Search of human proteins with 4504831

Search of human proteins with 4504831

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|4504831 potassium voltage-gated channel, subfamily H, member
1 isoform 2 [Homo sapiens]
         (962 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|4504831 potassium voltage-gated channel, subfamily H, member ...  1930   0.0  
gi|27437001 potassium voltage-gated channel, subfamily H, member...  1916   0.0  
gi|22024390 potassium voltage-gated channel, subfamily H, member...  1453   0.0  
gi|27886648 potassium voltage-gated channel, subfamily H, member...  1115   0.0  
gi|27886646 potassium voltage-gated channel, subfamily H, member...  1108   0.0  
gi|13540549 potassium voltage-gated channel, subfamily H, member...   553   e-157
gi|27886667 potassium voltage-gated channel, subfamily H, member...   532   e-151
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   513   e-145
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   503   e-142
gi|26051273 voltage-gated potassium channel, subfamily H, member...   473   e-133
gi|27886653 potassium voltage-gated channel, subfamily H, member...   472   e-133
gi|4557729 voltage-gated potassium channel, subfamily H, member ...   471   e-132
gi|27886651 potassium voltage-gated channel, subfamily H, member...   426   e-119
gi|26051271 voltage-gated potassium channel, subfamily H, member...   419   e-117
gi|27886665 potassium voltage-gated channel, subfamily H, member...   325   1e-88
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   178   2e-44
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   173   6e-43
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   173   8e-43
gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...   164   3e-40
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   155   1e-37
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   155   1e-37
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    150   4e-36
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   145   2e-34
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   145   2e-34
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    136   8e-32
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...   113   7e-25
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    113   7e-25
gi|27436984 potassium voltage-gated channel, Shal-related subfam...    44   7e-04
gi|27436986 potassium voltage-gated channel, Shal-related subfam...    44   7e-04
gi|157074214 potassium channel, subfamily U, member 1 [Homo sapi...    44   0.001

>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score = 1930 bits (5001), Expect = 0.0
 Identities = 962/962 (100%), Positives = 962/962 (100%)

Query: 1   MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV 60
           MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV
Sbjct: 1   MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV 60

Query: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120
           MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ
Sbjct: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120

Query: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180
           DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK
Sbjct: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180

Query: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240
           HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS
Sbjct: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240

Query: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300
           FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL
Sbjct: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300

Query: 301 LSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFG 360
           LSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFG
Sbjct: 301 LSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFG 360

Query: 361 LAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKN 420
           LAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKN
Sbjct: 361 LAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKN 420

Query: 421 SVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYA 480
           SVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYA
Sbjct: 421 SVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYA 480

Query: 481 NTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADI 540
           NTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADI
Sbjct: 481 NTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADI 540

Query: 541 CVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLE 600
           CVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLE
Sbjct: 541 CVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLE 600

Query: 601 VIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAF 660
           VIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAF
Sbjct: 601 VIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAF 660

Query: 661 SHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQ 720
           SHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQ
Sbjct: 661 SHSFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQ 720

Query: 721 KEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSG 780
           KEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSG
Sbjct: 721 KEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPVSFQAASTSG 780

Query: 781 VPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTK 840
           VPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTK
Sbjct: 781 VPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTK 840

Query: 841 ASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVL 900
           ASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVL
Sbjct: 841 ASGEATLKKTDSCDSGITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVL 900

Query: 901 EVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFG 960
           EVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFG
Sbjct: 901 EVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQSPESERDIFG 960

Query: 961 AS 962
           AS
Sbjct: 961 AS 962


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score = 1916 bits (4963), Expect = 0.0
 Identities = 962/989 (97%), Positives = 962/989 (97%), Gaps = 27/989 (2%)

Query: 1   MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV 60
           MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV
Sbjct: 1   MTMAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEV 60

Query: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120
           MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ
Sbjct: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120

Query: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180
           DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK
Sbjct: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180

Query: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240
           HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS
Sbjct: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240

Query: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300
           FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL
Sbjct: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300

Query: 301 LSCLPYDVINAFENVDE---------------------------GISSLFSSLKVVRLLR 333
           LSCLPYDVINAFENVDE                           GISSLFSSLKVVRLLR
Sbjct: 301 LSCLPYDVINAFENVDEVSAFMGDPGKIGFADQIPPPLEGRESQGISSLFSSLKVVRLLR 360

Query: 334 LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 393
           LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY
Sbjct: 361 LGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 420

Query: 394 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 453
           QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA
Sbjct: 421 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 480

Query: 454 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 513
           VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI
Sbjct: 481 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 540

Query: 514 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 573
           VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV
Sbjct: 541 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 600

Query: 574 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN 633
           HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN
Sbjct: 601 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCAN 660

Query: 634 VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER 693
           VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER
Sbjct: 661 VRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEEER 720

Query: 694 MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH 753
           MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH
Sbjct: 721 MKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANH 780

Query: 754 SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF 813
           SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF
Sbjct: 781 SLVKASVVTVRESPATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARF 840

Query: 814 KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP 873
           KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP
Sbjct: 841 KDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSDLRLDNVGEARSP 900

Query: 874 QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS 933
           QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS
Sbjct: 901 QDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTS 960

Query: 934 RRSSQSPQELFEISRPQSPESERDIFGAS 962
           RRSSQSPQELFEISRPQSPESERDIFGAS
Sbjct: 961 RRSSQSPQELFEISRPQSPESERDIFGAS 989


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score = 1453 bits (3762), Expect = 0.0
 Identities = 734/995 (73%), Positives = 828/995 (83%), Gaps = 51/995 (5%)

Query: 3   MAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQ 62
           M GG+RGLVAPQNTFLENIVRRS++++F+LGNAQIVDWP+VYSNDGFCKLSGYHRA+VMQ
Sbjct: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60

Query: 63  KSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDK 122
           KSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE +K
Sbjct: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120

Query: 123 VVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHS 182
           VVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHKHS
Sbjct: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHKHS 179

Query: 183 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFK 242
           RLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVSFK
Sbjct: 180 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFK 239

Query: 243 TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLS 302
           T+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDLLS
Sbjct: 240 TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLS 299

Query: 303 CLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLA 362
           CLPYD+INAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHY+EYGAAVLVLLVCVFGL 
Sbjct: 300 CLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLV 359

Query: 363 AHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSV 422
           AHW+ACIWYSIGDYE+ DE T TI+ +SWLYQLA+ IGTPY++N S +G WEGGPSK+S+
Sbjct: 360 AHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS-AGIWEGGPSKDSL 418

Query: 423 YISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANT 482
           Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+VA+MM+GSLLYATIFGNVTTIFQQMYANT
Sbjct: 419 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 478

Query: 483 NRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICV 542
           NRYHEMLN+VRDFLKLYQVPKGLSERVMDYIVSTWSMS+GIDTEKVL ICPKDMRADICV
Sbjct: 479 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 538

Query: 543 HLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI 602
           HLNRKVF EHPAFRLASDGCLRALA+EFQT+HCAPGDLIYHAGESVD+LCFVVSGSLEVI
Sbjct: 539 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 598

Query: 603 QDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSH 662
           QDDEVVAILGKGDVFGD+FWKE TLA +CANVRALTYCDLH+IKR+AL KVL+FYTAF++
Sbjct: 599 QDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAFAN 658

Query: 663 SFSRNLILTYNLRKRIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKE 722
           SFSRNL LT NLRKRI+FRKISDVK+EEEER+++KNE  L +P DHPVR+LFQ+F+QQKE
Sbjct: 659 SFSRNLTLTCNLRKRIIFRKISDVKKEEEERLRQKNEVTLSIPVDHPVRKLFQKFKQQKE 718

Query: 723 ARLAAERGGRDLDDLDVEKGNVLTEHASANH--SLVKASVVTVRESPATPVSFQAASTSG 780
            R      G      D E+  +  E  S  +  S+   SVVTV +      S     TS 
Sbjct: 719 LRNQGSTQG------DPERNQLQVESRSLQNGASITGTSVVTVSQITPIQTSLAYVKTS- 771

Query: 781 VPDHAKLQAPGSECLGPKGGGGD-CAK-----------RKSWARFKDACG----KSEDWN 824
             +  K     +  L P GG    C K            K W R K+  G    K EDWN
Sbjct: 772 --ESLKQNNRDAMELKPNGGADQKCLKVNSPIRMKNGNGKGWLRLKNNMGAHEEKKEDWN 829

Query: 825 KVSKAESMETLPERTKASGEAT------LKKTDSCDSGITKSDLRLDNVGEARSPQDRSP 878
            V+KAESM  L E  K+S          L+KTDSCDSGITKSDLRLD  GEARSP + SP
Sbjct: 830 NVTKAESMGLLSEDPKSSDSENSVTKNPLRKTDSCDSGITKSDLRLDKAGEARSPLEHSP 889

Query: 879 ILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILT------ 932
           I A+ KH FYPIPEQ LQ T+ EV+HELKEDI+ L+ +MT +EKQ++EIL+IL+      
Sbjct: 890 IQADAKHPFYPIPEQALQTTLQEVKHELKEDIQLLSCRMTALEKQVAEILKILSEKSVPQ 949

Query: 933 -SRRSSQSP---------QELFEISRPQSPESERD 957
            S   SQ P         Q++F +SRP+SPES++D
Sbjct: 950 ASSPKSQMPLQVPPQIPCQDIFSVSRPESPESDKD 984


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score = 1115 bits (2883), Expect = 0.0
 Identities = 537/617 (87%), Positives = 585/617 (94%), Gaps = 2/617 (0%)

Query: 61  MQKSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQ 120
           MQKSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE 
Sbjct: 1   MQKSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEH 60

Query: 121 DKVVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHK 180
           +KVVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHK
Sbjct: 61  EKVVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHK 119

Query: 181 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVS 240
           HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVS
Sbjct: 120 HSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVS 179

Query: 241 FKTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDL 300
           FKT+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDL
Sbjct: 180 FKTKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDL 239

Query: 301 LSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFG 360
           LSCLPYD+INAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHY+EYGAAVLVLLVCVFG
Sbjct: 240 LSCLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFG 299

Query: 361 LAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKN 420
           L AHW+ACIWYSIGDYE+ DE T TI+ +SWLYQLA+ IGTPY++N S +G WEGGPSK+
Sbjct: 300 LVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS-AGIWEGGPSKD 358

Query: 421 SVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYA 480
           S+Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+VA+MM+GSLLYATIFGNVTTIFQQMYA
Sbjct: 359 SLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYA 418

Query: 481 NTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADI 540
           NTNRYHEMLN+VRDFLKLYQVPKGLSERVMDYIVSTWSMS+GIDTEKVL ICPKDMRADI
Sbjct: 419 NTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADI 478

Query: 541 CVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLE 600
           CVHLNRKVF EHPAFRLASDGCLRALA+EFQT+HCAPGDLIYHAGESVD+LCFVVSGSLE
Sbjct: 479 CVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLE 538

Query: 601 VIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAF 660
           VIQDDEVVAILGKGDVFGD+FWKE TLA +CANVRALTYCDLH+IKR+AL KVL+FYTAF
Sbjct: 539 VIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKREALLKVLDFYTAF 598

Query: 661 SHSFSRNLILTYNLRKR 677
           ++SFSRNL LT NLRKR
Sbjct: 599 ANSFSRNLTLTCNLRKR 615


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score = 1108 bits (2865), Expect = 0.0
 Identities = 532/609 (87%), Positives = 581/609 (95%), Gaps = 2/609 (0%)

Query: 3   MAGGRRGLVAPQNTFLENIVRRSNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQ 62
           M GG+RGLVAPQNTFLENIVRRS++++F+LGNAQIVDWP+VYSNDGFCKLSGYHRA+VMQ
Sbjct: 1   MPGGKRGLVAPQNTFLENIVRRSSESSFLLGNAQIVDWPVVYSNDGFCKLSGYHRADVMQ 60

Query: 63  KSSTCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDK 122
           KSSTCSFMYGELTDK TIEKVRQTF+NYE N FE+L+YKKNRTPVWF+++IAPIRNE +K
Sbjct: 61  KSSTCSFMYGELTDKKTIEKVRQTFDNYESNCFEVLLYKKNRTPVWFYMQIAPIRNEHEK 120

Query: 123 VVLFLCTFSDITAFKQPIEDDSCKGWGKFARLTRALTSSRGVLQQLAPSVQKGENVHKHS 182
           VVLFLCTF DIT FKQPIEDDS KGW KFARLTRALT+SR VLQQL P + K E VHKHS
Sbjct: 121 VVLFLCTFKDITLFKQPIEDDSTKGWTKFARLTRALTNSRSVLQQLTP-MNKTEVVHKHS 179

Query: 183 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFK 242
           RLAEVLQLGSDILPQYKQEAPKTPPHIILHYC FKTTWDW+ILILTFYTAI+VPYNVSFK
Sbjct: 180 RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCAFKTTWDWVILILTFYTAIMVPYNVSFK 239

Query: 243 TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLS 302
           T+QNN+AWLV+DS+VDVIFLVDIVLNFHTTFVGP GEVISDPKLIRMNYLKTWFVIDLLS
Sbjct: 240 TKQNNIAWLVLDSVVDVIFLVDIVLNFHTTFVGPGGEVISDPKLIRMNYLKTWFVIDLLS 299

Query: 303 CLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLA 362
           CLPYD+INAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHY+EYGAAVLVLLVCVFGL 
Sbjct: 300 CLPYDIINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYLEYGAAVLVLLVCVFGLV 359

Query: 363 AHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSV 422
           AHW+ACIWYSIGDYE+ DE T TI+ +SWLYQLA+ IGTPY++N S +G WEGGPSK+S+
Sbjct: 360 AHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYNTS-AGIWEGGPSKDSL 418

Query: 423 YISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANT 482
           Y+SSLYFTMTSLT++GFGNIAP+TD+EK+F+VA+MM+GSLLYATIFGNVTTIFQQMYANT
Sbjct: 419 YVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATIFGNVTTIFQQMYANT 478

Query: 483 NRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICV 542
           NRYHEMLN+VRDFLKLYQVPKGLSERVMDYIVSTWSMS+GIDTEKVL ICPKDMRADICV
Sbjct: 479 NRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEKVLSICPKDMRADICV 538

Query: 543 HLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVI 602
           HLNRKVF EHPAFRLASDGCLRALA+EFQT+HCAPGDLIYHAGESVD+LCFVVSGSLEVI
Sbjct: 539 HLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGESVDALCFVVSGSLEVI 598

Query: 603 QDDEVVAIL 611
           QDDEVVAIL
Sbjct: 599 QDDEVVAIL 607


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  553 bits (1424), Expect = e-157
 Identities = 297/724 (41%), Positives = 438/724 (60%), Gaps = 67/724 (9%)

Query: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNT+L+ I+R+       F++ NAQ+ +  I+Y NDGFC+L GY R EVMQ+ 
Sbjct: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F+ G  T    + ++ Q     E    +IL Y+K+ +     V + P++NE   V+
Sbjct: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123

Query: 125 LFLCTFSDITAFKQPIEDDSCK-------------------------GWGKFA------- 152
           +F+  F D+          S                           G GK+        
Sbjct: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183

Query: 153 --------RLTRALTSSRGVLQQLAPS--VQKGENVHKHSRLAEVLQLGSDILPQYKQEA 202
                    L +  +SS   ++ +AP   V++ +NV +  ++ +VL LG+D+LP+YK +A
Sbjct: 184 FTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTE--KVTQVLSLGADVLPEYKLQA 241

Query: 203 PKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSF------KTRQNNVAWL----- 251
           P+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F      ++R+   ++      
Sbjct: 242 PRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLT 301

Query: 252 VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINA 311
           VVD IVD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-I 360

Query: 312 FENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWY 371
           F    +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACIWY
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWY 420

Query: 372 SIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTM 431
           +IG+ E    + K      WL  L + +G  Y  NGS       GPS    Y+++LYFT 
Sbjct: 421 AIGNVERPYLEHKI----GWLDSLGVQLGKRY--NGSDPAS---GPSVQDKYVTALYFTF 471

Query: 432 TSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNS 491
           +SLTSVGFGN++P+T+ EK+F++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  
Sbjct: 472 SSLTSVGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLR 531

Query: 492 VRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKE 551
           V++F++ +Q+P  L +R+ +Y    WS + GID   VL+  P+ ++ADIC+HL+R + + 
Sbjct: 532 VKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQH 591

Query: 552 HPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAIL 611
            PAF  A  GCLRALA++F+T H  PGD + H G+ + +L F+  GS+E+++DD VVAIL
Sbjct: 592 CPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAIL 651

Query: 612 GKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILT 671
           GK D+FG+     A   +S A+VRALTYCDLH I+R  L +VL+ Y AF+ SF   L +T
Sbjct: 652 GKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVT 711

Query: 672 YNLR 675
           +NLR
Sbjct: 712 FNLR 715


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  532 bits (1371), Expect = e-151
 Identities = 286/688 (41%), Positives = 438/688 (63%), Gaps = 36/688 (5%)

Query: 8   RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIVD-WPIVYSNDGFCKLSGYHRAEVMQKS 64
           +GL+APQNTFL+ I  R + T  NF+L NAQ+   +PIVY +DGFC+L+G+ R EVMQKS
Sbjct: 5   KGLLAPQNTFLDTIATRFDGTHSNFILANAQVAKGFPIVYCSDGFCELAGFARTEVMQKS 64

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            +C F++G  T++  + ++ ++ E       EI+ YKKN +P W  + I PI+NE+  VV
Sbjct: 65  CSCKFLFGVETNEQLMLQIEKSLEEKTEFKGEIMFYKKNGSPFWCLLDIVPIKNEKGDVV 124

Query: 125 LFLCTFSDITAFKQPI-----EDDSCKGWGKFA-RLTRALTSSRGVLQQLAPSVQKGENV 178
           LFL +F DIT  K  I     ++D  KG  +       A   SR VL  ++  +Q+ E  
Sbjct: 125 LFLASFKDITDTKVKITPEDKKEDKVKGRSRAGTHFDSARRRSRAVLYHISGHLQRREK- 183

Query: 179 HKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYN 238
               ++   + +     P+YK    K    I+LH+  FK  WDW+IL+ TFY A+ VPYN
Sbjct: 184 -NKLKINNNVFVDKPAFPEYKVSDAKKSKFILLHFSTFKAGWDWLILLATFYVAVTVPYN 242

Query: 239 VSF-------KTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY 291
           V F        TR   V+    D  V+++F++DI+LNF TT+V  +G+VI + + I ++Y
Sbjct: 243 VCFIGNDDLSTTRSTTVS----DIAVEILFIIDIILNFRTTYVSKSGQVIFEARSICIHY 298

Query: 292 LKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAV 351
           + TWF+IDL++ LP+D++ AF NV   + SL   LK VRLLRL R+ +KLD Y ++   V
Sbjct: 299 VTTWFIIDLIAALPFDLLYAF-NVT--VVSLVHLLKTVRLLRLLRLLQKLDRYSQHSTIV 355

Query: 352 LVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIR-NNSWLYQLAMDIGTPYQFNGSGS 410
           L LL+ +F L AHWMACIWY IG  E   ED   ++    WL++L   + +PY  N +  
Sbjct: 356 LTLLMSMFALLAHWMACIWYVIGKME--REDNSLLKWEVGWLHELGKRLESPYYGNNT-- 411

Query: 411 GKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGN 470
               GGPS  S YI++LYFT++SLTSVGFGN++ +TD EKIF++  M+IG+L++A +FGN
Sbjct: 412 ---LGGPSIRSAYIAALYFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGN 468

Query: 471 VTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQ 530
           VT I Q+MY+  + YH     ++DF++++ +P+ L +R+++Y  +TWS++ GID+ ++L+
Sbjct: 469 VTAIIQRMYSRWSLYHTRTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLK 528

Query: 531 ICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDS 590
             P ++R+DI +HLN+++  +   F  AS GCLR+L++  +T  CAPG+ +   G+++ +
Sbjct: 529 DFPDELRSDITMHLNKEIL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQA 587

Query: 591 LCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDAL 650
           + FV SGS+EV++D  V+AILGKGD+ G     +  + ++ A+V+ALTYCDL  I    L
Sbjct: 588 IYFVCSGSMEVLKDSMVLAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGL 647

Query: 651 QKVLEFYTAFSHSFSRNL--ILTYNLRK 676
            +VL+ Y  ++H F  ++   LTYNLR+
Sbjct: 648 FEVLDLYPEYAHKFVEDIQHDLTYNLRE 675


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  513 bits (1321), Expect = e-145
 Identities = 288/710 (40%), Positives = 437/710 (61%), Gaps = 53/710 (7%)

Query: 8   RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIVD-WPIVYSNDGFCKLSGYHRAEVMQKS 64
           RGL+APQNTFL+ I  R + T  NFVLGNAQ+   +P+VY +DGFC L+G+ RAEVMQ+ 
Sbjct: 5   RGLLAPQNTFLDTIATRFDGTHSNFVLGNAQVAGLFPVVYCSDGFCDLTGFSRAEVMQRG 64

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
             CSF+YG  T +   +++R+  + ++    E+++Y+K+  P W  + + PI+NE+ +V 
Sbjct: 65  CACSFLYGPDTSELVRQQIRKALDEHKEFKAELILYRKSGLPFWCLLDVIPIKNEKGEVA 124

Query: 125 LFLCTFSDITAFKQPIEDDSCK--GWGKFARLTRALTS--------SRGVLQQLAPSVQK 174
           LFL +  DI+  K     D  K  G G+  R  RA +         SR VL  L+  +QK
Sbjct: 125 LFLVSHKDISETKNRGGPDRWKETGGGR-RRYGRARSKGFNANRRRSRAVLYHLSGHLQK 183

Query: 175 GENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAIL 234
            +   KH +L + +      LP+YK  A +  P I+LH    + TWD  IL+ T Y A+ 
Sbjct: 184 -QPKGKH-KLNKGVFGEKPNLPEYKVAAIRKSPFILLHCGALRATWDGFILLATLYVAVT 241

Query: 235 VPYNVSFKTRQNNVAWL----VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMN 290
           VPY+V   T +   A      V D  V+V+F++DIVLNF TTFV  +G+V+  PK I ++
Sbjct: 242 VPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTTFVSKSGQVVFAPKSICLH 301

Query: 291 YLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSS--LKVVRLLRLGRVARKLDHYIEYG 348
           Y+ TWF++D+++ LP+D+++AF+     ++  F +  LK VRLLRL R+  +LD Y +Y 
Sbjct: 302 YVTTWFLLDVIAALPFDLLHAFK-----VNVYFGAHLLKTVRLLRLLRLLPRLDRYSQYS 356

Query: 349 AAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQF--- 405
           A VL LL+ VF L AHW+AC+W+ IG  EI   +++ +    WL +LA  + TPY     
Sbjct: 357 AVVLTLLMAVFALLAHWVACVWFYIGQREIESSESE-LPEIGWLQELARRLETPYYLVGR 415

Query: 406 ---NGSGSGKWE----------------GGPSKNSVYISSLYFTMTSLTSVGFGNIAPST 446
               G+ SG+ +                GGPS  S YI+SLYF ++SLTSVGFGN++ +T
Sbjct: 416 RPAGGNSSGQSDNCSSSSEANGTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANT 475

Query: 447 DIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLS 506
           D EKIF++  M+IG+L++A +FGNVT I Q+MYA    YH     +RD+++++++PK L 
Sbjct: 476 DTEKIFSICTMLIGALMHAVVFGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLK 535

Query: 507 ERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRAL 566
           +R+++Y  +TW+++ GIDT ++LQ  P ++RADI +HL+++V  + P F  AS GCLRAL
Sbjct: 536 QRMLEYFQATWAVNNGIDTTELLQSLPDELRADIAMHLHKEVL-QLPLFEAASRGCLRAL 594

Query: 567 AMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEAT 626
           ++  +   C PG+ + H G+++ +L FV SGS+EV++   V+AILGKGD+ G    +   
Sbjct: 595 SLALRPAFCTPGEYLIHQGDALQALYFVCSGSMEVLKGGTVLAILGKGDLIGCELPRREQ 654

Query: 627 LAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNL--ILTYNL 674
           + ++ A+V+ LTYC L  ++   L   L  Y  F+  FSR L   L+YNL
Sbjct: 655 VVKANADVKGLTYCVLQCLQLAGLHDSLALYPEFAPRFSRGLRGELSYNL 704


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  503 bits (1296), Expect = e-142
 Identities = 283/700 (40%), Positives = 431/700 (61%), Gaps = 45/700 (6%)

Query: 8   RGLVAPQNTFLENIVRRSNDT--NFVLGNAQIV-DWPIVYSNDGFCKLSGYHRAEVMQKS 64
           +GL+APQNTFL+ I  R + T  NF+L NAQ    +PIVY +DGFC+L+GY R EVMQK+
Sbjct: 5   KGLLAPQNTFLDTIATRFDGTHSNFLLANAQGTRGFPIVYCSDGFCELTGYGRTEVMQKT 64

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            +C F+YG  T +  ++++ +  E ++ +  EI  Y+K+ +  W  + + PI+NE  +VV
Sbjct: 65  CSCRFLYGPETSEPALQRLHKALEGHQEHRAEICFYRKDGSAFWCLLDMMPIKNEMGEVV 124

Query: 125 LFLCTFSDITAFKQP-----------IEDDSCKGWGKFARLTRALTSSRGVLQQLAPSV- 172
           LFL +F DIT    P             ++S    G   +   A   SR VL +L     
Sbjct: 125 LFLFSFKDITQSGSPGLGPQGGRGDSNHENSLGRRGATWKFRSARRRSRTVLHRLTGHFG 184

Query: 173 QKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILILTFYTA 232
           ++G+   K +    V +    + P+YK  +      ++LHY V K  WD +IL+ TFY A
Sbjct: 185 RRGQGGMKANN--NVFEPKPSV-PEYKVASVGGSRCLLLHYSVSKAIWDGLILLATFYVA 241

Query: 233 ILVPYNVSFK----TRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIR 288
           + VPYNV F     T   +   LV D  V+++F++DI+LNF TT+V  +G+VIS P+ I 
Sbjct: 242 VTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYVSQSGQVISAPRSIG 301

Query: 289 MNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYG 348
           ++YL TWF IDL++ LP+D++  F      ++SL   LK VRLLRL R+ +KL+ Y +  
Sbjct: 302 LHYLATWFFIDLIAALPFDLLYIFNIT---VTSLVHLLKTVRLLRLLRLLQKLERYSQCS 358

Query: 349 AAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGS 408
           A VL LL+ VF L AHWMACIWY IG  E+   D   + +  WL++L   +  PY  NGS
Sbjct: 359 AVVLTLLMSVFALLAHWMACIWYVIGRREMEANDP-LLWDIGWLHELGKRLEVPY-VNGS 416

Query: 409 GSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIF 468
                 GGPS+ S YI++LYFT++SLTSVGFGN+  +TD EKIF++  M+IG+L++A +F
Sbjct: 417 -----VGGPSRRSAYIAALYFTLSSLTSVGFGNVCANTDAEKIFSICTMLIGALMHAVVF 471

Query: 469 GNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKV 528
           GNVT I Q+MY+  + YH  +  ++DF++++++P+ L +R+++Y  +TW+++ GID  ++
Sbjct: 472 GNVTAIIQRMYSRRSLYHSRMKDLKDFIRVHRLPRPLKQRMLEYFQTTWAVNSGIDANEL 531

Query: 529 LQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESV 588
           L+  P ++RADI +HLNR++  + P F  AS GCLRAL++  +T  CAPG+ +   G+++
Sbjct: 532 LRDFPDELRADIAMHLNREIL-QLPLFGAASRGCLRALSLHIKTSFCAPGEYLLRRGDAL 590

Query: 589 DSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEAT----------LAQSCANVRALT 638
            +  +V SGSLEV++D+ V+AILGKGD+ G    +             + ++ A+V+ALT
Sbjct: 591 QAHYYVCSGSLEVLRDNMVLAILGKGDLIGADIPEPGQEPGLGADPNFVLKTSADVKALT 650

Query: 639 YCDLHVIKRDALQKVLEFYTAFSHSFSRNL--ILTYNLRK 676
           YC L  +    L +VL  Y  +  +F   L   LT+NLR+
Sbjct: 651 YCGLQQLSSRGLAEVLRLYPEYGAAFRAGLPRDLTFNLRQ 690


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  473 bits (1216), Expect = e-133
 Identities = 244/525 (46%), Positives = 340/525 (64%), Gaps = 32/525 (6%)

Query: 168 LAPSVQKGENVHKHSRLA-----EVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDW 222
           L P  QKG  V +  R++     EVL LG+D+LP+YK +AP+     ILHY  FK  WDW
Sbjct: 14  LRPRAQKGR-VRRAVRISSLVAQEVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDW 72

Query: 223 IILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDIVLNFH 270
           +IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI++NF 
Sbjct: 73  LILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDILINFR 132

Query: 271 TTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVR 330
           TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   LK  R
Sbjct: 133 TTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGLLKTAR 188

Query: 331 LLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNS 390
           LLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACIWY+IG+ E    D++      
Sbjct: 189 LLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI----G 244

Query: 391 WLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEK 450
           WL+ L   IG PY  +G G      GPS    Y+++LYFT +SLTSVGFGN++P+T+ EK
Sbjct: 245 WLHNLGDQIGKPYNSSGLG------GPSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEK 298

Query: 451 IFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVM 510
           IF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L +R+ 
Sbjct: 299 IFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPLRQRLE 358

Query: 511 DYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEF 570
           +Y    WS + GID   VL+  P+ ++ADIC+HLNR + +    FR A+ GCLRALAM+F
Sbjct: 359 EYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRALAMKF 418

Query: 571 QTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQS 630
           +T H  PGD + HAG+ + +L F+  GS+E+++ D VVAILGK D+FG+     A   +S
Sbjct: 419 KTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYARPGKS 478

Query: 631 CANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLR 675
             +VRALTYCDLH I RD L +VL+ Y  FS  F  +L +T+NLR
Sbjct: 479 NGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLR 523


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score =  472 bits (1214), Expect = e-133
 Identities = 243/519 (46%), Positives = 345/519 (66%), Gaps = 22/519 (4%)

Query: 168 LAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILIL 227
           +AP V K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L
Sbjct: 359 IAPKV-KDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLL 417

Query: 228 TFYTAILVPYNVSF--------KTRQNNVAWL---VVDSIVDVIFLVDIVLNFHTTFVGP 276
             YTAI  PY+ +F        K R+   +     VVD IVD++F++DI++NF TT+V  
Sbjct: 418 VIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQ 477

Query: 277 AGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGR 336
             EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL R
Sbjct: 478 NEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVR 536

Query: 337 VARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLA 396
           VARKLD Y EYGAAVL+LL+C+F L AHW+ACIWY+IG+ E      K      WL  L 
Sbjct: 537 VARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKI----GWLDSLG 592

Query: 397 MDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAI 456
             IG  Y  + S SG     PS    Y+++LYFT +SLTSVGFGN++P+T+ EKIF++ +
Sbjct: 593 QQIGKRYNDSDSSSG-----PSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICV 647

Query: 457 MMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVST 516
           M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    
Sbjct: 648 MLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHA 707

Query: 517 WSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCA 576
           W+ + GID   VL+  P+ ++ADIC+HLN+ + +   AFR AS GCLRALAM+F+T H  
Sbjct: 708 WTYTNGIDMNMVLKGFPECLQADICLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAP 767

Query: 577 PGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRA 636
           PGD + H G+ + +L F+  GS+E+++DD VVAILGK D+FG++    A   +S A+VRA
Sbjct: 768 PGDTLVHCGDVLTALYFLSRGSIEILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRA 827

Query: 637 LTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLR 675
           LTYCDLH I+R+ L +VL+ Y  FS  F  NL LT+NLR
Sbjct: 828 LTYCDLHKIQREDLLEVLDMYPEFSDHFLTNLELTFNLR 866



 Score =  100 bits (249), Expect = 7e-21
 Identities = 48/130 (36%), Positives = 76/130 (58%), Gaps = 2/130 (1%)

Query: 7   RRGLVAPQNTFLENIVRRSNDTN--FVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNTFL  I+R+    N  F++ NA++ +  I+Y NDGFC+++G+ R +VMQK 
Sbjct: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F++G  T +  I ++ Q     E    E+  Y KN +       I P++N++   +
Sbjct: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123

Query: 125 LFLCTFSDIT 134
           +F+  F  +T
Sbjct: 124 MFIINFEYVT 133


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score =  471 bits (1213), Expect = e-132
 Identities = 243/530 (45%), Positives = 344/530 (64%), Gaps = 32/530 (6%)

Query: 159 TSSRGVLQQLAPSVQKGENVHKHS-RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFK 217
           TS R ++   AP ++  E  H  + ++ +VL LG+D+LP+YK +AP+     ILHY  FK
Sbjct: 353 TSDREII---APKIK--ERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 407

Query: 218 TTWDWIILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDI 265
             WDW+IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI
Sbjct: 408 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDI 467

Query: 266 VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSS 325
           ++NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   
Sbjct: 468 LINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGL 523

Query: 326 LKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKT 385
           LK  RLLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACIWY+IG+ E    D++ 
Sbjct: 524 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 583

Query: 386 IRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPS 445
                WL+ L   IG PY  +G G      GPS    Y+++LYFT +SLTSVGFGN++P+
Sbjct: 584 ----GWLHNLGDQIGKPYNSSGLG------GPSIKDKYVTALYFTFSSLTSVGFGNVSPN 633

Query: 446 TDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGL 505
           T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L
Sbjct: 634 TNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPL 693

Query: 506 SERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRA 565
            +R+ +Y    WS + GID   VL+  P+ ++ADIC+HLNR + +    FR A+ GCLRA
Sbjct: 694 RQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRA 753

Query: 566 LAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEA 625
           LAM+F+T H  PGD + HAG+ + +L F+  GS+E+++ D VVAILGK D+FG+     A
Sbjct: 754 LAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGKNDIFGEPLNLYA 813

Query: 626 TLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLR 675
              +S  +VRALTYCDLH I RD L +VL+ Y  FS  F  +L +T+NLR
Sbjct: 814 RPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYPEFSDHFWSSLEITFNLR 863



 Score =  106 bits (264), Expect = 1e-22
 Identities = 49/126 (38%), Positives = 75/126 (59%), Gaps = 2/126 (1%)

Query: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNTFL+ I+R+       F++ NA++ +  ++Y NDGFC+L GY RAEVMQ+ 
Sbjct: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F++G  T +    ++ Q     E    EI  Y+K+ +     V + P++NE   V+
Sbjct: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123

Query: 125 LFLCTF 130
           +F+  F
Sbjct: 124 MFILNF 129


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  426 bits (1094), Expect = e-119
 Identities = 255/724 (35%), Positives = 385/724 (53%), Gaps = 120/724 (16%)

Query: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNT+L+ I+R+       F++ NAQ+ +  I+Y NDGFC+L GY R EVMQ+ 
Sbjct: 4   RRGHVAPQNTYLDTIIRKFEGQSRKFLIANAQMENCAIIYCNDGFCELFGYSRVEVMQQP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F+ G  T    + ++ Q     E    +IL Y+K+ +     V + P++NE   V+
Sbjct: 64  CTCDFLTGPNTPSSAVSRLAQALLGAEECKVDILYYRKDASSFRCLVDVVPVKNEDGAVI 123

Query: 125 LFLCTFSDITAFKQPIEDDSCK-------------------------GWGKFA------- 152
           +F+  F D+          S                           G GK+        
Sbjct: 124 MFILNFEDLAQLLAKCSSRSLSQRLLSQSFLGSEGSHGRPGGPGPGTGRGKYRTISQIPQ 183

Query: 153 --------RLTRALTSSRGVLQQLAPS--VQKGENVHKHSRLAEVLQLGSDILPQYKQEA 202
                    L +  +SS   ++ +AP   V++ +NV +  ++ +VL LG+D+LP+YK +A
Sbjct: 184 FTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTE--KVTQVLSLGADVLPEYKLQA 241

Query: 203 PKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSF------KTRQNNVAW-----L 251
           P+     ILHY  FK  WDW+IL+L  YTA+  PY+ +F      ++R+   ++      
Sbjct: 242 PRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLSDQDESRRGACSYTCSPLT 301

Query: 252 VVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINA 311
           VVD IVD++F+VDIV+NF TT+V    EV+S P+ I ++Y K WF+ID+++ +P+D++  
Sbjct: 302 VVDLIVDIMFVVDIVINFRTTYVNTNDEVVSHPRRIAVHYFKGWFLIDMVAAIPFDLL-I 360

Query: 312 FENVDEGISSLFSSLKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWY 371
           F    +  ++L   LK  RLLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACI  
Sbjct: 361 FRTGSDETTTLIGLLKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACI-- 418

Query: 372 SIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTM 431
                                                G G      +   V+   +    
Sbjct: 419 -------------------------------CSLTSVGFGNVSPNTNSEKVFSICVMLIG 447

Query: 432 TSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNS 491
           + + +  FGN+  S  I+++++      G+  Y T                    +ML  
Sbjct: 448 SLMYASIFGNV--SAIIQRLYS------GTARYHT--------------------QMLR- 478

Query: 492 VRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKE 551
           V++F++ +Q+P  L +R+ +Y    WS + GID   VL+  P+ ++ADIC+HL+R + + 
Sbjct: 479 VKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLHRALLQH 538

Query: 552 HPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAIL 611
            PAF  A  GCLRALA++F+T H  PGD + H G+ + +L F+  GS+E+++DD VVAIL
Sbjct: 539 CPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFISRGSIEILRDDVVVAIL 598

Query: 612 GKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILT 671
           GK D+FG+     A   +S A+VRALTYCDLH I+R  L +VL+ Y AF+ SF   L +T
Sbjct: 599 GKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVLDMYPAFAESFWSKLEVT 658

Query: 672 YNLR 675
           +NLR
Sbjct: 659 FNLR 662


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  419 bits (1076), Expect = e-117
 Identities = 213/469 (45%), Positives = 305/469 (65%), Gaps = 32/469 (6%)

Query: 159 TSSRGVLQQLAPSVQKGENVHKHS-RLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFK 217
           TS R ++   AP ++  E  H  + ++ +VL LG+D+LP+YK +AP+     ILHY  FK
Sbjct: 353 TSDREII---APKIK--ERTHNVTEKVTQVLSLGADVLPEYKLQAPRIHRWTILHYSPFK 407

Query: 218 TTWDWIILILTFYTAILVPYNVSFKTRQNNVA------------WLVVDSIVDVIFLVDI 265
             WDW+IL+L  YTA+  PY+ +F  ++                  VVD IVD++F+VDI
Sbjct: 408 AVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDLIVDIMFIVDI 467

Query: 266 VLNFHTTFVGPAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSS 325
           ++NF TT+V    EV+S P  I ++Y K WF+ID+++ +P+D++        G   L   
Sbjct: 468 LINFRTTYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLI----FGSGSEELIGL 523

Query: 326 LKVVRLLRLGRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKT 385
           LK  RLLRL RVARKLD Y EYGAAVL LL+C F L AHW+ACIWY+IG+ E    D++ 
Sbjct: 524 LKTARLLRLVRVARKLDRYSEYGAAVLFLLMCTFALIAHWLACIWYAIGNMEQPHMDSRI 583

Query: 386 IRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPS 445
                WL+ L   IG PY  +G G      GPS    Y+++LYFT +SLTSVGFGN++P+
Sbjct: 584 ----GWLHNLGDQIGKPYNSSGLG------GPSIKDKYVTALYFTFSSLTSVGFGNVSPN 633

Query: 446 TDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGL 505
           T+ EKIF++ +M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  VR+F++ +Q+P  L
Sbjct: 634 TNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVREFIRFHQIPNPL 693

Query: 506 SERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRA 565
            +R+ +Y    WS + GID   VL+  P+ ++ADIC+HLNR + +    FR A+ GCLRA
Sbjct: 694 RQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICLHLNRSLLQHCKPFRGATKGCLRA 753

Query: 566 LAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKG 614
           LAM+F+T H  PGD + HAG+ + +L F+  GS+E+++ D VVAILG G
Sbjct: 754 LAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEILRGDVVVAILGMG 802



 Score =  106 bits (264), Expect = 1e-22
 Identities = 49/126 (38%), Positives = 75/126 (59%), Gaps = 2/126 (1%)

Query: 7   RRGLVAPQNTFLENIVRR--SNDTNFVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNTFL+ I+R+       F++ NA++ +  ++Y NDGFC+L GY RAEVMQ+ 
Sbjct: 4   RRGHVAPQNTFLDTIIRKFEGQSRKFIIANARVENCAVIYCNDGFCELCGYSRAEVMQRP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F++G  T +    ++ Q     E    EI  Y+K+ +     V + P++NE   V+
Sbjct: 64  CTCDFLHGPRTQRRAAAQIAQALLGAEERKVEIAFYRKDGSCFLCLVDVVPVKNEDGAVI 123

Query: 125 LFLCTF 130
           +F+  F
Sbjct: 124 MFILNF 129


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  325 bits (834), Expect = 1e-88
 Identities = 167/372 (44%), Positives = 240/372 (64%), Gaps = 22/372 (5%)

Query: 168 LAPSVQKGENVHKHSRLAEVLQLGSDILPQYKQEAPKTPPHIILHYCVFKTTWDWIILIL 227
           +AP V K    +   ++ +VL LG+D+LP+YK + P+     ILHY  FK  WDW+IL+L
Sbjct: 352 IAPKV-KDRTHNVTEKVTQVLSLGADVLPEYKLQTPRINKFTILHYSPFKAVWDWLILLL 410

Query: 228 TFYTAILVPYNVSF--------KTRQNNVAWL---VVDSIVDVIFLVDIVLNFHTTFVGP 276
             YTAI  PY+ +F        K R+   +     VVD IVD++F++DI++NF TT+V  
Sbjct: 411 VIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIVDIMFIIDILINFRTTYVNQ 470

Query: 277 AGEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGR 336
             EV+SDP  I ++Y K WF+ID+++ +P+D++      DE  ++L   LK  RLLRL R
Sbjct: 471 NEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSDE-TTTLIGLLKTARLLRLVR 529

Query: 337 VARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLA 396
           VARKLD Y EYGAAVL+LL+C+F L AHW+ACIWY+IG+ E      K      WL  L 
Sbjct: 530 VARKLDRYSEYGAAVLMLLMCIFALIAHWLACIWYAIGNVERPYLTDKI----GWLDSLG 585

Query: 397 MDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAI 456
             IG  Y  + S SG     PS    Y+++LYFT +SLTSVGFGN++P+T+ EKIF++ +
Sbjct: 586 QQIGKRYNDSDSSSG-----PSIKDKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICV 640

Query: 457 MMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVST 516
           M+IGSL+YA+IFGNV+ I Q++Y+ T RYH  +  V++F++ +Q+P  L +R+ +Y    
Sbjct: 641 MLIGSLMYASIFGNVSAIIQRLYSGTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHA 700

Query: 517 WSMSRGIDTEKV 528
           W+ + GID   V
Sbjct: 701 WTYTNGIDMNMV 712



 Score =  100 bits (249), Expect = 7e-21
 Identities = 48/130 (36%), Positives = 76/130 (58%), Gaps = 2/130 (1%)

Query: 7   RRGLVAPQNTFLENIVRRSNDTN--FVLGNAQIVDWPIVYSNDGFCKLSGYHRAEVMQKS 64
           RRG VAPQNTFL  I+R+    N  F++ NA++ +  I+Y NDGFC+++G+ R +VMQK 
Sbjct: 4   RRGHVAPQNTFLGTIIRKFEGQNKKFIIANARVQNCAIIYCNDGFCEMTGFSRPDVMQKP 63

Query: 65  STCSFMYGELTDKDTIEKVRQTFENYEMNSFEILMYKKNRTPVWFFVKIAPIRNEQDKVV 124
            TC F++G  T +  I ++ Q     E    E+  Y KN +       I P++N++   +
Sbjct: 64  CTCDFLHGPETKRHDIAQIAQALLGSEERKVEVTYYHKNGSTFICNTHIIPVKNQEGVAM 123

Query: 125 LFLCTFSDIT 134
           +F+  F  +T
Sbjct: 124 MFIINFEYVT 133


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  178 bits (452), Expect = 2e-44
 Identities = 133/502 (26%), Positives = 225/502 (44%), Gaps = 61/502 (12%)

Query: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
           GS    + +QE  KT    I+H Y  F+  WD I+LI+     +++P  ++F T Q    
Sbjct: 115 GSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMVGNLVIIPVGITFFTEQTTTP 174

Query: 250 WLVVDSIVDVIFLVDIVLNFHTTFVG-PAGEVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308
           W++ +   D +FL+D+++NF T  V   + E+I DPK+I+MNYLK+WFV+D +S +P D 
Sbjct: 175 WIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIKMNYLKSWFVVDFISSIPVDY 234

Query: 309 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYIE-----YGAA 350
           I  F  V++G+ S                 L ++RLLRL R+ R +  + E     Y  A
Sbjct: 235 I--FLIVEKGMDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 292

Query: 351 VLVL----LVCVFGLAAHWMACIWYSIGDYEIFDED----TKTIRNNSWLYQLAMDIGTP 402
             V+    L+ +  L  HW  C+ + +   + F  D       + N+SW        G  
Sbjct: 293 SAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVSLNEMVNDSW--------GKQ 344

Query: 403 YQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSL 462
           Y +                    +L+  M+ +  +G+G  AP +  +    +  M++G+ 
Sbjct: 345 YSY--------------------ALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGAT 384

Query: 463 LYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRG 522
            YA   G+ T + Q + ++  +Y E    V  ++  +++P  + +++ DY    +   + 
Sbjct: 385 CYAMFVGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRY-QGKI 443

Query: 523 IDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIY 582
            D E +L      +R +I     RK+    P F  A    + A+  + +     PGD I 
Sbjct: 444 FDEENILNELNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYII 503

Query: 583 HAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDL 642
             G     + F+  G   VI        L  G  FG++     T  +  A+VRA TYC L
Sbjct: 504 REGAVGKKMYFIQHGVAGVITKSSKEMKLTDGSYFGEICL--LTKGRRTASVRADTYCRL 561

Query: 643 HVIKRDALQKVLEFYTAFSHSF 664
           + +  D   +VLE Y     +F
Sbjct: 562 YSLSVDNFNEVLEEYPMMRRAF 583


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  173 bits (439), Expect = 6e-43
 Identities = 129/500 (25%), Positives = 221/500 (44%), Gaps = 57/500 (11%)

Query: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
           GS    + +QE  K+    I+H Y  F+  WD  +L+L     I++P  ++F   +N   
Sbjct: 235 GSQKAVEREQERVKSAGFWIIHPYSDFRFYWDLTMLLLMVGNLIIIPVGITFFKDENTTP 294

Query: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308
           W+V + + D  FL+D+VLNF T  V     E+I DP+ I+M YLK+WF++D +S +P D 
Sbjct: 295 WIVFNVVSDTFFLIDLVLNFRTGIVVEDNTEIILDPQRIKMKYLKSWFMVDFISSIPVDY 354

Query: 309 INAF--ENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYIEYG------AAV 351
           I       +D  +     +L++V         RLLRL R+ R +  + E        A+ 
Sbjct: 355 IFLIVETRIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 414

Query: 352 LVLLVCVFG---LAAHWMACIWYSIGDYEIFDED----TKTIRNNSWLYQLAMDIGTPYQ 404
           +V +V + G   L  HW  C+ + +   + F +D       + NNSW        G  Y 
Sbjct: 415 VVRIVNLIGMMLLLCHWDGCLQFLVPMLQDFPDDCWVSINNMVNNSW--------GKQYS 466

Query: 405 FNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLY 464
           +                    +L+  M+ +  +G+G  AP    +    +  M++G+  Y
Sbjct: 467 Y--------------------ALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSMIVGATCY 506

Query: 465 ATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGID 524
           A   G+ T + Q + ++  +Y E    V  ++  +++P    +R+ DY    +   +  D
Sbjct: 507 AMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY-QGKMFD 565

Query: 525 TEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHA 584
            E +L    + +R +I     RK+    P F  A    + ++  + +     PGD I   
Sbjct: 566 EESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPGDYIIRE 625

Query: 585 GESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHV 644
           G     + F+  G + V+        L  G  FG++     T  +  A+VRA TYC L+ 
Sbjct: 626 GTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICL--LTRGRRTASVRADTYCRLYS 683

Query: 645 IKRDALQKVLEFYTAFSHSF 664
           +  D   +VLE Y     +F
Sbjct: 684 LSVDNFNEVLEEYPMMRRAF 703


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  173 bits (438), Expect = 8e-43
 Identities = 139/566 (24%), Positives = 241/566 (42%), Gaps = 76/566 (13%)

Query: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
           GS    + +QE  K+    I+H Y  F+  WD+ +L+      I++P  ++F   +    
Sbjct: 184 GSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDETTAP 243

Query: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308
           W+V + + D  FL+D+VLNF T  V     E+I DP+ I+  YL+TWFV+D +S +P D 
Sbjct: 244 WIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIPVDY 303

Query: 309 INAFENVDEGISS-------------LFSSLKVVRLLRLGRVARKLDHYIE-----YGAA 350
           I  F  V++GI S                 L ++RLLRL R+ R +  + E     Y  A
Sbjct: 304 I--FLIVEKGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 361

Query: 351 VLVLLVC----VFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFN 406
             V+ +C    +  L  HW  C+ + +   + F         N W+             N
Sbjct: 362 SAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPR-------NCWV-----------SIN 403

Query: 407 GSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYAT 466
           G  +  W      + +Y  +L+  M+ +  +G+G  AP +  +    +  M++G+  YA 
Sbjct: 404 GMVNHSW------SELYSFALFKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAM 457

Query: 467 IFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTE 526
             G+ T + Q + ++  +Y E    V  ++  +++P    +++ DY    +   +  D +
Sbjct: 458 FIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADFRQKIHDYYEHRY-QGKMFDED 516

Query: 527 KVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGE 586
            +L      +R +I     RK+    P F  A    + A+  + +     PGD I   G 
Sbjct: 517 SILGELNGPLREEIVNFNCRKLVASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGT 576

Query: 587 SVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDLHVIK 646
               + F+  G + V+        L  G  FG++     T  +  A+VRA TYC L+ + 
Sbjct: 577 IGKKMYFIQHGVVSVLTKGNKEMKLSDGSYFGEICL--LTRGRRTASVRADTYCRLYSLS 634

Query: 647 RDALQKVLEFYTAFSHSF------------SRNLIL-----------TYNLRKRIVFRKI 683
            D   +VLE Y     +F             +N IL            +N ++  + ++I
Sbjct: 635 VDNFNEVLEEYPMMRRAFETVAIDRLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEI 694

Query: 684 SDVKREEEERMKRKNEAPLILPPDHP 709
               RE  ++ +      L  PP  P
Sbjct: 695 VKYDREMVQQAELGQRVGLFPPPPPP 720


>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score =  164 bits (416), Expect = 3e-40
 Identities = 133/526 (25%), Positives = 231/526 (43%), Gaps = 62/526 (11%)

Query: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249
           GS    + +QE  K+    I+H Y  F+  WD I+L+L     I++P  ++F   +N+  
Sbjct: 66  GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 125

Query: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYD- 307
           W+V + + D  FL+D+VLNF T  V   G E++  P+ IR  YL+TWF++DL+S +P D 
Sbjct: 126 WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY 185

Query: 308 ---VINAFENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYIE-----YGAA 350
              V+     +D  +     +L++V         RLLRL R+ R +  + E     Y  A
Sbjct: 186 IFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 245

Query: 351 VLVL----LVCVFGLAAHWMACIWYSIGDYEIFDED----TKTIRNNSWLYQLAMDIGTP 402
             V+    L+ +  L  HW  C+ + +   + F  D       + N+SW  Q        
Sbjct: 246 SAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQ-------- 297

Query: 403 YQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSL 462
                               Y  +L+  M+ +  +G+G  AP    +    +  M++G+ 
Sbjct: 298 --------------------YSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGAT 337

Query: 463 LYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRG 522
            YA   G+ T + Q + ++  +Y E    V  ++  +++P    +R+ +Y    +   + 
Sbjct: 338 CYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QGKM 396

Query: 523 IDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIY 582
            D E +L    + +R +I     R +    P F  A    + A+  + +     PGDL+ 
Sbjct: 397 FDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVV 456

Query: 583 HAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDL 642
             G     + F+  G L V+        L  G  FG++     T  +  A+VRA TYC L
Sbjct: 457 REGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICL--LTRGRRTASVRADTYCRL 514

Query: 643 HVIKRDALQKVLEFYTAFSHSF---SRNLILTYNLRKRIVFRKISD 685
           + +  D    VLE +     +F   + + +L    +  I+ RK S+
Sbjct: 515 YSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSE 560


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  155 bits (393), Expect = 1e-37
 Identities = 132/515 (25%), Positives = 239/515 (46%), Gaps = 61/515 (11%)

Query: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256
           K++A    P   L+Y      W   I +  FY   L+     F   Q+   + WLV+D  
Sbjct: 137 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191

Query: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315
            DV++++D+++   T F+   G ++SD   +  +Y   T F +D+LS +P D+       
Sbjct: 192 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL---- 246

Query: 316 DEGISSLFSSLKVVRLLRLGRVARKLD---------HYIEYGAAVLVLLVCVFGLAAHWM 366
              + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW 
Sbjct: 247 --KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWN 299

Query: 367 ACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISS 426
           ACI+++I  +  F  D       SW+Y    +I  P   +G  S K          YI S
Sbjct: 300 ACIYFAISKFIGFGTD-------SWVYP---NISIPE--HGRLSRK----------YIYS 337

Query: 427 LYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYH 486
           LY++  +LT++G     P  D E +F V   ++G L++ATI GNV ++   M A+   + 
Sbjct: 338 LYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 396

Query: 487 EMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNR 546
             ++S++ +++  +V K L  RV+ +    W+  + +D ++VL+  P  ++A+I ++++ 
Sbjct: 397 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 456

Query: 547 KVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDE 606
              K+   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD 
Sbjct: 457 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 516

Query: 607 VV--AILGKGDVFGDVFWKEATLAQS----CANVRALTYCDLHVIKRDALQKVLEFYTAF 660
           V    +L  G  FG++       ++S     AN+R++ Y DL  + +D L + L  Y   
Sbjct: 517 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 576

Query: 661 SHSF---SRNLILTYNLRKRIVFRKISDVKREEEE 692
             +     R +++  NL    + R  +D K  EE+
Sbjct: 577 KKALEEKGRQILMKDNLIDEELARAGADPKDLEEK 611


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  155 bits (393), Expect = 1e-37
 Identities = 132/515 (25%), Positives = 239/515 (46%), Gaps = 61/515 (11%)

Query: 199 KQEAPKTPPHIILHYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSI 256
           K++A    P   L+Y      W   I +  FY   L+     F   Q+   + WLV+D  
Sbjct: 155 KKDAIVVDPSSNLYY-----RWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 209

Query: 257 VDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENV 315
            DV++++D+++   T F+   G ++SD   +  +Y   T F +D+LS +P D+       
Sbjct: 210 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL---- 264

Query: 316 DEGISSLFSSLKVVRLLRLGRVARKLD---------HYIEYGAAVLVLLVCVFGLAAHWM 366
              + + +  ++  RLL+  R+    D         +    G  VL +L+ +     HW 
Sbjct: 265 --KVGTNYPEVRFNRLLKFSRLFEFFDRTETRTNYPNMFRIGNLVLYILIII-----HWN 317

Query: 367 ACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISS 426
           ACI+++I  +  F  D       SW+Y    +I  P   +G  S K          YI S
Sbjct: 318 ACIYFAISKFIGFGTD-------SWVYP---NISIPE--HGRLSRK----------YIYS 355

Query: 427 LYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYH 486
           LY++  +LT++G     P  D E +F V   ++G L++ATI GNV ++   M A+   + 
Sbjct: 356 LYWSTLTLTTIG-ETPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQ 414

Query: 487 EMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNR 546
             ++S++ +++  +V K L  RV+ +    W+  + +D ++VL+  P  ++A+I ++++ 
Sbjct: 415 AKIDSIKQYMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHL 474

Query: 547 KVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDE 606
              K+   F+    G L  L ++ +    +PGD I   G+    +  +  G L V+ DD 
Sbjct: 475 DTLKKVRIFQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDG 534

Query: 607 VV--AILGKGDVFGDVFWKEATLAQS----CANVRALTYCDLHVIKRDALQKVLEFYTAF 660
           V    +L  G  FG++       ++S     AN+R++ Y DL  + +D L + L  Y   
Sbjct: 535 VTQFVVLSDGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEA 594

Query: 661 SHSF---SRNLILTYNLRKRIVFRKISDVKREEEE 692
             +     R +++  NL    + R  +D K  EE+
Sbjct: 595 KKALEEKGRQILMKDNLIDEELARAGADPKDLEEK 629


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  150 bits (380), Expect = 4e-36
 Identities = 117/456 (25%), Positives = 209/456 (45%), Gaps = 42/456 (9%)

Query: 212 HYCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSIVDVIFLVDIVLNF 269
           +YC     W ++I +   Y   L+     F   Q    + WLV+D + DV+++ D+ +  
Sbjct: 140 YYC-----WLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADLFIRL 194

Query: 270 HTTFVGPAGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEGISSLFSSLKV 328
            T F+   G ++ D K +R NY+ T  F +D+ S +P D+I    ++          L  
Sbjct: 195 RTGFL-EQGLLVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPEVRFNRLLHF 253

Query: 329 VRLLRL-GRVARKLDHYIEYGAAVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIR 387
            R+     R   + ++   +  + LVL + V     HW ACI+Y+I     F  DT    
Sbjct: 254 ARMFEFFDRTETRTNYPNIFRISNLVLYILVI---IHWNACIYYAISKSIGFGVDT---- 306

Query: 388 NNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTD 447
              W+Y    D    Y                   YI  LY++  +LT++G     P  D
Sbjct: 307 ---WVYPNITDPEYGYLARE---------------YIYCLYWSTLTLTTIG-ETPPPVKD 347

Query: 448 IEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSE 507
            E +F +   +IG L++ATI GNV ++   M A    +   +++V+ +++  +V KG+  
Sbjct: 348 EEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVSKGMEA 407

Query: 508 RVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALA 567
           +V+ +    W+  + +D  ++L+  P  +RA+I ++++    K+   F     G L  L 
Sbjct: 408 KVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGLLVELV 467

Query: 568 MEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVF---W 622
           ++ +    +PGD I   G+    +  +  G L V+ DD V   A+L  G  FG++     
Sbjct: 468 LKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEISILNI 527

Query: 623 KEATLA-QSCANVRALTYCDLHVIKRDALQKVLEFY 657
           K + +  +  AN+R+L Y DL  + +D L + +  Y
Sbjct: 528 KGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEY 563


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  145 bits (365), Expect = 2e-34
 Identities = 122/521 (23%), Positives = 231/521 (44%), Gaps = 44/521 (8%)

Query: 220 WDWIILILTFYTAILVPYNVSFKTRQNNVA--WLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
           W + I +   Y   +V     F   Q++    WL++D + D+++L+D+ +   T ++   
Sbjct: 237 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 296

Query: 278 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRV 337
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 297 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 350

Query: 338 A---RKLDHYIEYGAAVLVL-LVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 393
               ++ +    Y     +  LV    +  HW AC++YSI     F  DT       W+Y
Sbjct: 351 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDT-------WVY 403

Query: 394 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 453
               DI  P           E G      Y+ SLY++  +LT++G     P  D E +F 
Sbjct: 404 P---DINDP-----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFV 447

Query: 454 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 513
           V   +IG L++ATI GN+ ++   M A    +   +++++ ++    V K + +RV+ + 
Sbjct: 448 VVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWF 507

Query: 514 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 573
              W+  + +D ++VL+  P  +RA+I ++++    K+   F     G L  L ++ Q  
Sbjct: 508 DYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQ 567

Query: 574 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVFWKEATLAQS- 630
             +PGD I   G+    +  +  G L V+ DD V    +L  G  FG++       +++ 
Sbjct: 568 VYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAG 627

Query: 631 ---CANVRALTYCDLHVIKRDALQKVLEFY---TAFSHSFSRNLILTYNLRKRIVFRKIS 684
               AN++++ Y DL  + +D L + L  Y           + +++   L    +    S
Sbjct: 628 NRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGS 687

Query: 685 DVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARL 725
           D K  EE+  + +    L+      +   ++  +Q+ + RL
Sbjct: 688 DPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRL 728


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  145 bits (365), Expect = 2e-34
 Identities = 122/521 (23%), Positives = 231/521 (44%), Gaps = 44/521 (8%)

Query: 220 WDWIILILTFYTAILVPYNVSFKTRQNNVA--WLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
           W + I +   Y   +V     F   Q++    WL++D + D+++L+D+ +   T ++   
Sbjct: 168 WLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMFVRTRTGYLEQG 227

Query: 278 GEVISDPKLIRMNYLKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGRV 337
             V  + KLI        F +D+LS +P D++         +   +  +++ RLLR  R+
Sbjct: 228 LLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYF------KLGWNYPEIRLNRLLRFSRM 281

Query: 338 A---RKLDHYIEYGAAVLVL-LVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLY 393
               ++ +    Y     +  LV    +  HW AC++YSI     F  DT       W+Y
Sbjct: 282 FEFFQRTETRTNYPNIFRISNLVMYIVIIIHWNACVFYSISKAIGFGNDT-------WVY 334

Query: 394 QLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFA 453
               DI  P           E G      Y+ SLY++  +LT++G     P  D E +F 
Sbjct: 335 P---DINDP-----------EFGRLARK-YVYSLYWSTLTLTTIG-ETPPPVRDSEYVFV 378

Query: 454 VAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYI 513
           V   +IG L++ATI GN+ ++   M A    +   +++++ ++    V K + +RV+ + 
Sbjct: 379 VVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDMEKRVIKWF 438

Query: 514 VSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTV 573
              W+  + +D ++VL+  P  +RA+I ++++    K+   F     G L  L ++ Q  
Sbjct: 439 DYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVELVLKLQPQ 498

Query: 574 HCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDVFWKEATLAQS- 630
             +PGD I   G+    +  +  G L V+ DD V    +L  G  FG++       +++ 
Sbjct: 499 VYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISILNIKGSKAG 558

Query: 631 ---CANVRALTYCDLHVIKRDALQKVLEFY---TAFSHSFSRNLILTYNLRKRIVFRKIS 684
               AN++++ Y DL  + +D L + L  Y           + +++   L    +    S
Sbjct: 559 NRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLDLNIANAGS 618

Query: 685 DVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARL 725
           D K  EE+  + +    L+      +   ++  +Q+ + RL
Sbjct: 619 DPKDLEEKVTRMEGSVDLLQTRFARILAEYESMQQKLKQRL 659


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  136 bits (343), Expect = 8e-32
 Identities = 111/452 (24%), Positives = 205/452 (45%), Gaps = 45/452 (9%)

Query: 220 WDWIILILTFYTAILVPYNVSFKTRQNN--VAWLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
           W   ++    Y  I++     F   Q+   VAWLV+D   D+++L+D+V+ FHT F+   
Sbjct: 37  WLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMVVRFHTGFL-EQ 95

Query: 278 GEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGR 336
           G ++ D   I   Y++TW F +DL S +P DV+         +     +L++ R LR  R
Sbjct: 96  GILVVDKGRISSRYVRTWSFFLDLASLMPTDVVYV------RLGPHTPTLRLNRFLRAPR 149

Query: 337 VARKLDHYIEYGA-----AVLVLLVCVFGLAAHWMACIWYSIGDYEIFDEDTKTIRNNSW 391
           +    D      A      +  L++ +F +  HW +C+++++  Y  F  D       +W
Sbjct: 150 LFEAFDRTETRTAYPNAFRIAKLMLYIF-VVIHWNSCLYFALSRYLGFGRD-------AW 201

Query: 392 LYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKI 451
           +Y    D   P            G       Y+ S YF+   LT+VG     P+ + E +
Sbjct: 202 VYP---DPAQP------------GFERLRRQYLYSFYFSTLILTTVG-DTPPPAREEEYL 245

Query: 452 FAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMD 511
           F V   ++  + +ATI G+++++   M      ++     V+ ++KL  V + L  RV+D
Sbjct: 246 FMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNRKLERRVID 305

Query: 512 YIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQ 571
           +        +  +   +LQ  P+ +RA++ V ++         F+      L  L ++ Q
Sbjct: 306 WYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLLEELVLKLQ 365

Query: 572 TVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVV--AILGKGDVFGDV----FWKEA 625
               +PG+ +   G+    +  +  G L V+ DD +   A+LG G  FG++         
Sbjct: 366 PQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEISIINIKGNM 425

Query: 626 TLAQSCANVRALTYCDLHVIKRDALQKVLEFY 657
           +  +  AN+++L Y DL  + ++ L++VL  Y
Sbjct: 426 SGNRRTANIKSLGYSDLFCLSKEDLREVLSEY 457


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score =  113 bits (283), Expect = 7e-25
 Identities = 117/514 (22%), Positives = 211/514 (41%), Gaps = 82/514 (15%)

Query: 220  WDWIILILTFYTAILVPYNVSF--KTRQNNVAWLVVDSIVDVIFLVDI-VLNFHTTFVGP 276
            W + +++   +   L+P   +F  +T  N   WL++D + D+I+ +DI V      FV  
Sbjct: 659  WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITVFQTRLQFVR- 717

Query: 277  AGEVISDPKLIRMNYLKTW-FVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLG 335
             G++I+D K +R NYLK+  F +DLLS LP D    F  +  G++ L    + ++ +   
Sbjct: 718  GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLD----FLYLKVGVNPLLRLPRCLKYMAFF 773

Query: 336  RVARKLDHYIEYGAAVLVLLVCVFGL-AAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQ 394
                +L+  +       V+    + L + H  +C++Y    Y+                 
Sbjct: 774  EFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYWASAYQ----------------- 816

Query: 395  LAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAV 454
                        G GS  W      NS YI   YF + +L ++G G   P T  E +F +
Sbjct: 817  ------------GLGSTHWVYDGVGNS-YIRCYYFAVKTLITIG-GLPDPKTLFEIVFQL 862

Query: 455  AIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIV 514
                 G   ++ + G +  +     A    Y   ++S   ++  Y++PK +  RV  +  
Sbjct: 863  LNYFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYE 922

Query: 515  STWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVH 574
             TW     +D  +++   P  MR D+ + +N  +  +   F+      +  +    ++V 
Sbjct: 923  YTWHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVV 982

Query: 575  CAPGDLIYHAGESVDSLCFVVSGSLEVI---QDDEVVAILGKGDVFGDVFWKEATLA--- 628
              P D +   GE    +  + +G ++V+       V+  L  G VFG++    + LA   
Sbjct: 983  YLPNDYVCKKGEIGREMYIIQAGQVQVLGGPDGKSVLVTLKAGSVFGEI----SLLAVGG 1038

Query: 629  --QSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDV 686
              +  ANV A  + +L ++ +  L ++L  Y       S+ L+                 
Sbjct: 1039 GNRRTANVVAHGFTNLFILDKKDLNEILVHYPE-----SQKLL----------------- 1076

Query: 687  KREEEERMKRKNEAP------LILPPDHPVRRLF 714
             R++  RM R N  P      LILPP     +LF
Sbjct: 1077 -RKKARRMLRSNNKPKEEKSVLILPPRAGTPKLF 1109


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score =  113 bits (283), Expect = 7e-25
 Identities = 103/504 (20%), Positives = 212/504 (42%), Gaps = 57/504 (11%)

Query: 222 WIILILTFYT--AILVPYNVSF--KTRQNNVAWLVVDSIVDVIFLVDIVLNFHTTFVGPA 277
           W++L+   Y      +P  + F  +T  N   WL+ D I D+I+L D++           
Sbjct: 221 WLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLIADIICDIIYLYDMLFIQPRLQFVRG 280

Query: 278 GEVISDPKLIRMNY-LKTWFVIDLLSCLPYDVINAFENVDEGISSLFSSLKVVRLLRLGR 336
           G++I D   +R +Y   T F +D+ S +P+D+   F     G + +F + ++++      
Sbjct: 281 GDIIVDSNELRKHYRTSTKFQLDVASIIPFDICYLF----FGFNPMFRANRMLKYTSFFE 336

Query: 337 VARKLDHYIEYGAAVLVLLVCVFGL-AAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQL 395
               L+  ++      V+    + L   H  AC++Y   +YE        I    W+Y  
Sbjct: 337 FNHHLESIMDKAYIYRVIRTTGYLLFILHINACVYYWASNYE-------GIGTTRWVY-- 387

Query: 396 AMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVA 455
                     +G G           + Y+   Y+ + +L ++G G   P T  E +F + 
Sbjct: 388 ----------DGEG-----------NEYLRCYYWAVRTLITIG-GLPEPQTLFEIVFQLL 425

Query: 456 IMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVS 515
               G  +++++ G +  +     AN N +   ++    ++  Y +PK + +RV  +   
Sbjct: 426 NFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDTIAYMNNYSIPKLVQKRVRTWYEY 485

Query: 516 TWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHC 575
           TW   R +D   +L+  P  ++  + + +N  +  +   F+      +  + +  ++V  
Sbjct: 486 TWDSQRMLDESDLLKTLPTTVQLALAIDVNFSIISKVDLFKGCDTQMIYDMLLRLKSVLY 545

Query: 576 APGDLIYHAGESVDSLCFVVSGSLEVI---QDDEVVAILGKGDVFGDVFWKEATLA-QSC 631
            PGD +   GE    +  +  G ++V+      +V+  L  G VFG++    A    +  
Sbjct: 546 LPGDFVCKKGEIGKEMYIIKHGEVQVLGGPDGTKVLVTLKAGSVFGEISLLAAGGGNRRT 605

Query: 632 ANVRALTYCDLHVIKRDALQKVLEFYTAFSHSFSRNLILTYNLRKRIVFRKISDVKREEE 691
           ANV A  + +L  + +  LQ++L  Y       S  +++    + R++ ++    K +  
Sbjct: 606 ANVVAHGFANLLTLDKKTLQEILVHYPD-----SERILMK---KARVLLKQ----KAKTA 653

Query: 692 ERMKRKNEAPLILPPDHPVRRLFQ 715
           E    + +  L+ PP     +LF+
Sbjct: 654 EATPPRKDLALLFPPKEETPKLFK 677


>gi|27436984 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 1 [Homo sapiens]
          Length = 655

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 50/245 (20%), Positives = 103/245 (42%), Gaps = 59/245 (24%)

Query: 247 NVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWF-VIDLLSCLP 305
           +VA+  +D+   +IF V+ +L     F  P+          R  ++++   +ID+++ +P
Sbjct: 223 SVAFFCLDTACVMIFTVEYLLRL---FAAPS----------RYRFIRSVMSIIDVVAIMP 269

Query: 306 YDVINAFENVDEGISSLFSSLKVVRLLRLGRVARK------LDHYIEYGAAVLVLLVCVF 359
           Y +     N +E +S  F +L+V R+ R+ + +R       L + ++  A+ L  L+   
Sbjct: 270 YYIGLVMTN-NEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSL 328

Query: 360 GLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSK 419
            +A    A + +                               Y   GS + K+   P+ 
Sbjct: 329 TMAIIIFATVMF-------------------------------YAEKGSSASKFTSIPA- 356

Query: 420 NSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMY 479
                 S ++T+ ++T++G+G++ P T   KIF     + G L+ A     + + F ++Y
Sbjct: 357 ------SFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIY 410

Query: 480 ANTNR 484
               R
Sbjct: 411 HQNQR 415


>gi|27436986 potassium voltage-gated channel, Shal-related
           subfamily, member 3 isoform 2 [Homo sapiens]
          Length = 636

 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 50/245 (20%), Positives = 103/245 (42%), Gaps = 59/245 (24%)

Query: 247 NVAWLVVDSIVDVIFLVDIVLNFHTTFVGPAGEVISDPKLIRMNYLKTWF-VIDLLSCLP 305
           +VA+  +D+   +IF V+ +L     F  P+          R  ++++   +ID+++ +P
Sbjct: 223 SVAFFCLDTACVMIFTVEYLLRL---FAAPS----------RYRFIRSVMSIIDVVAIMP 269

Query: 306 YDVINAFENVDEGISSLFSSLKVVRLLRLGRVARK------LDHYIEYGAAVLVLLVCVF 359
           Y +     N +E +S  F +L+V R+ R+ + +R       L + ++  A+ L  L+   
Sbjct: 270 YYIGLVMTN-NEDVSGAFVTLRVFRVFRIFKFSRHSQGLRILGYTLKSCASELGFLLFSL 328

Query: 360 GLAAHWMACIWYSIGDYEIFDEDTKTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSK 419
            +A    A + +                               Y   GS + K+   P+ 
Sbjct: 329 TMAIIIFATVMF-------------------------------YAEKGSSASKFTSIPA- 356

Query: 420 NSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMY 479
                 S ++T+ ++T++G+G++ P T   KIF     + G L+ A     + + F ++Y
Sbjct: 357 ------SFWYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIY 410

Query: 480 ANTNR 484
               R
Sbjct: 411 HQNQR 415


>gi|157074214 potassium channel, subfamily U, member 1 [Homo
           sapiens]
          Length = 1149

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 23/78 (29%), Positives = 41/78 (52%), Gaps = 4/78 (5%)

Query: 408 SGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSLLYATI 467
           SG    +G  S+N  Y  S+Y  M + ++VGFG++   T + + F +    +GSL+   +
Sbjct: 248 SGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTF-IMFFTLGSLI---L 303

Query: 468 FGNVTTIFQQMYANTNRY 485
           F N      +++AN  +Y
Sbjct: 304 FANYIPEMVELFANKRKY 321


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 34,995,861
Number of Sequences: 37866
Number of extensions: 1527684
Number of successful extensions: 4909
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 33
Number of HSP's that attempted gapping in prelim test: 4690
Number of HSP's gapped (non-prelim): 150
length of query: 962
length of database: 18,247,518
effective HSP length: 112
effective length of query: 850
effective length of database: 14,006,526
effective search space: 11905547100
effective search space used: 11905547100
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.