Search of human proteins with 38327037

Search of human proteins with 38327037

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|38327037 hyperpolarization activated cyclic nucleotide-gated
potassium channel 3 [Homo sapiens]
         (774 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|38327037 hyperpolarization activated cyclic nucleotide-gated ...  1560   0.0  
gi|4885407 hyperpolarization activated cyclic nucleotide-gated p...   962   0.0  
gi|156071470 hyperpolarization activated cyclic nucleotide-gated...   909   0.0  
gi|116325989 hyperpolarization activated cyclic nucleotide-gated...   883   0.0  
gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Ho...   183   6e-46
gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2 [...   181   3e-45
gi|13540549 potassium voltage-gated channel, subfamily H, member...   174   3e-43
gi|26051273 voltage-gated potassium channel, subfamily H, member...   172   1e-42
gi|4557729 voltage-gated potassium channel, subfamily H, member ...   171   2e-42
gi|6912446 potassium voltage-gated channel, subfamily H, member ...   167   4e-41
gi|4504831 potassium voltage-gated channel, subfamily H, member ...   164   2e-40
gi|22024390 potassium voltage-gated channel, subfamily H, member...   164   3e-40
gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]    164   3e-40
gi|27886648 potassium voltage-gated channel, subfamily H, member...   164   4e-40
gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]    163   5e-40
gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1 [...   163   6e-40
gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [H...   163   6e-40
gi|27886651 potassium voltage-gated channel, subfamily H, member...   162   8e-40
gi|27437001 potassium voltage-gated channel, subfamily H, member...   158   2e-38
gi|27886653 potassium voltage-gated channel, subfamily H, member...   157   5e-38
gi|26051271 voltage-gated potassium channel, subfamily H, member...   154   3e-37
gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [H...   151   3e-36
gi|27886646 potassium voltage-gated channel, subfamily H, member...   149   1e-35
gi|27886667 potassium voltage-gated channel, subfamily H, member...   143   5e-34
gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]    135   1e-31
gi|38569493 potassium voltage-gated channel, subfamily H (eag-re...   134   2e-31
gi|27886665 potassium voltage-gated channel, subfamily H, member...   119   8e-27
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]     54   7e-07
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    53   1e-06
gi|112734870 hypothetical protein LOC57648 [Homo sapiens]              51   5e-06

>gi|38327037 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 3 [Homo sapiens]
          Length = 774

 Score = 1560 bits (4038), Expect = 0.0
 Identities = 774/774 (100%), Positives = 774/774 (100%)

Query: 1   MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKF 60
           MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKF
Sbjct: 1   MEAEQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKF 60

Query: 61  SLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE 120
           SLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE
Sbjct: 61  SLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE 120

Query: 121 ENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISS 180
           ENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISS
Sbjct: 121 ENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISS 180

Query: 181 IPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHM 240
           IPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHM
Sbjct: 181 IPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHM 240

Query: 241 TYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH 300
           TYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH
Sbjct: 241 TYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH 300

Query: 301 ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQY 360
           ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQY
Sbjct: 301 ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQY 360

Query: 361 QEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCR 420
           QEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCR
Sbjct: 361 QEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCR 420

Query: 421 GLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGA 480
           GLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGA
Sbjct: 421 GLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGA 480

Query: 481 RDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVA 540
           RDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVA
Sbjct: 481 RDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVA 540

Query: 541 MDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKP 600
           MDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKP
Sbjct: 541 MDRLLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKP 600

Query: 601 VLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPV 660
           VLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPV
Sbjct: 601 VLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPV 660

Query: 661 RAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLP 720
           RAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLP
Sbjct: 661 RAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLP 720

Query: 721 QRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM 774
           QRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM
Sbjct: 721 QRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATPRGLQLSANM 774


>gi|4885407 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 4 [Homo sapiens]
          Length = 1203

 Score =  962 bits (2487), Expect = 0.0
 Identities = 520/814 (63%), Positives = 592/814 (72%), Gaps = 61/814 (7%)

Query: 4   EQRPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPK------------------ 45
           ++ P   A+E   PG  A P  +PPP      P   S  +P                   
Sbjct: 142 DRTPPGLAAEPERPGASAQPAASPPPPQQPPQPASASCEQPSVDTAIKVEGGAAAGDQIL 201

Query: 46  -------------RRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDF 92
                        +R  G +LQP VNKFSLR+FGS KAVE EQERVKSAG WIIHPYSDF
Sbjct: 202 PEAEVRLGQAGFMQRQFGAMLQPGVNKFSLRMFGSQKAVEREQERVKSAGFWIIHPYSDF 261

Query: 93  RFYWDLIMLLLMVGNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVE 152
           RFYWDL MLLLMVGNLI++PVGITFFK+EN+ PWIVFNV+SDTFFL+DLVLNFRTGIVVE
Sbjct: 262 RFYWDLTMLLLMVGNLIIIPVGITFFKDENTTPWIVFNVVSDTFFLIDLVLNFRTGIVVE 321

Query: 153 EGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRF 212
           +  EI+L P+ I+ +YL++WF+VD ISSIPVDYIFL+VE   R+D+EVYKTARALRIVRF
Sbjct: 322 DNTEIILDPQRIKMKYLKSWFMVDFISSIPVDYIFLIVET--RIDSEVYKTARALRIVRF 379

Query: 213 TKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLV 272
           TKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI NLIGMMLLLCHWDGCLQFLV
Sbjct: 380 TKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIVNLIGMMLLLCHWDGCLQFLV 439

Query: 273 PMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSM 332
           PMLQDFP DCWVSIN+MVN+SWG+QYS+ALFKAMSHMLCIGYG+QAPVGM DVWLTMLSM
Sbjct: 440 PMLQDFPDDCWVSINNMVNNSWGKQYSYALFKAMSHMLCIGYGRQAPVGMSDVWLTMLSM 499

Query: 333 IVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY 392
           IVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLP DTRQRIH+YYEHRY
Sbjct: 500 IVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPPDTRQRIHDYYEHRY 559

Query: 393 QGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPG 452
           QGKMFDEESILGELSEPLREEIINF CR LVA MPLFA+ADP+FVT++LTKLRFEVFQPG
Sbjct: 560 QGKMFDEESILGELSEPLREEIINFNCRKLVASMPLFANADPNFVTSMLTKLRFEVFQPG 619

Query: 453 DLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYC 512
           D ++REG++G+KMYFIQHG++SVL +G ++T+L DGSYFGEICLLTRGRRTASVRADTYC
Sbjct: 620 DYIIREGTIGKKMYFIQHGVVSVLTKGNKETKLADGSYFGEICLLTRGRRTASVRADTYC 679

Query: 513 RLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSEPSPGSSGGIME- 571
           RLYSLSVD+FN VLEE+PMMRRAFETVA+DRL RIGKKNSIL  K             E 
Sbjct: 680 RLYSLSVDNFNEVLEEYPMMRRAFETVALDRLDRIGKKNSILLHKVQHDLNSGVFNYQEN 739

Query: 572 ---QHLVQHDRDMARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQ- 627
              Q +VQHDR+MA        +  A  +  PV+W PL+ APLQAAA T++VAIALTH  
Sbjct: 740 EIIQQIVQHDREMAHCAHRVQAAASATPTPTPVIWTPLIQAPLQAAAATTSVAIALTHHP 799

Query: 628 RGPLPLSPDSPATLLARSAWRSAGSPASP--------LVPVRAG---PWASTSRLPAPPA 676
           R P  +    P + L      + G+  +P        L+P   G   P +S S++  P +
Sbjct: 800 RLPAAIFRPPPGSGLG-----NLGAGQTPRHLKRLQSLIPSALGSASPASSPSQVDTPSS 854

Query: 677 RTLHASLSRAGRSQVSLLGP--PPGGGGRRLGPRGRPLSASQPSLPQRAT---GDGSPGR 731
            + H     AG S  + L P  P        G  G P SA  PS    AT   G G   +
Sbjct: 855 SSFHIQ-QLAGFSAPAGLSPLLPSSSSSPPPGACGSP-SAPTPSAGVAATTIAGFGHFHK 912

Query: 732 KGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATP 765
              GS     S LL      A+ P+   P PA P
Sbjct: 913 ALGGSLSSSDSPLLTPLQPGARSPQAAQPSPAPP 946



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 48/153 (31%), Positives = 54/153 (35%), Gaps = 32/153 (20%)

Query: 629  GPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGR 688
            GPL      P      S    A   ASP+     G  +     P PP RT  ++  RA  
Sbjct: 989  GPLSTPETPPRQPEPPSLVAGASGGASPVGFTPRGGLSPPGHSPGPP-RTFPSAPPRASG 1047

Query: 689  SQVSLL------GPPPGGGGRRLGPRGRP---------LSASQPSLPQ------RATGDG 727
            S  SLL       PPP    RR  P   P         +SASQP+LPQ      R     
Sbjct: 1048 SHGSLLLPPASSPPPPQVPQRRGTPPLTPGRLTQDLKLISASQPALPQDGAQTLRRASPH 1107

Query: 728  SPG----------RKGSGSERLPPSGLLAKPPR 750
            S G          R G GS     SG L  P R
Sbjct: 1108 SSGESMAAFPLFPRAGGGSGGSGSSGGLGPPGR 1140



 Score = 33.5 bits (75), Expect = 0.77
 Identities = 31/86 (36%), Positives = 37/86 (43%), Gaps = 10/86 (11%)

Query: 685 RAGRSQVSLLGPPPGG-GGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSG 743
           R  R  ++ LG   GG GG   G     L  S       A GD SPG      +R PP G
Sbjct: 94  RRFRGSLASLGSRGGGSGGTGSGSSHGHLHDSAEERRLIAEGDASPGE-----DRTPP-G 147

Query: 744 LLAKPPR---TAQPPRPPVPEPATPR 766
           L A+P R   +AQP   P P    P+
Sbjct: 148 LAAEPERPGASAQPAASPPPPQQPPQ 173


>gi|156071470 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 2 [Homo sapiens]
          Length = 889

 Score =  909 bits (2348), Expect = 0.0
 Identities = 498/774 (64%), Positives = 567/774 (73%), Gaps = 51/774 (6%)

Query: 10  GASEGATPGLEAVPPVAPPPATAASGPIPKSGPEPK-------RRHLGTLLQPTVNKFSL 62
           GA+ G  PG        P PA  A         EP+       +R  G LLQP VNKFSL
Sbjct: 129 GAASGPAPG--------PGPAEEAGSEEAGPAGEPRGSQASFMQRQFGALLQPGVNKFSL 180

Query: 63  RVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEEN 122
           R+FGS KAVE EQERVKSAGAWIIHPYSDFRFYWD  MLL MVGNLI++PVGITFFK+E 
Sbjct: 181 RMFGSQKAVEREQERVKSAGAWIIHPYSDFRFYWDFTMLLFMVGNLIIIPVGITFFKDET 240

Query: 123 SPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIP 182
           + PWIVFNV+SDTFFL+DLVLNFRTGIV+E+  EI+L P  I+ +YLRTWF+VD +SSIP
Sbjct: 241 TAPWIVFNVVSDTFFLMDLVLNFRTGIVIEDNTEIILDPEKIKKKYLRTWFVVDFVSSIP 300

Query: 183 VDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY 242
           VDYIFL+VE    +D+EVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY
Sbjct: 301 VDYIFLIVE--KGIDSEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTY 358

Query: 243 DLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHAL 302
           DLASAV+RI NLI MMLLLCHWDGCLQFLVPMLQDFP +CWVSIN MVNHSW   YS AL
Sbjct: 359 DLASAVMRICNLISMMLLLCHWDGCLQFLVPMLQDFPRNCWVSINGMVNHSWSELYSFAL 418

Query: 303 FKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 362
           FKAMSHMLCIGYG+QAP  M D+WLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE
Sbjct: 419 FKAMSHMLCIGYGRQAPESMTDIWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 478

Query: 363 KYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGELSEPLREEIINFTCRGL 422
           KYKQVEQYMSFHKLPAD RQ+IH+YYEHRYQGKMFDE+SILGEL+ PLREEI+NF CR L
Sbjct: 479 KYKQVEQYMSFHKLPADFRQKIHDYYEHRYQGKMFDEDSILGELNGPLREEIVNFNCRKL 538

Query: 423 VAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARD 482
           VA MPLFA+ADP+FVTA+LTKL+FEVFQPGD ++REG++G+KMYFIQHG++SVL +G ++
Sbjct: 539 VASMPLFANADPNFVTAMLTKLKFEVFQPGDYIIREGTIGKKMYFIQHGVVSVLTKGNKE 598

Query: 483 TRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMD 542
            +L+DGSYFGEICLLTRGRRTASVRADTYCRLYSLSVD+FN VLEE+PMMRRAFETVA+D
Sbjct: 599 MKLSDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDNFNEVLEEYPMMRRAFETVAID 658

Query: 543 RLLRIGKKNSILQRK-RSEPSPG---SSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSG 598
           RL RIGKKNSIL  K + + + G   +    + Q +V++DR+M +          A+L  
Sbjct: 659 RLDRIGKKNSILLHKVQHDLNSGVFNNQENAIIQEIVKYDREMVQ---------QAELGQ 709

Query: 599 KPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLV 658
           +  L+ P    P     VTS  AIA   Q   +   P     L+   A    GSP     
Sbjct: 710 RVGLFPP----PPPPPQVTS--AIATLQQAAAMSFCPQVARPLVGPLA---LGSPRLVRR 760

Query: 659 PVRAGPWASTSRLPAPPARTLHASLS-RAGRSQV--SLLGPP---PGGGGRRLGPRGRPL 712
           P      A+ S  P PPA    A  S RA R+     L   P   P    RRL    RPL
Sbjct: 761 PPPGPAPAAASPGPPPPASPPGAPASPRAPRTSPYGGLPAAPLAGPALPARRLSRASRPL 820

Query: 713 SASQPSLPQRATGDGSPGRKGSGS-ERLPPSGLLAKPPRTAQPPRPPVPEPATP 765
           SASQPSLP  A G  +  R  S S  RL P+     P   A  P P   + A+P
Sbjct: 821 SASQPSLPHGAPGPAASTRPASSSTPRLGPT-----PAARAAAPSPDRRDSASP 869



 Score = 31.6 bits (70), Expect = 2.9
 Identities = 15/37 (40%), Positives = 18/37 (48%)

Query: 6   RPAAGASEGATPGLEAVPPVAPPPATAASGPIPKSGP 42
           RP  G     +P L   PP  P PA A+ GP P + P
Sbjct: 744 RPLVGPLALGSPRLVRRPPPGPAPAAASPGPPPPASP 780


>gi|116325989 hyperpolarization activated cyclic nucleotide-gated
           potassium channel 1 [Homo sapiens]
          Length = 890

 Score =  883 bits (2282), Expect = 0.0
 Identities = 470/783 (60%), Positives = 564/783 (72%), Gaps = 70/783 (8%)

Query: 46  RRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMV 105
           +R   ++LQP VNKFSLR+FGS KAVE EQERVK+AG WIIHPYSDFRFYWDLIML++MV
Sbjct: 95  QRQFTSMLQPGVNKFSLRMFGSQKAVEKEQERVKTAGFWIIHPYSDFRFYWDLIMLIMMV 154

Query: 106 GNLIVLPVGITFFKEENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIR 165
           GNL+++PVGITFF E+ + PWI+FNV SDT FLLDL++NFRTG V E+ +EI+L P+ I+
Sbjct: 155 GNLVIIPVGITFFTEQTTTPWIIFNVASDTVFLLDLIMNFRTGTVNEDSSEIILDPKVIK 214

Query: 166 TRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLS 225
             YL++WF+VD ISSIPVDYIFL+VE    +D+EVYKTARALRIVRFTKILSLLRLLRLS
Sbjct: 215 MNYLKSWFVVDFISSIPVDYIFLIVE--KGMDSEVYKTARALRIVRFTKILSLLRLLRLS 272

Query: 226 RLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVS 285
           RLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVP+LQDFPPDCWVS
Sbjct: 273 RLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPLLQDFPPDCWVS 332

Query: 286 INHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGH 345
           +N MVN SWG+QYS+ALFKAMSHMLCIGYG QAPV M D+W+TMLSMIVGATCYAMF+GH
Sbjct: 333 LNEMVNDSWGKQYSYALFKAMSHMLCIGYGAQAPVSMSDLWITMLSMIVGATCYAMFVGH 392

Query: 346 ATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQGKMFDEESILGE 405
           ATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPAD RQ+IH+YYEHRYQGK+FDEE+IL E
Sbjct: 393 ATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADMRQKIHDYYEHRYQGKIFDEENILNE 452

Query: 406 LSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKM 465
           L++PLREEI+NF CR LVA MPLFA+ADP+FVTA+L+KLRFEVFQPGD ++REG+VG+KM
Sbjct: 453 LNDPLREEIVNFNCRKLVATMPLFANADPNFVTAMLSKLRFEVFQPGDYIIREGAVGKKM 512

Query: 466 YFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRADTYCRLYSLSVDHFNAV 525
           YFIQHG+  V+ + +++ +LTDGSYFGEICLLT+GRRTASVRADTYCRLYSLSVD+FN V
Sbjct: 513 YFIQHGVAGVITKSSKEMKLTDGSYFGEICLLTKGRRTASVRADTYCRLYSLSVDNFNEV 572

Query: 526 LEEFPMMRRAFETVAMDRLLRIGKKNSILQRK-RSEPSPG----SSGGIMEQHLVQHDRD 580
           LEE+PMMRRAFETVA+DRL RIGKKNSIL +K + + + G        I++Q +V+HDR+
Sbjct: 573 LEEYPMMRRAFETVAIDRLDRIGKKNSILLQKFQKDLNTGVFNNQENEILKQ-IVKHDRE 631

Query: 581 MARGVRGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPD-SPA 639
           M + +          L+       P      Q+  V +  +++ ++   P P +    P+
Sbjct: 632 MVQAIAPINYPQMTTLNSTSSTTTPTSRMRTQSPPVYTATSLSHSNLHSPSPSTQTPQPS 691

Query: 640 TLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPP-- 697
            +L+  ++ +A    SP  PV++   A T    +P A  L + + +  + QV    PP  
Sbjct: 692 AILSPCSYTTA--VCSP--PVQSPLAARTFHYASPTASQL-SLMQQQPQQQVQQSQPPQT 746

Query: 698 -----------PGGG--------------GRRLGPRGRPLSASQPSLP------------ 720
                      PG                   L    RPLSASQPSLP            
Sbjct: 747 QPQQPSPQPQTPGSSTPKNEVHKSTQALHNTNLTREVRPLSASQPSLPHEVSTLISRPHP 806

Query: 721 ----------QRATGDGSPGRKGSGSERLPPSGLL-------AKPPRTAQPPRPPVPEPA 763
                     Q  T     G +  G   +P    L       A PP    PP PP P  A
Sbjct: 807 TVGESLASIPQPVTAVPGTGLQAGGRSTVPQRVTLFRQMSSGAIPPNRGVPPAPPPPAAA 866

Query: 764 TPR 766
            PR
Sbjct: 867 LPR 869


>gi|4502917 cyclic nucleotide gated channel alpha 3 isoform 1 [Homo
           sapiens]
          Length = 694

 Score =  183 bits (464), Expect = 6e-46
 Identities = 133/501 (26%), Positives = 239/501 (47%), Gaps = 39/501 (7%)

Query: 74  EQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITF--FKEENSPPWIVFNV 131
           E+++ K   A ++ P S+  + W   + L +  N  +L     F   + E    W+V + 
Sbjct: 149 EEKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDY 208

Query: 132 LSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVE 191
            +D  ++LD+++  RTG + E+G  +    R  +     T F +D++S +P D  +L   
Sbjct: 209 SADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL--- 264

Query: 192 LEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 251
                     K       VRF       RLL+ SRL  +  + E     T      + RI
Sbjct: 265 ----------KVGTNYPEVRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRI 303

Query: 252 FNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMV--NHSWGRQYSHALFKAMSHM 309
            NL+  +L++ HW+ C+ F +     F  D WV  N  +  +    R+Y ++L+ +   +
Sbjct: 304 GNLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTL 363

Query: 310 LCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQ 369
             IG     PV   +    ++  +VG   +A  +G+  ++I ++++SR ++Q K   ++Q
Sbjct: 364 TTIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQ 422

Query: 370 YMSFHKLPADTRQRIHEYYEHRYQG-KMFDEESILGELSEPLREEIINFTCRGLVAHMPL 428
           YM F K+  D   R+  ++++ +   K  DE+ +L  L + L+ EI        +  + +
Sbjct: 423 YMQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRI 482

Query: 429 FAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLT 486
           F   +   +  ++ KLR  VF PGD + ++G +G++MY I  G L+V+A     +   L+
Sbjct: 483 FQDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLS 542

Query: 487 DGSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVA 540
           DGSYFGEI +L      +  RRTA++R+  Y  L+ LS D     L E+P  ++A E   
Sbjct: 543 DGSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKG 602

Query: 541 MDRLLRIGKKNSILQRKRSEP 561
              L++    +  L R  ++P
Sbjct: 603 RQILMKDNLIDEELARAGADP 623


>gi|120433600 cyclic nucleotide gated channel alpha 3 isoform 2
           [Homo sapiens]
          Length = 676

 Score =  181 bits (458), Expect = 3e-45
 Identities = 132/500 (26%), Positives = 238/500 (47%), Gaps = 39/500 (7%)

Query: 75  QERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITF--FKEENSPPWIVFNVL 132
           +++ K   A ++ P S+  + W   + L +  N  +L     F   + E    W+V +  
Sbjct: 132 RKKTKKKDAIVVDPSSNLYYRWLTAIALPVFYNWYLLICRACFDELQSEYLMLWLVLDYS 191

Query: 133 SDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVEL 192
           +D  ++LD+++  RTG + E+G  +    R  +     T F +D++S +P D  +L    
Sbjct: 192 ADVLYVLDVLVRARTGFL-EQGLMVSDTNRLWQHYKTTTQFKLDVLSLVPTDLAYL---- 246

Query: 193 EPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIF 252
                    K       VRF       RLL+ SRL  +  + E     T      + RI 
Sbjct: 247 ---------KVGTNYPEVRFN------RLLKFSRLFEFFDRTE-----TRTNYPNMFRIG 286

Query: 253 NLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMV--NHSWGRQYSHALFKAMSHML 310
           NL+  +L++ HW+ C+ F +     F  D WV  N  +  +    R+Y ++L+ +   + 
Sbjct: 287 NLVLYILIIIHWNACIYFAISKFIGFGTDSWVYPNISIPEHGRLSRKYIYSLYWSTLTLT 346

Query: 311 CIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 370
            IG     PV   +    ++  +VG   +A  +G+  ++I ++++SR ++Q K   ++QY
Sbjct: 347 TIGE-TPPPVKDEEYLFVVVDFLVGVLIFATIVGNVGSMISNMNASRAEFQAKIDSIKQY 405

Query: 371 MSFHKLPADTRQRIHEYYEHRYQG-KMFDEESILGELSEPLREEIINFTCRGLVAHMPLF 429
           M F K+  D   R+  ++++ +   K  DE+ +L  L + L+ EI        +  + +F
Sbjct: 406 MQFRKVTKDLETRVIRWFDYLWANKKTVDEKEVLKSLPDKLKAEIAINVHLDTLKKVRIF 465

Query: 430 AHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTD 487
              +   +  ++ KLR  VF PGD + ++G +G++MY I  G L+V+A     +   L+D
Sbjct: 466 QDCEAGLLVELVLKLRPTVFSPGDYICKKGDIGKEMYIINEGKLAVVADDGVTQFVVLSD 525

Query: 488 GSYFGEICLL------TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAM 541
           GSYFGEI +L      +  RRTA++R+  Y  L+ LS D     L E+P  ++A E    
Sbjct: 526 GSYFGEISILNIKGSKSGNRRTANIRSIGYSDLFCLSKDDLMEALTEYPEAKKALEEKGR 585

Query: 542 DRLLRIGKKNSILQRKRSEP 561
             L++    +  L R  ++P
Sbjct: 586 QILMKDNLIDEELARAGADP 605


>gi|13540549 potassium voltage-gated channel, subfamily H, member 6
           isoform 1 [Homo sapiens]
          Length = 994

 Score =  174 bits (441), Expect = 3e-43
 Identities = 148/565 (26%), Positives = 245/565 (43%), Gaps = 88/565 (15%)

Query: 35  GPIPKSGPEPKRRHLGTLLQPTVN--KFSLR-----------VFGSHKAVEIEQE----- 76
           GP P +G   K R +  + Q T+N  +F+L            +   HK VE  Q      
Sbjct: 165 GPGPGTG-RGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKV 223

Query: 77  -RVKSAGA---------------WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE 120
            +V S GA               W I  YS F+  WD ++LLL++   +  P    F   
Sbjct: 224 TQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLS 283

Query: 121 ENSP-----------PWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYL 169
           +              P  V +++ D  F++D+V+NFRT   V    E++  PR I   Y 
Sbjct: 284 DQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRT-TYVNTNDEVVSHPRRIAVHYF 342

Query: 170 RTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIR 229
           + WFL+D++++IP D +             +++T         T ++ LL+  RL RL+R
Sbjct: 343 KGWFLIDMVAAIPFDLL-------------IFRTGSD----ETTTLIGLLKTARLLRLVR 385

Query: 230 YIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLV-----PMLQD---FPPD 281
              + +      Y    A V +F L+    L+ HW  C+ + +     P L+    +   
Sbjct: 386 VARKLDR-----YSEYGAAV-LFLLMCTFALIAHWLACIWYAIGNVERPYLEHKIGWLDS 439

Query: 282 CWVSINHMVNHSWGR-------QYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIV 334
             V +    N S          +Y  AL+   S +  +G+G  +P    +   ++  M++
Sbjct: 440 LGVQLGKRYNGSDPASGPSVQDKYVTALYFTFSSLTSVGFGNVSPNTNSEKVFSICVMLI 499

Query: 335 GATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ- 393
           G+  YA   G+ +A+IQ L S   +Y  +  +V++++ FH++P   RQR+ EY++H +  
Sbjct: 500 GSLMYASIFGNVSAIIQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSY 559

Query: 394 GKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGD 453
               D  ++L    E L+ +I     R L+ H P F+ A    + A+  K +     PGD
Sbjct: 560 TNGIDMNAVLKGFPECLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGD 619

Query: 454 LVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLL--TRGRRTASVRADTY 511
            +V  G V   +YFI  G + +L        L     FGE   L    G+ +A VRA TY
Sbjct: 620 TLVHLGDVLSTLYFISRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTY 679

Query: 512 CRLYSLSVDHFNAVLEEFPMMRRAF 536
           C L+ +       VL+ +P    +F
Sbjct: 680 CDLHKIQRADLLEVLDMYPAFAESF 704


>gi|26051273 voltage-gated potassium channel, subfamily H, member 2
           isoform c [Homo sapiens]
          Length = 819

 Score =  172 bits (436), Expect = 1e-42
 Identities = 137/536 (25%), Positives = 232/536 (43%), Gaps = 62/536 (11%)

Query: 24  PVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVEIEQERVKSAGA 83
           P      T A  P  + G   +   + +L+   V      V   +K   ++  R+     
Sbjct: 4   PAGKASRTGALRPRAQKGRVRRAVRISSLVAQEVLSLGADVLPEYK---LQAPRIHR--- 57

Query: 84  WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENSP---------PWIVFNV 131
           W I  YS F+  WD ++LLL++   +  P    F     EE  P         P  V ++
Sbjct: 58  WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 117

Query: 132 LSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVE 191
           + D  F++D+++NFRT   V    E++  P  I   Y + WFL+D++++IP D +     
Sbjct: 118 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 176

Query: 192 LEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 251
            E  +   + KTAR LR+VR  +        +L R   Y               +AV  +
Sbjct: 177 SEELIG--LLKTARLLRLVRVAR--------KLDRYSEY--------------GAAV--L 210

Query: 252 FNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH----------- 300
           F L+    L+ HW  C+ + +  ++    D  +   H +    G+ Y+            
Sbjct: 211 FLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDK 270

Query: 301 ---ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 357
              AL+   S +  +G+G  +P    +   ++  M++G+  YA   G+ +A+IQ L S  
Sbjct: 271 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 330

Query: 358 RQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIIN 416
            +Y  +  +V +++ FH++P   RQR+ EY++H +      D  ++L    E L+ +I  
Sbjct: 331 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICL 390

Query: 417 FTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVL 476
              R L+ H   F  A    + A+  K +     PGD +V  G +   +YFI  G + +L
Sbjct: 391 HLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 450

Query: 477 ARGARDTRLTDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDHFNAVLEEFP 530
                   L     FGE + L  R G+    VRA TYC L+ +  D    VL+ +P
Sbjct: 451 RGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 506


>gi|4557729 voltage-gated potassium channel, subfamily H, member 2
           isoform a [Homo sapiens]
          Length = 1159

 Score =  171 bits (434), Expect = 2e-42
 Identities = 127/476 (26%), Positives = 213/476 (44%), Gaps = 56/476 (11%)

Query: 84  WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENSP---------PWIVFNV 131
           W I  YS F+  WD ++LLL++   +  P    F     EE  P         P  V ++
Sbjct: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457

Query: 132 LSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVE 191
           + D  F++D+++NFRT   V    E++  P  I   Y + WFL+D++++IP D +     
Sbjct: 458 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 516

Query: 192 LEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 251
            E  +   + KTAR LR+VR  +        +L R   Y               +AV  +
Sbjct: 517 SEELIG--LLKTARLLRLVRVAR--------KLDRYSEY--------------GAAV--L 550

Query: 252 FNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH----------- 300
           F L+    L+ HW  C+ + +  ++    D  +   H +    G+ Y+            
Sbjct: 551 FLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDK 610

Query: 301 ---ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 357
              AL+   S +  +G+G  +P    +   ++  M++G+  YA   G+ +A+IQ L S  
Sbjct: 611 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 670

Query: 358 RQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIIN 416
            +Y  +  +V +++ FH++P   RQR+ EY++H +      D  ++L    E L+ +I  
Sbjct: 671 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICL 730

Query: 417 FTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVL 476
              R L+ H   F  A    + A+  K +     PGD +V  G +   +YFI  G + +L
Sbjct: 731 HLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 790

Query: 477 ARGARDTRLTDGSYFGE-ICLLTR-GRRTASVRADTYCRLYSLSVDHFNAVLEEFP 530
                   L     FGE + L  R G+    VRA TYC L+ +  D    VL+ +P
Sbjct: 791 RGDVVVAILGKNDIFGEPLNLYARPGKSNGDVRALTYCDLHKIHRDDLLEVLDMYP 846


>gi|6912446 potassium voltage-gated channel, subfamily H, member 4
           [Homo sapiens]
          Length = 1017

 Score =  167 bits (422), Expect = 4e-41
 Identities = 175/694 (25%), Positives = 287/694 (41%), Gaps = 106/694 (15%)

Query: 46  RRHLGTLLQPTVNKFSLRVFGSHKA--------VEIEQERVKSAGA---WIIHPYSDFRF 94
           RR   T+L      F  R  G  KA          + + +V S G     ++H YS  + 
Sbjct: 169 RRRSRTVLHRLTGHFGRRGQGGMKANNNVFEPKPSVPEYKVASVGGSRCLLLH-YSVSKA 227

Query: 95  YWDLIMLLLMVGNLIVLPVGITFFKEENSP----PWIVFNVLSDTFFLLDLVLNFRTGIV 150
            WD ++LL      + +P  + F  ++++P      +V ++  +  F+LD++LNFRT  V
Sbjct: 228 IWDGLILLATFYVAVTVPYNVCFSGDDDTPITSRHTLVSDIAVEMLFILDIILNFRTTYV 287

Query: 151 VEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIV 210
            + G +++ APR+I   YL TWF +DLI+++P D +++                     +
Sbjct: 288 SQSG-QVISAPRSIGLHYLATWFFIDLIAALPFDLLYIFN-------------------I 327

Query: 211 RFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQF 270
             T ++ LL+ +RL RL+R + + E      Y   SAVV    L+ +  LL HW  C+ +
Sbjct: 328 TVTSLVHLLKTVRLLRLLRLLQKLER-----YSQCSAVVLTL-LMSVFALLAHWMACIWY 381

Query: 271 LV---------PMLQDFPPDCWVS----------INHMVNHSWGRQ-YSHALFKAMSHML 310
           ++         P+L D     W+           +N  V     R  Y  AL+  +S + 
Sbjct: 382 VIGRREMEANDPLLWDIG---WLHELGKRLEVPYVNGSVGGPSRRSAYIAALYFTLSSLT 438

Query: 311 CIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQY 370
            +G+G        +   ++ +M++GA  +A+  G+ TA+IQ + S R  Y  + K ++ +
Sbjct: 439 SVGFGNVCANTDAEKIFSICTMLIGALMHAVVFGNVTAIIQRMYSRRSLYHSRMKDLKDF 498

Query: 371 MSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIINFTCRGLVAHMPLF 429
           +  H+LP   +QR+ EY++  +      D   +L +  + LR +I     R ++  +PLF
Sbjct: 499 IRVHRLPRPLKQRMLEYFQTTWAVNSGIDANELLRDFPDELRADIAMHLNREIL-QLPLF 557

Query: 430 AHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGS 489
             A    + A+   ++     PG+ ++R G   +  Y++  G L VL        L  G 
Sbjct: 558 GAASRGCLRALSLHIKTSFCAPGEYLLRRGDALQAHYYVCSGSLEVLRDNMVLAILGKGD 617

Query: 490 YFG----------------EICLLTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMR 533
             G                   L T    +A V+A TYC L  LS      VL  +P   
Sbjct: 618 LIGADIPEPGQEPGLGADPNFVLKT----SADVKALTYCGLQQLSSRGLAEVLRLYPEYG 673

Query: 534 RAFETVAMDRL---LRIGKKNSILQR-----KRSEPSPGSSGGIMEQHLVQHDRDMARGV 585
            AF       L   LR G   S L R     + S+P   S G   ++ L           
Sbjct: 674 AAFRAGLPRDLTFNLRQGSDTSGLSRFSRSPRLSQPRSESLGSSSDKTLPSITE------ 727

Query: 586 RGRAPSTGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARS 645
                 +GA+  G P    PL+   L  A    ++   L  +  P      SP+   + S
Sbjct: 728 ----AESGAEPGGGPRPRRPLLLPNLSPARPRGSLVSLLGEELPPFSALVSSPSLSPSLS 783

Query: 646 -AWRSAGSPASPLVPVRAGPWASTSRLPAPPART 678
            A    G  ASP  P R        +L  PP  T
Sbjct: 784 PALAGQGHSASPHGPPRCSAAWKPPQLLIPPLGT 817


>gi|4504831 potassium voltage-gated channel, subfamily H, member 1
           isoform 2 [Homo sapiens]
          Length = 962

 Score =  164 bits (416), Expect = 2e-40
 Identities = 133/526 (25%), Positives = 231/526 (43%), Gaps = 62/526 (11%)

Query: 66  GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 125
           GS    + +QE  K+    I+H Y  F+  WD I+L+L     I++P  ++F   +N+  
Sbjct: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249

Query: 126 WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY 185
           W+V + + D  FL+D+VLNF T  V   G E++  P+ IR  YL+TWF++DL+S +P D 
Sbjct: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYD- 307

Query: 186 IFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 245
              V+     +D  +     +L++V         RLLRL R+ R +  + E     Y  A
Sbjct: 308 ---VINAFENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYIE-----YGAA 350

Query: 246 SAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQ-------- 297
             V+    L+ +  L  HW  C+ + +   + F  D       + N+SW  Q        
Sbjct: 351 VLVL----LVCVFGLAAHWMACIWYSIGDYEIFDED----TKTIRNNSWLYQLAMDIGTP 402

Query: 298 --------------------YSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGAT 337
                               Y  +L+  M+ +  +G+G  AP    +    +  M++G+ 
Sbjct: 403 YQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIAPSTDIEKIFAVAIMMIGSL 462

Query: 338 CYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QGKM 396
            YA   G+ T + Q + ++  +Y E    V  ++  +++P    +R+ +Y    +   + 
Sbjct: 463 LYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPKGLSERVMDYIVSTWSMSRG 522

Query: 397 FDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVV 456
            D E +L    + +R +I     R +    P F  A    + A+  + +     PGDL+ 
Sbjct: 523 IDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCLRALAMEFQTVHCAPGDLIY 582

Query: 457 REGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICL--LTRGRRTASVRADTYCRL 514
             G     + F+  G L V+        L  G  FG++     T  +  A+VRA TYC L
Sbjct: 583 HAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWKEATLAQSCANVRALTYCDL 642

Query: 515 YSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSE 560
           + +  D    VLE +     +F   + + +L    +  I+ RK S+
Sbjct: 643 HVIKRDALQKVLEFYTAFSHSF---SRNLILTYNLRKRIVFRKISD 685


>gi|22024390 potassium voltage-gated channel, subfamily H, member 5
           isoform 1 [Homo sapiens]
          Length = 988

 Score =  164 bits (415), Expect = 3e-40
 Identities = 132/521 (25%), Positives = 231/521 (44%), Gaps = 53/521 (10%)

Query: 66  GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 125
           GS    + +QE  K+    I+H Y  F+  WD ++L+L     I++P  ++F  ++N+  
Sbjct: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246

Query: 126 WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY 185
           W+V + + D  FL+D+VLNF T   V  G E++  P+ IR  YL+TWF++DL+S +P D 
Sbjct: 247 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYD- 304

Query: 186 IFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 245
              ++     +D  +     +L++V         RLLRL R+ R +  + E     Y  A
Sbjct: 305 ---IINAFENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLE-----YGAA 347

Query: 246 SAVVRIFNLIGMMLLLCHWDGCLQFLV-------PMLQDFPPDCW-------VSINHMVN 291
             V+    L+ +  L+ HW  C+ + +        +      D W       +   +  N
Sbjct: 348 VLVL----LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 403

Query: 292 HSWG---------RQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMF 342
            S G           Y  +L+  M+ +  IG+G  AP    +   ++  M+VG+  YA  
Sbjct: 404 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463

Query: 343 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QGKMFDEES 401
            G+ T + Q + ++  +Y E    V  ++  +++P    +R+ +Y    +   K  D E 
Sbjct: 464 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 523

Query: 402 ILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSV 461
           +L    + +R +I     R +    P F  A    + A+  + +     PGDL+   G  
Sbjct: 524 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 583

Query: 462 GRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICL--LTRGRRTASVRADTYCRLYSLSV 519
              + F+  G L V+        L  G  FG+I     T     A+VRA TYC L+ +  
Sbjct: 584 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 643

Query: 520 DHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQRKRSE 560
           +    VL+ +     +F   + +  L    +  I+ RK S+
Sbjct: 644 EALLKVLDFYTAFANSF---SRNLTLTCNLRKRIIFRKISD 681


>gi|42718011 cyclic nucleotide gated channel alpha 2 [Homo sapiens]
          Length = 664

 Score =  164 bits (415), Expect = 3e-40
 Identities = 122/480 (25%), Positives = 228/480 (47%), Gaps = 43/480 (8%)

Query: 84  WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSP--PWIVFNVLSDTFFLLDL 141
           +++ P  D+ + W  ++ + ++ N  +L     F   +      W+V + +SD  ++ DL
Sbjct: 131 FVLDPAGDWYYCWLFVIAMPVLYNWCLLVARACFSDLQKGYYLVWLVLDYVSDVVYIADL 190

Query: 142 VLNFRTGIVVEEGAEILLAPRAIRTRYLRTW-FLVDLISSIPVDYIFLVVELEPRLDAEV 200
            +  RTG + E+G  ++   + +R  Y+ T  F +D+ S IP D I+  V++        
Sbjct: 191 FIRLRTGFL-EQGL-LVKDTKKLRDNYIHTLQFKLDVASIIPTDLIYFAVDIHSPE---- 244

Query: 201 YKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLL 260
                    VRF       RLL  +R+  +  + E     T      + RI NL+  +L+
Sbjct: 245 ---------VRFN------RLLHFARMFEFFDRTE-----TRTNYPNIFRISNLVLYILV 284

Query: 261 LCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWG---RQYSHALFKAMSHMLCIGYGQQ 317
           + HW+ C+ + +     F  D WV  N + +  +G   R+Y + L+ +   +  IG    
Sbjct: 285 IIHWNACIYYAISKSIGFGVDTWVYPN-ITDPEYGYLAREYIYCLYWSTLTLTTIGE-TP 342

Query: 318 APVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLP 377
            PV   +    +   ++G   +A  +G+  ++I +++++R ++Q K   V+ YM F K+ 
Sbjct: 343 PPVKDEEYLFVIFDFLIGVLIFATIVGNVGSMISNMNATRAEFQAKIDAVKHYMQFRKVS 402

Query: 378 ADTRQRIHEYYEHRYQGKM-FDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSF 436
                ++  ++++ +  K   DE  IL  L   LR EI        +  + +F   +   
Sbjct: 403 KGMEAKVIRWFDYLWTNKKTVDEREILKNLPAKLRAEIAINVHLSTLKKVRIFHDCEAGL 462

Query: 437 VTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTDGSYFGEI 494
           +  ++ KLR +VF PGD + R+G +G++MY I+ G L+V+A     +   L+ GS FGEI
Sbjct: 463 LVELVLKLRPQVFSPGDYICRKGDIGKEMYIIKEGKLAVVADDGVTQYALLSAGSCFGEI 522

Query: 495 CLLT------RGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIG 548
            +L         RRTA++R+  Y  L+ LS D     + E+P  ++  E    + L++ G
Sbjct: 523 SILNIKGSKMGNRRTANIRSLGYSDLFCLSKDDLMEAVTEYPDAKKVLEERGREILMKEG 582


>gi|27886648 potassium voltage-gated channel, subfamily H, member 5
           isoform 2 [Homo sapiens]
          Length = 624

 Score =  164 bits (414), Expect = 4e-40
 Identities = 127/497 (25%), Positives = 221/497 (44%), Gaps = 50/497 (10%)

Query: 66  GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 125
           GS    + +QE  K+    I+H Y  F+  WD ++L+L     I++P  ++F  ++N+  
Sbjct: 130 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 188

Query: 126 WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY 185
           W+V + + D  FL+D+VLNF T   V  G E++  P+ IR  YL+TWF++DL+S +P D 
Sbjct: 189 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYD- 246

Query: 186 IFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 245
              ++     +D  +     +L++V         RLLRL R+ R +  + E     Y  A
Sbjct: 247 ---IINAFENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLE-----YGAA 289

Query: 246 SAVVRIFNLIGMMLLLCHWDGCLQFLV-------PMLQDFPPDCW-------VSINHMVN 291
             V+    L+ +  L+ HW  C+ + +        +      D W       +   +  N
Sbjct: 290 VLVL----LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 345

Query: 292 HSWG---------RQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMF 342
            S G           Y  +L+  M+ +  IG+G  AP    +   ++  M+VG+  YA  
Sbjct: 346 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 405

Query: 343 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QGKMFDEES 401
            G+ T + Q + ++  +Y E    V  ++  +++P    +R+ +Y    +   K  D E 
Sbjct: 406 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 465

Query: 402 ILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSV 461
           +L    + +R +I     R +    P F  A    + A+  + +     PGDL+   G  
Sbjct: 466 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 525

Query: 462 GRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICL--LTRGRRTASVRADTYCRLYSLSV 519
              + F+  G L V+        L  G  FG+I     T     A+VRA TYC L+ +  
Sbjct: 526 VDALCFVVSGSLEVIQDDEVVAILGKGDVFGDIFWKETTLAHACANVRALTYCDLHIIKR 585

Query: 520 DHFNAVLEEFPMMRRAF 536
           +    VL+ +     +F
Sbjct: 586 EALLKVLDFYTAFANSF 602


>gi|82617546 cyclic nucleotide gated channel alpha 4 [Homo sapiens]
          Length = 575

 Score =  163 bits (413), Expect = 5e-40
 Identities = 125/480 (26%), Positives = 230/480 (47%), Gaps = 43/480 (8%)

Query: 85  IIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENS--PPWIVFNVLSDTFFLLDLV 142
           ++ P  D+ ++W   M+  ++ NLI+L     F   ++     W+V +  SD  +LLD+V
Sbjct: 26  VLDPSGDYYYWWLNTMVFPVMYNLIILVCRACFPDLQHGYLVAWLVLDYTSDLLYLLDMV 85

Query: 143 LNFRTGIVVEEGAEILLAPRAIRTRYLRTW-FLVDLISSIPVDYIFLVVELEPRLDAEVY 201
           + F TG + E+G  ++   R I +RY+RTW F +DL S +P D +++             
Sbjct: 86  VRFHTGFL-EQGILVVDKGR-ISSRYVRTWSFFLDLASLMPTDVVYV------------- 130

Query: 202 KTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLL 261
                 R+   T  L L R LR  RL     + E     T        RI  L+  + ++
Sbjct: 131 ------RLGPHTPTLRLNRFLRAPRLFEAFDRTE-----TRTAYPNAFRIAKLMLYIFVV 179

Query: 262 CHWDGCLQFLVPMLQDFPPDCWVSINHMVN--HSWGRQYSHALFKAMSHMLCIGYGQQAP 319
            HW+ CL F +     F  D WV  +          RQY ++ +   S ++    G   P
Sbjct: 180 IHWNSCLYFALSRYLGFGRDAWVYPDPAQPGFERLRRQYLYSFY--FSTLILTTVGDTPP 237

Query: 320 VGMPDVWLTMLS-MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPA 378
               + +L M+   ++    +A  +G  +++I +++++   +   +  V++YM    +  
Sbjct: 238 PAREEEYLFMVGDFLLAVMGFATIMGSMSSVIYNMNTADAAFYPDHALVKKYMKLQHVNR 297

Query: 379 DTRQRIHEYYEH-RYQGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFV 437
              +R+ ++Y+H +   KM +E +IL  L E LR E+        ++ + +F + + S +
Sbjct: 298 KLERRVIDWYQHLQINKKMTNEVAILQHLPERLRAEVAVSVHLSTLSRVQIFQNCEASLL 357

Query: 438 TAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTDGSYFGEIC 495
             ++ KL+ + + PG+ V R+G +G++MY I+ G L+V+A     +   L  G YFGEI 
Sbjct: 358 EELVLKLQPQTYSPGEYVCRKGDIGQEMYIIREGQLAVVADDGITQYAVLGAGLYFGEIS 417

Query: 496 L------LTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGK 549
           +      ++  RRTA++++  Y  L+ LS +    VL E+P  +   E    + LL++ K
Sbjct: 418 IINIKGNMSGNRRTANIKSLGYSDLFCLSKEDLREVLSEYPQAQTIMEEKGREILLKMNK 477


>gi|217035093 cyclic nucleotide gated channel alpha 1 isoform 1
           [Homo sapiens]
          Length = 759

 Score =  163 bits (412), Expect = 6e-40
 Identities = 120/490 (24%), Positives = 232/490 (47%), Gaps = 39/490 (7%)

Query: 85  IIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITF--FKEENSPPWIVFNVLSDTFFLLDLV 142
           +I P  +  + W   + L ++ N  ++     F   + +    W++ + +SD  +L+D+ 
Sbjct: 226 VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMF 285

Query: 143 LNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYK 202
           +  RTG + E+G  +    + I        F +D++S IP D ++  +          Y 
Sbjct: 286 VRTRTGYL-EQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWN-------YP 337

Query: 203 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLC 262
             R            L RLLR SR+  +  + E     T      + RI NL+  ++++ 
Sbjct: 338 EIR------------LNRLLRFSRMFEFFQRTE-----TRTNYPNIFRISNLVMYIVIII 380

Query: 263 HWDGCLQFLVPMLQDFPPDCWV--SINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPV 320
           HW+ C+ + +     F  D WV   IN        R+Y ++L+ +   +  IG     PV
Sbjct: 381 HWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGE-TPPPV 439

Query: 321 GMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADT 380
              +    ++  ++G   +A  +G+  ++I +++++R ++Q +   ++QYM F  +  D 
Sbjct: 440 RDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDM 499

Query: 381 RQRIHEYYEHRYQGKM-FDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTA 439
            +R+ +++++ +  K   DE+ +L  L + LR EI        +  + +FA  +   +  
Sbjct: 500 EKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVE 559

Query: 440 VLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTDGSYFGEICLL 497
           ++ KL+ +V+ PGD + ++G +GR+MY I+ G L+V+A     +   L+DGSYFGEI +L
Sbjct: 560 LVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISIL 619

Query: 498 ------TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKN 551
                    RRTA++++  Y  L+ LS D     L E+P  +   E      L++ G  +
Sbjct: 620 NIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLD 679

Query: 552 SILQRKRSEP 561
             +    S+P
Sbjct: 680 LNIANAGSDP 689


>gi|71143141 cyclic nucleotide gated channel alpha 1 isoform 2 [Homo
           sapiens]
          Length = 690

 Score =  163 bits (412), Expect = 6e-40
 Identities = 120/490 (24%), Positives = 232/490 (47%), Gaps = 39/490 (7%)

Query: 85  IIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITF--FKEENSPPWIVFNVLSDTFFLLDLV 142
           +I P  +  + W   + L ++ N  ++     F   + +    W++ + +SD  +L+D+ 
Sbjct: 157 VIDPSGNTYYNWLFCITLPVMYNWTMVIARACFDELQSDYLEYWLILDYVSDIVYLIDMF 216

Query: 143 LNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYK 202
           +  RTG + E+G  +    + I        F +D++S IP D ++  +          Y 
Sbjct: 217 VRTRTGYL-EQGLLVKEELKLINKYKSNLQFKLDVLSLIPTDLLYFKLGWN-------YP 268

Query: 203 TARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLC 262
             R            L RLLR SR+  +  + E     T      + RI NL+  ++++ 
Sbjct: 269 EIR------------LNRLLRFSRMFEFFQRTE-----TRTNYPNIFRISNLVMYIVIII 311

Query: 263 HWDGCLQFLVPMLQDFPPDCWV--SINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPV 320
           HW+ C+ + +     F  D WV   IN        R+Y ++L+ +   +  IG     PV
Sbjct: 312 HWNACVFYSISKAIGFGNDTWVYPDINDPEFGRLARKYVYSLYWSTLTLTTIGE-TPPPV 370

Query: 321 GMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADT 380
              +    ++  ++G   +A  +G+  ++I +++++R ++Q +   ++QYM F  +  D 
Sbjct: 371 RDSEYVFVVVDFLIGVLIFATIVGNIGSMISNMNAARAEFQARIDAIKQYMHFRNVSKDM 430

Query: 381 RQRIHEYYEHRYQGKM-FDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTA 439
            +R+ +++++ +  K   DE+ +L  L + LR EI        +  + +FA  +   +  
Sbjct: 431 EKRVIKWFDYLWTNKKTVDEKEVLKYLPDKLRAEIAINVHLDTLKKVRIFADCEAGLLVE 490

Query: 440 VLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARG--ARDTRLTDGSYFGEICLL 497
           ++ KL+ +V+ PGD + ++G +GR+MY I+ G L+V+A     +   L+DGSYFGEI +L
Sbjct: 491 LVLKLQPQVYSPGDYICKKGDIGREMYIIKEGKLAVVADDGVTQFVVLSDGSYFGEISIL 550

Query: 498 ------TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKN 551
                    RRTA++++  Y  L+ LS D     L E+P  +   E      L++ G  +
Sbjct: 551 NIKGSKAGNRRTANIKSIGYSDLFCLSKDDLMEALTEYPDAKTMLEEKGKQILMKDGLLD 610

Query: 552 SILQRKRSEP 561
             +    S+P
Sbjct: 611 LNIANAGSDP 620


>gi|27886651 potassium voltage-gated channel, subfamily H, member 6
           isoform 2 [Homo sapiens]
          Length = 905

 Score =  162 bits (411), Expect = 8e-40
 Identities = 140/550 (25%), Positives = 229/550 (41%), Gaps = 111/550 (20%)

Query: 35  GPIPKSGPEPKRRHLGTLLQPTVN--KFSLR-----------VFGSHKAVEIEQE----- 76
           GP P +G   K R +  + Q T+N  +F+L            +   HK VE  Q      
Sbjct: 165 GPGPGTG-RGKYRTISQIPQFTLNFVEFNLEKHRSSSTTEIEIIAPHKVVERTQNVTEKV 223

Query: 77  -RVKSAGA---------------WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKE 120
            +V S GA               W I  YS F+  WD ++LLL++   +  P    F   
Sbjct: 224 TQVLSLGADVLPEYKLQAPRIHRWTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLS 283

Query: 121 ENSP-----------PWIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYL 169
           +              P  V +++ D  F++D+V+NFRT   V    E++  PR I   Y 
Sbjct: 284 DQDESRRGACSYTCSPLTVVDLIVDIMFVVDIVINFRT-TYVNTNDEVVSHPRRIAVHYF 342

Query: 170 RTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIR 229
           + WFL+D++++IP D +             +++T         T ++ LL+  RL RL+R
Sbjct: 343 KGWFLIDMVAAIPFDLL-------------IFRTGSD----ETTTLIGLLKTARLLRLVR 385

Query: 230 YIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHM 289
              + +      Y    A V +F L+    L+ HW  C+  L                  
Sbjct: 386 VARKLDR-----YSEYGAAV-LFLLMCTFALIAHWLACICSLTS---------------- 423

Query: 290 VNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATAL 349
                                 +G+G  +P    +   ++  M++G+  YA   G+ +A+
Sbjct: 424 ----------------------VGFGNVSPNTNSEKVFSICVMLIGSLMYASIFGNVSAI 461

Query: 350 IQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSE 408
           IQ L S   +Y  +  +V++++ FH++P   RQR+ EY++H +      D  ++L    E
Sbjct: 462 IQRLYSGTARYHTQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPE 521

Query: 409 PLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFI 468
            L+ +I     R L+ H P F+ A    + A+  K +     PGD +V  G V   +YFI
Sbjct: 522 CLQADICLHLHRALLQHCPAFSGAGKGCLRALAVKFKTTHAPPGDTLVHLGDVLSTLYFI 581

Query: 469 QHGLLSVLARGARDTRLTDGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDHFNAVL 526
             G + +L        L     FGE   L    G+ +A VRA TYC L+ +       VL
Sbjct: 582 SRGSIEILRDDVVVAILGKNDIFGEPVSLHAQPGKSSADVRALTYCDLHKIQRADLLEVL 641

Query: 527 EEFPMMRRAF 536
           + +P    +F
Sbjct: 642 DMYPAFAESF 651


>gi|27437001 potassium voltage-gated channel, subfamily H, member 1
           isoform 1 [Homo sapiens]
          Length = 989

 Score =  158 bits (399), Expect = 2e-38
 Identities = 134/545 (24%), Positives = 232/545 (42%), Gaps = 73/545 (13%)

Query: 66  GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 125
           GS    + +QE  K+    I+H Y  F+  WD I+L+L     I++P  ++F   +N+  
Sbjct: 191 GSDILPQYKQEAPKTPPHIILH-YCVFKTTWDWIILILTFYTAILVPYNVSFKTRQNNVA 249

Query: 126 WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY 185
           W+V + + D  FL+D+VLNF T  V   G E++  P+ IR  YL+TWF++DL+S +P D 
Sbjct: 250 WLVVDSIVDVIFLVDIVLNFHTTFVGPAG-EVISDPKLIRMNYLKTWFVIDLLSCLPYDV 308

Query: 186 -------------------IFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSR 226
                              I    ++ P L+        +  I      L ++RLLRL R
Sbjct: 309 INAFENVDEVSAFMGDPGKIGFADQIPPPLEGR-----ESQGISSLFSSLKVVRLLRLGR 363

Query: 227 LIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSI 286
           + R +  + E     Y  A  V+    L+ +  L  HW  C+ + +   + F  D     
Sbjct: 364 VARKLDHYIE-----YGAAVLVL----LVCVFGLAAHWMACIWYSIGDYEIFDED----T 410

Query: 287 NHMVNHSWGRQ----------------------------YSHALFKAMSHMLCIGYGQQA 318
             + N+SW  Q                            Y  +L+  M+ +  +G+G  A
Sbjct: 411 KTIRNNSWLYQLAMDIGTPYQFNGSGSGKWEGGPSKNSVYISSLYFTMTSLTSVGFGNIA 470

Query: 319 PVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPA 378
           P    +    +  M++G+  YA   G+ T + Q + ++  +Y E    V  ++  +++P 
Sbjct: 471 PSTDIEKIFAVAIMMIGSLLYATIFGNVTTIFQQMYANTNRYHEMLNSVRDFLKLYQVPK 530

Query: 379 DTRQRIHEYYEHRY-QGKMFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFV 437
              +R+ +Y    +   +  D E +L    + +R +I     R +    P F  A    +
Sbjct: 531 GLSERVMDYIVSTWSMSRGIDTEKVLQICPKDMRADICVHLNRKVFKEHPAFRLASDGCL 590

Query: 438 TAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICL- 496
            A+  + +     PGDL+   G     + F+  G L V+        L  G  FG++   
Sbjct: 591 RALAMEFQTVHCAPGDLIYHAGESVDSLCFVVSGSLEVIQDDEVVAILGKGDVFGDVFWK 650

Query: 497 -LTRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKKNSILQ 555
             T  +  A+VRA TYC L+ +  D    VLE +     +F   + + +L    +  I+ 
Sbjct: 651 EATLAQSCANVRALTYCDLHVIKRDALQKVLEFYTAFSHSF---SRNLILTYNLRKRIVF 707

Query: 556 RKRSE 560
           RK S+
Sbjct: 708 RKISD 712


>gi|27886653 potassium voltage-gated channel, subfamily H, member 7
           isoform 1 [Homo sapiens]
          Length = 1196

 Score =  157 bits (396), Expect = 5e-38
 Identities = 129/486 (26%), Positives = 219/486 (45%), Gaps = 60/486 (12%)

Query: 85  IIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENS--------PPWIVFNVLS 133
           I+H YS F+  WD ++LLL++   I  P    F    +EE           P  V +++ 
Sbjct: 400 ILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIV 458

Query: 134 DTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY-IFLVVEL 192
           D  F++D+++NFRT   V +  E++  P  I   Y + WFL+D++++IP D  IF     
Sbjct: 459 DIMFIIDILINFRT-TYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSD 517

Query: 193 EPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIF 252
           E      + KTAR LR+VR  +        +L R   Y               +AV+ + 
Sbjct: 518 ETTTLIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLML- 554

Query: 253 NLIGMMLLLCHWDGCLQFLV-----PMLQDFPPDCWV-SINHMVNHSWGR---------- 296
            L+ +  L+ HW  C+ + +     P L D     W+ S+   +   +            
Sbjct: 555 -LMCIFALIAHWLACIWYAIGNVERPYLTD--KIGWLDSLGQQIGKRYNDSDSSSGPSIK 611

Query: 297 -QYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDS 355
            +Y  AL+   S +  +G+G  +P    +   ++  M++G+  YA   G+ +A+IQ L S
Sbjct: 612 DKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYS 671

Query: 356 SRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QGKMFDEESILGELSEPLREEI 414
              +Y  +  +V++++ FH++P   RQR+ EY++H +      D   +L    E L+ +I
Sbjct: 672 GTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAWTYTNGIDMNMVLKGFPECLQADI 731

Query: 415 INFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLS 474
                + L+ +   F  A    + A+  K +     PGD +V  G V   +YF+  G + 
Sbjct: 732 CLHLNQTLLQNCKAFRGASKGCLRALAMKFKTTHAPPGDTLVHCGDVLTALYFLSRGSIE 791

Query: 475 VLARGARDTRLTDGSYFGEICLL--TRGRRTASVRADTYCRLYSLSVDHFNAVLEEFPMM 532
           +L        L     FGE+  L    G+  A VRA TYC L+ +  +    VL+ +P  
Sbjct: 792 ILKDDIVVAILGKNDIFGEMVHLYAKPGKSNADVRALTYCDLHKIQREDLLEVLDMYPEF 851

Query: 533 RRAFET 538
              F T
Sbjct: 852 SDHFLT 857


>gi|26051271 voltage-gated potassium channel, subfamily H, member 2
           isoform b [Homo sapiens]
          Length = 888

 Score =  154 bits (389), Expect = 3e-37
 Identities = 109/420 (25%), Positives = 189/420 (45%), Gaps = 54/420 (12%)

Query: 84  WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENSP---------PWIVFNV 131
           W I  YS F+  WD ++LLL++   +  P    F     EE  P         P  V ++
Sbjct: 398 WTILHYSPFKAVWDWLILLLVIYTAVFTPYSAAFLLKETEEGPPATECGYACQPLAVVDL 457

Query: 132 LSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVE 191
           + D  F++D+++NFRT   V    E++  P  I   Y + WFL+D++++IP D +     
Sbjct: 458 IVDIMFIVDILINFRT-TYVNANEEVVSHPGRIAVHYFKGWFLIDMVAAIPFDLLIFGSG 516

Query: 192 LEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRI 251
            E  +   + KTAR LR+VR  +        +L R   Y               +AV  +
Sbjct: 517 SEELIG--LLKTARLLRLVRVAR--------KLDRYSEY--------------GAAV--L 550

Query: 252 FNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSH----------- 300
           F L+    L+ HW  C+ + +  ++    D  +   H +    G+ Y+            
Sbjct: 551 FLLMCTFALIAHWLACIWYAIGNMEQPHMDSRIGWLHNLGDQIGKPYNSSGLGGPSIKDK 610

Query: 301 ---ALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSR 357
              AL+   S +  +G+G  +P    +   ++  M++G+  YA   G+ +A+IQ L S  
Sbjct: 611 YVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYSGT 670

Query: 358 RQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIIN 416
            +Y  +  +V +++ FH++P   RQR+ EY++H +      D  ++L    E L+ +I  
Sbjct: 671 ARYHTQMLRVREFIRFHQIPNPLRQRLEEYFQHAWSYTNGIDMNAVLKGFPECLQADICL 730

Query: 417 FTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVL 476
              R L+ H   F  A    + A+  K +     PGD +V  G +   +YFI  G + +L
Sbjct: 731 HLNRSLLQHCKPFRGATKGCLRALAMKFKTTHAPPGDTLVHAGDLLTALYFISRGSIEIL 790


>gi|114205399 cyclic nucleotide gated channel beta 1 isoform a [Homo
            sapiens]
          Length = 1251

 Score =  151 bits (381), Expect = 3e-36
 Identities = 119/468 (25%), Positives = 215/468 (45%), Gaps = 50/468 (10%)

Query: 96   WDLIMLLLMVGNLIVLPVGITFFKE--ENSPPWIVFNVLSDTFFLLDLVLNFRTGIVVEE 153
            W   +++    N  ++PV   F  +  +N   W++ + L D  + LD+ + F+T +    
Sbjct: 659  WLFFVVMAWNWNCWLIPVRWAFPYQTPDNIHHWLLMDYLCDLIYFLDITV-FQTRLQFVR 717

Query: 154  GAEILLAPRAIRTRYLRTW-FLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALRIVRF 212
            G +I+   + +R  YL++  F +DL+S +P+D+++L V + P                  
Sbjct: 718  GGDIITDKKDMRNNYLKSRRFKMDLLSLLPLDFLYLKVGVNP------------------ 759

Query: 213  TKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVV-RIFNLIGMMLLLCHWDGCLQFL 271
                    LLRL R ++Y+  +E    +   L+ A V R+      +L   H + CL + 
Sbjct: 760  --------LLRLPRCLKYMAFFEFNSRLESILSKAYVYRVIRTTAYLLYSLHLNSCLYYW 811

Query: 272  VPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLS 331
                Q       +   H V    G  Y    + A+  ++ IG G   P  + ++   +L+
Sbjct: 812  ASAYQG------LGSTHWVYDGVGNSYIRCYYFAVKTLITIG-GLPDPKTLFEIVFQLLN 864

Query: 332  MIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHR 391
               G   +++ IG    ++ +  + +  Y+       +YM+F+K+P   + R+  +YE+ 
Sbjct: 865  YFTGVFAFSVMIGQMRDVVGAATAGQTYYRSCMDSTVKYMNFYKIPKSVQNRVKTWYEYT 924

Query: 392  YQGK-MFDEESILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQ 450
            +  + M DE  ++ +L + +R ++       +V+ + LF   D   +  +L +LR  V+ 
Sbjct: 925  WHSQGMLDESELMVQLPDKMRLDLAIDVNYNIVSKVALFQGCDRQMIFDMLKRLRSVVYL 984

Query: 451  PGDLVVREGSVGRKMYFIQHGLLSVLARGARDTR-----LTDGSYFGEICLLTRG---RR 502
            P D V ++G +GR+MY IQ G + VL  G  D +     L  GS FGEI LL  G   RR
Sbjct: 985  PNDYVCKKGEIGREMYIIQAGQVQVL--GGPDGKSVLVTLKAGSVFGEISLLAVGGGNRR 1042

Query: 503  TASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAFETVAMDRLLRIGKK 550
            TA+V A  +  L+ L     N +L  +P  ++     A  R+LR   K
Sbjct: 1043 TANVVAHGFTNLFILDKKDLNEILVHYPESQKLLRKKAR-RMLRSNNK 1089


>gi|27886646 potassium voltage-gated channel, subfamily H, member 5
           isoform 3 [Homo sapiens]
          Length = 611

 Score =  149 bits (375), Expect = 1e-35
 Identities = 110/435 (25%), Positives = 196/435 (45%), Gaps = 48/435 (11%)

Query: 66  GSHKAVEIEQERVKSAGAWIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEENSPP 125
           GS    + +QE  K+    I+H Y  F+  WD ++L+L     I++P  ++F  ++N+  
Sbjct: 188 GSDILPQYKQEAPKTPPHIILH-YCAFKTTWDWVILILTFYTAIMVPYNVSFKTKQNNIA 246

Query: 126 WIVFNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY 185
           W+V + + D  FL+D+VLNF T   V  G E++  P+ IR  YL+TWF++DL+S +P D 
Sbjct: 247 WLVLDSVVDVIFLVDIVLNFHT-TFVGPGGEVISDPKLIRMNYLKTWFVIDLLSCLPYD- 304

Query: 186 IFLVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLA 245
              ++     +D  +     +L++V         RLLRL R+ R +  + E     Y  A
Sbjct: 305 ---IINAFENVDEGISSLFSSLKVV---------RLLRLGRVARKLDHYLE-----YGAA 347

Query: 246 SAVVRIFNLIGMMLLLCHWDGCLQFLV-------PMLQDFPPDCW-------VSINHMVN 291
             V+    L+ +  L+ HW  C+ + +        +      D W       +   +  N
Sbjct: 348 VLVL----LVCVFGLVAHWLACIWYSIGDYEVIDEVTNTIQIDSWLYQLALSIGTPYRYN 403

Query: 292 HSWG---------RQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMF 342
            S G           Y  +L+  M+ +  IG+G  AP    +   ++  M+VG+  YA  
Sbjct: 404 TSAGIWEGGPSKDSLYVSSLYFTMTSLTTIGFGNIAPTTDVEKMFSVAMMMVGSLLYATI 463

Query: 343 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY-QGKMFDEES 401
            G+ T + Q + ++  +Y E    V  ++  +++P    +R+ +Y    +   K  D E 
Sbjct: 464 FGNVTTIFQQMYANTNRYHEMLNNVRDFLKLYQVPKGLSERVMDYIVSTWSMSKGIDTEK 523

Query: 402 ILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSV 461
           +L    + +R +I     R +    P F  A    + A+  + +     PGDL+   G  
Sbjct: 524 VLSICPKDMRADICVHLNRKVFNEHPAFRLASDGCLRALAVEFQTIHCAPGDLIYHAGES 583

Query: 462 GRKMYFIQHGLLSVL 476
              + F+  G L V+
Sbjct: 584 VDALCFVVSGSLEVI 598


>gi|27886667 potassium voltage-gated channel, subfamily H, member 8
           [Homo sapiens]
          Length = 1107

 Score =  143 bits (361), Expect = 5e-34
 Identities = 122/542 (22%), Positives = 241/542 (44%), Gaps = 61/542 (11%)

Query: 84  WIIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFFKEEN---SPPWIVFNVLSDTFFLLD 140
           +I+  +S F+  WD ++LL      + +P  + F   ++   +    V ++  +  F++D
Sbjct: 212 FILLHFSTFKAGWDWLILLATFYVAVTVPYNVCFIGNDDLSTTRSTTVSDIAVEILFIID 271

Query: 141 LVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEV 200
           ++LNFRT  V + G +++   R+I   Y+ TWF++DLI+++P D ++             
Sbjct: 272 IILNFRTTYVSKSG-QVIFEARSICIHYVTTWFIIDLIAALPFDLLY------------- 317

Query: 201 YKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLL 260
              A  + +V    +L  +RLLRL RL++ + ++ +  H T  L         L+ M  L
Sbjct: 318 ---AFNVTVVSLVHLLKTVRLLRLLRLLQKLDRYSQ--HSTIVLTL-------LMSMFAL 365

Query: 261 LCHWDGCLQFLVPMLQDFPPDC------------------WVSINHMVNHSWGRQYSHAL 302
           L HW  C+ +++  ++                        +   N +   S    Y  AL
Sbjct: 366 LAHWMACIWYVIGKMEREDNSLLKWEVGWLHELGKRLESPYYGNNTLGGPSIRSAYIAAL 425

Query: 303 FKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQE 362
           +  +S +  +G+G  +     +   ++ +M++GA  +A+  G+ TA+IQ + S    Y  
Sbjct: 426 YFTLSSLTSVGFGNVSANTDAEKIFSICTMLIGALMHALVFGNVTAIIQRMYSRWSLYHT 485

Query: 363 KYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEESILGELSEPLREEIINFTCRG 421
           + K ++ ++  H LP   +QR+ EY++  +      D   +L +  + LR +I     + 
Sbjct: 486 RTKDLKDFIRVHHLPQQLKQRMLEYFQTTWSVNNGIDSNELLKDFPDELRSDITMHLNKE 545

Query: 422 LVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGAR 481
           ++  + LF  A    + ++   ++     PG+ ++R+G   + +YF+  G + VL     
Sbjct: 546 IL-QLSLFECASRGCLRSLSLHIKTSFCAPGEYLLRQGDALQAIYFVCSGSMEVLKDSMV 604

Query: 482 DTRLTDGSYFGEICLLTRG--RRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRRAF-ET 538
              L  G   G    +     +  A V+A TYC L  + +     VL+ +P     F E 
Sbjct: 605 LAILGKGDLIGANLSIKDQVIKTNADVKALTYCDLQCIILKGLFEVLDLYPEYAHKFVED 664

Query: 539 VAMDRL--LRIGKKNSILQRKR-----SEPSPGSSGGIMEQ--HLVQHDRDMARGVRGRA 589
           +  D    LR G ++ ++ R       S+  P  +G I ++   +V+ + +   G    A
Sbjct: 665 IQHDLTYNLREGHESDVISRLSNKSMVSQSEPKGNGNINKRLPSIVEDEEEEEEGEEEEA 724

Query: 590 PS 591
            S
Sbjct: 725 VS 726


>gi|116642889 cyclic nucleotide gated channel beta 3 [Homo sapiens]
          Length = 809

 Score =  135 bits (341), Expect = 1e-31
 Identities = 128/538 (23%), Positives = 230/538 (42%), Gaps = 69/538 (12%)

Query: 13  EGATPGLEAVPPVAPPPATAASGPIPKSGPEPKRRHLGTLLQPTVNKFSLRVFGSHKAVE 72
           EG     EA P  A P A     P+ +S  +P   H   LL   V K  L  +       
Sbjct: 152 EGDLSSPEASPQTAKPTAVP---PVKESDDKPTE-HYYRLLWFKVKKMPLTEY------- 200

Query: 73  IEQERVKSAGAWIIHPYSDFRFY--WDLIMLLLMVGNLIVLPVGITFFKE--ENSPPWIV 128
              +R+K   +  I  Y+D R Y  W L++ L    N   +P+ + F  +  +N   W++
Sbjct: 201 --LKRIKLPNS--IDSYTD-RLYLLWLLLVTLAYNWNCCFIPLRLVFPYQTADNIHYWLI 255

Query: 129 FNVLSDTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRY-LRTWFLVDLISSIPVDYIF 187
            +++ D  +L D++   +  +    G +I++    +R  Y   T F +D+ S IP D  +
Sbjct: 256 ADIICDIIYLYDMLF-IQPRLQFVRGGDIIVDSNELRKHYRTSTKFQLDVASIIPFDICY 314

Query: 188 LVVELEPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASA 247
           L     P   A                     R+L+ +    + H  E I    Y     
Sbjct: 315 LFFGFNPMFRAN--------------------RMLKYTSFFEFNHHLESIMDKAY----- 349

Query: 248 VVRIFNLIGMMLLLCHWDGCLQFLVPMLQDFPPDCWVSINHMVNHSWGRQYSHALFKAMS 307
           + R+    G +L + H + C+ +     +      WV          G +Y    + A+ 
Sbjct: 350 IYRVIRTTGYLLFILHINACVYYWASNYEGIGTTRWVYDGE------GNEYLRCYYWAVR 403

Query: 308 HMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDSSRRQYQEKYKQV 367
            ++ IG G   P  + ++   +L+   G   ++  IG    +I +  +++  ++      
Sbjct: 404 TLITIG-GLPEPQTLFEIVFQLLNFFSGVFVFSSLIGQMRDVIGAATANQNYFRACMDDT 462

Query: 368 EQYMSFHKLPADTRQRIHEYYEHRYQG-KMFDEESILGELSEPLREEI---INFTCRGLV 423
             YM+ + +P   ++R+  +YE+ +   +M DE  +L  L   ++  +   +NF+   ++
Sbjct: 463 IAYMNNYSIPKLVQKRVRTWYEYTWDSQRMLDESDLLKTLPTTVQLALAIDVNFS---II 519

Query: 424 AHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSVGRKMYFIQHGLLSVLARGARDT 483
           + + LF   D   +  +L +L+  ++ PGD V ++G +G++MY I+HG + VL  G   T
Sbjct: 520 SKVDLFKGCDTQMIYDMLLRLKSVLYLPGDFVCKKGEIGKEMYIIKHGEVQVLG-GPDGT 578

Query: 484 R----LTDGSYFGEICLLTRG---RRTASVRADTYCRLYSLSVDHFNAVLEEFPMMRR 534
           +    L  GS FGEI LL  G   RRTA+V A  +  L +L       +L  +P   R
Sbjct: 579 KVLVTLKAGSVFGEISLLAAGGGNRRTANVVAHGFANLLTLDKKTLQEILVHYPDSER 636


>gi|38569493 potassium voltage-gated channel, subfamily H
           (eag-related), member 3 [Homo sapiens]
          Length = 1083

 Score =  134 bits (338), Expect = 2e-31
 Identities = 125/493 (25%), Positives = 213/493 (43%), Gaps = 85/493 (17%)

Query: 93  RFYWDLIMLLLMVGNLIVLP--VGITFFKEENSP--PWIVFNVLSDTFFLLDLVLNFRTG 148
           R  WD  +LL  +   + +P  V ++  +E ++   P  V ++  +  F+LD+VLNFRT 
Sbjct: 224 RATWDGFILLATLYVAVTVPYSVCVSTAREPSAARGPPSVCDLAVEVLFILDIVLNFRTT 283

Query: 149 IVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDYIFLVVELEPRLDAEVYKTARALR 208
            V + G +++ AP++I   Y+ TWFL+D+I+++P D +             VY  A  L+
Sbjct: 284 FVSKSG-QVVFAPKSICLHYVTTWFLLDVIAALPFDLLHA-------FKVNVYFGAHLLK 335

Query: 209 IVRFTKILSLLRLL-RLSRLIRYIHQWEEIFHMTYDLASAVVRIFNLIGMMLLLCHWDGC 267
            VR   +L LLRLL RL R  +Y               SAVV    L+ +  LL HW  C
Sbjct: 336 TVR---LLRLLRLLPRLDRYSQY---------------SAVVLTL-LMAVFALLAHWVAC 376

Query: 268 LQFLVPMLQ------DFPPDCWVS------------------------------------ 285
           + F +   +      + P   W+                                     
Sbjct: 377 VWFYIGQREIESSESELPEIGWLQELARRLETPYYLVGRRPAGGNSSGQSDNCSSSSEAN 436

Query: 286 ---INHMVNHSWGRQYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMF 342
              +  +   S    Y  +L+ A+S +  +G+G  +     +   ++ +M++GA  +A+ 
Sbjct: 437 GTGLELLGGPSLRSAYITSLYFALSSLTSVGFGNVSANTDTEKIFSICTMLIGALMHAVV 496

Query: 343 IGHATALIQSLDSSRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRYQ-GKMFDEES 401
            G+ TA+IQ + + R  Y  + + +  Y+  H++P   +QR+ EY++  +      D   
Sbjct: 497 FGNVTAIIQRMYARRFLYHSRTRDLRDYIRIHRIPKPLKQRMLEYFQATWAVNNGIDTTE 556

Query: 402 ILGELSEPLREEIINFTCRGLVAHMPLFAHADPSFVTAVLTKLRFEVFQPGDLVVREGSV 461
           +L  L + LR +I     +  V  +PLF  A    + A+   LR     PG+ ++ +G  
Sbjct: 557 LLQSLPDELRADIAMHLHKE-VLQLPLFEAASRGCLRALSLALRPAFCTPGEYLIHQGDA 615

Query: 462 GRKMYFIQHGLLSVLARGARDTRLTDGSYFGEICLLTRGRRTASVRAD----TYCRLYSL 517
            + +YF+  G + VL  G     L  G   G  C L R  +     AD    TYC L  L
Sbjct: 616 LQALYFVCSGSMEVLKGGTVLAILGKGDLIG--CELPRREQVVKANADVKGLTYCVLQCL 673

Query: 518 SVDHFNAVLEEFP 530
            +   +  L  +P
Sbjct: 674 QLAGLHDSLALYP 686



 Score = 34.7 bits (78), Expect = 0.35
 Identities = 34/112 (30%), Positives = 40/112 (35%), Gaps = 16/112 (14%)

Query: 629  GPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGR 688
            G  P     P  L+A   W    S +SP  P     W STS    P +  L +  S    
Sbjct: 959  GTWPHPRPGPPPLMAPWPWGPPASQSSPW-PRATAFWTSTSDSEPPASGDLCSEPSTPA- 1016

Query: 689  SQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLP 740
                   PPP   G R GP       ++P     AT  G P   GSG   LP
Sbjct: 1017 ------SPPPSEEGARTGP-------AEPVSQAEATSTGEP-PPGSGGLALP 1054


>gi|27886665 potassium voltage-gated channel, subfamily H, member 7
           isoform 2 [Homo sapiens]
          Length = 732

 Score =  119 bits (299), Expect = 8e-27
 Identities = 90/337 (26%), Positives = 159/337 (47%), Gaps = 57/337 (16%)

Query: 85  IIHPYSDFRFYWDLIMLLLMVGNLIVLPVGITFF---KEENS--------PPWIVFNVLS 133
           I+H YS F+  WD ++LLL++   I  P    F    +EE           P  V +++ 
Sbjct: 393 ILH-YSPFKAVWDWLILLLVIYTAIFTPYSAAFLLNDREEQKRRECGYSCSPLNVVDLIV 451

Query: 134 DTFFLLDLVLNFRTGIVVEEGAEILLAPRAIRTRYLRTWFLVDLISSIPVDY-IFLVVEL 192
           D  F++D+++NFRT   V +  E++  P  I   Y + WFL+D++++IP D  IF     
Sbjct: 452 DIMFIIDILINFRT-TYVNQNEEVVSDPAKIAIHYFKGWFLIDMVAAIPFDLLIFGSGSD 510

Query: 193 EPRLDAEVYKTARALRIVRFTKILSLLRLLRLSRLIRYIHQWEEIFHMTYDLASAVVRIF 252
           E      + KTAR LR+VR  +        +L R   Y               +AV+ + 
Sbjct: 511 ETTTLIGLLKTARLLRLVRVAR--------KLDRYSEY--------------GAAVLML- 547

Query: 253 NLIGMMLLLCHWDGCLQFLV-----PMLQDFPPDCWV-SINHMVNHSWGR---------- 296
            L+ +  L+ HW  C+ + +     P L D     W+ S+   +   +            
Sbjct: 548 -LMCIFALIAHWLACIWYAIGNVERPYLTD--KIGWLDSLGQQIGKRYNDSDSSSGPSIK 604

Query: 297 -QYSHALFKAMSHMLCIGYGQQAPVGMPDVWLTMLSMIVGATCYAMFIGHATALIQSLDS 355
            +Y  AL+   S +  +G+G  +P    +   ++  M++G+  YA   G+ +A+IQ L S
Sbjct: 605 DKYVTALYFTFSSLTSVGFGNVSPNTNSEKIFSICVMLIGSLMYASIFGNVSAIIQRLYS 664

Query: 356 SRRQYQEKYKQVEQYMSFHKLPADTRQRIHEYYEHRY 392
              +Y  +  +V++++ FH++P   RQR+ EY++H +
Sbjct: 665 GTARYHMQMLRVKEFIRFHQIPNPLRQRLEEYFQHAW 701


>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
          Length = 538

 Score = 53.5 bits (127), Expect = 7e-07
 Identities = 41/123 (33%), Positives = 54/123 (43%), Gaps = 16/123 (13%)

Query: 648 RSAGSPASPLVPVRAGPWAS-------TSRLPAPPARTLHASLSRAGRSQVSLLGPPPGG 700
           R A  PA P  P R  P A+       T   P PPA    A+ +RA R+  +    PP  
Sbjct: 104 RGATPPAPPRAP-RGAPAAAAAAAPPPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSP 162

Query: 701 GGRRLGPRGR---PLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRP 757
           G  + GPR +   PL+A  P+ P        P    +G  R PP  + A+ P    PP+P
Sbjct: 163 GPAQPGPRAQRAAPLAAPPPA-PAAPPAVAPP----AGPRRAPPPAVAAREPPLPPPPQP 217

Query: 758 PVP 760
           P P
Sbjct: 218 PAP 220



 Score = 43.5 bits (101), Expect = 7e-04
 Identities = 67/246 (27%), Positives = 84/246 (34%), Gaps = 37/246 (15%)

Query: 544 LLRIGKKNSILQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPSTGAQLSGKPVLW 603
           +LR+  K SI  R  +   P   G               R  RG AP+  A  +  P   
Sbjct: 82  VLRVSYKGSISYRNAARVQPPRRGATPPAP--------PRAPRG-APAAAAAAAPPPTPA 132

Query: 604 EPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSP--------AS 655
            P   AP+ AAA       A      P    P  P     R+A  +A  P        A 
Sbjct: 133 PPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAP 192

Query: 656 PLVPVRAGPWASTSR---LPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPL 712
           P  P RA P A  +R   LP PP         +    Q     PPP GG  R G   RP+
Sbjct: 193 PAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPPQPQ---PPPEGGAVRAGGAARPV 249

Query: 713 SASQPSLPQRATGDGSPGR------KGSGSERLPPSGLLAKP-------PRTAQPPRPPV 759
           S  +       +G G+ GR      +G   E     G L +        PR  +P R P 
Sbjct: 250 SLREVVRYLGGSG-GAGGRLTRGRVQGLLEEEAAARGRLERTRLGALALPRGDRPGRAPP 308

Query: 760 PEPATP 765
              A P
Sbjct: 309 AASARP 314


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 69/249 (27%), Positives = 95/249 (38%), Gaps = 45/249 (18%)

Query: 535 AFETVAMDRLLRIGKKNSI---LQRKRSEPSPGSSGGIMEQHLVQHDRDMARGVRGRAPS 591
           A ETVA  +     K++++    +R  S P+PG+    M +      R  A G     P 
Sbjct: 138 AEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMAR------RSRAAGTEVGLPR 191

Query: 592 TGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAG 651
                S +P    P    P ++ +  S  +   T +  P      S    L R A RS  
Sbjct: 192 PAP--SARP---RPPTEGPRKSVSSASEHS---TTEPSPAARRRPSAGGGLQRPASRSLS 243

Query: 652 SPASPLV-PVRAGPWA-STSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGRRLGP-R 708
           S A+PL  P R+GP A  T R PA P++     L      QV+   PP       LGP  
Sbjct: 244 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVT---PPRKDAAPALGPLS 300

Query: 709 GRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPV--------P 760
             PL+   PS              G+ +  +PP    A P     PP PP+        P
Sbjct: 301 SSPLATPSPS--------------GTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPP 346

Query: 761 EPATPRGLQ 769
            P+ P  LQ
Sbjct: 347 SPSAPPSLQ 355



 Score = 39.3 bits (90), Expect = 0.014
 Identities = 40/146 (27%), Positives = 51/146 (34%), Gaps = 16/146 (10%)

Query: 630 PLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPARTLHASLSRAGRS 689
           P P  P +PA L    A  + G    PL     G   +T    AP A    +    AG S
Sbjct: 33  PRPPPPVTPAALRVLGAAGAVGR--KPLAERAGGIGGATIPESAPRAGPTRS----AGTS 86

Query: 690 QVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPP 749
             +    PP  G     P  +  S    S P RA+G   PG  G    R+     +A+  
Sbjct: 87  SRNPASRPPASGRGERAPPAKNTSPGPVSSPGRASGTTRPGPLGQKGLRISAEETVARGK 146

Query: 750 RTAQPPRPPV----------PEPATP 765
            T  P R  +          P P TP
Sbjct: 147 ATEAPKRSALSAGARRDTSGPTPGTP 172



 Score = 37.4 bits (85), Expect = 0.053
 Identities = 44/172 (25%), Positives = 66/172 (38%), Gaps = 20/172 (11%)

Query: 605 PLVHAPLQAAA---VTSNVAIALTHQRGPLPLSPDSPATLLARSAWRSAGSPASPLVPVR 661
           P + APL   A   + ++++ A++    PL + P    + LA      + SP +PL  + 
Sbjct: 455 PPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHPLQALSSLA------SHSPQAPLSSLI 508

Query: 662 AGPWASTSRLPAPPARTLHASLSRAGRSQVSLLGPPPGGGGR--------RLGPRGRPLS 713
             P  + S L  P  +T  ASL+      +  L PPP                P   P  
Sbjct: 509 MPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQTASAPLTTPHLETPPCPAPCP 568

Query: 714 ASQPSLPQRATGDGSPGRKGSGSERLPPSGLLAKPPRTAQPPRPPVPEPATP 765
              P  P       +P    +   + PP+  LA PP     P PP+   ATP
Sbjct: 569 LQAPPSPLTTPPPETPSSIATPPPQAPPA--LASPPLQGL-PSPPLSPLATP 617



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 54/208 (25%), Positives = 75/208 (36%), Gaps = 24/208 (11%)

Query: 575 VQHDRDMAR-GVRGRAPSTGA------QLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQ 627
           + + RD A+ G   R P+  A      +  G P    P+  A L+       V      +
Sbjct: 1   MDNKRDKAKAGAAARTPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAE 60

Query: 628 R----GPLPLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWASTSRLPAPPAR-TLHAS 682
           R    G   +   +P     RSA  S+ +PAS        P AS     APPA+ T    
Sbjct: 61  RAGGIGGATIPESAPRAGPTRSAGTSSRNPASR-------PPASGRGERAPPAKNTSPGP 113

Query: 683 LSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPS 742
           +S  GR+  +    P G  G R+              P+R+       R  SG     PS
Sbjct: 114 VSSPGRASGTTRPGPLGQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPS 173

Query: 743 GLLAKPPRTAQP----PRP-PVPEPATP 765
             +A+  R A      PRP P   P  P
Sbjct: 174 PAMARRSRAAGTEVGLPRPAPSARPRPP 201



 Score = 32.7 bits (73), Expect = 1.3
 Identities = 40/152 (26%), Positives = 52/152 (34%), Gaps = 22/152 (14%)

Query: 635 PDSPATLLARSAWRSAGSPASPLV--PVRAGPWASTSRLPAPPARTLHASLSRAGRSQ-- 690
           P +P  L +         P SPL   P +A P  +   L APP+      LS        
Sbjct: 592 PQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPPLQAPPSPPASPPLSPLATPSPQ 651

Query: 691 ------VSLL----GPPPGGGGRRLGPRGRPLS--ASQPSLPQRATGDGSPGRKGSGSER 738
                 V LL     PPP        P   P S  AS P  P       +P    +   +
Sbjct: 652 APNALAVHLLQAPFSPPPSP------PVQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQ 705

Query: 739 LPPSGLLAKPPRTAQPPRPPVPEPATPRGLQL 770
           +PPS   + P   +  P P  P P     LQ+
Sbjct: 706 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQV 737



 Score = 30.4 bits (67), Expect = 6.5
 Identities = 39/149 (26%), Positives = 48/149 (32%), Gaps = 26/149 (17%)

Query: 635 PDSPATLLARSAWRSAGSPASPLV------PVRAGPWASTSRLPAPPARTLHASLSRAGR 688
           P +P  L A         PASP +      P R  P  +   L  PP+      +S    
Sbjct: 724 PQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMS---- 779

Query: 689 SQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGSERLPPSG--LLA 746
               L  PPP        P  + L +   S P +A    S     S     PP    +LA
Sbjct: 780 ---PLAKPPPQAPPALATPPLQALPSPPASFPGQAPFSPSASLPMSPLATPPPQAPPVLA 836

Query: 747 KP-----------PRTAQPPRPPVPEPAT 764
            P           P    P RPP P P T
Sbjct: 837 APLLQVPPSPPASPTLQAPRRPPTPGPDT 865



 Score = 30.0 bits (66), Expect = 8.5
 Identities = 40/153 (26%), Positives = 48/153 (31%), Gaps = 18/153 (11%)

Query: 627 QRGPLPLSPDSPATLL-----------ARSAWRSAGSPASPLVPVRAGPWASTSRLPAPP 675
           Q  P PL+   P T             A ++    G P+ PL P+   P  +   L  PP
Sbjct: 570 QAPPSPLTTPPPETPSSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALPP 629

Query: 676 ARTLHASLSRAGRSQVSLLGPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSG 735
              L A  S      +S L  P       L         S P  P        P      
Sbjct: 630 ---LQAPPSPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVS 686

Query: 736 SERLPPSGL---LAKPPRTAQPPRPPVPEPATP 765
               PPS     LA PP    PP PP   P +P
Sbjct: 687 PSATPPSQAPPSLAAPPLQV-PPSPPASPPMSP 718


>gi|112734870 hypothetical protein LOC57648 [Homo sapiens]
          Length = 1094

 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 57/199 (28%), Positives = 69/199 (34%), Gaps = 31/199 (15%)

Query: 592 TGAQLSGKPVLWEPLVHAPLQAAAVTSNVAIALTHQRGPLPLSP-----DSPATLLARSA 646
           +  QLSG+ V    L   P       S     L    GPL L P       P      + 
Sbjct: 480 SSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGLAVPDGPLGLPPKPERKQQPQLPRPPTT 539

Query: 647 WRSAGSPASPLVPVRAGPWA------STSRLPAPPARTLHASLSRAGRSQVSLLGPPPGG 700
             S G+ A+P  P  A  W        + R P  P RTL  S   + +S    L PP G 
Sbjct: 540 GGSEGAGAAPCPPNPANSWVPGLSPGGSRRPPRSPERTLSPSSGYSSQSGTPTL-PPKGL 598

Query: 701 GGRRLGPRGRPLSASQPSLPQRATGDGSPGRKGSGS--------------ERLPPSGLLA 746
            G    P       +QP  P+R T   SPG   S S              +R  P  L  
Sbjct: 599 AGPPASP-----GKAQPPKPERVTSLRSPGASVSSSLTSLCSSSSDPAPSDRSGPQILTP 653

Query: 747 KPPRTAQPPRPPVPEPATP 765
              R   PP P VP P +P
Sbjct: 654 LGDRFVIPPHPKVPAPFSP 672



 Score = 34.3 bits (77), Expect = 0.45
 Identities = 26/89 (29%), Positives = 36/89 (40%), Gaps = 17/89 (19%)

Query: 696 PPPGGGGRRLGPRGRPLSASQPSLPQRATGDGS---------------PGRKGSGSER-- 738
           PPP GG  R  P G   + +  +L  R++G  S               P R  S  +R  
Sbjct: 453 PPPQGGSGRGSPSGGSTAEASDTLSIRSSGQLSGRSVSLRKLKRPPPPPRRTHSLHQRGL 512

Query: 739 LPPSGLLAKPPRTAQPPRPPVPEPATPRG 767
             P G L  PP+  +  +P +P P T  G
Sbjct: 513 AVPDGPLGLPPKPERKQQPQLPRPPTTGG 541



 Score = 30.8 bits (68), Expect = 5.0
 Identities = 43/154 (27%), Positives = 57/154 (37%), Gaps = 23/154 (14%)

Query: 632 PLSPDSPATLLARSAWRSAGSPASPLVPVRAGPWAST----SRLP-----------APPA 676
           P +  S AT L     +  GSP  P  P    P +S     ++LP            PP 
Sbjct: 815 PAASSSSATALQI---QPPGSPDPPPAPPAPAPASSAPGHVAKLPQKEPVGCSKGGGPPR 871

Query: 677 RTLHASLSRAGRSQVSLL---GPPPGGGGRRLGPRGRPLSASQPSLPQRATGDGSPGRKG 733
             + A L      Q+  L   G P G     LGP   P    + +L  RA+   +P    
Sbjct: 872 EDVGAPLVTPSLLQMVRLRSVGAPGGAPTPALGPSA-PQKPLRRALSGRASPVPAPSSGL 930

Query: 734 SGSERLPPSGLLAKPP-RTAQPPRPPVPEPATPR 766
             + RL    L A     +AQP  PP  EP  P+
Sbjct: 931 HAAVRLKACSLAASEGLSSAQPNGPPEAEPRPPQ 964


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.423 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,516,201
Number of Sequences: 37866
Number of extensions: 1867574
Number of successful extensions: 20313
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 174
Number of HSP's successfully gapped in prelim test: 928
Number of HSP's that attempted gapping in prelim test: 13931
Number of HSP's gapped (non-prelim): 6162
length of query: 774
length of database: 18,247,518
effective HSP length: 110
effective length of query: 664
effective length of database: 14,082,258
effective search space: 9350619312
effective search space used: 9350619312
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.