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Search of human proteins with 42741659
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
(1280 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo sa... 2482 0.0
gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A... 1902 0.0
gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B... 1895 0.0
gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C... 1810 0.0
gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member... 1287 0.0
gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo ... 937 0.0
gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo... 350 5e-96
gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo ... 325 2e-88
gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member ... 317 4e-86
gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member... 317 4e-86
gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member ... 296 6e-80
gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Ho... 263 8e-70
gi|73747915 transporter 2, ATP-binding cassette, sub-family B is... 245 2e-64
gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo sa... 240 6e-63
gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member... 240 7e-63
gi|89111135 ATP-binding cassette protein C12 [Homo sapiens] 240 7e-63
gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform... 239 9e-63
gi|157502201 ATP-binding cassette, sub-family C, member 4 isofor... 236 1e-61
gi|134142337 ATP-binding cassette, sub-family C, member 1 isofor... 234 3e-61
gi|110832837 ATP-binding cassette, sub-family C, member 9 isofor... 231 4e-60
gi|190343023 ATP-binding cassette, sub-family C, member 6 isofor... 228 3e-59
gi|239756495 PREDICTED: hypothetical protein [Homo sapiens] 228 3e-59
gi|73747917 transporter 2, ATP-binding cassette, sub-family B is... 226 1e-58
gi|110832835 ATP-binding cassette, sub-family C, member 9 isofor... 224 3e-58
gi|110832839 ATP-binding cassette, sub-family C, member 9 isofor... 224 5e-58
gi|21729873 ATP-binding cassette, sub-family C, member 11 isofor... 219 2e-56
gi|15149474 ATP-binding cassette, sub-family C, member 11 isofor... 219 2e-56
gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo ... 218 4e-56
gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform ... 213 7e-55
gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo s... 208 3e-53
>gi|42741659 ATP-binding cassette, subfamily B, member 1 [Homo
sapiens]
Length = 1280
Score = 2482 bits (6433), Expect = 0.0
Identities = 1280/1280 (100%), Positives = 1280/1280 (100%)
Query: 1 MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII 60
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII
Sbjct: 1 MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAII 60
Query: 61 HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG 120
HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG
Sbjct: 61 HGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSG 120
Query: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS
Sbjct: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
Query: 181 KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT 240
KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT
Sbjct: 181 KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT 240
Query: 241 DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG 300
DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG
Sbjct: 241 DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG 300
Query: 301 AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG 360
AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG
Sbjct: 301 AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG 360
Query: 361 AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG 420
AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG
Sbjct: 361 AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG 420
Query: 421 QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF 480
QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF
Sbjct: 421 QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF 480
Query: 481 ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA 540
ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA
Sbjct: 481 ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA 540
Query: 541 IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG 600
IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG
Sbjct: 541 IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG 600
Query: 601 FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS 660
FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS
Sbjct: 601 FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRS 660
Query: 661 SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII 720
SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII
Sbjct: 661 SLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAII 720
Query: 721 NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA 780
NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA
Sbjct: 721 NGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKA 780
Query: 781 GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI 840
GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI
Sbjct: 781 GEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNI 840
Query: 841 ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA 900
ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA
Sbjct: 841 ANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEA 900
Query: 901 IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG 960
IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG
Sbjct: 901 IENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG 960
Query: 961 AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS 1020
AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS
Sbjct: 961 AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS 1020
Query: 1021 YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV 1080
YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV
Sbjct: 1021 YSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVV 1080
Query: 1081 QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV 1140
QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV
Sbjct: 1081 QLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVV 1140
Query: 1141 SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD 1200
SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD
Sbjct: 1141 SQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLD 1200
Query: 1201 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL 1260
EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL
Sbjct: 1201 EATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQL 1260
Query: 1261 LAQKGIYFSMVSVQAGTKRQ 1280
LAQKGIYFSMVSVQAGTKRQ
Sbjct: 1261 LAQKGIYFSMVSVQAGTKRQ 1280
>gi|4505771 ATP-binding cassette, subfamily B, member 4 isoform A
[Homo sapiens]
Length = 1279
Score = 1902 bits (4927), Expect = 0.0
Identities = 977/1289 (75%), Positives = 1117/1289 (86%), Gaps = 23/1289 (1%)
Query: 1 MDLEGDRNGGAKK----KNFFKLNNKSEKDKKEKKPT--VSVFSMFRYSNWLDKLYMVVG 54
MDLE +NG A + + F+L S++ +K+ K + V ++FRYS+W DKL+M +G
Sbjct: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
Query: 55 TLAAIIHGAGLPLMMLVFGEMTDIFAN-AGNLE---DLMSNITNRSDINDTGFFMNLEED 110
T+ AI HG+GLPLMM+VFGEMTD F + AGN + ++ N I LEE+
Sbjct: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKI--------LEEE 112
Query: 111 MTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGE 170
MTRYAYYYSG+GAGVLVAAYIQVSFW LAAGRQI KIR++FFHAI+RQEIGWFD++D E
Sbjct: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
Query: 171 LNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAA 230
LNTRLTDD+SKI+EGIGDK+GMFFQ++ATFF GFIVGF RGWKLTLVI+AISP+LGLSAA
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
Query: 231 VWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIK 290
VWAKILS+F+DKEL AYAKAGAVAEE L AIRTVIAFGGQ KELERY K+LE AK IGIK
Sbjct: 233 VWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIK 292
Query: 291 KAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350
KAI+ANIS+G AFLLIYASYALAFWYG+TLV+S EY+IG +TVFFS+LIGAFSVGQA+P
Sbjct: 293 KAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAP 352
Query: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKIL 410
I+AFANARGAAY IF IIDN P IDS+S+ GHKPD+IKGNLEF +VHFSYPSR VKIL
Sbjct: 353 CIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKIL 412
Query: 411 KGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREII 470
KGLNLKVQSGQTVALVG+SGCGKSTTVQL+QRLYDP EG +++DGQDIR NV +LREII
Sbjct: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
Query: 471 GVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQ 530
GVVSQEPVLF+TTIAENI YGR NVTMDEI+KAVKEANAY+FIMKLP KFDTLVGERGAQ
Sbjct: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQ 532
Query: 531 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLS 590
LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA VQ ALDKAR+GRTTIVIAHRLS
Sbjct: 533 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLS 592
Query: 591 TVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDA 650
TVRNADVIAGF+DGVIVE+G+H ELMK++G+YFKLV MQT+G++++ E E E A
Sbjct: 593 TVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEF--ELNDEKAA 650
Query: 651 LEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK-EALDESIPPVSFWRIMKLNLTEWP 709
M+ N +S L R ST+++++ SQ + L + + L+ ++PPVSF +++KLN TEWP
Sbjct: 651 TRMAPNGWKSRLFR-HSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWP 709
Query: 710 YFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFIT 769
YFVVG CAI NGGLQPAF++IFS+II +F DD K+Q N+FSL+FL LGIISF T
Sbjct: 710 YFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDD-AVKQQKCNIFSLIFLFLGIISFFT 768
Query: 770 FFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAI 829
FFLQGFTFGKAGEILT+RLR M F++MLRQD+SWFDD KN+TGAL+TRLA DAAQV+GA
Sbjct: 769 FFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGAT 828
Query: 830 GSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE 889
G+RLA+I QNIANLGTGIIISFIYGWQLTLLLLA+VPIIA++G+VEMK+L+G A +DKKE
Sbjct: 829 GTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKE 888
Query: 890 LEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMM 949
LE +GKIATEAIEN RTVVSLTQE+KFE MY + L PYRNS++KAHI+GITFS +QA M
Sbjct: 889 LEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFM 948
Query: 950 YFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHII 1009
YFSYAGCFRFGAYL+ + M F DV+LVFSA+VFGA+A+G SSFAPDYAKAK+SAAH+
Sbjct: 949 YFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 1008
Query: 1010 MIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALV 1069
M+ E+ PLIDSYS EGL P+ EGN+TF EVVFNYPTR ++PVLQGLSLEVKKGQTLALV
Sbjct: 1009 MLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1068
Query: 1070 GSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAE 1129
GSSGCGKSTVVQLLERFYDPLAG VLLDG+E K+LNVQWLRA LGIVSQEPILFDCSIAE
Sbjct: 1069 GSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAE 1128
Query: 1130 NIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARA 1189
NIAYGDNSRVVSQ+EIV AAK ANIH FIE+LP+KY T+VGDKGTQLSGGQKQRIAIARA
Sbjct: 1129 NIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARA 1188
Query: 1190 LVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1249
L+RQP ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG
Sbjct: 1189 LIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1248
Query: 1250 RVKEHGTHQQLLAQKGIYFSMVSVQAGTK 1278
RVKEHGTHQQLLAQKGIYFSMVSVQAGT+
Sbjct: 1249 RVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1277
>gi|9961250 ATP-binding cassette, subfamily B, member 4 isoform B
[Homo sapiens]
Length = 1286
Score = 1895 bits (4909), Expect = 0.0
Identities = 977/1296 (75%), Positives = 1117/1296 (86%), Gaps = 30/1296 (2%)
Query: 1 MDLEGDRNGGAKK----KNFFKLNNKSEKDKKEKKPT--VSVFSMFRYSNWLDKLYMVVG 54
MDLE +NG A + + F+L S++ +K+ K + V ++FRYS+W DKL+M +G
Sbjct: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
Query: 55 TLAAIIHGAGLPLMMLVFGEMTDIFAN-AGNLE---DLMSNITNRSDINDTGFFMNLEED 110
T+ AI HG+GLPLMM+VFGEMTD F + AGN + ++ N I LEE+
Sbjct: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKI--------LEEE 112
Query: 111 MTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGE 170
MTRYAYYYSG+GAGVLVAAYIQVSFW LAAGRQI KIR++FFHAI+RQEIGWFD++D E
Sbjct: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
Query: 171 LNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAA 230
LNTRLTDD+SKI+EGIGDK+GMFFQ++ATFF GFIVGF RGWKLTLVI+AISP+LGLSAA
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
Query: 231 VWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIK 290
VWAKILS+F+DKEL AYAKAGAVAEE L AIRTVIAFGGQ KELERY K+LE AK IGIK
Sbjct: 233 VWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIK 292
Query: 291 KAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350
KAI+ANIS+G AFLLIYASYALAFWYG+TLV+S EY+IG +TVFFS+LIGAFSVGQA+P
Sbjct: 293 KAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAP 352
Query: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKIL 410
I+AFANARGAAY IF IIDN P IDS+S+ GHKPD+IKGNLEF +VHFSYPSR VKIL
Sbjct: 353 CIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKIL 412
Query: 411 KGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREII 470
KGLNLKVQSGQTVALVG+SGCGKSTTVQL+QRLYDP EG +++DGQDIR NV +LREII
Sbjct: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
Query: 471 GVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQ 530
GVVSQEPVLF+TTIAENI YGR NVTMDEI+KAVKEANAY+FIMKLP KFDTLVGERGAQ
Sbjct: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQ 532
Query: 531 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLS 590
LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA VQ ALDKAR+GRTTIVIAHRLS
Sbjct: 533 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLS 592
Query: 591 TVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDA 650
TVRNADVIAGF+DGVIVE+G+H ELMK++G+YFKLV MQT+G++++ E E E A
Sbjct: 593 TVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEF--ELNDEKAA 650
Query: 651 LEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK-EALDESIPPVSFWRIMKLNLTEWP 709
M+ N +S L R ST+++++ SQ + L + + L+ ++PPVSF +++KLN TEWP
Sbjct: 651 TRMAPNGWKSRLFR-HSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWP 709
Query: 710 YFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFIT 769
YFVVG CAI NGGLQPAF++IFS+II +F DD K+Q N+FSL+FL LGIISF T
Sbjct: 710 YFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDD-AVKQQKCNIFSLIFLFLGIISFFT 768
Query: 770 FFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAI 829
FFLQGFTFGKAGEILT+RLR M F++MLRQD+SWFDD KN+TGAL+TRLA DAAQV+GA
Sbjct: 769 FFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGAT 828
Query: 830 GSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE 889
G+RLA+I QNIANLGTGIIISFIYGWQLTLLLLA+VPIIA++G+VEMK+L+G A +DKKE
Sbjct: 829 GTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKE 888
Query: 890 LEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMM 949
LE +GKIATEAIEN RTVVSLTQE+KFE MY + L PYRNS++KAHI+GITFS +QA M
Sbjct: 889 LEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFM 948
Query: 950 YFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHII 1009
YFSYAGCFRFGAYL+ + M F DV+LVFSA+VFGA+A+G SSFAPDYAKAK+SAAH+
Sbjct: 949 YFSYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 1008
Query: 1010 MIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALV 1069
M+ E+ PLIDSYS EGL P+ EGN+TF EVVFNYPTR ++PVLQGLSLEVKKGQTLALV
Sbjct: 1009 MLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1068
Query: 1070 GSSGCGKSTVVQLLERFYDPLAGKV-------LLDGKEIKRLNVQWLRAHLGIVSQEPIL 1122
GSSGCGKSTVVQLLERFYDPLAG V LLDG+E K+LNVQWLRA LGIVSQEPIL
Sbjct: 1069 GSSGCGKSTVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPIL 1128
Query: 1123 FDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQ 1182
FDCSIAENIAYGDNSRVVSQ+EIV AAK ANIH FIE+LP+KY T+VGDKGTQLSGGQKQ
Sbjct: 1129 FDCSIAENIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQ 1188
Query: 1183 RIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADL 1242
RIAIARAL+RQP ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADL
Sbjct: 1189 RIAIARALIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADL 1248
Query: 1243 IVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTK 1278
IVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGT+
Sbjct: 1249 IVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1284
>gi|9961252 ATP-binding cassette, subfamily B, member 4 isoform C
[Homo sapiens]
Length = 1232
Score = 1810 bits (4687), Expect = 0.0
Identities = 944/1289 (73%), Positives = 1077/1289 (83%), Gaps = 70/1289 (5%)
Query: 1 MDLEGDRNGGAKK----KNFFKLNNKSEKDKKEKKPT--VSVFSMFRYSNWLDKLYMVVG 54
MDLE +NG A + + F+L S++ +K+ K + V ++FRYS+W DKL+M +G
Sbjct: 1 MDLEAAKNGTAWRPTSAEGDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLG 60
Query: 55 TLAAIIHGAGLPLMMLVFGEMTDIFAN-AGNLE---DLMSNITNRSDINDTGFFMNLEED 110
T+ AI HG+GLPLMM+VFGEMTD F + AGN + ++ N I LEE+
Sbjct: 61 TIMAIAHGSGLPLMMIVFGEMTDKFVDTAGNFSFPVNFSLSLLNPGKI--------LEEE 112
Query: 111 MTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGE 170
MTRYAYYYSG+GAGVLVAAYIQVSFW LAAGRQI KIR++FFHAI+RQEIGWFD++D E
Sbjct: 113 MTRYAYYYSGLGAGVLVAAYIQVSFWTLAAGRQIRKIRQKFFHAILRQEIGWFDINDTTE 172
Query: 171 LNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAA 230
LNTRLTDD+SKI+EGIGDK+GMFFQ++ATFF GFIVGF RGWKLTLVI+AISP+LGLSAA
Sbjct: 173 LNTRLTDDISKISEGIGDKVGMFFQAVATFFAGFIVGFIRGWKLTLVIMAISPILGLSAA 232
Query: 231 VWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIK 290
VWAKILS+F+DKEL AYAKAGAVAEE L AIRTVIAFGGQ KELERY K+LE AK IGIK
Sbjct: 233 VWAKILSAFSDKELAAYAKAGAVAEEALGAIRTVIAFGGQNKELERYQKHLENAKEIGIK 292
Query: 291 KAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350
KAI+ANIS+G AFLLIYASYALAFWYG+TLV+S EY+IG +TVFFS+LIGAFSVGQA+P
Sbjct: 293 KAISANISMGIAFLLIYASYALAFWYGSTLVISKEYTIGNAMTVFFSILIGAFSVGQAAP 352
Query: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKIL 410
I+AFANARGAAY IF IIDN P IDS+S+ GHKPD+IKGNLEF +VHFSYPSR VKIL
Sbjct: 353 CIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDSIKGNLEFNDVHFSYPSRANVKIL 412
Query: 411 KGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREII 470
KGLNLKVQSGQTVALVG+SGCGKSTTVQL+QRLYDP EG +++DGQDIR NV +LREII
Sbjct: 413 KGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTINIDGQDIRNFNVNYLREII 472
Query: 471 GVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQ 530
GVVSQEPVLF+TTIAENI YGR NVTMDEI+KAVKEANAY+FIMKLP KFDTLVGERGAQ
Sbjct: 473 GVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLPQKFDTLVGERGAQ 532
Query: 531 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLS 590
LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA VQ ALDKAR+GRTTIVIAHRLS
Sbjct: 533 LSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTTIVIAHRLS 592
Query: 591 TVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDA 650
TVRNADVIAGF+DGVIVE+G+H ELMK++G+YFKLV MQT+G++++ E E E A
Sbjct: 593 TVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNMQTSGSQIQSEEF--ELNDEKAA 650
Query: 651 LEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK-EALDESIPPVSFWRIMKLNLTEWP 709
M+ N +S L R ST+++++ SQ + L + + L+ ++PPVSF +++KLN TEWP
Sbjct: 651 TRMAPNGWKSRLFR-HSTQKNLKNSQMCQKSLDVETDGLEANVPPVSFLKVLKLNKTEWP 709
Query: 710 YFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFIT 769
YFVVG CAI NGGLQPAF++IFS+II +F DD K+Q N+FSL+FL LGIISF T
Sbjct: 710 YFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDD-AVKQQKCNIFSLIFLFLGIISFFT 768
Query: 770 FFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAI 829
FFLQGFTFGKAGEILT+RLR M F++MLRQD+SWFDD KN+TGAL+TRLA DAAQV+GA
Sbjct: 769 FFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATDAAQVQGAT 828
Query: 830 GSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKE 889
G+RLA+I QNIANLGTGIIISFIYGWQLTLLLLA+VPIIA++G+VEMK+L+G A +DKKE
Sbjct: 829 GTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRDKKE 888
Query: 890 LEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMM 949
LE +GKIATEAIEN RTVVSLTQE+KFE MY + L PYR
Sbjct: 889 LEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYR-------------------- 928
Query: 950 YFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHII 1009
VFSA+VFGA+A+G SSFAPDYAKAK+SAAH+
Sbjct: 929 ---------------------------VFSAIVFGAVALGHASSFAPDYAKAKLSAAHLF 961
Query: 1010 MIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALV 1069
M+ E+ PLIDSYS EGL P+ EGN+TF EVVFNYPTR ++PVLQGLSLEVKKGQTLALV
Sbjct: 962 MLFERQPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1021
Query: 1070 GSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAE 1129
GSSGCGKSTVVQLLERFYDPLAG VLLDG+E K+LNVQWLRA LGIVSQEPILFDCSIAE
Sbjct: 1022 GSSGCGKSTVVQLLERFYDPLAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAE 1081
Query: 1130 NIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARA 1189
NIAYGDNSRVVSQ+EIV AAK ANIH FIE+LP+KY T+VGDKGTQLSGGQKQRIAIARA
Sbjct: 1082 NIAYGDNSRVVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARA 1141
Query: 1190 LVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1249
L+RQP ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG
Sbjct: 1142 LIRQPQILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNG 1201
Query: 1250 RVKEHGTHQQLLAQKGIYFSMVSVQAGTK 1278
RVKEHGTHQQLLAQKGIYFSMVSVQAGT+
Sbjct: 1202 RVKEHGTHQQLLAQKGIYFSMVSVQAGTQ 1230
>gi|21536378 ATP-binding cassette, sub-family B (MDR/TAP), member 11
[Homo sapiens]
Length = 1321
Score = 1287 bits (3330), Expect = 0.0
Identities = 663/1306 (50%), Positives = 907/1306 (69%), Gaps = 42/1306 (3%)
Query: 5 GDRNGGAKKKNFFKLNNKS--EKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHG 62
G+ N G + + + KS + +KK V F +FR+S+ D M VG+L A +HG
Sbjct: 14 GEENDGFESDKSYNNDKKSRLQDEKKGDGVRVGFFQLFRFSSSTDIWLMFVGSLCAFLHG 73
Query: 63 AGLPLMMLVFGEMTDIFANAG-NLEDLMSNITNRSDINDTGFF----------------- 104
P ++L+FG MTD+F + L++L I ++ +N+T +
Sbjct: 74 IAQPGVLLIFGTMTDVFIDYDVELQELQ--IPGKACVNNTIVWTNSSLNQNMTNGTRCGL 131
Query: 105 MNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFD 164
+N+E +M ++A YY+GI VL+ YIQ+ FW +AA RQI K+RK +F IMR EIGWFD
Sbjct: 132 LNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFD 191
Query: 165 VHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPV 224
+ VGELNTR +DD++KIN+ I D++ +F Q M + GF++GF RGWKLTLVI+++SP+
Sbjct: 192 CNSVGELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPL 251
Query: 225 LGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEA 284
+G+ AA +S FTD EL AYAKAG VA+EV++++RTV AFGG+K+E+ERY KNL A
Sbjct: 252 IGIGAATIGLSVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFA 311
Query: 285 KRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS-GEYSIGQVLTVFFSVLIGAF 343
+R GI+K I G + LI+ YALAFWYG+TLVL GEY+ G ++ +F SV++GA
Sbjct: 312 QRWGIRKGIVMGFFTGFVWCLIFLCYALAFWYGSTLVLDEGEYTPGTLVQIFLSVIVGAL 371
Query: 344 SVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPS 403
++G ASP +EAFA R AA IF+ ID KP ID S+ G+K D IKG +EF NV F YPS
Sbjct: 372 NLGNASPCLEAFATGRAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPS 431
Query: 404 RKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINV 463
R EVKIL LN+ ++ G+ ALVG SG GKST +QL+QR YDP EGMV+VDG DIR++N+
Sbjct: 432 RPEVKILNDLNMVIKPGEMTALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNI 491
Query: 464 RFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTL 523
++LR+ IG+V QEPVLF+TTIAENIRYGRE+ TM++I +A KEANAY+FIM LP +FDTL
Sbjct: 492 QWLRDQIGIVEQEPVLFSTTIAENIRYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTL 551
Query: 524 VGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTI 583
VGE G Q+SGGQKQR+AIARAL+RNPKILLLD ATSALD ESEA+VQ L K + G T I
Sbjct: 552 VGEGGGQMSGGQKQRVAIARALIRNPKILLLDMATSALDNESEAMVQEVLSKIQHGHTII 611
Query: 584 VIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNE-VELENAAD 642
+AHRLSTVR AD I GF+ G VE+G H+EL++ KG+YF LVT+Q+ GN+ + E+ D
Sbjct: 612 SVAHRLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKD 671
Query: 643 ESKSEIDALEMSSNDSRSSL---IRKRSTRR-------------SVRGSQAQDRKLSTKE 686
++ ++ A S + SL IR+RS + + + +DRK
Sbjct: 672 ATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRK-DKDI 730
Query: 687 ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPE 746
+ E + P RI+K + EWPY +VG A +NG + P +A +FS+I+G F+ I D E
Sbjct: 731 PVQEEVEPAPVRRILKFSAPEWPYMLVGSVGAAVNGTVTPLYAFLFSQILGTFS-IPDKE 789
Query: 747 TKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDD 806
+R N LLF+A+G +S T FLQG+ F K+GE+LTKRLR FR+ML QD++WFDD
Sbjct: 790 EQRSQINGVCLLFVAMGCVSLFTQFLQGYAFAKSGELLTKRLRKFGFRAMLGQDIAWFDD 849
Query: 807 PKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVP 866
+N+ GALTTRLA DA+QV+GA GS++ +I + N+ +II+F + W+L+L++L P
Sbjct: 850 LRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTNVTVAMIIAFSFSWKLSLVILCFFP 909
Query: 867 IIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQV 926
+A++G + +ML+G A +DK+ LE G+I EA+ N RTV + +E++F L+
Sbjct: 910 FLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTVAGIGKERRFIEALETELEK 969
Query: 927 PYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAM 986
P++ +++KA+I+G F+F Q +M+ + + +R+G YL++++ + F V V SAVV A
Sbjct: 970 PFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFSYVFRVISAVVLSAT 1029
Query: 987 AVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPT 1046
A+G+ S+ P YAKAKISAA ++++ P I Y+T G + +G + F + F YP+
Sbjct: 1030 ALGRAFSYTPSYAKAKISAARFFQLLDRQPPISVYNTAGEKWDNFQGKIDFVDCKFTYPS 1089
Query: 1047 RPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNV 1106
RPD VL GLS+ + GQTLA VGSSGCGKST +QLLERFYDP GKV++DG + K++NV
Sbjct: 1090 RPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMIDGHDSKKVNV 1149
Query: 1107 QWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYS 1166
Q+LR+++GIVSQEP+LF CSI +NI YGDN++ + E ++ AAK+A +H F+ SLP KY
Sbjct: 1150 QFLRSNIGIVSQEPVLFACSIMDNIKYGDNTKEIPMERVIAAAKQAQLHDFVMSLPEKYE 1209
Query: 1167 TKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRT 1226
T VG +G+QLS G+KQRIAIARA+VR P ILLLDEATSALDTESEK VQ ALDKAREGRT
Sbjct: 1210 TNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRT 1269
Query: 1227 CIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVS 1272
CIVIAHRLSTIQNAD+I V G V E GTH++L+AQKG Y+ +V+
Sbjct: 1270 CIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKLVT 1315
Score = 392 bits (1007), Expect = e-108
Identities = 224/619 (36%), Positives = 350/619 (56%), Gaps = 43/619 (6%)
Query: 695 VSFWRIMKLNLTE--WPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQ-- 750
V F+++ + + + W FV G CA ++G QP +IF + VF D + Q
Sbjct: 45 VGFFQLFRFSSSTDIWLMFV-GSLCAFLHGIAQPGVLLIFGTMTDVFIDYDVELQELQIP 103
Query: 751 ------------NSNL---------------------FSLLFLALGIISFITFFLQGFTF 777
NS+L F+ + + + IT ++Q +
Sbjct: 104 GKACVNNTIVWTNSSLNQNMTNGTRCGLLNIESEMIKFASYYAGIAVAVLITGYIQICFW 163
Query: 778 GKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVIT 837
A +++R FR ++R ++ WFD N+ G L TR ++D ++ AI ++A+
Sbjct: 164 VIAAARQIQKMRKFYFRRIMRMEIGWFDC--NSVGELNTRFSDDINKINDAIADQMALFI 221
Query: 838 QNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA 897
Q + + G ++ F GW+LTL+++++ P+I I +S + K +G +A
Sbjct: 222 QRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGLSVSKFTDYELKAYAKAGVVA 281
Query: 898 TEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCF 957
E I + RTV + E++ Y ++L R +RK + G F +++ YA F
Sbjct: 282 DEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFTGFVWCLIFLCYALAF 341
Query: 958 RFGAYLVAHKLMSFEDVLL-VFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTP 1016
+G+ LV + L+ +F +V+ GA+ +G S +A + +A I I++ P
Sbjct: 342 WYGSTLVLDEGEYTPGTLVQIFLSVIVGALNLGNASPCLEAFATGRAAATSIFETIDRKP 401
Query: 1017 LIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGK 1076
+ID S +G + ++G + F V F+YP+RP++ +L L++ +K G+ ALVG SG GK
Sbjct: 402 IIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMTALVGPSGAGK 461
Query: 1077 STVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDN 1136
ST +QL++RFYDP G V +DG +I+ LN+QWLR +GIV QEP+LF +IAENI YG
Sbjct: 462 STALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENIRYGRE 521
Query: 1137 SRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHI 1196
+ E+IV+AAKEAN + FI LP ++ T VG+ G Q+SGGQKQR+AIARAL+R P I
Sbjct: 522 D--ATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKI 579
Query: 1197 LLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1256
LLLD ATSALD ESE +VQE L K + G T I +AHRLST++ AD I+ F++G E GT
Sbjct: 580 LLLDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGT 639
Query: 1257 HQQLLAQKGIYFSMVSVQA 1275
H++LL +KG+YF++V++Q+
Sbjct: 640 HEELLERKGVYFTLVTLQS 658
>gi|148612844 ATP-binding cassette, sub-family B, member 5 [Homo
sapiens]
Length = 812
Score = 937 bits (2423), Expect = 0.0
Identities = 465/823 (56%), Positives = 632/823 (76%), Gaps = 14/823 (1%)
Query: 453 VDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDF 512
VD DIR +NVR R+ IGVVSQEPVLF TTI+ NI+YGR++VT +E+E+A +EANAYDF
Sbjct: 2 VDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDDVTDEEMERAAREANAYDF 61
Query: 513 IMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVA 572
IM+ P+KF+TLVGE+GAQ+SGGQKQRIAIARALVRNPKIL+LDEATSALD+ES++ VQ A
Sbjct: 62 IMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAVQAA 121
Query: 573 LDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAG 632
L+KA KGRTTIV+AHRLST+R+AD+I DG++ EKG H ELM ++G+Y+ LV Q
Sbjct: 122 LEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ--- 178
Query: 633 NEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESI 692
+++ A ++ +S + E +N ++ S++ S D+ + ++ + S+
Sbjct: 179 ---DIKKADEQMESMTYSTERKTNSLPLHSVK------SIK-SDFIDKAEESTQSKEISL 228
Query: 693 PPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNS 752
P VS +I+KLN EWP+ V+G +++NG + P F+IIF+KII +F +D T + ++
Sbjct: 229 PEVSLLKILKLNKPEWPFVVLGTLASVLNGTVHPVFSIIFAKIITMFGN-NDKTTLKHDA 287
Query: 753 NLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTG 812
++S++F+ LG+I F+++F+QG +G+AGEILT RLR++ F++ML QD++WFD+ +N+TG
Sbjct: 288 EIYSMIFVILGVICFVSYFMQGLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTG 347
Query: 813 ALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAG 872
LTT LA D AQ++GA GSR+ V+TQN N+G +IISFIYGW++T L+L+I P++A+ G
Sbjct: 348 GLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTG 407
Query: 873 VVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSL 932
++E ++G A KDK+EL+ +GKIATEA+EN RT+VSLT+E+ FE MY + LQ +RN+
Sbjct: 408 MIETAAMTGFANKDKQELKHAGKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTS 467
Query: 933 RKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVS 992
+KA I G ++F+ A +YF+YA FRFGAYL+ M+ E + +VF+A+ +GAMA+G+
Sbjct: 468 KKAQIIGSCYAFSHAFIYFAYAAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETL 527
Query: 993 SFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPV 1052
AP+Y+KAK AAH+ ++EK P IDS S EG P+T EGN+ F EV F YP RPD+ +
Sbjct: 528 VLAPEYSKAKSGAAHLFALLEKKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFI 587
Query: 1053 LQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAH 1112
L+GLSL +++G+T+A VGSSGCGKST VQLL+R YDP+ G+VL DG + K LNVQWLR+
Sbjct: 588 LRGLSLSIERGKTVAFVGSSGCGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQ 647
Query: 1113 LGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDK 1172
+ IV QEP+LF+CSIAENIAYGDNSRVV +EI AA ANIH+FIE LP KY+T+VG K
Sbjct: 648 IAIVPQEPVLFNCSIAENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLK 707
Query: 1173 GTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAH 1232
G QLSGGQKQR+AIARAL+++P ILLLDEATSALD +SEKVVQ ALDKAR GRTC+V+ H
Sbjct: 708 GAQLSGGQKQRLAIARALLQKPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTH 767
Query: 1233 RLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275
RLS IQNADLIVV NG++KE GTHQ+LL + IYF +V+ Q+
Sbjct: 768 RLSAIQNADLIVVLHNGKIKEQGTHQELLRNRDIYFKLVNAQS 810
Score = 436 bits (1121), Expect = e-122
Identities = 246/622 (39%), Positives = 369/622 (59%), Gaps = 25/622 (4%)
Query: 13 KKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVF 72
K +F +S + K+ P VS+ + + N + ++V+GTLA++++G P+ ++F
Sbjct: 210 KSDFIDKAEESTQSKEISLPEVSLLKILKL-NKPEWPFVVLGTLASVLNGTVHPVFSIIF 268
Query: 73 GEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQ 132
++ +F N ND L+ D Y+ + +G V+ ++Q
Sbjct: 269 AKIITMFGN-----------------NDK---TTLKHDAEIYSMIFVILGVICFVSYFMQ 308
Query: 133 VSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHD--VGELNTRLTDDVSKINEGIGDKI 190
F+ A ++R F A++ Q+I WFD + G L T L D+++I G +I
Sbjct: 309 GLFYGRAGEILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRI 368
Query: 191 GMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKA 250
G+ Q+ I+ F GW++T +IL+I+PVL ++ + ++ F +K+ A
Sbjct: 369 GVLTQNATNMGLSVIISFIYGWEMTFLILSIAPVLAVTGMIETAAMTGFANKDKQELKHA 428
Query: 251 GAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASY 310
G +A E L IRT+++ +K + Y + L+ R KKA + IY +Y
Sbjct: 429 GKIATEALENIRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAY 488
Query: 311 ALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIID 370
A F +G L+ +G + + VF ++ GA ++G+ ++ A+ A +F +++
Sbjct: 489 AAGFRFGAYLIQAGRMTPEGMFIVFTAIAYGAMAIGETLVLAPEYSKAKSGAAHLFALLE 548
Query: 371 NKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSG 430
KP+IDS S+ G KPD +GNLEFR V F YP R +V IL+GL+L ++ G+TVA VG+SG
Sbjct: 549 KKPNIDSRSQEGKKPDTCEGNLEFREVSFFYPCRPDVFILRGLSLSIERGKTVAFVGSSG 608
Query: 431 CGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRY 490
CGKST+VQL+QRLYDP +G V DG D + +NV++LR I +V QEPVLF +IAENI Y
Sbjct: 609 CGKSTSVQLLQRLYDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFNCSIAENIAY 668
Query: 491 GREN--VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRN 548
G + V +DEI++A AN + FI LP K++T VG +GAQLSGGQKQR+AIARAL++
Sbjct: 669 GDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQK 728
Query: 549 PKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVE 608
PKILLLDEATSALD +SE VVQ ALDKAR GRT +V+ HRLS ++NAD+I +G I E
Sbjct: 729 PKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKE 788
Query: 609 KGNHDELMKEKGIYFKLVTMQT 630
+G H EL++ + IYFKLV Q+
Sbjct: 789 QGTHQELLRNRDIYFKLVNAQS 810
Score = 207 bits (527), Expect = 5e-53
Identities = 104/180 (57%), Positives = 141/180 (78%), Gaps = 2/180 (1%)
Query: 1095 LLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANI 1154
++D +I+ LNV+ R H+G+VSQEP+LF +I+ NI YG + V+ EE+ RAA+EAN
Sbjct: 1 MVDENDIRALNVRHYRDHIGVVSQEPVLFGTTISNNIKYGRDD--VTDEEMERAAREANA 58
Query: 1155 HAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVV 1214
+ FI PNK++T VG+KG Q+SGGQKQRIAIARALVR P IL+LDEATSALD+ES+ V
Sbjct: 59 YDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAIARALVRNPKILILDEATSALDSESKSAV 118
Query: 1215 QEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1274
Q AL+KA +GRT IV+AHRLSTI++ADLIV ++G + E G H +L+A++G+Y+S+V Q
Sbjct: 119 QAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGMLAEKGAHAELMAKRGLYYSLVMSQ 178
>gi|171184400 ATP-binding cassette, sub-family B, member 10 [Homo
sapiens]
Length = 738
Score = 350 bits (898), Expect = 5e-96
Identities = 215/585 (36%), Positives = 325/585 (55%), Gaps = 19/585 (3%)
Query: 63 AGLP----LMMLVFGEMTDIFANAGNLEDLMSNITNRS---------DINDTGFFMNLEE 109
AGLP L+ L + E + A G L MS++ + S D+ T ++ +
Sbjct: 152 AGLPEARKLLGLAYPERRRLAAAVGFLT--MSSVISMSAPFFLGKIIDVIYTNPTVDYSD 209
Query: 110 DMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVG 169
++TR S + A I+V + R ++++R F +I+RQE+ +FD G
Sbjct: 210 NLTRLCLGLSAVFLCGAAANAIRVYLMQTSGQRIVNRLRTSLFSSILRQEVAFFDKTRTG 269
Query: 170 ELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSA 229
EL RL+ D + + + + + ++ A G + F L +L++ P + + A
Sbjct: 270 ELINRLSSDTALLGRSVTENLSDGLRAGAQASVGISMMFFVSPNLATFVLSVVPPVSIIA 329
Query: 230 AVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGI 289
++ + L T + A+A +AEE + +RTV AFG + E+E+Y ++ ++
Sbjct: 330 VIYGRYLRKLTKVTQDSLAQATQLAEERIGNVRTVRAFGKEMTEIEKYASKVDHVMQLAR 389
Query: 290 KKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQAS 349
K+A GA L + G L+ S ++G++ + S+G S
Sbjct: 390 KEAFARAGFFGATGLSGNLIVLSVLYKGGLLMGSAHMTVGELSSFLMYAFWVGISIGGLS 449
Query: 350 PSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKI 409
GA ++++++ +P + + +G LEF+NVHF+YP+R EV I
Sbjct: 450 SFYSELMKGLGAGGRLWELLEREPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPI 509
Query: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
+ +L + SG ALVG SG GKST + L+ RLYDP G +S+DG DIR +N +LR
Sbjct: 510 FQDFSLSIPSGSVTALVGPSGSGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSK 569
Query: 470 IGVVSQEPVLFATTIAENIRYGREN---VTMDEIEKAVKEANAYDFIMKLPHKFDTLVGE 526
IG VSQEP+LF+ +IAENI YG ++ VT +EI++ + ANA FI P F+T+VGE
Sbjct: 570 IGTVSQEPILFSCSIAENIAYGADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGE 629
Query: 527 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIA 586
+G LSGGQKQRIAIARAL++NPKILLLDEATSALD E+E +VQ ALD+ GRT +VIA
Sbjct: 630 KGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIA 689
Query: 587 HRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLVTMQT 630
HRLST++NA+++A D G I E G H+EL+ K GIY KL+ Q+
Sbjct: 690 HRLSTIKNANMVAVLDQGKITEYGKHEELLSKPNGIYRKLMNKQS 734
Score = 335 bits (858), Expect = 2e-91
Identities = 203/504 (40%), Positives = 303/504 (60%), Gaps = 16/504 (3%)
Query: 780 AGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQN 839
+G+ + RLR +F S+LRQ+V++FD K TG L RL++D A + ++ L+ +
Sbjct: 239 SGQRIVNRLRTSLFSSILRQEVAFFD--KTRTGELINRLSSDTALLGRSVTENLSDGLRA 296
Query: 840 IANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATE 899
A GI + F L +L++VP ++I V+ + L + L + ++A E
Sbjct: 297 GAQASVGISMMFFVSPNLATFVLSVVPPVSIIAVIYGRYLRKLTKVTQDSLAQATQLAEE 356
Query: 900 AIENFRTVVS----LTQEQKFEHMYAQSLQVPYRNSLRKAHIFGIT-FSFTQAMMYFSYA 954
I N RTV + +T+ +K+ +Q+ + + +A FG T S ++ Y
Sbjct: 357 RIGNVRTVRAFGKEMTEIEKYASKVDHVMQLARKEAFARAGFFGATGLSGNLIVLSVLYK 416
Query: 955 GCFRFG-AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIE 1013
G G A++ +L SF L+++ V +++G +SSF + K + + ++E
Sbjct: 417 GGLLMGSAHMTVGELSSF----LMYAFWV--GISIGGLSSFYSELMKGLGAGGRLWELLE 470
Query: 1014 KTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSG 1073
+ P + L + +G + F V F YP RP++P+ Q SL + G ALVG SG
Sbjct: 471 REPKLPFNEGVILNEKSFQGALEFKNVHFAYPARPEVPIFQDFSLSIPSGSVTALVGPSG 530
Query: 1074 CGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAY 1133
GKSTV+ LL R YDP +G + LDG +I++LN WLR+ +G VSQEPILF CSIAENIAY
Sbjct: 531 SGKSTVLSLLLRLYDPASGTISLDGHDIRQLNPVWLRSKIGTVSQEPILFSCSIAENIAY 590
Query: 1134 G-DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVR 1192
G D+ V+ EEI R A+ AN AFI + P ++T VG+KG LSGGQKQRIAIARAL++
Sbjct: 591 GADDPSSVTAEEIQRVAEVANAVAFIRNFPQGFNTVVGEKGVLLSGGQKQRIAIARALLK 650
Query: 1193 QPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVK 1252
P ILLLDEATSALD E+E +VQEALD+ +GRT +VIAHRLSTI+NA+++ V G++
Sbjct: 651 NPKILLLDEATSALDAENEYLVQEALDRLMDGRTVLVIAHRLSTIKNANMVAVLDQGKIT 710
Query: 1253 EHGTHQQLLAQ-KGIYFSMVSVQA 1275
E+G H++LL++ GIY +++ Q+
Sbjct: 711 EYGKHEELLSKPNGIYRKLMNKQS 734
>gi|156105685 ATP-binding cassette, sub-family B, member 8 [Homo
sapiens]
Length = 718
Score = 325 bits (833), Expect = 2e-88
Identities = 213/588 (36%), Positives = 320/588 (54%), Gaps = 22/588 (3%)
Query: 697 FWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFS 756
FW+ + +L VV A + P +++ +TR ++ NL +
Sbjct: 120 FWQFLHPHLLVLGVAVVLALGAALVNVQIPLLLGQLVEVVAKYTRDHVGSFMTESQNLST 179
Query: 757 LLFLALGIISFITFFLQGFT--FGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGAL 814
L + G+ +TF G+ GE + +R +F S+LRQD+++FD N TG L
Sbjct: 180 HLLILYGVQGLLTF---GYLVLLSHVGERMAVDMRRALFSSLLRQDITFFD--ANKTGQL 234
Query: 815 TTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVV 874
+RL D + K + ++ ++ + ++ + +LTLLL+ P + G +
Sbjct: 235 VSRLTTDVQEFKSSFKLVISQGLRSCTQVAGCLVSLSMLSTRLTLLLMVATPALMGVGTL 294
Query: 875 EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRK 934
L + + ++++ + +A EA+ N RTV + EQ+ E Y L+ +
Sbjct: 295 MGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREEERYGAELEA----CRCR 350
Query: 935 AHIFGITFSFTQAMMYFSY----AGCFRFGAYLVAHKLMSFEDVL--LVFSAVVFGAMAV 988
A G + Q + ++ G G LVA + ++ D++ LV S V +MA
Sbjct: 351 AEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTGGDLMSFLVASQTVQRSMA- 409
Query: 989 GQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRP 1048
+S + + A + + P I + L G+VTF V F+YP RP
Sbjct: 410 -NLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQLRGSVTFQNVCFSYPCRP 468
Query: 1049 DIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQW 1108
VL+ +L + G+ +ALVG SG GK+TV LLERFYDP AG V+LDG++++ L+ W
Sbjct: 469 GFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVMLDGRDLRTLDPSW 528
Query: 1109 LRAHL-GIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYST 1167
LR + G +SQEP+LF +I ENI +G S EE+ AA+EAN H FI S P Y+T
Sbjct: 529 LRGQVVGFISQEPVLFGTTIMENIRFGKLE--ASDEEVYTAAREANAHEFITSFPEGYNT 586
Query: 1168 KVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTC 1227
VG++GT LSGGQKQR+AIARAL++QP +L+LDEATSALD ESE+VVQEALD+A GRT
Sbjct: 587 VVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESERVVQEALDRASAGRTV 646
Query: 1228 IVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275
+VIAHRLST++ A IVV +GRV E GTH++LL + G+Y ++ QA
Sbjct: 647 LVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIRRQA 694
Score = 319 bits (817), Expect = 1e-86
Identities = 212/602 (35%), Positives = 325/602 (53%), Gaps = 35/602 (5%)
Query: 36 VFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNR 95
+F F + + L VV L A + +PL++ G L ++++ T
Sbjct: 119 LFWQFLHPHLLVLGVAVVLALGAALVNVQIPLLL-------------GQLVEVVAKYTR- 164
Query: 96 SDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAI 155
+ G FM ++++ + G+ G+L Y+ + R +R+ F ++
Sbjct: 165 ---DHVGSFMTESQNLSTHLLILYGV-QGLLTFGYLVLLSH--VGERMAVDMRRALFSSL 218
Query: 156 MRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTR-GWKL 214
+RQ+I +FD + G+L +RLT DV + I +S T G +V + +L
Sbjct: 219 LRQDITFFDANKTGQLVSRLTTDVQEFKSSFKLVISQGLRS-CTQVAGCLVSLSMLSTRL 277
Query: 215 TLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKEL 274
TL+++ +P L + L + + A+A VA+E L +RTV AF +++E
Sbjct: 278 TLLLMVATPALMGVGTLMGSGLRKLSRQCQEQIARAMGVADEALGNVRTVRAFAMEQREE 337
Query: 275 ERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTV 334
ERY LE + + G A ++ A TL + G GQ LT
Sbjct: 338 ERYGAELEACR------CRAEELGRGIALFQGLSNIAFNCMVLGTLFIGGSLVAGQQLTG 391
Query: 335 --FFSVLIGAFSVGQASPSIEAFAN--ARG--AAYEIFKIIDNKPSIDSYSKSGHKPDNI 388
S L+ + +V ++ ++ RG A +F+ + P I + +
Sbjct: 392 GDLMSFLVASQTVQRSMANLSVLFGQVVRGLSAGARVFEYMALNPCIPLSGGCCVPKEQL 451
Query: 389 KGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTE 448
+G++ F+NV FSYP R ++LK L + G+ VALVG SG GK+T L++R YDPT
Sbjct: 452 RGSVTFQNVCFSYPCRPGFEVLKDFTLTLPPGKIVALVGQSGGGKTTVASLLERFYDPTA 511
Query: 449 GMVSVDGQDIRTINVRFLR-EIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEA 507
G+V +DG+D+RT++ +LR +++G +SQEPVLF TTI ENIR+G+ + +E+ A +EA
Sbjct: 512 GVVMLDGRDLRTLDPSWLRGQVVGFISQEPVLFGTTIMENIRFGKLEASDEEVYTAAREA 571
Query: 508 NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEA 567
NA++FI P ++T+VGERG LSGGQKQR+AIARAL++ P +L+LDEATSALD ESE
Sbjct: 572 NAHEFITSFPEGYNTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESER 631
Query: 568 VVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVT 627
VVQ ALD+A GRT +VIAHRLSTVR A I DG + E G H+EL+K+ G+Y +L+
Sbjct: 632 VVQEALDRASAGRTVLVIAHRLSTVRGAHCIVVMADGRVWEAGTHEELLKKGGLYAELIR 691
Query: 628 MQ 629
Q
Sbjct: 692 RQ 693
>gi|9955966 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 317 bits (813), Expect = 4e-86
Identities = 180/526 (34%), Positives = 302/526 (57%), Gaps = 14/526 (2%)
Query: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
+ G AA I+ + L R ++R F +++ QE +FD + G+L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
Query: 181 KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT 240
+++ + I +F ++ + F+ W+L+LV P++ + + ++ K +
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
Query: 241 DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG 300
+ A A+A AEE ++A++TV +F +++E E Y + L++ ++ K+A +
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
Query: 301 AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSI----EAFA 356
+ L + +YG LV+SG+ + G ++ + +I F +G S+
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLI----AFIIYEFVLGDCMESVGSVYSGLM 470
Query: 357 NARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLK 416
GAA ++F+ ID +P++ PD+++G ++F NV F+Y +R ++L+ ++
Sbjct: 471 QGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFS 528
Query: 417 VQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQE 476
+ G+ ALVG SG GKS+ V +++ Y G V +DG+ I + ++L +I +VSQE
Sbjct: 529 LSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQE 588
Query: 477 PVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQK 536
PVLFA +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQK
Sbjct: 589 PVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQK 648
Query: 537 QRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNAD 596
QR+A+ARALVRNP +L+LDEATSALD ESE ++Q A+ + T ++IAHRLSTV +A
Sbjct: 649 QRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAH 708
Query: 597 VIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAAD 642
+I D G +V++G H +L+ + G+Y KLV Q G L+ AAD
Sbjct: 709 LIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLG----LQPAAD 750
Score = 306 bits (783), Expect = 1e-82
Identities = 192/499 (38%), Positives = 278/499 (55%), Gaps = 22/499 (4%)
Query: 784 LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANL 843
L RLR +FRS++ Q+ S+FD+ N TG L +RL +D V + + V +N +
Sbjct: 257 LNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKV 314
Query: 844 GTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIEN 903
++ F WQL+L+ PII + + K + + + L + A E I
Sbjct: 315 TGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISA 374
Query: 904 FRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-------GITFSFTQAMMYFSYAGC 956
+TV S E++ +Y + LQ Y+ + ++A + G+T Q + + Y G
Sbjct: 375 MKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-YGGH 433
Query: 957 FRFGAYLVAHKLMSFEDVLLVFSAVVFGAM-AVGQVSSFAPDYAKAKISAAHIIMIIEKT 1015
+ + L++F +++ V+ M +VG V S A A + I++
Sbjct: 434 LVISGQMTSGNLIAF----IIYEFVLGDCMESVGSVYSGLMQGVGA---AEKVFEFIDRQ 486
Query: 1016 PLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCG 1075
P + L P+ LEG V F V F Y TRP VLQ +S + G+ ALVG SG G
Sbjct: 487 PTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSG 544
Query: 1076 KSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGD 1135
KS+ V +LE FY G+VLLDGK I + ++L + +VSQEP+LF SI +NI+YG
Sbjct: 545 KSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG- 603
Query: 1136 NSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPH 1195
V E +V AA++AN H FI L + YST+ G+KG QLSGGQKQR+A+ARALVR P
Sbjct: 604 -LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPP 662
Query: 1196 ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHG 1255
+L+LDEATSALD ESE ++Q+A+ + T ++IAHRLST+++A LIVV GRV + G
Sbjct: 663 VLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQG 722
Query: 1256 THQQLLAQKGIYFSMVSVQ 1274
THQQLLAQ G+Y +V Q
Sbjct: 723 THQQLLAQGGLYAKLVQRQ 741
>gi|45243524 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 1 [Homo sapiens]
Length = 766
Score = 317 bits (813), Expect = 4e-86
Identities = 180/526 (34%), Positives = 302/526 (57%), Gaps = 14/526 (2%)
Query: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
+ G AA I+ + L R ++R F +++ QE +FD + G+L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
Query: 181 KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT 240
+++ + I +F ++ + F+ W+L+LV P++ + + ++ K +
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
Query: 241 DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG 300
+ A A+A AEE ++A++TV +F +++E E Y + L++ ++ K+A +
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVW 414
Query: 301 AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSI----EAFA 356
+ L + +YG LV+SG+ + G ++ + +I F +G S+
Sbjct: 415 GSGLTLLVVQVSILYYGGHLVISGQMTSGNLI----AFIIYEFVLGDCMESVGSVYSGLM 470
Query: 357 NARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLK 416
GAA ++F+ ID +P++ PD+++G ++F NV F+Y +R ++L+ ++
Sbjct: 471 QGVGAAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFS 528
Query: 417 VQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQE 476
+ G+ ALVG SG GKS+ V +++ Y G V +DG+ I + ++L +I +VSQE
Sbjct: 529 LSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQE 588
Query: 477 PVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQK 536
PVLFA +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQK
Sbjct: 589 PVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQK 648
Query: 537 QRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNAD 596
QR+A+ARALVRNP +L+LDEATSALD ESE ++Q A+ + T ++IAHRLSTV +A
Sbjct: 649 QRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAH 708
Query: 597 VIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAAD 642
+I D G +V++G H +L+ + G+Y KLV Q G L+ AAD
Sbjct: 709 LIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLG----LQPAAD 750
Score = 306 bits (783), Expect = 1e-82
Identities = 192/499 (38%), Positives = 278/499 (55%), Gaps = 22/499 (4%)
Query: 784 LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANL 843
L RLR +FRS++ Q+ S+FD+ N TG L +RL +D V + + V +N +
Sbjct: 257 LNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKV 314
Query: 844 GTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIEN 903
++ F WQL+L+ PII + + K + + + L + A E I
Sbjct: 315 TGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISA 374
Query: 904 FRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIF-------GITFSFTQAMMYFSYAGC 956
+TV S E++ +Y + LQ Y+ + ++A + G+T Q + + Y G
Sbjct: 375 MKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILY-YGGH 433
Query: 957 FRFGAYLVAHKLMSFEDVLLVFSAVVFGAM-AVGQVSSFAPDYAKAKISAAHIIMIIEKT 1015
+ + L++F +++ V+ M +VG V S A A + I++
Sbjct: 434 LVISGQMTSGNLIAF----IIYEFVLGDCMESVGSVYSGLMQGVGA---AEKVFEFIDRQ 486
Query: 1016 PLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCG 1075
P + L P+ LEG V F V F Y TRP VLQ +S + G+ ALVG SG G
Sbjct: 487 PTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSG 544
Query: 1076 KSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGD 1135
KS+ V +LE FY G+VLLDGK I + ++L + +VSQEP+LF SI +NI+YG
Sbjct: 545 KSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG- 603
Query: 1136 NSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPH 1195
V E +V AA++AN H FI L + YST+ G+KG QLSGGQKQR+A+ARALVR P
Sbjct: 604 -LPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPP 662
Query: 1196 ILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHG 1255
+L+LDEATSALD ESE ++Q+A+ + T ++IAHRLST+++A LIVV GRV + G
Sbjct: 663 VLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQG 722
Query: 1256 THQQLLAQKGIYFSMVSVQ 1274
THQQLLAQ G+Y +V Q
Sbjct: 723 THQQLLAQGGLYAKLVQRQ 741
>gi|9955968 ATP-binding cassette, sub-family B (MDR/TAP), member 9
isoform 2 [Homo sapiens]
Length = 723
Score = 296 bits (759), Expect = 6e-80
Identities = 176/522 (33%), Positives = 291/522 (55%), Gaps = 49/522 (9%)
Query: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
+ G AA I+ + L R ++R F +++ QE +FD + G+L +RLT D +
Sbjct: 235 LAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTT 294
Query: 181 KINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFT 240
+++ + I +F ++ + F+ W+L+LV P++ + + ++ K +
Sbjct: 295 MVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLS 354
Query: 241 DKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIG 300
+ A A+A AEE ++A++TV +F +++E E Y + L++ ++ K+A
Sbjct: 355 KEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA-------- 406
Query: 301 AAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARG 360
A+Y W G S+G +V+ ++ G G
Sbjct: 407 -------AAYMYYVW--------GSGSVG---SVYSGLMQGV-----------------G 431
Query: 361 AAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSG 420
AA ++F+ ID +P++ PD+++G ++F NV F+Y +R ++L+ ++ + G
Sbjct: 432 AAEKVFEFIDRQPTM--VHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPG 489
Query: 421 QTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLF 480
+ ALVG SG GKS+ V +++ Y G V +DG+ I + ++L +I +VSQEPVLF
Sbjct: 490 KVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLF 549
Query: 481 ATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIA 540
A +I +NI YG V + + +A ++ANA+ FIM+L + T GE+GAQLSGGQKQR+A
Sbjct: 550 ARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVA 609
Query: 541 IARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAG 600
+ARALVRNP +L+LDEATSALD ESE ++Q A+ + T ++IAHRLSTV +A +I
Sbjct: 610 MARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVV 669
Query: 601 FDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAAD 642
D G +V++G H +L+ + G+Y KLV Q G L+ AAD
Sbjct: 670 LDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLG----LQPAAD 707
Score = 295 bits (756), Expect = 1e-79
Identities = 188/491 (38%), Positives = 265/491 (53%), Gaps = 49/491 (9%)
Query: 784 LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANL 843
L RLR +FRS++ Q+ S+FD+ N TG L +RL +D V + + V +N +
Sbjct: 257 LNIRLRNCLFRSLVSQETSFFDE--NRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKV 314
Query: 844 GTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIEN 903
++ F WQL+L+ PII + + K + + + L + A E I
Sbjct: 315 TGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISA 374
Query: 904 FRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYL 963
+TV S E++ +Y + LQ Y+ + ++A A MY+
Sbjct: 375 MKTVRSFANEEEEAEVYLRKLQQVYKLNRKEA----------AAYMYY------------ 412
Query: 964 VAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYST 1023
V+G+ +VG V S A A + I++ P +
Sbjct: 413 ------------------VWGSGSVGSVYSGLMQGVGA---AEKVFEFIDRQPTM--VHD 449
Query: 1024 EGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 1083
L P+ LEG V F V F Y TRP VLQ +S + G+ ALVG SG GKS+ V +L
Sbjct: 450 GSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNIL 509
Query: 1084 ERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQE 1143
E FY G+VLLDGK I + ++L + +VSQEP+LF SI +NI+YG V E
Sbjct: 510 ENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYG--LPTVPFE 567
Query: 1144 EIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEAT 1203
+V AA++AN H FI L + YST+ G+KG QLSGGQKQR+A+ARALVR P +L+LDEAT
Sbjct: 568 MVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEAT 627
Query: 1204 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1263
SALD ESE ++Q+A+ + T ++IAHRLST+++A LIVV GRV + GTHQQLLAQ
Sbjct: 628 SALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQ 687
Query: 1264 KGIYFSMVSVQ 1274
G+Y +V Q
Sbjct: 688 GGLYAKLVQRQ 698
>gi|9665248 transporter 1, ATP-binding cassette, sub-family B [Homo
sapiens]
Length = 808
Score = 263 bits (672), Expect = 8e-70
Identities = 173/535 (32%), Positives = 282/535 (52%), Gaps = 17/535 (3%)
Query: 746 ETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFD 805
+T +N L S+L +A ++ F+ + T G + L+ VF ++LRQ+ +F
Sbjct: 282 DTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGH----VHSHLQGEVFGAVLRQETEFFQ 337
Query: 806 DPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW---QLTLLLL 862
+N TG + +R+ D + + ++ L++ + G+ + I W LT++ L
Sbjct: 338 --QNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVR---GLCLLGIMLWGSVSLTMVTL 392
Query: 863 AIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQ 922
+P++ + K ++ ++ L S ++A EA+ TV S E+ + +
Sbjct: 393 ITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFRE 452
Query: 923 SLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVV 982
LQ + ++A + + T G G LV +S +++ +
Sbjct: 453 KLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQM 512
Query: 983 FGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVF 1042
AV + S P KA S+ I +++TP L P LEG V F +V F
Sbjct: 513 QFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGL--LTPLHLEGLVQFQDVSF 570
Query: 1043 NYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIK 1102
YP RPD+ VLQGL+ ++ G+ ALVG +G GKSTV LL+ Y P G++LLDGK +
Sbjct: 571 AYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLP 630
Query: 1103 RLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLP 1162
+ ++L + V QEP +F S+ ENIAYG + + EEI AA ++ H+FI LP
Sbjct: 631 QYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQK-PTMEEITAAAVKSGAHSFISGLP 689
Query: 1163 NKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKA- 1221
Y T+V + G+QLSGGQ+Q +A+ARAL+R+P +L+LD+ATSALD S+ V++ L ++
Sbjct: 690 QGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESP 749
Query: 1222 -REGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQA 1275
R R+ ++I LS ++ AD I+ + G ++E GTHQQL+ +KG Y++MV A
Sbjct: 750 ERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPA 804
Score = 254 bits (649), Expect = 4e-67
Identities = 157/486 (32%), Positives = 262/486 (53%), Gaps = 11/486 (2%)
Query: 147 IRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIV 206
++ + F A++RQE +F + G + +R+T+D S +++ + + + +F + +
Sbjct: 320 LQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGI 379
Query: 207 GFTRGWKLTLVILAISPVLGL---SAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRT 263
LT+V L P+L L W ++L + L AK+ VA E L+A+ T
Sbjct: 380 MLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESL---AKSSQVAIEALSAMPT 436
Query: 264 VIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLS 323
V +F ++ E +++ + L+E K + K+A+ ++ + + G LV S
Sbjct: 437 VRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTS 496
Query: 324 GEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGH 383
G S G ++T + +V A G++ +IF+ +D P
Sbjct: 497 GAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLL-- 554
Query: 384 KPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRL 443
P +++G ++F++V F+YP+R +V +L+GL ++ G+ ALVG +G GKST L+Q L
Sbjct: 555 TPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNL 614
Query: 444 YDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYG-RENVTMDEIEK 502
Y PT G + +DG+ + R+L + V QEP +F ++ ENI YG + TM+EI
Sbjct: 615 YQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITA 674
Query: 503 AVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALD 562
A ++ A+ FI LP +DT V E G+QLSGGQ+Q +A+ARAL+R P +L+LD+ATSALD
Sbjct: 675 AAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALD 734
Query: 563 TESEAVVQVALDKA--RKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKG 620
S+ V+ L ++ R R+ ++I LS V AD I + G I E G H +LM++KG
Sbjct: 735 ANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKG 794
Query: 621 IYFKLV 626
Y+ +V
Sbjct: 795 CYWAMV 800
>gi|73747915 transporter 2, ATP-binding cassette, sub-family B
isoform 1 [Homo sapiens]
Length = 703
Score = 245 bits (625), Expect = 2e-64
Identities = 159/488 (32%), Positives = 272/488 (55%), Gaps = 21/488 (4%)
Query: 146 KIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATF--FTG 203
+IR+Q F +++RQ++G+F GELN+RL+ D + ++ + + +S+ G
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVW----AKILSSFTDKELLAYAKAGAVAEEVLA 259
F++ + +LTL+ L P + V+ ++L D A A+AG V E +
Sbjct: 284 FMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVARAGQVVREAVG 337
Query: 260 AIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTT 319
++TV +FG ++ E+ RY + LE+ +++ ++ + + + +L L G
Sbjct: 338 GLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ 397
Query: 320 LVLSGEYSIGQVLT-VFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSY 378
+ GE + G +L+ + + +G++ + +N GAA ++F +D +P++ S
Sbjct: 398 QMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLPSP 456
Query: 379 SKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQ 438
P ++G ++F++V F+YP+R + +LKGL ++ G+ ALVG +G GKST
Sbjct: 457 GTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAA 514
Query: 439 LMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMD 498
L+Q LY PT G V +D + I +L + V QEPVLF+ ++ NI YG ++ D
Sbjct: 515 LLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDD 574
Query: 499 EIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 558
++ A + A+A DFI ++ H T VGE+G+QL+ GQKQR+AIARALVR+P++L+LDEAT
Sbjct: 575 KVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEAT 634
Query: 559 SALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKE 618
SALD + E +Q +R RT +VIAHRL V+ A I +G + + +L +
Sbjct: 635 SALDVQCEQALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQKLA---QLQEG 689
Query: 619 KGIYFKLV 626
+ +Y +LV
Sbjct: 690 QDLYSRLV 697
Score = 236 bits (602), Expect = 1e-61
Identities = 179/581 (30%), Positives = 290/581 (49%), Gaps = 56/581 (9%)
Query: 695 VSFWRIMKLNLTEWPYFVVGVF---CAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQN 751
V WR++KL+ + P V F A++ L P ++ ++I + DP
Sbjct: 136 VLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDPHAFA-- 190
Query: 752 SNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTT 811
S +F + + G S ++ +G F + R+R +F S+LRQD+ +F + K T
Sbjct: 191 SAIFFMCLFSFG--SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--T 246
Query: 812 GALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW------QLTLLLLAIV 865
G L +RL++D + + V+ +++ + +YG+ +LTLL L +
Sbjct: 247 GELNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHM 300
Query: 866 PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQ----KFEHMYA 921
P A V + + + +G++ EA+ +TV S E+ +++
Sbjct: 301 PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE 360
Query: 922 QSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK--LMSFEDVLLVFS 979
Q Q+ +R L +A +Y G ++ L +D L
Sbjct: 361 QCRQLYWRRDLERA-------------LYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407
Query: 980 AVVFGAMAVGQVSSFAP-------DYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLE 1032
+++ + V S+ D +A + +++ P + S T L P TL+
Sbjct: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQ 465
Query: 1033 GNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1092
G V F +V F YP RPD PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G
Sbjct: 466 GVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGG 525
Query: 1093 KVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA 1152
+VLLD K I + +L + + V QEP+LF S+ NIAYG S ++++ AA+ A
Sbjct: 526 QVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAA 583
Query: 1153 NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1212
+ FI+ + + T VG+KG+QL+ GQKQR+AIARALVR P +L+LDEATSALD + E+
Sbjct: 584 HADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQ 643
Query: 1213 VVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKE 1253
+Q+ +R RT +VIAHRL +Q A I+V Q G++++
Sbjct: 644 ALQDW--NSRGDRTVLVIAHRLQAVQRAHQILVLQEGKLQK 682
>gi|9955963 ATP-binding cassette, sub-family B, member 6 [Homo
sapiens]
Length = 842
Score = 240 bits (613), Expect = 6e-63
Identities = 167/447 (37%), Positives = 231/447 (51%), Gaps = 44/447 (9%)
Query: 208 FTRGWKLTLVILAISPVLGLSAAV--W-AKILSSFTDKELLAYAKAGAVAEEVLAAIRTV 264
F W +V L +S L L+ V W K + +E A+A + L TV
Sbjct: 408 FFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQENATRARA----VDSLLNFETV 463
Query: 265 IAFGGQKKELERYNKNLEEAKRIGIKKAI-------TANISIGAAFLLIYASYALAFWYG 317
+ + E+ERY + + + + + K + T N+ IG L+ S A++
Sbjct: 464 KYYNAESYEVERYREAIIKYQGLEWKSSASLVLLNQTQNLVIGLG--LLAGSLLCAYFVT 521
Query: 318 TTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFK--IIDNKPSI 375
+ G+Y VL G + + P N G Y + + ID +
Sbjct: 522 EQKLQVGDY-----------VLFGTYIIQLYMP-----LNWFGTYYRMIQTNFIDMENMF 565
Query: 376 DSYSKSGHKPDNI--------KGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 427
D + D KG +EF NVHFSY +E L+ ++ V GQT+ALVG
Sbjct: 566 DLLKEETEVKDLPGAGPLRFQKGRIEFENVHFSYADGRET--LQDVSFTVMPGQTLALVG 623
Query: 428 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 487
SG GKST ++L+ R YD + G + +DGQDI + LR IGVV Q+ VLF TIA+N
Sbjct: 624 PSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTIADN 683
Query: 488 IRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVR 547
IRYGR DE+E A + A +D IM P + T VGERG +LSGG+KQR+AIAR +++
Sbjct: 684 IRYGRVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAIARTILK 743
Query: 548 NPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIV 607
P I+LLDEATSALDT +E +Q +L K RTTIV+AHRLSTV NAD I DG IV
Sbjct: 744 APGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVIKDGCIV 803
Query: 608 EKGNHDELMKEKGIYFKLVTMQTAGNE 634
E+G H+ L+ G+Y + +Q E
Sbjct: 804 ERGRHEALLSRGGVYADMWQLQQGQEE 830
Score = 221 bits (564), Expect = 3e-57
Identities = 155/510 (30%), Positives = 269/510 (52%), Gaps = 16/510 (3%)
Query: 772 LQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGS 831
L+ F + + + ++R+ ++F + + W + TG + + V G +
Sbjct: 329 LRTFLWIRVQQFTSRRVELLIFSHLHELSLRWHLGRR--TGEVLRIADRGTSSVTGLLSY 386
Query: 832 RLAVITQNIANLGTGIII--SFIYGWQLTLLLLAIVPIIAIAGVV-EMKMLSGQALKDKK 888
+ + +A++ GII F W ++ L + + + VV E + +A+ ++
Sbjct: 387 LVFNVIPTLADIIIGIIYFSMFFNAWFGLIVFLCMSLYLTLTIVVTEWRTKFRRAMNTQE 446
Query: 889 ELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAM 948
+ A +++ NF TV E Y +++ + Y+ K+ + + TQ +
Sbjct: 447 NATRAR--AVDSLLNFETVKYYNAESYEVERYREAI-IKYQGLEWKSSASLVLLNQTQNL 503
Query: 949 MY-FSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAH 1007
+ AY V + + D +L + ++ M + ++ I +
Sbjct: 504 VIGLGLLAGSLLCAYFVTEQKLQVGDYVLFGTYIIQLYMPLNWFGTYYRMIQTNFIDMEN 563
Query: 1008 IIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLA 1067
+ ++++ + G + +G + F V F+Y + LQ +S V GQTLA
Sbjct: 564 MFDLLKEETEVKDLPGAGPL-RFQKGRIEFENVHFSYADGRE--TLQDVSFTVMPGQTLA 620
Query: 1068 LVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSI 1127
LVG SG GKST+++LL RFYD +G + +DG++I ++ LR+H+G+V Q+ +LF+ +I
Sbjct: 621 LVGPSGAGKSTILRLLFRFYDISSGCIRIDGQDISQVTQASLRSHIGVVPQDTVLFNDTI 680
Query: 1128 AENIAYGDNSRVVS-QEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAI 1186
A+NI YG RV + +E+ AA+ A IH I + P Y T+VG++G +LSGG+KQR+AI
Sbjct: 681 ADNIRYG---RVTAGNDEVEAAAQAAGIHDAIMAFPEGYRTQVGERGLKLSGGEKQRVAI 737
Query: 1187 ARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVF 1246
AR +++ P I+LLDEATSALDT +E+ +Q +L K RT IV+AHRLST+ NAD I+V
Sbjct: 738 ARTILKAPGIILLDEATSALDTSNERAIQASLAKVCANRTTIVVAHRLSTVVNADQILVI 797
Query: 1247 QNGRVKEHGTHQQLLAQKGIYFSMVSVQAG 1276
++G + E G H+ LL++ G+Y M +Q G
Sbjct: 798 KDGCIVERGRHEALLSRGGVYADMWQLQQG 827
>gi|4557481 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
[Homo sapiens]
Length = 1545
Score = 240 bits (612), Expect = 7e-63
Identities = 238/936 (25%), Positives = 414/936 (44%), Gaps = 88/936 (9%)
Query: 387 NIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDP 446
N ++F F++ E + + +NL + +GQ VA++G G GKS+ + M +
Sbjct: 632 NFDKAMQFSEASFTWEHDSEATV-RDVNLDIMAGQLVAVIGPVGSGKSSLISAMLGEMEN 690
Query: 447 TEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKE 506
G +++ G V Q+ + TI +NI +G E ++ ++
Sbjct: 691 VHGHITIKGTT-------------AYVPQQSWIQNGTIKDNILFGTE-FNEKRYQQVLEA 736
Query: 507 ANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-S 565
+ LP +GE+G LSGGQKQRI++ARA +N I LLD+ SA+D
Sbjct: 737 CALLPDLEMLPGGDLAEIGEKGINLSGGQKQRISLARATYQNLDIYLLDDPLSAVDAHVG 796
Query: 566 EAVVQVAL--DKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 623
+ + L + KG+T +++ H + + D I +G IVEKG++ L+ +KG +
Sbjct: 797 KHIFNKVLGPNGLLKGKTRLLVTHSMHFLPQVDEIVVLGNGTIVEKGSYSALLAKKGEFA 856
Query: 624 KLVT--MQTAGNEVEL-----ENAADESKSEIDALEMSSNDSRSSLIRK---------RS 667
K + ++ G E E D+ I ++E D+ S +R+ RS
Sbjct: 857 KNLKTFLRHTGPEEEATVHDGSEEEDDDYGLISSVEEIPEDAASITMRRENSFRRTLSRS 916
Query: 668 TRRSVRGSQAQDRKLSTKE--ALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIING-GL 724
+R + R ++ L T+ +L E V +++K E ++ + GL
Sbjct: 917 SRSNGRHLKSLRNSLKTRNVNSLKEDEELVKGQKLIKKEFIETGKVKFSIYLEYLQAIGL 976
Query: 725 QPAFAIIFSKIIG-------------------VFTRIDDPETKRQ-NSNLFSLLFLALGI 764
F II + ++ +F D P ++R ++ L LA GI
Sbjct: 977 FSIFFIILAFVMNSVAFIGSNLWLSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGI 1036
Query: 765 ISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQ 824
FI F F F A IL K+L ++LR + +FD TG + R A D +
Sbjct: 1037 FVFIAHFWSAFGFVHASNILHKQL----LNNILRAPMRFFDT--TPTGRIVNRFAGDIST 1090
Query: 825 VKGAIGSRL-AVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQA 883
V + L + IT + + T ++I + + ++P+ I V+M +S
Sbjct: 1091 VDDTLPQSLRSWITCFLGIISTLVMICMA----TPVFTIIVIPLGIIYVSVQMFYVS--- 1143
Query: 884 LKDKKELEGSGKIATEAIENF--RTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGIT 941
++L + I + TV L + FEH R + +F
Sbjct: 1144 --TSRQLRRLDSVTRSPIYSHFSETVSGLPVIRAFEHQQRFLKHNEVRIDTNQKCVFSWI 1201
Query: 942 FSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLL--VFSAVVFGAMAVGQVSSFA---P 996
S + G + A ++ + D L V+ A+ + Q ++
Sbjct: 1202 TSNRWLAIRLELVG--NLTVFFSALMMVIYRDTLSGDTVGFVLSNALNITQTLNWLVRMT 1259
Query: 997 DYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTL--EGNVTFGEVVFNYPTRPDIPVLQ 1054
+ I A I K + T+ P +G + F Y D+ VL+
Sbjct: 1260 SEIETNIVAVERITEYTKVENEAPWVTDKRPPPDWPSKGKIQFNNYQVRYRPELDL-VLR 1318
Query: 1055 GLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLG 1114
G++ ++ + + +VG +G GKS++ L R + G++++DG +I + + LR L
Sbjct: 1319 GITCDIGSMEKIGVVGRTGAGKSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLT 1378
Query: 1115 IVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGT 1174
I+ Q+PILF S+ N+ +N S EEI +A + A++ +F+ SL S +V + G
Sbjct: 1379 IIPQDPILFSGSLRMNLDPFNN---YSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGG 1435
Query: 1175 QLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRL 1234
LS GQ+Q + + RAL+R+ IL+LDEAT+A+D E++ ++Q + T I IAHRL
Sbjct: 1436 NLSIGQRQLLCLGRALLRKSKILVLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRL 1495
Query: 1235 STIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
TI ++D ++V NG++ E G+ ++LL G ++ M
Sbjct: 1496 HTIMDSDKVMVLDNGKIIECGSPEELLQIPGPFYFM 1531
Score = 160 bits (406), Expect = 6e-39
Identities = 142/551 (25%), Positives = 258/551 (46%), Gaps = 37/551 (6%)
Query: 89 MSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLV-AAYIQVSFWCLAAGRQIHKI 147
+S T+ S I ++ + + DM Y G+ G+ V A+ +F + A +HK
Sbjct: 1000 LSAWTSDSKIFNSTDYPASQRDMRVGVYGALGLAQGIFVFIAHFWSAFGFVHASNILHK- 1058
Query: 148 RKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVG 207
Q + I+R + +FD G + R D+S ++ D + +S T F G I
Sbjct: 1059 --QLLNNILRAPMRFFDTTPTGRIVNRFAGDISTVD----DTLPQSLRSWITCFLGIIST 1112
Query: 208 FTRGWKLTLVILAISPVLGL----------SAAVWAKILSSFTDKELLAYAKAGAVAEEV 257
T V I LG+ S + + L S T + ++ E
Sbjct: 1113 LVMICMATPVFTIIVIPLGIIYVSVQMFYVSTSRQLRRLDSVTRSPIYSHFS------ET 1166
Query: 258 LAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAF-----LLIYASYAL 312
++ + + AF Q++ L+ ++ ++ + IT+N + L ++ S +
Sbjct: 1167 VSGLPVIRAFEHQQRFLKHNEVRIDTNQKC-VFSWITSNRWLAIRLELVGNLTVFFSALM 1225
Query: 313 AFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNK 372
Y TL SG+ ++G VL+ ++ + + + IE A E K+ +
Sbjct: 1226 MVIYRDTL--SGD-TVGFVLSNALNITQTLNWLVRMTSEIETNIVAVERITEYTKVENEA 1282
Query: 373 PSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCG 432
P + P KG ++F N Y ++ +L+G+ + S + + +VG +G G
Sbjct: 1283 PWVTDKRPPPDWPS--KGKIQFNNYQVRYRPELDL-VLRGITCDIGSMEKIGVVGRTGAG 1339
Query: 433 KSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGR 492
KS+ + R+ + G + +DG DI +I + LRE + ++ Q+P+LF+ ++ N+
Sbjct: 1340 KSSLTNCLFRILEAAGGQIIIDGVDIASIGLHDLREKLTIIPQDPILFSGSLRMNLD-PF 1398
Query: 493 ENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL 552
N + +EI KA++ A+ F+ L V E G LS GQ+Q + + RAL+R KIL
Sbjct: 1399 NNYSDEEIWKALELAHLKSFVASLQLGLSHEVTEAGGNLSIGQRQLLCLGRALLRKSKIL 1458
Query: 553 LLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNH 612
+LDEAT+A+D E++ ++Q + T I IAHRL T+ ++D + D+G I+E G+
Sbjct: 1459 VLDEATAAVDLETDNLIQTTIQNEFAHCTVITIAHRLHTIMDSDKVMVLDNGKIIECGSP 1518
Query: 613 DELMKEKGIYF 623
+EL++ G ++
Sbjct: 1519 EELLQIPGPFY 1529
>gi|89111135 ATP-binding cassette protein C12 [Homo sapiens]
Length = 1359
Score = 240 bits (612), Expect = 7e-63
Identities = 264/1150 (22%), Positives = 488/1150 (42%), Gaps = 151/1150 (13%)
Query: 218 ILAISPVLGLSAAV--------WAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGG 269
IL + ++G+S V AK+ S+F +L K E L IR + +
Sbjct: 258 ILGPTALIGISVYVIFIPVQMFMAKLNSAFRRSAILVTDKRVQTMNEFLTCIRLIKMYAW 317
Query: 270 QKKELERYNKNLEEAKRIGIKKAITANI--SIGAAFLLIYASYALAFWYGTTLVLSGEYS 327
+K + +++ +R K A S +A I ++ A+ ++L + +
Sbjct: 318 EKS----FTNTIQDIRRRERKLLEKAGFVQSGNSALAPIVSTIAIVLTLSCHILLRRKLT 373
Query: 328 IGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDN 387
+V + FS+ SI+A A A + + KI+ +K S SY PD
Sbjct: 374 APVAFSVIAMFNVMKFSIAILPFSIKAMAEANVSLRRMKKILIDK-SPPSYITQPEDPDT 432
Query: 388 I-------------------KGNLEFRNVHFSYPSRKEV--------------------- 407
+ L+ + H R E
Sbjct: 433 VLLLANATLTWEHEASRKSTPKKLQNQKRHLCKKQRSEAYSERSPPAKGATGPEEQSDSL 492
Query: 408 -KILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFL 466
+L ++ V+ G+ + + GN G GKS+ + + +G+V+V+G
Sbjct: 493 KSVLHSISFVVRKGKILGICGNVGSGKSSLLAALLGQMQLQKGVVAVNGT---------- 542
Query: 467 REIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGE 526
+ VSQ+ +F + ENI +G E + V+ + LP+ T +GE
Sbjct: 543 ---LAYVSQQAWIFHGNVRENILFG-EKYDHQRYQHTVRVCGLQKDLSNLPYGDLTEIGE 598
Query: 527 RGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVI 585
RG LSGGQ+QRI++ARA+ + ++ LLD+ SA+D + V + + K +G+T +++
Sbjct: 599 RGLNLSGGQRQRISLARAVYSDRQLYLLDDPLSAVDAHVGKHVFEECIKKTLRGKTVVLV 658
Query: 586 AHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESK 645
H+L + + D + +DG I EKG H ELM+E+G Y KL+ + E+ + +
Sbjct: 659 THQLQFLESCDEVILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHLYNAAM 718
Query: 646 SEIDALEMSSNDSRSSLI------RKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSF-- 697
E + + + +I K + S GS+ D K+ + + P
Sbjct: 719 VEAFKESPAEREEDAGIIVLAPGNEKDEGKESETGSEFVDTKVPEHQLIQTESPQEGTVT 778
Query: 698 WRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVF----TRID-DPETKRQ-- 750
W+ + +++ +F + L A + +G++ +R+ P+ R
Sbjct: 779 WKTYHTYIKASGGYLLSLFTVFLFL-LMIGSAAFSNWWLGLWLDKGSRMTCGPQGNRTMC 837
Query: 751 ---------NSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDV 801
+++ ++ A + + +GF F K + + L VF +L+ +
Sbjct: 838 EVGAVLADIGQHVYQWVYTASMVFMLVFGVTKGFVFTKTTLMASSSLHDTVFDKILKSPM 897
Query: 802 SWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLL 861
S+FD TG L R + D + + RL +N ++ + L +
Sbjct: 898 SFFDT--TPTGRLMNRFSKDMDE----LDVRLPFHAENFLQQFFMVVFILVI---LAAVF 948
Query: 862 LAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYA 921
A++ ++A V +L +I ++ + V ++++ F H+
Sbjct: 949 PAVLLVVASLAVGFFILL---------------RIFHRGVQELKKVENVSRSPWFTHI-T 992
Query: 922 QSLQVPYRNSLRKAHIFGITFS-FTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLV--- 977
S+Q L H +G S T ++YF+ A + V +++F LLV
Sbjct: 993 SSMQ-----GLGIIHAYGKKESCITYHLLYFNCALRWFALRMDVLMNILTFTVALLVTLS 1047
Query: 978 FSAVVFGAMAVG-----------QVSSFAPDYAKAKISAAHIIMIIEKT--PLIDSYSTE 1024
FS++ + + QV +AK ++ ++ T P
Sbjct: 1048 FSSISTSSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSVELLREYISTCVPECTHPLKV 1107
Query: 1025 GLMPNTL--EGNVTFGEVVFNYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQ 1081
G P G +TF + Y R + P VL L+L ++ GQT+ +VG +G GKS++
Sbjct: 1108 GTCPKDWPSRGEITFRDYQMRY--RDNTPLVLDSLNLNIQSGQTVGIVGRTGSGKSSLGM 1165
Query: 1082 LLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVS 1141
L R +P +G + +D +I L+++ LR L ++ Q+P+LF ++ N+ D +
Sbjct: 1166 ALFRLVEPASGTIFIDEVDICILSLEDLRTKLTVIPQDPVLFVGTVRYNL---DPFESHT 1222
Query: 1142 QEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDE 1201
E + + + + I LP K +V + G S G++Q + +ARAL+R I+LLDE
Sbjct: 1223 DEMLWQVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCVARALLRNSKIILLDE 1282
Query: 1202 ATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLL 1261
AT+++D++++ +VQ + A +G T + IAHRL+T+ N D ++V +NG+V E + L
Sbjct: 1283 ATASMDSKTDTLVQNTIKDAFKGCTVLTIAHRLNTVLNCDHVLVMENGKVIEFDKPEVLA 1342
Query: 1262 AQKGIYFSMV 1271
+ F+M+
Sbjct: 1343 EKPDSAFAML 1352
>gi|66529005 ATP-binding cassette, sub-family C, member 5 isoform 1
[Homo sapiens]
Length = 1437
Score = 239 bits (611), Expect = 9e-63
Identities = 277/1199 (23%), Positives = 497/1199 (41%), Gaps = 204/1199 (17%)
Query: 211 GWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVA---------EEVLAAI 261
G ++IL + LG + + F + L AY + VA EVL I
Sbjct: 307 GMIYNVIILGPTGFLGSAVFILFYPAMMFASR-LTAYFRRKCVAATDERVQKMNEVLTYI 365
Query: 262 RTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLV 321
+ + + K + K EE +RI K +I++G A +++ + + F +
Sbjct: 366 KFIKMYAWVKAFSQSVQKIREEERRILEKAGYFQSITVGVAPIVVVIASVVTF--SVHMT 423
Query: 322 LSGEYSIGQ---VLTVF----FSVLIGAFSV---GQASPSIEAFA--------------- 356
L + + Q V+TVF F++ + FSV +AS +++ F
Sbjct: 424 LGFDLTAAQAFTVVTVFNSMTFALKVTPFSVKSLSEASVAVDRFKSLFLMEEVHMIKNKP 483
Query: 357 ----------NARGAAYEIFKIIDNKPSIDSYSK-----SGHKPDNI------------- 388
NA A I N P + K S K + +
Sbjct: 484 ASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKMKKDKRASRGKKEKVRQLQRTEHQAVLA 543
Query: 389 --KGNLEFRNVHFSYPSRKEVK-----------ILKGLNLKVQSGQTVALVGNSGCGKST 435
KG+L + P +E K L ++L++Q G+ V + G+ G GK++
Sbjct: 544 EQKGHLLLDSDERPSPEEEEGKHIHLGHLRLQRTLHSIDLEIQEGKLVGICGSVGSGKTS 603
Query: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
+ + EG +++ G V+Q+ + T+ +NI +G+E
Sbjct: 604 LISAILGQMTLLEGSIAISGT-------------FAYVAQQAWILNATLRDNILFGKE-Y 649
Query: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
+ + + LP T +GERGA LSGGQ+QRI++ARAL + I +LD
Sbjct: 650 DEERYNSVLNSCCLRPDLAILPSSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILD 709
Query: 556 EATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDE 614
+ SALD + A+ K K +T + + H+L + + D + +G I E+G H+E
Sbjct: 710 DPLSALDAHVGNHIFNSAIRKHLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEE 769
Query: 615 LMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRG 674
LM G Y + G E +E++S S +K + G
Sbjct: 770 LMNLNGDYATIFNNLLLG--------------ETPPVEINSKKETSGSQKKSQDKGPKTG 815
Query: 675 SQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSK 734
S +++ + +E ++ + P+ V GV+ G L AF +I +
Sbjct: 816 SVKKEKAVKPEEG--------QLVQLEEKGQGSVPWSVYGVYIQAAGGPL--AFLVIMAL 865
Query: 735 II----------------------------GVFTRIDDPETKRQNSNLFSLLFLALGIIS 766
+ G T + D + ++ ++ +
Sbjct: 866 FMLNVGSTAFSTWWLSYWIKQGSGNTTVTRGNETSVSDSMKDNPHMQYYASIYALSMAVM 925
Query: 767 FITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVK 826
I ++G F K + RL +FR +LR + +FD TG + R + D +V
Sbjct: 926 LILKAIRGVVFVKGTLRASSRLHDELFRRILRSPMKFFDT--TPTGRILNRFSKDMDEVD 983
Query: 827 GAIGSRLAVITQNIANLGTGI-IISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALK 885
+ + + QN+ + + +I+ ++ W L+A+ P++ + V+ + +S ++
Sbjct: 984 VRLPFQAEMFIQNVILVFFCVGMIAGVFPW----FLVAVGPLVILFSVLHI--VSRVLIR 1037
Query: 886 DKKELEGSGKIA-----TEAIENFRTVVSLTQEQKFEHMYAQSL---QVPYRNSLRKAHI 937
+ K L+ + T +I+ T+ + + Q+F H Y + L Q P+
Sbjct: 1038 ELKRLDNITQSPFLSHITSSIQGLATIHAYNKGQEFLHRYQELLDDNQAPF--------- 1088
Query: 938 FGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFS-----------AVVFGAM 986
F FT AM + + L++ L++ +++V A+ +
Sbjct: 1089 ----FLFTCAMRWLAVR------LDLISIALITTTGLMIVLMHGQIPPAYAGLAISYAVQ 1138
Query: 987 AVG--QVSSFAPDYAKAKISAAHIIMIIEKTPLIDS---YSTEGLMPN-TLEGNVTFGEV 1040
G Q + +A+ ++ I KT +++ + P+ EG VTF
Sbjct: 1139 LTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIKNKAPSPDWPQEGEVTFENA 1198
Query: 1041 VFNYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGK 1099
Y R ++P VL+ +S +K + + +VG +G GKS++ L R + G + +DG
Sbjct: 1199 EMRY--RENLPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGV 1256
Query: 1100 EIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIE 1159
I + + LR+ L I+ QEP+LF ++ N+ D ++++I A + ++ I
Sbjct: 1257 RISDIGLADLRSKLSIIPQEPVLFSGTVRSNL---DPFNQYTEDQIWDALERTHMKECIA 1313
Query: 1160 SLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1219
LP K ++V + G S G++Q + IARAL+R IL+LDEAT+A+DTE++ ++QE +
Sbjct: 1314 QLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIR 1373
Query: 1220 KAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTK 1278
+A T + IAHRL T+ +D I+V G+V E T LL+ F + A K
Sbjct: 1374 EAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVEFDTPSVLLSNDSSRFYAMFAAAENK 1432
Score = 150 bits (378), Expect = 1e-35
Identities = 140/533 (26%), Positives = 247/533 (46%), Gaps = 40/533 (7%)
Query: 94 NRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFH 153
N + ++D+ M M YA Y+ A +L+ I+ + R ++ + F
Sbjct: 897 NETSVSDS---MKDNPHMQYYASIYALSMAVMLILKAIRGVVFVKGTLRASSRLHDELFR 953
Query: 154 AIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRG-- 211
I+R + +FD G + R + D+ +++ + + MF Q++ F F VG G
Sbjct: 954 RILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVF--FCVGMIAGVF 1011
Query: 212 -WKLTLV--ILAISPVLGLSAAVW---AKILSSFTDKELLAYAKAGAVAEEVLAAIRTVI 265
W L V ++ + VL + + V K L + T L++ + + + T+
Sbjct: 1012 PWFLVAVGPLVILFSVLHIVSRVLIRELKRLDNITQSPFLSHITSS------IQGLATIH 1065
Query: 266 AFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGE 325
A+ ++ L RY + L++ + A L S AL G +VL
Sbjct: 1066 AYNKGQEFLHRYQELLDDNQAPFFLFTCAMR---WLAVRLDLISIALITTTGLMIVLMH- 1121
Query: 326 YSIGQVLTVFFSVLIG---------AFSVGQASPSIEAFANARGAAYEIFKIIDNKPS-I 375
GQ+ + + I F+V AS + F + + I + P+ I
Sbjct: 1122 ---GQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARI 1178
Query: 376 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
+ + S P +G + F N Y + +LK ++ ++ + + +VG +G GKS+
Sbjct: 1179 KNKAPSPDWPQ--EGEVTFENAEMRYRENLPL-VLKKVSFTIKPKEKIGIVGRTGSGKSS 1235
Query: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
+ RL + + G + +DG I I + LR + ++ QEPVLF+ T+ N+ +
Sbjct: 1236 LGMALFRLVELSGGCIKIDGVRISDIGLADLRSKLSIIPQEPVLFSGTVRSNLDPFNQ-Y 1294
Query: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
T D+I A++ + + I +LP K ++ V E G S G++Q + IARAL+R+ KIL+LD
Sbjct: 1295 TEDQIWDALERTHMKECIAQLPLKLESEVMENGDNFSVGERQLLCIARALLRHCKILILD 1354
Query: 556 EATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVE 608
EAT+A+DTE++ ++Q + +A T + IAHRL TV +D I G +VE
Sbjct: 1355 EATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSDRIMVLAQGQVVE 1407
>gi|157502201 ATP-binding cassette, sub-family C, member 4 isoform 1
[Homo sapiens]
Length = 1325
Score = 236 bits (602), Expect = 1e-61
Identities = 295/1309 (22%), Positives = 562/1309 (42%), Gaps = 164/1309 (12%)
Query: 22 KSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFAN 81
++E D ++ T ++ + W K Y+V+G I A + + + G++ + F N
Sbjct: 70 RAENDAQKPSLTRAIIKCY----W--KSYLVLGIFTLIEESAKV-IQPIFLGKIINYFEN 122
Query: 82 AGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAG 141
++ + N T YAY +++A + F+ +
Sbjct: 123 YDPMDSVALN--------------------TAYAYATVLTFCTLILAILHHLYFYHVQCA 162
Query: 142 RQIHKIRKQFFHAIMRQEIGWFDVH----DVGELNTRLTDDVSKINEGIGDKIGMFFQSM 197
++R H I R+ + ++ G++ L++DV+K D++ +F +
Sbjct: 163 GM--RLRVAMCHMIYRKALRLSNMAMGKTTTGQIVNLLSNDVNKF-----DQVTVFLHFL 215
Query: 198 -----------ATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLA 246
A + + G + +++L + G + ++FTD +
Sbjct: 216 WAGPLQAIAVTALLWMEIGISCLAGMAVLIILLPLQSCFGKLFSSLRSKTATFTDARI-- 273
Query: 247 YAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLI 306
EV+ IR + + +K ++ + ++ I K + ++ G
Sbjct: 274 -----RTMNEVITGIRIIKMYAWEKS----FSNLITNLRKKEISKILRSSCLRGMNLASF 324
Query: 307 Y-ASYALAFWYGTTLVLSGEYSIGQVLTVFFSV-LIGAFSVGQASPSIEAFANARGAAYE 364
+ AS + F TT VL G S+ VF +V L GA + A A
Sbjct: 325 FSASKIIVFVTFTTYVLLG--SVITASRVFVAVTLYGAVRLTVTLFFPSAIERVSEAIVS 382
Query: 365 IFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVA 424
I +I + ++ P + K + ++ + E L+GL+ V+ G+ +A
Sbjct: 383 IRRIQTFLLLDEISQRNRQLPSDGKKMVHVQDFTAFWDKASETPTLQGLSFTVRPGELLA 442
Query: 425 LVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 484
+VG G GKS+ + + P+ G+VSV G+ I VSQ+P +F+ T+
Sbjct: 443 VVGPVGAGKSSLLSAVLGELAPSHGLVSVHGR-------------IAYVSQQPWVFSGTL 489
Query: 485 AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544
NI +G++ + EK +K + L T++G+RG LSGGQK R+ +ARA
Sbjct: 490 RSNILFGKK-YEKERYEKVIKACALKKDLQLLEDGDLTVIGDRGTTLSGGQKARVNLARA 548
Query: 545 LVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDD 603
+ ++ I LLD+ SA+D E S + ++ + + + TI++ H+L ++ A I D
Sbjct: 549 VYQDADIYLLDDPLSAVDAEVSRHLFELCICQILHEKITILVTHQLQYLKAASQILILKD 608
Query: 604 GVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSND-SRSSL 662
G +V+KG + E +K GI F G+ ++ +N E + + S SS+
Sbjct: 609 GKMVQKGTYTEFLKS-GIDF--------GSLLKKDNEESEQPPVPGTPTLRNRTFSESSV 659
Query: 663 IRKRSTRRSVRG----SQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCA 718
++S+R S++ SQ + T + S V F + K +++V +F
Sbjct: 660 WSQQSSRPSLKDGALESQDTENVPVTLSEENRSEGKVGF-QAYKNYFRAGAHWIVFIFLI 718
Query: 719 IINGGLQPAFAIIF---------SKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFIT 769
++N Q A+ + ++ V T++ + N + LGI S +T
Sbjct: 719 LLNTAAQVAYVLQDWWLSYWANKQSMLNVTVNGGGNVTEKLDLNWY------LGIYSGLT 772
Query: 770 FFLQGFTFGKAGEIL--------TKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLAND 821
+ FG A +L ++ L +F S+L+ V +FD +N G + R + D
Sbjct: 773 --VATVLFGIARSLLVFYVLVNSSQTLHNKMFESILKAPVLFFD--RNPIGRILNRFSKD 828
Query: 822 AAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGV------VE 875
+ + Q + + G++ + +A++P IAI V +
Sbjct: 829 IGHLDDLLPLTFLDFIQTLLQV-VGVVS----------VAVAVIPWIAIPLVPLGIIFIF 877
Query: 876 MKMLSGQALKDKKELEGSGKIA-----TEAIENFRTVVSLTQEQKFEHMYAQSLQV---P 927
++ + +D K LE + + + +++ T+ + E++ + ++ +
Sbjct: 878 LRRYFLETSRDVKRLESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEA 937
Query: 928 YRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMA 987
+ L + F + AM A FG+ ++A L D V A+ +
Sbjct: 938 WFLFLTTSRWFAVRLDAICAMFVIIVA----FGSLILAKTL----DAGQVGLALSYALTL 989
Query: 988 VGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS----YSTEGLMPNTLEGNVTFGEVVFN 1043
+G A+ + + +IE T L Y EG + F V F
Sbjct: 990 MGMFQWCVRQSAEVENMMISVERVIEYTDLEKEAPWEYQKRPPPAWPHEGVIIFDNVNFM 1049
Query: 1044 YPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKR 1103
Y + VL+ L+ +K + + +VG +G GKS+++ L R +P GK+ +D
Sbjct: 1050 YSPGGPL-VLKHLTALIKSQEKVGIVGRTGAGKSSLISALFRLSEP-EGKIWIDKILTTE 1107
Query: 1104 LNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPN 1163
+ + LR + I+ QEP+LF ++ +N+ D + EE+ A +E + IE LP
Sbjct: 1108 IGLHDLRKKMSIIPQEPVLFTGTMRKNL---DPFNEHTDEELWNALQEVQLKETIEDLPG 1164
Query: 1164 KYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKARE 1223
K T++ + G+ S GQ+Q + +ARA++R+ IL++DEAT+ +D +++++Q+ + +
Sbjct: 1165 KMDTELAESGSNFSVGQRQLVCLARAILRKNQILIIDEATANVDPRTDELIQKKIREKFA 1224
Query: 1224 GRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQK-GIYFSMV 1271
T + IAHRL+TI ++D I+V +GR+KE+ LL K +++ MV
Sbjct: 1225 HCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLLQNKESLFYKMV 1273
>gi|134142337 ATP-binding cassette, sub-family C, member 1 isoform 1
[Homo sapiens]
Length = 1531
Score = 234 bits (598), Expect = 3e-61
Identities = 226/939 (24%), Positives = 417/939 (44%), Gaps = 86/939 (9%)
Query: 376 DSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKST 435
DS + K ++ RN F++ +R + L G+ + G VA+VG GCGKS+
Sbjct: 628 DSIERRPVKDGGGTNSITVRNATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSS 686
Query: 436 TVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENV 495
+ + D EG V++ G + V Q+ + ++ ENI +G + +
Sbjct: 687 LLSALLAEMDKVEGHVAIKGS-------------VAYVPQQAWIQNDSLRENILFGCQ-L 732
Query: 496 TMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLD 555
++ + LP T +GE+G LSGGQKQR+++ARA+ N I L D
Sbjct: 733 EEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFD 792
Query: 556 EATSALDTESEAVV---QVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNH 612
+ SA+D + + K +T I++ H +S + DVI G I E G++
Sbjct: 793 DPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSY 852
Query: 613 DELMKEKGIYFKLVTMQTAGNEVELENAADESK--------SEIDALE--MSSNDSRSSL 662
EL+ G + + + + E E A+E+ E +E M DS
Sbjct: 853 QELLARDGAFAEFLRTYAS---TEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGKQ 909
Query: 663 IRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTE---------WPYF-V 712
++++ + S ST E W++M+ + + W Y
Sbjct: 910 LQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKA 969
Query: 713 VGVFCAIINGGL---QPAFAIIFSKIIGVFTRIDDPETK--RQNSNLFSLLFLALGIISF 767
+G+F + ++ L A+ + + ++T DDP ++++ + ++ ALGI
Sbjct: 970 IGLFISFLSIFLFMCNHVSALASNYWLSLWT--DDPIVNGTQEHTKVRLSVYGALGISQG 1027
Query: 768 ITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKG 827
I F G + ++ L + S+LR +S+F+ + +G L R + + V
Sbjct: 1028 IAVFGYSMAVSIGGILASRCLHVDLLHSILRSPMSFFE--RTPSGNLVNRFSKELDTVDS 1085
Query: 828 AIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAG--VVEMKMLSGQALK 885
I + + ++ N+ I+ + T + I+P + + V + S + LK
Sbjct: 1086 MIPEVIKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVASSRQLK 1141
Query: 886 DKKELEGSGKIA--TEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFS 943
+ + S + E + + + ++++F H L+V + +KA+ I +
Sbjct: 1142 RLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQ--SDLKV---DENQKAYYPSIVAN 1196
Query: 944 FTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKI 1003
A+ C A L A LV +V + QV+++ +
Sbjct: 1197 RWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVGLSVSYSL----QVTTYLNWLVRMSS 1252
Query: 1004 SAAHIIMIIEKTPLIDSYS-TEGLMPNTLE-----------GNVTFGEVVFNYPTRPDIP 1051
I+ +E+ + YS TE P ++ G V F Y D
Sbjct: 1253 EMETNIVAVER---LKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYREDLDF- 1308
Query: 1052 VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRA 1111
VL+ +++ + G+ + +VG +G GKS++ L R + G++++DG I ++ + LR
Sbjct: 1309 VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLHDLRF 1368
Query: 1112 HLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGD 1171
+ I+ Q+P+LF S+ N+ D S EE+ + + A++ F+ +LP+K + +
Sbjct: 1369 KITIIPQDPVLFSGSLRMNL---DPFSQYSDEEVWTSLELAHLKDFVSALPDKLDHECAE 1425
Query: 1172 KGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIA 1231
G LS GQ+Q + +ARAL+R+ IL+LDEAT+A+D E++ ++Q + E T + IA
Sbjct: 1426 GGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLTIA 1485
Query: 1232 HRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSM 1270
HRL+TI + ++V G ++E+G LL Q+G+++SM
Sbjct: 1486 HRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1524
Score = 155 bits (392), Expect = 2e-37
Identities = 137/521 (26%), Positives = 246/521 (47%), Gaps = 34/521 (6%)
Query: 120 GIGAGVLVAAY-IQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDD 178
GI G+ V Y + VS + A R +H H+I+R + +F+ G L R + +
Sbjct: 1023 GISQGIAVFGYSMAVSIGGILASRCLHV---DLLHSILRSPMSFFERTPSGNLVNRFSKE 1079
Query: 179 VSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAK--IL 236
+ ++ I + I MF S+ IV T + I P LGL + +
Sbjct: 1080 LDTVDSMIPEVIKMFMGSLFNVIGACIVILL----ATPIAAIIIPPLGLIYFFVQRFYVA 1135
Query: 237 SSFTDKELLAYAKAGAVA--EEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT 294
SS K L + +++ + E L + + AF Q++ + + + ++E ++ +I
Sbjct: 1136 SSRQLKRLESVSRSPVYSHFNETLLGVSVIRAFEEQERFIHQSDLKVDENQK-AYYPSIV 1194
Query: 295 AN-------ISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQ 347
AN +G +L A +A+ + + L G L+V +S+ + +
Sbjct: 1195 ANRWLAVRLECVGNCIVLFAALFAVISRHSLSAGLVG-------LSVSYSLQVTTYLNWL 1247
Query: 348 ASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNI---KGNLEFRNVHFSYPSR 404
S E N A E K + P + G +EFRN Y
Sbjct: 1248 VRMSSEMETNI--VAVERLKEYSETEKEAPWQIQETAPPSSWPQVGRVEFRNYCLRYRED 1305
Query: 405 KEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVR 464
+ +L+ +N+ + G+ V +VG +G GKS+ + R+ + EG + +DG +I I +
Sbjct: 1306 LDF-VLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAEGEIIIDGINIAKIGLH 1364
Query: 465 FLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLV 524
LR I ++ Q+PVLF+ ++ N+ + +E+ +++ A+ DF+ LP K D
Sbjct: 1365 DLRFKITIIPQDPVLFSGSLRMNLD-PFSQYSDEEVWTSLELAHLKDFVSALPDKLDHEC 1423
Query: 525 GERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIV 584
E G LS GQ+Q + +ARAL+R KIL+LDEAT+A+D E++ ++Q + + T +
Sbjct: 1424 AEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFEDCTVLT 1483
Query: 585 IAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
IAHRL+T+ + + D G I E G +L++++G+++ +
Sbjct: 1484 IAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQRGLFYSM 1524
Score = 119 bits (298), Expect = 2e-26
Identities = 117/484 (24%), Positives = 210/484 (43%), Gaps = 59/484 (12%)
Query: 827 GAIGSRLAVITQNIANLGTGIIISFIYGWQ----LTLLLLAIVPIIAIAGVVEMKML--- 879
G I + ++V Q +L T I + + Q L LL L + P + +AGV M ++
Sbjct: 421 GEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSV-LAGVAVMVLMVPV 479
Query: 880 -SGQALKDK-------KELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNS 931
+ A+K K K + K+ E + + + E F+ Q +
Sbjct: 480 NAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAIRQEELK-V 538
Query: 932 LRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGA------ 985
L+K+ +FT F A C F Y+ + + S +F
Sbjct: 539 LKKSAYLSAVGTFTWVCTPFLVALC-TFAVYVTIDENNILDAQTAFVSLALFNILRFPLN 597
Query: 986 ---MAVGQVSSFAPDYAKAKISAAHIIM---IIEKTPLIDSYSTEGLMPNTLEGNVTFGE 1039
M + + + + +I +H + IE+ P+ D T ++T
Sbjct: 598 ILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTN---------SITVRN 648
Query: 1040 VVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGK 1099
F + R D P L G++ + +G +A+VG GCGKS+++ L D + G V + G
Sbjct: 649 ATFTW-ARSDPPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGS 707
Query: 1100 EIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIE 1159
+ V Q+ + + S+ ENI +G +++A + +E
Sbjct: 708 -------------VAYVPQQAWIQNDSLRENILFGCQLEEPYYRSVIQACA---LLPDLE 751
Query: 1160 SLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALD 1219
LP+ T++G+KG LSGGQKQR+++ARA+ I L D+ SA+D K + E +
Sbjct: 752 ILPSGDRTEIGEKGVNLSGGQKQRVSLARAVYSNADIYLFDDPLSAVDAHVGKHIFENVI 811
Query: 1220 KAR---EGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAG 1276
+ + +T I++ H +S + D+I+V G++ E G++Q+LLA+ G + + A
Sbjct: 812 GPKGMLKNKTRILVTHSMSYLPQVDVIIVMSGGKISEMGSYQELLARDGAFAEFLRTYAS 871
Query: 1277 TKRQ 1280
T+++
Sbjct: 872 TEQE 875
>gi|110832837 ATP-binding cassette, sub-family C, member 9 isoform
SUR2B [Homo sapiens]
Length = 1549
Score = 231 bits (588), Expect = 4e-60
Identities = 239/939 (25%), Positives = 428/939 (45%), Gaps = 87/939 (9%)
Query: 375 IDSYSKSGHKPDNIKGN---LEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGC 431
+DSY +S + + ++ N +FS+ S + L +++++ +GQ +VG GC
Sbjct: 652 LDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSG--LATLSNIDIRIPTGQLTMIVGQVGC 709
Query: 432 GKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLRE----IIGVVSQEPVLFATTIAEN 487
GKS+ + + EG V + + R + +Q+P L T+ EN
Sbjct: 710 GKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEEN 769
Query: 488 IRYGRENVTMDEIEKAVKEA-NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALV 546
I +G + + KAV +A + I LP T +GERG LSGGQ+QRI +ARAL
Sbjct: 770 ITFG--SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALY 827
Query: 547 RNPKILLLDEATSALDTE-SEAVVQVALDKARKG--RTTIVIAHRLSTVRNADVIAGFDD 603
+N I+ LD+ SALD S+ ++Q + K + RT +++ H+L + +AD I D
Sbjct: 828 QNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKD 887
Query: 604 GVIVEKGNHDELM-KEKGIYFKLVT-MQTAGNEVELENAADESKSEIDALEMSSNDSRSS 661
G ++ +G ++ K+ +Y T M E+E + AD++ E R +
Sbjct: 888 GSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLE-----------RKT 936
Query: 662 LIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIIN 721
L R +R + + +D + +E D+++ V R T W Y G F +I
Sbjct: 937 LRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLI- 995
Query: 722 GGLQPAFAIIFSKII--GVFTRIDD-----------PETKRQNSNLFSLLFLALGIISFI 768
+IFSK++ V ID T + + + F L
Sbjct: 996 -------LMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIF 1048
Query: 769 TFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 828
+ T G K L + + ++ + +FD G + R + D +
Sbjct: 1049 LCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQH 1106
Query: 829 IGSRLAVITQNIANLGTGIIISFI--YGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKD 886
I L +T++ T + +S I + + L+A++P+ +A K A KD
Sbjct: 1107 IPPTLESLTRS-----TLLCLSAIGMISYATPVFLVALLPL-GVAFYFIQKYFR-VASKD 1159
Query: 887 KKELEGSGKIA-----TEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGIT 941
+EL+ S ++ +E E T+ + E +F+ + L++ N++ A++F ++
Sbjct: 1160 LQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQ---RMLELTDTNNI--AYLF-LS 1213
Query: 942 FSFTQAMMYFSYAG-CFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1000
+ + Y G C A + + + + LV +++ ++ + A
Sbjct: 1214 AANRWLEVRTDYLGACIVLTASIAS--ISGSSNSGLVGLGLLYALTITNYLNWVVRNLAD 1271
Query: 1001 AKISAAHIIMIIEKTPLIDSYSTEGLM-PNTL------EGNVTFGEVVFNYPTRPDIPVL 1053
++ + + ++S + EG M P+ + EG + ++ Y PVL
Sbjct: 1272 LEVQMG-AVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK-PVL 1329
Query: 1054 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHL 1113
+ + +K GQ + + G +G GKS++ R D GK+++DG +I +L + LR+ L
Sbjct: 1330 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL 1389
Query: 1114 GIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKG 1173
I+ Q+PILF SI N+ D + + + A + A + ++SLP V + G
Sbjct: 1390 SIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1446
Query: 1174 TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHR 1233
S GQ+Q +ARA VR+ IL++DEAT+++D +E ++Q+ + A RT + IAHR
Sbjct: 1447 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1506
Query: 1234 LSTIQNADLIVVFQNGRVKEHGTHQQLLAQK-GIYFSMV 1271
+ TI ADL++V + G + E+ T + LLAQ+ G++ S V
Sbjct: 1507 VHTILTADLVIVMKRGNILEYDTPESLLAQENGVFASFV 1545
>gi|190343023 ATP-binding cassette, sub-family C, member 6 isoform 1
[Homo sapiens]
Length = 1503
Score = 228 bits (581), Expect = 3e-59
Identities = 238/911 (26%), Positives = 403/911 (44%), Gaps = 96/911 (10%)
Query: 403 SRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTIN 462
S++ L +NL V G +A+VG G GKS+ + + EG VS++G
Sbjct: 639 SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------ 692
Query: 463 VRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDT 522
+ V QE + T++ EN+ +G+E + +E+ ++ + P T
Sbjct: 693 -------VAYVPQEAWVQNTSVVENVCFGQE-LDPPWLERVLEACALQPDVDSFPEGIHT 744
Query: 523 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV---QVALDKARKG 579
+GE+G LSGGQKQR+++ARA+ R + LLD+ +ALD V + +G
Sbjct: 745 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQG 804
Query: 580 RTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELEN 639
T I++ H L + AD I +G I E G++ EL++ KG L+ +
Sbjct: 805 TTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD--------QARQ 856
Query: 640 AADESKSEIDALEMSSNDSRSSLIRKRSTRR--SVRGSQAQDRKLS---TKEALDESIPP 694
D + E + + + +S R+ RR S++ +DR S T+ LD+ P
Sbjct: 857 PGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD--PD 914
Query: 695 VSFWRIMKLNLTEWPYFVVGVFCAIINGGLQP----AFAIIFSKIIGVFTR-------ID 743
+ W K ++ ++ V A + P A + + + F R D
Sbjct: 915 RAGWPAGKDSI-QYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWAD 973
Query: 744 DPETKRQNSN------LFSLL--FLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRS 795
DP Q + +F LL A+G+ + + L G +A +L +RL + V RS
Sbjct: 974 DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGA--RASRLLFQRLLWDVVRS 1031
Query: 796 MLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW 855
+S+F+ + G L R + + V I +L + L + +S +
Sbjct: 1032 ----PISFFE--RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGL---LEVSLVVAV 1082
Query: 856 QLTLLLLAIVPIIAI-AGVVEMKMLSGQALKDKKELEGSGKIATEAIENFR--TVVSLTQ 912
L +AI+P+ + AG + ++S L+ + E + + E F+ TVV
Sbjct: 1083 ATPLATVAILPLFLLYAGFQSLYVVSSCQLR-RLESASYSSVCSHMAETFQGSTVVR--- 1138
Query: 913 EQKFEHMYAQSLQVPY--RNSLRKAHIFGITFSFTQAMMYFSY-AGCFRFGAYLVAHKLM 969
A Q P+ +N+ R I+F A + + G A
Sbjct: 1139 --------AFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCA 1190
Query: 970 SFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEK------TPLIDSY-- 1021
L V F A QV+ + + I+ +E+ TP +
Sbjct: 1191 VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRL 1250
Query: 1022 -STEGLMPNTLEGNVTFGEVVFNYPTRPDIPV-LQGLSLEVKKGQTLALVGSSGCGKSTV 1079
+ P G + F + Y RP++P+ +QG+S ++ G+ + +VG +G GKS++
Sbjct: 1251 PTCAAQPPWPQGGQIEFRDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSL 1308
Query: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
L R + G + +DG I + + LR+ + I+ Q+PILF S+ N+ D +
Sbjct: 1309 ASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQE 1365
Query: 1140 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1199
S E I A + + A + SLP + K D+G LS GQKQ + +ARAL+R+ IL+L
Sbjct: 1366 HSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILIL 1425
Query: 1200 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1259
DEAT+A+D +E +Q L T ++IAHRL ++ + ++V G+V E G+ Q
Sbjct: 1426 DEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQ 1485
Query: 1260 LLAQKGIYFSM 1270
LLAQKG+++ +
Sbjct: 1486 LLAQKGLFYRL 1496
Score = 142 bits (358), Expect = 2e-33
Identities = 126/516 (24%), Positives = 237/516 (45%), Gaps = 24/516 (4%)
Query: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
+G + + ++ L R + ++ ++R I +F+ +G L R + +
Sbjct: 994 LGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 1053
Query: 181 KINEGIGDKIGMFFQSMATFFTGFI-VGFTRGWKLTLVILAISPVLGLSAAVWAKILSSF 239
++ I DK+ +S+ + G + V L +AI P+ L A + + S
Sbjct: 1054 TVDVDIPDKL----RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 1109
Query: 240 TDKELLAYAKAGAVAE---EVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT-- 294
L A +V E V AF Q + + N ++E++RI + +
Sbjct: 1110 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR 1169
Query: 295 ---ANISI-GAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350
AN+ + G + A+ A+ + L G +S+ L V ++ +
Sbjct: 1170 WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVG-FSVSAALQVTQTLQWVVRNWTDLEN 1228
Query: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKI- 409
SI + + A+ + P+ + P G +EFR+ Y R E+ +
Sbjct: 1229 SIVSVERMQDYAWTPKEAPWRLPTC-----AAQPPWPQGGQIEFRDFGLRY--RPELPLA 1281
Query: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
++G++ K+ +G+ V +VG +G GKS+ + RL + EG + +DG I + + LR
Sbjct: 1282 VQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSR 1341
Query: 470 IGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGA 529
I ++ Q+P+LF ++ N+ +E+ + + I A++ + LP + +RG
Sbjct: 1342 ISIIPQDPILFPGSLRMNLDLLQEH-SDEAIWAALETVQLKALVASLPGQLQYKCADRGE 1400
Query: 530 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRL 589
LS GQKQ + +ARAL+R +IL+LDEAT+A+D +E +Q L T ++IAHRL
Sbjct: 1401 DLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRL 1460
Query: 590 STVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
+V + + D G + E G+ +L+ +KG++++L
Sbjct: 1461 RSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1496
>gi|239756495 PREDICTED: hypothetical protein [Homo sapiens]
Length = 1312
Score = 228 bits (581), Expect = 3e-59
Identities = 238/911 (26%), Positives = 403/911 (44%), Gaps = 96/911 (10%)
Query: 403 SRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTIN 462
S++ L +NL V G +A+VG G GKS+ + + EG VS++G
Sbjct: 448 SQESPPCLHRINLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGA------ 501
Query: 463 VRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDT 522
+ V QE + T++ EN+ +G+E + +E+ ++ + P T
Sbjct: 502 -------VAYVPQEAWVQNTSVVENVCFGQE-LDPPWLERVLEACALQPDVDSFPEGIHT 553
Query: 523 LVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV---QVALDKARKG 579
+GE+G LSGGQKQR+++ARA+ R + LLD+ +ALD V + +G
Sbjct: 554 SIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDDPLAALDAHVGQHVFNQVIGPGGLLQG 613
Query: 580 RTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELEN 639
T I++ H L + AD I +G I E G++ EL++ KG L+ +
Sbjct: 614 TTRILVTHALHILPQADWIIVLANGAIAEMGSYQELLQRKGALVCLLD--------QARQ 665
Query: 640 AADESKSEIDALEMSSNDSRSSLIRKRSTRR--SVRGSQAQDRKLS---TKEALDESIPP 694
D + E + + + +S R+ RR S++ +DR S T+ LD+ P
Sbjct: 666 PGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQTEVPLDD--PD 723
Query: 695 VSFWRIMKLNLTEWPYFVVGVFCAIINGGLQP----AFAIIFSKIIGVFTR-------ID 743
+ W K ++ ++ V A + P A + + + F R D
Sbjct: 724 RAGWPAGKDSI-QYGRVKATVHLAYLRAVGTPLCLYALFLFLCQQVASFCRGYWLSLWAD 782
Query: 744 DPETKRQNSN------LFSLL--FLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRS 795
DP Q + +F LL A+G+ + + L G +A +L +RL + V RS
Sbjct: 783 DPAVGGQQTQAALRGGIFGLLGCLQAIGLFASMAAVLLGGA--RASRLLFQRLLWDVVRS 840
Query: 796 MLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW 855
+S+F+ + G L R + + V I +L + L + +S +
Sbjct: 841 ----PISFFE--RTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGL---LEVSLVVAV 891
Query: 856 QLTLLLLAIVPIIAI-AGVVEMKMLSGQALKDKKELEGSGKIATEAIENFR--TVVSLTQ 912
L +AI+P+ + AG + ++S L+ + E + + E F+ TVV
Sbjct: 892 ATPLATVAILPLFLLYAGFQSLYVVSSCQLR-RLESASYSSVCSHMAETFQGSTVVR--- 947
Query: 913 EQKFEHMYAQSLQVPY--RNSLRKAHIFGITFSFTQAMMYFSY-AGCFRFGAYLVAHKLM 969
A Q P+ +N+ R I+F A + + G A
Sbjct: 948 --------AFRTQAPFVAQNNARVDESQRISFPRLVADRWLAANVELLGNGLVFAAATCA 999
Query: 970 SFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEK------TPLIDSY-- 1021
L V F A QV+ + + I+ +E+ TP +
Sbjct: 1000 VLSKAHLSAGLVGFSVSAALQVTQTLQWVVRNWTDLENSIVSVERMQDYAWTPKEAPWRL 1059
Query: 1022 -STEGLMPNTLEGNVTFGEVVFNYPTRPDIPV-LQGLSLEVKKGQTLALVGSSGCGKSTV 1079
+ P G + F + Y RP++P+ +QG+S ++ G+ + +VG +G GKS++
Sbjct: 1060 PTCAAQPPWPQGGQIEFQDFGLRY--RPELPLAVQGVSFKIHAGEKVGIVGRTGAGKSSL 1117
Query: 1080 VQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRV 1139
L R + G + +DG I + + LR+ + I+ Q+PILF S+ N+ D +
Sbjct: 1118 ASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISIIPQDPILFPGSLRMNL---DLLQE 1174
Query: 1140 VSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLL 1199
S E I A + + A + SLP + K D+G LS GQKQ + +ARAL+R+ IL+L
Sbjct: 1175 HSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLLCLARALLRKTQILIL 1234
Query: 1200 DEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQ 1259
DEAT+A+D +E +Q L T ++IAHRL ++ + ++V G+V E G+ Q
Sbjct: 1235 DEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKGQVAESGSPAQ 1294
Query: 1260 LLAQKGIYFSM 1270
LLAQKG+++ +
Sbjct: 1295 LLAQKGLFYRL 1305
Score = 140 bits (354), Expect = 6e-33
Identities = 125/516 (24%), Positives = 237/516 (45%), Gaps = 24/516 (4%)
Query: 121 IGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVS 180
+G + + ++ L R + ++ ++R I +F+ +G L R + +
Sbjct: 803 LGCLQAIGLFASMAAVLLGGARASRLLFQRLLWDVVRSPISFFERTPIGHLLNRFSKETD 862
Query: 181 KINEGIGDKIGMFFQSMATFFTGFI-VGFTRGWKLTLVILAISPVLGLSAAVWAKILSSF 239
++ I DK+ +S+ + G + V L +AI P+ L A + + S
Sbjct: 863 TVDVDIPDKL----RSLLMYAFGLLEVSLVVAVATPLATVAILPLFLLYAGFQSLYVVSS 918
Query: 240 TDKELLAYAKAGAVAE---EVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT-- 294
L A +V E V AF Q + + N ++E++RI + +
Sbjct: 919 CQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQNNARVDESQRISFPRLVADR 978
Query: 295 ---ANISI-GAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASP 350
AN+ + G + A+ A+ + L G +S+ L V ++ +
Sbjct: 979 WLAANVELLGNGLVFAAATCAVLSKAHLSAGLVG-FSVSAALQVTQTLQWVVRNWTDLEN 1037
Query: 351 SIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKI- 409
SI + + A+ + P+ + P G +EF++ Y R E+ +
Sbjct: 1038 SIVSVERMQDYAWTPKEAPWRLPTC-----AAQPPWPQGGQIEFQDFGLRY--RPELPLA 1090
Query: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
++G++ K+ +G+ V +VG +G GKS+ + RL + EG + +DG I + + LR
Sbjct: 1091 VQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSR 1150
Query: 470 IGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGA 529
I ++ Q+P+LF ++ N+ +E+ + + I A++ + LP + +RG
Sbjct: 1151 ISIIPQDPILFPGSLRMNLDLLQEH-SDEAIWAALETVQLKALVASLPGQLQYKCADRGE 1209
Query: 530 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRL 589
LS GQKQ + +ARAL+R +IL+LDEAT+A+D +E +Q L T ++IAHRL
Sbjct: 1210 DLSVGQKQLLCLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRL 1269
Query: 590 STVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKL 625
+V + + D G + E G+ +L+ +KG++++L
Sbjct: 1270 RSVMDCARVLVMDKGQVAESGSPAQLLAQKGLFYRL 1305
>gi|73747917 transporter 2, ATP-binding cassette, sub-family B
isoform 2 [Homo sapiens]
Length = 653
Score = 226 bits (576), Expect = 1e-58
Identities = 141/428 (32%), Positives = 242/428 (56%), Gaps = 16/428 (3%)
Query: 146 KIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATF--FTG 203
+IR+Q F +++RQ++G+F GELN+RL+ D + ++ + + +S+ G
Sbjct: 224 RIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYG 283
Query: 204 FIVGFTRGWKLTLVILAISPVLGLSAAVW----AKILSSFTDKELLAYAKAGAVAEEVLA 259
F++ + +LTL+ L P + V+ ++L D A A+AG V E +
Sbjct: 284 FMLSISP--RLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQD----AVARAGQVVREAVG 337
Query: 260 AIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTT 319
++TV +FG ++ E+ RY + LE+ +++ ++ + + + +L L G
Sbjct: 338 GLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQ 397
Query: 320 LVLSGEYSIGQVLT-VFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSY 378
+ GE + G +L+ + + +G++ + +N GAA ++F +D +P++ S
Sbjct: 398 QMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNV-GAAEKVFSYMDRQPNLPSP 456
Query: 379 SKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQ 438
P ++G ++F++V F+YP+R + +LKGL ++ G+ ALVG +G GKST
Sbjct: 457 GTLA--PTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAA 514
Query: 439 LMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMD 498
L+Q LY PT G V +D + I +L + V QEPVLF+ ++ NI YG ++ D
Sbjct: 515 LLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDD 574
Query: 499 EIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEAT 558
++ A + A+A DFI ++ H T VGE+G+QL+ GQKQR+AIARALVR+P++L+LDEAT
Sbjct: 575 KVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEAT 634
Query: 559 SALDTESE 566
SALD + E
Sbjct: 635 SALDVQCE 642
Score = 209 bits (533), Expect = 1e-53
Identities = 163/540 (30%), Positives = 264/540 (48%), Gaps = 54/540 (10%)
Query: 695 VSFWRIMKLNLTEWPYFVVGVF---CAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQN 751
V WR++KL+ + P V F A++ L P ++ ++I + DP
Sbjct: 136 VLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYS---GRVIDILGGDFDPHAFA-- 190
Query: 752 SNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTT 811
S +F + + G S ++ +G F + R+R +F S+LRQD+ +F + K T
Sbjct: 191 SAIFFMCLFSFG--SSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETK--T 246
Query: 812 GALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGW------QLTLLLLAIV 865
G L +RL++D + + V+ +++ + +YG+ +LTLL L +
Sbjct: 247 GELNSRLSSDTTLMSNWLPLNANVLLRSLVK------VVGLYGFMLSISPRLTLLSLLHM 300
Query: 866 PIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQ----KFEHMYA 921
P A V + + + +G++ EA+ +TV S E+ +++
Sbjct: 301 PFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALE 360
Query: 922 QSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK--LMSFEDVLLVFS 979
Q Q+ +R L +A +Y G ++ L +D L
Sbjct: 361 QCRQLYWRRDLERA-------------LYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQG 407
Query: 980 AVVFGAMAVGQVSSFAP-------DYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLE 1032
+++ + V S+ D +A + +++ P + S T L P TL+
Sbjct: 408 SLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGT--LAPTTLQ 465
Query: 1033 GNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAG 1092
G V F +V F YP RPD PVL+GL+ ++ G+ ALVG +G GKSTV LL+ Y P G
Sbjct: 466 GVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGG 525
Query: 1093 KVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA 1152
+VLLD K I + +L + + V QEP+LF S+ NIAYG S ++++ AA+ A
Sbjct: 526 QVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQS--CEDDKVMAAAQAA 583
Query: 1153 NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1212
+ FI+ + + T VG+KG+QL+ GQKQR+AIARALVR P +L+LDEATSALD + E+
Sbjct: 584 HADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQ 643
>gi|110832835 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A [Homo sapiens]
Length = 1549
Score = 224 bits (572), Expect = 3e-58
Identities = 238/936 (25%), Positives = 423/936 (45%), Gaps = 86/936 (9%)
Query: 375 IDSYSKSGHKPDNIKGN---LEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGC 431
+DSY +S + + ++ N +FS+ S + L +++++ +GQ +VG GC
Sbjct: 652 LDSYEQSTRRLRPAETEDIAIKVTNGYFSWGSG--LATLSNIDIRIPTGQLTMIVGQVGC 709
Query: 432 GKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLRE----IIGVVSQEPVLFATTIAEN 487
GKS+ + + EG V + + R + +Q+P L T+ EN
Sbjct: 710 GKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEEN 769
Query: 488 IRYGRENVTMDEIEKAVKEA-NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALV 546
I +G + + KAV +A + I LP T +GERG LSGGQ+QRI +ARAL
Sbjct: 770 ITFG--SPFNKQRYKAVTDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALY 827
Query: 547 RNPKILLLDEATSALDTE-SEAVVQVALDKARKG--RTTIVIAHRLSTVRNADVIAGFDD 603
+N I+ LD+ SALD S+ ++Q + K + RT +++ H+L + +AD I D
Sbjct: 828 QNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKD 887
Query: 604 GVIVEKGNHDELM-KEKGIYFKLVT-MQTAGNEVELENAADESKSEIDALEMSSNDSRSS 661
G ++ +G ++ K+ +Y T M E+E + AD++ E R +
Sbjct: 888 GSVLREGTLKDIQTKDVELYEHWKTLMNRQDQELEKDMEADQTTLE-----------RKT 936
Query: 662 LIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIIN 721
L R +R + + +D + +E D+++ V R T W Y G F +I
Sbjct: 937 LRRAMYSREAKAQMEDEDEEEEEEEDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLI- 995
Query: 722 GGLQPAFAIIFSKII--GVFTRIDD-----------PETKRQNSNLFSLLFLALGIISFI 768
+IFSK++ V ID T + + + F L
Sbjct: 996 -------LMIFSKLLKHSVIVAIDYWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIF 1048
Query: 769 TFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGA 828
+ T G K L + + ++ + +FD G + R + D +
Sbjct: 1049 LCLVTSLTVEWMGLTAAKNLHHNLLNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQH 1106
Query: 829 IGSRLAVITQNIANLGTGIIISFI--YGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKD 886
I L +T++ T + +S I + + L+A++P+ +A K A KD
Sbjct: 1107 IPPTLESLTRS-----TLLCLSAIGMISYATPVFLVALLPL-GVAFYFIQKYFR-VASKD 1159
Query: 887 KKELEGSGKIA-----TEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGIT 941
+EL+ S ++ +E E T+ + E +F+ + L++ N++ A++F ++
Sbjct: 1160 LQELDDSTQLPLLCHFSETAEGLTTIRAFRHETRFKQ---RMLELTDTNNI--AYLF-LS 1213
Query: 942 FSFTQAMMYFSYAG-CFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAK 1000
+ + Y G C A + + + + LV +++ ++ + A
Sbjct: 1214 AANRWLEVRTDYLGACIVLTASIAS--ISGSSNSGLVGLGLLYALTITNYLNWVVRNLAD 1271
Query: 1001 AKISAAHIIMIIEKTPLIDSYSTEGLM-PNTL------EGNVTFGEVVFNYPTRPDIPVL 1053
++ + + ++S + EG M P+ + EG + ++ Y PVL
Sbjct: 1272 LEVQMG-AVKKVNSFLTMESENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK-PVL 1329
Query: 1054 QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHL 1113
+ + +K GQ + + G +G GKS++ R D GK+++DG +I +L + LR+ L
Sbjct: 1330 KHVKAYIKPGQKVGICGRTGSGKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRL 1389
Query: 1114 GIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKG 1173
I+ Q+PILF SI N+ D + + + A + A + ++SLP V + G
Sbjct: 1390 SIILQDPILFSGSIRFNL---DPECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGG 1446
Query: 1174 TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHR 1233
S GQ+Q +ARA VR+ IL++DEAT+++D +E ++Q+ + A RT + IAHR
Sbjct: 1447 ENFSVGQRQLFCLARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHR 1506
Query: 1234 LSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFS 1269
+S+I +A L++VF G + E T LLA K FS
Sbjct: 1507 VSSIMDAGLVLVFSEGILVECDTVPNLLAHKNGLFS 1542
Score = 127 bits (320), Expect = 5e-29
Identities = 77/257 (29%), Positives = 133/257 (51%), Gaps = 15/257 (5%)
Query: 386 DNIKGNLEFRNVHFSYPSRKEVKI--------------LKGLNLKVQSGQTVALVGNSGC 431
+N +G ++ V +P E+KI LK + ++ GQ V + G +G
Sbjct: 1291 ENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGS 1350
Query: 432 GKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYG 491
GKS+ R+ D +G + +DG DI + + LR + ++ Q+P+LF+ +I N+
Sbjct: 1351 GKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-P 1409
Query: 492 RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKI 551
T D + +A++ A + + LP D +V E G S GQ+Q +ARA VR I
Sbjct: 1410 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1469
Query: 552 LLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGN 611
L++DEAT+++D +E ++Q + A RT + IAHR+S++ +A ++ F +G++VE
Sbjct: 1470 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1529
Query: 612 HDELMKEKGIYFKLVTM 628
L+ K F + M
Sbjct: 1530 VPNLLAHKNGLFSTLVM 1546
>gi|110832839 ATP-binding cassette, sub-family C, member 9 isoform
SUR2A-delta-14 [Homo sapiens]
Length = 1513
Score = 224 bits (570), Expect = 5e-58
Identities = 234/912 (25%), Positives = 413/912 (45%), Gaps = 83/912 (9%)
Query: 396 NVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDG 455
N +FS+ S + L +++++ +GQ +VG GCGKS+ + + EG V
Sbjct: 640 NGYFSWGSG--LATLSNIDIRIPTGQLTMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSN 697
Query: 456 QDIRTINVRFLRE----IIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEA-NAY 510
+ + R + +Q+P L T+ ENI +G + + KAV +A +
Sbjct: 698 VNESEPSFEATRSRNRYSVAYAAQKPWLLNATVEENITFG--SPFNKQRYKAVTDACSLQ 755
Query: 511 DFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SEAVV 569
I LP T +GERG LSGGQ+QRI +ARAL +N I+ LD+ SALD S+ ++
Sbjct: 756 PDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDDPFSALDIHLSDHLM 815
Query: 570 QVALDKARKG--RTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELM-KEKGIYFKLV 626
Q + K + RT +++ H+L + +AD I DG ++ +G ++ K+ +Y
Sbjct: 816 QEGILKFLQDDKRTLVLVTHKLQYLTHADWIIAMKDGSVLREGTLKDIQTKDVELYEHWK 875
Query: 627 T-MQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTK 685
T M E+E + AD++ E R +L R +R + + +D + +
Sbjct: 876 TLMNRQDQELEKDMEADQTTLE-----------RKTLRRAMYSREAKAQMEDEDEEEEEE 924
Query: 686 EALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKII--GVFTRID 743
E D+++ V R T W Y G F +I +IFSK++ V ID
Sbjct: 925 EDEDDNMSTVMRLRTKMPWKTCWRYLTSGGFFLLI--------LMIFSKLLKHSVIVAID 976
Query: 744 D-----------PETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMV 792
T + + + F L + T G K L + +
Sbjct: 977 YWLATWTSEYSINNTGKADQTYYVAGFSILCGAGIFLCLVTSLTVEWMGLTAAKNLHHNL 1036
Query: 793 FRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFI 852
++ + +FD G + R + D + I L +T++ T + +S I
Sbjct: 1037 LNKIILGPIRFFDT--TPLGLILNRFSADTNIIDQHIPPTLESLTRS-----TLLCLSAI 1089
Query: 853 --YGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA-----TEAIENFR 905
+ + L+A++P+ +A K A KD +EL+ S ++ +E E
Sbjct: 1090 GMISYATPVFLVALLPL-GVAFYFIQKYFR-VASKDLQELDDSTQLPLLCHFSETAEGLT 1147
Query: 906 TVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAG-CFRFGAYLV 964
T+ + E +F+ + L++ N++ A++F ++ + + Y G C A +
Sbjct: 1148 TIRAFRHETRFKQ---RMLELTDTNNI--AYLF-LSAANRWLEVRTDYLGACIVLTASIA 1201
Query: 965 AHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTE 1024
+ + + LV +++ ++ + A ++ + + ++S + E
Sbjct: 1202 S--ISGSSNSGLVGLGLLYALTITNYLNWVVRNLADLEVQMG-AVKKVNSFLTMESENYE 1258
Query: 1025 GLM-PNTL------EGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKS 1077
G M P+ + EG + ++ Y PVL+ + +K GQ + + G +G GKS
Sbjct: 1259 GTMDPSQVPEHWPQEGEIKIHDLCVRYENNLK-PVLKHVKAYIKPGQKVGICGRTGSGKS 1317
Query: 1078 TVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNS 1137
++ R D GK+++DG +I +L + LR+ L I+ Q+PILF SI N+ D
Sbjct: 1318 SLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNL---DPE 1374
Query: 1138 RVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHIL 1197
+ + + A + A + ++SLP V + G S GQ+Q +ARA VR+ IL
Sbjct: 1375 CKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSIL 1434
Query: 1198 LLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTH 1257
++DEAT+++D +E ++Q+ + A RT + IAHR+S+I +A L++VF G + E T
Sbjct: 1435 IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDTV 1494
Query: 1258 QQLLAQKGIYFS 1269
LLA K FS
Sbjct: 1495 PNLLAHKNGLFS 1506
Score = 127 bits (320), Expect = 5e-29
Identities = 77/257 (29%), Positives = 133/257 (51%), Gaps = 15/257 (5%)
Query: 386 DNIKGNLEFRNVHFSYPSRKEVKI--------------LKGLNLKVQSGQTVALVGNSGC 431
+N +G ++ V +P E+KI LK + ++ GQ V + G +G
Sbjct: 1255 ENYEGTMDPSQVPEHWPQEGEIKIHDLCVRYENNLKPVLKHVKAYIKPGQKVGICGRTGS 1314
Query: 432 GKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYG 491
GKS+ R+ D +G + +DG DI + + LR + ++ Q+P+LF+ +I N+
Sbjct: 1315 GKSSLSLAFFRMVDIFDGKIVIDGIDISKLPLHTLRSRLSIILQDPILFSGSIRFNLD-P 1373
Query: 492 RENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKI 551
T D + +A++ A + + LP D +V E G S GQ+Q +ARA VR I
Sbjct: 1374 ECKCTDDRLWEALEIAQLKNMVKSLPGGLDAVVTEGGENFSVGQRQLFCLARAFVRKSSI 1433
Query: 552 LLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGN 611
L++DEAT+++D +E ++Q + A RT + IAHR+S++ +A ++ F +G++VE
Sbjct: 1434 LIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVSSIMDAGLVLVFSEGILVECDT 1493
Query: 612 HDELMKEKGIYFKLVTM 628
L+ K F + M
Sbjct: 1494 VPNLLAHKNGLFSTLVM 1510
Score = 104 bits (260), Expect = 5e-22
Identities = 130/558 (23%), Positives = 233/558 (41%), Gaps = 52/558 (9%)
Query: 735 IIGVFTRIDDPETKRQNSN-----LFSLLFL----ALGIISFITFFLQGFTFGKAGEILT 785
I G+ R+++ + N+ L S FL L ++ F+ LQ TF +A +T
Sbjct: 318 ISGIVQRVNETQNGTNNTTGISETLSSKEFLENAYVLAVLLFLALILQR-TFLQASYYVT 376
Query: 786 KR--------LRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVIT 837
L M++ +LR S + T G + +A + Q+ + +
Sbjct: 377 IETGINLRGALLAMIYNKILRLSTSNLSMGEMTLGQINNLVAIETNQLMWFL-----FLC 431
Query: 838 QNIANLGTGIIISFIYGWQLT-LLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKI 896
N+ + II+ I + L L +I + ++ + + A K L+ S
Sbjct: 432 PNLWAMPVQIIMGVILLYNLLGSSALVGAAVIVLLAPIQYFIATKLAEAQKSTLDYS--- 488
Query: 897 ATEAIENFRTV---VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFT----QAMM 949
TE ++ + + L + +EH++ +S++ L F + S + A+
Sbjct: 489 -TERLKKTNEILKGIKLLKLYAWEHIFCKSVEETRMKELSSLKTFALYTSLSIFMNAAIP 547
Query: 950 YFSYAGCFRFGAYLVAHKLMSFEDV--LLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAH 1007
+ F AY + L E L +F +V + V FA KA IS
Sbjct: 548 IAAVLATFVTHAYASGNNLKPAEAFASLSLFHILVTPLFLLSTVVRFA---VKAIISVQK 604
Query: 1008 IIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFN--YPTRPDIPVLQGLSLEVKKGQT 1065
+ + + D G E VV N + + L + + + GQ
Sbjct: 605 LNEFLLSDEIGDDSWRTGESSLPFESCKKHTGVVTNGYFSWGSGLATLSNIDIRIPTGQL 664
Query: 1066 LALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAH----LGIVSQEPI 1121
+VG GCGKS+++ + L GKV + + R+ + +Q+P
Sbjct: 665 TMIVGQVGCGKSSLLLAILGEMQTLEGKVHWSNVNESEPSFEATRSRNRYSVAYAAQKPW 724
Query: 1122 LFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQK 1181
L + ++ ENI +G + + A ++ I+ LP T++G++G LSGGQ+
Sbjct: 725 LLNATVEENITFGSPFNKQRYKAVTDAC---SLQPDIDLLPFGDQTEIGERGINLSGGQR 781
Query: 1182 QRIAIARALVRQPHILLLDEATSALDTE-SEKVVQEALDK--AREGRTCIVIAHRLSTIQ 1238
QRI +ARAL + +I+ LD+ SALD S+ ++QE + K + RT +++ H+L +
Sbjct: 782 QRICVARALYQNTNIVFLDDPFSALDIHLSDHLMQEGILKFLQDDKRTLVLVTHKLQYLT 841
Query: 1239 NADLIVVFQNGRVKEHGT 1256
+AD I+ ++G V GT
Sbjct: 842 HADWIIAMKDGSVLREGT 859
>gi|21729873 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 219 bits (557), Expect = 2e-56
Identities = 282/1212 (23%), Positives = 507/1212 (41%), Gaps = 197/1212 (16%)
Query: 169 GELNTRLTDDVSKINEGI--GDKIGMFFQSMA--TFFTGFIVGFTRGWKLTLVILAISPV 224
GE + T DV+ + EG+ G + + S+ + + FI+G+T + L L + P+
Sbjct: 258 GEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT-AFIAILCYLLVFPL 316
Query: 225 LGLSAAVWAKI---LSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQK------KELE 275
+ K S +D+ + V EVL I+ + + +K ++L
Sbjct: 317 AVFMTRMAVKAQHHTSEVSDQRI-------RVTSEVLTCIKLIKMYTWEKPFAKIIEDLR 369
Query: 276 RYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVF 335
R + L E + G+ +++T+ L I + A A W L + + ++
Sbjct: 370 RKERKLLE--KCGLVQSLTS------ITLFIIPTVATAVWVLIHTSLKLKLTASMAFSML 421
Query: 336 FSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI-----------------DSY 378
S+ + SV +++ N++ A K + + +
Sbjct: 422 ASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATL 481
Query: 379 SKSGHKPDNIKGNLEF-RNVHFSY----------PSRKEVKI---LKGLNLKVQSGQTVA 424
S P + G LE RN H S P + + L +NL V G +
Sbjct: 482 SWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLG 541
Query: 425 LVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 484
+ GN+G GKS+ + + EG V V G + V Q+ + + I
Sbjct: 542 VCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS-------------LAYVPQQAWIVSGNI 588
Query: 485 AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544
ENI G ++ + + + LP T +GERG LSGGQKQRI++ARA
Sbjct: 589 RENILMGGAYDKARYLQ-VLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARA 647
Query: 545 LVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDD 603
+ + +I LLD+ SA+D + + + + K +G+T +++ H+L + I ++
Sbjct: 648 VYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLEN 707
Query: 604 GVIVEKGNHDELMKEKGIYFKLVTM--QTAGNEVELENAADESKSEIDALEMSSNDSRSS 661
G I E G H ELM++KG Y +L+ + A +++ + A K ++++ +++
Sbjct: 708 GKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALAT------ 761
Query: 662 LIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIIN 721
S S+ G+ + +L+ +E ++E WR+ + ++V C I
Sbjct: 762 -----SLEESLNGNAVPEHQLTQEEEMEEGSLS---WRVYHHYIQAAGGYMVS--CIIFF 811
Query: 722 GGLQPAFAIIFS----------------------KIIGVFTRIDDPETKRQNS--NLFSL 757
+ F IFS + + D+P+ L +L
Sbjct: 812 FVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNAL 871
Query: 758 LFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTR 817
L + +G+ S F K + L +F + R +S+FD G L
Sbjct: 872 LLICVGVCS-------SGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIP--IGRLLNC 922
Query: 818 LANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMK 877
A D Q + L + ++ L +I + L++ + P I + G + M
Sbjct: 923 FAGDLEQ----LDQLLPIFSEQFLVLSLMVIA-------VLLIVSVLSPYILLMGAIIMV 971
Query: 878 MLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHI 937
+ + KK AI F+ + + ++ F H+ SLQ L H+
Sbjct: 972 ICFIYYMMFKK-----------AIGVFKRLENYSRSPLFSHIL-NSLQ-----GLSSIHV 1014
Query: 938 FGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFE-------DVLLVFSAVVFG------ 984
+G T F + A +L + + M+ L V V FG
Sbjct: 1015 YGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPY 1074
Query: 985 ---AMAVGQVSSFAPDY---------AKAKISAAHII-----MIIEKTPLIDSYSTEGLM 1027
MAV V A + +A+ +A I M + + PL EG
Sbjct: 1075 SFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPL----HMEGT- 1129
Query: 1028 PNTLEGNVTFGEVVF---NYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 1083
+ +G GE++F + R + P VL G++L ++ + + +VG +G GKS++ L
Sbjct: 1130 -SCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMAL 1188
Query: 1084 ERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQE 1143
R +P+AG++L+DG +I + ++ LR+ L ++ Q+P+L +I N+ D + +
Sbjct: 1189 FRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH---TDQ 1245
Query: 1144 EIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEAT 1203
+I A + + I P K T V + G S G++Q + IARA++R I+L+DEAT
Sbjct: 1246 QIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEAT 1305
Query: 1204 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1263
+++D E++ ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L +
Sbjct: 1306 ASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKK 1365
Query: 1264 KGIYFSMVSVQA 1275
G F+ + A
Sbjct: 1366 PGSLFAALMATA 1377
>gi|15149474 ATP-binding cassette, sub-family C, member 11 isoform a
[Homo sapiens]
Length = 1382
Score = 219 bits (557), Expect = 2e-56
Identities = 282/1212 (23%), Positives = 507/1212 (41%), Gaps = 197/1212 (16%)
Query: 169 GELNTRLTDDVSKINEGI--GDKIGMFFQSMA--TFFTGFIVGFTRGWKLTLVILAISPV 224
GE + T DV+ + EG+ G + + S+ + + FI+G+T + L L + P+
Sbjct: 258 GEAISFFTGDVNYLFEGVCYGPLVLITCASLVICSISSYFIIGYT-AFIAILCYLLVFPL 316
Query: 225 LGLSAAVWAKI---LSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQK------KELE 275
+ K S +D+ + V EVL I+ + + +K ++L
Sbjct: 317 AVFMTRMAVKAQHHTSEVSDQRI-------RVTSEVLTCIKLIKMYTWEKPFAKIIEDLR 369
Query: 276 RYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVF 335
R + L E + G+ +++T+ L I + A A W L + + ++
Sbjct: 370 RKERKLLE--KCGLVQSLTS------ITLFIIPTVATAVWVLIHTSLKLKLTASMAFSML 421
Query: 336 FSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSI-----------------DSY 378
S+ + SV +++ N++ A K + + +
Sbjct: 422 ASLNLLRLSVFFVPIAVKGLTNSKSAVMRFKKFFLQESPVFYVQTLQDPSKALVFEEATL 481
Query: 379 SKSGHKPDNIKGNLEF-RNVHFSY----------PSRKEVKI---LKGLNLKVQSGQTVA 424
S P + G LE RN H S P + + L +NL V G +
Sbjct: 482 SWQQTCPGIVNGALELERNGHASEGMTRPRDALGPEEEGNSLGPELHKINLVVSKGMMLG 541
Query: 425 LVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 484
+ GN+G GKS+ + + EG V V G + V Q+ + + I
Sbjct: 542 VCGNTGSGKSSLLSAILEEMHLLEGSVGVQGS-------------LAYVPQQAWIVSGNI 588
Query: 485 AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARA 544
ENI G ++ + + + LP T +GERG LSGGQKQRI++ARA
Sbjct: 589 RENILMGGAYDKARYLQ-VLHCCSLNRDLELLPFGDMTEIGERGLNLSGGQKQRISLARA 647
Query: 545 LVRNPKILLLDEATSALDTE-SEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDD 603
+ + +I LLD+ SA+D + + + + K +G+T +++ H+L + I ++
Sbjct: 648 VYSDRQIYLLDDPLSAVDAHVGKHIFEECIKKTLRGKTVVLVTHQLQYLEFCGQIILLEN 707
Query: 604 GVIVEKGNHDELMKEKGIYFKLVTM--QTAGNEVELENAADESKSEIDALEMSSNDSRSS 661
G I E G H ELM++KG Y +L+ + A +++ + A K ++++ +++
Sbjct: 708 GKICENGTHSELMQKKGKYAQLIQKMHKEATSDMLQDTAKIAEKPKVESQALAT------ 761
Query: 662 LIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIIN 721
S S+ G+ + +L+ +E ++E WR+ + ++V C I
Sbjct: 762 -----SLEESLNGNAVPEHQLTQEEEMEEGSLS---WRVYHHYIQAAGGYMVS--CIIFF 811
Query: 722 GGLQPAFAIIFS----------------------KIIGVFTRIDDPETKRQNS--NLFSL 757
+ F IFS + + D+P+ L +L
Sbjct: 812 FVVLIVFLTIFSFWWLSYWLEQGSGTNSSRESNGTMADLGNIADNPQLSFYQLVYGLNAL 871
Query: 758 LFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTR 817
L + +G+ S F K + L +F + R +S+FD G L
Sbjct: 872 LLICVGVCS-------SGIFTKVTRKASTALHNKLFNKVFRCPMSFFDTIP--IGRLLNC 922
Query: 818 LANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMK 877
A D Q + L + ++ L +I + L++ + P I + G + M
Sbjct: 923 FAGDLEQ----LDQLLPIFSEQFLVLSLMVIA-------VLLIVSVLSPYILLMGAIIMV 971
Query: 878 MLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHI 937
+ + KK AI F+ + + ++ F H+ SLQ L H+
Sbjct: 972 ICFIYYMMFKK-----------AIGVFKRLENYSRSPLFSHIL-NSLQ-----GLSSIHV 1014
Query: 938 FGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFE-------DVLLVFSAVVFG------ 984
+G T F + A +L + + M+ L V V FG
Sbjct: 1015 YGKTEDFISQFKRLTDAQNNYLLLFLSSTRWMALRLEIMTNLVTLAVALFVAFGISSTPY 1074
Query: 985 ---AMAVGQVSSFAPDY---------AKAKISAAHII-----MIIEKTPLIDSYSTEGLM 1027
MAV V A + +A+ +A I M + + PL EG
Sbjct: 1075 SFKVMAVNIVLQLASSFQATARIGLETEAQFTAVERILQYMKMCVSEAPL----HMEGT- 1129
Query: 1028 PNTLEGNVTFGEVVF---NYPTRPDIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLL 1083
+ +G GE++F + R + P VL G++L ++ + + +VG +G GKS++ L
Sbjct: 1130 -SCPQGWPQHGEIIFQDYHMKYRDNTPTVLHGINLTIRGHEVVGIVGRTGSGKSSLGMAL 1188
Query: 1084 ERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQE 1143
R +P+AG++L+DG +I + ++ LR+ L ++ Q+P+L +I N+ D + +
Sbjct: 1189 FRLVEPMAGRILIDGVDICSIGLEDLRSKLSVIPQDPVLLSGTIRFNLDPFDRH---TDQ 1245
Query: 1144 EIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEAT 1203
+I A + + I P K T V + G S G++Q + IARA++R I+L+DEAT
Sbjct: 1246 QIWDALERTFLTKAISKFPKKLHTDVVENGGNFSVGERQLLCIARAVLRNSKIILIDEAT 1305
Query: 1204 SALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1263
+++D E++ ++Q + +A +G T +VIAHR++T+ N D I+V NG+V E + L +
Sbjct: 1306 ASIDMETDTLIQRTIREAFQGCTVLVIAHRVTTVLNCDHILVMGNGKVVEFDRPEVLRKK 1365
Query: 1264 KGIYFSMVSVQA 1275
G F+ + A
Sbjct: 1366 PGSLFAALMATA 1377
>gi|118582255 ATP-binding cassette, sub-family C, member 8 [Homo
sapiens]
Length = 1581
Score = 218 bits (554), Expect = 4e-56
Identities = 204/911 (22%), Positives = 395/911 (43%), Gaps = 77/911 (8%)
Query: 407 VKILKGLNLKVQSGQTVALVGNSGCGKSTTVQL----MQRLY---------------DPT 447
+ L + +++ GQ +VG GCGKS+ + MQ++ DP+
Sbjct: 693 IPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPS 752
Query: 448 EGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEA 507
+ DIR R + SQ+P L T+ ENI + + ++
Sbjct: 753 PERETATDLDIRK------RGPVAYASQKPWLLNATVEENIIF-ESPFNKQRYKMVIEAC 805
Query: 508 NAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTE-SE 566
+ I LPH T +GERG LSGGQ+QRI++ARAL ++ ++ LD+ SALD S+
Sbjct: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
Query: 567 AVVQVALDKARKG--RTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFK 624
++Q + + + RT +++ H+L + +AD I DG I +G + + + F+
Sbjct: 866 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFE 925
Query: 625 --LVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKL 682
M E+E E + +E + SR L++ +D L
Sbjct: 926 HWKTLMNRQDQELEKETVTERKATEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNL 985
Query: 683 STKEALDESIPPVSFWRIMKLNLTEWPYFVVG--VFCAIINGGLQPAFAIIFSK------ 734
S+ IP WR L+ ++ VF ++ + A +K
Sbjct: 986 SSMLHQRAEIP----WRACAKYLSSAGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSAL 1041
Query: 735 -IIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVF 793
+ + + +++++F L + + + T G + KRL +
Sbjct: 1042 TLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLCLVTSVTVEWTGLKVAKRLHRSLL 1101
Query: 794 RSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGI-IISFI 852
++ + +F+ G++ R ++D + I S L ++++ + + +IS++
Sbjct: 1102 NRIILAPMRFFET--TPLGSILNRFSSDCNTIDQHIPSTLECLSRSTLLCVSALAVISYV 1159
Query: 853 YGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA-----TEAIENFRTV 907
+ L+A++P+ + ++ A +D ++L+ + ++ E +E T+
Sbjct: 1160 ----TPVFLVALLPLAIVCYFIQKYFRV--ASRDLQQLDDTTQLPLLSHFAETVEGLTTI 1213
Query: 908 VSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHK 967
+ E +F+ + L+ N++ + M Y +++
Sbjct: 1214 RAFRYEARFQQ---KLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNS 1270
Query: 968 LMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMI--IEKTPLIDSYSTEG 1025
L LV + + M ++ + A ++ + I + KT ++ S EG
Sbjct: 1271 LHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKT---EAESYEG 1327
Query: 1026 LMPNTL-------EGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKST 1078
L+ +L +G + + Y + PVL+ ++ + GQ + + G +G GKS+
Sbjct: 1328 LLAPSLIPKNWPDQGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSS 1386
Query: 1079 VVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSR 1138
R D G +++DG +I +L + LR+ L I+ Q+P+LF +I N+ D R
Sbjct: 1387 FSLAFFRMVDTFEGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNL---DPER 1443
Query: 1139 VVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILL 1198
S + A + A + +++LP + + G S GQ+Q +ARA VR+ I +
Sbjct: 1444 KCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFI 1503
Query: 1199 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQ 1258
+DEAT+++D +E ++Q+ + A RT + IAHR+ TI +ADL++V + G + E +
Sbjct: 1504 MDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPE 1563
Query: 1259 QLLAQKGIYFS 1269
+LL++K F+
Sbjct: 1564 KLLSRKDSVFA 1574
Score = 125 bits (313), Expect = 3e-28
Identities = 73/235 (31%), Positives = 127/235 (54%), Gaps = 2/235 (0%)
Query: 389 KGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTE 448
+G ++ +N+ Y S + +LK +N + GQ + + G +G GKS+ R+ D E
Sbjct: 1341 QGKIQIQNLSVRYDSSLK-PVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1399
Query: 449 GMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEAN 508
G + +DG DI + + LR + ++ Q+PVLF+ TI N+ R+ + + +A++ A
Sbjct: 1400 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERK-CSDSTLWEALEIAQ 1458
Query: 509 AYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAV 568
+ LP D ++ E G S GQ+Q +ARA VR I ++DEAT+++D +E +
Sbjct: 1459 LKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENI 1518
Query: 569 VQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 623
+Q + A RT + IAHR+ T+ +AD++ G I+E ++L+ K F
Sbjct: 1519 LQKVVMTAFADRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRKDSVF 1573
Score = 98.6 bits (244), Expect = 3e-20
Identities = 66/227 (29%), Positives = 120/227 (52%), Gaps = 22/227 (9%)
Query: 1048 PD-IPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVL---LDGKEIKR 1103
PD IP L +++ + +GQ +VG GCGKS+++ ++G V L EI
Sbjct: 690 PDGIPTLSNITIRIPRGQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGE 749
Query: 1104 -----------LNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEA 1152
L+++ R + SQ+P L + ++ ENI + + ++ A
Sbjct: 750 DPSPERETATDLDIR-KRGPVAYASQKPWLLNATVEENIIFESPFNKQRYKMVIEAC--- 805
Query: 1153 NIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEK 1212
++ I+ LP+ T++G++G LSGGQ+QRI++ARAL + +++ LD+ SALD
Sbjct: 806 SLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHANVVFLDDPFSALDIHLSD 865
Query: 1213 VVQEA--LDKAREG-RTCIVIAHRLSTIQNADLIVVFQNGRVKEHGT 1256
+ +A L+ R+ RT +++ H+L + +AD I+ ++G ++ GT
Sbjct: 866 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGT 912
>gi|9955970 ATP-binding cassette, sub-family C, member 3 isoform 1
[Homo sapiens]
Length = 1527
Score = 213 bits (543), Expect = 7e-55
Identities = 219/912 (24%), Positives = 399/912 (43%), Gaps = 86/912 (9%)
Query: 410 LKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREI 469
L L+++V G VA+VG GCGKS+ V + + EG V + G
Sbjct: 644 LHSLDIQVPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGKVHMKGS------------- 690
Query: 470 IGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGA 529
+ V Q+ + T+ EN+ +G+ + ++ ++ + LP T +GE+G
Sbjct: 691 VAYVPQQAWIQNCTLQENVLFGKA-LNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGI 749
Query: 530 QLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVV---QVALDKARKGRTTIVIA 586
LSGGQ+QR+++ARA+ + I LLD+ SA+D+ + + + G+T +++
Sbjct: 750 NLSGGQRQRVSLARAVYSDADIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVT 809
Query: 587 HRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNE--------VELE 638
H +S + D I DG + E G + L++ G + + + LE
Sbjct: 810 HGISFLPQTDFIIVLADGQVSEMGPYPALLQRNGSFANFLCNYAPDEDQGHLEDSWTALE 869
Query: 639 NAADESKSEIDAL-----EMSSNDSRSSLIRKRSTRR--------SVRGSQAQDRKLSTK 685
A D+ I+ +++ ND + +++K+ R+ +G R L
Sbjct: 870 GAEDKEALLIEDTLSNHTDLTDNDPVTYVVQKQFMRQLSALSSDGEGQGRPVPRRHLGPS 929
Query: 686 EAL-------DESIPPVSFWRIMKLNLTE-WPYFVVGVFCAIINGGL----QPAFAIIFS 733
E + D ++ I + L+ W Y C + L Q A AI +
Sbjct: 930 EKVQVTEAKADGALTQEEKAAIGTVELSVFWDYAKAVGLCTTLAICLLYVGQSAAAIGAN 989
Query: 734 KIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVF 793
+ +T ++++ N++L ++ ALGI+ L G + L +
Sbjct: 990 VWLSAWTNDAMADSRQNNTSLRLGVYAALGILQGFLVMLAAMAMAAGGIQAARVLHQALL 1049
Query: 794 RSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIY 853
+ +R S+FD +G + + D V + + ++ + N + +++
Sbjct: 1050 HNKIRSPQSFFDT--TPSGRILNCFSKDIYVVDEVLAPVILMLLNSFFNAISTLVVIMAS 1107
Query: 854 GWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIA--TEAIENFRTVVSLT 911
T+++L + + + V + + LK + + S + +E + + +
Sbjct: 1108 TPLFTVVILPLAVLYTL--VQRFYAATSRQLKRLESVSRSPIYSHFSETVTGASVIRAYN 1165
Query: 912 QEQKFEHMYAQSLQV------PYRNSLRKAHIFGITFSFTQAMMY---FSYAGCFRFGAY 962
+ + FE + + PY S R I G+ F +++ F+ G
Sbjct: 1166 RSRDFEIISDTKVDANQRSCYPYIISNRWLSI-GVEFVGNCVVLFAALFAVIGRSSLNPG 1224
Query: 963 LVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYS 1022
LV +S L V A+ + + + S I A + KT +
Sbjct: 1225 LVG---LSVSYSLQVTFALNWMIRMMSDLES--------NIVAVERVKEYSKTETEAPWV 1273
Query: 1023 TEGLMPNTLEGNVTFGEVVF-NYPTR--PDIP-VLQGLSLEVKKGQTLALVGSSGCGKST 1078
EG P EG GEV F NY R P + VL+ LSL V G+ + +VG +G GKS+
Sbjct: 1274 VEGSRPP--EGWPPRGEVEFRNYSVRYRPGLDLVLRDLSLHVHGGEKVGIVGRTGAGKSS 1331
Query: 1079 VVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSR 1138
+ L R + G++ +DG + + + LR+ L I+ Q+PILF ++ N+ D
Sbjct: 1332 MTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTIIPQDPILFSGTLRMNL---DPFG 1388
Query: 1139 VVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILL 1198
S+E+I A + +++H F+ S P + + G LS GQ+Q + +ARAL+R+ IL+
Sbjct: 1389 SYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENLSVGQRQLVCLARALLRKSRILV 1448
Query: 1199 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQ 1258
LDEAT+A+D E++ ++Q + + T + IAHRL+TI + ++V G V E +
Sbjct: 1449 LDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNTIMDYTRVLVLDKGVVAEFDSPA 1508
Query: 1259 QLLAQKGIYFSM 1270
L+A +GI++ M
Sbjct: 1509 NLIAARGIFYGM 1520
Score = 140 bits (354), Expect = 6e-33
Identities = 124/512 (24%), Positives = 236/512 (46%), Gaps = 24/512 (4%)
Query: 124 GVLVAAYIQVSFWCLAAG--RQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSK 181
G+L + ++ +AAG + + + H +R +FD G + + D+
Sbjct: 1019 GILQGFLVMLAAMAMAAGGIQAARVLHQALLHNKIRSPQSFFDTTPSGRILNCFSKDIYV 1078
Query: 182 INEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTD 241
++E + I M S + +V T+VIL ++ + L +A
Sbjct: 1079 VDEVLAPVILMLLNSFFNAISTLVVIMASTPLFTVVILPLAVLYTLVQRFYAATSRQLKR 1138
Query: 242 KELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITAN--ISI 299
E ++ + + E + + A+ + ++ E + +A + I +N +SI
Sbjct: 1139 LESVSRSPIYSHFSETVTGASVIRAYN-RSRDFEIISDTKVDANQRSCYPYIISNRWLSI 1197
Query: 300 GAAFL-----LIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEA 354
G F+ L A +A+ L G S+ L V F++ + +I A
Sbjct: 1198 GVEFVGNCVVLFAALFAVIGRSSLNPGLVG-LSVSYSLQVTFALNWMIRMMSDLESNIVA 1256
Query: 355 FANARGAAYEIFKIIDNKPSIDSYSK--SGHKPDNIKGNLEFRNVHFSYPSRKEVKILKG 412
+ E K P + S+ G P +G +EFRN Y ++ +L+
Sbjct: 1257 VERVK----EYSKTETEAPWVVEGSRPPEGWPP---RGEVEFRNYSVRYRPGLDL-VLRD 1308
Query: 413 LNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGV 472
L+L V G+ V +VG +G GKS+ + R+ + +G + +DG ++ I + LR + +
Sbjct: 1309 LSLHVHGGEKVGIVGRTGAGKSSMTLCLFRILEAAKGEIRIDGLNVADIGLHDLRSQLTI 1368
Query: 473 VSQEPVLFATTIAENIR-YGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQL 531
+ Q+P+LF+ T+ N+ +G + + ++I A++ ++ + F+ P D E G L
Sbjct: 1369 IPQDPILFSGTLRMNLDPFG--SYSEEDIWWALELSHLHTFVSSQPAGLDFQCSEGGENL 1426
Query: 532 SGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLST 591
S GQ+Q + +ARAL+R +IL+LDEAT+A+D E++ ++Q + T + IAHRL+T
Sbjct: 1427 SVGQRQLVCLARALLRKSRILVLDEATAAIDLETDNLIQATIRTQFDTCTVLTIAHRLNT 1486
Query: 592 VRNADVIAGFDDGVIVEKGNHDELMKEKGIYF 623
+ + + D GV+ E + L+ +GI++
Sbjct: 1487 IMDYTRVLVLDKGVVAEFDSPANLIAARGIFY 1518
Score = 115 bits (287), Expect = 3e-25
Identities = 108/436 (24%), Positives = 196/436 (44%), Gaps = 42/436 (9%)
Query: 847 IIISFIYGWQ-LTLLLLA----IVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAI 901
II++ + WQ L +LA +V +I + G V +KM + Q +K K + K+ +E +
Sbjct: 437 IILAIYFLWQNLGPSVLAGVAFMVLLIPLNGAVAVKMRAFQ-VKQMKLKDSRIKLMSEIL 495
Query: 902 ENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFG- 960
+ + E F + ++ LR A T +FT F +
Sbjct: 496 NGIKVLKLYAWEPSFLKQ-VEGIRQGELQLLRTAAYLHTTTTFTWMCSPFLVTLITLWVY 554
Query: 961 AYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDS 1020
Y+ + ++ E + S + + + + +A +S I + + L D
Sbjct: 555 VYVDPNNVLDAEKAFVSVSLFNILRLPLNMLPQLISNLTQASVSLKRIQQFLSQEEL-DP 613
Query: 1021 YSTE------GLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGC 1074
S E G G T+ + + P P L L ++V KG +A+VG GC
Sbjct: 614 QSVERKTISPGYAITIHSGTFTWAQ---DLP-----PTLHSLDIQVPKGALVAVVGPVGC 665
Query: 1075 GKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYG 1134
GKS++V L + L GKV + G + V Q+ + +C++ EN+ +G
Sbjct: 666 GKSSLVSALLGEMEKLEGKVHMKGS-------------VAYVPQQAWIQNCTLQENVLFG 712
Query: 1135 DNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQP 1194
+ ++ + + + + A +E LP T++G+KG LSGGQ+QR+++ARA+
Sbjct: 713 ---KALNPKRYQQTLEACALLADLEMLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDA 769
Query: 1195 HILLLDEATSALDTESEKVVQEAL---DKAREGRTCIVIAHRLSTIQNADLIVVFQNGRV 1251
I LLD+ SA+D+ K + + + + G+T +++ H +S + D I+V +G+V
Sbjct: 770 DIFLLDDPLSAVDSHVAKHIFDHVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQV 829
Query: 1252 KEHGTHQQLLAQKGIY 1267
E G + LL + G +
Sbjct: 830 SEMGPYPALLQRNGSF 845
>gi|42490749 ATP-binding cassette, sub-family B, member 7 [Homo
sapiens]
Length = 753
Score = 208 bits (529), Expect = 3e-53
Identities = 167/596 (28%), Positives = 278/596 (46%), Gaps = 43/596 (7%)
Query: 84 NLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQ 143
+L + N+ N SD +T M T Y AG ++ + + A
Sbjct: 168 SLNQMSGNMLNLSDAPNTVATM-----ATAVLIGYGVSRAGAAFFNEVRNAVFGKVAQNS 222
Query: 144 IHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTG 203
I +I K F + ++G+ G L+ + I+ + + F + F
Sbjct: 223 IRRIAKNVFLHLHNLDLGFHLSRQTGALSKAIDRGTRGISFVLS---ALVFNLLPIMFEV 279
Query: 204 FIVG----FTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLA 259
+V + G + LV L + + F + A AG A + L
Sbjct: 280 MLVSGVLYYKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDAGNAAIDSLL 339
Query: 260 AIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAIT---------ANISIGAAFLLIYASY 310
TV F ++ E +RY+ L+ + +K T A S+G +++ AS
Sbjct: 340 NYETVKYFNNERYEAQRYDGFLKTYETASLKSTSTLAMLNFGQSAIFSVGLTAIMVLASQ 399
Query: 311 ALAFWYGTTLVLSGEYSIGQVLTV---FFSVLIGAFSVGQASPSIEAFANARGAAYEIFK 367
+++G ++G ++ V F + + +G + + K
Sbjct: 400 G---------IVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYRETRQALIDMNTLFTLLK 450
Query: 368 IIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVG 427
+ + D S + + F NVHF Y + K+L G++ +V +G+ VA+VG
Sbjct: 451 V--DTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQ--KVLSGISFEVPAGKKVAIVG 506
Query: 428 NSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAEN 487
SG GKST V+L+ R Y+P +G + + GQ+I+ +++ LR +GVV Q+ VLF TI N
Sbjct: 507 GSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGVVPQDAVLFHNTIYYN 566
Query: 488 IRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVR 547
+ YG + + +E+ K A +D I+++PH +DT VGERG +LSGG+KQR+AIARA+++
Sbjct: 567 LLYGNISASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLKLSGGEKQRVAIARAILK 626
Query: 548 NPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIV 607
+P ++L DEATS+LD+ +E + A+ K RT+I IAHRLSTV +AD I D G +
Sbjct: 627 DPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLSTVVDADEIIVLDQGKVA 686
Query: 608 EKGNHDELM-KEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSL 662
E+G H L+ IY ++ Q++ ++N D K E +S + R L
Sbjct: 687 ERGTHHGLLANPHSIYSEMWHTQSS----RVQN-HDNPKWEAKKENISKEEERKKL 737
Score = 198 bits (503), Expect = 3e-50
Identities = 157/521 (30%), Positives = 250/521 (47%), Gaps = 47/521 (9%)
Query: 777 FGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRL---ANDAAQVKGAIGSRL 833
FGK + +R+ VF + D+ + TGAL+ + + V A+ L
Sbjct: 215 FGKVAQNSIRRIAKNVFLHLHNLDLGFH--LSRQTGALSKAIDRGTRGISFVLSALVFNL 272
Query: 834 AVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS 893
I + L +G++ + G Q L+ L + V + + ++ K +
Sbjct: 273 LPIMFEVM-LVSGVLY-YKCGAQFALVTLGTLGTYTAFTVAVTRWRTRFRIEMNKADNDA 330
Query: 894 GKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSY 953
G A +++ N+ TV E+ Y L+ SL+ T AM+ F
Sbjct: 331 GNAAIDSLLNYETVKYFNNERYEAQRYDGFLKTYETASLKSTS--------TLAMLNFGQ 382
Query: 954 AGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQV-----------------SSFAP 996
+ F G + ++L +V G + VG + +
Sbjct: 383 SAIFSVGLTAI---------MVLASQGIVAGTLTVGDLVMVNGLLFQLSLPLNFLGTVYR 433
Query: 997 DYAKAKISAAHIIMIIE-KTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQG 1055
+ +A I + +++ T + D L V F V F Y VL G
Sbjct: 434 ETRQALIDMNTLFTLLKVDTQIKDKVMASPLQITPQTATVAFDNVHFEYIEGQK--VLSG 491
Query: 1056 LSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGI 1115
+S EV G+ +A+VG SG GKST+V+LL RFY+P G + L G+ I+ ++++ LR +G+
Sbjct: 492 ISFEVPAGKKVAIVGGSGSGKSTIVRLLFRFYEPQKGSIYLAGQNIQDVSLESLRRAVGV 551
Query: 1116 VSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQ 1175
V Q+ +LF +I N+ YG+ S S EE+ AK A +H I +P+ Y T+VG++G +
Sbjct: 552 VPQDAVLFHNTIYYNLLYGNIS--ASPEEVYAVAKLAGLHDAILRMPHGYDTQVGERGLK 609
Query: 1176 LSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLS 1235
LSGG+KQR+AIARA+++ P ++L DEATS+LD+ +E+ + A+ + RT I IAHRLS
Sbjct: 610 LSGGEKQRVAIARAILKDPPVILYDEATSSLDSITEETILGAMKDVVKHRTSIFIAHRLS 669
Query: 1236 TIQNADLIVVFQNGRVKEHGTHQQLLAQ-KGIYFSMVSVQA 1275
T+ +AD I+V G+V E GTH LLA IY M Q+
Sbjct: 670 TVVDADEIIVLDQGKVAERGTHHGLLANPHSIYSEMWHTQS 710
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.136 0.384
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,799,868
Number of Sequences: 37866
Number of extensions: 1596777
Number of successful extensions: 5073
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 7
Number of HSP's that attempted gapping in prelim test: 4409
Number of HSP's gapped (non-prelim): 335
length of query: 1280
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1166
effective length of database: 13,930,794
effective search space: 16243305804
effective search space used: 16243305804
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.