + ++ H + AVN
Sbjct: 189 FVTYVDFHPSGTCIAAAGMDNTVKVWDVRTHRLLQH---YQLHSA------------AVN 233
Query: 278 GIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNIFAYASS 335
G++FHP L T SD D L T P + F+ G FA S
Sbjct: 234 GLSFHPSGNYLITASSDSTLKILDLMEGRLLYTLHGHQGPATTVAFSRTGEYFASGGS 291
Score = 39.3 bits (90), Expect = 0.006
Identities = 34/157 (21%), Positives = 63/157 (40%), Gaps = 12/157 (7%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G + A N V+ W+V+ + + Q+H+ V + + G+ + TAS D T K+
Sbjct: 199 GTCIAAAGMDNTVKVWDVRT--HRLLQHYQLHSAAVNGLSFHPSGNYLITASSDSTLKIL 256
Query: 114 DLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPER 172
DL + + + H P T+ + + Y +G D+ + W + + +
Sbjct: 257 DLMEGRLLYTLHGHQGPATTVAFSRTGEY--FASGGSDEQVMVWKSN-------FDIVDH 307
Query: 173 CYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIES 209
V P A +A++ L P R +ES
Sbjct: 308 GEVTKVPRPPATLASSMGNLPEVDFPVPPGRGRSVES 344
>gi|55743149 WD repeat domain 17 isoform 2 [Homo sapiens]
Length = 1298
Score = 57.8 bits (138), Expect = 2e-08
Identities = 44/150 (29%), Positives = 62/150 (41%), Gaps = 23/150 (15%)
Query: 55 NFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVF-TASCDKTAKMW 113
+ + G +VR + V S K HT V V WS + + S D T ++W
Sbjct: 511 DMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIW 570
Query: 114 DLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPER 172
D + + I I H APV+ + W Y +++GSWD T+K WDTR
Sbjct: 571 DYTQDACINILNGHTAPVRGLMWNTEIPY-LLISGSWDYTIKVWDTREGT---------- 619
Query: 173 CYCADVIYPMAVVATAERGLIVYQLENQPS 202
C D +Y + G VY L PS
Sbjct: 620 --CVDTVY--------DHGADVYGLTCHPS 639
>gi|31317311 WD repeat domain 17 isoform 1 [Homo sapiens]
Length = 1322
Score = 57.8 bits (138), Expect = 2e-08
Identities = 44/150 (29%), Positives = 62/150 (41%), Gaps = 23/150 (15%)
Query: 55 NFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVF-TASCDKTAKMW 113
+ + G +VR + V S K HT V V WS + + S D T ++W
Sbjct: 535 DMIATGCEDTNVRVYYVATSSDQPLKVFSGHTAKVFHVKWSPLREGILCSGSDDGTVRIW 594
Query: 114 DLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPER 172
D + + I I H APV+ + W Y +++GSWD T+K WDTR
Sbjct: 595 DYTQDACINILNGHTAPVRGLMWNTEIPY-LLISGSWDYTIKVWDTREGT---------- 643
Query: 173 CYCADVIYPMAVVATAERGLIVYQLENQPS 202
C D +Y + G VY L PS
Sbjct: 644 --CVDTVY--------DHGADVYGLTCHPS 663
>gi|124256480 APG16 autophagy 16-like isoform 1 [Homo sapiens]
Length = 607
Score = 56.6 bits (135), Expect = 3e-08
Identities = 35/116 (30%), Positives = 58/116 (50%), Gaps = 6/116 (5%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G++L+A S R W V D + H+G VL + D +++ + S D+T K+W
Sbjct: 378 GSYLLAASNDFASRIWTVDD--YRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 435
Query: 114 DLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQL 169
DL S I+ + I + CVM+G +DK ++FWD RS + + ++L
Sbjct: 436 DLRSKVCIKTVFAGSSCNDIVCTE----QCVMSGHFDKKIRFWDIRSESIVREMEL 487
Score = 30.4 bits (67), Expect = 2.6
Identities = 19/67 (28%), Positives = 30/67 (44%), Gaps = 4/67 (5%)
Query: 47 FSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASC 106
FSP G+++ AGS + W V +G+ + H+ + V WS GS V +
Sbjct: 542 FSPD---GSYVAAGSAEGSLYIWSVL-TGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 597
Query: 107 DKTAKMW 113
A +W
Sbjct: 598 GCKAVLW 604
>gi|124256478 APG16 autophagy 16-like isoform 2 [Homo sapiens]
Length = 588
Score = 56.6 bits (135), Expect = 3e-08
Identities = 35/116 (30%), Positives = 58/116 (50%), Gaps = 6/116 (5%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G++L+A S R W V D + H+G VL + D +++ + S D+T K+W
Sbjct: 359 GSYLLAASNDFASRIWTVDD--YRLRHTLTGHSGKVLSAKFLLDNARIVSGSHDRTLKLW 416
Query: 114 DLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQL 169
DL S I+ + I + CVM+G +DK ++FWD RS + + ++L
Sbjct: 417 DLRSKVCIKTVFAGSSCNDIVCTE----QCVMSGHFDKKIRFWDIRSESIVREMEL 468
Score = 30.4 bits (67), Expect = 2.6
Identities = 19/67 (28%), Positives = 30/67 (44%), Gaps = 4/67 (5%)
Query: 47 FSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASC 106
FSP G+++ AGS + W V +G+ + H+ + V WS GS V +
Sbjct: 523 FSPD---GSYVAAGSAEGSLYIWSVL-TGKVEKVLSKQHSSSINAVAWSPSGSHVVSVDK 578
Query: 107 DKTAKMW 113
A +W
Sbjct: 579 GCKAVLW 585
>gi|83779014 katanin p80 subunit B 1 [Homo sapiens]
Length = 655
Score = 56.2 bits (134), Expect = 4e-08
Identities = 30/105 (28%), Positives = 58/105 (55%), Gaps = 5/105 (4%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G F+ +GS +++ W+++ G + H+ V + +S DG + +A+ D T K+W
Sbjct: 117 GEFVASGSQDTNIKLWDIRRKGCVF--RYRGHSQAVRCLRFSPDGKWLASAADDHTVKLW 174
Query: 114 DLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 157
DL++ + + + H PV + + PN + +GS D+T++FWD
Sbjct: 175 DLTAGKMMSEFPGHTGPVNVVEF--HPNEYLLASGSSDRTIRFWD 217
Score = 42.0 bits (97), Expect = 9e-04
Identities = 35/136 (25%), Positives = 65/136 (47%), Gaps = 21/136 (15%)
Query: 41 SIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSK 100
++ CL FSP G +L + + + V+ W++ +G+ + + HTGPV V + +
Sbjct: 149 AVRCLRFSPD---GKWLASAADDHTVKLWDLT-AGKMMSEFPG-HTGPVNVVEFHPNEYL 203
Query: 101 VFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKF-WDT 158
+ + S D+T + WDL Q + I PV+++ + P+ C+ +G D + W+
Sbjct: 204 LASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSV--LFNPDGCCLYSGCQDSLRVYGWE- 260
Query: 159 RSSNPMMVLQLPERCY 174
PERC+
Sbjct: 261 -----------PERCF 265
Score = 35.0 bits (79), Expect = 0.11
Identities = 46/236 (19%), Positives = 86/236 (36%), Gaps = 31/236 (13%)
Query: 98 GSKVFTASCDKTAKMWDLSS-NQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFW 156
G + T D +W ++ N + + H +PV+++ + P ++ GS +++ W
Sbjct: 33 GRLLATGGDDCRVNLWSINKPNCIMSLTGHTSPVESVR-LNTPE-ELIVAGSQSGSIRVW 90
Query: 157 DTRSSNPMMVLQLPERCYCADVIYP---MAVVATAERGLIVYQLENQPSEFRRIESPLKH 213
D ++ + L + C+ +P + + + ++ + + FR
Sbjct: 91 DLEAAKILRTLMGHKANICSLDFHPYGEFVASGSQDTNIKLWDIRRKGCVFRYRGH--SQ 148
Query: 214 QHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCH--RSNGTNTSAPQ 271
RC+ P G L S A D+ T K + + P
Sbjct: 149 AVRCLRF------SPDGKWLAS---------------AADDHTVKLWDLTAGKMMSEFPG 187
Query: 272 DIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNG 327
VN + FHP LA+ SD FWD + + E P+ + FN +G
Sbjct: 188 HTGPVNVVEFHPNEYLLASGSSDRTIRFWDLEKFQVVSCIEGEPGPVRSVLFNPDG 243
Score = 32.0 bits (71), Expect = 0.91
Identities = 20/76 (26%), Positives = 36/76 (47%), Gaps = 3/76 (3%)
Query: 85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSC 143
HT PV V + + S + ++WDL + + ++ + H A + ++ + P
Sbjct: 62 HTSPVESVRLNTPEELIVAGSQSGSIRVWDLEAAKILRTLMGHKANICSLDF--HPYGEF 119
Query: 144 VMTGSWDKTLKFWDTR 159
V +GS D +K WD R
Sbjct: 120 VASGSQDTNIKLWDIR 135
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 56.2 bits (134), Expect = 4e-08
Identities = 35/129 (27%), Positives = 65/129 (50%), Gaps = 8/129 (6%)
Query: 40 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 99
+++ + FSP G +L + S + W D K H + DV WS D S
Sbjct: 42 EAVSSVKFSPN---GEWLASSSADRLIIIWGAYDG--KYEKTLYGHNLEISDVAWSSDSS 96
Query: 100 KVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDT 158
++ +AS DKT K+WD+ S + ++ + H V ++ P + +++GS+D+T+K W+
Sbjct: 97 RLVSASDDKTLKLWDVRSGKCLKTLKGHSNYVFCCNF--NPPSNLIISGSFDETVKIWEV 154
Query: 159 RSSNPMMVL 167
++ + L
Sbjct: 155 KTGKCLKTL 163
Score = 45.4 bits (106), Expect = 8e-05
Identities = 34/144 (23%), Positives = 65/144 (45%), Gaps = 12/144 (8%)
Query: 30 KDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPV 89
K ++ S+ D + + F+ G+ +++GS+ R W+ SGQ + PV
Sbjct: 158 KCLKTLSAHSDPVSAVHFN---CSGSLIVSGSYDGLCRIWDAA-SGQCLKTLVDDDNPPV 213
Query: 90 LDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSC-----V 144
V +S +G + TA+ D T K+WD S + ++ K + N+S +
Sbjct: 214 SFVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGH---KNEKYCIFANFSVTGGKWI 270
Query: 145 MTGSWDKTLKFWDTRSSNPMMVLQ 168
++GS D + W+ ++ + LQ
Sbjct: 271 VSGSEDNLVYIWNLQTKEIVQKLQ 294
Score = 37.4 bits (85), Expect = 0.022
Identities = 23/85 (27%), Positives = 43/85 (50%), Gaps = 3/85 (3%)
Query: 85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSC 143
HT V V +S +G + ++S D+ +W + + + H+ + + W + + S
Sbjct: 40 HTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAW--SSDSSR 97
Query: 144 VMTGSWDKTLKFWDTRSSNPMMVLQ 168
+++ S DKTLK WD RS + L+
Sbjct: 98 LVSASDDKTLKLWDVRSGKCLKTLK 122
>gi|109948304 smu-1 suppressor of mec-8 and unc-52 homolog [Homo
sapiens]
Length = 513
Score = 55.5 bits (132), Expect = 8e-08
Identities = 58/271 (21%), Positives = 111/271 (40%), Gaps = 32/271 (11%)
Query: 39 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDG 98
DD++ C+ FS T L G+ ++ W++Q SGQ + + ++ H+ V + +S D
Sbjct: 264 DDAVLCMCFSRDT---EMLATGAQDGKIKVWKIQ-SGQCLRRFERAHSKGVTCLSFSKDS 319
Query: 99 SKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 157
S++ +AS D+T ++ L S + + + H + V + + +Y +++ S D T+K W+
Sbjct: 320 SQILSASFDQTIRIHGLKSGKTLKEFRGHSSFVNEATFTQDGHY--IISASSDGTVKIWN 377
Query: 158 TRSSNPMMVLQLPERCYCADVIYPMAVVATAERGL-IVYQLENQPSEFRRIESPLKHQHR 216
+++ C++ + A + + V L P F + ++
Sbjct: 378 MKTTE------------CSNTFKSLGSTAGTDITVNSVILLPKNPEHF-----VVCNRSN 420
Query: 217 CVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNP-----AKDNFTFKCHRSNGTNTSAPQ 271
V I + F+ G EG + P ++F C +
Sbjct: 421 TVVIMNMQGQIVRSFSSGKREGGDFVCCALSPRGEWIYCVGEDFVLYCFSTVTGKLERTL 480
Query: 272 DIYA--VNGIAFHPVHGTLATVGSDGRFSFW 300
++ V GIA HP +AT DG W
Sbjct: 481 TVHEKDVIGIAHHPHQNLIATYSEDGLLKLW 511
>gi|26665869 WD repeat domain 51B [Homo sapiens]
Length = 478
Score = 55.5 bits (132), Expect = 8e-08
Identities = 38/123 (30%), Positives = 59/123 (47%), Gaps = 14/123 (11%)
Query: 40 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 99
D + + FSP GN L + S VR W G+ + HT PV V +S DG
Sbjct: 61 DVVTSVQFSPH---GNLLASASRDRTVRLWIPDKRGKF--SEFKAHTAPVRSVDFSADGQ 115
Query: 100 KVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYS----CVMTGSWDKTLKF 155
+ TAS DK+ K+W + + + + + HW++ +S +++ S DKT+K
Sbjct: 116 FLATASEDKSIKVWSMYRQRFLY-----SLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKI 170
Query: 156 WDT 158
WDT
Sbjct: 171 WDT 173
Score = 43.9 bits (102), Expect = 2e-04
Identities = 29/107 (27%), Positives = 49/107 (45%), Gaps = 5/107 (4%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G FL S ++ W + Q + HT V +S DG + + S DKT K+W
Sbjct: 114 GQFLATASEDKSIKVWSMYR--QRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIW 171
Query: 114 DLSSNQAIQIAQHDAPVKTIHWIK-APNYSCVMTGSWDKTLKFWDTR 159
D ++ Q + V +++ P+ +C+ + D+T+K WD R
Sbjct: 172 DTTNKQCVN--NFSDSVGFANFVDFNPSGTCIASAGSDQTVKVWDVR 216
Score = 41.2 bits (95), Expect = 0.001
Identities = 32/120 (26%), Positives = 54/120 (45%), Gaps = 5/120 (4%)
Query: 40 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS 99
DS+G +F G + + V+ W+V+ + + + Q+H+G V + + G+
Sbjct: 184 DSVGFANFVDFNPSGTCIASAGSDQTVKVWDVRVN--KLLQHYQVHSGGVNCISFHPSGN 241
Query: 100 KVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDT 158
+ TAS D T K+ DL + I Q H PV T+ + K +G D + W T
Sbjct: 242 YLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGG--ELFASGGADTQVLLWRT 299
Score = 38.1 bits (87), Expect = 0.013
Identities = 62/304 (20%), Positives = 106/304 (34%), Gaps = 50/304 (16%)
Query: 41 SIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSK 100
+I L SP G L SW + W + + H V V +S G+
Sbjct: 20 AITSLDLSPN---GKQLATASWDTFLMLWNFKPHARAYRYVG--HKDVVTSVQFSPHGNL 74
Query: 101 VFTASCDKTAKMW-DLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTR 159
+ +AS D+T ++W + + H APV+++ + + + + T S DK++K W
Sbjct: 75 LASASRDRTVRLWIPDKRGKFSEFKAHTAPVRSVDF--SADGQFLATASEDKSIKVWSMY 132
Query: 160 SSNPMMVLQLPE---RCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHR 216
+ L RC + V + ++ + ++ N+ +
Sbjct: 133 RQRFLYSLYRHTHWVRCAKFSPDGRLIVSCSEDKTIKIWDTTNK---------------Q 177
Query: 217 CVAIFKDKQN-------KPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSA 269
CV F D P+G + S A + T K
Sbjct: 178 CVNNFSDSVGFANFVDFNPSGTCIAS---------------AGSDQTVKVWDVRVNKLLQ 222
Query: 270 PQDIYA--VNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNG 327
+++ VN I+FHP L T SDG D + T + P+ F+ G
Sbjct: 223 HYQVHSGGVNCISFHPSGNYLITASSDGTLKILDLLEGRLIYTLQGHTGPVFTVSFSKGG 282
Query: 328 NIFA 331
+FA
Sbjct: 283 ELFA 286
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 55.1 bits (131), Expect = 1e-07
Identities = 29/106 (27%), Positives = 50/106 (47%), Gaps = 4/106 (3%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G F ++GSW +R W++ T + HT VL V +S D ++ + S DKT K+W
Sbjct: 75 GQFALSGSWDGTLRLWDLTTG--TTTRRFVGHTKDVLSVAFSSDNRQIVSGSRDKTIKLW 132
Query: 114 DLSS--NQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 157
+ +Q H V + + + +++ WDK +K W+
Sbjct: 133 NTLGVCKYTVQDESHSEWVSCVRFSPNSSNPIIVSCGWDKLVKVWN 178
Score = 41.6 bits (96), Expect = 0.001
Identities = 30/113 (26%), Positives = 58/113 (51%), Gaps = 7/113 (6%)
Query: 50 PTLPGNFLIAGSWANDVRCWEV--QDSGQTIP-KAQQMHTGPVLDVCWSDDGSKVFTASC 106
P P + +++ S + W++ ++ IP +A + H+ V DV S DG + S
Sbjct: 25 PQFP-DMILSASRDKTIIMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFALSGSW 83
Query: 107 DKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDT 158
D T ++WDL++ + H V ++ + + + +++GS DKT+K W+T
Sbjct: 84 DGTLRLWDLTTGTTTRRFVGHTKDVLSVAF--SSDNRQIVSGSRDKTIKLWNT 134
Score = 37.0 bits (84), Expect = 0.028
Identities = 27/121 (22%), Positives = 50/121 (41%), Gaps = 6/121 (4%)
Query: 37 SPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSD 96
S + + C+ FSP + +++ W V+ W + + + HTG + V S
Sbjct: 146 SHSEWVSCVRFSPNS-SNPIIVSCGWDKLVKVWNLANC--KLKTNHIGHTGYLNTVTVSP 202
Query: 97 DGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFW 156
DGS + D A +WDL+ + + + + + + C TG ++K W
Sbjct: 203 DGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDIINALCFSPNRYWLCAATG---PSIKIW 259
Query: 157 D 157
D
Sbjct: 260 D 260
>gi|7657439 PCAF associated factor 65 beta isoform a [Homo sapiens]
Length = 589
Score = 55.1 bits (131), Expect = 1e-07
Identities = 32/121 (26%), Positives = 60/121 (49%), Gaps = 8/121 (6%)
Query: 42 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKV 101
+ C+ F P + N+L GS VR W Q + H GPVL + +S +G +
Sbjct: 429 VDCVKFHPNS---NYLATGSTDKTVRLWSAQQGNSV--RLFTGHRGPVLSLAFSPNGKYL 483
Query: 102 FTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRS 160
+A D+ K+WDL+S ++ H + ++ + +P+ + + S D +++ WD R+
Sbjct: 484 ASAGEDQRLKLWDLASGTLYKELRGHTDNITSLTF--SPDSGLIASASMDNSVRVWDIRN 541
Query: 161 S 161
+
Sbjct: 542 T 542
Score = 44.3 bits (103), Expect = 2e-04
Identities = 31/107 (28%), Positives = 51/107 (47%), Gaps = 5/107 (4%)
Query: 57 LIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLS 116
L++ S +R W++ T+ Q H PV D+ S + S D+TA++W
Sbjct: 357 LLSCSEDMSIRYWDLGSFTNTV--LYQGHAYPVWDLDISPYSLYFASGSHDRTARLWSFD 414
Query: 117 SNQAIQI-AQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSN 162
++I A H A V + + PN + + TGS DKT++ W + N
Sbjct: 415 RTYPLRIYAGHLADVDCVKF--HPNSNYLATGSTDKTVRLWSAQQGN 459
Score = 37.4 bits (85), Expect = 0.022
Identities = 30/118 (25%), Positives = 52/118 (44%), Gaps = 10/118 (8%)
Query: 45 LSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIP-KAQQMHTGPVLDVCWSDDGSKVFT 103
L SP +L + +GS R W +T P + H V V + + + + T
Sbjct: 390 LDISPYSL---YFASGSHDRTARLWSFD---RTYPLRIYAGHLADVDCVKFHPNSNYLAT 443
Query: 104 ASCDKTAKMWDLSSNQAIQI-AQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRS 160
S DKT ++W ++++ H PV ++ + +PN + + D+ LK WD S
Sbjct: 444 GSTDKTVRLWSAQQGNSVRLFTGHRGPVLSLAF--SPNGKYLASAGEDQRLKLWDLAS 499
Score = 35.8 bits (81), Expect = 0.063
Identities = 25/95 (26%), Positives = 41/95 (43%), Gaps = 3/95 (3%)
Query: 73 DSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSS-NQAIQIAQHDAPVK 131
D+ T K + H GPV + D S + + S D + + WDL S + H PV
Sbjct: 329 DNAGTEMKILRGHCGPVYSTRFLADSSGLLSCSEDMSIRYWDLGSFTNTVLYQGHAYPVW 388
Query: 132 TIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMV 166
+ +P +GS D+T + W + P+ +
Sbjct: 389 DLD--ISPYSLYFASGSHDRTARLWSFDRTYPLRI 421
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 54.3 bits (129), Expect = 2e-07
Identities = 52/219 (23%), Positives = 101/219 (46%), Gaps = 15/219 (6%)
Query: 25 NHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM 84
N+N ++ + + + D I C++ P T P F++ S ++ W+ D + + +
Sbjct: 85 NYNTLERVHMFEAHSDYIRCIAVHP-TQP--FILTSSDDMLIKLWD-WDKKWSCSQVFEG 140
Query: 85 HTGPVLDVCWSD-DGSKVFTASCDKTAKMWDL-SSNQAIQIAQHDAPVKTIHWIKAPNYS 142
HT V+ + + D ++ +AS D+T K+W L SS+ + H+ V I + +
Sbjct: 141 HTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKGVNCIDYYSGGDKP 200
Query: 143 CVMTGSWDKTLKFWDTRSSNPMMVLQ-LPERCYCADVIYPMAVVAT-AERGLIVYQLENQ 200
+++G+ D+ +K WD ++ + L+ + CA + ++ T +E G +
Sbjct: 201 YLISGADDRLVKIWDYQNKTCVQTLEGHAQNVSCASFHPELPIIITGSEDGTV----RIW 256
Query: 201 PSEFRRIESPLKHQHR---CVAIFKDKQNKPTGFALGSI 236
S R+ES L + CVA + N G+ GSI
Sbjct: 257 HSSTYRLESTLNYGMERVWCVASLRGSNNVALGYDEGSI 295
>gi|115298668 WD repeat domain 57 (U5 snRNP specific) [Homo sapiens]
Length = 357
Score = 53.5 bits (127), Expect = 3e-07
Identities = 37/139 (26%), Positives = 65/139 (46%), Gaps = 8/139 (5%)
Query: 32 IEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLD 91
I + S + + C F P G+ L + + + W V + H+G V++
Sbjct: 59 IMLLSGHEGEVYCCKFHPN---GSTLASAGFDRLILLWNVYGDCDNYATLKG-HSGAVME 114
Query: 92 VCWSDDGSKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWI-KAPNYSCVMTGSW 149
+ ++ DGS +F+AS DKT +WD + + + ++ H + V + + + P C TGS
Sbjct: 115 LHYNTDGSMLFSASTDKTVAVWDSETGERVKRLKGHTSFVNSCYPARRGPQLVC--TGSD 172
Query: 150 DKTLKFWDTRSSNPMMVLQ 168
D T+K WD R + Q
Sbjct: 173 DGTVKLWDIRKKAAIQTFQ 191
Score = 41.6 bits (96), Expect = 0.001
Identities = 59/252 (23%), Positives = 94/252 (37%), Gaps = 31/252 (12%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSK-VFTASCDKTAKM 112
G+ L + S V W+ ++G+ + K + HT V + G + V T S D T K+
Sbjct: 121 GSMLFSASTDKTVAVWD-SETGERV-KRLKGHTSFVNSCYPARRGPQLVCTGSDDGTVKL 178
Query: 113 WDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPER 172
WD+ AIQ Q+ V + + + +++G D +K WD R +
Sbjct: 179 WDIRKKAAIQTFQNTYQVLAVTFNDTSDQ--IISGGIDNDIKVWDLRQNK---------- 226
Query: 173 CYCADVIYPMAVVATAERGLIV-----YQLENQPSEFRRI--ESPLKHQHRCVAIFKDKQ 225
+ Y M A + GL + Y L N R+ P + RCV IF Q
Sbjct: 227 -----LTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWDVRPFAPKERCVKIF---Q 278
Query: 226 NKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCH-RSNGTNTSAPQDIYAVNGIAFHPV 284
F + + + D F + S P ++N +AFHP
Sbjct: 279 GNVHNFEKNLLRCSWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPD 338
Query: 285 HGTLATVGSDGR 296
+ + SD R
Sbjct: 339 EPIIISASSDKR 350
Score = 41.6 bits (96), Expect = 0.001
Identities = 32/122 (26%), Positives = 58/122 (47%), Gaps = 14/122 (11%)
Query: 40 DSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPV-------LDV 92
DS+ LS S G++L++ + N VR W+V+ + ++ G V L
Sbjct: 236 DSVTGLSLSSE---GSYLLSNAMDNTVRVWDVRPFAPK-ERCVKIFQGNVHNFEKNLLRC 291
Query: 93 CWSDDGSKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDK 151
WS DGSK+ S D+ +WD +S + + ++ H + + + P+ +++ S DK
Sbjct: 292 SWSPDGSKIAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAF--HPDEPIIISASSDK 349
Query: 152 TL 153
L
Sbjct: 350 RL 351
>gi|4885105 chromatin assembly factor 1 subunit B [Homo sapiens]
Length = 559
Score = 53.5 bits (127), Expect = 3e-07
Identities = 38/136 (27%), Positives = 62/136 (45%), Gaps = 25/136 (18%)
Query: 41 SIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQ-------------------TIPKA 81
++ + FSP G L +G + W+V D+ + T+ K
Sbjct: 68 AVNVVRFSPT---GEILASGGDDAVILLWKVNDNKEPEQIAFQDEDEAQLNKENWTVVKT 124
Query: 82 QQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQI-AQHDAPVKTIHWIKAPN 140
+ H V D+CW+ DG+ + +AS D TA +WD+S Q I I +H + V+ + W
Sbjct: 125 LRGHLEDVYDICWATDGNLMASASVDNTAIIWDVSKGQKISIFNEHKSYVQGVTWDPLGQ 184
Query: 141 YSCVMTGSWDKTLKFW 156
Y V T S D+ L+ +
Sbjct: 185 Y--VATLSCDRVLRVY 198
Score = 31.2 bits (69), Expect = 1.5
Identities = 19/66 (28%), Positives = 29/66 (43%), Gaps = 2/66 (3%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
GN + + S N W+V GQ I + H V V W G V T SCD+ +++
Sbjct: 141 GNLMASASVDNTAIIWDVS-KGQKISIFNE-HKSYVQGVTWDPLGQYVATLSCDRVLRVY 198
Query: 114 DLSSNQ 119
+ +
Sbjct: 199 SIQKKR 204
>gi|19913371 transducin (beta)-like 1 X-linked receptor 1 [Homo
sapiens]
Length = 514
Score = 52.0 bits (123), Expect = 8e-07
Identities = 68/330 (20%), Positives = 125/330 (37%), Gaps = 43/330 (13%)
Query: 27 NPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHT 86
NP+ D+ + S D + + S + G+ + +++ GQ +P +
Sbjct: 178 NPVSDLLASGSGDSTARIWNLSENSTSGSTQLVLRHC-------IREGGQDVPSNKD--- 227
Query: 87 GPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMT 146
V + W+ +G+ + T S D A++W N A + QH P+ + W K N+ +++
Sbjct: 228 --VTSLDWNSEGTLLATGSYDGFARIWTKDGNLASTLGQHKGPIFALKWNKKGNF--ILS 283
Query: 147 GSWDKTLKFWDTRSSNPMMVLQLP-ERCYCADVIYPM-AVVATAERGLIVYQLENQPSEF 204
DKT WD + Q P DV + A+ + ++ + +
Sbjct: 284 AGVDKTTIIWDAHTGEAKQ--QFPFHSAPALDVDWQSNNTFASCSTDMCIHVC--KLGQD 339
Query: 205 RRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNG 264
R I++ H + AI D PTG L S + + + +DN N
Sbjct: 340 RPIKTFQGHTNEVNAIKWD----PTGNLLASCSDDMTLKIW---SMKQDNCVHDLQAHN- 391
Query: 265 TNTSAPQDIYAVNGIAFHP------VHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPI 318
++IY + P + LA+ D WD D + T + +P+
Sbjct: 392 ------KEIYTIKWSPTGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPV 445
Query: 319 SACCFNHNGNIFAYASSYDWSKGHEFYNPQ 348
+ F+ +G Y +S + K +N Q
Sbjct: 446 YSVAFSPDGR---YLASGSFDKCVHIWNTQ 472
Score = 38.9 bits (89), Expect = 0.007
Identities = 27/117 (23%), Positives = 53/117 (45%), Gaps = 14/117 (11%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGS---------KVFTA 104
GN L + S ++ W ++ Q H + + WS G + +A
Sbjct: 361 GNLLASCSDDMTLKIWSMKQDNCV--HDLQAHNKEIYTIKWSPTGPGTNNPNANLMLASA 418
Query: 105 SCDKTAKMWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRS 160
S D T ++WD+ I + +H PV ++ + +P+ + +GS+DK + W+T++
Sbjct: 419 SFDSTVRLWDVDRGICIHTLTKHQEPVYSVAF--SPDGRYLASGSFDKCVHIWNTQT 473
Score = 36.6 bits (83), Expect = 0.037
Identities = 30/117 (25%), Positives = 56/117 (47%), Gaps = 15/117 (12%)
Query: 8 SGFGTSGTS---MFGSATTDNHNPMKDIE------VTSSPDDSIGCLSFSPPTLPGNFLI 58
+G GT+ + M SA+ D+ + D++ + + + ++FSP G +L
Sbjct: 402 TGPGTNNPNANLMLASASFDSTVRLWDVDRGICIHTLTKHQEPVYSVAFSPD---GRYLA 458
Query: 59 AGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDL 115
+GS+ V W Q +G + + TG + +VCW+ G KV ++ D + + DL
Sbjct: 459 SGSFDKCVHIWNTQ-TGALVHSYRG--TGGIFEVCWNAAGDKVGASASDGSVCVLDL 512
Score = 34.3 bits (77), Expect = 0.18
Identities = 25/93 (26%), Positives = 40/93 (43%), Gaps = 9/93 (9%)
Query: 50 PTLPGN-------FLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVF 102
PT PG L + S+ + VR W+V D G I + H PV V +S DG +
Sbjct: 401 PTGPGTNNPNANLMLASASFDSTVRLWDV-DRGICIHTLTK-HQEPVYSVAFSPDGRYLA 458
Query: 103 TASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHW 135
+ S DK +W+ + + + + + W
Sbjct: 459 SGSFDKCVHIWNTQTGALVHSYRGTGGIFEVCW 491
>gi|70909324 sperm associated antigen 16 isoform 1 [Homo sapiens]
Length = 631
Score = 51.6 bits (122), Expect = 1e-06
Identities = 41/140 (29%), Positives = 59/140 (42%), Gaps = 28/140 (20%)
Query: 42 IGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQM-----HTGPVLDVCWSD 96
+ C+S P + L++ + R W+V +PK + HT + D C+
Sbjct: 355 VSCVSMQPHK---DILVS---CGEDRLWKVLG----LPKCNVLLTGFGHTDWLSDCCFHP 404
Query: 97 DGSKVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKF 155
G K+ T+S D T K+WDL I + H V + W N+ V + S DKT K
Sbjct: 405 SGDKLATSSGDTTVKLWDLCKGDCILTFEGHSRAVWSCTWHSCGNF--VASSSLDKTSKI 462
Query: 156 WDTRSSNPMMVLQLPERCYC 175
WD S ERC C
Sbjct: 463 WDVNS----------ERCRC 472
Score = 47.4 bits (111), Expect = 2e-05
Identities = 31/108 (28%), Positives = 53/108 (49%), Gaps = 5/108 (4%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G+ L S V+ W++ + + H+ V W G+ V ++S DKT+K+W
Sbjct: 406 GDKLATSSGDTTVKLWDLCKGDCIL--TFEGHSRAVWSCTWHSCGNFVASSSLDKTSKIW 463
Query: 114 DLSSNQA-IQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRS 160
D++S + + H V +I + P + ++T S DKTL WD R+
Sbjct: 464 DVNSERCRCTLYGHTDSVNSIEFF--PFSNTLLTSSADKTLSIWDART 509
>gi|21071067 TBP-associated factor 5 [Homo sapiens]
Length = 800
Score = 50.8 bits (120), Expect = 2e-06
Identities = 38/118 (32%), Positives = 56/118 (47%), Gaps = 8/118 (6%)
Query: 46 SFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTAS 105
SFSP N+L++ S VR W +Q T + H PV D +S G +
Sbjct: 550 SFSPDR---NYLLSSSEDGTVRLWSLQTF--TCLVGYKGHNYPVWDTQFSPYGYYFVSGG 604
Query: 106 CDKTAKMWDLSSNQAIQI-AQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSN 162
D+ A++W Q ++I A H A V + PN + V TGS D+T++ WD + N
Sbjct: 605 HDRVARLWATDHYQPLRIFAGHLADVNCTRF--HPNSNYVATGSADRTVRLWDVLNGN 660
Score = 43.9 bits (102), Expect = 2e-04
Identities = 30/136 (22%), Positives = 63/136 (46%), Gaps = 11/136 (8%)
Query: 23 TDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQ 82
TD++ P++ + + + C F P + N++ GS VR W+V + +
Sbjct: 614 TDHYQPLR---IFAGHLADVNCTRFHPNS---NYVATGSADRTVRLWDVLNGNCV--RIF 665
Query: 83 QMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNY 141
H GP+ + +S +G + T + D +WD+ + ++ H V ++ + + +
Sbjct: 666 TGHKGPIHSLTFSPNGRFLATGATDGRVLLWDIGHGLMVGELKGHTDTVCSLRFSR--DG 723
Query: 142 SCVMTGSWDKTLKFWD 157
+ +GS D T++ WD
Sbjct: 724 EILASGSMDNTVRLWD 739
Score = 37.0 bits (84), Expect = 0.028
Identities = 27/108 (25%), Positives = 52/108 (48%), Gaps = 11/108 (10%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDV-C--WSDDGSKVFTASCDKTA 110
G + ++G R W D Q + ++ G + DV C + + + V T S D+T
Sbjct: 597 GYYFVSGGHDRVARLWAT-DHYQPL----RIFAGHLADVNCTRFHPNSNYVATGSADRTV 651
Query: 111 KMWDLSSNQAIQI-AQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWD 157
++WD+ + ++I H P+ ++ + +PN + TG+ D + WD
Sbjct: 652 RLWDVLNGNCVRIFTGHKGPIHSLTF--SPNGRFLATGATDGRVLLWD 697
Score = 34.3 bits (77), Expect = 0.18
Identities = 20/83 (24%), Positives = 39/83 (46%), Gaps = 3/83 (3%)
Query: 85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSS-NQAIQIAQHDAPVKTIHWIKAPNYSC 143
H+GPV +S D + + ++S D T ++W L + + H+ PV + +P
Sbjct: 542 HSGPVYGASFSPDRNYLLSSSEDGTVRLWSLQTFTCLVGYKGHNYPVWDTQF--SPYGYY 599
Query: 144 VMTGSWDKTLKFWDTRSSNPMMV 166
++G D+ + W T P+ +
Sbjct: 600 FVSGGHDRVARLWATDHYQPLRI 622
>gi|24431950 PRP4 pre-mRNA processing factor 4 homolog [Homo
sapiens]
Length = 522
Score = 50.8 bits (120), Expect = 2e-06
Identities = 32/107 (29%), Positives = 51/107 (47%), Gaps = 5/107 (4%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G FL + R W+++ + + Q+ H+ V D+ + DGS T D ++W
Sbjct: 335 GRFLGTTCYDRSWRLWDLEAQEEILH--QEGHSMGVYDIAFHQDGSLAGTGGLDAFGRVW 392
Query: 114 DLSSNQAIQIAQHDAPVKTIHWIK-APNYSCVMTGSWDKTLKFWDTR 159
DL + + I + +K I+ I +PN + TGS D T K WD R
Sbjct: 393 DLRTGRCIMFL--EGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLR 437
Score = 40.8 bits (94), Expect = 0.002
Identities = 23/69 (33%), Positives = 35/69 (50%), Gaps = 4/69 (5%)
Query: 45 LSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTA 104
+ F P + GNFL+ G++ N + W G + K H G V+ + S DG + T
Sbjct: 455 VKFEP--IHGNFLLTGAYDNTAKIWT--HPGWSPLKTLAGHEGKVMGLDISSDGQLIATC 510
Query: 105 SCDKTAKMW 113
S D+T K+W
Sbjct: 511 SYDRTFKLW 519
Score = 38.5 bits (88), Expect = 0.010
Identities = 27/112 (24%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 58 IAGSWANDV--RCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDL 115
+AG+ D R W+++ +G+ I + H + + +S +G + T S D T K+WDL
Sbjct: 379 LAGTGGLDAFGRVWDLR-TGRCIMFLEG-HLKEIYGINFSPNGYHIATGSGDNTCKVWDL 436
Query: 116 SSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVL 167
+ + + T + + + ++TG++D T K W +P+ L
Sbjct: 437 RQRRCVYTIPAHQNLVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTL 488
Score = 35.8 bits (81), Expect = 0.063
Identities = 34/134 (25%), Positives = 61/134 (45%), Gaps = 10/134 (7%)
Query: 41 SIGCLSFSPPTL----PGNFLIAGSWAN-DVRCWEVQDSGQTIPKAQQMHTGPVLDVCWS 95
++G + F P + P + +A A+ V+ W + DS + + + HT V V W
Sbjct: 275 NVGAIVFHPKSTVSLDPKDVNLASCAADGSVKLWSL-DSDEPVADIEG-HTVRVARVMWH 332
Query: 96 DDGSKVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLK 154
G + T D++ ++WDL + + I + H V I + + + S TG D +
Sbjct: 333 PSGRFLGTTCYDRSWRLWDLEAQEEILHQEGHSMGVYDIAFHQ--DGSLAGTGGLDAFGR 390
Query: 155 FWDTRSSNPMMVLQ 168
WD R+ +M L+
Sbjct: 391 VWDLRTGRCIMFLE 404
Score = 32.0 bits (71), Expect = 0.91
Identities = 64/317 (20%), Positives = 109/317 (34%), Gaps = 52/317 (16%)
Query: 39 DDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSG--QTIPKAQQMHTGPVL---DVC 93
D I FSP + L W+ + W V D T+ + + G ++
Sbjct: 231 DRPISYCHFSPNS---KMLATACWSGLCKLWSVPDCNLLHTL-RGHNTNVGAIVFHPKST 286
Query: 94 WSDDGSKVFTASC--DKTAKMWDLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWD 150
S D V ASC D + K+W L S++ + I H V + W P+ + T +D
Sbjct: 287 VSLDPKDVNLASCAADGSVKLWSLDSDEPVADIEGHTVRVARVMW--HPSGRFLGTTCYD 344
Query: 151 KTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESP 210
++ + WD + + + Q D+ + GL F R+
Sbjct: 345 RSWRLWDLEAQEEI-LHQEGHSMGVYDIAFHQDGSLAGTGGL---------DAFGRVWD- 393
Query: 211 LKHQHRCVAIFKDKQNK-------PTGF--ALGSIEGRVAIHYINPPNPAKDNFTFKCHR 261
RC+ + + P G+ A GS + + + +T H+
Sbjct: 394 -LRTGRCIMFLEGHLKEIYGINFSPNGYHIATGSGDNTCKVWDLRQRRCV---YTIPAHQ 449
Query: 262 SNGTNTSAPQDIYAVNGIAFHPVHGTLATVGS-DGRFSFWDKDARTKLKTSEQLDQPISA 320
+ V G+ F P+HG G+ D W + LKT + +
Sbjct: 450 N------------LVTGVKFEPIHGNFLLTGAYDNTAKIWTHPGWSPLKTLAGHEGKVMG 497
Query: 321 CCFNHNGNIFAYASSYD 337
+ +G + A SYD
Sbjct: 498 LDISSDGQLIA-TCSYD 513
>gi|20357529 guanine nucleotide-binding protein, beta-2 subunit
[Homo sapiens]
Length = 340
Score = 50.4 bits (119), Expect = 2e-06
Identities = 29/116 (25%), Positives = 55/116 (47%), Gaps = 5/116 (4%)
Query: 52 LPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAK 111
L N +I S W+++ QT+ A H+G V+ + + DG + +CD + K
Sbjct: 152 LDDNQIITSSGDTTCALWDIETGQQTVGFAG--HSGDVMSLSLAPDGRTFVSGACDASIK 209
Query: 112 MWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMV 166
+WD+ + Q H++ + + + PN TGS D T + +D R+ +++
Sbjct: 210 LWDVRDSMCRQTFIGHESDINAVAFF--PNGYAFTTGSDDATCRLFDLRADQELLM 263
Score = 33.1 bits (74), Expect = 0.41
Identities = 28/124 (22%), Positives = 54/124 (43%), Gaps = 6/124 (4%)
Query: 45 LSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTA 104
LS +P G ++G+ ++ W+V+DS + H + V + +G T
Sbjct: 190 LSLAPD---GRTFVSGACDASIKLWDVRDS--MCRQTFIGHESDINAVAFFPNGYAFTTG 244
Query: 105 SCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIK-APNYSCVMTGSWDKTLKFWDTRSSNP 163
S D T +++DL ++Q + + HD + I + + + ++ G D WD +
Sbjct: 245 SDDATCRLFDLRADQELLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDR 304
Query: 164 MMVL 167
VL
Sbjct: 305 AGVL 308
Score = 32.0 bits (71), Expect = 0.91
Identities = 20/70 (28%), Positives = 31/70 (44%), Gaps = 3/70 (4%)
Query: 89 VLDVCWSDDGSKVFTASCDKTAKMWD-LSSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTG 147
+ V +S G + D +WD + ++A +A HD V + + V TG
Sbjct: 273 ITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLG--VTDDGMAVATG 330
Query: 148 SWDKTLKFWD 157
SWD LK W+
Sbjct: 331 SWDSFLKIWN 340
>gi|32189425 WD repeat domain 69 [Homo sapiens]
Length = 415
Score = 49.7 bits (117), Expect = 4e-06
Identities = 29/115 (25%), Positives = 59/115 (51%), Gaps = 5/115 (4%)
Query: 55 NFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWD 114
+ ++ GS + W+ + G+ + H +LD C+ G + TAS D TA+++
Sbjct: 274 SLILTGSMDKTCKLWDATN-GKCVATLTG-HDDEILDSCFDYTGKLIATASADGTARIFS 331
Query: 115 LSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQ 168
++ + I ++ H+ + I + N+ ++TGS DKT + WD ++ + VL+
Sbjct: 332 AATRKCIAKLEGHEGEISKISFNPQGNH--LLTGSSDKTARIWDAQTGQCLQVLE 384
Score = 47.4 bits (111), Expect = 2e-05
Identities = 31/117 (26%), Positives = 56/117 (47%), Gaps = 6/117 (5%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDD-GSKVFTASCDKTAKM 112
G+ I GS+ + W+ SG+ + + H V + +++ G K+ T S DKT K+
Sbjct: 104 GSCFITGSYDRTCKLWDTA-SGEEL-NTLEGHRNVVYAIAFNNPYGDKIATGSFDKTCKL 161
Query: 113 WDLSSNQAIQIAQ-HDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQ 168
W + + + + H A + + + P + V TGS D T K WD ++ + L+
Sbjct: 162 WSVETGKCYHTFRGHTAEIVCLSF--NPQSTLVATGSMDTTAKLWDIQNGEEVYTLR 216
Score = 45.8 bits (107), Expect = 6e-05
Identities = 24/81 (29%), Positives = 37/81 (45%)
Query: 80 KAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIKAP 139
K + H P+ +V + GS T S D+T K+WD +S + + + V P
Sbjct: 86 KVLKAHILPLTNVALNKSGSCFITGSYDRTCKLWDTASGEELNTLEGHRNVVYAIAFNNP 145
Query: 140 NYSCVMTGSWDKTLKFWDTRS 160
+ TGS+DKT K W +
Sbjct: 146 YGDKIATGSFDKTCKLWSVET 166
Score = 44.7 bits (104), Expect = 1e-04
Identities = 27/115 (23%), Positives = 60/115 (52%), Gaps = 5/115 (4%)
Query: 54 GNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
G+ + GS+ + W V+ +G+ + HT ++ + ++ + V T S D TAK+W
Sbjct: 147 GDKIATGSFDKTCKLWSVE-TGKCYHTFRG-HTAEIVCLSFNPQSTLVATGSMDTTAKLW 204
Query: 114 DLSSNQAI-QIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVL 167
D+ + + + + H A + ++ + + + ++TGS+D T+ WD + + +L
Sbjct: 205 DIQNGEEVYTLRGHSAEIISLSFNTSGDR--IITGSFDHTVVVWDADTGRKVNIL 257
Score = 44.3 bits (103), Expect = 2e-04
Identities = 24/75 (32%), Positives = 41/75 (54%), Gaps = 7/75 (9%)
Query: 85 HTGPVLDVCWSDDGSKVFTASCDKTAKMWDLSSNQAIQIAQ-HDAPVKTIHWIKAPNY-- 141
H G + + ++ G+ + T S DKTA++WD + Q +Q+ + H + + A NY
Sbjct: 344 HEGEISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSC----AFNYKG 399
Query: 142 SCVMTGSWDKTLKFW 156
+ V+TGS D T + W
Sbjct: 400 NIVITGSKDNTCRIW 414
Score = 40.8 bits (94), Expect = 0.002
Identities = 33/111 (29%), Positives = 51/111 (45%), Gaps = 13/111 (11%)
Query: 3 LFGTTSGFGTSGTSMFGSATTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSW 62
L T S GT+ +F +AT K I + I +SF+P GN L+ GS
Sbjct: 317 LIATASADGTA--RIFSAATR------KCIAKLEGHEGEISKISFNPQ---GNHLLTGSS 365
Query: 63 ANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMW 113
R W+ Q +GQ + + + HT + ++ G+ V T S D T ++W
Sbjct: 366 DKTARIWDAQ-TGQCL-QVLEGHTDEIFSCAFNYKGNIVITGSKDNTCRIW 414
Score = 34.3 bits (77), Expect = 0.18
Identities = 18/54 (33%), Positives = 25/54 (46%)
Query: 276 VNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPISACCFNHNGNI 329
++ I+F+P L T SD WD L+ E I +C FN+ GNI
Sbjct: 348 ISKISFNPQGNHLLTGSSDKTARIWDAQTGQCLQVLEGHTDEIFSCAFNYKGNI 401
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit
[Homo sapiens]
Length = 340
Score = 49.3 bits (116), Expect = 5e-06
Identities = 30/115 (26%), Positives = 52/115 (45%), Gaps = 5/115 (4%)
Query: 52 LPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAK 111
L N ++ S W+++ QT HTG V+ + + D + +CD +AK
Sbjct: 152 LDDNQIVTSSGDTTCALWDIETGQQTTTFTG--HTGDVMSLSLAPDTRLFVSGACDASAK 209
Query: 112 MWDLSSNQAIQ-IAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMM 165
+WD+ Q H++ + I + PN + TGS D T + +D R+ +M
Sbjct: 210 LWDVREGMCRQTFTGHESDINAICFF--PNGNAFATGSDDATCRLFDLRADQELM 262
Score = 35.8 bits (81), Expect = 0.063
Identities = 29/127 (22%), Positives = 56/127 (44%), Gaps = 12/127 (9%)
Query: 45 LSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDV---CWSDDGSKV 101
LS +P T ++G+ + W+V++ +Q TG D+ C+ +G+
Sbjct: 190 LSLAPDT---RLFVSGACDASAKLWDVREG-----MCRQTFTGHESDINAICFFPNGNAF 241
Query: 102 FTASCDKTAKMWDLSSNQAIQIAQHDAPVKTIHWIK-APNYSCVMTGSWDKTLKFWDTRS 160
T S D T +++DL ++Q + HD + I + + + ++ G D WD
Sbjct: 242 ATGSDDATCRLFDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALK 301
Query: 161 SNPMMVL 167
++ VL
Sbjct: 302 ADRAGVL 308
Score = 35.8 bits (81), Expect = 0.063
Identities = 34/150 (22%), Positives = 59/150 (39%), Gaps = 12/150 (8%)
Query: 15 TSMFGSATTDNHNPMKDI------EVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRC 68
T +F S D + D+ + + + I + F P GN GS R
Sbjct: 196 TRLFVSGACDASAKLWDVREGMCRQTFTGHESDINAICFFPN---GNAFATGSDDATCRL 252
Query: 69 WEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWD-LSSNQAIQIAQHD 127
++++ + + + + V +S G + D +WD L +++A +A HD
Sbjct: 253 FDLRADQELMTYSHDNIICGITSVSFSKSGRLLLAGYDDFNCNVWDALKADRAGVLAGHD 312
Query: 128 APVKTIHWIKAPNYSCVMTGSWDKTLKFWD 157
V + + V TGSWD LK W+
Sbjct: 313 NRVSCLG--VTDDGMAVATGSWDSFLKIWN 340
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.132 0.422
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,552,329
Number of Sequences: 37866
Number of extensions: 722167
Number of successful extensions: 2785
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 122
Number of HSP's successfully gapped in prelim test: 111
Number of HSP's that attempted gapping in prelim test: 1682
Number of HSP's gapped (non-prelim): 941
length of query: 368
length of database: 18,247,518
effective HSP length: 104
effective length of query: 264
effective length of database: 14,309,454
effective search space: 3777695856
effective search space used: 3777695856
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.