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Search of human proteins with 4503165
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|4503165 cullin 3 [Homo sapiens]
(768 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|4503165 cullin 3 [Homo sapiens] 1523 0.0
gi|121114302 cullin 4B isoform 2 [Homo sapiens] 503 e-142
gi|121114298 cullin 4B isoform 1 [Homo sapiens] 503 e-142
gi|57165424 cullin 4A isoform 1 [Homo sapiens] 500 e-141
gi|11140811 cullin 4A isoform 2 [Homo sapiens] 478 e-135
gi|32307161 cullin 1 [Homo sapiens] 372 e-103
gi|19482174 cullin 2 [Homo sapiens] 315 1e-85
gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1 ... 243 5e-64
gi|109452597 chromosome 10 open reading frame 46 [Homo sapiens] 51 4e-06
gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens] 42 0.002
gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo... 38 0.031
gi|218505835 membrane-associated guanylate kinase-related 3 iso... 37 0.090
gi|169218008 PREDICTED: similar to anaphase-promoting complex su... 36 0.12
gi|41406057 amyloid beta A4 protein isoform c precursor [Homo sa... 34 0.58
gi|41406055 amyloid beta A4 protein isoform b precursor [Homo sa... 34 0.58
gi|4502167 amyloid beta A4 protein isoform a precursor [Homo sap... 34 0.58
gi|209915570 amyloid beta A4 protein isoform e precursor [Homo s... 34 0.58
gi|209915573 amyloid beta A4 protein isoform f precursor [Homo s... 34 0.58
gi|58331268 excision repair protein ERCC6-like [Homo sapiens] 34 0.58
gi|224586773 hypothetical protein LOC643854 [Homo sapiens] 33 1.00
gi|66882532 farnesyltransferase, CAAX box, alpha isoform c [Homo... 33 1.00
gi|66882524 farnesyltransferase, CAAX box, alpha isoform b [Homo... 33 1.00
gi|4503771 farnesyltransferase, CAAX box, alpha isoform a [Homo ... 33 1.00
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 33 1.00
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 33 1.00
gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isofo... 32 1.7
gi|167614504 laminin, beta 1 precursor [Homo sapiens] 32 2.2
gi|34878904 synaptonemal complex protein 1 [Homo sapiens] 31 5.0
gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens] 31 5.0
gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens] 31 5.0
>gi|4503165 cullin 3 [Homo sapiens]
Length = 768
Score = 1523 bits (3943), Expect = 0.0
Identities = 768/768 (100%), Positives = 768/768 (100%)
Query: 1 MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRN 60
MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRN
Sbjct: 1 MSNLSKGTGSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRN 60
Query: 61 AYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIR 120
AYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIR
Sbjct: 61 AYTMVLHKHGEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIR 120
Query: 121 DILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR 180
DILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR
Sbjct: 121 DILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDR 180
Query: 181 GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEAR 240
GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEAR
Sbjct: 181 GAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEAR 240
Query: 241 INEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY 300
INEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY
Sbjct: 241 INEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMY 300
Query: 301 KLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF 360
KLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF
Sbjct: 301 KLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESF 360
Query: 361 NNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFR 420
NNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFR
Sbjct: 361 NNDRLFKQTIAGDFEYFLNLNSRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFR 420
Query: 421 FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSIS 480
FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSIS
Sbjct: 421 FMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSIS 480
Query: 481 NTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL 540
NTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL
Sbjct: 481 NTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYL 540
Query: 541 AKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMT 600
AKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMT
Sbjct: 541 AKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMT 600
Query: 601 ILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFT 660
ILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFT
Sbjct: 601 ILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFT 660
Query: 661 VNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHN 720
VNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHN
Sbjct: 661 VNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHN 720
Query: 721 VLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
VLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA
Sbjct: 721 VLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
>gi|121114302 cullin 4B isoform 2 [Homo sapiens]
Length = 895
Score = 503 bits (1296), Expect = e-142
Identities = 291/749 (38%), Positives = 440/749 (58%), Gaps = 48/749 (6%)
Query: 25 MDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH 84
+ E Y + W LK A++ IQ + + EELY+ + +K LY LR++ +H
Sbjct: 190 LPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDH 249
Query: 85 L---INKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNV-ENVY 140
+ I++ RED L+S+ FL+ +++ W +H M+MIR I +++DR YV QN++ +++
Sbjct: 250 IKAQIHQFREDSLDSVL--FLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIW 307
Query: 141 NLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSV 200
++GL +FR ++ +++ +L +I RER GE +DR +R+ ML L +
Sbjct: 308 DMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDL-----QI 362
Query: 201 YEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPI 260
Y++ FE FLE + + E QK + E Y+ V R+ EE +R++ LD++T++ +
Sbjct: 363 YQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSL 422
Query: 261 VKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSY 320
+ VE++L+ +H+ I++ GL ++L + +DL +Y+LFSRV G++ + + Y
Sbjct: 423 IATVEKQLLGEHLTAILQ---KGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEY 479
Query: 321 LREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNL 380
++ G +V + K V Q LLD K + D + F + F + FE F+N
Sbjct: 480 IKAFGSTIVINPEKDKTMV---QELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINK 536
Query: 381 NSRSP-EYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARR 439
P E ++ ++D KL+ G K T++E+E +LDK M++FRF+ KDVFE +YK+ LA+R
Sbjct: 537 RPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKR 596
Query: 440 LLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLG 499
LL KS S D+EK+M+SKLK ECG FTSKLEGMF+DM +S M +F+Q++Q V G
Sbjct: 597 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVP-G 655
Query: 500 GVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADL 559
++LTV +LT GYWPT + ++PP EIF+ FYL KHSGR+L Q +G L
Sbjct: 656 NIELTVNILTMGYWPTY-VPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVL 714
Query: 560 NATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQE 619
A F KE E LQVS FQ +L++FN E+++ EEI+Q
Sbjct: 715 KAEF-----KEGKKE-----------------LQVSLFQTLVLLMFNEGEEFSLEEIKQA 752
Query: 620 TDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAA 679
T I + EL R LQSLACGK RVL K PK K+IE+G F ND F KL R+KI +
Sbjct: 753 TGIEDGELRRTLQSLACGK--ARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQM 810
Query: 680 KQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPV 739
K E+ E+ T ++V DR+++I+AAIVRIMK RK + HN+LV+EV QLK F P
Sbjct: 811 K--ETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPA 866
Query: 740 VIKKRIEGLIEREYLARTPEDRKVYTYVA 768
+KKRIE LI+R+Y+ R E+ Y Y+A
Sbjct: 867 DLKKRIESLIDRDYMERDKENPNQYNYIA 895
>gi|121114298 cullin 4B isoform 1 [Homo sapiens]
Length = 913
Score = 503 bits (1296), Expect = e-142
Identities = 291/749 (38%), Positives = 440/749 (58%), Gaps = 48/749 (6%)
Query: 25 MDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHKHGEKLYTGLREVVTEH 84
+ E Y + W LK A++ IQ + + EELY+ + +K LY LR++ +H
Sbjct: 208 LPENYTDETWQKLKEAVEAIQNSTSIKYNLEELYQAVENLCSYKISANLYKQLRQICEDH 267
Query: 85 L---INKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQQNNV-ENVY 140
+ I++ RED L+S+ FL+ +++ W +H M+MIR I +++DR YV QN++ +++
Sbjct: 268 IKAQIHQFREDSLDSVL--FLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSMLPSIW 325
Query: 141 NLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQMLMILGLEGRSV 200
++GL +FR ++ +++ +L +I RER GE +DR +R+ ML L +
Sbjct: 326 DMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSMLSDL-----QI 380
Query: 201 YEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPI 260
Y++ FE FLE + + E QK + E Y+ V R+ EE +R++ LD++T++ +
Sbjct: 381 YQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQTTQKSL 440
Query: 261 VKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSY 320
+ VE++L+ +H+ I++ GL ++L + +DL +Y+LFSRV G++ + + Y
Sbjct: 441 IATVEKQLLGEHLTAILQ---KGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWIEY 497
Query: 321 LREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNL 380
++ G +V + K V Q LLD K + D + F + F + FE F+N
Sbjct: 498 IKAFGSTIVINPEKDKTMV---QELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINK 554
Query: 381 NSRSP-EYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARR 439
P E ++ ++D KL+ G K T++E+E +LDK M++FRF+ KDVFE +YK+ LA+R
Sbjct: 555 RPNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKR 614
Query: 440 LLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLG 499
LL KS S D+EK+M+SKLK ECG FTSKLEGMF+DM +S M +F+Q++Q V G
Sbjct: 615 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVP-G 673
Query: 500 GVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADL 559
++LTV +LT GYWPT + ++PP EIF+ FYL KHSGR+L Q +G L
Sbjct: 674 NIELTVNILTMGYWPTY-VPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVL 732
Query: 560 NATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQE 619
A F KE E LQVS FQ +L++FN E+++ EEI+Q
Sbjct: 733 KAEF-----KEGKKE-----------------LQVSLFQTLVLLMFNEGEEFSLEEIKQA 770
Query: 620 TDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAA 679
T I + EL R LQSLACGK RVL K PK K+IE+G F ND F KL R+KI +
Sbjct: 771 TGIEDGELRRTLQSLACGK--ARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQM 828
Query: 680 KQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPV 739
K E+ E+ T ++V DR+++I+AAIVRIMK RK + HN+LV+EV QLK F P
Sbjct: 829 K--ETVEEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLK--FPVKPA 884
Query: 740 VIKKRIEGLIEREYLARTPEDRKVYTYVA 768
+KKRIE LI+R+Y+ R E+ Y Y+A
Sbjct: 885 DLKKRIESLIDRDYMERDKENPNQYNYIA 913
>gi|57165424 cullin 4A isoform 1 [Homo sapiens]
Length = 759
Score = 500 bits (1288), Expect = e-141
Identities = 302/765 (39%), Positives = 436/765 (56%), Gaps = 49/765 (6%)
Query: 9 GSRKDTKMRIRAFPMTMDEKYVNSIWDLLKNAIQEIQRKNNSGLSFEELYRNAYTMVLHK 68
GS+K R P D Y W L A++ +Q + + EELY+ + HK
Sbjct: 39 GSKKLVIKNFRDRPRLPDN-YTQDTWRKLHEAVRAVQSSTSIRYNLEELYQAVENLCSHK 97
Query: 69 HGEKLYTGLREVVTEHLINKV---REDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMY 125
LY LR+ +H+ ++ RED L+S+ FL+ +N W DH M+MIR I ++
Sbjct: 98 VSPMLYKQLRQACEDHVQAQILPFREDSLDSVL--FLKKINTCWQDHCRQMIMIRSIFLF 155
Query: 126 MDRVYVQQNN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIR 184
+DR YV QN+ + +++++GL +FR ++ ++ +L +I RER GE VDR +R
Sbjct: 156 LDRTYVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLR 215
Query: 185 NACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEE 244
+ ML L VY++ FE FLE + + E Q+ + E Y+ V R+ EE
Sbjct: 216 SLLGMLSDL-----QVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEE 270
Query: 245 IERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFS 304
+RV+ LD ST++P++ VE++L+ +H+ I++ GL H+L + DL MY+LFS
Sbjct: 271 GDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLDHLLDENRVPDLAQMYQLFS 327
Query: 305 RVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDR 364
RV G + + + S Y++ G A+V + K D +Q LLD K + D + F +
Sbjct: 328 RVRGGQQALLQHWSEYIKTFGTAIVINPEKDK---DMVQDLLDFKDKVDHVIEVCFQKNE 384
Query: 365 LFKQTIAGDFEYFLNLNSRSP-EYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQ 423
F + FE F+N P E ++ +D KL+ G K T++E+E LDK M+LFRF+
Sbjct: 385 RFVNLMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIH 444
Query: 424 EKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTT 483
KDVFE +YK+ LA+RLL KS S D+EK+M+SKLK ECG FTSKLEGMF+DM +S
Sbjct: 445 GKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDI 504
Query: 484 MDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKH 543
M F+QH+Q S G +DLTV +LT GYWPT + + ++ P E+F+ FYL KH
Sbjct: 505 MVHFKQHMQNQSDS-GPIDLTVNILTMGYWPTYTPM-EVHLTPEMIKLQEVFKAFYLGKH 562
Query: 544 SGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILM 603
SGR+L Q +G A L A F KE E QVS FQ +L+
Sbjct: 563 SGRKLQWQTTLGHAVLKAEF-----KEGKKE-----------------FQVSLFQTLVLL 600
Query: 604 LFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVND 663
+FN + ++FEEI+ T I + EL R LQSLACGK RVL K PK KE+E+G F N
Sbjct: 601 MFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGK--ARVLIKSPKGKEVEDGDKFIFNG 658
Query: 664 QFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLV 723
+F KL R+KI + K E+ E+ T ++V DR+++I+AAIVRIMK RK + HN+LV
Sbjct: 659 EFKHKLFRIKINQIQMK--ETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLV 716
Query: 724 AEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
+E+ QLK F P +KKRIE LI+R+Y+ R ++ Y YVA
Sbjct: 717 SELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
>gi|11140811 cullin 4A isoform 2 [Homo sapiens]
Length = 659
Score = 478 bits (1230), Expect = e-135
Identities = 285/701 (40%), Positives = 411/701 (58%), Gaps = 48/701 (6%)
Query: 73 LYTGLREVVTEHLINKV---REDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRV 129
LY LR+ +H+ ++ RED L+S+ FL+ +N W DH M+MIR I +++DR
Sbjct: 2 LYKQLRQACEDHVQAQILPFREDSLDSVL--FLKKINTCWQDHCRQMIMIRSIFLFLDRT 59
Query: 130 YVQQNN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQ 188
YV QN+ + +++++GL +FR ++ ++ +L +I RER GE VDR +R+
Sbjct: 60 YVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLG 119
Query: 189 MLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERV 248
ML L VY++ FE FLE + + E Q+ + E Y+ V R+ EE +RV
Sbjct: 120 MLSDL-----QVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRV 174
Query: 249 MHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPN 308
+ LD ST++P++ VE++L+ +H+ I++ GL H+L + DL MY+LFSRV
Sbjct: 175 ITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLDHLLDENRVPDLAQMYQLFSRVRG 231
Query: 309 GLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQ 368
G + + + S Y++ G A+V + K D +Q LLD K + D + F + F
Sbjct: 232 GQQALLQHWSEYIKTFGTAIVINPEKDK---DMVQDLLDFKDKVDHVIEVCFQKNERFVN 288
Query: 369 TIAGDFEYFLNLNSRSP-EYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDV 427
+ FE F+N P E ++ +D KL+ G K T++E+E LDK M+LFRF+ KDV
Sbjct: 289 LMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDV 348
Query: 428 FERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEF 487
FE +YK+ LA+RLL KS S D+EK+M+SKLK ECG FTSKLEGMF+DM +S M F
Sbjct: 349 FEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHF 408
Query: 488 RQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQ 547
+QH+Q S G +DLTV +LT GYWPT + + ++ P E+F+ FYL KHSGR+
Sbjct: 409 KQHMQNQSDS-GPIDLTVNILTMGYWPTYTPM-EVHLTPEMIKLQEVFKAFYLGKHSGRK 466
Query: 548 LTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNN 607
L Q +G A L A F KE E QVS FQ +L++FN
Sbjct: 467 LQWQTTLGHAVLKAEF-----KEGKKE-----------------FQVSLFQTLVLLMFNE 504
Query: 608 REKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFTS 667
+ ++FEEI+ T I + EL R LQSLACGK RVL K PK KE+E+G F N +F
Sbjct: 505 GDGFSFEEIKMATGIEDSELRRTLQSLACGK--ARVLIKSPKGKEVEDGDKFIFNGEFKH 562
Query: 668 KLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVT 727
KL R+KI + K E+ E+ T ++V DR+++I+AAIVRIMK RK + HN+LV+E+
Sbjct: 563 KLFRIKINQIQMK--ETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELY 620
Query: 728 QQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
QLK F P +KKRIE LI+R+Y+ R ++ Y YVA
Sbjct: 621 NQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
>gi|32307161 cullin 1 [Homo sapiens]
Length = 776
Score = 372 bits (954), Expect = e-103
Identities = 245/794 (30%), Positives = 414/794 (52%), Gaps = 89/794 (11%)
Query: 30 VNSIWDLLKNAIQEIQRKNNSGLS-FEELYRNAYTMVLHKH------------------- 69
++ IWD L+ IQ++ + + S + ELY + Y H
Sbjct: 17 LDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKKGQ 76
Query: 70 --------GEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRD 121
G +LY L+E + +L N ++ D + ++ + L+ Q W D++ + ++
Sbjct: 77 TPGGAQFVGLELYKRLKEFLKNYLTNLLK-DGEDLMDESVLKFYTQQWEDYRFSSKVLNG 135
Query: 122 ILMYMDRVYVQQN------NVENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKG 175
I Y++R +V++ + +Y+L L+ +RD + R + + +L +I +ER G
Sbjct: 136 ICAYLNRHWVRRECDEGRKGIYEIYSLALVTWRDCLFRP--LNKQVTNAVLKLIEKERNG 193
Query: 176 EVVDRGAIRNACQMLMILGLEGR---------SVYEEDFEAPFLEMSAEFFQMESQKFLA 226
E ++ I Q + LGL +VY+E FE+ FL + F+ ES +FL
Sbjct: 194 ETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQ 253
Query: 227 ENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVH 286
+N + Y+KK EAR+ EE RV L +ST++ + + E+ LI KH+ E+ ++ +
Sbjct: 254 QNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHL----EIFHTEFQN 309
Query: 287 MLKNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEG--KNPVDYIQG 344
+L K EDLG MY L SR+ +GL + + + +++ QG A + + GE +P Y+Q
Sbjct: 310 LLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQT 369
Query: 345 LLDLKSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLN---------SRSPEYLSLFIDDK 395
+LD+ +++ ++ +FNND F + F+N N S+SPE L+ + D
Sbjct: 370 VLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSL 429
Query: 396 LKKGVKGLTEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMI 455
LKK K E E+E L++ MV+F+++++KDVF+++Y + LA+RL+ S SDD+E +MI
Sbjct: 430 LKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMI 489
Query: 456 SKLKTECGCQFTSKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPT 515
SKLK CG ++TSKL+ MF+D+ +S ++F++HL T +D +++VL++G WP
Sbjct: 490 SKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHL--TNSEPLDLDFSIQVLSSGSWPF 547
Query: 516 QSATPKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEV 575
Q + +P +++ F FY ++HSGR+LT + + +L
Sbjct: 548 QQSCTFA-LPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGEL---------------- 590
Query: 576 GVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLA 635
VT ++ LQ STFQM IL+ +N + YT +++ T I L + LQ L
Sbjct: 591 ------VTNCFKNRYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILL 644
Query: 636 CGKPTQRVLTKEPKS-KEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQK 694
K VL E + E+E + K ++++ + E E++ T +
Sbjct: 645 --KSKLLVLEDENANVDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKN 702
Query: 695 VDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYL 754
+++DRK I+AAIVRIMK RK ++H L+ EV QL +RF P VIKK I+ LIE+EYL
Sbjct: 703 IEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYL 762
Query: 755 ARTPEDRKVYTYVA 768
R ++ Y+Y+A
Sbjct: 763 ERVDGEKDTYSYLA 776
>gi|19482174 cullin 2 [Homo sapiens]
Length = 745
Score = 315 bits (807), Expect = 1e-85
Identities = 203/727 (27%), Positives = 375/727 (51%), Gaps = 63/727 (8%)
Query: 70 GEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRV 129
GE+LYT + + H + + + VL S L ++ W ++ + + Y++
Sbjct: 54 GERLYTETKIFLENH-VRHLHKRVLES-EEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQ 111
Query: 130 YVQQNNVENV---YNLGLIIFRDQVVRYGCIR---------DHLRQTLLDMIARERKGE- 176
++++N + Y G + + ++ G + + L+ L+ M+ RE K +
Sbjct: 112 FIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDR 171
Query: 177 -------VVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENS 229
V G I + + Y+E FE+PFL + E+++ E+ L E++
Sbjct: 172 GGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESN 231
Query: 230 ASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLK 289
S Y++KV R+ +E R L S+ ++ ++ +++ H++ + ++ ++++
Sbjct: 232 CSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFL----HAECHNIIR 287
Query: 290 NGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLK 349
K D+ MY L V GL M + + +++ ++G S + P +++ +L++
Sbjct: 288 QEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVH 347
Query: 350 SRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFIDDKLKKGVKGLT 404
+F + + N D+ F + +N ++PE L+ + D+ LKK KG+T
Sbjct: 348 GKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMT 407
Query: 405 EQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGC 464
E EVE L + +F+++ +KDVF+++Y + LA+RL+ S+S DSE+ MI+KLK CG
Sbjct: 408 ENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGY 467
Query: 465 QFTSKLEGMFRDMSISNTTMDEFRQHL--QATGVSLGGVDLTVRVLTTGYWP-TQSATPK 521
+FTSKL M+ DMS+S ++F + Q T + L G+ + VL G WP TQ+ +
Sbjct: 468 EFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDL-GISFQIYVLQAGAWPLTQAPSST 526
Query: 522 CNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQ 581
IP + ++F FY SGR+LT H++ + ++ + G
Sbjct: 527 FAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLG---------------- 570
Query: 582 VTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQ 641
+ ++ V+T+QM +L+ FNN E +++E+Q T + E+EL + ++SL
Sbjct: 571 ------KPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLL----DV 620
Query: 642 RVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKH 701
+++ + + ++I+ F++N F+SK R K + + Q ++ E ++TR VD+DRK
Sbjct: 621 KMINHDSEKEDIDAESSFSLNMNFSSK--RTKFKITTSMQKDTPQEMEQTRSAVDEDRKM 678
Query: 702 EIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDR 761
++AAIVRIMK+RK ++HN L+ EV Q +ARF PS +IKK IE LI+++Y+ R+
Sbjct: 679 YLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASA 738
Query: 762 KVYTYVA 768
Y+YVA
Sbjct: 739 DEYSYVA 745
>gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1
[Homo sapiens]
Length = 780
Score = 243 bits (620), Expect = 5e-64
Identities = 207/792 (26%), Positives = 383/792 (48%), Gaps = 87/792 (10%)
Query: 34 WDLLKNAIQEIQRKNN-SGLSFEELYRNAYTMVL--HKHGEKLYTGLREVVTEHLINKVR 90
WD ++ + ++ R+ + + + +L+ + + + L K K++ L+E + E I + +
Sbjct: 19 WDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCLWDDKGPAKIHQALKEDILE-FIKQAQ 77
Query: 91 EDVLNSLNNN-FLQTLNQAWNDHQTAMVMIRDILMYMDRVYV------QQNNVEN--VYN 141
VL+ ++ L+ W T ++ ++ + +++NVE+ V
Sbjct: 78 ARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVEDSIVRK 137
Query: 142 LGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRG---AIRNACQMLMILGLEGR 198
L L + + + + I++ L+ + + ++ ER GE D +R + L +
Sbjct: 138 LMLDTWNESI--FSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSNPEDKL 195
Query: 199 SVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTE- 257
+Y ++FE +L+ + F++ ++ +L +N Y+K +A++ EE +R + L+ E
Sbjct: 196 QIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLETRREC 255
Query: 258 ---EPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPNGLKTMC 314
E +++ L++ +TI+ E G M+K +TE L M+ L +VPNG++ M
Sbjct: 256 NSVEALMECCVNALVTSFKETILA-ECQG---MIKRNETEKLHLMFSLMDKVPNGIEPML 311
Query: 315 ECMSSYLREQGKA--LVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFK----- 367
+ + ++ G A + + E + Y++ LL L +RF + + E+F +D F
Sbjct: 312 KDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTARDK 371
Query: 368 --QTIAGDFEYF-LNL-------------NSRSPEYLSLFIDDKLKKGV--KGLTEQEVE 409
+ + D F L L S+ PE L+ + D L+K K LT +E+E
Sbjct: 372 AYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEEIE 431
Query: 410 TILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECG--CQFT 467
L + +++ +++Q KDVF RY+K HL RRL+ + S + E+NM+ L+ E G +
Sbjct: 432 AKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPADYV 490
Query: 468 SKLEGMFRDMSISNTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPA 527
+KL MF+D+ +S F++ + ++L + +++L G W S ++P
Sbjct: 491 NKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLPTE 550
Query: 528 PRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNT 587
FY HSGR+L H M + + TF V + D
Sbjct: 551 LEDLIPEVEEFYKKNHSGRKLHWHHLMSNGII--TFKNEVGQYD---------------- 592
Query: 588 RKHILQVSTFQMTILMLFNNR--EKYTFEEIQQETDIPERELVRALQSL-ACGKPTQRVL 644
L+V+TFQ+ +L +N R EK +FE ++ T++P+ EL R L SL A K ++VL
Sbjct: 593 ----LEVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVL 648
Query: 645 TKEPK---SKEIENGHIFTVNDQFT----SKLH-RVKIQTVAAKQGESDPERKETRQKVD 696
EP+ K+ G +F+VN +F+ +K+ R KI + Q ++ R+E + +
Sbjct: 649 LYEPQVNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIV 708
Query: 697 DDRKHEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLAR 756
R + AI++IMK RKK+ + L E+ + LK FLP +IK++IE LIE +Y+ R
Sbjct: 709 QLRILRTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRR 768
Query: 757 TPEDRKVYTYVA 768
D + Y+A
Sbjct: 769 DESDINTFIYMA 780
>gi|109452597 chromosome 10 open reading frame 46 [Homo sapiens]
Length = 369
Score = 51.2 bits (121), Expect = 4e-06
Identities = 27/109 (24%), Positives = 59/109 (54%), Gaps = 4/109 (3%)
Query: 27 EKYVNSIWDLLKNAIQEIQRKNNSG---LSFEELYRNAYTMVLHKHGEKLYTGLREVVTE 83
E Y ++ W L AI ++ ++ +S+E++Y Y V +H E++Y+ L + +T
Sbjct: 130 EDYKSTYWPKLDGAIDQLLTQSPGDYIPISYEQIYSCVYKCVCQQHSEQMYSDLIKKITN 189
Query: 84 HLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRVYVQ 132
HL +V +++ S + +++ N A + A+ I + +YM++ Y++
Sbjct: 190 HL-ERVSKELQASPPDLYIERFNIALGQYMGALQSIVPLFIYMNKFYIE 237
>gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens]
Length = 822
Score = 42.4 bits (98), Expect = 0.002
Identities = 59/239 (24%), Positives = 93/239 (38%), Gaps = 32/239 (13%)
Query: 413 DKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEG 472
D +L KD+F Y+ LA RLL S S + E + LK G E
Sbjct: 500 DIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEV 559
Query: 473 MFRDMSIS---NTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPR 529
M +DM+ S N + E + A GV +L++ +WP K +P R
Sbjct: 560 MLKDMADSRRINANIREEDEKRPAEEQPPFGVYAV--ILSSEFWP-PFKDEKLEVPEDIR 616
Query: 530 HAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRK 589
A E + + Y + R L+ +H +G ++ V+ D R
Sbjct: 617 AALEAYCKKYEQLKAMRTLSWKHTLGLVTMD------VELAD----------------RT 654
Query: 590 HILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEP 648
+ V+ Q IL+ F ++ +T EE+ + +P L R + Q VL +EP
Sbjct: 655 LSVAVTPVQAVILLYFQDQASWTLEELSKAVKMPVALLRRRMSVWL----QQGVLREEP 709
>gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo
sapiens]
Length = 2517
Score = 38.1 bits (87), Expect = 0.031
Identities = 35/139 (25%), Positives = 58/139 (41%), Gaps = 23/139 (16%)
Query: 503 LTVRVLTTGYWPTQSAT----PKCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSAD 558
+++ VL+ WP P+ +P A + F FY + L + H
Sbjct: 1695 ISILVLSPRCWPVSPLCYLYHPRKCLPTEFCDALDRFSSFYSQSQNHPVLDMGPHRR--- 1751
Query: 559 LNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQ 618
L T+ G + + G K IL VST QM +L+ FN E+ + E + +
Sbjct: 1752 LQWTWLGRAELQFG----------------KQILHVSTVQMWLLLKFNQTEEVSVETLLK 1795
Query: 619 ETDIPERELVRALQSLACG 637
++D+ L++AL L G
Sbjct: 1796 DSDLSPELLLQALVPLTSG 1814
>gi|218505835 membrane-associated guanylate kinase-related 3 isoform
1 [Homo sapiens]
Length = 1481
Score = 36.6 bits (83), Expect = 0.090
Identities = 23/94 (24%), Positives = 44/94 (46%), Gaps = 10/94 (10%)
Query: 617 QQETDIPERELVRALQSLACGKPTQRVLTKE----PKSKEIENGHIFTVNDQFTSKLHRV 672
+ T PE+++ R ++ K T + +KE K K++ G + ND+ +
Sbjct: 1348 KSRTRSPEKKIKRMVEKSLPSKMTNKTTSKEVSENEKGKKVTTGETSSSNDKIGENVQ-- 1405
Query: 673 KIQTVAAKQGESDPERKETRQKVDDDRKHEIEAA 706
++ K+ + +PE K K +D + E+EAA
Sbjct: 1406 ----LSEKRLKQEPEEKVVSNKTEDHKGKELEAA 1435
>gi|169218008 PREDICTED: similar to anaphase-promoting complex
subunit 2 [Homo sapiens]
Length = 430
Score = 36.2 bits (82), Expect = 0.12
Identities = 51/178 (28%), Positives = 68/178 (38%), Gaps = 30/178 (16%)
Query: 413 DKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEG 472
D +L KD+F Y+ LA RLL S S + E + LK G E
Sbjct: 274 DIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHFCEV 333
Query: 473 MFRDMSIS---NTTMDEFRQHLQATGVSLGGVDLTVRVLTTGYWPTQSATPKCNIPPAPR 529
M +DM+ S N + E + A GV +L++ +WP K +P R
Sbjct: 334 MLKDMADSRRINANIREEDEKRPAEEQPPFGVYAV--ILSSEFWP-PFKDEKLEVPEDIR 390
Query: 530 HAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKED---GSEVGVGGAQVTG 584
A E + + Y QL PV ED GS VGVGG Q+ G
Sbjct: 391 AALEAYCKKY------EQLK---------------APVVLEDRGYGSVVGVGGEQMWG 427
>gi|41406057 amyloid beta A4 protein isoform c precursor [Homo
sapiens]
Length = 695
Score = 33.9 bits (76), Expect = 0.58
Identities = 12/29 (41%), Positives = 19/29 (65%)
Query: 524 IPPAPRHAFEIFRRFYLAKHSGRQLTLQH 552
+PP PRH F + +++ A+ RQ TL+H
Sbjct: 408 VPPRPRHVFNMLKKYVRAEQKDRQHTLKH 436
>gi|41406055 amyloid beta A4 protein isoform b precursor [Homo
sapiens]
Length = 751
Score = 33.9 bits (76), Expect = 0.58
Identities = 12/29 (41%), Positives = 19/29 (65%)
Query: 524 IPPAPRHAFEIFRRFYLAKHSGRQLTLQH 552
+PP PRH F + +++ A+ RQ TL+H
Sbjct: 464 VPPRPRHVFNMLKKYVRAEQKDRQHTLKH 492
>gi|4502167 amyloid beta A4 protein isoform a precursor [Homo
sapiens]
Length = 770
Score = 33.9 bits (76), Expect = 0.58
Identities = 12/29 (41%), Positives = 19/29 (65%)
Query: 524 IPPAPRHAFEIFRRFYLAKHSGRQLTLQH 552
+PP PRH F + +++ A+ RQ TL+H
Sbjct: 483 VPPRPRHVFNMLKKYVRAEQKDRQHTLKH 511
>gi|209915570 amyloid beta A4 protein isoform e precursor [Homo
sapiens]
Length = 639
Score = 33.9 bits (76), Expect = 0.58
Identities = 12/29 (41%), Positives = 19/29 (65%)
Query: 524 IPPAPRHAFEIFRRFYLAKHSGRQLTLQH 552
+PP PRH F + +++ A+ RQ TL+H
Sbjct: 352 VPPRPRHVFNMLKKYVRAEQKDRQHTLKH 380
>gi|209915573 amyloid beta A4 protein isoform f precursor [Homo
sapiens]
Length = 714
Score = 33.9 bits (76), Expect = 0.58
Identities = 12/29 (41%), Positives = 19/29 (65%)
Query: 524 IPPAPRHAFEIFRRFYLAKHSGRQLTLQH 552
+PP PRH F + +++ A+ RQ TL+H
Sbjct: 427 VPPRPRHVFNMLKKYVRAEQKDRQHTLKH 455
>gi|58331268 excision repair protein ERCC6-like [Homo sapiens]
Length = 1250
Score = 33.9 bits (76), Expect = 0.58
Identities = 48/262 (18%), Positives = 108/262 (41%), Gaps = 42/262 (16%)
Query: 53 SFEELYRNAYTMVLHKH--------GEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQT 104
+F+ Y N T K G K+ L ++ + + + +EDV ++N
Sbjct: 285 TFKMEYENPITRAREKDATPGEKALGFKISENLMAIIKPYFLRRTKEDVQKKKSSNPEAR 344
Query: 105 LNQAWNDHQTAMVMIRDILMYMDRVYVQQNNVENVYNLGLIIFRDQVVRYGCIRDHLRQT 164
LN+ D D + M + ++N++ + + L+ ++++ R DH+++
Sbjct: 345 LNEKNPDV--------DAICEMPSLS-RKNDL--IIWIRLVPLQEEIYRKFVSLDHIKEL 393
Query: 165 LLDMIARERKGEVVDRGAIRNACQ----------MLMILGLEGRSVYEEDFEAPFLEMSA 214
L+ E + + + G ++ C L+ LG E ++P ++
Sbjct: 394 LM-----ETRSPLAELGVLKKLCDHPRLLSARACCLLNLGTFSAQDGNEGEDSPDVD--- 445
Query: 215 EFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMK 274
Q+ + E+ +++ + R+ +E + L S I+ ++ER L ++H K
Sbjct: 446 HIDQVTDDTLMEESGKMIFLMDLLKRLRDEGHQT---LVFSQSRQILNIIERLLKNRHFK 502
Query: 275 TIVEMENSGLVHMLKNGKTEDL 296
T+ + + H+L+ K +L
Sbjct: 503 TL--RIDGTVTHLLEREKRINL 522
>gi|224586773 hypothetical protein LOC643854 [Homo sapiens]
Length = 777
Score = 33.1 bits (74), Expect = 1.00
Identities = 30/114 (26%), Positives = 54/114 (47%), Gaps = 7/114 (6%)
Query: 169 IARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAEN 228
+ RE+K G I C++L E S+ ++++E +E S E E
Sbjct: 72 VGREQKLGATLSGLIEEKCKLL-----EKFSLIQKEYEGYEVESSLEDASFEKAAAEEAR 126
Query: 229 SASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVER-ELISKHMKTIVEMEN 281
S +K+ +R N E+E + CL+K +E K ++ EL++ K+I +E+
Sbjct: 127 SLEATCEKL-SRSNSELEDEILCLEKDLKEEKSKHSQQDELMADISKSIQSLED 179
>gi|66882532 farnesyltransferase, CAAX box, alpha isoform c [Homo
sapiens]
Length = 312
Score = 33.1 bits (74), Expect = 1.00
Identities = 22/74 (29%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
Query: 382 SRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFM-QEKDVFERYYKQHLARRL 440
S S YL F+ D + ++ + + E IL+KA+ L + +EKD + Y +++ R L
Sbjct: 238 SHSSPYLIAFLVDIYEDMLENQCDNK-EDILNKALELCEILAKEKDTIRKEYWRYIGRSL 296
Query: 441 LTNKSVSDDSEKNM 454
+ S +DS N+
Sbjct: 297 QSKHSTENDSPTNV 310
>gi|66882524 farnesyltransferase, CAAX box, alpha isoform b [Homo
sapiens]
Length = 288
Score = 33.1 bits (74), Expect = 1.00
Identities = 22/74 (29%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
Query: 382 SRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFM-QEKDVFERYYKQHLARRL 440
S S YL F+ D + ++ + + E IL+KA+ L + +EKD + Y +++ R L
Sbjct: 214 SHSSPYLIAFLVDIYEDMLENQCDNK-EDILNKALELCEILAKEKDTIRKEYWRYIGRSL 272
Query: 441 LTNKSVSDDSEKNM 454
+ S +DS N+
Sbjct: 273 QSKHSTENDSPTNV 286
>gi|4503771 farnesyltransferase, CAAX box, alpha isoform a [Homo
sapiens]
Length = 379
Score = 33.1 bits (74), Expect = 1.00
Identities = 22/74 (29%), Positives = 39/74 (52%), Gaps = 2/74 (2%)
Query: 382 SRSPEYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFM-QEKDVFERYYKQHLARRL 440
S S YL F+ D + ++ + + E IL+KA+ L + +EKD + Y +++ R L
Sbjct: 305 SHSSPYLIAFLVDIYEDMLENQCDNK-EDILNKALELCEILAKEKDTIRKEYWRYIGRSL 363
Query: 441 LTNKSVSDDSEKNM 454
+ S +DS N+
Sbjct: 364 QSKHSTENDSPTNV 377
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 33.1 bits (74), Expect = 1.00
Identities = 38/153 (24%), Positives = 71/153 (46%), Gaps = 11/153 (7%)
Query: 589 KHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEP 648
K++L+ + F+M L K E +++ IPE + A+ L+ KP V+ E
Sbjct: 2413 KNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2472
Query: 649 KSKEIENGHIFTVNDQ--------FTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRK 700
K +EN F ++ ++L +++ TV+AK E K+ + + + +
Sbjct: 2473 ALKSLENQTYFKSFEENGKGSIINLETRLLQLE-STVSAKDLELTQCYKQIKD-MQEQGQ 2530
Query: 701 HEIEAAIVRIMKSRKKMQHNVLVAEVTQ-QLKA 732
E E +I+ +K ++ V A V+Q QL+A
Sbjct: 2531 FETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA 2563
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 33.1 bits (74), Expect = 1.00
Identities = 38/153 (24%), Positives = 71/153 (46%), Gaps = 11/153 (7%)
Query: 589 KHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEP 648
K++L+ + F+M L K E +++ IPE + A+ L+ KP V+ E
Sbjct: 2405 KNVLKETNFKMNQLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTED 2464
Query: 649 KSKEIENGHIFTVNDQ--------FTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRK 700
K +EN F ++ ++L +++ TV+AK E K+ + + + +
Sbjct: 2465 ALKSLENQTYFKSFEENGKGSIINLETRLLQLE-STVSAKDLELTQCYKQIKD-MQEQGQ 2522
Query: 701 HEIEAAIVRIMKSRKKMQHNVLVAEVTQ-QLKA 732
E E +I+ +K ++ V A V+Q QL+A
Sbjct: 2523 FETEMLQKKIVNLQKIVEEKVAAALVSQIQLEA 2555
>gi|90819229 cutaneous T-cell lymphoma-associated antigen 1 isoform
1 [Homo sapiens]
Length = 745
Score = 32.3 bits (72), Expect = 1.7
Identities = 31/114 (27%), Positives = 55/114 (48%), Gaps = 8/114 (7%)
Query: 169 IARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAEN 228
+ RE+K V G I C++ LE S+ ++++E +E S + E + A+
Sbjct: 42 VRREKKFAVALSGLIEEKCKL-----LEKFSLVQKEYEGYEVESSLKNASFEKEATEAQ- 95
Query: 229 SASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVER-ELISKHMKTIVEMEN 281
S +K+ R N E+ + CL+K +E K E+ EL++ K I +E+
Sbjct: 96 SLEATCEKLN-RFNSELVHEILCLEKELKEEKSKHSEQNELMADISKRIQSLED 148
>gi|167614504 laminin, beta 1 precursor [Homo sapiens]
Length = 1786
Score = 32.0 bits (71), Expect = 2.2
Identities = 19/82 (23%), Positives = 39/82 (47%)
Query: 203 EDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERVMHCLDKSTEEPIVK 262
E+ + + S E +E + + SA K ++ ++E+ ++V + + K TEE
Sbjct: 1656 EELKRKAAQNSGEAEYIEKVVYTVKQSAEDVKKTLDGELDEKYKKVENLIAKKTEESADA 1715
Query: 263 VVERELISKHMKTIVEMENSGL 284
+ E++ KT++ NS L
Sbjct: 1716 RRKAEMLQNEAKTLLAQANSKL 1737
>gi|34878904 synaptonemal complex protein 1 [Homo sapiens]
Length = 976
Score = 30.8 bits (68), Expect = 5.0
Identities = 26/113 (23%), Positives = 54/113 (47%), Gaps = 16/113 (14%)
Query: 603 MLFNNREKYTFEEIQQETDIPERELVRALQS-----------LACGKPTQRVLTKEPKSK 651
+L+ N++ FE+I +E E+EL+ LQ+ L +++ +KE K
Sbjct: 446 LLYENKQ---FEKIAEELKGTEQELIGLLQAREKEVHDLEIQLTAITTSEQYYSKEVKDL 502
Query: 652 EIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDP--ERKETRQKVDDDRKHE 702
+ E + N + TS +++ ++ Q SD E K ++ +++++K E
Sbjct: 503 KTELENEKLKNTELTSHCNKLSLENKELTQETSDMTLELKNQQEDINNNKKQE 555
>gi|42740899 CTAGE family, member 5 isoform 3 [Homo sapiens]
Length = 761
Score = 30.8 bits (68), Expect = 5.0
Identities = 44/175 (25%), Positives = 79/175 (45%), Gaps = 14/175 (8%)
Query: 169 IARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAEN 228
+ RE+K ++ G I ++L E S+ ++++E +E S + E + A+
Sbjct: 72 VGREKKLALMLSGLIEEKSKLL-----EKFSLVQKEYEGYEVESSLKDASFEKEATEAQ- 125
Query: 229 SASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVER-ELISKHMKTIVEMENSGLVHM 287
S +K+ R N E+E + CL+K +E K E+ EL++ K I +E+
Sbjct: 126 SLEATCEKLN-RSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDES--KS 182
Query: 288 LKNGKTEDLGCMYKLFSRVPNGLKTMCECM---SSYLREQGKALVSEEGEGKNPV 339
LK+ + + +K+F LK + +S L+E K L+ E K V
Sbjct: 183 LKS-QVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQV 236
>gi|42740897 CTAGE family, member 5 isoform 1 [Homo sapiens]
Length = 804
Score = 30.8 bits (68), Expect = 5.0
Identities = 44/175 (25%), Positives = 79/175 (45%), Gaps = 14/175 (8%)
Query: 169 IARERKGEVVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAEN 228
+ RE+K ++ G I ++L E S+ ++++E +E S + E + A+
Sbjct: 72 VGREKKLALMLSGLIEEKSKLL-----EKFSLVQKEYEGYEVESSLKDASFEKEATEAQ- 125
Query: 229 SASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVER-ELISKHMKTIVEMENSGLVHM 287
S +K+ R N E+E + CL+K +E K E+ EL++ K I +E+
Sbjct: 126 SLEATCEKLN-RSNSELEDEILCLEKELKEEKSKHSEQDELMADISKRIQSLEDES--KS 182
Query: 288 LKNGKTEDLGCMYKLFSRVPNGLKTMCECM---SSYLREQGKALVSEEGEGKNPV 339
LK+ + + +K+F LK + +S L+E K L+ E K V
Sbjct: 183 LKS-QVAEAKMTFKIFQMNEERLKIAIKDALNENSQLQESQKQLLQEAEVWKEQV 236
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,833,068
Number of Sequences: 37866
Number of extensions: 1082658
Number of successful extensions: 3237
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 16
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 3123
Number of HSP's gapped (non-prelim): 69
length of query: 768
length of database: 18,247,518
effective HSP length: 110
effective length of query: 658
effective length of database: 14,082,258
effective search space: 9266125764
effective search space used: 9266125764
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.