Search of human proteins with 42741675

Search of human proteins with 42741675

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
         (423 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]             900   0.0  
gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]             872   0.0  
gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]            413   e-115
gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]            322   3e-88
gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]             293   2e-79
gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]            291   1e-78
gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]             291   1e-78
gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]             176   4e-44
gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]             167   2e-41
gi|109638745 transforming growth factor beta 1 induced transcrip...   165   8e-41
gi|21361591 transforming growth factor beta 1 induced transcript...   165   8e-41
gi|221316659 leupaxin isoform 1 [Homo sapiens]                        135   9e-32
gi|4758670 leupaxin isoform 2 [Homo sapiens]                          135   9e-32
gi|170932518 paxillin isoform 3 [Homo sapiens]                        131   1e-30
gi|170932516 paxillin isoform 2 [Homo sapiens]                        131   1e-30
gi|170932514 paxillin isoform 1 [Homo sapiens]                        131   1e-30
gi|238859658 LIM and senescent cell antigen-like domains 2 isofo...   131   1e-30
gi|238776788 LIM and senescent cell antigen-like domains 2 isofo...   131   1e-30
gi|238776786 LIM and senescent cell antigen-like domains 2 isofo...   131   1e-30
gi|40804748 LIM and senescent cell antigen-like domains 2 isofor...   131   1e-30
gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo ...   127   1e-29
gi|13994151 PDZ and LIM domain 1 [Homo sapiens]                       123   4e-28
gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]             122   8e-28
gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens]    119   7e-27
gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]            115   6e-26
gi|54112385 four and a half LIM domains 3 [Homo sapiens]              115   6e-26
gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]            114   2e-25
gi|7662330 actin binding LIM protein family, member 3 [Homo sapi...   111   1e-24
gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]   109   5e-24
gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]   109   5e-24

>gi|42741675 PDZ and LIM domain 7 isoform 2 [Homo sapiens]
          Length = 423

 Score =  900 bits (2325), Expect = 0.0
 Identities = 423/423 (100%), Positives = 423/423 (100%)

Query: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
           MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
Sbjct: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60

Query: 61  LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTED 120
           LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTED
Sbjct: 61  LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTED 120

Query: 121 WRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPT 180
           WRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPT
Sbjct: 121 WRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPT 180

Query: 181 APSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGS 240
           APSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGS
Sbjct: 181 APSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGS 240

Query: 241 NNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYD 300
           NNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYD
Sbjct: 241 NNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYD 300

Query: 301 VRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEK 360
           VRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEK
Sbjct: 301 VRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEK 360

Query: 361 MFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAF 420
           MFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAF
Sbjct: 361 MFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAF 420

Query: 421 SHV 423
           SHV
Sbjct: 421 SHV 423


>gi|11496885 PDZ and LIM domain 7 isoform 1 [Homo sapiens]
          Length = 457

 Score =  872 bits (2254), Expect = 0.0
 Identities = 418/457 (91%), Positives = 419/457 (91%), Gaps = 34/457 (7%)

Query: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
           MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
Sbjct: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60

Query: 61  LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTP----------------------- 97
           LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQK   P                       
Sbjct: 61  LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFG 120

Query: 98  -----------DKQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ 146
                      + QPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
Sbjct: 121 APPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ 180

Query: 147 DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS 206
           DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS
Sbjct: 181 DPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTS 240

Query: 207 TVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHA 266
           TVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHA
Sbjct: 241 TVLTRHSQPATPTPLQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHA 300

Query: 267 YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTW 326
           YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTW
Sbjct: 301 YHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTW 360

Query: 327 HVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS 386
           HVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS
Sbjct: 361 HVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFS 420

Query: 387 WHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV 423
           WHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV
Sbjct: 421 WHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV 457


>gi|197383100 PDZ and LIM domain 5 isoform b [Homo sapiens]
          Length = 487

 Score =  413 bits (1062), Expect = e-115
 Identities = 224/487 (45%), Positives = 289/487 (59%), Gaps = 69/487 (14%)

Query: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
           M ++ V L GPAPWGFRLQGGKDFN+PL+IS L  GGKAAQA V +GD VLSIDG NA  
Sbjct: 1   MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60

Query: 61  LTHIEAQNKIRACGERLSLGLSRAQPV-QSKPQKVQTP---------------------- 97
           +TH+EAQNKI+ C   L++ L RA    + +P  VQ P                      
Sbjct: 61  MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTVTSVCSETSQELAEGQRRGSQ 120

Query: 98  --DKQ---PLR-------------PLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHL 139
              KQ   P R             P   DASK+RL+E+TEDWRPR GT QSRSFRILA +
Sbjct: 121 GDSKQQNGPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQI 180

Query: 140 TGTEFMQDPDEEHLKKS--SQVPRTEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFA 197
           TGTE +++ + ++ KK+  SQ P  +  +  +ST   P    +  SPTS  P       A
Sbjct: 181 TGTEHLKESEADNTKKANNSQEPSPQLASSVASTRSMP---ESLDSPTSGRPGVTSLTAA 237

Query: 198 ERYAPDKTSTVLTRHS--QPATPTPLQSRTSIVQAAAGGVPGGGSNNG------------ 243
             + P  ++ V+   S  +P    P   R S     +G V    S  G            
Sbjct: 238 AAFKPVGSTGVIKSPSWQRPNQGVPSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQ 297

Query: 244 ---------KTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIF 294
                    +TP+C  C++VIRG +LVALG ++HPEEF C+ C   +   GF EEKGA++
Sbjct: 298 RAEHIPAGKRTPMCAHCNQVIRGPFLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALY 357

Query: 295 CPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYC 354
           C  CY+  +AP C +C++KI GE++ ALK TWHV CF C AC  PIRN  F++E+G PYC
Sbjct: 358 CELCYEKFFAPECGRCQRKILGEVISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYC 417

Query: 355 ERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPL 414
           E DY  +FGT CHGC+F I+AGD FLEALG++WHDTCFVC++C  +LEG+TF+SKKD+PL
Sbjct: 418 ETDYYALFGTICHGCEFPIEAGDMFLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPL 477

Query: 415 CKSHAFS 421
           CK HA S
Sbjct: 478 CKKHAHS 484


>gi|197383077 PDZ and LIM domain 5 isoform a [Homo sapiens]
          Length = 596

 Score =  322 bits (826), Expect = 3e-88
 Identities = 161/343 (46%), Positives = 214/343 (62%), Gaps = 28/343 (8%)

Query: 104 PLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKS--SQVPR 161
           P   DASK+RL+E+TEDWRPR GT QSRSFRILA +TGTE +++ + ++ KK+  SQ P 
Sbjct: 254 PTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNTKKANNSQEPS 313

Query: 162 TEAPAPASSTPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPDKTSTVLTRHS--QPATPT 219
            +  +  +ST   P    +  SPTS  P       A  + P  ++ V+   S  +P    
Sbjct: 314 PQLASSVASTRSMP---ESLDSPTSGRPGVTSLTAAAAFKPVGSTGVIKSPSWQRPNQGV 370

Query: 220 PLQSRTSIVQAAAGGVPGGGSNNG---------------------KTPVCHQCHKVIRGR 258
           P   R S     +G V    S  G                     +TP+C  C++VIRG 
Sbjct: 371 PSTGRISNSATYSGSVAPANSALGQTQPSDQDTLVQRAEHIPAGKRTPMCAHCNQVIRGP 430

Query: 259 YLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEI 318
           +LVALG ++HPEEF C+ C   +   GF EEKGA++C  CY+  +AP C +C++KI GE+
Sbjct: 431 FLVALGKSWHPEEFNCAHCKNTMAYIGFVEEKGALYCELCYEKFFAPECGRCQRKILGEV 490

Query: 319 MHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDR 378
           + ALK TWHV CF C AC  PIRN  F++E+G PYCE DY  +FGT CHGC+F I+AGD 
Sbjct: 491 ISALKQTWHVSCFVCVACGKPIRNNVFHLEDGEPYCETDYYALFGTICHGCEFPIEAGDM 550

Query: 379 FLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFS 421
           FLEALG++WHDTCFVC++C  +LEG+TF+SKKD+PLCK HA S
Sbjct: 551 FLEALGYTWHDTCFVCSVCCESLEGQTFFSKKDKPLCKKHAHS 593



 Score =  117 bits (292), Expect = 3e-26
 Identities = 60/107 (56%), Positives = 73/107 (68%), Gaps = 1/107 (0%)

Query: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
           M ++ V L GPAPWGFRLQGGKDFN+PL+IS L  GGKAAQA V +GD VLSIDG NA  
Sbjct: 1   MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60

Query: 61  LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLRPLVP 107
           +TH+EAQNKI+ C   L++ L RA     KP+ V     +P   + P
Sbjct: 61  MTHLEAQNKIKGCTGSLNMTLQRAS-AAPKPEPVPVQKGEPKEVVKP 106


>gi|47157328 PDZ and LIM domain 7 isoform 4 [Homo sapiens]
          Length = 222

 Score =  293 bits (750), Expect = 2e-79
 Identities = 153/201 (76%), Positives = 156/201 (77%), Gaps = 34/201 (16%)

Query: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
           MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS
Sbjct: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60

Query: 61  LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTP----------------------- 97
           LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQK   P                       
Sbjct: 61  LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKASAPAADPPRYTFAPSVSLNKTARPFG 120

Query: 98  -----------DKQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ 146
                      + QPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ
Sbjct: 121 APPPADSAPQQNGQPLRPLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQ 180

Query: 147 DPDEEHLKKSSQVPRTEAPAP 167
           DPDEEHLKKS +    E  +P
Sbjct: 181 DPDEEHLKKSREKYVLELQSP 201


>gi|122056614 LIM domain binding 3 isoform 2 [Homo sapiens]
          Length = 617

 Score =  291 bits (744), Expect = 1e-78
 Identities = 135/276 (48%), Positives = 180/276 (65%), Gaps = 14/276 (5%)

Query: 157 SQVPR-TEAPAPASSTPQEPWPGPTAPS---------PTSRPPWAVDPAFAERYAPDKTS 206
           S VP  T +PAPA +    P   P APS         P SRPPW  D +F++++AP K++
Sbjct: 338 SPVPTYTPSPAPAYTPSPAPNYNP-APSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKST 396

Query: 207 TVLTRHSQP-ATPTPLQSRTSIVQAAAGGVPGGGS--NNGKTPVCHQCHKVIRGRYLVAL 263
           T +++ + P   P    +   +   A G V        + +TP+C  C+ VIRG +LVA+
Sbjct: 397 TSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAM 456

Query: 264 GHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALK 323
           G ++HPEEF C+ C   L +  F EE+  ++C  CY+  +AP CAKC  KI GE+MHAL+
Sbjct: 457 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 516

Query: 324 MTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEAL 383
            TWH  CF CAACK P  N  F+ME+G PYCE+DY  +F TKCHGCDF ++AGD+F+EAL
Sbjct: 517 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEAL 576

Query: 384 GFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHA 419
           G +WHDTCF+CA+C +NLEG+ FYSKKDRPLCK HA
Sbjct: 577 GHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 612



 Score =  114 bits (284), Expect = 2e-25
 Identities = 54/98 (55%), Positives = 73/98 (74%), Gaps = 3/98 (3%)

Query: 3  SFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLT 62
          S+ V L GP PWGFRLQGGKDFN+PL+ISR+TPG KAAQ+ ++ GD V++IDG N  ++T
Sbjct: 2  SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61

Query: 63 HIEAQNKIRACGERLSLGLSRAQ---PVQSKPQKVQTP 97
          H+EAQNKI++    LSL L +++   P+ +    VQTP
Sbjct: 62 HLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTP 99


>gi|45592959 LIM domain binding 3 isoform 1 [Homo sapiens]
          Length = 727

 Score =  291 bits (744), Expect = 1e-78
 Identities = 135/276 (48%), Positives = 180/276 (65%), Gaps = 14/276 (5%)

Query: 157 SQVPR-TEAPAPASSTPQEPWPGPTAPS---------PTSRPPWAVDPAFAERYAPDKTS 206
           S VP  T +PAPA +    P   P APS         P SRPPW  D +F++++AP K++
Sbjct: 448 SPVPTYTPSPAPAYTPSPAPNYNP-APSVAYSGGPAEPASRPPWVTDDSFSQKFAPGKST 506

Query: 207 TVLTRHSQP-ATPTPLQSRTSIVQAAAGGVPGGGS--NNGKTPVCHQCHKVIRGRYLVAL 263
           T +++ + P   P    +   +   A G V        + +TP+C  C+ VIRG +LVA+
Sbjct: 507 TSISKQTLPRGGPAYTPAGPQVPPLARGTVQRAERFPASSRTPLCGHCNNVIRGPFLVAM 566

Query: 264 GHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALK 323
           G ++HPEEF C+ C   L +  F EE+  ++C  CY+  +AP CAKC  KI GE+MHAL+
Sbjct: 567 GRSWHPEEFTCAYCKTSLADVCFVEEQNNVYCERCYEQFFAPLCAKCNTKIMGEVMHALR 626

Query: 324 MTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEAL 383
            TWH  CF CAACK P  N  F+ME+G PYCE+DY  +F TKCHGCDF ++AGD+F+EAL
Sbjct: 627 QTWHTTCFVCAACKKPFGNSLFHMEDGEPYCEKDYINLFSTKCHGCDFPVEAGDKFIEAL 686

Query: 384 GFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHA 419
           G +WHDTCF+CA+C +NLEG+ FYSKKDRPLCK HA
Sbjct: 687 GHTWHDTCFICAVCHVNLEGQPFYSKKDRPLCKKHA 722



 Score =  115 bits (289), Expect = 6e-26
 Identities = 73/184 (39%), Positives = 98/184 (53%), Gaps = 21/184 (11%)

Query: 3   SFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLT 62
           S+ V L GP PWGFRLQGGKDFN+PL+ISR+TPG KAAQ+ ++ GD V++IDG N  ++T
Sbjct: 2   SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61

Query: 63  HIEAQNKIRACGERLSLGLSRAQ---PVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTE 119
           H+EAQNKI++    LSL L +++   P+ +    VQTP      P++P      L  N  
Sbjct: 62  HLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTP-----LPVIPHQKDPALDTNGS 116

Query: 120 DWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGP 179
              P P      S        GT     P    L+ +   P    P+  SS  +   PGP
Sbjct: 117 LVAPSPSPEARAS-------PGT-----PGTPELRPTFS-PAFSRPSAFSSLAEASDPGP 163

Query: 180 TAPS 183
              S
Sbjct: 164 PRAS 167



 Score = 68.6 bits (166), Expect = 1e-11
 Identities = 48/126 (38%), Positives = 59/126 (46%), Gaps = 5/126 (3%)

Query: 110 SKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPAS 169
           S+ +  +  ++W  R    QSRSFRILA +TGTEFMQDPDEE L++SS  P   AP   S
Sbjct: 252 SQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSS-TPIEHAPVCTS 310

Query: 170 STPQEPWPGPTAPSPTSRPPWAVDPAFAERYAPD---KTSTVLTRHSQPATPTPLQSRTS 226
                  P    P P +  P A  P  A   A       ST     S   +P P  S  S
Sbjct: 311 QATTPLLPASAQP-PAAASPSAASPPLATAAAHTAIASASTTAPASSPADSPRPQASSYS 369

Query: 227 IVQAAA 232
              AA+
Sbjct: 370 PAVAAS 375


>gi|58533161 PDZ and LIM domain 5 isoform e [Homo sapiens]
          Length = 214

 Score =  176 bits (446), Expect = 4e-44
 Identities = 97/185 (52%), Positives = 121/185 (65%), Gaps = 27/185 (14%)

Query: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
           M ++ V L GPAPWGFRLQGGKDFN+PL+IS L  GGKAAQA V +GD VLSIDG NA  
Sbjct: 1   MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60

Query: 61  LTHIEAQNKIRACGERLSLGLSRAQ--------PVQSK------PQKVQTPDKQPLR--- 103
           +TH+EAQNKI+ C   L++ L RA         PVQ K      P  V+ P K+P R   
Sbjct: 61  MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKKTQVTNNPGTVKIPPKRPPRKHI 120

Query: 104 ----------PLVPDASKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHL 153
                     P   DASK+RL+E+TEDWRPR GT QSRSFRILA +TGTE +++ + ++ 
Sbjct: 121 VERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSFRILAQITGTEHLKESEADNT 180

Query: 154 KKSSQ 158
           KK+ +
Sbjct: 181 KKAKE 185


>gi|58533159 PDZ and LIM domain 5 isoform d [Homo sapiens]
          Length = 234

 Score =  167 bits (423), Expect = 2e-41
 Identities = 97/205 (47%), Positives = 121/205 (59%), Gaps = 47/205 (22%)

Query: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
           M ++ V L GPAPWGFRLQGGKDFN+PL+IS L  GGKAAQA V +GD VLSIDG NA  
Sbjct: 1   MSNYSVSLVGPAPWGFRLQGGKDFNMPLTISSLKDGGKAAQANVRIGDVVLSIDGINAQG 60

Query: 61  LTHIEAQNKIRACGERLSLGLSRAQ--------PVQ------------------------ 88
           +TH+EAQNKI+ C   L++ L RA         PVQ                        
Sbjct: 61  MTHLEAQNKIKGCTGSLNMTLQRASAAPKPEPVPVQKPTVTSVCSETSQELAEGQRRGSQ 120

Query: 89  --SKPQKVQTPDKQPLR-------------PLVPDASKQRLMENTEDWRPRPGTGQSRSF 133
             SK Q  + P K+P R             P   DASK+RL+E+TEDWRPR GT QSRSF
Sbjct: 121 GDSKQQNGKIPPKRPPRKHIVERYTEFYHVPTHSDASKKRLIEDTEDWRPRTGTTQSRSF 180

Query: 134 RILAHLTGTEFMQDPDEEHLKKSSQ 158
           RILA +TGTE +++ + ++ KK+ +
Sbjct: 181 RILAQITGTEHLKESEADNTKKAKE 205


>gi|109638745 transforming growth factor beta 1 induced transcript 1
           isoform 1 [Homo sapiens]
          Length = 461

 Score =  165 bits (417), Expect = 8e-41
 Identities = 103/317 (32%), Positives = 143/317 (45%), Gaps = 31/317 (9%)

Query: 126 GTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPAS------STPQEPWPGP 179
           GTG     R+L  L  T+F    +      SS+V   E     S      S P  P PG 
Sbjct: 87  GTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGL 146

Query: 180 TAPSPTS------RPPWAVDPAFAERYAPDKTSTV-----LTRHSQPATPTP-----LQS 223
              S TS      R   ++     + + P    T       T    P+ P P     L +
Sbjct: 147 PKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDT 206

Query: 224 RTSIVQA--AAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVL 281
              ++Q+  +  GVP          +C  C+K I G+ + ALG A+HPE FVC  C   L
Sbjct: 207 MLGLLQSDLSRRGVPTQAKG-----LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTAL 261

Query: 282 EEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIR 341
               FFE+ GA FCP CY  R++P C  C + I  +++ AL   WH   F C +C  P  
Sbjct: 262 GGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFG 321

Query: 342 NRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINL 401
           +  F+  EG PYC RD+ ++F  +C GC   I   D ++ AL   WH  CFVC  C    
Sbjct: 322 DEGFHEREGRPYCRRDFLQLFAPRCQGCQGPI--LDNYISALSALWHPDCFVCRECFAPF 379

Query: 402 EGKTFYSKKDRPLCKSH 418
            G +F+  + RPLC++H
Sbjct: 380 SGGSFFEHEGRPLCENH 396



 Score =  112 bits (280), Expect = 6e-25
 Identities = 55/172 (31%), Positives = 80/172 (46%), Gaps = 2/172 (1%)

Query: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           +P C  C++ IR + + ALG  +HPE F C  CG+   + GF E +G  +C   +   +A
Sbjct: 284 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 343

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGT 364
           P C  C+  I    + AL   WH  CF C  C  P    +F+  EG P CE  +    G+
Sbjct: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403

Query: 365 KCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
            C  C   +    R + ALG  +H   F C  C   L   +F  +  +P C+
Sbjct: 404 LCATCGLPVTG--RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQ 453



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 41/118 (34%), Positives = 55/118 (46%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P C  C   I   Y+ AL   +HP+ FVC +C      G FFE +G   C   +  R   
Sbjct: 344 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 403

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFG 363
            CA C   +TG  + AL   +H   FTC  C  P+   +F    G PYC+  + K+FG
Sbjct: 404 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 461


>gi|21361591 transforming growth factor beta 1 induced transcript 1
           isoform 2 [Homo sapiens]
          Length = 444

 Score =  165 bits (417), Expect = 8e-41
 Identities = 103/317 (32%), Positives = 143/317 (45%), Gaps = 31/317 (9%)

Query: 126 GTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPAS------STPQEPWPGP 179
           GTG     R+L  L  T+F    +      SS+V   E     S      S P  P PG 
Sbjct: 70  GTGLCELDRLLQELNATQFNITDEIMSQFPSSKVASGEQKEDQSEDKKRPSLPSSPSPGL 129

Query: 180 TAPSPTS------RPPWAVDPAFAERYAPDKTSTV-----LTRHSQPATPTP-----LQS 223
              S TS      R   ++     + + P    T       T    P+ P P     L +
Sbjct: 130 PKASATSATLELDRLMASLSDFRVQNHLPASGPTQPPVVSSTNEGSPSPPEPTGKGSLDT 189

Query: 224 RTSIVQA--AAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVL 281
              ++Q+  +  GVP          +C  C+K I G+ + ALG A+HPE FVC  C   L
Sbjct: 190 MLGLLQSDLSRRGVPTQAKG-----LCGSCNKPIAGQVVTALGRAWHPEHFVCGGCSTAL 244

Query: 282 EEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIR 341
               FFE+ GA FCP CY  R++P C  C + I  +++ AL   WH   F C +C  P  
Sbjct: 245 GGSSFFEKDGAPFCPECYFERFSPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFG 304

Query: 342 NRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINL 401
           +  F+  EG PYC RD+ ++F  +C GC   I   D ++ AL   WH  CFVC  C    
Sbjct: 305 DEGFHEREGRPYCRRDFLQLFAPRCQGCQGPI--LDNYISALSALWHPDCFVCRECFAPF 362

Query: 402 EGKTFYSKKDRPLCKSH 418
            G +F+  + RPLC++H
Sbjct: 363 SGGSFFEHEGRPLCENH 379



 Score =  112 bits (280), Expect = 6e-25
 Identities = 55/172 (31%), Positives = 80/172 (46%), Gaps = 2/172 (1%)

Query: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           +P C  C++ IR + + ALG  +HPE F C  CG+   + GF E +G  +C   +   +A
Sbjct: 267 SPRCGFCNQPIRHKMVTALGTHWHPEHFCCVSCGEPFGDEGFHEREGRPYCRRDFLQLFA 326

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGT 364
           P C  C+  I    + AL   WH  CF C  C  P    +F+  EG P CE  +    G+
Sbjct: 327 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 386

Query: 365 KCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
            C  C   +    R + ALG  +H   F C  C   L   +F  +  +P C+
Sbjct: 387 LCATCGLPVTG--RCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQ 436



 Score = 84.7 bits (208), Expect = 1e-16
 Identities = 41/118 (34%), Positives = 55/118 (46%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P C  C   I   Y+ AL   +HP+ FVC +C      G FFE +G   C   +  R   
Sbjct: 327 PRCQGCQGPILDNYISALSALWHPDCFVCRECFAPFSGGSFFEHEGRPLCENHFHARRGS 386

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFG 363
            CA C   +TG  + AL   +H   FTC  C  P+   +F    G PYC+  + K+FG
Sbjct: 387 LCATCGLPVTGRCVSALGRRFHPDHFTCTFCLRPLTKGSFQERAGKPYCQPCFLKLFG 444


>gi|221316659 leupaxin isoform 1 [Homo sapiens]
          Length = 391

 Score =  135 bits (339), Expect = 9e-32
 Identities = 59/171 (34%), Positives = 88/171 (51%), Gaps = 2/171 (1%)

Query: 248 CHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSC 307
           C  C K I G+ + ALG ++HPE FVC+ C + +    FFE  G  +CP  Y   ++P C
Sbjct: 157 CASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRC 216

Query: 308 AKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCH 367
           A C   I  +++ A+  TWH   F C+ C        F+ ++  PYC +D+  MF  KC 
Sbjct: 217 AYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCG 276

Query: 368 GCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 418
           GC+  +   + +L A+   WH  CFVC  C  +    +F+    RP C+ H
Sbjct: 277 GCNRPV--LENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELH 325



 Score =  122 bits (306), Expect = 6e-28
 Identities = 56/172 (32%), Positives = 81/172 (47%), Gaps = 2/172 (1%)

Query: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           +P C  C   I  + L A+   +HPE F CS CG+V    GF E+    +C   +   ++
Sbjct: 213 SPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 272

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGT 364
           P C  C + +    + A+   WH  CF C  C T     +F+  +G P+CE  Y    GT
Sbjct: 273 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 332

Query: 365 KCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
            CHGC   I    R + A+G+ +H   FVCA C   L    F  + D+  C+
Sbjct: 333 LCHGCGQPITG--RCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQ 382



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 39/118 (33%), Positives = 54/118 (45%)

Query: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           +P C  C++ +   YL A+   +HPE FVC  C      G FFE  G  FC   Y  R  
Sbjct: 272 SPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRG 331

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMF 362
             C  C + ITG  + A+   +H   F CA C T +    F  +    YC+  + K+F
Sbjct: 332 TLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 389


>gi|4758670 leupaxin isoform 2 [Homo sapiens]
          Length = 386

 Score =  135 bits (339), Expect = 9e-32
 Identities = 59/171 (34%), Positives = 88/171 (51%), Gaps = 2/171 (1%)

Query: 248 CHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSC 307
           C  C K I G+ + ALG ++HPE FVC+ C + +    FFE  G  +CP  Y   ++P C
Sbjct: 152 CASCQKPIAGKVIHALGQSWHPEHFVCTHCKEEIGSSPFFERSGLAYCPNDYHQLFSPRC 211

Query: 308 AKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCH 367
           A C   I  +++ A+  TWH   F C+ C        F+ ++  PYC +D+  MF  KC 
Sbjct: 212 AYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFSPKCG 271

Query: 368 GCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 418
           GC+  +   + +L A+   WH  CFVC  C  +    +F+    RP C+ H
Sbjct: 272 GCNRPV--LENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELH 320



 Score =  122 bits (306), Expect = 6e-28
 Identities = 56/172 (32%), Positives = 81/172 (47%), Gaps = 2/172 (1%)

Query: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           +P C  C   I  + L A+   +HPE F CS CG+V    GF E+    +C   +   ++
Sbjct: 208 SPRCAYCAAPILDKVLTAMNQTWHPEHFFCSHCGEVFGAEGFHEKDKKPYCRKDFLAMFS 267

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGT 364
           P C  C + +    + A+   WH  CF C  C T     +F+  +G P+CE  Y    GT
Sbjct: 268 PKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRGT 327

Query: 365 KCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
            CHGC   I    R + A+G+ +H   FVCA C   L    F  + D+  C+
Sbjct: 328 LCHGCGQPITG--RCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQ 377



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 39/118 (33%), Positives = 54/118 (45%)

Query: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           +P C  C++ +   YL A+   +HPE FVC  C      G FFE  G  FC   Y  R  
Sbjct: 267 SPKCGGCNRPVLENYLSAMDTVWHPECFVCGDCFTSFSTGSFFELDGRPFCELHYHHRRG 326

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMF 362
             C  C + ITG  + A+   +H   F CA C T +    F  +    YC+  + K+F
Sbjct: 327 TLCHGCGQPITGRCISAMGYKFHPEHFVCAFCLTQLSKGIFREQNDKTYCQPCFNKLF 384


>gi|170932518 paxillin isoform 3 [Homo sapiens]
          Length = 424

 Score =  131 bits (330), Expect = 1e-30
 Identities = 62/173 (35%), Positives = 86/173 (49%), Gaps = 2/173 (1%)

Query: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           +P C+ C+  I  + + AL   +HPE F C+QCG      GF E+ G  +C   Y   +A
Sbjct: 247 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 306

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGT 364
           P C  C + I    + AL   WH  CF C  C TP  N +F+  +G PYCE  Y +  G+
Sbjct: 307 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 366

Query: 365 KCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKS 417
            C GC   I    R + A+   +H   FVCA C   L   TF  + D+P C++
Sbjct: 367 LCSGCQKPITG--RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQN 417



 Score =  127 bits (318), Expect = 2e-29
 Identities = 60/172 (34%), Positives = 84/172 (48%), Gaps = 2/172 (1%)

Query: 247 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 306
           VC  C K I G+ + A+G  +HPE FVC+ C + +    FFE  G  +C   Y   ++P 
Sbjct: 190 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 249

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  C   I  +++ AL  TWH   F CA C        F+ ++G  YC +DY  MF  KC
Sbjct: 250 CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKC 309

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 418
            GC   I   + ++ AL   WH  CFVC  C       +F+    +P C+ H
Sbjct: 310 GGCARAI--LENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVH 359



 Score = 89.0 bits (219), Expect = 8e-18
 Identities = 40/114 (35%), Positives = 60/114 (52%), Gaps = 2/114 (1%)

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  CKK I G+++ A+  TWH   F C  C+  I +R F+  +G PYCE+DY  +F  +C
Sbjct: 191 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRC 250

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAF 420
           + C+  I   D+ + AL  +WH   F CA C      + F+ K  +  C+   F
Sbjct: 251 YYCNGPIL--DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYF 302



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 40/117 (34%), Positives = 55/117 (47%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P C  C + I   Y+ AL   +HPE FVC +C      G FFE  G  +C   Y  R   
Sbjct: 307 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 366

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMF 362
            C+ C+K ITG  + A+   +H   F CA C   +    F  +   PYC+  + K+F
Sbjct: 367 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 423


>gi|170932516 paxillin isoform 2 [Homo sapiens]
          Length = 557

 Score =  131 bits (330), Expect = 1e-30
 Identities = 62/173 (35%), Positives = 86/173 (49%), Gaps = 2/173 (1%)

Query: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           +P C+ C+  I  + + AL   +HPE F C+QCG      GF E+ G  +C   Y   +A
Sbjct: 380 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 439

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGT 364
           P C  C + I    + AL   WH  CF C  C TP  N +F+  +G PYCE  Y +  G+
Sbjct: 440 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 499

Query: 365 KCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKS 417
            C GC   I    R + A+   +H   FVCA C   L   TF  + D+P C++
Sbjct: 500 LCSGCQKPITG--RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQN 550



 Score =  127 bits (318), Expect = 2e-29
 Identities = 60/172 (34%), Positives = 84/172 (48%), Gaps = 2/172 (1%)

Query: 247 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 306
           VC  C K I G+ + A+G  +HPE FVC+ C + +    FFE  G  +C   Y   ++P 
Sbjct: 323 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 382

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  C   I  +++ AL  TWH   F CA C        F+ ++G  YC +DY  MF  KC
Sbjct: 383 CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKC 442

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 418
            GC   I   + ++ AL   WH  CFVC  C       +F+    +P C+ H
Sbjct: 443 GGCARAI--LENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVH 492



 Score = 89.0 bits (219), Expect = 8e-18
 Identities = 40/114 (35%), Positives = 60/114 (52%), Gaps = 2/114 (1%)

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  CKK I G+++ A+  TWH   F C  C+  I +R F+  +G PYCE+DY  +F  +C
Sbjct: 324 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRC 383

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAF 420
           + C+  I   D+ + AL  +WH   F CA C      + F+ K  +  C+   F
Sbjct: 384 YYCNGPIL--DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYF 435



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 40/117 (34%), Positives = 55/117 (47%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P C  C + I   Y+ AL   +HPE FVC +C      G FFE  G  +C   Y  R   
Sbjct: 440 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 499

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMF 362
            C+ C+K ITG  + A+   +H   F CA C   +    F  +   PYC+  + K+F
Sbjct: 500 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 556


>gi|170932514 paxillin isoform 1 [Homo sapiens]
          Length = 591

 Score =  131 bits (330), Expect = 1e-30
 Identities = 62/173 (35%), Positives = 86/173 (49%), Gaps = 2/173 (1%)

Query: 245 TPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           +P C+ C+  I  + + AL   +HPE F C+QCG      GF E+ G  +C   Y   +A
Sbjct: 414 SPRCYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFA 473

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGT 364
           P C  C + I    + AL   WH  CF C  C TP  N +F+  +G PYCE  Y +  G+
Sbjct: 474 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 533

Query: 365 KCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKS 417
            C GC   I    R + A+   +H   FVCA C   L   TF  + D+P C++
Sbjct: 534 LCSGCQKPITG--RCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQN 584



 Score =  127 bits (318), Expect = 2e-29
 Identities = 60/172 (34%), Positives = 84/172 (48%), Gaps = 2/172 (1%)

Query: 247 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 306
           VC  C K I G+ + A+G  +HPE FVC+ C + +    FFE  G  +C   Y   ++P 
Sbjct: 357 VCGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPR 416

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  C   I  +++ AL  TWH   F CA C        F+ ++G  YC +DY  MF  KC
Sbjct: 417 CYYCNGPILDKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYFDMFAPKC 476

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 418
            GC   I   + ++ AL   WH  CFVC  C       +F+    +P C+ H
Sbjct: 477 GGCARAI--LENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVH 526



 Score = 89.0 bits (219), Expect = 8e-18
 Identities = 40/114 (35%), Positives = 60/114 (52%), Gaps = 2/114 (1%)

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  CKK I G+++ A+  TWH   F C  C+  I +R F+  +G PYCE+DY  +F  +C
Sbjct: 358 CGACKKPIAGQVVTAMGKTWHPEHFVCTHCQEEIGSRNFFERDGQPYCEKDYHNLFSPRC 417

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSHAF 420
           + C+  I   D+ + AL  +WH   F CA C      + F+ K  +  C+   F
Sbjct: 418 YYCNGPIL--DKVVTALDRTWHPEHFFCAQCGAFFGPEGFHEKDGKAYCRKDYF 469



 Score = 83.2 bits (204), Expect = 4e-16
 Identities = 40/117 (34%), Positives = 55/117 (47%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P C  C + I   Y+ AL   +HPE FVC +C      G FFE  G  +C   Y  R   
Sbjct: 474 PKCGGCARAILENYISALNTLWHPECFVCRECFTPFVNGSFFEHDGQPYCEVHYHERRGS 533

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMF 362
            C+ C+K ITG  + A+   +H   F CA C   +    F  +   PYC+  + K+F
Sbjct: 534 LCSGCQKPITGRCITAMAKKFHPEHFVCAFCLKQLNKGTFKEQNDKPYCQNCFLKLF 590


>gi|238859658 LIM and senescent cell antigen-like domains 2 isoform
           1 [Homo sapiens]
          Length = 363

 Score =  131 bits (329), Expect = 1e-30
 Identities = 64/171 (37%), Positives = 94/171 (54%), Gaps = 4/171 (2%)

Query: 247 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 306
           +C +CH VI  + L+    AYHP+ F C+ CGK L      E KG ++C PC+D    P 
Sbjct: 161 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 219

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  C++ I G +++AL   WHV  F CA C+ P      Y ++G+ YCE  Y ++FG  C
Sbjct: 220 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 279

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKD-RPLCK 416
           + C   I+ GD  + AL  +W  +CF C+ C   L  K  + + D +P+CK
Sbjct: 280 YNCSHVIE-GD-VVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 328



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 40/116 (34%), Positives = 63/116 (54%), Gaps = 1/116 (0%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P+C  C + I GR + ALG  +H E FVC++C K       +E+KG  +C   Y+  +  
Sbjct: 218 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 277

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYME-EGVPYCERDYEK 360
            C  C   I G+++ AL   W V CF+C+ C + +  +  ++E +  P C+R YEK
Sbjct: 278 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 333



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 46/158 (29%), Positives = 68/158 (43%), Gaps = 9/158 (5%)

Query: 247 VCHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           VC +C        R + + G  YH   FVC+QC +   EG F+E +G  +C   + + +A
Sbjct: 36  VCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFA 95

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYC----ERDYEK 360
           P C  C + I G ++ A+   WH  CF C  C   + +  F    G   C     R+  K
Sbjct: 96  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 155

Query: 361 MFGTK-CHGCDFKIDAGDRFLEALGFSWHDTCFVCAIC 397
             G   C  C   ID  ++ L     ++H   F C  C
Sbjct: 156 GLGKYICQRCHLVID--EQPLMFRSDAYHPDHFNCTHC 191



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 15/51 (29%), Positives = 23/51 (45%)

Query: 366 CHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
           C  C  +    +R + + G  +H+ CFVCA C        FY  + R  C+
Sbjct: 37  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 87


>gi|238776788 LIM and senescent cell antigen-like domains 2 isoform
           5 [Homo sapiens]
          Length = 336

 Score =  131 bits (329), Expect = 1e-30
 Identities = 64/171 (37%), Positives = 94/171 (54%), Gaps = 4/171 (2%)

Query: 247 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 306
           +C +CH VI  + L+    AYHP+ F C+ CGK L      E KG ++C PC+D    P 
Sbjct: 134 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 192

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  C++ I G +++AL   WHV  F CA C+ P      Y ++G+ YCE  Y ++FG  C
Sbjct: 193 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 252

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKD-RPLCK 416
           + C   I+ GD  + AL  +W  +CF C+ C   L  K  + + D +P+CK
Sbjct: 253 YNCSHVIE-GD-VVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 301



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 40/116 (34%), Positives = 63/116 (54%), Gaps = 1/116 (0%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P+C  C + I GR + ALG  +H E FVC++C K       +E+KG  +C   Y+  +  
Sbjct: 191 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 250

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYME-EGVPYCERDYEK 360
            C  C   I G+++ AL   W V CF+C+ C + +  +  ++E +  P C+R YEK
Sbjct: 251 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 306



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 46/158 (29%), Positives = 68/158 (43%), Gaps = 9/158 (5%)

Query: 247 VCHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           VC +C        R + + G  YH   FVC+QC +   EG F+E +G  +C   + + +A
Sbjct: 9   VCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFA 68

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYC----ERDYEK 360
           P C  C + I G ++ A+   WH  CF C  C   + +  F    G   C     R+  K
Sbjct: 69  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 128

Query: 361 MFGTK-CHGCDFKIDAGDRFLEALGFSWHDTCFVCAIC 397
             G   C  C   ID  ++ L     ++H   F C  C
Sbjct: 129 GLGKYICQRCHLVID--EQPLMFRSDAYHPDHFNCTHC 164



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 15/51 (29%), Positives = 23/51 (45%)

Query: 366 CHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
           C  C  +    +R + + G  +H+ CFVCA C        FY  + R  C+
Sbjct: 10  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 60


>gi|238776786 LIM and senescent cell antigen-like domains 2 isoform
           3 [Homo sapiens]
          Length = 341

 Score =  131 bits (329), Expect = 1e-30
 Identities = 64/171 (37%), Positives = 94/171 (54%), Gaps = 4/171 (2%)

Query: 247 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 306
           +C +CH VI  + L+    AYHP+ F C+ CGK L      E KG ++C PC+D    P 
Sbjct: 139 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 197

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  C++ I G +++AL   WHV  F CA C+ P      Y ++G+ YCE  Y ++FG  C
Sbjct: 198 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 257

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKD-RPLCK 416
           + C   I+ GD  + AL  +W  +CF C+ C   L  K  + + D +P+CK
Sbjct: 258 YNCSHVIE-GD-VVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 306



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 40/116 (34%), Positives = 63/116 (54%), Gaps = 1/116 (0%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P+C  C + I GR + ALG  +H E FVC++C K       +E+KG  +C   Y+  +  
Sbjct: 196 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 255

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYME-EGVPYCERDYEK 360
            C  C   I G+++ AL   W V CF+C+ C + +  +  ++E +  P C+R YEK
Sbjct: 256 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 311



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 46/158 (29%), Positives = 68/158 (43%), Gaps = 9/158 (5%)

Query: 247 VCHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           VC +C        R + + G  YH   FVC+QC +   EG F+E +G  +C   + + +A
Sbjct: 14  VCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFA 73

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYC----ERDYEK 360
           P C  C + I G ++ A+   WH  CF C  C   + +  F    G   C     R+  K
Sbjct: 74  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 133

Query: 361 MFGTK-CHGCDFKIDAGDRFLEALGFSWHDTCFVCAIC 397
             G   C  C   ID  ++ L     ++H   F C  C
Sbjct: 134 GLGKYICQRCHLVID--EQPLMFRSDAYHPDHFNCTHC 169



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 15/51 (29%), Positives = 23/51 (45%)

Query: 366 CHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
           C  C  +    +R + + G  +H+ CFVCA C        FY  + R  C+
Sbjct: 15  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 65


>gi|40804748 LIM and senescent cell antigen-like domains 2 isoform 2
           [Homo sapiens]
          Length = 365

 Score =  131 bits (329), Expect = 1e-30
 Identities = 64/171 (37%), Positives = 94/171 (54%), Gaps = 4/171 (2%)

Query: 247 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 306
           +C +CH VI  + L+    AYHP+ F C+ CGK L      E KG ++C PC+D    P 
Sbjct: 163 ICQRCHLVIDEQPLMFRSDAYHPDHFNCTHCGKELTAEAR-ELKGELYCLPCHDKMGVPI 221

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  C++ I G +++AL   WHV  F CA C+ P      Y ++G+ YCE  Y ++FG  C
Sbjct: 222 CGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGDVC 281

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKD-RPLCK 416
           + C   I+ GD  + AL  +W  +CF C+ C   L  K  + + D +P+CK
Sbjct: 282 YNCSHVIE-GD-VVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCK 330



 Score = 87.8 bits (216), Expect = 2e-17
 Identities = 40/116 (34%), Positives = 63/116 (54%), Gaps = 1/116 (0%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P+C  C + I GR + ALG  +H E FVC++C K       +E+KG  +C   Y+  +  
Sbjct: 220 PICGACRRPIEGRVVNALGKQWHVEHFVCAKCEKPFLGHRHYEKKGLAYCETHYNQLFGD 279

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYME-EGVPYCERDYEK 360
            C  C   I G+++ AL   W V CF+C+ C + +  +  ++E +  P C+R YEK
Sbjct: 280 VCYNCSHVIEGDVVSALNKAWCVSCFSCSTCNSKLTLKNKFVEFDMKPVCKRCYEK 335



 Score = 75.9 bits (185), Expect = 7e-14
 Identities = 46/158 (29%), Positives = 68/158 (43%), Gaps = 9/158 (5%)

Query: 247 VCHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYA 304
           VC +C        R + + G  YH   FVC+QC +   EG F+E +G  +C   + + +A
Sbjct: 38  VCQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCEHDFQMLFA 97

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYC----ERDYEK 360
           P C  C + I G ++ A+   WH  CF C  C   + +  F    G   C     R+  K
Sbjct: 98  PCCGSCGEFIIGRVIKAMNNNWHPGCFRCELCDVELADLGFVKNAGRHLCRPCHNREKAK 157

Query: 361 MFGTK-CHGCDFKIDAGDRFLEALGFSWHDTCFVCAIC 397
             G   C  C   ID  ++ L     ++H   F C  C
Sbjct: 158 GLGKYICQRCHLVID--EQPLMFRSDAYHPDHFNCTHC 193



 Score = 35.0 bits (79), Expect = 0.13
 Identities = 15/51 (29%), Positives = 23/51 (45%)

Query: 366 CHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
           C  C  +    +R + + G  +H+ CFVCA C        FY  + R  C+
Sbjct: 39  CQRCQARFSPAERIVNSNGELYHEHCFVCAQCFRPFPEGLFYEFEGRKYCE 89


>gi|13518026 LIM and senescent cell antigen-like domains 1 [Homo
           sapiens]
          Length = 325

 Score =  127 bits (320), Expect = 1e-29
 Identities = 60/171 (35%), Positives = 91/171 (53%), Gaps = 4/171 (2%)

Query: 247 VCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPS 306
           +C +CH +I  + L+     YHP+ F C+ CGK L      E KG ++C PC+D    P 
Sbjct: 134 ICQKCHAIIDEQPLIFKNDPYHPDHFNCANCGKELTADAR-ELKGELYCLPCHDKMGVPI 192

Query: 307 CAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKC 366
           C  C++ I G +++A+   WHV  F CA C+ P      Y  +G+ YCE  Y ++FG  C
Sbjct: 193 CGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGDVC 252

Query: 367 HGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKD-RPLCK 416
             C+ ++  GD  + AL  +W   CF C+ C   L  K  + + D +P+CK
Sbjct: 253 FHCN-RVIEGD-VVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCK 301



 Score = 88.2 bits (217), Expect = 1e-17
 Identities = 39/116 (33%), Positives = 63/116 (54%), Gaps = 1/116 (0%)

Query: 246 PVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           P+C  C + I GR + A+G  +H E FVC++C K       +E KG  +C   Y+  +  
Sbjct: 191 PICGACRRPIEGRVVNAMGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETHYNQLFGD 250

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYME-EGVPYCERDYEK 360
            C  C + I G+++ AL   W V+CF C+ C T +  +  ++E +  P C++ YEK
Sbjct: 251 VCFHCNRVIEGDVVSALNKAWCVNCFACSTCNTKLTLKNKFVEFDMKPVCKKCYEK 306



 Score = 79.7 bits (195), Expect = 5e-15
 Identities = 53/216 (24%), Positives = 79/216 (36%), Gaps = 61/216 (28%)

Query: 264 GHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALK 323
           G  YH + FVC+QC +   EG F+E +G  +C   + + +AP C +C + I G ++ A+ 
Sbjct: 28  GELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCEHDFQMLFAPCCHQCGEFIIGRVIKAMN 87

Query: 324 MTWHVHCFTCAACKTPIRNRAFYMEEGVPYCE--------RDYEKMFGTKCH-------- 367
            +WH  CF C  C+  + +  F    G   C         R   K    KCH        
Sbjct: 88  NSWHPECFRCDLCQEVLADIGFVKNAGRHLCRPCHNREKARGLGKYICQKCHAIIDEQPL 147

Query: 368 -----------------GCDFKIDAGD----------------------------RFLEA 382
                            G +   DA +                            R + A
Sbjct: 148 IFKNDPYHPDHFNCANCGKELTADARELKGELYCLPCHDKMGVPICGACRRPIEGRVVNA 207

Query: 383 LGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCKSH 418
           +G  WH   FVCA C+    G   Y +K    C++H
Sbjct: 208 MGKQWHVEHFVCAKCEKPFLGHRHYERKGLAYCETH 243



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 14/51 (27%), Positives = 22/51 (43%)

Query: 366 CHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
           C  C       ++ + + G  +H+ CFVCA C        FY  + R  C+
Sbjct: 10  CERCKGGFAPAEKIVNSNGELYHEQCFVCAQCFQQFPEGLFYEFEGRKYCE 60


>gi|13994151 PDZ and LIM domain 1 [Homo sapiens]
          Length = 329

 Score =  123 bits (308), Expect = 4e-28
 Identities = 92/315 (29%), Positives = 142/315 (45%), Gaps = 28/315 (8%)

Query: 1   MDSFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGS 60
           M + ++ L+GP PWGFRL GGKDF  PL+ISR+TPG KAA A + +GD + +IDGEN  +
Sbjct: 1   MTTQQIDLQGPGPWGFRLVGGKDFEQPLAISRVTPGSKAALANLCIGDVITAIDGENTSN 60

Query: 61  LTHIEAQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLRPLVPDASKQRL-MENTE 119
           +TH+EAQN+I+ C + L+L ++R++     P   +   + P +  +    ++ L + +  
Sbjct: 61  MTHLEAQNRIKGCTDNLTLTVARSEHKVWSPLVTEEGKRHPYKMNLASEPQEVLHIGSAH 120

Query: 120 DWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPR----TEAPAPASSTPQEP 175
           +    P T    S      +T     Q  +   L  S  +       E+   AS      
Sbjct: 121 NRSAMPFTASPASSTTARVITN----QYNNPAGLYSSENISNFNNALESKTAASGVEANS 176

Query: 176 WPGPTAPSPTS------RPPWAVDPAFAERYAPDKTSTVL---------TRHSQPATPTP 220
            P   A  P+S         + +     E   P K ST                P  P+ 
Sbjct: 177 RPLDHAQPPSSLVIDKESEVYKMLQEKQELNEPPKQSTSFLVLQEILESEEKGDPNKPSG 236

Query: 221 LQSRTSIVQAAAGGVPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKV 280
            +S    V+A    V     N  K P+C +C   I G ++       HPE +VC+ CG  
Sbjct: 237 FRS----VKAPVTKVAASIGNAQKLPMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTN 292

Query: 281 LEEGGFFEEKGAIFC 295
           L++ G F  +  I+C
Sbjct: 293 LKQKGHFFVEDQIYC 307



 Score = 36.6 bits (83), Expect = 0.044
 Identities = 15/52 (28%), Positives = 22/52 (42%)

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCER 356
           P C KC   I G  +       H  C+ C  C T ++ +  +  E   YCE+
Sbjct: 258 PMCDKCGTGIVGVFVKLRDRHRHPECYVCTDCGTNLKQKGHFFVEDQIYCEK 309



 Score = 32.0 bits (71), Expect = 1.1
 Identities = 13/36 (36%), Positives = 19/36 (52%)

Query: 388 HDTCFVCAICQINLEGKTFYSKKDRPLCKSHAFSHV 423
           H  C+VC  C  NL+ K  +  +D+  C+ HA   V
Sbjct: 280 HPECYVCTDCGTNLKQKGHFFVEDQIYCEKHARERV 315


>gi|19923181 PDZ and LIM domain 4 isoform 1 [Homo sapiens]
          Length = 330

 Score =  122 bits (305), Expect = 8e-28
 Identities = 104/333 (31%), Positives = 147/333 (44%), Gaps = 58/333 (17%)

Query: 6   VVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIE 65
           V L GP+PWGFRL GG+DF+ PL+ISR+  G KAA A +  GD + +I+GE+   +TH+E
Sbjct: 5   VTLRGPSPWGFRLVGGRDFSAPLTISRVHAGSKAALAALCPGDLIQAINGESTELMTHLE 64

Query: 66  AQNKIRACGERLSLGLSRAQ----PVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTEDW 121
           AQN+I+ C + L+L +SR +    P      K Q   +  + P + D S       T   
Sbjct: 65  AQNRIKGCHDHLTLSVSRPEGRSWPSAPDDSKAQA-HRIHIDPEIQDGSP------TTSR 117

Query: 122 RPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGPTA 181
           RP  GTG           TG E   D          Q PR   P P + + +   P   +
Sbjct: 118 RP-SGTG-----------TGPE---DGRPSLGSPYGQPPR--FPVPHNGSSEATLPAQMS 160

Query: 182 PSPTSRPPWAVDPAFAERYAPD-------KTSTVLTRHSQPATPTPLQSRT-----SIVQ 229
               S PP + DPA     + D       +   +L   ++P    P QS +      +++
Sbjct: 161 TLHVSPPP-SADPARGLPRSRDCRVDLGSEVYRMLREPAEPVAAEPKQSGSFRYLQGMLE 219

Query: 230 AAAGG---VPGGGSNNGKT--------------PVCHQCHKVIRGRYLVALGHAYHPEEF 272
           A  GG    PGG  N   T              P C +C   I G  + A    YHPE F
Sbjct: 220 AGEGGDWPGPGGPRNLKPTASKLGAPLSGLQGLPECTRCGHGIVGTIVKARDKLYHPECF 279

Query: 273 VCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           +CS CG  L++ G+F     ++C      R  P
Sbjct: 280 MCSDCGLNLKQRGYFFLDERLYCESHAKARVKP 312



 Score = 37.0 bits (84), Expect = 0.034
 Identities = 21/75 (28%), Positives = 37/75 (49%), Gaps = 14/75 (18%)

Query: 349 EGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYS 408
           +G+P C R    + GT        + A D+        +H  CF+C+ C +NL+ + ++ 
Sbjct: 250 QGLPECTRCGHGIVGTI-------VKARDKL-------YHPECFMCSDCGLNLKQRGYFF 295

Query: 409 KKDRPLCKSHAFSHV 423
             +R  C+SHA + V
Sbjct: 296 LDERLYCESHAKARV 310


>gi|166235178 PDZ and LIM domain protein 3 isoform b [Homo sapiens]
          Length = 316

 Score =  119 bits (297), Expect = 7e-27
 Identities = 89/301 (29%), Positives = 134/301 (44%), Gaps = 23/301 (7%)

Query: 6   VVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLTHIE 65
           V+L GPAPWGFRL GG DFN PL I+R+TPG KAA A +  GD +L+IDG    S+TH +
Sbjct: 5   VILPGPAPWGFRLSGGIDFNQPLVITRITPGSKAAAANLCPGDVILAIDGFGTESMTHAD 64

Query: 66  AQNKIRACGERLSLGLSRAQPVQSKPQKVQTPDKQPLR-PLVPDASKQRLMENTEDWRPR 124
           AQ++I+A   +L L + R +     PQ  +     P +  L  +  + + +    + R +
Sbjct: 65  AQDRIKAAAHQLCLKIDRGETHLWSPQVSEDGKAHPFKINLESEPQEFKPIGTAHNRRAQ 124

Query: 125 PGTGQ----------SRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQE 174
           P              S S+     L  T  +QD     L+    +P +    P +S P E
Sbjct: 125 PFVAAANIDDKRQVVSASYNSPIGLYSTSNIQDALHGQLR--GLIPSSPQNEPTASVPPE 182

Query: 175 PWPGPTAPSPTSRPPWAVDPAFAERYAPDKTSTVLTRHSQPATPTPLQSRTSIVQAAAGG 234
                      + P     P  +  +   +         +PA        T  V+A    
Sbjct: 183 SDVYRMLHDNRNEP---TQPRQSGSFRVLQGMVDDGSDDRPA-------GTRSVRAPVTK 232

Query: 235 VPGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIF 294
           V GG     + P+C +C   I G  + A     HPE FVC+ C   L++ G+F  +G ++
Sbjct: 233 VHGGSGGAQRMPLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFIEGELY 292

Query: 295 C 295
           C
Sbjct: 293 C 293



 Score = 44.3 bits (103), Expect = 2e-04
 Identities = 18/51 (35%), Positives = 25/51 (49%)

Query: 305 PSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCE 355
           P C KC   I G ++ A     H  CF CA C   ++ + ++  EG  YCE
Sbjct: 244 PLCDKCGSGIVGAVVKARDKYRHPECFVCADCNLNLKQKGYFFIEGELYCE 294



 Score = 34.7 bits (78), Expect = 0.17
 Identities = 13/32 (40%), Positives = 20/32 (62%)

Query: 388 HDTCFVCAICQINLEGKTFYSKKDRPLCKSHA 419
           H  CFVCA C +NL+ K ++  +    C++HA
Sbjct: 266 HPECFVCADCNLNLKQKGYFFIEGELYCETHA 297


>gi|122056617 LIM domain binding 3 isoform 3 [Homo sapiens]
          Length = 330

 Score =  115 bits (289), Expect = 6e-26
 Identities = 73/184 (39%), Positives = 98/184 (53%), Gaps = 21/184 (11%)

Query: 3   SFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLT 62
           S+ V L GP PWGFRLQGGKDFN+PL+ISR+TPG KAAQ+ ++ GD V++IDG N  ++T
Sbjct: 2   SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61

Query: 63  HIEAQNKIRACGERLSLGLSRAQ---PVQSKPQKVQTPDKQPLRPLVPDASKQRLMENTE 119
           H+EAQNKI++    LSL L +++   P+ +    VQTP      P++P      L  N  
Sbjct: 62  HLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTP-----LPVIPHQKDPALDTNGS 116

Query: 120 DWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAPASSTPQEPWPGP 179
              P P      S        GT     P    L+ +   P    P+  SS  +   PGP
Sbjct: 117 LVAPSPSPEARAS-------PGT-----PGTPELRPTFS-PAFSRPSAFSSLAEASDPGP 163

Query: 180 TAPS 183
              S
Sbjct: 164 PRAS 167



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 29/58 (50%), Positives = 39/58 (67%)

Query: 110 SKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAP 167
           S+ +  +  ++W  R    QSRSFRILA +TGTEFMQDPDEE L++S +   TE  +P
Sbjct: 252 SQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSRERFETERNSP 309


>gi|54112385 four and a half LIM domains 3 [Homo sapiens]
          Length = 280

 Score =  115 bits (289), Expect = 6e-26
 Identities = 56/173 (32%), Positives = 83/173 (47%), Gaps = 4/173 (2%)

Query: 248 CHQCHKVIR--GRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           C  C + +    R L   G  +H   F+CS C + L    F  +KGA +C PCY+ ++AP
Sbjct: 101 CSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFAP 160

Query: 306 SCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTK 365
            CA+C K +T   +      WH  C  C  C+TP+  + F   +  PYC   + ++F  K
Sbjct: 161 RCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGELFAPK 220

Query: 366 CHGCDFKID--AGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLCK 416
           C  C   I    G +++      WH  CF CA C  +L G+ F    D+ LC+
Sbjct: 221 CSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQ 273



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 49/172 (28%), Positives = 77/172 (44%), Gaps = 6/172 (3%)

Query: 248 CHQCHKVIR--GRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           C +C ++I    R L      +H   F C +C + L +  F  +   + C  CY   ++ 
Sbjct: 40  CAECQQLIGHDSRELFYEDRHFHEGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSS 99

Query: 306 SCAKCKKKIT--GEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFG 363
            C+ C + +      +     TWH HCF C+ C+ P+ +R+F  ++G  YC   YE  F 
Sbjct: 100 QCSACGETVMPGSRKLEYGGQTWHEHCFLCSGCEQPLGSRSFVPDKGAHYCVPCYENKFA 159

Query: 364 TKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLC 415
            +C  C   +  G   +      WH  C VC  CQ  L G+ F S+ + P C
Sbjct: 160 PRCARCSKTLTQGG--VTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYC 209



 Score = 87.4 bits (215), Expect = 2e-17
 Identities = 42/148 (28%), Positives = 69/148 (46%), Gaps = 2/148 (1%)

Query: 270 EEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVH 329
           E F C++C + L    + +     +C PCYD  +A +CA+C++ I  +         H H
Sbjct: 3   ESFDCAKCNESLYGRKYIQTDSGPYCVPCYDNTFANTCAECQQLIGHDSRELFYEDRHFH 62

Query: 330 --CFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSW 387
             CF C  C+  + +  F  ++    C   Y   F ++C  C   +  G R LE  G +W
Sbjct: 63  EGCFRCCRCQRSLADEPFTCQDSELLCNDCYCSAFSSQCSACGETVMPGSRKLEYGGQTW 122

Query: 388 HDTCFVCAICQINLEGKTFYSKKDRPLC 415
           H+ CF+C+ C+  L  ++F   K    C
Sbjct: 123 HEHCFLCSGCEQPLGSRSFVPDKGAHYC 150



 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 31/118 (26%), Positives = 49/118 (41%), Gaps = 4/118 (3%)

Query: 242 NGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDV 301
           N   P C +C K +    +      +H E  VC+ C   L    F       +C  C+  
Sbjct: 156 NKFAPRCARCSKTLTQGGVTYRDQPWHRECLVCTGCQTPLAGQQFTSRDEDPYCVACFGE 215

Query: 302 RYAPSCAKCKKKIT----GEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCE 355
            +AP C+ CK+ I     G+ +      WH +CF+CA C T +  + F  +     C+
Sbjct: 216 LFAPKCSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQ 273



 Score = 28.9 bits (63), Expect = 9.2
 Identities = 15/57 (26%), Positives = 23/57 (40%), Gaps = 4/57 (7%)

Query: 246 PVCHQCHKVI----RGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPC 298
           P C  C + I     G+Y+      +H   F C++C   L   GF  +   + C  C
Sbjct: 219 PKCSSCKRPIVGLGGGKYVSFEDRHWHHNCFSCARCSTSLVGQGFVPDGDQVLCQGC 275


>gi|122056619 LIM domain binding 3 isoform 4 [Homo sapiens]
          Length = 283

 Score =  114 bits (284), Expect = 2e-25
 Identities = 54/98 (55%), Positives = 73/98 (74%), Gaps = 3/98 (3%)

Query: 3  SFKVVLEGPAPWGFRLQGGKDFNVPLSISRLTPGGKAAQAGVAVGDWVLSIDGENAGSLT 62
          S+ V L GP PWGFRLQGGKDFN+PL+ISR+TPG KAAQ+ ++ GD V++IDG N  ++T
Sbjct: 2  SYSVTLTGPGPWGFRLQGGKDFNMPLTISRITPGSKAAQSQLSQGDLVVAIDGVNTDTMT 61

Query: 63 HIEAQNKIRACGERLSLGLSRAQ---PVQSKPQKVQTP 97
          H+EAQNKI++    LSL L +++   P+ +    VQTP
Sbjct: 62 HLEAQNKIKSASYNLSLTLQKSKRPIPISTTAPPVQTP 99



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 29/58 (50%), Positives = 39/58 (67%)

Query: 110 SKQRLMENTEDWRPRPGTGQSRSFRILAHLTGTEFMQDPDEEHLKKSSQVPRTEAPAP 167
           S+ +  +  ++W  R    QSRSFRILA +TGTEFMQDPDEE L++S +   TE  +P
Sbjct: 205 SQNKPEDEADEWARRSSNLQSRSFRILAQMTGTEFMQDPDEEALRRSRERFETERNSP 262


>gi|7662330 actin binding LIM protein family, member 3 [Homo
           sapiens]
          Length = 683

 Score =  111 bits (278), Expect = 1e-24
 Identities = 71/187 (37%), Positives = 86/187 (45%), Gaps = 18/187 (9%)

Query: 248 CHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGA-IFCPPCYD------ 300
           C  C   I G  + ALG  YHP+ FVCS C K    G      G    C  C        
Sbjct: 82  CDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECVCQTCSQSMASSK 141

Query: 301 ---VRYAPSCAKCKKKIT-GEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCER 356
              +R    CA CK++I  G+ + AL   WHV CF C  C   I    +  ++GVPYCE 
Sbjct: 142 PIKIRGPSHCAGCKEEIKHGQSLLALDKQWHVSCFKCQTCSV-ILTGEYISKDGVPYCES 200

Query: 357 DYEKMFGTKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAIC-QINLEGKTFY---SKKDR 412
           DY   FG KC  CD  I    R LEA G  +H TC  C  C Q+  EG+  Y   S+   
Sbjct: 201 DYHAQFGIKCETCDRYISG--RVLEAGGKHYHPTCARCVRCHQMFTEGEEMYLTGSEVWH 258

Query: 413 PLCKSHA 419
           P+CK  A
Sbjct: 259 PICKQAA 265



 Score = 94.4 bits (233), Expect = 2e-19
 Identities = 61/194 (31%), Positives = 85/194 (43%), Gaps = 19/194 (9%)

Query: 236 PGGGSNNGKTPVCHQCHKVIRGRYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFC 295
           P G SN      C++C    +G  +    + +H   F C  CG  L + GFF +     C
Sbjct: 14  PRGSSN---VIQCYRCGDTCKGEVVRVHNNHFHIRCFTCQVCGCGLAQSGFFFKNQEYIC 70

Query: 296 PPCYDVRYAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPI---RNRAFYMEEGVP 352
              Y   Y   C  C+  ITGE++ AL  T+H  CF C+ C+ P        F  +E V 
Sbjct: 71  TQDYQQLYGTRCDSCRDFITGEVISALGRTYHPKCFVCSLCRKPFPIGDKVTFSGKECV- 129

Query: 353 YCERDYEKMFGTK---------CHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEG 403
            C+   + M  +K         C GC  +I  G   L AL   WH +CF C  C + L G
Sbjct: 130 -CQTCSQSMASSKPIKIRGPSHCAGCKEEIKHGQSLL-ALDKQWHVSCFKCQTCSVILTG 187

Query: 404 KTFYSKKDRPLCKS 417
           + + SK   P C+S
Sbjct: 188 E-YISKDGVPYCES 200


>gi|228480213 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  109 bits (272), Expect = 5e-24
 Identities = 56/176 (31%), Positives = 78/176 (44%), Gaps = 5/176 (2%)

Query: 245 TPVCHQCHK-VIRGRYLVAL-GHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVR 302
           +P C  C K ++ G   V   G  +H + F CS C +V+  G FF +    +C  C++ +
Sbjct: 98  SPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETK 157

Query: 303 YAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMF 362
           +A  C KC K IT   +      WH  CF C  C   +  + F   E   YC   Y+   
Sbjct: 158 FAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFV 217

Query: 363 GTKCHGCDFKIDA---GDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLC 415
             KC GC   I     G   +   G SWHD CF C  C +NL  K F   +++  C
Sbjct: 218 AKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 273



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 45/148 (30%), Positives = 69/148 (46%), Gaps = 2/148 (1%)

Query: 270 EEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEI--MHALKMTWH 327
           E+F C  C   L+   + ++ G   C  C+D   A +C +C+K I  +   +H     WH
Sbjct: 3   EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 62

Query: 328 VHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSW 387
             CF CA C  P+ N  F  ++    C +   +    KC GC   I AGD+ +E  G  W
Sbjct: 63  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 122

Query: 388 HDTCFVCAICQINLEGKTFYSKKDRPLC 415
           H  CF C+ C+  +   +F+ K +   C
Sbjct: 123 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 150



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 51/172 (29%), Positives = 72/172 (41%), Gaps = 6/172 (3%)

Query: 248 CHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           C +C K I    + +      +H   F C++C   L    F  +   I C  C     +P
Sbjct: 40  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 99

Query: 306 SCAKCKKKI-TGEIMHALKMT-WHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFG 363
            C  C K I  G+     K T WH  CFTC+ CK  I   +F+ +    YC   +E  F 
Sbjct: 100 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 159

Query: 364 TKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLC 415
             C  C+  I +G   +      WH  CFVC  C   L G+ F + +D+  C
Sbjct: 160 KHCVKCNKAITSGG--ITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 209


>gi|228480207 four and a half LIM domains 1 isoform 2 [Homo sapiens]
          Length = 280

 Score =  109 bits (272), Expect = 5e-24
 Identities = 56/176 (31%), Positives = 78/176 (44%), Gaps = 5/176 (2%)

Query: 245 TPVCHQCHK-VIRGRYLVAL-GHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVR 302
           +P C  C K ++ G   V   G  +H + F CS C +V+  G FF +    +C  C++ +
Sbjct: 98  SPKCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETK 157

Query: 303 YAPSCAKCKKKITGEIMHALKMTWHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMF 362
           +A  C KC K IT   +      WH  CF C  C   +  + F   E   YC   Y+   
Sbjct: 158 FAKHCVKCNKAITSGGITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYCVDCYKNFV 217

Query: 363 GTKCHGCDFKIDA---GDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLC 415
             KC GC   I     G   +   G SWHD CF C  C +NL  K F   +++  C
Sbjct: 218 AKKCAGCKNPITGFGKGSSVVAYEGQSWHDYCFHCKKCSVNLANKRFVFHQEQVYC 273



 Score = 87.0 bits (214), Expect = 3e-17
 Identities = 45/148 (30%), Positives = 69/148 (46%), Gaps = 2/148 (1%)

Query: 270 EEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAPSCAKCKKKITGEI--MHALKMTWH 327
           E+F C  C   L+   + ++ G   C  C+D   A +C +C+K I  +   +H     WH
Sbjct: 3   EKFDCHYCRDPLQGKKYVQKDGHHCCLKCFDKFCANTCVECRKPIGADSKEVHYKNRFWH 62

Query: 328 VHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFGTKCHGCDFKIDAGDRFLEALGFSW 387
             CF CA C  P+ N  F  ++    C +   +    KC GC   I AGD+ +E  G  W
Sbjct: 63  DTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSPKCKGCFKAIVAGDQNVEYKGTVW 122

Query: 388 HDTCFVCAICQINLEGKTFYSKKDRPLC 415
           H  CF C+ C+  +   +F+ K +   C
Sbjct: 123 HKDCFTCSNCKQVIGTGSFFPKGEDFYC 150



 Score = 76.3 bits (186), Expect = 5e-14
 Identities = 51/172 (29%), Positives = 72/172 (41%), Gaps = 6/172 (3%)

Query: 248 CHQCHKVIRG--RYLVALGHAYHPEEFVCSQCGKVLEEGGFFEEKGAIFCPPCYDVRYAP 305
           C +C K I    + +      +H   F C++C   L    F  +   I C  C     +P
Sbjct: 40  CVECRKPIGADSKEVHYKNRFWHDTCFRCAKCLHPLANETFVAKDNKILCNKCTTREDSP 99

Query: 306 SCAKCKKKI-TGEIMHALKMT-WHVHCFTCAACKTPIRNRAFYMEEGVPYCERDYEKMFG 363
            C  C K I  G+     K T WH  CFTC+ CK  I   +F+ +    YC   +E  F 
Sbjct: 100 KCKGCFKAIVAGDQNVEYKGTVWHKDCFTCSNCKQVIGTGSFFPKGEDFYCVTCHETKFA 159

Query: 364 TKCHGCDFKIDAGDRFLEALGFSWHDTCFVCAICQINLEGKTFYSKKDRPLC 415
             C  C+  I +G   +      WH  CFVC  C   L G+ F + +D+  C
Sbjct: 160 KHCVKCNKAITSGG--ITYQDQPWHADCFVCVTCSKKLAGQRFTAVEDQYYC 209


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.439 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,384,295
Number of Sequences: 37866
Number of extensions: 1161099
Number of successful extensions: 10617
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 267
Number of HSP's successfully gapped in prelim test: 555
Number of HSP's that attempted gapping in prelim test: 7660
Number of HSP's gapped (non-prelim): 2585
length of query: 423
length of database: 18,247,518
effective HSP length: 105
effective length of query: 318
effective length of database: 14,271,588
effective search space: 4538364984
effective search space used: 4538364984
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.