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Search of human proteins with 4504615
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4504615 insulin-like growth factor binding protein 1
precursor [Homo sapiens]
(259 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4504615 insulin-like growth factor binding protein 1 precurso... 548 e-156
gi|55925576 insulin-like growth factor binding protein 2, 36kDa ... 151 6e-37
gi|62243290 insulin-like growth factor binding protein 4 precurs... 144 6e-35
gi|10834982 insulin-like growth factor binding protein 5 [Homo s... 133 2e-31
gi|62243068 insulin-like growth factor binding protein 3 isoform... 124 1e-28
gi|62243248 insulin-like growth factor binding protein 3 isoform... 121 5e-28
gi|11321593 insulin-like growth factor binding protein 6 [Homo s... 95 5e-20
gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens] 55 5e-08
gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens] 47 1e-05
gi|4504619 insulin-like growth factor binding protein 7 [Homo sa... 47 2e-05
gi|55770862 thyroglobulin [Homo sapiens] 45 5e-05
gi|4759164 sparc/osteonectin, cwcv and kazal-like domains proteo... 45 8e-05
gi|78190498 secreted modular calcium-binding protein 1 isoform 1... 44 2e-04
gi|11545873 secreted modular calcium-binding protein 1 isoform 2... 44 2e-04
gi|7662036 sparc/osteonectin, cwcv and kazal-like domains proteo... 43 2e-04
gi|56090548 insulin-like growth factor binding protein-like 1 [H... 43 2e-04
gi|93141003 testican 3 isoform 1 [Homo sapiens] 43 3e-04
gi|93141001 testican 3 isoform 2 [Homo sapiens] 43 3e-04
gi|68448544 CD74 antigen isoform a [Homo sapiens] 42 4e-04
gi|18491000 WNT1 inducible signaling pathway protein 1 isoform 2... 41 0.001
gi|144953895 nidogen 2 precursor [Homo sapiens] 40 0.002
gi|208022668 endothelial cell-specific molecule 1 isoform b prec... 35 0.050
gi|4507923 WNT1 inducible signaling pathway protein 2 precursor ... 35 0.050
gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens] 35 0.050
gi|4503123 connective tissue growth factor [Homo sapiens] 35 0.065
gi|5901946 endothelial cell-specific molecule 1 isoform a precur... 35 0.085
gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens] 33 0.25
gi|115298674 nidogen 1 precursor [Homo sapiens] 33 0.25
gi|4507921 WNT1 inducible signaling pathway protein 1 isoform 1 ... 33 0.32
gi|30387656 late cornified envelope 1B [Homo sapiens] 32 0.42
>gi|4504615 insulin-like growth factor binding protein 1 precursor
[Homo sapiens]
Length = 259
Score = 548 bits (1413), Expect = e-156
Identities = 259/259 (100%), Positives = 259/259 (100%)
Query: 1 MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCC 60
MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCC
Sbjct: 1 MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCC 60
Query: 61 PMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGS 120
PMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGS
Sbjct: 61 PMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGS 120
Query: 121 PESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIEL 180
PESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIEL
Sbjct: 121 PESPESTEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIEL 180
Query: 181 YRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIP 240
YRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIP
Sbjct: 181 YRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIP 240
Query: 241 GSPEIRGDPNCQIYFNVQN 259
GSPEIRGDPNCQIYFNVQN
Sbjct: 241 GSPEIRGDPNCQIYFNVQN 259
>gi|55925576 insulin-like growth factor binding protein 2, 36kDa
[Homo sapiens]
Length = 328
Score = 151 bits (381), Expect = 6e-37
Identities = 93/294 (31%), Positives = 146/294 (49%), Gaps = 46/294 (15%)
Query: 11 LVLLLLTVQVG---VTAGAPWQCAPCSAEKLALC--PPVSAS-------------CSEVT 52
L+LLLL G A ++C PC+ E+LA C PPV+ C+E+
Sbjct: 23 LLLLLLGASGGGGGARAEVLFRCPPCTPERLAACGPPPVAPPAAVAAVAGGARMPCAELV 82
Query: 53 RSAGCGCCPMCALPLGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASA 112
R GCGCC +CA G ACGV T RC +GL C PG + PL AL G+G C + DA
Sbjct: 83 REPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGSELPLQALVMGEGTCEKRRDAEY 142
Query: 113 PHAAEAGSPESPESTE--ITEEELLDNFHLMA-----------PSEEDHSILWDAISTYD 159
+ E + + +E + E + +++ ++ ++ + ++
Sbjct: 143 GASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQH 202
Query: 160 ---GSKALHVTNIKKWKE--------PCRIELYRVVE--SLAKAQETSG--EEISKFYLP 204
G H +++ K+ PC+ EL +V+E S + + G E + ++P
Sbjct: 203 RQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIP 262
Query: 205 NCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQ 258
NC+K+G Y+ +QC+ S++G+ G CWCV P GK I G+P IRGDP C +++N Q
Sbjct: 263 NCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQ 316
>gi|62243290 insulin-like growth factor binding protein 4 precursor
[Homo sapiens]
Length = 258
Score = 144 bits (364), Expect = 6e-35
Identities = 86/249 (34%), Positives = 126/249 (50%), Gaps = 20/249 (8%)
Query: 14 LLLTVQVGVTAG-APWQCAPCSAEKLALC-PPVSASCSEVTRSAGCGCCPMCALPLGAAC 71
LLL G + G C PCS EKLA C PPV C E+ R GCGCC CAL LG C
Sbjct: 10 LLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVG--CEELVREPGCGCCATCALGLGMPC 67
Query: 72 GVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPESTEITE 131
GV T RC GL C G ++PLH L GQG C++ ++ A ES + ++ E
Sbjct: 68 GVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEA-------IQESLQPSDKDE 120
Query: 132 EELLDNFHLMAPSEEDHSILWDAISTYDGSKA---LHVTNIKKW------KEPCRIELYR 182
+ +N + + + D S + + V + + C+ EL+R
Sbjct: 121 GDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHR 180
Query: 183 VVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGS 242
+E LA +Q + E++ +PNC++NG +H +QC ++DG+ G CWCV G ++PG
Sbjct: 181 ALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGG 240
Query: 243 PEIRGDPNC 251
E +G+ +C
Sbjct: 241 LEPKGELDC 249
>gi|10834982 insulin-like growth factor binding protein 5 [Homo
sapiens]
Length = 272
Score = 133 bits (334), Expect = 2e-31
Identities = 83/265 (31%), Positives = 124/265 (46%), Gaps = 27/265 (10%)
Query: 12 VLLLLTVQVGV--TAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGA 69
VLLLL G + G+ C PC + L++CPP C E+ + GCGCC CAL G
Sbjct: 7 VLLLLAAYAGPAQSLGSFVHCEPCDEKALSMCPPSPLGC-ELVKEPGCGCCMTCALAEGQ 65
Query: 70 ACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGS--PESPEST 127
+CGV T RCA+GL C E++PLHAL G+G C+ E E S E P ++
Sbjct: 66 SCGVYTERCAQGLRCLPRQDEEKPLHALLHGRGVCLNEKSYREQVKIERDSREHEEPTTS 125
Query: 128 EITEE----ELLDNFHLMAPSEEDHSILWDAISTYDGSK------------ALHVTNIKK 171
E+ EE ++ H + ++ D SK + +++
Sbjct: 126 EMAEETYSPKIFRPKHTRISELKAEAVKKDRRKKLTQSKFVGGAENTAHPRIISAPEMRQ 185
Query: 172 WKE--PCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCW 229
E PCR + ++ L + + YLPNC++ GFY +QC+ S + G+CW
Sbjct: 186 ESEQGPCRRHMEASLQELKASPRMVPRAV---YLPNCDRKGFYKRKQCKPSRGRKRGICW 242
Query: 230 CVYPWNGKRIPGSPEIRGDPNCQIY 254
CV + G ++PG + GD C +
Sbjct: 243 CVDKY-GMKLPGMEYVDGDFQCHTF 266
>gi|62243068 insulin-like growth factor binding protein 3 isoform b
precursor [Homo sapiens]
Length = 291
Score = 124 bits (310), Expect = 1e-28
Identities = 82/242 (33%), Positives = 109/242 (45%), Gaps = 35/242 (14%)
Query: 29 QCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALP 88
+C PC A LA C P A C+E+ R GCGCC CAL G CG+ T RC GL C+ P
Sbjct: 39 RCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSP 98
Query: 89 GEQQPLHALTRGQGACVQESDAS--------APHAA----------EAGSPESPESTEIT 130
E +PL AL G+G CV S S AP A AGS ESP S T
Sbjct: 99 DEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESP-SVSST 157
Query: 131 EEELLDNFHLM-----------APSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIE 179
FH + A + + + +++ ST D + + PCR E
Sbjct: 158 HRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQST-DTQNFSSESKRETEYGPCRRE 216
Query: 180 LYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRI 239
+ + L S + ++PNC+K GFY +QC S + G CWCV + G+ +
Sbjct: 217 MEDTLNHLKFLNVLSPRGV---HIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDKY-GQPL 272
Query: 240 PG 241
PG
Sbjct: 273 PG 274
>gi|62243248 insulin-like growth factor binding protein 3 isoform a
precursor [Homo sapiens]
Length = 297
Score = 121 bits (304), Expect = 5e-28
Identities = 82/248 (33%), Positives = 109/248 (43%), Gaps = 41/248 (16%)
Query: 29 QCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARGLSCRALP 88
+C PC A LA C P A C+E+ R GCGCC CAL G CG+ T RC GL C+ P
Sbjct: 39 RCEPCDARALAQCAPPPAVCAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPSP 98
Query: 89 GEQQPLHALTRGQGACVQESDAS--------APHAA----------------EAGSPESP 124
E +PL AL G+G CV S S AP A AGS ESP
Sbjct: 99 DEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGEPPAPGNASESEEDRSAGSVESP 158
Query: 125 ESTEITEEELLDNFHLM-----------APSEEDHSILWDAISTYDGSKALHVTNIKKWK 173
S T FH + A + + + +++ ST D + +
Sbjct: 159 -SVSSTHRVSDPKFHPLHSKIIIIKKGHAKDSQRYKVDYESQST-DTQNFSSESKRETEY 216
Query: 174 EPCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYP 233
PCR E+ + L S + ++PNC+K GFY +QC S + G CWCV
Sbjct: 217 GPCRREMEDTLNHLKFLNVLSPRGV---HIPNCDKKGFYKKKQCRPSKGRKRGFCWCVDK 273
Query: 234 WNGKRIPG 241
+ G+ +PG
Sbjct: 274 Y-GQPLPG 280
>gi|11321593 insulin-like growth factor binding protein 6 [Homo
sapiens]
Length = 240
Score = 95.1 bits (235), Expect = 5e-20
Identities = 72/245 (29%), Positives = 100/245 (40%), Gaps = 24/245 (9%)
Query: 11 LVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEV----TRSAGCGCCPMCALP 66
L+LLL + GA +C C A CP C E + + GC C
Sbjct: 10 LLLLLALLLAASPGGALARCPGCGQGVQAGCP---GGCVEEEDGGSPAEGCAEAEGCLRR 66
Query: 67 LGAACGVATARCARGLSCRALPGEQQPLHALTRGQGACVQESDASAPHAAEAGSPESPES 126
G CGV T CA GL C ++ PL AL G+G C+ A AP AE ES
Sbjct: 67 EGQECGVYTPNCAPGLQCHPPKDDEAPLRALLLGRGRCL---PARAPAVAEENPKESKPQ 123
Query: 127 TEITEEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVES 186
+ ++ ++ + + S + T + PCR L V++
Sbjct: 124 AGTARPQDVNR------RDQQRNPGTSTTPSQPNSAGVQDTEM----GPCRRHLDSVLQQ 173
Query: 187 LAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIR 246
L + + Y+PNC+ GFY RQC +S G CWCV GK +PGSP+
Sbjct: 174 LQTEVYRGAQTL---YVPNCDHRGFYRKRQCRSSQGQRRGPCWCV-DRMGKSLPGSPDGN 229
Query: 247 GDPNC 251
G +C
Sbjct: 230 GSSSC 234
>gi|4506141 HtrA serine peptidase 1 precursor [Homo sapiens]
Length = 480
Score = 55.5 bits (132), Expect = 5e-08
Identities = 31/85 (36%), Positives = 35/85 (41%), Gaps = 7/85 (8%)
Query: 22 VTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARCARG 81
+ AG P +C P A CPP C CGCC +C P GAACG+ C G
Sbjct: 33 LAAGCPDRCEP------ARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEG 86
Query: 82 LSCRALPGEQQPLHALTRGQ-GACV 105
L C G R Q G CV
Sbjct: 87 LQCVVPFGVPASATVRRRAQAGLCV 111
>gi|24308277 SPARC related modular calcium binding 2 [Homo sapiens]
Length = 457
Score = 47.4 bits (111), Expect = 1e-05
Identities = 24/73 (32%), Positives = 35/73 (47%), Gaps = 5/73 (6%)
Query: 179 ELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKR 238
++ R V QE + +E + ++P CN +G Y QC + G CWCV P NG+
Sbjct: 86 DVSRCVAERKYTQEQARKEFQQVFIPECNDDGTYSQVQCHS----YTGYCWCVTP-NGRP 140
Query: 239 IPGSPEIRGDPNC 251
I G+ P C
Sbjct: 141 ISGTAVAHKTPRC 153
Score = 38.5 bits (88), Expect = 0.006
Identities = 20/66 (30%), Positives = 29/66 (43%), Gaps = 7/66 (10%)
Query: 186 SLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEI 245
+L +A++ + + +P C G Y QC S G CWCV G+ IPG+
Sbjct: 234 ALEEAKQPKNDNV---VIPECAHGGLYKPVQCHPS----TGYCWCVLVDTGRPIPGTSTR 286
Query: 246 RGDPNC 251
P C
Sbjct: 287 YEQPKC 292
>gi|4504619 insulin-like growth factor binding protein 7 [Homo
sapiens]
Length = 282
Score = 46.6 bits (109), Expect = 2e-05
Identities = 29/77 (37%), Positives = 35/77 (45%), Gaps = 8/77 (10%)
Query: 11 LVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAA 70
L+LLLL + ++ C PC PP+ E TR A CGCCPMCA G
Sbjct: 16 LLLLLLPLSSSSSSDT---CGPCEPASCPPLPPLGCLLGE-TRDA-CGCCPMCARGEGEP 70
Query: 71 C---GVATARCARGLSC 84
C G CA G+ C
Sbjct: 71 CGGGGAGRGYCAPGMEC 87
>gi|55770862 thyroglobulin [Homo sapiens]
Length = 2768
Score = 45.4 bits (106), Expect = 5e-05
Identities = 25/73 (34%), Positives = 37/73 (50%), Gaps = 8/73 (10%)
Query: 179 ELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKR 238
+L V+E++ +Q T + + ++P+C G Y QC +G CWCV W GK
Sbjct: 594 DLGDVMETVLSSQ-TCEQTPERLFVPSCTTEGSYEDVQC------FSGECWCVNSW-GKE 645
Query: 239 IPGSPEIRGDPNC 251
+PGS G P C
Sbjct: 646 LPGSRVRGGQPRC 658
Score = 40.0 bits (92), Expect = 0.002
Identities = 19/50 (38%), Positives = 28/50 (56%), Gaps = 6/50 (12%)
Query: 202 YLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNC 251
Y+P+C +NG Y + QC+T G CWCV GK + G+ + P+C
Sbjct: 315 YVPSCRRNGDYQAVQCQTE-----GPCWCV-DAQGKEMHGTRQQGEPPSC 358
Score = 32.0 bits (71), Expect = 0.55
Identities = 16/41 (39%), Positives = 24/41 (58%), Gaps = 5/41 (12%)
Query: 202 YLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGS 242
Y+P C ++G + + QC+ DG + CWCV NG + GS
Sbjct: 48 YVPQCAEDGSFQTVQCQN--DGRS--CWCVGA-NGSEVLGS 83
Score = 29.6 bits (65), Expect = 2.7
Identities = 17/58 (29%), Positives = 25/58 (43%), Gaps = 5/58 (8%)
Query: 202 YLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNCQIYFNVQN 259
YLP C +G Y QC D + CWCV G + G+ ++ C ++N
Sbjct: 116 YLPQCQDSGDYAPVQC----DVQQVQCWCV-DAEGMEVYGTRQLGRPKRCPRSCEIRN 168
>gi|4759164 sparc/osteonectin, cwcv and kazal-like domains
proteoglycan 1 precursor [Homo sapiens]
Length = 439
Score = 44.7 bits (104), Expect = 8e-05
Identities = 25/78 (32%), Positives = 42/78 (53%), Gaps = 12/78 (15%)
Query: 175 PCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPW 234
PC+ E+ R+ + L+K + G ++P CN+ G+Y + QC G G CWCV +
Sbjct: 312 PCQNEMNRI-QKLSKGKSLLGA-----FIPRCNEEGYYKATQCH----GSTGQCWCVDKY 361
Query: 235 NGKRIPGSPEIRGDPNCQ 252
G + GS + +G +C+
Sbjct: 362 -GNELAGSRK-QGAVSCE 377
>gi|78190498 secreted modular calcium-binding protein 1 isoform 1
[Homo sapiens]
Length = 435
Score = 43.5 bits (101), Expect = 2e-04
Identities = 26/76 (34%), Positives = 35/76 (46%), Gaps = 12/76 (15%)
Query: 176 CRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWN 235
CR+E + +E K QE ++P C ++G + QC T G CWCV P +
Sbjct: 95 CRLERAQALEQAKKPQEA-------VFVPECGEDGSFTQVQCHT----YTGYCWCVTP-D 142
Query: 236 GKRIPGSPEIRGDPNC 251
GK I GS P C
Sbjct: 143 GKPISGSSVQNKTPVC 158
Score = 39.7 bits (91), Expect = 0.003
Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 15/121 (12%)
Query: 132 EELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQ 191
+ + D + AP+ LW SK L+ TNI+ ++ + R +L +AQ
Sbjct: 188 QPVFDGDEITAPT------LWIKHLVIKDSK-LNNTNIRNSEKVYSCDQERQ-SALEEAQ 239
Query: 192 ETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNC 251
+ E I +P C G Y QC S G CWCV G+ +PG+ P+C
Sbjct: 240 QNPREGI---VIPECAPGGLYKPVQCHQS----TGYCWCVLVDTGRPLPGTSTRYVMPSC 292
Query: 252 Q 252
+
Sbjct: 293 E 293
>gi|11545873 secreted modular calcium-binding protein 1 isoform 2
[Homo sapiens]
Length = 434
Score = 43.5 bits (101), Expect = 2e-04
Identities = 26/76 (34%), Positives = 35/76 (46%), Gaps = 12/76 (15%)
Query: 176 CRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWN 235
CR+E + +E K QE ++P C ++G + QC T G CWCV P +
Sbjct: 95 CRLERAQALEQAKKPQEA-------VFVPECGEDGSFTQVQCHT----YTGYCWCVTP-D 142
Query: 236 GKRIPGSPEIRGDPNC 251
GK I GS P C
Sbjct: 143 GKPISGSSVQNKTPVC 158
Score = 39.7 bits (91), Expect = 0.003
Identities = 34/121 (28%), Positives = 52/121 (42%), Gaps = 15/121 (12%)
Query: 132 EELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKAQ 191
+ + D + AP+ LW SK L+ TNI+ ++ + R +L +AQ
Sbjct: 188 QPVFDGDEITAPT------LWIKHLVIKDSK-LNNTNIRNSEKVYSCDQERQ-SALEEAQ 239
Query: 192 ETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNC 251
+ E I +P C G Y QC S G CWCV G+ +PG+ P+C
Sbjct: 240 QNPREGI---VIPECAPGGLYKPVQCHQS----TGYCWCVLVDTGRPLPGTSTRYVMPSC 292
Query: 252 Q 252
+
Sbjct: 293 E 293
>gi|7662036 sparc/osteonectin, cwcv and kazal-like domains
proteoglycan (testican) 2 isoform 2 [Homo sapiens]
Length = 424
Score = 43.1 bits (100), Expect = 2e-04
Identities = 27/79 (34%), Positives = 42/79 (53%), Gaps = 16/79 (20%)
Query: 172 WKE--PCRIELYRVVESLAKAQETSGEEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCW 229
W+E PC EL R+ + QE + ++ F +P+C+++G+Y QC+ S +G CW
Sbjct: 307 WREKPPCLAELERI-----QIQEAAKKKPGIF-IPSCDEDGYYRKMQCDQS----SGDCW 356
Query: 230 CV----YPWNGKRIPGSPE 244
CV G R GSP+
Sbjct: 357 CVDQLGLELTGTRTHGSPD 375
>gi|56090548 insulin-like growth factor binding protein-like 1 [Homo
sapiens]
Length = 278
Score = 43.1 bits (100), Expect = 2e-04
Identities = 35/108 (32%), Positives = 47/108 (43%), Gaps = 14/108 (12%)
Query: 4 VPVARVWLVLLL--LTVQVGV--TAGAPWQCAPCSAEKLALCP-PVSASCSEVTRSAGCG 58
+P+ + L+ LL L+ +G+ G +C PC E CP P ++ CG
Sbjct: 8 LPLLLLLLLPLLPPLSPSLGIRDVGGRRPKCGPCRPEG---CPAPAPCPAPGISALDECG 64
Query: 59 CCPMCALPLGAAC-GVATARCARGLSCRALPGEQQPLHALTRGQGACV 105
CC C GA+C G A RC GL C + Q A G G CV
Sbjct: 65 CCARCLGAEGASCGGRAGGRCGPGLVCAS-----QAAGAAPEGTGLCV 107
>gi|93141003 testican 3 isoform 1 [Homo sapiens]
Length = 433
Score = 42.7 bits (99), Expect = 3e-04
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 14/84 (16%)
Query: 175 PCRIELYRVVESLAKAQETSG-EEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYP 233
PC+ EL + Q+ G +++ Y+P C+++G+Y QC G G CWCV
Sbjct: 313 PCQTELSNI-------QKRQGVKKLLGQYIPLCDEDGYYKPTQCH----GSVGQCWCVDR 361
Query: 234 WNGKRIPGSPEIRGDPNCQIYFNV 257
+ G + GS I G +C I F +
Sbjct: 362 Y-GNEVMGS-RINGVADCAIDFEI 383
>gi|93141001 testican 3 isoform 2 [Homo sapiens]
Length = 436
Score = 42.7 bits (99), Expect = 3e-04
Identities = 27/84 (32%), Positives = 42/84 (50%), Gaps = 14/84 (16%)
Query: 175 PCRIELYRVVESLAKAQETSG-EEISKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYP 233
PC+ EL + Q+ G +++ Y+P C+++G+Y QC G G CWCV
Sbjct: 316 PCQTELSNI-------QKRQGVKKLLGQYIPLCDEDGYYKPTQCH----GSVGQCWCVDR 364
Query: 234 WNGKRIPGSPEIRGDPNCQIYFNV 257
+ G + GS I G +C I F +
Sbjct: 365 Y-GNEVMGS-RINGVADCAIDFEI 386
>gi|68448544 CD74 antigen isoform a [Homo sapiens]
Length = 296
Score = 42.4 bits (98), Expect = 4e-04
Identities = 21/50 (42%), Positives = 27/50 (54%), Gaps = 6/50 (12%)
Query: 202 YLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGDPNC 251
+ P C++NG Y QC G G CWCV+P NG +P + RG NC
Sbjct: 228 FRPKCDENGNYLPLQCY----GSIGYCWCVFP-NGTEVPNT-RSRGHHNC 271
>gi|18491000 WNT1 inducible signaling pathway protein 1 isoform 2
precursor [Homo sapiens]
Length = 280
Score = 40.8 bits (94), Expect = 0.001
Identities = 60/230 (26%), Positives = 85/230 (36%), Gaps = 53/230 (23%)
Query: 23 TAGAPWQCA-PCSAEKLALCPPVSASC----SEVTRSAGCGCCPMCALPLGAACGVATAR 77
T+ P C PC CPP C S +T GC CC MCA LG C A A
Sbjct: 42 TSSRPQFCKWPCE------CPPSPPRCPLGVSLITD--GCECCKMCAQQLGDNCTEA-AI 92
Query: 78 C--ARGLSCRALPGEQQPLHALTRGQGAC---VQESDASAPHAAEAGSPESPESTE--IT 130
C RGL C +P +A+ G C V E +A + SP SP ST +
Sbjct: 93 CDPHRGLYCDY--SGDRPRYAI----GVCAHAVGEVEAWHRNCIAYTSPWSPCSTSCGLG 146
Query: 131 EEELLDNFHLMAPSEEDHSILWDAISTYDGSKALHVTNIKKWKEPCRIELYRVVESLAKA 190
+ N + E++ + N++ PC ++++ ++++ K
Sbjct: 147 VSTRISNVNAQCWPEQES----------------RLCNLR----PCDVDIHTLIKAGKKC 186
Query: 191 QETSGEEIS-KFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRI 239
E S F L C Y + C MD C P+ K I
Sbjct: 187 LAVYQPEASMNFTLAGCISTRSYQPKYCGVCMDNR-----CCIPYKSKTI 231
>gi|144953895 nidogen 2 precursor [Homo sapiens]
Length = 1375
Score = 40.4 bits (93), Expect = 0.002
Identities = 19/55 (34%), Positives = 30/55 (54%), Gaps = 7/55 (12%)
Query: 199 SKFYLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGSPEIRGD--PNC 251
++F++P C++ G + QC G G CWCV P +G +PG+ G P+C
Sbjct: 956 ARFHIPQCDEQGNFLPLQCH----GSTGFCWCVDP-DGHEVPGTQTPPGSTPPHC 1005
>gi|208022668 endothelial cell-specific molecule 1 isoform b
precursor [Homo sapiens]
Length = 134
Score = 35.4 bits (80), Expect = 0.050
Identities = 34/116 (29%), Positives = 42/116 (36%), Gaps = 25/116 (21%)
Query: 12 VLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPV--SASCSEVTRSA-----GCGCCPMCA 64
VLLL T+ V A W S CP S+ C R CGCC +CA
Sbjct: 4 VLLLTTLLVPAHLVAAW-----SNNYAVDCPQHCDSSECKSSPRCKRTVLDDCGCCRVCA 58
Query: 65 LPLGAAC-----GVATARCARGLSCRALPGEQQ--------PLHALTRGQGACVQE 107
G C G+ +C GL C+ GE H + G G V+E
Sbjct: 59 AGRGETCYRTVSGMDGMKCGPGLRCQPSNGEDPFGEEFGICKEHDMASGDGNIVRE 114
>gi|4507923 WNT1 inducible signaling pathway protein 2 precursor
[Homo sapiens]
Length = 250
Score = 35.4 bits (80), Expect = 0.050
Identities = 22/70 (31%), Positives = 32/70 (45%), Gaps = 9/70 (12%)
Query: 56 GCGCCPMCALPLGAACG-VATARCARGLSCR--ALPGEQQPLHALTRGQGAC------VQ 106
GCGCC +CA LG C + ++GL C+ A PG + L L +C +
Sbjct: 49 GCGCCRVCARRLGEPCDQLHVCDASQGLVCQPGAGPGGRGALCLLAEDDSSCEVNGRLYR 108
Query: 107 ESDASAPHAA 116
E + PH +
Sbjct: 109 EGETFQPHCS 118
>gi|4505423 nephroblastoma overexpressed precursor [Homo sapiens]
Length = 357
Score = 35.4 bits (80), Expect = 0.050
Identities = 21/62 (33%), Positives = 27/62 (43%), Gaps = 9/62 (14%)
Query: 12 VLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSA--GCGCCPMCALPLGA 69
+LL L QV T P QC CP +C+ R+ GC CC +CA G
Sbjct: 21 LLLHLLGQVAATQRCPPQCP-------GRCPATPPTCAPGVRAVLDGCSCCLVCARQRGE 73
Query: 70 AC 71
+C
Sbjct: 74 SC 75
>gi|4503123 connective tissue growth factor [Homo sapiens]
Length = 349
Score = 35.0 bits (79), Expect = 0.065
Identities = 27/71 (38%), Positives = 31/71 (43%), Gaps = 8/71 (11%)
Query: 1 MSEVPVARVWLVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCC 60
M V VA V L+ L VG P +C A + CP A S V GCGCC
Sbjct: 6 MGPVRVAFVVLLALCSRPAVGQNCSGPCRCPDEPAPR---CP---AGVSLVLD--GCGCC 57
Query: 61 PMCALPLGAAC 71
+CA LG C
Sbjct: 58 RVCAKQLGELC 68
>gi|5901946 endothelial cell-specific molecule 1 isoform a
precursor [Homo sapiens]
Length = 184
Score = 34.7 bits (78), Expect = 0.085
Identities = 29/91 (31%), Positives = 35/91 (38%), Gaps = 17/91 (18%)
Query: 12 VLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPV--SASCSEVTRSA-----GCGCCPMCA 64
VLLL T+ V A W S CP S+ C R CGCC +CA
Sbjct: 4 VLLLTTLLVPAHLVAAW-----SNNYAVDCPQHCDSSECKSSPRCKRTVLDDCGCCRVCA 58
Query: 65 LPLGAAC-----GVATARCARGLSCRALPGE 90
G C G+ +C GL C+ GE
Sbjct: 59 AGRGETCYRTVSGMDGMKCGPGLRCQPSNGE 89
>gi|10092639 cysteine-rich motor neuron 1 [Homo sapiens]
Length = 1036
Score = 33.1 bits (74), Expect = 0.25
Identities = 26/81 (32%), Positives = 29/81 (35%), Gaps = 10/81 (12%)
Query: 11 LVLLLLTVQVGVTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAA 70
L LLLL + G A C PC K +C CGCC CA +
Sbjct: 21 LGLLLLLARSGTRALV---CLPCDESKCE----EPRNCPGSIVQGVCGCCYTCASQRNES 73
Query: 71 CGVA---TARCARGLSCRALP 88
CG C RGL C P
Sbjct: 74 CGGTFGIYGTCDRGLRCVIRP 94
>gi|115298674 nidogen 1 precursor [Homo sapiens]
Length = 1247
Score = 33.1 bits (74), Expect = 0.25
Identities = 14/41 (34%), Positives = 22/41 (53%), Gaps = 5/41 (12%)
Query: 202 YLPNCNKNGFYHSRQCETSMDGEAGLCWCVYPWNGKRIPGS 242
++P C+ +G Y QC G G CWCV +G+ + G+
Sbjct: 874 FVPECDAHGHYAPTQCH----GSTGYCWCV-DRDGREVEGT 909
>gi|4507921 WNT1 inducible signaling pathway protein 1 isoform 1
precursor [Homo sapiens]
Length = 367
Score = 32.7 bits (73), Expect = 0.32
Identities = 28/69 (40%), Positives = 30/69 (43%), Gaps = 16/69 (23%)
Query: 23 TAGAPWQCA-PCSAEKLALCPPVSASC----SEVTRSAGCGCCPMCALPLGAACGVATAR 77
T+ P C PC CPP C S +T GC CC MCA LG C A A
Sbjct: 42 TSSRPQFCKWPCE------CPPSPPRCPLGVSLITD--GCECCKMCAQQLGDNCTEA-AI 92
Query: 78 C--ARGLSC 84
C RGL C
Sbjct: 93 CDPHRGLYC 101
>gi|30387656 late cornified envelope 1B [Homo sapiens]
Length = 118
Score = 32.3 bits (72), Expect = 0.42
Identities = 27/94 (28%), Positives = 38/94 (40%), Gaps = 17/94 (18%)
Query: 22 VTAGAPWQCAPCSAEKLALCPPVSASCSEVTRSAGCGCCPMCALPLGAACGVATARC--A 79
+T P +C P CPPVS+ CS S GC C G +CG ++ C +
Sbjct: 25 LTPRCPPKCPP-------KCPPVSSCCS--VSSGGC-----CGSSSGGSCGSSSGGCCSS 70
Query: 80 RGLSCRALPGEQQPLHA-LTRGQGACVQESDASA 112
G C ++ H + G C Q S S+
Sbjct: 71 GGGGCCLSHHRRRRSHCHRPQSSGCCSQPSGGSS 104
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.429
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,630,103
Number of Sequences: 37866
Number of extensions: 580037
Number of successful extensions: 2433
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 21
Number of HSP's successfully gapped in prelim test: 76
Number of HSP's that attempted gapping in prelim test: 2344
Number of HSP's gapped (non-prelim): 157
length of query: 259
length of database: 18,247,518
effective HSP length: 100
effective length of query: 159
effective length of database: 14,460,918
effective search space: 2299285962
effective search space used: 2299285962
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 61 (28.1 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.