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Search of human proteins with 126116565
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|126116565 MYC binding protein 2 [Homo sapiens]
(4640 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|126116565 MYC binding protein 2 [Homo sapiens] 9393 0.0
gi|61563742 hect domain and RLD 6 [Homo sapiens] 77 5e-13
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 76 7e-13
gi|20127580 BTB (POZ) domain containing 2 [Homo sapiens] 70 4e-11
gi|110825982 hect domain and RLD 5 [Homo sapiens] 69 8e-11
gi|13376848 BTB (POZ) domain containing 1 isoform 1 [Homo sapiens] 69 1e-10
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 69 1e-10
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 69 1e-10
gi|7657152 hect domain and RLD 3 [Homo sapiens] 69 1e-10
gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens] 67 4e-10
gi|225543407 BTB domain protein BDPL [Homo sapiens] 67 5e-10
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 66 9e-10
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 66 9e-10
gi|126032348 hect domain and RLD 2 [Homo sapiens] 65 2e-09
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 65 2e-09
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 65 2e-09
gi|4557445 regulator of chromosome condensation and BTB domain c... 63 8e-09
gi|7662402 BTB/POZ domain containing protein 3 isoform a [Homo s... 59 9e-08
gi|31317209 BTB/POZ domain containing protein 3 isoform b [Homo ... 59 9e-08
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 59 1e-07
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 59 1e-07
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 58 2e-07
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 56 7e-07
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 56 7e-07
gi|40316935 alsin isoform 1 [Homo sapiens] 56 9e-07
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 55 2e-06
gi|114796646 regulator of chromosome condensation 1 isoform b [H... 54 4e-06
gi|114796644 regulator of chromosome condensation 1 isoform a [H... 53 6e-06
gi|4502801 regulator of chromosome condensation 1 isoform c [Hom... 53 6e-06
gi|114796642 regulator of chromosome condensation 1 [Homo sapiens] 53 6e-06
>gi|126116565 MYC binding protein 2 [Homo sapiens]
Length = 4640
Score = 9393 bits (24373), Expect = 0.0
Identities = 4640/4640 (100%), Positives = 4640/4640 (100%)
Query: 1 MPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHP 60
MPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHP
Sbjct: 1 MPVPDGSVAAAGLGLGLPAADSRGHYQLLLSGRALADRYRRIYTAALNDRDQGGGSAGHP 60
Query: 61 ASRNKKILNKKKLKRKQKSKSKVKTRSKSENLENTVIIPDIKLHSNPSAFNIYCNVRHCV 120
ASRNKKILNKKKLKRKQKSKSKVKTRSKSENLENTVIIPDIKLHSNPSAFNIYCNVRHCV
Sbjct: 61 ASRNKKILNKKKLKRKQKSKSKVKTRSKSENLENTVIIPDIKLHSNPSAFNIYCNVRHCV 120
Query: 121 LEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSH 180
LEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSH
Sbjct: 121 LEWQKKEISLAAASKNSVQSGESDSDEEEESKEPPIKLPKIIEVGLCEVFELIKETRFSH 180
Query: 181 PSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALS 240
PSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALS
Sbjct: 181 PSLCLRSLQALLNVLQGQQPEGLQSEPPEVLESLFQLLLEITVRSTGMNDSTGQSLTALS 240
Query: 241 CACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLVGKIQIQ 300
CACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLVGKIQIQ
Sbjct: 241 CACLFSLVASWGETGRTLQAISAILTNNGSHACQTIQVPTILNSLQRSVQAVLVGKIQIQ 300
Query: 301 DWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGH 360
DWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGH
Sbjct: 301 DWFSNGIKKAALMHKWPLKEISVDEDDQCLLQNDGFFLYLLCKDGLYKIGSGYSGTVRGH 360
Query: 361 IYNSTSRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEG 420
IYNSTSRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEG
Sbjct: 361 IYNSTSRIRNRKEKKSWLGYAQGYLLYRDVNNHSMTAIRISPETLEQDGTVMLPDCHTEG 420
Query: 421 QNILFTDGEYINQIAASRDDGFVVRIFATSTEPVLQQELQLKLARKCLHACGISLFDLEK 480
QNILFTDGEYINQIAASRDDGFVVRIFATSTEPVLQQELQLKLARKCLHACGISLFDLEK
Sbjct: 421 QNILFTDGEYINQIAASRDDGFVVRIFATSTEPVLQQELQLKLARKCLHACGISLFDLEK 480
Query: 481 DLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITK 540
DLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITK
Sbjct: 481 DLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITK 540
Query: 541 SPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGK 600
SPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGK
Sbjct: 541 SPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGK 600
Query: 601 IVVYTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMK 660
IVVYTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMK
Sbjct: 601 IVVYTACNNGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMK 660
Query: 661 NGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGM 720
NGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGM
Sbjct: 661 NGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEEELDEKDEKSMMCPPGM 720
Query: 721 HKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACAREL 780
HKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACAREL
Sbjct: 721 HKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGESGCAVCGCCKACAREL 780
Query: 781 DGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRLEEGRGP 840
DGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRLEEGRGP
Sbjct: 781 DGQEARQRGILDAVKEMIPLDLLLAVPVPGVNIEEHLQLRQEEKRQRVIRRHRLEEGRGP 840
Query: 841 LVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDC 900
LVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDC
Sbjct: 841 LVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDC 900
Query: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA 960
ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA
Sbjct: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA 960
Query: 961 GSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASG 1020
GSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASG
Sbjct: 961 GSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASG 1020
Query: 1021 DQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDS 1080
DQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDS
Sbjct: 1021 DQTFLRIDEALINSHVLATSEIFASKHIIGLVPASISEPPPFKCLLINKVDGSCKTFNDS 1080
Query: 1081 EQEDLQGFGVCLDPVYDVIWRFRPNTRELWCYNAVVADARLPSAADMQSRCSILSPELAL 1140
EQEDLQGFGVCLDPVYDVIWRFRPNTRELWCYNAVVADARLPSAADMQSRCSILSPELAL
Sbjct: 1081 EQEDLQGFGVCLDPVYDVIWRFRPNTRELWCYNAVVADARLPSAADMQSRCSILSPELAL 1140
Query: 1141 PTGSRALTTRSHAALHILGCLDTLAAMQDLKMGVASTEEETQAVMKVYSKEDYSVVNRFE 1200
PTGSRALTTRSHAALHILGCLDTLAAMQDLKMGVASTEEETQAVMKVYSKEDYSVVNRFE
Sbjct: 1141 PTGSRALTTRSHAALHILGCLDTLAAMQDLKMGVASTEEETQAVMKVYSKEDYSVVNRFE 1200
Query: 1201 SHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDL 1260
SHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDL
Sbjct: 1201 SHGGGWGYSAHSVEAIRFSADTDILLGGLGLFGGRGEYTAKIKLFELGPDGGDHETDGDL 1260
Query: 1261 LAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGV 1320
LAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGV
Sbjct: 1261 LAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQASITTDDGV 1320
Query: 1321 VFQFKSSKKSNNGTDVNAGQIPQLLYRLPTSDGSASKGKQQTSEPVHILKRSFARTVSVE 1380
VFQFKSSKKSNNGTDVNAGQIPQLLYRLPTSDGSASKGKQQTSEPVHILKRSFARTVSVE
Sbjct: 1321 VFQFKSSKKSNNGTDVNAGQIPQLLYRLPTSDGSASKGKQQTSEPVHILKRSFARTVSVE 1380
Query: 1381 CFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIY 1440
CFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIY
Sbjct: 1381 CFESLLSILHWSWTTLVLGVEELRGLKGFQFTATLLDLERLRFVGTCCLRLLRVYTCEIY 1440
Query: 1441 PVSATGKAVVEETSKLAECIGKTRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAV 1500
PVSATGKAVVEETSKLAECIGKTRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAV
Sbjct: 1441 PVSATGKAVVEETSKLAECIGKTRTLLRKILSEGVDHCMVKLDNDPQGYLSQPLSLLEAV 1500
Query: 1501 LQECHNTFTACFHSFYPTPALQWACLCDLLNCLDQDIQEANFKTSSSRLLAAVMSALCHT 1560
LQECHNTFTACFHSFYPTPALQWACLCDLLNCLDQDIQEANFKTSSSRLLAAVMSALCHT
Sbjct: 1501 LQECHNTFTACFHSFYPTPALQWACLCDLLNCLDQDIQEANFKTSSSRLLAAVMSALCHT 1560
Query: 1561 SVKLTSIFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSF 1620
SVKLTSIFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSF
Sbjct: 1561 SVKLTSIFPIAYDGEVLLRSIVKQVSTENDSTLVHRFPLLVAHMEKLSQSEENISGMTSF 1620
Query: 1621 REVLEKMLVIVVLPVRNSLRRENELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSL 1680
REVLEKMLVIVVLPVRNSLRRENELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSL
Sbjct: 1621 REVLEKMLVIVVLPVRNSLRRENELFSSHLVSNTCGLLASIVSELTASALGSEVDGLNSL 1680
Query: 1681 HSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGGGGIHEYELEVLV 1740
HSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGGGGIHEYELEVLV
Sbjct: 1681 HSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGGGGIHEYELEVLV 1740
Query: 1741 DDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGS 1800
DDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGS
Sbjct: 1741 DDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGS 1800
Query: 1801 RTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSK 1860
RTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSK
Sbjct: 1801 RTANGDGGMTTVQCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYYRSEFDGDLQSQLLSK 1860
Query: 1861 ANEEDKNCSRALSVVSTVVRASKDLLHRALAVDADDIPELLSSSSLFSMLLPLIIAYIGP 1920
ANEEDKNCSRALSVVSTVVRASKDLLHRALAVDADDIPELLSSSSLFSMLLPLIIAYIGP
Sbjct: 1861 ANEEDKNCSRALSVVSTVVRASKDLLHRALAVDADDIPELLSSSSLFSMLLPLIIAYIGP 1920
Query: 1921 VAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSS 1980
VAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSS
Sbjct: 1921 VAAAIPKVAVEVFGLVQQLLPSVAILNQKYAPPAFNPNQSTDSTTGNQPEQGLSACTTSS 1980
Query: 1981 HYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSG 2040
HYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSG
Sbjct: 1981 HYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQNSG 2040
Query: 2041 YGPKLTSVHENLNSWIELKKFSGSSGWPTMVLVLPGNEALFSLETASDYVKDDKASFYGF 2100
YGPKLTSVHENLNSWIELKKFSGSSGWPTMVLVLPGNEALFSLETASDYVKDDKASFYGF
Sbjct: 2041 YGPKLTSVHENLNSWIELKKFSGSSGWPTMVLVLPGNEALFSLETASDYVKDDKASFYGF 2100
Query: 2101 KCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDLEILEEAAL 2160
KCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDLEILEEAAL
Sbjct: 2101 KCFAIGYEFSPGPDEGVIQLEKELANLGGVCAAALMKKDLALPIGNELEEDLEILEEAAL 2160
Query: 2161 QVCKTHSGILGKGLALSHSPTILEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARW 2220
QVCKTHSGILGKGLALSHSPTILEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARW
Sbjct: 2161 QVCKTHSGILGKGLALSHSPTILEALEGNLPLQIQSNEQSFLDDFIACVPGSSGGRLARW 2220
Query: 2221 LQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKVEVKAVPVSQKKM 2280
LQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKVEVKAVPVSQKKM
Sbjct: 2221 LQPDSYADPQKTSLILNKDDIRCGWPTTITVQTKDQYGDVVHVPNMKVEVKAVPVSQKKM 2280
Query: 2281 SLQQDQAKKPQRIPGSPAVTAASSNTDMTYGGLASPKLDVSYEPMIVKEARYIAITMMKV 2340
SLQQDQAKKPQRIPGSPAVTAASSNTDMTYGGLASPKLDVSYEPMIVKEARYIAITMMKV
Sbjct: 2281 SLQQDQAKKPQRIPGSPAVTAASSNTDMTYGGLASPKLDVSYEPMIVKEARYIAITMMKV 2340
Query: 2341 YENYSFEELRFASPTPKRPSENMLIRVNNDGTYCANWTPGAIGLYTLHVTIDGIEIDAGL 2400
YENYSFEELRFASPTPKRPSENMLIRVNNDGTYCANWTPGAIGLYTLHVTIDGIEIDAGL
Sbjct: 2341 YENYSFEELRFASPTPKRPSENMLIRVNNDGTYCANWTPGAIGLYTLHVTIDGIEIDAGL 2400
Query: 2401 EVKVKDPPKGMIPPGTQLVKPKSEPQPNKVRKFVAKDSAGLRIRSHPSLQSEQIGIVKVN 2460
EVKVKDPPKGMIPPGTQLVKPKSEPQPNKVRKFVAKDSAGLRIRSHPSLQSEQIGIVKVN
Sbjct: 2401 EVKVKDPPKGMIPPGTQLVKPKSEPQPNKVRKFVAKDSAGLRIRSHPSLQSEQIGIVKVN 2460
Query: 2461 GTITFIDEIHNDDGVWLRLNDETIKKYVPNMNGYTEAWCLSFNQHLGKSLLVPVDESKTN 2520
GTITFIDEIHNDDGVWLRLNDETIKKYVPNMNGYTEAWCLSFNQHLGKSLLVPVDESKTN
Sbjct: 2461 GTITFIDEIHNDDGVWLRLNDETIKKYVPNMNGYTEAWCLSFNQHLGKSLLVPVDESKTN 2520
Query: 2521 TDDFFKDINSCCPQEATMQEQDMPFLRGGPGMYKVVKTGPSGHNIRSCPNLRGIPIGMLV 2580
TDDFFKDINSCCPQEATMQEQDMPFLRGGPGMYKVVKTGPSGHNIRSCPNLRGIPIGMLV
Sbjct: 2521 TDDFFKDINSCCPQEATMQEQDMPFLRGGPGMYKVVKTGPSGHNIRSCPNLRGIPIGMLV 2580
Query: 2581 LGNKVKAVGEVTNSEGTWVQLDQNSMVEFCESDEGEAWSLARDRGGNQYLRHEDEQALLD 2640
LGNKVKAVGEVTNSEGTWVQLDQNSMVEFCESDEGEAWSLARDRGGNQYLRHEDEQALLD
Sbjct: 2581 LGNKVKAVGEVTNSEGTWVQLDQNSMVEFCESDEGEAWSLARDRGGNQYLRHEDEQALLD 2640
Query: 2641 QNSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKH 2700
QNSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKH
Sbjct: 2641 QNSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKH 2700
Query: 2701 SRSLKPDGRMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTL 2760
SRSLKPDGRMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTL
Sbjct: 2701 SRSLKPDGRMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTL 2760
Query: 2761 KSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPV 2820
KSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPV
Sbjct: 2761 KSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPV 2820
Query: 2821 KTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRA 2880
KTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRA
Sbjct: 2821 KTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRA 2880
Query: 2881 PSPHVVQENLHSEVVEVCTSSTLKTNSLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKD 2940
PSPHVVQENLHSEVVEVCTSSTLKTNSLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKD
Sbjct: 2881 PSPHVVQENLHSEVVEVCTSSTLKTNSLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKD 2940
Query: 2941 EQEMRASPKISRKCANRHTRPKKEKSSFLFKGDGSKPLEPAKQAMSPSVAECARAVFASF 3000
EQEMRASPKISRKCANRHTRPKKEKSSFLFKGDGSKPLEPAKQAMSPSVAECARAVFASF
Sbjct: 2941 EQEMRASPKISRKCANRHTRPKKEKSSFLFKGDGSKPLEPAKQAMSPSVAECARAVFASF 3000
Query: 3001 LWHEGIVHDAMACSSFLKFHPELSKEHAPIRSSLNSQQPTEEKETKLKNRHSLEISSALN 3060
LWHEGIVHDAMACSSFLKFHPELSKEHAPIRSSLNSQQPTEEKETKLKNRHSLEISSALN
Sbjct: 3001 LWHEGIVHDAMACSSFLKFHPELSKEHAPIRSSLNSQQPTEEKETKLKNRHSLEISSALN 3060
Query: 3061 MFNIAPHGPDISKMGSINKNKVLSMLKEPPLHEKCEDGKTETTFEMSMHNTMKSKSPLPL 3120
MFNIAPHGPDISKMGSINKNKVLSMLKEPPLHEKCEDGKTETTFEMSMHNTMKSKSPLPL
Sbjct: 3061 MFNIAPHGPDISKMGSINKNKVLSMLKEPPLHEKCEDGKTETTFEMSMHNTMKSKSPLPL 3120
Query: 3121 TLQHLVAFWEDISLATIKAASQNMIFPSPGSCAVLKKKECEKENKKSKKEKKKKEKAEVR 3180
TLQHLVAFWEDISLATIKAASQNMIFPSPGSCAVLKKKECEKENKKSKKEKKKKEKAEVR
Sbjct: 3121 TLQHLVAFWEDISLATIKAASQNMIFPSPGSCAVLKKKECEKENKKSKKEKKKKEKAEVR 3180
Query: 3181 PRGNLFGEMAQLAVGGPEKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHF 3240
PRGNLFGEMAQLAVGGPEKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHF
Sbjct: 3181 PRGNLFGEMAQLAVGGPEKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHF 3240
Query: 3241 CGGWAGNCGDGGIGGSTWYLVCDRCREKYLREKQAAAREKVKQSRRKPMQVKTPRALPTM 3300
CGGWAGNCGDGGIGGSTWYLVCDRCREKYLREKQAAAREKVKQSRRKPMQVKTPRALPTM
Sbjct: 3241 CGGWAGNCGDGGIGGSTWYLVCDRCREKYLREKQAAAREKVKQSRRKPMQVKTPRALPTM 3300
Query: 3301 EAHQVIKANALFLLSLSSAAEPSILCYHPAKPFQSQLPSVKEGISEDLPVKMPCLYLQTL 3360
EAHQVIKANALFLLSLSSAAEPSILCYHPAKPFQSQLPSVKEGISEDLPVKMPCLYLQTL
Sbjct: 3301 EAHQVIKANALFLLSLSSAAEPSILCYHPAKPFQSQLPSVKEGISEDLPVKMPCLYLQTL 3360
Query: 3361 ARHHHENFVGYQDDNLFQDEMRYLRSTSVPAPYISVTPDASPNVFEEPESNMKSMPPSLE 3420
ARHHHENFVGYQDDNLFQDEMRYLRSTSVPAPYISVTPDASPNVFEEPESNMKSMPPSLE
Sbjct: 3361 ARHHHENFVGYQDDNLFQDEMRYLRSTSVPAPYISVTPDASPNVFEEPESNMKSMPPSLE 3420
Query: 3421 TSPITDTDLAKRTVFQRSYSVVASEYDKQHSILPARVKAIPRRRVNSGDTEVGSSLLRHP 3480
TSPITDTDLAKRTVFQRSYSVVASEYDKQHSILPARVKAIPRRRVNSGDTEVGSSLLRHP
Sbjct: 3421 TSPITDTDLAKRTVFQRSYSVVASEYDKQHSILPARVKAIPRRRVNSGDTEVGSSLLRHP 3480
Query: 3481 SPELSRLISAHSSLSKGERNFQWPVLAFVIQHHDLEGLEIAMKQALRKSACRVFAMEAFN 3540
SPELSRLISAHSSLSKGERNFQWPVLAFVIQHHDLEGLEIAMKQALRKSACRVFAMEAFN
Sbjct: 3481 SPELSRLISAHSSLSKGERNFQWPVLAFVIQHHDLEGLEIAMKQALRKSACRVFAMEAFN 3540
Query: 3541 WLLCNVIQTTSLHDILWHFVASLTPAPVEPEEEEDEENKTSKENSEQEKDTRVCEHPLSD 3600
WLLCNVIQTTSLHDILWHFVASLTPAPVEPEEEEDEENKTSKENSEQEKDTRVCEHPLSD
Sbjct: 3541 WLLCNVIQTTSLHDILWHFVASLTPAPVEPEEEEDEENKTSKENSEQEKDTRVCEHPLSD 3600
Query: 3601 IVIAGEAAHPLPHTFHRLLQTISDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLHQSNV 3660
IVIAGEAAHPLPHTFHRLLQTISDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLHQSNV
Sbjct: 3601 IVIAGEAAHPLPHTFHRLLQTISDLMMSLPSGSSLQQMALRCWSLKFKQSDHQFLHQSNV 3660
Query: 3661 FHHINNILSKSDDGDSEESFSISIQSGFEAMSQELCIVMCLKDLTSIVDIKTSSRPAMIG 3720
FHHINNILSKSDDGDSEESFSISIQSGFEAMSQELCIVMCLKDLTSIVDIKTSSRPAMIG
Sbjct: 3661 FHHINNILSKSDDGDSEESFSISIQSGFEAMSQELCIVMCLKDLTSIVDIKTSSRPAMIG 3720
Query: 3721 SLTDGSTETFWESGDEDKNKTKNITINCVKGINARYVSVHVDNSRDLGNKVTSMTFLTGK 3780
SLTDGSTETFWESGDEDKNKTKNITINCVKGINARYVSVHVDNSRDLGNKVTSMTFLTGK
Sbjct: 3721 SLTDGSTETFWESGDEDKNKTKNITINCVKGINARYVSVHVDNSRDLGNKVTSMTFLTGK 3780
Query: 3781 AVEDLCRIKQVDLDSRHIGWVTSELPGGDNHIIKIELKGPENTLRVRQVKVLGWKDGEST 3840
AVEDLCRIKQVDLDSRHIGWVTSELPGGDNHIIKIELKGPENTLRVRQVKVLGWKDGEST
Sbjct: 3781 AVEDLCRIKQVDLDSRHIGWVTSELPGGDNHIIKIELKGPENTLRVRQVKVLGWKDGEST 3840
Query: 3841 KIAGQISASVAQQRNCEAETLRVFRLITSQVFGKLISGDAEPTPEQEEKALLSSPEGEEK 3900
KIAGQISASVAQQRNCEAETLRVFRLITSQVFGKLISGDAEPTPEQEEKALLSSPEGEEK
Sbjct: 3841 KIAGQISASVAQQRNCEAETLRVFRLITSQVFGKLISGDAEPTPEQEEKALLSSPEGEEK 3900
Query: 3901 VYNATSDADLKEHMVGIIFSRSKLTNLQKQVCAHIVQAIRMEATRVREEWEHAISSKENA 3960
VYNATSDADLKEHMVGIIFSRSKLTNLQKQVCAHIVQAIRMEATRVREEWEHAISSKENA
Sbjct: 3901 VYNATSDADLKEHMVGIIFSRSKLTNLQKQVCAHIVQAIRMEATRVREEWEHAISSKENA 3960
Query: 3961 NSQPNDEDASSDAYCFELLSMVLALSGSNVGRQYLAQQLTLLQDLFSLLHTASPRVQRQV 4020
NSQPNDEDASSDAYCFELLSMVLALSGSNVGRQYLAQQLTLLQDLFSLLHTASPRVQRQV
Sbjct: 3961 NSQPNDEDASSDAYCFELLSMVLALSGSNVGRQYLAQQLTLLQDLFSLLHTASPRVQRQV 4020
Query: 4021 TSLLRRVLPEVTPSRLASIIGVKSLPPADISDIIHSTEKGDWNKLGILDMFLGCIAKALT 4080
TSLLRRVLPEVTPSRLASIIGVKSLPPADISDIIHSTEKGDWNKLGILDMFLGCIAKALT
Sbjct: 4021 TSLLRRVLPEVTPSRLASIIGVKSLPPADISDIIHSTEKGDWNKLGILDMFLGCIAKALT 4080
Query: 4081 VQLKAKGTTITGTAGTTVGKGVTTVTLPMIFNSSYLRRGESHWWMKGSTPTQISEIIIKL 4140
VQLKAKGTTITGTAGTTVGKGVTTVTLPMIFNSSYLRRGESHWWMKGSTPTQISEIIIKL
Sbjct: 4081 VQLKAKGTTITGTAGTTVGKGVTTVTLPMIFNSSYLRRGESHWWMKGSTPTQISEIIIKL 4140
Query: 4141 IKDMAAGHLSEAWSRVTKNAIAETIIALTKMEEEFRSPVRCIATTRLWLALASLCVLDQD 4200
IKDMAAGHLSEAWSRVTKNAIAETIIALTKMEEEFRSPVRCIATTRLWLALASLCVLDQD
Sbjct: 4141 IKDMAAGHLSEAWSRVTKNAIAETIIALTKMEEEFRSPVRCIATTRLWLALASLCVLDQD 4200
Query: 4201 HVDRLSSGRWMGKDGQQKQMPMCDNHDDGETAAIILCNVCGNLCTDCDRFLHLHRRTKTH 4260
HVDRLSSGRWMGKDGQQKQMPMCDNHDDGETAAIILCNVCGNLCTDCDRFLHLHRRTKTH
Sbjct: 4201 HVDRLSSGRWMGKDGQQKQMPMCDNHDDGETAAIILCNVCGNLCTDCDRFLHLHRRTKTH 4260
Query: 4261 QRQVFKEEEEAIKVDLHEGCGRTKLFWLMALADSKTMKAMVEFREHTGKPTTSSSEACRF 4320
QRQVFKEEEEAIKVDLHEGCGRTKLFWLMALADSKTMKAMVEFREHTGKPTTSSSEACRF
Sbjct: 4261 QRQVFKEEEEAIKVDLHEGCGRTKLFWLMALADSKTMKAMVEFREHTGKPTTSSSEACRF 4320
Query: 4321 CGSRSGTELSAVGSVCSDADCQEYAKIACSKTHPCGHPCGGVKNEEHCLPCLHGCDKSAT 4380
CGSRSGTELSAVGSVCSDADCQEYAKIACSKTHPCGHPCGGVKNEEHCLPCLHGCDKSAT
Sbjct: 4321 CGSRSGTELSAVGSVCSDADCQEYAKIACSKTHPCGHPCGGVKNEEHCLPCLHGCDKSAT 4380
Query: 4381 SLKQDADDMCMICFTEALSAAPAIQLDCSHIFHLQCCRRVLENRWLGPRITFGFISCPIC 4440
SLKQDADDMCMICFTEALSAAPAIQLDCSHIFHLQCCRRVLENRWLGPRITFGFISCPIC
Sbjct: 4381 SLKQDADDMCMICFTEALSAAPAIQLDCSHIFHLQCCRRVLENRWLGPRITFGFISCPIC 4440
Query: 4441 KNKINHIVLKDLLDPIKELYEDVRRKALMRLEYEGLHKSEAITTPGVRFYNDPAGYAMNR 4500
KNKINHIVLKDLLDPIKELYEDVRRKALMRLEYEGLHKSEAITTPGVRFYNDPAGYAMNR
Sbjct: 4441 KNKINHIVLKDLLDPIKELYEDVRRKALMRLEYEGLHKSEAITTPGVRFYNDPAGYAMNR 4500
Query: 4501 YAYYVCYKCRKAYFGGEARCDAEAGRGDDYDPRELICGACSDVSRAQMCPKHGTDFLEYK 4560
YAYYVCYKCRKAYFGGEARCDAEAGRGDDYDPRELICGACSDVSRAQMCPKHGTDFLEYK
Sbjct: 4501 YAYYVCYKCRKAYFGGEARCDAEAGRGDDYDPRELICGACSDVSRAQMCPKHGTDFLEYK 4560
Query: 4561 CRYCCSVAVFFCFGTTHFCNACHDDFQRMTSIPKEELPHCPAGPKGKQLEGTECPLHVVH 4620
CRYCCSVAVFFCFGTTHFCNACHDDFQRMTSIPKEELPHCPAGPKGKQLEGTECPLHVVH
Sbjct: 4561 CRYCCSVAVFFCFGTTHFCNACHDDFQRMTSIPKEELPHCPAGPKGKQLEGTECPLHVVH 4620
Query: 4621 PPTGEEFALGCGVCRNAHTF 4640
PPTGEEFALGCGVCRNAHTF
Sbjct: 4621 PPTGEEFALGCGVCRNAHTF 4640
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 76.6 bits (187), Expect = 5e-13
Identities = 51/157 (32%), Positives = 80/157 (50%), Gaps = 7/157 (4%)
Query: 860 RSHPAQLKHKRDKHKDGSGERGEKDAS--KITTYPPGSVRFDCELRAVQVSCGFHHSVVL 917
+ H + HK G+G G+ K ++ P + +++ +QVSCG +HS+ L
Sbjct: 84 KEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLAL 143
Query: 918 MENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPG-PSTQVTAGSNHTAVLLMDGQVF 975
++ V+++G HGQLG G + S+ P V++L G P QV AG H+ L + G F
Sbjct: 144 SKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSF 203
Query: 976 TFGSFSKGQLGRPILDVPYWNAKP---APMPNIGSKY 1009
+GS S GQL +VP + KP + N+G Y
Sbjct: 204 GWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVY 240
Score = 62.8 bits (151), Expect = 8e-09
Identities = 51/201 (25%), Positives = 89/201 (44%), Gaps = 29/201 (14%)
Query: 495 ILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSP-------KIVHF 547
++ G+E +L G+++ G +G G++ E+ T KI+
Sbjct: 79 LVSCGKEHSLAVCHKGRVFAWGAGS-----EGQLGIGEFKEISFTPKKIMTLNDIKIIQV 133
Query: 548 SVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTAC 607
S GH H+L +++D +F G S G+ G + Q+ P +++ +EG + A
Sbjct: 134 SCGH--YHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASP---QRVRSLEGIPLAQVAA 188
Query: 608 NNGSSSVISKDGELYMFGKDA------------IYSDSSSLVTDLKGHFVTQVAMGKAHT 655
S +S G + +G ++ + S+ V LK V ++ G AHT
Sbjct: 189 GGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCGDAHT 248
Query: 656 CVLMKNGEVWTFGVNNKGQCG 676
VL ++G+V+TFG N GQ G
Sbjct: 249 AVLTQDGKVFTFGDNRSGQLG 269
Score = 60.1 bits (144), Expect = 5e-08
Identities = 32/78 (41%), Positives = 46/78 (58%), Gaps = 1/78 (1%)
Query: 902 LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAG 961
L V +SCG H+ VL ++G V+TFG + GQLG+ + P LV+ + G +Q+ G
Sbjct: 236 LGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGLVSQIDCG 295
Query: 962 SNHT-AVLLMDGQVFTFG 978
S HT A + GQV +FG
Sbjct: 296 SYHTLAYVHTTGQVVSFG 313
Score = 53.9 bits (128), Expect = 4e-06
Identities = 32/82 (39%), Positives = 42/82 (51%), Gaps = 2/82 (2%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRG-CPTLVQALPG-PSTQVTAGSNH 964
VSCG HS+ + G V+ +G G GQLG G+ P + L QV+ G H
Sbjct: 80 VSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYH 139
Query: 965 TAVLLMDGQVFTFGSFSKGQLG 986
+ L D QVF++G S GQLG
Sbjct: 140 SLALSKDSQVFSWGKNSHGQLG 161
Score = 47.0 bits (110), Expect = 4e-04
Identities = 28/83 (33%), Positives = 42/83 (50%), Gaps = 1/83 (1%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQ-VTAGSN 963
+Q + G HS++L+ N V + G GQLG P +QAL V+ G
Sbjct: 26 LQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKE 85
Query: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
H+ + G+VF +G+ S+GQLG
Sbjct: 86 HSLAVCHKGRVFAWGAGSEGQLG 108
Score = 46.2 bits (108), Expect = 8e-04
Identities = 33/85 (38%), Positives = 39/85 (45%), Gaps = 4/85 (4%)
Query: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVN---SRGCPTLVQALPGPST-QVTAG 961
QV+ G HS L G + +G GQL N P V AL ++ G
Sbjct: 185 QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISCG 244
Query: 962 SNHTAVLLMDGQVFTFGSFSKGQLG 986
HTAVL DG+VFTFG GQLG
Sbjct: 245 DAHTAVLTQDGKVFTFGDNRSGQLG 269
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 76.3 bits (186), Expect = 7e-13
Identities = 39/83 (46%), Positives = 55/83 (66%), Gaps = 2/83 (2%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAGSNH 964
V VS G+ HS + E+G++YT+G G G+LGHGD NSR PTLV+ + +V+ GS+H
Sbjct: 514 VCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISNVG-EVSCGSSH 572
Query: 965 TAVLLMDGQ-VFTFGSFSKGQLG 986
T L DG+ V++FG G+LG
Sbjct: 573 TIALSKDGRTVWSFGGGDNGKLG 595
Score = 71.2 bits (173), Expect = 2e-11
Identities = 36/77 (46%), Positives = 44/77 (57%), Gaps = 6/77 (7%)
Query: 3198 EKDTICELCGESHPYPVTYHMRQAHPGCGRYAGGQGYNSIGHFCGGW-AGNCGDGGIGGS 3256
E+ +CELC E HM++ HPGCGR A QGY S G + GW G CG G+
Sbjct: 2976 EEVVVCELC-ECSVVSFNQHMKRNHPGCGRSANRQGYRSNGSYVDGWFGGECG----SGN 3030
Query: 3257 TWYLVCDRCREKYLREK 3273
+YL+C CREKYL K
Sbjct: 3031 PYYLLCGTCREKYLAMK 3047
Score = 68.9 bits (167), Expect = 1e-10
Identities = 37/84 (44%), Positives = 51/84 (60%), Gaps = 2/84 (2%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAGSN 963
VQ+SCGF HS V+ +G ++TFG G +G+LG G+ +++ P V AL G QV G N
Sbjct: 4137 VQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLN 4196
Query: 964 HTAVLLMDG-QVFTFGSFSKGQLG 986
HT + DG V+ FG G+LG
Sbjct: 4197 HTLAVSADGSMVWAFGDGDYGKLG 4220
Score = 68.6 bits (166), Expect = 1e-10
Identities = 34/81 (41%), Positives = 55/81 (67%), Gaps = 2/81 (2%)
Query: 908 SCGFH-HSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNHT 965
SCG HS+ L E+G+V+++G G +G+LGHG+ + + P ++AL G Q++ G H+
Sbjct: 4087 SCGSDGHSMALTESGEVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHS 4146
Query: 966 AVLLMDGQVFTFGSFSKGQLG 986
AV+ DG++FTFG+ G+LG
Sbjct: 4147 AVVTSDGKLFTFGNGDYGRLG 4167
Score = 67.8 bits (164), Expect = 2e-10
Identities = 54/198 (27%), Positives = 91/198 (45%), Gaps = 19/198 (9%)
Query: 491 EESAILGAGREFALMKTANGKIYY--TGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFS 548
EE + G + + + T++GK++ G Y LG+ G ++ K + +T
Sbjct: 4134 EEVVQMSCGFKHSAVVTSDGKLFTFGNGDYGRLGL---GNTSNKKLPERVTALEGYQIGQ 4190
Query: 549 VGHDGSHALLVAEDGSIFFT-GSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTAC 607
V +H L V+ DGS+ + G G+ G + + S P+KI + G + AC
Sbjct: 4191 VACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSS----PQKIDVLCGIGIKKVAC 4246
Query: 608 NNGSSSVISKDGELYMFGKDAIYS---------DSSSLVTDLKGHFVTQVAMGKAHTCVL 658
S ++KDG +Y FG+D + + + L G + VA+G HT L
Sbjct: 4247 GTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLAL 4306
Query: 659 MKNGEVWTFGVNNKGQCG 676
NG+V+ +G N++GQ G
Sbjct: 4307 ASNGDVYAWGSNSEGQLG 4324
Score = 67.0 bits (162), Expect = 4e-10
Identities = 59/200 (29%), Positives = 96/200 (48%), Gaps = 23/200 (11%)
Query: 492 ESAILGAGREFALMKTANGKIYYTGK--YQSLGI-KQGGPSAGKWVELPITKSPKIVHFS 548
++ + AG+ + + +G + GK Y LG+ S K + +S K V S
Sbjct: 404 DAQTIEAGQYCTFVISTDGSVRACGKGSYGRLGLGDSNNQSTLKKLTFEPHRSIKKVSSS 463
Query: 549 VGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIK--MEGKIVVYTA 606
G DG H L +G +F G G+ G S + K K+I+ ++GK+VV +
Sbjct: 464 KGSDG-HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQ-----KYPKLIQGPLQGKVVVCVS 517
Query: 607 CNNGSSSVISKDGELYMFGKDAI----YSDSSS-----LVTDLKGHFVTQVAMGKAHTCV 657
S+ +++DGELY +G+ + DS+S LV D+ V +V+ G +HT
Sbjct: 518 AGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN--VGEVSCGSSHTIA 575
Query: 658 LMKNGE-VWTFGVNNKGQCG 676
L K+G VW+FG + G+ G
Sbjct: 576 LSKDGRTVWSFGGGDNGKLG 595
Score = 65.5 bits (158), Expect = 1e-09
Identities = 42/139 (30%), Positives = 69/139 (49%), Gaps = 15/139 (10%)
Query: 548 SVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTAC 607
S G DG H++ + E G +F G G+ G R++ +P++I ++G+ VV +C
Sbjct: 4087 SCGSDG-HSMALTESGEVFSWGDGDYGKLGHGNSDRQR----RPRQIEALQGEEVVQMSC 4141
Query: 608 NNGSSSVISKDGELYMFGK---------DAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVL 658
S+V++ DG+L+ FG + VT L+G+ + QVA G HT +
Sbjct: 4142 GFKHSAVVTSDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAV 4201
Query: 659 MKNGE-VWTFGVNNKGQCG 676
+G VW FG + G+ G
Sbjct: 4202 SADGSMVWAFGDGDYGKLG 4220
Score = 64.7 bits (156), Expect = 2e-09
Identities = 52/211 (24%), Positives = 96/211 (45%), Gaps = 18/211 (8%)
Query: 496 LGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSH 555
+ AG + T +G++Y G+ G G S + + + + S G SH
Sbjct: 516 VSAGYRHSAAVTEDGELYTWGE-GDFGRLGHGDSNSRNIPTLVKDISNVGEVSCG--SSH 572
Query: 556 ALLVAEDG-SIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614
+ +++DG +++ G G+ G +R YKPK I ++G + + SS
Sbjct: 573 TIALSKDGRTVWSFGGGDNGKLGHGDTNR----VYKPKVIEALQGMFIRKVCAGSQSSLA 628
Query: 615 ISKDGELYMFGKDAIYSDSSS--------LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWT 666
++ G++Y +G A SS L+ +L + V++G +H L + EV+
Sbjct: 629 LTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYA 688
Query: 667 FGVNNKGQCGR--DTGAMNQGGKGFGVENMA 695
+G N+ GQCG+ TG + + K G++ +A
Sbjct: 689 WGNNSMGQCGQGNSTGPITKPKKVSGLDGIA 719
Score = 58.2 bits (139), Expect = 2e-07
Identities = 31/75 (41%), Positives = 47/75 (62%), Gaps = 2/75 (2%)
Query: 906 QVSCGFHHSVVLMENG-DVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGP-STQVTAGSN 963
+VSCG H++ L ++G V++FG G +G+LGHGD N P +++AL G +V AGS
Sbjct: 565 EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQ 624
Query: 964 HTAVLLMDGQVFTFG 978
+ L GQV+ +G
Sbjct: 625 SSLALTSTGQVYAWG 639
Score = 58.2 bits (139), Expect = 2e-07
Identities = 37/113 (32%), Positives = 54/113 (47%), Gaps = 2/113 (1%)
Query: 876 GSGERGEKDASKITTYP-PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQL 934
G G+ G+ T P + C + +V+CG SV L ++G VYTFG + L
Sbjct: 4212 GDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGL 4271
Query: 935 GHGDVNSRGCPTLVQALPGPSTQ-VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
G + P + L G + V G+ HT L +G V+ +GS S+GQLG
Sbjct: 4272 PEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLG 4324
Score = 55.1 bits (131), Expect = 2e-06
Identities = 35/114 (30%), Positives = 61/114 (53%), Gaps = 8/114 (7%)
Query: 876 GSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFH-HSVVLMENGDVYTFGYGQHGQL 934
G G+ + K T+ P ++ V S G H++ G+V+++G G +G+L
Sbjct: 436 GLGDSNNQSTLKKLTFEPHR-----SIKKVSSSKGSDGHTLAFTTEGEVFSWGDGDYGKL 490
Query: 935 GHGDVNSRGCPTLVQA-LPGPSTQ-VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
GHG+ +++ P L+Q L G V+AG H+A + DG+++T+G G+LG
Sbjct: 491 GHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLG 544
Score = 53.9 bits (128), Expect = 4e-06
Identities = 43/141 (30%), Positives = 68/141 (48%), Gaps = 10/141 (7%)
Query: 853 EQALARLRSHPAQ--LKHKRDKHKDGSGERGE-KDASKITTYPPGSVRFDCELRAVQVSC 909
EQ ++ S P L K D + G+G G+ +A + P + F +A QV C
Sbjct: 3978 EQIMSWATSRPEDWHLGGKCDVYLWGAGRHGQLAEAGRNVMVPAAAPSFS---QAQQVIC 4034
Query: 910 GFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG---PSTQVTAGSN-HT 965
G + + V+ NG V G G +G+LG G+ + T++ AL G + GS+ H+
Sbjct: 4035 GQNCTFVIQANGTVLACGEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHS 4094
Query: 966 AVLLMDGQVFTFGSFSKGQLG 986
L G+VF++G G+LG
Sbjct: 4095 MALTESGEVFSWGDGDYGKLG 4115
Score = 51.6 bits (122), Expect = 2e-05
Identities = 26/75 (34%), Positives = 43/75 (57%), Gaps = 2/75 (2%)
Query: 906 QVSCGFHHSVVLMENGD-VYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSN 963
QV+CG +H++ + +G V+ FG G +G+LG G+ ++ P + L G +V G+
Sbjct: 4190 QVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQ 4249
Query: 964 HTAVLLMDGQVFTFG 978
+ L DG V+TFG
Sbjct: 4250 FSVALTKDGHVYTFG 4264
Score = 50.1 bits (118), Expect = 5e-05
Identities = 27/61 (44%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAGSNHT 965
V+ G H++ L NGDVY +G GQLG G N PTLV L G + Q++AG H+
Sbjct: 4296 VAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISAGRCHS 4355
Query: 966 A 966
A
Sbjct: 4356 A 4356
Score = 38.9 bits (89), Expect = 0.12
Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 8/69 (11%)
Query: 922 DVYTFGYGQHGQLGHGDVN---SRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFG 978
DVY +G G+HGQL N P+ QA QV G N T V+ +G V G
Sbjct: 3998 DVYLWGAGRHGQLAEAGRNVMVPAAAPSFSQA-----QQVICGQNCTFVIQANGTVLACG 4052
Query: 979 SFSKGQLGR 987
S G+LG+
Sbjct: 4053 EGSYGRLGQ 4061
Score = 38.5 bits (88), Expect = 0.16
Identities = 28/85 (32%), Positives = 41/85 (48%), Gaps = 6/85 (7%)
Query: 885 ASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRG- 943
+S+ T P + R V VS G H + L + +VY +G GQ G G NS G
Sbjct: 648 SSEATALRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQG--NSTGP 705
Query: 944 --CPTLVQALPGPS-TQVTAGSNHT 965
P V L G + Q++AG++H+
Sbjct: 706 ITKPKKVSGLDGIAIQQISAGTSHS 730
>gi|20127580 BTB (POZ) domain containing 2 [Homo sapiens]
Length = 525
Score = 70.5 bits (171), Expect = 4e-11
Identities = 50/160 (31%), Positives = 75/160 (46%), Gaps = 19/160 (11%)
Query: 1196 VNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFG---GRGEYTAKIKLFELGPDGG 1252
+NRF+ WGYS S + IRFS + I + G GL+G G +Y I++
Sbjct: 374 INRFQQVESRWGYSGTS-DRIRFSVNKRIFVVGFGLYGSIHGPTDYQVNIQII------- 425
Query: 1253 DHETDGDLLAETDVLAYDC-AAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQ 1311
H +L + D + C + + +MF EPV + Y A A + GP S G+ G
Sbjct: 426 -HTDSNTVLGQNDT-GFSCDGSASTFRVMFKEPVEVLPNVNYTACATLKGPDSHYGTKGL 483
Query: 1312 ASIT-----TDDGVVFQFKSSKKSNNGTDVNAGQIPQLLY 1346
+T T F F + +NNGT V GQIP++++
Sbjct: 484 RKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIF 523
Score = 47.8 bits (112), Expect = 3e-04
Identities = 47/172 (27%), Positives = 75/172 (43%), Gaps = 20/172 (11%)
Query: 1680 LHSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGG-GGIHEYELEV 1738
L + S NRF + ++ G+ D I FSV+K I VVGF +YG G +Y++ +
Sbjct: 367 LRGKECSINRFQQVESRWGYS---GTSDRIRFSVNKR-IFVVGFGLYGSIHGPTDYQVNI 422
Query: 1739 LVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNY 1798
+ H+ T L ++ D S S + + V + NV Y
Sbjct: 423 QI---------IHTDSNTVLGQNDTGFSCDGSASTF-RVMFKEPVEVLPNVNYTACATLK 472
Query: 1799 GSRTANGDGGMTTVQCPDGVT-----FTFSTCSLSSNGTNQTRGQIPQILYY 1845
G + G G+ V T FTF + ++NGT+ GQIP++++Y
Sbjct: 473 GPDSHYGTKGLRKVTHESPTTGAKTCFTFCYAAGNNNGTSVEDGQIPEVIFY 524
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 69.3 bits (168), Expect = 8e-11
Identities = 38/82 (46%), Positives = 50/82 (60%), Gaps = 2/82 (2%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG-PSTQVTAGSNHT 965
V+CG HS +L ++G ++TFG G+HGQLGH + P LV L G TQ+ G HT
Sbjct: 248 VACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHT 307
Query: 966 AVLLMD-GQVFTFGSFSKGQLG 986
+ D G+VF+FGS GQLG
Sbjct: 308 LAYVSDLGKVFSFGSGKDGQLG 329
Score = 68.2 bits (165), Expect = 2e-10
Identities = 36/99 (36%), Positives = 56/99 (56%), Gaps = 1/99 (1%)
Query: 889 TTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLV 948
+T P V + Q+S G HS+ L +G++Y++G + GQLG G S+ P+L+
Sbjct: 178 STTTPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLI 237
Query: 949 QALPGPSTQ-VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
+ L + V G +H+A+L DG +FTFG+ GQLG
Sbjct: 238 EGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLG 276
Score = 66.2 bits (160), Expect = 7e-10
Identities = 33/88 (37%), Positives = 53/88 (60%), Gaps = 2/88 (2%)
Query: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPG-PSTQV 958
E + +Q++CG +HS+ L + G+++ +G HGQLG G S P +V+ L G P Q+
Sbjct: 137 EKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQI 196
Query: 959 TAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
+AG H+ L M G ++++G GQLG
Sbjct: 197 SAGEAHSMALSMSGNIYSWGKNECGQLG 224
Score = 62.8 bits (151), Expect = 8e-09
Identities = 53/188 (28%), Positives = 88/188 (46%), Gaps = 31/188 (16%)
Query: 516 GKYQSLGIKQGGP----------SAGKWVELPITKSPKIVHFSVG-------HDGSHALL 558
G Y SL + +GG G + P T +P+IV G +H++
Sbjct: 146 GDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMA 205
Query: 559 VAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKD 618
++ G+I+ G K E G+ +SK P I ++ + V + AC S+++++D
Sbjct: 206 LSMSGNIYSWG---KNECGQLGLGHTESKD-DPSLIEGLDNQKVEFVACGGSHSALLTQD 261
Query: 619 GELYMFG--KDAIYSDSSS-------LVTDLKGHFVTQVAMGKAHTCVLMKN-GEVWTFG 668
G L+ FG K +S+ LV +L G+ VTQ+A G+ HT + + G+V++FG
Sbjct: 262 GLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFG 321
Query: 669 VNNKGQCG 676
GQ G
Sbjct: 322 SGKDGQLG 329
Score = 50.4 bits (119), Expect = 4e-05
Identities = 37/151 (24%), Positives = 66/151 (43%), Gaps = 14/151 (9%)
Query: 538 ITKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKM 597
I + KI+ + G H+L +++ G +F G G+ G R+ P+ + +
Sbjct: 134 ILQEKKIIQITCGD--YHSLALSKGGELFAWGQNLHGQLGVG---RKFPSTTTPQIVEHL 188
Query: 598 EGKIVVYTACNNGSSSVISKDGELYMFGKDAI---------YSDSSSLVTDLKGHFVTQV 648
G + + S +S G +Y +GK+ D SL+ L V V
Sbjct: 189 AGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFV 248
Query: 649 AMGKAHTCVLMKNGEVWTFGVNNKGQCGRDT 679
A G +H+ +L ++G ++TFG GQ G ++
Sbjct: 249 ACGGSHSALLTQDGLLFTFGAGKHGQLGHNS 279
Score = 38.5 bits (88), Expect = 0.16
Identities = 18/71 (25%), Positives = 39/71 (54%), Gaps = 1/71 (1%)
Query: 903 RAVQVSCGFHHSVVLMEN-GDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTAG 961
R Q++CG H++ + + G V++FG G+ GQLG+G + P V+ ++ +
Sbjct: 296 RVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESH 355
Query: 962 SNHTAVLLMDG 972
++ ++++ G
Sbjct: 356 TSEKELIMIAG 366
>gi|13376848 BTB (POZ) domain containing 1 isoform 1 [Homo sapiens]
Length = 482
Score = 68.9 bits (167), Expect = 1e-10
Identities = 48/159 (30%), Positives = 74/159 (46%), Gaps = 18/159 (11%)
Query: 1196 VNRFESHGGGWGYSAHSVEAIRFSADTDILLGGLGLFG---GRGEYTAKIKLFELGPDGG 1252
+NRF+ WGYS S + IRF+ + I + G GL+G G +Y I++ E
Sbjct: 332 INRFQQVESRWGYSGTS-DRIRFTVNRRISIVGFGLYGSIHGPTDYQVNIQIIEYEKK-- 388
Query: 1253 DHETDGDLLAETDVLAYDC-AAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHGQ 1311
L + D + C + +MF EP+ + Y A A + GP S G+ G
Sbjct: 389 ------QTLGQNDT-GFSCDGTANTFRVMFKEPIEILPNVCYTACATLKGPDSHYGTKGL 441
Query: 1312 ASITTD----DGVVFQFKSSKKSNNGTDVNAGQIPQLLY 1346
+ + VF F SS +NNGT + GQIP++++
Sbjct: 442 KKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIF 480
Score = 36.6 bits (83), Expect = 0.60
Identities = 38/171 (22%), Positives = 70/171 (40%), Gaps = 19/171 (11%)
Query: 1680 LHSVKASANRFTKTSQGRSWNTGNGSPDAICFSVDKPGIVVVGFSVYGG-GGIHEYELEV 1738
L + NRF + ++ G+ D I F+V++ I +VGF +YG G +Y++ +
Sbjct: 325 LRGKECCINRFQQVESRWGYS---GTSDRIRFTVNRR-ISIVGFGLYGSIHGPTDYQVNI 380
Query: 1739 LVDDSEHAGDSTHSHRWTSLELVKGTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNY 1798
+ + E + S + T+ + + + + NV Y
Sbjct: 381 QIIEYEKKQTLGQNDTGFSCDGTANTF----------RVMFKEPIEILPNVCYTACATLK 430
Query: 1799 GSRTANGDGGMTTV----QCPDGVTFTFSTCSLSSNGTNQTRGQIPQILYY 1845
G + G G+ V F F + ++NGT+ GQIP+I++Y
Sbjct: 431 GPDSHYGTKGLKKVVHETPAASKTVFFFFSSPGNNNGTSIEDGQIPEIIFY 481
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 68.9 bits (167), Expect = 1e-10
Identities = 36/96 (37%), Positives = 60/96 (62%), Gaps = 2/96 (2%)
Query: 893 PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQAL 951
P +++ +++ VQV+CG++HS+ L + +V+ +G ++GQLG G D + P L+++L
Sbjct: 128 PRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSL 187
Query: 952 PG-PSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
G P QV AG H+ VL + G +F +G GQLG
Sbjct: 188 LGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLG 223
Score = 62.8 bits (151), Expect = 8e-09
Identities = 51/207 (24%), Positives = 91/207 (43%), Gaps = 20/207 (9%)
Query: 497 GAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHF-SVGHDGSH 555
G AL K + + KY LG+ G K + KS + F V G+H
Sbjct: 145 GYYHSLALSKASEVFCWGQNKYGQLGL---GTDCKKQTSPQLLKSLLGIPFMQVAAGGAH 201
Query: 556 ALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVI 615
+ ++ G+IF G G+ G + ++ R Y P + + + +VY C ++ +
Sbjct: 202 SFVLTLSGAIFGWGRNKFGQLGLNDENDR----YVPNLLKSLRSQKIVYICCGEDHTAAL 257
Query: 616 SKDGELYMFG---------KDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLM-KNGEVW 665
+K+G ++ FG + + V +L G VT++A G+ HT + +G ++
Sbjct: 258 TKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIY 317
Query: 666 TFGVNNKGQCGRDTGAMNQGGKGFGVE 692
+FG+ GQ G TG+ + F V+
Sbjct: 318 SFGLGGNGQLG--TGSTSNRKSPFTVK 342
Score = 62.4 bits (150), Expect = 1e-08
Identities = 34/83 (40%), Positives = 48/83 (57%), Gaps = 1/83 (1%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSN 963
+QV+ G HS VL +G ++ +G + GQLG D N R P L+++L + G +
Sbjct: 193 MQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGED 252
Query: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
HTA L +G VFTFG+ GQLG
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLG 275
Score = 59.7 bits (143), Expect = 7e-08
Identities = 33/98 (33%), Positives = 50/98 (51%), Gaps = 2/98 (2%)
Query: 891 YPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQA 950
Y P ++ + V + CG H+ L + G V+TFG G +GQLGH + P V
Sbjct: 231 YVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFE 290
Query: 951 LPGP-STQVTAGSNHTAVLL-MDGQVFTFGSFSKGQLG 986
L G T++ G HT+ + G++++FG GQLG
Sbjct: 291 LMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328
Score = 58.5 bits (140), Expect = 1e-07
Identities = 38/95 (40%), Positives = 47/95 (49%), Gaps = 3/95 (3%)
Query: 893 PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALP 952
P F R V CG H+V ++++G VYT G GQLGH SR P V AL
Sbjct: 25 PRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH--EKSRKKPEQVVALD 82
Query: 953 GPS-TQVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
+ V+ G HT L GQV+ +G S GQLG
Sbjct: 83 AQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Score = 50.1 bits (118), Expect = 5e-05
Identities = 35/146 (23%), Positives = 68/146 (46%), Gaps = 14/146 (9%)
Query: 543 KIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIV 602
+IV + G+ H+L +++ +F G G+ G T ++Q+ P K ++ G
Sbjct: 138 QIVQVACGY--YHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL---GIPF 192
Query: 603 VYTACNNGSSSVISKDGELYMFGKDAI----YSDSS-----SLVTDLKGHFVTQVAMGKA 653
+ A S V++ G ++ +G++ +D + +L+ L+ + + G+
Sbjct: 193 MQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGED 252
Query: 654 HTCVLMKNGEVWTFGVNNKGQCGRDT 679
HT L K G V+TFG GQ G ++
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLGHNS 278
Score = 47.0 bits (110), Expect = 4e-04
Identities = 49/191 (25%), Positives = 77/191 (40%), Gaps = 16/191 (8%)
Query: 496 LGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSH 555
+G G + +G +Y G LG S K ++ + IV S G +H
Sbjct: 39 VGCGLRHTVFVLDDGTVYTCG-CNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGE--AH 95
Query: 556 ALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVI 615
L + + G ++ G S G+ G P K + ++ +V AC S +
Sbjct: 96 TLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQ---IVQVACGYYHSLAL 152
Query: 616 SKDGELYMFGK----------DAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVW 665
SK E++ +G+ D S L+ L G QVA G AH+ VL +G ++
Sbjct: 153 SKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212
Query: 666 TFGVNNKGQCG 676
+G N GQ G
Sbjct: 213 GWGRNKFGQLG 223
Score = 37.7 bits (86), Expect = 0.27
Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 1/45 (2%)
Query: 906 QVSCGFHH-SVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQ 949
+++CG H S + +G +Y+FG G +GQLG G ++R P V+
Sbjct: 298 EIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 68.9 bits (167), Expect = 1e-10
Identities = 36/96 (37%), Positives = 60/96 (62%), Gaps = 2/96 (2%)
Query: 893 PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQAL 951
P +++ +++ VQV+CG++HS+ L + +V+ +G ++GQLG G D + P L+++L
Sbjct: 128 PRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSL 187
Query: 952 PG-PSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
G P QV AG H+ VL + G +F +G GQLG
Sbjct: 188 LGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLG 223
Score = 62.8 bits (151), Expect = 8e-09
Identities = 51/207 (24%), Positives = 91/207 (43%), Gaps = 20/207 (9%)
Query: 497 GAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHF-SVGHDGSH 555
G AL K + + KY LG+ G K + KS + F V G+H
Sbjct: 145 GYYHSLALSKASEVFCWGQNKYGQLGL---GTDCKKQTSPQLLKSLLGIPFMQVAAGGAH 201
Query: 556 ALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVI 615
+ ++ G+IF G G+ G + ++ R Y P + + + +VY C ++ +
Sbjct: 202 SFVLTLSGAIFGWGRNKFGQLGLNDENDR----YVPNLLKSLRSQKIVYICCGEDHTAAL 257
Query: 616 SKDGELYMFG---------KDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLM-KNGEVW 665
+K+G ++ FG + + V +L G VT++A G+ HT + +G ++
Sbjct: 258 TKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIY 317
Query: 666 TFGVNNKGQCGRDTGAMNQGGKGFGVE 692
+FG+ GQ G TG+ + F V+
Sbjct: 318 SFGLGGNGQLG--TGSTSNRKSPFTVK 342
Score = 62.4 bits (150), Expect = 1e-08
Identities = 34/83 (40%), Positives = 48/83 (57%), Gaps = 1/83 (1%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSN 963
+QV+ G HS VL +G ++ +G + GQLG D N R P L+++L + G +
Sbjct: 193 MQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGED 252
Query: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
HTA L +G VFTFG+ GQLG
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLG 275
Score = 59.7 bits (143), Expect = 7e-08
Identities = 33/98 (33%), Positives = 50/98 (51%), Gaps = 2/98 (2%)
Query: 891 YPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQA 950
Y P ++ + V + CG H+ L + G V+TFG G +GQLGH + P V
Sbjct: 231 YVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFE 290
Query: 951 LPGP-STQVTAGSNHTAVLL-MDGQVFTFGSFSKGQLG 986
L G T++ G HT+ + G++++FG GQLG
Sbjct: 291 LMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLG 328
Score = 58.5 bits (140), Expect = 1e-07
Identities = 38/95 (40%), Positives = 47/95 (49%), Gaps = 3/95 (3%)
Query: 893 PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALP 952
P F R V CG H+V ++++G VYT G GQLGH SR P V AL
Sbjct: 25 PRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGH--EKSRKKPEQVVALD 82
Query: 953 GPS-TQVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
+ V+ G HT L GQV+ +G S GQLG
Sbjct: 83 AQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLG 117
Score = 50.1 bits (118), Expect = 5e-05
Identities = 35/146 (23%), Positives = 68/146 (46%), Gaps = 14/146 (9%)
Query: 543 KIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIV 602
+IV + G+ H+L +++ +F G G+ G T ++Q+ P K ++ G
Sbjct: 138 QIVQVACGY--YHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLL---GIPF 192
Query: 603 VYTACNNGSSSVISKDGELYMFGKDAI----YSDSS-----SLVTDLKGHFVTQVAMGKA 653
+ A S V++ G ++ +G++ +D + +L+ L+ + + G+
Sbjct: 193 MQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGED 252
Query: 654 HTCVLMKNGEVWTFGVNNKGQCGRDT 679
HT L K G V+TFG GQ G ++
Sbjct: 253 HTAALTKEGGVFTFGAGGYGQLGHNS 278
Score = 47.0 bits (110), Expect = 4e-04
Identities = 49/191 (25%), Positives = 77/191 (40%), Gaps = 16/191 (8%)
Query: 496 LGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSH 555
+G G + +G +Y G LG S K ++ + IV S G +H
Sbjct: 39 VGCGLRHTVFVLDDGTVYTCG-CNDLGQLGHEKSRKKPEQVVALDAQNIVAVSCGE--AH 95
Query: 556 ALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVI 615
L + + G ++ G S G+ G P K + ++ +V AC S +
Sbjct: 96 TLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQ---IVQVACGYYHSLAL 152
Query: 616 SKDGELYMFGK----------DAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVW 665
SK E++ +G+ D S L+ L G QVA G AH+ VL +G ++
Sbjct: 153 SKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIF 212
Query: 666 TFGVNNKGQCG 676
+G N GQ G
Sbjct: 213 GWGRNKFGQLG 223
Score = 37.7 bits (86), Expect = 0.27
Identities = 17/45 (37%), Positives = 28/45 (62%), Gaps = 1/45 (2%)
Query: 906 QVSCGFHH-SVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQ 949
+++CG H S + +G +Y+FG G +GQLG G ++R P V+
Sbjct: 298 EIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVK 342
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 68.6 bits (166), Expect = 1e-10
Identities = 46/134 (34%), Positives = 64/134 (47%), Gaps = 11/134 (8%)
Query: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAG 961
+ V +SCG H+ VL ++G V+TFG G GQLGH +N P V L G TQ+ G
Sbjct: 243 KVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACG 302
Query: 962 SNHT-AVLLMDGQVFTFGSFSKGQLGR--------PILDVPYWNAKPAPMPNIGSKYG-R 1011
HT A + G ++ FG ++GQLG P YW A + ++
Sbjct: 303 RQHTLAFVPSSGLIYAFGCGARGQLGTGHTCNVKCPSPVKGYWAAHSGQLSARADRFKYH 362
Query: 1012 KATWIGASGDQTFL 1025
I + GDQTF+
Sbjct: 363 IVKQIFSGGDQTFV 376
Score = 63.5 bits (153), Expect = 5e-09
Identities = 36/84 (42%), Positives = 49/84 (58%), Gaps = 2/84 (2%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPG-PSTQVTAGS 962
+QVSCG H + L +G +T+G HGQLG G + S+ P V++L G P QV AG
Sbjct: 140 LQVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGG 199
Query: 963 NHTAVLLMDGQVFTFGSFSKGQLG 986
H+ L + G VF +G + GQLG
Sbjct: 200 AHSFALSLSGAVFGWGMNNAGQLG 223
Score = 62.0 bits (149), Expect = 1e-08
Identities = 51/203 (25%), Positives = 94/203 (46%), Gaps = 22/203 (10%)
Query: 488 GFDEESAI--LGAGREFALMKTANGKIYYTGKYQS--LGIKQGGPSAGKWVELPITKSPK 543
GF + ++ + G ++ +G++Y G LG ++ G K ++
Sbjct: 29 GFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREG---NKPEQIGALADQH 85
Query: 544 IVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVV 603
I+H + G SH+L +++ G +F G+ S G+ G T + P+ I K+ + ++
Sbjct: 86 IIHVACGE--SHSLALSDRGQLFSWGAGSDGQLGLMTT---EDSVAVPRLIQKLNQQTIL 140
Query: 604 YTACNNGSSSVISKDGELYMFGKDA----------IYSDSSSLVTDLKGHFVTQVAMGKA 653
+C N ++ DG+ + +GK++ S V L+G + QVA G A
Sbjct: 141 QVSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGA 200
Query: 654 HTCVLMKNGEVWTFGVNNKGQCG 676
H+ L +G V+ +G+NN GQ G
Sbjct: 201 HSFALSLSGAVFGWGMNNAGQLG 223
Score = 60.5 bits (145), Expect = 4e-08
Identities = 34/82 (41%), Positives = 49/82 (59%), Gaps = 3/82 (3%)
Query: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNH 964
+V+CG +HSV L+E+G+VYT G GQLGH ++ P + AL V G +H
Sbjct: 38 EVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNK--PEQIGALADQHIIHVACGESH 95
Query: 965 TAVLLMDGQVFTFGSFSKGQLG 986
+ L GQ+F++G+ S GQLG
Sbjct: 96 SLALSDRGQLFSWGAGSDGQLG 117
Score = 60.5 bits (145), Expect = 4e-08
Identities = 49/193 (25%), Positives = 91/193 (47%), Gaps = 18/193 (9%)
Query: 496 LGAGREFALMKTANGKIYYTGK--YQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDG 553
+ G L A+G+ + GK + LG+ + PS + + + + G G
Sbjct: 142 VSCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAG--G 199
Query: 554 SHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSS 613
+H+ ++ G++F G + G+ G S + R+S P + + + VVY +C ++
Sbjct: 200 AHSFALSLSGAVFGWGMNNAGQLGLSDEKDRES----PCHVKLLRTQKVVYISCGEEHTA 255
Query: 614 VISKDGELYMFGKDA---IYSDSSS------LVTDLKGHFVTQVAMGKAHTCVLM-KNGE 663
V++K G ++ FG + + DS + V +L G VTQ+A G+ HT + +G
Sbjct: 256 VLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLELMGSEVTQIACGRQHTLAFVPSSGL 315
Query: 664 VWTFGVNNKGQCG 676
++ FG +GQ G
Sbjct: 316 IYAFGCGARGQLG 328
Score = 58.9 bits (141), Expect = 1e-07
Identities = 34/84 (40%), Positives = 48/84 (57%), Gaps = 2/84 (2%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLG-HGDVNSRGCPTLVQALPGPS-TQVTAGS 962
+ V+CG HS+ L + G ++++G G GQLG +S P L+Q L + QV+ G+
Sbjct: 87 IHVACGESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGN 146
Query: 963 NHTAVLLMDGQVFTFGSFSKGQLG 986
H L DGQ FT+G S GQLG
Sbjct: 147 WHCLALAADGQFFTWGKNSHGQLG 170
Score = 57.4 bits (137), Expect = 3e-07
Identities = 35/82 (42%), Positives = 43/82 (52%), Gaps = 1/82 (1%)
Query: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNH 964
QV+ G HS L +G V+ +G GQLG D R P V+ L ++ G H
Sbjct: 194 QVAAGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEH 253
Query: 965 TAVLLMDGQVFTFGSFSKGQLG 986
TAVL G VFTFG+ S GQLG
Sbjct: 254 TAVLTKSGGVFTFGAGSCGQLG 275
Score = 55.8 bits (133), Expect = 9e-07
Identities = 39/134 (29%), Positives = 61/134 (45%), Gaps = 12/134 (8%)
Query: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614
H L +A DG F G S G+ G + Q+ P +++ +EG + A S
Sbjct: 148 HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASP---QRVRSLEGIPLAQVAAGGAHSFA 204
Query: 615 ISKDGELYMFG---------KDAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEVW 665
+S G ++ +G D +S V L+ V ++ G+ HT VL K+G V+
Sbjct: 205 LSLSGAVFGWGMNNAGQLGLSDEKDRESPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVF 264
Query: 666 TFGVNNKGQCGRDT 679
TFG + GQ G D+
Sbjct: 265 TFGAGSCGQLGHDS 278
Score = 37.4 bits (85), Expect = 0.35
Identities = 16/34 (47%), Positives = 24/34 (70%)
Query: 645 VTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRD 678
V +VA G H+ L+++GEV+T G+N KGQ G +
Sbjct: 36 VKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHE 69
>gi|57863304 inhibitor of Bruton's tyrosine kinase [Homo sapiens]
Length = 1353
Score = 67.0 bits (162), Expect = 4e-10
Identities = 40/81 (49%), Positives = 49/81 (60%), Gaps = 2/81 (2%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAGSNHT 965
V C FH SV L + G VYT G+G G+LGHGD + P LV+ L G + +QV A +HT
Sbjct: 183 VLCKFH-SVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDHT 241
Query: 966 AVLLMDGQVFTFGSFSKGQLG 986
VL DG V+TFG QLG
Sbjct: 242 VVLTEDGCVYTFGLNIFHQLG 262
Score = 43.1 bits (100), Expect = 0.006
Identities = 40/147 (27%), Positives = 62/147 (42%), Gaps = 23/147 (15%)
Query: 922 DVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS---TQVTAGSNHTAVLLMDGQVFTFG 978
DVYT+G + LGHG NS+ P LV QV H+ L GQV+T G
Sbjct: 143 DVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIKQVVLCKFHSVFLSQKGQVYTCG 202
Query: 979 SFSKGQLGRPILDVPYWNAKPAPMPN-IGSKYGRKATWIGASGDQTFLRIDEALINSHVL 1037
G+LG + + + +P + G + + A+ D T + ++ + + L
Sbjct: 203 HGPGGRLG-------HGDEQTCLVPRLVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGL 255
Query: 1038 ATSEIFASKHIIGLVPASISEPPPFKC 1064
IF H +G++ PPP C
Sbjct: 256 ---NIF---HQLGII------PPPSSC 270
Score = 39.7 bits (91), Expect = 0.070
Identities = 21/41 (51%), Positives = 26/41 (63%)
Query: 636 LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676
LV L GH +QVA K HT VL ++G V+TFG+N Q G
Sbjct: 222 LVEGLNGHNCSQVAAAKDHTVVLTEDGCVYTFGLNIFHQLG 262
Score = 37.4 bits (85), Expect = 0.35
Identities = 36/85 (42%), Positives = 44/85 (51%), Gaps = 6/85 (7%)
Query: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLG-HGDVNSRGCPTLVQA--LPGPS-TQVTAG 961
QV+ H+VVL E+G VYTFG QLG +S P +QA L G + V AG
Sbjct: 233 QVAAAKDHTVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAG 292
Query: 962 SNHTAVLLMDGQVFTFGSFSKGQLG 986
HT VL V+T G + GQLG
Sbjct: 293 RFHT-VLWTREAVYTMG-LNGGQLG 315
>gi|225543407 BTB domain protein BDPL [Homo sapiens]
Length = 485
Score = 66.6 bits (161), Expect = 5e-10
Identities = 49/158 (31%), Positives = 77/158 (48%), Gaps = 21/158 (13%)
Query: 1197 NRFES---HGGGWGYSAHSVEAIRFSADTDILLGGLGLFG---GRGEYTAKIKLFELGPD 1250
+RF+S W Y ++I+F+ D + + GLGL+G G+ EY+ KI+L LG
Sbjct: 339 HRFQSSAYRSNQWRYRGRC-DSIQFAVDRRVFIAGLGLYGSSSGKAEYSVKIELKRLGV- 396
Query: 1251 GGDHETDGDLLAETDVLAYDCAAREKYAMMFDEPVLLQAGWWYVAWARVSGPSSDCGSHG 1310
+LA+ + + + F+ PV ++ +Y A A + G S+ G
Sbjct: 397 ---------VLAQNLTKFMSDGSSNTFPVWFEHPVQVEQDTFYTASAVLDG--SELSYFG 445
Query: 1311 QASITTDD--GVVFQFKSSKKSNNGTDVNAGQIPQLLY 1346
Q +T V FQF+ S S NGT V GQIP+L++
Sbjct: 446 QEGMTEVQCGKVAFQFQCSSDSTNGTGVQGGQIPELIF 483
Score = 43.9 bits (102), Expect = 0.004
Identities = 40/144 (27%), Positives = 64/144 (44%), Gaps = 16/144 (11%)
Query: 1704 GSPDAICFSVDKPGIVVVGFSVYGGG-GIHEYELEVLVDDSEHAGDSTHSHRWTSLELVK 1762
G D+I F+VD+ + + G +YG G EY +++ + R +
Sbjct: 355 GRCDSIQFAVDRR-VFIAGLGLYGSSSGKAEYSVKIELK------------RLGVVLAQN 401
Query: 1763 GTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTAN-GDGGMTTVQCPDGVTFT 1821
T D S+ + + V ++++ Y GS + G GMT VQC V F
Sbjct: 402 LTKFMSDGSSNTFPVWFEHPVQVEQDTFYTASAVLDGSELSYFGQEGMTEVQCGK-VAFQ 460
Query: 1822 FSTCSLSSNGTNQTRGQIPQILYY 1845
F S S+NGT GQIP++++Y
Sbjct: 461 FQCSSDSTNGTGVQGGQIPELIFY 484
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 65.9 bits (159), Expect = 9e-10
Identities = 63/203 (31%), Positives = 88/203 (43%), Gaps = 25/203 (12%)
Query: 491 EESAILGAGREFALMKTANGKIYYTGKYQS--LGIKQGGPSAGKWVELPITKSPKIVHFS 548
E+ + GR L+ T G +Y TG LG+ V T KI S
Sbjct: 87 EKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLS 146
Query: 549 VGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACN 608
G + S AL EDG +F G S+G+ G + S P+++ GK V + +C
Sbjct: 147 AGSNTSAAL--TEDGRLFMWGDNSEGQIG----LKNVSNVCVPQQVTI--GKPVSWISCG 198
Query: 609 NGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHF------------VTQVAMGKAHTC 656
S+ ++ DGELY+FG+ + L L G+ V QVA G HT
Sbjct: 199 YYHSAFVTTDGELYVFGEPE--NGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV 256
Query: 657 VLMKNGEVWTFGVNNKGQCGRDT 679
VL +N V+TFG+ GQ G T
Sbjct: 257 VLTENA-VYTFGLGQFGQLGLGT 278
Score = 62.4 bits (150), Expect = 1e-08
Identities = 39/102 (38%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 886 SKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCP 945
SK PG F ++ V +SCG HS V+ N +Y FG GQLG G ++ P
Sbjct: 20 SKFAENNPGKFWFKNDV-PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKP 78
Query: 946 TLVQALPGPSTQVTA-GSNHTAVLLMDGQVFTFGSFSKGQLG 986
T V+AL ++ A G NHT V G V+ G ++GQLG
Sbjct: 79 TCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
Score = 62.4 bits (150), Expect = 1e-08
Identities = 35/86 (40%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPS-TQVTA 960
+ +QV+CG H+VVL EN VYTFG GQ GQLG G + P +++ + + + ++
Sbjct: 244 KVIQVACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISC 302
Query: 961 GSNHTAVLLMDGQVFTFGSFSKGQLG 986
G NHTA++ G ++TFG G+LG
Sbjct: 303 GENHTALITDIGLMYTFGDGRHGKLG 328
Score = 59.3 bits (142), Expect = 9e-08
Identities = 31/82 (37%), Positives = 48/82 (58%), Gaps = 3/82 (3%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD--VNSRGCPTLVQALPGPSTQVTAGSNH 964
+SCG++HS + +G++Y FG ++G+LG + + + P LV +P QV G H
Sbjct: 195 ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEH 254
Query: 965 TAVLLMDGQVFTFGSFSKGQLG 986
T V+L + V+TFG GQLG
Sbjct: 255 T-VVLTENAVYTFGLGQFGQLG 275
Score = 58.5 bits (140), Expect = 1e-07
Identities = 31/81 (38%), Positives = 46/81 (56%), Gaps = 2/81 (2%)
Query: 908 SCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS--TQVTAGSNHT 965
+CG +H++V E G+VY G GQLG GD R ++ Q++AGSN +
Sbjct: 93 ACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTS 152
Query: 966 AVLLMDGQVFTFGSFSKGQLG 986
A L DG++F +G S+GQ+G
Sbjct: 153 AALTEDGRLFMWGDNSEGQIG 173
Score = 52.0 bits (123), Expect = 1e-05
Identities = 38/156 (24%), Positives = 74/156 (47%), Gaps = 12/156 (7%)
Query: 876 GSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLG 935
G G+ E++ + ++ F E + Q+S G + S L E+G ++ +G GQ+G
Sbjct: 120 GLGDTEERNTFHVISF------FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIG 173
Query: 936 HGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYW 995
+V++ P V + P + ++ G H+A + DG+++ FG G+LG P +
Sbjct: 174 LKNVSNVCVPQQV-TIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP--NQLLG 230
Query: 996 NAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEAL 1031
N + P + S+ K + G+ T + + A+
Sbjct: 231 NHR---TPQLVSEIPEKVIQVACGGEHTVVLTENAV 263
Score = 44.3 bits (103), Expect = 0.003
Identities = 28/85 (32%), Positives = 45/85 (52%), Gaps = 9/85 (10%)
Query: 601 IVVYTACNNGSSSVISKDGELYMFGKD-----AIYSDSS----SLVTDLKGHFVTQVAMG 651
+ V+ +C + S+V++ + +LYMFG + + S S+ + V LK V A G
Sbjct: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
Query: 652 KAHTCVLMKNGEVWTFGVNNKGQCG 676
+ HT V + G V+ G NN+GQ G
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLG 120
Score = 42.7 bits (99), Expect = 0.008
Identities = 44/214 (20%), Positives = 87/214 (40%), Gaps = 28/214 (13%)
Query: 473 ISLFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGK 532
IS F E + +S G + +A+ GR F + G+I G+K +
Sbjct: 133 ISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI---------GLKN---VSNV 180
Query: 533 WVELPITKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPK 592
V +T + S G+ H+ V DG ++ G G+ G + + P+
Sbjct: 181 CVPQQVTIGKPVSWISCGY--YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRT--PQ 236
Query: 593 KIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAI----------YSDSSSLVTDLKG 642
+ ++ K V+ AC G +V+ + +Y FG + ++ +++
Sbjct: 237 LVSEIPEK-VIQVACG-GEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRD 294
Query: 643 HFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676
++ ++ G+ HT ++ G ++TFG G+ G
Sbjct: 295 QTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
Score = 38.9 bits (89), Expect = 0.12
Identities = 15/31 (48%), Positives = 24/31 (77%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHG 937
+SCG +H+ ++ + G +YTFG G+HG+LG G
Sbjct: 300 ISCGENHTALITDIGLMYTFGDGRHGKLGLG 330
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 65.9 bits (159), Expect = 9e-10
Identities = 63/203 (31%), Positives = 88/203 (43%), Gaps = 25/203 (12%)
Query: 491 EESAILGAGREFALMKTANGKIYYTGKYQS--LGIKQGGPSAGKWVELPITKSPKIVHFS 548
E+ + GR L+ T G +Y TG LG+ V T KI S
Sbjct: 87 EKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLS 146
Query: 549 VGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACN 608
G + S AL EDG +F G S+G+ G + S P+++ GK V + +C
Sbjct: 147 AGSNTSAAL--TEDGRLFMWGDNSEGQIG----LKNVSNVCVPQQVTI--GKPVSWISCG 198
Query: 609 NGSSSVISKDGELYMFGKDAIYSDSSSLVTDLKGHF------------VTQVAMGKAHTC 656
S+ ++ DGELY+FG+ + L L G+ V QVA G HT
Sbjct: 199 YYHSAFVTTDGELYVFGEPE--NGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEHTV 256
Query: 657 VLMKNGEVWTFGVNNKGQCGRDT 679
VL +N V+TFG+ GQ G T
Sbjct: 257 VLTENA-VYTFGLGQFGQLGLGT 278
Score = 62.4 bits (150), Expect = 1e-08
Identities = 39/102 (38%), Positives = 52/102 (50%), Gaps = 2/102 (1%)
Query: 886 SKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCP 945
SK PG F ++ V +SCG HS V+ N +Y FG GQLG G ++ P
Sbjct: 20 SKFAENNPGKFWFKNDV-PVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKP 78
Query: 946 TLVQALPGPSTQVTA-GSNHTAVLLMDGQVFTFGSFSKGQLG 986
T V+AL ++ A G NHT V G V+ G ++GQLG
Sbjct: 79 TCVKALKPEKVKLAACGRNHTLVSTEGGNVYATGGNNEGQLG 120
Score = 62.4 bits (150), Expect = 1e-08
Identities = 35/86 (40%), Positives = 53/86 (61%), Gaps = 3/86 (3%)
Query: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPS-TQVTA 960
+ +QV+CG H+VVL EN VYTFG GQ GQLG G + P +++ + + + ++
Sbjct: 244 KVIQVACGGEHTVVLTENA-VYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISC 302
Query: 961 GSNHTAVLLMDGQVFTFGSFSKGQLG 986
G NHTA++ G ++TFG G+LG
Sbjct: 303 GENHTALITDIGLMYTFGDGRHGKLG 328
Score = 59.3 bits (142), Expect = 9e-08
Identities = 31/82 (37%), Positives = 48/82 (58%), Gaps = 3/82 (3%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD--VNSRGCPTLVQALPGPSTQVTAGSNH 964
+SCG++HS + +G++Y FG ++G+LG + + + P LV +P QV G H
Sbjct: 195 ISCGYYHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSEIPEKVIQVACGGEH 254
Query: 965 TAVLLMDGQVFTFGSFSKGQLG 986
T V+L + V+TFG GQLG
Sbjct: 255 T-VVLTENAVYTFGLGQFGQLG 275
Score = 58.5 bits (140), Expect = 1e-07
Identities = 31/81 (38%), Positives = 46/81 (56%), Gaps = 2/81 (2%)
Query: 908 SCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS--TQVTAGSNHT 965
+CG +H++V E G+VY G GQLG GD R ++ Q++AGSN +
Sbjct: 93 ACGRNHTLVSTEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTS 152
Query: 966 AVLLMDGQVFTFGSFSKGQLG 986
A L DG++F +G S+GQ+G
Sbjct: 153 AALTEDGRLFMWGDNSEGQIG 173
Score = 52.0 bits (123), Expect = 1e-05
Identities = 38/156 (24%), Positives = 74/156 (47%), Gaps = 12/156 (7%)
Query: 876 GSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLG 935
G G+ E++ + ++ F E + Q+S G + S L E+G ++ +G GQ+G
Sbjct: 120 GLGDTEERNTFHVISF------FTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQIG 173
Query: 936 HGDVNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYW 995
+V++ P V + P + ++ G H+A + DG+++ FG G+LG P +
Sbjct: 174 LKNVSNVCVPQQV-TIGKPVSWISCGYYHSAFVTTDGELYVFGEPENGKLGLP--NQLLG 230
Query: 996 NAKPAPMPNIGSKYGRKATWIGASGDQTFLRIDEAL 1031
N + P + S+ K + G+ T + + A+
Sbjct: 231 NHR---TPQLVSEIPEKVIQVACGGEHTVVLTENAV 263
Score = 44.3 bits (103), Expect = 0.003
Identities = 28/85 (32%), Positives = 45/85 (52%), Gaps = 9/85 (10%)
Query: 601 IVVYTACNNGSSSVISKDGELYMFGKD-----AIYSDSS----SLVTDLKGHFVTQVAMG 651
+ V+ +C + S+V++ + +LYMFG + + S S+ + V LK V A G
Sbjct: 36 VPVHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACG 95
Query: 652 KAHTCVLMKNGEVWTFGVNNKGQCG 676
+ HT V + G V+ G NN+GQ G
Sbjct: 96 RNHTLVSTEGGNVYATGGNNEGQLG 120
Score = 42.7 bits (99), Expect = 0.008
Identities = 44/214 (20%), Positives = 87/214 (40%), Gaps = 28/214 (13%)
Query: 473 ISLFDLEKDLHIISTGFDEESAILGAGREFALMKTANGKIYYTGKYQSLGIKQGGPSAGK 532
IS F E + +S G + +A+ GR F + G+I G+K +
Sbjct: 133 ISFFTSEHKIKQLSAGSNTSAALTEDGRLFMWGDNSEGQI---------GLKN---VSNV 180
Query: 533 WVELPITKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPK 592
V +T + S G+ H+ V DG ++ G G+ G + + P+
Sbjct: 181 CVPQQVTIGKPVSWISCGY--YHSAFVTTDGELYVFGEPENGKLGLPNQLLGNHRT--PQ 236
Query: 593 KIIKMEGKIVVYTACNNGSSSVISKDGELYMFGKDAI----------YSDSSSLVTDLKG 642
+ ++ K V+ AC G +V+ + +Y FG + ++ +++
Sbjct: 237 LVSEIPEK-VIQVACG-GEHTVVLTENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRD 294
Query: 643 HFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCG 676
++ ++ G+ HT ++ G ++TFG G+ G
Sbjct: 295 QTISYISCGENHTALITDIGLMYTFGDGRHGKLG 328
Score = 38.9 bits (89), Expect = 0.12
Identities = 15/31 (48%), Positives = 24/31 (77%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHG 937
+SCG +H+ ++ + G +YTFG G+HG+LG G
Sbjct: 300 ISCGENHTALITDIGLMYTFGDGRHGKLGLG 330
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 65.1 bits (157), Expect = 2e-09
Identities = 57/192 (29%), Positives = 85/192 (44%), Gaps = 18/192 (9%)
Query: 499 GREFALMKTANGKIYYTGKYQS--LGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSHA 556
G + TA+GK+Y TG LGI G S L + I +V G H
Sbjct: 3993 GEQTLFAVTADGKLYATGYGAGGRLGI-GGTESVSTPTLLESIQHVFIKKVAVNSGGKHC 4051
Query: 557 LLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVIS 616
L ++ +G ++ G A G+ G +S +P+ I + G VV A S+ ++
Sbjct: 4052 LALSSEGEVYSWGEAEDGKLGHGNRSPCD----RPRVIESLRGIEVVDVAAGGAHSACVT 4107
Query: 617 KDGELYMFGKDAI----YSDSS-----SLVTDLKGHFVTQVAMGK--AHTCVLMKNGEVW 665
G+LY +GK +SDS LV L+GH V +A G A T L + VW
Sbjct: 4108 AAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVW 4167
Query: 666 TFGVNNKGQCGR 677
++G + G+ GR
Sbjct: 4168 SWGDGDYGKLGR 4179
Score = 64.7 bits (156), Expect = 2e-09
Identities = 40/108 (37%), Positives = 54/108 (50%), Gaps = 5/108 (4%)
Query: 880 RGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDV 939
RG D K+ P + L V+V CG SV L ++G VYT+G G + +LGHG
Sbjct: 4179 RGGSDGCKV----PMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSD 4234
Query: 940 NSRGCPTLVQALPGPST-QVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
+ P VQ L G + GS H DG+V+T+G +GQLG
Sbjct: 4235 DHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLG 4282
Score = 64.3 bits (155), Expect = 3e-09
Identities = 50/153 (32%), Positives = 72/153 (47%), Gaps = 21/153 (13%)
Query: 541 SPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKII----- 595
S IV + DG H L +A G ++ G G G + P + K+I
Sbjct: 492 SRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHG-----DTVPLEEPKVISAFSG 546
Query: 596 KMEGKIVVYTACNNGSSSVISKDGELYMFGK---DAIYSDSSS------LVTDLKGHFVT 646
K GK VV+ AC + S+ I+ +GELY +G+ + SS LV LKG V
Sbjct: 547 KQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVI 606
Query: 647 QVAMGK--AHTCVLMKNGEVWTFGVNNKGQCGR 677
VA G A T + +NG+VW++G + G+ GR
Sbjct: 607 DVACGSGDAQTLAVTENGQVWSWGDGDYGKLGR 639
Score = 63.9 bits (154), Expect = 3e-09
Identities = 35/88 (39%), Positives = 52/88 (59%), Gaps = 3/88 (3%)
Query: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAG 961
R ++CG HS L +G++YT+G G++G+LGHGD ++ P +V+ L G QV G
Sbjct: 3100 RIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACG 3159
Query: 962 SN--HTAVLLMDGQVFTFGSFSKGQLGR 987
S T L +G VF++G G+LGR
Sbjct: 3160 SRDAQTLALTDEGLVFSWGDGDFGKLGR 3187
Score = 58.5 bits (140), Expect = 1e-07
Identities = 49/192 (25%), Positives = 86/192 (44%), Gaps = 20/192 (10%)
Query: 496 LGAGREFALMKTANGKIYYTGK--YQSLGIKQGGPSAGKWVELPIT--KSPKIVHFSVGH 551
+ G ++ TA G++Y G+ Y LG G S + + + + K K++ + G
Sbjct: 556 IACGSTYSAAITAEGELYTWGRGNYGRLG---HGSSEDEAIPMLVAGLKGLKVIDVACGS 612
Query: 552 DGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGS 611
+ L V E+G ++ G G+ G ++ PK I K++ VV C +
Sbjct: 613 GDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKT----PKLIEKLQDLDVVKVRCGSQF 668
Query: 612 SSVISKDGELYMFGK---------DAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNG 662
S ++KDG++Y +GK + L+ L+G V VA G H L ++
Sbjct: 669 SIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDS 728
Query: 663 EVWTFGVNNKGQ 674
EV ++G N++ Q
Sbjct: 729 EVHSWGSNDQCQ 740
Score = 58.2 bits (139), Expect = 2e-07
Identities = 31/86 (36%), Positives = 46/86 (53%), Gaps = 3/86 (3%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAGSN 963
V ++CG +S + G++YT+G G +G+LGHG P LV L G V GS
Sbjct: 554 VHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVAGLKGLKVIDVACGSG 613
Query: 964 --HTAVLLMDGQVFTFGSFSKGQLGR 987
T + +GQV+++G G+LGR
Sbjct: 614 DAQTLAVTENGQVWSWGDGDYGKLGR 639
Score = 57.8 bits (138), Expect = 2e-07
Identities = 35/110 (31%), Positives = 56/110 (50%), Gaps = 4/110 (3%)
Query: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVT 959
+L V+V CG S+ L ++G VY++G G + +LGHG P L++ L G V
Sbjct: 656 DLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVA 715
Query: 960 AGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKY 1009
AGS H L D +V ++GS + Q + +PA +P + +K+
Sbjct: 716 AGSTHCLALTEDSEVHSWGSNDQCQ---HFDTLRVTKPEPAALPGLDTKH 762
Score = 57.8 bits (138), Expect = 2e-07
Identities = 52/197 (26%), Positives = 86/197 (43%), Gaps = 21/197 (10%)
Query: 496 LGAGREFALMKTANGKIYYTGKYQS----LGIKQGGPSAGKWVELPITKSPKIVHFSVGH 551
+ G + T GK+Y G+ + LGI G + ++ S + +V
Sbjct: 2997 VAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPR--QITALSSYVVKKVAVHS 3054
Query: 552 DGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGS 611
G HA + DG +F G G+ G ++ KP+ I ++ K + AC +
Sbjct: 3055 GGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCD----KPRLIEALKTKRIRDIACGSSH 3110
Query: 612 SSVISKDGELYMFGKDAI----YSDSSS-----LVTDLKGHFVTQVAMGK--AHTCVLMK 660
S+ ++ GELY +G + D+++ +V L GH V QVA G A T L
Sbjct: 3111 SAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTD 3170
Query: 661 NGEVWTFGVNNKGQCGR 677
G V+++G + G+ GR
Sbjct: 3171 EGLVFSWGDGDFGKLGR 3187
Score = 56.2 bits (134), Expect = 7e-07
Identities = 39/117 (33%), Positives = 55/117 (47%), Gaps = 10/117 (8%)
Query: 874 KDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQ 933
K G G R D ++ G + V V+ G HS + GD+YT+G G++G+
Sbjct: 4070 KLGHGNRSPCDRPRVIESLRG-------IEVVDVAAGGAHSACVTAAGDLYTWGKGRYGR 4122
Query: 934 LGHGDVNSRGCPTLVQALPGPSTQVTA---GSNHTAVLLMDGQVFTFGSFSKGQLGR 987
LGH D + P LV+AL G A G T L D V+++G G+LGR
Sbjct: 4123 LGHSDSEDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGR 4179
Score = 55.5 bits (132), Expect = 1e-06
Identities = 44/133 (33%), Positives = 65/133 (48%), Gaps = 9/133 (6%)
Query: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG-DVNSRGCPTLVQALPGPS-TQVTAGSN 963
Q+ CG S+ L ++G V+T+G G + +LGHG DV+ R P +V+ L G V G+
Sbjct: 3209 QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRK-PQVVEGLRGKKIVHVAVGAL 3267
Query: 964 HTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNI-GSKYGRKATWIGASGDQ 1022
H + GQV+ +G GQ G V N KP + + G K R A G+S
Sbjct: 3268 HCLAVTDSGQVYAWGDNDHGQQGNGTTTV---NRKPTLVQGLEGQKITRVA--CGSSHSV 3322
Query: 1023 TFLRIDEALINSH 1035
+ +D A + H
Sbjct: 3323 AWTTVDVATPSVH 3335
Score = 55.5 bits (132), Expect = 1e-06
Identities = 53/196 (27%), Positives = 83/196 (42%), Gaps = 18/196 (9%)
Query: 496 LGAGREFALMKTANGKIYYTGK--YQSLGIKQGGPSAG-KWVELPITKSPKIVHFSVGHD 552
+ AG + TA G +Y GK Y LG K VE + ++V + G
Sbjct: 4096 VAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEA--LQGHRVVDIACGSG 4153
Query: 553 GSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSS 612
+ L + +D +++ G G+ G + P KI + G VV C + S
Sbjct: 4154 DAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKV----PMKIDSLTGLGVVKVECGSQFS 4209
Query: 613 SVISKDGELYMFGKDAIY-----SDSS----SLVTDLKGHFVTQVAMGKAHTCVLMKNGE 663
++K G +Y +GK + SD V L+G V +A G H ++GE
Sbjct: 4210 VALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATGSLHCVCCTEDGE 4269
Query: 664 VWTFGVNNKGQCGRDT 679
V+T+G N++GQ G T
Sbjct: 4270 VYTWGDNDEGQLGDGT 4285
Score = 55.1 bits (131), Expect = 2e-06
Identities = 26/80 (32%), Positives = 44/80 (55%), Gaps = 5/80 (6%)
Query: 912 HHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-----TQVTAGSNHTA 966
HH + L G+VY++G G G+LGHGD P ++ A G + GS ++A
Sbjct: 505 HHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSA 564
Query: 967 VLLMDGQVFTFGSFSKGQLG 986
+ +G+++T+G + G+LG
Sbjct: 565 AITAEGELYTWGRGNYGRLG 584
Score = 55.1 bits (131), Expect = 2e-06
Identities = 28/86 (32%), Positives = 49/86 (56%), Gaps = 1/86 (1%)
Query: 902 LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG-PSTQVTA 960
++ V V+ G H + L G+VY++G + G+LGHG+ + P ++++L G V A
Sbjct: 4039 IKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIESLRGIEVVDVAA 4098
Query: 961 GSNHTAVLLMDGQVFTFGSFSKGQLG 986
G H+A + G ++T+G G+LG
Sbjct: 4099 GGAHSACVTAAGDLYTWGKGRYGRLG 4124
Score = 53.1 bits (126), Expect = 6e-06
Identities = 42/200 (21%), Positives = 84/200 (42%), Gaps = 16/200 (8%)
Query: 496 LGAGREFALMKTANGKIYY--TGKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDG 553
+ G + T++G++Y G+Y LG K + + +++ + G
Sbjct: 3104 IACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQL-KPKMVKVLLGHRVIQVACGSRD 3162
Query: 554 SHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSS 613
+ L + ++G +F G G+ G P+ I ++ G+ V C S
Sbjct: 3163 AQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNI----PQNIERLNGQGVCQIECGAQFSL 3218
Query: 614 VISKDGELYMFGK---------DAIYSDSSSLVTDLKGHFVTQVAMGKAHTCVLMKNGEV 664
++K G ++ +GK ++ +V L+G + VA+G H + +G+V
Sbjct: 3219 ALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQV 3278
Query: 665 WTFGVNNKGQCGRDTGAMNQ 684
+ +G N+ GQ G T +N+
Sbjct: 3279 YAWGDNDHGQQGNGTTTVNR 3298
Score = 52.4 bits (124), Expect = 1e-05
Identities = 28/86 (32%), Positives = 48/86 (55%), Gaps = 1/86 (1%)
Query: 902 LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQ-VTA 960
++ V V G H+ L +G V+++G G G+LGH + P L++AL + +
Sbjct: 3047 VKKVAVHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTKRIRDIAC 3106
Query: 961 GSNHTAVLLMDGQVFTFGSFSKGQLG 986
GS+H+A L G+++T+G G+LG
Sbjct: 3107 GSSHSAALTSSGELYTWGLGEYGRLG 3132
Score = 51.6 bits (122), Expect = 2e-05
Identities = 76/302 (25%), Positives = 117/302 (38%), Gaps = 42/302 (13%)
Query: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAG 961
+ V V+ G H + + ++G VY +G HGQ G+G PTLVQ L G T+V G
Sbjct: 3258 KIVHVAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKITRVACG 3317
Query: 962 SNH----TAVLLMDGQVFTFGSF--SKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATW 1015
S+H T V + V F ++ LG L VP A I K
Sbjct: 3318 SSHSVAWTTVDVATPSVHEPVLFQTARDPLGASYLGVPSDADSSAASNKISGASNSKPN- 3376
Query: 1016 IGASGDQTFLRIDEALIN----SHVLATSEI-FASKHIIG-LVPASISEPPPFKCLLINK 1069
S + L +D L SH+L +I +A ++G L+PA++ P
Sbjct: 3377 -RPSLAKILLSLDGNLAKQQALSHILTALQIMYARDAVVGALMPAAMIAPV--------- 3426
Query: 1070 VDGSCKTFNDSEQEDLQGFGVCLDPVYDVIWRFRPNTRELWCYNAVVADARLPSAADMQS 1129
C +F+ + D + N E C AV + RL S Q
Sbjct: 3427 ---ECPSFSSAAPSDASAMASPM------------NGEE--CMLAVDIEDRL-SPNPWQE 3468
Query: 1130 RCSILSPELALPTGSRALTTRSHAALHILGCLDTLAAMQDLKMGVASTEEETQAVMKVYS 1189
+ I+S E A+ + + S +A + D L A + + T+E+ ++ K
Sbjct: 3469 KREIVSSEDAVTPSAVTPSAPSASARPFIPVTDDLGAASIIAETMTKTKEDVESQNKAAG 3528
Query: 1190 KE 1191
E
Sbjct: 3529 PE 3530
Score = 51.2 bits (121), Expect = 2e-05
Identities = 37/135 (27%), Positives = 59/135 (43%), Gaps = 20/135 (14%)
Query: 878 GERGEKDASKITTYPPGSVRFDCE----LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQ 933
G+ G + +K+ P CE LR VQ+ G + +G +Y GYG G+
Sbjct: 3963 GQLGGIEGAKVKVPTP------CEALATLRPVQLIGGEQTLFAVTADGKLYATGYGAGGR 4016
Query: 934 LGHGDVNSRGCPTLVQALPG---PSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGRPIL 990
LG G S PTL++++ V +G H L +G+V+++G G+LG
Sbjct: 4017 LGIGGTESVSTPTLLESIQHVFIKKVAVNSGGKHCLALSSEGEVYSWGEAEDGKLG---- 4072
Query: 991 DVPYWNAKPAPMPNI 1005
+ N P P +
Sbjct: 4073 ---HGNRSPCDRPRV 4084
Score = 50.4 bits (119), Expect = 4e-05
Identities = 28/88 (31%), Positives = 48/88 (54%), Gaps = 3/88 (3%)
Query: 902 LRAVQVSCGFH--HSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG-PSTQV 958
L+ + V+CG ++ + ENG V+++G G +G+LG G + P L++ L +V
Sbjct: 603 LKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDLDVVKV 662
Query: 959 TAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
GS + L DGQV+++G +LG
Sbjct: 663 RCGSQFSIALTKDGQVYSWGKGDNQRLG 690
Score = 49.7 bits (117), Expect = 7e-05
Identities = 38/130 (29%), Positives = 58/130 (44%), Gaps = 4/130 (3%)
Query: 861 SHPAQLKHKRDKHKDGSGERGEKDASKITTY-PPGSVRFDCELRAVQVSCGFH--HSVVL 917
SH A L + + G GE G TT P V+ R +QV+CG ++ L
Sbjct: 3109 SHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGSRDAQTLAL 3168
Query: 918 MENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAGSNHTAVLLMDGQVFT 976
+ G V+++G G G+LG G P ++ L G Q+ G+ + L G V+T
Sbjct: 3169 TDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSLALTKSGVVWT 3228
Query: 977 FGSFSKGQLG 986
+G +LG
Sbjct: 3229 WGKGDYFRLG 3238
Score = 48.1 bits (113), Expect = 2e-04
Identities = 26/64 (40%), Positives = 35/64 (54%), Gaps = 1/64 (1%)
Query: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAG 961
+ + ++ G H V E+G+VYT+G GQLG G N+ P LV AL G +V G
Sbjct: 4250 KVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTNAIQRPRLVAALQGKKVNRVACG 4309
Query: 962 SNHT 965
S HT
Sbjct: 4310 SAHT 4313
Score = 41.6 bits (96), Expect = 0.019
Identities = 25/87 (28%), Positives = 44/87 (50%), Gaps = 3/87 (3%)
Query: 903 RAVQVSCGFH--HSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVT 959
R V ++CG ++ L ++ V+++G G +G+LG G + P + +L G +V
Sbjct: 4144 RVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVE 4203
Query: 960 AGSNHTAVLLMDGQVFTFGSFSKGQLG 986
GS + L G V+T+G +LG
Sbjct: 4204 CGSQFSVALTKSGAVYTWGKGDYHRLG 4230
Score = 41.2 bits (95), Expect = 0.024
Identities = 28/90 (31%), Positives = 42/90 (46%), Gaps = 6/90 (6%)
Query: 902 LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCP-----TLVQALPGPST 956
L VQV+ G + G VY G +G+LG G ++S P T + +
Sbjct: 2992 LNVVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLG-ISSGTVPIPRQITALSSYVVKKV 3050
Query: 957 QVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
V +G H L +DG+VF++G G+LG
Sbjct: 3051 AVHSGGRHATALTVDGKVFSWGEGDDGKLG 3080
Score = 34.7 bits (78), Expect = 2.3
Identities = 35/149 (23%), Positives = 63/149 (42%), Gaps = 16/149 (10%)
Query: 516 GKYQSLGIKQGGPSAGKWVELPITKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGE 575
G Y LG G S G V + I + V ++ + + G+++ G
Sbjct: 4172 GDYGKLG---RGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHR 4228
Query: 576 DGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGK--DAIYSDS 633
G + + +P+++ ++GK V+ A + ++DGE+Y +G + D
Sbjct: 4229 LGHGSDDHVR----RPRQVQGLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDG 4284
Query: 634 SS-------LVTDLKGHFVTQVAMGKAHT 655
++ LV L+G V +VA G AHT
Sbjct: 4285 TTNAIQRPRLVAALQGKKVNRVACGSAHT 4313
Score = 32.7 bits (73), Expect = 8.6
Identities = 36/115 (31%), Positives = 47/115 (40%), Gaps = 6/115 (5%)
Query: 1979 SSHYAVIESEHPYKPACVMHYKVTFPECVRWMTIEFDPQCGTAQSEDVLRLLIPVRTVQN 2038
SS V+ES HPY V P + +EFD QC T + D L ++ V + +
Sbjct: 3608 SSQPVVVESSHPYTDDTSTSGTVKIPGA-EGLRVEFDRQCSTERRHDPLTVMDGVNRIVS 3666
Query: 2039 SGYGPKLTSVHENLN-SWIELK-KF--SGS-SGWPTMVLVLPGNEALFSLETASD 2088
G + + L ELK KF GS +GW V P A E SD
Sbjct: 3667 VRSGREWSDWSSELRIPGDELKWKFISDGSVNGWGWRFTVYPIMPAAGPKELLSD 3721
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 64.7 bits (156), Expect = 2e-09
Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 11/123 (8%)
Query: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG-PSTQVT 959
ELRA Q+ G H+++L G V+++G G+HGQLGHG + + P L++AL G +V
Sbjct: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
Query: 960 AGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGAS 1019
AG H+ + G ++ +G GQL P + + G R+AT +
Sbjct: 217 AGGWHSVCVSETGDIYIWGWNESGQLALPTRN----------LAEDGETVAREATELNED 266
Query: 1020 GDQ 1022
G Q
Sbjct: 267 GSQ 269
Score = 52.4 bits (124), Expect = 1e-05
Identities = 24/57 (42%), Positives = 34/57 (59%)
Query: 904 AVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA 960
AV+ SCG H+ V+ G++YT+G+G++GQLGH D S P V+ QV A
Sbjct: 302 AVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKA 358
Score = 35.4 bits (80), Expect = 1.3
Identities = 34/171 (19%), Positives = 62/171 (36%), Gaps = 51/171 (29%)
Query: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614
HALL+ G +F G G+ G T +P+ + ++G ++ A S
Sbjct: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAE----LEPRLLEALQGLVMAEVAAGGWHSVC 224
Query: 615 ISKDGELYMFGKDA------------------------IYSDSSSL-------------- 636
+S+ G++Y++G + + D S +
Sbjct: 225 VSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPF 284
Query: 637 --------VTDLK-GHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRD 678
+ DL G + + G HT V+ + GE++T+G GQ G +
Sbjct: 285 IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
Score = 33.1 bits (74), Expect = 6.6
Identities = 19/66 (28%), Positives = 35/66 (53%), Gaps = 2/66 (3%)
Query: 636 LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMA 695
L+ L+G + +VA G H+ + + G+++ +G N GQ T + + G+ V A
Sbjct: 203 LLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGE--TVAREA 260
Query: 696 TAMDED 701
T ++ED
Sbjct: 261 TELNED 266
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 64.7 bits (156), Expect = 2e-09
Identities = 40/123 (32%), Positives = 62/123 (50%), Gaps = 11/123 (8%)
Query: 901 ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG-PSTQVT 959
ELRA Q+ G H+++L G V+++G G+HGQLGHG + + P L++AL G +V
Sbjct: 157 ELRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVA 216
Query: 960 AGSNHTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGAS 1019
AG H+ + G ++ +G GQL P + + G R+AT +
Sbjct: 217 AGGWHSVCVSETGDIYIWGWNESGQLALPTRN----------LAEDGETVAREATELNED 266
Query: 1020 GDQ 1022
G Q
Sbjct: 267 GSQ 269
Score = 52.4 bits (124), Expect = 1e-05
Identities = 24/57 (42%), Positives = 34/57 (59%)
Query: 904 AVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA 960
AV+ SCG H+ V+ G++YT+G+G++GQLGH D S P V+ QV A
Sbjct: 302 AVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQLQVKA 358
Score = 35.4 bits (80), Expect = 1.3
Identities = 34/171 (19%), Positives = 62/171 (36%), Gaps = 51/171 (29%)
Query: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614
HALL+ G +F G G+ G T +P+ + ++G ++ A S
Sbjct: 169 HALLLDAAGQVFSWGGGRHGQLGHGTLEAE----LEPRLLEALQGLVMAEVAAGGWHSVC 224
Query: 615 ISKDGELYMFGKDA------------------------IYSDSSSL-------------- 636
+S+ G++Y++G + + D S +
Sbjct: 225 VSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGAPAPF 284
Query: 637 --------VTDLK-GHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRD 678
+ DL G + + G HT V+ + GE++T+G GQ G +
Sbjct: 285 IAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHE 335
Score = 33.1 bits (74), Expect = 6.6
Identities = 19/66 (28%), Positives = 35/66 (53%), Gaps = 2/66 (3%)
Query: 636 LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMA 695
L+ L+G + +VA G H+ + + G+++ +G N GQ T + + G+ V A
Sbjct: 203 LLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQLALPTRNLAEDGE--TVAREA 260
Query: 696 TAMDED 701
T ++ED
Sbjct: 261 TELNED 266
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 62.8 bits (151), Expect = 8e-09
Identities = 34/83 (40%), Positives = 50/83 (60%), Gaps = 1/83 (1%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQ-VTAGSN 963
V ++CG + +++ G+VY +GY +GQLG G+ ++ P V AL G Q V G
Sbjct: 208 VTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYA 267
Query: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
HT VL +GQV+ +G+ S GQLG
Sbjct: 268 HTLVLTDEGQVYAWGANSYGQLG 290
Score = 57.0 bits (136), Expect = 4e-07
Identities = 39/135 (28%), Positives = 64/135 (47%), Gaps = 20/135 (14%)
Query: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614
H+L++ DG +F G + G+ G + ++P + ++ K+VV AC
Sbjct: 163 HSLVLTSDGEVFAWGYNNSGQVGSGSTV---NQPIPRRVTGCLQNKVVVTIACGQMCCMA 219
Query: 615 ISKDGELYMFGKDAIYSDSSSL-------------VTDLKGHFVTQVAMGKAHTCVLMKN 661
+ GE+Y++G Y+ + L V L+G V +VA G AHT VL
Sbjct: 220 VVDTGEVYVWG----YNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDE 275
Query: 662 GEVWTFGVNNKGQCG 676
G+V+ +G N+ GQ G
Sbjct: 276 GQVYAWGANSYGQLG 290
Score = 51.6 bits (122), Expect = 2e-05
Identities = 27/86 (31%), Positives = 45/86 (52%), Gaps = 2/86 (2%)
Query: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVT--A 960
+ ++V+CG +HS+VL +G+V+ +GY GQ+G G ++ P V VT
Sbjct: 153 QVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIAC 212
Query: 961 GSNHTAVLLMDGQVFTFGSFSKGQLG 986
G ++ G+V+ +G GQLG
Sbjct: 213 GQMCCMAVVDTGEVYVWGYNGNGQLG 238
Score = 49.3 bits (116), Expect = 9e-05
Identities = 27/79 (34%), Positives = 44/79 (55%), Gaps = 2/79 (2%)
Query: 902 LRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA- 960
+R +V+CG+ H++VL + G VY +G +GQLG G+ +++ PT V ++ A
Sbjct: 257 IRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKDRIIEIAAC 316
Query: 961 GSNHT-AVLLMDGQVFTFG 978
S HT A G V+ +G
Sbjct: 317 HSTHTSAAKTQGGHVYMWG 335
Score = 48.5 bits (114), Expect = 2e-04
Identities = 26/76 (34%), Positives = 40/76 (52%), Gaps = 2/76 (2%)
Query: 913 HSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS--TQVTAGSNHTAVLLM 970
H V+ G+V+T+G+ + QLG+G N P + +V GS H+ VL
Sbjct: 110 HIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTS 169
Query: 971 DGQVFTFGSFSKGQLG 986
DG+VF +G + GQ+G
Sbjct: 170 DGEVFAWGYNNSGQVG 185
Score = 47.4 bits (111), Expect = 3e-04
Identities = 39/143 (27%), Positives = 66/143 (46%), Gaps = 25/143 (17%)
Query: 550 GHDGSHALLVAEDGSIFFTGSASKG----EDGESTKSRRQSKPYKPKKIIKMEGKIVVYT 605
G G+ L + IF G+ G D +ST +P+++ + GK +
Sbjct: 52 GSAGNEVLYTTVNDEIFVLGTNCCGCLGLGDVQST--------IEPRRLDSLNGKKIACL 103
Query: 606 ACNNGSSSVISK-DGELYMFGKDAIYSDSSS-----------LVTDLKGHFVTQVAMGKA 653
+ +G V++ +GE++ +G +A YS + + T+L V +VA G
Sbjct: 104 SYGSGPHIVLATTEGEVFTWGHNA-YSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSY 162
Query: 654 HTCVLMKNGEVWTFGVNNKGQCG 676
H+ VL +GEV+ +G NN GQ G
Sbjct: 163 HSLVLTSDGEVFAWGYNNSGQVG 185
>gi|7662402 BTB/POZ domain containing protein 3 isoform a [Homo
sapiens]
Length = 522
Score = 59.3 bits (142), Expect = 9e-08
Identities = 49/179 (27%), Positives = 79/179 (44%), Gaps = 19/179 (10%)
Query: 1175 ASTEEETQAVMKVYSKEDYSVVNRFES---HGGGWGYSAHSVEAIRFSADTDILLGGLGL 1231
A+ + E Q V K +RF+S W Y ++I+F+ D + + G GL
Sbjct: 354 AAKKPELQFVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRC-DSIQFAVDKRVFIAGFGL 412
Query: 1232 FG---GRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFDEPVLLQ 1288
+G G EY+AKI+L + G +L + + + + + F+ PV ++
Sbjct: 413 YGSSCGSAEYSAKIEL----------KRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIE 462
Query: 1289 AGWWYVAWARVSGPS-SDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLY 1346
+Y A + G S G G + V QF+ S S NGT V GQIP+L++
Sbjct: 463 PDTFYTASVILDGNELSYFGQEGMTEVQCGK-VTVQFQCSSDSTNGTGVQGGQIPELIF 520
Score = 45.1 bits (105), Expect = 0.002
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 16/144 (11%)
Query: 1704 GSPDAICFSVDKPGIVVVGFSVYGGG-GIHEYELEVLVDDSEHAGDSTHSHRWTSLELVK 1762
G D+I F+VDK + + GF +YG G EY ++ + + L
Sbjct: 392 GRCDSIQFAVDKR-VFIAGFGLYGSSCGSAEYSAKIEL-----------KRQGVVLGQNL 439
Query: 1763 GTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTAN-GDGGMTTVQCPDGVTFT 1821
Y +D S S+ + + V ++ + Y + G+ + G GMT VQC VT
Sbjct: 440 SKYFSDGS-SNTFPVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEVQCGK-VTVQ 497
Query: 1822 FSTCSLSSNGTNQTRGQIPQILYY 1845
F S S+NGT GQIP++++Y
Sbjct: 498 FQCSSDSTNGTGVQGGQIPELIFY 521
>gi|31317209 BTB/POZ domain containing protein 3 isoform b [Homo
sapiens]
Length = 461
Score = 59.3 bits (142), Expect = 9e-08
Identities = 49/179 (27%), Positives = 79/179 (44%), Gaps = 19/179 (10%)
Query: 1175 ASTEEETQAVMKVYSKEDYSVVNRFES---HGGGWGYSAHSVEAIRFSADTDILLGGLGL 1231
A+ + E Q V K +RF+S W Y ++I+F+ D + + G GL
Sbjct: 293 AAKKPELQFVSKARKGLVPQRCHRFQSCAYRSNQWRYRGRC-DSIQFAVDKRVFIAGFGL 351
Query: 1232 FG---GRGEYTAKIKLFELGPDGGDHETDGDLLAETDVLAYDCAAREKYAMMFDEPVLLQ 1288
+G G EY+AKI+L + G +L + + + + + F+ PV ++
Sbjct: 352 YGSSCGSAEYSAKIEL----------KRQGVVLGQNLSKYFSDGSSNTFPVWFEYPVQIE 401
Query: 1289 AGWWYVAWARVSGPS-SDCGSHGQASITTDDGVVFQFKSSKKSNNGTDVNAGQIPQLLY 1346
+Y A + G S G G + V QF+ S S NGT V GQIP+L++
Sbjct: 402 PDTFYTASVILDGNELSYFGQEGMTEVQCGK-VTVQFQCSSDSTNGTGVQGGQIPELIF 459
Score = 45.1 bits (105), Expect = 0.002
Identities = 42/144 (29%), Positives = 66/144 (45%), Gaps = 16/144 (11%)
Query: 1704 GSPDAICFSVDKPGIVVVGFSVYGGG-GIHEYELEVLVDDSEHAGDSTHSHRWTSLELVK 1762
G D+I F+VDK + + GF +YG G EY ++ + + L
Sbjct: 331 GRCDSIQFAVDKR-VFIAGFGLYGSSCGSAEYSAKIEL-----------KRQGVVLGQNL 378
Query: 1763 GTYTTDDSPSDIAEIRLDKVVPLKENVKYAVRLRNYGSRTAN-GDGGMTTVQCPDGVTFT 1821
Y +D S S+ + + V ++ + Y + G+ + G GMT VQC VT
Sbjct: 379 SKYFSDGS-SNTFPVWFEYPVQIEPDTFYTASVILDGNELSYFGQEGMTEVQCGK-VTVQ 436
Query: 1822 FSTCSLSSNGTNQTRGQIPQILYY 1845
F S S+NGT GQIP++++Y
Sbjct: 437 FQCSSDSTNGTGVQGGQIPELIFY 460
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 58.9 bits (141), Expect = 1e-07
Identities = 31/85 (36%), Positives = 50/85 (58%), Gaps = 1/85 (1%)
Query: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS-TQVTAG 961
R V ++CG S+ +++NG+VY +GY +GQLG G+ ++ P V AL Q+ G
Sbjct: 182 RVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCG 241
Query: 962 SNHTAVLLMDGQVFTFGSFSKGQLG 986
HT L +G ++ +G+ + GQLG
Sbjct: 242 YAHTLALTDEGLLYAWGANTYGQLG 266
Score = 52.0 bits (123), Expect = 1e-05
Identities = 54/195 (27%), Positives = 86/195 (44%), Gaps = 26/195 (13%)
Query: 504 LMKTANGKIYYTGK--YQSLG---IKQGGPSAGKWVELPITKSPKIVHFSVGHDGSHALL 558
L+ T +G +Y G Y LG QG L I + +V + G H++
Sbjct: 88 LLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQ---VVEVACG--SHHSMA 142
Query: 559 VAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIK-MEGKIVVYTACNNGSSSVISK 617
+A DG +F G + G+ G + + + + P+K+ + K VV AC SS +
Sbjct: 143 LAADGEVFAWGYNNCGQVGSGSTANQPT----PRKVTNCLHIKRVVGIACGQTSSMAVLD 198
Query: 618 DGELYMFGKDA-----IYSDSSSL----VTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFG 668
+GE+Y +G + + ++ + L V L V Q+ G AHT L G ++ +G
Sbjct: 199 NGEVYGWGYNGNGQLGLGNNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWG 258
Query: 669 VNNKGQCGRDTGAMN 683
N GQ G TG N
Sbjct: 259 ANTYGQLG--TGNKN 271
Score = 52.0 bits (123), Expect = 1e-05
Identities = 27/86 (31%), Positives = 45/86 (52%), Gaps = 2/86 (2%)
Query: 903 RAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPS--TQVTA 960
+ V+V+CG HHS+ L +G+V+ +GY GQ+G G ++ P V +
Sbjct: 129 QVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKRVVGIAC 188
Query: 961 GSNHTAVLLMDGQVFTFGSFSKGQLG 986
G + +L +G+V+ +G GQLG
Sbjct: 189 GQTSSMAVLDNGEVYGWGYNGNGQLG 214
Score = 48.9 bits (115), Expect = 1e-04
Identities = 27/76 (35%), Positives = 41/76 (53%), Gaps = 2/76 (2%)
Query: 913 HSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLV--QALPGPSTQVTAGSNHTAVLLM 970
H ++ E+G VY +G+ + QLG+G N P V L +V GS+H+ L
Sbjct: 86 HVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLIKQVVEVACGSHHSMALAA 145
Query: 971 DGQVFTFGSFSKGQLG 986
DG+VF +G + GQ+G
Sbjct: 146 DGEVFAWGYNNCGQVG 161
Score = 43.1 bits (100), Expect = 0.006
Identities = 45/171 (26%), Positives = 72/171 (42%), Gaps = 29/171 (16%)
Query: 531 GKWVELPITKSPKIVHFS----VGHDGSHALLVAEDGSIFFTG----SASKGEDGESTKS 582
GKW + +I G S AL V ++ +F G + D +ST
Sbjct: 5 GKWPIFTLLSPQEIASIRKACVFGTSASEALYVTDNDEVFVFGLNYSNCLGTGDNQST-- 62
Query: 583 RRQSKPYKPKKIIKMEGKIVVYTACNNGSSSVIS-KDGELYMFGKDAIYSDSSS------ 635
PKK+ + GK + + +G ++S +DG +Y +G + YS +
Sbjct: 63 ------LVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNG-YSQLGNGTTNQG 115
Query: 636 -----LVTDLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGA 681
+ T+L V +VA G H+ L +GEV+ +G NN GQ G + A
Sbjct: 116 IAPVQVCTNLLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTA 166
Score = 39.7 bits (91), Expect = 0.070
Identities = 23/75 (30%), Positives = 38/75 (50%), Gaps = 2/75 (2%)
Query: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQVTA-GSNH 964
Q+ CG+ H++ L + G +Y +G +GQLG G+ N+ P + ++ A S H
Sbjct: 237 QIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKERVVEIAACHSAH 296
Query: 965 T-AVLLMDGQVFTFG 978
T A G V+ +G
Sbjct: 297 TSAAKTQGGHVYMWG 311
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 58.5 bits (140), Expect = 1e-07
Identities = 30/81 (37%), Positives = 45/81 (55%), Gaps = 1/81 (1%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG-PSTQVTAGSNHT 965
V+CG + L + G + TFG G +G LGHG + PT+V+AL G QV G++H
Sbjct: 396 VACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHV 455
Query: 966 AVLLMDGQVFTFGSFSKGQLG 986
L + ++F +G G+LG
Sbjct: 456 LALSTERELFAWGRGDSGRLG 476
Score = 56.2 bits (134), Expect = 7e-07
Identities = 33/95 (34%), Positives = 46/95 (48%), Gaps = 2/95 (2%)
Query: 894 GSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPG 953
GS D E + + G HS + +GD YTFG QHGQLG P VQ L G
Sbjct: 554 GSAPLDQE-PLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEG 612
Query: 954 -PSTQVTAGSNHTAVLLMDGQVFTFGSFSKGQLGR 987
V G T + + +V+++G ++G+LGR
Sbjct: 613 IKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGR 647
Score = 52.4 bits (124), Expect = 1e-05
Identities = 36/113 (31%), Positives = 49/113 (43%), Gaps = 2/113 (1%)
Query: 876 GSGERGEKDASKITTYP-PGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQL 934
GSG G +T P V VQV+CG H + L +++ +G G G+L
Sbjct: 416 GSGSNGCLGHGSLTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRL 475
Query: 935 GHGDVNSRGCPTLVQALPGPSTQ-VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
G G S CP V PG Q V G + + +L + GQ GS +LG
Sbjct: 476 GLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLG 528
Score = 37.0 bits (84), Expect = 0.46
Identities = 26/92 (28%), Positives = 44/92 (47%), Gaps = 7/92 (7%)
Query: 537 PITKSPKIVHFSVGHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIK 596
P+ + P + S+ +H+ V G + GS G+ G T +RR S+ P K+
Sbjct: 557 PLDQEPLL---SIDLGTAHSAAVTASGDCYTFGSNQHGQLG--TNTRRGSRA--PCKVQG 609
Query: 597 MEGKIVVYTACNNGSSSVISKDGELYMFGKDA 628
+EG + AC + + I + E+Y +GK A
Sbjct: 610 LEGIKMAMVACGDAFTVAIGAESEVYSWGKGA 641
Score = 33.5 bits (75), Expect = 5.0
Identities = 24/90 (26%), Positives = 44/90 (48%), Gaps = 2/90 (2%)
Query: 861 SHPAQLKHKRDKHKDGSGERGEKDAS-KITTYPPGSVRFDCELRAVQVSCGFHHSVVLME 919
+H A + D + GS + G+ + + + P V+ ++ V+CG +V +
Sbjct: 571 AHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAIGA 630
Query: 920 NGDVYTFGYGQHGQLGHGDVNSRGCPTLVQ 949
+VY++G G G+LG D ++ G P VQ
Sbjct: 631 ESEVYSWGKGARGRLGRRDEDA-GLPRPVQ 659
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 58.2 bits (139), Expect = 2e-07
Identities = 75/278 (26%), Positives = 107/278 (38%), Gaps = 42/278 (15%)
Query: 2647 PPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKH---SRS 2703
PP P+S+ + +S + K DRG S SS P KS KH S S
Sbjct: 167 PPKPYSL--VRESSSSRSPTPKQKKKKKKKDRGRRSESSSPRRERKKSSKKKKHRSESES 224
Query: 2704 LK-----PDGRMSRTTADQKKPRGTESLSASES----LILKSDAAKLRSDSHSRSLSPNH 2754
K P + R + D+K+ R + A +S +D+A S SRS S
Sbjct: 225 KKRKHRSPTPKSKRKSKDKKRKRSRSTTPAPKSRRAHRSTSADSASSSDTSRSRSRSAAA 284
Query: 2755 NTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQ 2814
T T GR PS + G G S T SSP A+ SS DK+ +
Sbjct: 285 KT-HTTALAGRSPSPASGRR-GEGDAPFSEPGTTSTQRPSSPETATKQPSSPYEDKDKDK 342
Query: 2815 KSTAPVKTKLDPPRERSKSDSYTLDPDTLRKKK----------MPLTE----------PL 2854
K + T+ P ERS + P L ++ PL++ P
Sbjct: 343 KEKS--ATRPSPSPERSSTGPEPPAPTPLLAERHGGSPQPLATTPLSQEPVNPPSEASPT 400
Query: 2855 RGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHS 2892
R RS P+ +P+ S+ SE+ PSP + + H+
Sbjct: 401 RDRSPPKSPEKLPQSSS----SESSPPSPQPTKVSRHA 434
Score = 52.4 bits (124), Expect = 1e-05
Identities = 54/221 (24%), Positives = 93/221 (42%), Gaps = 24/221 (10%)
Query: 2657 NKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKHSRSLKP-------DGR 2709
+ +S S+ +S G+ S+ S+ +S + E++ K S P +GR
Sbjct: 2535 SSSSSSSSSSSSSSSSSSSSSSGSSSSDSEGSSLPVQPEVALKRVPSPTPAPKEAVREGR 2594
Query: 2710 MSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGR---- 2765
T ++K R + S S+S S S ++ S S S S S + ++ + S
Sbjct: 2595 PPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP 2654
Query: 2766 ----MPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSP---RSSSPHDKNLPQKSTA 2818
+P + + P PG R S K + + R S S + SP R SP Q+S++
Sbjct: 2655 GPQALPKPASPKKPPPGERRSRSPRKPIDSLRDSRSLSYSPVERRRPSPQPSPRDQQSSS 2714
Query: 2819 PVKTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGRST 2859
+ R S+S S+ R+++ P P+R RS+
Sbjct: 2715 SERGSRRGQRGDSRSPSHK------RRRETPSPRPMRHRSS 2749
Score = 52.0 bits (123), Expect = 1e-05
Identities = 58/217 (26%), Positives = 80/217 (36%), Gaps = 9/217 (4%)
Query: 2671 LGNSKGDRGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRGTESL-SAS 2729
+G G S+ A K SS S S S +++ G+ S S
Sbjct: 2506 VGEPPASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSDSEG 2565
Query: 2730 ESLILKSDAAKLRSDSHS-------RSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLS 2782
SL ++ + A R S + R P T K SSS + S S S
Sbjct: 2566 SSLPVQPEVALKRVPSPTPAPKEAVREGRPPEPTPAKRKRRSSSSSSSSSSSSSSSSSSS 2625
Query: 2783 SPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDT 2842
S + ++ SS S +SS SS K PQ P K PP ER +S S D+
Sbjct: 2626 SSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGER-RSRSPRKPIDS 2684
Query: 2843 LRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENR 2879
LR + P+ R SP+P + S+ S R
Sbjct: 2685 LRDSRSLSYSPVERRRPSPQPSPRDQQSSSSERGSRR 2721
Score = 51.2 bits (121), Expect = 2e-05
Identities = 113/479 (23%), Positives = 171/479 (35%), Gaps = 109/479 (22%)
Query: 2658 KGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSG------KSELSSKHSRSL-----KP 2706
+G S S G S +R N S +S+ S S KS +SS+ SRSL K
Sbjct: 710 RGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISSRRSRSLSSPRSKA 769
Query: 2707 DGRMS---------------------RTTADQKKPRGTESLSASESLILKSDAAKLRSDS 2745
R+S R+ + +P+ S S K +S +
Sbjct: 770 KSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRTPPRRSRSSSSPPPKQKSKT 829
Query: 2746 HSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRL----------SSPKP--KTLPANR 2793
SR + + +KS G P SP + SSP P K+ +R
Sbjct: 830 PSRQSHSSSSPHPKVKS-GTPPRQGSITSPQANEQSVTPQRRSCFESSPDPELKSRTPSR 888
Query: 2794 SSPSGASSPR-SSSPHDKNLPQKSTAPV-KTK-LDPPRERSKSDSYTLDPDTLRKKKMPL 2850
S SG+S PR SS + P +S++P K K + PR+RS S S + P + +
Sbjct: 889 HSCSGSSPPRVKSSTPPRQSPSRSSSPQPKVKAIISPRQRSHSGSSSPSPSRVTSR---- 944
Query: 2851 TEPLRGRSTSP------------------------KPKSVPKDSTDS------------- 2873
T P R RS SP KP++ P+ S
Sbjct: 945 TTPRRSRSVSPCSNVESRLLPRYSHSGSSSPDTKVKPETPPRQSHSGSISPYPKVKAQTP 1004
Query: 2874 PG---SENRAPSPHVVQENLHSEVVEVCTSSTLKTNSLTDSTCDDSSEFKSVDEGSNKVH 2930
PG S +++P P QE +V+ C S + ST S F G + +
Sbjct: 1005 PGPSLSGSKSPCP---QEKSKDSLVQSCPGSLSLCAGVKSSTPPGESYF-----GVSSLQ 1056
Query: 2931 FSIGKAPLKDEQEMRASPKISRKCANRHTRPKKEKSSFLFKGDGSKPLEPAKQAMSPSVA 2990
D + +SP++ + + + K ++S KG S+ P + S S
Sbjct: 1057 LKGQSQTSPDHRSDTSSPEVRQSHSESPSLQSKSQTS--PKGGRSRSSSPVTELASRSPI 1114
Query: 2991 ECARAVF-ASFLWHEGIVHDAMACSSFLKFHPELSKEHAPIRSSLNSQQPTEEKETKLK 3048
R F AS + G+ + S +P + +SL Q E E+K K
Sbjct: 1115 RQDRGEFSASPMLKSGMSPEQSRFQSDSSSYPTVDS------NSLLGQSRLETAESKEK 1167
Score = 50.8 bits (120), Expect = 3e-05
Identities = 81/315 (25%), Positives = 123/315 (39%), Gaps = 37/315 (11%)
Query: 2694 SELSSKHSRSLKPDG-RMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSP 2752
++L + S +K R S ++ + P E S + + S + SR S
Sbjct: 1361 NQLETDPSLDMKEQSTRSSGHSSSELSPDAVEKAGMSSNQSISSPVLDAVPRTPSRERSS 1420
Query: 2753 NHNTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPRS-------- 2804
+ ++ + R PS PG R S P + SSP PR+
Sbjct: 1421 SASSPEMKDGLPRTPSRRSRSGSSPGLRDGSGTPSRHSLSGSSPGMKDIPRTPSRGRSEC 1480
Query: 2805 -SSPHDKNLPQ----KSTAPVKTKLD-----PPRERSKSDSYTLDPDTLRKKKMPLTEPL 2854
SSP K LPQ +S +P +L+ P RERS S+S ++D T+ + PL +
Sbjct: 1481 DSSPEPKALPQTPRPRSRSPSSPELNNKCLTPQRERSGSES-SVDQKTV--ARTPLGQRS 1537
Query: 2855 RGRSTSP---KPKSVPK---DSTDSPGSENRAPSPHVVQENLHSEVVEVCTSSTLKTNSL 2908
R S+ KP + P+ +S SP S+ + +P + Q + EV + S L S
Sbjct: 1538 RSGSSQELDVKPSASPQERSESDSSPDSKAKTRTP-LRQRSRSGSSPEVDSKSRL---SP 1593
Query: 2909 TDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKDEQEMRASPKISRKCANRHTR-PKKEKSS 2967
S S E K + + +P RA P+ SR ++ R P E SS
Sbjct: 1594 RRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSS 1653
Query: 2968 FLFKGDGSKPLEPAK 2982
S P P K
Sbjct: 1654 ----STESSPEHPPK 1664
Score = 47.0 bits (110), Expect = 4e-04
Identities = 51/206 (24%), Positives = 78/206 (37%), Gaps = 21/206 (10%)
Query: 2682 STSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRGTESLSASESLILKSDAAKL 2741
S S KS LS + SRS + A + G++S ++ ++ +
Sbjct: 1577 SRSGSSPEVDSKSRLSPRRSRSGSSPEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRS 1636
Query: 2742 RSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKTL----PANRSSPS 2797
RS S S+ P+ + +S P SR G SR SSP+PKT P RSS S
Sbjct: 1637 RSGSSSKGRGPSPEGSSSTESSPEHPPKSRTARRG--SR-SSPEPKTKSRTPPRRRSSRS 1693
Query: 2798 GASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGR 2857
R + ++ S+ +++ P RS S S EP
Sbjct: 1694 SPELTRKARLSRRSRSASSSPETRSRTPPRHRRSPSVSSP--------------EPAEKS 1739
Query: 2858 STSPKPKSVPKDSTDSPGSENRAPSP 2883
+S + +S T + R+PSP
Sbjct: 1740 RSSRRRRSASSPRTKTTSRRGRSPSP 1765
Score = 44.7 bits (104), Expect = 0.002
Identities = 57/248 (22%), Positives = 96/248 (38%), Gaps = 27/248 (10%)
Query: 2640 DQNSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSK 2699
D + + P+P ++ ++ S S G G+ ST S P KS + +
Sbjct: 1619 DSSPEPKAPAPRALPRRSRSGSSSK-------GRGPSPEGSSSTESSPEHPP-KSRTARR 1670
Query: 2700 HSRSLKPDGRMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQT 2759
SRS SRT ++ R + L+ L +S +A ++ SR+ P H
Sbjct: 1671 GSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSRT-PPRHR---- 1725
Query: 2760 LKSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAP 2819
R PS S SP P + S + + ++ + + + RS SP + L + +
Sbjct: 1726 -----RSPSVS---SPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPRGLQRSRSRS 1777
Query: 2820 --VKTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRG----RSTSPKPKSVPKDSTDS 2873
KT+ R+RS S T + + +T RG S SP + + S+
Sbjct: 1778 RREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRVTRRRRGGSGYHSRSPARQESSRTSSRR 1837
Query: 2874 PGSENRAP 2881
+R P
Sbjct: 1838 RRGRSRTP 1845
Score = 43.9 bits (102), Expect = 0.004
Identities = 88/419 (21%), Positives = 151/419 (36%), Gaps = 37/419 (8%)
Query: 2669 YGLGNSKGDRGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRGTESLSA 2728
+G S RG + +P + ++ SRS + SR+ A + + R
Sbjct: 522 WGRSRSPQRRGRSRSPQRPGWSRSRNTQRRGRSRSARRGRSHSRSPATRGRSRSRTPARR 581
Query: 2729 SESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKT 2788
S + RS + +R S + + +S R P+ R+ + P R S +
Sbjct: 582 GRSRSRTPARRRSRSRTPTRRRSRSRTPARRGRSRSRTPARRRSRTRSPVRRRSRSRS-- 639
Query: 2789 LPANRSSPSGASSP------RSSSPHDKNLPQKST---APVKTKLDPPRERSKSDSYTLD 2839
PA RS S + +P RS +P + + T +++ P R +S S T
Sbjct: 640 -PARRSGRSRSRTPARRGRSRSRTPARRGRSRSRTPARRSGRSRSRTPARRGRSRSRT-- 696
Query: 2840 PDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHSEVVEVCT 2899
P R + L RGRS S P+ + + S S + N E+ +
Sbjct: 697 PRRGRSRSRSLVR--RGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRI 754
Query: 2900 SSTLKTNSLTD--STCDDSSEFKSVDEGSNKVHFSIGKAPLKDEQEMRASPKISRKCANR 2957
SS ++ SL+ S + GS+ + P + + + PK A
Sbjct: 755 SSR-RSRSLSSPRSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPK-----AKS 808
Query: 2958 HTRPKKEKSSFLFKGDGSKPLEPAKQAMSPSVAECARAVFASFLWHEGIVHDAMACSSFL 3017
T P++ +SS S P P +++ +PS R +S H + +
Sbjct: 809 RTPPRRSRSS-------SSP-PPKQKSKTPS-----RQSHSSSSPHPKVKSGTPPRQGSI 855
Query: 3018 KFHPELSKEHAPIRSSLNSQQPTEEKETKLKNRHSLEISSALNMFNIAPHGPDISKMGS 3076
+ P R S P E +++ +RHS SS + + P S+ S
Sbjct: 856 TSPQANEQSVTPQRRSCFESSPDPELKSRTPSRHSCSGSSPPRVKSSTPPRQSPSRSSS 914
Score = 43.5 bits (101), Expect = 0.005
Identities = 71/331 (21%), Positives = 123/331 (37%), Gaps = 57/331 (17%)
Query: 2684 SSKPASTSGKSELSSKHSRSLKPDGRMSRTTAD------QKKPRG---------TESLSA 2728
S P S +S ++S+ + S P RM + + Q +PR + L A
Sbjct: 2407 SRTPPSAPSQSRMTSERAPS--PSSRMGQAPSQSLLPPAQDQPRSPVPSAFSDQSRCLIA 2464
Query: 2729 SESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDG-------RMPSSSRAESPGPGSRL 2781
+ + S + + + + S + +HN + ++ + G P+S+ A+ P + L
Sbjct: 2465 QTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPHSDVGEPPASTGAQQPSALAAL 2524
Query: 2782 SSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPD 2841
K + ++ SS S +SS SSS + S++ S+ S + P+
Sbjct: 2525 QPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSSD-----------SEGSSLPVQPE 2573
Query: 2842 TLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHSEVVEVCTSS 2901
K+ P P PK++ E R P P + S +SS
Sbjct: 2574 VALKR-------------VPSPTPAPKEAV----REGRPPEPTPAKRKRRSS-SSSSSSS 2615
Query: 2902 TLKTNSLTDSTCDDSSEFKSVDEGSNKVHFSIGKAPLKDEQE---MRASPKISRKCANRH 2958
+ ++S + S+ SS S S+ S +P K + ASPK R
Sbjct: 2616 SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPPGERRS 2675
Query: 2959 TRPKKEKSSFLFKGDGS-KPLEPAKQAMSPS 2988
P+K S S P+E + + PS
Sbjct: 2676 RSPRKPIDSLRDSRSLSYSPVERRRPSPQPS 2706
Score = 40.0 bits (92), Expect = 0.054
Identities = 45/163 (27%), Positives = 63/163 (38%), Gaps = 18/163 (11%)
Query: 2647 PPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKHSRSLKP 2706
PP P + + +S S+ +S + S+SS +S+S S SS KP
Sbjct: 2595 PPEPTPAKRKRRSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKP 2654
Query: 2707 DGRMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRM 2766
+ A KKP E S S + S LR DS S S SP + + R
Sbjct: 2655 GPQALPKPASPKKPPPGERRSRSPRKPIDS----LR-DSRSLSYSPVERRRPSPQPSPRD 2709
Query: 2767 PSSSRAE------------SPGPGSRLSSPKPKTLPANRSSPS 2797
SS +E SP R +P P+ + +RSS S
Sbjct: 2710 QQSSSSERGSRRGQRGDSRSPSHKRRRETPSPRPM-RHRSSRS 2751
Score = 35.4 bits (80), Expect = 1.3
Identities = 49/212 (23%), Positives = 78/212 (36%), Gaps = 13/212 (6%)
Query: 2678 RGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRGTESLSA-SESLILKS 2736
RG S+ + S SS+ R GR +K+ R S + S S
Sbjct: 1815 RGGSGYHSRSPARQESSRTSSRRRR-----GRSRTPPTSRKRSRSRTSPAPWKRSRSRAS 1869
Query: 2737 DAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSP 2796
A RS S + +S + +T R S + + +SP + +R+ P
Sbjct: 1870 PATHRRSRSRTPLISRRRSRSRTSPVSRRRSRSRTSVTRRRSRSRASPVSRRRSRSRTPP 1929
Query: 2797 SGASSPRSSSPHDKNLPQKSTAPVKTKLD----PP--RERSKSDSYTLDPDTLRKKKMPL 2850
RS +P + + T PV + PP R RS+S + + R + P+
Sbjct: 1930 VTRRRSRSRTPTTRRRSRSRTPPVTRRRSRSRTPPVTRRRSRSRTSPITRRRSRSRTSPV 1989
Query: 2851 TEPLRGRSTSPKPKSVPKDSTDSPGSENRAPS 2882
T TSP + + T SP + R+ S
Sbjct: 1990 TRRRSRSRTSPVTRRRSRSRT-SPVTRRRSRS 2020
Score = 35.0 bits (79), Expect = 1.7
Identities = 31/114 (27%), Positives = 48/114 (42%), Gaps = 9/114 (7%)
Query: 2761 KSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPV 2820
KS ++P SS +ES S P P+ +R + S SP+ + + S+
Sbjct: 407 KSPEKLPQSSSSES-------SPPSPQPTKVSRHASSSPESPKPAPAPGSHREISSSPTS 459
Query: 2821 KTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSP 2874
K + +R KS S+T + + + P T RGRS S P + SP
Sbjct: 460 KNRSHGRAKRDKSHSHT-PSRRMGRSRSPATAK-RGRSRSRTPTKRGHSRSRSP 511
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 56.2 bits (134), Expect = 7e-07
Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 5/98 (5%)
Query: 894 GSVRFDC----ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQ 949
G R+ C +R V HS+++ G ++++G + GQLGHGD P L++
Sbjct: 138 GPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197
Query: 950 ALPGP-STQVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
L G NHT L G VF FG GQLG
Sbjct: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLG 235
Score = 50.8 bits (120), Expect = 3e-05
Identities = 26/83 (31%), Positives = 45/83 (54%), Gaps = 1/83 (1%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSN 963
V +CG +H++ L E G V+ FG + GQLG G+ ++ P + P T++ G+
Sbjct: 205 VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAE 264
Query: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
+ ++ G +++FG GQLG
Sbjct: 265 FSMIMDCKGNLYSFGCPEYGQLG 287
Score = 48.9 bits (115), Expect = 1e-04
Identities = 30/139 (21%), Positives = 64/139 (46%), Gaps = 13/139 (9%)
Query: 550 GHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNN 609
G +H+LL+ +G ++ G KG+ G R ++ P+ I + +++V AC
Sbjct: 156 GSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEA----PRLIEGLSHEVIVSAACGR 211
Query: 610 GSSSVISKDGELYMFGKDAIYSDSSSLVTD---------LKGHFVTQVAMGKAHTCVLMK 660
+ +++ G ++ FG++ + TD G +T++A G + ++
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
Query: 661 NGEVWTFGVNNKGQCGRDT 679
G +++FG GQ G ++
Sbjct: 272 KGNLYSFGCPEYGQLGHNS 290
Score = 43.5 bits (101), Expect = 0.005
Identities = 23/76 (30%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGP---STQVTAGSN 963
V+CG +H++VL V+++G+G +G+LGH + P LV+ P ++Q+ AG
Sbjct: 335 VACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYT 394
Query: 964 HTAVLLMDGQVFTFGS 979
+ + G +F +G+
Sbjct: 395 CSFAVSEVGGLFFWGA 410
Score = 43.1 bits (100), Expect = 0.006
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 25/106 (23%)
Query: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG------------DVNSRGCPTLV----- 948
+++CG S+++ G++Y+FG ++GQLGH + + P V
Sbjct: 258 KMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIE 317
Query: 949 -----QALPGPST---QVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
Q LP P+ V G+NHT VL +VF++G G+LG
Sbjct: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLG 363
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 56.2 bits (134), Expect = 7e-07
Identities = 33/98 (33%), Positives = 45/98 (45%), Gaps = 5/98 (5%)
Query: 894 GSVRFDC----ELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQ 949
G R+ C +R V HS+++ G ++++G + GQLGHGD P L++
Sbjct: 138 GPHRYGCLAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIE 197
Query: 950 ALPGP-STQVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
L G NHT L G VF FG GQLG
Sbjct: 198 GLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLG 235
Score = 50.8 bits (120), Expect = 3e-05
Identities = 26/83 (31%), Positives = 45/83 (54%), Gaps = 1/83 (1%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSN 963
V +CG +H++ L E G V+ FG + GQLG G+ ++ P + P T++ G+
Sbjct: 205 VSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAE 264
Query: 964 HTAVLLMDGQVFTFGSFSKGQLG 986
+ ++ G +++FG GQLG
Sbjct: 265 FSMIMDCKGNLYSFGCPEYGQLG 287
Score = 48.9 bits (115), Expect = 1e-04
Identities = 30/139 (21%), Positives = 64/139 (46%), Gaps = 13/139 (9%)
Query: 550 GHDGSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNN 609
G +H+LL+ +G ++ G KG+ G R ++ P+ I + +++V AC
Sbjct: 156 GSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEA----PRLIEGLSHEVIVSAACGR 211
Query: 610 GSSSVISKDGELYMFGKDAIYSDSSSLVTD---------LKGHFVTQVAMGKAHTCVLMK 660
+ +++ G ++ FG++ + TD G +T++A G + ++
Sbjct: 212 NHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDC 271
Query: 661 NGEVWTFGVNNKGQCGRDT 679
G +++FG GQ G ++
Sbjct: 272 KGNLYSFGCPEYGQLGHNS 290
Score = 43.5 bits (101), Expect = 0.005
Identities = 23/76 (30%), Positives = 43/76 (56%), Gaps = 3/76 (3%)
Query: 907 VSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGP---STQVTAGSN 963
V+CG +H++VL V+++G+G +G+LGH + P LV+ P ++Q+ AG
Sbjct: 335 VACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQIYAGYT 394
Query: 964 HTAVLLMDGQVFTFGS 979
+ + G +F +G+
Sbjct: 395 CSFAVSEVGGLFFWGA 410
Score = 43.1 bits (100), Expect = 0.006
Identities = 31/106 (29%), Positives = 50/106 (47%), Gaps = 25/106 (23%)
Query: 906 QVSCGFHHSVVLMENGDVYTFGYGQHGQLGHG------------DVNSRGCPTLV----- 948
+++CG S+++ G++Y+FG ++GQLGH + + P V
Sbjct: 258 KMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIFIE 317
Query: 949 -----QALPGPST---QVTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
Q LP P+ V G+NHT VL +VF++G G+LG
Sbjct: 318 KTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLG 363
>gi|40316935 alsin isoform 1 [Homo sapiens]
Length = 1657
Score = 55.8 bits (133), Expect = 9e-07
Identities = 36/109 (33%), Positives = 52/109 (47%), Gaps = 10/109 (9%)
Query: 922 DVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAGSNHTAVLLMDGQVFTFGSF 980
+V+T+G G+ GQLGHGDV R P V+ L G + AG H+ L QV+++GS
Sbjct: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
Query: 981 SKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATW-IGASGDQTFLRID 1028
+ GQLG + P +P + W I A D + +D
Sbjct: 587 TFGQLGH--------SDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVD 627
Score = 47.0 bits (110), Expect = 4e-04
Identities = 30/97 (30%), Positives = 45/97 (46%), Gaps = 7/97 (7%)
Query: 586 SKPYKPKKIIKMEGKIVVYTACNNGSSSVISKDGELYMFGK-------DAIYSDSSSLVT 638
S P P+++ GK V+ A ++++DGE+Y FG I S L
Sbjct: 27 SFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILEN 86
Query: 639 DLKGHFVTQVAMGKAHTCVLMKNGEVWTFGVNNKGQC 675
L G +V VA G H+ + NG + +G N+ GQC
Sbjct: 87 ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQC 123
Score = 37.4 bits (85), Expect = 0.35
Identities = 25/85 (29%), Positives = 42/85 (49%), Gaps = 11/85 (12%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGCPTLVQALPGPSTQ-----VT 959
+ + G +HS+ L VY++G GQLGH D PT V L S++ +
Sbjct: 562 IHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF-----PTTVPRLAKISSENGVWSIA 616
Query: 960 AGSNHTAVLLMDGQVFTFGSFSKGQ 984
AG ++ ++ L+D + F G + G+
Sbjct: 617 AGRDY-SLFLVDTEDFQPGLYYSGR 640
Score = 36.2 bits (82), Expect = 0.78
Identities = 34/121 (28%), Positives = 53/121 (43%), Gaps = 5/121 (4%)
Query: 867 KHKRDKHKDGSGERGEKDASKITTYPPGSVRFDC--ELRAVQVSCGFHHSVVLMENGDVY 924
K + +GS ERG + ++P R +Q + G H V+L E+G+VY
Sbjct: 4 KKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVY 63
Query: 925 TFGYGQHGQLGHGDVNSRGCPTLVQALPGPST-QVTAGSNHTAVLLMDGQVFTFGSFSKG 983
+FG + G ++ P L AL G V GS H+ + +G + +G S G
Sbjct: 64 SFG-TLPWRSGPVEI-CPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAG 121
Query: 984 Q 984
Q
Sbjct: 122 Q 122
Score = 34.3 bits (77), Expect = 3.0
Identities = 28/130 (21%), Positives = 53/130 (40%), Gaps = 22/130 (16%)
Query: 555 HALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSSSV 614
H +L+ EDG ++ G+ + P P + G+ V+ A + S
Sbjct: 52 HGVLLTEDGEVYSFGTLPW------RSGPVEICPSSPILENALVGQYVITVATGSFHSGA 105
Query: 615 ISKDGELYMFGKDAI----------------YSDSSSLVTDLKGHFVTQVAMGKAHTCVL 658
++ +G YM+G+++ S + S + L + Q+A G+ HT L
Sbjct: 106 VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLAL 165
Query: 659 MKNGEVWTFG 668
+ E+W +G
Sbjct: 166 SISREIWAWG 175
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 55.1 bits (131), Expect = 2e-06
Identities = 83/378 (21%), Positives = 140/378 (37%), Gaps = 41/378 (10%)
Query: 2577 GMLVLGNKVKAVGEVTNSEGTWVQLDQNSMVEFC------------------ESDEGEAW 2618
GM++ VK GEV N EG + + + V +S +G+
Sbjct: 406 GMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDP 465
Query: 2619 SLARDRGGNQYLRHEDEQALLDQNSQTPPPSPF-SVQAFNKGASCSAQGFDYGLGNSKGD 2677
+ + + GN +D + D NS + + + S ++ + G ++G + +S D
Sbjct: 466 NSSDESNGN-----DDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSD 520
Query: 2678 --------RGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRGTESLSAS 2729
GN S SGK + S S S D S ++D ++S S+S
Sbjct: 521 TNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDS--SDSSNSSDSSDSSDSDSSDSNSSS 578
Query: 2730 ESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKTL 2789
+S SD+ SDS S + N+ + SD S S S S+ S K ++
Sbjct: 579 DSDSSDSDS----SDSSDSDSSDSSNSSDS--SDSSDSSDSSDSSDSSDSKSDSSKSESD 632
Query: 2790 PANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDTLRKKKMP 2849
++ S S +S SS D N ++ D SDS + +
Sbjct: 633 SSDSDSKSDSSDSNSSDSSD-NSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSD 691
Query: 2850 LTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHSEVVEVCTSSTLKTNSLT 2909
++ +S S DS+DS S N S + S + S+ ++S
Sbjct: 692 SSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSN 751
Query: 2910 DSTCDDSSEFKSVDEGSN 2927
S DSS+ + + S+
Sbjct: 752 SSDSSDSSDSSNSSDSSD 769
Score = 53.1 bits (126), Expect = 6e-06
Identities = 63/287 (21%), Positives = 110/287 (38%), Gaps = 7/287 (2%)
Query: 2642 NSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKHS 2701
+S + S S + + +S S+ D + D N S S+ +++S S+ S+
Sbjct: 743 SSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSD 802
Query: 2702 RSLKPDGRMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTLK 2761
S D S ++D ++S ++S+S SD++ S S S ++ + +
Sbjct: 803 SSNSSDSSDSSDSSDSDSSNSSDSSNSSDS----SDSSNSSDSSDSSDSSDGSDSDSSNR 858
Query: 2762 SDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPVK 2821
SD S S S S SS + ++ SS S SS S S + ++
Sbjct: 859 SDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSS 918
Query: 2822 TKLDPPRERSKSD-SYTLDPDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRA 2880
D + SD S + D S++ S DS+DS S++
Sbjct: 919 NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSD 978
Query: 2881 PSPHVVQENLHSEVVEVCTSSTLKTNSLTDSTCDDSSEFKSVDEGSN 2927
S ++ S + S+ +NS S DSS+ + + SN
Sbjct: 979 SSNS--SDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSN 1023
Score = 50.1 bits (118), Expect = 5e-05
Identities = 67/283 (23%), Positives = 109/283 (38%), Gaps = 14/283 (4%)
Query: 2640 DQNSQTPPPSPFSVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSK 2699
D +S S S + + +S S D +S + S SS +++S S+ S
Sbjct: 551 DSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDS 610
Query: 2700 HSRSLKPDGRMSRTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQT 2759
S D S++ + + + ++S S S+S S + SDS S S N +
Sbjct: 611 SDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSD--- 667
Query: 2760 LKSDGRMPSSSRAESPGPGSRLSSPKPKTLPANRSSPSGASSPR-SSSPHDKNLPQKSTA 2818
SD S S + S S SS + ++ SS S SS SS D + S +
Sbjct: 668 -SSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDS 726
Query: 2819 PVKTKLDPPRERSKSDSYTLDPDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSEN 2878
D + SDS + ++ S++ S DS+DS S N
Sbjct: 727 DSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSD-----SSNSSDSSDSSDSSDSSDSSN 781
Query: 2879 RAPSPHVVQENLHSEVVEVCTSSTLKTNSLTDSTCDDSSEFKS 2921
+ S ++ +S ++S+ +NS S DSS+ S
Sbjct: 782 SSDS----NDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDS 820
Score = 48.1 bits (113), Expect = 2e-04
Identities = 71/324 (21%), Positives = 115/324 (35%), Gaps = 13/324 (4%)
Query: 2611 ESDEGEAWSLARDRGGNQYLRHEDEQALLDQNSQTPPPSPFS-------VQAFNKGASCS 2663
+SD G+ S + D + D D +S S S + + +S S
Sbjct: 539 KSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDS 598
Query: 2664 AQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKHSRSLKPDGRMSRTTADQKKPRGT 2723
+ D + D + S SS S S KSE S S S K D S ++ +
Sbjct: 599 SNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDS-KSDSSDSNSSDSSDNSDSS 657
Query: 2724 ESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLSS 2783
+S ++S S SD++ S S S S + N+ + S SS ++S SS
Sbjct: 658 DSSNSSNS----SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSS 713
Query: 2784 PKPKTLPANRS-SPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDT 2842
+ +N S S S SS S S + + S + + + S S + D+
Sbjct: 714 DSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDS 773
Query: 2843 LRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHSEVVEVCTSST 2902
+ S S S S S++ S ++ +S + S+
Sbjct: 774 SDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSS 833
Query: 2903 LKTNSLTDSTCDDSSEFKSVDEGS 2926
+NS S DSS+ D +
Sbjct: 834 DSSNSSDSSDSSDSSDGSDSDSSN 857
Score = 47.0 bits (110), Expect = 4e-04
Identities = 66/336 (19%), Positives = 112/336 (33%), Gaps = 11/336 (3%)
Query: 2592 TNSEGTWVQLDQNSMVEFCESDEGEAWSLARDRGGNQYLRHEDEQALLDQNSQTPPPSPF 2651
+NS + D + + +SD + + + D D + + S
Sbjct: 798 SNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSN 857
Query: 2652 SVQAFNKGASCSAQGFDYGLGNSKGDRGNISTSSKPASTSGKSELSSKHSRSLKPDGRMS 2711
+ N S + +S N S++S +S S S S S D S
Sbjct: 858 RSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDS 917
Query: 2712 RTTADQKKPRGTESLSASESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSR 2771
++D + + S S SD++ S+S S + ++ + S S S
Sbjct: 918 SNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSS 977
Query: 2772 AESPGPGSRLSSPKPKTLPANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERS 2831
S S SS + ++ SS S SS S S N S + + + S
Sbjct: 978 DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSS 1037
Query: 2832 KSDSYTLDPDTLRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLH 2891
S + D+ S+ S DS+DS S + + S E+
Sbjct: 1038 DSSDSSDSSDSSDSSD-------SSNSSDSSDSSDSSDSSDSSDSSDSSDS----SESSD 1086
Query: 2892 SEVVEVCTSSTLKTNSLTDSTCDDSSEFKSVDEGSN 2927
S + S+ ++S S DSS+ + SN
Sbjct: 1087 SSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSN 1122
Score = 38.1 bits (87), Expect = 0.20
Identities = 63/270 (23%), Positives = 94/270 (34%), Gaps = 29/270 (10%)
Query: 2678 RGNISTSSKPASTSG---KSELSSK--HSRS---LKPDGRMSRTTADQKKPRGTESLSAS 2729
+GN+ T + + G KSE +K HS + DG S D K +G + S+
Sbjct: 411 KGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDF-DDKSMQGDDPNSSD 469
Query: 2730 ESLILKSDAAKLRSDSHSRSLSPNHNTLQTLKSDGRMPSSSRAESPGPGSRLSSPKPKTL 2789
ES +D A SD++S S K +G S AE S + +
Sbjct: 470 ESN--GNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSN 527
Query: 2790 -------PANRSSPSGASSPRSSSPHDKNLPQKSTAPVKTKLDPPRERSKSDSYTLDPDT 2842
N S SG SS + S + + D S SDS + D D+
Sbjct: 528 GNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDS 587
Query: 2843 LRKKKMPLTEPLRGRSTSPKPKSVPKDSTDSPGSENRAPSPHVVQENLHSEVVEVCTSST 2902
+ S DS+DS S + + S S E +S +
Sbjct: 588 SDSS-----------DSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDS 636
Query: 2903 LKTNSLTDSTCDDSSEFKSVDEGSNKVHFS 2932
+ +DS DSS+ + SN + S
Sbjct: 637 DSKSDSSDSNSSDSSDNSDSSDSSNSSNSS 666
>gi|114796646 regulator of chromosome condensation 1 isoform b [Homo
sapiens]
Length = 438
Score = 53.9 bits (128), Expect = 4e-06
Identities = 48/133 (36%), Positives = 60/133 (45%), Gaps = 21/133 (15%)
Query: 856 LARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSV 915
+A+ RS PA K K KD + PG+ R+ QVS H +
Sbjct: 6 IAKRRSPPADAIPKSKKVKDTRAAASRR--------VPGA-------RSCQVSHRSHST- 49
Query: 916 VLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQV 974
E G V T G G GQLG G+ V R P LV ++P Q AG HT L GQV
Sbjct: 50 ---EPGLVLTLGQGDVGQLGLGENVMERKKPALV-SIPEDVVQAEAGGMHTVCLSKSGQV 105
Query: 975 FTFGSFSKGQLGR 987
++FG +G LGR
Sbjct: 106 YSFGCNDEGALGR 118
Score = 53.1 bits (126), Expect = 6e-06
Identities = 34/79 (43%), Positives = 44/79 (55%), Gaps = 5/79 (6%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGC---PTLVQALPGPSTQVTAG 961
VQ G H+V L ++G VY+FG G LG D + G P V+ L QV+AG
Sbjct: 87 VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVE-LQEKVVQVSAG 144
Query: 962 SNHTAVLLMDGQVFTFGSF 980
+HTA L DG+VF +GSF
Sbjct: 145 DSHTAALTDDGRVFLWGSF 163
Score = 50.8 bits (120), Expect = 3e-05
Identities = 36/119 (30%), Positives = 58/119 (48%), Gaps = 7/119 (5%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSN 963
V S G HH+V + G Y+ G ++G+LG G+ + PTL+ LP S+ V G++
Sbjct: 314 VGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSS-VACGAS 372
Query: 964 HTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQ 1022
+ DG+VF +G + QLG D W +P+ +G + + +SG Q
Sbjct: 373 VGYAVTKDGRVFAWGMGTNYQLGTG-QDEDAW----SPVEMMGKQLENRVVLSVSSGGQ 426
Score = 46.2 bits (108), Expect = 8e-04
Identities = 80/347 (23%), Positives = 120/347 (34%), Gaps = 93/347 (26%)
Query: 645 VTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEE 704
V Q G HT L K+G+V++FG N++G GRDT
Sbjct: 86 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV----------------------- 122
Query: 705 ELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGE 764
E S M P K +L++ +V GD + A+ GR + GS
Sbjct: 123 ------EGSEMVP---GKVELQEKVVQVSAGD--SHTAALTDDGR-------VFLWGSFR 164
Query: 765 SGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGV-NIEEHL-QLRQE 822
V G + K M+P+ + L VPV V + +HL L +
Sbjct: 165 DNNGVIGLLEPMK-----------------KSMVPVQVQLDVPVVKVASGNDHLVMLTAD 207
Query: 823 EKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGE 882
+ + + GR P +FA Q L RL + R G RG
Sbjct: 208 GDLYTLGCGEQGQLGRVPELFAN----RGGRQGLERLLVPKCVMLKSR-------GSRGH 256
Query: 883 KDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSR 942
VRF CG + + + G VY FG + QLG S
Sbjct: 257 -------------VRFQ------DAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESC 297
Query: 943 GCPTLVQALPGPSTQ---VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
P + + + + G +HT + +G+ ++ G G+LG
Sbjct: 298 FIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 344
Score = 45.4 bits (106), Expect = 0.001
Identities = 44/167 (26%), Positives = 70/167 (41%), Gaps = 28/167 (16%)
Query: 874 KDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQ 933
+D +G G + K + P V+ ++ V+V+ G H V+L +GD+YT G G+ GQ
Sbjct: 164 RDNNGVIGLLEPMKKSMVP---VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQ 220
Query: 934 LGHGD---VNSRGCPTLVQALPGPSTQVTA--------------GSNHTAVLLMDGQVFT 976
LG N G L + L + + G+ T + +G V+
Sbjct: 221 LGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYG 280
Query: 977 FGSFSKGQLGRPILDVPYWNAKPAPMP-NIGSKYGRKATWIGASGDQ 1022
FG + QLG P + +P N+ S +W+G SG Q
Sbjct: 281 FGLSNYHQLGTP-------GTESCFIPQNLTSFKNSTKSWVGFSGGQ 320
Score = 43.9 bits (102), Expect = 0.004
Identities = 33/146 (22%), Positives = 64/146 (43%), Gaps = 15/146 (10%)
Query: 553 GSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSS 612
G H + +++ G ++ G +G G T + P K+ E VV + + +
Sbjct: 93 GMHTVCLSKSGQVYSFGCNDEGALGRDTSV--EGSEMVPGKVELQEK--VVQVSAGDSHT 148
Query: 613 SVISKDGELYMFGKDAIYSDSSSLVTDLKGHFV----------TQVAMGKAHTCVLMKNG 662
+ ++ DG ++++G + L+ +K V +VA G H +L +G
Sbjct: 149 AALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 208
Query: 663 EVWTFGVNNKGQCGRDTGAM-NQGGK 687
+++T G +GQ GR N+GG+
Sbjct: 209 DLYTLGCGEQGQLGRVPELFANRGGR 234
>gi|114796644 regulator of chromosome condensation 1 isoform a [Homo
sapiens]
Length = 452
Score = 53.1 bits (126), Expect = 6e-06
Identities = 34/79 (43%), Positives = 44/79 (55%), Gaps = 5/79 (6%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGC---PTLVQALPGPSTQVTAG 961
VQ G H+V L ++G VY+FG G LG D + G P V+ L QV+AG
Sbjct: 101 VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVE-LQEKVVQVSAG 158
Query: 962 SNHTAVLLMDGQVFTFGSF 980
+HTA L DG+VF +GSF
Sbjct: 159 DSHTAALTDDGRVFLWGSF 177
Score = 52.0 bits (123), Expect = 1e-05
Identities = 48/143 (33%), Positives = 60/143 (41%), Gaps = 27/143 (18%)
Query: 856 LARLRSHPAQLKHKRDKHKDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCG----- 910
+A+ RS PA K K KD + PG+ R+ Q +CG
Sbjct: 6 IAKRRSPPADAIPKSKKVKDTRAAASRR--------VPGA-------RSCQGACGPSPPD 50
Query: 911 -----FHHSVVLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSNH 964
H E G V T G G GQLG G+ V R P LV ++P Q AG H
Sbjct: 51 QKTRPVSHRSHSTEPGLVLTLGQGDVGQLGLGENVMERKKPALV-SIPEDVVQAEAGGMH 109
Query: 965 TAVLLMDGQVFTFGSFSKGQLGR 987
T L GQV++FG +G LGR
Sbjct: 110 TVCLSKSGQVYSFGCNDEGALGR 132
Score = 50.8 bits (120), Expect = 3e-05
Identities = 36/119 (30%), Positives = 58/119 (48%), Gaps = 7/119 (5%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSN 963
V S G HH+V + G Y+ G ++G+LG G+ + PTL+ LP S+ V G++
Sbjct: 328 VGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSS-VACGAS 386
Query: 964 HTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQ 1022
+ DG+VF +G + QLG D W +P+ +G + + +SG Q
Sbjct: 387 VGYAVTKDGRVFAWGMGTNYQLGTG-QDEDAW----SPVEMMGKQLENRVVLSVSSGGQ 440
Score = 46.2 bits (108), Expect = 8e-04
Identities = 80/347 (23%), Positives = 120/347 (34%), Gaps = 93/347 (26%)
Query: 645 VTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEE 704
V Q G HT L K+G+V++FG N++G GRDT
Sbjct: 100 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV----------------------- 136
Query: 705 ELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGE 764
E S M P K +L++ +V GD + A+ GR + GS
Sbjct: 137 ------EGSEMVP---GKVELQEKVVQVSAGD--SHTAALTDDGR-------VFLWGSFR 178
Query: 765 SGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGV-NIEEHL-QLRQE 822
V G + K M+P+ + L VPV V + +HL L +
Sbjct: 179 DNNGVIGLLEPMK-----------------KSMVPVQVQLDVPVVKVASGNDHLVMLTAD 221
Query: 823 EKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGE 882
+ + + GR P +FA Q L RL + R G RG
Sbjct: 222 GDLYTLGCGEQGQLGRVPELFAN----RGGRQGLERLLVPKCVMLKSR-------GSRGH 270
Query: 883 KDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSR 942
VRF CG + + + G VY FG + QLG S
Sbjct: 271 -------------VRFQ------DAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESC 311
Query: 943 GCPTLVQALPGPSTQ---VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
P + + + + G +HT + +G+ ++ G G+LG
Sbjct: 312 FIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 358
Score = 45.4 bits (106), Expect = 0.001
Identities = 44/167 (26%), Positives = 70/167 (41%), Gaps = 28/167 (16%)
Query: 874 KDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQ 933
+D +G G + K + P V+ ++ V+V+ G H V+L +GD+YT G G+ GQ
Sbjct: 178 RDNNGVIGLLEPMKKSMVP---VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQ 234
Query: 934 LGHGD---VNSRGCPTLVQALPGPSTQVTA--------------GSNHTAVLLMDGQVFT 976
LG N G L + L + + G+ T + +G V+
Sbjct: 235 LGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYG 294
Query: 977 FGSFSKGQLGRPILDVPYWNAKPAPMP-NIGSKYGRKATWIGASGDQ 1022
FG + QLG P + +P N+ S +W+G SG Q
Sbjct: 295 FGLSNYHQLGTP-------GTESCFIPQNLTSFKNSTKSWVGFSGGQ 334
Score = 43.9 bits (102), Expect = 0.004
Identities = 33/146 (22%), Positives = 64/146 (43%), Gaps = 15/146 (10%)
Query: 553 GSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSS 612
G H + +++ G ++ G +G G T + P K+ E VV + + +
Sbjct: 107 GMHTVCLSKSGQVYSFGCNDEGALGRDTSV--EGSEMVPGKVELQEK--VVQVSAGDSHT 162
Query: 613 SVISKDGELYMFGKDAIYSDSSSLVTDLKGHFV----------TQVAMGKAHTCVLMKNG 662
+ ++ DG ++++G + L+ +K V +VA G H +L +G
Sbjct: 163 AALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 222
Query: 663 EVWTFGVNNKGQCGRDTGAM-NQGGK 687
+++T G +GQ GR N+GG+
Sbjct: 223 DLYTLGCGEQGQLGRVPELFANRGGR 248
>gi|4502801 regulator of chromosome condensation 1 isoform c [Homo
sapiens]
Length = 421
Score = 53.1 bits (126), Expect = 6e-06
Identities = 34/79 (43%), Positives = 44/79 (55%), Gaps = 5/79 (6%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGC---PTLVQALPGPSTQVTAG 961
VQ G H+V L ++G VY+FG G LG D + G P V+ L QV+AG
Sbjct: 70 VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVE-LQEKVVQVSAG 127
Query: 962 SNHTAVLLMDGQVFTFGSF 980
+HTA L DG+VF +GSF
Sbjct: 128 DSHTAALTDDGRVFLWGSF 146
Score = 50.8 bits (120), Expect = 3e-05
Identities = 36/119 (30%), Positives = 58/119 (48%), Gaps = 7/119 (5%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSN 963
V S G HH+V + G Y+ G ++G+LG G+ + PTL+ LP S+ V G++
Sbjct: 297 VGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSS-VACGAS 355
Query: 964 HTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQ 1022
+ DG+VF +G + QLG D W +P+ +G + + +SG Q
Sbjct: 356 VGYAVTKDGRVFAWGMGTNYQLGTG-QDEDAW----SPVEMMGKQLENRVVLSVSSGGQ 409
Score = 50.1 bits (118), Expect = 5e-05
Identities = 32/70 (45%), Positives = 38/70 (54%), Gaps = 2/70 (2%)
Query: 919 ENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTF 977
E G V T G G GQLG G+ V R P LV ++P Q AG HT L GQV++F
Sbjct: 33 EPGLVLTLGQGDVGQLGLGENVMERKKPALV-SIPEDVVQAEAGGMHTVCLSKSGQVYSF 91
Query: 978 GSFSKGQLGR 987
G +G LGR
Sbjct: 92 GCNDEGALGR 101
Score = 46.2 bits (108), Expect = 8e-04
Identities = 80/347 (23%), Positives = 120/347 (34%), Gaps = 93/347 (26%)
Query: 645 VTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEE 704
V Q G HT L K+G+V++FG N++G GRDT
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV----------------------- 105
Query: 705 ELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGE 764
E S M P K +L++ +V GD + A+ GR + GS
Sbjct: 106 ------EGSEMVP---GKVELQEKVVQVSAGD--SHTAALTDDGR-------VFLWGSFR 147
Query: 765 SGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGV-NIEEHL-QLRQE 822
V G + K M+P+ + L VPV V + +HL L +
Sbjct: 148 DNNGVIGLLEPMK-----------------KSMVPVQVQLDVPVVKVASGNDHLVMLTAD 190
Query: 823 EKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGE 882
+ + + GR P +FA Q L RL + R G RG
Sbjct: 191 GDLYTLGCGEQGQLGRVPELFAN----RGGRQGLERLLVPKCVMLKSR-------GSRGH 239
Query: 883 KDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSR 942
VRF CG + + + G VY FG + QLG S
Sbjct: 240 -------------VRFQ------DAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESC 280
Query: 943 GCPTLVQALPGPSTQ---VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
P + + + + G +HT + +G+ ++ G G+LG
Sbjct: 281 FIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 327
Score = 45.4 bits (106), Expect = 0.001
Identities = 44/167 (26%), Positives = 70/167 (41%), Gaps = 28/167 (16%)
Query: 874 KDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQ 933
+D +G G + K + P V+ ++ V+V+ G H V+L +GD+YT G G+ GQ
Sbjct: 147 RDNNGVIGLLEPMKKSMVP---VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQ 203
Query: 934 LGHGD---VNSRGCPTLVQALPGPSTQVTA--------------GSNHTAVLLMDGQVFT 976
LG N G L + L + + G+ T + +G V+
Sbjct: 204 LGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYG 263
Query: 977 FGSFSKGQLGRPILDVPYWNAKPAPMP-NIGSKYGRKATWIGASGDQ 1022
FG + QLG P + +P N+ S +W+G SG Q
Sbjct: 264 FGLSNYHQLGTP-------GTESCFIPQNLTSFKNSTKSWVGFSGGQ 303
Score = 43.9 bits (102), Expect = 0.004
Identities = 33/146 (22%), Positives = 64/146 (43%), Gaps = 15/146 (10%)
Query: 553 GSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSS 612
G H + +++ G ++ G +G G T + P K+ E VV + + +
Sbjct: 76 GMHTVCLSKSGQVYSFGCNDEGALGRDTSV--EGSEMVPGKVELQEK--VVQVSAGDSHT 131
Query: 613 SVISKDGELYMFGKDAIYSDSSSLVTDLKGHFV----------TQVAMGKAHTCVLMKNG 662
+ ++ DG ++++G + L+ +K V +VA G H +L +G
Sbjct: 132 AALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 663 EVWTFGVNNKGQCGRDTGAM-NQGGK 687
+++T G +GQ GR N+GG+
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGR 217
>gi|114796642 regulator of chromosome condensation 1 [Homo sapiens]
Length = 421
Score = 53.1 bits (126), Expect = 6e-06
Identities = 34/79 (43%), Positives = 44/79 (55%), Gaps = 5/79 (6%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSRGC---PTLVQALPGPSTQVTAG 961
VQ G H+V L ++G VY+FG G LG D + G P V+ L QV+AG
Sbjct: 70 VQAEAGGMHTVCLSKSGQVYSFGCNDEGALGR-DTSVEGSEMVPGKVE-LQEKVVQVSAG 127
Query: 962 SNHTAVLLMDGQVFTFGSF 980
+HTA L DG+VF +GSF
Sbjct: 128 DSHTAALTDDGRVFLWGSF 146
Score = 50.8 bits (120), Expect = 3e-05
Identities = 36/119 (30%), Positives = 58/119 (48%), Gaps = 7/119 (5%)
Query: 905 VQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSN 963
V S G HH+V + G Y+ G ++G+LG G+ + PTL+ LP S+ V G++
Sbjct: 297 VGFSGGQHHTVCMDSEGKAYSLGRAEYGRLGLGEGAEEKSIPTLISRLPAVSS-VACGAS 355
Query: 964 HTAVLLMDGQVFTFGSFSKGQLGRPILDVPYWNAKPAPMPNIGSKYGRKATWIGASGDQ 1022
+ DG+VF +G + QLG D W +P+ +G + + +SG Q
Sbjct: 356 VGYAVTKDGRVFAWGMGTNYQLGTG-QDEDAW----SPVEMMGKQLENRVVLSVSSGGQ 409
Score = 50.1 bits (118), Expect = 5e-05
Identities = 32/70 (45%), Positives = 38/70 (54%), Gaps = 2/70 (2%)
Query: 919 ENGDVYTFGYGQHGQLGHGD-VNSRGCPTLVQALPGPSTQVTAGSNHTAVLLMDGQVFTF 977
E G V T G G GQLG G+ V R P LV ++P Q AG HT L GQV++F
Sbjct: 33 EPGLVLTLGQGDVGQLGLGENVMERKKPALV-SIPEDVVQAEAGGMHTVCLSKSGQVYSF 91
Query: 978 GSFSKGQLGR 987
G +G LGR
Sbjct: 92 GCNDEGALGR 101
Score = 46.2 bits (108), Expect = 8e-04
Identities = 80/347 (23%), Positives = 120/347 (34%), Gaps = 93/347 (26%)
Query: 645 VTQVAMGKAHTCVLMKNGEVWTFGVNNKGQCGRDTGAMNQGGKGFGVENMATAMDEDLEE 704
V Q G HT L K+G+V++FG N++G GRDT
Sbjct: 69 VVQAEAGGMHTVCLSKSGQVYSFGCNDEGALGRDTSV----------------------- 105
Query: 705 ELDEKDEKSMMCPPGMHKWKLEQCMVCTVCGDCTGYGASCVSSGRPDRVPGGICGCGSGE 764
E S M P K +L++ +V GD + A+ GR + GS
Sbjct: 106 ------EGSEMVP---GKVELQEKVVQVSAGD--SHTAALTDDGR-------VFLWGSFR 147
Query: 765 SGCAVCGCCKACARELDGQEARQRGILDAVKEMIPLDLLLAVPVPGV-NIEEHL-QLRQE 822
V G + K M+P+ + L VPV V + +HL L +
Sbjct: 148 DNNGVIGLLEPMK-----------------KSMVPVQVQLDVPVVKVASGNDHLVMLTAD 190
Query: 823 EKRQRVIRRHRLEEGRGPLVFAGPIFMNHREQALARLRSHPAQLKHKRDKHKDGSGERGE 882
+ + + GR P +FA Q L RL + R G RG
Sbjct: 191 GDLYTLGCGEQGQLGRVPELFAN----RGGRQGLERLLVPKCVMLKSR-------GSRGH 239
Query: 883 KDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQLGHGDVNSR 942
VRF CG + + + G VY FG + QLG S
Sbjct: 240 -------------VRFQ------DAFCGAYFTFAISHEGHVYGFGLSNYHQLGTPGTESC 280
Query: 943 GCPTLVQALPGPSTQ---VTAGSNHTAVLLMDGQVFTFGSFSKGQLG 986
P + + + + G +HT + +G+ ++ G G+LG
Sbjct: 281 FIPQNLTSFKNSTKSWVGFSGGQHHTVCMDSEGKAYSLGRAEYGRLG 327
Score = 45.4 bits (106), Expect = 0.001
Identities = 44/167 (26%), Positives = 70/167 (41%), Gaps = 28/167 (16%)
Query: 874 KDGSGERGEKDASKITTYPPGSVRFDCELRAVQVSCGFHHSVVLMENGDVYTFGYGQHGQ 933
+D +G G + K + P V+ ++ V+V+ G H V+L +GD+YT G G+ GQ
Sbjct: 147 RDNNGVIGLLEPMKKSMVP---VQVQLDVPVVKVASGNDHLVMLTADGDLYTLGCGEQGQ 203
Query: 934 LGHGD---VNSRGCPTLVQALPGPSTQVTA--------------GSNHTAVLLMDGQVFT 976
LG N G L + L + + G+ T + +G V+
Sbjct: 204 LGRVPELFANRGGRQGLERLLVPKCVMLKSRGSRGHVRFQDAFCGAYFTFAISHEGHVYG 263
Query: 977 FGSFSKGQLGRPILDVPYWNAKPAPMP-NIGSKYGRKATWIGASGDQ 1022
FG + QLG P + +P N+ S +W+G SG Q
Sbjct: 264 FGLSNYHQLGTP-------GTESCFIPQNLTSFKNSTKSWVGFSGGQ 303
Score = 43.9 bits (102), Expect = 0.004
Identities = 33/146 (22%), Positives = 64/146 (43%), Gaps = 15/146 (10%)
Query: 553 GSHALLVAEDGSIFFTGSASKGEDGESTKSRRQSKPYKPKKIIKMEGKIVVYTACNNGSS 612
G H + +++ G ++ G +G G T + P K+ E VV + + +
Sbjct: 76 GMHTVCLSKSGQVYSFGCNDEGALGRDTSV--EGSEMVPGKVELQEK--VVQVSAGDSHT 131
Query: 613 SVISKDGELYMFGKDAIYSDSSSLVTDLKGHFV----------TQVAMGKAHTCVLMKNG 662
+ ++ DG ++++G + L+ +K V +VA G H +L +G
Sbjct: 132 AALTDDGRVFLWGSFRDNNGVIGLLEPMKKSMVPVQVQLDVPVVKVASGNDHLVMLTADG 191
Query: 663 EVWTFGVNNKGQCGRDTGAM-NQGGK 687
+++T G +GQ GR N+GG+
Sbjct: 192 DLYTLGCGEQGQLGRVPELFANRGGR 217
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.132 0.395
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 188,658,478
Number of Sequences: 37866
Number of extensions: 9199210
Number of successful extensions: 44181
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 67
Number of HSP's successfully gapped in prelim test: 574
Number of HSP's that attempted gapping in prelim test: 38955
Number of HSP's gapped (non-prelim): 5351
length of query: 4640
length of database: 18,247,518
effective HSP length: 124
effective length of query: 4516
effective length of database: 13,552,134
effective search space: 61201437144
effective search space used: 61201437144
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 73 (32.7 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.