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Search of human proteins with 40316935
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|40316935 alsin isoform 1 [Homo sapiens]
(1657 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|40316935 alsin isoform 1 [Homo sapiens] 3347 0.0
gi|209364523 alsin isoform 2 [Homo sapiens] 746 0.0
gi|33359215 ALS2 C-terminal like isoform 1 [Homo sapiens] 508 e-143
gi|33359217 ALS2 C-terminal like isoform 3 [Homo sapiens] 188 4e-47
gi|153792461 radial spoke head 10 homolog B2 [Homo sapiens] 98 8e-20
gi|157502187 radial spoke head 10 homolog B [Homo sapiens] 98 8e-20
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 89 4e-17
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 89 4e-17
gi|126032348 hect domain and RLD 2 [Homo sapiens] 89 5e-17
gi|7657152 hect domain and RLD 3 [Homo sapiens] 89 5e-17
gi|61563742 hect domain and RLD 6 [Homo sapiens] 86 4e-16
gi|18254456 testis-specific gene A2 [Homo sapiens] 83 2e-15
gi|57242759 regulator of chromosome condensation (RCC1) and BTB ... 82 3e-15
gi|13376267 MORN repeat containing 1 [Homo sapiens] 81 1e-14
gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens] 79 4e-14
gi|50355990 MORN repeat containing 3 [Homo sapiens] 74 9e-13
gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo... 74 2e-12
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 74 2e-12
gi|110825982 hect domain and RLD 5 [Homo sapiens] 73 3e-12
gi|209969703 regulator of chromosome condensation 2 [Homo sapiens] 72 3e-12
gi|29789090 regulator of chromosome condensation 2 [Homo sapiens] 72 3e-12
gi|4557445 regulator of chromosome condensation and BTB domain c... 72 4e-12
gi|30039692 NIMA-related kinase 8 [Homo sapiens] 70 1e-11
gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo ... 68 6e-11
gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo s... 68 8e-11
gi|21704281 junctophilin 2 isoform 1 [Homo sapiens] 68 8e-11
gi|21704283 junctophilin 3 [Homo sapiens] 67 1e-10
gi|63054860 RCC1 domain containing 1 [Homo sapiens] 66 2e-10
gi|63054858 RCC1 domain containing 1 [Homo sapiens] 66 2e-10
gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo s... 64 1e-09
>gi|40316935 alsin isoform 1 [Homo sapiens]
Length = 1657
Score = 3347 bits (8678), Expect = 0.0
Identities = 1657/1657 (100%), Positives = 1657/1657 (100%)
Query: 1 MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 60
MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG
Sbjct: 1 MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 60
Query: 61 EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120
EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA
Sbjct: 61 EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120
Query: 121 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 180
GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL
Sbjct: 121 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 180
Query: 181 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 240
GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI
Sbjct: 181 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 240
Query: 241 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 300
TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS
Sbjct: 241 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 300
Query: 301 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 360
VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED
Sbjct: 301 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 360
Query: 361 SEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK 420
SEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK
Sbjct: 361 SEHGEKPVPSQPLLEEAIPNLHSPPTTSTSALNSLVVSCASAVGVRVAATYEAGALSLKK 420
Query: 421 VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR 480
VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR
Sbjct: 421 VMNFYSTTPCETGAQAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR 480
Query: 481 RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 540
RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG
Sbjct: 481 RLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 540
Query: 541 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV 600
HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV
Sbjct: 541 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV 600
Query: 601 PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV 660
PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV
Sbjct: 601 PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPV 660
Query: 661 LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL 720
LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL
Sbjct: 661 LLSCSKLGYISRVTAGKDSYLALVDKNIMGYIASLHELATTERRFYSKLSDIKSQILRPL 720
Query: 721 LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD 780
LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD
Sbjct: 721 LSLENLGTTTTVQLLQEVASRFSKLCYLIGQHGASLSSFLHGVKEARSLVILKHSSLFLD 780
Query: 781 SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP 840
SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP
Sbjct: 781 SYTEYCTSITNFLVMGGFQLLAKPAIDFLNKNQELLQDLSEVNDENTQLMEILNTLFFLP 840
Query: 841 IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP 900
IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP
Sbjct: 841 IRRLHNYAKVLLKLATCFEVASPEYQKLQDSSSCYECLALHLGRKRKEAEYTLGFWKTFP 900
Query: 901 GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW 960
GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW
Sbjct: 901 GKMTDSLRKPERRLLCESSNRALSLQHAGRFSVNWFILFNDALVHAQFSTHHVFPLATLW 960
Query: 961 AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG 1020
AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG
Sbjct: 961 AEPLSEEAGGVNGLKITTPEEQFTLISSTPQEKTKWLRAISQAVDQALRGMSDLPPYGSG 1020
Query: 1021 SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL 1080
SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL
Sbjct: 1021 SSVQRQEPPISRSAKYTFYKDPRLKDATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGL 1080
Query: 1081 EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS 1140
EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS
Sbjct: 1081 EDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS 1140
Query: 1141 GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG 1200
GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG
Sbjct: 1141 GKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEG 1200
Query: 1201 NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT 1260
NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT
Sbjct: 1201 NFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKIT 1260
Query: 1261 GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN 1320
GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN
Sbjct: 1261 GTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVFDECWRQLGCEGPGQGEVWKAWDN 1320
Query: 1321 IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL 1380
IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL
Sbjct: 1321 IAVALTTSRRQHRDSPEILSRSQTQTLESLEFIPQHVGAFSVEKYDDIRKYLIKACDTPL 1380
Query: 1381 HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI 1440
HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI
Sbjct: 1381 HPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTI 1440
Query: 1441 PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE 1500
PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE
Sbjct: 1441 PLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDRE 1500
Query: 1501 EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ 1560
EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ
Sbjct: 1501 EDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQ 1560
Query: 1561 QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE 1620
QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE
Sbjct: 1561 QISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSE 1620
Query: 1621 VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN 1657
VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN
Sbjct: 1621 VHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKLN 1657
>gi|209364523 alsin isoform 2 [Homo sapiens]
Length = 396
Score = 746 bits (1927), Expect = 0.0
Identities = 371/371 (100%), Positives = 371/371 (100%)
Query: 1 MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 60
MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG
Sbjct: 1 MDSKKRSSTEAEGSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDG 60
Query: 61 EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120
EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA
Sbjct: 61 EVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120
Query: 121 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 180
GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL
Sbjct: 121 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQL 180
Query: 181 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 240
GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI
Sbjct: 181 GLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQCSQLLI 240
Query: 241 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 300
TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS
Sbjct: 241 TMTDKEDHVIISDSHCCPLGVTLTESQAENHASTALSPSTETLDRQEEVFENTLVANDQS 300
Query: 301 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 360
VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED
Sbjct: 301 VATELNAVSAQITSSDAMSSQQNVMGTTEISSARNIPSYPDTQAVNEYLRKLSDHSVRED 360
Query: 361 SEHGEKPVPSQ 371
SEHGEKPVPSQ
Sbjct: 361 SEHGEKPVPSQ 371
Score = 45.8 bits (107), Expect = 3e-04
Identities = 51/209 (24%), Positives = 84/209 (40%), Gaps = 15/209 (7%)
Query: 435 QAGSSAIGPEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSRRLSLPGLLSQVSPR 494
QAGS I PE L + V Q ++ K L + E + G S P + SP
Sbjct: 24 QAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPI 83
Query: 495 LLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQ--LGHGDVLPRLQPLC 552
L TV +SG + WG+ GQ + + +P P+
Sbjct: 84 LENALVGQYVITVATGSFHSGAVTD-----NGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
Query: 553 VKCLDGK-----EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKIS 607
+ + ++ L G H+LAL+ ++++WG+ L + FP T P+ +
Sbjct: 139 IADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHL 198
Query: 608 SENGVWSIAAGRDYSLFLVD---TEDFQP 633
+ V +A G +SL LV ++D +P
Sbjct: 199 AGRVVLQVACGAFHSLALVQCLPSQDLKP 227
>gi|33359215 ALS2 C-terminal like isoform 1 [Homo sapiens]
Length = 953
Score = 508 bits (1309), Expect = e-143
Identities = 330/977 (33%), Positives = 508/977 (51%), Gaps = 65/977 (6%)
Query: 698 LATTERRFYSKLSDIKSQILRPLLSL----ENLGTTTTVQLLQEVASRFSKLCYLIGQHG 753
L E F + L+ + S +L+PLL + ++LLQ++ +L + +
Sbjct: 9 LLRLEEVFSATLAHVNSLVLQPLLPAAPDPSDPWGRECLRLLQQLHKSSQQLWEVTEESL 68
Query: 754 ASLSSFLHGVKEA--RSLVILKHSSLFLDSYTEYCTSITNFLVMGGFQLLAKPAIDFLNK 811
SL L SL++L+ + L ++ EY S T+ +V+ FQ AK ++
Sbjct: 69 HSLQERLRYPDSTGLESLLLLRGADRVLQAHIEYIESYTSCMVVQAFQKAAKRRSEYWRG 128
Query: 812 NQELLQDL-SEVNDENTQLMEILNTLFFLPIRRLHNYAKVLLKLATCFEVASPEYQKLQD 870
++ L+ L S V+ E + + L + Y +LL L P + + +
Sbjct: 129 QRKALRQLLSGVSSEGSVGASLGQALHQPLAHHVQQYVLLLLSLGDTIGEHHPTRELVVN 188
Query: 871 SSSCYECLALHLGRKRKEAEYTLGFWKTFPGKMTDSLRKPERRLLCESSNRALSLQHAGR 930
+ + + L + ++ +A T W T G++ D L P RLL +S + +++
Sbjct: 189 AVTLFGNLQSFMKQELDQAVATQALWHTLRGRLRDVLCTPAHRLLQDSQDVPVTVAPLRA 248
Query: 931 FSVNWFILFNDALVHAQFSTHHVFPLATLWAEPLSEEAGGVNG--LKITTPEEQFTLISS 988
V +LF+DALV Q H F L +W +P G +G + TPEE+F+ +
Sbjct: 249 ERV---LLFDDALVLLQGHNVHTFDLKLVWVDP------GQDGCTFHLLTPEEEFSFCAK 299
Query: 989 TPQEKTKWLRAISQAVDQALRGMSDLPPYGSGSSVQRQEPPISRSAKYTFYKDPRLKDAT 1048
Q + W ++ AV QAL G D P G+G ++ +PP R A+YTF + RL AT
Sbjct: 300 DSQGQAVWQWKVTWAVHQALHGKKDFPVLGAG--LEPSQPPDCRCAEYTFQAEGRLCQAT 357
Query: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGK 1108
Y+G W G+PHG+G LKWPDG+ + G F GLE G+G +P + +K D Y HW+EG
Sbjct: 358 YEGEWCRGRPHGKGTLKWPDGRNHVGNFCQGLEHGFGIRLLPQASEDKFDCYKCHWREGS 417
Query: 1109 MCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDD 1168
MCG G+ Y++ EV++G FQ+ +RHG G+L SG + P + G W +++GYG+ +D
Sbjct: 418 MCGYGICEYSTDEVYKGYFQEGLRHGFGVLESGP-QAPQPFRYTGHWERGQRSGYGIEED 476
Query: 1169 ITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDD 1228
RGE+Y+GMWQ G GV+VTQ G+ Y+G F +K +G G+LLSEDD++YEG F+ D
Sbjct: 477 GDRGERYIGMWQAGQRHGPGVMVTQAGVCYQGTFQADKTVGPGILLSEDDSLYEGTFTRD 536
Query: 1229 WTLSGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKPSLYESDKDRPKVFRKLGNLAVP 1288
TL GKG +T PNG +EG F G G+ G +L K R+LG A P
Sbjct: 537 LTLMGKGKVTFPNGFTLEGSFGSGAGRGLHTQGVLDTAALPPDPSSTCK--RQLGVGAFP 594
Query: 1289 ADEKWKAVFDECWRQLGCEGPGQG--EVWKAWDNIAVALTTSRRQHRDSPEILSRSQTQT 1346
+ +W+ V+ +R C G + E +D S R+ R S + LS +T
Sbjct: 595 VESRWQGVYSP-FRDFVCAGCPRDLQEALLGFD------VQSSRELRRSQDYLSCERTHP 647
Query: 1347 LES-------LEFIPQHVGAFSVEKYDDIRKYLIKACDTPLHPLGRLVETLVAVYRMTYV 1399
+S LE + QH + ++ YL KA LHPLG+L+ TL+ ++ TY
Sbjct: 648 EDSVGSMEDILEELLQH------REPKALQLYLRKALSNSLHPLGKLLRTLMLTFQATYA 701
Query: 1400 GVGANRRLLQEAVKEIKSYLKRIFQLVRFLFPELPEEGSTIPLSAPLPTERKSFCTGKSD 1459
GVGAN+ L + A +E+K + + ++ R L + ERK + D
Sbjct: 702 GVGANKHLQELAQEEVKQHAQELWAAYRGLL--------------RVALERKGQAL-EED 746
Query: 1460 SRSESPEPGYVVTSSGLLLPVLLPRLYPPLFMLYALDNDREEDIYWECVLRLNKQPDIAL 1519
+E+ + + GL+LP++LP Y LF LY L ++RE+ Y + + L+ PD L
Sbjct: 747 EDTETRD----LQVHGLVLPLMLPSFYSELFTLYLLLHEREDSFYSQGIANLSLFPDTQL 802
Query: 1520 LGFLGVQRKFWPATLSILGESKKVLPTTKDACFASAVECLQQISTTFTPSDKLKVIQQTF 1579
L FL VQ+ WP L +++ +D CF SA ECLQ+I TT P +KL+V+++T+
Sbjct: 803 LEFLDVQKHLWPLKDLTLTSNQR-YSLVRDKCFLSATECLQKIMTTVDPREKLEVLERTY 861
Query: 1580 EEISQSVLASLHEDFLWSMDDLFPVFLYVVLRARIRNLGSEVHLIEDLMDPYLQHGEQGI 1639
EI +V L ++ MDDL P+ +YVV RARI++LG+E+HLI D+MDP G
Sbjct: 862 GEIEGTVSRVLGREYKLPMDDLLPLLIYVVSRARIQHLGAEIHLIRDMMDPNHTGGLYDF 921
Query: 1640 MFTTLKACYYQIQREKL 1656
+ T L++CY IQ+E +
Sbjct: 922 LLTALESCYEHIQKEDM 938
>gi|33359217 ALS2 C-terminal like isoform 3 [Homo sapiens]
Length = 300
Score = 188 bits (477), Expect = 4e-47
Identities = 108/289 (37%), Positives = 165/289 (57%), Gaps = 20/289 (6%)
Query: 1368 IRKYLIKACDTPLHPLGRLVETLVAVYRMTYVGVGANRRLLQEAVKEIKSYLKRIFQLVR 1427
++ YL KA LHPLG+L+ TL+ ++ TY GVGAN+ L + A +E+K + + ++ R
Sbjct: 17 LQLYLRKALSNSLHPLGKLLRTLMLTFQATYAGVGANKHLQELAQEEVKQHAQELWAAYR 76
Query: 1428 FLFPELPEEGSTIPLSAPLPTERKSFCTGKSDSRSESPEPGYVVTSSGLLLPVLLPRLYP 1487
L + ERK + D +E+ + + GL+LP++LP Y
Sbjct: 77 GLLR--------------VALERKGQAL-EEDEDTETRD----LQVHGLVLPLMLPSFYS 117
Query: 1488 PLFMLYALDNDREEDIYWECVLRLNKQPDIALLGFLGVQRKFWPATLSILGESKKVLPTT 1547
LF LY L ++RE+ Y + + L+ PD LL FL VQ+ WP L +++
Sbjct: 118 ELFTLYLLLHEREDSFYSQGIANLSLFPDTQLLEFLDVQKHLWPLKDLTLTSNQRY-SLV 176
Query: 1548 KDACFASAVECLQQISTTFTPSDKLKVIQQTFEEISQSVLASLHEDFLWSMDDLFPVFLY 1607
+D CF SA ECLQ+I TT P +KL+V+++T+ EI +V L ++ MDDL P+ +Y
Sbjct: 177 RDKCFLSATECLQKIMTTVDPREKLEVLERTYGEIEGTVSRVLGREYKLPMDDLLPLLIY 236
Query: 1608 VVLRARIRNLGSEVHLIEDLMDPYLQHGEQGIMFTTLKACYYQIQREKL 1656
VV RARI++LG+E+HLI D+MDP G + T L++CY IQ+E +
Sbjct: 237 VVSRARIQHLGAEIHLIRDMMDPNHTGGLYDFLLTALESCYEHIQKEDM 285
>gi|153792461 radial spoke head 10 homolog B2 [Homo sapiens]
Length = 870
Score = 97.8 bits (242), Expect = 8e-20
Identities = 61/214 (28%), Positives = 96/214 (44%), Gaps = 42/214 (19%)
Query: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGK 1108
Y+G ++ P GV WPDG MY G NG+ +G+G ++ + ++ Y+GHW GK
Sbjct: 132 YEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQPVS----YIGHWCNGK 187
Query: 1109 MCGQ-------------------------GVYSYASGEVFEGCFQDNMRHGHGLLRSGKL 1143
G+ G+ Y SG ++EG ++DNMRHG G +R L
Sbjct: 188 RHGKGSIYYNQEGTCWYEGDWVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMR--WL 245
Query: 1144 TSSSPSMFIGQWVMDKKAGYGVF---------DDITRGEKYMGMWQDDVCQGNGVVVTQF 1194
T++ + G+W + G+G +Y+G + + G G
Sbjct: 246 TTNEE--YTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYAS 303
Query: 1195 GLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDD 1228
G Y+G + NK G G L ++ +YEG FS+D
Sbjct: 304 GAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSND 337
Score = 42.7 bits (99), Expect = 0.003
Identities = 28/82 (34%), Positives = 38/82 (46%), Gaps = 1/82 (1%)
Query: 1143 LTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNF 1202
LT + G+ V G G F G Y GM+ + + G G + GL YEG+F
Sbjct: 78 LTKLIVESYEGEKVRGLYEGEG-FAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDF 136
Query: 1203 HLNKMMGNGVLLSEDDTIYEGE 1224
N M +GV D ++YEGE
Sbjct: 137 VKNVPMNHGVYTWPDGSMYEGE 158
Score = 41.6 bits (96), Expect = 0.006
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 1047 ATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRI 1089
A YDG W+S K HG G L + +G++Y G F N G+ + +
Sbjct: 305 AMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGFPDLEV 347
Score = 39.3 bits (90), Expect = 0.032
Identities = 25/76 (32%), Positives = 34/76 (44%), Gaps = 6/76 (7%)
Query: 1172 GEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTL 1231
GEK G+++ G G Q G Y G F M G G + D YEG+F + +
Sbjct: 88 GEKVRGLYE-----GEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPM 142
Query: 1232 SGKGTLTMPNGDYIEG 1247
+ G T P+G EG
Sbjct: 143 N-HGVYTWPDGSMYEG 157
>gi|157502187 radial spoke head 10 homolog B [Homo sapiens]
Length = 870
Score = 97.8 bits (242), Expect = 8e-20
Identities = 61/214 (28%), Positives = 96/214 (44%), Gaps = 42/214 (19%)
Query: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGK 1108
Y+G ++ P GV WPDG MY G NG+ +G+G ++ + ++ Y+GHW GK
Sbjct: 132 YEGDFVKNVPMNHGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQPVS----YIGHWCNGK 187
Query: 1109 MCGQ-------------------------GVYSYASGEVFEGCFQDNMRHGHGLLRSGKL 1143
G+ G+ Y SG ++EG ++DNMRHG G +R L
Sbjct: 188 RHGKGSIYYNQEGTCWYEGDWVQNIKKGWGIRCYKSGNIYEGQWEDNMRHGEGRMR--WL 245
Query: 1144 TSSSPSMFIGQWVMDKKAGYGVF---------DDITRGEKYMGMWQDDVCQGNGVVVTQF 1194
T++ + G+W + G+G +Y+G + + G G
Sbjct: 246 TTNEE--YTGRWERGIQNGFGTHTWFLKRIRSSQYPLRNEYIGEFVNGYRHGRGKFYYAS 303
Query: 1195 GLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDD 1228
G Y+G + NK G G L ++ +YEG FS+D
Sbjct: 304 GAMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSND 337
Score = 57.4 bits (137), Expect = 1e-07
Identities = 47/183 (25%), Positives = 77/183 (42%), Gaps = 28/183 (15%)
Query: 1098 DHYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGL------------------LR 1139
+ Y G G G+G ++ G + G F + + HG G +
Sbjct: 84 ESYEGEKVRGLYEGEGFAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDFVKNVPMN 143
Query: 1140 SGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNG-VVVTQFG-LY 1197
G T SM+ G+ V + G+G+F T+ Y+G W + G G + Q G +
Sbjct: 144 HGVYTWPDGSMYEGEVVNGMRNGFGMFKCSTQPVSYIGHWCNGKRHGKGSIYYNQEGTCW 203
Query: 1198 YEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTL--TMPNGDYIEGYFSGEWGS 1255
YEG++ N G G+ + IYEG++ D+ G+G + N +Y +G W
Sbjct: 204 YEGDWVQNIKKGWGIRCYKSGNIYEGQWEDNMR-HGEGRMRWLTTNEEY-----TGRWER 257
Query: 1256 GIK 1258
GI+
Sbjct: 258 GIQ 260
Score = 42.7 bits (99), Expect = 0.003
Identities = 28/82 (34%), Positives = 38/82 (46%), Gaps = 1/82 (1%)
Query: 1143 LTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNF 1202
LT + G+ V G G F G Y GM+ + + G G + GL YEG+F
Sbjct: 78 LTKLIVESYEGEKVRGLYEGEG-FAAFQGGCTYRGMFSEGLMHGQGTYIWADGLKYEGDF 136
Query: 1203 HLNKMMGNGVLLSEDDTIYEGE 1224
N M +GV D ++YEGE
Sbjct: 137 VKNVPMNHGVYTWPDGSMYEGE 158
Score = 41.6 bits (96), Expect = 0.006
Identities = 17/43 (39%), Positives = 25/43 (58%)
Query: 1047 ATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRI 1089
A YDG W+S K HG G L + +G++Y G F N G+ + +
Sbjct: 305 AMYDGEWVSNKKHGMGRLTFKNGRVYEGAFSNDHIAGFPDLEV 347
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 89.0 bits (219), Expect = 4e-17
Identities = 63/191 (32%), Positives = 94/191 (49%), Gaps = 12/191 (6%)
Query: 30 ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALV 89
+ P + + K V G++H V + +DG VY+ G E P AL
Sbjct: 23 LEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALD 82
Query: 90 GQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCA-VANQQYVPEP-NPVSIADSEASPL 147
Q ++ V+ G H+ A+ D G Y WG +S GQ V +++ + P N S++D
Sbjct: 83 AQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSD------ 136
Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQ 205
++I+Q+ACG H+LALS + E++ WG QLGL T T PQ ++ L G +Q
Sbjct: 137 --IQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQ 194
Query: 206 VACGAFHSLAL 216
VA G HS L
Sbjct: 195 VAAGGAHSFVL 205
Score = 80.9 bits (198), Expect = 1e-14
Identities = 59/193 (30%), Positives = 96/193 (49%), Gaps = 17/193 (8%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP--SSPILENAL 88
P + ++Q A G H + L++ EV+ +G + + G C +SP L +L
Sbjct: 128 PRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSL 187
Query: 89 VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAV--ANQQYVPEPNPVSIADSEASP 146
+G + VA G HS +T +G + WG N GQ + N +YVP +
Sbjct: 188 LGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP---------NLLKS 238
Query: 147 LLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVL 204
L + +I+ + CGE+HT AL+ ++ +G G QLG +T+ + P+KV L G +V
Sbjct: 239 LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEI-NPRKVFELMGSIVT 297
Query: 205 QVACGAFHSLALV 217
++ACG H+ A V
Sbjct: 298 EIACGRQHTSAFV 310
Score = 66.6 bits (161), Expect = 2e-10
Identities = 42/113 (37%), Positives = 56/113 (49%), Gaps = 2/113 (1%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGHG-DVLPRLQPLCVKCLDGKEVIHLEAGGYHSLA 573
G +L S +EV+ WG+ K GQLG G D + P +K L G + + AGG HS
Sbjct: 145 GYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFV 204
Query: 574 LTAKSQVYSWGSNTFGQLGHSD-FPTTVPRLAKISSENGVWSIAAGRDYSLFL 625
LT ++ WG N FGQLG +D VP L K + I G D++ L
Sbjct: 205 LTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Score = 62.4 bits (150), Expect = 4e-09
Identities = 50/197 (25%), Positives = 87/197 (44%), Gaps = 22/197 (11%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-LPWRSGPV--EICPSSPILENAL 88
PE++ + ++ + G H + L + G+VY++G + G V E C P +L
Sbjct: 75 PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
Query: 89 VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP-- 146
++ VA G +HS A++ + WG+N GQ + + SP
Sbjct: 135 SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD-----------CKKQTSPQL 183
Query: 147 ---LLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGR 201
LL + +Q+A G H+ L++S I+ WG QLGL P ++ L +
Sbjct: 184 LKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-NDENDRYVPNLLKSLRSQ 242
Query: 202 VVLQVACGAFHSLALVQ 218
++ + CG H+ AL +
Sbjct: 243 KIVYICCGEDHTAALTK 259
Score = 62.4 bits (150), Expect = 4e-09
Identities = 40/134 (29%), Positives = 69/134 (51%), Gaps = 6/134 (4%)
Query: 490 QVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQ 549
Q SP+LL+ + V +G A + + +L ++ WG+ K GQLG D R
Sbjct: 178 QTSPQLLKSLLGIPFMQVA-----AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYV 232
Query: 550 PLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV-PRLAKISS 608
P +K L ++++++ G H+ ALT + V+++G+ +GQLGH+ + PR
Sbjct: 233 PNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELM 292
Query: 609 ENGVWSIAAGRDYS 622
+ V IA GR ++
Sbjct: 293 GSIVTEIACGRQHT 306
Score = 60.1 bits (144), Expect = 2e-08
Identities = 40/114 (35%), Positives = 57/114 (50%), Gaps = 3/114 (2%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGH-GDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLA 573
GEA L + + +V+ WG +GQLG G P +K L +++ + G YHSLA
Sbjct: 92 GEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLA 151
Query: 574 LTAKSQVYSWGSNTFGQLGHSD--FPTTVPRLAKISSENGVWSIAAGRDYSLFL 625
L+ S+V+ WG N +GQLG T P+L K +AAG +S L
Sbjct: 152 LSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 205
Score = 57.8 bits (138), Expect = 9e-08
Identities = 39/100 (39%), Positives = 54/100 (54%), Gaps = 4/100 (4%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
V+T G GQLGH R +P V LD + ++ + G H+LAL K QVY+WG ++
Sbjct: 55 VYTCGCNDLGQLGHEK--SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112
Query: 588 FGQLG--HSDFPTTVPRLAKISSENGVWSIAAGRDYSLFL 625
GQLG S+ VPR K S+ + +A G +SL L
Sbjct: 113 DGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLAL 152
Score = 40.4 bits (93), Expect = 0.014
Identities = 25/66 (37%), Positives = 33/66 (50%), Gaps = 1/66 (1%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKS-QVYSWGSN 586
V+T+G G GQLGH + P V L G V + G H+ A S ++YS+G
Sbjct: 263 VFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLG 322
Query: 587 TFGQLG 592
GQLG
Sbjct: 323 GNGQLG 328
Score = 39.3 bits (90), Expect = 0.032
Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
Query: 531 WGKGKEGQLGHGDVLPR--LQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTF 588
WG GQLG G + L+P K V + G H++ + VY+ G N
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 589 GQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVD 627
GQLGH ++ + ++N + +++ G ++L L D
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQN-IVAVSCGEAHTLALND 101
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 89.0 bits (219), Expect = 4e-17
Identities = 63/191 (32%), Positives = 94/191 (49%), Gaps = 12/191 (6%)
Query: 30 ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALV 89
+ P + + K V G++H V + +DG VY+ G E P AL
Sbjct: 23 LEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALD 82
Query: 90 GQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCA-VANQQYVPEP-NPVSIADSEASPL 147
Q ++ V+ G H+ A+ D G Y WG +S GQ V +++ + P N S++D
Sbjct: 83 AQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSD------ 136
Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQ 205
++I+Q+ACG H+LALS + E++ WG QLGL T T PQ ++ L G +Q
Sbjct: 137 --IQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQ 194
Query: 206 VACGAFHSLAL 216
VA G HS L
Sbjct: 195 VAAGGAHSFVL 205
Score = 80.9 bits (198), Expect = 1e-14
Identities = 59/193 (30%), Positives = 96/193 (49%), Gaps = 17/193 (8%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICP--SSPILENAL 88
P + ++Q A G H + L++ EV+ +G + + G C +SP L +L
Sbjct: 128 PRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSL 187
Query: 89 VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAV--ANQQYVPEPNPVSIADSEASP 146
+G + VA G HS +T +G + WG N GQ + N +YVP +
Sbjct: 188 LGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVP---------NLLKS 238
Query: 147 LLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVL 204
L + +I+ + CGE+HT AL+ ++ +G G QLG +T+ + P+KV L G +V
Sbjct: 239 LRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEI-NPRKVFELMGSIVT 297
Query: 205 QVACGAFHSLALV 217
++ACG H+ A V
Sbjct: 298 EIACGRQHTSAFV 310
Score = 66.6 bits (161), Expect = 2e-10
Identities = 42/113 (37%), Positives = 56/113 (49%), Gaps = 2/113 (1%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGHG-DVLPRLQPLCVKCLDGKEVIHLEAGGYHSLA 573
G +L S +EV+ WG+ K GQLG G D + P +K L G + + AGG HS
Sbjct: 145 GYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFV 204
Query: 574 LTAKSQVYSWGSNTFGQLGHSD-FPTTVPRLAKISSENGVWSIAAGRDYSLFL 625
LT ++ WG N FGQLG +D VP L K + I G D++ L
Sbjct: 205 LTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAAL 257
Score = 62.4 bits (150), Expect = 4e-09
Identities = 50/197 (25%), Positives = 87/197 (44%), Gaps = 22/197 (11%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-LPWRSGPV--EICPSSPILENAL 88
PE++ + ++ + G H + L + G+VY++G + G V E C P +L
Sbjct: 75 PEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSL 134
Query: 89 VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP-- 146
++ VA G +HS A++ + WG+N GQ + + SP
Sbjct: 135 SDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTD-----------CKKQTSPQL 183
Query: 147 ---LLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGR 201
LL + +Q+A G H+ L++S I+ WG QLGL P ++ L +
Sbjct: 184 LKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGL-NDENDRYVPNLLKSLRSQ 242
Query: 202 VVLQVACGAFHSLALVQ 218
++ + CG H+ AL +
Sbjct: 243 KIVYICCGEDHTAALTK 259
Score = 62.4 bits (150), Expect = 4e-09
Identities = 40/134 (29%), Positives = 69/134 (51%), Gaps = 6/134 (4%)
Query: 490 QVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQ 549
Q SP+LL+ + V +G A + + +L ++ WG+ K GQLG D R
Sbjct: 178 QTSPQLLKSLLGIPFMQVA-----AGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYV 232
Query: 550 PLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV-PRLAKISS 608
P +K L ++++++ G H+ ALT + V+++G+ +GQLGH+ + PR
Sbjct: 233 PNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFELM 292
Query: 609 ENGVWSIAAGRDYS 622
+ V IA GR ++
Sbjct: 293 GSIVTEIACGRQHT 306
Score = 60.1 bits (144), Expect = 2e-08
Identities = 40/114 (35%), Positives = 57/114 (50%), Gaps = 3/114 (2%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGH-GDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLA 573
GEA L + + +V+ WG +GQLG G P +K L +++ + G YHSLA
Sbjct: 92 GEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLA 151
Query: 574 LTAKSQVYSWGSNTFGQLGHSD--FPTTVPRLAKISSENGVWSIAAGRDYSLFL 625
L+ S+V+ WG N +GQLG T P+L K +AAG +S L
Sbjct: 152 LSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGAHSFVL 205
Score = 57.8 bits (138), Expect = 9e-08
Identities = 39/100 (39%), Positives = 54/100 (54%), Gaps = 4/100 (4%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
V+T G GQLGH R +P V LD + ++ + G H+LAL K QVY+WG ++
Sbjct: 55 VYTCGCNDLGQLGHEK--SRKKPEQVVALDAQNIVAVSCGEAHTLALNDKGQVYAWGLDS 112
Query: 588 FGQLG--HSDFPTTVPRLAKISSENGVWSIAAGRDYSLFL 625
GQLG S+ VPR K S+ + +A G +SL L
Sbjct: 113 DGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLAL 152
Score = 40.4 bits (93), Expect = 0.014
Identities = 25/66 (37%), Positives = 33/66 (50%), Gaps = 1/66 (1%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKS-QVYSWGSN 586
V+T+G G GQLGH + P V L G V + G H+ A S ++YS+G
Sbjct: 263 VFTFGAGGYGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLG 322
Query: 587 TFGQLG 592
GQLG
Sbjct: 323 GNGQLG 328
Score = 39.3 bits (90), Expect = 0.032
Identities = 27/99 (27%), Positives = 45/99 (45%), Gaps = 3/99 (3%)
Query: 531 WGKGKEGQLGHGDVLPR--LQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTF 588
WG GQLG G + L+P K V + G H++ + VY+ G N
Sbjct: 4 WGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDL 63
Query: 589 GQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVD 627
GQLGH ++ + ++N + +++ G ++L L D
Sbjct: 64 GQLGHEKSRKKPEQVVALDAQN-IVAVSCGEAHTLALND 101
>gi|126032348 hect domain and RLD 2 [Homo sapiens]
Length = 4834
Score = 88.6 bits (218), Expect = 5e-17
Identities = 54/155 (34%), Positives = 81/155 (52%), Gaps = 4/155 (2%)
Query: 477 GGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKE 536
G RL + G S +P LL V + V + SG L S EV++WG+ ++
Sbjct: 4012 GAGGRLGIGGTESVSTPTLLESIQHVFIKKVAVN---SGGKHCLALSSEGEVYSWGEAED 4068
Query: 537 GQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF 596
G+LGHG+ P +P ++ L G EV+ + AGG HS +TA +Y+WG +G+LGHSD
Sbjct: 4069 GKLGHGNRSPCDRPRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDS 4128
Query: 597 PTTV-PRLAKISSENGVWSIAAGRDYSLFLVDTED 630
+ P+L + + V IA G + L T+D
Sbjct: 4129 EDQLKPKLVEALQGHRVVDIACGSGDAQTLCLTDD 4163
Score = 78.2 bits (191), Expect = 6e-14
Identities = 56/181 (30%), Positives = 85/181 (46%), Gaps = 12/181 (6%)
Query: 41 KTVLQAALGVKHGVLLTEDGEVYSFGTLPW-RSGPVEICPS-SPILENALVGQYVITVAT 98
K + A G H LT GE+Y++G + R G + P + L+G VI VA
Sbjct: 3099 KRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVKVLLGHRVIQVAC 3158
Query: 99 GSFHSG--AVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLA 156
GS + A+TD G+ + WG+ G+ + P + + + + Q+
Sbjct: 3159 GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-------VCQIE 3211
Query: 157 CGEEHTLALSISREIWAWGTGCQLGL-ITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLA 215
CG + +LAL+ S +W WG G L + V KPQ VE L G+ ++ VA GA H LA
Sbjct: 3212 CGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLA 3271
Query: 216 L 216
+
Sbjct: 3272 V 3272
Score = 77.0 bits (188), Expect = 1e-13
Identities = 57/198 (28%), Positives = 93/198 (46%), Gaps = 12/198 (6%)
Query: 491 VSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQP 550
++P+L++ A +R +V +S L + EV++WG G G+LGHGD +P +P
Sbjct: 482 LAPQLVQGLA---SRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGHGDTVPLEEP 538
Query: 551 LCVKCLDGKE----VIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGH-SDFPTTVPRLAK 605
+ GK+ V+H+ G +S A+TA+ ++Y+WG +G+LGH S +P L
Sbjct: 539 KVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSEDEAIPMLVA 598
Query: 606 ISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCS 665
V +A G + L TE+ Q + G G G KTP L+
Sbjct: 599 GLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDG----DYGKLGRGGSDGCKTPKLIEKL 654
Query: 666 KLGYISRVTAGKDSYLAL 683
+ + +V G +AL
Sbjct: 655 QDLDVVKVRCGSQFSIAL 672
Score = 75.1 bits (183), Expect = 5e-13
Identities = 54/186 (29%), Positives = 96/186 (51%), Gaps = 14/186 (7%)
Query: 476 EGGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGK 535
E + RL L G+ S P + R+ + + V +SG A ++ +V++WG+G
Sbjct: 3018 EATNGRLGL-GISSGTVP-IPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGEGD 3075
Query: 536 EGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD 595
+G+LGH + +P ++ L K + + G HS ALT+ ++Y+WG +G+LGH D
Sbjct: 3076 DGKLGHFSRMNCDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGD 3135
Query: 596 FPTTV-PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYS------GR--QDPTEG 646
T + P++ K+ + V +A G + L T++ GL +S G+ + +EG
Sbjct: 3136 NTTQLKPKMVKVLLGHRVIQVACGSRDAQTLALTDE---GLVFSWGDGDFGKLGRGGSEG 3192
Query: 647 DNLPEN 652
N+P+N
Sbjct: 3193 CNIPQN 3198
Score = 75.1 bits (183), Expect = 5e-13
Identities = 63/204 (30%), Positives = 97/204 (47%), Gaps = 21/204 (10%)
Query: 25 AGSFPITPERLPGWGGKTVLQAAL--GVKHGVLLTEDGEVYSFGTLPWRSGPV----EIC 78
+G+ PI P ++ V + A+ G +H LT DG+V+S+G G + +
Sbjct: 3030 SGTVPI-PRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWGE--GDDGKLGHFSRMN 3086
Query: 79 PSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
P L AL + + +A GS HS A+T +G Y WG G+ + +P V
Sbjct: 3087 CDKPRLIEALKTKRIRDIACGSSHSAALTSSGELYTWGLGEYGRLGHGDNTTQLKPKMVK 3146
Query: 139 IADSEASPLLAVRILQLACG--EEHTLALSISREIWAWGTGCQLGLITTAFP--VTKPQK 194
+ LL R++Q+ACG + TLAL+ +++WG G G + PQ
Sbjct: 3147 V-------LLGHRVIQVACGSRDAQTLALTDEGLVFSWGDG-DFGKLGRGGSEGCNIPQN 3198
Query: 195 VEHLAGRVVLQVACGAFHSLALVQ 218
+E L G+ V Q+ CGA SLAL +
Sbjct: 3199 IERLNGQGVCQIECGAQFSLALTK 3222
Score = 73.2 bits (178), Expect = 2e-12
Identities = 40/112 (35%), Positives = 59/112 (52%), Gaps = 5/112 (4%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
VWTWGKG +LGHG + +P V+ L GK+++H+ G H LA+T QVY+WG N
Sbjct: 3226 VWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDND 3285
Query: 588 FGQLGHSDFPTTV---PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLY 636
GQ G+ TTV P L + + +A G +S+ + P ++
Sbjct: 3286 HGQQGNG--TTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVATPSVH 3335
Score = 70.9 bits (172), Expect = 1e-11
Identities = 55/176 (31%), Positives = 83/176 (47%), Gaps = 14/176 (7%)
Query: 49 GVKHGVLLTEDGEVYSFGTLP---WRSGPVEICPSSPILENALVGQYVITVATGSFHSGA 105
G KH + L+ +GEVYS+G G C ++E+ L G V+ VA G HS
Sbjct: 4047 GGKHCLALSSEGEVYSWGEAEDGKLGHGNRSPCDRPRVIES-LRGIEVVDVAAGGAHSAC 4105
Query: 106 VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC--GEEHTL 163
VT G Y WG+ G+ ++ + +P V L R++ +AC G+ TL
Sbjct: 4106 VTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLV-------EALQGHRVVDIACGSGDAQTL 4158
Query: 164 ALSISREIWAWGTGCQLGLITTAFPVTK-PQKVEHLAGRVVLQVACGAFHSLALVQ 218
L+ +W+WG G L K P K++ L G V++V CG+ S+AL +
Sbjct: 4159 CLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLGVVKVECGSQFSVALTK 4214
Score = 69.3 bits (168), Expect = 3e-11
Identities = 54/177 (30%), Positives = 86/177 (48%), Gaps = 19/177 (10%)
Query: 43 VLQAALGVKHGVLLTEDGEVYSFGT-------LPWRSGPVEICPSSPILENALVGQYVIT 95
V+Q A G K +T +G+VY+ G L SG V I L + +V + +
Sbjct: 2994 VVQVAGGSKSLFAVTVEGKVYACGEATNGRLGLGISSGTVPIPRQITALSSYVVKK--VA 3051
Query: 96 VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQL 155
V +G H+ A+T +G + WGE G+ ++ +P + ++ RI +
Sbjct: 3052 VHSGGRHATALTVDGKVFSWGEGDDGKLGHFSRMNCDKPRLIEALKTK-------RIRDI 3104
Query: 156 ACGEEHTLALSISREIWAWGTGCQLGLITTAFPVT--KPQKVEHLAGRVVLQVACGA 210
ACG H+ AL+ S E++ WG G + G + T KP+ V+ L G V+QVACG+
Sbjct: 3105 ACGSSHSAALTSSGELYTWGLG-EYGRLGHGDNTTQLKPKMVKVLLGHRVIQVACGS 3160
Score = 67.8 bits (164), Expect = 8e-11
Identities = 58/212 (27%), Positives = 102/212 (48%), Gaps = 18/212 (8%)
Query: 18 GLVHIWQAGSFPITPERLPGWGGKTVLQAALGVK--HGVLLTEDGEVYSFGTLPW-RSGP 74
G V+ S + P+ + G + +++ A H + L GEVYS+G R G
Sbjct: 470 GRVYTQAYNSDTLAPQLVQGLASRNIVKIAAHSDGHHYLALAATGEVYSWGCGDGGRLGH 529
Query: 75 VEICP-SSPILENAL----VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQ 129
+ P P + +A G++V+ +A GS +S A+T G Y WG + G+ + +
Sbjct: 530 GDTVPLEEPKVISAFSGKQAGKHVVHIACGSTYSAAITAEGELYTWGRGNYGRLGHGSSE 589
Query: 130 YVPEPNPVSIADSEASPLLAVRILQLAC--GEEHTLALSISREIWAWGTGCQLGLITTAF 187
E P+ +A L ++++ +AC G+ TLA++ + ++W+WG G L
Sbjct: 590 --DEAIPMLVAG-----LKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGS 642
Query: 188 PVTK-PQKVEHLAGRVVLQVACGAFHSLALVQ 218
K P+ +E L V++V CG+ S+AL +
Sbjct: 643 DGCKTPKLIEKLQDLDVVKVRCGSQFSIALTK 674
Score = 65.9 bits (159), Expect = 3e-10
Identities = 57/183 (31%), Positives = 90/183 (49%), Gaps = 16/183 (8%)
Query: 40 GKTVLQAALGVKHG--VLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVI 94
G V+Q A G + + LT++G V+S+G + G E C +E L GQ V
Sbjct: 3150 GHRVIQVACGSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIER-LNGQGVC 3208
Query: 95 TVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQ 154
+ G+ S A+T +GV + WG+ + + +V +P V L +I+
Sbjct: 3209 QIECGAQFSLALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVE-------GLRGKKIVH 3261
Query: 155 LACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFH 212
+A G H LA++ S +++AWG Q G TT KP V+ L G+ + +VACG+ H
Sbjct: 3262 VAVGALHCLAVTDSGQVYAWGDNDHGQQGNGTTTVN-RKPTLVQGLEGQKITRVACGSSH 3320
Query: 213 SLA 215
S+A
Sbjct: 3321 SVA 3323
Score = 65.5 bits (158), Expect = 4e-10
Identities = 44/132 (33%), Positives = 64/132 (48%), Gaps = 3/132 (2%)
Query: 500 ARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGK 559
A +K V+ SG+A L + +VW+WG G G+LG G P ++ L
Sbjct: 598 AGLKGLKVIDVACGSGDAQTLAVTENGQVWSWGDGDYGKLGRGGSDGCKTPKLIEKLQDL 657
Query: 560 EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGH-SDFPTTVPRLAKISSENGVWSIAAG 618
+V+ + G S+ALT QVYSWG +LGH ++ P+L + V +AAG
Sbjct: 658 DVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAG 717
Query: 619 RDYSLFLVDTED 630
+ L L TED
Sbjct: 718 STHCLAL--TED 727
Score = 65.5 bits (158), Expect = 4e-10
Identities = 71/244 (29%), Positives = 106/244 (43%), Gaps = 14/244 (5%)
Query: 443 PEGLKDSREEQVKQESMQGKKSSSLVDIREEETEGGSR--RLSLPGLLSQVSPRLLRKAA 500
P ++ R +V + G S+ + + T G R RL Q+ P+L+
Sbjct: 4082 PRVIESLRGIEVVDVAAGGAHSACVTAAGDLYTWGKGRYGRLGHSDSEDQLKPKLVEA-- 4139
Query: 501 RVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKE 560
++ VV SG+A L + VW+WG G G+LG G P+ + L G
Sbjct: 4140 -LQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGCKVPMKIDSLTGLG 4198
Query: 561 VIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGH-SDFPTTVPRLAKISSENGVWSIAAGR 619
V+ +E G S+ALT VY+WG + +LGH SD PR + V +IA G
Sbjct: 4199 VVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQGLQGKKVIAIATG- 4257
Query: 620 DYSLFLV-DTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKD 678
SL V TED + +Y G D EG + + P L++ + ++RV G
Sbjct: 4258 --SLHCVCCTEDGE--VYTWGDND--EGQLGDGTTNAIQRPRLVAALQGKKVNRVACGSA 4311
Query: 679 SYLA 682
LA
Sbjct: 4312 HTLA 4315
Score = 63.5 bits (153), Expect = 2e-09
Identities = 60/221 (27%), Positives = 98/221 (44%), Gaps = 19/221 (8%)
Query: 30 ITPERLPGWGGKTVLQAALGVKHG--VLLTEDGEVYSFGTLPWRS---GPVEICPSSPIL 84
+ P+ + G V+ A G + LT+D V+S+G + G + C P+
Sbjct: 4132 LKPKLVEALQGHRVVDIACGSGDAQTLCLTDDDTVWSWGDGDYGKLGRGGSDGC-KVPMK 4190
Query: 85 ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEA 144
++L G V+ V GS S A+T +G Y WG+ + + +V P V
Sbjct: 4191 IDSLTGLGVVKVECGSQFSVALTKSGAVYTWGKGDYHRLGHGSDDHVRRPRQVQ------ 4244
Query: 145 SPLLAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRV 202
L +++ +A G H + + E++ WG QLG TT + +P+ V L G+
Sbjct: 4245 -GLQGKKVIAIATGSLHCVCCTEDGEVYTWGDNDEGQLGDGTTN-AIQRPRLVAALQGKK 4302
Query: 203 VLQVACGAFHSLALVQCLPSQDLK---PVPERCNQCSQLLI 240
V +VACG+ H+LA P+ K VP N ++ I
Sbjct: 4303 VNRVACGSAHTLAWSTSKPASAGKLPAQVPMEYNHLQEIPI 4343
Score = 60.1 bits (144), Expect = 2e-08
Identities = 29/60 (48%), Positives = 39/60 (65%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
+V++WGKG +LGHG P ++ L GK+VI + AG H LALT S+V+SWGSN
Sbjct: 677 QVYSWGKGDNQRLGHGTEEHVRYPKLLEGLQGKKVIDVAAGSTHCLALTEDSEVHSWGSN 736
Score = 59.7 bits (143), Expect = 2e-08
Identities = 48/164 (29%), Positives = 73/164 (44%), Gaps = 25/164 (15%)
Query: 16 ERGLVHIWQAGSF-------------PITPERLPGWGGKTVLQAALGVKHGVLLTEDGEV 62
+ GLV W G F P ERL G G V Q G + + LT+ G V
Sbjct: 3170 DEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG---VCQIECGAQFSLALTKSGVV 3226
Query: 63 YSFGTLPW-RSGP-VEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSA 120
+++G + R G ++ P + L G+ ++ VA G+ H AVTD+G Y WG+N
Sbjct: 3227 WTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQVYAWGDNDH 3286
Query: 121 GQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLA 164
GQ +P V + + +I ++ACG H++A
Sbjct: 3287 GQQGNGTTTVNRKPTLVQGLEGQ-------KITRVACGSSHSVA 3323
Score = 55.8 bits (133), Expect = 3e-07
Identities = 51/186 (27%), Positives = 84/186 (45%), Gaps = 11/186 (5%)
Query: 515 GEADALLPSLRTE--VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSL 572
G DA +L E V++WG G G+LG G P ++ L+G+ V +E G SL
Sbjct: 3159 GSRDAQTLALTDEGLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFSL 3218
Query: 573 ALTAKSQVYSWGSNTFGQLGH-SDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDF 631
ALT V++WG + +LGH SD P++ + + +A G + L + D+
Sbjct: 3219 ALTKSGVVWTWGKGDYFRLGHGSDVHVRKPQVVEGLRGKKIVHVAVGALHCLAVTDSGQ- 3277
Query: 632 QPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDKNIMGY 691
+Y G D + N + ++ P L+ + I+RV G +A ++
Sbjct: 3278 ---VYAWGDNDHGQQGN--GTTTVNRKPTLVQGLEGQKITRVACGSSHSVAWTTVDVA-- 3330
Query: 692 IASLHE 697
S+HE
Sbjct: 3331 TPSVHE 3336
Score = 54.7 bits (130), Expect = 7e-07
Identities = 47/165 (28%), Positives = 73/165 (44%), Gaps = 12/165 (7%)
Query: 31 TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLP-WRSGP-VEICPSSPILENAL 88
TP+ + V++ G + + LT+DG+VYS+G R G E P L L
Sbjct: 647 TPKLIEKLQDLDVVKVRCGSQFSIALTKDGQVYSWGKGDNQRLGHGTEEHVRYPKLLEGL 706
Query: 89 VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148
G+ VI VA GS H A+T++ + WG N QC + V +P P ++ +
Sbjct: 707 QGKKVIDVAAGSTHCLALTEDSEVHSWGSND--QCQHFDTLRVTKPEPAALPGLDTK--- 761
Query: 149 AVRILQLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQ 193
I+ +ACG + A S E W G ++ + +T Q
Sbjct: 762 --HIVGIACGPAQSFAWSSCSE---WSIGLRVPFVVDICSMTFEQ 801
Score = 40.0 bits (92), Expect = 0.019
Identities = 49/186 (26%), Positives = 73/186 (39%), Gaps = 33/186 (17%)
Query: 523 SLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYS 582
++RT+V+ WG + QLG P + L V+ + G A+T + +VY+
Sbjct: 2956 TIRTKVFVWGLNDKDQLGGLKGSKIKVPSFSETLSALNVVQVAGGSKSLFAVTVEGKVYA 3015
Query: 583 WGSNTFGQLGHSDFPTTVPRLAKISSENG-----VWSIAAGRDYSLFLVDTEDFQPGLYY 637
G T G+LG TVP +I++ + V + GR + VD + F G
Sbjct: 3016 CGEATNGRLGLGISSGTVPIPRQITALSSYVVKKVAVHSGGRHATALTVDGKVFSWG--- 3072
Query: 638 SGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYL-ALVDKNIMGY-IASL 695
EGD+ KLG+ SR+ K + AL K I S
Sbjct: 3073 -------EGDD----------------GKLGHFSRMNCDKPRLIEALKTKRIRDIACGSS 3109
Query: 696 HELATT 701
H A T
Sbjct: 3110 HSAALT 3115
Score = 37.0 bits (84), Expect = 0.16
Identities = 33/112 (29%), Positives = 50/112 (44%), Gaps = 12/112 (10%)
Query: 109 NGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSIS 168
+G Y WG N GQ V P P L +R +QL GE+ A++
Sbjct: 3951 SGTIYGWGHNHRGQLGGIEGAKVKVPTP-------CEALATLRPVQLIGGEQTLFAVTAD 4003
Query: 169 REIWA--WGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVA--CGAFHSLAL 216
+++A +G G +LG+ T V+ P +E + + +VA G H LAL
Sbjct: 4004 GKLYATGYGAGGRLGIGGTE-SVSTPTLLESIQHVFIKKVAVNSGGKHCLAL 4054
>gi|7657152 hect domain and RLD 3 [Homo sapiens]
Length = 1050
Score = 88.6 bits (218), Expect = 5e-17
Identities = 65/183 (35%), Positives = 86/183 (46%), Gaps = 18/183 (9%)
Query: 41 KTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGS 100
++V + A G H V L EDGEVY+ G E + P AL Q++I VA G
Sbjct: 34 RSVKEVACGGNHSVFLLEDGEVYTCGLNTKGQLGHEREGNKPEQIGALADQHIIHVACGE 93
Query: 101 FHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVR-----ILQL 155
HS A++D G + WG S GQ + ++ DS A P L + ILQ+
Sbjct: 94 SHSLALSDRGQLFSWGAGSDGQLGL-----------MTTEDSVAVPRLIQKLNQQTILQV 142
Query: 156 ACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
+CG H LAL+ + + WG QLGL PQ+V L G + QVA G HS
Sbjct: 143 SCGNWHCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHS 202
Query: 214 LAL 216
AL
Sbjct: 203 FAL 205
Score = 81.6 bits (200), Expect = 6e-15
Identities = 66/218 (30%), Positives = 106/218 (48%), Gaps = 24/218 (11%)
Query: 16 ERGLVHIWQAGS-----------FPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64
+RG + W AGS P + +T+LQ + G H + L DG+ ++
Sbjct: 101 DRGQLFSWGAGSDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQFFT 160
Query: 65 FG-TLPWRSGPVEICPS--SPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAG 121
+G + G + PS SP +L G + VA G HS A++ +G + WG N+AG
Sbjct: 161 WGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLSGAVFGWGMNNAG 220
Query: 122 QCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGC--Q 179
Q +++++ P V + L +++ ++CGEEHT L+ S ++ +G G Q
Sbjct: 221 QLGLSDEKDRESPCHVKL-------LRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQ 273
Query: 180 LGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
LG + V P++V L G V Q+ACG H+LA V
Sbjct: 274 LGHDSMNDEV-NPRRVLELMGSEVTQIACGRQHTLAFV 310
Score = 70.5 bits (171), Expect = 1e-11
Identities = 51/194 (26%), Positives = 95/194 (48%), Gaps = 16/194 (8%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSS-----PILEN 86
PE++ + ++ A G H + L++ G+++S+G G + + + P L
Sbjct: 75 PEQIGALADQHIIHVACGESHSLALSDRGQLFSWGA--GSDGQLGLMTTEDSVAVPRLIQ 132
Query: 87 ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
L Q ++ V+ G++H A+ +G + WG+NS GQ + +++ + +P + E P
Sbjct: 133 KLNQQTILQVSCGNWHCLALAADGQFFTWGKNSHGQLGL-GKEFPSQASPQRVRSLEGIP 191
Query: 147 LLAVRILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVEHLAGRVVL 204
L Q+A G H+ ALS+S ++ WG QLGL + P V+ L + V+
Sbjct: 192 L-----AQVAAGGAHSFALSLSGAVFGWGMNNAGQLGL-SDEKDRESPCHVKLLRTQKVV 245
Query: 205 QVACGAFHSLALVQ 218
++CG H+ L +
Sbjct: 246 YISCGEEHTAVLTK 259
Score = 65.9 bits (159), Expect = 3e-10
Identities = 48/151 (31%), Positives = 70/151 (46%), Gaps = 10/151 (6%)
Query: 489 SQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRL 548
SQ SP+ +R + V +G A + SL V+ WG GQLG D R
Sbjct: 177 SQASPQRVRSLEGIPLAQVA-----AGGAHSFALSLSGAVFGWGMNNAGQLGLSDEKDRE 231
Query: 549 QPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV-PRLAKIS 607
P VK L ++V+++ G H+ LT V+++G+ + GQLGH V PR
Sbjct: 232 SPCHVKLLRTQKVVYISCGEEHTAVLTKSGGVFTFGAGSCGQLGHDSMNDEVNPRRVLEL 291
Query: 608 SENGVWSIAAGRDYSLFLVDTEDFQPGLYYS 638
+ V IA GR ++L V + GL Y+
Sbjct: 292 MGSEVTQIACGRQHTLAFVPSS----GLIYA 318
Score = 60.1 bits (144), Expect = 2e-08
Identities = 38/118 (32%), Positives = 64/118 (54%), Gaps = 11/118 (9%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLG-----HGDVLPRLQPLCVKCLDGKEVIHLEAGGY 569
GE+ +L S R ++++WG G +GQLG +PRL ++ L+ + ++ + G +
Sbjct: 92 GESHSLALSDRGQLFSWGAGSDGQLGLMTTEDSVAVPRL----IQKLNQQTILQVSCGNW 147
Query: 570 HSLALTAKSQVYSWGSNTFGQLG-HSDFPTTV-PRLAKISSENGVWSIAAGRDYSLFL 625
H LAL A Q ++WG N+ GQLG +FP+ P+ + + +AAG +S L
Sbjct: 148 HCLALAADGQFFTWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFAL 205
Score = 57.0 bits (136), Expect = 1e-07
Identities = 35/107 (32%), Positives = 57/107 (53%), Gaps = 4/107 (3%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
EV+T G +GQLGH +P + L + +IH+ G HSLAL+ + Q++SWG+
Sbjct: 54 EVYTCGLNTKGQLGHER--EGNKPEQIGALADQHIIHVACGESHSLALSDRGQLFSWGAG 111
Query: 587 TFGQLG--HSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDF 631
+ GQLG ++ VPRL + ++ + ++ G + L L F
Sbjct: 112 SDGQLGLMTTEDSVAVPRLIQKLNQQTILQVSCGNWHCLALAADGQF 158
Score = 43.1 bits (100), Expect = 0.002
Identities = 29/99 (29%), Positives = 46/99 (46%), Gaps = 3/99 (3%)
Query: 531 WGKGKEGQLGHGDVLPRL--QPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTF 588
WG GQ G L + +P + + V + GG HS+ L +VY+ G NT
Sbjct: 4 WGYWSLGQPGISTNLQGIVAEPQVCGFISDRSVKEVACGGNHSVFLLEDGEVYTCGLNTK 63
Query: 589 GQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVD 627
GQLGH ++ ++ ++ + +A G +SL L D
Sbjct: 64 GQLGHEREGNKPEQIGALADQH-IIHVACGESHSLALSD 101
>gi|61563742 hect domain and RLD 6 [Homo sapiens]
Length = 1022
Score = 85.5 bits (210), Expect = 4e-16
Identities = 68/203 (33%), Positives = 90/203 (44%), Gaps = 14/203 (6%)
Query: 23 WQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLP----WRSGPVEIC 78
W A S + R G G +LQAA G +H +LL + V S G R G
Sbjct: 5 WGADSRELQRRRTAGSPGAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGE 64
Query: 79 PSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
PI AL V V+ G HS AV G + WG S GQ + E +S
Sbjct: 65 LPEPI--QALETLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIG------EFKEIS 116
Query: 139 IADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVE 196
+ L ++I+Q++CG H+LALS ++++WG QLGL PQ+V
Sbjct: 117 FTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVR 176
Query: 197 HLAGRVVLQVACGAFHSLALVQC 219
L G + QVA G HS AL C
Sbjct: 177 SLEGIPLAQVAAGGAHSFALSLC 199
Score = 79.7 bits (195), Expect = 2e-14
Identities = 65/218 (29%), Positives = 109/218 (50%), Gaps = 24/218 (11%)
Query: 17 RGLVHIWQAGS-----------FPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSF 65
+G V W AGS TP+++ ++Q + G H + L++D +V+S+
Sbjct: 93 KGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLALSKDSQVFSW 152
Query: 66 G-TLPWRSGPVEICPS--SPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQ 122
G + G + PS SP +L G + VA G HS A++ G ++ WG NSAGQ
Sbjct: 153 GKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHSFALSLCGTSFGWGSNSAGQ 212
Query: 123 CAVANQQYVPEPN-PVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWG--TGCQ 179
A++ + + N P+S+ L + ++ ++CG+ HT L+ +++ +G Q
Sbjct: 213 LALSGRNVPVQSNKPLSV-----GALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQ 267
Query: 180 LGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
LG T PQ VE + G +V Q+ CG++H+LA V
Sbjct: 268 LGYSPTP-EKRGPQLVERIDG-LVSQIDCGSYHTLAYV 303
Score = 67.0 bits (162), Expect = 1e-10
Identities = 42/123 (34%), Positives = 65/123 (52%), Gaps = 3/123 (2%)
Query: 506 TVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLP-RLQPLCVKCLDGKEVIHL 564
T+++ G+ +L + V+ WG G EGQLG G+ P + L+ ++I +
Sbjct: 74 TLIVDLVSCGKEHSLAVCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQV 133
Query: 565 EAGGYHSLALTAKSQVYSWGSNTFGQLG-HSDFPTTV-PRLAKISSENGVWSIAAGRDYS 622
G YHSLAL+ SQV+SWG N+ GQLG +FP+ P+ + + +AAG +S
Sbjct: 134 SCGHYHSLALSKDSQVFSWGKNSHGQLGLGKEFPSQASPQRVRSLEGIPLAQVAAGGAHS 193
Query: 623 LFL 625
L
Sbjct: 194 FAL 196
Score = 60.5 bits (145), Expect = 1e-08
Identities = 40/130 (30%), Positives = 64/130 (49%), Gaps = 10/130 (7%)
Query: 93 VITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRI 152
+I V+ G +HS A++ + + WG+NS GQ + +++ + +P + E PL
Sbjct: 130 IIQVSCGHYHSLALSKDSQVFSWGKNSHGQLGLG-KEFPSQASPQRVRSLEGIPLA---- 184
Query: 153 LQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPV--TKPQKVEHLAGRVVLQVAC 208
Q+A G H+ ALS+ + WG+ QL L PV KP V L V+ ++C
Sbjct: 185 -QVAAGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPVQSNKPLSVGALKNLGVVYISC 243
Query: 209 GAFHSLALVQ 218
G H+ L Q
Sbjct: 244 GDAHTAVLTQ 253
Score = 49.7 bits (117), Expect = 2e-05
Identities = 34/112 (30%), Positives = 51/112 (45%), Gaps = 8/112 (7%)
Query: 489 SQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQL---GHGDVL 545
SQ SP+ +R + V +G A + SL + WG GQL G +
Sbjct: 168 SQASPQRVRSLEGIPLAQVA-----AGGAHSFALSLCGTSFGWGSNSAGQLALSGRNVPV 222
Query: 546 PRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFP 597
+PL V L V+++ G H+ LT +V+++G N GQLG+S P
Sbjct: 223 QSNKPLSVGALKNLGVVYISCGDAHTAVLTQDGKVFTFGDNRSGQLGYSPTP 274
Score = 47.0 bits (110), Expect = 2e-04
Identities = 33/114 (28%), Positives = 54/114 (47%), Gaps = 2/114 (1%)
Query: 514 SGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLA 573
SGE +LL V + G GQLG P ++ L+ V + G HSLA
Sbjct: 30 SGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLIVDLVSCGKEHSLA 89
Query: 574 LTAKSQVYSWGSNTFGQLGHSDFP--TTVPRLAKISSENGVWSIAAGRDYSLFL 625
+ K +V++WG+ + GQLG +F + P+ ++ + ++ G +SL L
Sbjct: 90 VCHKGRVFAWGAGSEGQLGIGEFKEISFTPKKIMTLNDIKIIQVSCGHYHSLAL 143
Score = 37.7 bits (86), Expect = 0.093
Identities = 28/97 (28%), Positives = 47/97 (48%), Gaps = 10/97 (10%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLA- 573
G+A + + +V+T+G + GQLG+ + P V+ +DG V ++ G YH+LA
Sbjct: 244 GDAHTAVLTQDGKVFTFGDNRSGQLGYSPTPEKRGPQLVERIDGL-VSQIDCGSYHTLAY 302
Query: 574 LTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSEN 610
+ QV S+ GH T+ P + +EN
Sbjct: 303 VHTTGQVVSF--------GHGPSDTSKPTHPEALTEN 331
Score = 31.2 bits (69), Expect = 8.7
Identities = 21/71 (29%), Positives = 34/71 (47%), Gaps = 9/71 (12%)
Query: 558 GKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLG-----HSDFPTTVPRLAKISSENGV 612
G E++ +G HSL L +V S G N+ GQLG + P + L + V
Sbjct: 22 GAELLQAASGERHSLLLLTNHRVLSCGDNSRGQLGRRGAQRGELPEPIQALETLI----V 77
Query: 613 WSIAAGRDYSL 623
++ G+++SL
Sbjct: 78 DLVSCGKEHSL 88
>gi|18254456 testis-specific gene A2 [Homo sapiens]
Length = 309
Score = 83.2 bits (204), Expect = 2e-15
Identities = 49/175 (28%), Positives = 80/175 (45%), Gaps = 11/175 (6%)
Query: 1051 GRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMC 1110
GR +G+ HGRG + P+G Y G + G G G Y+ N A Y+G + K
Sbjct: 23 GRNEAGERHGRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGA-----RYIGEYVRNKKH 77
Query: 1111 GQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDIT 1170
GQG + Y G +EG + +++RHGHG+ + + G+W ++ G G +
Sbjct: 78 GQGTFIYPDGSRYEGEWANDLRHGHGV-----YYYINNDTYTGEWFAHQRHGQGTYLYAE 132
Query: 1171 RGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEF 1225
G KY+G W + +G ++ Y+G F +G G + + GE+
Sbjct: 133 TGSKYVGTWVNGQQEGTAELI-HLNHRYQGKFLNKNPVGPGKYVFDVGCEQHGEY 186
Score = 69.3 bits (168), Expect = 3e-11
Identities = 44/160 (27%), Positives = 71/160 (44%), Gaps = 11/160 (6%)
Query: 1048 TYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEG 1107
TY+G + GK HG+G+ K+ +G Y G + + G G + P+ + Y G W
Sbjct: 43 TYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGS-----RYEGEWAND 97
Query: 1108 KMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFD 1167
G GVY Y + + + G + + RHG G L + + S ++G WV ++ G +
Sbjct: 98 LRHGHGVYYYINNDTYTGEWFAHQRHGQGTY----LYAETGSKYVGTWVNGQQE--GTAE 151
Query: 1168 DITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKM 1207
I +Y G + + G G V G G + L M
Sbjct: 152 LIHLNHRYQGKFLNKNPVGPGKYVFDVGCEQHGEYRLTDM 191
Score = 60.1 bits (144), Expect = 2e-08
Identities = 43/138 (31%), Positives = 64/138 (46%), Gaps = 16/138 (11%)
Query: 1047 ATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKE 1106
A Y G ++ K HG+G +PDG Y G + N L G+G Y N D Y G W
Sbjct: 65 ARYIGEYVRNKKHGQGTFIYPDGSRYEGEWANDLRHGHGVYYYIN-----NDTYTGEWFA 119
Query: 1107 GKMCGQGVYSYA-SGEVFEGCFQDNMRHGHGLL------RSGKLTSSSPSMFIGQWVMD- 1158
+ GQG Y YA +G + G + + + G L GK + +P + G++V D
Sbjct: 120 HQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIHLNHRYQGKFLNKNP-VGPGKYVFDV 178
Query: 1159 --KKAGYGVFDDITRGEK 1174
++ G D+ RGE+
Sbjct: 179 GCEQHGEYRLTDMERGEE 196
Score = 57.8 bits (138), Expect = 9e-08
Identities = 44/158 (27%), Positives = 68/158 (43%), Gaps = 13/158 (8%)
Query: 1069 GKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVYSYASGEVFEGCFQ 1128
G+ G G G G R+PN D Y G ++ GK GQG+Y + +G + G +
Sbjct: 18 GEYEGGRNEAGERHGRGRARLPNG-----DTYEGSYEFGKRHGQGIYKFKNGARYIGEYV 72
Query: 1129 DNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNG 1188
N +HG G S + G+W D + G+GV+ I + Y G W G G
Sbjct: 73 RNKKHG-----QGTFIYPDGSRYEGEWANDLRHGHGVYYYI-NNDTYTGEWFAHQRHGQG 126
Query: 1189 V-VVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEF 1225
+ + G Y G + + G L+ + Y+G+F
Sbjct: 127 TYLYAETGSKYVGTWVNGQQEGTAELIHLNHR-YQGKF 163
Score = 41.2 bits (95), Expect = 0.008
Identities = 25/85 (29%), Positives = 39/85 (45%), Gaps = 5/85 (5%)
Query: 1169 ITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDD 1228
+ G+ Y G ++ G G+ + G Y G + NK G G + D + YEGE+++D
Sbjct: 38 LPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRNKKHGQGTFIYPDGSRYEGEWAND 97
Query: 1229 WTLSGKGTLTMPNGDYIEGYFSGEW 1253
G G N D ++GEW
Sbjct: 98 -LRHGHGVYYYINND----TYTGEW 117
Score = 34.3 bits (77), Expect = 1.0
Identities = 18/59 (30%), Positives = 30/59 (50%), Gaps = 6/59 (10%)
Query: 1044 LKDATYDGRWLSGKPHGRGVLKWPD-GKMYSGMFRNGLEDGYGE-----YRIPNKAMNK 1096
+ + TY G W + + HG+G + + G Y G + NG ++G E +R K +NK
Sbjct: 108 INNDTYTGEWFAHQRHGQGTYLYAETGSKYVGTWVNGQQEGTAELIHLNHRYQGKFLNK 166
Score = 33.5 bits (75), Expect = 1.8
Identities = 21/73 (28%), Positives = 33/73 (45%), Gaps = 5/73 (6%)
Query: 1186 GNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYI 1245
G G G YEG++ K G G+ ++ Y GE+ + G+GT P+G
Sbjct: 32 GRGRARLPNGDTYEGSYEFGKRHGQGIYKFKNGARYIGEYVRN-KKHGQGTFIYPDGSRY 90
Query: 1246 EGYFSGEWGSGIK 1258
E GEW + ++
Sbjct: 91 E----GEWANDLR 99
>gi|57242759 regulator of chromosome condensation (RCC1) and BTB
(POZ) domain containing protein 1 [Homo sapiens]
Length = 531
Score = 82.4 bits (202), Expect = 3e-15
Identities = 64/200 (32%), Positives = 97/200 (48%), Gaps = 27/200 (13%)
Query: 30 ITPERLPGWGGKTVLQAALGV-KHGVLLTEDGEVYSFG----------TLPWRSGPVEIC 78
+ P++L G GK + + G H +L TEDG VY++G T PV++C
Sbjct: 63 LVPKKLEGLCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVC 122
Query: 79 PSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS 138
N L+ Q V+ VA GS HS A+ +G + WG N+ GQ + P P V+
Sbjct: 123 T------NLLIKQ-VVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVT 175
Query: 139 IADSEASPLLAVRILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVE 196
+ L R++ +ACG+ ++A+ + E++ WG QLGL +T P +V
Sbjct: 176 ------NCLHIKRVVGIACGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLT-PVRVA 228
Query: 197 HLAGRVVLQVACGAFHSLAL 216
L V Q+ CG H+LAL
Sbjct: 229 ALHSVCVNQIVCGYAHTLAL 248
Score = 62.0 bits (149), Expect = 5e-09
Identities = 50/183 (27%), Positives = 84/183 (45%), Gaps = 13/183 (7%)
Query: 512 TYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPL--CVKCLDGKEVIHLEAGGY 569
+Y LL + V+ WG QLG+G + P+ C L K+V+ + G +
Sbjct: 80 SYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAPVQVCTNLLI-KQVVEVACGSH 138
Query: 570 HSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKISS---ENGVWSIAAGRDYSLFLV 626
HS+AL A +V++WG N GQ+G S P K+++ V IA G+ S+ ++
Sbjct: 139 HSMALAADGEVFAWGYNNCGQVG-SGSTANQPTPRKVTNCLHIKRVVGIACGQTSSMAVL 197
Query: 627 DTEDFQPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGYISRVTAGKDSYLALVDK 686
D + G Y+G G N+ TPV ++ ++++ G LAL D+
Sbjct: 198 DNGEVY-GWGYNGNGQLGLG-----NNGNQLTPVRVAALHSVCVNQIVCGYAHTLALTDE 251
Query: 687 NIM 689
++
Sbjct: 252 GLL 254
Score = 57.4 bits (137), Expect = 1e-07
Identities = 36/104 (34%), Positives = 55/104 (52%), Gaps = 4/104 (3%)
Query: 489 SQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRL 548
+Q +PR + +K R V + G+ ++ EV+ WG GQLG G+ +L
Sbjct: 167 NQPTPRKVTNCLHIK-RVVGIA---CGQTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQL 222
Query: 549 QPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLG 592
P+ V L V + G H+LALT + +Y+WG+NT+GQLG
Sbjct: 223 TPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLG 266
Score = 55.8 bits (133), Expect = 3e-07
Identities = 42/135 (31%), Positives = 70/135 (51%), Gaps = 13/135 (9%)
Query: 88 LVGQYVITVATGSF-HSGAVTDNGVAYMWGENSAGQCA--VANQQYVPEPNPVSIADSEA 144
L G+ + +++ GS H T++GV Y WG N Q NQ P V + +
Sbjct: 71 LCGKKIKSLSYGSGPHVLLSTEDGVVYAWGHNGYSQLGNGTTNQGIAP----VQVCTN-- 124
Query: 145 SPLLAVRILQLACGEEHTLALSISREIWAWG-TGC-QLGLITTAFPVTKPQKVEHLAGRV 202
LL +++++ACG H++AL+ E++AWG C Q+G +TA T + L +
Sbjct: 125 --LLIKQVVEVACGSHHSMALAADGEVFAWGYNNCGQVGSGSTANQPTPRKVTNCLHIKR 182
Query: 203 VLQVACGAFHSLALV 217
V+ +ACG S+A++
Sbjct: 183 VVGIACGQTSSMAVL 197
Score = 45.4 bits (106), Expect = 4e-04
Identities = 36/141 (25%), Positives = 63/141 (44%), Gaps = 16/141 (11%)
Query: 41 KTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS----SPILENALVGQYVITV 96
K V+ A G + + ++GEVY +G +G + + + +P+ AL V +
Sbjct: 181 KRVVGIACGQTSSMAVLDNGEVYGWGYNG--NGQLGLGNNGNQLTPVRVAALHSVCVNQI 238
Query: 97 ATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQL- 155
G H+ A+TD G+ Y WG N+ GQ N+ + P + + R++++
Sbjct: 239 VCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMVEKE--------RVVEIA 290
Query: 156 ACGEEHTLALSI-SREIWAWG 175
AC HT A ++ WG
Sbjct: 291 ACHSAHTSAAKTQGGHVYMWG 311
Score = 36.6 bits (83), Expect = 0.21
Identities = 38/150 (25%), Positives = 65/150 (43%), Gaps = 17/150 (11%)
Query: 30 ITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVY-----SFGTLPWRSGPVEICPSSPIL 84
+TP R+ V Q G H + LT++G +Y ++G L + + P+ ++
Sbjct: 222 LTPVRVAALHSVCVNQIVCGYAHTLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHIMV 281
Query: 85 ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSE- 143
E V + I + S A T G YMWG+ GQ + +P S D
Sbjct: 282 EKERVVE--IAACHSAHTSAAKTQGGHVYMWGQ-CRGQSVI-----LPHLTHFSCTDDVF 333
Query: 144 ---ASPLLAVRILQLACGEEHTLALSISRE 170
A+P ++ R+L + + T+A S+ +E
Sbjct: 334 ACFATPAVSWRLLSVEHEDFLTVAESLKKE 363
Score = 33.1 bits (74), Expect = 2.3
Identities = 46/177 (25%), Positives = 75/177 (42%), Gaps = 21/177 (11%)
Query: 463 KSSSLVDIREEETEG----GSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEAD 518
++SS+ + E G G+ +L L +Q++P +R AA +V + G A
Sbjct: 190 QTSSMAVLDNGEVYGWGYNGNGQLGLGNNGNQLTP--VRVAA---LHSVCVNQIVCGYAH 244
Query: 519 ALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEA--GGYHSLALTA 576
L + ++ WG GQLG G+ L P + ++ + V+ + A + S A T
Sbjct: 245 TLALTDEGLLYAWGANTYGQLGTGNKNNLLSPAHI-MVEKERVVEIAACHSAHTSAAKTQ 303
Query: 577 KSQVYSWGSNTFGQLGHSDFPTTVPRLAKISSENGVWSIAA--GRDYSLFLVDTEDF 631
VY WG GQ +P L S + V++ A + L V+ EDF
Sbjct: 304 GGHVYMWG-QCRGQ------SVILPHLTHFSCTDDVFACFATPAVSWRLLSVEHEDF 353
>gi|13376267 MORN repeat containing 1 [Homo sapiens]
Length = 497
Score = 80.9 bits (198), Expect = 1e-14
Identities = 56/176 (31%), Positives = 76/176 (43%), Gaps = 28/176 (15%)
Query: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGK 1108
Y+G W +G+ HG G L + DG Y G F +G G G D + G + G+
Sbjct: 39 YEGEWKAGRKHGHGKLLFKDGSYYEGAFVDGEITGEGRRHWAWSG----DTFSGQFVLGE 94
Query: 1109 MCGQGVYSYASGEVFEGCFQDNMRHGHGLL--RSGKLTSSS--------PSMFI------ 1152
G GV Y +G +EG MR GHG L R G++ S P +
Sbjct: 95 PQGYGVMEYKAGGCYEGEVSHGMREGHGFLVDRDGQVYQGSFHDNKRHGPGQMLFQNGDK 154
Query: 1153 --GQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVV-----VTQFGLYYEGN 1201
G WV D++ G+GV G Y G W DV G G + VT +GL+ G+
Sbjct: 155 YDGDWVRDRRQGHGVL-RCADGSTYKGQWHSDVFSGLGSMAHCSGVTYYGLWINGH 209
Score = 72.0 bits (175), Expect = 4e-12
Identities = 57/209 (27%), Positives = 89/209 (42%), Gaps = 39/209 (18%)
Query: 1056 GKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGKMCGQGVY 1115
G P RG + P R +GYG Y PN Y G WK G+ G G
Sbjct: 7 GTPSSRGPRRDPP--------RRPPRNGYGVYVYPNSFFR----YEGEWKAGRKHGHGKL 54
Query: 1116 SYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFD-------- 1167
+ G +EG F D G G + + S F GQ+V+ + GYGV +
Sbjct: 55 LFKDGSYYEGAFVDGEITGEGR----RHWAWSGDTFSGQFVLGEPQGYGVMEYKAGGCYE 110
Query: 1168 -DITRGEK-------------YMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVL 1213
+++ G + Y G + D+ G G ++ Q G Y+G++ ++ G+GVL
Sbjct: 111 GEVSHGMREGHGFLVDRDGQVYQGSFHDNKRHGPGQMLFQNGDKYDGDWVRDRRQGHGVL 170
Query: 1214 LSEDDTIYEGEFSDDWTLSGKGTLTMPNG 1242
D + Y+G++ D SG G++ +G
Sbjct: 171 RCADGSTYKGQWHSD-VFSGLGSMAHCSG 198
>gi|126131099 guanine nucleotide exchange factor p532 [Homo sapiens]
Length = 4861
Score = 79.0 bits (193), Expect = 4e-14
Identities = 58/177 (32%), Positives = 82/177 (46%), Gaps = 15/177 (8%)
Query: 45 QAALGVKHGVLLTEDGE-VYSFG---TLPWRSGPVEICPSSPILENALVGQYVITVATGS 100
+ + G H + L++DG V+SFG G ++E AL G ++ V GS
Sbjct: 565 EVSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIE-ALQGMFIRKVCAGS 623
Query: 101 FHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEE 160
S A+T G Y WG G C P I + L A RI+ ++ G+
Sbjct: 624 QSSLALTSTGQVYAWG---CGACLGCGSSEATALRPKLIEE-----LAATRIVDVSIGDS 675
Query: 161 HTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLA 215
H LALS E++AWG Q G + P+TKP+KV L G + Q++ G HSLA
Sbjct: 676 HCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLDGIAIQQISAGTSHSLA 732
Score = 72.8 bits (177), Expect = 3e-12
Identities = 52/162 (32%), Positives = 83/162 (51%), Gaps = 15/162 (9%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKC-LDGKEVIHLEAGGYHSLALTAKSQVYSWGS 585
EV++WG G G+LGHG+ + P ++ L GK V+ + AG HS A+T ++Y+WG
Sbjct: 478 EVFSWGDGDYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAVTEDGELYTWGE 537
Query: 586 NTFGQLGHSDFPT-TVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPT 644
FG+LGH D + +P L K S G ++ G +++ L ++D + + G
Sbjct: 538 GDFGRLGHGDSNSRNIPTLVKDISNVG--EVSCGSSHTIAL--SKDGRTVWSFGG----- 588
Query: 645 EGDNLPENHSGSK---TPVLLSCSKLGYISRVTAGKDSYLAL 683
GDN H + P ++ + +I +V AG S LAL
Sbjct: 589 -GDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLAL 629
Score = 72.0 bits (175), Expect = 4e-12
Identities = 53/191 (27%), Positives = 96/191 (50%), Gaps = 15/191 (7%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSS----PILENA 87
P ++ G+ V+Q + G KH ++T DG++++FG + G + + +S P A
Sbjct: 4125 PRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNGDY--GRLGLGNTSNKKLPERVTA 4182
Query: 88 LVGQYVITVATGSFHSGAVT-DNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
L G + VA G H+ AV+ D + + +G+ G+ + N P + +
Sbjct: 4183 LEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDV------- 4235
Query: 147 LLAVRILQLACGEEHTLALSISREIWAWGTGCQLGLIT-TAFPVTKPQKVEHLAGRVVLQ 205
L + I ++ACG + ++AL+ ++ +G +GL A +PQ++ LAG ++
Sbjct: 4236 LCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIED 4295
Query: 206 VACGAFHSLAL 216
VA GA H+LAL
Sbjct: 4296 VAVGAEHTLAL 4306
Score = 69.7 bits (169), Expect = 2e-11
Identities = 56/174 (32%), Positives = 86/174 (49%), Gaps = 17/174 (9%)
Query: 52 HGVLLTEDGEVYSFGTLPWRSGPVEICPSS----PILENALVGQYVITVATGSFHSGAVT 107
H + LTE GEV+S+G + G + S P AL G+ V+ ++ G HS VT
Sbjct: 4093 HSMALTESGEVFSWGDGDY--GKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVT 4150
Query: 108 DNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSI 167
+G + +G G+ + N P V+ + +I Q+ACG HTLA+S
Sbjct: 4151 SDGKLFTFGNGDYGRLGLGNTSNKKLPERVTALEG-------YQIGQVACGLNHTLAVSA 4203
Query: 168 SRE-IWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
+WA+G G +LGL + + PQK++ L G + +VACG S+AL +
Sbjct: 4204 DGSMVWAFGDGDYGKLGLGNSTAK-SSPQKIDVLCGIGIKKVACGTQFSVALTK 4256
Score = 68.9 bits (167), Expect = 4e-11
Identities = 65/227 (28%), Positives = 99/227 (43%), Gaps = 34/227 (14%)
Query: 52 HGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAV 106
H + T +GEV+S +G L + + P +++ L G+ V+ V+ G HS AV
Sbjct: 469 HTLAFTTEGEVFSWGDGDYGKLGHGNSSTQKYPK--LIQGPLQGKVVVCVSAGYRHSAAV 526
Query: 107 TDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALS 166
T++G Y WGE G+ + P V + + +++CG HT+ALS
Sbjct: 527 TEDGELYTWGEGDFGRLGHGDSNSRNIPTLVKDISN---------VGEVSCGSSHTIALS 577
Query: 167 -ISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ----- 218
R +W++G G +LG T V KP+ +E L G + +V G+ SLAL
Sbjct: 578 KDGRTVWSFGGGDNGKLGHGDTN-RVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVY 636
Query: 219 ------CLPSQDLKPVPERCNQCSQLLITMTDKEDHVIISDSHCCPL 259
CL + R +L T + V I DSHC L
Sbjct: 637 AWGCGACLGCGSSEATALRPKLIEELAAT---RIVDVSIGDSHCLAL 680
Score = 66.2 bits (160), Expect = 2e-10
Identities = 58/189 (30%), Positives = 90/189 (47%), Gaps = 13/189 (6%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGE-VYSFGTLPWRSGPV--EICPSSPILENAL 88
PER+ G + Q A G+ H + ++ DG V++FG + + SSP + L
Sbjct: 4177 PERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGDGDYGKLGLGNSTAKSSPQKIDVL 4236
Query: 89 VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLL 148
G + VA G+ S A+T +G Y +G++ + P + + L
Sbjct: 4237 CGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPV-------LA 4289
Query: 149 AVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQV 206
V I +A G EHTLAL+ + +++AWG+ QLGL T V +P V L G+ V Q+
Sbjct: 4290 GVIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNH-VREPTLVTGLQGKNVRQI 4348
Query: 207 ACGAFHSLA 215
+ G HS A
Sbjct: 4349 SAGRCHSAA 4357
Score = 63.9 bits (154), Expect = 1e-09
Identities = 49/183 (26%), Positives = 89/183 (48%), Gaps = 18/183 (9%)
Query: 40 GKTVLQAALGVKHGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVI 94
GK V+ + G +H +TEDGE+Y+ FG L P+ + + + VG+
Sbjct: 510 GKVVVCVSAGYRHSAAVTEDGELYTWGEGDFGRLGHGDSNSRNIPTL-VKDISNVGE--- 565
Query: 95 TVATGSFHSGAVTDNG-VAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRIL 153
V+ GS H+ A++ +G + +G G+ + V +P + L + I
Sbjct: 566 -VSCGSSHTIALSKDGRTVWSFGGGDNGKLGHGDTNRVYKPKVIEA-------LQGMFIR 617
Query: 154 QLACGEEHTLALSISREIWAWGTGCQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
++ G + +LAL+ + +++AWG G LG ++ +P+ +E LA ++ V+ G H
Sbjct: 618 KVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAATRIVDVSIGDSHC 677
Query: 214 LAL 216
LAL
Sbjct: 678 LAL 680
Score = 59.3 bits (142), Expect = 3e-08
Identities = 32/98 (32%), Positives = 50/98 (51%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
VW++G G G+LGHGD +P ++ L G + + AG SLALT+ QVY+WG
Sbjct: 583 VWSFGGGDNGKLGHGDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGA 642
Query: 588 FGQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLFL 625
G S+ P+L + + + ++ G + L L
Sbjct: 643 CLGCGSSEATALRPKLIEELAATRIVDVSIGDSHCLAL 680
Score = 57.0 bits (136), Expect = 1e-07
Identities = 23/66 (34%), Positives = 44/66 (66%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
EV++WG G G+LGHG+ + +P ++ L G+EV+ + G HS +T+ +++++G+
Sbjct: 4102 EVFSWGDGDYGKLGHGNSDRQRRPRQIEALQGEEVVQMSCGFKHSAVVTSDGKLFTFGNG 4161
Query: 587 TFGQLG 592
+G+LG
Sbjct: 4162 DYGRLG 4167
Score = 56.2 bits (134), Expect = 3e-07
Identities = 41/140 (29%), Positives = 64/140 (45%), Gaps = 17/140 (12%)
Query: 31 TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-----LPWRSGPVEICPSS-PIL 84
+P+++ G + + A G + V LT+DG VY+FG LP P P+L
Sbjct: 4229 SPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDRLIGLPEGRARNHNRPQQIPVL 4288
Query: 85 ENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEA 144
++ VA G+ H+ A+ NG Y WG NS GQ + + +V EP V
Sbjct: 4289 AGVIIED----VAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLV------- 4337
Query: 145 SPLLAVRILQLACGEEHTLA 164
+ L + Q++ G H+ A
Sbjct: 4338 TGLQGKNVRQISAGRCHSAA 4357
Score = 55.5 bits (132), Expect = 4e-07
Identities = 41/148 (27%), Positives = 64/148 (43%), Gaps = 12/148 (8%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS-GPVEICPSSPILENALVG 90
P+ + G + + G + + LT G+VY++G G E P L L
Sbjct: 605 PKVIEALQGMFIRKVCAGSQSSLALTSTGQVYAWGCGACLGCGSSEATALRPKLIEELAA 664
Query: 91 QYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQ-YVPEPNPVSIADSEASPLLA 149
++ V+ G H A++ + Y WG NS GQC N + +P VS D
Sbjct: 665 TRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPKKVSGLD-------G 717
Query: 150 VRILQLACGEEHTL---ALSISREIWAW 174
+ I Q++ G H+L AL R++ AW
Sbjct: 718 IAIQQISAGTSHSLAWTALPRDRQVVAW 745
Score = 55.1 bits (131), Expect = 6e-07
Identities = 37/149 (24%), Positives = 68/149 (45%), Gaps = 16/149 (10%)
Query: 477 GGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKE 536
G + R+ P ++ + +RK ++ LT T +V+ WG G
Sbjct: 597 GDTNRVYKPKVIEALQGMFIRKVCAGSQSSLALTST-------------GQVYAWGCGAC 643
Query: 537 GQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF 596
G + L+P ++ L ++ + G H LAL+ ++VY+WG+N+ GQ G +
Sbjct: 644 LGCGSSEATA-LRPKLIEELAATRIVDVSIGDSHCLALSHDNEVYAWGNNSMGQCGQGNS 702
Query: 597 PTTVPRLAKISSENG--VWSIAAGRDYSL 623
+ + K+S +G + I+AG +SL
Sbjct: 703 TGPITKPKKVSGLDGIAIQQISAGTSHSL 731
Score = 48.1 bits (113), Expect = 7e-05
Identities = 49/164 (29%), Positives = 81/164 (49%), Gaps = 18/164 (10%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAK-SQVYSWGS 585
+++T+G G G+LG G+ + P V L+G ++ + G H+LA++A S V+++G
Sbjct: 4154 KLFTFGNGDYGRLGLGNTSNKKLPERVTALEGYQIGQVACGLNHTLAVSADGSMVWAFGD 4213
Query: 586 NTFGQLG-HSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPT 644
+G+LG + + P+ + G+ +A G +S+ L T+D G Y+ QD
Sbjct: 4214 GDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVAL--TKD---GHVYTFGQDRL 4268
Query: 645 EGDNLPE----NHS-GSKTPVLLSCSKLGYISRVTAGKDSYLAL 683
G LPE NH+ + PVL I V G + LAL
Sbjct: 4269 IG--LPEGRARNHNRPQQIPVLAGV----IIEDVAVGAEHTLAL 4306
Score = 46.2 bits (108), Expect = 3e-04
Identities = 34/100 (34%), Positives = 48/100 (48%), Gaps = 9/100 (9%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
V+T+G+ + L G +P + L G + + G H+LAL + VY+WGSN+
Sbjct: 4260 VYTFGQDRLIGLPEGRARNHNRPQQIPVLAGVIIEDVAVGAEHTLALASNGDVYAWGSNS 4319
Query: 588 FGQLG-----HSDFPTTVPRLAKISSENGVWSIAAGRDYS 622
GQLG H PT V L V I+AGR +S
Sbjct: 4320 EGQLGLGHTNHVREPTLVTGL----QGKNVRQISAGRCHS 4355
Score = 44.3 bits (103), Expect = 0.001
Identities = 43/141 (30%), Positives = 60/141 (42%), Gaps = 13/141 (9%)
Query: 493 PRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVL-PRLQPL 551
P+L+ + A + V + G++ L S EV+ WG GQ G G+ P +P
Sbjct: 656 PKLIEELAATRIVDVSI-----GDSHCLALSHDNEVYAWGNNSMGQCGQGNSTGPITKPK 710
Query: 552 CVKCLDGKEVIHLEAGGYHSLALTA---KSQVYSWGSNTFGQLGHSDFPTTVPRLA---- 604
V LDG + + AG HSLA TA QV +W L S F L
Sbjct: 711 KVSGLDGIAIQQISAGTSHSLAWTALPRDRQVVAWHRPYCVDLEESTFSHLRSFLERYCD 770
Query: 605 KISSENGVWSIAAGRDYSLFL 625
KI+SE + R++ FL
Sbjct: 771 KINSEIPPLPFPSSREHHSFL 791
Score = 44.3 bits (103), Expect = 0.001
Identities = 30/108 (27%), Positives = 51/108 (47%), Gaps = 9/108 (8%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
VW +G G G+LG G+ + P + L G + + G S+ALT VY++G +
Sbjct: 4208 VWAFGDGDYGKLGLGNSTAKSSPQKIDVLCGIGIKKVACGTQFSVALTKDGHVYTFGQDR 4267
Query: 588 F-----GQLGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTED 630
G+ + + P +P LA + E+ +A G +++L L D
Sbjct: 4268 LIGLPEGRARNHNRPQQIPVLAGVIIED----VAVGAEHTLALASNGD 4311
Score = 42.7 bits (99), Expect = 0.003
Identities = 25/70 (35%), Positives = 32/70 (45%)
Query: 507 VVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEA 566
V++ G L + +V+ WG EGQLG G +P V L GK V + A
Sbjct: 4291 VIIEDVAVGAEHTLALASNGDVYAWGSNSEGQLGLGHTNHVREPTLVTGLQGKNVRQISA 4350
Query: 567 GGYHSLALTA 576
G HS A TA
Sbjct: 4351 GRCHSAAWTA 4360
Score = 42.0 bits (97), Expect = 0.005
Identities = 47/160 (29%), Positives = 75/160 (46%), Gaps = 19/160 (11%)
Query: 532 GKGKEGQLGHGD-----VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
GKG G+LG GD L +L + + K+V + H+LA T + +V+SWG
Sbjct: 428 GKGSYGRLGLGDSNNQSTLKKLTFEPHRSI--KKVSSSKGSDGHTLAFTTEGEVFSWGDG 485
Query: 587 TFGQLGHSDFPT-TVPRLAKISSENG-VWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPT 644
+G+LGH + T P+L + + V ++AG +S + TED + LY G
Sbjct: 486 DYGKLGHGNSSTQKYPKLIQGPLQGKVVVCVSAGYRHSAAV--TEDGE--LYTWG----- 536
Query: 645 EGDNLPENHSGSKTPVLLSCSK-LGYISRVTAGKDSYLAL 683
EGD H S + + + K + + V+ G +AL
Sbjct: 537 EGDFGRLGHGDSNSRNIPTLVKDISNVGEVSCGSSHTIAL 576
Score = 41.2 bits (95), Expect = 0.008
Identities = 23/67 (34%), Positives = 33/67 (49%), Gaps = 3/67 (4%)
Query: 532 GKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAG---GYHSLALTAKSQVYSWGSNTF 588
G+G G+LG G+ + L G V L HS+ALT +V+SWG +
Sbjct: 4052 GEGSYGRLGQGNSDDLHVLTVISALQGFVVTQLVTSCGSDGHSMALTESGEVFSWGDGDY 4111
Query: 589 GQLGHSD 595
G+LGH +
Sbjct: 4112 GKLGHGN 4118
Score = 38.1 bits (87), Expect = 0.071
Identities = 24/78 (30%), Positives = 34/78 (43%), Gaps = 2/78 (2%)
Query: 518 DALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAK 577
DA + S EV+ WG QL G LQP + I EAG Y + ++
Sbjct: 364 DAPIVSETCEVYVWGSNSSHQLVEGTQEKILQPKLAPSFSDAQTI--EAGQYCTFVISTD 421
Query: 578 SQVYSWGSNTFGQLGHSD 595
V + G ++G+LG D
Sbjct: 422 GSVRACGKGSYGRLGLGD 439
Score = 31.6 bits (70), Expect = 6.7
Identities = 20/67 (29%), Positives = 30/67 (44%), Gaps = 3/67 (4%)
Query: 1241 NGDYIEGYFSGEWGSG---IKITGTYFKPSLYESDKDRPKVFRKLGNLAVPADEKWKAVF 1297
NG Y++G+F GE GSG + GT + L K + + A K +V+
Sbjct: 3014 NGSYVDGWFGGECGSGNPYYLLCGTCREKYLAMKTKSKSTSSERYKGQAPDLIGKQDSVY 3073
Query: 1298 DECWRQL 1304
+E W L
Sbjct: 3074 EEDWDML 3080
>gi|50355990 MORN repeat containing 3 [Homo sapiens]
Length = 240
Score = 74.3 bits (181), Expect = 9e-13
Identities = 50/169 (29%), Positives = 77/169 (45%), Gaps = 10/169 (5%)
Query: 1049 YDGRWLSGKPHGRGVLKW-PDGKMYSGMFRNGLEDGYGEYRIPNKAMNK-EDHYVGHWKE 1106
Y G W HG+G W G +Y G ++ G DGYG +P++ K Y G WK
Sbjct: 38 YVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKG 97
Query: 1107 GKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVF 1166
K G G+ + E +EG + + R G G++ S+ ++ GQW DK G G+
Sbjct: 98 DKKSGYGIQFFGPKEYYEGDWCGSQRSGW-----GRMYYSNGDIYEGQWENDKPNGEGML 152
Query: 1167 DDITRGEKYMGMWQDDVCQGNG-VVVTQFGLYYEGNFHLNKMMGNGVLL 1214
+ G +Y G W+ + G G G +EG F ++ M G ++
Sbjct: 153 -RLKNGNRYEGCWERGMKNGAGRFFHLDHGQLFEG-FWVDNMAKCGTMI 199
Score = 71.6 bits (174), Expect = 6e-12
Identities = 41/147 (27%), Positives = 72/147 (48%), Gaps = 16/147 (10%)
Query: 1045 KDATYDGRWLSGKPHGRGVLKWPDG------KMYSGMFRNGLEDGYGEYRIPNKAMNKED 1098
K A Y+G W GK G G L PD ++YSG ++ + GYG + ++
Sbjct: 58 KGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWWKGDKKSGYGI-----QFFGPKE 112
Query: 1099 HYVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMD 1158
+Y G W + G G Y++G+++EG ++++ +G G+LR + + + G W
Sbjct: 113 YYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRL-----KNGNRYEGCWERG 167
Query: 1159 KKAGYGVFDDITRGEKYMGMWQDDVCQ 1185
K G G F + G+ + G W D++ +
Sbjct: 168 MKNGAGRFFHLDHGQLFEGFWVDNMAK 194
Score = 62.0 bits (149), Expect = 5e-09
Identities = 42/145 (28%), Positives = 72/145 (49%), Gaps = 14/145 (9%)
Query: 1119 SGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFD--DITRGE--- 1173
+G+ + G ++DN++HG G ++ +++ G W K+ GYG D G+
Sbjct: 34 NGDYYVGEWEDNVKHGKGT----QVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRR 89
Query: 1174 KYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSG 1233
Y G W+ D G G+ YYEG++ ++ G G + + IYEG++ +D +G
Sbjct: 90 VYSGWWKGDKKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWEND-KPNG 148
Query: 1234 KGTLTMPNGDYIEGYFSGEWGSGIK 1258
+G L + NG+ EG W G+K
Sbjct: 149 EGMLRLKNGNRYEGC----WERGMK 169
Score = 62.0 bits (149), Expect = 5e-09
Identities = 43/154 (27%), Positives = 69/154 (44%), Gaps = 3/154 (1%)
Query: 1098 DHYVGHWKEGKMCGQGVYSYAS-GEVFEGCFQDNMRHGHGLLR-SGKLTSSSPSMFIGQW 1155
D+YVG W++ G+G + G ++EG ++ R G+G L + T ++ G W
Sbjct: 36 DYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGWW 95
Query: 1156 VMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLS 1215
DKK+GYG+ E Y G W G G + G YEG + +K G G+L
Sbjct: 96 KGDKKSGYGI-QFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYEGQWENDKPNGEGMLRL 154
Query: 1216 EDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYF 1249
++ YEG + + +G EG++
Sbjct: 155 KNGNRYEGCWERGMKNGAGRFFHLDHGQLFEGFW 188
Score = 44.3 bits (103), Expect = 0.001
Identities = 24/103 (23%), Positives = 45/103 (43%), Gaps = 27/103 (26%)
Query: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGK 1108
Y+G+W + KP+G G+L+ +G Y G + G+++G G +
Sbjct: 137 YEGQWENDKPNGEGMLRLKNGNRYEGCWERGMKNGAGRF--------------------- 175
Query: 1109 MCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMF 1151
+ G++FEG + DNM ++ G+ + P+ F
Sbjct: 176 ------FHLDHGQLFEGFWVDNMAKCGTMIDFGRDEAPEPTQF 212
Score = 42.0 bits (97), Expect = 0.005
Identities = 36/124 (29%), Positives = 53/124 (42%), Gaps = 13/124 (10%)
Query: 1172 GEKYMGMWQDDVCQGNGVVV-TQFGLYYEGNFHLNKMMGNGVLLSEDD------TIYEGE 1224
G+ Y+G W+D+V G G V + G YEG++ K G G L D +Y G
Sbjct: 35 GDYYVGEWEDNVKHGKGTQVWKKKGAIYEGDWKFGKRDGYGTLSLPDQQTGKCRRVYSGW 94
Query: 1225 FSDDWTLSGKGTLTMPNGDYIEGYFSGE----WGSGIKITGTYFKPSLYESDKDRPKVFR 1280
+ D SG G +Y EG + G WG G ++ +E+DK +
Sbjct: 95 WKGD-KKSGYGIQFFGPKEYYEGDWCGSQRSGWGRMYYSNGDIYE-GQWENDKPNGEGML 152
Query: 1281 KLGN 1284
+L N
Sbjct: 153 RLKN 156
>gi|4506581 retinitis pigmentosa GTPase regulator isoform A [Homo
sapiens]
Length = 815
Score = 73.6 bits (179), Expect = 2e-12
Identities = 44/173 (25%), Positives = 88/173 (50%), Gaps = 9/173 (5%)
Query: 43 VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFH 102
+ Q + G LTEDG ++ +G ++ + + + +G+ V ++ G +H
Sbjct: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYH 201
Query: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162
S VT +G Y++GE G+ + NQ P +++ + +++Q+ACG EHT
Sbjct: 202 SAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE------IPEKVIQVACGGEHT 255
Query: 163 LALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
+ L+ ++ +G G QLGL T F ++P+ +E++ + + ++CG H+
Sbjct: 256 VVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
Score = 49.7 bits (117), Expect = 2e-05
Identities = 69/284 (24%), Positives = 119/284 (41%), Gaps = 26/284 (9%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLAL 574
G+ + + + +++ +G GQLG G +P CVK L ++V G H+L
Sbjct: 43 GDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS 102
Query: 575 TAKSQVYSWGSNTFGQLGHSDFP--TTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
T VY+ G N GQLG D T ++ +SE+ + ++AG + S L TED +
Sbjct: 103 TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL--TEDGR 160
Query: 633 PGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSK------LGYISRVTAGKDSYLALVDK 686
L+ G D +EG +N S P ++ K GY D L + +
Sbjct: 161 --LFMWG--DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGE 216
Query: 687 NIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFSKLC 746
G + ++L R +S+I ++++ E+ TV L + F
Sbjct: 217 PENGKLGLPNQLLGNHRT-PQLVSEIPEKVIQVACGGEH-----TVVLTENAVYTFG--- 267
Query: 747 YLIGQHG-ASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSI 789
+GQ G L +FL E + + ++ ++ S E T++
Sbjct: 268 --LGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTAL 309
Score = 45.4 bits (106), Expect = 4e-04
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 25/170 (14%)
Query: 55 LLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYM 114
L+ + G V++FG +S E P +N + + ++ G HS VT N YM
Sbjct: 7 LMPDSGAVFTFG----KSKFAENNPGKFWFKNDVP----VHLSCGDEHSAVVTGNNKLYM 58
Query: 115 WGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAW 174
+G N+ GQ + ++ + +P V E ++ ACG HTL + ++A
Sbjct: 59 FGSNNWGQLGLGSKSAISKPTCVKALKPE-------KVKLAACGRNHTLVSTEGGNVYAT 111
Query: 175 G--TGCQLGLITT----AFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
G QLGL T F V EH + Q++ G+ S AL +
Sbjct: 112 GGNNEGQLGLGDTEERNTFHVISFFTSEH----KIKQLSAGSNTSAALTE 157
Score = 43.9 bits (102), Expect = 0.001
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 35/190 (18%)
Query: 40 GKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQY------- 92
GK V + G H +T DGE+Y FG +G + L N L+G +
Sbjct: 189 GKPVSWISCGYYHSAFVTTDGELYVFGEP--ENGKLG-------LPNQLLGNHRTPQLVS 239
Query: 93 -----VITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQY-VPEPNPV-SIADSEAS 145
VI VA G H+ +T+N V Y +G GQ + + EP + +I D S
Sbjct: 240 EIPEKVIQVACGGEHTVVLTENAV-YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTIS 298
Query: 146 PLLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFP-VTKPQKVEHLAGRV 202
++CGE HT ++ ++ +G G +LGL F P + +
Sbjct: 299 --------YISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI 350
Query: 203 VLQVACGAFH 212
V VACG H
Sbjct: 351 VKLVACGGCH 360
Score = 40.4 bits (93), Expect = 0.014
Identities = 25/69 (36%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 562 IHLEAGGYHSLALTAKSQVYSWGSNTFGQLG-HSDFPTTVPRLAKISSENGVWSIAAGRD 620
+HL G HS +T +++Y +GSN +GQLG S + P K V A GR+
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 621 YSLFLVDTE 629
++ LV TE
Sbjct: 98 HT--LVSTE 104
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 73.6 bits (179), Expect = 2e-12
Identities = 44/173 (25%), Positives = 88/173 (50%), Gaps = 9/173 (5%)
Query: 43 VLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFH 102
+ Q + G LTEDG ++ +G ++ + + + +G+ V ++ G +H
Sbjct: 142 IKQLSAGSNTSAALTEDGRLFMWGDNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYH 201
Query: 103 SGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHT 162
S VT +G Y++GE G+ + NQ P +++ + +++Q+ACG EHT
Sbjct: 202 SAFVTTDGELYVFGEPENGKLGLPNQLLGNHRTPQLVSE------IPEKVIQVACGGEHT 255
Query: 163 LALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHS 213
+ L+ ++ +G G QLGL T F ++P+ +E++ + + ++CG H+
Sbjct: 256 VVLT-ENAVYTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHT 307
Score = 49.7 bits (117), Expect = 2e-05
Identities = 69/284 (24%), Positives = 119/284 (41%), Gaps = 26/284 (9%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLAL 574
G+ + + + +++ +G GQLG G +P CVK L ++V G H+L
Sbjct: 43 GDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRNHTLVS 102
Query: 575 TAKSQVYSWGSNTFGQLGHSDFP--TTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
T VY+ G N GQLG D T ++ +SE+ + ++AG + S L TED +
Sbjct: 103 TEGGNVYATGGNNEGQLGLGDTEERNTFHVISFFTSEHKIKQLSAGSNTSAAL--TEDGR 160
Query: 633 PGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSK------LGYISRVTAGKDSYLALVDK 686
L+ G D +EG +N S P ++ K GY D L + +
Sbjct: 161 --LFMWG--DNSEGQIGLKNVSNVCVPQQVTIGKPVSWISCGYYHSAFVTTDGELYVFGE 216
Query: 687 NIMGYIASLHELATTERRFYSKLSDIKSQILRPLLSLENLGTTTTVQLLQEVASRFSKLC 746
G + ++L R +S+I ++++ E+ TV L + F
Sbjct: 217 PENGKLGLPNQLLGNHRT-PQLVSEIPEKVIQVACGGEH-----TVVLTENAVYTFG--- 267
Query: 747 YLIGQHG-ASLSSFLHGVKEARSLVILKHSSLFLDSYTEYCTSI 789
+GQ G L +FL E + + ++ ++ S E T++
Sbjct: 268 --LGQFGQLGLGTFLFETSEPKVIENIRDQTISYISCGENHTAL 309
Score = 45.4 bits (106), Expect = 4e-04
Identities = 46/170 (27%), Positives = 73/170 (42%), Gaps = 25/170 (14%)
Query: 55 LLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYM 114
L+ + G V++FG +S E P +N + + ++ G HS VT N YM
Sbjct: 7 LMPDSGAVFTFG----KSKFAENNPGKFWFKNDVP----VHLSCGDEHSAVVTGNNKLYM 58
Query: 115 WGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAW 174
+G N+ GQ + ++ + +P V E ++ ACG HTL + ++A
Sbjct: 59 FGSNNWGQLGLGSKSAISKPTCVKALKPE-------KVKLAACGRNHTLVSTEGGNVYAT 111
Query: 175 G--TGCQLGLITT----AFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
G QLGL T F V EH + Q++ G+ S AL +
Sbjct: 112 GGNNEGQLGLGDTEERNTFHVISFFTSEH----KIKQLSAGSNTSAALTE 157
Score = 43.9 bits (102), Expect = 0.001
Identities = 53/190 (27%), Positives = 78/190 (41%), Gaps = 35/190 (18%)
Query: 40 GKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQY------- 92
GK V + G H +T DGE+Y FG +G + L N L+G +
Sbjct: 189 GKPVSWISCGYYHSAFVTTDGELYVFGEP--ENGKLG-------LPNQLLGNHRTPQLVS 239
Query: 93 -----VITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQY-VPEPNPV-SIADSEAS 145
VI VA G H+ +T+N V Y +G GQ + + EP + +I D S
Sbjct: 240 EIPEKVIQVACGGEHTVVLTENAV-YTFGLGQFGQLGLGTFLFETSEPKVIENIRDQTIS 298
Query: 146 PLLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFP-VTKPQKVEHLAGRV 202
++CGE HT ++ ++ +G G +LGL F P + +
Sbjct: 299 --------YISCGENHTALITDIGLMYTFGDGRHGKLGLGLENFTNHFIPTLCSNFLRFI 350
Query: 203 VLQVACGAFH 212
V VACG H
Sbjct: 351 VKLVACGGCH 360
Score = 40.4 bits (93), Expect = 0.014
Identities = 25/69 (36%), Positives = 36/69 (52%), Gaps = 3/69 (4%)
Query: 562 IHLEAGGYHSLALTAKSQVYSWGSNTFGQLG-HSDFPTTVPRLAKISSENGVWSIAAGRD 620
+HL G HS +T +++Y +GSN +GQLG S + P K V A GR+
Sbjct: 38 VHLSCGDEHSAVVTGNNKLYMFGSNNWGQLGLGSKSAISKPTCVKALKPEKVKLAACGRN 97
Query: 621 YSLFLVDTE 629
++ LV TE
Sbjct: 98 HT--LVSTE 104
>gi|110825982 hect domain and RLD 5 [Homo sapiens]
Length = 1024
Score = 72.8 bits (177), Expect = 3e-12
Identities = 53/185 (28%), Positives = 94/185 (50%), Gaps = 13/185 (7%)
Query: 41 KTVLQAALGVKHGVLLTEDGEVYSFG-TLPWRSGPVEICPSS--PILENALVGQYVITVA 97
K ++Q G H + L++ GE++++G L + G PS+ P + L G + ++
Sbjct: 138 KKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQIS 197
Query: 98 TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
G HS A++ +G Y WG+N GQ + + + +P+ + D++ ++ +AC
Sbjct: 198 AGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQ-------KVEFVAC 250
Query: 158 GEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLA 215
G H+ L+ ++ +G G QLG +T + +P V L G V Q+ACG +H+LA
Sbjct: 251 GGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNEL-RPCLVAELVGYRVTQIACGRWHTLA 309
Query: 216 LVQCL 220
V L
Sbjct: 310 YVSDL 314
Score = 70.1 bits (170), Expect = 2e-11
Identities = 51/172 (29%), Positives = 80/172 (46%), Gaps = 18/172 (10%)
Query: 49 GVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTD 108
G +H ++L+ DG+ + + + E+ L + +I + G +HS A++
Sbjct: 105 GAEHMLILSSDGKPFEYDNYSMKHLR---------FESILQEKKIIQITCGDYHSLALSK 155
Query: 109 NGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSIS 168
G + WG+N GQ V + P + L V + Q++ GE H++ALS+S
Sbjct: 156 GGELFAWGQNLHGQLGVGRK------FPSTTTPQIVEHLAGVPLAQISAGEAHSMALSMS 209
Query: 169 REIWAWGTG-C-QLGLITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALVQ 218
I++WG C QLGL T P +E L + V VACG HS L Q
Sbjct: 210 GNIYSWGKNECGQLGLGHTE-SKDDPSLIEGLDNQKVEFVACGGSHSALLTQ 260
Score = 61.6 bits (148), Expect = 6e-09
Identities = 39/121 (32%), Positives = 62/121 (51%), Gaps = 1/121 (0%)
Query: 507 VVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEA 566
V L +GEA ++ S+ +++WGK + GQLG G + P ++ LD ++V +
Sbjct: 191 VPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTESKDDPSLIEGLDNQKVEFVAC 250
Query: 567 GGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV-PRLAKISSENGVWSIAAGRDYSLFL 625
GG HS LT ++++G+ GQLGH+ + P L V IA GR ++L
Sbjct: 251 GGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAY 310
Query: 626 V 626
V
Sbjct: 311 V 311
Score = 58.9 bits (141), Expect = 4e-08
Identities = 51/174 (29%), Positives = 80/174 (45%), Gaps = 12/174 (6%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQ-PLCVKCLDGKEVIHLEAGGYHSLA 573
G+ +L S E++ WG+ GQLG G P P V+ L G + + AG HS+A
Sbjct: 146 GDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLAQISAGEAHSMA 205
Query: 574 LTAKSQVYSWGSNTFGQ--LGHSDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDF 631
L+ +YSWG N GQ LGH++ P L + V +A G +S L T+D
Sbjct: 206 LSMSGNIYSWGKNECGQLGLGHTESKDD-PSLIEGLDNQKVEFVACGGSHSALL--TQDG 262
Query: 632 QPGLYYSGRQDPTEGDNLPENHSGSKTPVLLSCSKLGY-ISRVTAGKDSYLALV 684
+ +G+ L N + ++ L +GY ++++ G+ LA V
Sbjct: 263 LLFTFGAGKH-----GQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYV 311
Score = 55.5 bits (132), Expect = 4e-07
Identities = 45/151 (29%), Positives = 71/151 (47%), Gaps = 12/151 (7%)
Query: 31 TPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENA 87
TP+ + G + Q + G H + L+ G +YS+G G E P L
Sbjct: 181 TPQIVEHLAGVPLAQISAGEAHSMALSMSGNIYSWGKNECGQLGLGHTE-SKDDPSLIEG 239
Query: 88 LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
L Q V VA G HS +T +G+ + +G GQ + Q E P +A+ L
Sbjct: 240 LDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQ--NELRPCLVAE-----L 292
Query: 148 LAVRILQLACGEEHTLA-LSISREIWAWGTG 177
+ R+ Q+ACG HTLA +S +++++G+G
Sbjct: 293 VGYRVTQIACGRWHTLAYVSDLGKVFSFGSG 323
Score = 50.4 bits (119), Expect = 1e-05
Identities = 31/83 (37%), Positives = 45/83 (54%), Gaps = 2/83 (2%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAK-SQVYSWGSN 586
++T+G GK GQLGH L+P V L G V + G +H+LA + +V+S+GS
Sbjct: 264 LFTFGAGKHGQLGHNSTQNELRPCLVAELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSG 323
Query: 587 TFGQLGHSDF-PTTVPRLAKISS 608
GQLG+ +P K+SS
Sbjct: 324 KDGQLGNGGTRDQLMPLPVKVSS 346
Score = 48.9 bits (115), Expect = 4e-05
Identities = 27/72 (37%), Positives = 43/72 (59%), Gaps = 2/72 (2%)
Query: 556 LDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLG-HSDFP-TTVPRLAKISSENGVW 613
L K++I + G YHSLAL+ ++++WG N GQLG FP TT P++ + + +
Sbjct: 135 LQEKKIIQITCGDYHSLALSKGGELFAWGQNLHGQLGVGRKFPSTTTPQIVEHLAGVPLA 194
Query: 614 SIAAGRDYSLFL 625
I+AG +S+ L
Sbjct: 195 QISAGEAHSMAL 206
Score = 47.0 bits (110), Expect = 2e-04
Identities = 43/148 (29%), Positives = 65/148 (43%), Gaps = 12/148 (8%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-----LPWRSGPVEICPSSPILEN 86
P + G + V A G H LLT+DG +++FG L S E+ P L
Sbjct: 234 PSLIEGLDNQKVEFVACGGSHSALLTQDGLLFTFGAGKHGQLGHNSTQNEL---RPCLVA 290
Query: 87 ALVGQYVITVATGSFHSGA-VTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEAS 145
LVG V +A G +H+ A V+D G + +G GQ + P PV ++ SE
Sbjct: 291 ELVGYRVTQIACGRWHTLAYVSDLGKVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEEL 350
Query: 146 PL---LAVRILQLACGEEHTLALSISRE 170
L + + L + G ++ L I +E
Sbjct: 351 KLESHTSEKELIMIAGGNQSILLWIKKE 378
Score = 35.8 bits (81), Expect = 0.35
Identities = 21/63 (33%), Positives = 34/63 (53%), Gaps = 10/63 (15%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEV----------IHLEAGGYHSLALTA 576
+V+++G GK+GQLG+G +L PL VK +E+ + + AGG S+ L
Sbjct: 316 KVFSFGSGKDGQLGNGGTRDQLMPLPVKVSSSEELKLESHTSEKELIMIAGGNQSILLWI 375
Query: 577 KSQ 579
K +
Sbjct: 376 KKE 378
>gi|209969703 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 72.4 bits (176), Expect = 3e-12
Identities = 46/141 (32%), Positives = 75/141 (53%), Gaps = 8/141 (5%)
Query: 500 ARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGK 559
A V+ RTVV + S A +LL + ++W+WG+ ++GQLGHGD P ++ L +
Sbjct: 146 AGVRVRTVV---SGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
Query: 560 EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAG 618
++ G H+LALT V+++G N GQLG + VP A+I + + +A G
Sbjct: 203 VIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACG 262
Query: 619 RDYSLFLVDTEDFQPGLYYSG 639
++S+ + D + LY G
Sbjct: 263 AEFSMIM----DCKGNLYSFG 279
Score = 53.5 bits (127), Expect = 2e-06
Identities = 39/156 (25%), Positives = 71/156 (45%), Gaps = 17/156 (10%)
Query: 477 GGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKE 536
G ++R+ P L+ +S ++ AA + T+ LT T S V+ +G+ K
Sbjct: 185 GDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGS-------------VFAFGENKM 231
Query: 537 GQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF 596
GQLG G+ + +G+ + + G S+ + K +YS+G +GQLGH+
Sbjct: 232 GQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSD 291
Query: 597 PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
+ R +I + + R ++F+ T+D Q
Sbjct: 292 GKFIARAQRIEYDCEL----VPRRVAIFIEKTKDGQ 323
Score = 52.8 bits (125), Expect = 3e-06
Identities = 51/214 (23%), Positives = 93/214 (43%), Gaps = 45/214 (21%)
Query: 35 LPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS------SPILENAL 88
L G +TV+ + H +L+T +G+++S+G R+ ++ +P L L
Sbjct: 145 LAGVRVRTVVSGSCAA-HSLLITTEGKLWSWG----RNEKGQLGHGDTKRVEAPRLIEGL 199
Query: 89 VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQ-QYVPEPNPVSIADSEASPL 147
+ +++ A G H+ A+T+ G + +GEN GQ + NQ VP P +
Sbjct: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP---- 255
Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEH-------- 197
I ++ACG E ++ + ++++G QLG + + + Q++E+
Sbjct: 256 ----ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRR 311
Query: 198 ---------------LAGRVVLQVACGAFHSLAL 216
+ VV VACGA H+L L
Sbjct: 312 VAIFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
Score = 50.4 bits (119), Expect = 1e-05
Identities = 46/168 (27%), Positives = 72/168 (42%), Gaps = 25/168 (14%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS----GPVEICPS-SPILEN 86
P + G + ++ AA G H + LTE G V++FG + PS + I+ N
Sbjct: 193 PRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 252
Query: 87 ALVGQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQ--QYVPEPNP 136
GQ + +A G+ S + G Y +G NS G+ Q +Y E P
Sbjct: 253 ---GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVP 309
Query: 137 VSIA-------DSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG 177
+A D + P+ V + +ACG HTL L + +++WG G
Sbjct: 310 RRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357
Score = 41.6 bits (96), Expect = 0.006
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 25/123 (20%)
Query: 509 LTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHG----------------DVLPRLQPLC 552
+T G +++ + ++++G + GQLGH +++PR +
Sbjct: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 553 V-KCLDGK-------EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRL 603
+ K DG+ V + G H+L L ++ +V+SWG +G+LGH++ VPRL
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
Query: 604 AKI 606
K+
Sbjct: 376 VKL 378
Score = 39.7 bits (91), Expect = 0.025
Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 5/76 (6%)
Query: 147 LLAVRILQLACGE--EHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRV 202
L VR+ + G H+L ++ ++W+WG QLG T V P+ +E L+ V
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTK-RVEAPRLIEGLSHEV 203
Query: 203 VLQVACGAFHSLALVQ 218
++ ACG H+LAL +
Sbjct: 204 IVSAACGRNHTLALTE 219
Score = 38.5 bits (88), Expect = 0.055
Identities = 40/173 (23%), Positives = 61/173 (35%), Gaps = 49/173 (28%)
Query: 507 VVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHL 564
VV+ G L+ + V++WG G G+LGH + + P VK D G+ +
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQI 389
Query: 565 EAG---------------------------------------------GYHSLALTAKSQ 579
AG G S+ + A
Sbjct: 390 YAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADES 449
Query: 580 VYSWG-SNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTED 630
SWG S TFG+LG+ D P + ++ + +G++S YS LV D
Sbjct: 450 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
Score = 32.0 bits (71), Expect = 5.1
Identities = 49/200 (24%), Positives = 77/200 (38%), Gaps = 27/200 (13%)
Query: 43 VLQAALGVKHGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVITVA 97
V A G H ++L V+S +G L E+ P L + G+ +
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFD-FPGRGASQIY 390
Query: 98 TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
G S AV++ G + WG + + + Y P ++ D L RI LAC
Sbjct: 391 AGYTCSFAVSEVGGLFFWGATNTSR---ESTMY-----PKAVQD-----LCGWRIRSLAC 437
Query: 158 GEEHTLALSISREIWAWGTGCQLGLITTAF----PVTKPQKVEHLAGRVVLQVACGAFHS 213
G+ + + I +WG G + T Q+V+ L G QVA G HS
Sbjct: 438 GKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHS 496
Query: 214 LALVQC---LPSQDLKPVPE 230
L + + + +K +PE
Sbjct: 497 LVIARDESETEKEKIKKLPE 516
>gi|29789090 regulator of chromosome condensation 2 [Homo sapiens]
Length = 522
Score = 72.4 bits (176), Expect = 3e-12
Identities = 46/141 (32%), Positives = 75/141 (53%), Gaps = 8/141 (5%)
Query: 500 ARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGK 559
A V+ RTVV + S A +LL + ++W+WG+ ++GQLGHGD P ++ L +
Sbjct: 146 AGVRVRTVV---SGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTKRVEAPRLIEGLSHE 202
Query: 560 EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTVPRLAKIS-SENGVWSIAAG 618
++ G H+LALT V+++G N GQLG + VP A+I + + +A G
Sbjct: 203 VIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQPITKMACG 262
Query: 619 RDYSLFLVDTEDFQPGLYYSG 639
++S+ + D + LY G
Sbjct: 263 AEFSMIM----DCKGNLYSFG 279
Score = 53.5 bits (127), Expect = 2e-06
Identities = 39/156 (25%), Positives = 71/156 (45%), Gaps = 17/156 (10%)
Query: 477 GGSRRLSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKE 536
G ++R+ P L+ +S ++ AA + T+ LT T S V+ +G+ K
Sbjct: 185 GDTKRVEAPRLIEGLSHEVIVSAACGRNHTLALTETGS-------------VFAFGENKM 231
Query: 537 GQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDF 596
GQLG G+ + +G+ + + G S+ + K +YS+G +GQLGH+
Sbjct: 232 GQLGLGNQTDAVPSPAQIMYNGQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSD 291
Query: 597 PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTEDFQ 632
+ R +I + + R ++F+ T+D Q
Sbjct: 292 GKFIARAQRIEYDCEL----VPRRVAIFIEKTKDGQ 323
Score = 52.8 bits (125), Expect = 3e-06
Identities = 51/214 (23%), Positives = 93/214 (43%), Gaps = 45/214 (21%)
Query: 35 LPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS------SPILENAL 88
L G +TV+ + H +L+T +G+++S+G R+ ++ +P L L
Sbjct: 145 LAGVRVRTVVSGSCAA-HSLLITTEGKLWSWG----RNEKGQLGHGDTKRVEAPRLIEGL 199
Query: 89 VGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQ-QYVPEPNPVSIADSEASPL 147
+ +++ A G H+ A+T+ G + +GEN GQ + NQ VP P +
Sbjct: 200 SHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYNGQP---- 255
Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEH-------- 197
I ++ACG E ++ + ++++G QLG + + + Q++E+
Sbjct: 256 ----ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRR 311
Query: 198 ---------------LAGRVVLQVACGAFHSLAL 216
+ VV VACGA H+L L
Sbjct: 312 VAIFIEKTKDGQILPVPNVVVRDVACGANHTLVL 345
Score = 50.4 bits (119), Expect = 1e-05
Identities = 46/168 (27%), Positives = 72/168 (42%), Gaps = 25/168 (14%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRS----GPVEICPS-SPILEN 86
P + G + ++ AA G H + LTE G V++FG + PS + I+ N
Sbjct: 193 PRLIEGLSHEVIVSAACGRNHTLALTETGSVFAFGENKMGQLGLGNQTDAVPSPAQIMYN 252
Query: 87 ALVGQYVITVATGSFHSGAVTDNGVAYMWG--------ENSAGQCAVANQ--QYVPEPNP 136
GQ + +A G+ S + G Y +G NS G+ Q +Y E P
Sbjct: 253 ---GQPITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVP 309
Query: 137 VSIA-------DSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG 177
+A D + P+ V + +ACG HTL L + +++WG G
Sbjct: 310 RRVAIFIEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFG 357
Score = 41.6 bits (96), Expect = 0.006
Identities = 31/123 (25%), Positives = 58/123 (47%), Gaps = 25/123 (20%)
Query: 509 LTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHG----------------DVLPRLQPLC 552
+T G +++ + ++++G + GQLGH +++PR +
Sbjct: 256 ITKMACGAEFSMIMDCKGNLYSFGCPEYGQLGHNSDGKFIARAQRIEYDCELVPRRVAIF 315
Query: 553 V-KCLDGK-------EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD-FPTTVPRL 603
+ K DG+ V + G H+L L ++ +V+SWG +G+LGH++ VPRL
Sbjct: 316 IEKTKDGQILPVPNVVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRL 375
Query: 604 AKI 606
K+
Sbjct: 376 VKL 378
Score = 39.7 bits (91), Expect = 0.025
Identities = 25/76 (32%), Positives = 40/76 (52%), Gaps = 5/76 (6%)
Query: 147 LLAVRILQLACGE--EHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRV 202
L VR+ + G H+L ++ ++W+WG QLG T V P+ +E L+ V
Sbjct: 145 LAGVRVRTVVSGSCAAHSLLITTEGKLWSWGRNEKGQLGHGDTK-RVEAPRLIEGLSHEV 203
Query: 203 VLQVACGAFHSLALVQ 218
++ ACG H+LAL +
Sbjct: 204 IVSAACGRNHTLALTE 219
Score = 38.5 bits (88), Expect = 0.055
Identities = 40/173 (23%), Positives = 61/173 (35%), Gaps = 49/173 (28%)
Query: 507 VVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLD--GKEVIHL 564
VV+ G L+ + V++WG G G+LGH + + P VK D G+ +
Sbjct: 330 VVVRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFDFPGRGASQI 389
Query: 565 EAG---------------------------------------------GYHSLALTAKSQ 579
AG G S+ + A
Sbjct: 390 YAGYTCSFAVSEVGGLFFWGATNTSRESTMYPKAVQDLCGWRIRSLACGKSSIIVAADES 449
Query: 580 VYSWG-SNTFGQLGHSDF-PTTVPRLAKISSENGVWSIAAGRDYSLFLVDTED 630
SWG S TFG+LG+ D P + ++ + +G++S YS LV D
Sbjct: 450 TISWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHSLVIARD 502
Score = 32.0 bits (71), Expect = 5.1
Identities = 49/200 (24%), Positives = 77/200 (38%), Gaps = 27/200 (13%)
Query: 43 VLQAALGVKHGVLLTEDGEVYS-----FGTLPWRSGPVEICPSSPILENALVGQYVITVA 97
V A G H ++L V+S +G L E+ P L + G+ +
Sbjct: 332 VRDVACGANHTLVLDSQKRVFSWGFGGYGRLGHAEQKDEMVPRLVKLFD-FPGRGASQIY 390
Query: 98 TGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLAC 157
G S AV++ G + WG + + + Y P ++ D L RI LAC
Sbjct: 391 AGYTCSFAVSEVGGLFFWGATNTSR---ESTMY-----PKAVQD-----LCGWRIRSLAC 437
Query: 158 GEEHTLALSISREIWAWGTGCQLGLITTAF----PVTKPQKVEHLAGRVVLQVACGAFHS 213
G+ + + I +WG G + T Q+V+ L G QVA G HS
Sbjct: 438 GKSSIIVAADESTI-SWGPSPTFGELGYGDHKPKSSTAAQEVKTLDGIFSEQVAMGYSHS 496
Query: 214 LALVQC---LPSQDLKPVPE 230
L + + + +K +PE
Sbjct: 497 LVIARDESETEKEKIKKLPE 516
>gi|4557445 regulator of chromosome condensation and BTB domain
containing protein 2 [Homo sapiens]
Length = 551
Score = 72.0 bits (175), Expect = 4e-12
Identities = 60/193 (31%), Positives = 94/193 (48%), Gaps = 13/193 (6%)
Query: 30 ITPERLPGWGGKTVLQAALGV-KHGVLLTEDGEVYSFGTLPWR---SGPVEICPSSPILE 85
I P RL GK + + G H VL T +GEV+++G + +G +
Sbjct: 87 IEPRRLDSLNGKKIACLSYGSGPHIVLATTEGEVFTWGHNAYSQLGNGTTNHGLVPCHIS 146
Query: 86 NALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEAS 145
L + VI VA GS+HS +T +G + WG N++GQ V + V +P P + +
Sbjct: 147 TNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQ--VGSGSTVNQPIPRRVTGCLQN 204
Query: 146 PLLAVRILQLACGEEHTLALSISREIWAWG--TGCQLGLITTAFPVTKPQKVEHLAGRVV 203
+ ++ +ACG+ +A+ + E++ WG QLGL + T P +V L G V
Sbjct: 205 KV----VVTIACGQMCCMAVVDTGEVYVWGYNGNGQLGLGNSGNQPT-PCRVAALQGIRV 259
Query: 204 LQVACGAFHSLAL 216
+VACG H+L L
Sbjct: 260 QRVACGYAHTLVL 272
Score = 68.6 bits (166), Expect = 5e-11
Identities = 62/209 (29%), Positives = 93/209 (44%), Gaps = 15/209 (7%)
Query: 482 LSLPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGH 541
L L + S + PR L K + +Y +L + EV+TWG QLG+
Sbjct: 78 LGLGDVQSTIEPRRLDSLNGKKIACL----SYGSGPHIVLATTEGEVFTWGHNAYSQLGN 133
Query: 542 GDVLPRLQPLCVKC-LDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGH-SDFPTT 599
G L P + L K+VI + G YHSL LT+ +V++WG N GQ+G S
Sbjct: 134 GTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAWGYNNSGQVGSGSTVNQP 193
Query: 600 VPRLAKISSENG-VWSIAAGRDYSLFLVDTEDFQPGLYYSGRQDPTEGDNLPENHSGSK- 657
+PR +N V +IA G+ + +VDT + Y Q L +SG++
Sbjct: 194 IPRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNGNGQ-------LGLGNSGNQP 246
Query: 658 TPVLLSCSKLGYISRVTAGKDSYLALVDK 686
TP ++ + + RV G L L D+
Sbjct: 247 TPCRVAALQGIRVQRVACGYAHTLVLTDE 275
Score = 59.7 bits (143), Expect = 2e-08
Identities = 32/79 (40%), Positives = 44/79 (55%), Gaps = 5/79 (6%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSN 586
EV+ WG GQLG G+ + P V L G V + G H+L LT + QVY+WG+N
Sbjct: 225 EVYVWGYNGNGQLGLGNSGNQPTPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGAN 284
Query: 587 TFGQLG-----HSDFPTTV 600
++GQLG + +PT V
Sbjct: 285 SYGQLGTGNKSNQSYPTPV 303
Score = 56.2 bits (134), Expect = 3e-07
Identities = 46/169 (27%), Positives = 81/169 (47%), Gaps = 9/169 (5%)
Query: 518 DALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAG-GYHSLALTA 576
+ L ++ E++ G G LG GDV ++P + L+GK++ L G G H + T
Sbjct: 57 EVLYTTVNDEIFVLGTNCCGCLGLGDVQSTIEPRRLDSLNGKKIACLSYGSGPHIVLATT 116
Query: 577 KSQVYSWGSNTFGQLGH--SDFPTTVPRLAKISSENGVWSIAAGRDYSLFLV-DTEDFQP 633
+ +V++WG N + QLG+ ++ ++ S V +A G +SL L D E F
Sbjct: 117 EGEVFTWGHNAYSQLGNGTTNHGLVPCHISTNLSNKQVIEVACGSYHSLVLTSDGEVFAW 176
Query: 634 GLYYSGR--QDPTEGDNLPENHSG---SKTPVLLSCSKLGYISRVTAGK 677
G SG+ T +P +G +K V ++C ++ ++ V G+
Sbjct: 177 GYNNSGQVGSGSTVNQPIPRRVTGCLQNKVVVTIACGQMCCMAVVDTGE 225
Score = 51.6 bits (122), Expect = 6e-06
Identities = 46/151 (30%), Positives = 66/151 (43%), Gaps = 17/151 (11%)
Query: 32 PERLPGW-GGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPS----SPILEN 86
P R+ G K V+ A G + + + GEVY +G +G + + S +P
Sbjct: 195 PRRVTGCLQNKVVVTIACGQMCCMAVVDTGEVYVWGYNG--NGQLGLGNSGNQPTPCRVA 252
Query: 87 ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
AL G V VA G H+ +TD G Y WG NS GQ N+ P PV++
Sbjct: 253 ALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPVTVEKD---- 308
Query: 147 LLAVRILQL-ACGEEHTLALSI-SREIWAWG 175
RI+++ AC HT A ++ WG
Sbjct: 309 ----RIIEIAACHSTHTSAAKTQGGHVYMWG 335
Score = 45.8 bits (107), Expect = 3e-04
Identities = 45/167 (26%), Positives = 74/167 (44%), Gaps = 18/167 (10%)
Query: 13 GSKERGLVHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVY-----SFGT 67
G G + + +G+ P TP R+ G V + A G H ++LT++G+VY S+G
Sbjct: 230 GYNGNGQLGLGNSGNQP-TPCRVAALQGIRVQRVACGYAHTLVLTDEGQVYAWGANSYGQ 288
Query: 68 LPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVAN 127
L + + P+ +E + + I + S A T G YMWG+ GQ +
Sbjct: 289 LGTGNKSNQSYPTPVTVEKDRIIE--IAACHSTHTSAAKTQGGHVYMWGQ-CRGQSVI-- 343
Query: 128 QQYVPEPNPVSIADSE----ASPLLAVRILQLACGEEHTLALSISRE 170
+P S D A+P + R+L + + T+A S+ RE
Sbjct: 344 ---LPHLTHFSCTDDVFACFATPAVTWRLLSVEPDDHLTVAESLKRE 387
Score = 31.2 bits (69), Expect = 8.7
Identities = 22/72 (30%), Positives = 33/72 (45%), Gaps = 3/72 (4%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEA--GGYHSL 572
G A L+ + +V+ WG GQLG G+ + P V ++ +I + A + S
Sbjct: 265 GYAHTLVLTDEGQVYAWGANSYGQLGTGNKSNQSYPTPV-TVEKDRIIEIAACHSTHTSA 323
Query: 573 ALTAKSQVYSWG 584
A T VY WG
Sbjct: 324 AKTQGGHVYMWG 335
>gi|30039692 NIMA-related kinase 8 [Homo sapiens]
Length = 692
Score = 70.5 bits (171), Expect = 1e-11
Identities = 68/226 (30%), Positives = 99/226 (43%), Gaps = 24/226 (10%)
Query: 20 VHIWQAGSFPITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICP 79
V+ W G TP RLP + V+Q A G +T G + + P +G + P
Sbjct: 314 VYAWGGGLG--TPLRLPMLNTE-VVQVAAGRTQKAGVTRSGRLILWEAPPLGAGGGSLLP 370
Query: 80 SS------PILENALVGQYVIT---VATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQY 130
+ + L GQ +T VA G F + +TD G+ +G S G +
Sbjct: 371 GAVEQPQPQFISRFLEGQSGVTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGSLTD 430
Query: 131 VPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFP 188
+ +P V LL ++Q+ACG H LALS RE++AWG G +LGL T
Sbjct: 431 ISQPTIVEA-------LLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLGL-GTRES 482
Query: 189 VTKPQKVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKPVPERCNQ 234
+ PQ+V G+ +V CG S+ L +P Q L R N+
Sbjct: 483 HSCPQQVPMPPGQEAQRVVCGIDSSMILT--VPGQALACGSNRFNK 526
Score = 59.3 bits (142), Expect = 3e-08
Identities = 49/214 (22%), Positives = 94/214 (43%), Gaps = 25/214 (11%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVY---------------SFGTLPWRSGPVE 76
P+++P G+ + G+ ++LT G+ S G P VE
Sbjct: 486 PQQVPMPPGQEAQRVVCGIDSSMILTVPGQALACGSNRFNKLGLDHLSLGEEPVPHQQVE 545
Query: 77 ICPSSPILENALVGQY-VITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPN 135
S +L +A + Q ++++ G+ HS AVT +G Y +G N GQ ++
Sbjct: 546 EALSFTLLGSAPLDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLGTNTRRG----- 600
Query: 136 PVSIADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQ 193
S A + L +++ +ACG+ T+A+ E+++WG G +LG + +P
Sbjct: 601 --SRAPCKVQGLEGIKMAMVACGDAFTVAIGAESEVYSWGKGARGRLGRRDEDAGLPRPV 658
Query: 194 KVEHLAGRVVLQVACGAFHSLALVQCLPSQDLKP 227
+++ V V+C ++L V+ + + + P
Sbjct: 659 QLDETHPYTVTSVSCCHGNTLLAVRSVTDEPVPP 692
Score = 57.4 bits (137), Expect = 1e-07
Identities = 32/109 (29%), Positives = 55/109 (50%), Gaps = 1/109 (0%)
Query: 484 LPGLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGD 543
LPG + Q P+ + + ++ V + G+ + R + T+G G G LGHG
Sbjct: 369 LPGAVEQPQPQFISRFLEGQSG-VTIKHVACGDFFTACLTDRGIIMTFGSGSNGCLGHGS 427
Query: 544 VLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLG 592
+ QP V+ L G E++ + G H LAL+ + ++++WG G+LG
Sbjct: 428 LTDISQPTIVEALLGYEMVQVACGASHVLALSTERELFAWGRGDSGRLG 476
Score = 48.9 bits (115), Expect = 4e-05
Identities = 27/88 (30%), Positives = 45/88 (51%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLAL 574
G A + + + +T+G + GQLG P V+ L+G ++ + G ++A+
Sbjct: 569 GTAHSAAVTASGDCYTFGSNQHGQLGTNTRRGSRAPCKVQGLEGIKMAMVACGDAFTVAI 628
Query: 575 TAKSQVYSWGSNTFGQLGHSDFPTTVPR 602
A+S+VYSWG G+LG D +PR
Sbjct: 629 GAESEVYSWGKGARGRLGRRDEDAGLPR 656
Score = 42.7 bits (99), Expect = 0.003
Identities = 26/78 (33%), Positives = 36/78 (46%)
Query: 515 GEADALLPSLRTEVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLAL 574
G + L S E++ WG+G G+LG G P V G+E + G S+ L
Sbjct: 451 GASHVLALSTERELFAWGRGDSGRLGLGTRESHSCPQQVPMPPGQEAQRVVCGIDSSMIL 510
Query: 575 TAKSQVYSWGSNTFGQLG 592
T Q + GSN F +LG
Sbjct: 511 TVPGQALACGSNRFNKLG 528
Score = 36.6 bits (83), Expect = 0.21
Identities = 16/37 (43%), Positives = 24/37 (64%)
Query: 556 LDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLG 592
LD + ++ ++ G HS A+TA Y++GSN GQLG
Sbjct: 558 LDQEPLLSIDLGTAHSAAVTASGDCYTFGSNQHGQLG 594
>gi|239750800 PREDICTED: hypothetical protein XP_002347563 [Homo
sapiens]
Length = 596
Score = 68.2 bits (165), Expect = 6e-11
Identities = 38/112 (33%), Positives = 57/112 (50%), Gaps = 5/112 (4%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
VWTWGKG +LGH + +P V+ L GK+++H+ G H LA+ QVY+WG N
Sbjct: 77 VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 136
Query: 588 FGQLGHSDFPTTV---PRLAKISSENGVWSIAAGRDYSLFLVDTEDFQPGLY 636
GQ G+ TTV P L + + +A G +S+ + P ++
Sbjct: 137 HGQQGNG--TTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWTTVDVATPSVH 186
Score = 55.8 bits (133), Expect = 3e-07
Identities = 41/130 (31%), Positives = 65/130 (50%), Gaps = 10/130 (7%)
Query: 88 LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
L GQ V + G+ A+T +GV + WG+ + + +V +P V L
Sbjct: 53 LNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVE-------GL 105
Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQ 205
+I+ +A G +H LA+ S +++AWG Q G TT KP V+ L G+ ++
Sbjct: 106 RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVN-RKPTLVQGLEGQKIMC 164
Query: 206 VACGAFHSLA 215
VACG+ HS+A
Sbjct: 165 VACGSSHSVA 174
Score = 52.8 bits (125), Expect = 3e-06
Identities = 31/102 (30%), Positives = 52/102 (50%), Gaps = 1/102 (0%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
V++WG G G+LG G P ++ L+G+ V +E G LALT V++WG
Sbjct: 25 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 84
Query: 588 FGQLGH-SDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDT 628
+ +LGH SD P++ + + +A G + L ++D+
Sbjct: 85 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDS 126
Score = 52.4 bits (124), Expect = 4e-06
Identities = 38/138 (27%), Positives = 64/138 (46%), Gaps = 15/138 (10%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGT-----LPWRSGPVEICPSSPILEN 86
P+ + G+ V Q G + + LT+ G V+++G L RS ++ P +
Sbjct: 47 PQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRS---DVHVRKPQVVE 103
Query: 87 ALVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASP 146
L G+ ++ VA G+ H AV D+G Y WG+N GQ +P V + +
Sbjct: 104 GLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQ--- 160
Query: 147 LLAVRILQLACGEEHTLA 164
+I+ +ACG H++A
Sbjct: 161 ----KIMCVACGSSHSVA 174
Score = 50.8 bits (120), Expect = 1e-05
Identities = 31/108 (28%), Positives = 50/108 (46%), Gaps = 8/108 (7%)
Query: 111 VAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLALSISRE 170
+ + WG+ G+ + P + + + + Q+ CG + LAL+ S
Sbjct: 24 LVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG-------VCQIECGAQFLLALTKSGV 76
Query: 171 IWAWGTGCQLGL-ITTAFPVTKPQKVEHLAGRVVLQVACGAFHSLALV 217
+W WG G L + V KPQ VE L G+ ++ VA GA H LA++
Sbjct: 77 VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVM 124
Score = 37.7 bits (86), Expect = 0.093
Identities = 16/49 (32%), Positives = 28/49 (57%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALT 575
+V+ WG GQ G+G +P V+ L+G++++ + G HS+A T
Sbjct: 128 QVYAWGDNDHGQQGNGTTTVNRKPTLVQGLEGQKIMCVACGSSHSVAWT 176
Score = 31.2 bits (69), Expect = 8.7
Identities = 23/71 (32%), Positives = 31/71 (43%), Gaps = 16/71 (22%)
Query: 560 EVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHS-----DFPTTVPRLAKISSENGVWS 614
E+I + GY SL V+SWG FG+LG + P + RL + GV
Sbjct: 12 EIILSKLSGYESL-------VFSWGDGDFGKLGRGGSEGCNIPQNIERL----NGQGVCQ 60
Query: 615 IAAGRDYSLFL 625
I G + L L
Sbjct: 61 IECGAQFLLAL 71
>gi|239745140 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1052
Score = 67.8 bits (164), Expect = 8e-11
Identities = 37/99 (37%), Positives = 53/99 (53%), Gaps = 5/99 (5%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
VWTWGKG +LGH + +P V+ L GK+++H+ G H LA+ QVY+WG N
Sbjct: 729 VWTWGKGDYFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 788
Query: 588 FGQLGHSDFPTTV---PRLAKISSENGVWSIAAGRDYSL 623
GQ G+ TTV P L + + +A G +S+
Sbjct: 789 HGQQGNG--TTTVNRKPMLVQGLEGQKIMCVACGSSHSV 825
Score = 56.2 bits (134), Expect = 3e-07
Identities = 41/130 (31%), Positives = 65/130 (50%), Gaps = 10/130 (7%)
Query: 88 LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
L GQ V + G+ A+T +GV + WG+ + + +V +P V L
Sbjct: 705 LNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVE-------GL 757
Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQ 205
+I+ +A G +H LA+ S +++AWG Q G TT KP V+ L G+ ++
Sbjct: 758 RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVN-RKPMLVQGLEGQKIMC 816
Query: 206 VACGAFHSLA 215
VACG+ HS+A
Sbjct: 817 VACGSSHSVA 826
Score = 55.5 bits (132), Expect = 4e-07
Identities = 53/199 (26%), Positives = 81/199 (40%), Gaps = 30/199 (15%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVG- 90
P PG G + KHG L + G W PV + I+++ VG
Sbjct: 595 PADEPGPGAPAPQELGAAGKHGDLCEVSLTSSAQGEATWPH-PV-LFHFGEIIQDKSVGN 652
Query: 91 -QYVITVATGSFHSGAVTDN----------GVAYMWGENSAGQCAVANQQYVPEPNPVSI 139
+Y+ T G V+DN G+ + WG+ G+ + P +
Sbjct: 653 WEYIST--------GKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIER 704
Query: 140 ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGL-ITTAFPVTKPQKVEHL 198
+ + + Q+ CG + LAL+ S +W WG G L + V KPQ VE L
Sbjct: 705 LNGQG-------VCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKPQVVEGL 757
Query: 199 AGRVVLQVACGAFHSLALV 217
G+ ++ VA GA H LA++
Sbjct: 758 RGKKIVHVAVGAQHCLAVM 776
Score = 54.3 bits (129), Expect = 1e-06
Identities = 49/165 (29%), Positives = 70/165 (42%), Gaps = 31/165 (18%)
Query: 18 GLVHIWQAGSF-------------PITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64
GLV W G F P ERL G G V Q G + + LT+ G V++
Sbjct: 675 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG---VCQIECGAQFLLALTKSGVVWT 731
Query: 65 FGT-----LPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENS 119
+G L RS ++ P + L G+ ++ VA G+ H AV D+G Y WG+N
Sbjct: 732 WGKGDYFRLGHRS---DVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 788
Query: 120 AGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLA 164
GQ N P+ + E ++ V ACG H++A
Sbjct: 789 HGQ--QGNGTTTVNRKPMLVQGLEGQKIMCV-----ACGSSHSVA 826
Score = 52.8 bits (125), Expect = 3e-06
Identities = 31/102 (30%), Positives = 52/102 (50%), Gaps = 1/102 (0%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
V++WG G G+LG G P ++ L+G+ V +E G LALT V++WG
Sbjct: 677 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 736
Query: 588 FGQLGH-SDFPTTVPRLAKISSENGVWSIAAGRDYSLFLVDT 628
+ +LGH SD P++ + + +A G + L ++D+
Sbjct: 737 YFRLGHRSDVHVRKPQVVEGLRGKKIVHVAVGAQHCLAVMDS 778
Score = 38.9 bits (89), Expect = 0.042
Identities = 16/49 (32%), Positives = 29/49 (59%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALT 575
+V+ WG GQ G+G +P+ V+ L+G++++ + G HS+A T
Sbjct: 780 QVYAWGDNDHGQQGNGTTTVNRKPMLVQGLEGQKIMCVACGSSHSVAWT 828
>gi|21704281 junctophilin 2 isoform 1 [Homo sapiens]
Length = 696
Score = 67.8 bits (164), Expect = 8e-11
Identities = 48/164 (29%), Positives = 63/164 (38%), Gaps = 34/164 (20%)
Query: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEGK 1108
Y G W GK HG G+ P G+ GEY G W G
Sbjct: 14 YCGGWEGGKAHGHGLCTGPKGQ--------------GEYS-------------GSWNFGF 46
Query: 1109 MCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDD 1168
GVY++ SG FEG + RHG G+ G+ ++ G+W K YG+
Sbjct: 47 EVA-GVYTWPSGNTFEGYWSQGKRHGLGIETKGRW------LYKGEWTHGFKGRYGIRQS 99
Query: 1169 ITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGV 1212
+ G KY G W + + G G G Y+G F G GV
Sbjct: 100 SSSGAKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYGV 143
Score = 58.5 bits (140), Expect = 5e-08
Identities = 31/96 (32%), Positives = 49/96 (51%), Gaps = 11/96 (11%)
Query: 1048 TYDGRWLSGKPHGRGVL---KWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHW 1104
T++G W GK HG G+ +W +Y G + +G + YG ++ + Y G W
Sbjct: 59 TFEGYWSQGKRHGLGIETKGRW----LYKGEWTHGFKGRYGI----RQSSSSGAKYEGTW 110
Query: 1105 KEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS 1140
G G G +YA G ++G F + MRHG+G+ +S
Sbjct: 111 NNGLQDGYGTETYADGGTYQGQFTNGMRHGYGVRQS 146
Score = 41.6 bits (96), Expect = 0.006
Identities = 18/37 (48%), Positives = 24/37 (64%)
Query: 1100 YVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHG 1136
Y+G WK K G GV +SG +EG + DN+RHG+G
Sbjct: 291 YMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYG 327
Score = 40.8 bits (94), Expect = 0.011
Identities = 17/39 (43%), Positives = 21/39 (53%)
Query: 1047 ATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYG 1085
A Y+G W +G G G + DG Y G F NG+ GYG
Sbjct: 104 AKYEGTWNNGLQDGYGTETYADGGTYQGQFTNGMRHGYG 142
Score = 39.3 bits (90), Expect = 0.032
Identities = 18/66 (27%), Positives = 36/66 (54%), Gaps = 1/66 (1%)
Query: 1143 LTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNF 1202
+ +++ ++G+W DK++G+GV + + G +Y G W D++ G G G EG +
Sbjct: 283 IDATTTETYMGEWKNDKRSGFGV-SERSSGLRYEGEWLDNLRHGYGCTTLPDGHREEGKY 341
Query: 1203 HLNKMM 1208
N ++
Sbjct: 342 RHNVLV 347
Score = 38.5 bits (88), Expect = 0.055
Identities = 24/68 (35%), Positives = 31/68 (45%)
Query: 1158 DKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSED 1217
D+ A + D T E YMG W++D G GV GL YEG + N G G D
Sbjct: 274 DEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLDNLRHGYGCTTLPD 333
Query: 1218 DTIYEGEF 1225
EG++
Sbjct: 334 GHREEGKY 341
Score = 33.9 bits (76), Expect = 1.3
Identities = 26/112 (23%), Positives = 41/112 (36%), Gaps = 3/112 (2%)
Query: 999 AISQAVDQALRGMSDLPPYGSGSSVQRQEPPISR---SAKYTFYKDPRLKDATYDGRWLS 1055
A + ++ +A G + P+ + E + + F R Y+G WL
Sbjct: 261 ASTASLGEAAEGADEAAPFEADIDATTTETYMGEWKNDKRSGFGVSERSSGLRYEGEWLD 320
Query: 1056 GKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEG 1107
HG G PDG G +R+ + + R+ NK V H EG
Sbjct: 321 NLRHGYGCTTLPDGHREEGKYRHNVLVKDTKRRMLQLKSNKVRQKVEHSVEG 372
Score = 33.5 bits (75), Expect = 1.8
Identities = 31/136 (22%), Positives = 51/136 (37%), Gaps = 9/136 (6%)
Query: 1138 LRSGKLTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLY 1197
+ G+ + G W K G+G+ +Y G W + GV G
Sbjct: 1 MSGGRFDFDDGGAYCGGWEGGKAHGHGLCTGPKGQGEYSGSWNFGF-EVAGVYTWPSGNT 59
Query: 1198 YEGNFHLNKMMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGI 1257
+EG + K G G+ ++ +Y+GE WT KG + + G W +G+
Sbjct: 60 FEGYWSQGKRHGLGIE-TKGRWLYKGE----WTHGFKGRYGIRQSSSSGAKYEGTWNNGL 114
Query: 1258 KI---TGTYFKPSLYE 1270
+ T TY Y+
Sbjct: 115 QDGYGTETYADGGTYQ 130
>gi|21704283 junctophilin 3 [Homo sapiens]
Length = 748
Score = 67.4 bits (163), Expect = 1e-10
Identities = 49/165 (29%), Positives = 64/165 (38%), Gaps = 34/165 (20%)
Query: 1048 TYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEG 1107
+Y G W GK HG GV P G+ GEY G W G
Sbjct: 14 SYCGGWEDGKAHGHGVCTGPKGQ--------------GEY-------------TGSWSHG 46
Query: 1108 KMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFD 1167
GVY++ SG ++G + RHG GL GK ++ G+W K YGV +
Sbjct: 47 FEV-LGVYTWPSGNTYQGTWAQGKRHGIGLESKGKW------VYKGEWTHGFKGRYGVRE 99
Query: 1168 DITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGV 1212
G KY G W + + G G G Y+G + G GV
Sbjct: 100 CAGNGAKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGV 144
Score = 52.0 bits (123), Expect = 5e-06
Identities = 30/96 (31%), Positives = 43/96 (44%), Gaps = 11/96 (11%)
Query: 1048 TYDGRWLSGKPHGRGVL---KWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHW 1104
TY G W GK HG G+ KW +Y G + +G + YG Y G W
Sbjct: 60 TYQGTWAQGKRHGIGLESKGKW----VYKGEWTHGFKGRYGVRECAGNGAK----YEGTW 111
Query: 1105 KEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLLRS 1140
G G G +Y+ G ++G + MR G+G+ +S
Sbjct: 112 SNGLQDGYGTETYSDGGTYQGQWVGGMRQGYGVRQS 147
Score = 45.8 bits (107), Expect = 3e-04
Identities = 25/73 (34%), Positives = 36/73 (49%)
Query: 1168 DITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNFHLNKMMGNGVLLSEDDTIYEGEFSD 1227
D T E Y+G W++D G GV GL YEG + N+ G G + D T EG++
Sbjct: 281 DATTTETYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKYKQ 340
Query: 1228 DWTLSGKGTLTMP 1240
+ + GK +P
Sbjct: 341 NILVGGKRKNLIP 353
Score = 41.6 bits (96), Expect = 0.006
Identities = 39/159 (24%), Positives = 62/159 (38%), Gaps = 29/159 (18%)
Query: 1109 MCGQGVYSYASGEVFEGCFQDNMRHGHGLLRSGKLTSSSPSMFIGQWVMDKKAGYGVFDD 1168
M G +++ G + G ++D HGHG+ K + G W G+ V
Sbjct: 1 MSSGGRFNFDDGGSYCGGWEDGKAHGHGVCTGPK----GQGEYTGSW----SHGFEVLGV 52
Query: 1169 IT--RGEKYMGMWQDDVCQGNGVVVTQFGLY-------YEGNFHLNKMMGNGVLLSEDDT 1219
T G Y G W G G+ +Y ++G + + + GNG
Sbjct: 53 YTWPSGNTYQGTWAQGKRHGIGLESKGKWVYKGEWTHGFKGRYGVRECAGNGAK------ 106
Query: 1220 IYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIK 1258
YEG +S+ G GT T +G G + G+W G++
Sbjct: 107 -YEGTWSNG-LQDGYGTETYSDG----GTYQGQWVGGMR 139
Score = 39.3 bits (90), Expect = 0.032
Identities = 19/67 (28%), Positives = 35/67 (52%), Gaps = 1/67 (1%)
Query: 1143 LTSSSPSMFIGQWVMDKKAGYGVFDDITRGEKYMGMWQDDVCQGNGVVVTQFGLYYEGNF 1202
+ +++ ++G+W DK++G+GV + G KY G W + G G + G EG +
Sbjct: 280 IDATTTETYVGEWKNDKRSGFGV-SQRSDGLKYEGEWASNRRHGYGCMTFPDGTKEEGKY 338
Query: 1203 HLNKMMG 1209
N ++G
Sbjct: 339 KQNILVG 345
Score = 38.9 bits (89), Expect = 0.042
Identities = 17/39 (43%), Positives = 22/39 (56%)
Query: 1100 YVGHWKEGKMCGQGVYSYASGEVFEGCFQDNMRHGHGLL 1138
YVG WK K G GV + G +EG + N RHG+G +
Sbjct: 288 YVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCM 326
Score = 36.6 bits (83), Expect = 0.21
Identities = 15/39 (38%), Positives = 20/39 (51%)
Query: 1047 ATYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYG 1085
A Y+G W +G G G + DG Y G + G+ GYG
Sbjct: 105 AKYEGTWSNGLQDGYGTETYSDGGTYQGQWVGGMRQGYG 143
Score = 34.3 bits (77), Expect = 1.0
Identities = 17/46 (36%), Positives = 25/46 (54%), Gaps = 1/46 (2%)
Query: 1049 YDGRWLSGKPHGRGVLKWPDGKMYSGMFR-NGLEDGYGEYRIPNKA 1093
Y+G W S + HG G + +PDG G ++ N L G + IP +A
Sbjct: 311 YEGEWASNRRHGYGCMTFPDGTKEEGKYKQNILVGGKRKNLIPLRA 356
Score = 33.1 bits (74), Expect = 2.3
Identities = 21/64 (32%), Positives = 30/64 (46%), Gaps = 5/64 (7%)
Query: 1048 TYDGRWLSGKPHGRGVLKWPDGKMYSGMFRNGLEDGYGEYRIPNKAMNKEDHYVGHWKEG 1107
TY G W + K G GV + DG Y G + + GYG P+ KE+ G +K+
Sbjct: 287 TYVGEWKNDKRSGFGVSQRSDGLKYEGEWASNRRHGYGCMTFPDG--TKEE---GKYKQN 341
Query: 1108 KMCG 1111
+ G
Sbjct: 342 ILVG 345
Score = 31.2 bits (69), Expect = 8.7
Identities = 19/61 (31%), Positives = 27/61 (44%), Gaps = 4/61 (6%)
Query: 1207 MMGNGVLLSEDDTIYEGEFSDDWTLSGKGTLTMPNGDYIEGYFSGEWGSGIKITGTYFKP 1266
M G +D Y G + +D G G T P G +G ++G W G ++ G Y P
Sbjct: 1 MSSGGRFNFDDGGSYCGGW-EDGKAHGHGVCTGPKG---QGEYTGSWSHGFEVLGVYTWP 56
Query: 1267 S 1267
S
Sbjct: 57 S 57
>gi|63054860 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 66.2 bits (160), Expect = 2e-10
Identities = 39/111 (35%), Positives = 58/111 (52%), Gaps = 8/111 (7%)
Query: 484 LPGLLSQVSPRL---LRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 540
LP + VSPR A ++ R + L G ALL +V++WG G+ GQLG
Sbjct: 137 LPCARAYVSPRAPFYRPLAPELRARQLEL-----GAEHALLLDAAGQVFSWGGGRHGQLG 191
Query: 541 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQL 591
HG + L+P ++ L G + + AGG+HS+ ++ +Y WG N GQL
Sbjct: 192 HGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQL 242
Score = 64.3 bits (155), Expect = 9e-10
Identities = 55/207 (26%), Positives = 90/207 (43%), Gaps = 40/207 (19%)
Query: 45 QAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSF 101
Q LG +H +LL G+V+S+G G +E P L AL G + VA G +
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLE-AELEPRLLEALQGLVMAEVAAGGW 220
Query: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS------------------IADSE 143
HS V++ G Y+WG N +GQ A+ + + V+ D
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
Query: 144 ASPLLAVR-------------ILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFP 188
+P +AV+ ++ +CG HT ++ + E+ W WG QLG T
Sbjct: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT-S 339
Query: 189 VTKPQKVEHLAGR--VVLQVACGAFHS 213
+ +P++VE+ + V V CG +++
Sbjct: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366
Score = 45.1 bits (105), Expect = 6e-04
Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 564 LEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV-PRLAKISSENGVWSIAAGRDYS 622
LE G H+L L A QV+SWG GQLGH + PRL + + +AAG +S
Sbjct: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
Query: 623 LFLVDTED 630
+ + +T D
Sbjct: 223 VCVSETGD 230
Score = 41.2 bits (95), Expect = 0.008
Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 150 VRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVA 207
+R QL G EH L L + ++++WG G QLG T + +P+ +E L G V+ +VA
Sbjct: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVA 216
Query: 208 CGAFHSLAL 216
G +HS+ +
Sbjct: 217 AGGWHSVCV 225
Score = 38.1 bits (87), Expect = 0.071
Identities = 13/38 (34%), Positives = 21/38 (55%)
Query: 558 GKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD 595
G + + G H+ +T ++Y+WG +GQLGH D
Sbjct: 299 GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHED 336
Score = 32.0 bits (71), Expect = 5.1
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEV 561
E++TWG GK GQLGH D +P V+ K++
Sbjct: 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL 354
>gi|63054858 RCC1 domain containing 1 [Homo sapiens]
Length = 376
Score = 66.2 bits (160), Expect = 2e-10
Identities = 39/111 (35%), Positives = 58/111 (52%), Gaps = 8/111 (7%)
Query: 484 LPGLLSQVSPRL---LRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLG 540
LP + VSPR A ++ R + L G ALL +V++WG G+ GQLG
Sbjct: 137 LPCARAYVSPRAPFYRPLAPELRARQLEL-----GAEHALLLDAAGQVFSWGGGRHGQLG 191
Query: 541 HGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQL 591
HG + L+P ++ L G + + AGG+HS+ ++ +Y WG N GQL
Sbjct: 192 HGTLEAELEPRLLEALQGLVMAEVAAGGWHSVCVSETGDIYIWGWNESGQL 242
Score = 64.3 bits (155), Expect = 9e-10
Identities = 55/207 (26%), Positives = 90/207 (43%), Gaps = 40/207 (19%)
Query: 45 QAALGVKHGVLLTEDGEVYSFGTLPWRS---GPVEICPSSPILENALVGQYVITVATGSF 101
Q LG +H +LL G+V+S+G G +E P L AL G + VA G +
Sbjct: 162 QLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLE-AELEPRLLEALQGLVMAEVAAGGW 220
Query: 102 HSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVS------------------IADSE 143
HS V++ G Y+WG N +GQ A+ + + V+ D
Sbjct: 221 HSVCVSETGDIYIWGWNESGQLALPTRNLAEDGETVAREATELNEDGSQVKRTGGAEDGA 280
Query: 144 ASPLLAVR-------------ILQLACGEEHTLALSISREI--WAWGTGCQLGLITTAFP 188
+P +AV+ ++ +CG HT ++ + E+ W WG QLG T
Sbjct: 281 PAPFIAVQPFPALLDLPMGSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHEDTT-S 339
Query: 189 VTKPQKVEHLAGR--VVLQVACGAFHS 213
+ +P++VE+ + V V CG +++
Sbjct: 340 LDRPRRVEYFVDKQLQVKAVTCGPWNT 366
Score = 45.1 bits (105), Expect = 6e-04
Identities = 26/68 (38%), Positives = 36/68 (52%), Gaps = 1/68 (1%)
Query: 564 LEAGGYHSLALTAKSQVYSWGSNTFGQLGHSDFPTTV-PRLAKISSENGVWSIAAGRDYS 622
LE G H+L L A QV+SWG GQLGH + PRL + + +AAG +S
Sbjct: 163 LELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAELEPRLLEALQGLVMAEVAAGGWHS 222
Query: 623 LFLVDTED 630
+ + +T D
Sbjct: 223 VCVSETGD 230
Score = 41.2 bits (95), Expect = 0.008
Identities = 25/69 (36%), Positives = 40/69 (57%), Gaps = 3/69 (4%)
Query: 150 VRILQLACGEEHTLALSISREIWAWGTG--CQLGLITTAFPVTKPQKVEHLAGRVVLQVA 207
+R QL G EH L L + ++++WG G QLG T + +P+ +E L G V+ +VA
Sbjct: 158 LRARQLELGAEHALLLDAAGQVFSWGGGRHGQLGHGTLEAEL-EPRLLEALQGLVMAEVA 216
Query: 208 CGAFHSLAL 216
G +HS+ +
Sbjct: 217 AGGWHSVCV 225
Score = 38.1 bits (87), Expect = 0.071
Identities = 13/38 (34%), Positives = 21/38 (55%)
Query: 558 GKEVIHLEAGGYHSLALTAKSQVYSWGSNTFGQLGHSD 595
G + + G H+ +T ++Y+WG +GQLGH D
Sbjct: 299 GSDAVKASCGSRHTAVVTRTGELYTWGWGKYGQLGHED 336
Score = 32.0 bits (71), Expect = 5.1
Identities = 15/35 (42%), Positives = 21/35 (60%)
Query: 527 EVWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEV 561
E++TWG GK GQLGH D +P V+ K++
Sbjct: 320 ELYTWGWGKYGQLGHEDTTSLDRPRRVEYFVDKQL 354
>gi|239756261 PREDICTED: similar to hect domain and RLD 2 [Homo
sapiens]
Length = 1102
Score = 63.9 bits (154), Expect = 1e-09
Identities = 36/99 (36%), Positives = 52/99 (52%), Gaps = 5/99 (5%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
VWTWGKG +LGH + + V+ L GK+++H+ G H LA+ QVY+WG N
Sbjct: 779 VWTWGKGDYFRLGHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 838
Query: 588 FGQLGHSDFPTTV---PRLAKISSENGVWSIAAGRDYSL 623
GQ G+ TTV P L + + +A G +S+
Sbjct: 839 HGQQGNG--TTTVNRKPMLVQGLEGQKIMCVACGSSHSV 875
Score = 52.4 bits (124), Expect = 4e-06
Identities = 40/130 (30%), Positives = 64/130 (49%), Gaps = 10/130 (7%)
Query: 88 LVGQYVITVATGSFHSGAVTDNGVAYMWGENSAGQCAVANQQYVPEPNPVSIADSEASPL 147
L GQ V + G+ A+T +GV + WG+ + + +V + V L
Sbjct: 755 LNGQGVCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVE-------GL 807
Query: 148 LAVRILQLACGEEHTLALSISREIWAWGTGC--QLGLITTAFPVTKPQKVEHLAGRVVLQ 205
+I+ +A G +H LA+ S +++AWG Q G TT KP V+ L G+ ++
Sbjct: 808 RGKKIVHVAVGAQHCLAVMDSGQVYAWGDNDHGQQGNGTTTVN-RKPMLVQGLEGQKIMC 866
Query: 206 VACGAFHSLA 215
VACG+ HS+A
Sbjct: 867 VACGSSHSVA 876
Score = 51.6 bits (122), Expect = 6e-06
Identities = 52/199 (26%), Positives = 80/199 (40%), Gaps = 30/199 (15%)
Query: 32 PERLPGWGGKTVLQAALGVKHGVLLTEDGEVYSFGTLPWRSGPVEICPSSPILENALVG- 90
P PG G + KHG L + G W PV + I+++ VG
Sbjct: 645 PADEPGPGAPAPQELGAAGKHGDLCEVSLTSSAQGEATWPH-PV-LFHFGEIIQDKSVGN 702
Query: 91 -QYVITVATGSFHSGAVTDN----------GVAYMWGENSAGQCAVANQQYVPEPNPVSI 139
+Y+ T G V+DN G+ + WG+ G+ + P +
Sbjct: 703 WEYIST--------GKVSDNYALLTKCEMGGLVFSWGDGDFGKLGRGGSEGCNIPQNIER 754
Query: 140 ADSEASPLLAVRILQLACGEEHTLALSISREIWAWGTGCQLGL-ITTAFPVTKPQKVEHL 198
+ + + Q+ CG + LAL+ S +W WG G L + V K Q VE L
Sbjct: 755 LNGQG-------VCQIECGAQFLLALTKSGVVWTWGKGDYFRLGHRSDVHVRKLQVVEGL 807
Query: 199 AGRVVLQVACGAFHSLALV 217
G+ ++ VA GA H LA++
Sbjct: 808 RGKKIVHVAVGAQHCLAVM 826
Score = 50.4 bits (119), Expect = 1e-05
Identities = 48/165 (29%), Positives = 69/165 (41%), Gaps = 31/165 (18%)
Query: 18 GLVHIWQAGSF-------------PITPERLPGWGGKTVLQAALGVKHGVLLTEDGEVYS 64
GLV W G F P ERL G G V Q G + + LT+ G V++
Sbjct: 725 GLVFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQG---VCQIECGAQFLLALTKSGVVWT 781
Query: 65 FGT-----LPWRSGPVEICPSSPILENALVGQYVITVATGSFHSGAVTDNGVAYMWGENS 119
+G L RS ++ + L G+ ++ VA G+ H AV D+G Y WG+N
Sbjct: 782 WGKGDYFRLGHRS---DVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDSGQVYAWGDND 838
Query: 120 AGQCAVANQQYVPEPNPVSIADSEASPLLAVRILQLACGEEHTLA 164
GQ N P+ + E ++ V ACG H++A
Sbjct: 839 HGQ--QGNGTTTVNRKPMLVQGLEGQKIMCV-----ACGSSHSVA 876
Score = 49.3 bits (116), Expect = 3e-05
Identities = 31/103 (30%), Positives = 51/103 (49%), Gaps = 3/103 (2%)
Query: 528 VWTWGKGKEGQLGHGDVLPRLQPLCVKCLDGKEVIHLEAGGYHSLALTAKSQVYSWGSNT 587
V++WG G G+LG G P ++ L+G+ V +E G LALT V++WG
Sbjct: 727 VFSWGDGDFGKLGRGGSEGCNIPQNIERLNGQGVCQIECGAQFLLALTKSGVVWTWGKGD 786
Query: 588 FGQLGHSDFPTTVPRLAKISSENG--VWSIAAGRDYSLFLVDT 628
+ +LGH V +L + G + +A G + L ++D+
Sbjct: 787 YFRLGHRS-DVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDS 828
Score = 39.3 bits (90), Expect = 0.032
Identities = 24/90 (26%), Positives = 45/90 (50%), Gaps = 2/90 (2%)
Query: 486 GLLSQVSPRLLRKAARVKTRTVVLTPTYSGEADALLPSLRTEVWTWGKGKEGQLGHGDVL 545
G S V R L+ ++ + +V + A++ S +V+ WG GQ G+G
Sbjct: 791 GHRSDVHVRKLQVVEGLRGKKIVHVAVGAQHCLAVMDS--GQVYAWGDNDHGQQGNGTTT 848
Query: 546 PRLQPLCVKCLDGKEVIHLEAGGYHSLALT 575
+P+ V+ L+G++++ + G HS+A T
Sbjct: 849 VNRKPMLVQGLEGQKIMCVACGSSHSVAWT 878
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.133 0.400
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 65,233,680
Number of Sequences: 37866
Number of extensions: 3124515
Number of successful extensions: 9697
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 48
Number of HSP's that attempted gapping in prelim test: 8585
Number of HSP's gapped (non-prelim): 584
length of query: 1657
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1541
effective length of database: 13,855,062
effective search space: 21350650542
effective search space used: 21350650542
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.