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Search of human proteins with 4506141
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]
(480 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens] 954 0.0
gi|22129776 HtrA serine peptidase 3 [Homo sapiens] 511 e-145
gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens] 474 e-134
gi|7019477 HtrA serine peptidase 2 isoform 1 preproprotein [Homo... 330 1e-90
gi|21614538 HtrA serine peptidase 2 isoform 2 [Homo sapiens] 115 7e-26
gi|4504619 insulin-like growth factor binding protein 7 [Homo sa... 105 9e-23
gi|19923632 Kazal-type serine peptidase inhibitor domain 1 precu... 91 2e-18
gi|56090548 insulin-like growth factor binding protein-like 1 [H... 88 2e-17
gi|62243068 insulin-like growth factor binding protein 3 isoform... 60 3e-09
gi|62243248 insulin-like growth factor binding protein 3 isoform... 60 3e-09
gi|55925576 insulin-like growth factor binding protein 2, 36kDa ... 57 4e-08
gi|4504615 insulin-like growth factor binding protein 1 precurso... 55 1e-07
gi|10834982 insulin-like growth factor binding protein 5 [Homo s... 53 7e-07
gi|62243290 insulin-like growth factor binding protein 4 precurs... 52 2e-06
gi|5901946 endothelial cell-specific molecule 1 isoform a precur... 50 6e-06
gi|208022668 endothelial cell-specific molecule 1 isoform b prec... 50 6e-06
gi|11321593 insulin-like growth factor binding protein 6 [Homo s... 49 1e-05
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens] 48 2e-05
gi|54873613 agrin [Homo sapiens] 46 7e-05
gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens] 46 9e-05
gi|4885363 goosecoid homeobox 2 [Homo sapiens] 45 2e-04
gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens] 44 4e-04
gi|4503123 connective tissue growth factor [Homo sapiens] 43 6e-04
gi|21361142 PDZ domain containing 1 [Homo sapiens] 43 6e-04
gi|4507923 WNT1 inducible signaling pathway protein 2 precursor ... 40 0.005
gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3... 40 0.006
gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1 ... 40 0.006
gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo s... 40 0.006
gi|30387656 late cornified envelope 1B [Homo sapiens] 40 0.006
gi|30387652 late cornified envelope 1C [Homo sapiens] 39 0.008
>gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]
Length = 480
Score = 954 bits (2466), Expect = 0.0
Identities = 480/480 (100%), Positives = 480/480 (100%)
Query: 1 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD 60
MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD
Sbjct: 1 MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARD 60
Query: 61 ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG 120
ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG
Sbjct: 61 ACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCG 120
Query: 121 SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA 180
SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA
Sbjct: 121 SDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIA 180
Query: 181 PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA 240
PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA
Sbjct: 181 PAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEA 240
Query: 241 KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT 300
KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT
Sbjct: 241 KIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTT 300
Query: 301 QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI 360
QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI
Sbjct: 301 QRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKI 360
Query: 361 KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD 420
KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD
Sbjct: 361 KKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPD 420
Query: 421 TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP 480
TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP
Sbjct: 421 TPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP 480
>gi|22129776 HtrA serine peptidase 3 [Homo sapiens]
Length = 453
Score = 511 bits (1315), Expect = e-145
Identities = 270/472 (57%), Positives = 343/472 (72%), Gaps = 32/472 (6%)
Query: 14 LLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEG 73
LLLAA A+ L+R P AA CP RC+ +RCP C GG D C CC VC A EG
Sbjct: 6 LLLAALAALALARE----PPAAPCPARCDVSRCPSP--RCPGGYVPDLCNCCLVCAASEG 59
Query: 74 AACGLQ-EGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQL 132
CG + PCGE L+CV GLC C S VCG+D +TYAN+C L
Sbjct: 60 EPCGGPLDSPCGESLECV----------------RGLCRCRWSHAVCGTDGHTYANVCAL 103
Query: 133 RAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKL 192
+AASRR+ +L PV LQ+GAC G +S R+K+NFIADVVEKIAPAVVHIELF +
Sbjct: 104 QAASRRALQLSGTPVRQLQKGACPLGLHQLSSPRYKFNFIADVVEKIAPAVVHIELFLRH 163
Query: 193 PFSKREVPVASGSGFIVSEDGLIVTNAHVVTN------KHRVKVELKNGATYEAKIKDVD 246
P R VP++SGSGFI+SE GLI+TNAHVV++ + ++KV+L+NG +YEA IKD+D
Sbjct: 164 PLFGRNVPLSSGSGFIMSEAGLIITNAHVVSSNSAAPGRQQLKVQLQNGDSYEATIKDID 223
Query: 247 EKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKE 306
+K+DIA IKI + KLPVLLLG S++LRPGEFVVAIGSPF+LQNTVTTGIVST QR G+E
Sbjct: 224 KKSDIATIKIHPKKKLPVLLLGHSADLRPGEFVVAIGSPFALQNTVTTGIVSTAQREGRE 283
Query: 307 LGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTE 366
LGLR+SDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSD+I +FLTE
Sbjct: 284 LGLRDSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDRITRFLTE 343
Query: 367 SHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAG 426
D+Q K KK++IGIRM ++T S ELK + DFP+V SG Y+ EV P++P++ G
Sbjct: 344 FQDKQIKD---WKKRFIGIRMRTITPSLVDELKASNPDFPEVSSGIYVQEVAPNSPSQRG 400
Query: 427 GLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEI 478
G+++ D+I+ +NG+ +V ++++ + + ES L + VRRGN+D++ ++ PE +
Sbjct: 401 GIQDGDIIVKVNGRPLVDSSELQEAVLTESPLLLEVRRGNDDLLFSIAPEVV 452
>gi|24308541 HtrA serine peptidase 4 precursor [Homo sapiens]
Length = 476
Score = 474 bits (1220), Expect = e-134
Identities = 251/478 (52%), Positives = 328/478 (68%), Gaps = 22/478 (4%)
Query: 8 LLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGR-ARDACGCCE 66
LLP LLLLL A + CP C+P RCP P G D C CC
Sbjct: 15 LLPGLLLLLVPVLWAGAEKLHTQP----SCPAVCQPTRCPALPTCALGTTPVFDLCRCCR 70
Query: 67 VCGAPEGAACGLQEG-PCGEGLQCVVPF--GVPASATVRRRAQAGLCVCAS-SEPVCGSD 122
VC A E CG +G PC GLQC+ P G P++ C C + VCGSD
Sbjct: 71 VCPAAEREVCGGAQGQPCAPGLQCLQPLRPGFPST-----------CGCPTLGGAVCGSD 119
Query: 123 ANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQ-GQEDPNSLRHKYNFIADVVEKIAP 181
TY ++C LRA +R + RL + P + +Q G CG G LR YNFIA VVEK+AP
Sbjct: 120 RRTYPSMCALRAENRAARRLGKVPAVPVQWGNCGDTGTRSAGPLRRNYNFIAAVVEKVAP 179
Query: 182 AVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAK 241
+VVH++L+ +L R VPV SGSGFIVSEDGLI+TNAHVV N+ ++V L+NGA YEA
Sbjct: 180 SVVHVQLWGRLLHGSRLVPVYSGSGFIVSEDGLIITNAHVVRNQQWIEVVLQNGARYEAV 239
Query: 242 IKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQ 301
+KD+D K D+A+IKI+ +LPVL+LGRSS+LR GEFVVA+GSPFSLQNT T GIVST Q
Sbjct: 240 VKDIDLKLDLAVIKIESNAELPVLMLGRSSDLRAGEFVVALGSPFSLQNTATAGIVSTKQ 299
Query: 302 RGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIK 361
RGGKELG+++SDMDY+Q DA INYGNSGGPLVNLDG+VIG+N+L+VT GISFAIPSD+++
Sbjct: 300 RGGKELGMKDSDMDYVQIDATINYGNSGGPLVNLDGDVIGVNSLRVTDGISFAIPSDRVR 359
Query: 362 KFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDT 421
+FL E H+ Q KGKA + KKY+G++M+SLT ++ELK + DFPDV SG Y+ +V+ T
Sbjct: 360 QFLAEYHEHQMKGKAFSNKKYLGLQMLSLTVPLSEELKMHYPDFPDVSSGVYVCKVVEGT 419
Query: 422 PAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEID 479
A++ GL+++DVI++ING+ + + DV + +S L+M V RG +++++TVIPE I+
Sbjct: 420 AAQSSGLRDHDVIVNINGKPITTTTDVVKALDSDS-LSMAVLRGKDNLLLTVIPETIN 476
>gi|7019477 HtrA serine peptidase 2 isoform 1 preproprotein [Homo
sapiens]
Length = 458
Score = 330 bits (847), Expect = 1e-90
Identities = 170/316 (53%), Positives = 235/316 (74%), Gaps = 1/316 (0%)
Query: 162 PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHV 221
P S R +YNFIADVVEK APAVV+IE+ + PF REVP+++GSGF+V+ DGLIVTNAHV
Sbjct: 140 PASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHV 199
Query: 222 VTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVA 281
V ++ RV+V L +G TYEA + VD ADIA ++I + LP L LGRS+++R GEFVVA
Sbjct: 200 VADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRIQTKEPLPTLPLGRSADVRQGEFVVA 259
Query: 282 IGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIG 341
+GSPF+LQNT+T+GIVS+ QR ++LGL ++++YIQTDA I++GNSGGPLVNLDGEVIG
Sbjct: 260 MGSPFALQNTITSGIVSSAQRPARDLGLPQTNVEYIQTDAAIDFGNSGGPLVNLDGEVIG 319
Query: 342 INTLKVTAGISFAIPSDKIKKFLTESHDR-QAKGKAITKKKYIGIRMMSLTSSKAKELKD 400
+NT+KVTAGISFAIPSD++++FL + + G + ++++YIG+ M++L+ S EL+
Sbjct: 320 VNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYIGVMMLTLSPSILAELQL 379
Query: 401 RHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNM 460
R FPDV G I +VI +PA GL+ DVI++I Q V +A DV + ++ +S L +
Sbjct: 380 REPSFPDVQHGVLIHKVILGSPAHRAGLRPGDVILAIGEQMVQNAEDVYEAVRTQSQLAV 439
Query: 461 VVRRGNEDIMITVIPE 476
+RRG E + + V PE
Sbjct: 440 QIRRGRETLTLYVTPE 455
>gi|21614538 HtrA serine peptidase 2 isoform 2 [Homo sapiens]
Length = 361
Score = 115 bits (289), Expect = 7e-26
Identities = 58/95 (61%), Positives = 74/95 (77%)
Query: 162 PNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHV 221
P S R +YNFIADVVEK APAVV+IE+ + PF REVP+++GSGF+V+ DGLIVTNAHV
Sbjct: 140 PASPRSQYNFIADVVEKTAPAVVYIEILDRHPFLGREVPISNGSGFVVAADGLIVTNAHV 199
Query: 222 VTNKHRVKVELKNGATYEAKIKDVDEKADIALIKI 256
V ++ RV+V L +G TYEA + VD ADIA ++I
Sbjct: 200 VADRRRVRVRLLSGDTYEAVVTAVDPVADIATLRI 234
Score = 106 bits (264), Expect = 5e-23
Identities = 59/153 (38%), Positives = 89/153 (58%), Gaps = 33/153 (21%)
Query: 325 YGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDR-QAKGKAITKKKYI 383
+GNSGGPLVNLDGEVIG+NT+KVTAGISFAIPSD++++FL + + G + ++++YI
Sbjct: 238 FGNSGGPLVNLDGEVIGVNTMKVTAGISFAIPSDRLREFLHRGEKKNSSSGISGSQRRYI 297
Query: 384 GIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVV 443
G+ M++L + GL+ DVI++I Q V
Sbjct: 298 GVMMLTL--------------------------------SPRAGLRPGDVILAIGEQMVQ 325
Query: 444 SANDVSDVIKRESTLNMVVRRGNEDIMITVIPE 476
+A DV + ++ +S L + +RRG E + + V PE
Sbjct: 326 NAEDVYEAVRTQSQLAVQIRRGRETLTLYVTPE 358
>gi|4504619 insulin-like growth factor binding protein 7 [Homo
sapiens]
Length = 282
Score = 105 bits (262), Expect = 9e-23
Identities = 64/162 (39%), Positives = 79/162 (48%), Gaps = 32/162 (19%)
Query: 11 LLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPE-HCEGGRARDACGCCEVCG 69
LLLLLL +S+ G CEPA CPP P C G RDACGCC +C
Sbjct: 16 LLLLLLPLSSSSSSDTCGP-----------CEPASCPPLPPLGCLLGETRDACGCCPMCA 64
Query: 70 APEGAAC---GLQEGPCGEGLQCVVPFGVPASATVRRRAQA----------GLCVCASSE 116
EG C G G C G++CV + RR+ +A G+CVC S
Sbjct: 65 RGEGEPCGGGGAGRGYCAPGMECV-------KSRKRRKGKAGAAAGGPGVSGVCVCKSRY 117
Query: 117 PVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQG 158
PVCGSD TY + CQLRAAS+R+E + + +G C QG
Sbjct: 118 PVCGSDGTTYPSGCQLRAASQRAESRGEKAITQVSKGTCEQG 159
>gi|19923632 Kazal-type serine peptidase inhibitor domain 1
precursor [Homo sapiens]
Length = 304
Score = 91.3 bits (225), Expect = 2e-18
Identities = 70/185 (37%), Positives = 85/185 (45%), Gaps = 29/185 (15%)
Query: 4 PRAAL-LPLLLLLLAA----PASAQLS------RAGRSAPLAAG--CPDRCEPARCPPQP 50
P AAL LP+LLLLL P A+ S R G LA G C C P C P
Sbjct: 7 PAAALALPVLLLLLVVLTPPPTGARPSPGPDYLRRGWMRLLAEGEGCAP-CRPEECAA-P 64
Query: 51 EHCEGGRARDACGCCEVCGAPEGAACGLQE-----GPCGEGLQCVVPFGVPASATVRRRA 105
C GR RDACGCC C EG C L G CGE L+C + G S R
Sbjct: 65 RGCLAGRVRDACGCCWECANLEGQLCDLDPSAHFYGHCGEQLECRLDTGGDLS---RGEV 121
Query: 106 QAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSL 165
LC C S P+CGSD +TY+ +C+L+ A+R + + V G C G P +
Sbjct: 122 PEPLCACRSQSPLCGSDGHTYSQICRLQEAARARPDAN---LTVAHPGPCESG---PQIV 175
Query: 166 RHKYN 170
H Y+
Sbjct: 176 SHPYD 180
>gi|56090548 insulin-like growth factor binding protein-like 1 [Homo
sapiens]
Length = 278
Score = 87.8 bits (216), Expect = 2e-17
Identities = 59/157 (37%), Positives = 73/157 (46%), Gaps = 10/157 (6%)
Query: 3 IPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPD--RCEPARCP-PQPEHCEGGRAR 59
+PR +LL LLLLL P LS + + P C P CP P P G A
Sbjct: 1 MPRLSLLLPLLLLLLLPLLPPLSPSLGIRDVGGRRPKCGPCRPEGCPAPAPCPAPGISAL 60
Query: 60 DACGCCEVCGAPEGAACGLQEGP-CGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPV 118
D CGCC C EGA+CG + G CG GL C + A GLCVCA V
Sbjct: 61 DECGCCARCLGAEGASCGGRAGGRCGPGLVCA------SQAAGAAPEGTGLCVCAQRGTV 114
Query: 119 CGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGAC 155
CGSD +Y ++C LR +R + R H + + G C
Sbjct: 115 CGSDGRSYPSVCALRLRARHTPRAHPGHLHKARDGPC 151
>gi|62243068 insulin-like growth factor binding protein 3 isoform b
precursor [Homo sapiens]
Length = 291
Score = 60.5 bits (145), Expect = 3e-09
Identities = 46/121 (38%), Positives = 54/121 (44%), Gaps = 22/121 (18%)
Query: 6 AALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEP------ARCPPQPEHCEGGRAR 59
AA L LL+LL P ++RAG S+ G RCEP A+C P P C
Sbjct: 10 AAALTLLVLLRGPP----VARAGASSA-GLGPVVRCEPCDARALAQCAPPPAVCAELVRE 64
Query: 60 DACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQA-----GLCVCAS 114
CGCC C EG CG+ CG GL+C S R QA GLCV AS
Sbjct: 65 PGCGCCLTCALSEGQPCGIYTERCGSGLRC------QPSPDEARPLQALLDGRGLCVNAS 118
Query: 115 S 115
+
Sbjct: 119 A 119
>gi|62243248 insulin-like growth factor binding protein 3 isoform a
precursor [Homo sapiens]
Length = 297
Score = 60.5 bits (145), Expect = 3e-09
Identities = 46/121 (38%), Positives = 54/121 (44%), Gaps = 22/121 (18%)
Query: 6 AALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEP------ARCPPQPEHCEGGRAR 59
AA L LL+LL P ++RAG S+ G RCEP A+C P P C
Sbjct: 10 AAALTLLVLLRGPP----VARAGASSA-GLGPVVRCEPCDARALAQCAPPPAVCAELVRE 64
Query: 60 DACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQA-----GLCVCAS 114
CGCC C EG CG+ CG GL+C S R QA GLCV AS
Sbjct: 65 PGCGCCLTCALSEGQPCGIYTERCGSGLRC------QPSPDEARPLQALLDGRGLCVNAS 118
Query: 115 S 115
+
Sbjct: 119 A 119
>gi|55925576 insulin-like growth factor binding protein 2, 36kDa
[Homo sapiens]
Length = 328
Score = 57.0 bits (136), Expect = 4e-08
Identities = 39/104 (37%), Positives = 43/104 (41%), Gaps = 23/104 (22%)
Query: 4 PRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPAR---------CPPQPEHCE 54
P LLPLLLLLL A G A + CP C P R PP
Sbjct: 16 PLLPLLPLLLLLLGASGGG----GGARAEVLFRCPP-CTPERLAACGPPPVAPPAAVAAV 70
Query: 55 GGRAR---------DACGCCEVCGAPEGAACGLQEGPCGEGLQC 89
G AR CGCC VC EG ACG+ CG+GL+C
Sbjct: 71 AGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRC 114
>gi|4504615 insulin-like growth factor binding protein 1 precursor
[Homo sapiens]
Length = 259
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/85 (36%), Positives = 35/85 (41%), Gaps = 7/85 (8%)
Query: 33 LAAGCPDRCEP------ARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEG 86
+ AG P +C P A CPP C CGCC +C P GAACG+ C G
Sbjct: 22 VTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARG 81
Query: 87 LQCVVPFGVPASATVRRRAQAGLCV 111
L C G R Q G CV
Sbjct: 82 LSCRALPGEQQPLHALTRGQ-GACV 105
>gi|10834982 insulin-like growth factor binding protein 5 [Homo
sapiens]
Length = 272
Score = 52.8 bits (125), Expect = 7e-07
Identities = 33/89 (37%), Positives = 41/89 (46%), Gaps = 16/89 (17%)
Query: 8 LLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEP------ARCPPQPEHCEGGRARDA 61
LL +LLLLAA A S G CEP + CPP P CE +
Sbjct: 3 LLTAVLLLLAAYAGPAQS---------LGSFVHCEPCDEKALSMCPPSPLGCELVK-EPG 52
Query: 62 CGCCEVCGAPEGAACGLQEGPCGEGLQCV 90
CGCC C EG +CG+ C +GL+C+
Sbjct: 53 CGCCMTCALAEGQSCGVYTERCAQGLRCL 81
>gi|62243290 insulin-like growth factor binding protein 4 precursor
[Homo sapiens]
Length = 258
Score = 51.6 bits (122), Expect = 2e-06
Identities = 40/109 (36%), Positives = 45/109 (41%), Gaps = 13/109 (11%)
Query: 8 LLPLLL---LLLAAPASAQLSRAGRSAPLAAGCPDRCEP--ARCPPQPEHCEGGRARDAC 62
+LPL L LLLAA L A CP E ARC P P CE C
Sbjct: 1 MLPLCLVAALLLAAGPGPSLGDE------AIHCPPCSEEKLARCRP-PVGCEELVREPGC 53
Query: 63 GCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCV 111
GCC C G CG+ CG GL+C P GV Q G+C+
Sbjct: 54 GCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQ-GVCM 101
>gi|5901946 endothelial cell-specific molecule 1 isoform a
precursor [Homo sapiens]
Length = 184
Score = 49.7 bits (117), Expect = 6e-06
Identities = 31/84 (36%), Positives = 36/84 (42%), Gaps = 10/84 (11%)
Query: 11 LLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGA 70
LLL L PA A S A CP C+ + C P C+ D CGCC VC A
Sbjct: 5 LLLTTLLVPAHLV---AAWSNNYAVDCPQHCDSSECKSSPR-CKR-TVLDDCGCCRVCAA 59
Query: 71 PEGAAC-----GLQEGPCGEGLQC 89
G C G+ CG GL+C
Sbjct: 60 GRGETCYRTVSGMDGMKCGPGLRC 83
>gi|208022668 endothelial cell-specific molecule 1 isoform b
precursor [Homo sapiens]
Length = 134
Score = 49.7 bits (117), Expect = 6e-06
Identities = 31/84 (36%), Positives = 36/84 (42%), Gaps = 10/84 (11%)
Query: 11 LLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGA 70
LLL L PA A S A CP C+ + C P C+ D CGCC VC A
Sbjct: 5 LLLTTLLVPAHLV---AAWSNNYAVDCPQHCDSSECKSSPR-CKR-TVLDDCGCCRVCAA 59
Query: 71 PEGAAC-----GLQEGPCGEGLQC 89
G C G+ CG GL+C
Sbjct: 60 GRGETCYRTVSGMDGMKCGPGLRC 83
>gi|11321593 insulin-like growth factor binding protein 6 [Homo
sapiens]
Length = 240
Score = 48.5 bits (114), Expect = 1e-05
Identities = 31/85 (36%), Positives = 36/85 (42%), Gaps = 8/85 (9%)
Query: 8 LLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEV 67
LL L LLL A+P A G + AGCP C E +GG + C E
Sbjct: 11 LLLLALLLAASPGGALARCPGCGQGVQAGCPGGCV--------EEEDGGSPAEGCAEAEG 62
Query: 68 CGAPEGAACGLQEGPCGEGLQCVVP 92
C EG CG+ C GLQC P
Sbjct: 63 CLRREGQECGVYTPNCAPGLQCHPP 87
>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
Length = 1036
Score = 48.1 bits (113), Expect = 2e-05
Identities = 33/108 (30%), Positives = 49/108 (45%), Gaps = 21/108 (19%)
Query: 7 ALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPD-RCEPARCPPQPEHCEGGRARDACGCC 65
+LL LLLLL +R+G A + C + +CE +P +C G + CGCC
Sbjct: 19 SLLGLLLLL---------ARSGTRALVCLPCDESKCE------EPRNCPGSIVQGVCGCC 63
Query: 66 EVCGAPEGAACGLQ---EGPCGEGLQCVVPFGVPASATVRRRAQAGLC 110
C + +CG G C GL+CV+ P + +AG+C
Sbjct: 64 YTCASQRNESCGGTFGIYGTCDRGLRCVI--RPPLNGDSLTEYEAGVC 109
>gi|54873613 agrin [Homo sapiens]
Length = 2045
Score = 46.2 bits (108), Expect = 7e-05
Identities = 35/105 (33%), Positives = 43/105 (40%), Gaps = 23/105 (21%)
Query: 41 CEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASAT 100
C+P P+ C GRA GC AP A C E C G +CV G
Sbjct: 868 CKPGVAGPKCGQCPDGRALGPAGCEADASAP--ATCA--EMRCEFGARCVEESG------ 917
Query: 101 VRRRAQAGLCVC-------ASSEPVCGSDANTYANLCQLRAASRR 138
+ CVC A++ VCGSD TY N CQL+ + R
Sbjct: 918 ------SAHCVCPMLTCPEANATKVCGSDGVTYGNECQLKTIACR 956
Score = 44.7 bits (104), Expect = 2e-04
Identities = 33/88 (37%), Positives = 40/88 (45%), Gaps = 21/88 (23%)
Query: 83 CGEGLQCVVPFGVPASATVRRRAQAGLCVCASSE------PVCGSDANTYANLCQLRAAS 136
CG G C P A+ CVC S PVCGSDA+TY+N C+L+ A
Sbjct: 177 CGFGAVCEPNAEGPGRAS---------CVCKKSPCPSVVAPVCGSDASTYSNECELQRAQ 227
Query: 137 RRSERLHRPPVIVLQRGACGQGQEDPNS 164
+R R +L RG C G DP S
Sbjct: 228 CSQQRRIR----LLSRGPC--GSRDPCS 249
Score = 44.7 bits (104), Expect = 2e-04
Identities = 31/102 (30%), Positives = 42/102 (41%), Gaps = 22/102 (21%)
Query: 53 CEGGRARDACGCCEVC-----------GAPEGAACGLQEGPCGEGLQCVVPFGVPASATV 101
C + AC C + C G G+AC L+ C G + V P
Sbjct: 479 CAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCG 538
Query: 102 RRR------AQAGLCVCAS-----SEPVCGSDANTYANLCQL 132
+ R A+ G CVC S ++PVCGSD +TY + C L
Sbjct: 539 QCRFGALCEAETGRCVCPSECVALAQPVCGSDGHTYPSECML 580
Score = 40.4 bits (93), Expect = 0.004
Identities = 42/139 (30%), Positives = 55/139 (39%), Gaps = 28/139 (20%)
Query: 37 CPDRCEPARCPPQPEHC--EGGRARDAC-----GCCEVCGAPEGAACGLQEGPCGEGLQC 89
CP RCE PP C +G AC C + E A ++ CG G
Sbjct: 620 CP-RCEH---PPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQAECGSGGSG 675
Query: 90 VVPFGVPASATVRRR-------AQAGLCVCASS------EPVCGSDANTYANLCQLRAAS 136
G R+R ++ G CVC S PVCGSD TY+ C+L+ A
Sbjct: 676 SGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKAR 735
Query: 137 RRSERLHRPPVIVLQRGAC 155
S+R + V +GAC
Sbjct: 736 CESQR----GLYVAAQGAC 750
Score = 38.9 bits (89), Expect = 0.010
Identities = 35/125 (28%), Positives = 54/125 (43%), Gaps = 16/125 (12%)
Query: 41 CEPARCPP--QPEHCEGGRARDA-CGCCEVCGAPEGAACGLQEGPCGE------GLQCVV 91
C+ C +P + GR D+ C + + A +GPC + G+QC
Sbjct: 416 CDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCA- 474
Query: 92 PFGVPASATVRRRAQAGLCVCASS-EPVCGSDANTYANLCQLRAASRRSERLHRPPVIVL 150
FG + + A L C+S +PVCGSD TY + C+L A + R + V
Sbjct: 475 -FGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSACELEATACTLGR----EIQVA 529
Query: 151 QRGAC 155
++G C
Sbjct: 530 RKGPC 534
Score = 32.3 bits (72), Expect = 0.98
Identities = 33/119 (27%), Positives = 42/119 (35%), Gaps = 19/119 (15%)
Query: 41 CEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACG-------LQEGPCGEGLQC---V 90
C+ + CP G A CE+ + A C L GPCG C
Sbjct: 197 CKKSPCPSVVAPVCGSDASTYSNECEL----QRAQCSQQRRIRLLSRGPCGSRDPCSNVT 252
Query: 91 VPFGVPASATVRRRAQAGLCVC----ASSEPVCGSDANTYANLCQ-LRAASRRSERLHR 144
FG + + + LC A VCGSD Y CQ LR A R E + +
Sbjct: 253 CSFGSTCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFK 311
>gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]
Length = 357
Score = 45.8 bits (107), Expect = 9e-05
Identities = 25/57 (43%), Positives = 27/57 (47%), Gaps = 6/57 (10%)
Query: 37 CPDRCEPARCPPQPEHCEGG--RARDACGCCEVCGAPEGAACGLQEGPCGE--GLQC 89
CP +C P RCP P C G D C CC VC G +C E PC E GL C
Sbjct: 35 CPPQC-PGRCPATPPTCAPGVRAVLDGCSCCLVCARQRGESCSDLE-PCDESSGLYC 89
>gi|4885363 goosecoid homeobox 2 [Homo sapiens]
Length = 205
Score = 44.7 bits (104), Expect = 2e-04
Identities = 34/110 (30%), Positives = 43/110 (39%), Gaps = 18/110 (16%)
Query: 16 LAAPASAQLSRAGRSAP-------LAAGCPDRCEPAR--CPPQPEHCE--------GGRA 58
+AA A SR G P + + P+R PAR CPPQP + G
Sbjct: 1 MAAAAGGAASRRGAGRPCPFSIEHILSSLPERSLPARAACPPQPAGRQSPAKPEEPGAPE 60
Query: 59 RDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAG 108
C CC CG P A CG E G G + P + + + A AG
Sbjct: 61 AAPCACCCCCG-PRAAPCGPPEAAAGLGARLAWPLRLGPAVPLSLGAPAG 109
>gi|31542331 cysteine-rich, angiogenic inducer, 61 [Homo sapiens]
Length = 381
Score = 43.5 bits (101), Expect = 4e-04
Identities = 42/129 (32%), Positives = 55/129 (42%), Gaps = 25/129 (19%)
Query: 2 QIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDA 61
+I RA L + LL L A + + P A CP E +C P G RD
Sbjct: 4 RIARALALVVTLLHLTRLALS-------TCPAACHCP--LEAPKCAPGV-----GLVRDG 49
Query: 62 CGCCEVCGAPEGAACGLQEGPCG--EGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVC 119
CGCC+VC C + PC +GL+C FG AS+T A G+C S C
Sbjct: 50 CGCCKVCAKQLNEDCSKTQ-PCDHTKGLEC--NFG--ASST----ALKGICRAQSEGRPC 100
Query: 120 GSDANTYAN 128
++ Y N
Sbjct: 101 EYNSRIYQN 109
>gi|4503123 connective tissue growth factor [Homo sapiens]
Length = 349
Score = 43.1 bits (100), Expect = 6e-04
Identities = 28/80 (35%), Positives = 35/80 (43%), Gaps = 14/80 (17%)
Query: 43 PARCPPQPE-HCEGGRAR--DACGCCEVCGAPEGAACGLQEGPCG--EGLQCVVPFGVPA 97
P RCP +P C G + D CGCC VC G C + PC +GL C FG PA
Sbjct: 32 PCRCPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELC-TERDPCDPHKGLFC--DFGSPA 88
Query: 98 SATVRRRAQAGLCVCASSEP 117
+ + G+C P
Sbjct: 89 NRKI------GVCTAKDGAP 102
>gi|21361142 PDZ domain containing 1 [Homo sapiens]
Length = 519
Score = 43.1 bits (100), Expect = 6e-04
Identities = 21/69 (30%), Positives = 40/69 (57%), Gaps = 8/69 (11%)
Query: 411 GAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIM 470
G I ++ +PAE GLK ND+++++NG+SV + + +S + M +R+G +
Sbjct: 265 GQIIKDIDSGSPAEEAGLKNNDLVVAVNGESV-------ETLDHDSVVEM-IRKGGDQTS 316
Query: 471 ITVIPEEID 479
+ V+ +E D
Sbjct: 317 LLVVDKETD 325
Score = 33.9 bits (76), Expect = 0.34
Identities = 15/35 (42%), Positives = 24/35 (68%)
Query: 409 ISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVV 443
+ G++I EV PA+ GL++ DVII +NG +V+
Sbjct: 398 LPGSFIKEVQKGGPADLAGLEDEDVIIEVNGVNVL 432
Score = 30.8 bits (68), Expect = 2.8
Identities = 17/69 (24%), Positives = 33/69 (47%), Gaps = 8/69 (11%)
Query: 411 GAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIM 470
G Y+ ++ P A G+ +D +I +NG++V A+ V K V++ +M
Sbjct: 157 GVYMTDITPQGVAMRAGVLADDHLIEVNGENVEDASHEEVVEK--------VKKSGSRVM 208
Query: 471 ITVIPEEID 479
++ +E D
Sbjct: 209 FLLVDKETD 217
>gi|4507923 WNT1 inducible signaling pathway protein 2 precursor
[Homo sapiens]
Length = 250
Score = 40.0 bits (92), Expect = 0.005
Identities = 31/104 (29%), Positives = 36/104 (34%), Gaps = 31/104 (29%)
Query: 4 PRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGG--RARDA 61
P+ LL LL L + QL CP C CP P C G D
Sbjct: 5 PKTHLLAFSLLCLLSKVRTQL------------CPTPCT---CPWPPPRCPLGVPLVLDG 49
Query: 62 CGCCEVCG--------------APEGAACGLQEGPCGEGLQCVV 91
CGCC VC A +G C GP G G C++
Sbjct: 50 CGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLL 93
>gi|38202241 WNT1 inducible signaling pathway protein 3 isoform 3
[Homo sapiens]
Length = 372
Score = 39.7 bits (91), Expect = 0.006
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 43 PARCPPQPEHCEGGRA--RDACGCCEVCGAPEGAAC 76
P +CP Q C G + RD CGCC++C G C
Sbjct: 69 PCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEIC 104
>gi|4507925 WNT1 inducible signaling pathway protein 3 isoform 1
[Homo sapiens]
Length = 354
Score = 39.7 bits (91), Expect = 0.006
Identities = 15/36 (41%), Positives = 19/36 (52%), Gaps = 2/36 (5%)
Query: 43 PARCPPQPEHCEGGRA--RDACGCCEVCGAPEGAAC 76
P +CP Q C G + RD CGCC++C G C
Sbjct: 51 PCKCPQQKPRCPPGVSLVRDGCGCCKICAKQPGEIC 86
>gi|4759140 sodium/hydrogen exchanger regulatory factor 1 [Homo
sapiens]
Length = 358
Score = 39.7 bits (91), Expect = 0.006
Identities = 21/69 (30%), Positives = 34/69 (49%), Gaps = 8/69 (11%)
Query: 411 GAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIM 470
G +I V PD+PAEA GL+ D I+ +NG + K+ + +R G ++
Sbjct: 176 GQFIRSVDPDSPAEASGLRAQDRIVEVNGVCMEG--------KQHGDVVSAIRAGGDETK 227
Query: 471 ITVIPEEID 479
+ V+ E D
Sbjct: 228 LLVVDRETD 236
Score = 33.9 bits (76), Expect = 0.34
Identities = 18/51 (35%), Positives = 26/51 (50%)
Query: 411 GAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMV 461
G YI V P +PAE GL D ++ +NG++V V + + LN V
Sbjct: 36 GQYIRLVEPGSPAEKAGLLAGDRLVEVNGENVEKETHQQVVSRIRAALNAV 86
>gi|30387656 late cornified envelope 1B [Homo sapiens]
Length = 118
Score = 39.7 bits (91), Expect = 0.006
Identities = 28/103 (27%), Positives = 38/103 (36%), Gaps = 14/103 (13%)
Query: 37 CPDRCEPARCPPQ-PEHCEGGRARDACGCCEV-----CGAPEGAACGLQEGPC--GEGLQ 88
CP +C RCPP+ P C CC V CG+ G +CG G C G
Sbjct: 20 CPPKCLTPRCPPKCPPKCP-----PVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSSGGGG 74
Query: 89 CVVPFGVPASATVRRRAQAGLCVCAS-SEPVCGSDANTYANLC 130
C + + R +G C S CG + ++ C
Sbjct: 75 CCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSGQHSGGC 117
>gi|30387652 late cornified envelope 1C [Homo sapiens]
Length = 118
Score = 39.3 bits (90), Expect = 0.008
Identities = 27/103 (26%), Positives = 38/103 (36%), Gaps = 14/103 (13%)
Query: 37 CPDRCEPARCPPQ-PEHCEGGRARDACGCCEV-----CGAPEGAACGLQEGPC--GEGLQ 88
CP +C +CPP+ P C CC V CG+ G +CG G C G
Sbjct: 20 CPPKCPTPKCPPKCPPKCP-----PVSSCCSVSSGGCCGSSSGGSCGSSSGGCCSSGGGG 74
Query: 89 CVVPFGVPASATVRRRAQAGLCVCAS-SEPVCGSDANTYANLC 130
C + + R +G C S CG + ++ C
Sbjct: 75 CCLSHHRRRRSHCHRPQSSGCCSQPSGGSSCCGGGSGQHSGGC 117
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.396
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,800,616
Number of Sequences: 37866
Number of extensions: 934452
Number of successful extensions: 3359
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 45
Number of HSP's successfully gapped in prelim test: 119
Number of HSP's that attempted gapping in prelim test: 3118
Number of HSP's gapped (non-prelim): 317
length of query: 480
length of database: 18,247,518
effective HSP length: 106
effective length of query: 374
effective length of database: 14,233,722
effective search space: 5323412028
effective search space used: 5323412028
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.